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Sample records for male fibroblast nuclei

  1. Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes.

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    Andreas Bolzer

    2005-05-01

    Full Text Available Studies of higher-order chromatin arrangements are an essential part of ongoing attempts to explore changes in epigenome structure and their functional implications during development and cell differentiation. However, the extent and cell-type-specificity of three-dimensional (3D chromosome arrangements has remained controversial. In order to overcome technical limitations of previous studies, we have developed tools that allow the quantitative 3D positional mapping of all chromosomes simultaneously. We present unequivocal evidence for a probabilistic 3D order of prometaphase chromosomes, as well as of chromosome territories (CTs in nuclei of quiescent (G0 and cycling (early S-phase human diploid fibroblasts (46, XY. Radial distance measurements showed a probabilistic, highly nonrandom correlation with chromosome size: small chromosomes-independently of their gene density-were distributed significantly closer to the center of the nucleus or prometaphase rosette, while large chromosomes were located closer to the nuclear or rosette rim. This arrangement was independently confirmed in both human fibroblast and amniotic fluid cell nuclei. Notably, these cell types exhibit flat-ellipsoidal cell nuclei, in contrast to the spherical nuclei of lymphocytes and several other human cell types, for which we and others previously demonstrated gene-density-correlated radial 3D CT arrangements. Modeling of 3D CT arrangements suggests that cell-type-specific differences in radial CT arrangements are not solely due to geometrical constraints that result from nuclear shape differences. We also found gene-density-correlated arrangements of higher-order chromatin shared by all human cell types studied so far. Chromatin domains, which are gene-poor, form a layer beneath the nuclear envelope, while gene-dense chromatin is enriched in the nuclear interior. We discuss the possible functional implications of this finding.

  2. Three-dimensional positioning of B chromosomes in fibroblast nuclei of the red fox and the chinese raccoon dog.

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    Kociucka, B; Sosnowski, J; Kubiak, A; Nowak, A; Pawlak, P; Szczerbal, I

    2013-01-01

    Great progress has been achieved over the last years in studies on chromosome arrangement in mammalian cell nuclei. Growing evidence indicates that the genome's spatial organization is of functional relevance. So far, no attention has been paid to the nuclear organization of B chromosomes (Bs). In this study we have examined nuclear positioning of Bs in 2 species from the Canidae family--the red fox and the Chinese raccoon dog. Using 2D and 3D fluorescence in situ hybridization and 2 gene-specific probes (C-KIT and PDGFRA), we analyzed the location of Bs in fibroblast nuclei. We found that small Bs of the red fox occupied mostly the interior of the nucleus, while medium-sized Bs of the Chinese raccoon dog were observed in the peripheral area of the nucleus as well as in intermediate and interior locations. The more uniform distribution of B chromosomes in the Chinese raccoon dog may be the result of differences in their size, since 3 morphological types of Bs are distinguished in this species. Our results indicate that 3D positioning of B chromosomes in fibroblast nuclei of the 2 canid species is in agreement with the chromosome size-dependent theory. Copyright © 2013 S. Karger AG, Basel.

  3. Aberrant tryptophan transport in cultured fibroblast from patients with Male Idiopathic Osteoporosis: An in vitro study

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    Ylva Pernow

    2018-06-01

    Full Text Available It has been demonstrated, that long-term chronic tryptophan deficiency, results in decreased serotonin synthesis, which may lead to low bone mass and low bone formation. Findings from studies in male patients with idiopathic osteoporosis suggested a decreased transport of tryptophan in erythrocytes of osteoporotic patients, indicating that serotonin system defects may be involved in the etiology of low bone mass. Tryptophan is the precursor of serotonin, and a disturbed transport of tryptophan is implicated in altered serotonin synthesis. However, no study has investigated the tryptophan transport kinetics in MIO patients. The aim of this study is to investigate the kinetic parameters of tryptophan transport in fibroblasts derived from MIO patients compared to age and sex matched controls.Fibroblast cells were cultured from skin biopsies obtained from 14 patients diagnosed with Male Idiopathic Osteoporosis and from 13 healthy age-sex matched controls, without a diagnosis of osteoporosis. Transport of the amino acid tryptophan across the cell membrane was measured by the cluster tray method. The kinetic parameters, maximal transport capacity (Vmax and affinity constant (Km were determined by using the Lineweaver-Burke plot equation.The results of this study have shown a significantly lower mean value for Vmax (p=0.0138 and lower Km mean value (p=0.0009 of tryptophan transport in fibroblasts of MIO patients compared to the control group. A lower Vmax implied a decreased tryptophan transport availability in MIO patients.In conclusion, reduced cellular tryptophan availability in MIO patients might result in reduced brain serotonin synthesis and its endogenous levels in peripheral tissues, and this may contribute to low bone mass/formation. The findings of the present study could contribute to the etiology of idiopathic osteoporosis and for the development of novel approaches for diagnosis, treatment and management strategies of MIO. Keywords: Male

  4. Embryonic effects transmitted by male mice irradiated with 512 MeV/u 56Fe nuclei

    International Nuclear Information System (INIS)

    Wiley, L.M.; Van Beek, M.E.A.B.; Raabe, O.G.

    1994-01-01

    High-energy, high-charge nuclei may contribute substantially to the yearly equivalent dose in space flight from galactic cosmic radiation (GCR) at solar minimum. The largest single heavy-ion component is 56 Fe. We used the mouse embryo chimera assay to test 512 MeV/u 56 Fe nuclei for effects on the rate of proliferation of embryonic cells transmitted by sperm from irradiated mice. Male CD1 mice were acutely irradiated with 0.01, 0.05, or 0.1 Gy (LET, 184 keV/μm; fluence, 3.5 x 10 4 -3.3 x 10 5 nuclei/cm 2 ; average dose rate, 0.02 Gy/min) at the Lawrence Berkeley Laboratory BEVATRON/BEVALAC Facility in Berkeley, CA. Irradiated males were bred weekly for 7 weeks to nonirradiated females and their four-cell embryos were paired with control embryos, forming aggregation chimeras. After 30-35 h of culture, chimeras were dissociated to obtain open-quotes proliferation ratiosclose quotes (number of cells contributed by the embryo from the irradiated male/total number of cells in the chimera). Significant dose-dependent decreases in proliferation ratios were obtained across all three dose groups for postirradiation week 2 (P 56 Fe nuclei. However, up to 47% of sperm during postirradiation weeks 1 and 2 transmitted proliferation ratios that were at or below one standard deviation from control mean proliferation ratios. 26 refs., 4 figs., 10 tabs

  5. nuclei

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    Minkov N.

    2016-01-01

    Full Text Available We study the effects of quadrupole-octupole deformations on the energy and magnetic properties of high-K isomeric states in even-even heavy and superheavy nuclei. The neutron two-quasiparticle (2qp isomeric energies and magnetic dipole moments are calculated within a deformed shell model with the Bardeen-Cooper- Schrieffer (BCS pairing interaction over a wide range of quadrupole and octupole deformations. We found that in most cases the magnetic moments exhibit a pronounced sensitivity to the octupole deformation, while the 2qp energies indicate regions of nuclei in which the presence of high-K isomeric states may be associated with the presence of octupole softness or even with octupole deformation. In the present work we also examine the influence of the BCS pairing strength on the energy of the blocked isomer configuration. We show that the formation of 2qp energy minima in the space of quadrupole-octupole and eventually higher multipolarity deformations is a subtle effect depending on nuclear pairing correlations.

  6. De novo frameshift mutation in fibroblast growth factor 8 in a male patient with gonadotropin deficiency.

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    Suzuki, Erina; Yatsuga, Shuichi; Igarashi, Maki; Miyado, Mami; Nakabayashi, Kazuhiko; Hayashi, Keiko; Hata, Kenichirou; Umezawa, Akihiro; Yamada, Gen; Ogata, Tsutomu; Fukami, Maki

    2014-01-01

    Missense, nonsense, and splice mutations in the Fibroblast Growth Factor 8(FGF8) have recently been identified in patients with hypothalamo-pituitary dysfunction and craniofacial anomalies. Here, we report a male patient with a frameshift mutation in FGF8. The patient exhibited micropenis, craniofacial anomalies, and ventricular septal defect at birth. Clinical evaluation at 16 years and 8 months of age revealed delayed puberty, hyposmia, borderline mental retardation, and mild hearing difficulty. Endocrine findings included gonadotropin deficiency and primary hypothyroidism. Molecular analysis identified a de novo heterozygous p.S192fsX204 mutation in the last exon of FGF8. RT-PCR analysis of normal human tissues detected FGF8 expression in the genital skin, and whole-mount in situ hybridization analysis of mouse embryos revealed Fgf8 expression in the anlage of the penis. The results indicate that frameshift mutations in FGF8 account for a part of the etiology of hypothalamo-pituitary dysfunction. Micropenis in patients with FGF8 abnormalities appears to be caused by gonadotropin deficiency and defective outgrowth of the anlage of the penis.

  7. Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice.

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    Douris, Nicholas; Stevanovic, Darko M; Fisher, Ffolliott M; Cisu, Theodore I; Chee, Melissa J; Nguyen, Ngoc L; Zarebidaki, Eleen; Adams, Andrew C; Kharitonenkov, Alexei; Flier, Jeffrey S; Bartness, Timothy J; Maratos-Flier, Eleftheria

    2015-07-01

    Fibroblast growth factor 21 (FGF21) has multiple metabolic actions, including the induction of browning in white adipose tissue. Although FGF21 stimulated browning results from a direct interaction between FGF21 and the adipocyte, browning is typically associated with activation of the sympathetic nervous system through cold exposure. We tested the hypothesis that FGF21 can act via the brain, to increase sympathetic activity and induce browning, independent of cell-autonomous actions. We administered FGF21 into the central nervous system via lateral ventricle infusion into male mice and found that the central treatment increased norepinephrine turnover in target tissues that include the inguinal white adipose tissue and brown adipose tissue. Central FGF21 stimulated browning as assessed by histology, expression of uncoupling protein 1, and the induction of gene expression associated with browning. These effects were markedly attenuated when mice were treated with a β-blocker. Additionally, neither centrally nor peripherally administered FGF21 initiated browning in mice lacking β-adrenoceptors, demonstrating that an intact adrenergic system is necessary for FGF21 action. These data indicate that FGF21 can signal in the brain to activate the sympathetic nervous system and induce adipose tissue thermogenesis.

  8. Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress

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    Worman Howard J

    2005-06-01

    Full Text Available Abstract Background Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670 is a rare sporadic disorder with an incidence of approximately 1 per 8 million live births. The phenotypic appearance consists of short stature, sculptured nose, alopecia, prominent scalp veins, small face, loss of subcutaneous fat, faint mid-facial cyanosis, and dystrophic nails. HGPS is caused by mutations in LMNA, the gene that encodes nuclear lamins A and C. The most common mutation in subjects with HGPS is a de novo single-base pair substitution, G608G (GGC>GGT, within exon 11 of LMNA. This creates an abnormal splice donor site, leading to expression of a truncated protein. Results We studied a new case of a 5 year-old girl with HGPS and found a heterozygous point mutation, G608G, in LMNA. Complementary DNA sequencing of RNA showed that this mutation resulted in the deletion of 50 amino acids in the carboxyl-terminal tail domain of prelamin A. We characterized a primary dermal fibroblast cell line derived from the subject's skin. These cells expressed the mutant protein and exhibited a normal growth rate at early passage in primary culture but showed alterations in nuclear morphology. Expression levels and overall distributions of nuclear lamins and emerin, an integral protein of the inner nuclear membrane, were not dramatically altered. Ultrastructural analysis of the nuclear envelope using electron microscopy showed that chromatin is in close association to the nuclear lamina, even in areas with abnormal nuclear envelope morphology. The fibroblasts were hypersensitive to heat shock, and demonstrated a delayed response to heat stress. Conclusion Dermal fibroblasts from a subject with HGPS expressing a mutant truncated lamin A have dysmorphic nuclei, hypersensitivity to heat shock, and delayed response to heat stress. This suggests that the mutant protein, even when expressed at low levels, causes defective cell stability, which may be responsible for phenotypic

  9. Comparative study on the song behavior and song control nuclei in male and female Mongolian larks (Melanocorypha mongolica).

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    Zhang, Xuebo; Zeng, Shaoju; Zhang, Xinwen; Zuo, Mingxue

    2011-09-12

    Songbirds can produce a remarkable diversity of songs, which is well-characterized learned behavior that reflects the basic processes of language learning in humans. As song control nuclei governing song behavior has been identified, bird song provides an excellent model to address the relationship between brain areas and their controlling behavior. The Mongolian lark (Melanocorypha mongolica), a species of the Alaudidae family, is well known for its elaborate singing and ability to learn new songs, even in adulthood. Here, we studied the singing behavior and underlying neural structures of the Mongolian lark in both sexes. We found that the sizes of song bouts and song phrases (song repertoires) in male Mongolian larks are extremely large, and that each song repertoire or phrase has a complex structure, comprising several different syllables that seldom appear in other types of song bouts. In accordance with these complex songs, Mongolian lark song control nuclei are well developed and can be easily detected by Nissl staining. In contrast to male Mongolian larks, females were not observed to sing. However, they possess significant song control nuclei with abundant neural connectivity within them despite their small sizes compared with males. These data provide new evidence that help further clarify the mechanisms by which songbirds sing. Our results also have implications for the evolution of complex birdsongs and song control nuclei in oscine birds. Copyright © 2011 Elsevier B.V. All rights reserved.

  10. Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination

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    Kim, Yuna; Bingham, Nathan; Sekido, Ryohei; Parker, Keith L.; Lovell-Badge, Robin; Capel, Blanche

    2007-01-01

    Targeted mutagenesis of Fgf9 in mice causes male-to-female sex reversal. Among the four FGF receptors, FGFR2 showed two highly specific patterns based on antibody staining, suggesting that it might be the receptor-mediating FGF9 signaling in the gonad. FGFR2 was detected at the plasma membrane in proliferating coelomic epithelial cells and in the nucleus in Sertoli progenitor cells. This expression pattern suggested that Fgfr2 might play more than one role in testis development. To test the hypothesis that Fgfr2 is required for male sex determination, we crossed mice carrying a floxed allele of Fgfr2 with two different Cre lines to induce a temporal or cell-specific deletion of this receptor. Results show that deletion of Fgfr2 in embryonic gonads phenocopies deletion of Fgf9 and leads to male-to-female sex reversal. Using these two Cre lines, we provide the first genetic evidence that Fgfr2 plays distinct roles in proliferation and Sertoli cell differentiation during testis development. PMID:17940049

  11. Phage T4 endonuclease V stimulates DNA repair replication in isolated nuclei from ultraviolet-irradiated human cells, including xeroderma pigmentosum fibroblasts

    International Nuclear Information System (INIS)

    Smith, C.A.; Hanawalt, P.C.

    1978-01-01

    The repair mode of DNA replication has been demonstrated in isolated nuclei from uv-irradiated human cells. Nuclei are incubated in a mixture containing [ 3 H]thymidine triphosphate and bromodeoxyuridine triphosphate in a 1:5 ratio. The 3 H at the density of parental DNA in alkaline CsCl density gradients is then a measure of repair. In nuclei prepared from WI38 cells 30 min after irradiation, repair replication is uv-dependent and proceeds at approximately the in vivo rate for 5 min. Repair replication is reduced in irradiated nuclei or in nuclei prepared immediately after irradiation. It is Mg 2+ -dependent and stimulated by added ATP and deoxyribonucleoside triphosphates. No repair replication is observed in nuclei from xeroderma pigmentosum (complementation group A) cells. However, upon addition of coliphage T4 endonuclease V, which specifically nicks DNA containing pyrimidine dimers, repair replication is observed in nuclei from irradiated xeroderma pigmentosum cells and is stimulated in WI38 nuclei. The reaction then persists for an hour and is dependent upon added ATP and deoxyribonucleoside triphosphates. The repair label is in stretches of roughly 35 nucleotides, as it is in intact cells. Added pancreatic DNase does not promote uv-dependent repair synthesis. Our results support the view that xeroderma pigmentosum (group A) cells are defective in the incision step of the DNA excision repair pathway, and demonstrate the utility of this system for probing DNA repair mechanisms

  12. DNA-content in isolated nuclei of postembryonic stages of progeny from normal and irradiated males of Tetranychus urticae (Acari Tetranychidoe)

    International Nuclear Information System (INIS)

    Tempelaar, M.J.

    1980-01-01

    The lC DNA-content of isolated nuclei of postembryonic stages of Tetranychus urticae stained with the classic and a modified Schiff's reagent was cytophotometrically estimated as 0.1 pg, a low value in animals. For many tissues of this arrhenotokus species the ploidy ratio between males and females is 1:2, indicating the absence of sex-related differences in ploidy. In addition, DNA measurements were performed to evaluate irradiation-experiments, starting with X-irradiation of mature sperm in males with doses known from previous work to induce chromosomal fragments that are subject to loss and missegregation in the embryonic mitotic stages of the female progeny despite the presumed holokinetic nature of the chromosomes. The DNA-content of the nuclei of the surviving postembryonic preadult stages did not indicate the occurrence of nuclei with in-between male/female values, ruling out loss and missegregation of fragments as important factors in postembryonic lethality. Abnormally low DNA-values in some adult females could be attributed to development of embryos before oviposition caused by radiation-induced effects. (orig.) [de

  13. Conditioned same-sex partner preference in male rats is facilitated by oxytocin and dopamine: effect on sexually dimorphic brain nuclei.

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    Triana-Del Rio, Rodrigo; Tecamachaltzi-Silvarán, Miriam B; Díaz-Estrada, Victor X; Herrera-Covarrubias, Deissy; Corona-Morales, Aleph A; Pfaus, James G; Coria-Avila, Genaro A

    2015-04-15

    Conditioned same-sex partner preference can develop in male rats that undergo cohabitation under the effects of quinpirole (QNP, D2 agonist). Herein, we assessed the development of conditioned same-sex social/sexual preference in males that received either nothing, saline, QNP, oxytocin (OT), or QNP+OT during cohabitation with another male (+) or single-caged (-). This resulted in the following groups: (1) Intact-, (2) Saline+, (3) QNP-, (4) OT-, (5) QNP+, (6) OT+ and (7) QNP/OT+. Cohabitation occurred during 24h in a clean cage with a male partner that bore almond scent on the back as conditioned stimulus. This was repeated every 4 days for a total of three trials. Social and sexual preference were assessed four days after the last conditioning trial in a drug-free test in which experimental males chose between the scented familiar male and a novel sexually receptive female. Results showed that males from groups Intact-, Saline+, QNP- and OT- displayed a clear preference for the female (opposite-sex), whereas groups QNP+, OT+ and QNP/OT+ displayed socio/sexual preference for the male partner (same-sex). In Experiment 2, the brains were processed for Nissl dye and the area size of two sexually dimorphic nuclei (SDN-POA and SON) was compared between groups. Males from groups OT-, OT+ and QNP/OT+ expressed a smaller SDN-POA and groups QNP+ and QNP/OT+ expressed a larger SON. Accordingly, conditioned same-sex social/sexual partner preference can develop during cohabitation under enhanced D2 or OT activity but such preference does not depend on the area size of those sexually dimorphic nuclei. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. Pseudomagic nuclei

    International Nuclear Information System (INIS)

    Scharff-Goldhaber, G.

    1979-01-01

    It was shown previously that, below a critical angular momentum, yrast bands of nonmagic nuclei are well described by the two-parameter variable moment of inertia model. Some striking exceptions to this rule are found in nuclei which have the same mass number as doubly magic nuclei but possess either one (or two) proton pairs beyond a magic number and one (or two) neutron hole pairs, or vice versa. Yrast bands in these pseudomagic nuclei resemble those in magic nuclei. 17 references

  15. Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles.

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    Johnson, Zachary V; Walum, Hasse; Jamal, Yaseen A; Xiao, Yao; Keebaugh, Alaine C; Inoue, Kiyoshi; Young, Larry J

    2016-03-01

    Oxytocin (OT) is a deeply conserved nonapeptide that acts both peripherally and centrally to modulate reproductive physiology and sociosexual behavior across divergent taxa, including humans. In vertebrates, the distribution of the oxytocin receptor (OTR) in the brain is variable within and across species, and OTR signaling is critical for a variety of species-typical social and reproductive behaviors, including affiliative and pair bonding behaviors in multiple socially monogamous lineages of fishes, birds, and mammals. Early work in prairie voles suggested that the endogenous OT system modulates mating-induced partner preference formation in females but not males; however, there is significant evidence that central OTRs may modulate pair bonding behavior in both sexes. In addition, it remains unclear how transient windows of central OTR signaling during sociosexual interaction modulate neural activity to produce enduring shifts in sociobehavioral phenotypes, including the formation of selective social bonds. Here we re-examine the role of the central OT system in partner preference formation in male prairie voles using a selective OTR antagonist delivered intracranially. We then use the same antagonist to examine how central OTRs modulate behavior and immediate early gene (Fos) expression, a metric of neuronal activation, in males during brief sociosexual interaction with a female. Our results suggest that, as in females, OTR signaling is critical for partner preference formation in males and enhances correlated activation across sensory and reward processing brain areas during sociosexual interaction. These results are consistent with the hypothesis that central OTR signaling facilitates social bond formation by coordinating activity across a pair bonding neural network. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles

    Science.gov (United States)

    Johnson, Zachary V.; Walum, Hasse; Jamal, Yaseen A.; Xiao, Yao; Keebaugh, Alaine C.; Inoue, Kiyoshi; Young, Larry J.

    2016-01-01

    Oxytocin (OT) is a deeply conserved nonapeptide that acts both peripherally and centrally to modulate reproductive physiology and sociosexual behavior across divergent taxa, including humans. In vertebrates, the distribution of the oxytocin receptor (OTR) in the brain is variable within and across species, and OTR signaling is critical for a variety of species-typical social and reproductive behaviors, including affiliative and pair bonding behaviors in multiple socially monogamous lineages of fishes, birds, and mammals. Early work in prairie voles suggested that the endogenous OT system modulates mating-induced partner preference formation in females but not males; however, there is significant evidence that central OTRs may modulate pair bonding behavior in both sexes. In addition, it remains unclear how transient windows of central OTR signaling during sociosexual interaction modulate neural activity to produce enduring shifts in sociobehavioral phenotypes, including the formation of selective social bonds. Here we re-examine the role of the central OT system in partner preference formation in male prairie voles using a selective OTR antagonist delivered intracranially. We then use the same antagonist to examine how central OTRs modulate behavior and immediate early gene (Fos) expression, a metric of neuronal activation, in males during brief sociosexual interaction with a female. Our results suggest that, as in females, OTR signaling is critical for partner preference formation in males and enhances correlated activation across sensory and reward processing brain areas during sociosexual interaction. These results are consistent with the hypothesis that central OTR signaling facilitates social bond formation by coordinating activity across a pair bonding neural network. PMID:26643557

  17. Dietary Manipulations That Induce Ketosis Activate the HPA Axis in Male Rats and Mice: A Potential Role for Fibroblast Growth Factor-21.

    Science.gov (United States)

    Ryan, Karen K; Packard, Amy E B; Larson, Karlton R; Stout, Jayna; Fourman, Sarah M; Thompson, Abigail M K; Ludwick, Kristen; Habegger, Kirk M; Stemmer, Kerstin; Itoh, Nobuyuki; Perez-Tilve, Diego; Tschöp, Matthias H; Seeley, Randy J; Ulrich-Lai, Yvonne M

    2018-01-01

    In response to an acute threat to homeostasis or well-being, the hypothalamic-pituitary-adrenocortical (HPA) axis is engaged. A major outcome of this HPA axis activation is the mobilization of stored energy, to fuel an appropriate behavioral and/or physiological response to the perceived threat. Importantly, the extent of HPA axis activity is thought to be modulated by an individual's nutritional environment. In this study, we report that nutritional manipulations signaling a relative depletion of dietary carbohydrates, thereby inducing nutritional ketosis, acutely and chronically activate the HPA axis. Male rats and mice maintained on a low-carbohydrate high-fat ketogenic diet (KD) exhibited canonical markers of chronic stress, including increased basal and stress-evoked plasma corticosterone, increased adrenal sensitivity to adrenocorticotropin hormone, increased stress-evoked c-Fos immunolabeling in the paraventricular nucleus of the hypothalamus, and thymic atrophy, an indicator of chronic glucocorticoid exposure. Moreover, acutely feeding medium-chain triglycerides (MCTs) to rapidly induce ketosis among chow-fed male rats and mice also acutely increased HPA axis activity. Lastly, and consistent with a growing literature that characterizes the hepatokine fibroblast growth factor-21 (FGF21) as both a marker of the ketotic state and as a key metabolic stress hormone, the HPA response to both KD and MCTs was significantly blunted among mice lacking FGF21. We conclude that dietary manipulations that induce ketosis lead to increased HPA axis tone, and that the hepatokine FGF21 may play an important role to facilitate this effect. Copyright © 2018 Endocrine Society.

  18. Exotic nuclei

    International Nuclear Information System (INIS)

    Villari, A.C.C.

    1990-01-01

    The actual tendencies to study exotic nuclei; applications of exotic nuclei beams in material study and medicine; recent results obtained by GANIL and Berkeley Laboratories of measurements of binding energy and radii of light nuclei; the future experiences to be carry out in several international laboratories and; proposal of studies in Brazil using Pelletron-USP accelerator and the LINAC superconductor accelerator, in construction in the same laboratory, are presented. (M.C.K.)

  19. Fibroblastic rheumatism

    Directory of Open Access Journals (Sweden)

    Jyoti Ranjan Parida

    2017-01-01

    Full Text Available Fibroblastic rheumatism (FR is a rare dermoarthopathy reported from different parts of the world since 1980. Although the exact cause is unknown, few reports implicate infection may be a triggering event. Patients usually present with multiple skin nodules and polyarthropathy with progressive skin contractures. Laboratory parameters including acute phase reactants are usually normal. The confirmatory diagnosis is based on histopathologic study of skin nodules, which demonstrate fibroblastic proliferation, thickened collagen fibers, dermal fibrosis, and decreased number of elastic fibers. Immunoreactivity for b-catenin, smooth muscle actin, and the monoclonal antibody HHF35 show myofibroblastic differentiation. Treatments with oral prednisolone and other disease-modifying drugs such as methotrexate, infliximab, and interferon have been tried with variable success. In general, skin lesions respond more aptly than joint symptoms indicating that skin fibroblast is more amenable to treatment than synovial fibroblasts. Awareness regarding this orphan disease among clinicians and pathologists will help in more reporting of such cases and finding out optimal treatment regimen.

  20. Superdeformed nuclei

    International Nuclear Information System (INIS)

    Janssens, R.V.F.; Khoo, T.L.

    1991-01-01

    Superdeformation was first proposed some twenty years ago to explain the fission isomers observed in some actinide nuclei. It was later realized that superdeformed shapes can occur at high angular momentum in lighter nuclei. The interest in the mechanisms responsible for these exotic shapes has increased enormously with the discovery of a superdeformed band of nineteen discrete lines in 152 Dy (8). At about the same time, evidence for highly deformed nuclei (axis ratio 3:2) was also reported near 132 Ce(9). Striking properties emerged from the first experiments, such as the essentially constant energy spacing between transitions (picket-fence spectra), the unexpectedly strong population of superdeformed bands at high spins, and the apparent lack of a link between the superdeformed states and the yrast levels. These findings were reviewed by Nolan and Twin. The present article follows upon their work and discusses the wealth of information that has since become available. This includes the discovery of a new island of superdeformation near A = 190, the detailed spectroscopy of ground and excited bands in the superdeformed well near A = 150 and A = 190, the surprising occurrence of superdeformed bands with identical transition energies in nuclei differing by one or two mass units, and the improved understanding of mechanisms responsible for the feeding into and the decay out of the superdeformed states

  1. Attention and Motivated Response to Simulated Male Advertisement Call Activates Forebrain Dopaminergic and Social Decision-Making Network Nuclei in Female Midshipman Fish.

    Science.gov (United States)

    Forlano, Paul M; Licorish, Roshney R; Ghahramani, Zachary N; Timothy, Miky; Ferrari, Melissa; Palmer, William C; Sisneros, Joseph A

    2017-10-01

    Little is known regarding the coordination of audition with decision-making and subsequent motor responses that initiate social behavior including mate localization during courtship. Using the midshipman fish model, we tested the hypothesis that the time spent by females attending and responding to the advertisement call is correlated with the activation of a specific subset of catecholaminergic (CA) and social decision-making network (SDM) nuclei underlying auditory- driven sexual motivation. In addition, we quantified the relationship of neural activation between CA and SDM nuclei in all responders with the goal of providing a map of functional connectivity of the circuitry underlying a motivated state responsive to acoustic cues during mate localization. In order to make a baseline qualitative comparison of this functional brain map to unmotivated females, we made a similar correlative comparison of brain activation in females who were unresponsive to the advertisement call playback. Our results support an important role for dopaminergic neurons in the periventricular posterior tuberculum and ventral thalamus, putative A11 and A13 tetrapod homologues, respectively, as well as the posterior parvocellular preoptic area and dorsomedial telencephalon, (laterobasal amygdala homologue) in auditory attention and appetitive sexual behavior in fishes. These findings may also offer insights into the function of these highly conserved nuclei in the context of auditory-driven reproductive social behavior across vertebrates. © The Author 2017. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

  2. Colliding nuclei

    International Nuclear Information System (INIS)

    Balian, Roger; Remaud, Bernard; Suraud, E.; Durand, Dominique; Tamain, Bernard; Gobbi, A.; Cugnon, J.; Drapier, Olivier; Govaerts, Jan; Prieels, Rene

    1995-09-01

    This 14. international school Joliot-Curie of nuclear physic deals with nuclei in collision at high energy. Nine lectures are included in the proceedings of this summer school: 1 - From statistical mechanics outside equilibrium to transport equations (Balian, R.); 2 - Modeling of heavy ions reactions (Remaud, B.); 3 - Kinetic equations in heavy ions physics (Suraud, E.); 4 - Colliding nuclei near the Fermi energy (Durand, D.; Tamain, B.); 5 - From the Fermi to the relativistic energy domain: which observable? For which physics? (Gobbi, A.); 6 - Collisions at relativistic and ultra relativistic energies, Theoretical aspects (Cugnon, J.); 7 - Quark-gluon plasma: experimental signatures (Drapier, O.); 8 - Electroweak interaction: a window on physics beyond the standard model (Govaerts, J.); 9 - Symmetry tests in β nuclear process: polarization techniques (Prieels, R.)

  3. Primordial nuclei

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    The recent detection of intergalactic helium by NASA's Astro-2 mission backs up two earlier measurements by ESA and the University of California, San Diego, using instruments aboard the Hubble Space Telescope. Taken together, these results give strong evidence that this helium is primordial, confirming a key prediction of the Big Bang theory. The amount of helium the results imply could also account for some of the Universe's invisible dark matter - material which affects galactic motion but is otherwise undetectable. According to theory, helium nuclei formed at around 100 seconds after the Big Bang, but the amount of helium depended on even earlier events. Initially, protons turned into neutrons with the same probability that neutrons turned into protons. But after about one second, the Universe had cooled down enough for the weak interaction to freeze out. Neutrons continued to decay into the slightly lighter protons, whilst the opposite reaction became much more scarce. At around 100 seconds, thermonuclear fusion reactions could begin, and all the neutrons that were left became absorbed into helium nuclei, leaving the remaining protons locked up in hydrogen. The ratio of helium to hydrogen was therefore determined by events occurring when the Universe was just one second old. Standard models of primordial nucleosynthesis fix this ratio at slightly less than 2 5% by mass. All heavier elements were cooked up much later in the stars, and amount to less than 1 % of the Universe's mass. These predictions have been borne out remarkably well by observation, although proof of the primordial origins of hydrogen and helium has remained elusive until now. Big Bang nucleosynthesis goes on to estimate that primordial baryonic matter in the form of light nuclei could account for around 10% of the Universe's dark matter. All three recent measurements used the same technique of looking at distant quasars, some of the most luminous objects in the Universe, to

  4. Calorimetric signatures of human cancer cells and their nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Todinova, S. [Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, Sofia 1113 (Bulgaria); Stoyanova, E. [Department of Molecular Immunology, Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Tzarigradsko shose Blvd. 73, Sofia 1113 (Bulgaria); Krumova, S., E-mail: sakrumo@gmail.com [Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, Sofia 1113 (Bulgaria); Iliev, I. [Institute of Experimental Morphology, Pathology and Anthropology with Museum, Acad. G. Bonchev Str., Bl. 25, Sofia 1113 (Bulgaria); Taneva, S.G. [Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, Sofia 1113 (Bulgaria)

    2016-01-10

    Graphical abstract: - Highlights: • Two temperature ranges are distinguished in the thermograms of cells/nuclei. • Different thermodynamic properties of cancer and normal human cells/nuclei. • Dramatic reduction of the enthalpy of the low-temperature range in cancer cells. • Oxaliplatin and 5-FU affect the nuclear matrix proteins and the DNA stability. - Abstract: The human cancer cell lines HeLa, JEG-3, Hep G2, SSC-9, PC-3, HT-29, MCF7 and their isolated nuclei were characterized by differential scanning calorimetry. The calorimetric profiles differed from normal human fibroblast (BJ) cells in the two well distinguished temperature ranges—the high-temperature range (H{sub T}, due to DNA-containing structures) and the low-temperature range (L{sub T}, assigned to the nuclear matrix and cellular proteins). The enthalpy of the L{sub T} range, and, respectively the ratio of the enthalpies of the L{sub T}- vs. H{sub T}-range, ΔH{sub L}/ΔH{sub H}, is strongly reduced for all cancer cells compared to normal fibroblasts. On the contrary, for most of the cancer nuclei this ratio is higher compared to normal nuclei. The HT-29 human colorectal cancer cells/nuclei differed most drastically from normal human fibroblast cells/nuclei. Our data also reveal that the treatment of HT-29 cancer cells with cytostatic drugs affects not only the DNA replication but also the cellular proteome.

  5. Collagen expression in fibroblasts with a novel LMNA mutation

    International Nuclear Information System (INIS)

    Nguyen, Desiree; Leistritz, Dru F.; Turner, Lesley; MacGregor, David; Ohson, Kamal; Dancey, Paul; Martin, George M.; Oshima, Junko

    2007-01-01

    Laminopathies are a group of genetic disorders caused by LMNA mutations; they include muscular dystrophies, lipodystrophies, and progeroid syndromes. We identified a novel heterozygous LMNA mutation, L59R, in a patient with the general appearance of mandibuloacral dysplasia and progeroid features. Examination of the nuclei of dermal fibroblasts revealed the irregular morphology characteristic of LMNA mutant cells. The nuclear morphological abnormalities of LMNA mutant lymphoblastoid cell lines were less prominent compared to those of primary fibroblasts. Since it has been reported that progeroid features are associated with increased extracellular matrix in dermal tissues, we compared a subset of these components in fibroblast cultures from LMNA mutants with those of control fibroblasts. There was no evidence of intracellular accumulation or altered mobility of collagen chains, or altered conversion of procollagen to collagen, suggesting that skin fibroblast-mediated matrix production may not play a significant role in the pathogenesis of this particular laminopathy

  6. Fibroblast Growth Factor 21 (FGF21, Free Fatty Acid (FFA, High Sensitivity C-reactive Protein (hsCRP and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR Among Indonesian Obese Non-Diabetic Males

    Directory of Open Access Journals (Sweden)

    Yani Lina

    2009-12-01

    Full Text Available BACKGROUND: Fibroblast growth factor-21 (FGF21 is known as an important endocrine and paracrine regulator of metabolic homeostasis. Recent studies have shown that FGF21 attenuates lipolysis in human adipocytes, which is suggested as a FGF21's mechanism as anti-hyperlipidemia, anti-hyperglycemia and anti-obesity. The aim of this study was to measure the correlation between FGF21, FFA, hsCRP and HOMA-IR among Indonesian obese non diabetic males. METHODS: The study was observational with cross sectional design. The analysis was done in 137 subjects aged 30-60 years with non diabetic abdominal obesity. We measured the biochemical markers FGF21, FFA, hsCRP, fasting insulin and fasting glucose. We also measured weight, height, waist circumrefence (WC, creatinine, serum glutamin oxaloacetic transaminase (SGOT, and serum glutamic pyruvic transaminase (SGPT, systolic blood pressure (SBP and diastolic blood pressure (DBP. Correlation between markers was measured using Pearson and Spearman's analysis. RESULTS: There were significant positive correlations between FGF21-HOMA-IR (r=0.314, p=0.000; FGF21-WC (r=0.173, p=0.043; FFA=hsCRP r=0.270, p=0.001; and WC-HOMA-IR (r=0.279, p=0.001. There was significant negative correlation between FGF21-FFA (r=-0.038, p=0.657 and FGF21-hsCRP (r=-0.061, p=0.482. CONCLUSIONS: In this study we found that although there was no significant correlation, FGF21 might act as an anti-lipolytic and anti-inflammation agent among Indonesian obese non-diabetic males. Our findings agree with results of previous studies that the positive correlation between FGF21-WC and FGF21-HOMA-IR might occur as a compensatory mechanism or resistance to FGF21 in obesity. KEYWORDS: obesity, FGF21, FFA, hsCRP, HOMA-IR.

  7. Studies of exotic nuclei

    International Nuclear Information System (INIS)

    Angelique, J.C.; Orr, N.A.

    1997-01-01

    The study of the nuclei far off stability valley is of much interest for testing the nuclear models established for the stable nuclei but also for astrophysics to understand the nucleosynthesis. Experiments aim to measure the mass and lifetime, to build the decay schemes and also to study the structure and the properties of these nuclei. The radioactive beam group focused its research on light neutron-rich nuclei having a halo neutron structure. Mass measurements in N ∼ Z nuclei namely in A ∼ 60-80 proton-rich nuclei, important for understanding the rp process, are mentioned, as well as in nuclei in the 100 Sn region. In the newly obtained 26 O and 28 O nuclei the lifetimes, the probabilities of emission of one for more neutrons were determined. The data analysis has permitted to determine also for the first time the lifetimes of 27,29 F and 30 Ne. Studies of nuclei in the 100 Sn region, near the proton drip line in the ground and isomeric states are now under way. The spectroscopy (energy levels, gamma emissions, etc.) of the neutron-rich nuclei produced by the 36 S fragmentation has been carried out in 31 Ne, 17 B and 29 F. Studies by Coulomb excitation of the 2 + excited states and associated probability B (E2) in O, Ne, Ni and Zn are now analysed

  8. Nuclei and quantum worlds

    International Nuclear Information System (INIS)

    Chomaz, Ph.

    2000-01-01

    This document gathers the slides and their commentaries that have been presented at the conference 'physics and fundamental questions' by P. Chomaz. The author reviews the different quantum aspects of nuclei: tunnel effect, symmetries, magic numbers, wave functions, size, shapes and deformations. The author shows that nuclei are quantum objects of great complexity, their structures are not yet well understood and the study of exotic nuclei will continue bringing valuable information

  9. Pairing correlations in nuclei

    International Nuclear Information System (INIS)

    Baba, C.V.K.

    1988-01-01

    There are many similarities between the properties of nucleons in nuclei and electrons in metals. In addition to the properties explainable in terms of independent particle motion, there are many important co-operative effects suggesting correlated motion. Pairing correlation which leads to superconductivity in metals and several important properties in nuclei , is an exmple of such correlations. An attempt has been made to review the effects of pairing correlations in nuclei. Recent indications of reduction in pairing correlations at high angular momenta is discussed. A comparision between pairing correlations in the cases of nuclei and electrons in metals is attempted. (author). 20 refs., 10 figs

  10. Nuclei with exotic constituents

    International Nuclear Information System (INIS)

    Yamazaki, Toshimitsu.

    1990-08-01

    We discuss various interesting features in the behavior of exotic constituents of nuclei such as hyperons and mesons, in particular, with emphases on the aspect of exotic halos which are formed in general by short-range repulsion and long-range attraction. Specifically, Λ and Σ hypernuclei and pionic nuclei are discussed. (author)

  11. Neutron rich nuclei

    International Nuclear Information System (INIS)

    Foucher, R.

    1979-01-01

    If some β - emitters are particularly interesting to study in light, medium, and heavy nuclei, another (and also) difficult problem is to know systematically the properties of these neutron rich nuclei far from the stability line. A review of some of their characteristics is presented. How far is it possible to be objective in the interpretation of data is questioned and implications are discussed

  12. Baryon resonances in nuclei

    International Nuclear Information System (INIS)

    Arenhoevel, H.

    1977-01-01

    The field of baryon resonances in nuclei is reviewed. Theoretical developments and experimental evidence as well are discussed. Special emphasis is laid on electromagnetic processes for the two nucleon system. Some aspects of real isobars in nuclei are touched upon. (orig.) [de

  13. Nuclei in high forms

    International Nuclear Information System (INIS)

    Szymanski, Z.; Berger, J.F.; Heenen, P.H.; Heyde, K.; Haas, B.; Janssens, R.; Paya, D.; Gogny, D.; Huber, G.; Bjoernholm, S.; Brack, M.

    1991-01-01

    The purpose of 1991 Joliot-Curie Summer School is to review the most advances in the understanding of the nuclei physics after the considerable progress in gamma spectroscopy. It covers the following topics: Highly and super-deformed nuclei, nuclear structures, mean-field approach and beyond, fission isomers, nuclear excitations with long lifetime and metal clusters

  14. Pair correlations in nuclei

    International Nuclear Information System (INIS)

    Shimizu, Yoshifumi

    2009-01-01

    Except for the closed shell nuclei, almost all nuclei are in the superconducting state at their ground states. This well-known pair correlation in nuclei causes various interesting phenomena. It is especially to be noted that the pair correlation becomes weak in the excited states of nuclei with high angular momentum, which leads to the pair phase transition to the normal state in the high spin limit. On the other hand, the pair correlation becomes stronger in the nuclei with lower nucleon density than in those with normal density. In the region of neutron halo or skin state of unstable nuclei, this phenomenon is expected to be further enhanced to be observed compared to the ground state of stable nuclei. An overview of those interesting aspects caused via the pair correlation is presented here in the sections titled 'pair correlations in ground states', pair correlations in high spin states' and 'pair correlations in unstable nuclei' focusing on the high spin state. (S. Funahashi)

  15. Eta mesons in nuclei

    International Nuclear Information System (INIS)

    Liu, L.C.

    1987-01-01

    The possibility of producing eta-mesic nuclei by the use of pions is discussed. If these nuclei are observed experimentally, then the binding energies of the eta in this new nuclear matter can be used to extract accurately the eta-N-N* coupling constant in a nucleus. The framework for these calculations is the coupled channel isobar model

  16. Fibroblast growth factor 23

    African Journals Online (AJOL)

    Dr Olaleye

    Systemic phosphate homeostasis is maintained through several hormonal mechanisms which involve fibroblast growth factor 23 (FGF-23), α-klotho, vitamin D and parathyroid hormone. FGF-23 is known to be the major regulator of phosphate balance (Mirams et al., 2004). FGF-23 is a phosphaturic hormone, which is.

  17. Nucleons in nuclei, however

    International Nuclear Information System (INIS)

    Grange, P.; Mathiot, J.F.; Roy-Stephan, M.; Frascaria, R.; Gales, S.

    1990-01-01

    The topics presented at the 1989 Joliot-Curie Lectures are reported. Two main subjects were retained: a simplified description of the N-body motion of particles in the quasi-particle configuration; study of the dynamics of nuclear components which are not described by nucleons in their ground state. The following themes were presented: quasiparticles and the Green functions, relativistic aspects of the quasiparticle concept, the dimensions of nucleons in the nuclei and the EMC effect, quarks and gluons in the nuclei, the delta in the nuclei, the strangeness, quasiparticles far from the Fermi sea, diffusion of electrons, stellar evolution and nucleosynthesis [fr

  18. Dynamic polarisation of nuclei

    International Nuclear Information System (INIS)

    Borghini, M.; Abragam, A.

    1961-01-01

    In magnetic fields of about 13000 gauss, at a temperature of 1.5 deg. K, in samples of about 2 mm 3 , we have obtained by the 'solid effect' (application of a magnetic field at an appropriate frequency around 35000 MHz), nuclear polarizations /I of a few percent: 19 per cent for hydrogen nuclei in single crystals of La 2 Mg 3 (NO 3 ) 12 , 24H 2 O; 5 per cent for hydrogen nuclei in polystyrene; 6 per cent for fluorine nuclei in single crystals of LiF. (author) [fr

  19. Quarks in nuclei

    International Nuclear Information System (INIS)

    Roberts, R.G.

    1984-11-01

    The paper concerns the behaviour of quarks in nuclei. Confinement size changes and dynamical rescaling; A dependence; low-x region; gluons and confinement size; and nucleons in a nucleus; are all discussed. (U.K.)

  20. The shape of nuclei

    International Nuclear Information System (INIS)

    Mackintosh, R.S.

    1977-01-01

    For the class of nuclei which are 'strongly deformed' it is possible to introduce the idea of an empirically measurable static nuclear shape. The limitations of this concept as applied to nuclei (fundamentally quantum-mechanical objects) are discussed. These are basically the limitations of the rotational model which must be introduced in order to define and measure nuclear shape. A unified discussion of the ways in which the shape has been parametrized is given with emphasis on the fact that different parametrizations correspond to different nuclear structures. Accounts of the various theoretical procedures for calculating nuclear shapes and of the interaction between nuclear shapes and nuclear spectroscopy are given. A coherent account of a large subset of nuclei (strongly deformed nuclei) can be given by means of a model in which the concept of nuclear shape plays a central role. (author)

  1. Structure of Warm Nuclei

    International Nuclear Information System (INIS)

    Aaberg, S.; Uhrenholt, H.

    2009-01-01

    We study the structure of nuclei in the energy region between the ground state and the neutron separation energy, here called warm nuclei. The onset of chaos in the nucleus as excitation energy is increased is briefly reviewed. Chaos implies fluctuations of energies and wave functions qualitatively the same for all chaotic nuclei. On the other hand, large structure effects are seen, e.g. in the level-density function at same excitation energies. A microscopic model for the level density is reviewed and we discuss effects on structure of the total level-density function, parity enhancement, and the spin distribution function. Comparisons to data are performed at the neutron separation energy for all observed nuclei, and structure of the level-density function for a few measured cases. The role of structure effects in the level-density function for fission dynamics is exemplified.

  2. Hot nuclei and fragmentation

    International Nuclear Information System (INIS)

    Guerreau, D.

    1993-01-01

    A review is made of the present status concerning the production of nuclei above 5 MeV temperature. Considerable progress has been made recently on the understanding of the formation and the fate of such hot nuclei. It appears that the nucleus seems more stable against temperature than predicted by static calculations. However, the occurrence of multifragment production at high excitation energies is now well established. The various experimental features of the fragmentation process are discussed. (author) 59 refs., 12 figs

  3. Quantitative assessment of changes in the dermal fibroblast population of pig skin after single doses of X-rays

    Energy Technology Data Exchange (ETDEWEB)

    Hamlet, R.; Hopewell, J.W.

    1988-10-01

    Changes in the density of fibroblast nuclei in reticular dermis of pigs was studied from 6 to 104 weeks after a single dose of 15.4 Gy of X-rays. The largest decrease in fibroblasts occurred between 12 and 26 weeks after irradiation; after this there was only a slight fall in fibroblast number until 104 weeks when observations ceased. At 26 weeks and later times after irradiation reduction in the density of fibroblast nuclei in the reticular dermis was dose-dependent for single doses in the range 8.0-20.7 Gy. The dose-response curve had an initial shoulder, after which the fall in the fibroblast nuclear density was linearly related to dose. Data obtained between 26 weeks and 104 weeks after irradiation, could be fitted by the same dose-response curve. The fall in the counts of fibroblast nuclei was compared with earlier studies. The loss of fibroblasts occurred after an initial reduction in blood flow in the pig skin but was concomitant with general reduction in dermal thickness.

  4. A quantitative assessment of changes in the dermal fibroblast population of pig skin after single doses of X-rays

    International Nuclear Information System (INIS)

    Hamlet, R.; Hopewell, J.W.

    1988-01-01

    Changes in the density of fibroblast nuclei in reticular dermis of pigs was studied from 6 to 104 weeks after a single dose of 15.4 Gy of X-rays. The largest decrease in fibroblasts occurred between 12 and 26 weeks after irradiation; after this there was only a slight fall in fibroblast number until 104 weeks when observations ceased. At 26 weeks and later times after irradiation reduction in the density of fibroblast nuclei in the reticular dermis was dose-dependent for single doses in the range 8.0-20.7 Gy. The dose-response curve had an initial shoulder, after which the fall in the fibroblast nuclear density was linearly related to dose. Data obtained between 26 weeks and 104 weeks after irradiation, could be fitted by the same dose-response curve. The fall in the counts of fibroblast nuclei was compared with earlier studies. The loss of fibroblasts occurred after an initial reduction in blood flow in the pig skin but was concomitant with general reduction in dermal thickness. (author)

  5. Multifragmentation of hot nuclei

    International Nuclear Information System (INIS)

    Tamain, B.

    1990-10-01

    It is difficult to deposit a large amount (∼ 1 Gev) of excitation energy into a nucleus. And if one wants to deposit large excitation energy values, the best way consists of shooting a given target nucleus with several nucleons, which can be achieved by using intermediate energy (10-100 MeV/nucleon) heavy ions. Such very excited objects were named hot nuclei. The study of hot nuclei has been undertaken only for 7 years because intermediate energy heavy ion facilities were not available before. The game is then to determine the decay properties of such nuclei, their limits of existence. Their study is connected with general properties of nuclear matter: namely its equation of state. Of special interest, is the onset of a new decay mechanism: multifragmentation, which is the non-sequential disassembly of a hot nucleus into several light nuclei (often called intermediate-mass fragments or IMF) or particles. This paper, shows how this mechanism can reflect fundamental properties of nuclear matter, but also how its experimental signature is difficult to establish. Multifragmentation has also been studied by using very energetic projectiles (protons and heavy ions) in the relativistic or ultra-relativistic region. The multifragmentation question of hot nuclei is far from being solved. One knows that IMF production increases when the excitation energy brought into a system is strongly increased, but very little is known about the mechanisms involved and a clear onset for multifragmentation is not established

  6. Cosmology and unstable nuclei

    International Nuclear Information System (INIS)

    Schramm, D.N.

    1995-01-01

    Primordial nucleosynthesis has established itself as one of the three pillars of Big Bang cosmology. Many of the Big Bang Nucleosynthesis reactions involve unstable nuclei. Hence there is a tight relationship hetween the subject of this conference and cosmology. The prime role of unstable nuclei in cosmology is related to lithium synthesis and the lack of cosmological synthesis of Be and B. These nuclei will thus be focused upon. Nucleosynthesis involves comparing calculated abundances with observed abundances. In general, abundance determinations are dominated by systematic rather than statistical errors, and work on bounding systematics is crucial. The quark-hadron inspired inhomogeneous calculations now unanimously agree that only relatively small variations in Ω b are possible vis-a-vis the homogeneous model; hence the robustness of Ω b ∼0.05 is now apparent. (These calculations depend critically on unstable nuclei.) The above argues that the bulk of the baryons in the universe are not producing visible light. A comparison with the ROSAT cluster data is also shown to be consistent with the standard BBN model. Ω b ∼1 seems to be definitely excluded, so if Ω TOTAL =1, as some recent observations may hint, then non-baryonic dark matter is required. The implications of the recently reported halo microlensing events are discussed. In summary, it is argued that the physics of unstable nuclei affects the fundamental dark matter argument. ((orig.))

  7. Critical-point nuclei

    International Nuclear Information System (INIS)

    Clark, R.M.

    2004-01-01

    It has been suggested that a change of nuclear shape may be described in terms of a phase transition and that specific nuclei may lie close to the critical point of the transition. Analytical descriptions of such critical-point nuclei have been introduced recently and they are described briefly. The results of extensive searches for possible examples of critical-point behavior are presented. Alternative pictures, such as describing bands in the candidate nuclei using simple ΔK = 0 and ΔK = 2 rotational-coupling models, are discussed, and the limitations of the different approaches highlighted. A possible critical-point description of the transition from a vibrational to rotational pairing phase is suggested

  8. Weak interactions with nuclei

    International Nuclear Information System (INIS)

    Walecka, J.D.

    1983-01-01

    Nuclei provide systems where the strong, electomagnetic, and weak interactions are all present. The current picture of the strong interactions is based on quarks and quantum chromodynamics (QCD). The symmetry structure of this theory is SU(3)/sub C/ x SU(2)/sub W/ x U(1)/sub W/. The electroweak interactions in nuclei can be used to probe this structure. Semileptonic weak interactions are considered. The processes under consideration include beta decay, neutrino scattering and weak neutral-current interactions. The starting point in the analysis is the effective Lagrangian of the Standard Model

  9. Quarks in nuclei

    International Nuclear Information System (INIS)

    Rho, M.; CEA Centre d'Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette

    1983-01-01

    Some features of quark degrees of freedom in nuclei are discussed in the light of recent developments in QCD. The principal aim of this talk is to propose, and give a tentative support to, the motion that one can study through nuclear matter different facets of the vacuum structure implied by quantum chromodynamics (QCD). This will be done using the recent (exciting) results obtained in particle physics, in particular lattice gauge calculations. Relevance of this aspect of problem to quark degrees of freedom as well as meson degrees of freedom in nuclei will be discussed. (orig.)

  10. Disintegration of comet nuclei

    Science.gov (United States)

    Ksanfomality, Leonid V.

    2012-02-01

    The breaking up of comets into separate pieces, each with its own tail, was seen many times by astronomers of the past. The phenomenon was in sharp contrast to the idea of the eternal and unchangeable celestial firmament and was commonly believed to be an omen of impending disaster, especially for comets with tails stretching across half the sky. It is only now that we have efficient enough space exploration tools to see comet nuclei and even - in the particular case of small comet Hartley-2 in 2010 - to watch their disintegration stage. There are also other suspected candidates for disintegration in the vast family of comet nuclei and other Solar System bodies.

  11. Particles and nuclei, letters

    International Nuclear Information System (INIS)

    2002-01-01

    The present collection of letters from JINR, Dubna, contains seven separate records on kinematic separation and mass analysis of heavy recoiling nuclei, dynamical effects prior to heavy ion fusion, VACTIV-DELPHI graphical dialog based program for the analysis of gamma-ray spectra, irradiation of nuclear emulsions in relativistic beams of 6 He and 3 H nuclei, optical and structural investigations of PLZT x/65/35 (x = 4, 8 %) ferroelectric ceramics irradiated by a high-current pulsed electron beam, the oscillating charge and first evidence for neutrinoless double beta decay

  12. Particles and nuclei, letters

    International Nuclear Information System (INIS)

    2001-01-01

    The present collection of letters from JINR, Dubna, contains seven separate records on physics from extra dimensions, new physics in the new millennium with GENIUS: double beta decay, dark matter, solar neutrinos, the (μ - , e + ) conversion in nuclei mediated by light Majorana neutrinos, exotic muon-to-positron conversion in nuclei: partial transition sum evaluation by using shell model, solar neutrino problem accounting for self consistent magnetohydrodynamics solution for solar magnetic fields, first neutrino observations from the Sudbury neutrino observatory and status report on BOREXINO and results of the muon-background measurements at CERN

  13. Rotational motion in nuclei

    International Nuclear Information System (INIS)

    Bohr, A.

    1976-01-01

    Nuclear structure theories are reviewed concerned with nuclei rotational motion. The development of the deformed nucleus model facilitated a discovery of rotational spectra of nuclei. Comprehensive verification of the rotational scheme and a successful classification of corresponding spectra stimulated investigations of the rotational movement dynamics. Values of nuclear moments of inertia proved to fall between two marginal values corresponding to rotation of a solid and hydrodynamic pattern of an unrotating flow, respectively. The discovery of governing role of the deformation and a degree of a symmetry violence for determining rotational degrees of freedon is pointed out to pave the way for generalization of the rotational spectra

  14. Gene targeting in adult rhesus macaque fibroblasts

    Directory of Open Access Journals (Sweden)

    Wolf Don P

    2008-03-01

    Full Text Available Abstract Background Gene targeting in nonhuman primates has the potential to produce critical animal models for translational studies related to human diseases. Successful gene targeting in fibroblasts followed by somatic cell nuclear transfer (SCNT has been achieved in several species of large mammals but not yet in primates. Our goal was to establish the protocols necessary to achieve gene targeting in primary culture of adult rhesus macaque fibroblasts as a first step in creating nonhuman primate models of genetic disease using nuclear transfer technology. Results A primary culture of adult male fibroblasts was transfected with hTERT to overcome senescence and allow long term in vitro manipulations. Successful gene targeting of the HPRT locus in rhesus macaques was achieved by electroporating S-phase synchronized cells with a construct containing a SV40 enhancer. Conclusion The cell lines reported here could be used for the production of null mutant rhesus macaque models of human genetic disease using SCNT technology. In addition, given the close evolutionary relationship and biological similarity between rhesus macaques and humans, the protocols described here may prove useful in the genetic engineering of human somatic cells.

  15. Involvement of the mitochondrial compartment in human NCL fibroblasts

    International Nuclear Information System (INIS)

    Pezzini, Francesco; Gismondi, Floriana; Tessa, Alessandra; Tonin, Paola; Carrozzo, Rosalba; Mole, Sara E.; Santorelli, Filippo M.; Simonati, Alessandro

    2011-01-01

    Highlights: ► Mitochondrial reticulum fragmentation occurs in human CLN1 and CLN6 fibroblasts. ► Likewise mitochondrial shift-to periphery and decreased mitochondrial density are seen. ► Enhanced caspase-mediated apoptosis occurs following STS treatment in CLN1 fibroblasts. -- Abstract: Neuronal ceroid lipofuscinosis (NCL) are a group of progressive neurodegenerative disorders of childhood, characterized by the endo-lysosomal storage of autofluorescent material. Impaired mitochondrial function is often associated with neurodegeneration, possibly related to the apoptotic cascade. In this study we investigated the possible effects of lysosomal accumulation on the mitochondrial compartment in the fibroblasts of two NCL forms, CLN1 and CLN6. Fragmented mitochondrial reticulum was observed in all cells by using the intravital fluorescent marker Mitotracker, mainly in the perinuclear region. This was also associated with intense signal from the lysosomal markers Lysotracker and LAMP2. Likewise, mitochondria appeared to be reduced in number and shifted to the cell periphery by electron microscopy; moreover the mitochondrial markers VDCA and COX IV were reduced following quantitative Western blot analysis. Whilst there was no evidence of increased cell death under basal condition, we observed a significant increase in apoptotic nuclei following Staurosporine treatment in CLN1 cells only. In conclusion, the mitochondrial compartment is affected in NCL fibroblasts invitro, and CLN1 cells seem to be more vulnerable to the negative effects of stressed mitochondrial membrane than CLN6 cells.

  16. Symmetries and nuclei

    International Nuclear Information System (INIS)

    Henley, E.M.

    1987-01-01

    Nuclei are very useful for testing symmetries, and for studies of symmetry breaking. This thesis is illustrated for two improper space-time transformations, parity and time-reversal and for one internal symmetry: charge symmetry and independence. Recent progress and present interest is reviewed. 23 refs., 8 figs., 2 tabs

  17. Electroweak interactions in nuclei

    International Nuclear Information System (INIS)

    Henley, E.M.

    1984-06-01

    Topics include: introduction to electroweak theory; the Weinberg-Salam theory for leptons; the Weinberg-Salam theory for hadrons-the GIM mechanism; electron scattering as a probe of the electroweak interaction (observation of PV, the weak interaction for nucleons, and parity violation in atoms); and time reversed invariance and electric dipole moments of nucleons, nuclei, and atoms. 52 references

  18. Transfer involving deformed nuclei

    International Nuclear Information System (INIS)

    Rasmussen, J.O.; Guidry, M.W.; Canto, L.F.

    1985-03-01

    Results are reviewed of 1- and 2-neutron transfer reactions at near-barrier energies for deformed nuclei. Rotational angular momentum and excitation patterns are examined. A strong tendency to populating high spin states within a few MeV of the yrast line is noted, and it is interpreted as preferential transfer to rotation-aligned states. 16 refs., 12 figs

  19. Collisions with nuclei

    International Nuclear Information System (INIS)

    Gulamov, K.G.

    1987-01-01

    It is well known that interactions of high energy particles with nuclei, owing to possible intranuclear rescatterings, may provide information about the space-time behaviour of the production process. Therefore the main goals of these investigations are related with the attempts to study the space-time process of hadronization of coloured quarks and gluons produced at the initial stage of an interaction to white final state particles and to clarify the influence of composite quark-gluon structure of both the projectile and target on features of the production mechanisms. Since in both the initial and final states of these reactions the authors have strongly interacting multiparticle systems, it is of importance to study the collective properties of these systems. The questions to the point are: what is the degree of collectivization of particles newly produced in collisions with nuclei and what is the influence of the collective nature of a nucleus itself on the production mechanisms, in particular, what are the manifestations of possible multinucleon (multiquark) configurations in nuclei? It is obvious that the reductability of, say, hadron-nucleus (hA) interaction to hadron-nucleon (hN) collisions is directly related to the above problems. Due to time limitations the author discusses here only a few aspects of low p/sub t/ hA interactions which in his opinion are of importance for better understanding of general regularities of collisions with nuclei and for further investigations of the above problems

  20. Nucleons in nuclei (II)

    International Nuclear Information System (INIS)

    Laget, J.M.

    1988-01-01

    This summary is a review of our understanding of nuclei in terms of hadrons exchanging mesons. The open problems are: the determination of the high momentum components of nuclear systems, the role of the three-body forces and the nature of the short range correlations. The ways of studying these problems are discussed

  1. Electromagnetic structure of nuclei

    International Nuclear Information System (INIS)

    Arnold, R.G.

    1986-07-01

    A brief review is given of selected topics in the electromagnetic structure of nucleons and nuclei, including nucleon form factors from both quantum chromodynamics and electron scattering data, measurements of the deuteron and triton form factors, quasi-elastic scattering, and the EMC effect. 47 refs., 13 figs

  2. Rotational motion in nuclei

    International Nuclear Information System (INIS)

    Bohr, A.

    1977-01-01

    History is surveyed of the development of the theory of rotational states in nuclei. The situation in the 40's when ideas formed of the collective states of a nucleus is evoked. The general rotation theory and the relation between the single-particle and rotational motion are briefly discussed. Future prospects of the rotation theory development are indicated. (I.W.)

  3. Mesons and light nuclei

    International Nuclear Information System (INIS)

    Truhlik, E.; Mach, R.

    1992-01-01

    62 papers and one summary talk were presented at the conference, on subject matters in between nuclear physics (mainly light nuclei) and elementary particle physics, as indicated by the session headings (1) Electroweak nuclear interaction (2) Nuclear physics with pions and antiprotons (3) Nuclear physics with strange particles (4) Relativistic nuclear physics (5) Quark degrees of freedom. (Quittner)

  4. Radii of radioactive nuclei

    International Nuclear Information System (INIS)

    Mittig, W.; Plagnol, E.; Schutz, Y.

    1989-11-01

    A new simple direct method for the measurement of the total reaction cross section (σ R ) for several light radioactive nuclei (A≤40) is developed. From that, the reduced strong absorption radii (r o 2 ) are obtained. A comparison is made with data obtained by other techniques. A strong isospin dependence of the nuclear radii is observed. (L.C.) [pt

  5. Alpha clustering in nuclei

    International Nuclear Information System (INIS)

    Hodgson, P.E.

    1990-01-01

    The effects of nucleon clustering in nuclei are described, with reference to both nuclear structure and nuclear reactions, and the advantages of using the cluster formalism to describe a range of phenomena are discussed. It is shown that bound and scattering alpha-particle states can be described in a unified way using an energy-dependent alpha-nucleus potential. (author)

  6. Particles, imaging and nuclei

    International Nuclear Information System (INIS)

    Harris, J.

    1986-01-01

    The book on particles, imaging and nuclei is one of the Background Readers for the Revised Nuffield Advanced Physics course. The contents contain five educational articles, which extend concepts covered in the course and examine recent developments in physics. Four of the articles on:- particles and the forces of nature, radioisotopes, lasers probe the atomic nucleus, and nuclear history, are indexed separately. (UK)

  7. The decay of hot nuclei

    International Nuclear Information System (INIS)

    Moretto, L.G.; Wozniak, G.J.

    1988-11-01

    The formation of hot compound nuclei in intermediate-energy heavy ion reactions is discussed. The statistical decay of such compound nuclei is responsible for the abundant emission of complex fragments and high energy gamma rays. 43 refs., 23 figs

  8. Isotope shifts in unstable nuclei

    International Nuclear Information System (INIS)

    Rebel, H.

    1980-05-01

    Current experimental investigations of isotope shifts in atomic spectra of unstable nuclei and the resulting information about size and shape of nuclei far off stability are discussed with reference to some representative examples. (orig.)

  9. Energetic Nuclei, Superdensity and Biomedicine

    Science.gov (United States)

    Baldin, A. M.

    1977-01-01

    High-energy, relativistic nuclei were first observed in cosmic rays. Studing these nuclei has provided an opportunity for analyzing the composition of cosmic rays and for experimentally verifying principles governing the behavior of nuclear matter at high and super-high temperatures. Medical research using accelerated nuclei is suggested.…

  10. The hallmarks of fibroblast ageing.

    Science.gov (United States)

    Tigges, Julia; Krutmann, Jean; Fritsche, Ellen; Haendeler, Judith; Schaal, Heiner; Fischer, Jens W; Kalfalah, Faiza; Reinke, Hans; Reifenberger, Guido; Stühler, Kai; Ventura, Natascia; Gundermann, Sabrina; Boukamp, Petra; Boege, Fritz

    2014-06-01

    Ageing is influenced by the intrinsic disposition delineating what is maximally possible and extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic ageing processes act on the dermis, a post-mitotic skin compartment mainly consisting of extracellular matrix and fibroblasts. Dermal fibroblasts are long-lived cells constantly undergoing damage accumulation and (mal-)adaptation, thus constituting a powerful indicator system for human ageing. Here, we use the systematic of ubiquitous hallmarks of ageing (Lopez-Otin et al., 2013, Cell 153) to categorise the available knowledge regarding dermal fibroblast ageing. We discriminate processes inducible in culture from phenomena apparent in skin biopsies or primary cells from old donors, coming to the following conclusions: (i) Fibroblasts aged in culture exhibit most of the established, ubiquitous hallmarks of ageing. (ii) Not all of these hallmarks have been detected or investigated in fibroblasts aged in situ (in the skin). (iii) Dermal fibroblasts aged in vitro and in vivo exhibit additional features currently not considered ubiquitous hallmarks of ageing. (iv) The ageing process of dermal fibroblasts in their physiological tissue environment has only been partially elucidated, although these cells have been a preferred model of cell ageing in vitro for decades. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  11. Disintegration of comet nuclei

    International Nuclear Information System (INIS)

    Ksanfomality, Leonid V

    2012-01-01

    The breaking up of comets into separate pieces, each with its own tail, was seen many times by astronomers of the past. The phenomenon was in sharp contrast to the idea of the eternal and unchangeable celestial firmament and was commonly believed to be an omen of impending disaster, especially for comets with tails stretching across half the sky. It is only now that we have efficient enough space exploration tools to see comet nuclei and even - in the particular case of small comet Hartley-2 in 2010 - to watch their disintegration stage. There are also other suspected candidates for disintegration in the vast family of comet nuclei and other Solar System bodies. (physics of our days)

  12. Pions scatter by nuclei

    International Nuclear Information System (INIS)

    Huefner, J.

    1975-01-01

    Are pions a good tool to study nuclei. If the emphasis of this question rests on ''tool'', the answer must be ''not yet.'' The reason: one does not even understand how a pion interacts with a nucleus. This is part of the many-body problem for strongly interacting particles and its study is a basic problem in physics. One must investigate questions like: Can one understand pion-nucleus interactions from pion-nucleon physics. How does a Δ-resonance look in nuclei. Once one has solved those basic problems, there will be spinoffs in medical, technical and nuclear areas. Then pions can be used as a tool to study nuclear properties

  13. Chaos in collective nuclei

    International Nuclear Information System (INIS)

    Whelan, N.D.

    1993-01-01

    Random Matrix Theory successfully describes the statistics of the low-lying spectra of some nuclei but not of others. It is currently believed that this theory applies to systems in which the corresponding classical motion is chaotic. This conjecture is tested for collective nuclei by studying the Interacting Boson Model. Quantum and classical measures of chaos are proposed and found to be in agreement throughout the parameter space of the model. For some parameter values the measures indicate the presence of a previously unknown approximate symmetry. A phenomenon called partial dynamical symmetry is explored and shown to lead to a suppression of chaos. A time dependent function calculated from the quantum spectrum is discussed. This function is sensitive to the extent of chaos and provides a robust method of analyzing experimental spectra

  14. Chaotic behavior in nuclei

    International Nuclear Information System (INIS)

    Mitchel, G.; Shriner, J.

    2005-01-01

    Although the predictions of Random Matrix Theory (RMT) were available by the early 1960s, data of sufficiently high quality to adequately test the theory were only obtained a decade later by Rainwater. It was another decade later that Bohigas, Haq and Pandey combined the best available nuclear resonance data - the Columbia neutron resonances in heavy nuclei and the TUNL proton resonances in lighter nuclei - to form the Nuclear Data Ensemble. They obtained excellent agreement for the level statistics with the RMT predictions. The expected Porter-Thomas (PT) distribution was considered very early. However, since the widths (amplitudes squared) are measured, the predicted Gaussian distribution for the amplitudes was only qualitatively confirmed. A much more sensitive test was performed by measuring two widths and the relative phase between the two amplitudes. By comparison of the width and amplitude correlations, the Gaussian distribution was confirmed at the 1% level. Following the Bohigas conjecture - that quantum analogs of classically chaotic systems obey RMT - there was an explosion of activity utilizing level statistics in many different quantum systems. In nuclei the focus was verifying the range of applicability of RMT. Of particular interest was the effect of collectivity and of excitation energy on statistical properties. The effect of symmetry breaking on level statistics was examined and early predictions by Dyson were confirmed. The effect of symmetry breaking on the width distribution was also measured for the first time. Although heuristic arguments predicted no change from the PT distribution, experimentally there was a large deviation from the PT prediction. Later theoretical efforts were consistent with this result. The stringent conditions placed on the experiments - for eigenvalue tests the data need to be essentially perfect (few or no missing levels or mis assigned quantum numbers) - has limited the amount of suitable experimental data. The

  15. Structures of exotic nuclei

    International Nuclear Information System (INIS)

    Hamilton, J.H.

    1987-01-01

    Discoveries of many different types of nuclear shape coexistence are being found at both low and high excitation energies throughout the periodic table, as documented in recent reviews. Many new types of shape coexistence have been observed at low excitation energies, for examples bands on more than four different overlapping and coexisting shapes are observed in 185 Au, and competing triaxial and prolate shapes in 71 Se and 176 Pt. Discrete states in super-deformed bands with deformations β 2 ∼ 0.4-0.6, coexisting with other shapes, have been seen to high spin up to 60ℎ in 152 Dy, 132 Ce and 135 Nd. Super-deformed nuclei with N and Z both around 38 and around Z = 38, N ≥ 60. These data led to the discovery of new shell gaps and magic numbers of 38 for N and Z and 60 for N but now for deformed shapes. Marked differences in structure are observed at spins of 6 to 20 in nuclei in this region, which differ by only two protons; for example, 68 Ge and 70 Se. The differences are thought to be related to the competing shell gaps in these nuclei

  16. Elusive active galactic nuclei

    Science.gov (United States)

    Maiolino, R.; Comastri, A.; Gilli, R.; Nagar, N. M.; Bianchi, S.; Böker, T.; Colbert, E.; Krabbe, A.; Marconi, A.; Matt, G.; Salvati, M.

    2003-10-01

    A fraction of active galactic nuclei do not show the classical Seyfert-type signatures in their optical spectra, i.e. they are optically `elusive'. X-ray observations are an optimal tool to identify this class of objects. We combine new Chandra observations with archival X-ray data in order to obtain a first estimate of the fraction of elusive active galactic nuclei (AGN) in local galaxies and to constrain their nature. Our results suggest that elusive AGN have a local density comparable to or even higher than optically classified Seyfert nuclei. Most elusive AGN are heavily absorbed in the X-rays, with gas column densities exceeding 1024 cm-2, suggesting that their peculiar nature is associated with obscuration. It is likely that in elusive AGN the nuclear UV source is completely embedded and the ionizing photons cannot escape, which prevents the formation of a classical narrow-line region. Elusive AGN may contribute significantly to the 30-keV bump of the X-ray background.

  17. Quantification of epithelial cells in coculture with fibroblasts by fluorescence image analysis.

    Science.gov (United States)

    Krtolica, Ana; Ortiz de Solorzano, Carlos; Lockett, Stephen; Campisi, Judith

    2002-10-01

    To demonstrate that senescent fibroblasts stimulate the proliferation and neoplastic transformation of premalignant epithelial cells (Krtolica et al.: Proc Natl Acad Sci USA 98:12072-12077, 2001), we developed methods to quantify the proliferation of epithelial cells cocultured with fibroblasts. We stained epithelial-fibroblast cocultures with the fluorescent DNA-intercalating dye 4,6-diamidino-2-phenylindole (DAPI), or expressed green fluorescent protein (GFP) in the epithelial cells, and then cultured them with fibroblasts. The cocultures were photographed under an inverted microscope with appropriate filters, and the fluorescent images were captured with a digital camera. We modified an image analysis program to selectively recognize the smaller, more intensely fluorescent epithelial cell nuclei in DAPI-stained cultures and used the program to quantify areas with DAPI fluorescence generated by epithelial nuclei or GFP fluorescence generated by epithelial cells in each field. Analysis of the image areas with DAPI and GFP fluorescences produced nearly identical quantification of epithelial cells in coculture with fibroblasts. We confirmed these results by manual counting. In addition, GFP labeling permitted kinetic studies of the same coculture over multiple time points. The image analysis-based quantification method we describe here is an easy and reliable way to monitor cells in coculture and should be useful for a variety of cell biological studies. Copyright 2002 Wiley-Liss, Inc.

  18. Fibroblastic connective tissue nevus: a rare cutaneous lesion analyzed in a series of 25 cases.

    Science.gov (United States)

    de Feraudy, Sébastien; Fletcher, Christopher D M

    2012-10-01

    Fibroblastic connective tissue nevus (FCTN) represents a rare and distinct benign cutaneous mesenchymal lesion of fibroblastic/myofibroblastic lineage, which broadens the spectrum of lesions presently recognized as connective tissue nevus. A series of 25 cases of FCTN has been analyzed to further characterize the clinicopathologic spectrum and immunohistochemical features of this entity. Sixteen patients were female (64%) and 9 were male (36%), with age at presentation ranging from 1.5 months to 58 years (median, 10 y). Most patients presented with a solitary, slowly growing, painless plaque-like or nodular skin lesion. Eleven cases (44%) arose on the trunk, 9 (36%) on the head and neck, and 5 (20%) on the limbs. The lesion was present for a median duration of 11.5 months (mean, 13.2 mo). Grossly, the lesions were tan-brown to tan-white, smooth, and firm. Their size ranged from 0.3 to 2.0 cm in greatest dimension (mean size, 0.67 cm; median, 0.6 cm). All tumors showed poor circumscription and were situated primarily in the reticular deep dermis, extending into the superficial subcutis in 13 cases (52%). The lesion was associated with papillomatous epidermis in 17 cases (70%) and the presence of adipose tissue in the reticular dermis in 14 cases (60.9%). All tumors were composed of a proliferation of bland intradermal fibroblastic/myofibroblastic cells with indistinct palely eosinophilic cytoplasm and tapering nuclei, with no significant cytologic atypia or pleomorphism, arranged in short-intersecting fascicles and entrapping appendages. No mitoses were identified. Immunostains showed positivity for CD34 in 20 of 23 cases (87%) and weak focal positivity for smooth muscle actin in 9 of 19 cases (47%). No case stained positively for desmin or S100 protein. Clinical follow-up was obtained for 14 patients (median duration, 4 y). No tumor recurred locally, even when surgical excision was incomplete. No lesion metastasized. FCTN occurs most commonly as a plaque on the

  19. Nuclei transmutation by collisions with fast hadrons and nuclei

    International Nuclear Information System (INIS)

    Strugalski, Z.; Strugalska-Gola, E.; Drzymala, A.

    1998-01-01

    Atomic nuclei change their mass- and charge-numbers if bombarded by fast hadrons and nuclei; the transmutation appears as a complicated process. It proceeds in a definite way - through a few stages or phases. Adequate identification of the nucleons and light nuclear fragments emitted and evaporated in a hadron-nucleus or nucleus-nucleus collisions and in the collision-induced intranuclear reactions allows one to estimate quantitatively the nuclei transmutations in the various stages (phases) of the process

  20. Anomalous carbon nuclei

    International Nuclear Information System (INIS)

    Gasparian, A.P.

    1984-01-01

    Results are presented from a bubble chamber experiment to search for anomalous mean free path (MFP) phenomena for secondary multicharged fragments (Zsub(f)=5 and 6) of the beam carbon nucleus at 4.2 GeV/c per nucleon. A total of 50000 primary interactions of carbon with propane (C 3 H 8 ) were created. Approximately 6000 beam tragments with charges Zsub(f)=5 and 6 were analyzed in detail to find out an anomalous decrease of MFP. The anomaly is observed only for secondary 12 C nuclei

  1. Particles and nuclei, letters

    International Nuclear Information System (INIS)

    2001-01-01

    The present collection of letters from JINR, Dubna, contains eight separate records on the interaction of high energy Λ 6 He hypernuclear beams with atomic nuclei, the position-sensitive detector of a high spatial resolution on the basis of a multiwire gas electron multiplier, pseudorapidity hadron density at the LHC energy, high precision laser control of the ATLAS tile-calorimeter module mass production at JINR, a new approach to ECG's features recognition involving neural network, subcriticity of a uranium target enriched in 235 U, beam space charge effects in high-current cyclotron injector CI-5, a homogeneous static gravitational field and the principle of equivalence

  2. Active galactic nuclei

    CERN Document Server

    Beckmann, Volker

    2012-01-01

    This AGN textbook includes phenomena based on new results in the X-Ray domain from new telescopes such as Chandra and XMM Newton not mentioned in any other book. Furthermore, it considers also the Fermi Gamma Ray Space Telescope with its revolutionary advances of unprecedented sensitivity, field of view and all-sky monitoring. Those and other new developments as well as simulations of AGN merging events and formations, enabled through latest super-computing capabilities. The book gives an overview on the current knowledge of the Active Galacitc Nuclei phenomenon. The spectral energy d

  3. Elementary excitations in nuclei

    International Nuclear Information System (INIS)

    Lemmer, R.H.

    1987-01-01

    The role of elementary quasi-particle and quasi-hole excitations is reviewed in connection with the analysis of data involving high-lying nuclear states. This article includes discussions on: (i) single quasi-hole excitations in pick-up reactions, (ii) the formation of single quasi-hole and quasi-particle excitations (in different nuclei) during transfer reactions, followed by (iii) quasi-particle quasi-hole excitations in the same nucleus that are produced by photon absorption. Finally, the question of photon absorption in the vicinity of the elementary Δ resonance is discussed, where nucleonic as well as nuclear degrees of freedom can be excited

  4. Particles and nuclei, letters

    International Nuclear Information System (INIS)

    2000-01-01

    The present collection of letters from JINR, Dubna, contains six separate records on the DELPHI experiment at LEP, the Fermi-surface dynamics of rotating nuclei, production of large samples of the silica dioxide aerogel in the 37-litre autoclave and test of its optical properties, preliminary radiation resource results on scintillating fibers, a new algorithm for the direct transformation method of time to digital with the high time resolution and development and design of analogue read-out electronics for HADES drift chamber system

  5. Cumulation of light nuclei

    International Nuclear Information System (INIS)

    Baldin, A.M.; Bondarev, V.K.; Golovanov, L.B.

    1977-01-01

    Limit fragmentation of light nuclei (deuterium, helium) bombarded with 8,6 GeV/c protons was investigated. Fragments (pions, protons and deuterons) were detected within the emission angle 50-150 deg with regard to primary protons and within the pulse range 150-180 MeV/c. By the kinematics of collision of a primary proton with a target at rest the fragments observed correspond to a target mass upto 3 GeV. Thus, the data obtained correspond to teh cumulation upto the third order

  6. Active galactic nuclei

    CERN Document Server

    Blandford, RD; Woltjer, L

    1990-01-01

    Starting with this volume, the Lecture Notes of the renowned Advanced Courses of the Swiss Society for Astrophysics and Astronomy will be published annually. In each course, three extensive lectures given by leading experts in their respective fields cover different and essential aspects of the subject. The 20th course, held at Les Diablerets in April 1990, dealt with current research on active galactic nuclei; it represents the most up-to-date views on the subject, presented with particular regard for clarity. The previous courses considered a wide variety of subjects, beginning with ""Theory

  7. Exotic nuclei and radioactive beams

    International Nuclear Information System (INIS)

    Chomaz, P.

    1996-01-01

    The Nuclei called exotic are all the nuclei that it is necessary to recreate in laboratory to study them. Their life time is too short -in relation to earth age- for it remains enough on earth. The researchers are going to have at their s disposal at GANIL (Caen) with the S.P.I.R.A.L. project, exotic nuclei beams and will study new kinds of nuclear reactions to better understand the atom nucleus. (N.C.). 2 refs., 9 figs

  8. Isolation of Nuclei and Nucleoli.

    Science.gov (United States)

    Pendle, Alison F; Shaw, Peter J

    2017-01-01

    Here we describe methods for producing nuclei from Arabidopsis suspension cultures or root tips of Arabidopsis, wheat, or pea. These methods could be adapted for other species and cell types. The resulting nuclei can be further purified for use in biochemical or proteomic studies, or can be used for microscopy. We also describe how the nuclei can be used to obtain a preparation of nucleoli.

  9. Theory of magic nuclei

    International Nuclear Information System (INIS)

    Nosov, V.G.; Kamchatnov, A.M.

    A consistent theory of the shell and magic oscillations of the masses of spherical nuclei is developed on the basis of the Fermi liquid concept of the energy spectrum of nuclear matter. A ''magic'' relationship between the system's dimensions and the limiting momentum of the quasi-particle distribution is derived; an integer number of the de Broglie half-waves falls on the nuclear diameter. An expression for the discontinuity in the nucleon binding energy in the vicinity of a magic nucleus is obtained. The role of the residual interaction is analyzed. It is shown that the width of the Fermi-surface diffuseness due to the residual interaction is proportional to the squared vector of the quasi-particle orbital angular momentum. The values of the corresponding proportionality factors (the coupling constant for quasi particles) are determined from the experimental data for 52 magic nuclei. The rapid drop of the residual interaction with increasing nuclear size is demonstrated. (7 figures, 3 tables) (U.S.)

  10. Stability of superheavy nuclei

    Science.gov (United States)

    Pomorski, K.; Nerlo-Pomorska, B.; Bartel, J.; Schmitt, C.

    2018-03-01

    The potential-energy surfaces of an extended set of heavy and superheavy even-even nuclei with 92 ≤Z ≤126 and isospins 40 ≤N -Z ≤74 are evaluated within the recently developed Fourier shape parametrization. Ground-state and decay properties are studied for 324 different even-even isotopes in a four-dimensional deformation space, defined by nonaxiality, quadrupole, octupole, and hexadecapole degrees of freedom. Nuclear deformation energies are evaluated in the framework of the macroscopic-microscopic approach, with the Lublin-Strasbourg drop model and a Yukawa-folded mean-field potential. The evolution of the ground-state equilibrium shape (and possible isomeric, metastable states) is studied as a function of Z and N . α -decay Q values and half-lives, as well as fission-barrier heights, are deduced. In order to understand the transition from asymmetric to symmetric fission along the Fm isotopic chain, the properties of all identified fission paths are investigated. Good agreement is found with experimental data wherever available. New interesting features about the population of different fission modes for nuclei beyond Fm are predicted.

  11. Cluster structures in light nuclei

    International Nuclear Information System (INIS)

    Horiuchi, H.

    2000-01-01

    Complete text of publication follows. Clustering in neutron-rich nuclei is discussed. To understand the novel features (1,2,3) of the clustering in neutron-rich nuclei, the basic features of the clustering in stable nuclei (4) are briefly reviewed. In neutron-rich nuclei, the requirement of the stability of clusters is questioned and the threshold rule is no more obeyed. Examples of clustering in Be and B isotopes (4,5) are discussed in some detail. Possible existence of novel type of clustering near neutron dripline is suggested (1). (author)

  12. Fibroblast growth factor receptors in breast cancer.

    Science.gov (United States)

    Wang, Shuwei; Ding, Zhongyang

    2017-05-01

    Fibroblast growth factor receptors are growth factor receptor tyrosine kinases, exerting their roles in embryogenesis, tissue homeostasis, and development of breast cancer. Recent genetic studies have identified some subtypes of fibroblast growth factor receptors as strong genetic loci associated with breast cancer. In this article, we review the recent epidemiological findings and experiment results of fibroblast growth factor receptors in breast cancer. First, we summarized the structure and physiological function of fibroblast growth factor receptors in humans. Then, we discussed the common genetic variations in fibroblast growth factor receptors that affect breast cancer risk. In addition, we also introduced the potential roles of each fibroblast growth factor receptors isoform in breast cancer. Finally, we explored the potential therapeutics targeting fibroblast growth factor receptors for breast cancer. Based on the biological mechanisms of fibroblast growth factor receptors leading to the pathogenesis in breast cancer, targeting fibroblast growth factor receptors may provide new opportunities for breast cancer therapeutic strategies.

  13. Level structures in Yb nuclei far from stable nuclei

    International Nuclear Information System (INIS)

    Hashizume, Akira

    1982-01-01

    Applying n-γ, γ-γ coincidence techniques, the excited levels in 158 Yb and in 157 Yb nuclei were studied. Stress is placed ona neutron detection technique to assign (HI,xn) reactions which produce the nuclei far from β stability line. (author)

  14. Inhibition of fibroblast growth factor receptor with AZD4547 mitigates juvenile nasopharyngeal angiofibroma.

    Science.gov (United States)

    Le, Tran; New, Jacob; Jones, Joel W; Usman, Shireen; Yalamanchali, Sreeya; Tawfik, Ossama; Hoover, Larry; Bruegger, Dan E; Thomas, Sufi Mary

    2017-10-01

    Juvenile nasopharyngeal angiofibroma (JNA) is a benign tumor that presents in adolescent males. Although surgical excision is the mainstay of treatment, recurrences complicate treatment. There is a need to develop less invasive approaches for management. JNA tumors are composed of fibroblasts and vascular endothelial cells. We identified fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor (VEGF) expression in JNA-derived fibroblasts. FGFR influences fibroblast proliferation and VEGF is necessary for angiogenesis. We hypothesized that targeting FGFR would mitigate JNA fibroblast proliferation, invasion, and migration, and that targeting the VEGF receptor would attenuate endothelial tubule formation. After informed consent, fibroblasts from JNA explants of 3 patients were isolated. Fibroblasts were treated with FGFR inhibitor AZD4547, 0 to 25 μg/mL for 72 hours and proliferation was quantified using CyQuant assay. Migration and invasion of JNA were assessed using 24-hour transwell assays with subsequent fixation and quantification. Mitigation of FGFR and downstream signaling was evaluated by immunoblotting. Tubule formation was assessed in human umbilical vein endothelial cells (HUVECs) treated with vehicle control (dimethylsulfoxide [DMSO]) or semaxanib (SU5416) as well as in serum-free media (SFM) or JNA conditioned media (CM). Tubule length was compared between treatment groups. Compared to control, AZD4547 inhibited JNA fibroblast proliferation, migration, and invasion through inhibition of FGFR and downstream signaling, specifically phosphorylation of - p44/42 mitogen activated protein kinase (p44/42 MAPK). JNA fibroblast CM significantly increased HUVEC tubule formation (p = 0.0039). AZD4547 effectively mitigates FGFR signaling and decreases JNA fibroblast proliferation, migration, and invasion. SU5416 attenuated JNA fibroblast-induced tubule formation. AZD4547 may have therapeutic potential in the treatment of JNA. © 2017 ARS

  15. Electron scattering off nuclei

    International Nuclear Information System (INIS)

    Gattone, A.O.

    1989-01-01

    Two recently developed aspects related to the scattering of electrons off nuclei are presented. On the one hand, a model is introduced which emphasizes the relativistic aspects of the problem in the impulse approximation, by demanding strict maintenance of the algebra of the Poincare group. On the other hand, the second model aims at a more sophisticated description of the nuclear response in the case of collective excitations. Basically, it utilizes the RPA formalism with a new development which enables a more careful treatment of the states in the continuum as is the case for the giant resonances. Applications of both models to the description of elastic scattering, inelastic scattering to discrete levels, giant resonances and the quasi-elastic region are discussed. (Author) [es

  16. Antideuteron annihilation on nuclei

    International Nuclear Information System (INIS)

    Cugnon, J.

    1992-01-01

    An investigation of antideuteron annihilation on nuclei within an intranuclear cascade (INC) model is presented. Two models are set up to describe the annihilation itself, which either implies the antideuteron as a whole and occurs at a single point, or which may be considered as two independent nucleon-antinucleon annihilation occurring at different points and different times. Particular attention is paid to the energy transferred from the pions issued from the annihilation to the nuclear system and to the possibility of having a multifragmentation of the target. The latter feature is investigated within a percolation model. The pion distribution and the energy distribution are also discussed. Predictions of proton multiplicity distributions are compared with experiment. (orig.)

  17. Particles and nuclei, letters

    International Nuclear Information System (INIS)

    2002-01-01

    The present collection of letters from JINR, Dubna, contains ten separate records on Wien filter using in exploring on low-energy radioactive nuclei, memory effects in dissipative nucleus-nucleus collision, topological charge and topological susceptibility in connection with translation and gauge invariance, solutions of the multitime Dirac equation, the maximum entropy technique. System's statistical description, the charged conductor inside dielectric. Solution of boundary condition by means of auxiliary charges and the method of linear algebraic equations, optical constants of the TGS single crystal irradiated by power pulsed electron beam, interatomic pair potential and n-e amplitude from slow neutron scattering by noble gases, the two-coordinate multiwire proportional chamber of the high spatial resolution and neutron drip line in the region of O-Mg isotopes

  18. Particles and nuclei, letters

    International Nuclear Information System (INIS)

    2000-01-01

    The present collection of letters from JINR, Dubna, contains seven separate records on the integral representation for structure functions and target mass effects, multiscale properties of DNA primary structure including cross-scale correlations, dissipative evolution of the elementary act, the fine structure of the M T =1 Gamow-Teller resonance in 147g Tb→ 147 Gd β + /EC decay, the behaviour of the TVO temperature sensors in the magnetic fields, a fast method for searching for tracks in multilayer drift chambers of HADES spectrometer, a novel approach to particle track etching including surfactant enhanced control of pore morphology, azimuthal correlations of secondary particles in 32 S induced interactions with Ag(Br) nuclei at 4.5 GeV/ c/ nucleon

  19. Pulsars: gigantic nuclei

    International Nuclear Information System (INIS)

    Xu, Renxin

    2011-01-01

    What is the real nature of pulsars? This is essentially a question of the fundamental strong interaction between quarks at low-energy scale and hence of the non-perturbative quantum chromo-dynamics, the solution of which would certainly be meaningful for us to understand one of the seven millennium prize problems (i.e., "Yang-Mills Theory") named by the Clay Mathematical Institute. After a historical note, it is argued here that a pulsar is very similar to an extremely big nucleus, but is a little bit different from the gigantic nucleus speculated 80 years ago by L. Landau. The paper demonstrates the similarity between pulsars and gigantic nuclei from both points of view: the different manifestations of compact stars and the general behavior of the strong interaction. (author)

  20. Clusters in nuclei

    CERN Document Server

    Following the pioneering discovery of alpha clustering and of molecular resonances, the field of nuclear clustering is today one of those domains of heavy-ion nuclear physics that faces the greatest challenges, yet also contains the greatest opportunities. After many summer schools and workshops, in particular over the last decade, the community of nuclear molecular physicists has decided to collaborate in producing a comprehensive collection of lectures and tutorial reviews covering the field. This third volume follows the successful Lect. Notes Phys. 818 (Vol. 1) and 848 (Vol. 2), and comprises six extensive lectures covering the following topics:  - Gamma Rays and Molecular Structure - Faddeev Equation Approach for Three Cluster Nuclear Reactions - Tomography of the Cluster Structure of Light Nuclei Via Relativistic Dissociation - Clustering Effects Within the Dinuclear Model : From Light to Hyper-heavy Molecules in Dynamical Mean-field Approach - Clusterization in Ternary Fission - Clusters in Light N...

  1. Pion production in nuclei

    International Nuclear Information System (INIS)

    Afnan, I.R.; Thomas, A.W.

    1976-01-01

    A method has been suggested for relating μ-capture in nuclei to pion absorption through partially conserved axial vector current hypothesis. The success of the method relies heavily on the knowledge of the pion absorption amplitude at a momentum transfer equal to the μ-meson mass. That is we need to know the pion absorption amplitude off the mass-shell. The simplest nucleus for which this suggestion can be examined is μ-capture in deuterium. The Koltum-Reitan model is used to determine the pion absorption amplitude off the mass shell. In particular the senstivity of this off-mass-shell extrapolution to details of the N-N interaction is studied. (author)

  2. Collective excitations in nuclei

    International Nuclear Information System (INIS)

    Chomaz, Ph.

    1998-01-01

    The properties of the nucleus cannot be reduced to the properties of its constituents: it is a complex system. The fact that many properties of the nucleus are consequences of the existence of mean-field potential is a manifestation of this complexity. In particular, the nucleons can thus self-organize in collective motions such as giant resonances. Therefore the study of this collective motions is a very good tool to understand the properties of the nucleus itself. The purpose of this article is to stress some aspects of these collective vibrations. We have studied how an ensemble of fermions as the nucleus can self-organize in collective vibrations which are behaving like a gas of bosons in weak interaction. Understanding of these phenomena remains one of the important subjects of actuality in the context of quantal systems in strong interaction. In particular, the study of the states with one or two vibration quanta provides a direct information on the structure of nuclei close to their ground states. Moreover, some collective states appear to be very robust against the onset of chaos. This is the case of the hot giant dipole built on top of a hot nucleus which seems to survive up to rather high temperatures. Their sudden disappearance is still a subject of controversy. It may be that the mean-field and the associated collective states are playing a crucial role also in catastrophic processes such as the phase-transitions. Indeed, when the system is diluted the collective vibrations may become unstable and it seems that these unstable modes provide a natural explanation to the self organization of the system in drops. Finally, considering the diversity of the different structures of exotic nuclei one may expect new vibration types. All these studies are showing the diversity of the collective motions of strongly correlated quantum systems such as the nucleus but many open questions remain to be solved. (authors)

  3. IBA in deformed nuclei

    International Nuclear Information System (INIS)

    Casten, R.F.; Warner, D.D.

    1982-01-01

    The structure and characteristic properties and predictions of the IBA in deformed nuclei are reviewed, and compared with experiment, in particular for 168 Er. Overall, excellent agreement, with a minimum of free parameters (in effect, two, neglecting scale factors on energy differences), was obtained. A particularly surprising, and unavoidable, prediction is that of strong β → γ transitions, a feature characteristically absent in the geometrical model, but manifest empirically. Some discrepancies were also noted, principally for the K=4 excitation, and the detailed magnitudes of some specific B(E2) values. Considerable attention is paid to analyzing the structure of the IBA states and their relation to geometric models. The bandmixing formalism was studied to interpret both the aforementioned discrepancies and the origin of the β → γ transitions. The IBA states, extremely complex in the usual SU(5) basis, are transformed to the SU(3) basis, as is the interaction Hamiltonian. The IBA wave functions appear with much simplified structure in this way as does the structure of the associated B(E2) values. The nature of the symmetry breaking of SU(3) for actual deformed nuclei is seen to be predominantly ΔK=0 mixing. A modified, and more consistent, formalism for the IBA-1 is introduced which is simpler, has fewer free parameters (in effect, one, neglecting scale factors on energy differences), is in at least as good agreement with experiment as the earlier formalism, contains a special case of the 0(6) limit which corresponds to that known empirically, and appears to have a close relationship to the IBA-2. The new formalism facilitates the construction of contour plots of various observables (e.g., energy or B(E2) ratios) as functions of N and chi/sub Q/ which allow the parameter-free discussion of qualitative trajectories or systematics

  4. Collective excitations in nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Chomaz, Ph. [Grand Accelerateur National d`Ions Lourds (GANIL), 14 - Caen (France); Collaboration: La Direction des Sciences de la Matiere du CEA (FR); Le Fonds National de la Recherche Scientifique de Belgique (BE)

    1998-12-31

    The properties of the nucleus cannot be reduced to the properties of its constituents: it is a complex system. The fact that many properties of the nucleus are consequences of the existence of mean-field potential is a manifestation of this complexity. In particular, the nucleons can thus self-organize in collective motions such as giant resonances. Therefore the study of this collective motions is a very good tool to understand the properties of the nucleus itself. The purpose of this article is to stress some aspects of these collective vibrations. We have studied how an ensemble of fermions as the nucleus can self-organize in collective vibrations which are behaving like a gas of bosons in weak interaction. Understanding of these phenomena remains one of the important subjects of actuality in the context of quantal systems in strong interaction. In particular, the study of the states with one or two vibration quanta provides a direct information on the structure of nuclei close to their ground states. Moreover, some collective states appear to be very robust against the onset of chaos. This is the case of the hot giant dipole built on top of a hot nucleus which seems to survive up to rather high temperatures. Their sudden disappearance is still a subject of controversy. It may be that the mean-field and the associated collective states are playing a crucial role also in catastrophic processes such as the phase-transitions. Indeed, when the system is diluted the collective vibrations may become unstable and it seems that these unstable modes provide a natural explanation to the self organization of the system in drops. Finally, considering the diversity of the different structures of exotic nuclei one may expect new vibration types. All these studies are showing the diversity of the collective motions of strongly correlated quantum systems such as the nucleus but many open questions remain to be solved. (authors) 304 refs., 53 figs., 5 tabs.

  5. Spectroscopy of heavy fissionable nuclei

    Indian Academy of Sciences (India)

    2015-08-05

    Aug 5, 2015 ... Nuclei in the actinide chain and beyond are prone to fission owing to ... mass nuclei are typically more difficult, because the intensity is .... j15/2 neutron alignments in a region where shell stablization effects are crucial.

  6. Problem of ''deformed'' superheavy nuclei

    International Nuclear Information System (INIS)

    Sobiczewski, A.; Patyk, Z.; Muntian, I.

    2000-08-01

    Problem of experimental confirmation of deformed shapes of superheavy nuclei situated in the neighbourhood of 270 Hs is discussed. Measurement of the energy E 2+ of the lowest 2+ state in even-even species of these nuclei is considered as a method for this confirmation. The energy is calculated in the cranking approximation for heavy and superheavy nuclei. The branching ratio p 2+ /p 0+ between α decay of a nucleus to this lowest 2+ state and to the ground state 0+ of its daughter is also calculated for these nuclei. The results indicate that a measurement of the energy E 2+ for some superheavy nuclei by electron or α spectroscopy is a promising method for the confirmation of their deformed shapes. (orig.)

  7. Quarks in Few Body Nuclei

    Directory of Open Access Journals (Sweden)

    Holt Roy J.

    2016-01-01

    Full Text Available Electron scattering at very high Bjorken x from hadrons provides an excellent test of models, has an important role in high energy physics, and from nuclei, provides a window into short range correlations. Light nuclei have a key role because of the relatively well-known nuclear structure. The development of a novel tritium target for Jefferson Lab has led to renewed interest in the mass three system. For example, deep inelastic scattering experiments in the light nuclei provide a powerful means to determine the neutron structure function. The isospin dependence of electron scattering from mass-3 nuclei provide information on short range correlations in nuclei. The program using the new tritium target will be presented along with a summary of other experiments aimed at revealing the large-x structure of the nucleon.

  8. Microprobe analysis of human fibroblasts

    International Nuclear Information System (INIS)

    Allan, G.L.; Zhu, J.; Legge, G.J.F.

    1985-01-01

    The Melbourne Proton Microprobe has been used to study the copper content in human skin fibroblast cells derived from patients with the genetic disease Menkes Syndrome. Both normal and diseased cells have been studied to investigate any elemental differences occurring between the two cell types. This paper details the preparatory techniques necessary for individual cell analysis and presents the elemental information with a new three dimensional contour mapping technique. These maps are used to highlight elemental differences between normal and mutant fibroblasts. The work also confirms the expected copper excess found in the Menkes cell and indicates that the microprobe can be used for rapid identification of a Menkes carrier

  9. Case report 511: Fibroblastic rheumatism

    International Nuclear Information System (INIS)

    Hernandez, R.J.; Martel, W.; Headington, J.T.; Kaufman, R.A.; Cincinnati Univ., OH

    1989-01-01

    We report a ten-year-old child with the newly described entity of fibroblastic rheumatism. This child developed rapid, progressive, symmetrical polyarthritis, similar to the radiographic appearance of juvenile rheumatoid arthritis, except for the rapidity of progression. The polyarthritis was preceded by the development of skin nodules with characteristic histological changes. (orig./GDG)

  10. K-bar-mesic nuclei

    International Nuclear Information System (INIS)

    Dote, Akinobu; Akaishi, Yoshinori; Yamazaki, Toshimitsu

    2005-01-01

    New nuclei 'K-bar-Mesic Nuclei' having the strangeness are described. At first it is shown that the strongly attractive nature of K-bar N interaction is reasoned inductively from consideration of the relation between Kaonic hydrogen atom and Λ (1405) which is an excited state of hyperon Λ. The K-bar N interactions are reviewed and summarized into three categories: 1. Phenomenological approach with density dependent K-bar N interaction (DD), relativistic mean field (RMF) approach, and hybrid of them (RMF+DD). 2. Boson exchange model. 3. Chiral SU(3) theory. The investigation of some light K-bar-nuclei by Akaishi and Yamazaki using phenomenological K-bar N interaction is explained in detail. Studies by antisymmetrized molecular dynamics (AMD) approach are also presented. From these theoretical researches, the following feature of K-bar-mesic nuclei are revealed: 1) Ground state is discrete and bound by 100 MeV or more. 2) Density is very high in side the K-bar-mesic nuclei. 3) Strange structures develop which are not seen in ordinary nuclei. Finally some recent experiments to explore K-bar-mesic nuclei are reviewed. (S. Funahashi)

  11. Monopole transitions in hot nuclei

    International Nuclear Information System (INIS)

    Sujkowski, Z.

    1994-01-01

    Monopole transitions can be a signature of shape changing in a hot, pulsating nucleus (the low energy E0 mode) and/or a measure of the compressibility of finite nuclei (GMR, the breathing mode). Experimental information pertaining to GMR is reviewed. Recipes for deducing the incompressibility modules for infinite nuclear matter from data on GMR are discussed. Astrophysical implications are outlined. The first attempts at locating the GMR strength in moderately hot nuclei are described. Prospects for improving the experimental techniques to make an observation of this strength in selected nuclei unambiguous are discussed. (author). 46 refs, 8 figs

  12. Monopole transitions in hot nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Sujkowski, Z. [Soltan Inst. for Nuclear Studies, Otwock-Swierk (Poland)

    1994-12-31

    Monopole transitions can be a signature of shape changing in a hot, pulsating nucleus (the low energy E0 mode) and/or a measure of the compressibility of finite nuclei (GMR, the breathing mode). Experimental information pertaining to GMR is reviewed. Recipes for deducing the incompressibility modules for infinite nuclear matter from data on GMR are discussed. Astrophysical implications are outlined. The first attempts at locating the GMR strength in moderately hot nuclei are described. Prospects for improving the experimental techniques to make an observation of this strength in selected nuclei unambiguous are discussed. (author). 46 refs, 8 figs.

  13. Electron scattering for exotic nuclei

    International Nuclear Information System (INIS)

    Suda, T.

    2013-01-01

    An electron scattering facility is under construction in RIKEN RI Beam Factory, Japan, which is dedicated to the structure studies of short-lived nuclei. This is the world's first and currently only facility of its type. The construction is nearly completed, and the first electron scattering experiment off short-lived nuclei will be carried out in the beginning of next year. The charge density distributions of short-lived nuclei will be precisely determined by elastic electron scattering for the first time. Physics pursued at this facility including future perspectives are explained

  14. Cavitation inception from bubble nuclei

    DEFF Research Database (Denmark)

    Mørch, Knud Aage

    2015-01-01

    , and experimental investigations of bubbles and cavitation inception have been presented. These results suggest that cavitation nuclei in equilibrium are gaseous voids in the water, stabilized by a skin which allows diffusion balance between gas inside the void and gas in solution in the surrounding liquid....... The cavitation nuclei may be free gas bubbles in the bulk of water, or interfacial gaseous voids located on the surface of particles in the water, or on bounding walls. The tensile strength of these nuclei depends not only on the water quality but also on the pressure-time history of the water. A recent model...

  15. Gluon density in nuclei

    International Nuclear Information System (INIS)

    Ayala, A.L.

    1996-01-01

    In this talk we present our detailed study (theory and numbers) on the shadowing corrections to the gluon structure functions for nuclei. Starting from rather controversial information on the nucleon structure function which is originated by the recent HERA data, we develop the Glauber approach for the gluon density in a nucleus based on Mueller formula and estimate the value of the shadowing corrections in this case. Then we calculate the first corrections to the Glauber approach and show that these corrections are big. Based on this practical observation we suggest the new evolution equation which takes into account the shadowing corrections and solve it. We hope to convince you that the new evolution equation gives a good theoretical tool to treat the shadowing corrections for the gluons density in a nucleus and, therefore, it is able to provide the theoretically reliable initial conditions for the time evolution of the nucleus-nucleus cascade. The initial conditions should be fixed both theoretically and phenomenologically before to attack such complicated problems as the mixture of hard and soft processes in nucleus-nucleus interactions at high energy or the theoretically reliable approach to hadron or/and parton cascades for high energy nucleus-nucleus interaction. 35 refs., 24 figs., 1 tab

  16. Supersymmetry in nuclei

    CERN Document Server

    Jolie, J

    2002-01-01

    All the elementary particles that make up matter (as do quarks, electrons, neutrinos....) are fermions, the particles that convey the fundamental interactions (as do photons, gluons, W, Z...) are bosons. Composite particles are either bosons, or fermions according to the number of fermions they contain: if this number is even the particle is a boson, otherwise it is a fermion. According to this rule a proton is a fermion and the He sup 4 atom is a boson. Symmetry plays an important role in the standard model, a symmetry is a transformation that connect bosons with other bosons or fermions with other fermions. Supersymmetry associates a boson with a fermion or a fermion with a boson, in fact supersymmetry connects nuclei that are not generally considered as akin. Supersymmetry has just been observed in low energy levels of Gold sup 1 sup 9 sup 5 sup - sup 1 sup 9 sup 6 and Platinum sup 1 sup 9 sup 4 - sup 1 sup 9 sup 5 , it means that the description of these energy levels is simplified and can be made by a co...

  17. Supersymmetry in nuclei

    International Nuclear Information System (INIS)

    Jolie, J.

    2002-01-01

    All the elementary particles that make up matter (as do quarks, electrons, neutrinos....) are fermions, the particles that convey the fundamental interactions (as do photons, gluons, W, Z...) are bosons. Composite particles are either bosons, or fermions according to the number of fermions they contain: if this number is even the particle is a boson, otherwise it is a fermion. According to this rule a proton is a fermion and the He 4 atom is a boson. Symmetry plays an important role in the standard model, a symmetry is a transformation that connect bosons with other bosons or fermions with other fermions. Supersymmetry associates a boson with a fermion or a fermion with a boson, in fact supersymmetry connects nuclei that are not generally considered as akin. Supersymmetry has just been observed in low energy levels of Gold 195-196 and Platinum 194 - 195 , it means that the description of these energy levels is simplified and can be made by a common set of quantum numbers. (A.C.)

  18. Photon interactions with nuclei

    International Nuclear Information System (INIS)

    Thornton, S.T.; Sealock, R.M.

    1989-01-01

    This document is a progress report for DOE Grant No. FG05-89ER40501, A000. The grant began March, 1989. Our primary research effort has been expended at the LEGS project at Brookhaven National Laboratory. This report will summarize our present research effort at LEGS as well as data analysis and publications from previous experiments performed at SLAC. In addition the principal investigators are heavily involved in the CLAS collaboration in Hall B at CEBAF. We have submitted several letters of intent and proposals and have made commitments to construct experimental equipment for CEBAF. We expect our primary experimental effort to continue at LEGS until CEBAF becomes operational. This report will be divided into separate sections describing our progress at LEGS, SLAC, and CEBAF. We will also discuss our significant efforts in the education and training of both undergraduate and graduate students. Photon detectors are described as well as experiments on delta deformation in nuclei of quasielastic scattering and excitation of the delta by 4 He(e,e')

  19. Parity violation in nuclei

    International Nuclear Information System (INIS)

    Robertson, R.G.H.

    1980-01-01

    A summary of parity violating effects in nuclei is given. Thanks to vigorous experimental and theoretical effort, it now appears that a reasonably well-defined value for the weak isovector π-nucleon coupling constant can be obtained. There is one major uncertainty in the analysis, namely the M2/E1 mixing ratio for the 2.79 MeV transition in 21 Ne. This quantity is virtually impossible to calculate reliably and must be measured. If it turns out to be much larger than 1, then a null result in 21 Ne is expected no matter what the weak interaction, so an experimental determination is urgently needed. The most promising approach is perhaps a measurement of the pair internal conversion coefficient. Of course, a direct measurement of a pure isovector case is highly desirable, and it is to be hoped that the four ΔT = 1 experiments will be pushed still further, and that improved calculations will be made for the 6 Li case. Nuclear parity violation seems to be rapidly approaching an interesting and useful synthesis

  20. Fragmentation of relativistic nuclei

    International Nuclear Information System (INIS)

    Cork, B.

    1975-06-01

    Nuclei with energies of several GeV/n interact with hadrons and produce fragments that encompass the fields of nuclear physics, meson physics, and particle physics. Experimental results are now available to explore problems in nuclear physics such as the validity of the shell model to explain the momentum distribution of fragments, the contribution of giant dipole resonances to fragment production cross sections, the effective Coulomb barrier, and nuclear temperatures. A new approach to meson physics is possible by exploring the nucleon charge-exchange process. Particle physics problems are explored by measuring the energy and target dependence of isotope production cross sections, thus determining if limiting fragmentation and target factorization are valid, and measuring total cross sections to determine if the factorization relation, sigma/sub AB/ 2 = sigma/sub AA/ . sigma/sub BB/, is violated. Also, new experiments have been done to measure the angular distribution of fragments that could be explained as nuclear shock waves, and to explore for ultradense matter produced by very heavy ions incident on heavy atoms. (12 figures, 2 tables)

  1. Symmetries in nuclei

    International Nuclear Information System (INIS)

    Arima, A.

    2003-01-01

    (1) There are symmetries in nature, and the concept of symmetry has been used in art and architecture. The symmetry is evaluated high in the European culture. In China, the symmetry is broken in the paintings but it is valued in the architecture. In Japan, however, the symmetry has been broken everywhere. The serious and interesting question is why these differences happens? (2) In this lecture, I reviewed from the very beginning the importance of the rotational symmetry in quantum mechanics. I am sorry to be too fundamental for specialists of nuclear physics. But for people who do not use these theories, I think that you could understand the mathematical aspects of quantum mechanics and the relation between the angular momentum and the rotational symmetry. (3) To the specialists of nuclear physics, I talked about my idea as follows: dynamical treatment of collective motions in nuclei by IBM, especially the meaning of the degeneracy observed in the rotation bands top of γ vibration and β vibration, and the origin of pseudo-spin symmetry. Namely, if there is a symmetry, a degeneracy occurs. Conversely, if there is a degeneracy, there must be a symmetry. I discussed some details of the observed evidence and this correspondence is my strong belief in physics. (author)

  2. Collective excitations in nuclei

    International Nuclear Information System (INIS)

    Chomaz, Ph.

    1997-01-01

    The properties of the nucleus cannot be reduced to the properties of its constituents: it is a complex system. The fact that many properties of the nucleus are consequences of the existence of mean-field potential is a manifestation of this complexity. In particular the nucleons can thus self-organize in collective motions such as giant resonances. Therefore the study of these collective motions is a very good to understand the properties of the nucleus itself. The purpose of this article was to stress some aspects of these collective vibrations. In particular we have studied how an ensemble of fermions as the nucleus can self-organize in collective vibrations which are behaving like a gas of bosons in weak interaction. The understanding of these phenomena remains one of the important subjects of actually in the context of quantal systems in strong interaction. In particular the study of the states with one or two vibration quanta provides a direct information on the structure if nuclei close to their ground states. (author)

  3. Collective excitations in nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Chomaz, Ph

    1997-12-31

    The properties of the nucleus cannot be reduced to the properties of its constituents: it is a complex system. The fact that many properties of the nucleus are consequences of the existence of mean-field potential is a manifestation of this complexity. In particular the nucleons can thus self-organize in collective motions such as giant resonances. Therefore the study of these collective motions is a very good to understand the properties of the nucleus itself. The purpose of this article was to stress some aspects of these collective vibrations. In particular we have studied how an ensemble of fermions as the nucleus can self-organize in collective vibrations which are behaving like a gas of bosons in weak interaction. The understanding of these phenomena remains one of the important subjects of actually in the context of quantal systems in strong interaction. In particular the study of the states with one or two vibration quanta provides a direct information on the structure if nuclei close to their ground states. (author) 270 refs.

  4. Dynamic polarization of radioactive nuclei

    International Nuclear Information System (INIS)

    Kiselev, Yu.F.; Lyuboshits, V.L.; )

    2001-01-01

    Radioactive nuclei, embedded into a frozen polarized proton target, atr proposed to polarize by means of some dynamic polarization methods. Angular distributions of γ-quanta emitted ny 22 Na(3 + ) in the cascade β-γ-radiation are calculated. It is shown that this distribution does not depend on the spin temperature sing at the Boltzmann distribution of populations among the Zeeman magnetic substates, whereas the tensor polarization of quadrupole nuclei, placed in the electric field of the crystal, causes the considerable sing dependence. The new method promises wide opportunities for the magnetic structure investigations as well as for the study of spin-spin interaction dynamics of rare nuclei in dielectrics. Physical-technical advantages and disadvantages of the given method are discussed for the polarization of heavy nuclei in the on-line implantation mode [ru

  5. The delta in nuclei. Experiments

    International Nuclear Information System (INIS)

    Roy-Stephan, M.

    1989-01-01

    Experimental aspects of the Δ excitation will be presented. The Δ excitation in nuclei will be compared to the free Δ excitation. Various probes will be reviewed and their specific features will be underlined [fr

  6. Electron scattering for exotic nuclei

    Indian Academy of Sciences (India)

    2014-11-04

    Nov 4, 2014 ... Research Center for Electron-Photon Science, Tohoku University, 1-2-1 ... nuclei precisely determined by elastic scattering [1]. .... In order to fulfill these requirements, a window-frame shaped dipole magnet with a gap.

  7. Collisions between complex atomic nuclei

    International Nuclear Information System (INIS)

    Vaagen, J. S.

    1977-08-01

    The use of heavy ion accelerators in the study of nuclear structure and states is reviewed. The reactions discussed are the quasielastic reactions in which small amounts of energy and few particles are exchanged between the colliding nuclei. The development of heavy ion accelerators is also discussed, as well as detection equipment. Exotic phenomena, principally the possible existence of superheavy nuclei, are also treated. (JIW)

  8. Particles and nuclei in PANIC

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1987-07-15

    PANIC is the triennal International Conference on Particles and Nuclei, and judging from the latest PANIC, held in Kyoto from 20-24 April there is no need for panic yet. Faced with two pictures – one of nuclei described in nucleon and meson terms, and another of nucleons containing quarks and gluons – physicists are intrigued to know what new insights from the quark level can tell us about nuclear physics, or vice versa.

  9. Particles and nuclei in PANIC

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    PANIC is the triennal International Conference on Particles and Nuclei, and judging from the latest PANIC, held in Kyoto from 20-24 April there is no need for panic yet. Faced with two pictures – one of nuclei described in nucleon and meson terms, and another of nucleons containing quarks and gluons – physicists are intrigued to know what new insights from the quark level can tell us about nuclear physics, or vice versa

  10. Investigation of copper nuclei

    International Nuclear Information System (INIS)

    Delfini, M.G.

    1983-01-01

    An extensive study has been performed on copper isotopes in the mass region A=63-66. The results of a precise measurement are presented on the properties of levels of 64 Cu and 66 Cu. They were obtained by bombarding the 63 Cu and 65 Cu nuclei with neutrons. The gamma spectra collected after capture of thermal, 2-keV, 24-keV neutrons have been analysed and combined to give a rather extensive set of precise level energies and gamma transition strengths. From the angular distribution of the gamma rays it is possible to obtain information concerning the angular momentum J of several low-lying states. The level schemes derived from such measurements have been used as a test for calculations in the framework of the shell model. The spectral distributions of eigenstates in 64 Cu for different configuration spaces are presented and discussed. In this study the relative importance of configurations with n holes in the 1f7/2 shell with n up to 16, are investigated. It is found that the results strongly depend on the values of the single-particle energies. The results of the spectral-distribution method were utilized for shell-model calculations. From the information obtained from the spectral analysis it was decided to adopt a configuration space which includes up to one hole in the 1f7/2 shell and up to two particles in the 1g9/2 shell. Further, restrictions on seniority and on the coupling of the two particles in the 1g9/2 orbit have been applied and their effects have been studied. It is found that the calculated excitation energies reproduce the measured values in a satisfactory way, but that some of the electromagnetic properties are less well in agreement with experimental data. (Auth.)

  11. Quest for superheavy nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Heenen, P.H. [Universite Libre de Bruxelles, Service de Physique Nucleaire Theorique (Belgium); Nazarewicz, W. [Tennessee Univ., Knoxville, TN (United States). Dept. of Physics; Warsaw Univ. (Poland). Inst. Fizyki Teoretycznej

    2002-02-01

    This article draws the long history of the discovery of new heavy nuclei since its beginning in 1940 when neptunium was found, and presents the current status of research in this field. The last 3 years have brought a number of experimental surprises which have truly rejuvenated the field. In January 1999, scientists from Dubna (Russia) reported the synthesis of 1 atom of element 114 ({sup 298}Uuq) in a hot fusion reaction between a {sup 48}Ca beam and a {sup 244}Pu target. This discovery was followed by 3 other reports from Dubna. First using the {sup 242}Pu({sup 48}Ca,3n) reaction, they produced {sup 287}Uuq. In 1999 the synthesis of another isotope of Z=114, the even-even {sup 288}Uuq was reported. The element Z=116 ({sup 292}Uuh) was discovered as a product of the {sup 248}Cm({sup 48}Ca,4n) reaction. The GSI (Germany) group found a new even isotope of the element 110: {sup 270}Uun and also {sup 272}Uuu (element 111) and {sup 277}Uub (element 112). 2 new isotopes of the element 107: {sup 266}Bh and {sup 267}Bh have been found at Berkeley (Usa). The synthesis of the new element Z=118 ({sup 293}Uuo) announced in 1999 by the Berkeley group was retracted 2 years later. The lifetimes reported for the elements {sup 284}Uub and {sup 280}Uun are by many orders of magnitude longer than those of the isotopes with Z{<=}112 previously discovered at GSI. (A.C.)

  12. Spectrin-like proteins in plant nuclei

    NARCIS (Netherlands)

    Ruijter, de N.C.A.; Ketelaar, T.; Blumenthal, S.S.D.; Emons, A.M.C.; Schel, J.H.N.

    2000-01-01

    We analysed the presence and localization of spectrin-like proteins in nuclei of various plant tissues, using several anti-erythrocyte spectrin antibodies on isolated pea nuclei and nuclei in cells. Western blots of extracted purified pea nuclei show a cross-reactive pair of bands at 220–240 kDa,

  13. Bio-artificial pleura using an autologous dermal fibroblast sheet

    Science.gov (United States)

    Kanzaki, Masato; Takagi, Ryo; Washio, Kaoru; Kokubo, Mami; Yamato, Masayuki

    2017-10-01

    Air leaks (ALs) are observed after pulmonary resections, and without proper treatment, can produce severe complications. AL prevention is a critical objective for managing patients after pulmonary resection. This study applied autologous dermal fibroblast sheets (DFS) to close ALs. For sealing ALs in a 44-year-old male human patient with multiple bullae, a 5 × 15-mm section of skin was surgically excised. From this skin specimen, primary dermal fibroblasts were isolated and cultured for 4 weeks to produce DFSs that were harvested after a 10-day culture. ALs were completely sealed using surgical placement of these autologous DFSs. DFS were found to be a durable long-term AL sealant, exhibiting requisite flexibility, elasticity, durability, biocompatibility, and usability, resulting reliable AL closure. DFS should prove to be an extremely useful tissue-engineered pleura substitute.

  14. Effect of saccharin on metabolic cooperation between human fibroblasts

    International Nuclear Information System (INIS)

    Mosser, D.D.; Bols, N.C.

    1983-01-01

    Autoradiography was used to study the effect of saccharin on metabolic cooperation between human diploid fibroblasts. When the donors, HGPRT+ cells, and recipients, HGPRT- cells, were plated together in the presence of saccharin, all the interactions that developed in 4 and 24 h were positive for metabolic cooperation. When saccharin was added after donor cells and recipient cells had made contact, the proportion of interactions that were positive for metabolic cooperation was unchanged but the number of grains over primary recipients was reduced. However, in donor cells saccharin caused a reduction in [ 3 H]hypoxanthine incorporation into both acid-soluble and acid-insoluble fractions, although the relative distribution of radioactivity between these two fractions and between the phosphorylated and non-phosphorylated derivatives of [ 3 H]hypoxanthine was unchanged. Metabolic cooperation was studied under conditions in which the number of grains over the nuclei of both the primary recipient and the primary recipient's donor could be counted. The change in the number of grains over these two cell types in response to saccharin was compared and found to be the same. Thus in normal human fibroblasts saccharin does not appear to affect metabolic cooperation, which is a measure of cell-to-cell communication

  15. From heavy nuclei to super-heavy nuclei

    International Nuclear Information System (INIS)

    Theisen, Ch.

    2003-01-01

    The existence of super-heavy nuclei has been predicted nearly fifty years ago. Due to the strong coulomb repulsion, the stabilisation of these nuclei is possible only through shell effects. The reasons for this fragile stability, as well as the theoretical predictions concerning the position of the island of stability are presented in the first part of this lecture. In the second part, experiments and experimental techniques which have been used to synthesize or search for super-heavy elements are described. Spectroscopic studies performed in very heavy elements are presented in the following section. We close this lecture with techniques that are currently being developed in order to reach the superheavy island and to study the structure of very-heavy nuclei. (author)

  16. Complete destruction of heavy nuclei by hadrons and nuclei

    International Nuclear Information System (INIS)

    Tolstov, K.D.

    1980-01-01

    The total disintegration is considered of Ag and Pb nuclei and 4 He, 12 C nuclei With a momentum of 4.5 GeV/c per nucleon. It is shown that nucleons are mainly emitted, and there is no residual nUcleus the mass of which is comparable to that of the primary nucleus. The probability of total nucleus disintegration is considered as a function of projectile energy and the mass. The multiplicity, energy and emission angle of particles are considerred as well. It is shown that the density of nuclear matter in the overlap zone of colliding nuclei exceeds the usual one by a factor of approximately 4. A comparison is made with interaction models. A conclusion is drawn of the collective interaction mechanism (perhaps, of the shock wave type) of particle ejection from the target nucleus at the first stage of interaction and of explosive decay of the residual nucleus at the next one

  17. Fibroblast-matrix interplay: Nintedanib and pirfenidone modulate the effect of IPF fibroblast-conditioned matrix on normal fibroblast phenotype.

    Science.gov (United States)

    Epstein Shochet, Gali; Wollin, Lutz; Shitrit, David

    2018-03-12

    Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis. Activated fibroblasts are the key effector cells in fibrosis, producing excessive amounts of collagen and extracellular matrix (ECM) proteins. Whether the ECM conditioned by IPF fibroblasts determines the phenotype of naïve fibroblasts is difficult to explore. IPF-derived primary fibroblasts were cultured on Matrigel and then cleared using ammonium hydroxide, creating an IPF-conditioned matrix (CM). Normal fibroblast CM served as control. Normal fibroblasts were cultured on both types of CM, and cell count, cell distribution and markers of myofibroblast differentiation; transforming growth factor beta (TGFβ) signalling; and ECM expression were assessed. The effects of the anti-fibrotic drugs nintedanib and pirfenidone at physiologically relevant concentrations were also explored. Normal fibroblasts cultured on IPF-CM arranged in large aggregates as a result of increased proliferation and migration. Moreover, increased levels of pSmad3, pSTAT3 (phospho signal transducer and activator of transcription 3), alpha smooth muscle actin (αSMA) and Collagen1a were found, suggesting a differentiation towards a myofibroblast-like phenotype. SB505124 (10 μmol/L) partially reversed these alterations, suggesting a TGFβ contribution. Furthermore, nintedanib at 100 nmol/L and, to a lesser extent, pirfenidone at 100 μmol/L prevented the IPF-CM-induced fibroblast phenotype alterations, suggesting an attenuation of the ECM-fibroblast interplay. IPF fibroblasts alter the ECM, thus creating a CM that further propagates an IPF-like phenotype in normal fibroblasts. This assay demonstrated differences in drug activities for approved IPF drugs at clinically relevant concentrations. Thus, the matrix-fibroblast phenotype interplay might be a relevant assay to explore drug candidates for IPF treatment. © 2018 Asian Pacific Society of Respirology.

  18. Reflection asymmetric shapes in nuclei

    International Nuclear Information System (INIS)

    Ahmad, I.; Carpenter, M.P.; Emling, H.

    1989-01-01

    Experimental data show that there is no even-even nucleus with a reflection asymmetric shape in its ground state. Maximum octupole- octupole correlations occur in nuclei in the mass 224 (N∼134, Z∼88) region. Parity doublets, which are the characteristic signature of octupole deformation, have been observed in several odd mass Ra, Ac and Pa nuclei. Intertwined negative and positive parity levels have been observed in several even-even Ra and Th nuclei above spin ∼8ℎ. In both cases, the opposite parity states are connected by fast El transitions. In some medium-mass nuclei intertwined negative and positive parity levels have also been observed above spin ∼7ℎ. The nuclei which exhibit octupole deformation in this mass region are 144 Ba, 146 Ba and 146 Ce; 142 Ba, 148 Ce, 150 Ce and 142 Xe do not show these characteristics. No case of parity doublet has been observed in the mass 144 region. 32 refs., 16 figs., 1 tab

  19. Protonic decay of oriented nuclei

    International Nuclear Information System (INIS)

    Kadmensky, S.G.

    2002-01-01

    On the basis of the multiparticle theory of protonic decay, the angular distributions of protons emitted by oriented spherical and deformed nuclei in the laboratory frame and in the internal coordinate frame of deformed parent nuclei are constructed with allowance for symmetry with respect to time inversion. It is shown that, because of the deep-subbarrier character of protonic decay, the adiabatic approximation is not applicable to describing the angular distributions of protons emitted by oriented deformed nuclei and that the angular distribution of protons in the laboratory frame does not coincide with that in the internal coordinate frame. It is demonstrated that these angular distributions coincide only if the adiabatic and the semiclassical approximation are simultaneously valid

  20. Nuclei in a neutron star

    International Nuclear Information System (INIS)

    Oyamatsu, K.; Yamada, M.

    1994-01-01

    We report on the recent progress in understanding the matter in the crust of a neutron star. For nuclides in the outer crust, recently measured masses of neutron-rich nuclei enable us to determine more accurately the stable nuclide as a function of the matter density. In the inner crust, the compressible liquid-drop model predicts successive change of the nuclear shape, from sphere to cylinder, slab, cylindrical hole and spherical hole at densities just before the transition to uniform matter. In order to go beyond the liquiddrop model, we performed the Thomas-Fermi calculation paying special attention to the surface diffuseness, and have recently calculated the shell energies of the non-spherical nuclei. We have found from these studies that all these non-spherical nuclei exist stably in the above order even if we include the surface diffuseness and shell energies. (author)

  1. The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts.

    Directory of Open Access Journals (Sweden)

    Lucia Pagani

    Full Text Available BACKGROUND: Diurnal behavior in humans is governed by the period length of a circadian clock in the suprachiasmatic nuclei of the brain hypothalamus. Nevertheless, the cell-intrinsic mechanism of this clock is present in most cells of the body. We have shown previously that for individuals of extreme chronotype ("larks" and "owls", clock properties measured in human fibroblasts correlated with extreme diurnal behavior. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we have measured circadian period in human primary fibroblasts taken from normal individuals and, for the first time, compared it directly with physiological period measured in vivo in the same subjects. Human physiological period length was estimated via the secretion pattern of the hormone melatonin in two different groups of sighted subjects and one group of totally blind subjects, each using different methods. Fibroblast period length was measured via cyclical expression of a lentivirally delivered circadian reporter. Within each group, a positive linear correlation was observed between circadian period length in physiology and in fibroblast gene expression. Interestingly, although blind individuals showed on average the same fibroblast clock properties as sighted ones, their physiological periods were significantly longer. CONCLUSIONS/SIGNIFICANCE: We conclude that the period of human circadian behaviour is mostly driven by cellular clock properties in normal individuals and can be approximated by measurement in peripheral cells such as fibroblasts. Based upon differences among sighted and blind subjects, we also speculate that period can be modified by prolonged unusual conditions such as the total light deprivation of blindness.

  2. Neutron scattering on deformed nuclei

    International Nuclear Information System (INIS)

    Hansen, L.F.; Haight, R.C.; Pohl, B.A.; Wong, C.; Lagrange, C.

    1984-09-01

    Measurements of neutron elastic and inelastic differential cross sections around 14 MeV for 9 Be, C, 181 Ta, 232 Th, 238 U and 239 Pu have been analyzed using a coupled channel (CC) formalism for deformed nuclei and phenomenological global optical model potentials (OMP). For the actinide targets these results are compared with the predictions of a semi-microscopic calculation using Jeukenne, Lejeune and Mahaux (JLM) microscopic OMP and a deformed ground state nuclear density. The overall agreement between calculations and the measurements is reasonable good even for the very light nuclei, where the quality of the fits is better than those obtained with spherical OMP

  3. Nuclei, hadrons, and elementary particles

    International Nuclear Information System (INIS)

    Bopp, F.W.

    1989-01-01

    This book is a short introduction to the physics of the nuclei, hadrons, and elementary particles for students of physics. Important facts and model imaginations on the structure, the decay, and the scattering of nuclei, the 'zoology' of the hadrons and basic facts of hadronic scattering processes, a short introduction to quantum electrodynamics and quantum chromodynamics and the most important processes of lepton and parton physics, as well as the current-current approach of weak interactions and the Glashow-Weinberg-Salam theory are presented. (orig.) With 153 figs., 10 tabs [de

  4. Octupole shapes in heavy nuclei

    International Nuclear Information System (INIS)

    Ahmad, I.

    1994-01-01

    Theoretical calculations and measurements show the presence of strong octupole correlations in thecyround states and low-lying states of odd-mass and odd-odd nuclei in the RaPa region. Evidence for octupole correlations is provided by the observation of parity doublets and reductions in M1 matrix elements, decoupling parameters, and Coriolis matrix elements Involving high-j states. Enhancement of E1 transition rates has also been observed for some of the octupole deformed nuclei. The most convincing argument for octupole deformation is provided by the similarities of the reduced alpha decay rates to the two members of parity doublets

  5. Exotic Nuclei Arena in JHP

    International Nuclear Information System (INIS)

    Nomura, T.

    1991-12-01

    The Exotic Nuclei Arena planned in Japanese Hadron Project aims to accelerate various unstable nuclei produced in 1-GeV proton-induced reactions up to 6.5 MeV/u by means of heavy-ion linacs. The present status of research and development for the Earena is briefly reported. The construction of the prototype facility to accelerate unstable beams up to 0.8 MeV/u is planned in 1992-94, in which the existing cyclotron in INS is used as the primary accelerator. (author)

  6. Spinodal decomposition of atomic nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Chomaz, P. [Grand Accelerateur National d`Ions Lourds (GANIL), 14 - Caen (France); Colonna, M.; Guarnera, A. [Grand Accelerateur National d`Ions Lourds (GANIL), 14 - Caen (France)]|[LNS, Catania (Italy)

    1996-12-31

    Multifragmentation of atomic nuclei is discussed. It is shown that this description of the dynamics of first order phase transitions in infinite and finite system is now partially achieved. An important conclusion is that in some specific cases well-defined collective motions were initiating the self-organisation of the unstable matter in fragments. In the case of finite systems the possible signals kept from this early fragmentation stage can inform on the possible occurrence of a liquid-gas phase transition in nuclei. (K.A.). 21 refs.

  7. Spinodal decomposition of atomic nuclei

    International Nuclear Information System (INIS)

    Chomaz, P.; Colonna, M.; Guarnera, A.

    1996-01-01

    Multifragmentation of atomic nuclei is discussed. It is shown that this description of the dynamics of first order phase transitions in infinite and finite system is now partially achieved. An important conclusion is that in some specific cases well-defined collective motions were initiating the self-organisation of the unstable matter in fragments. In the case of finite systems the possible signals kept from this early fragmentation stage can inform on the possible occurrence of a liquid-gas phase transition in nuclei. (K.A.)

  8. Are there superheavy atomic nuclei

    International Nuclear Information System (INIS)

    Herrmann, G.

    1982-04-01

    The author presents a populary introduction to the formation of nuclei with special regards to superheavy nuclei. After a general description of the methods of physics the atomic hypothesis is considered. Thereafter the structure of the nucleus is discussed, and the different isotopes are considered. Then radioactivity is described as an element transmutation. Thereafter the thermonuclear reactions in the sun are considered. Then the synthesis of elements using heavy ion reactions is described. In this connection the transuranium elements and the superheavy elements are considered. (orig./HSI) [de

  9. The mechanism of total disintegration of heavy nuclei by fast hadrons and nuclei

    International Nuclear Information System (INIS)

    Strugalska-Gola, E.; Strugalski, Z.

    1997-01-01

    The mechanism of the total disintegration of atomic nuclei by fast hadrons and nuclei is considered. The passage of energetic hadrons through layers of intranuclear matter, accompanied by emission of fast nucleons with kinetic energies from about 20 up to about 500 MeV from definite local small regions in the nuclei around projectile courses in them, allows one to explain simply the occurrence of the total destruction of nuclei involved in the collisions. Light nuclei may be totally disintegrated by fast hadrons and nuclei; heavier nuclei may be totally disintegrated only in central collisions of nuclei with similar mass numbers

  10. Fibroblast spheroids as a model to study sustained fibroblast quiescence and their crosstalk with tumor cells

    Energy Technology Data Exchange (ETDEWEB)

    Salmenperä, Pertteli, E-mail: pertteli.salmenpera@helsinki.fi [Department of Virology, Medicum, Faculty of Medicine, University of Helsinki, P.O. Box 21, FIN-00014 (Finland); Karhemo, Piia-Riitta [Research Programs Unit, Translational Cancer Biology, and Institute of Biomedicine, University of Helsinki, P.O. Box 63, FIN-00014 (Finland); Räsänen, Kati [Department of Virology, Medicum, Faculty of Medicine, University of Helsinki, P.O. Box 21, FIN-00014 (Finland); Laakkonen, Pirjo [Research Programs Unit, Translational Cancer Biology, and Institute of Biomedicine, University of Helsinki, P.O. Box 63, FIN-00014 (Finland); Vaheri, Antti [Department of Virology, Medicum, Faculty of Medicine, University of Helsinki, P.O. Box 21, FIN-00014 (Finland)

    2016-07-01

    Stromal fibroblasts have an important role in regulating tumor progression. Normal and quiescent fibroblasts have been shown to restrict and control cancer cell growth, while cancer-associated, i. e. activated fibroblasts have been shown to enhance proliferation and metastasis of cancer cells. In this study we describe generation of quiescent fibroblasts in multicellular spheroids and their effects on squamous cell carcinoma (SCC) growth in soft-agarose and xenograft models. Quiescent phenotype of fibroblasts was determined by global down-regulation of expression of genes related to cell cycle and increased expression of p27. Interestingly, microarray analysis showed that fibroblast quiescence was associated with similar secretory phenotype as seen in senescence and they expressed senescence-associated-β-galactosidase. Quiescent fibroblasts spheroids also restricted the growth of RT3 SCC cells both in soft-agarose and xenograft models unlike proliferating fibroblasts. Restricted tumor growth was associated with marginally increased tumor cell senescence and cellular differentiation, showed with senescence-associated-β-galactosidase and cytokeratin 7 staining. Our results show that the fibroblasts spheroids can be used as a model to study cellular quiescence and their effects on cancer cell progression. - Highlights: • Fibroblasts acquire a sustained quiescence when grown as multicellular spheroids. • This quiescence is associated with drastic change in gene expression. • Fibroblasts spheroids secrete various inflammation-linked cytokines and chemokines. • Fibroblasts spheroids reduced growth of RT3 SCC cells in xenograft model.

  11. Cryopreservation of dermal fibroblasts and keratinocytes in hydroxyethyl starch-based cryoprotectants.

    Science.gov (United States)

    Naaldijk, Yahaira; Johnson, Adiv A; Friedrich-Stöckigt, Annett; Stolzing, Alexandra

    2016-12-01

    Preservation of human skin fibroblasts and keratinocytes is essential for the creation of skin tissue banks. For successful cryopreservation of cells, selection of an appropriate cryoprotectant agent (CPA) is imperative. The aim of this study was to identify CPAs that minimize toxic effects and allow for the preservation of human fibroblasts and keratinocytes in suspension and in monolayers. We cryopreserved human fibroblasts and keratinocytes with different CPAs and compared them to fresh, unfrozen cells. Cells were frozen in the presence and absence of hydroxyethyl starch (HES) or dimethyl sulfoxide (DMSO), the latter of which is a commonly used CPA known to exert toxic effects on cells. Cell numbers were counted immediately post-thaw as well as three days after thawing. Cellular structures were analyzed and counted by labeling nuclei, mitochondria, and actin filaments. We found that successful cryopreservation of suspended or adherent keratinocytes can be accomplished with a 10% HES or a 5% HES, 5% DMSO solution. Cell viability of fibroblasts cryopreserved in suspension was maintained with 10% HES or 5% HES, 5% DMSO solutions. Adherent, cryopreserved fibroblasts were successfully maintained with a 5% HES, 5% DMSO solution. We conclude that skin tissue cells can be effectively cryopreserved by substituting all or a portion of DMSO with HES. Given that DMSO is the most commonly used CPA and is believed to be more toxic than HES, these findings are of clinical significance for tissue-based replacement therapies. Therapies that require the use of keratinocyte and fibroblast cells, such as those aimed at treating skin wounds or skin burns, may be optimized by substituting a portion or all of DMSO with HES during cryopreservation protocols.

  12. Transitional nuclei near shell closures

    Energy Technology Data Exchange (ETDEWEB)

    Mukherjee, G. [Variable Energy Cyclotron Centre, 1/AF Bidhan Nagar, Kolkata 700064 (India); Pai, H. [Variable Energy Cyclotron Centre, 1/AF Bidhan Nagar, Kolkata 700064, India and Present Address: Institut für Kernphysik, Technische Universität Darmstadt, Schlossgartenstrasse 9, 64289 Darmstadt (Germany)

    2014-08-14

    High spin states in Bismuth and Thallium nuclei near the Z = 82 shell closure and Cesium nuclei near the N = 82 shell closure in A = 190 and A = 130 regions, respectively, have been experimentally investigated using heavy-ion fusion evaporation reaction and by detecting the gamma rays using the Indian National Gamma Array (INGA). Interesting shape properties in these transitional nuclei have been observed. The results were compared with the neighboring nuclei in these two regions. The total Routhian surface (TRS) calculations have been performed for a better understanding of the observed properties. In mass region A = 190, a change in shape from spherical to deformed has been observd around neutron number N = 112 for the Bi (Z = 83) isotopes with proton number above the magic gap Z = 82, whereas, the shape of Tl (Z = 81) isotopes with proton number below the magic gap Z = 82 remains stable as a function of neutron number. An important transition from aplanar to planar configuration of angular momentum vectors leading to the occurance of nuclar chirality and magnetic rotation, respectively, has been proposed for the unique parity πh{sub 11/2}⊗νh{sub 11/2} configuration in Cs isotopes in the mass region A ∼ 130 around neutron number N = 79. These results are in commensurate with the TRS calculations.

  13. Cluster structure in Cf nuclei

    International Nuclear Information System (INIS)

    Singh, Shailesh K.; Biswal, S.K.; Bhuyan, M.; Patra, S.K.; Gupta, R.K.

    2014-01-01

    Due to the availability of advance experimental facilities, it is possible to probe the nuclei upto their nucleon level very precisely and analyzed the internal structure which will help us to resolve some mysterious problem of the decay of nuclei. Recently, the relativistic nuclear collision, confirmed the α cluster type structure in the 12 C which is the mile stone for the cluster structure in nuclei. The clustering phenomena in light and intermediate elements in nuclear chart is very interesting. There is a lot of work done by our group in the clustering behaviour of the nuclei. In this paper, the various prospectus of clustering in the isotopes of Cf nucleus including fission state is discussed. Here, 242 Cf isotope for the analysis, which is experimentally known is taken. The relativistic mean field model with well established NL3 parameter set is taken. For getting the exact ground state configuration of the isotopes, the calculation for minimizing the potential energy surface is performed by constraint method. The clustering structure of other Cf isotopes is discussed

  14. Nuclear astrophysics of light nuclei

    DEFF Research Database (Denmark)

    Fynbo, Hans Otto Uldall

    2013-01-01

    A review of nuclear astrophysics of light nuclei using radioactive beams or techniques developed for radioactive beams is given. We discuss Big Bang nucleosynthesis, with special focus on the lithium problem, aspects of neutrino-physics, helium-burning and finally selected examples of studies...

  15. Particle detection from oriented nuclei

    International Nuclear Information System (INIS)

    Wouters, J.; Moor, P. de; Schuurmans, P.; Severijns, N.; Vanderpoorten, W.; Vanneste, L.

    1992-01-01

    A survey is given of particle emission from nuclei that have been spin oriented by cryogenical means. Experiments and recent developments with detectors in the low temperature environment and their on-line application are reviewed. The most recent results are mentioned. Some phenomena to be unraveled in future studies are pointed out. (orig.)

  16. Rotational damping motion in nuclei

    International Nuclear Information System (INIS)

    Egido, J.L.; Faessler, A.

    1991-01-01

    The recently proposed model to explain the mechanism of the rotational motion damping in nuclei is exactly solved. When compared with the earlier approximative solution, we find significative differences in the low excitation energy limit (i.e. Γ μ 0 ). For the strength functions we find distributions going from the Wigner semicircle through gaussians to Breit-Wigner shapes. (orig.)

  17. Percolation and multifragmentation of nuclei

    International Nuclear Information System (INIS)

    Shmakov, S.Yu.; Uzhinskij, V.V.

    1989-01-01

    A method to build the 'cold' nuclei as percolation clusters is suggested. Within the framework of definite assumptions of the character of nucleon-nucleon couplings breaking resulting from the nuclear reactions as description of the multifragmentation process in the hadron-nucleus and nucleus-nucleus reactions at high energies is obtained. 19 refs.; 6 figs

  18. Octupole correlation effects in nuclei

    International Nuclear Information System (INIS)

    Chasman, R.R.

    1992-01-01

    Octupole correlation effects in nuclei are discussed from the point of view of many-body wavefunctions as well as mean-field methods. The light actinides, where octupole effects are largest, are considered in detail. Comparisons of theory and experiment are made for energy splittings of parity doublets; E1 transition matrix elements and one-nucleon transfer reactions

  19. Electron scattering for exotic nuclei

    Indian Academy of Sciences (India)

    2014-11-04

    Nov 4, 2014 ... A brand-new electron scattering facility, the SCRIT Electron Scattering Facility, will soon start its operation at RIKEN RI Beam Factory, Japan. This is the world's first electron scattering facility dedicated to the structure studies of short-lived nuclei. The goal of this facility is to determine the charge density ...

  20. Radiosensitivity in cultured human fibroblasts

    International Nuclear Information System (INIS)

    Cox, R.; Masson, W.K.

    1980-01-01

    Caution is urged in the use of freshly isolated cultures of human diploid fibroblasts for quantitative studies of radiosensitivity. The distribution of x ray sensitivities of 'normal' human fibroblast cultures of foetal origin (10 subjects, skin or lung biopsy) and post-foetal origin (34 subjects, skin biopsy) are compared with the distribution in 12 patients with ataxia telangiectasia (probability of including any one of these in a normal post-foetal distribution is 0.01%). Cultures from nominally normal subjects showed a broad distribution of D 0 range of 98 +- 160 rad and assuming normal distribution, a mean +- one standard deviation of 122 +- 17 rad. Mean D 0 values for foetal origin cultures were 117 +- 12; values for post-foetal cultures D 0 were 124 +- 18. No systematic variation in D 0 was observed for age of donor, number of cell divisions in culture or for cloning efficiency. For ataxia telangiectasia D 0 values were 46 +- 7 rad. (U.K.)

  1. Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts

    Directory of Open Access Journals (Sweden)

    Chung-Hsun Chang

    2014-11-01

    Full Text Available BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies. However, the underlying mechanism has not been fully clarified. The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawley rat. From the result of cDNA microarray analysis, growth hormone receptor was revealed as one of the most abundantly up-regulated genes in tendon fibroblasts by BPC 157. BPC 157 dose- and time-dependently increased the expression of growth hormone receptor in tendon fibroblasts at both the mRNA and protein levels as measured by RT/real-time PCR and Western blot, respectively. The addition of growth hormone to BPC 157-treated tendon fibroblasts dose- and time-dependently increased the cell proliferation as determined by MTT assay and PCNA expression by RT/real-time PCR. Janus kinase 2, the downstream signal pathway of growth hormone receptor, was activated time-dependently by stimulating the BPC 157-treated tendon fibroblasts with growth hormone. In conclusion, the BPC 157-induced increase of growth hormone receptor in tendon fibroblasts may potentiate the proliferation-promoting effect of growth hormone and contribute to the healing of tendon.

  2. Age of heart disease presentation and dysmorphic nuclei in patients with LMNA mutations.

    Science.gov (United States)

    Core, Jason Q; Mehrabi, Mehrsa; Robinson, Zachery R; Ochs, Alexander R; McCarthy, Linda A; Zaragoza, Michael V; Grosberg, Anna

    2017-01-01

    Nuclear shape defects are a distinguishing characteristic in laminopathies, cancers, and other pathologies. Correlating these defects to the symptoms, mechanisms, and progression of disease requires unbiased, quantitative, and high-throughput means of quantifying nuclear morphology. To accomplish this, we developed a method of automatically segmenting fluorescently stained nuclei in 2D microscopy images and then classifying them as normal or dysmorphic based on three geometric features of the nucleus using a package of Matlab codes. As a test case, cultured skin-fibroblast nuclei of individuals possessing LMNA splice-site mutation (c.357-2A>G), LMNA nonsense mutation (c.736 C>T, pQ246X) in exon 4, LMNA missense mutation (c.1003C>T, pR335W) in exon 6, Hutchinson-Gilford Progeria Syndrome, and no LMNA mutations were analyzed. For each cell type, the percentage of dysmorphic nuclei, and other morphological features such as average nuclear area and average eccentricity were obtained. Compared to blind observers, our procedure implemented in Matlab codes possessed similar accuracy to manual counting of dysmorphic nuclei while being significantly more consistent. The automatic quantification of nuclear defects revealed a correlation between in vitro results and age of patients for initial symptom onset. Our results demonstrate the method's utility in experimental studies of diseases affecting nuclear shape through automated, unbiased, and accurate identification of dysmorphic nuclei.

  3. A repetitive probe for FISH analysis of bovine interphase nuclei

    Directory of Open Access Journals (Sweden)

    Cribiu Edmond

    2000-03-01

    Full Text Available Abstract The purpose of this study was to generate repetitive DNA sequence probes for the analysis of interphase nuclei by fluorescent in situ hybridisation (FISH. Such probes are useful for the diagnosis of chromosomal abnormalities in bovine preimplanted embryos. Of the seven probes (E1A, E4A, Ba, H1A, W18, W22, W5 that were generated and partially sequenced, five corresponded to previously described Bos taurus repetitive DNA (E1A, E4A, Ba, W18, W5, one probe (W22 shared no homology with other DNA sequences and one (H1A displayed a significant homology with Rattus norvegicus mRNA for secretin receptor transmembrane domain 3. Fluorescent in situ hybridisation was performed on metaphase bovine fibroblast cells and showed that five of the seven probes hybridised most centromeres (E1A, E4A, Ba, W18, W22, one labelled the arms of all chromosomes (W5 and the H1A probe was specific to three chromosomes (ch14, ch20, and ch25. Moreover, FISH with H1A resulted in interpretable signals on interphase nuclei in 88% of the cases, while the other probes yielded only dispersed overlapping signals.

  4. Cavitation nuclei measurements - A review

    International Nuclear Information System (INIS)

    Billet, M.L.

    1985-01-01

    The measurement of cavitation nuclei has been the goal of many cavitation research laboratories and has resulted in the development of many methods. Two significantly different approaches have been developed. One is to measure the particulate-microbubble distribution by utilizing acoustical, electrical or optical methods. The other approach measures a liquid tension and a rate of cavitation events for a liquid in order to establish a cavitation susceptibility. Comparisons between various methods indicate that most methods are capable of giving an indication of the nuclei distribution. Measurements obtained in the ocean environment indicate an average of three bubbles per cubic centimeter are present; whereas, water tunnel bubble distributions vary from much less than one to over a hundred per cubic centimeter

  5. Phonon operators in deformed nuclei

    International Nuclear Information System (INIS)

    Soloviev, V.G.

    1981-01-01

    For the description of the excited states in deformed nuclei new phonon operators are introduced, which depend on the sign of the angular momentum projection onto the symmetry axis of a deformed nucleus. In the calculations with new phonons the Pauli principle is correctly taken into account in the two-phonon components of the wave functions. There is a difference in comparison with the calculation with phonons independent of the sign of the angular momentum projection. The new phonons should be used in deformed nuclei if the Pauli principle is consistently taken into account and in the calculations with the excited state wave functions having the components with more than one phonon operator [ru

  6. Phonon operators for deformed nuclei

    International Nuclear Information System (INIS)

    Solov'ev, V.G.

    1982-01-01

    The mathematical formalism with the phonon operators independent of the signature of the angular momentum projection turns out to be inadequate for describing excited states of deformed nuclei. New phonon operators are introduced which depend on the signature of the angular momentum projection on the symmetry axis of a deformed nucleus. It is shown that the calculations with the new phonons take correctly into account the Pauli principle in two-phonon components of wave functions. The results obtained differ from those given by the phonons independent of the signature of the angular momentum projection. The new phonons must be used in deformed nuclei at taking systematically the Pauli principle into account and in calculations involving wave functions of excited states having components with more than one-phonon operator

  7. Nuclear treasure island [superheavy nuclei

    CERN Document Server

    CERN. Geneva

    1999-01-01

    Summary form only given. Soon after the experiments at Dubna, which synthesized element 114 and made the first footprints on the beach of the "island of nuclear stability", two new superheavy elements have been discovered at the Lawrence Berkeley National Laboratory. Element 118 and its immediate decay product, element 116, were manufactured at Berkeley's 88 inch cyclotron by fusing targets of lead-208 with an intense beam of 449 MeV krypton-86 ions. Although both new nuclei almost instantly decay into lighter ones, the decay sequence is consistent with theories that have long predicted the island of stability for nuclei with approximately 114 protons and 184 neutrons. Theorist Robert Smolanczuk, visiting from the Soltan Institute for Nuclear Studies in Poland, had calculated that this reaction should have particularly favourable production rates. Now that this route has been signposted, similar reactions could be possible: new elements and isotopes, tests of nuclear stability and mass models, and a new under...

  8. Moessbauer effects on oriented nuclei

    International Nuclear Information System (INIS)

    Sayouti, E.H.

    1984-01-01

    Standard nuclear orientation methods (not sensitive to the polarization) do not give information on the sign of the magnetic moment. Mossbauer effect separates right-hand and left-hand circularly polarized components, thus its detection on oriented nuclei (T approximately 10 mK) gives the sign of the magnetic moment of oriented state. In this thesis we applied this method to study the 3/2 - ground states of 191 Pt and 193 Os, which are in the prolate-oblate transition region, where assignement of experimental levels to theoretical states is often umbiguous. We show that for those nuclei the sign of the magnetic moment is the signature of the configuration, and its determination establishes the correspondance between experimental and theoretical levels [fr

  9. Clusters in nuclei. Vol. 1

    International Nuclear Information System (INIS)

    Beck, Christian

    2010-01-01

    Following the pioneering discovery of alpha clustering and of molecular resonances, the field of nuclear clustering is presently one of the domains of heavy-ion nuclear physics facing both the greatest challenges and opportunities. After many summer schools and workshops, in particular over the last decade, the community of nuclear molecular physics decided to team up in producing a comprehensive collection of lectures and tutorial reviews covering the field. This first volume, gathering seven extensive lectures, covers the follow topics: - Cluster Radioactivity - Cluster States and Mean Field Theories - Alpha Clustering and Alpha Condensates - Clustering in Neutron-rich Nuclei - Di-neutron Clustering - Collective Clusterization in Nuclei - Giant Nuclear Molecules By promoting new ideas and developments while retaining a pedagogical nature of presentation throughout, these lectures will both serve as a reference and as advanced teaching material for future courses and schools in the fields of nuclear physics and nuclear astrophysics. (orig.)

  10. Mesons and quarks in nuclei

    International Nuclear Information System (INIS)

    Oset, E.

    1980-01-01

    A short review of the topic of mesons in nuclei is exposed paying particular attention to the relationship between several mesonic processes. Special emphasis is put into the microscopic pictures that can ultimately relate all these processes with the elementary coupling of mesons to the nuclear hadronic components. The importance of the short range part of the nuclear interaction opens the doors to a more basic understanding in terms of the quark components of nucleons and isobars. (orig.)

  11. Exclusive photoreactions on light nuclei

    International Nuclear Information System (INIS)

    Maruyama, K.

    1989-08-01

    The mechanism of photon absorption on light nuclei in the Δ-resonance region is discussed. The present status of experimental results is briefly summarized. A recent data from 1.3-GeV Tokyo ES using a π sr spectrometer is introduced. Exclusive measurements of the photodisintegration of 3 He and 4 He may be a clear way to identify 2N, 3N and 4N absorptions. (author)

  12. Fission barriers of light nuclei

    International Nuclear Information System (INIS)

    Grotowski, K.; Planeta, R.; Blann, M.; Komoto, T.

    1989-01-01

    Experimental fission excitation functions for compound nuclei /sup 52/Fe, /sup 49/Cr, /sup 46/V, and /sup 44/Ti formed in heavy-ion reactions are analyzed in the Hauser-Feshbach/Bohr-Wheeler formalism using fission barriers based on the rotating liquid drop model of Cohen et al. and on the rotating finite range model of Sierk. We conclude that the rotating finite range approach gives better reproduction of experimental fission yields, consistent with results found for heavier systems

  13. Impact of matrix stiffness on fibroblast function

    Energy Technology Data Exchange (ETDEWEB)

    El-Mohri, Hichem; Wu, Yang; Mohanty, Swetaparna; Ghosh, Gargi, E-mail: gargi@umich.edu

    2017-05-01

    Chronic non-healing wounds, caused by impaired production of growth factors and reduced vascularization, represent a significant burden to patients, health care professionals, and health care system. While several wound dressing biomaterials have been developed, the impact of the mechanical properties of the dressings on the residing cells and consequently on the healing of the wounds is largely overlooked. The primary focus of this study is to explore whether manipulation of the substrate mechanics can regulate the function of fibroblasts, particularly in the context of their angiogenic activity. A photocrosslinkable hydrogel platform with orthogonal control over gel modulus and cell adhesive sites was developed to explore the quantitative relationship between ECM compliance and fibroblast function. Increase in matrix stiffness resulted in enhanced fibroblast proliferation and stress fiber formation. However, the angiogenic activity of fibroblasts was found to be optimum when the cells were seeded on compliant matrices. Thus, the observations suggest that the stiffness of the wound dressing material may play an important role in the progression of wound healing. - Highlights: • Proliferation and stress fiber formation of fibroblasts increase with increasing matrix mechanics. • Cell area correlates with the growth of fibroblasts. • Angiogenic activity of fibroblasts optimum when cells seeded on compliant gels.

  14. The creation of new nuclei

    International Nuclear Information System (INIS)

    Armbruster, P.; Hessberger, F.P.

    1998-01-01

    In the last 60 years physicists have created 20 artificial elements beyond uranium. In 1934 Enrico Fermi predicted the creation of new elements by bombarding atoms with neutrons. This method led to the discovery of neptunium (Z=93), plutonium, americium, curium, berkelium, californium, einsteinium and fermium (Z=100). In fact the capture of a neutron is followed by a beta-decay which increases the atomic number (Z) by one unit. Beyond Z=100 beta-decay no more occurs so a new approach was necessary. Between the American Lawrence Berkeley Laboratory and the Russian Dubna Institute a fierce competition broke out to produce new elements by bombarding transuranium nuclei with light elements such as helium, carbon, nitrogen. This new method required heavy equipment: ion accelerator and detectors but led to the creation of all the elements from Z=101 to Z=106. A new idea was to provoke the fusion of heavy nuclei such as lead and bismuth with colliding argon, nickel or zinc ion beams. This method called 'cold fusion' opened the way to reach the nuclei beyond Z=107. In 1996 the element Z=112 was the last discovered. The next step could be the element Z=114 for which a particular stability is expected. (A.C.)

  15. Radii of nuclei off stability

    International Nuclear Information System (INIS)

    Sugimoto, Kenzo

    1982-01-01

    An experiment is proposed to determine systematically the radii of the nuclei produced through the projectile fragmentation process in high energy heavy-ion collision. The measurement of total reaction cross section using the projectile fragments of a single nuclide on a target give information about nuclear radii. The production cross section of the fragments is appreciable for many nuclides. Therefore, it is possible to map systematically the reaction radii of the nuclei which can be produced as the projectile fragments. In an experiment using the projectile fragments as the incident beam, the cross section can be expressed as a function of the radii of a projectile and a target. An experiment with He-8 produced by the fragmentation of C-12 is proposed. The He-8 has four neutrons in the p-3/2 orbit outside the He-4 core. Proton and neutron distributions for He isotopes were calculated on the basis of the Hartree-Fock method. The information related to this kind of distribution can be obtained by the proposed experiment. The nuclear structure effect is seen in the nuclear radii of other unstable nuclei. The experimental examples of the isotope shift measurement and the excitation energy are presented. (Kato, T.)

  16. Density functional theory of nuclei

    International Nuclear Information System (INIS)

    Terasaki, Jun

    2008-01-01

    The density functional theory of nuclei has come to draw attention of scientists in the field of nuclear structure because the theory is expected to provide reliable numerical data in wide range on the nuclear chart. This article is organized to present an overview of the theory to the people engaged in the theory of other fields as well as those people in the nuclear physics experiments. At first, the outline of the density functional theory widely used in the electronic systems (condensed matter, atoms, and molecules) was described starting from the Kohn-Sham equation derived on the variational principle. Then the theory used in the field of nuclear physics was presented. Hartree-Fock and Hartree-Fock-Bogolyubov approximation by using Skyrme interaction was explained. Comparison of the results of calculations and experiments of binding energies and ground state mean square charge radii of some magic number nuclei were shown. The similarity and dissimilarity between the two streams were summarized. Finally the activities of the international project of Universal Nuclear Energy Density Functional (UNEDF) which was started recently lead by US scientist was reported. This project is programmed for five years. One of the applications of the project is the calculation of the neutron capture cross section of nuclei on the r-process, which is absolutely necessary for the nucleosynthesis research. (S. Funahashi)

  17. Thermodynamical description of excited nuclei

    International Nuclear Information System (INIS)

    Bonche, P.

    1989-01-01

    In heavy ion collisions it has been possible to obtain composite systems at rather high excitation energies corresponding to temperatures of several MeV. The theoretical studies of these systems are based on concepts borrowed from thermodynamics or statistical physics, such as the temperature. In these lectures, we present the concepts of statistical physics which are involved in the physics of heavy ion as they are produced nowadays in the laboratory and also during the final stage of a supernova collapse. We do not attempt to describe the reaction mechanisms which yield such nuclear systems nor their decay by evaporation or fragmentation. We shall only study their static properties. The content of these lectures is organized in four main sections. The first one gives the basic features of statistical physics and thermodynamics necessary to understand quantum mechanics at finite temperature. In the second one, we present a study of the liquid-gas phase transition in nuclear physics. A phenomenological approach of the stability of hot nuclei follows. The microscopic point of view is proposed in the third part. Starting from the basic concepts derived in the first part, it provides a description of excited or hot nuclei which confirms the qualitative results of the second part. Furthermore it gives a full description of most properties of these nuclei as a function of temperature. Finally in the last part, a microscopic derivation of the equation of state of nuclear matter is proposed to study the collapse of a supernova core

  18. Exotic Nuclei and Yukawa's Forces

    International Nuclear Information System (INIS)

    Otsuka, Takaharu; Suzuki, Toshio; Utsuno, Yutaka

    2008-01-01

    In this plenary talk, we will overview the evolution of the shell structure in stable and exotic nuclei as a new paradigm of nuclear structure physics. This shell evolution is primarily due to the tensor force. The robust mechanism and some examples will be presented. Such examples include the disappearance of existing magic numbers and the appearance of new ones. The nuclear magic numbers have been believed, since Mayer and Jensen, to be constants as 2, 8, 20, 28, 50, ... This turned out to be changed, once we entered the regime of exotic nuclei. This shell evolution develops at many places on the nuclear chart in various forms. For example, superheavy magic numbers may be altered. Thus, we are led to a new paradigm as to how and where the nuclear shell evolves, and what consequences arise. The evolution of the shell affects weak process transitions, and plays a crucial role in deformation. The π and ρ mesons generate tensor forces, and are the fundamental elements of such intriguing phenomena. Thus, physics of exotic nuclei arises as a manifestation of Yukawa's forces

  19. The colours of Hubble Sc galaxy nuclei

    International Nuclear Information System (INIS)

    Iskudaryan, S.G.

    1975-01-01

    The colorimetric data on the nuclei of the Sc galaxies are given. Comparison of the following parameters: color of a nucleus, integral color of a galaxy, Byurakan class, and spectral type of normal spirals gives the possibility to conclude: (1) The colors of the nuclei of the Sc galaxies have a high dispersion in its values. In all Byurakan classes the galaxies with intensely red and blue nuclei occur; (2) Some Sc galaxies exhibit a discrepancy between the spectral and morphological types. The results of colorimetry of nuclei indicate that almost all such Sc galaxies have intensely red nuclei which, naturally, provide for these late spectral types. It can be assumed that the intensely red color of the nuclei of such Sc galaxies is a result of a new type of activity of these nuclei; and (3) some Sc galaxies show the characteristics of the Markarian objects

  20. Pathology of experimental Ebola virus infection in African green monkeys. Involvement of fibroblastic reticular cells.

    Science.gov (United States)

    Davis, K J; Anderson, A O; Geisbert, T W; Steele, K E; Geisbert, J B; Vogel, P; Connolly, B M; Huggins, J W; Jahrling, P B; Jaax, N K

    1997-08-01

    Ebola virus has been responsible for explosive lethal outbreaks of hemorrhagic fever in both humans and nonhuman primates. Previous studies showed a predilection of Ebola virus for cells of the mononuclear phagocyte system and endothelial cells. To examine the distribution of lesions and Ebola virus antigen in the tissues of six adult male African green monkeys (Cercopithecus aethiops) that died 6 to 7 days after intraperitoneal inoculation of Ebola-Zaire (Mayinga) virus. Tissues were examined histologically, immunohistochemically, and ultrastructurally. A major novel finding of this study was that fibroblastic reticular cells were immunohistochemically and ultrastructurally identified as targets of Ebola virus infection. The role of Ebola virus-infected fibroblastic reticular cells in the pathogenesis of Ebola hemorrhagic fever warrants further investigation. This is especially important because of recent observations indicating that fibroblastic reticular cells, along with the reticular fibers they produce, maximize the efficiency of the immune response.

  1. Fibroblast cultures in duchenne muscular dystrophy

    International Nuclear Information System (INIS)

    Ionasescu, V.; Lara-Braud, C.; Zellweger, H.; Ionasescu, R.; Burmeister, L.

    1977-01-01

    Primary skin fibroblast cultures were grown from forearm pinch skin biopsies obtained from 24 patients with Duchenne muscular dystrophy (DMD) and ten normal controls matched for sex and age. The first subcultures were grown for 7 days and incubated with L-( 3 H)-proline for 24 hours. Intracellular collagen incoption was significantly decreased (2.2 X) and extracellular collagen incorporation significantly increased (1.8 X) in fibroblast cultures from patients with DMD by both collagenase assay and polyacrylamide gel electrophoresis. The synthesis of noncollagen proteins showed low values from the DMD fibroblast cultures. The alterations in synthesis and secretion of collagen and noncollagen proteins were characteristic only for the log phase of DMD fibroblasts. (author)

  2. Nuclear targeting of IGF-1 receptor in orbital fibroblasts from Graves' disease: apparent role of ADAM17.

    Directory of Open Access Journals (Sweden)

    Neil Hoa

    Full Text Available Insulin-like growth factor-1 receptor (IGF-1R comprises two subunits, including a ligand binding domain on extra- cellular IGF-1Rα and a tyrosine phosphorylation site located on IGF-1Rβ. IGF-1R is over-expressed by orbital fibroblasts in the autoimmune syndrome, Graves' disease (GD. When activated by IGF-1 or GD-derived IgG (GD-IgG, these fibroblasts produce RANTES and IL-16, while those from healthy donors do not. We now report that IGF-1 and GD-IgG provoke IGF-1R accumulation in the cell nucleus of GD fibroblasts where it co-localizes with chromatin. Nuclear IGF-1R is detected with anti-IGF-1Rα-specific mAb and migrates to approximately 110 kDa, consistent with its identity as an IGF-1R fragment. Nuclear IGF-1R migrating as a 200 kDa protein and consistent with an intact receptor was undetectable when probed with either anti-IGF-1Rα or anti-IGF-1Rβ mAbs. Nuclear redistribution of IGF-1R is absent in control orbital fibroblasts. In GD fibroblasts, it can be abolished by an IGF-1R-blocking mAb, 1H7 and by physiological concentrations of glucocorticoids. When cell-surface IGF-1R is cross-linked with (125I IGF-1, (125I-IGF-1/IGF-1R complexes accumulate in the nuclei of GD fibroblasts. This requires active ADAM17, a membrane associated metalloproteinase, and the phosphorylation of IGF-1R. In contrast, virally encoded IGF-1Rα/GFP fusion protein localizes equivalently in nuclei in both control and GD fibroblasts. This result suggests that generation of IGF-1R fragments may limit the accumulation of nuclear IGF-1R. We thus identify a heretofore-unrecognized behavior of IGF-1R that appears limited to GD-derived fibroblasts. Nuclear IGF-1R may play a role in disease pathogenesis.

  3. Exotic light nuclei and nuclei in the lead region

    International Nuclear Information System (INIS)

    Poppelier, N.A.F.M.

    1989-01-01

    Three methods are discussed for modifying, or renormalizing, a truncated nuclear hamiltonian such that the wave functions obtained by diagonalizing this modified or effective hamiltoniandescribe the nucleus as well as possible: deriving the hamiltonian directly from a realistic nucleon-nucleon interaction between free nucleons; parametrizing the hamiltonian in terms of a number of parameters and determining these parameters from a least-squares fit of calculated properties to experimental data; approximating the nucleon-nucleon (NN) interaction between two nucleons in a nucleus by a simple analytic expression. An effective hamiltonian derived following the second method is applied in a theoretical study of exotic nuclei in the region of Z=2-9 and A=4-30 and the problem of the neutron halo in 11 Li is discussed. Results of shell-model calculations of 20i Pb and nuclei in its neighbourhood are presented in which an effective hamiltonian was employed derived with the last method. The quenching of M1 strength in 208 Pb, and the spectroscopic factors measured in proton knock-out reactions could be described quite satisfactory. Finally, a method is presented for deriving the effective hamiltonian directly from the realistic NN interaction with algebraic techniques. (H.W.). 114 refs.; 34 figs.; 12 tabs.; schemes

  4. Fibroblasts in fibrosis: novel roles and mediators

    Directory of Open Access Journals (Sweden)

    Ryan Thomas Kendall

    2014-05-01

    Full Text Available Fibroblasts are the most common cell type of the connective tissues found throughout the body and the principal source of the extensive extracellular matrix (ECM characteristic of these tissues. They are also the central mediators of the pathological fibrotic accumulation of ECM and the cellular proliferation and differentiation that occurs in response to prolonged tissue injury and chronic inflammation. The transformation of the fibroblast cell lineage involves classical developmental signaling programs and includes a surprisingly diverse range of precursor cell types—most notably, myofibroblasts that are the apex of the fibrotic phenotype. Myofibroblasts display exaggerated ECM production; constitutively secrete and are hypersensitive to chemical signals such as cytokines, chemokines, and growth factors; and are endowed with a contractile apparatus allowing them to manipulate the ECM fibers physically to close open wounds. In addition to ECM production, fibroblasts have multiple concomitant biological roles, such as in wound healing, inflammation, and angiogenesis, which are each interwoven with the process of fibrosis. We now recognize many common fibroblast-related features across various physiological and pathological protracted processes. Indeed, a new appreciation has emerged for the role of noncancerous fibroblast interactions with tumors in cancer progression. Although the predominant current clinical treatments of fibrosis involve nonspecific immunosuppressive and anti-proliferative drugs, a variety of potential therapies under investigation specifically target fibroblast biology.

  5. Isospin mixing in light nuclei

    International Nuclear Information System (INIS)

    Ludwig, E.J.; Clegg, T.B.; Fauber, R.E.; Karwowski, H.J.; Mooney, T.M.; Thompson, W.J.

    1985-01-01

    This program has provided accurate measurements of isospin mixing (ΔT = 1,2) in proton elastic scattering on even-even target nuclei up to A = 40. In order to improve experimental results and to test the hypothesis that isospin mixing is dominated by mixing in the target ground state (as opposed to mixing in the compound system) the authors have undertaken to (1) extend the proton scattering results to additional T = 3/2 states in certain compound systems and (2) examine processes which can proceed by only isotensor mixing (ΔT = 2) in order to isolate the effects of that contribution

  6. Nucleon transfer between heavy nuclei

    International Nuclear Information System (INIS)

    Von Oertzen, W.

    1984-02-01

    Nucleon transfer reactions between heavy nuclei are characterized by the classical behaviour of the scattering orbits. Thus semiclassical concepts are well suited for the description of these reactions. In the present contribution the characteristics of single and multinucleon transfer reactions at energies below and above the Coulomb barrier are shown for systems like Sn+Sn, Xe+U and Ni+Pb. The role of the pairing interaction in the transfer of nucleon pairs is illustrated. For strong transitions the coupling of channels and the absorption into more complicated channels is taken into account in a coupled channels calculation

  7. Microscopic structure for light nuclei

    International Nuclear Information System (INIS)

    Sharma, V.K.

    1995-01-01

    The microscopic structure for light nuclei e.g. 4 He, 7 Li and 8 Be is considered in the frame work of the generator coordinate method (GCM). The physical interpretation of our GCM is also discussed. The GC amplitudes are used to calculate the various properties like charge and magnetic RMS radii, form factors, electromagnetic moments, astrophysical S-factor, Bremsstrahlung weighted cross sections, relative wavefunctions and vertex functions etc. All the calculated quantities agree well with the values determined experimentally. (author). 30 refs., 10 figs., 2 tabs

  8. Microscopic properties of superdeformed nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Karlsson, Lennart B

    1999-04-01

    Many high spin rotational bands in superdeformed nuclei have been found in the A 140 - 150 region, but so far no linking transitions to known normal-deformed states have been found in these nuclei. Therefore, configuration and spin assignments have to be based on indirect spectroscopic information. Identical bands were first discovered in this region of superdeformed states. At present, some identical bands have also been found at normal deformation, but such bands are more common at superdeformation. Recently lifetime measurements have given relative quadrupole moments with high accuracy. Spectroscopic quantities are calculated using the configuration constrained cranked Nilsson-Strutinsky model with the modified oscillator potential. In a statistical study the occurrence of identical bands is tested. Comparing superdeformed and normal deformed nuclei, the higher possibility for identical bands at superdeformation is understood from calculated reduced widths of the E{sub {gamma}} and J{sup (2)} distributions. The importance of high-N orbitals for identical bands is also discussed. Additivity of electric quadrupole moment contributions in the superdeformed A - 150 region is discussed with the nucleus {sup 152}Dy as a `core`. In analytic harmonic oscillator calculations, the effective electric quadrupole moment q{sub eff}, i.e. the change in the total quadrupole moment caused by the added particle, is expressed as a simple function of the single-particle mass, quadrupole moment q{sub {nu}}. Also in realistic calculations, simple relations between q{sub eff} and q{sub {nu}} can be used to estimate the total electric quadrupole moment, e.g. for the nucleus {sup 142}Sm, by adding the effect of 10 holes, to the total electric quadrupole moment of {sup 152}Dy. Furthermore, tools are given for estimating the quadrupole moment for possible configurations in the superdeformed A - 150 region. For the superdeformed region around {sup 143}Eu, configuration and spin assignments

  9. Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells.

    Directory of Open Access Journals (Sweden)

    Jason A Neidleman

    2017-02-01

    Full Text Available Understanding early events of HIV transmission within mucosal tissues is vital for developing effective prevention strategies. Here, we report that primary stromal fibroblasts isolated from endometrium, cervix, foreskin, male urethra, and intestines significantly increase HIV infection of CD4+ T cells-by up to 37-fold for R5-tropic HIV and 100-fold for X4-tropic HIV-without themselves becoming infected. Fibroblasts were more efficient than dendritic cells at trans-infection and mediate this response in the absence of the DC-SIGN and Siglec-1 receptors. In comparison, mucosal epithelial cells secrete antivirals and inhibit HIV infection. These data suggest that breaches in the epithelium allow external or luminal HIV to escape an antiviral environment to access the infection-favorable environment of the stromal fibroblasts, and suggest that resident fibroblasts have a central, but previously unrecognized, role in HIV acquisition at mucosal sites. Inhibiting fibroblast-mediated enhancement of HIV infection should be considered as a novel prevention strategy.

  10. Exotic nuclei: another aspect of nuclear structure

    International Nuclear Information System (INIS)

    Dobaczewski, J.; Blumenfeld, Y.; Flocard, H.; Garcia Borge, M.J.; Nowacki, F.; Rombouts, S.; Theisen, Ch.; Marques, F.M.; Lacroix, D.; Dessagne, P.; Gaeggeler, H.

    2002-01-01

    This document gathers the lectures made at the Joliot Curie international summer school in 2002 whose theme that year was exotic nuclei. There were 11 contributions whose titles are: 1) interactions, symmetry breaking and effective fields from quarks to nuclei; 2) status and perspectives for the study of exotic nuclei: experimental aspects; 3) the pairing interaction and the N = Z nuclei; 4) borders of stability region and exotic decays; 5) shell structure of nuclei: from stability to decay; 6) variational approach of system with a few nucleons; 7) from heavy to super-heavy nuclei; 8) halos, molecules and multi-neutrons; 9) macroscopic approaches for fusion reactions; 10) beta decay: a tool for spectroscopy; 11) the gas phase chemistry of super-heavy elements

  11. On the distribution of quarks in nuclei

    International Nuclear Information System (INIS)

    Baldin, A.M.; Panebrattsev, V.S.; Stavinskij, V.S.

    1984-01-01

    On the basis of the data on cumulative proton, deuteron and nuclear fragment production in hadr on-nucleon reactions and deep inelastic muon-nucleon scattering quark distributions in light, intemediate and heavy nuclei have been investigated. Conditions of limiting fragmentation of hadrons and nuclei in the studied processes have been investigated to obtain quark-parton structure functions (Gs 2 ) of the studied hadrons or nuclei. Invariant differential cross sections of π + , π - , K + meson production on aluminium, deuterium and lead nuclei and their dependence on scale variable at the transverse momentum value Psub(T) approximately 0 have been obtained. Properties of structure functions G 2 and behaviour of different nuclei differential cross sections of limiting fragmentation have been investigated. It is concluded that considered regularities testify to the presence of multiquark states in nuclei, different by its structure from nUcleons

  12. Barriers in the energy of deformed nuclei

    Directory of Open Access Journals (Sweden)

    V. Yu. Denisov

    2014-06-01

    Full Text Available Interaction energy between two nuclei considering to their deformations is studied. Coulomb and nuclear in-teraction energies, as well as the deformation energies of both nuclei, are taken into account at evaluation of the interaction energy. It is shown that the barrier related to the interaction energy of two nuclei depends on the de-formations and the height of the minimal barrier is evaluated. It is obtained that the heavier nucleus-nucleus sys-tems have large deformation values at the lowest barrier. The difference between the barrier between spherical nuclei and the lowest barrier between deformed nuclei increases with the mass and the charge of the interacting nuclei.

  13. Laser method of free atom nuclei orientation

    International Nuclear Information System (INIS)

    Barabanov, A.L.

    1987-01-01

    Orientation process of free atom (atoms in beams) nuclei, scattering quanta of circularly polarized laser radiation is considered. A method for the evaluation of nuclei orientation parameters is developed. It is shown that in the process of pumping between the ground and first excited atomic states with electron shell spins J 1 and J 2 , so that J 2 = J 1 + 1, a complete orientation of nuclei can be attained

  14. Are there multiquark bags in nuclei

    International Nuclear Information System (INIS)

    Kondratyuk, L.A.; Scmatkov, M.Zh.

    1983-01-01

    Arguments are presented favouring the idea that multiquark bags do eXist in nuclei. Such hypothesis makes possible to reveal the relationship among three different scopes of phenomena: deep inelastic scattering of leptons by nUclei, large q 2 (where q 2 is a square of momentum transfer) behaviour of the form factors of light nuclei and yield of cumulative proton.s

  15. Understanding Nuclei in the upper sd - shell

    OpenAIRE

    Sarkar, M. Saha; Bisoi, Abhijit; Ray, Sudatta; Kshetri, Ritesh; Sarkar, S.

    2013-01-01

    Nuclei in the upper-$sd$ shell usually exhibit characteristics of spherical single particle excitations. In the recent years, employment of sophisticated techniques of gamma spectroscopy has led to observation of high spin states of several nuclei near A$\\simeq$ 40. In a few of them multiparticle, multihole rotational states coexist with states of single particle nature. We have studied a few nuclei in this mass region experimentally, using various campaigns of the Indian National Gamma Array...

  16. Possible existence of backbending in actinide nuclei

    International Nuclear Information System (INIS)

    Dudek, J.; Nazarewicz, W.; Szymanski, Z.

    1982-01-01

    The possibilities for the backbending effect to occur in actinide nuclei are studied using the pairing-self-consistent independent quasiparticle method. The Hamiltonian used is that of the deformed Woods-Saxon potential plus monopole pairing term. The results of the calculations explain why there is no backbending in most actinide nuclei and simultaneously suggest that in some light neutron deficient nuclei around Th and 22 Ra a backbending effect may occur

  17. Nuclei quadrupole coupling constants in diatomic molecule

    International Nuclear Information System (INIS)

    Ivanov, A.I.; Rebane, T.K.

    1993-01-01

    An approximate relationship between the constants of quadrupole interaction of nuclei in a two-atom molecule is found. It enabled to establish proportionality of oscillatory-rotation corrections to these constants for both nuclei in the molecule. Similar results were obtained for the factors of electrical dipole-quadrupole screening of nuclei. Applicability of these relationships is proven by the example of lithium deuteride molecule. 4 refs., 1 tab

  18. Nuclei at the limits of particle stability

    International Nuclear Information System (INIS)

    Mueller, A.C.

    1993-01-01

    The properties and synthesis of nuclei at the limits of particle stability are reviewed. Nuclear reactions were induced and studied by means of the 'exotic' nuclear beams, i.e. beams of radioactive drip-line nuclei. The beams are mostly generated in heavy-ion projectile fragmentation. The cases of both neutron-rich and proton-rich nuclei are discussed. (K.A.) 270 refs.; 13 figs.; 1 tab

  19. Selfconsistent calculations for hyperdeformed nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Molique, H.; Dobaczewski, J.; Dudek, J.; Luo, W.D. [Universite Louis Pasteur, Strasbourg (France)

    1996-12-31

    Properties of the hyperdeformed nuclei in the A {approximately} 170 mass range are re-examined using the self-consistent Hartree-Fock method with the SOP parametrization. A comparison with the previous predictions that were based on a non-selfconsistent approach is made. The existence of the {open_quotes}hyper-deformed shell closures{close_quotes} at the proton and neutron numbers Z=70 and N=100 and their very weak dependence on the rotational frequency is suggested; the corresponding single-particle energy gaps are predicted to play a role similar to that of the Z=66 and N=86 gaps in the super-deformed nuclei of the A {approximately} 150 mass range. Selfconsistent calculations suggest also that the A {approximately} 170 hyperdeformed structures have neglegible mass asymmetry in their shapes. Very importantly for the experimental studies, both the fission barriers and the {open_quotes}inner{close_quotes} barriers (that separate the hyperdeformed structures from those with smaller deformations) are predicted to be relatively high, up to the factor of {approximately}2 higher than the corresponding ones in the {sup 152}Dy superdeformed nucleus used as a reference.

  20. Mass-23 nuclei in astrophysics

    International Nuclear Information System (INIS)

    Fraser, P R; Amos, K; Van der Kniff, D; Canton, L; Karataglidis, S; Svenne, J P

    2015-01-01

    The formation of mass-23 nuclei by radiative capture is of great interest in astrophysics. A topical problem associated with these isobars is the so-called 22 Na puzzle of ONe white dwarf novae, where the abundance of 22 Na observed is not as is predicted by current stellar models, indicating there is more to learn about how the distribution of elements in the universe occurred. Another concerns unexplained variations in elements abundance on the surface of aging red giant stars. One method for theoretically studying nuclear scattering is the Multi-Channel Algebraic Scattering (MCAS) formalism. Studies to date have used a simple collective-rotor prescription to model the target states which couple to projectile nucleons. While, in general, the target states considered all belong to the ground state rotor band, for some systems it is necessary to include coupling to states outside of this band. Herein we discuss an extension of MCAS to allow coupling of different strengths between such states and the ground state band. This consideration is essential when studying the scattering of neutrons from 22 Ne, a necessary step in studying the mass-23 nuclei mentioned above. (paper)

  1. Molecular studies of fibroblasts transfected with hepatitis B virus DNA

    International Nuclear Information System (INIS)

    Chen, M.L.; Hood, A.; Thung, S.N.; Gerber, M.A.

    1987-01-01

    Two subclones (D7 and F8) derived from an NIH 3T3 mouse fibroblast cell line after transfection with hepatitis B virus (HBV) genomes, secreted significantly different amounts of HBsAg and HBeAg. DNA extracted from the subclones revealed only integrated and no extrachromosomal HBV DNA sequences as determined by the Southern blot technique with a /sup 32/P-labeled full length HBV DNA probe. The amount and integration sites of HBV sequences were significantly different in the two subclones. HBV DNA sequences coding for HBsAg and HBcAg were detected by alkaline phosphatase-conjugated, single-stranded synthetic gene-specific oligonucleotide probes revealing a larger number of copies in D7 DNA than in F8 DNA. Using a biotinylated probe for in situ hybridization, HBV DNA was found in the nuclei of all D7 cells with predominant localization to a single chromsome, but only in 10-20% of F8 cells. These observations demonstrate different integration patterns of HBV and DNA in two subclones derived from a transfected cell line and suggest that the amount of integrated HBV DNA is proportional to the amount of HBV antigens produced

  2. The asymptotic hadron spectrum, anti-nuclei, hyper-nuclei and quark phase

    International Nuclear Information System (INIS)

    Glendenning, N.K.

    1978-01-01

    The only hope of determining the hadronic spectrum in the high mass region is through a study of matter produced in very high energy nuclear collisions. Along the way, exotic nuclei, i.e., anti-nuclei and hyper-nuclei may be produced in appreciable numbers, and the detection of a quark phase may be possible. (orig.) [de

  3. Gamow-Teller decay of T = 1 nuclei to odd-odd N = Z nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Lisetskiy, A F [National Superconducting Cyclotron Laboratory, MSU, East Lansing, MI 48824 (United States); Gelberg, A [Institute for Nuclear Physics, University of Cologne, 50937 Cologne (Germany); Institute of Physical and Chemical Reasearch (RIKEN), Wako, 351-0198 (Japan); Brentano, P von [Institute for Nuclear Physics, University of Cologne, 50937 Cologne (Germany)

    2005-01-01

    Transition strengths of Gamow-Teller decay of T{sub z} = {+-}1 nuclei to N = Z odd-odd nuclei have been calculated in a two-nucleon approximation for spherical and deformed nuclei. The results obtained for the latter are quite close to the values obtained by full-space shell-model calculations and to the experiment.

  4. N-cadherin is overexpressed in Crohn's stricture fibroblasts and promotes intestinal fibroblast migration.

    LENUS (Irish Health Repository)

    Burke, John P

    2012-02-01

    BACKGROUND: Intestinal fibroblasts mediate stricture formation in Crohn\\'s disease (CD). Transforming growth factor-beta (TGF-beta) is important in fibroblast activation, while cell attachment and migration is regulated by the adhesion molecule N-cadherin. The aim of this study was to investigate the expression and function of N-cadherin in intestinal fibroblasts in patients with fibrostenosing CD. METHODS: Intestinal fibroblasts were cultured from seromuscular biopsies from patients undergoing resection for terminal ileal fibrostenosing CD (n = 14) or controls patients (n = 8). N-cadherin expression was assessed using Western blot and quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Fibroblasts were stimulated with TGF-beta and selective pathway inhibitors Y27632, PD98050, and LY294002 were used to examine the Rho\\/ROCK, ERK-1\\/2, and Akt signaling pathways, respectively. Cell migration was assessed using a scratch wound assay. N-cadherin was selectively overexpressed using a plasmid. RESULTS: Fibroblasts from fibrostenosing CD express increased constitutive N-cadherin mRNA and protein and exhibit enhanced basal cell migration relative to those from directly adjacent normal bowel. Control fibroblasts treated with TGF-beta induced N-cadherin in a dose-dependent manner which was inhibited by Rho\\/ROCK and Akt pathway modulation. Control fibroblasts exhibited enhanced cell migration in response to treatment with TGF-beta or transfection with an N-cadherin plasmid. CONCLUSIONS: Fibroblasts from strictures in CD express increased constitutive N-cadherin and exhibit enhanced basal cell migration. TGF-beta is a potent inducer of N-cadherin in intestinal fibroblasts resulting in enhanced cell migration. The TGF-beta-mediated induction of N-cadherin may potentiate Crohn\\'s stricture formation.

  5. Male Infertility

    Science.gov (United States)

    ... hypothalamus, pituitary, thyroid and adrenal glands. Low testosterone (male hypogonadism) and other hormonal problems have a number of possible underlying causes. Defects of tubules that transport sperm. Many ... syndrome — in which a male is born with two X chromosomes and one ...

  6. Composite hadrons and relativistic nuclei

    International Nuclear Information System (INIS)

    Blankenbecler, R.

    1978-01-01

    Lectures are presented describing a model of hadronic scattering at large momentum transfer, either transverse or longitudinal. This model emphasizes in this regime the importance of forces involving the interchange of constituents of the hadrons, hence its name, the constituent interchange model CIM. The CIM is a rearrangement of standard perturbation theory to take into account the fact that the binding force is very strong in color singlet states (singlet dominance). The hard scattering expansion, incoherence problems, nuclear wave functions and counting rules, interaction between nuclei, pion and proton yields and form factors, structure functions and nonscaling, massive lepton pairs, hadrons at large transverse momentum, and quark-quark scattering are treated. 49 references

  7. Neutron halo in deformed nuclei

    International Nuclear Information System (INIS)

    Zhou Shangui; Meng Jie; Ring, P.; Zhao Enguang

    2010-01-01

    Halo phenomena in deformed nuclei are investigated within a deformed relativistic Hartree Bogoliubov (DRHB) theory. These weakly bound quantum systems present interesting examples for the study of the interdependence between the deformation of the core and the particles in the halo. Contributions of the halo, deformation effects, and large spatial extensions of these systems are described in a fully self-consistent way by the DRHB equations in a spherical Woods-Saxon basis with the proper asymptotic behavior at a large distance from the nuclear center. Magnesium and neon isotopes are studied and detailed results are presented for the deformed neutron-rich and weakly bound nucleus 44 Mg. The core of this nucleus is prolate, but the halo has a slightly oblate shape. This indicates a decoupling of the halo orbitals from the deformation of the core. The generic conditions for the occurrence of this decoupling effects are discussed.

  8. Order against chaos in nuclei

    International Nuclear Information System (INIS)

    Soloviev, V.G.

    1995-01-01

    Order and chaos and order-to-chaos transition are treated in terms of nuclear wave functions. A quasiparticle-phonon interaction is responsible for the fragmentation of one- and many-quasiparticle and phonon states and for the mixing of closely spaced states. Complete damping of one-quasiparticle states cannot be considered as a transition to chaos due to large many-quasiparticle or quasiparticle-phonon terms in their wave functions. An experimental investigation of the strength distribution of many-quasiparticle and quasiparticle-phonon states should uncover a new region of a regularity in nuclei at intermediate excitation energy. A chaotic behaviour of nuclear states can be shifted to higher excitation energies. ((orig.))

  9. Relativistic description of atomic nuclei

    International Nuclear Information System (INIS)

    Krutov, V.A.

    1985-01-01

    Papers on the relativistic description of nuclei are reviewed. The Brown and Rho ''small'' bag'' model is accepted for hardrons. Meson exchange potentials of the nucleon-nucleon interaction have been considered. Then the transition from a system of two interacting nucleons has been performed to the relativistic nucleus description as a multinucleon system on the basis of OBEP (one-boson exchange potential). The proboem of OPEP (one-pion-exchange potential) inclusion to a relativistic scheme is discussed. Simplicity of calculations and attractiveness of the Walecka model for specific computations and calculations was noted. The relativistic model of nucleons interacting through ''effective'' scalar and vector boson fields was used in the Walacka model for describing neutronaand nuclear mater matters

  10. Electric quadrupole strength in nuclei

    International Nuclear Information System (INIS)

    Kirson, M.W.

    1979-01-01

    Isoscalar electric quadrupole strength distributions in nuclei are surveyed, and it is concluded that the strength is shared, in most cases, roughly equally between low-lying transitions and the giant quadrupole state. The same is not true of the isovector case. A simple extension of the schematic model gives a remarkably successul description of the data, and emphasizes the vital importance of the coupling between high-lying and low-lying quadrupole modes. The standadrd simple representation of the giant quadrupole resonance as produced by operating on the nuclear ground state with the quadrupole transition operator is not applicable to the isoscalar case. It is suggested that giant resonances fall into broad classes of similar states, with considerable qualitative differences between the distinct classes. (author)

  11. Cavitation Nuclei: Experiments and Theory

    DEFF Research Database (Denmark)

    Mørch, Knud Aage

    2009-01-01

    The Swedish astrophysicist and Nobel Prize winner Hannes Alfven said: Theories come and go - the experiment is here forever. Often a theory, which we set up to describe an observed physical phenomenon, suffers from the lack of knowledge of decisive parameters, and therefore at best the theory...... becomes insufficient. Contrary, the experiment always reveals nature itself, though at prevailing experimental conditions. With essential parameters being out of control and even maybe unidentified, apparently similar experiments may deviate way beyond our expectations. However, these discrepancies offer...... us a chance to reflect on the character of the unknown parameters. In this way non-concordant experimental results may hold the key to the development of better theories - and to new experiments for the testing of their validity. Cavitation and cavitation nuclei are phenomena of that character....

  12. [The frequency of sex chromatine occurring in cell nuclei of internal organs determined by the smear method (author's transl)].

    Science.gov (United States)

    Michailow, R

    1975-09-05

    The frequency of sex chromatine occurring in cell nuclei of twelve organs from 25 male and female corpses was determined using the smear method. It was found to be about 60% in the case of female, and about 6% in the case of male corpses.

  13. Femtometer toroidal structures in nuclei

    International Nuclear Information System (INIS)

    Forest, J.L.; Pandharipande, V.R.; Pieper, S.C.; Wiringa, R.B.; Schiavilla, R.; Arriaga, A.

    1996-01-01

    The two-nucleon density distributions in states with isospin T=0, spin S=1, and projection M S =0 and ±1 are studied in 2 H, 3,4 He, 6,7 Li, and 16 O. The equidensity surfaces for M S =0 distributions are found to be toroidal in shape, while those of M S =±1 have dumbbell shapes at large density. The dumbbell shapes are generated by rotating tori. The toroidal shapes indicate that the tensor correlations have near maximal strength at r 3 He, 4 He, and 6 Li. The toroidal distribution has a maximum-density diameter of ∼1 fm and a half-maximum density thickness of ∼0.9 fm. Many realistic models of nuclear forces predict these values, which are supported by the observed electromagnetic form factors of the deuteron, and also predicted by classical Skyrme effective Lagrangians, related to QCD in the limit of infinite colors. Due to the rather small size of this structure, it could have a revealing relation to certain aspects of QCD. Experiments to probe this structure and its effects in nuclei are suggested. Pair distribution functions in other T,S channels are also discussed; those in T,S=1,1 have anisotropies expected from one-pion-exchange interactions. The tensor correlations in T,S=0,1 states are found to deplete the number of T,S=1,0 pairs in nuclei and cause a reduction in nuclear binding energies via many-body effects. copyright 1996 The American Physical Society

  14. Quarks and mesons in nuclei

    International Nuclear Information System (INIS)

    Rho, M.

    1981-01-01

    Quantum chromodynamics is believed to be candidate theory for the strong interactions and contains as its ingredients spinor quark fields and vector gluons, none of which can perhaps be ever liberated and detected in laboratories. A nucleus consists of nucleons bound by nuclear force which are however separately observable and which seem to preserve their identities even under extreme conditions. An intriguing question is: when compressed to high densities or heated to high temperature, at what point does a nuclear matter cease to be describable in terms of nucleon and meson degrees of freedom, but become a plasma of quarks and gluons; and how does this transition occur. This is not an idle question. If quarks and gluons are never to be observed isolated, then it may be that at low energies (or at low densities) they are not the right variables to do physics with. Instead hadrons must be. On the other hand, asymptotic freedom - the unique property of non-abelian gauge theories to which QCD belongs that quark-gluon and gluon-gluon interactions get weaker at short distances - tells us that at some large matter density the matter must necessarily be in the form of quark gas interacting only weakly. This means that a change in degrees of freedom must take place. We would like to know where this occurs and how. In this talk, I would like to address to this question by discussing first the large success we have had in understanding the role that mesons play in finite nuclei and nuclear matter and then attempting to correlate nucleon and meson degrees of freedom to quark-gluon degrees of freedom. In my opinion we are now at a stage where we feel fairly confident in our understanding of nucleon-meson structure of nuclei and nuclear matter and any further progress in deeper understanding of nuclear dynamics - and strong interactions - must come from QCD or its effective version, bags or strings. (orig.)

  15. Mean-field models and exotic nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Bender, M; Buervenich, T; Maruhn, J A; Greiner, W [Inst. fuer Theoretische Physik, Univ. Frankfurt (Germany); Rutz, K [Inst. fuer Theoretische Physik, Univ. Frankfurt (Germany); [Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany); Reinhard, P G [Inst. fuer Theoretische Physik, Univ. Erlangen (Germany)

    1998-06-01

    We discuss two widely used nuclear mean-field models, the relativistic mean-field model and the (nonrelativistic) Skyrme-Hartree-Fock model, and their capability to describe exotic nuclei. Test cases are superheavy nuclei and neutron-rich Sn isotopes. New information in this regime helps to fix hitherto loosely determined aspects of the models. (orig.)

  16. High-spin excitations of atomic nuclei

    International Nuclear Information System (INIS)

    Xu Furong; National Laboratory of Heavy Ion Physics, Lanzhou; Chinese Academy of Sciences, Beijing

    2004-01-01

    The authors used the cranking shell model to investigate the high-spin motions and structures of atomic nuclei. The authors focus the collective rotations of the A∼50, 80 and 110 nuclei. The A∼50 calculations show complicated g spectroscopy, which can have significant vibration effects. The A≅80 N≅Z nuclei show rich shape coexistence with prolate and oblate rotational bands. The A≅110 nuclei near the r-process path can have well-deformed oblate shapes that become yrast and more stable with increasing rotational frequency. As another important investigation, the authors used the configuration-constrained adiabatic method to calculate the multi-quasiparticle high-K states in the A∼130, 180 and superheavy regions. The calculations show significant shape polarizations due to quasi-particle excitations for soft nuclei, which should be considered in the investigations of high-K states. The authors predicted some important high-K isomers, e.g., the 8 - isomers in the unstable nuclei of 140 Dy and 188 Pb, which have been confirmed in experiments. In superheavy nuclei, our calculations show systematic existence of high-K states. The high-K excitations can increase the productions of synthesis and the survival probabilities of superheavy nuclei. (authors)

  17. Microscopic Cluster Theory for Exotic Nuclei

    International Nuclear Information System (INIS)

    Tomaselli, M; Kuehl, T; Ursescu, D; Fritzsche, S

    2006-01-01

    For a better understanding of the dynamics of complex exotic nuclei it is of crucial importance to develop a practical microscopic theory easy to be applied to a wide range of masses. In this paper we propose to calculate the structure of neutron-rich nuclei within a dynamic model based on the EoM theory

  18. Reentrainment of radioactive nuclei from filters

    International Nuclear Information System (INIS)

    Dincklage, R.-D. von

    1982-01-01

    The possible relevance of atomic phenomena for the reentrainment of radioactive nuclei is discussed. The considerations are based on the coulombic fragmentation mechanism. Nuclei of potential interest in reprocessing technology are identified. Future experiments have been shown to be of definite need in this field. (author)

  19. Thermodynamics of pairing phase transition in nuclei

    International Nuclear Information System (INIS)

    Karim, Afaque; Ahmad, Shakeb

    2014-01-01

    The pairing gaps, pairing energy, heat capacity and entropy are calculated within BCS (Bardeen- Cooper-Schrieffer) based quasi particle approach, including thermal fluctuations on pairing field within pairing model for all nuclei (light, medium, heavy and super heavy nuclei). Quasi particles approach in BCS theory was introduced and reformulated to study various properties. For thermodynamic behavior of nuclei at finite temperatures, the anomalous averages of creation and annihilation operators are introduced. It is solved self consistently at finite temperatures to obtain BCS Hamiltonian. After doing unitary transformation, we obtained the Hamiltonian in the diagonal form. Thus, one gets temperature dependence gap parameter and pairing energy for nuclei. Moreover, the energy at finite temperatures is the sum of the condensation energy and the thermal energy of fermionic quasi particles. With the help of BCS Hamiltonian, specific heat, entropy and free energy are calculated for different nuclei. In this paper the gap parameter occupation number and pairing energy as a function of temperature which is important for all the light, medium, heavy and super heavy nuclei is calculated. Moreover, the various thermo dynamical quantities like specific heat, entropy and free energy is also obtained for different nuclei. Thus, the thermodynamics of pairing phase transition in nuclei is studied

  20. Mean-field models and exotic nuclei

    International Nuclear Information System (INIS)

    Bender, M.; Buervenich, T.; Maruhn, J.A.; Greiner, W.; Rutz, K.; Reinhard, P.G.

    1998-01-01

    We discuss two widely used nuclear mean-field models, the relativistic mean-field model and the (nonrelativistic) Skyrme-Hartree-Fock model, and their capability to describe exotic nuclei. Test cases are superheavy nuclei and neutron-rich Sn isotopes. New information in this regime helps to fix hitherto loosely determined aspects of the models. (orig.)

  1. Static and dynamical properties of hot nuclei

    International Nuclear Information System (INIS)

    Suraud, E.

    1990-01-01

    We briefly review our understanding of the formation of excited/hot nuclei in heavy-ion collisions at some tens of MeV/A. We recall the major theoretical frameworks used for describing as well the entrance channel of the reaction as the structure properties of hot nuclei. We finally focus on multifragmentation within insisting upon the theoretical challenge it does represent

  2. Masses of nuclei close to the dripline

    International Nuclear Information System (INIS)

    Herfurth, F.; Blaum, K.; Audi, G.; Lunney, D.; Beck, D.; Kluge, H.J.; Rodriguez, D.; Sikler, G.; Weber, C.; Bollen, G.; Schwarz, S.; Kellerbauer, A.

    2003-01-01

    Mass measurements of radioactive nuclides are one of the cornerstones of our understanding of the nucleus. The Penning trap spectrometer ISOLTRAP performs direct mass measurements far away from the valley of stability, as well as high-precision measurements of key nuclei to anchor long decay chains. Both schemes provide valuable information on the dripline itself and on nuclei in its close vicinity. (orig.)

  3. Quasars, Seyfert galaxies and active galactic nuclei

    International Nuclear Information System (INIS)

    Osterbrock, D.E.

    1987-01-01

    This chapter is devoted to the spectroscopic methods for analyzing the observed plasma in the nuclei of quasars, Seyfert galazies, and active galactic nuclei. Both the narrow-line region and the broad-line region are discussed. Physical models are presented

  4. Single Particle Entropy in Heated Nuclei

    International Nuclear Information System (INIS)

    Guttormsen, M.; Chankova, R.; Hjorth-Jensen, M.; Rekstad, J.; Siem, S.; Sunde, A. C.; Syed, N. U. H.; Agvaanluvsan, U.; Schiller, A.; Voinov, A.

    2006-01-01

    The thermal motion of single particles represents the largest contribution to level density (or entropy) in atomic nuclei. The concept of single particle entropy is presented and shown to be an approximate extensive (additive) quantity for mid-shell nuclei. A few applications of single particle entropy are demonstrated

  5. Quantum phase transitions in atomic nuclei

    International Nuclear Information System (INIS)

    Zamfir, N.V.

    2005-01-01

    Studies of quantum phase transitions in mesoscopic systems and applications to atomic nuclei are presented. Analysis in terms of the Interacting Boson Model shows that the main features persist even for moderate number of particles. Experimental evidence in rare-earth nuclei is discussed. New order and control parameters for systems with the same number of particles are proposed. (author)

  6. Structure and clusters of light unstable nuclei

    International Nuclear Information System (INIS)

    En'yo, Yoshiko

    2010-01-01

    As it is known, cluster structures are often observed in light nuclei. In the recent evolution of unstable nuclear research (on nuclei having unbalanced number of neutron and proton) further new types of clusters are coming to be revealed. In this report, structures of light unstable nuclei and some of the theoretical models to describe them are reviewed. The following topics are picked up. 1. Cluster structure and theoretical models, 2. Cluster structure of unstable nuclei (low excited state). 3. Cluster structure of neutron excess beryllium isotopes. 4. Cluster gas like state in C isotope. 5. Dineutron structure of He isotopes. Numbers of strange nuclear structures of light nuclei are illustrated. Antisymmetrized molecular dynamics (AMD) is the recently developed theoretical framework which has been successfully used in heavy ion reactions and nuclear structure studies. Successful application of AMD to the isotopes of Be, B and C are illustrated. (S. Funahashi)

  7. Structure of Light Neutron-rich Nuclei

    International Nuclear Information System (INIS)

    Dlouhy, Zdenek

    2007-01-01

    In this contribution we searched for irregularities in various separation energies in the frame of mass measurement of neutron-rich nuclei at GANIL. On this basis we can summarize that the new doubly magic nuclei are 8 He, 22 O and 24 O. They are characterized by extra stability and, except 24 O, they cannot accept and bind additional neutrons. However, if we add to these nuclei a proton we obtain 9 Li and 25 F which are the core for two-neutron halo nucleus 11 Li and enables that fluorine can bound even 6 more neutrons, respectively. In that aspect the doubly magic nuclei in the neutron-rich region can form the basis either for neutron halo or very neutron-rich nuclei. (Author)

  8. Strength of Coriolis Coupling in actinide nuclei

    International Nuclear Information System (INIS)

    Peker, L.K.; Rasmussen, J.O.; Hamilton, J.H.

    1982-01-01

    Coriolis Coupling V/sub cor/ plays an important role in deformed nuclei. V/sub cor/ is proportional to h 2 /J[j (j + 1) -Ω (Ω + 1)]/sup 1/2/ and therefore is particularly significant in the nuclei with large j and low Ω Nilsson levels close to Fermi surface: n(i/sub 13/2/) in A = 150 to 170 rare-earth nuclei and p(i/sub 13/2/) and n(j/sub 15/2/) in A greater than or equal to 224 actinide nuclei. Because of larger j (n(j/sub 15/2/) versus n(i/sub 13/2/)) and smaller deformations (β approx. = 0.22 versus β 0.28) it was reasonable to expect that in actinide nuclei Coriolis effects are stronger than in the rare earth nuclei. Recently it was realized that the strength of observed Coriolis effects depends not only on the genuine Coriolis Coupling but also on the interplay between Coriolis ad pairing forces which leads to an interference between the wave functions of two mixing rotational bands. As a consequence the effective interaction V/sub eff/ of both bands is an oscillating function of the degree of shell filling (or chemical potential lambda F). It was shown that in the rare earth nuclei this interference strongly influenced conclusions about the trends in the Coriolis coupling strength and explained many of the observed band-mixing features (the sharpness of back banding curves, details of the blocking effect etc.). From theoretical analysis it was concluded that in the majority of actinide nuclei the effective interaction V/sub eff/ is strong, and therefore the Coriolis band-mixing have to be very strong. In this paper we would like to demonstrate that contrary to these predictions experimental data suggest that Coriolis band mixing in studied actinide nuclei is relatively weak and possibly significantly weaker than in rare earth nuclei

  9. Testosterone metabolism of fibroblasts grown from prostatic carcinoma, benign prostatic hyperplasia and skin fibroblasts

    International Nuclear Information System (INIS)

    Schweikert, H.U.; Hein, H.J.; Romijn, J.C.; Schroeder, F.H.

    1982-01-01

    The metabolism of [1,2,6,7-3H]testosterone was assessed in fibroblast monolayers derived from tissue of 5 prostates with benign hyperplasia (BPH), 4 prostates with carcinoma (PC), and 3 biopsy samples of skin, 2 nongenital skin (NG) and 1 genital skin. The following metabolites could be identified: androstanedione androstenedione, dihydrotestosterone, androsterone, epiandrosterone, androstane-3 alpha, 17 beta-diol and androstane-3 beta, 17 beta-diol. Testosterone was metabolized much more rapidly in fibroblasts originating from prostatic tissue than in fibroblasts derived from NG. A significantly higher formation of 5 alpha-androstanes and 3 alpha-hydroxysteroids could be observed in fibroblasts from BPH as compared to PC. 17-ketosteroid formation exceeded 5 alpha-androstane formation in BPH, whereas 5 alpha-reduction was the predominant pathway in fibroblasts grown from PC and NG. Since testosterone metabolism in fibroblasts of prostatic origin therefore resembles in many aspects that in whole prostatic tissue, fibroblasts grown from prostatic tissues might be a valuable tool for further investigation of the pathogenesis of human BPH and PC

  10. Typical xeroderma pigmentosum complementation group A fibroblasts have detectable ultraviolet light-induced unscheduled DNA synthesis

    International Nuclear Information System (INIS)

    Petinga, R.A.; Andrews, A.D.; Robbins, J.H.; Tarone, R.E.

    1977-01-01

    Ultraviolet-induced nuclear uptake of tritiated thymidine [ 3 H]dThd demonstrable by autoradiography in non-synthesis phases of the cell cycle is known as unscheduled DNA synthesis and reflects repair replication of ultraviolet-damaged DNA. We have reported that the rate of any such unscheduled DNA synthesis in typical group A xeroderma pigmentosum fibroblasts, if present, is less than 2% of the normal rate. We have now performed experiments to determine whether these fibroblasts have any unscheduled DNA synthesis. Fibroblast coverslip cultures of four xeroderma pigmentosum group A strains were prepared. Irradiated (254 nm ultraviolet light) and unirradiated cultures from each strain were incubated with [ 3 H]dThd at 37degC, and autoradiograms were prepared using NTB-3 emulsion. A nuclear grain count was made of 100 consecutive nuclei of non-S-phase irradiated and unirradiated cells. A slide background grain count was simultaneously made from an acellular area adjacent to each cell analyzed. When a strain's irradiated and unirradiated autoradiograms having similar slide background grain count averages were compared, the nuclear grain count average of the irradiated cells was always higher than that of the unirradiated cells. This ultraviolet-induced increase in the mean nuclear grain count ranged from 0.4 to 1.3% of that given by normal non-xeroderma pigmentosum fibroblasts and was not reduced by 10 -2 M hydroxyurea. Planimetric studies showed that the ultraviolet-induced increase in nuclear grain count is not due to an increased nuclear area in irradiated cells. We conclude that these typical group A xeroderma pigmentosum strains perform very low, but detectable, ultraviolet-induced unscheduled DNA synthesis which probably reflects repair replication. We cannot, however, determine if there are significantly different rates of ultraviolet-induced unscheduled DNA synthesis among these ultraviolet strains

  11. Hedgehog signaling contributes to basic fibroblast growth factor-regulated fibroblast migration

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Zhong Xin [School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China); Sun, Cong Cong [School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China); Wenzhou People' s Hospital, Wenzhou, Zhejiang (China); Ting Zhu, Yu; Wang, Ying; Wang, Tao; Chi, Li Sha; Cai, Wan Hui [School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China); Zheng, Jia Yong [Wenzhou People' s Hospital, Wenzhou, Zhejiang (China); Zhou, Xuan [Ningbo First Hospital, Ningbo, Zhejiang (China); Cong, Wei Tao [School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China); Li, Xiao Kun, E-mail: proflxk@163.com [School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China); Jin, Li Tai, E-mail: jin_litai@126.com [School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China)

    2017-06-15

    Fibroblast migration is a central process in skin wound healing, which requires the coordination of several types of growth factors. bFGF, a well-known fibroblast growth factor (FGF), is able to accelerate fibroblast migration; however, the underlying mechanism of bFGF regulation fibroblast migration remains unclear. Through the RNA-seq analysis, we had identified that the hedgehog (Hh) canonical pathway genes including Smoothened (Smo) and Gli1, were regulated by bFGF. Further analysis revealed that activation of the Hh pathway via up-regulation of Smo promoted fibroblast migration, invasion, and skin wound healing, but which significantly reduced by GANT61, a selective antagonist of Gli1/Gli2. Western blot analyses and siRNA transfection assays demonstrated that Smo acted upstream of phosphoinositide 3-kinase (PI3K)-c-Jun N-terminal kinase (JNK)-β-catenin to promote cell migration. Moreover, RNA-seq and qRT-PCR analyses revealed that Hh pathway genes including Smo and Gli1 were under control of β-catenin, suggesting that β-catenin turn feedback activates Hh signaling. Taken together, our analyses identified a new bFGF-regulating mechanism by which Hh signaling regulates human fibroblast migration, and the data presented here opens a new avenue for the wound healing therapy. - Highlights: • bFGF regulates Hedgehog (Hh) signaling in fibroblasts. • The Smo and Gli two master regulators of Hh signaling positively regulate fibroblast migration. • Smo facilitates β-catenin nuclear translocation via activation PI3K/JNK/GSK3β. • β-catenin positively regulates fibroblast cell migration and the expression of Hh signaling genes including Smo and Gli.

  12. Hedgehog signaling contributes to basic fibroblast growth factor-regulated fibroblast migration

    International Nuclear Information System (INIS)

    Zhu, Zhong Xin; Sun, Cong Cong; Ting Zhu, Yu; Wang, Ying; Wang, Tao; Chi, Li Sha; Cai, Wan Hui; Zheng, Jia Yong; Zhou, Xuan; Cong, Wei Tao; Li, Xiao Kun; Jin, Li Tai

    2017-01-01

    Fibroblast migration is a central process in skin wound healing, which requires the coordination of several types of growth factors. bFGF, a well-known fibroblast growth factor (FGF), is able to accelerate fibroblast migration; however, the underlying mechanism of bFGF regulation fibroblast migration remains unclear. Through the RNA-seq analysis, we had identified that the hedgehog (Hh) canonical pathway genes including Smoothened (Smo) and Gli1, were regulated by bFGF. Further analysis revealed that activation of the Hh pathway via up-regulation of Smo promoted fibroblast migration, invasion, and skin wound healing, but which significantly reduced by GANT61, a selective antagonist of Gli1/Gli2. Western blot analyses and siRNA transfection assays demonstrated that Smo acted upstream of phosphoinositide 3-kinase (PI3K)-c-Jun N-terminal kinase (JNK)-β-catenin to promote cell migration. Moreover, RNA-seq and qRT-PCR analyses revealed that Hh pathway genes including Smo and Gli1 were under control of β-catenin, suggesting that β-catenin turn feedback activates Hh signaling. Taken together, our analyses identified a new bFGF-regulating mechanism by which Hh signaling regulates human fibroblast migration, and the data presented here opens a new avenue for the wound healing therapy. - Highlights: • bFGF regulates Hedgehog (Hh) signaling in fibroblasts. • The Smo and Gli two master regulators of Hh signaling positively regulate fibroblast migration. • Smo facilitates β-catenin nuclear translocation via activation PI3K/JNK/GSK3β. • β-catenin positively regulates fibroblast cell migration and the expression of Hh signaling genes including Smo and Gli.

  13. Melanoma Cells Can Adopt the Phenotype of Stromal Fibroblasts and Macrophages by Spontaneous Cell Fusion in Vitro.

    Science.gov (United States)

    Kemény, Lajos V; Kurgyis, Zsuzsanna; Buknicz, Tünde; Groma, Gergely; Jakab, Ádám; Zänker, Kurt; Dittmar, Thomas; Kemény, Lajos; Németh, István B

    2016-06-02

    After the removal of primary cutaneous melanoma some patients develop local recurrences, even after having histologically tumor-free re-excision. A potential explanation behind this phenomenon is that tumor cells switch their phenotype, making their recognition via standard histopathological assessments extremely difficult. Tumor-stromal cell fusion has been proposed as a potential mechanism for tumor cells to acquire mesenchymal traits; therefore, we hypothesized that melanoma cells could acquire fibroblast- and macrophage-like phenotypes via cell fusion. We show that melanoma cells spontaneously fuse with human dermal fibroblasts and human peripheral blood monocytes in vitro. The hybrid cells' nuclei contain chromosomes from both parental cells and are indistinguishable from the parental fibroblasts or macrophages based on their morphology and immunophenotype, as they could lose the melanoma specific MART1 marker, but express the fibroblast marker smooth muscle actin or the macrophage marker CD68. Our results suggest that, by spontaneous cell fusion in vitro, tumor cells can adopt the morphology and immunophenotype of stromal cells while still carrying oncogenic, tumor-derived genetic information. Therefore, melanoma-stromal cell fusion might play a role in missing tumor cells by routine histopathological assessments.

  14. Male Hypogonadism

    Science.gov (United States)

    ... the hormone that plays a key role in masculine growth and development during puberty — or has an ... Adulthood In adult males, hypogonadism may alter certain masculine physical characteristics and impair normal reproductive function. Signs ...

  15. Male Infertility

    Science.gov (United States)

    ... to have a baby? If treatment doesn’t work, what are our other options? Resources National Institute of Child Health and Human Development, What Causes Male Infertility? Last Updated: May 30, 2017 This ...

  16. Male contraception.

    Science.gov (United States)

    Amory, John K

    2016-11-01

    Although female contraceptives are very effective at preventing unintended pregnancy, some women can not use them because of health conditions or side-effects, leaving some couples without effective contraceptive options. In addition, many men wish to take active responsibility for family planning. Thus, there is a great need for male contraceptives to prevent unintended pregnancies, of which 80-90 million occur annually. At present, effective male contraceptive options are condoms and vasectomy, which are not ideal for all men. Therefore, efforts are under way to develop novel male contraceptives. This paper briefly reviews the advantages and disadvantages of condoms and vasectomies and then discusses the research directed toward development of novel methods of male contraception. Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  17. Condoms - male

    Science.gov (United States)

    Prophylactics; Rubbers; Male condoms; Contraceptive - condom; Contraception - condom; Barrier method - condom ... your health care provider or pharmacy about emergency contraception ("morning-after pills"). PROBLEMS WITH CONDOM USE Some ...

  18. Male contraception

    OpenAIRE

    Mathew, Vivek; Bantwal, Ganapathi

    2012-01-01

    Contraception is an accepted route for the control of population explosion in the world. Traditionally hormonal contraceptive methods have focused on women. Male contraception by means of hormonal and non hormonal methods is an attractive alternative. Hormonal methods of contraception using testosterone have shown good results. Non hormonal reversible methods of male contraception like reversible inhibition of sperm under guidanceare very promising. In this article we have reviewed the curren...

  19. A fibroblast-associated antigen: Characterization in fibroblasts and immunoreactivity in smooth muscle differentiated stromal cells

    DEFF Research Database (Denmark)

    Rønnov-Jessen, Lone; Celis, Julio E.; van Deurs, Bo

    1992-01-01

    major brands migrating at apparent Mr of 38,000, 45,000, and 80,000, in addition to many minor bands between Mr 45,000 and 97,000, including Mr 52,000. The Mr 45,000 and 38,000 were associated with the cell membrane and Mr 52,000 as well as Mr 38,000 were associated with the lysosomes. The 1B10......Fibroblasts with smooth muscle differentiation are frequently derived from human breast tissue. Immunofluorescence cytochemistry of a fibroblast-associated antigen recognized by a monoclonal antibody (MAb), 1B10, was analyzed with a view to discriminating smooth muscle differentiated fibroblasts...

  20. Male sexuality.

    Science.gov (United States)

    Ginsberg, Terrie B

    2010-05-01

    It should be recognized that sexuality in the aging male is of such import that a complete sexual history must be performed. By taking a complete sexual history, facts can be obtained that will allow for appropriate focus relating to a holistic evaluation and will enable us to dispel antiquated sexual myths pertaining to the aging male. If initiated by the history taker, questions concerning sexuality may be discussed more comfortably by the patient. Erectile dysfunction, male sexual response cycle, testosterone, sexually transmitted diseases, human immunodeficiency virus, long-term illness, along with religion and culture are explored in this article with the aim of improving one's knowledge base, self reflection, and awareness of the importance of male sexuality. A complete understanding and appreciation of the aging male's medical history, surgical history, social history, and emotional history as well as his sexual, cultural, and religious concepts will allow the health care provider to better analyze information, and to recommend and provide appropriate advice and treatment to the aging male patient. Copyright 2010 Elsevier Inc. All rights reserved.

  1. Radiation response in vitro of fibroblasts from a Fanconi anemia patient with marked clinical radiosensitivity

    Energy Technology Data Exchange (ETDEWEB)

    Djuzenova, C.; Flentje, M. [Dept. of Radiotherapy, Univ. of Wuerzburg, Wuerzburg (Germany); Plowman, P.N. [Radiotherapy/Clinical Oncology, St. Bartholomew' s Hospital, London (United Kingdom)

    2004-12-01

    Background: fanconi anemia (FA) is an autosomal recessive chromosome instability disorder characterized by progressive pancytopenia and cancer susceptibility. The risks of radiation therapy in FA patients who have cancer remain to be investigated. Recently, Marcou et al. (2001) reported a case of severe clinical radiosensitivity in a female FA patient with a tonsillar squamous cell carcinoma treated by radiotherapy. By contrast, her in vitro irradiated skin fibroblasts revealed nearly normal radiosensitivity as determined by the colony survival assay. Material and methods: in view of this discrepancy, the radiation response of this particular FA fibroblast strain (designated 425BR) was further analyzed in the present study by means of the alkaline single-cell gel electrophoresis (Comet) assay, and also by the cytochalasin-blocked micronuclei (MN) test. In addition, the expression levels of DNA repair proteins, hMre11, Rad50, and Rad51, were investigated using Western blot and foci immunofluorescence staining. Results: the Comet assay revealed that the initial DNA fragmentation in irradiated FA cells was two times higher and the DNA rejoining process was three times slower than that in control (1BR3) fibroblasts. Moreover, although the baseline level of MNs was lower in FA cells than in controls, the FA fibroblasts were more prone (about two times) to MN production than control cells when irradiated with 2-4 Gy. Western blot analysis of the DNA repair proteins (hMre11, Rad50, and Rad51) did not reveal any abnormalities in protein expression levels or their migration patterns in the fibroblasts derived from an FA patient either before or after irradiation. At the same time, in vitro irradiated cells from the FA patient exhibited a significantly reduced number of nuclei with focally concentrated DNA repair Rad51 protein than in control cells. Conclusion: the increased DNA damage and MN induction in irradiated FA fibroblasts, and the reduction of the formation of DNA

  2. Radiation response in vitro of fibroblasts from a Fanconi anemia patient with marked clinical radiosensitivity

    International Nuclear Information System (INIS)

    Djuzenova, C.; Flentje, M.; Plowman, P.N.

    2004-01-01

    Background: fanconi anemia (FA) is an autosomal recessive chromosome instability disorder characterized by progressive pancytopenia and cancer susceptibility. The risks of radiation therapy in FA patients who have cancer remain to be investigated. Recently, Marcou et al. (2001) reported a case of severe clinical radiosensitivity in a female FA patient with a tonsillar squamous cell carcinoma treated by radiotherapy. By contrast, her in vitro irradiated skin fibroblasts revealed nearly normal radiosensitivity as determined by the colony survival assay. Material and methods: in view of this discrepancy, the radiation response of this particular FA fibroblast strain (designated 425BR) was further analyzed in the present study by means of the alkaline single-cell gel electrophoresis (Comet) assay, and also by the cytochalasin-blocked micronuclei (MN) test. In addition, the expression levels of DNA repair proteins, hMre11, Rad50, and Rad51, were investigated using Western blot and foci immunofluorescence staining. Results: the Comet assay revealed that the initial DNA fragmentation in irradiated FA cells was two times higher and the DNA rejoining process was three times slower than that in control (1BR3) fibroblasts. Moreover, although the baseline level of MNs was lower in FA cells than in controls, the FA fibroblasts were more prone (about two times) to MN production than control cells when irradiated with 2-4 Gy. Western blot analysis of the DNA repair proteins (hMre11, Rad50, and Rad51) did not reveal any abnormalities in protein expression levels or their migration patterns in the fibroblasts derived from an FA patient either before or after irradiation. At the same time, in vitro irradiated cells from the FA patient exhibited a significantly reduced number of nuclei with focally concentrated DNA repair Rad51 protein than in control cells. Conclusion: the increased DNA damage and MN induction in irradiated FA fibroblasts, and the reduction of the formation of DNA

  3. Role of periodontal ligament fibroblasts in osteoclastogenesis: a review

    NARCIS (Netherlands)

    Sokos, D.; Everts, V.; de Vries, T.J.

    2015-01-01

    During the last decade it has become clear that periodontal ligament fibroblasts may contribute to the in vitro differentiation of osteoclasts. We surveyed the current findings regarding their osteoclastogenesis potential. Periodontal ligament fibroblasts have the capacity to select and attract

  4. RADIO VARIABILITY IN SEYFERT NUCLEI

    International Nuclear Information System (INIS)

    Mundell, C. G.; Ferruit, P.; Nagar, N.; Wilson, A. S.

    2009-01-01

    Comparison of 8.4 GHz radio images of a sample of eleven, early-type Seyfert galaxies with previous observations reveals possible variation in the nuclear radio flux density in five of them over a seven year period. Four Seyferts (NGC 2110, NGC 3081, MCG -6-30-15, and NGC 5273) show a decline in their 8.4 GHz nuclear flux density between 1992 and 1999, while one (NGC 4117) shows an increase; the flux densities of the remaining six Seyferts (Mrk 607, NGC 1386, Mrk 620, NGC 3516, NGC 4968, and NGC 7465) have remained constant over this period. New images of MCG -5-23-16 are also presented. We find no correlation between radio variability and nuclear radio luminosity or Seyfert nuclear type, although the sample is small and dominated by type 2 Seyferts. Instead, a possible correlation between the presence of nuclear radio variability and the absence of hundred parsec-scale radio emission is seen, with four out of five marginally resolved or unresolved nuclei showing a change in nuclear flux density, while five out of six extended sources show no nuclear variability despite having unresolved nuclear sources. NGC 2110 is the only source in our sample with significant extended radio structure and strong nuclear variability (∼38% decline in nuclear flux density over seven years). The observed nuclear flux variability indicates significant changes are likely to have occurred in the structure of the nucleus on scales smaller than the VLA beam size (i.e., within the central ∼0.''1 (15 pc)), between the two epochs, possibly due to the appearance and fading of new components or shocks in the jet, consistent with previous detection of subparsec-scale nuclear structure in this Seyfert. Our results suggest that all Seyferts may exhibit variation in their nuclear radio flux density at 8.4 GHz, but that variability is more easily recognized in compact sources in which emission from the variable nucleus is not diluted by unresolved, constant flux density radio jet emission

  5. A new spin on nuclei

    International Nuclear Information System (INIS)

    Clark, R.; Wadsworth, B.

    1998-01-01

    Magnetic rotation is a new phenomenon that is forcing physicists to rethink their understanding of what goes on inside the nucleus The rotation of quantum objects has a long and distinguished history in physics. In 1912 the Danish scientist Niels Bjerrum was the first to recognize that the rotation of molecules is quantized. In 1938 Edward Teller and John Wheeler observed similar features in the spectra of excited nuclei, and suggested that this was caused by the nucleus rotating. But a more complete explanation had to wait until 1951, when Aage Bohr (the son of Niels) pointed out that rotation was a consequence of the nucleus deforming from its spherical shape. We owe much of our current understanding of nuclear rotation to the work of Bohr and Ben Mottelson, who shared the 1975 Nobel Prize for Physics with James Rainwater for developing a model of the nucleus that combined the individual and collective motions of the neutrons and protons inside the nucleus. What makes it possible for a nucleus to rotate? Quantum mechanically, a perfect sphere cannot rotate because it appears the same when viewed from any direction and there is no point of reference against which its change in position can be detected. To see the rotation the spherical symmetry must be broken to allow an orientation in space to be defined. For example, a diatomic molecule, which has a dumbbell shape, can rotate about the two axes perpendicular to its axis of symmetry. A quantum mechanical treatment of a diatomic molecule leads to a very simple relationship between rotational energy, E, and angular momentum. This energy is found to be proportional to J(J + 1), where J is the angular momentum quantum number. The molecule also has a magnetic moment that is proportional to J. These concepts can be applied to the atomic nucleus. If the distribution of mass and/or charge inside the nucleus becomes non-spherical then the nucleus will be able to rotate. The rotation is termed ''collective'' because many

  6. Symmetry and Phase Transitions in Nuclei

    International Nuclear Information System (INIS)

    Iachello, F.

    2009-01-01

    Phase transitions in nuclei have received considerable attention in recent years, especially after the discovery that, contrary to expectations, systems at the critical point of a phase transition display a simple structure. In this talk, quantum phase transitions (QPT), i.e. phase transitions that occur as a function of a coupling constant that appears in the quantum Hamiltonian, H, describing the system, will be reviewed and experimental evidence for their occurrence in nuclei will be presented. The phase transitions discussed in the talk will be shape phase transitions. Different shapes have different symmetries, classified by the dynamic symmetries of the Interacting Boson Model, U(5), SU(3) and SO(6). Very recently, the concept of Quantum Phase Transitions has been extended to Excited State Quantum Phase Transitions (ESQPT). This extension will be discussed and some evidence for incipient ESQPT in nuclei will be presented. Systems at the critical point of a phase transition are called 'critical systems'. Approximate analytic formulas for energy spectra and other properties of 'critical nuclei', in particular for nuclei at the critical point of the second order U(5)-SO(6) transition, called E(5), and along the line of first order U(5)-SU(3) transitions, called X(5), will be presented. Experimental evidence for 'critical nuclei' will be also shown. Finally, the microscopic derivation of shape phase transitions in nuclei within the framework of density functional methods will be briefly discussed.(author)

  7. Fibroblast growth factor 23 - et fosfatregulerende hormon

    DEFF Research Database (Denmark)

    Beck-Nielsen, Signe; Pedersen, Susanne Møller; Kassem, Moustapha

    2010-01-01

    Fibroblast growth factor 23 (FGF23) er et nyligt identificeret fosfatonin. FGF23's fysiologiske hovedfunktion er at opretholde normalt serumfosfat og at virke som et D-vitaminmodregulatorisk hormon. Sygdomme, der er koblet til forhøjet serum FGF23, er hypofosfatæmisk rakitis, fibrøs dysplasi og t...

  8. Cryopreservation of canine ovarian and testicular fibroblasts.

    Science.gov (United States)

    Yu, Il-Jeoung; Leibo, S P; Songsasen, Nucharin; Dresser, Betsy L; Kim, In-Shik

    2009-01-01

    To derive a practical procedure to store canine somatic cells, fibroblasts isolated from testicular or ovarian tissues were cryopreserved in 1.2 M ethylene glycol or in 1.2 M dimethylsulfoxide prepared in Dulbecco's Modified Eagle Medium as cryoprotectants, and were frozen either in plastic straws or vials. Thawed cells were cultured for 24 hr at 38.5 degree C in a humidified atmosphere of 5 percent CO2 95 percent air, and then their membrane integrity was assayed with a double fluorescent stain, Fertilight. In addition, frozen-thawed fibroblasts were cultured for 4 days, and then their functional survival was measured after staining small colonies with trypan blue. After freezing and thawing, membrane integrity of testicular fibroblasts was 55-70 percent and functional survival ranged from 20-40 percent. With frozen-thawed ovarian cells, the average membrane integrity was 55-75 percent and the average functional survival was 35-40 percent. When frozen in ethylene glycol, functional survival of ovarian fibroblasts was significantly higher than that of testicular cells (P less than 0.05). These methods should prove useful to preserve cells collected from canids in the wild.

  9. Neutron rich nuclei around 132Sn

    International Nuclear Information System (INIS)

    Bhattacharya, Sarmishtha

    2016-01-01

    The neutron rich nuclei with few particles or holes in 132 Sn have various experimental and theoretical interest to understand the evolution of nuclear structure around the doubly magic shell closure Z=50 and N=82. Some of the exotic neutron rich nuclei in this mass region are situated near waiting points in the r-process path and are of special astrophysical interest. Neutron rich nuclei near 132 Sn have been studied using fission fragment spectroscopy. The lifetime of low lying isomeric states have been precisely measured and the beta decay from the ground and isomeric states have been characterized using gamma-ray spectroscopy

  10. Collective models of transition nuclei Pt. 2

    International Nuclear Information System (INIS)

    Dombradi, Zs.

    1982-01-01

    The models describing the even-odd and odd-odd transition nuclei (nuclei of moderate ground state deformation) are reviewed. The nuclear core is described by models of even-even nuclei, and the interaction of a single particle and the core is added. Different models of particle-core coupling (phenomenological models, collective models, nuclear field theory, interacting boson-fermion model, vibration nucleon cluster model) and their results are discussed. New developments like dynamical supersymmetry and new research trends are summarized. (D.Gy.)

  11. Coulomb energy differences in mirror nuclei

    International Nuclear Information System (INIS)

    Lenzi, Silvia M

    2006-01-01

    By comparing the excitation energies of analogue states in mirror nuclei, several nuclear structure properties can be studied as a function of the angular momentum up to high spin states. They can be described in the shell model framework by including electromagnetic and nuclear isospin-non-conserving interactions. Calculations for the mirror energy differences in nuclei of the f 7/2 shell are described and compared with recent experimental data. These studies are extended to mirror nuclei in the upper sd and fp shells

  12. Bound states of Θ+ in nuclei

    International Nuclear Information System (INIS)

    Oset, E.; Cabrera, D.; Li, Q.B.; Magas, V.K.; Vicente Vacas, M.J.

    2005-01-01

    We study the binding energy and the width of the Θ + in nuclei, associated to the KN and KπN components. The first one leads to negligible contributions while the second one leads to a sizeable attraction, enough to bind the Θ + in nuclei. Pauli blocking and binding effects on the KN decay reduce considerably the Θ + decay width in nuclei and medium effects associated to the KπN component also lead to a very small width, as a consequence of which one finds separation between the bound levels considerably larger than the width of the states

  13. Is there chirality in atomic nuclei?

    International Nuclear Information System (INIS)

    Meng Jie

    2009-01-01

    Static chiral symmetries are common in nature, for example, the macroscopic spirals of snail shells, the microscopic handedness of certain molecules, and human hands. The concept of chirality in atomic nuclei was first proposed in 1997, and since then many efforts have been made to understand chiral symmetry and its spontaneous breaking in atomic nuclei. Recent theoretical and experimental progress in the verification of chirality in atomic nuclei will be reviewed, together with a discussion of the problems that await to be solved in the future. (authors)

  14. Bubble nuclei in relativistic mean field theory

    International Nuclear Information System (INIS)

    Shukla, A.; Aberg, S.; Patra, S.K.

    2011-01-01

    Bubble nuclei are characterized by a depletion of their central density, i.e. the formation of the proton or neutron void and subsequently forming proton or neutron bubble nuclei. Possibility of the formation of bubble nuclei has been explored through different nuclear models and in different mass regions. Advancements in experimental nuclear physics has led our experimental access to many new shapes and structures, which were inaccessible hitherto. In the present paper, the possibility of observing nuclear bubble in oxygen isotopes, particularly for 22 O has been studied

  15. Formation and decay of hot nuclei

    International Nuclear Information System (INIS)

    Tamain, B.

    1992-09-01

    The mechanisms involved in hot nuclei formation and decay and their eventual connexion with fundamental properties of nuclear matter are discussed, i.e. its equation of state is considered. After a brief review of the reactions in which hot nuclei can be formed, the variables which are used to describe them, the corresponding theoretical descriptions and their limits when extreme states are reached are discussed. Experimental evidences for hot nuclei formation are presented, with the corresponding decay properties used as signatures. (R.P.) 64 refs.; 25 figs.; 2 tabs

  16. Hot nuclei: high temperatures, high angular momenta

    International Nuclear Information System (INIS)

    Guerreau, D.

    1991-01-01

    A review is made of the present status concerning the production of hot nuclei above 5 MeV temperature, concentrating mainly on the possible experimental evidences for the attainment of a critical temperature, on the existence of dynamical limitations to the energy deposition and on the experimental signatures for the formation of hot spinning nuclei. The data strongly suggest a nuclear disassembly in collisions involving very heavy ions at moderate incident velocities. Furthermore, hot nuclei seem to be quite stable against rotation on a short time scale. (author) 26 refs.; 12 figs

  17. Evolution of planetary nebula nuclei

    International Nuclear Information System (INIS)

    Shaw, R.A.

    1985-01-01

    The evolution of planetary nebula nuclei (PNNs) is examined with the aid of the most recent available stellar evolution calculations and new observations of these objects. Their expected distribution in the log L-log T plane is calculated based upon the stellar evolutionary models of Paczynski, Schoenberner and Iben, the initial mass function derived by Miller and Scalo, and various assumptions concerning mass loss during post-main sequence evolution. The distribution is found to be insensitive both to the assumed range of main-sequence progenitor mass and to reasonable variations in the age and the star forming history of the galactic disk. Rather, the distribution is determined by the strong dependence of the rate of stellar evolution upon core mass, the steepness of the initial mass function, and to a lesser extent the finite lifetime of an observable planetary nebula. The theoretical distributions are rather different than any of those inferred from earlier observations. Possible observational selection effects that may be responsible are examined, as well as the intrinsic uncertainties associated with the theoretical model predictions. An extensive photometric and smaller photographic survey of southern hemisphere planetary nebulae (PNs) is presented

  18. Shape nuclei and nuclear reactions

    International Nuclear Information System (INIS)

    Yushkov, A.V.

    1975-01-01

    Experimental methods for obtaining the nucleus shape parameters are reviewed throughout the period of 1955-1975. Spatial properties of a nucleus, which can be directly or indirectly measured, are determined. They include: parameters of nucleus localization in space; parameters characterizing the nucleus nonsphericity; parameters of the nucleus nonaxiality. Dimensional parameters of a nucleus, namely, radius R and surface ΔR are derived from electron scattering. The deformation sign is indirectly obtained in the experiments. Parameters of the nucleus shape, namely, the sign and magnitude of nuclear deformation are derived from the mean energy proton scattering by a coupled channels method. The only direct way of deriving the nucleus surface deformation signs is the method of the Blaire phase shift. Results on scattering of electrons, protons, and α-particles on light and medium nuclei are reported. Data on the nucleus shape can be also obtained from reactions with heavy ions. A difference between strong absorptions of incident particles of high and average energy by a nucleus is noted. Numerous diagrams illustrate experimental and theoretical results

  19. Clusters in Nuclei. Vol. 2

    International Nuclear Information System (INIS)

    Beck, Christian

    2012-01-01

    Following the pioneering discovery of alpha clustering and of molecular resonances, the field of nuclear clustering is today one of those domains of heavy-ion nuclear physics that faces the greatest challenges, yet also contains the greatest opportunities. After many summer schools and workshops, in particular over the last decade, the community of nuclear molecular physicists has decided to collaborate in producing a comprehensive collection of lectures and tutorial reviews covering the field. This second volume follows the successful Lect. Notes Phys. 818 (Vol.1), and comprises six extensive lectures covering the following topics: - Microscopic cluster models - Neutron halo and break-up reactions - Break-up reaction models for two- and three-cluster projectiles - Clustering effects within the di-nuclear model - Nuclear alpha-particle condensates - Clusters in nuclei: experimental perspectives By promoting new ideas and developments while retaining a pedagogical style of presentation throughout, these lectures will serve as both a reference and an advanced teaching manual for future courses and schools in the fields of nuclear physics and nuclear astrophysics. (orig.)

  20. Clusters in Nuclei. Vol. 2

    Energy Technology Data Exchange (ETDEWEB)

    Beck, Christian (ed.) [Strasbourg Univ. (France). Inst. Pluridiciplinaire Hubert Curien

    2012-07-01

    Following the pioneering discovery of alpha clustering and of molecular resonances, the field of nuclear clustering is today one of those domains of heavy-ion nuclear physics that faces the greatest challenges, yet also contains the greatest opportunities. After many summer schools and workshops, in particular over the last decade, the community of nuclear molecular physicists has decided to collaborate in producing a comprehensive collection of lectures and tutorial reviews covering the field. This second volume follows the successful Lect. Notes Phys. 818 (Vol.1), and comprises six extensive lectures covering the following topics: - Microscopic cluster models - Neutron halo and break-up reactions - Break-up reaction models for two- and three-cluster projectiles - Clustering effects within the di-nuclear model - Nuclear alpha-particle condensates - Clusters in nuclei: experimental perspectives By promoting new ideas and developments while retaining a pedagogical style of presentation throughout, these lectures will serve as both a reference and an advanced teaching manual for future courses and schools in the fields of nuclear physics and nuclear astrophysics. (orig.)

  1. The morphology of cometary nuclei

    Science.gov (United States)

    Keller, H. U.; Jorda, L.

    comets display residual activity or clouds of dust grains around their nuclei. Taking the residual signal into account (mostly using simple models for the brightness distribution) the size estimates of the nuclei could be improved. The (nuclear) magnitude of a comet depends on the product of its albedo and cross-section. Only in a few cases could the albedo and size of a cometary nucleus be separated by additional observation of its thermal emission at infrared wavelengths. By comparison with outer Solar System asteroids Cruikshank et al. (1985) derived a surprisingly low albedo of about 0.04. A value in clear contradiction to the perception of an icy surface but fully confirmed by the first resolved images of a cometary nucleus during the flybys of the Vega and Giotto spacecraft of comet Halley (Sagdeev et al. 1986, Keller et al. 1986). The improvements of radar techniques led to the detection of reflected signals and finally to the derivation of nuclear dimensions and rotation rates. The observations, however, are also model dependent (rotation and size are similarly interwoven as are albedo and size) and sensitive to large dust grains in the vicinity of a nucleus. As an example, Kamoun et al. (1982) determined the radius of comet Encke to 1.5 (2.3, 1.0) km using the spin axis determination of Whipple and Sekanina (1979). The superb spatial resolution of the Hubble Space Telescope (HST) is not quite sufficient to resolve a cometary nucleus. The intensity distribution of the inner coma, however, can be observed and extrapolated toward the nucleus based on models of the dust distribution. If this contribution is subtracted from the central brightness the signal of the nucleus can be derived and hence its product of albedo times cross-section (Lamy and Toth 1995, Rembor 1998, Keller and Rembor 1998; Section 4.3). It has become clear that cometary nuclei are dark, small, often irregular bodies with dimensions ranging from about a kilometre (comet Wirtanen, the target of

  2. Male baldness.

    Science.gov (United States)

    Clarke, Philip

    2016-04-01

    Male baldness is very common. Its effect on individuals is extremely variable, and in some people it will have a significant adverse effect on their quality of life. The objectives of this article are to help general practitioners (GPs) be aware of potential health problems related to male baldness, to have an approach to assessing hair loss and to be aware of treatment options. Male baldness is, most often, a normal occurrence, but it may have significant effects on a man's health. It may also be a pointer to other potential health issues. The GP is in the ideal position to conduct an initial evaluation, consider other health issues and advise on treatment options.

  3. Understanding nuclei in the upper sd - shell

    Energy Technology Data Exchange (ETDEWEB)

    Sarkar, M. Saha; Bisoi, Abhijit; Ray, Sudatta [Nuclear Physics Division, Saha Institute of Nuclear Physics, Kolkata 700064 (India); Kshetri, Ritesh [Nuclear Physics Division, Saha Institute of Nuclear Physics, Kolkata 700064, India and Sidho-Kanho-Birsha University, Purulia - 723101 (India); Sarkar, S. [Indian Institute of Engineering Science and Technology, Shibpur, Howrah - 711103 (India)

    2014-08-14

    Nuclei in the upper-sd shell usually exhibit characteristics of spherical single particle excitations. In the recent years, employment of sophisticated techniques of gamma spectroscopy has led to observation of high spin states of several nuclei near A ≃ 40. In a few of them multiparticle, multihole rotational states coexist with states of single particle nature. We have studied a few nuclei in this mass region experimentally, using various campaigns of the Indian National Gamma Array setup. We have compared and combined our empirical observations with the large-scale shell model results to interpret the structure of these nuclei. Indication of population of states of large deformation has been found in our data. This gives us an opportunity to investigate the interplay of single particle and collective degrees of freedom in this mass region.

  4. Perspectives of production of superheavy nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Adamian, G. G.; Antonenko, N. V., E-mail: antonenk@theor.jinr.ru; Bezbakh, A. N.; Sargsyan, V. V. [Joint Institute for Nuclear Research, RU–141980 Dubna (Russian Federation); Scheid, W. [Institut für Theoretische Physik der Justus-Liebig-Universität, D–35392 Giessen (Germany)

    2016-07-07

    Possible ways of production of superheavies are discussed. Impact of nuclear structure on the production of superheavy nuclei in complete fusion reactions is discussed. The proton shell closure at Z = 120 is discussed.

  5. Nuclear Computational Low Energy Initiative (NUCLEI)

    Energy Technology Data Exchange (ETDEWEB)

    Reddy, Sanjay K. [University of Washington

    2017-08-14

    This is the final report for University of Washington for the NUCLEI SciDAC-3. The NUCLEI -project, as defined by the scope of work, will develop, implement and run codes for large-scale computations of many topics in low-energy nuclear physics. Physics to be studied include the properties of nuclei and nuclear decays, nuclear structure and reactions, and the properties of nuclear matter. The computational techniques to be used include Quantum Monte Carlo, Configuration Interaction, Coupled Cluster, and Density Functional methods. The research program will emphasize areas of high interest to current and possible future DOE nuclear physics facilities, including ATLAS and FRIB (nuclear structure and reactions, and nuclear astrophysics), TJNAF (neutron distributions in nuclei, few body systems, and electroweak processes), NIF (thermonuclear reactions), MAJORANA and FNPB (neutrino-less double-beta decay and physics beyond the Standard Model), and LANSCE (fission studies).

  6. Infrared Observations of Cometary Dust and Nuclei

    Science.gov (United States)

    Lisse, Carey

    2004-01-01

    This bibliography lists citations for publications published under the grant. Subjects of the publications include cometary dust, instellar and interplanetary dust, comet nuclei and comae, Comet Hale-Bopp, infrared observations of comets, mass loss, and comet break-up.

  7. Superheavy nuclei: a relativistic mean field outlook

    International Nuclear Information System (INIS)

    Afanasjev, A.V.

    2006-01-01

    The analysis of quasi-particle spectra in the heaviest A∼250 nuclei with spectroscopic data provides an additional constraint for the choice of effective interaction for the description of superheavy nuclei. It strongly suggests that only the parametrizations which predict Z = 120 and N = 172 as shell closures are reliable for superheavy nuclei within the relativistic mean field theory. The influence of the central depression in the density distribution of spherical superheavy nuclei on the shell structure is studied. A large central depression produces large shell gaps at Z = 120 and N = 172. The shell gaps at Z = 126 and N = 184 are favoured by a flat density distribution in the central part of the nucleus. It is shown that approximate particle number projection (PNP) by means of the Lipkin-Nogami (LN) method removes pairing collapse seen at these gaps in the calculations without PNP

  8. Searching for dual active galactic nuclei

    Indian Academy of Sciences (India)

    K. Rubinur

    2018-02-09

    Feb 9, 2018 ... Abstract. Binary or dual active galactic nuclei (DAGN) are expected from galaxy formation theories. How- ... cuss results from the multi-frequency Expanded Very .... mid-IR color using WISE observations where they have.

  9. Lipkin-Nogami method for rotating nuclei

    International Nuclear Information System (INIS)

    Magierski, P.

    1993-01-01

    The extension of Lipkin-Nogami method to the case of rotating nuclei, where the short-range attraction acting between the nucleus (pairing free) plays a significant role for the coupling scheme is discussed. 7 refs, 6 figs

  10. Collisions on relativistic nuclei: shock waves

    International Nuclear Information System (INIS)

    Gudima, K.K.; Toneev, V.D.

    1976-01-01

    Experiments are analysed which indicate the possible generation of shock waves in collisions of two nuclei. Another interpretation of these data is proposed and the concerned new experiments are discussed

  11. Non-equilibrium entropy in excited nuclei

    International Nuclear Information System (INIS)

    Betak, E.

    1991-06-01

    The time-dependent behaviour of entropy in excited nuclei is investigated. In distinction to recent claims, it is shown that no self-organization is involved in pre-equilibrium nuclear reactions. (author). 9 refs.; 4 figs

  12. ULTRA-RELATIVISTIC NUCLEI: A NEW FRONTIER

    International Nuclear Information System (INIS)

    MCLERRAN, L.

    1999-01-01

    The collisions of ultra-relativistic nuclei provide a window on the behavior of strong interactions at asymptotically high energies. They also will allow the authors to study the bulk properties of hadronic matter at very high densities

  13. High energy particle interactions with nuclei

    International Nuclear Information System (INIS)

    Czyz, W.

    1978-01-01

    The recent interest in multiparticle production processes on nuclei was triggered by re-discovering their 'enigmatic simplicity' which has been known to cosmic ray physicists for over 20 years: the mean multiplicity and angular distributions of relativistic secondaries produced on nuclei do not differ markedly from what emerges from p-p collisions. The author considers how such reactions may provide a way of obtaining details of hadron structure. (Auth.)

  14. Electro-magnetic properties of heavy nuclei

    International Nuclear Information System (INIS)

    Otsuka, Takaharu

    1989-01-01

    Two topics of electro-magnetic properties of heavy nuclei are discussed. The first topic is the M1 excitation from well-deformed heavy nuclei, and the other is the sudden increase of the isotope shift as a function of N in going away from the closed shell. These problems are considered in terms of the particle-number projected (Nilsson-) BCS calculation. (author)

  15. Hot nuclei, limiting temperatures and excitation energies

    International Nuclear Information System (INIS)

    Peter, J.

    1986-09-01

    Hot fusion nuclei are produced in heavy ion collisions at intermediate energies (20-100 MeV/U). Information on the maximum excitation energy per nucleon -and temperatures- indicated by the experimental data is compared to the predictions of static and dynamical calculations. Temperatures around 5-6 MeV are reached and seem to be the limit of formation of thermally equilibrated fusion nuclei

  16. Electron scattering and collective excitations in nuclei

    International Nuclear Information System (INIS)

    Goutte, D.

    1989-01-01

    Nuclear collective degrees of freedom are investigated through the study of the radial dependance of their wave function. Inelastic electron scattering is shown to be the appropriate tool to extract such a detailed information. Some recent results on spherical as well as deformed nuclei are discussed and the most recent extensions to the mean field approach are compared to these data in order to clarify the present status of our understanding of the dynamical properties of complex nuclei

  17. Proton radioactivity from proton-rich nuclei

    International Nuclear Information System (INIS)

    Guzman, F.; Goncalves, M.; Tavares, O.A.P.; Duarte, S.B.; Garcia, F.; Rodriguez, O.

    1999-03-01

    Half-lives for proton emission from proton-rich nuclei have been calculated by using the effective liquid drop model of heavy-particle decay of nuclei. It is shown that this model is able to offer results or spontaneous proton-emission half-life-values in excellent agreement with the existing experimental data. Predictions of half-life-values for other possible proton-emission cases are present for null orbital angular momentum. (author)

  18. Determining properties of baryon resonances in nuclei

    International Nuclear Information System (INIS)

    Johnson, M.B.; Chen, C.M.; Ernst, D.J.; Jiang, M.F.

    1996-01-01

    Meson-nucleus and photon-nucleus interactions are important sources of information about the medium modifications of baryon resonances in nuclei. Indications of how large the medium effects are for resonances above the Δ 33 (1232) are provided by it combined analysis of photonuclear and pion cross sections in the GeV range of energies. Tile existing data indicate a possible 10-20% renormalization of the pion coupling to higher-lying resonances in nuclei

  19. Nuclei far off the stability line

    International Nuclear Information System (INIS)

    Fenyes, T.

    1978-01-01

    Theoretical and experimental aspects of the formation of some ''exotic'' nuclei far off the stability line were reviewed in addition to the relevant results of research in this field. Results in beta- and gamma-ray spectroscopy, heavy-ion-spectroscopy, achievements in the fields of measuring the atomic mass, the moment, and the radius of the nuclei as well as some astronomical aspects were described. (Z.P.)

  20. Thomas Fermi model of finite nuclei

    International Nuclear Information System (INIS)

    Boguta, J.; Rafelski, J.

    1977-01-01

    A relativistic Thomas-Fermi model of finite-nuclei is considered. The effective nuclear interaction is mediated by exchanges of isoscalar scalar and vector mesons. The authors include also a self-interaction of the scalar meson field and the Coulomb repulsion of the protons. The parameters of the model are constrained by the average nuclear properties. The Thomas-Fermi equations are solved numerically for finite, stable nuclei. The particular case of 208 82 Pb is considered in more detail. (Auth.)

  1. Structure of neutron-rich nuclei

    International Nuclear Information System (INIS)

    Nazarewicz, W.

    2000-01-01

    Complete text of publication follows. The uncharted regions of the (N,Z) plane contain information that can answer many questions of fundamental importance for science: How many protons and neutrons can be clustered together by the strong interaction to form a bound nucleus? What are the proton and neutron magic numbers of the exotic nuclei? What are the properties of very short-lived exotic nuclei with extreme neutron-to-proton ratios? What is the effective nucleon-nucleon interaction in a nucleus that has a very large neutron excess? Nuclear life far from stability is different from that around the stability line; the promised access to completely new combinations of proton and neutron numbers offers prospects for new structural phenomena. The main objective of this talk is to discuss some of the challenges and opportunities of research with exotic nuclei. The covered topics will include: Theoretical challenges; Skins and halos in heavy nuclei; Shape coexistence in exotic nuclei; Beta-decays of neutron-rich nuclei. (author)

  2. Major new sources of biological ice nuclei

    Science.gov (United States)

    Moffett, B. F.; Hill, T.; Henderson-Begg, S. K.

    2009-12-01

    Almost all research on biological ice nucleation has focussed on a limited number of bacteria. Here we characterise several major new sources of biogenic ice nuclei. These include mosses, hornworts, liverworts and cyanobacteria. Ice nucleation in the eukaryotic bryophytes appears to be ubiquitous. The temperature at which these organisms nucleate is that at which the difference in vapour pressure over ice and water is at or close to its maximum. At these temperatures (-8 to -18 degrees C) ice will grow at the expense of supercooled water. These organisms are dependent for their water on occult precipitation - fog, dew and cloudwater which by its nature is not collected in conventional rain gauges. Therefore we suggest that these organism produce ice nuclei as a water harvesting mechanism. Since the same mechanism would also drive the Bergeron-Findeisen process, and as moss is known to become airborne, these nuclei may have a role in the initiation of precipitation. The properties of these ice nuclei are very different from the well characterised bacterial nuclei. We will also present DNA sequence data showing that, although related, the proteins responsible are only very distantly related to the classical bacterial ice nuclei.

  3. Correlation of Hypoxia and Pro-senescence Protein Expression in Green Sea Turtle (Chelonia mydas Lung Epithelial and Dermal Fibroblast Cell Culture

    Directory of Open Access Journals (Sweden)

    Anggraini Barlian

    2018-03-01

    Full Text Available Recent studies have shown hypoxia-induced gene expression correlated with cellular senescence. HIF-1α (hypoxia-inducible factor 1-alpha, p53, and pRB were induced under hypoxia and correlated with cellular senescence. The localization and expression of HIF-1α, p53, and pRB in Chelonia mydas lung epithelial and dermal fibroblast cell cultures were analyzed under normoxic and hypoxic conditions (at 4 and 24 hours. Human dermal fibroblast was used for comparison purposes. Protein localization was analyzed with immunocytochemistry, while protein expression was analyzed with the Western blot and enhanced chemiluminescence (ECL method. HIF-1α, p53, and pRB were localized in the nuclei of the C. mydas cell cultures treated with hypoxia. The C. mydas lung epithelial cell cultures had a higher increase of HIF-1α expression than the human dermal fibroblast cell culture. The hypoxic conditions did not affect p53 expression significantly in C. mydas lung epithelial and dermal fibroblast cell cultures. Meanwhile, pRB expression changed significantly under hypoxia in the C. mydas dermal fibroblast cells. Expression of p53 and pRB in the human cell cultures was higher than in the C. mydas cell cultures. This research suggests that C. mydas and human cell cultures have different pro-senescence protein expression responses under hypoxic conditions.

  4. The effect of tranilast on fibroblast activation protein α (FAP-α expression in normal and keloid fibroblasts in vitro

    Directory of Open Access Journals (Sweden)

    Paweł P. Antończak

    2017-07-01

    Full Text Available Introduction . Tranilast (N-(3’,4’-demethoxycinnamoyl-anthranilic acid is an anti-allergic drug. Its mechanism of action is based on the inhibition of antigen-induced release of chemical mediators from mast cells and basophils. It also reveals antifibroproliferative activities. These properties of tranilast are used in the treatment of hypertrophic scars and keloids. Keloids are characterized by incorrect extracellular matrix components turnover. Fibroblasts derived from keloids reveal overproduction of collagen type I and decreased degradation of extracellular matrix in comparison with normal fibroblasts. Fibroblast activation protein α (FAP-α may play an important role in remodeling of extracellular matrix and the invasive properties of keloids. Objective . In the present study, the effect of tranilast on expression of FAP-α gene and its protein was evaluated in normal human dermal fibroblasts and fibroblasts derived from keloids cultured in vitro . Materials and methods. In the first stage of the study, the influence of tranilast on cell viability was estimated. The second stage of the study included the quantitative evaluation of FAP-α mRNA expression in normal and keloid fibroblasts treated with tranilast. The third stage of the study comprised fibroblast activation protein α expression analysis in the examined cells treated with tranilast. Results and conclusions . The expression of FAP-α gene and fibroblast activation protein α is higher in keloid fibroblasts. Tranilast at concentrations of 3 μM and 30 μM up-regulated mRNA FAP-α expression in normal fibroblasts but did not influence keloid fibroblasts. The drug, at concentrations of 30 μM and 300 μM up-regulated fibroblast activation protein α expression in normal fibroblasts and did not influence keloid fibroblasts. Tranilast antiproliferative effect is not associated with FAP-α expression in keloid fibroblasts.

  5. DNA damage in male gonad cells of Green mussel (Perna viridis) upon exposure to tobacco products

    Digital Repository Service at National Institute of Oceanography (India)

    Nagarajappa; Ganguly, A.; Goswami, U.

    DNA damage (determined by the Comet Assay) and the occurrence of deformed nuclei were measured as endpoints of genotoxicity in male gonad cells of the marine mussel (Perna viridis). Upon exposure of the organism to varying concentrations...

  6. Oral fibroblasts produce more HGF and KGF than skin fibroblasts in response to co-culture with keratinocytes

    DEFF Research Database (Denmark)

    Grøn, Birgitte; Stoltze, Kaj; Andersson, Anders

    2002-01-01

    The production of hepatocyte growth factor (HGF) and keratinocyte growth factor (KGF) in subepithelial fibroblasts from buccal mucosa, periodontal ligament, and skin was determined after co-culture with keratinocytes. The purpose was to detect differences between the fibroblast subpopulations...... days by ELISA. When cultured on polystyrene, the constitutive level of KGF and HGF in periodontal fibroblasts was higher than the level in buccal and skin fibroblasts. In the presence of keratinocytes, all three types of fibroblasts in general increased their HGF and KGF production 2-3 times. When...... cells were maintained in collagen, the level of HGF and KGF was decreased mainly in skin cultures. However, in oral fibroblasts, induction after stimulation was at a similar level in collagen compared to on polystyrene. Skin fibroblasts maintained in collagen produced almost no HGF whether...

  7. Lung Fibroblasts, Aging, and Idiopathic Pulmonary Fibrosis.

    Science.gov (United States)

    Pardo, Annie; Selman, Moisés

    2016-12-01

    Idiopathic pulmonary fibrosis (IPF) is an aging-associated, progressive, and irreversible lung disease of unknown etiology, elusive pathogenesis, and very limited therapeutic options. The hallmarks of IPF are aberrant activation of alveolar epithelial cells and accumulation of fibroblasts and myofibroblasts along with excessive production of extracellular matrix. The linkage of aging with this disorder is uncertain, but a number of changes associated with aging, including telomere attrition, cell senescence, and mitochondrial dysfunction, have been revealed in IPF lungs. Also, aging seems to confer a profibrotic phenotype upon fibroblasts and to increase the severity of the fibrogenic response in non-IPF fibrotic lung disorders. Better knowledge of the pathophysiological mechanisms linking aging to IPF will advance understanding of its pathogenesis and may provide new therapeutic windows to treatment of this devastating disease.

  8. Diffraction scattering and disintegration of 3He nuclei by atomic nuclei

    International Nuclear Information System (INIS)

    Koval'chuk, V.I.

    2006-01-01

    Within diffraction model framework a method of cross sections calculation for scattering and disintegration of weakly-bounded two-clustered nuclei by nuclei when both of its clusters are changed has been proposed. The experimental elastic scattering cross sections of 3 He by 40 Ca, 90 Zr and coincidence spectra of disintegration products from 28 Si( 3 He,dp) have been described

  9. Stability and production of superheavy nuclei

    International Nuclear Information System (INIS)

    Moeller, P.; Los Alamos National Lab., NM; Nix, J.R.

    1997-01-01

    Beyond uranium heavy elements rapidly become increasingly unstable with respect to spontaneous fission as the proton number Z increases, because of the disruptive effect of the long-range Coulomb force. However, in the region just beyond Z = 100 magic proton and neutron numbers and the associated shell structure enhances nuclear stability sufficient to allow observation of additional nuclei. Some thirty years ago it was speculated that an island of spherical, relatively stable superheavy nuclei would exist near the next doubly magic proton-neutron combination beyond 208 Pb, that is, at proton number Z 114 and neutron number N = 184. Theory and experiment now show that there also exists a rock of stability in the vicinity of Z = 110 and N = 162 between the actinide region, which previously was the end of the peninsula of known elements, and the predicted island of spherical superheavy nuclei slightly southwest of the magic numbers Z = 114 and N = 184. The authors review here the stability properties of the heavy region of nuclei. Just as the decay properties of nuclei in the heavy region depend strongly on shell structure, this structure also dramatically affects the fusion entrance channel. The six most recently discovered new elements were all formed in cold-fusion reactions. They discuss here the effect of the doubly magic structure of the target in cold-fusion reactions on the fusion barrier and on dissipation

  10. Electron scattering and reactions from exotic nuclei

    International Nuclear Information System (INIS)

    Karataglidis, S.

    2017-01-01

    The SCRIT and FAIR/ELISe experiments are the first to attempt to measure directly electron scattering form factors from nuclei far from stability. This will give direct information for the (one-body) charge densities of those systems, about which there is little information available. The SCRIT experiment will be taking data for medium-mass exotic nuclei, while the electron-ion collider at ELISe, when constructed, will be able to measure form factors for a wide range of exotic nuclei, as available from the radioactive ion beams produced by the FAIR experiment. Other facilities are now being proposed, which will also consider electron scattering from exotic nuclei at higher energies, to study short-range correlations in exclusive reactions. This review will consider all available information concerning the current status (largely theoretical) of electron scattering from exotic nuclei and, where possible, complement such information with equivalent information concerning the neutron densities of those exotic systems, as obtained from intermediate energy proton scattering. The issue of long- and short-range correlations will be discussed, and whether extending such studies to the exotic sector will elicit new information. (orig.)

  11. Relativistic mean field theory for unstable nuclei

    International Nuclear Information System (INIS)

    Toki, Hiroshi

    2000-01-01

    We discuss the properties of unstable nuclei in the framework of the relativistic mean field (RMF) theory. We take the RMF theory as a phenomenological theory with several parameters, whose form is constrained by the successful microscopic theory (RBHF), and whose values are extracted from the experimental values of unstable nuclei. We find the outcome with the newly obtained parameter sets (TM1 and TMA) is promising in comparison with various experimental data. We calculate systematically the ground state properties of even-even nuclei up to the drip lines; about 2000 nuclei. We find that the neutron magic shells (N=82, 128) at the standard magic numbers stay at the same numbers even far from the stability line and hence provide the feature of the r-process nuclei. However, many proton magic numbers disappear at the neutron numbers far away from the magic numbers due to the deformations. We discuss how to describe giant resonances for the case of the non-linear coupling terms for the sigma and omega mesons in the relativistic RPA. We mention also the importance of the relativistic effect on the spin observables as the Gamow-Teller strength and the longitudinal and transverse spin responses. (author)

  12. Flavanol binding of nuclei from tree species.

    Science.gov (United States)

    Feucht, W; Treutter, D; Polster, J

    2004-01-01

    Light microscopy was used to examine the nuclei of five tree species with respect to the presence of flavanols. Flavanols develop a blue colouration in the presence of a special p-dimethylaminocinnamaldehyde (DMACA) reagent that enables those nuclei loaded with flavanols to be recognized. Staining of the nuclei was most pronounced in both Tsuga canadensis and Taxus baccata, variable in Metasequoia glyptostroboides, faint in Coffea arabica and minimal in Prunus avium. HPLC analysis showed that the five species contained substantial amounts of different flavanols such as catechin, epicatechin and proanthocyanidins. Quantitatively, total flavanols were quite different among the species. The nuclei themselves, as studied in Tsuga seed wings, were found to contain mainly catechin, much lower amounts of epicatechin and traces of proanthocyanidins. Blue-coloured nuclei located centrally in small cells were often found to maximally occupy up to 90% of a cell's radius, and the surrounding small rim of cytoplasm was visibly free of flavanols. A survey of 34 gymnosperm and angiosperm species indicated that the first group has much higher nuclear binding capacities for flavanols than the second group.

  13. Chaos in nuclei: Theory and experiment

    Science.gov (United States)

    Muñoz, L.; Molina, R. A.; Gómez, J. M. G.

    2018-05-01

    During the last three decades the quest for chaos in nuclei has been quite intensive, both with theoretical calculations using nuclear models and with detailed analyses of experimental data. In this paper we outline the concept and characteristics of quantum chaos in two different approaches, the random matrix theory fluctuations and the time series fluctuations. Then we discuss the theoretical and experimental evidence of chaos in nuclei. Theoretical calculations, especially shell-model calculations, have shown a strongly chaotic behavior of bound states in regions of high level density. The analysis of experimental data has shown a strongly chaotic behavior of nuclear resonances just above the one-nucleon emission threshold. For bound states, combining experimental data of a large number of nuclei, a tendency towards chaotic motion is observed in spherical nuclei, while deformed nuclei exhibit a more regular behavior associated to the collective motion. On the other hand, it had never been possible to observe chaos in the experimental bound energy levels of any single nucleus. However, the complete experimental spectrum of the first 151 states up to excitation energies of 6.20 MeV in the 208Pb nucleus have been recently identified and the analysis of its spectral fluctuations clearly shows the existence of chaotic motion.

  14. Training nuclei detection algorithms with simple annotations

    Directory of Open Access Journals (Sweden)

    Henning Kost

    2017-01-01

    Full Text Available Background: Generating good training datasets is essential for machine learning-based nuclei detection methods. However, creating exhaustive nuclei contour annotations, to derive optimal training data from, is often infeasible. Methods: We compared different approaches for training nuclei detection methods solely based on nucleus center markers. Such markers contain less accurate information, especially with regard to nuclear boundaries, but can be produced much easier and in greater quantities. The approaches use different automated sample extraction methods to derive image positions and class labels from nucleus center markers. In addition, the approaches use different automated sample selection methods to improve the detection quality of the classification algorithm and reduce the run time of the training process. We evaluated the approaches based on a previously published generic nuclei detection algorithm and a set of Ki-67-stained breast cancer images. Results: A Voronoi tessellation-based sample extraction method produced the best performing training sets. However, subsampling of the extracted training samples was crucial. Even simple class balancing improved the detection quality considerably. The incorporation of active learning led to a further increase in detection quality. Conclusions: With appropriate sample extraction and selection methods, nuclei detection algorithms trained on the basis of simple center marker annotations can produce comparable quality to algorithms trained on conventionally created training sets.

  15. Electron scattering and reactions from exotic nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Karataglidis, S. [University of Johannesburg, Department of Physics, Auckland Park (South Africa); University of Melbourne, School of Physics, Victoria (Australia)

    2017-04-15

    The SCRIT and FAIR/ELISe experiments are the first to attempt to measure directly electron scattering form factors from nuclei far from stability. This will give direct information for the (one-body) charge densities of those systems, about which there is little information available. The SCRIT experiment will be taking data for medium-mass exotic nuclei, while the electron-ion collider at ELISe, when constructed, will be able to measure form factors for a wide range of exotic nuclei, as available from the radioactive ion beams produced by the FAIR experiment. Other facilities are now being proposed, which will also consider electron scattering from exotic nuclei at higher energies, to study short-range correlations in exclusive reactions. This review will consider all available information concerning the current status (largely theoretical) of electron scattering from exotic nuclei and, where possible, complement such information with equivalent information concerning the neutron densities of those exotic systems, as obtained from intermediate energy proton scattering. The issue of long- and short-range correlations will be discussed, and whether extending such studies to the exotic sector will elicit new information. (orig.)

  16. Fundamental Physics with Electroweak Probes of Nuclei

    Science.gov (United States)

    Pastore, Saori

    2018-02-01

    The past decade has witnessed tremendous progress in the theoretical and computational tools that produce our understanding of nuclei. A number of microscopic calculations of nuclear electroweak structure and reactions have successfully explained the available experimental data, yielding a complex picture of the way nuclei interact with electroweak probes. This achievement is of great interest from the pure nuclear-physics point of view. But it is of much broader interest too, because the level of accuracy and confidence reached by these calculations opens up the concrete possibility of using nuclei to address open questions in other sub-fields of physics, such as, understanding the fundamental properties of neutrinos, or the particle nature of dark matter. In this talk, I will review recent progress in microscopic calculations of electroweak properties of light nuclei, including electromagnetic moments, form factors and transitions in between lowlying nuclear states along with preliminary studies for single- and double-beta decay rates. I will illustrate the key dynamical features required to explain the available experimental data, and, if time permits, present a novel framework to calculate neutrino-nucleus cross sections for A > 12 nuclei.

  17. 25-Hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-κB dependent pathway

    Energy Technology Data Exchange (ETDEWEB)

    Ichikawa, Tomohiro [Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, 811-1 Kimiidera, Wakayama 641-8509 (Japan); Sugiura, Hisatoshi, E-mail: sugiura@rm.med.tohoku.ac.jp [Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574 (Japan); Koarai, Akira; Kikuchi, Takashi; Hiramatsu, Masataka; Kawabata, Hiroki; Akamatsu, Keiichiro; Hirano, Tsunahiko; Nakanishi, Masanori; Matsunaga, Kazuto; Minakata, Yoshiaki [Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, 811-1 Kimiidera, Wakayama 641-8509 (Japan); Ichinose, Masakazu [Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574 (Japan)

    2013-05-01

    Abnormal structural alterations termed remodeling, including fibrosis and alveolar wall destruction, are important features of the pathophysiology of chronic airway diseases such as chronic obstructive pulmonary disease (COPD) and asthma. 25-hydroxycholesterol (25-HC) is enzymatically produced by cholesterol 25-hydorxylase (CH25H) in macrophages and is reported to be involved in the formation of arteriosclerosis. We previously demonstrated that the expression of CH25H and production of 25HC were increased in the lungs of COPD. However, the role of 25-HC in lung tissue remodeling is unknown. In this study, we investigated the effect of 25-HC on fibroblast-mediated tissue remodeling using human fetal lung fibroblasts (HFL-1) in vitro. 25-HC significantly augmented α-smooth muscle actin (SMA) (P<0.001) and collagen I (P<0.001) expression in HFL-1. 25-HC also significantly enhanced the release and activation of matrix metallaoproteinase (MMP)-2 (P<0.001) and MMP-9 (P<0.001) without any significant effect on the production of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2. 25-HC stimulated transforming growth factor (TGF)-β{sub 1} production (P<0.01) and a neutralizing anti-TGF-β antibody restored these 25-HC-augmented pro-fibrotic responses. 25-HC significantly promoted the translocation of nuclear factor (NF)-κB p65 into the nuclei (P<0.01), but not phospholylated-c-jun, a complex of activator protein-1. Pharmacological inhibition of NF-κB restored the 25-HC-augmented pro-fibrotic responses and TGF-β{sub 1} release. These results suggest that 25-HC could contribute to fibroblast-mediated lung tissue remodeling by promoting myofibroblast differentiation and the excessive release of extracellular matrix protein and MMPs via an NF-κB-TGF-β dependent pathway.

  18. Production and de excitation of hot nuclei

    International Nuclear Information System (INIS)

    Auger, F.; Faure, B.; Wirleczki, J.P.; Cunsolo, A.; Foti, A.; Plagnol, E.

    1988-01-01

    We studied Kr induced reactions on C, Al and Ti at 26.4, 34.4 and 45.4 MeV/nucleon. The aims of these experiments were to learn about the influence of the incident energy and asymmetry of the system on the incomplete fusion mechanism, that is on the characteristics (E,l) of the nuclei formed in the reactions and on the competition between massive transfer and preequilibrium emission. We also wanted to study the influence of excitation energy and angular momentum of the nuclei on their deexcitation modes, specially on the competition between light particles (n, p, α) and complex fragments (M>4). Considering the available energies (2.8 < ε < 10.5 MeV/nucleon), the grazing and the total masses (96 ≤ M ≤ 132), nuclei with masses around 100 are likely to be formed with very different excitation energies and angular momenta

  19. Critical and shape-unstable nuclei

    CERN Document Server

    Cailliau, M; Husson, J P; Letessier, J; Mang, H J

    1973-01-01

    The authors' experimental work on the decay of neutron deficient mercury osmium nuclei, some other studies at ISOLDE (CERN) and their first theoretical analysis show that the nuclei around /sup 186/Pt (Z=78, N=108) are at the limit of spherical, oblate, prolate nuclei, have (the even one) their first 0/sup +/ excited states at very low energy; quasi- rotational bands are associated to these states. The energy of this O/sup +/ state in /sup 186-/Pt deviate from the Kumar value: angular shape instability is not enough to explain this result. The authors look at radial shape and pairing fluctuations. The position of the 4p-4n state must also be known. (0 refs).

  20. Reflections on cavitation nuclei in water

    DEFF Research Database (Denmark)

    Mørch, Knud Aage

    2007-01-01

    to explaining why the tensile strength of water varies so dramatically between the experiments reported. A model for calculation of the critical pressure of skin-covered free gas bubbles as well as that of interfacial gaseous nuclei covered by a skin is presented. This model is able to bridge the apparently......The origin of cavitation bubbles, cavitation nuclei, has been a subject of debate since the early years of cavitation research. This paper presents an analysis of a representative selection of experimental investigations of cavitation inception and the tensile strength of water. At atmospheric...... pressure, the possibility of stabilization of free gas bubbles by a skin has been documented, but only within a range of bubble sizes that makes them responsible for tensile strengths up to about 1.5 bar, and values reaching almost 300 bar have been measured. However, cavitation nuclei can also be harbored...

  1. Accretion disks in active galactic nuclei

    International Nuclear Information System (INIS)

    Shields, G.A.

    1989-01-01

    Active galactic nuclei (AGN) have taunted astrophysicists for a quarter century. How do these objects produce huge luminosities---in some cases, far outshining our galaxy---from a region perhaps no larger than the solar system? Accretion onto supermassive black holes has been widely considered the best buy in theories of AGN. Much work has gone into accretion disk theory, searches for black holes in galactic nuclei, and observational tests. These efforts have not proved the disk model, but there is progress. Evidence for black holes in the nuclei of nearby galaxies is provided by observations of stellar velocities, and radiation from the disk's hot surface may be observed in the ultraviolet (UV) and neighboring spectral bands. In the review, the author describe some of the recent work on accretion disks in AGN, with an emphasis on points of contact between theory and observation

  2. Search for supermassive nuclei in nature

    International Nuclear Information System (INIS)

    Polikanov, S.; Sastri, C.S.; Herrmann, G.; Luetzenkirchen, K.; Overbeck, M.; Trautmann, N.

    1990-11-01

    We report on a search for supermassive nuclei in nature with masses up to 10 7 amu. Such exotic nuclei might consist, for example, of stable strange matter, which comprises a mixture of up, down, and strange quarks, or of relic particles from the early Universe. The experiments are based on Rutherford backscattering of heavy ions, preferably 238 U, from various target samples. The measured parameters of a deteced particle are its time-of-flight, scattering angle, and specific ionization. From this information the mass of the target nucleus can be inferred. Upper limits for the abundance of strange supermassive nuclei with masses A ≅ 4x10 2 to 10 7 amu relative to the number of nucleons were found to be in the range 10 -11 to 10 -15 . For the narrower mass range A ≅ 10 3 to 10 4 amu the limit is 2x10 -17 . (orig.)

  3. Effects of tensor forces in nuclei

    International Nuclear Information System (INIS)

    Tanihata, Isao

    2013-01-01

    Recent studies of nuclei far from the stability line have revealed drastic changes in nuclear orbitals and reported the appearance of new magic numbers and the disappearance of magic numbers observed at the stability line. One of the important reasons for such changes is considered to be because of the effect of tensor forces on nuclear structure. Although the role of tensor forces in binding very light nuclei such as deuterons and 4 He has been known, direct experimental evidence for the effect on nuclear structure is scarce. In this paper, I review known effects of tensor forces in nuclei and then discuss the recently raised question of s–p wave mixing in a halo nucleus of 11 Li. Following these reviews, the development of a new experiment to see the high-momentum components due to the tensor forces is discussed and some of the new data are presented. (paper)

  4. Effective forces in near-magic nuclei

    International Nuclear Information System (INIS)

    Artamonov, S.A.; Isakov, V.I.; Ogloblin, S.G.

    1984-01-01

    Characteristics of 146 Gd, 206 Hg, sup(206, 208)Tl, sup(206, 208, 210)Pb, sup(208, 210)Bi, 210 Po nuclei are calculated on the base of representations on universal effective interaction of finite range. Discrepancy with the experiment for 210 Bi nucleus disappears if the method of ''penalty'' functions is used for search of optimum parameters. New parameters of effective interaction common for all the considered two-quasi-particle nuclei are determined. Parameters of tensor forces undergo most noticeable danges as compared with other calculations. Descriptions of lowest levels not only 210 Bi but also 206 Tl as well as collective states of 208 Pb and a new magic nucleus 146 Gd are improved. The calculated probabilities of electric transitions between ground and one-phonon states in core nuclei also agree with the experiment

  5. Chromosome aberration induction in human diploid fibroblast and epithelial cells

    International Nuclear Information System (INIS)

    Scott, D.

    1986-01-01

    The relative sensitivity of cultured human fibroblasts and epithelial cells to radiation-induced chromosomal aberrations was investigated. Lung fibroblast and kidney epithelial cells from the same fetus were compared, as were skin fibroblasts and epithelial keratinocytes from the same foreskin sample. After exposure of proliferating fetal cells to 1.5 Gy X-rays there was a very similar aberration yield in the fibroblasts and epithelial cells. Observations of either little or no difference in chromosomal sensitivity between human fibroblasts and epithelial cells give added confidence that quantitative cytogenetic data obtained from cultured fibroblasts are relevant to the question of sensitivity of epithelial cells which are the predominant cell type in human cancers. (author)

  6. Particle-rotation coupling in atomic nuclei

    International Nuclear Information System (INIS)

    Almberger, J.

    1980-01-01

    Recently an increased interest in the rotational nuclei has been spurred by the new experimental high-spin activities and by the possibilities for lower spins to interpret an impressive amount of experimental data by some comparatively simple model calculations. The author discusses the particle modes of excitation for rotational nuclei in the pairing regime where some puzzles in the theoretical description remain to be resolved. A model comparison is made between the particle-rotor and cranking models which have different definitions of the collective rotation. The cranking model is found to imply a smaller value of the quasiparticle spin alignment than the particle-rotor model. Rotational spectra for both even and odd nuclei are investigated with the use of the many-BCS-quasiparticles plus rotor model. This model gives an accurate description of the ground and S-bands in many even-even rare-earth nuclei. However, the discrepancies for odd-A nuclei between theory and experiments point to the importance of additional physical components. Therefore the rotationally induced quadrupole pair field is considered. This field has an effect on the low spin states in odd-A nuclei, but is not sufficient to account for the experimental data. Another topic considered is the interaction matrix element in crossings for given spin between quasiparticle rotational bands. The matrix elements are found to oscillate as a function of the number of particles, thereby influencing the sharpness of the backbending. Finally the low-spin continuation of the S-band is studied and it is shown that such states can be populated selectively by means of one-particle pickup reactions involving high angular momentum transfer. (Auth.)

  7. Modeling the phenotype of spinal muscular atrophy by the direct conversion of human fibroblasts to motor neurons.

    Science.gov (United States)

    Zhang, Qi-Jie; Li, Jin-Jing; Lin, Xiang; Lu, Ying-Qian; Guo, Xin-Xin; Dong, En-Lin; Zhao, Miao; He, Jin; Wang, Ning; Chen, Wan-Jin

    2017-02-14

    Spinal muscular atrophy (SMA) is a lethal autosomal recessive neurological disease characterized by selective degeneration of motor neurons in the spinal cord. In recent years, the development of cellular reprogramming technology has provided an alternative and effective method for obtaining patient-specific neurons in vitro. In the present study, we applied this technology to the field of SMA to acquire patient-specific induced motor neurons that were directly converted from fibroblasts via the forced expression of 8 defined transcription factors. The infected fibroblasts began to grow in a dipolar manner, and the nuclei gradually enlarged. Typical Tuj1-positive neurons were generated at day 23. After day 35, induced neurons with multiple neurites were observed, and these neurons also expressed the hallmarks of Tuj1, HB9, ISL1 and CHAT. The conversion efficiencies were approximately 5.8% and 5.5% in the SMA and control groups, respectively. Additionally, the SMA-induced neurons exhibited a significantly reduced neurite outgrowth rate compared with the control neurons. After day 60, the SMA-induced neurons also exhibited a liability of neuronal degeneration and remarkable fracturing of the neurites was observed. By directly reprogramming fibroblasts, we established a feeder-free conversion system to acquire SMA patient-specific induced motor neurons that partially modeled the phenotype of SMA in vitro.

  8. Symmetry structure in neutron deficient xenon nuclei

    International Nuclear Information System (INIS)

    Govil, I. M.

    1998-01-01

    The paper describes the measurements of the lifetimes of the excited states in the ground state band of the Neutron deficient Xe nuclei ( 122,124 Xe) by recoil Distance Method (RDM). The lifetimes of the 2 + state in 122 Xe agrees with the RDM measurements but for 124 Xe it does not agree the RDM measurements but agrees with the earlier Coulomb-excitation experiment. The experimental results are compared with the existing theories to understand the changes in the symmetry structure of the Xe-nuclei as the Neutron number decreases from N=76( 130 Xe) to N=64( 118 Xe)

  9. Symmetry structure in neutron deficient xenon nuclei

    Science.gov (United States)

    Govil, I. M.

    1998-12-01

    The paper describes the measurements of the lifetimes of the excited states in the ground state band of the Neutron deficient Xe nuclei (122,124Xe) by recoil Distance Method (RDM). The lifetimes of the 2+ state in 122Xe agrees with the RDM measurements but for 124Xe it does not agree the RDM measurements but agrees with the earlier Coulomb-excitation experiment. The experimental results are compared with the existing theories to understand the changes in the symmetry structure of the Xe-nuclei as the Neutron number decreases from N=76(130Xe) to N=64(118Xe).

  10. MAGIC NUCLEI: Tin-100 turns up

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    In the same way as the Periodic Table of chemical elements reflects the successive filling of orbital electron shells, in nuclear physics the socalled 'magic' numbers correspond to closed shells of 2, 8, 20, 28, 50, 82, 126,... neutrons and/or protons. More tightly bound than other nuclei, these are the nuclear analogues of the inert gases. 'Doubly magic' nuclei have closed shells of both neutrons and protons. Examples in nature are helium-4 (2 protons and 2 neutrons), oxygen-16 (8 and 8), calcium-40 (20 and 20) and calcium-48 (20 and 28). Radioactive tin-132 (50+82) has been widely studied

  11. Virtual photon spectra for finite nuclei

    International Nuclear Information System (INIS)

    Wolynec, E.; Martins, M.N.

    1988-01-01

    The experimental results of an isochromat of the virtual photon spectrum, obtained by measuring the number of ground-state protons emitted by the 16.28 MeV isobaric analogue state in 90 Zr as a function of electron incident energy in the range 17-105 MeV, are compared with the values predicted by a calculation of the E1 DWBA virtual photon spectra for finite nuclei. It is found that the calculations are in excellent agreement with the experimental results. The DWBA virtual photon spectra for finite nuclei for E2 and M1 multipoles are also assessed. (author) [pt

  12. Dynamical symmetries for odd-odd nuclei

    International Nuclear Information System (INIS)

    Balantekin, A.B.

    1986-01-01

    Recent work for developing dynamical symmetries and supersymmetries is reviewed. An accurate description of odd-odd nuclei requires inclusion of the fermion-fermion force (the residual interaction) and the distinguishing of fermion configurations which are particle like and those which are hole like. A parabolic dependence of the proton-neutron multiplet in odd-odd nuclei is demonstrated. It is shown that a group structure for Bose-Fermi symmetries can be embedded in a supergroup. These methods are used to predict level schemes for Au-196 and Au-198. 11 refs., 3 figs

  13. Medium energy hadron scattering from nuclei

    International Nuclear Information System (INIS)

    Ginocchio, J.N.; Wenes, G.

    1986-01-01

    The Glauber approximation for medium energy scattering of hadronic projectiles from nuclei is combined with the interacting boson model of nuclei to produce a transition matrix for elastic and inelastic scattering in algebraic form which includes coupling to all the intermediate states. We present closed form analytic expresions for the transition matrix elements for the three dynamical symmetries of the interacting boson model; that is for, a spherical quadrupole vibrator, a γ unstable rotor, and both prolate and oblate axially symmetric rotors. We give examples of application of this formalism to proton scattering from 154 Sm and 154 Gd. 27 refs., 5 figs., 1 tab

  14. Monte Carlo approaches to light nuclei

    International Nuclear Information System (INIS)

    Carlson, J.

    1990-01-01

    Significant progress has been made recently in the application of Monte Carlo methods to the study of light nuclei. We review new Green's function Monte Carlo results for the alpha particle, Variational Monte Carlo studies of 16 O, and methods for low-energy scattering and transitions. Through these calculations, a coherent picture of the structure and electromagnetic properties of light nuclei has arisen. In particular, we examine the effect of the three-nucleon interaction and the importance of exchange currents in a variety of experimentally measured properties, including form factors and capture cross sections. 29 refs., 7 figs

  15. Monte Carlo approaches to light nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Carlson, J.

    1990-01-01

    Significant progress has been made recently in the application of Monte Carlo methods to the study of light nuclei. We review new Green's function Monte Carlo results for the alpha particle, Variational Monte Carlo studies of {sup 16}O, and methods for low-energy scattering and transitions. Through these calculations, a coherent picture of the structure and electromagnetic properties of light nuclei has arisen. In particular, we examine the effect of the three-nucleon interaction and the importance of exchange currents in a variety of experimentally measured properties, including form factors and capture cross sections. 29 refs., 7 figs.

  16. Measurement of recoil nuclei of Ta photofission

    International Nuclear Information System (INIS)

    Amroyan, K.A.; Barsegyan, S.A.; Demekhina, N.A.

    1993-01-01

    The results of measuring the characteristics of nuclei leaving the Ta target bombarded by 4,5 GeV bremsstrahlung photons are presented. The thick-target-trap technique is used. The radioactive residual nuclei were detected by the induced activity with the help of the Ge(Li) detector. The forward-backward nucleus ratio is measured, and the kinematical characteristics are calculated in the framework of the two-step vector model of velocities. The data analysis and systematization is carried out in comparison with the results of hardon-nuclear interactions

  17. Static and dynamic deformations of actinide nuclei

    International Nuclear Information System (INIS)

    Rozmej, P.

    1985-09-01

    The zero-point quadrupole-hexadecapole vibrations have been taken into account to calculate dynamical deformations for even-even actinide nuclei. The collective and intrinsic motions are separated according to the Born-Oppenheimer approximation. The collective Hamiltonian is constructed using the macroscopic-microscopic method in the potential energy part and the cranking model in the kinetic energy part. The BCS theory with a modified oscillator potential is applied to describe the intrinsic motion of nucleons. A new set of Nilsson potential parameters, which produces a much better description of the properties of light actinide nuclei, has also been found. (orig.)

  18. Selfconsistent theory of Coulomb mixing in nuclei

    International Nuclear Information System (INIS)

    Pyatov, N.I.

    1978-01-01

    The theory of isobaric states is considered according to the Coulomb mixing in nuclei. For a given form of the isovestor potential the separable residual interactions are constructed by means of the isotopic invariance principle. The strength parameter of the force is found from a selfconsistency condition. The charge dependent force is represented by the Coulomb effective potential. The theory of the isobaric states is developed using the random phase approximation. The Coulomb mixing effects in the ground and isobaric 0 + states of even-mass nuclei are investigated

  19. On the semiclassical description of rotating nuclei

    International Nuclear Information System (INIS)

    Durand, M.; Kunz, J.; Schuck, P.

    1983-01-01

    The technique of partial h-resummation is used to obtain semiclassical, i.e. average current distributions in the body fixed system of heavy nuclei. It thereby turns out that this average intrinsic current only flows in the nuclear surface. A Strutinsky smoothing of the current is also performed and gives nice agreement with the semiclassical results. We also show how one can incorporate superfluidity into the semiclassical treatment. To lowest order in h we find that the moment of inertia of superfluid nuclei is zero. The same result is obtained by a quantum mechanical calculation if the gap goes to infinity. The importance of including n-corrections is pointed out

  20. Hadronic interaction and structure of exotic nuclei

    International Nuclear Information System (INIS)

    Otsuka, Takaharu

    2009-01-01

    I will overview recent studies on the evolution of the shell structure in stable and exotic nuclei, and will show its relevance to hadronic interaction, including nuclear forces. This shell evolution is primarily due to the tensor force. The robust mechanism and some examples will be presented. Such examples include the disappearance of existing magic numbers and the appearance of new ones. The shell structure and existing limit of nuclei depend also on the three-body interaction in a specific way. I will sketch how the Δ-hole excitation induced three-body force (Fujita-Miyazawa force) modifies them. (author)

  1. Maris polarization in neutron-rich nuclei

    Science.gov (United States)

    Shubhchintak; Bertulani, C. A.; Aumann, T.

    2018-03-01

    We present a theoretical study of the Maris polarization effect and its application in quasi-free reactions to assess information on the structure of exotic nuclei. In particular, we explore the dependence of the polarization effect on neutron excess and neutron-skin thickness. We discuss the uncertainties in the calculations of triple differential cross sections and of analyzing powers due the choices of various nucleon-nucleon interactions and optical potentials and the limitations of the method. Our study implies that polarization variables in (p, 2p) reactions in inverse kinematics can be an effective probe of single-particle structure of nuclei in radioactive-beam facilities.

  2. Structure of neutron-rich nuclei

    International Nuclear Information System (INIS)

    Nazarewicz, W.; Oak Ridge National Lab., TN; Warsaw Univ.

    1997-11-01

    One of the frontiers of today's nuclear science is the ''journey to the limits'': of atomic charge and nuclear mass, of neutron-to-proton ratio, and of angular momentum. The new data on exotic nuclei are expected to bring qualitatively new information about the fundamental properties of the nucleonic many-body system, the nature of the nuclear interaction, and nucleonic correlations at various energy-distance scales. In this talk, current developments in nuclear structure of neutron-rich nuclei are discussed from a theoretical perspective

  3. Structure functions and correlations in nuclei

    International Nuclear Information System (INIS)

    Fantoni, S.

    1988-01-01

    In this paper the results obtained for the static structure function S(k) and the longitudinal structure function S L (k) of 3 H, 3 He and 4 He nuclei and nuclear matter are presented and discussed. The calculations have been performed using realistic wave functions obtained from Faddeev and variational theories. The Monte Carlo method has been used to calculate the structure functions of finite systems, and the FHNC/SOC method for nuclear matter. The results for the 3 He nucleus are in agreement with the recent Saclay data. The results for nuclear matter are compared with the experimental data relative to heavier nuclei, like e.g. 40 Ca

  4. Improved Fibroblast Functionalities by Microporous Pattern Fabricated by Microelectromechanical Systems

    OpenAIRE

    Wei, Hongbo; Zhao, Lingzhou; Chen, Bangdao; Bai, Shizhu; Zhao, Yimin

    2014-01-01

    Fibroblasts, which play an important role in biological seal formation and maintenance, determine the long-term success of percutaneous implants. In this study, well-defined microporous structures with micropore diameters of 10–60 µm were fabricated by microelectromechanical systems and their influence on the fibroblast functionalities was observed. The results show that the microporous structures with micropore diameters of 10–60 µm did not influence the initial adherent fibroblast number; ...

  5. Tumor-secreted LOXL2 activates fibroblasts through FAK signaling

    DEFF Research Database (Denmark)

    Barker, Holly E; Bird, Demelza; Lang, Georgina

    2013-01-01

    models. Here, we discovered that tumor-derived LOXL2 directly activated stromal fibroblasts in the tumor microenvironment. Genetic manipulation or antibody inhibition of LOXL2 in orthotopically grown mammary tumors reduced the expression of α-smooth muscle actin (α-SMA). Using a marker for reticular....... Importantly, in vitro assays revealed that tumor-derived LOXL2 and a recombinant LOXL2 protein induced fibroblast branching on collagen matrices, as well as increased fibroblast-mediated collagen contraction and invasion of fibroblasts through extracellular matrix. Moreover, LOXL2 induced the expression of α...

  6. DNA Measurement of Overlapping Cell Nuclei in Thick Tissue Sections

    Directory of Open Access Journals (Sweden)

    Liang Ji

    1997-01-01

    Full Text Available The paper describes an improved image analysis procedure for measuring the DNA content of cell nuclei in thick sections of liver tissue by absorption densitometry. Whereas previous methods only permitted the analysis of isolated nuclei, the new technique enables both isolated and overlapping nuclei to be measured. A 3D segmentation procedure determines whether each object is an isolated nucleus or a pair of overlapping nuclei; in the latter case the combined optical density is redistributed to the individual nuclei. A selection procedure ensures that only complete nuclei are measured.

  7. Immortalization of Werner syndrome and progeria fibroblasts

    International Nuclear Information System (INIS)

    Saito, H.; Moses, R.E.

    1991-01-01

    Human fibroblast cells from two different progeroid syndromes, Werner syndrome (WS) and progeria, were established as immortalized cell lines by transfection with plasmid DNA containing the SV40 early region. The lineage of each immortalized cell line was confirmed by VNTR analysis. Each of the immortalized cell lines maintained its original phenotype of slow growth. DNA repair ability of these cells was also studied by measuring sensitivity to killing by uv or the DNA-damaging drugs methyl methansulfonate, bleomycin, and cis-dichlorodiamine platinum. The results showed that both WS and progeria cells have normal sensitivity to these agents

  8. Coupling of cytoskeleton functions for fibroblast locomotion

    DEFF Research Database (Denmark)

    Couchman, J R; Lenn, M; Rees, D A

    1985-01-01

    caused visible protrusions in projected positions at the leading edge. We conclude that fibroblast locomotion may be driven coordinately by a common set of motility mechanisms and that this coordination may be lost as a result of physical or pharmacological disturbance. Taking our evidence with results...... from other Laboratories, we propose the following cytoskeleton functions. (i) Protrusive activity, probably based on solation--gelation cycles of the actin based cytoskeleton and membrane recycling which provides cellular and membrane components for streaming through the cell body to the leading edge...

  9. Differences in motility pattern between human buccal fibroblasts and periodontal and skin fibroblasts

    DEFF Research Database (Denmark)

    Lepekhin, Eugene; Grøn, Birgitte; Berezin, Vladimir

    2002-01-01

    at these sites can be explained by differences in the motile behavior of their respective fibroblast populations. The migratory characteristics were studied in a two-dimensional culture system. The migration of single cells was time-lapse video recorded at intervals of 15 min for a period of 6 h using a computer...

  10. Stability of the spherical form of nuclei

    International Nuclear Information System (INIS)

    Sabry, A.A.

    1976-08-01

    An extension of the mass formula for a spherical nucleus in the drop model to include a largely deformed nucleus of different forms is investigated. It is found that although the spherical form is stable under small deformations from equilibrium, there exists for heavier nuclei another more favourable stable form, which can be approximated by two, or three touching prolate ellipsoids of revolution

  11. High energy spin isospin modes in nuclei

    International Nuclear Information System (INIS)

    Chanfray, G.; Ericson, M.

    1984-01-01

    The high energy response of nuclei to a spin-isospin excitation is investigated. We show the existence of a strong contrast between the spin transverse and spin longitudinal responses. The second one undergoes a shadow effect in the Δ region and displays the occurrence of the pionic branch

  12. Transitional nuclei in the A∼100 region

    International Nuclear Information System (INIS)

    Petry, R.F.

    1986-01-01

    This is a report on nuclear structure studies funded by the Department of Energy over a seven-year period from August 1, 1979 to August 31, 1986. In summary, the work was concerned with nuclear structure in the A∼100 region. In particular the focus of the work was on odd-A deformed nuclei in this region with N > 60

  13. Contact nuclei formation in aqueous dextrose solutions

    Science.gov (United States)

    Cerreta, Michael K.; Berglund, Kris A.

    1990-06-01

    A laser Raman microprobe was used in situ to observe the growth of alpha dextrose monohydrate on alpha anhydrous dextrose crystals. The Raman spectra indicate growth of the monohydrate below 28.1°C, but the presence of only the anhydrous form above 40.5°C. Contact nucleation experiments with parent anhydrous crystals yielded only monohydrate nuclei below 28.1°C, while contacts in solutions between 34.5 and 41.0°C produced both crystalline forms, and contacts in solutions above 43.5°C produced only anhydrous nuclei. The inability of the monohydrate to grow on anhydrous crystals in the same solution that forms the two crystalline phases with a single contact precludes a simple attrition mechanism of nuclei formation. For the same reason, the hypothetical mechanism involving parent crystal stabilization of pre-crystalline clusters, allowing the clusters to grow into nuclei, is also contradicted. A third, mechanism, which may be a combination of the two, is believed to apply.

  14. Properties of semi-infinite nuclei

    International Nuclear Information System (INIS)

    El-Jaick, L.J.; Kodama, T.

    1976-04-01

    Several relations among density distributions and energies of semi-infinite and infinite nuclei are iventigated in the framework of Wilets's statistical model. The model is shown to be consistent with the theorem of surface tension given by Myers and Swiatecki. Some numerical results are shown by using an appropriate nuclear matter equation of state

  15. Electronuclear sum rules for the lightest nuclei

    International Nuclear Information System (INIS)

    Efros, V.D.

    1992-01-01

    It is shown that the model-independent longitudinal electronuclear sum rules for nuclei with A = 3 and A = 4 have an accuracy on the order of a percent in the traditional single-nucleon approximation with free nucleons for the nuclear charge-density operator. This makes it possible to test this approximation by using these sum rules. The longitudinal sum rules for A = 3 and A = 4 are calculated using the wave functions of these nuclei corresponding to a large set of realistic NN interactions. The values of the model-independent sum rules lie in the range of values calculated by this method. Model-independent expressions are obtained for the transverse sum rules for nuclei with A = 3 and A = 4. These sum rules are calculated using a large set of realistic wave functions of these nuclei. The contribution of the convection current and the changes in the results for different versions of realistic NN forces are given. 29 refs., 4 tabs

  16. Physics of the continuum of borromean nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Vaagen, J S; Rogde, T [Dept. of Physics, Univ. of Bergen (Norway); Danilin, B V [RRC The Kurchatov Inst., Kurchatov, Moscow (Russian Federation); Ershov, S N [JINR, Dubna, Moscow (Russian Federation); Thompson, I J [Dept. of Physics, Univ. of Surrey, Guildford (United Kingdom); Zhukov, M V [Chalmers Univ. of Technology and Goeteborg Univ., Goeteborg (Sweden); RNBT Collaboration

    1998-06-01

    The continuum states of two-neutron halo nuclei are calculated in the method of hyperspherical harmonics. Using DWIA theory appropriate for dilute halo matter we have probed the structure of the low-lying {sup 6}He continuum via calculations of charge-exchange and inelastic scattering. (orig.)

  17. Collective Quadrupole Excitations of Transactinide Nuclei

    CERN Document Server

    Zajac, K; Pomorski, K; Rohozinski, S G; Srebrny, J

    2003-01-01

    The quadrupole excitations of transuranic nuclei are described in the frame of the microscopic Bohr Hamiltonian modified by adding the coupling with the collective pairing vibrations. The energies of the states from the ground-state bands in U to No even-even isotopes as well as the B(E2) transition probabilities are reproduced within the model containing no adjustable parameters.

  18. Cloud condensation nuclei from biomass burning

    International Nuclear Information System (INIS)

    Rogers, C.F.; Hudson, J.G.; Zielinska, B.; Tanner, R.L.; Hallett, J.; Watson, J.G.

    1991-01-01

    In this work, the authors have analyzed biomass and crude oil smoke samples for ionic and organic species. The cloud condensation nuclei activities of the smoke particles are discussed in terms of the measured chemical compositions of the smoke samples. The implications of biomass burning to global climatic change are discussed

  19. Electron interactions with nuclei: Progress report

    International Nuclear Information System (INIS)

    1988-08-01

    This paper contains information on the following topics: inclusive electron scattering; electroexcitation of Δ in nuclei; longitudinal and transverse response in the quasi-elastic region; electron scattering at MIT-Bates; detector development at LEGS; electron scattering at Saclay; intermediate energy nuclear interactions; research and development at CEBAF; and computing facilities

  20. Structure functions of nucleons and nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Bentz, Wolfgang; Ito, Takuya [Department of Physics, Tokai University, Kanagawa (Japan); Cloet, Ian [Department of Physics, University of Washington, Seattle (United States); Thomas, Anthony [Jefferson Lab., Newport News, VA (United States); Yazaki, Koichi [RIKEN, Wako-shi, Saitama (Japan)

    2009-07-01

    We use an effective chiral quark theory to calculate the quark distributions and structure functions of nucleons and nuclei. The description of the single nucleon is based on the Faddeev framework, and nuclear systems are described in the mean field approximation. Particular amphasis is put on the prediction of the polarized EMC effect in nuclei, and on applications to deep inelastic neutrino-nucleus scattering. Concerning the polarized EMC effect, we discuss the quenching of the quark spin sum in nuclei and its implications for the spin dependent nuclear structure functions, and present results for several nuclei where an experimental observation is feasible. Concerning the case of deep inelastic neutrino-nucleus scattering, we estimate the effect of medium modifications of the quark distribution functions on the measured cross sections, and discuss an interesting resolution of the so called NuTeV anomaly. Finally, we discuss extensions of our model to describe fragmentation functions for semi-inclusive processes. The connection between our effective quark model description and the jet model of Field and Feynman is discussed.

  1. Quasars: Active nuclei of young galaxies

    Science.gov (United States)

    Komberg, B. V.

    1980-01-01

    The hypothetical properties of 'young' galaxies and possible methods of observing them are discussed. It is proposed that star formation first takes place in the central regions of protogalaxies which may appear as quasar-like objects. An evolutionary scheme is outlined in which the radio quasars are transformed in time into the nuclei of radio galaxies.

  2. Fisica degli atomi e dei nuclei

    CERN Document Server

    Bernardini, Carlo

    1965-01-01

    Evidenza della struttura atomica della materia ; le proprietà degli atomi e la meccanica atomica ; gli atomi e le radiazioni elettromagnetiche ; struttura microscopica dello stato gassoso ; struttura microscopica dello stato liquido ; struttura microscopica della stato solido ; proprietà elettriche e magnetiche delle sostanze ; proprietà dei nuclei degli atomi ; le particelle elementari.

  3. Meson degrees of freedom in nuclei

    International Nuclear Information System (INIS)

    Delorme, J.

    1982-01-01

    A review is presented of the successes and shortcomings of the theory of meson degrees of freedom in nuclei with special emphasis on recent progress and on the necessity to bridge the gap with the degrees of freedom of QCD theory. (orig.)

  4. Thomas-Fermi model of warm nuclei

    International Nuclear Information System (INIS)

    Buchler, J.R.; Epstein, R.I.

    1980-01-01

    The average nuclear level density of spherical nuclei is computed with a finite temperature Thomas-Fermi model. More than 80% of the low energy nuclear excitations can be accounted for in terms of this statistical model. The relevance for stellar collapse is discussed

  5. Decay of heavy and superheavy nuclei

    Indian Academy of Sciences (India)

    April 2014 physics pp. 705–715. Decay of heavy and superheavy nuclei ... study on the feasibility of observing α decay chains from the isotopes of the ... studies on 284−286115 and 288−292117 will be a guide to future experiments. .... ratio of the α decay from the ground state of the parent nucleus to the level i of the.

  6. Spectroscopic Studies of Exotic Nuclei at ISOLDE

    CERN Multimedia

    2002-01-01

    Experiment IS50 is designed to: a) Investigate the full range of the @b strength function of heavy (A~$>$~48)~K nuclei b)~Study the decay of isomeric states in n-deficient bromine nuclei (A~=~72 and 70). The heavy K isotopes appeared to have complex decay schemes, including feeding by the @b-decay of levels having open neutron channels (Beta decay energy Q(@b) exceeds neutron binding energy S^n); in addition, a large fraction of the delayed transitions populate excited levels in the daughter nuclei. The allowed @b-decay selects states in the daughter nucleus with wave functions having a large overlap with the initial state. Hence, the @b strength functions, deduced from these deca reveal simple structures correlated to the particle-hole excitation energies in the Ca nuclei. These results are valuable for the application of the shell-model calculations far from stability. The delayed neutron spectra are measured with a large area curved scintillator in coincidence either with high resolution Ge(Li) detectors, ...

  7. Polarization electric dipole moment in nonaxial nuclei

    International Nuclear Information System (INIS)

    Denisov, V.Yu.; Davidovskaya, O.I.

    1996-01-01

    An expression for the macroscopic polarization electric dipole moment is obtained for nonaxial nuclei whose radii of the proton and neutron surfaces are related by a linear equation. Dipole transitions associated with the polarization electric dipole moment are analyzed for static and dynamical multipole deformations

  8. Growth and Interaction of Colloid Nuclei

    Science.gov (United States)

    Lam, Michael-Angelo; Khusid, Boris; Meyer, William; Kondic, Lou

    2017-11-01

    We study evolution of colloid systems under zero-gravity conditions. In particular, we focus on the regime where there is a coexistence between a liquid and a solid state. Under zero gravity, the dominating process in the bulk of the fluid phase and the solid phase is diffusion. At the moving solid/liquid interface, osmotic pressure is balanced by surface tension, as well as balancing fluxes (conservation of mass) with the kinematics of nuclei growth (Wilson-Frenkel law). Due to the highly nonlinear boundary condition at the moving boundary, care has to be taken when performing numerical simulations. In this work, we present a nonlinear model for colloid nuclei growth. Numerical simulations using a finite volume method are compared with asymptotic analysis of the governing equation and experimental results for nuclei growth. Novel component in our numerical simulations is the inclusion of nonlinear (collective) diffusion terms that depend on the chemical potentials of the colloid in the solid and fluid phase. The results include growth and dissolution of a single colloidal nucleus, as well as evolution of multiple interacting nuclei. Supported by NASA Grant No. NNX16AQ79G.

  9. Radiative muon capture on nuclei and protons

    International Nuclear Information System (INIS)

    Azuelos, G.; Gorringe, T.P.; Henderson, R.; Macdonald, J.A.; Poutissou, J.M.; Azuelos, G.; Depommier, P.; Poutissou, R.; Ahmad, S.; Burnham, A.; Hasinoff, M.D.; Larabee, A.J.; Waltham, C.E.; Wright, D.H.; Armstrong, D.S.; Blecher, M.; Serna-Angel, A.; Bertl, W.; Chen, C.Q.; Zhang, N.S.; McDonald, S.C.; Taylor, G.N.; Robertson, B.C.

    1990-01-01

    A brief review is made of the study of gp, the induced pseudoscalar coupling constant, in radiative muon capture on light nuclei, and of motivations for a measurement on hydrogen, with particular emphasis on recent and ongoing experiments at TRIUMF [fr

  10. Electron form factors of deformable nuclei

    International Nuclear Information System (INIS)

    Tartakovskii, V.K.; Isupov, V.Yu.

    1988-01-01

    Using the smallness of the deformation parameter of the nucleus, we obtain simple explicit expressions for the form factors of electroexcitation of the low-lying rotation-vibration states of light, deformable, even-even nuclei. The expressions satisfactorily describe the experimental data on the excitation of collective nuclear states by the inelastic scattering of fast electrons

  11. Superheavy nuclei – cold synthesis and structure

    Indian Academy of Sciences (India)

    120 and Ж = 172 or 184, for superheavy nuclei. This result is discussed in ... 1980 [7] on the basis of the QMFT, once again prior to its observation in 1984. Thus, cold ... On the other hand, based on a rather complete deformed relativistic mean field (DRMF) calculation, using the NL1 parameter set, we [16] predicted. = 120.

  12. Efimov effect in 2-neutron halo nuclei

    Indian Academy of Sciences (India)

    This paper presents an overview of our theoretical investigations in search of Efimov states in light 2-neutron halo nuclei. The calculations have been carried out within a three-body formalism, assuming a compact core and two valence neutrons forming the halo. The calculations provide strong evidence for the occurrence ...

  13. Replacement of murine fibroblasts by human fibroblasts irradiated in obtaining feeder layer for the culture of human keratinocytes

    International Nuclear Information System (INIS)

    Yoshito, Daniele; Sufi, Bianca S.; Santin, Stefany P.; Mathor, Monica B.; Altran, Silvana C.; Isaac, Cesar

    2011-01-01

    Human autologous epithelia cultivated in vitro, have been used successfully in treating damage to skin integrity. The methodology allowed the cultivation of these epithelia was described by Rheinwald and Green in 1975, this methodology consisted in seeding keratinocytes onto a feeder layer composed of lineage 3T3 murine fibroblasts, the proliferation rate is controlled through the action of ionizing radiation. However, currently there is a growing concern about the possibility of transmitting prions and murine viruses to transplanted patients. Taking into account this concern, in this present work, we replaced the feeder layer originally composed of murine fibroblasts by human fibroblasts. To obtain this new feeder layer was necessary to standardize the enough irradiation dose to inhibit the replication of human fibroblasts and the verification of effectiveness of the development of keratinocytes culture on a feeder layer thus obtained. According to the obtained results we can verify that the human fibroblasts irradiated at various tested doses (60, 70, 100, 200, 250 and 300 Gy) had their mitotic activity inactivated by irradiation, allowing the use of any of these doses to confection of the feeder layer, since these fibroblasts irradiated still showed viable until fourteen days of cultivation. In the test of colony formation efficiency was observed that keratinocytes seeded on irradiated human fibroblasts were able to develop satisfactorily, preserving their clonogenic potential. Therefore it was possible the replacement of murine fibroblasts by human fibroblasts in confection of the feeder layer, in order to eliminate this xenobiotic component of the keratinocytes culture. (author)

  14. Replacement of murine fibroblasts by human fibroblasts irradiated in obtaining feeder layer for the culture of human keratinocytes

    Energy Technology Data Exchange (ETDEWEB)

    Yoshito, Daniele; Sufi, Bianca S.; Santin, Stefany P.; Mathor, Monica B. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Altran, Silvana C.; Isaac, Cesar [Universidade Sao Paulo (USP), Sao Paulo, SP (Brazil). Fac. de Medicina. Lab. de Microcirurgia Plastica; Esteves-Pedro, Natalia M. [Universidade Sao Paulo (USP), Sao Paulo, SP (Brazil). Fac. de Ciencias Farmaceuticas. Lab. de Controle Biologico; Herson, Marisa R. [DonorTissue Bank of Victoria (Australia)

    2011-07-01

    Human autologous epithelia cultivated in vitro, have been used successfully in treating damage to skin integrity. The methodology allowed the cultivation of these epithelia was described by Rheinwald and Green in 1975, this methodology consisted in seeding keratinocytes onto a feeder layer composed of lineage 3T3 murine fibroblasts, the proliferation rate is controlled through the action of ionizing radiation. However, currently there is a growing concern about the possibility of transmitting prions and murine viruses to transplanted patients. Taking into account this concern, in this present work, we replaced the feeder layer originally composed of murine fibroblasts by human fibroblasts. To obtain this new feeder layer was necessary to standardize the enough irradiation dose to inhibit the replication of human fibroblasts and the verification of effectiveness of the development of keratinocytes culture on a feeder layer thus obtained. According to the obtained results we can verify that the human fibroblasts irradiated at various tested doses (60, 70, 100, 200, 250 and 300 Gy) had their mitotic activity inactivated by irradiation, allowing the use of any of these doses to confection of the feeder layer, since these fibroblasts irradiated still showed viable until fourteen days of cultivation. In the test of colony formation efficiency was observed that keratinocytes seeded on irradiated human fibroblasts were able to develop satisfactorily, preserving their clonogenic potential. Therefore it was possible the replacement of murine fibroblasts by human fibroblasts in confection of the feeder layer, in order to eliminate this xenobiotic component of the keratinocytes culture. (author)

  15. Toll-like receptor 9 mediated responses in cardiac fibroblasts.

    Directory of Open Access Journals (Sweden)

    Ingrid Kristine Ohm

    Full Text Available Altered cardiac Toll-like receptor 9 (TLR9 signaling is important in several experimental cardiovascular disorders. These studies have predominantly focused on cardiac myocytes or the heart as a whole. Cardiac fibroblasts have recently been attributed increasing significance in mediating inflammatory signaling. However, putative TLR9-signaling through cardiac fibroblasts remains non-investigated. Thus, our aim was to explore TLR9-signaling in cardiac fibroblasts and investigate the consequence of such receptor activity on classical cardiac fibroblast cellular functions. Cultivated murine cardiac fibroblasts were stimulated with different TLR9 agonists (CpG A, B and C and assayed for the secretion of inflammatory cytokines (tumor necrosis factor α [TNFα], CXCL2 and interferon α/β. Expression of functional cardiac fibroblast TLR9 was proven as stimulation with CpG B and -C caused significant CXCL2 and TNFα-release. These responses were TLR9-specific as complete inhibition of receptor-stimulated responses was achieved by co-treatment with a TLR9-antagonist (ODN 2088 or chloroquine diphosphate. TLR9-stimulated responses were also found more potent in cardiac fibroblasts when compared with classical innate immune cells. Stimulation of cardiac fibroblasts TLR9 was also found to attenuate migration and proliferation, but did not influence myofibroblast differentiation in vitro. Finally, results from in vivo TLR9-stimulation with subsequent fractionation of specific cardiac cell-types (cardiac myocytes, CD45+ cells, CD31+ cells and cardiac fibroblast-enriched cell-fractions corroborated our in vitro data and provided evidence of differentiated cell-specific cardiac responses. Thus, we conclude that cardiac fibroblast may constitute a significant TLR9 responder cell within the myocardium and, further, that such receptor activity may impact important cardiac fibroblast cellular functions.

  16. Fibroblastic connective tissue nevus: Clinicopathological and immunohistochemical study of 14 cases.

    Science.gov (United States)

    Pennacchia, Ilaria; Kutzner, Heinz; Kazakov, Dmitry V; Mentzel, Thomas

    2017-10-01

    We present herein a series of 14 lesions showing overlapping features with the newly defined benign cutaneous mesenchymal neoplasm labeled as fibroblastic connective tissue nevus (FCTN). Total of 8 patients were male and 5 were female, ranging in age from 1 to 56 years. Lesions appeared as isolated nodules or plaques on the trunk (7 cases), the limbs (4 cases) and the neck (2 cases). Histologically, all cases were composed of bundles of bland spindle cells of fibroblastic/myofibroblastic lineage irregularly branching within the reticular dermis and along fibrous septa in the subcutis. Adnexal structures and dermal adipocytes were entrapped by the fascicles, the epidermis was often papillomatous and elastic fibers were decreased and fragmented. Expression of CD34 and ASMA was found in 8 and 7 cases, respectively. Follow-up was available for 7 patients (mean follow-up, 5 years; range, 1-10 years). None of the cases metastasized or recurred, even when incompletely excised. The differential diagnosis of FCTN is broad and includes hypertrophic scar, dermatofibroma, dermatomyofibroma, pilar leiomyoma, plaque-stage DFSP, CD34-positive plaque-like dermal fibroma, fibroblastic-predominant plexiform fibrohistiocytic tumor, lipofibromatosis, superficial desmoid fibromatosis and fibrous hamartoma of infancy, of which it represents probably the monophasic variant. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. Myogenic conversion of bladder fibroblasts by construction and ...

    African Journals Online (AJOL)

    The cultured primary bladder fibroblasts were transfected by pEGFP-Myod1 with Lipofection 2000 reagent. The results showed that expression of Myod1 could cause myogenic differentiation of bladder fibroblasts. These findings support the possibility of an alternative approach to exploit the capacity of Myod1 to activate ...

  18. Rac inhibition reverses the phenotype of fibrotic fibroblasts.

    Directory of Open Access Journals (Sweden)

    Shi-wen Xu

    Full Text Available BACKGROUND: Fibrosis, the excessive deposition of scar tissue by fibroblasts, is one of the largest groups of diseases for which there is no therapy. Fibroblasts from lesional areas of scleroderma patients possess elevated abilities to contract matrix and produce alpha-smooth muscle actin (alpha-SMA, type I collagen and CCN2 (connective tissue growth factor, CTGF. The basis for this phenomenon is poorly understood, and is a necessary prerequisite for developing novel, rational anti-fibrotic strategies. METHODS AND FINDINGS: Compared to healthy skin fibroblasts, dermal fibroblasts cultured from lesional areas of scleroderma (SSc patients possess elevated Rac activity. NSC23766, a Rac inhibitor, suppressed the persistent fibrotic phenotype of lesional SSc fibroblasts. NSC23766 caused a decrease in migration on and contraction of matrix, and alpha-SMA, type I collagen and CCN2 mRNA and protein expression. SSc fibroblasts possessed elevated Akt phosphorylation, which was also blocked by NSC23766. Overexpression of rac1 in normal fibroblasts induced matrix contraction and alpha-SMA, type I collagen and CCN2 mRNA and protein expression. Rac1 activity was blocked by PI3kinase/Akt inhibition. Basal fibroblast activity was not affected by NSC23766. CONCLUSION: Rac inhibition may be considered as a novel treatment for the fibrosis observed in SSc.

  19. Mesenchymal stem cells induce dermal fibroblast responses to injury

    International Nuclear Information System (INIS)

    Smith, Andria N.; Willis, Elise; Chan, Vincent T.; Muffley, Lara A.; Isik, F. Frank; Gibran, Nicole S.; Hocking, Anne M.

    2010-01-01

    Although bone marrow-derived mesenchymal stem cells have been shown to promote repair when applied to cutaneous wounds, the mechanism for this response remains to be determined. The aim of this study was to determine the effects of paracrine signaling from mesenchymal stem cells on dermal fibroblast responses to injury including proliferation, migration and expression of genes important in wound repair. Dermal fibroblasts were co-cultured with bone marrow-derived mesenchymal stem cells grown in inserts, which allowed for paracrine interactions without direct cell contact. In this co-culture model, bone marrow-derived mesenchymal stem cells regulate dermal fibroblast proliferation, migration and gene expression. When co-cultured with mesenchymal stem cells, dermal fibroblasts show increased proliferation and accelerated migration in a scratch assay. A chemotaxis assay also demonstrated that dermal fibroblasts migrate towards bone marrow-derived mesenchymal stem cells. A PCR array was used to analyze the effect of mesenchymal stem cells on dermal fibroblast gene expression. In response to mesenchymal stem cells, dermal fibroblasts up-regulate integrin alpha 7 expression and down-regulate expression of ICAM1, VCAM1 and MMP11. These observations suggest that mesenchymal stem cells may provide an important early signal for dermal fibroblast responses to cutaneous injury.

  20. Probing the density tail of radioactive nuclei with antiprotons

    CERN Document Server

    Obertelli, Alexandre; Uesaka, Tomohiro; Corsi, Anna; Pollacco, Emmanuel; Flavigny, Freddy

    2017-01-01

    We propose an experiment to determine the proton and neutron content of the radial density tail in short-lived nuclei. The objectives are to (i) to evidence new proton and neutron halos, (ii) to understand the development of neutron skins in medium-mass nuclei, (iii) to provide a new observable that characterises the density tail of short-lived nuclei.

  1. Incidence of centrally positioned nuclei in mouse masticatory muscle fibers

    DEFF Research Database (Denmark)

    Vilmann, A; Vilmann, H; Kirkeby, S

    1989-01-01

    Cross-sections of normal digastric, temporalis and masseter muscles from 7- and 30-week-old mice were studied for centrally positioned nuclei. Such nuclei were inhomogeneously distributed throughout each muscle and varied markedly between specimens. The incidence of centrally positioned nuclei in...

  2. The Role of Broken Cooper Pairs in Warm Nuclei

    International Nuclear Information System (INIS)

    Guttormsen, M.; Chankova, R.; Larsen, A.C.; Rekstad, J.; Siem, S.; Syed, N.U.H.; Agvaanluvsan, U.; Schiller, A.; Voinov, A.

    2007-01-01

    In order to understand warm nuclei and describe the underlying microscopic structure, entropy is measured for several even-even and odd-mass nuclei. Mid-shell nuclei show significant odd-even entropy differences interpreted as the single-particle entropy introduced by the valence nucleon. A method to extract critical temperatures for the pair breaking process is demonstrated. (author)

  3. The intriguing role of fibroblasts and c-Jun in the chemopreventive and therapeutic effect of finasteride on xenograft models of prostate cancer

    Directory of Open Access Journals (Sweden)

    Yi-Nong Niu

    2016-01-01

    Full Text Available In a large clinical trial, finasteride reduced the rate of low-grade prostate cancer (PCa while increasing the incidence of high-grade cancer. Whether finasteride promotes the development of high-grade tumors remains controversial. We demonstrated the role of fibroblasts and c-Jun in chemopreventive and therapeutic effect of finasteride on xenograft models of PCa. LNCaP (PC3 cells or recombinants of cancer cells and fibroblasts were implanted in male athymic nude mice treated with finasteride. Tumor growth, cell proliferation, apoptosis, p-Akt, and p-ERK1/2 were evaluated. In LNCaP (PC3 mono-grafted models, finasteride did not change the tumor growth. In recombinant-grafted models, fibroblasts and c-Jun promoted tumor growth; finasteride induced proliferation of LNCaP cells and repressed PC3 cell apoptosis. When c-Jun was knocked out, fibroblasts and/or finasteride did not promote the tumor growth. Finasteride inhibited p-Akt and p-ERK1/2 in mono-culture cancer cells while stimulating the same signaling molecules in the presence of fibroblasts. Reduced p-Akt and p-ERK1/2 were noted in the presence of c-Jun−/− fibroblasts. Fibroblasts and c-Jun promote PCa growth; finasteride further stimulates tumor growth with promoted proliferation, repressed apoptosis, and up-regulated pro-proliferative molecular pathway in the presence of fibroblasts and c-Jun. Stromal-epithelial interactions play critical roles in finasteride′s therapeutic effects on PCa. Our findings have preliminary implications in using finasteride as a chemopreventive or therapeutic agent for PCa patients.

  4. Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease

    Science.gov (United States)

    Gourdie, Robert G.; Dimmeler, Stefanie; Kohl, Peter

    2016-01-01

    Our understanding of cardiac fibroblast functions has moved beyond their roles in heart structure and extracellular matrix generation, and now includes contributions to paracrine, mechanical and electrical signalling during ontogenesis and normal cardiac activity. Fibroblasts have central roles in pathogenic remodelling during myocardial ischaemia, hypertension and heart failure. As key contributors to scar formation, they are crucial for tissue repair after interventions including surgery and ablation. Novel experimental approaches targeting cardiac fibroblasts are promising potential therapies for heart disease. Indeed, several existing drugs act, at least partially, through effects on cardiac connective tissue. This Review outlines the origins and roles of fibroblasts in cardiac development, homeostasis and disease; illustrates the involvement of fibroblasts in current and emerging clinical interventions; and identifies future targets for research and development. PMID:27339799

  5. Inelastic collisions of neon-22 nuclei with nuclei in photoemulsion at 90 GeV/c momentum

    International Nuclear Information System (INIS)

    Vokalova, A.; Krasnov, S.A.; Tolstov, K.D.

    1985-01-01

    The experimental data obtained according to the analysis of 4303 inelastic interactions of the relativistic neon-22 nuclei with the nuclei in photoemulsion are presented. The multiplicities and angular distributions are shown as the functions of the disintegration degree of the colliding nuclei. It is shown that the same number of interacting nucleons of the projectile neon and carbon nuclei are connected with the different impact parameters with the target nucleus

  6. Doubling potential of fibroblasts from different species after ionising radiation

    International Nuclear Information System (INIS)

    Macieira-Coelho, A.; Diatloff, C.; Malaise, E.

    1976-01-01

    It is stated that whereas chicken fibroblasts invariably die after a certain number of doublings in vitro, and this fact is never altered by chemical or physical agents, mouse fibroblasts invariably acquire spontaneously an infinite growth potential. In the human species fibroblasts never acquire spontaneously the capacity to divide for ever, although they can become permanent cell lines after treatment with certain viruses. This behaviour of fibroblasts in vitro has been attributed to different nutritional requirements. Experiments are described with human and mouse fibroblasts in which it was found that the response to ionising radiation matches the relative tendencies of the fibroblasts to yield permanent cell lines. Irradiation was commenced during the phase of active proliferation. Human fibroblast cultures irradiated with 100 R stopped dividing earlier than the controls, whereas cultures irradiated with 200, 300 and 500 R had the same lifespan as the control cultures. Cultures irradiated with 400 R showed the longest survival. With mouse fibroblasts the growth curves of the irradiated cells were of the same type as in the controls, but recovery occurred earlier. The results indicated that ionising radiation accelerates a natural phenomenon; in cells with a limited growth potential (chicken) it shortens the lifespan, whereas in cells that can acquire an unlimited growth potential (mouse) it accelerates acquisition of this potential; human fibroblasts showed an intermediate response, since ionising radiation neither established the cultures as with mouse cells nor reduced the number of cells produced as with chicken fibroblasts. Possible explanations for the different behaviour of the species are offered. (U.K.)

  7. Decay and fission of the oriented nuclei

    CERN Document Server

    Kadmenskij, S G

    2002-01-01

    The fragment angular distributions for binary decay of oriented spherical and deformed nuclei with taking into account the correct transformational properties of wave functions under time inversion have been investigated. It has been shown that for description of fragment angular distributions the adiabatic approximation for collective rotational nuclear degrees of freedom is not correct. It has been demonstrated that this approximation is valid for description of spontaneous and induced low-energy nuclear fission. The dependence of partial fission widths on the orientation of the internal axes spins, projections of spins, and relative angular moments of fission fragments has been analyzed. It has been shown that the adiabatic approximation results in coherent interference of wave functions of fragments relative movement. This interference forms fragments the universal angular distributions of fission fragments for oriented nuclei. For these distributions the deviations from A. Bohr's formula have been invest...

  8. Nuclear structure investigations on spherical nuclei

    International Nuclear Information System (INIS)

    Heisenberg, J.; Calarco, J.; Dawson, J.; Hersman, F.W.

    1989-09-01

    This report discusses the following topics: electron scattering studies on spherical nuclei; electron scattering from collective states in deformed nuclei; proton and pion scattering studies; 12 C(e,e'p) and 16 O(e,e'p); 12 C(e,e'α) and 16 O(e,e'α); studies at high q at Bates; measurements with rvec e at Bates; 12 C(γ,p); future directions in giant resonance studies; proton knockout from 16 O; quasielastic studies at Bates; triple coincidence studies of nuclear correlations; contributions to (e,e'2p) at KIKHEF; contributions to instrumentation at CEBAF; instrumentation development at UNH; the Bates large acceptance spectrometer toroid; shell model and core polarization calculations; and the relativistic nuclear model

  9. Nuclei at HERA and heavy ion physics

    International Nuclear Information System (INIS)

    Gavin, S.; Strikman, M.

    1995-01-01

    Copies of 16 viewgraph sets from a workshop held at Brookhaven National Laboratory, 17-18 November, 1995. Titles of talks: HERA: The Present; HERA: Potential with Nuclei; Review of Hadron-Lepton Nucleus Data; Fermilab E665: results in muon scattering; Interactions of Quarks and Gluons with Nuclear Matter; Rescattering in Nuclear Targets for Photoproduction and DIS; Structure Functions and Nuclear Effect at PHENIX; Probing Spin-Averaged and Spin-Dependent Parton Distributions Using the Solenoidal Tracker at RHIC (STAR); Jet Quenching in eA, pA, AA; Nuclear Gluon Shadowing via Continuum Lepton Pairs; What can we learn from HERA with a colliding heavy ion beam? The limiting curve of leading particles at infinite A; Coherent Production of Vector Mesons off Light Nuclei in DIS; A Model of High Parton Densities in PQCD; Gluon Production for Weizaecker-Williams Field in Nucleus-Nucleus Collisions; Summary Talk

  10. Transmission coefficents in strongly deformed nuclei

    International Nuclear Information System (INIS)

    Aleshin, V.P.

    1996-01-01

    By using our semiclassical approach to particle evaporation from deformed nuclei developed earlier, we analyze here the heuristic methods of taking into account the effects of shape deformations on particle emission. These methods are based on the 'local' transmission coefficients in which the effective barrier depends on the angle with respect to the symmetry axis. The calculations revealed that the heuristic models are reasonable for particle energy spectra but fail, at large deformations, to describe the angular distributions. In A∼160 nuclei with axis ratio in the vicinity of 2:1 at temperatures of 2-3 MeV, the W (90 )/W(0 ) anisotropies of α particles with respect to the nuclear spin are 1.5 to 3 times larger than our approach predicts. The influence of spin alignment on particle energy spectra is discussed shortly. (orig.)

  11. Intruder bands in Z = 51 nuclei

    International Nuclear Information System (INIS)

    LaFosse, D.R.

    1993-01-01

    Recent investigations of h 11/2 proton intruder bands in odd 51 Sb nuclei are reported. In addition to experiments performed at SUNY Stony Brook and Chalk River, data from Early Implementation of GAMMASPHERE (analysis in progress) are presented. In particular, the nuclei 109 Sb and 111 Sb are discussed. Rotational bands based on the πh 11/2 orbital coupled to a 2p2h deformed state of the 50 Sn core have been observed. These bands have been observed to high spin, and in the case of 109 Sb to a rotational frequency of 1.4 MeV, the highest frequency observed in a heavy nucleus. The dynamic moments of inertia in these bands decrease slowly with frequency, suggesting a gradual band termination. The systematics of such bands in 109-119 Sb will be discussed

  12. Shell model for warm rotating nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Matsuo, M.; Yoshida, K. [Kyoto Univ. (Japan); Dossing, T. [Univ. of Copenhagen (Denmark)] [and others

    1996-12-31

    Utilizing a shell model which combines the cranked Nilsson mean-field and the residual surface and volume delta two-body forces, the authors discuss the onset of rotational damping in normal- and super-deformed nuclei. Calculation for a typical normal deformed nucleus {sup 168}Yb indicates that the rotational damping sets in at around 0.8 MeV above the yrast line, and about 30 rotational bands of various length exists at a given rotational frequency, in overall agreement with experimental findings. It is predicted that the onset of rotational damping changes significantly in different superdeformed nuclei due to the variety of the shell gaps and single-particle orbits associated with the superdeformed mean-field.

  13. Collective properties of drip-line nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Hamamoto, I. [Univ. of Lund (Sweden); Sagawa, H. [Univ. of Aizu, Fukushima (Japan)

    1996-12-31

    Performing the spherical Hartree-Fock (HF) calculations with Skyrme interactions and, then, using RPA solved in the coordinate space with the Green`s function method, the authors have studied the effect of the unique shell structure as well as the very low particle threshold on collective modes in drip line nuclei. In this method a proper strength function in the continuum is obtained, though the spreading width of collective modes is not included. They have examined also one-particle resonant states in the obtained HF potential. Unperturbed particle-hole (p-h) response functions are carefully studied, which contain all basic information on the exotic behaviour of the RPA strength function in drip line nuclei.

  14. Antiproton Induced Fission and Fragmentation of Nuclei

    CERN Multimedia

    2002-01-01

    The annihilation of slow antiprotons with nuclei results in a large highly localized energy deposition primarily on the nuclear surface. \\\\ \\\\ The study of antiproton induced fission and fragmentation processes is expected to yield new information on special nuclear matter states, unexplored fission modes, multifragmentation of nuclei, and intranuclear cascades.\\\\ \\\\ In order to investigate the antiproton-nucleus interaction and the processes following the antiproton annihilation at the nucleus, we propose the following experiments: \\item A)~Measurement of several fragments from fission and from multifragmentation in coincidence with particle spectra, especially neutrons and kaons. \\item B)~Precise spectra of $\\pi$, K, n, p, d and t with time-of-flight techniques. \\item C)~Installation of the Berlin 4$\\pi$ neutron detector with a 4$\\pi$ Si detector placed inside for fragments and charged particles. This yields neutron multiplicity distributions and consequently distributions of thermal excitation energies and...

  15. EMC effect and multiquark bags in nuclei

    International Nuclear Information System (INIS)

    Kondratyuk, L.; Shmatikov, M.

    1984-01-01

    Assuming existence of 9q- and 12q bags in niclei the form factors of light nuclei at large momentum transfers and structure functions of deep inelastic scattering of leptons on nuclei are described. It is shown that the existing experimental data can be described in a unified way provided the momentum distribution of quarks in multiquark bags at k 0 has the exponential form PSIsub(q)sup(2)(k) approximately esup(-k/k 0 ) with the parameter k 0 approximately 50-60 MeV. Theoretical results agree well the EMC experimental data on the ratio of the iron and deuteron structure functions with the 20% admixture of 12q-bags in the Fe nucleus

  16. SP (4,R) symmetry in light nuclei

    International Nuclear Information System (INIS)

    Peterson, D.R.

    1979-01-01

    A classification of nuclear states according to the noncompact sympletic Lie algebras sp(2n,R), n = 1, 2, 3, is investigated. Such a classification has recently been shown to be physically meaningful. This classification scheme is the appropriate generalization fo Elliott's SU 3 model of rotational states in deformed light nuclei to include core excitations. A restricted classification according to the Lie algebra, sp(4,R), is motivated. Truncation of the model space to a single sp(4,R) irreducible representation allows the inclusion of states possessing very high excitation energy. An sp(4,R) model study is performed on S = T = 0 positive-parity rotational bands in the deformed light nuclei 16 O and 24 Mg. States are included in the model space that possess up to 10h ω in excitation energy. Results for the B(E2) transition rates compare favorable with experiment, without resort to effective charges

  17. Order in nuclei and transition to chaos

    International Nuclear Information System (INIS)

    Soloviev, V.G.

    1995-01-01

    Based on the statement that there is order in the large and chaos in the small components of nuclear wave functions, the order-to-chaos transition is treated as a transition from the large to small components of wave functions. Therefore, experimental investigation of fragmentation of the many-quasiparticle and quasiparticle-phonon states plays a decisive role. The mixing of closely-spaced states having the same K π in the doubly even well-deformed nuclei is investigated. The quasiparticle-phonon interaction is responsible for fragmentation of the quasiparticle and phonon states and therefore for their mixing. Experimental investigation of the strength distribution of the many-quasiparticle and quasiparticle-phonon states should discover a new region of regularity in nuclei at intermediate excitation energies. A chaotic behaviour of nuclear states can be shifted to higher excitation energies. (author). 21 refs., 1 fig., 1 tab

  18. Order in nuclei and transition to chaos

    International Nuclear Information System (INIS)

    Soloviev, V.G.

    1995-01-01

    Based on the statement that there is order in the large and chaos in the small components of nuclear wave functions, the order-to-chaos transition is treated as a transition from the large to small components of wave functions. Therefore, experimental investigation of fragmentation of the many-quasiparticle and quasiparticle-phonon states a decisive role. The mixing of closely-spaced states having the same K π in the doubly even well-deformed nuclei is investigated. The quasiparticle-phonon interaction is responsible for fragmentation of the quasiparticle and phonon states and therefore for their mixing. Experimental investigation of the strength distribution of the many-quasiparticle and quasiparticle-phonon states should discover a new region of regularity in nuclei at intermediate excitation energies. A chaotic behaviour of nuclear states can be shifted to higher excitation energies. (author). 21 refs., 1 fig., 1 tab

  19. Isospin Mixing In N $\\approx$ Z Nuclei

    CERN Multimedia

    Srnka, D; Versyck, S; Zakoucky, D

    2002-01-01

    Isospin mixing in N $\\approx$ Z nuclei region of the nuclear chart is an important phenomenon in nuclear physics which has recently gained theoretical and experimental interest. It also forms an important nuclear physics correction in the precise determination of the $ft$-values of superallowed 0$^+ \\rightarrow 0^+ \\beta$- transitions. The latter are used in precision tests of the weak interaction from nuclear $\\beta$- decay. We propose to experimentally measure isospin mixing into nuclear ground states in the N $\\approx$ Z region by determining the isospin forbidden Fermi-component in the Gamow-Teller dominated $J^{\\pi} \\rightarrow J^{\\pi} \\beta$- transitions through the observation of anisotropic positron emission from oriented nuclei. First measurements were carried out with $^{71}$As and are being analyzed now.

  20. Electron interactions with nuclei: Progress report

    International Nuclear Information System (INIS)

    McCarthy, J.S.

    1987-08-01

    High energy is being conducted at the Stanford Linear Accelerator Center. This includes inclusive electron scattering, electroexcitation of the delta in nuclei, longitudinal and transverse response in the quasi-elastic region, the q 2 dependence of 4 He(e,e'p), deep inelastic scattering from nuclei, transverse and longitudinal response in the resonance region, nuclear physics at PEP and 1.6 GeV spectrometer properties. Additional high energy research on electron scattering on 3 H and 3 He and the nuclear structure of 205 Tl and 206 Pb are being conducted at MIT-Bates. Other activities are being carried out at Saclay and research and development for Monte Carlo studies of Hall A spectrometers for CEBAF is being conducted

  1. Maris polarization in neutron-rich nuclei

    Directory of Open Access Journals (Sweden)

    Shubhchintak

    2018-03-01

    Full Text Available We present a theoretical study of the Maris polarization effect and its application in quasi-free reactions to assess information on the structure of exotic nuclei. In particular, we explore the dependence of the polarization effect on neutron excess and neutron-skin thickness. We discuss the uncertainties in the calculations of triple differential cross sections and of analyzing powers due the choices of various nucleon–nucleon interactions and optical potentials and the limitations of the method. Our study implies that polarization variables in (p, 2p reactions in inverse kinematics can be an effective probe of single-particle structure of nuclei in radioactive-beam facilities.

  2. Electron interactions with nuclei. Progress report

    International Nuclear Information System (INIS)

    1986-07-01

    Research includes work at SLAC, Bates, and Saclay research facilities. The high energy program at SLAC concerns inclusive electron scattering from nuclei, electroexcitation of the delta in nuclei, and the design of an electron detection system for the SLAC 1.6 GeV/c magnetic spectrometer. The high energy program at Bates includes quasielastic electron scattering from 1 H, 2 H, 3 He, and 4 He, and electron scattering from 3 H and 3 He. Nuclear structure studies are based on high resolution inelastic electron scattering and include electron scattering from 208 Pb and mercury isotopes, charge densities from low lying states in 86 Sr, and magnetization densities of 205 Tl and 207 Pb. (DWL) 72 refs., 29 figs., 1 tab

  3. Accretion disks in active galactic nuclei

    International Nuclear Information System (INIS)

    Begelman, M.C.

    1985-01-01

    The innermost regions of the central engines in active galactic nuclei are examined, and it is shown how different modes of accretion with angular momentum may account for the diverse manifestations of activity in the nuclei of galaxies. These modes are subsequently compared with the observed properties of quasars, Type I Seyferts, and radio galaxies. It was found that the qualitative features of an accretion flow orbiting a massive black hole depend principally on the ratio of the actual accretion rate to the Eddington accretion rate. For a value of this ratio much less than one, the flow may become an ion torus supported by gas pressure; for a value much greater than one, the flow traps its radiative output and becomes an inefficient radiation torus. At intermediate values, the flow may settle into a thin accretion disk. 62 references

  4. Realistic microscopic level densities for spherical nuclei

    International Nuclear Information System (INIS)

    Cerf, N.

    1994-01-01

    Nuclear level densities play an important role in nuclear reactions such as the formation of the compound nucleus. We develop a microscopic calculation of the level density based on a combinatorial evaluation from a realistic single-particle level scheme. This calculation makes use of a fast Monte Carlo algorithm allowing us to consider large shell model spaces which could not be treated previously in combinatorial approaches. Since our model relies on a microscopic basis, it can be applied to exotic nuclei with more confidence than the commonly used semiphenomenological formuals. An exhaustive comparison of our predicted neutron s-wave resonance spacings with experimental data for a wide range of nuclei is presented

  5. The structure of nuclei far from stability

    International Nuclear Information System (INIS)

    Zganjar, E.F.

    1993-01-01

    Studies on nuclei near Z=82 contributed to the establishment of a new region of nuclear deformation and a new class of nuclear structure at closed shells. A important aspect of this work is the establishment of the connection between low-lying 0 + states in even endash even nuclei and the occurrence of shape coexistence in the odd-mass neighbors (E0 transitions in 185 Pt, shape coexistence in 184 Pt and 187 Au). A new type of picosecond lifetime measurement system capable of measuring the lifetime of states that decay only by internal conversion was developed and applied to the 186,188 Tl decay to determine the lifetime of the 0 2 + and 2 2 + deformed states in 186,188 Hg. A search for the population of superdeformed states in 192 Hg by the radioactive decay of 192 Tl was accomplished by using a prototype internal pair formation spectrometer

  6. Orientation of nuclei excited by polarized neutrons

    International Nuclear Information System (INIS)

    Lifshits, E.P.

    1986-01-01

    Polarization and radiation angular distribution of oriented nuclei in inelastic scattering of polarized neutrons were investigated. Nucleus orientation in the final state was described by polarization density matrix (PDM). If PDM is known, angular distributions, linear and circular polarization of γ-quanta emitted by a nucleus can be determined. Analytical expression for PDM, conditions of its diagonalization in the case of direct nucleus excitation and excitation by the stage of compound nucleus were obtained. Orientation of 12 C nuclei in the excited state 4.439 MeV, 2 + at energy of incident neutrons in the laboratory system from 4.8 MeV (excitation threshold) upt to 9 MeV was calculated as an example. Neutrons in initial state are completely polarized along Z axis. Calculations showed that excitation proceeds mainly by the stage of compound nucleus formation and 12 C nucleus is highly polarized in excited state

  7. Cumulative processes and quark distribution in nuclei

    International Nuclear Information System (INIS)

    Kondratyuk, L.; Shmatikov, M.

    1984-01-01

    Assuming existence of multiquark (mainly 12q) bags in nuclei the spectra of cumulative nucleons and mesons produced in high-energy particle-nucleus collisions are discussed. The exponential form of quark momentum distribution in 12q-bag (agreeing well with the experimental data on lepton-nucleus interactions at large q 2 ) is shown to result in quasi-exponential distribution of cumulative particles over the light-cone variable αsub(B). The dependence of f(αsub(B); psub(perpendicular)) (where psub(perpendicular) is the transverse momentum of the bag) upon psub(perpendicular) is considered. The yields of cumulative resonances as well as effects related to the u- and d-quark distributions in N > Z nuclei being different are dicscussed

  8. Vibrational-rotational model of odd-odd nuclei

    International Nuclear Information System (INIS)

    Afanas'ev, A.V.; Guseva, T.V.; Tamberg, Yu.Ya.

    1988-01-01

    The rotational vibrational (RV) model of odd nuclei is generalized to odd-odd nuclei. The hamiltonian, wave functions and matrix elements of the RV-model of odd-odd nuclei are obtained. The expressions obtained for matrix elements of the RV-model of odd-odd nuclei can be used to study the role of vibrational additions in low-lying two-particle states of odd-odd deformed nuclei. Such calculations permit to study more correctly the residual neutron-proton interaction of valent nucleons with respect to collectivization effects

  9. Role of epithelial-mesenchymal transition (EMT) and fibroblast function in cerium oxide nanoparticles-induced lung fibrosis

    International Nuclear Information System (INIS)

    Ma, Jane; Bishoff, Bridget; Mercer, R.R.; Barger, Mark; Schwegler-Berry, Diane; Castranova, Vincent

    2017-01-01

    The emission of cerium oxide nanoparticles (CeO 2 ) from diesel engines, using cerium compounds as a catalyst to lower the diesel exhaust particles, is a health concern. We have previously shown that CeO 2 induced pulmonary inflammation and lung fibrosis. The objective of the present study was to investigate the modification of fibroblast function and the role of epithelial-mesenchymal transition (EMT) in CeO 2 -induced fibrosis. Male Sprague-Dawley rats were exposed to CeO 2 (0.15 to 7 mg/kg) by a single intratracheal instillation and sacrificed at various times post-exposure. The results show that at 28 days after CeO 2 (3.5 mg/kg) exposure, lung fibrosis was evidenced by increased soluble collagen in bronchoalveolar lavage fluid, elevated hydroxyproline content in lung tissues, and enhanced sirius red staining for collagen in the lung tissue. Lung fibroblasts and alveolar type II (ATII) cells isolated from CeO 2 -exposed rats at 28 days post-exposure demonstrated decreasing proliferation rate when compare to the controls. CeO 2 exposure was cytotoxic and altered cell function as demonstrated by fibroblast apoptosis and aggregation, and ATII cell hypertrophy and hyperplasia with increased surfactant. The presence of stress fibers, expressed as α-smooth muscle actin (SMA), in CeO 2 -exposed fibroblasts and ATII cells was significantly increased compared to the control. Immunohistofluorescence analysis demonstrated co-localization of TGF-β or α-SMA with prosurfactant protein C (SPC)-stained ATII cells. These results demonstrate that CeO 2 exposure affects fibroblast function and induces EMT in ATII cells that play a role in lung fibrosis. These findings suggest potential adverse health effects in response to CeO 2 nanoparticle exposure. - Highlights: • CeO 2 exposure induced lung fibrosis. • CeO 2 were detected in lung tissue, alveolar type II (ATII) cells and fibroblasts. • CeO 2 caused ATII cell hypertrophy and hyperplasia and altered fibroblast function

  10. Role of epithelial-mesenchymal transition (EMT) and fibroblast function in cerium oxide nanoparticles-induced lung fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Jane [Health Effects Laboratory Division, NIOSH, Morgantown, WV (United States); Bishoff, Bridget [Mylan Pharmaceuticals, Morganntown, WV (United States); Mercer, R.R.; Barger, Mark; Schwegler-Berry, Diane [Health Effects Laboratory Division, NIOSH, Morgantown, WV (United States); Castranova, Vincent, E-mail: vcastran@hsc.wvu.edu [School of Pharmacy, West Virginia University, Morgantown, WV (United States)

    2017-05-15

    The emission of cerium oxide nanoparticles (CeO{sub 2}) from diesel engines, using cerium compounds as a catalyst to lower the diesel exhaust particles, is a health concern. We have previously shown that CeO{sub 2} induced pulmonary inflammation and lung fibrosis. The objective of the present study was to investigate the modification of fibroblast function and the role of epithelial-mesenchymal transition (EMT) in CeO{sub 2}-induced fibrosis. Male Sprague-Dawley rats were exposed to CeO{sub 2} (0.15 to 7 mg/kg) by a single intratracheal instillation and sacrificed at various times post-exposure. The results show that at 28 days after CeO{sub 2} (3.5 mg/kg) exposure, lung fibrosis was evidenced by increased soluble collagen in bronchoalveolar lavage fluid, elevated hydroxyproline content in lung tissues, and enhanced sirius red staining for collagen in the lung tissue. Lung fibroblasts and alveolar type II (ATII) cells isolated from CeO{sub 2}-exposed rats at 28 days post-exposure demonstrated decreasing proliferation rate when compare to the controls. CeO{sub 2} exposure was cytotoxic and altered cell function as demonstrated by fibroblast apoptosis and aggregation, and ATII cell hypertrophy and hyperplasia with increased surfactant. The presence of stress fibers, expressed as α-smooth muscle actin (SMA), in CeO{sub 2}-exposed fibroblasts and ATII cells was significantly increased compared to the control. Immunohistofluorescence analysis demonstrated co-localization of TGF-β or α-SMA with prosurfactant protein C (SPC)-stained ATII cells. These results demonstrate that CeO{sub 2} exposure affects fibroblast function and induces EMT in ATII cells that play a role in lung fibrosis. These findings suggest potential adverse health effects in response to CeO{sub 2} nanoparticle exposure. - Highlights: • CeO{sub 2} exposure induced lung fibrosis. • CeO{sub 2} were detected in lung tissue, alveolar type II (ATII) cells and fibroblasts. • CeO{sub 2} caused ATII

  11. How do nuclei really vibrate or rotate

    International Nuclear Information System (INIS)

    Andresen, H.G.; Kunz, J.; Mosel, U.; Mueller, M.; Schuh, A.; Wust, U.

    1983-01-01

    By means of the adiabatic cranking model the properties of the current and velocity fields of nuclear quadrupole vibrations for even-even nuclei in the rare-earth region are investigated. BCS correlated wave functions based on the Nilsson single particle Hamiltonian have been used. The current fields are analyzed in terms of vector spherical harmonics. The realistic microscopic currents show a vortex structure not present in the classical irrotational flow. The microscopic origin of the vortex structure is investigated

  12. AMS with light nuclei at small accelerators

    Science.gov (United States)

    Stan-Sion, C.; Enachescu, M.

    2017-06-01

    AMS applications with lighter nuclei are presented. It will be shown how Carbon-14, Boron-10, Beryllium-10, and Tritium-3 can be used to provide valuable information in forensic science, environmental physics, nuclear pollution, in material science and for diagnose of the plasma confinement in fusion reactors. Small accelerators are reliable, efficient and possess the highest ion beam transmissions that confer high precision in measurements.

  13. Resonant Tidal Disruption in Galactic Nuclei

    OpenAIRE

    Rauch, Kevin P.; Ingalls, Brian

    1997-01-01

    It has recently been shown that the rate of angular momentum relaxation in nearly-Keplerian star clusters is greatly increased by a process termed resonant relaxation (Rauch & Tremaine 1996), who also argued that tidal disruption of stars in galactic nuclei containing massive black holes could be noticeably enhanced by this process. We describe here the results of numerical simulations of resonant tidal disruption which quantitatively test the predictions made by Rauch & Tremaine. The simulat...

  14. Nuclear astrophysics and nuclei far from stability

    International Nuclear Information System (INIS)

    Schatz, H.

    2003-01-01

    Unstable nuclei play a critical role in a number of astrophysical scenarios and are important for our understanding of the origin of the elements. Among the most important scenarios are the r-process (Supernovae), Novae, X-ray bursters, and Superbursters. For these astrophysical events I review the open questions, recent developments in astronomy, and how nuclear physics, in particular experiments with radioactive beams, needs to contribute to find the answers. (orig.)

  15. On the charge distribution of calcium nuclei

    International Nuclear Information System (INIS)

    Traeger, F.

    1981-01-01

    The mean square charge radii and the quadrupole moments of Ca nuclei are discussed in the light of theoretical predictions. The very peculiar dependence of the charge radii on the mass number between double magic 40 Ca and double magic 48 Ca can be ascribed to changes of the nuclear deformation, whereas the volume of the nuclear charge remains constant for all the Ca isotopes. Furthermore, correlations between nuclear charge radii and binding energies are discussed. (orig.)

  16. Complex fragment emission from hot compound nuclei

    International Nuclear Information System (INIS)

    Moretto, L.G.

    1986-03-01

    The experimental evidence for compound nucleus emission of complex fragments at low energies is used to interpret the emission of the same fragments at higher energies. The resulting experimental picture is that of highly excited compound nuclei formed in incomplete fusion processes which decay statistically. In particular, complex fragments appear to be produced mostly through compound nucleus decay. In the appendix a geometric-kinematic theory for incomplete fusion and the associated momentum transfer is outlined. 10 refs., 19 figs

  17. Nuclear moments of radioactive nuclei. Final report

    International Nuclear Information System (INIS)

    Greenlees, G.W.

    1985-01-01

    An unsuccessful attempt was made to study nuclear moments of radioactive nuclear using laser spectroscopy. Although preliminary tests had indicated a sensitivity sufficient to observe signals of fluxes less than one atom/s no resonance fluorescence was detected. Activity measurements showed several hundred nuclei per second were in the beam; therefore it was postulated that, due to the the reactivity of the 126 Ba and sodium used, contaminants were the probable source of negative results. 3 refs., 2 figs

  18. Electromagnetic interactions with nuclei and nucleons

    International Nuclear Information System (INIS)

    Thornton, S.T.; Sealock, R.M.

    1990-01-01

    This report discusses the following topics: general LEGS work; photodisintegration of the deuteron; progress towards other experiments; LEGS instrumentation; major LEGS software projects; NaI detector system; nucleon detector system; waveshifting fibers; EGN prototype detector for CEBAF; photon beam facility at CEBAF; delta electroproduction in nuclei; quasielastic scattering and excitation of the Delta by 4 He(e,e'); and quasielastic scattering at high Q 2

  19. Fission of nuclei far from stability

    International Nuclear Information System (INIS)

    Schmidt, K.H.; Benlliure, J.; Junghans, A.R.

    2000-11-01

    The secondary-beam facility of GSI provided the technical equipment for a new kind of fission experiment. Fission properties of short-lived neutron-deficient nuclei have been investigated in inverse kinematics. The measured element distributions reveal new kinds of systematics on shell structure and even-odd effects and lead to an improved understanding of structure effects in nuclear fission. Prospects for further experimental studies are discussed. (orig.)

  20. Liquid drop parameters for hot nuclei

    International Nuclear Information System (INIS)

    Guet, C.; Strumberger, E.; Brack, M.

    1988-01-01

    Using the semiclassical extended Thomas-FERMI (ETF) density variational method, we derived selfconsistently the liquid drop model (LDM) coefficients for the free energy of hot nuclear systems from a realistic effective interaction (Skyrme SkM*). We expand the temperature (T) dependence of these coefficients up to the second order in T and test their application to the calculation of the fission barriers of the nuclei 208 Pb and 240 Pu

  1. Effective interactions and coupling schemes in nuclei

    International Nuclear Information System (INIS)

    Talmi, I.

    1994-01-01

    Eigenstates of the shell model are obtained by diagonalization of the Hamiltonian submatrix defined by a given shell model subspace. Matrix elements of the effective nuclear interaction can be determined from experiment in a consistent way. This approach was introduced in 1956 with the 38 Cl- 40 K spectra, has been applied in many cases and its latest success is in the s, d shell. This way, general features of the effective interaction have been determined. The T=1 interaction is diagonal in the seniority scheme as clearly demonstrated in proton 1g 9/2 n and 1h 11/2 n configurations and in the description of semimagic nuclei by generalized seniority. Apart from a strong and attractive pairing term, T=1 interactions are repulsive on the average. The T=0 interaction is attractive and is the origin of the central potential well in which nucleons are bound. It breaks seniority in a major way leading to deformed nuclei and rotational spectra. Such an interaction may be approximated by a quadrupole-quadrupole interaction which is the basis of the interacting boson model. Identical nucleons with pairing and quadrupole interactions cannot be models of actual nuclei. Symmetry properties of states with maximum T are very different from those of ground states of actual nuclei. The T=1 interaction between identical nucleons cannot be approximated by pairing and quadrupole interactions. The rich variety of nuclear spectra is due to the competition between seniority conserving T=1 interactions and the T=0 quadrupole interaction between protons and neutrons. (orig.)

  2. High energy collisions of nuclei: experiments

    International Nuclear Information System (INIS)

    Heckman, H.H.

    1977-09-01

    Heavy-ion nuclear reactions with projectile energies up to 2.1 GeV/A are reviewed. The concept of ''rapidity'' is elucidated, and the reactions discussed are divided into sections dealing with target fragmentation, projectile fragmentation, and the intermediate region, with emphasis on the production of light nuclei in high-energy heavy-ion collisions. Target fragmentation experiments using nuclear emulsion and AgCl visual track detectors are also summarized. 18 figures

  3. Chiral bags, skyrmions and quarks in nuclei

    International Nuclear Information System (INIS)

    Rho, M.

    1984-09-01

    Recent developments on an intriguing connection between the quark-bag description of the baryons (nucleons in particular) and the Skyrmion model are discussed in terms of the constraints coming from chiral anomalies. Topics treated are the leaking baryon charge, axial charge and energy density; the role of chiral anomalies; the role of Skyrme's quartic term and the connection to the meson degrees of freedom; and finally some qualitative implications in nuclei. The presentation is purposely descriptive and intuitive instead of mathematically precise

  4. The Skyrmions and quarks in nuclei

    International Nuclear Information System (INIS)

    Rho, M.

    1984-08-01

    It is proposed that the quark-bag description and the Skyrmion description of baryons are related to each other by quantized parameters. Topology (through a chiral anomaly) plays an important role in bridging the fundamental theory of the strong interactions (QCD) to effective theories. Some consequences on the efforts to see quark degrees of freedom in nuclear matter are discussed. It is suggested that at low energies there will be no ''smoking gun'' evidences for quark presence in nuclei

  5. Collective oblate bands in Pb nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Huebel, H; Baldsefen, G; Mehta, D [Bonn Univ. (Germany). Inst. fuer Strahlen- und Kernphysik; and others

    1992-08-01

    The coexistence of different nuclear shapes is a well established phenomenon in the Hg-Pb region, where spherical, oblate, prolate and superdeformed prolate shapes have been observed. In this work, the authors report on several new rotational bands in the normally spherical nuclei {sup 199-201}Pb. Similar structures were found previously in the lighter isotopes {sup 197,198}Pb. 11 refs., 1 tab., 3 figs.

  6. Production and identification of very exotic nuclei

    International Nuclear Information System (INIS)

    Pougheon, F.

    1986-01-01

    New very exotic nuclei have been produced by fragmentation of the projectile at intermediate energy at GANIL. They have been identified through time of flight and ΔE-E measurements after a magnetic separation with the 0 0 LISE spectrometer. New neutron rich isotopes have been identified up to Z = 26 and evidence for the stability of the new series Tz = -5/2 has been shown. These results improve the knowledge of the neutron and proton drip lines

  7. Continuum of active nuclei of galaxies

    International Nuclear Information System (INIS)

    Boisson, C.; Durret, F.

    1987-01-01

    Most of the luminosity of active galactic nuclei (NAG) is radiated in the form of a continuum extending from radio to X-ray energies. It is important to understand the origin of this continuum in order to explain the relative importance of thermal and non-thermal processes in the different classes of NAG. We present here the observational aspect. A detailed study of the mechanisms will be presented by J.L. Masnou [fr

  8. Soft radiative strength in warm nuclei

    International Nuclear Information System (INIS)

    Becker, J A; Bernstein, L A; Garrett, P E; Nelson, R O; Schiller, A; Voinov, A; Agvaanluvsan, U; Algin, E; Belgya, T; Chankova, R; Guttormsen, M; Mitchell, G E; Rekstad, J; Siem, S

    2004-01-01

    Unresolved transitions in the nuclear γ-ray cascade produced in the decay of excited nuclei are best described by statistical concepts: a continuous radiative strength function (RSF) and level density yield mean values of transition matrix elements. Data on the soft (E γ < 3-4 MeV) RSF for transitions between warm states (i.e. states several MeV above the yrast line) have, however, remained elusive

  9. ''Identical'' bands in normally-deformed nuclei

    International Nuclear Information System (INIS)

    Garrett, J.D.; Baktash, C.; Yu, C.H.

    1990-01-01

    Gamma-ray transitions energies in neighboring odd- and even-mass nuclei for normally-deformed nuclear configurations are analyzed in a manner similar to recent analyses for superdeformed states. The moment of inertia is shown to depend on pair correlations and the aligned angular momentum of the odd nucleon. The implications of this analysis for ''identical'' super-deformed bands are discussed. 26 refs., 9 figs

  10. LXA4 actions direct fibroblast function and wound closure

    International Nuclear Information System (INIS)

    Herrera, Bruno S.; Kantarci, Alpdogan; Zarrough, Ahmed; Hasturk, Hatice; Leung, Kai P.; Van Dyke, Thomas E.

    2015-01-01

    Timely resolution of inflammation is crucial for normal wound healing. Resolution of inflammation is an active biological process regulated by specialized lipid mediators including the lipoxins and resolvins. Failure of resolution activity has a major negative impact on wound healing in chronic inflammatory diseases that is manifest as excess fibrosis and scarring. Lipoxins, including Lipoxin A 4 (LXA 4 ), have known anti-fibrotic and anti-scarring properties. The goal of this study was to elucidate the impact of LXA 4 on fibroblast function. Mouse fibroblasts (3T3 Mus musculus Swiss) were cultured for 72 h in the presence of TGF-β1, to induce fibroblast activation. The impact of exogenous TGF-β1 (1 ng/mL) on LXA 4 receptor expression (ALX/FPR2) was determined by flow cytometry. Fibroblast proliferation was measured by bromodeoxyuridine (BrdU) labeling and migration in a “scratch” assay wound model. Expression of α-smooth muscle actin (α-SMA), and collagen types I and III were measured by Western blot. We observed that TGF-β1 up-regulates LXA 4 receptor expression, enhances fibroblast proliferation, migration and scratch wound closure. α-SMA levels and Collagen type I and III deposition were also enhanced. LXA 4 slowed fibroblast migration and scratch wound closure at early time points (24 h), but wound closure was equal to TGF-β1 alone at 48 and 72 h. LXA 4 tended to slow fibroblast proliferation at both concentrations, but had no impact on α-SMA or collagen production by TGF-β1 stimulated fibroblasts. The generalizability of the actions of resolution molecules was examined in experiments repeated with resolvin D2 (RvD2) as the agonist. The activity of RvD2 mimicked the actions of LXA 4 in all assays, through an as yet unidentified receptor. The results suggest that mediators of resolution of inflammation enhance wound healing and limit fibrosis in part by modulating fibroblast function. - Highlights: • TGF-β1 up-regulates LXA 4 receptor (ALX

  11. Preparing nuclei from cells in monolayer cultures suitable for counting and for following synchronized cells through the cell cycle.

    Science.gov (United States)

    Butler, W B

    1984-08-15

    A procedure is described for preparing nuclei from cells in monolayer culture so that they may be counted using an electronic particle counter. It takes only 10 to 15 min, and consists of swelling the cells in hypotonic buffer and then lysing them with the quaternary ammonium salt, ethylhexadecyldimethylammonium bromide. The cells are completely lysed, yielding a suspension of clean single nuclei which is stable, free of debris, and easily counted. The method was developed for a cell line of epithelial origin (MCF-7), which is often difficult to trypsinize to single cells. It works equally well at all cell densities up to and beyond confluence, and has been used with a variety of cells in culture, including 3T3 cells, bovine macrophages, rat mammary epithelial cells, mouse mammary tumor cell lines, and human fibroblasts. The size of the nuclei produced by this procedure is related to their DNA content, and the method is thus suitable for following cultures of synchronized cells through the cell cycle, and for performing differential counts of cells with substantial differences in DNA content.

  12. Double charge exchange of pions on nuclei

    International Nuclear Information System (INIS)

    Dzhibuti, R.I.; Kezerashvili, R.Y.

    1985-01-01

    An analysis is made of the results of experimental and theoretical studies during the last ten years of a unique process: double charge exchange of pions on nuclei. On the one hand, the commissioning of meson factories and the use of new and more accurate experimental methods have led to the accumulation of rich and reliable material for not only light but also medium and heavy nuclei. On the other hand, the development and application of new microscopic theoretical approaches have led to a deepening of our ideas about the mechanism of these exotic reactions at low, intermediate, and high energies. The currently existing methods of theoretical investigation and all possible reaction mechanisms are considered. Particular attention is devoted to double charge exchange of pions on the lightest nuclei, for the theoretical description of which it is possible to use the well-developed methods for investigating few-particle systems. The experimental investigations of double-isobar analog and nonanalog transitions in the reaction of double charge exchange are systematized

  13. The negative-energy sea in nuclei

    International Nuclear Information System (INIS)

    Fox, W.R.

    1989-01-01

    The lowest order quantum corrections in a strongly interacting field theory may be represented by an infinite sum of on-loop diagrams. This sum is known as the one-loop effective action and accounts for the presence of the infinite Dirac sea in the interactions. The Walecka model of nuclear interactions through scalar and vector meson fields has had exceptional success in the mean-field approximation where only the finite density of the valence fermions is considered and the meson operators are replaced by their ground state expectation values. In this work, the lowest order corrections to the Walecka model are considered, first by approximating the effective action by the effective potential (RHA). Next, derivative corrections to the effective potential are included in order to account for the finite size of nuclei. In addition to the linear model, non-linear scalar self-interactions and their effective potential and derivative corrections are examined in nuclei. In general, the systematics for spherical nuclei cannot be improved with positive quartic scalar self-coupling over those without scalar self-interactions

  14. Toward yrast spectroscopy in soft vibrational nuclei

    International Nuclear Information System (INIS)

    Marumori, Toshio; Kuriyama, Atsushi; Sakata, Fumihiko.

    1979-10-01

    In a formally parallel way with that exciting progress has been recently achieved in understanding the yrast spectra of the rotational nuclei in terms of the quasi-particle motion in the rotating frame, an attempt to understand the yrast spectra of the vibrational nuclei in terms of the quasi-particle motion is proposed. The essential idea is to introduce the quasi-particle motion in a generalized vibrating frame, which can be regarded as a rotating frame in the gauge space of ''physical'' phonons where the number of the physical phonons plays the role of the angular momentum. On the basis of a simple fundamental principle called as the ''invariance principle of the Schroedinger equation'', which leads us to the ''maximal decoupling'' between the physical phonon and the intrinsic modes, it is shown that the vibrational frame as well as the physical-phonon-number operator represented by the quasi-particles can be self-consistently determined. A new scope toward the yrast spectroscopy of the vibrational nuclei in terms of the quasi-particle motion is discussed. (author)

  15. Fusion excitation functions involving transitional nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Rehm, K.E.; Jiang, C.L.; Esbensen, H. [and others

    1995-08-01

    Measurements of fusion excitation functions involving transitional nuclei {sup 78}Kr and {sup 100}Mo showed a different behavior at low energies, if compared to measurements with {sup 86}Kr and {sup 92}Mo. This points to a possible influence of nuclear structure on the fusion process. One way to characterize the structure of vibrational nuclei is via their restoring force parameters C{sub 2} which can be calculated from the energy of the lowest 2{sup +} state and the corresponding B(E2) value. A survey of the even-even nuclei between A = 28-150 shows strong variations in C{sub 2} values spanning two orders of magnitude. The lowest values for C{sub 2} are observed for {sup 78}Kr, {sup 104}Ru and {sup 124}Xe followed by {sup 74,76}Ge, {sup 74,76}Se, {sup 100}Mo and {sup 110}Pd. In order to learn more about the influence of {open_quotes}softness{close_quotes} on the sub-barrier fusion enhancement, we measured cross sections for evaporation residue production for the systems {sup 78}Kr + {sup 104}Ru and {sup 78}Kr + {sup 76}Ge with the gas-filled magnet technique. For both systems, fusion excitation functions involving the closed neutron shell nucleus {sup 86}Kr were measured previously. The data are presently being analyzed.

  16. Interaction of slow pions with atomic nuclei

    International Nuclear Information System (INIS)

    Troitskij, M.A.; Tsybul'nikov, A.V.; Chekunaev, N.I.

    1984-01-01

    Interactions of slow pions with atomic nuclei near to pion condensation are investigated. From comparison of experimental data with the theoretical calculation results on the basis of precise microscopic approach not bound with the random phase approximation (RPA) nuclear matter fundamental parameters near a critical point can be found. Optical potential of slow pions in nuclei, πN-scattering amplitudes and lengths, π-atom level isotopic shift, phenomenon of single-nucleon pion absorption by nucleus, phenomenon of nuclear critical opalescence are considered. The results of πN-scattering lengths calculation, sup(40-44)Ca, sup(24-29)Mg, sup(16-18)O π-atom level shift are presented. It is shown that the presence of π-condensate in nuclei can explain the observed suppression of p-wave potential terms. The phenomenon of single-nucleon pion absorption by nucleus is one of direct experiments which permits to reveal the π-condensate. The nuclear opalescence phenomenon is manifested in increase of pion photoproduction reaction cross section for account of nucleus proximity to π-condensation as compared with the calculated in the Fermi-gas model. The suggested method for calculating precondensate phenomena operates the better, the nearer is the system to the condensation threshold whereas the RPA method in this region is inapplicable

  17. Geomagnetically trapped carbon, nitrogen, and oxygen nuclei.

    Science.gov (United States)

    Mogro-Campero, A.

    1972-01-01

    Results of measurements carried out with the University of Chicago nuclear composition telescope on the Ogo 5 satellite, establishing the presence of 13- to 33-MeV/nucleon geomagnetically trapped C and O nuclei, with some evidence for N nuclei. These trapped nuclei were found at L less than or equal to 5 and near the geomagnetic equator. The data cover the period from Mar. 3, 1968, to Dec. 31, 1969. The distribution of CNO flux as a function of L is given. No change in the intensity of the average trapped CNO flux was detected by comparing data for 1968 and 1969. The results reported set a new value for the observed high energy limit of trapping as described by the critical adiabaticity parameter. The penetration of solar flare CNO up to L = 4 was observed twice in 1968, in disagreement with Stormer theory predictions. The effects of these results on some models for the origin of the trapped radiation are discussed.

  18. Electric monopole transitions from low energy excitations in nuclei

    CERN Document Server

    Wood, J L; De Coster, C; Heyde, Kris L G

    1999-01-01

    Electric monopole (E0) properties are studied across the entire nuclear mass surface. Besides an introductory discussion of various model results (shell model, geometric vibrational and rotational models, algebraic models), we point out that many of the largest E0 transition strengths, $\\rho^2$(E0), are associated with shape mixing. We discuss in detail the manifestation of E0 transitions and present extensive data for~: single-closed shell nuclei, vibrational nuclei, well-deformed nuclei, nuclei that exhibit sudden ground-state changes, and nuclei that exhibit shape coexistence and intruder states. We also give attention to light nuclei, odd-A nuclei, and illustrate a suggested relation between $\\rho^2$(E0) and isotopic shifts.

  19. LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer

    Directory of Open Access Journals (Sweden)

    Jean Albrengues

    2014-06-01

    Full Text Available Signaling crosstalk between tumor cells and fibroblasts confers proinvasive properties to the tumor microenvironment. Here, we identify leukemia inhibitory factor (LIF as a tumor promoter that mediates proinvasive activation of stromal fibroblasts independent of alpha-smooth muscle actin (α-SMA expression. We demonstrate that a pulse of transforming growth factor β (TGF-β establishes stable proinvasive fibroblast activation by inducing LIF production in both fibroblasts and tumor cells. In fibroblasts, LIF mediates TGF-β-dependent actomyosin contractility and extracellular matrix remodeling, which results in collective carcinoma cell invasion in vitro and in vivo. Accordingly, carcinomas from multiple origins and melanomas display strong LIF upregulation, which correlates with dense collagen fiber organization, cancer cell collective invasion, and poor clinical outcome. Blockade of JAK activity by Ruxolitinib (JAK inhibitor counteracts fibroblast-dependent carcinoma cell invasion in vitro and in vivo. These findings establish LIF as a proinvasive fibroblast producer independent of α-SMA and may open novel therapeutic perspectives for patients with aggressive primary tumors.

  20. Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts.

    LENUS (Irish Health Repository)

    Burke, J P

    2012-02-01

    BACKGROUND: Fibroblasts play a critical role in intestinal wound healing. Lipopolysaccharide (LPS) is a cell wall component of commensal gut bacteria. The effects of LPS on intestinal fibroblast activation were characterized. METHODS: Expression of the LPS receptor, toll-like receptor (TLR) 4, was assessed in cultured primary human intestinal fibroblasts using flow cytometry and confocal microscopy. Fibroblasts were treated with LPS and\\/or transforming growth factor (TGF) beta1. Nuclear factor kappaB (NFkappaB) pathway activation was assessed by inhibitory kappaBalpha (IkappaBalpha) degradation and NFkappaB promoter activity. Fibroblast contractility was measured using a fibroblast-populated collagen lattice. Smad-7, a negative regulator of TGF-beta1 signalling, and connective tissue growth factor (CTGF) expression were assessed using reverse transcriptase-polymerase chain reaction and western blot. The NFkappaB pathway was inhibited by IkappaBalpha transfection. RESULTS: TLR-4 was present on the surface of intestinal fibroblasts. LPS treatment of fibroblasts induced IkappaBalpha degradation, enhanced NFkappaB promoter activity and increased collagen contraction. Pretreatment with LPS (before TGF-beta1) significantly increased CTGF production relative to treatment with TGF-beta1 alone. LPS reduced whereas TGF-beta1 increased smad-7 expression. Transfection with an IkappaBalpha plasmid enhanced basal smad-7 expression. CONCLUSION: Intestinal fibroblasts express TLR-4 and respond to LPS by activating NFkappaB and inducing collagen contraction. LPS acts in concert with TGF-beta1 to induce CTGF. LPS reduces the expression of the TGF-beta1 inhibitor, smad-7.

  1. Effects of polyhexamethylene guanidine phosphate on human gingival fibroblasts.

    Science.gov (United States)

    Vitt, Anton; Slizen, Veronica; Boström, Elisabeth A; Yucel-Lindberg, Tülay; Kats, Anna; Sugars, Rachael V; Gustafsson, Anders; Buhlin, Kåre

    2017-10-01

    Polyhexamethylene guanidine phosphate (PHMG-P) was compared to chlorhexidine (CHX) in order to determine potential cytotoxic and immune-modulatory effects on human gingival fibroblasts. Cytotoxic effects of PHMG-P and CHX on human gingival fibroblasts were assessed using cell viability assay at various time points and concentrations. The effects of PHMG-P and CHX on the secretion of prostaglandin (PG) E 2 , interleukin (IL)-6, IL-8 and matrix metalloproteinase (MMP)-1 by non-stimulated or IL-1β stimulated fibroblasts were evaluated by enzyme-linked immunosorbent assays. PHMG-P concentration 0.00009% led to the total loss of fibroblast viability within 24 h, whereas inhibition of fibroblast viability by CHX occurred at significantly higher concentrations of 0.0009% (p PHMG-P led to loss of fibroblast viability after 5 min, whilst cells exposed to 0.005% CHX survived 30 min of treatment (p PHMG-P or CHX at concentrations of 0.000045 or 0.0.00009% resulted in significantly decreased PGE 2 , IL-6, IL-8 and MMP-1 levels. PHMG-P or CHX alone did not affect the baseline secretion of PGE 2 , IL-6, IL-8 or MMP-1 by gingival fibroblasts. Cytotoxic effects on gingival fibroblasts were triggered by both PHMG-P and CHX at concentrations below those used in clinical practice. The tested antiseptics did not cause inflammation and reduced IL-1β-induced secretion of inflammatory mediators and collagenase by gingival fibroblasts, which suggests anti-inflammatory properties.

  2. Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer.

    Directory of Open Access Journals (Sweden)

    Julie A Wallace

    Full Text Available Tumor fibroblasts are active partners in tumor progression, but the genes and pathways that mediate this collaboration are ill-defined. Previous work demonstrates that Ets2 function in stromal cells significantly contributes to breast tumor progression. Conditional mouse models were used to study the function of Ets2 in both mammary stromal fibroblasts and epithelial cells. Conditional inactivation of Ets2 in stromal fibroblasts in PyMT and ErbB2 driven tumors significantly reduced tumor growth, however deletion of Ets2 in epithelial cells in the PyMT model had no significant effect. Analysis of gene expression in fibroblasts revealed a tumor- and Ets2-dependent gene signature that was enriched in genes important for ECM remodeling, cell migration, and angiogenesis in both PyMT and ErbB2 driven-tumors. Consistent with these results, PyMT and ErbB2 tumors lacking Ets2 in fibroblasts had fewer functional blood vessels, and Ets2 in fibroblasts elicited changes in gene expression in tumor endothelial cells consistent with this phenotype. An in vivo angiogenesis assay revealed the ability of Ets2 in fibroblasts to promote blood vessel formation in the absence of tumor cells. Importantly, the Ets2-dependent gene expression signatures from both mouse models were able to distinguish human breast tumor stroma from normal stroma, and correlated with patient outcomes in two whole tumor breast cancer data sets. The data reveals a key function for Ets2 in tumor fibroblasts in signaling to endothelial cells to promote tumor angiogenesis. The results highlight the collaborative networks that orchestrate communication between stromal cells and tumor cells, and suggest that targeting tumor fibroblasts may be an effective strategy for developing novel anti-angiogenic therapies.

  3. Matrix metalloproteinase inhibition reduces contraction by dupuytren fibroblasts.

    Science.gov (United States)

    Townley, William A; Cambrey, Alison D; Khaw, Peng T; Grobbelaar, Adriaan O

    2008-11-01

    Dupuytren's disease is a common fibroproliferative condition of the hand characterized by fibrotic lesions (nodules and cords), leading to disability through progressive digital contracture. Although the etiology of the disease is poorly understood, recent evidence suggests that abnormal matrix metalloproteinase (MMP) activity may play a role in cell-mediated collagen contraction and tissue scarring. The aim of this study was to investigate the efficacy of ilomastat, a broad-spectrum MMP inhibitor, in an in vitro model of Dupuytren fibroblast-mediated contraction. Nodule-derived and cord-derived fibroblasts were isolated from Dupuytren patients; carpal ligament-derived fibroblasts acted as control. Stress-release fibroblast-populated collagen lattices (FPCLs) were used as a model of contraction. FPCLs were allowed to develop mechanical stress (48 hours) during treatment with ilomastat (0-100 micromol/L), released, and allowed to contract over a 48-hour period. Contraction was estimated by measuring lattice area compared with untreated cells or treatment with a control peptide. MMP-1, MMP-2, and MT1-MMP levels were assessed by zymography, Western blotting, and enzyme-linked immunosorbent assay. Nodule-derived fibroblasts contracted lattices (69% +/- 2) to a greater extent than did cord-derived (55% +/- 3) or carpal ligament-derived (55% +/- 1) fibroblasts. Exposure to ilomastat led to significant inhibition of lattice contraction by all fibroblasts, although a reduction in lattice contraction by nodule-derived fibroblasts was most prominent (84% +/- 8). In addition, treatment with ilomastat led to a concomitant suppression of MMP-1 and MMP-2 activity, whereas MT1-MMP activity was found to be upregulated. Our results demonstrate that inhibition of MMP activity results in a reduction in extracellular matrix contraction by Dupuytren fibroblasts and suggest that MMP activity may be a critical target in preventing recurrent contracture caused by this disease.

  4. Extracellular matrix organization modulates fibroblast growth and growth factor responsiveness.

    Science.gov (United States)

    Nakagawa, S; Pawelek, P; Grinnell, F

    1989-06-01

    To learn more about the relationship between extracellular matrix organization, cell shape, and cell growth control, we studied DNA synthesis by fibroblasts in collagen gels that were either attached to culture dishes or floating in culture medium during gel contraction. After 4 days of contraction, the collagen density (initially 1.5 mg/ml) reached 22 mg/ml in attached gels and 55 mg/ml in floating gels. After contraction, attached collagen gels were well organized; collagen fibrils were aligned in the plane of cell spreading; and fibroblasts had an elongated, bipolar morphology. Floating collagen gels, however, were unorganized; collagen fibrils were arranged randomly; and fibroblasts had a stellate morphology. DNA synthesis by fibroblasts in contracted collagen gels was suppressed if the gels were floating in medium but not if the gels were attached, and inhibition was independent of the extent of gel contraction. Therefore, growth of fibroblasts in contracted collagen gels could be regulated by differences in extracellular matrix organization and cell shape independently of extracellular matrix density. We also compared the responses of fibroblasts in contracted collagen gels and monolayer culture to peptide growth factors including fibroblast growth factor, platelet-derived growth factor, transforming growth factor-beta, and interleukin 1. Cells in floating collagen gels were generally unresponsive to any of the growth factors. Cells in attached collagen gels and monolayer culture were affected similarly by fibroblast growth factor but not by the others. Our results indicate that extracellular matrix organization influenced not only cell growth, but also fibroblast responsiveness to peptide growth factors.

  5. Alzheimer skin fibroblasts show increased susceptibility to free radicals.

    Science.gov (United States)

    Tesco, G; Latorraca, S; Piersanti, P; Piacentini, S; Amaducci, L; Sorbi, S

    1992-11-01

    We have studied the response to toxic oxygen metabolites of fibroblasts derived from skin biopsies of 5 patients with familial (FAD) and 4 with sporadic (AD) Alzheimer's disease compared with those derived from 4 normal controls. Fibroblasts were damaged by the generation of oxygen metabolites during the enzymatic oxidation of acetaldehyde by 50 munits of xanthine-oxidase (Xo). To quantify cell damage we measured lactate dehydrogenase (LDH) activity in the culture medium and cell viability in fibroblast cultures. We found a significant increase in LDH activity in the FAD vs. controls and also in the AD vs. controls.

  6. Relativistic exotic nuclei as projectile beams. New perspectives of studies on the properties of nuclei

    International Nuclear Information System (INIS)

    Geissel, H.

    1997-03-01

    Examinations of the production cross-sections and the kinematics permitted refinement of model concepts of the peripheral reactions in exotic nuclei at energies from 100 to 1000 A MeV. Due to the strong selectivity and resolution achieved it was possible to discover a large number of novel isotopes at the fragment separator FRS, despite the relatively low projectile beam intensities of the SIS. The two twice magic nuclei found, Ni 78 and Sn 100, are particularly interesting, as they could not be measured so far with other experimental systems. Fission of relativistic uranium ions proved to be a particularly successful process yielding many medium-heavy, neutron-rich nuclei. Insight into the structure of light neutron halos could be improved. The superlarge spatial dimensions of the nuclear halos is discussed. (orig./CB) [de

  7. From heavy nuclei to super-heavy nuclei; Des noyaux lourds aux super-lourds

    Energy Technology Data Exchange (ETDEWEB)

    Theisen, Ch

    2003-01-01

    The existence of super-heavy nuclei has been predicted nearly fifty years ago. Due to the strong coulomb repulsion, the stabilisation of these nuclei is possible only through shell effects. The reasons for this fragile stability, as well as the theoretical predictions concerning the position of the island of stability are presented in the first part of this lecture. In the second part, experiments and experimental techniques which have been used to synthesize or search for super-heavy elements are described. Spectroscopic studies performed in very heavy elements are presented in the following section. We close this lecture with techniques that are currently being developed in order to reach the superheavy island and to study the structure of very-heavy nuclei. (author)

  8. Cultured human foreskin fibroblasts produce a factor that stimulates their growth with properties similar to basic fibroblast growth factor

    International Nuclear Information System (INIS)

    Story, M.T.

    1989-01-01

    To determine if fibroblasts could be a source of fibroblast growth factor (FGF) in tissue, cells were initiated in culture from newborn human foreskin. Fibroblast cell lysates promoted radiolabeled thymidine uptake by cultured quiescent fibroblasts. Seventy-nine percent of the growth-promoting activity of lysates was recovered from heparin-Sepharose. The heparin-binding growth factor reacted on immunoblots with antiserum to human placenta-derived basic FGF and competed with iodinated basic FGF for binding to antiserum to (1-24)bFGF synthetic peptide. To confirm that fibroblasts were the source of the growth factor, cell lysates were prepared from cells incubated with radiolabeled methionine. Heparin affinity purified material was immunoprecipitated with basic FGF antiserum and electrophoresed. Radiolabeled material was detected on gel autoradiographs in the same molecular weight region as authentic iodinated basic FGF. The findings are consistant with the notion that cultured fibroblasts express basic FGF. As these cells also respond to the mitogen, it is possible that the regulation of their growth is under autocrine control. Fibroblasts may be an important source of the growth factor in tissue

  9. Hypermetabolism of Olivary Nuclei in a Patient with Progressive Ataxia and Palatal Tremor

    Directory of Open Access Journals (Sweden)

    Jaana Korpela

    2015-09-01

    Full Text Available Background: The pathophysiology of the movement disorder progressive ataxia with palatal tremor (PAPT is unclear.Case report: A 77-year-old male presented with dysarthria, ataxia, and 1–2 Hz palatal tremor. A diagnosis of probable sporadic PAPT was established. Brain magnetic resonance imaging was normal at the presymptomatic phase but later showed olivary hypertrophy. Brain [18F]-fludeoxyglucose (FDG positron emission tomography (PET showed bilateral hypermetabolism in the olivary nuclei. Discussion: This second reported patient with PAPT and FDG-PET shows that olivary hypertrophy is paralleled with hypermetabolism. The olivary nuclei pathology also appears to be temporally associated with symptom onset.

  10. The dynamics of the nuclei-nuclei interactions at very high energies

    International Nuclear Information System (INIS)

    Blaizot, J.P.

    1988-01-01

    The lectures on the dynamics of nuclei-nuclei interactions at very high energies, presented in the Summer School on Nuclear Physics and Particle Physics (1988), are shown. The equation of state of the hadronic matter is analyzed, by means of simple models, and some orders of magnitude can be asserted. The main characteristics of the high energy hadronic interactions are recalled. The basis of the dynamics of the relativistic fluids are given. Applications of this dynamics in the description of the space-time evolution of a plasma, generated by heavy ions collision, are carried out [fr

  11. Fibroblast growth factor receptor mediates fibroblast-dependent growth in EMMPRIN-depleted head and neck cancer tumor cells.

    Science.gov (United States)

    Liu, Zhiyong; Hartman, Yolanda E; Warram, Jason M; Knowles, Joseph A; Sweeny, Larissa; Zhou, Tong; Rosenthal, Eben L

    2011-08-01

    Head and neck squamous cell carcinoma tumors (HNSCC) contain a dense fibrous stroma which is known to promote tumor growth, although the mechanism of stroma-mediated growth remains unclear. As dysplastic mucosal epithelium progresses to cancer, there is incremental overexpression of extracellular matrix metalloprotease inducer (EMMPRIN) which is associated with tumor growth and metastasis. Here, we present evidence that gain of EMMPRIN expression allows tumor growth to be less dependent on fibroblasts by modulating fibroblast growth factor receptor-2 (FGFR2) signaling. We show that silencing EMMPRIN in FaDu and SCC-5 HNSCC cell lines inhibits cell growth, but when EMMPRIN-silenced tumor cells were cocultured with fibroblasts or inoculated with fibroblasts into severe combined immunodeficient mice, the growth inhibition by silencing EMMPRIN was blunted by the presence of fibroblasts. Coculture experiments showed fibroblast-dependent tumor cell growth occurred via a paracrine signaling. Analysis of tumor gene expression revealed expression of FGFR2 was inversely related to EMMPRIN expression. To determine the role of FGFR2 signaling in EMMPRIN-silenced tumor cells, ligands and inhibitors of FGFR2 were assessed. Both FGF1 and FGF2 enhanced tumor growth in EMMPRIN-silenced cells compared with control vector-transfected cells, whereas inhibition of FGFR2 with blocking antibody or with a synthetic inhibitor (PD173074) inhibited tumor cell growth in fibroblast coculture, suggesting the importance of FGFR2 signaling in fibroblast-mediated tumor growth. Analysis of xenografted tumors revealed that EMMPRIN-silenced tumors had a larger stromal compartment compared with control. Taken together, these results suggest that EMMPRIN acquired during tumor progression promotes fibroblast-independent tumor growth.

  12. Fibroblast growth factor receptor mediates fibroblast-dependent growth in EMMPRIN depleted head and neck cancer tumor cells

    Science.gov (United States)

    Liu, Zhiyong; Hartman, Yolanda E.; Warram, Jason M.; Knowles, Joseph A.; Sweeny, Larrisa; Zhou, Tong; Rosenthal, Eben L.

    2011-01-01

    Head and neck squamous cell carcinoma tumors (HNSCC) contain a dense fibrous stroma which is known to promote tumor growth, although the mechanism of stroma mediated growth remains unclear. As dysplastic mucosal epithelium progresses to cancer there is incremental overexpression of extracellular matrix metalloprotease inducer (EMMPRIN) which is associated with tumor growth and metastasis. Here we present evidence that gain of EMMPRIN expression allows tumor growth to be less dependent on fibroblasts by modulating fibroblast growth factor receptor-2 (FGFR2) signaling. We show that silencing EMMPRIN in FaDu and SCC-5 HNSCC cell lines inhibits cell growth, but when EMMPRIN-silenced tumor cells were co-cultured with fibroblasts or inoculated with fibroblasts into SCID mice, the growth inhibition by silencing EMMPRIN was blunted by the presence of fibroblasts. Co-culture experiments demonstrated fibroblast-dependent tumor cell growth occurred via a paracrine signaling. Analysis of tumor gene expression revealed expression of FGFR2 was inversely related to EMMPRIN expression. To determine the role of FGFR2 signaling in EMMPRIN silenced tumor cells, ligands and inhibitors of FGFR2 were assessed. Both FGF1 and FGF2 enhanced tumor growth in EMMPRIN silenced cells compared to control vector transfected cells, while inhibition of FGFR2 with blocking antibody or with a synthetic inhibitor (PD173074) inhibited tumor cell growth in fibroblast co-culture, suggesting the importance of FGFR2 signaling in fibroblast mediated tumor growth. Analysis of xenografted tumors revealed EMMPRIN silenced tumors had a larger stromal compartment compared to control. Taken together, these results suggest that EMMPRIN acquired during tumor progression promotes fibroblast independent tumor growth. PMID:21665938

  13. Automated Segmentation of Nuclei in Breast Cancer Histopathology Images.

    Science.gov (United States)

    Paramanandam, Maqlin; O'Byrne, Michael; Ghosh, Bidisha; Mammen, Joy John; Manipadam, Marie Therese; Thamburaj, Robinson; Pakrashi, Vikram

    2016-01-01

    The process of Nuclei detection in high-grade breast cancer images is quite challenging in the case of image processing techniques due to certain heterogeneous characteristics of cancer nuclei such as enlarged and irregularly shaped nuclei, highly coarse chromatin marginalized to the nuclei periphery and visible nucleoli. Recent reviews state that existing techniques show appreciable segmentation accuracy on breast histopathology images whose nuclei are dispersed and regular in texture and shape; however, typical cancer nuclei are often clustered and have irregular texture and shape properties. This paper proposes a novel segmentation algorithm for detecting individual nuclei from Hematoxylin and Eosin (H&E) stained breast histopathology images. This detection framework estimates a nuclei saliency map using tensor voting followed by boundary extraction of the nuclei on the saliency map using a Loopy Back Propagation (LBP) algorithm on a Markov Random Field (MRF). The method was tested on both whole-slide images and frames of breast cancer histopathology images. Experimental results demonstrate high segmentation performance with efficient precision, recall and dice-coefficient rates, upon testing high-grade breast cancer images containing several thousand nuclei. In addition to the optimal performance on the highly complex images presented in this paper, this method also gave appreciable results in comparison with two recently published methods-Wienert et al. (2012) and Veta et al. (2013), which were tested using their own datasets.

  14. Automated Segmentation of Nuclei in Breast Cancer Histopathology Images.

    Directory of Open Access Journals (Sweden)

    Maqlin Paramanandam

    Full Text Available The process of Nuclei detection in high-grade breast cancer images is quite challenging in the case of image processing techniques due to certain heterogeneous characteristics of cancer nuclei such as enlarged and irregularly shaped nuclei, highly coarse chromatin marginalized to the nuclei periphery and visible nucleoli. Recent reviews state that existing techniques show appreciable segmentation accuracy on breast histopathology images whose nuclei are dispersed and regular in texture and shape; however, typical cancer nuclei are often clustered and have irregular texture and shape properties. This paper proposes a novel segmentation algorithm for detecting individual nuclei from Hematoxylin and Eosin (H&E stained breast histopathology images. This detection framework estimates a nuclei saliency map using tensor voting followed by boundary extraction of the nuclei on the saliency map using a Loopy Back Propagation (LBP algorithm on a Markov Random Field (MRF. The method was tested on both whole-slide images and frames of breast cancer histopathology images. Experimental results demonstrate high segmentation performance with efficient precision, recall and dice-coefficient rates, upon testing high-grade breast cancer images containing several thousand nuclei. In addition to the optimal performance on the highly complex images presented in this paper, this method also gave appreciable results in comparison with two recently published methods-Wienert et al. (2012 and Veta et al. (2013, which were tested using their own datasets.

  15. Interspecific variation of intracellular localization and postirradiation movement of Ku70-protein in fibroblastic cells

    International Nuclear Information System (INIS)

    Endoh, Daiji; Hayashi, Masanobu; Okui, Toyo; Kawase, Shiro; Kon, Yasushiro

    2003-01-01

    Ku (Ku70 and Ku80) Proteins are known as components of DNA-dependent protein kinase (DNA-PK) and play an important role for DNA repair. We previously reported that more than 70% of Ku proteins were located in cytoplasm of rat cells, the Ku proteins moved into nuclei of normal rat cells after X-irradiation, Ku proteins also moved into nuclei after X-irradiation but were not retained in nucleus of radiosensitive LEC rat cells. While reports have been shown about mechanisms on nuclear localization of Ku proteins, how Ku proteins export from nucleus is poorly understood. Here we show that C-terminal region of Ku70 protein is important for its cytoplasmic localization. When transfected into LEC rat cells, exogenous intact Ku70 (1-609) tagged with enhanced green fluorescent protein (EGFP-Ku70) localized mainly in the cytoplasm, whereas C-terminal-deletion mutant of Ku70 (1-593) tagged with EGFP (EGFP-Ku70D) was mainly localized in the nucleus. After X-irradiation, the endogenous intact EGFP-Ku70 once moved into nucleus, but returned into the cytoplasm. On the other hand, EGFP-Ku70D was retained in nucleus for two hours after X-irradiation. These results suggest that C-terminal region of Ku70 is included in the postirradiation nuclear export. Next, we investigated the intracellular localization of Ku70 proteins and the movement after X-irradiation of fibroblastic cells prepared from some mammalian species. Ku70 proteins were localized in nucleus and the postirradiation-extranuclear transport was not observed in human and African green monkey cells. On the other hand, Ku70 proteins were mainly localized in cytoplasm and moved into nucleus in mouse, Chinese hamster, Golden hamster, cotton rat, squirrel, cat and dog cells. These results may show that alternatively Ku70 protein is localized in the cytoplasm or nucleus depends on species and translocation of cytoplasmic Ku70 into nucleus is a response against low dose irradiation in fibroblasts of rodents, cats and dogs

  16. The radiation response of human dermal fibroblasts

    Science.gov (United States)

    Mitchell, Stephen Andrew

    A clinically reliable predictive assay based on normal-tissue radiosensitivity may lead to improved tumour control through individualised dose prescriptions. In-vitro fibroblast radiosensitivity has been shown, in several studies, to correlate with late radiation morbidity. The aim of this study was to investigate some of the cellular mechanisms underlying the normal-tissue response. In this study, seventeen primary fibroblast strains were established by enzymatic disaggregation of skin biopsies obtained from patients. These comprised seven who experienced acute tissue reactions to radiotherapy, four patients with a normal response and six non-cancer volunteers. An AT cell line was included as a positive control for radiosensitivity. In-vitro radiosensitivity was measured using a clonogenic assay at both high (HDR: 1.6 Gymin-1) and low dose rate (LDR: 0.01 Gymin-1). The radiation parameter HDR SF2 was the most sensitive in discriminating the seven sensitive patients from the remaining ten normal patients (range 0.11-0.19 sensitive patients compared with 0.17-0.34 control patients: puse of an internal control or LDR radiation protocol increased this discrimination. Pulsed-field gel electrophoresis (PFGE) was used to measure the level of initial and residual double-strand breaks following irradiation. No correlation was found between HDR SF2 and initial DNA damage. However, a strong correlation was found between clonogenic survival and both residual DNA damage (measured over 10-70 Gy, allowing 4 h repair, correlation coefficient: 0.90, <0.0001) and the ratio of residual/initial DNA damage, with the sensitive cell lines generally showing a higher level of residual DNA damage. Cell-cycle delays were found in all 18 cell strains in response to 2 Gy irradiation, but were not found to discriminate between sensitive and normal patients. Associated studies found no mutations of the ATM gene in the five radiosensitive patients studied. However, a coding sequence alteration

  17. Effective field theory description of halo nuclei

    Science.gov (United States)

    Hammer, H.-W.; Ji, C.; Phillips, D. R.

    2017-10-01

    Nuclear halos emerge as new degrees of freedom near the neutron and proton driplines. They consist of a core and one or a few nucleons which spend most of their time in the classically-forbidden region outside the range of the interaction. Individual nucleons inside the core are thus unresolved in the halo configuration, and the low-energy effective interactions are short-range forces between the core and the valence nucleons. Similar phenomena occur in clusters of 4He atoms, cold atomic gases near a Feshbach resonance, and some exotic hadrons. In these weakly-bound quantum systems universal scaling laws for s-wave binding emerge that are independent of the details of the interaction. Effective field theory (EFT) exposes these correlations and permits the calculation of non-universal corrections to them due to short-distance effects, as well as the extension of these ideas to systems involving the Coulomb interaction and/or binding in higher angular-momentum channels. Halo nuclei exhibit all these features. Halo EFT, the EFT for halo nuclei, has been used to compute the properties of single-neutron, two-neutron, and single-proton halos of s-wave and p-wave type. This review summarizes these results for halo binding energies, radii, Coulomb dissociation, and radiative capture, as well as the connection of these properties to scattering parameters, thereby elucidating the universal correlations between all these observables. We also discuss how Halo EFT's encoding of the long-distance physics of halo nuclei can be used to check and extend ab initio calculations that include detailed modeling of their short-distance dynamics.

  18. Nuclei at extreme conditions. A relativistic study

    Energy Technology Data Exchange (ETDEWEB)

    Afanasjev, Anatoli [Mississippi State Univ., Mississippi State, MS (United States)

    2014-11-14

    The major goals of the current project were further development of covariant density functional theory (CDFT), better understanding of its features, its application to different nuclear structure and nuclear astrophysics phenomena and training of graduate and undergraduate students. The investigations have proceeded in a number of directions which are discussed in detail in the part “Accomplishments” of this report. We have studied the role of isovector and isoscalar proton-neutron pairings in rotating nuclei; based on available experimental data it was concluded that there are no evidences for the existence of isoscalar proton-neutron pairing. Generalized theoretical approach has been developed for pycnonuclear reaction rates in the crust of neutron stars and interior of white dwarfs. Using this approach, extensive database for considerable number of pycnonuclear reactions involving stable and neutron-rich light nuclei has been created; it can be used in future for the study of various nuclear burning phenomena in different environments. Time-odd mean fields and their manifestations in terminating states, non-rotating and rotating nuclei have been studied in the framework of covariant density functional theory. Contrary to non-relativistic density functional theories these fields, which are important for a proper description of nuclear systems with broken time-reversal symmetry, are uniquely defined in the CDFT framework. Hyperdeformed nuclear shapes (with semi-axis ratio 2.5:1 and larger) have been studied in the Z = 40-58 part of nuclear chart. We strongly believe that such shapes could be studied experimentally in the future with full scale GRETA detector.

  19. Improved Fibroblast Functionalities by Microporous Pattern Fabricated by Microelectromechanical Systems

    Science.gov (United States)

    Wei, Hongbo; Zhao, Lingzhou; Chen, Bangdao; Bai, Shizhu; Zhao, Yimin

    2014-01-01

    Fibroblasts, which play an important role in biological seal formation and maintenance, determine the long-term success of percutaneous implants. In this study, well-defined microporous structures with micropore diameters of 10–60 µm were fabricated by microelectromechanical systems and their influence on the fibroblast functionalities was observed. The results show that the microporous structures with micropore diameters of 10–60 µm did not influence the initial adherent fibroblast number; however, those with diameters of 40 and 50 µm improved the spread, actin stress fiber organization, proliferation and fibronectin secretion of the fibroblasts. The microporous structures with micropore diameters of 40–50 µm may be promising for application in the percutaneous part of an implant. PMID:25054322

  20. Improved Fibroblast Functionalities by Microporous Pattern Fabricated by Microelectromechanical Systems

    Directory of Open Access Journals (Sweden)

    Hongbo Wei

    2014-07-01

    Full Text Available Fibroblasts, which play an important role in biological seal formation and maintenance, determine the long-term success of percutaneous implants. In this study, well-defined microporous structures with micropore diameters of 10–60 µm were fabricated by microelectromechanical systems and their influence on the fibroblast functionalities was observed. The results show that the microporous structures with micropore diameters of 10–60 µm did not influence the initial adherent fibroblast number; however, those with diameters of 40 and 50 µm improved the spread, actin stress fiber organization, proliferation and fibronectin secretion of the fibroblasts. The microporous structures with micropore diameters of 40–50 µm may be promising for application in the percutaneous part of an implant.

  1. Relationship among expression of basic-fibroblast growth factor ...

    African Journals Online (AJOL)

    Relationship among expression of basic-fibroblast growth factor, MTDH/Astrocyte elevated gene-1, adenomatous polyposis coli, matrix metalloproteinase 9,and COX-2 markers with prognostic factors in prostate carcinomas.

  2. Growth of fibroblasts and endothelial cells on wettability gradient surfaces

    NARCIS (Netherlands)

    Ruardy, TG; Moorlag, HE; Schakenraad, JM; VanderMei, HC; Busscher, HJ

    1997-01-01

    The growth, spreading, and shape of human skin fibroblasts (PK 84) and human umbilical cord endothelial cells on dichlorodimethylsilane (DDS) and dimethyloctadecylchlorosilane (DOGS) gradient surfaces were investigated in the presence of serum proteins. Gradient surfaces were prepared on glass using

  3. Factor XIIIa is expressed by fibroblasts in fibrovascular tumors.

    Science.gov (United States)

    Nemeth, A J; Penneys, N S

    1989-10-01

    Factor XIIIa (FXIIIa), a blood and intracellularly produced coagulation factor, has been found in a variety of cell types including fibroblast-like mesenchymal cells, and has been shown to stimulate the proliferation of fibroblasts and some neoplastic cells in vitro. We have already shown that the dendritic fibroblasts composing the fibrous papule contain this factor. We hypothesized that histopathologically similar fibrovascular tumors may also express FXIIIa and, in this report, show that the large stellate fibroblasts found in acquired digital fibrokeratomas, angiofibromas (adenoma sebaceum of Pringle), and oral fibroma (oral fibrous hyperplasia) also express FXIIIa. We postulate that FXIIIa, possibly acting as a growth factor, may be a common denominator in the pathogenesis of these tumors. Another possibility is that these tumors may be the consequence of a local overproduction of FXIIIa in response to an, as yet, unidentified stimulus.

  4. HGF is released from buccal fibroblasts after smokeless tobacco stimulation

    DEFF Research Database (Denmark)

    Dabelsteen, S; Christensen, S; Gron, B

    2005-01-01

    on exposure time and on concentration of the tobacco extract. High concentration increased production of HGF 4-fold. KGF production was doubled when high concentration of tobacco was used, low concentration did not stimulate cells. GM-CSF production was low in both stimulated and non-stimulated cells......To investigate the effect of smokeless tobacco (ST) on (1) HGF, KGF and GM-CSF expression by buccal fibroblasts and (2) on keratinocyte and fibroblast proliferation. Buccal fibroblasts were stimulated with different concentrations of ST extracts in a double dilution from 0.50% w/v to 0.03% w....... Keratinocytes and fibroblasts showed no increase in proliferation after stimulation with increased concentrations of ST. The results suggest that HGF and KGF may play an important role as a paracrine growth factor in epithelial hyperplasia in ST lesions....

  5. Transient expression of acidic fibroblast growth factor in pea (Pisum ...

    African Journals Online (AJOL)

    Yomi

    2012-03-15

    Mar 15, 2012 ... a 100 W, long-wave UV lamp (Black Ray model B-100 AP; Ultra- ... frequency) was used to estimate the treatment efficiency during 15 days post .... Crystal structure of fibroblast growth factor receptor ectodomain bound to.

  6. Sialylation regulates myofibroblast differentiation of human skin fibroblasts.

    Science.gov (United States)

    Sasaki, Norihiko; Itakura, Yoko; Toyoda, Masashi

    2017-04-18

    Fibroblasts are key players in maintaining skin homeostasis and in orchestrating physiological tissue repair and skin regeneration. Dysfunctions in fibroblasts that occur with aging and the senescent process lead to the delayed healing observed in elderly people. The molecular mechanisms leading to fibroblast dysfunction during aging and the senescent process have not yet been clarified. Previously, changes in patterns of glycosylation were observed in fibroblasts in aging and the senescent process, but the effect of these changes on the function of fibroblasts has not been well documented. Here, we investigated whether changes in glycosylation during the process to senescence may have functional effects on fibroblasts. The changes in cell surface glycans on skin fibroblasts during the process to senescence were examined in early-passage (EP) and late-passage (LP) skin fibroblasts by fluorescence-activated cell sorting analysis using lectins. The contributors to the changes in cell surface glycans were examined by real-time polymerase chain reaction or Western blot analysis. The effects of changes in glycosylation on proliferation, migration, induction of cellular senescence, and myofibroblast differentiation induced by transforming growth factor (TGF)-β1 stimulation were examined in EP fibroblasts. The changes in glycosylation were performed by GalNAc-α-O-benzyl or sialidase treatment. A decrease in sialylation of glycoproteins and an increase in sialidase NEU1 were observed in LP fibroblasts. The reduction of sialylation did not have any effect on proliferation, migration, or induction of cellular senescence. On the other hand, myofibroblast differentiation was inhibited by the reduction of sialylation, indicating that sialylation is important for myofibroblast differentiation. The localization of CD44 in lipid rafts, which is required for myofibroblast differentiation, was inhibited by the reduction of sialylation. Furthermore, reduced myofibroblast

  7. RPA ground state correlations in nuclei

    International Nuclear Information System (INIS)

    Lenske, H.

    1990-01-01

    Overcounting in the RPA theory of ground state correlations is shown to be avoided if exact rather than quasiboson commutators are used. Single particle occupation probabilities are formulated in a compact way by the RPA Green function. Calculations with large configuration spaces and realistic interactions are performed with 1p1h RPA and second RPA (SRPA) including 2p2h mixing in excited states. In 41 Ca valence hole states are found to be quenched by about 10% in RPA and up to 18% in SRPA. Contributions from low and high lying excitations and their relation to long and short range correlations in finite nuclei are investigated. (orig.)

  8. Signatures for quark clustering in nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Carlson, C.E. [College of William and Mary, Williamsburg, VA (United States); Lassila, K.E. [Iowa State Univ., Ames, IA (United States)

    1994-04-01

    As a signature for the presence of quark clusters in nuclei, the authors suggest studying backward protons produced by electron scattering off deuterons and suggest a ratio that cancels out much of the detailed properties of deuterons or 6-quark clusters. The test may be viewed as a test that the short range part of the deuteron is still a 2-nucleon system. They make estimates to show how it fails in characteristic and significant ways if the two nucleons at short range coalesce into a kneaded 6-quark cluster.

  9. Algebraic description of intrinsic modes in nuclei

    International Nuclear Information System (INIS)

    Leviatan, A.

    1989-01-01

    We present a procedure for extracting normal modes in algebraic number-conserving systems of interacting bosons relevant for collective states in even-even nuclei. The Hamiltonian is resolved into intrinsic (bandhead related) and collective (in-band related) parts. Shape parameters are introduced through non-spherical boson bases. Intrinsic modes decoupled from the spurious modes are obtained from the intinsic part of the Hamiltonian in the limit of large number of bosons. Intrinsic states are constructed and serve to evaluate electromagnetic transition rates. The method is illustrated for systems with one type of boson as well as with proton-neutron bosons. 28 refs., 1 fig

  10. Modeling a neutron rich nuclei source

    Energy Technology Data Exchange (ETDEWEB)

    Mirea, M.; Bajeat, O.; Clapier, F.; Ibrahim, F.; Mueller, A.C.; Pauwels, N.; Proust, J. [Institut de Physique Nucleaire, IN2P3/CNRS, 91 - Orsay (France); Mirea, M. [Institute of Physics and Nuclear Engineering, Tandem Lab., Bucharest (Romania)

    2000-07-01

    The deuteron break-up process in a suitable converter gives rise to intense neutron beams. A source of neutron rich nuclei based on the neutron induced fission can be realised using these beams. A theoretical optimization of such a facility as a function of the incident deuteron energy is reported. The model used to determine the fission products takes into account the excitation energy of the target nucleus and the evaporation of prompt neutrons. Results are presented in connection with a converter-target specific geometry. (author000.

  11. The Structure of Nuclei Far from Stability

    International Nuclear Information System (INIS)

    Zganjar, E.F.

    1999-01-01

    From among a number of important nuclear structure results that have emerged from our research program during the past few years, two stand out as being of extra significance. These are: (a) the identification of a diabatic coexisting structure in 187 Au which arises solely from differences in proton occupation of adjacent oscillator shells, and (b) the realization of a method for estimating EO strength in nuclei and the resulting prediction that the de-excitation of superdeformed bands may proceed, in some cases, by strong EO transitions

  12. Very high-spin states in nuclei

    International Nuclear Information System (INIS)

    Diamond, R.M.

    1977-03-01

    The continuum γ-ray spectrum following emission in a (HI,xn) reaction consists of a high-energy tail, the statistical cascade, and a lower-energy bump, the yrast cascade, which contains most of the intensity and consists mostly of stretched E2 transitions. Thus, a good approximation to the average angular momentum carried by the γ-ray is 2Nsub(γ). Under favourable conditions, effective moments of inertia can be deduced for states up to the top of the γ-ray cascade. The maximum angular momentum in the cascades is probably limited by α-emission for nuclei with A 150. (Author)

  13. Electromagnetic properties of nuclei at high spins

    International Nuclear Information System (INIS)

    Leander, G.A.

    1986-01-01

    A photon emitted by an excited state is likely to carry away, at most, 1 or 2 h-bar of angular momentum. Therefore, a profusion of photons is needed to deexcite the rapidly rotating states of nuclei formed by heavy-ion reactions. The study of electromagnetic properties has become the primary source of information on nuclear structure at high spins and, also, at the warm temperatures present in the initial stage of the electromagnetic cascade process. The purpose of this paper is a review of the E1, M1, and E2 properties of such highly excited states. 42 refs., 5 figs

  14. Conversion electron spectroscopy in transfermium nuclei

    International Nuclear Information System (INIS)

    Herzberg, R.D.

    2003-01-01

    Conversion electron spectroscopy is an essential tool for the spectroscopy of heavy deformed nuclei. The conversion electron spectrometer SACRED has been used in conjunction with the gas-filled recoil separator RITU to study conversion electron cascades in 254 No. The spectra reveal the ground state rotational bands down to low spin. A detailed analysis of the background seen for 254 No shows that approximately 40% of the decay path goes via excited high K bands which may be built on an isomer. (orig.)

  15. The decay of hot dysprosium nuclei

    International Nuclear Information System (INIS)

    Atac, A.; Rekstad, J.; Guttormsen, M.; Messelt, S.; Ramsoey, T.; Thorsteinsen, T.F.; Loevhoeiden, G.; Roedland, T.

    1987-03-01

    The γ-decay following the 162,163 Dy( 3 He,αxn) reactions with E 3 He =45 MeV has been studied. Non-statistical γ-radiation with energies of E γ ≅1 MeV and ≅2 MeV is found for various residual nuclei. The properties of these γ-ray bumps depend on the number of emitted neutrons and reveal an odd-even mass dependence. New techniques to extract average neutron energies as a function of excitation energy and of the number of emitted neutrons are employed. The deduced neutron energies are consistent with Fermi-gas model predictions

  16. Signatures for quark clustering in nuclei

    International Nuclear Information System (INIS)

    Carlson, C.E.; Lassila, K.E.

    1994-01-01

    As a signature for the presence of quark clusters in nuclei, the authors suggest studying backward protons produced by electron scattering off deuterons and suggest a ratio that cancels out much of the detailed properties of deuterons or 6-quark clusters. The test may be viewed as a test that the short range part of the deuteron is still a 2-nucleon system. They make estimates to show how it fails in characteristic and significant ways if the two nucleons at short range coalesce into a kneaded 6-quark cluster

  17. Kaon interactions with very light nuclei

    International Nuclear Information System (INIS)

    Gibson, B.F.

    1979-01-01

    Low energy kaon interactions (both K and anti K) with very light nuclei are reviewed. Limitations upon present K-nucleus studies due to uncertainties in the K-N amplitudes are emphasized along with promising uses. A brief review of some of the many interesting aspects of anti K-nucleus scattering is given. Comparison of the limited anti K-d and anti K- 4 He elastic data with theory is made. The anti Kd → πΛp reaction is discussed including the possible ΣN virtual bound state. 49 references

  18. Multipole giant resonances in highly excited nuclei

    International Nuclear Information System (INIS)

    Xia Keding; Cai Yanhuang

    1989-01-01

    The isoscalar giant surface resonance and giant dipole resonance in highly excited nuclei are discussed. Excitation energies of the giant modes in 208 Pb are calculated in a simplified model, using the concept of energy wieghted sum rule (EWSR), and the extended Thomas-Fermi approximation at the finite temperature is employed to describe the finite temperature is employed to describe the finite temperature equilibrium state. It is shown that EWSR and the energy of the resonance depend only weakly on temperature in the system. This weak dependence is analysed

  19. New excitation modes in halo nuclei

    International Nuclear Information System (INIS)

    Sagawa, H.

    1992-01-01

    Multipole resonances in exotic neutron-rich nuclei are addressed on the basis of microscopic calculations, i.e., in the framework of the self-consistent H-F + RPA theory. A bunch of resonances with multipoles J π = 0 + , 1 - and 2 + is found near the particle threshold E x ∼ 1 MeV in 10 He having significant portions of the sum rule values and narrow widths. The long tail of the loosely-bound neutrons is the cause of the threshold anomaly of these resonances

  20. Exploring the Physics of Unstable Nuclei

    Science.gov (United States)

    Volya, Alexander

    In this presentation the Continuum Shell Model (CSM) approach is advertised as a powerful theoretical tool for studying physics of unstable nuclei. The approach is illustrated using 17O as an example, which is followed by a brief presentation of the general CSM formalism. The successes of the CSM are highlighted and references are provided throughout the text. As an example, the CSM is applied perturbatively to 20O allowing one to explore the effects of continuum on positions of weakly bound states and low-lying resonances, as well as to discern some effects of threshold discontinuity.

  1. Isovector excitations of N ≠ Z nuclei

    International Nuclear Information System (INIS)

    Passos, E.J.V. de; Menezes, D.P.; Galeao, A.P.N.R.

    1987-09-01

    We show that the method based on the tensor coupling of an appropriate family of isovector excitation operators to the parent isospin multiplet can be used, to advantage, for the correct treatment of the isospin degree of freedom in non isoscalar nuclei. This method is applicable to any isovector excitation operator and for parent states which need not to be of the closed subshells type. As an illustration we apply it to the study of the Gamow-Teller transition strength in 90 Zr. (author) [pt

  2. Collective excitation spectra of transitional even nuclei

    International Nuclear Information System (INIS)

    Quentin, P.; Paris-11 Univ., 91 - Orsay; Deloncle, I.; Libert, J.; Sauvage, J.

    1990-01-01

    This talk is dealing with the nuclear low energy collective motion as described in the context of microscopic versions of the Bohr Hamiltonian. Two different ways of building microscopically Bohr collective Hamiltonians will be sketched; one within the framework of the Generator Coordinate Method, the other using the Adiabatic Time-Dependent Hartree-Fock-Boholyubov approximation. A sample of recent results will be presented which pertains to the description of transitional even nuclei and to the newly revisited phenomenon of superdeformation at low spin

  3. Cosmology and the origin of nuclei

    International Nuclear Information System (INIS)

    Narlikar, Jayant V.

    2010-01-01

    The problem of explaining the origin of all the chemical elements found in the universe is a central problem in astrophysics. In the 1940s Fred Hoyle suggested that they were cooked inside stars, starting with nucleosynthesis of neutrons and protons. In the same decade George Gamow argued that in a hot big bang universe in the first few minutes, the ambient conditions were suitable for formation of nuclei. This paper will review the progress of both these ideas and show that a reasonable compromise between these ideas can be found today. (authors)

  4. Rotating bubble and toroidal nuclei and fragmentation

    International Nuclear Information System (INIS)

    Royer, G.; Haddad, F.; Jouault, B.

    1995-01-01

    The energy of rotating bubble and toroidal nuclei predicted to be formed in central heavy-ion collisions at intermediate energies is calculated within the generalized rotating liquid drop model. The potential barriers standing in these exotic deformation paths are compared with the three dimensional and plane fragmentation barriers. In the toroidal deformation path of the heaviest systems exists a large potential pocket localised below the plane fragmentation barriers. This might allow the temporary survival of heavy nuclear toroids before the final clusterization induced by the surface and proximity tension. (author)

  5. Nuclear Data on Unstable Nuclei for Astrophysics

    International Nuclear Information System (INIS)

    Smith, Michael Scott; Meyer, Richard A; Lingerfelt, Eric; Scott, J.P.; Hix, William Raphael; Ma, Zhanwen; Bardayan, Daniel W.; Blackmon, Jeff C.; Guidry, Mike W.; KOZUB, RAYMOND L.; Chae, Kyung YuK.

    2004-01-01

    Recent measurements with radioactive beams at ORNL's Holifield Radioactive Ion Beam Facility (HRIBF) have prompted the evaluation of a number of reactions involving unstable nuclei needed for stellar explosion studies. We discuss these evaluations, as well as the development of a new computational infrastructure to enable the rapid incorporation of the latest nuclear physics results in astrophysics models. This infrastructure includes programs that simplify the generation of reaction rates, manage rate databases, and visualize reaction rates, all hosted at a new website http://www.nucastrodata.org

  6. Lectures on geometrical properties of nuclei

    International Nuclear Information System (INIS)

    Myers, W.D.

    1975-11-01

    Material concerning the geometrical properties of nuclei is drawn from a number of different sources. The leptodermous nature of nuclear density distributions and potential wells is used to draw together the various geometrical properties of these systems and to provide a unified means for their description. Extensive use is made of expansions of radial properties in terms of the surface diffuseness. A strong case is made for the use of convolution as a geometrical ansatz for generating diffuse surface distributions because of the number of simplifications that arise which are of practical importance. 7 figures

  7. Shell model calculations for exotic nuclei

    International Nuclear Information System (INIS)

    Brown, B.A.; Wildenthal, B.H.

    1991-01-01

    A review of the shell-model approach to understanding the properties of light exotic nuclei is given. Binding energies including p and p-sd model spaces and sd and sd-pf model spaces; cross-shell excitations around 32 Mg, including weak-coupling aspects and mechanisms for lowering the ntw excitations; beta decay properties of neutron-rich sd model, of p-sd and sd-pf model spaces, of proton-rich sd model space; coulomb break-up cross sections are discussed. (G.P.) 76 refs.; 12 figs

  8. Inclusive charge longitudinal response in finite nuclei

    International Nuclear Information System (INIS)

    Alberico, W.M.; Molinari, A.; Czerski, P.; Czerski, P.; Ericson, M.

    1986-03-01

    The experimental dynamic and static longitudinal structure factors of 12 C, 40 Ca and 56 Fe are investigated with a semiclassical RPA theory. The parameters entering into the nuclear mean field (including the nucleon effective mass) and in the isoscalar and isovector particle-hole forces are set by best fitting procedures. Quite reasonable values of these quantities allow a satisfactory account of the experimental data over a wide range of momentum transfers in all the three nuclei. However, to achieve this result, the proton root mean square radius has to be increased over the conventional value of about 13% in 12 C and 22% in 40 Ca and 56 Fe

  9. Sub-Coulomb fusion with halo nuclei

    International Nuclear Information System (INIS)

    Fekou-Youmbi, V.; Sida, J.L.; Alamanos, N.; Auger, F.; Bazin, D.; Borcea, C.; Cabot, C.; Cunsolo, A.; Foti, A.; Gillibert, A.; Lepine, A.; Lewitowicz, M.; Liguori-Neto, R.; Mittig, W.; Pollacco, E.; Roussel-Chomaz, P.; Volant, C.; Yong Feng, Y.

    1995-01-01

    The nuclear structure of halo nuclei may have strong influence on the fusion cross section at sub-barrier energies. The actual theoretical debate is briefly reviewed and sub-barrier fusion calculations for the system 11 Be+ 238 U are presented. An experimental program on sub-barrier fusion for the systems 7,9,10,11 Be+ 238 U is underway at GANIL. First results with 9 Be and 11 Be beams were obtained using the F.U.S.ION detector. Relative fission cross sections are presented. ((orig.))

  10. Exploring the physics of unstable nuclei

    International Nuclear Information System (INIS)

    Volya, Alexander

    2015-01-01

    In this presentation the Continuum Shell Model (CSM) approach is advertised as a powerful theoretical tool for studying physics of unstable nuclei. The approach is illustrated using 17 O as an example, which is followed by a brief presentation of the general CSM formalism. The successes of the CSM are highlighted and references are provided throughout the text. As an example, the CSM is applied perturbatively to 20 O allowing one to explore the effects of continuum on positions of weakly bound states and low-lying resonances, as well as to discern some effects of threshold discontinuity. (author)

  11. Photofissility of heavy nuclei at intermediate energies

    International Nuclear Information System (INIS)

    Deppman, A.; Arruda Neto, J.D.T.; Likhachev, V.P.; Goncalves, M.

    2002-10-01

    We use the recently developed MCMC/MCEF (Multi Collisional Monte Carlo plus Monte Carlo for Evaporation-Fission calculations) model to calculate the photo fissility and the photofission cross section at intermediate energies for the 243 Am and for 209 Bi, and compare them to results obtained for other actinides and to available experimental data. As expected, the results for 243 Am are close to those for 237 Np. The fissility for pre actinide nuclei is nearly one order of magnitude lower than that for the actinides. Both fissility and photofission cross section for 209 Bi are in good agreement with the experimental data. (author)

  12. Giant dipole resonance in hot nuclei

    International Nuclear Information System (INIS)

    Mau, N.V.

    1993-01-01

    Giant resonances built on an excited state of the nucleus at a finite temperature T are studied. The following questions are investigated: how long such collective effects occur in a nucleus when T increases. How the properties of the giant resonances vary when the temperature increases. How the study of giant resonances in hot nuclei can give information on the structure of the nucleus in a highly excited state. The special case of the giant dipole resonance is studied. Some of the experimental results are reviewed and in their theoretical interpretation is discussed. (K.A.). 56 refs., 20 figs., 4 tabs

  13. Modeling a neutron rich nuclei source

    International Nuclear Information System (INIS)

    Mirea, M.; Bajeat, O.; Clapier, F.; Ibrahim, F.; Mueller, A.C.; Pauwels, N.; Proust, J.; Mirea, M.

    2000-01-01

    The deuteron break-up process in a suitable converter gives rise to intense neutron beams. A source of neutron rich nuclei based on the neutron induced fission can be realised using these beams. A theoretical optimization of such a facility as a function of the incident deuteron energy is reported. The model used to determine the fission products takes into account the excitation energy of the target nucleus and the evaporation of prompt neutrons. Results are presented in connection with a converter-target specific geometry. (authors)

  14. Experimental level densities of atomic nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Guttormsen, M.; Bello Garrote, F.L.; Eriksen, T.K.; Giacoppo, F.; Goergen, A.; Hagen, T.W.; Klintefjord, M.; Larsen, A.C.; Nyhus, H.T.; Renstroem, T.; Rose, S.J.; Sahin, E.; Siem, S.; Tornyi, T.G.; Tveten, G.M. [University of Oslo, Department of Physics, Oslo (Norway); Aiche, M.; Ducasse, Q.; Jurado, B. [University of Bordeaux, CENBG, CNRS/IN2P3, B.P. 120, Gradignan (France); Bernstein, L.A.; Bleuel, D.L. [Lawrence Livermore National Laboratory, Livermore, CA (United States); Byun, Y.; Voinov, A. [Ohio University, Department of Physics and Astronomy, Athens, Ohio (United States); Gunsing, F. [CEA Saclay, DSM/Irfu/SPhN, Cedex (France); Lebois, L.; Leniau, B.; Wilson, J. [Institut de Physique Nucleaire d' Orsay, Orsay Cedex (France); Wiedeking, M. [iThemba LABS, P.O. Box 722, Somerset West (South Africa)

    2015-12-15

    It is almost 80 years since Hans Bethe described the level density as a non-interacting gas of protons and neutrons. In all these years, experimental data were interpreted within this picture of a fermionic gas. However, the renewed interest of measuring level density using various techniques calls for a revision of this description. In particular, the wealth of nuclear level densities measured with the Oslo method favors the constant-temperature level density over the Fermi-gas picture. From the basis of experimental data, we demonstrate that nuclei exhibit a constant-temperature level density behavior for all mass regions and at least up to the neutron threshold. (orig.)

  15. Enlargement of thalamic nuclei in Tourette syndrome

    DEFF Research Database (Denmark)

    Miller, Ann M; Bansal, Ravi; Hao, Xuejun

    2010-01-01

    CONTEXT: The basal ganglia and thalamus together connect in parallel closed-loop circuits with the cortex. Previous imaging studies have shown modifications of the basal ganglia and cortical targets in individuals with Tourette syndrome (TS), but less is known regarding the role of the thalamus......-subcortical circuits constitute an anatomical crossroad wherein enlargement of motor nuclei may represent activity-dependent hypertrophy within this component of cortical-subcortical motor circuits, or an adaptive response within a larger putative compensatory system that could thereby directly modulate activity...

  16. Fusion and reactions of exotic nuclei

    Directory of Open Access Journals (Sweden)

    Sánchez-Benítez A.M.

    2011-10-01

    Full Text Available Close to the drip lines, the scattering cross sections of halo nuclei show a different behaviour as compared to the tightly bound projectiles of the stability line. Several experiments carried out in the last decade have been dedicated to investigate the competition between transfer, breakup and fusion channels at energies around and below the Coulomb barrier. The rather complex scenario gives rise to conflicting conclusions concerning the effect of breakup and transfer on reaction dynamics and the sub-barrier fusion process. In this work we discuss recent experimental findings in fusion and reactions of 6He halo nucleus at energies around the Coulomb barrier.

  17. Interactions of 10.6 GeV/n gold nuclei with light and heavy target nuclei in nuclear emulsion

    International Nuclear Information System (INIS)

    Cherry, M.L.; Denes-Jones, P.

    1994-03-01

    We have investigated the particle production and fragmentation of nuclei participating in the interactions of 10.6 GeV/n gold nuclei in nuclear emulsions. A new criteria has been developed to distinguish between the interactions of these gold nuclei with the light (H, C, N, O) and heavy (Ag, Br) target nuclei in the emulsion. This has allowed separate analyzes of the multiplicity and pseudo-rapidity distributions of the singly charged particles emitted in Au-(H, C, N, O) and Au-(Ag, Br) interactions, as well as of the models of breakup of the projectile and target nuclei. The pseudo-rapidity distributions show strong forward asymmetries, particularly for the interactions with the light nuclei. Heavy target nuclei produce a more severe breakup of the projectile gold nucleus than do the lighter targets. A negative correlation between the number of fragments emitted from the target nuclei and the degree of centrality of the collisions has been observed, which can be attributed to the total destruction of the relatively light target nuclei by these very heavy projectile nuclei. (author). 14 refs, 11 figs, 1 tab

  18. Abscisic acid ameliorates the systemic sclerosis fibroblast phenotype in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Bruzzone, Santina, E-mail: santina.bruzzone@unige.it [Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV 1, 16132 Genova (Italy); Centre of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV 9, 16132 Genova (Italy); Advanced Biotechnology Center, Largo Rosanna Benzi 10, 16132 Genova (Italy); Battaglia, Florinda [Centre of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV 9, 16132 Genova (Italy); Mannino, Elena [Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV 1, 16132 Genova (Italy); Parodi, Alessia [Centre of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV 9, 16132 Genova (Italy); Fruscione, Floriana [Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV 1, 16132 Genova (Italy); Advanced Biotechnology Center, Largo Rosanna Benzi 10, 16132 Genova (Italy); Basile, Giovanna [Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV 1, 16132 Genova (Italy); Salis, Annalisa; Sturla, Laura [Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV 1, 16132 Genova (Italy); Centre of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV 9, 16132 Genova (Italy); Negrini, Simone; Kalli, Francesca; Stringara, Silvia [Centre of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV 9, 16132 Genova (Italy); Filaci, Gilberto [Centre of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV 9, 16132 Genova (Italy); Department of Internal Medicine, Viale Benedetto XV 6, 16132 Genova (Italy); and others

    2012-05-25

    Highlights: Black-Right-Pointing-Pointer ABA is an endogenous hormone in humans, regulating different cell responses. Black-Right-Pointing-Pointer ABA reverts some of the functions altered in SSc fibroblasts to a normal phenotype. Black-Right-Pointing-Pointer UV-B irradiation increases ABA content in SSc cultures. Black-Right-Pointing-Pointer SSc fibroblasts could benefit from exposure to ABA and/or to UV-B. -- Abstract: The phytohormone abscisic acid (ABA) has been recently identified as an endogenous hormone in humans, regulating different cell functions, including inflammatory processes, insulin release and glucose uptake. Systemic sclerosis (SSc) is a chronic inflammatory disease resulting in fibrosis of skin and internal organs. In this study, we investigated the effect of exogenous ABA on fibroblasts obtained from healthy subjects and from SSc patients. Migration of control fibroblasts induced by ABA was comparable to that induced by transforming growth factor-{beta} (TGF-{beta}). Conversely, migration toward ABA, but not toward TGF-{beta}, was impaired in SSc fibroblasts. In addition, ABA increased cell proliferation in fibroblasts from SSc patients, but not from healthy subjects. Most importantly, presence of ABA significantly decreased collagen deposition by SSc fibroblasts, at the same time increasing matrix metalloproteinase-1 activity and decreasing the expression level of tissue inhibitor of metalloproteinase (TIMP-1). Thus, exogenously added ABA appeared to revert some of the functions altered in SSc fibroblasts to a normal phenotype. Interestingly, ABA levels in plasma from SSc patients were found to be significantly lower than in healthy subjects. UV-B irradiation induced an almost 3-fold increase in ABA content in SSc cultures. Altogether, these results suggest that the fibrotic skin lesions in SSc patients could benefit from exposure to high(er) ABA levels.

  19. Abscisic acid ameliorates the systemic sclerosis fibroblast phenotype in vitro

    International Nuclear Information System (INIS)

    Bruzzone, Santina; Battaglia, Florinda; Mannino, Elena; Parodi, Alessia; Fruscione, Floriana; Basile, Giovanna; Salis, Annalisa; Sturla, Laura; Negrini, Simone; Kalli, Francesca; Stringara, Silvia; Filaci, Gilberto

    2012-01-01

    Highlights: ► ABA is an endogenous hormone in humans, regulating different cell responses. ► ABA reverts some of the functions altered in SSc fibroblasts to a normal phenotype. ► UV-B irradiation increases ABA content in SSc cultures. ► SSc fibroblasts could benefit from exposure to ABA and/or to UV-B. -- Abstract: The phytohormone abscisic acid (ABA) has been recently identified as an endogenous hormone in humans, regulating different cell functions, including inflammatory processes, insulin release and glucose uptake. Systemic sclerosis (SSc) is a chronic inflammatory disease resulting in fibrosis of skin and internal organs. In this study, we investigated the effect of exogenous ABA on fibroblasts obtained from healthy subjects and from SSc patients. Migration of control fibroblasts induced by ABA was comparable to that induced by transforming growth factor-β (TGF-β). Conversely, migration toward ABA, but not toward TGF-β, was impaired in SSc fibroblasts. In addition, ABA increased cell proliferation in fibroblasts from SSc patients, but not from healthy subjects. Most importantly, presence of ABA significantly decreased collagen deposition by SSc fibroblasts, at the same time increasing matrix metalloproteinase-1 activity and decreasing the expression level of tissue inhibitor of metalloproteinase (TIMP-1). Thus, exogenously added ABA appeared to revert some of the functions altered in SSc fibroblasts to a normal phenotype. Interestingly, ABA levels in plasma from SSc patients were found to be significantly lower than in healthy subjects. UV-B irradiation induced an almost 3-fold increase in ABA content in SSc cultures. Altogether, these results suggest that the fibrotic skin lesions in SSc patients could benefit from exposure to high(er) ABA levels.

  20. Regulating Cancer-Associated Fibroblast Biology in Prostate Cancer

    Science.gov (United States)

    2017-10-01

    AWARD NUMBER: W81XWH-15-1-0512 TITLE: Regulating Cancer-Associated Fibroblast Biology in Prostate Cancer PRINCIPAL INVESTIGATOR: Andrew...SUBTITLE 5a. CONTRACT NUMBER Regulating Cancer-Associated Fibroblast Biology in Prostate Cancer 5b. GRANT NUMBER W81XWH-15-1-0512 5c. PROGRAM...blocked by the addition of Pim inhibitors. These results suggest that the Pim protein kinase can regulate stromal cell biology to modulate epithelial

  1. CARFMAP: A Curated Pathway Map of Cardiac Fibroblasts.

    Directory of Open Access Journals (Sweden)

    Hieu T Nim

    Full Text Available The adult mammalian heart contains multiple cell types that work in unison under tightly regulated conditions to maintain homeostasis. Cardiac fibroblasts are a significant and unique population of non-muscle cells in the heart that have recently gained substantial interest in the cardiac biology community. To better understand this renaissance cell, it is essential to systematically survey what has been known in the literature about the cellular and molecular processes involved. We have built CARFMAP (http://visionet.erc.monash.edu.au/CARFMAP, an interactive cardiac fibroblast pathway map derived from the biomedical literature using a software-assisted manual data collection approach. CARFMAP is an information-rich interactive tool that enables cardiac biologists to explore the large body of literature in various creative ways. There is surprisingly little overlap between the cardiac fibroblast pathway map, a foreskin fibroblast pathway map, and a whole mouse organism signalling pathway map from the REACTOME database. Among the use cases of CARFMAP is a common task in our cardiac biology laboratory of identifying new genes that are (1 relevant to cardiac literature, and (2 differentially regulated in high-throughput assays. From the expression profiles of mouse cardiac and tail fibroblasts, we employed CARFMAP to characterise cardiac fibroblast pathways. Using CARFMAP in conjunction with transcriptomic data, we generated a stringent list of six genes that would not have been singled out using bioinformatics analyses alone. Experimental validation showed that five genes (Mmp3, Il6, Edn1, Pdgfc and Fgf10 are differentially regulated in the cardiac fibroblast. CARFMAP is a powerful tool for systems analyses of cardiac fibroblasts, facilitating systems-level cardiovascular research.

  2. CARFMAP: A Curated Pathway Map of Cardiac Fibroblasts.

    Science.gov (United States)

    Nim, Hieu T; Furtado, Milena B; Costa, Mauro W; Kitano, Hiroaki; Rosenthal, Nadia A; Boyd, Sarah E

    2015-01-01

    The adult mammalian heart contains multiple cell types that work in unison under tightly regulated conditions to maintain homeostasis. Cardiac fibroblasts are a significant and unique population of non-muscle cells in the heart that have recently gained substantial interest in the cardiac biology community. To better understand this renaissance cell, it is essential to systematically survey what has been known in the literature about the cellular and molecular processes involved. We have built CARFMAP (http://visionet.erc.monash.edu.au/CARFMAP), an interactive cardiac fibroblast pathway map derived from the biomedical literature using a software-assisted manual data collection approach. CARFMAP is an information-rich interactive tool that enables cardiac biologists to explore the large body of literature in various creative ways. There is surprisingly little overlap between the cardiac fibroblast pathway map, a foreskin fibroblast pathway map, and a whole mouse organism signalling pathway map from the REACTOME database. Among the use cases of CARFMAP is a common task in our cardiac biology laboratory of identifying new genes that are (1) relevant to cardiac literature, and (2) differentially regulated in high-throughput assays. From the expression profiles of mouse cardiac and tail fibroblasts, we employed CARFMAP to characterise cardiac fibroblast pathways. Using CARFMAP in conjunction with transcriptomic data, we generated a stringent list of six genes that would not have been singled out using bioinformatics analyses alone. Experimental validation showed that five genes (Mmp3, Il6, Edn1, Pdgfc and Fgf10) are differentially regulated in the cardiac fibroblast. CARFMAP is a powerful tool for systems analyses of cardiac fibroblasts, facilitating systems-level cardiovascular research.

  3. Fibroblast Growth Factor Signaling in Metabolic Regulation.

    Science.gov (United States)

    Nies, Vera J M; Sancar, Gencer; Liu, Weilin; van Zutphen, Tim; Struik, Dicky; Yu, Ruth T; Atkins, Annette R; Evans, Ronald M; Jonker, Johan W; Downes, Michael Robert

    2015-01-01

    The prevalence of obesity is a growing health problem. Obesity is strongly associated with several comorbidities, such as non-alcoholic fatty liver disease, certain cancers, insulin resistance, and type 2 diabetes, which all reduce life expectancy and life quality. Several drugs have been put forward in order to treat these diseases, but many of them have detrimental side effects. The unexpected role of the family of fibroblast growth factors in the regulation of energy metabolism provides new approaches to the treatment of metabolic diseases and offers a valuable tool to gain more insight into metabolic regulation. The known beneficial effects of FGF19 and FGF21 on metabolism, together with recently discovered similar effects of FGF1 suggest that FGFs and their derivatives carry great potential as novel therapeutics to treat metabolic conditions. To facilitate the development of new therapies with improved targeting and minimal side effects, a better understanding of the molecular mechanism of action of FGFs is needed. In this review, we will discuss what is currently known about the physiological roles of FGF signaling in tissues important for metabolic homeostasis. In addition, we will discuss current concepts regarding their pharmacological properties and effector tissues in the context of metabolic disease. Also, the recent progress in the development of FGF variants will be reviewed. Our goal is to provide a comprehensive overview of the current concepts and consensuses regarding FGF signaling in metabolic health and disease and to provide starting points for the development of FGF-based therapies against metabolic conditions.

  4. Electron-microscope study of cloud and fog nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Ogiwara, S; Okita, T

    1952-01-01

    Droplets of clouds on a mountain and of fog in an urban area were captured and the form, nature and size of their nuclei were studied by means of an electron-microscope and by a chamber of constant humidity. These nuclei have similar form and nature to the hygroscopic particles in haze and to the artificially produced combustion particles. No sea-salt nuclei were found in our observations, therefore, sea-spray appears to be an insignificant source of condensation nuclei. It was found that both the cloud and the fog nuclei originated in combustion products which were the mixture of hygroscopic and non-hygroscopic substances, and that the greater part of the nuclei did not contain pure sulfuric acid.

  5. Symmetry energy, unstable nuclei and neutron star crusts

    Energy Technology Data Exchange (ETDEWEB)

    Iida, Kei [Kochi University, Department of Natural Science, Kochi (Japan); RIKEN Nishina Center, Saitama (Japan); Oyamatsu, Kazuhiro [RIKEN Nishina Center, Saitama (Japan); Aichi Shukutoku University, Department of Human Informatics, Aichi (Japan)

    2014-02-15

    The phenomenological approach to inhomogeneous nuclear matter is useful to describe fundamental properties of atomic nuclei and neutron star crusts in terms of the equation of state of uniform nuclear matter. We review a series of researches that we have developed by following this approach. We start with more than 200 equations of state that are consistent with empirical masses and charge radii of stable nuclei and then apply them to describe matter radii and masses of unstable nuclei, proton elastic scattering and total reaction cross sections off unstable nuclei, and nuclei in neutron star crusts including nuclear pasta. We finally discuss the possibility of constraining the density dependence of the symmetry energy from experiments on unstable nuclei and even observations of quasi-periodic oscillations in giant flares of soft gamma-ray repeaters. (orig.)

  6. On the occurrence of nuclei in mature sieve elements.

    Science.gov (United States)

    Event, R F; Davis, J D; Tucker, C M; Alfieri, F J

    1970-12-01

    The secondary phloem of 3 species of the Taxodiaceae and 13 species of woody dicotyledons was examined for the occurrence of nuclei in mature sieve elements. Nuclei were found in all mature sieve cells of Metasequoia glyptostroboides, Sequoia sempervirens and Taxodium distichum, and in some mature sieve-tube members in 12 of the 13 species of woody dicotyledons. Except for nuclei of sieve cells undergoing cessation of function, the nuclei in mature sieve cells of M. glyptostroboides, S. sempervirens and T. distichum were normal in appearance. The occurrence and morphology of nuclei in mature sieve-tube members of the woody dicotyledons were quite variable. Only 3 species, Robinia pseudoacacia, Ulmus americana and Vitis riparia, contained some mature sieve elements with apparently normal nuclei.

  7. Nuclear-physical investigations with oriented nuclei and polarized neutrons

    International Nuclear Information System (INIS)

    Alfimenkov, V.P.; Pikel'ner, L.B.; Sharapov, Eh.I.

    1980-01-01

    Several experiments with oriented nuclei and polarized neutrons are considered, as well as some methods of polarization of neutrons and nuclei. Experiments on the study of spin dependence of neutron cross sections for fissionable and nonfissionable nuclei interaction of polarized neutrons with polarized nuclei as well as measurement of magnetic momenta of compound-states of rare-earth nuclei. Described are some investigations with thermal neutrons: study on spin dependence of neutron scattering length with nuclei and gamma radiation of neutron radiation capture. Difficulties of production of high-intensive polarized neutron beams and construction of oriented targets are noted. Neutron polarization by transmission of them through a polarized proton target is the most universal method (out of existing methods) in the energy range under consideration [ru

  8. A Study of volumetric variations of basal nuclei in the normal human brain by magnetic resonance imaging.

    Science.gov (United States)

    Elkattan, Amal; Mahdy, Amal; Eltomey, Mohamed; Ismail, Radwa

    2017-03-01

    Knowledge of the effects of healthy aging on brain structures is necessary to identify abnormal changes due to diseases. Many studies have demonstrated age-related volume changes in the brain using MRI. 60 healthy individuals who had normal MRI aged from 20 years to 80 years were examined and classified into three groups: Group I: 21 persons; nine males and 12 females aging between 20-39 years old. Group II: 22 persons; 11 males and 11 females aging between 40-59 years old. Group III: 17 persons; eight males and nine females aging between 60-80 years old. Volumetric analysis was done to evaluate the effect of age, gender and hemispheric difference in the caudate and putamen by the slicer 4.3.3.1 software using 3D T1-weighted images. Data were analyzed by student's unpaired t test, ANOVA and regression analysis. The volumes of the measured and corrected caudate nuclei and putamen significantly decreased with aging in males. There was a statistically insignificant relation between the age and the volume of the measured caudate nuclei and putamen in females but there was a statistically significant relation between the age and the corrected caudate nuclei and putamen. There was no significant difference on the caudate and putamen volumes between males and females. There was no significant difference between the right and left caudate nuclei volumes. There was a leftward asymmetry in the putamen volumes. The results can be considered as a base to track individual changes with time (aging and CNS diseases). Clin. Anat. 30:175-182, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  9. Brain nuclei in actively courting red-sided garter snakes: a paradigm of neural trimorphism.

    Science.gov (United States)

    Krohmer, Randolph W; DeMarchi, Geno A; Baleckaitis, Daniel D; Lutterschmidt, Deborah I; Mason, Robert T

    2011-03-28

    During the breeding season, two distinct male phenotypes are exhibited by red-sided garter snakes (Thamnophis sirtalis parietalis), with courtship behavior being directed not only toward females, but also toward a sub-population of males called she-males. She-males are morphologically identical to other males except for a circulating androgen level three times that of normal males and their ability to produce a female-like pheromone. As in other vertebrates, limbic nuclei in the red-sided garter snake brain are involved in the control of sexual behaviors. For example, an intact anterior hypothalamus pre-optic area (AHPOA) is essential for the initiation and maintenance of reproduction. To determine if brain morphology varies among the three behavioral phenotypes (i.e., males, she-males, and females) during the breeding season, we examined the volume, cell size and cell density of the AHPOA as well as a control region, the external nucleus of the optic tract (ENOT). We used Luxol Fast Blue and Ziehl's Fuchsin to visualize neurons and glial cells, respectively. No significant differences were observed among the three behavioral phenotypes in the volume, cell size or density in the control region. In contrast, the volume, cell size and density of the AHPOA of she-males were significantly greater than those of both male and female snakes. While the volume of the AHPOA was significantly greater in females compared to males, no differences were observed in cell size or density. These differences in brain morphology suggest a possible underlying mechanism for phenotypic-specific behavioral patterns. Copyright © 2010 Elsevier Inc. All rights reserved.

  10. Senescent phenotypes of skin fibroblasts from patients with Tangier disease

    International Nuclear Information System (INIS)

    Matsuura, Fumihiko; Hirano, Ken-ichi; Ikegami, Chiaki; Sandoval, Jose C.; Oku, Hiroyuki; Yuasa-Kawase, Miyako; Tsubakio-Yamamoto, Kazumi; Koseki, Masahiro; Masuda, Daisaku; Tsujii, Ken-ichi; Ishigami, Masato; Nishida, Makoto; Shimomura, Iichiro; Hori, Masatsugu; Yamashita, Shizuya

    2007-01-01

    Tangier disease (TD) is characterized by a deficiency of high density lipoprotein (HDL) in plasma and patients with TD have an increased risk for coronary artery disease (CAD). Recently, we reported that fibroblasts from TD exhibited large and flattened morphology, which is often observed in senescent cells. On the other hand, data have accumulated to show the relationship between cellular senescence and development of atherosclerotic CAD. The aim of the present study was to investigate whether TD fibroblasts exhibited cellular senescence. The proliferation of TD fibroblasts was gradually decreased at population doubling level (PDL) ∼10 compared with control cells. TD cells practically ceased proliferation at PDL ∼30. DNA synthesis was markedly decreased in TD fibroblasts. TD cells exhibited a higher positive rate for senescence-associated β-galactosidase (SA-β-gal), which is one of the biomarkers of cellular senescence in vitro. These data showed that TD cells reached cellular senescence at an earlier PDL compared with controls. Although, there was no difference in the telomere length of fibroblasts between TD and controls at the earlier passage (PDL 6), the telomere length of TD cells was shorter than that of controls at the late passage (PDL 25). Taken together, the current study demonstrates that the late-passaged TD fibroblasts showed senescent phenotype in vitro, which might be related to the increased cardiovascular manifestations in TD patients

  11. [Isolation, purification and primary culture of adult mouse cardiac fibroblasts].

    Science.gov (United States)

    Li, Rujun; Gong, Kaizheng; Zhang, Zhengang

    2017-01-01

    Objective To establish a method for primary culture of adult mouse cardiac fibroblasts. Methods Myocardial tissues from adult mice were digested with 1 g/L trypsin and 0.8 g/L collagenase IV by oscillating water bath for a short time repeatedly. Cardiac fibroblasts and myocardial cells were isolated with differential adhesion method. Immunofluorescence staining was used to assess the purity of cardiac fibroblasts. The cell morphology was observed under an inverted phase contrast microscope. The proliferation of cardiac fibroblasts was analyzed by growth curve and CCK-8 assay. The Smad2/3 phosphorylation induced by TGF-β1 was detected by Western blotting. Results After 90 minutes of differential adhesion, adherent fibroblasts formed spherical cell mass and after 3 days, cells were spindle-shaped and proliferated rapidly. Cells were confluent after 5 days and the growth curve presented nearly "S" shape. The positive expression rate of vimentin was 95%. CCK-8 assay showed that the optimal cell proliferating activity was found from day 3 to day 5. The level of phosphorylated Smad2/3 obviously increased at the second passage induced by TGF-β1. Conclusion This method is economical and stable to isolate cardiac fibroblasts with high activity and high purity from adult mice.

  12. Atmospheric particles acting as ice forming nuclei in different size ranges and cloud condensation nuclei measurements

    International Nuclear Information System (INIS)

    Santachiara, G.; Di Matteo, L.; Belosi, F.; Prodi, F.

    2009-01-01

    Measurements of ice nuclei (I N) in different size classes of aerosol P M1, P M2.5, PM10, and total suspended particles (Tsp) were performed at a rural site (S.Pietro Capofiume, in the Po Valley, Italy). Simultaneous measurements of particle number concentrations were also made with a condensation nucleus counter (CN C-TSI), along with particle concentration in different size classes starting from diameter d > 0.3 μm (Optical Spectrometer Grimm, Mod.1.108). No correlation is observed between I N and the particle number concentration measured with the condensation nuclei counter, and there is only a weak correlation with the particle concentration measured using the optical counter, thus confirming the contribution of the accumulation and coarse aerosol fraction. A positive correlation is observed between supersaturation with respect to ice and water values and ice nuclei number concentration, and an exponential dependence of I N on temperature is found. In addition, cloud concentration nuclei (C CN) were measured. The present measurements reveal a diurnal trend, with lower values at about midday and higher ones during the night, a similar trend between C CN and the relative humidity, and opposite to the mixing layer height.

  13. Precision measurement of the mass difference between light nuclei and anti-nuclei

    CERN Document Server

    Adam, Jaroslav; Aggarwal, Madan Mohan; Aglieri Rinella, Gianluca; Agnello, Michelangelo; Agrawal, Neelima; Ahammed, Zubayer; Ahmed, Ijaz; Ahn, Sang Un; Aimo, Ilaria; Aiola, Salvatore; Ajaz, Muhammad; Akindinov, Alexander; Alam, Sk Noor; Aleksandrov, Dmitry; Alessandro, Bruno; Alexandre, Didier; Alfaro Molina, Jose Ruben; Alici, Andrea; Alkin, Anton; Alme, Johan; Alt, Torsten; Altinpinar, Sedat; Altsybeev, Igor; Alves Garcia Prado, Caio; Andrei, Cristian; Andronic, Anton; Anguelov, Venelin; Anielski, Jonas; Anticic, Tome; Antinori, Federico; Antonioli, Pietro; Aphecetche, Laurent Bernard; Appelshaeuser, Harald; Arcelli, Silvia; Armesto Perez, Nestor; Arnaldi, Roberta; Aronsson, Tomas; Arsene, Ionut Cristian; Arslandok, Mesut; Augustinus, Andre; Averbeck, Ralf Peter; Azmi, Mohd Danish; Bach, Matthias Jakob; Badala, Angela; Baek, Yong Wook; Bagnasco, Stefano; Bailhache, Raphaelle Marie; Bala, Renu; Baldisseri, Alberto; Ball, Markus; Baltasar Dos Santos Pedrosa, Fernando; Baral, Rama Chandra; Barbano, Anastasia Maria; Barbera, Roberto; Barile, Francesco; Barnafoldi, Gergely Gabor; Barnby, Lee Stuart; Ramillien Barret, Valerie; Bartalini, Paolo; Bartke, Jerzy Gustaw; Bartsch, Esther; Basile, Maurizio; Bastid, Nicole; Basu, Sumit; Bathen, Bastian; Batigne, Guillaume; Batista Camejo, Arianna; Batyunya, Boris; Batzing, Paul Christoph; Bearden, Ian Gardner; Beck, Hans; Bedda, Cristina; Behera, Nirbhay Kumar; Belikov, Iouri; Bellini, Francesca; Bello Martinez, Hector; Bellwied, Rene; Belmont Iii, Ronald John; Belmont Moreno, Ernesto; Belyaev, Vladimir; Bencedi, Gyula; Beole, Stefania; Berceanu, Ionela; Bercuci, Alexandru; Berdnikov, Yaroslav; Berenyi, Daniel; Bertens, Redmer Alexander; Berzano, Dario; Betev, Latchezar; Bhasin, Anju; Bhat, Inayat Rasool; Bhati, Ashok Kumar; Bhattacharjee, Buddhadeb; Bhom, Jihyun; Bianchi, Livio; Bianchi, Nicola; Bianchin, Chiara; Bielcik, Jaroslav; Bielcikova, Jana; Bilandzic, Ante; Biswas, Saikat; Bjelogrlic, Sandro; Blanco, Fernando; Blau, Dmitry; Blume, Christoph; Bock, Friederike; Bogdanov, Alexey; Boggild, Hans; Boldizsar, Laszlo; Bombara, Marek; Book, Julian Heinz; Borel, Herve; Borissov, Alexander; Borri, Marcello; Bossu, Francesco; Botje, Michiel; Botta, Elena; Boettger, Stefan; Braun-Munzinger, Peter; Bregant, Marco; Breitner, Timo Gunther; Broker, Theo Alexander; Browning, Tyler Allen; Broz, Michal; Brucken, Erik Jens; Bruna, Elena; Bruno, Giuseppe Eugenio; Budnikov, Dmitry; Buesching, Henner; Bufalino, Stefania; Buncic, Predrag; Busch, Oliver; Buthelezi, Edith Zinhle; Buxton, Jesse Thomas; Caffarri, Davide; Cai, Xu; Caines, Helen Louise; Calero Diaz, Liliet; Caliva, Alberto; Calvo Villar, Ernesto; Camerini, Paolo; Carena, Francesco; Carena, Wisla; Castillo Castellanos, Javier Ernesto; Castro, Andrew John; Casula, Ester Anna Rita; Cavicchioli, Costanza; Ceballos Sanchez, Cesar; Cepila, Jan; Cerello, Piergiorgio; Chang, Beomsu; Chapeland, Sylvain; Chartier, Marielle; Charvet, Jean-Luc Fernand; Chattopadhyay, Subhasis; Chattopadhyay, Sukalyan; Chelnokov, Volodymyr; Cherney, Michael Gerard; Cheshkov, Cvetan Valeriev; Cheynis, Brigitte; Chibante Barroso, Vasco Miguel; Dobrigkeit Chinellato, David; Chochula, Peter; Choi, Kyungeon; Chojnacki, Marek; Choudhury, Subikash; Christakoglou, Panagiotis; Christensen, Christian Holm; Christiansen, Peter; Chujo, Tatsuya; Chung, Suh-Urk; Cicalo, Corrado; Cifarelli, Luisa; Cindolo, Federico; Cleymans, Jean Willy Andre; Colamaria, Fabio Filippo; Colella, Domenico; Collu, Alberto; Colocci, Manuel; Conesa Balbastre, Gustavo; Conesa Del Valle, Zaida; Connors, Megan Elizabeth; Contreras Nuno, Jesus Guillermo; Cormier, Thomas Michael; Corrales Morales, Yasser; Cortes Maldonado, Ismael; Cortese, Pietro; Cosentino, Mauro Rogerio; Costa, Filippo; Crochet, Philippe; Cruz Albino, Rigoberto; Cuautle Flores, Eleazar; Cunqueiro Mendez, Leticia; Dahms, Torsten; Dainese, Andrea; Danu, Andrea; Das, Debasish; Das, Indranil; Das, Supriya; Dash, Ajay Kumar; Dash, Sadhana; De, Sudipan; De Caro, Annalisa; De Cataldo, Giacinto; De Cuveland, Jan; De Falco, Alessandro; De Gruttola, Daniele; De Marco, Nora; De Pasquale, Salvatore; Deisting, Alexander; Deloff, Andrzej; Denes, Ervin Sandor; D'Erasmo, Ginevra; Di Bari, Domenico; Di Mauro, Antonio; Di Nezza, Pasquale; Diaz Corchero, Miguel Angel; Dietel, Thomas; Dillenseger, Pascal; Divia, Roberto; Djuvsland, Oeystein; Dobrin, Alexandru Florin; Dobrowolski, Tadeusz Antoni; Domenicis Gimenez, Diogenes; Donigus, Benjamin; Dordic, Olja; Dubey, Anand Kumar; Dubla, Andrea; Ducroux, Laurent; Dupieux, Pascal; Ehlers Iii, Raymond James; Elia, Domenico; Engel, Heiko; Erazmus, Barbara Ewa; Erhardt, Filip; Eschweiler, Dominic; Espagnon, Bruno; Estienne, Magali Danielle; Esumi, Shinichi; Evans, David; Evdokimov, Sergey; Eyyubova, Gyulnara; Fabbietti, Laura; Fabris, Daniela; Faivre, Julien; Fantoni, Alessandra; Fasel, Markus; Feldkamp, Linus; Felea, Daniel; Feliciello, Alessandro; Feofilov, Grigorii; Ferencei, Jozef; Fernandez Tellez, Arturo; Gonzalez Ferreiro, Elena; Ferretti, Alessandro; Festanti, Andrea; Figiel, Jan; Araujo Silva Figueredo, Marcel; Filchagin, Sergey; Finogeev, Dmitry; Fionda, Fiorella; Fiore, Enrichetta Maria; Fleck, Martin Gabriel; Floris, Michele; Foertsch, Siegfried Valentin; Foka, Panagiota; Fokin, Sergey; Fragiacomo, Enrico; Francescon, Andrea; Frankenfeld, Ulrich Michael; Fuchs, Ulrich; Furget, Christophe; Furs, Artur; Fusco Girard, Mario; Gaardhoeje, Jens Joergen; Gagliardi, Martino; Gago Medina, Alberto Martin; Gallio, Mauro; Gangadharan, Dhevan Raja; Ganoti, Paraskevi; Gao, Chaosong; Garabatos Cuadrado, Jose; Garcia-Solis, Edmundo Javier; Gargiulo, Corrado; Gasik, Piotr Jan; Germain, Marie; Gheata, Andrei George; Gheata, Mihaela; Ghosh, Premomoy; Ghosh, Sanjay Kumar; Gianotti, Paola; Giubellino, Paolo; Giubilato, Piero; Gladysz-Dziadus, Ewa; Glassel, Peter; Gomez Ramirez, Andres; Gonzalez Zamora, Pedro; Gorbunov, Sergey; Gorlich, Lidia Maria; Gotovac, Sven; Grabski, Varlen; Graczykowski, Lukasz Kamil; Grelli, Alessandro; Grigoras, Alina Gabriela; Grigoras, Costin; Grigoryev, Vladislav; Grigoryan, Ara; Grigoryan, Smbat; Grynyov, Borys; Grion, Nevio; Grosse-Oetringhaus, Jan Fiete; Grossiord, Jean-Yves; Grosso, Raffaele; Guber, Fedor; Guernane, Rachid; Guerzoni, Barbara; Gulbrandsen, Kristjan Herlache; Gulkanyan, Hrant; Gunji, Taku; Gupta, Anik; Gupta, Ramni; Haake, Rudiger; Haaland, Oystein Senneset; Hadjidakis, Cynthia Marie; Haiduc, Maria; Hamagaki, Hideki; Hamar, Gergoe; Hanratty, Luke David; Hansen, Alexander; Harris, John William; Hartmann, Helvi; Harton, Austin Vincent; Hatzifotiadou, Despina; Hayashi, Shinichi; Heckel, Stefan Thomas; Heide, Markus Ansgar; Helstrup, Haavard; Herghelegiu, Andrei Ionut; Herrera Corral, Gerardo Antonio; Hess, Benjamin Andreas; Hetland, Kristin Fanebust; Hilden, Timo Eero; Hillemanns, Hartmut; Hippolyte, Boris; Hristov, Peter Zahariev; Huang, Meidana; Humanic, Thomas; Hussain, Nur; Hussain, Tahir; Hutter, Dirk; Hwang, Dae Sung; Ilkaev, Radiy; Ilkiv, Iryna; Inaba, Motoi; Ionita, Costin; Ippolitov, Mikhail; Irfan, Muhammad; Ivanov, Marian; Ivanov, Vladimir; Izucheev, Vladimir; Jacobs, Peter Martin; Jahnke, Cristiane; Jang, Haeng Jin; Janik, Malgorzata Anna; Pahula Hewage, Sandun; Jena, Chitrasen; Jena, Satyajit; Jimenez Bustamante, Raul Tonatiuh; Jones, Peter Graham; Jung, Hyungtaik; Jusko, Anton; Kalinak, Peter; Kalweit, Alexander Philipp; Kamin, Jason Adrian; Kang, Ju Hwan; Kaplin, Vladimir; Kar, Somnath; Karasu Uysal, Ayben; Karavichev, Oleg; Karavicheva, Tatiana; Karpechev, Evgeny; Kebschull, Udo Wolfgang; Keidel, Ralf; Keijdener, Darius Laurens; Keil, Markus; Khan, Kamal; Khan, Mohammed Mohisin; Khan, Palash; Khan, Shuaib Ahmad; Khanzadeev, Alexei; Kharlov, Yury; Kileng, Bjarte; Kim, Beomkyu; Kim, Do Won; Kim, Dong Jo; Kim, Hyeonjoong; Kim, Jinsook; Kim, Mimae; Kim, Minwoo; Kim, Se Yong; Kim, Taesoo; Kirsch, Stefan; Kisel, Ivan; Kiselev, Sergey; Kisiel, Adam Ryszard; Kiss, Gabor; Klay, Jennifer Lynn; Klein, Carsten; Klein, Jochen; Klein-Boesing, Christian; Kluge, Alexander; Knichel, Michael Linus; Knospe, Anders Garritt; Kobayashi, Taiyo; Kobdaj, Chinorat; Kofarago, Monika; Kohler, Markus Konrad; Kollegger, Thorsten; Kolozhvari, Anatoly; Kondratev, Valerii; Kondratyeva, Natalia; Kondratyuk, Evgeny; Konevskikh, Artem; Kouzinopoulos, Charalampos; Kovalenko, Vladimir; Kowalski, Marek; Kox, Serge; Koyithatta Meethaleveedu, Greeshma; Kral, Jiri; Kralik, Ivan; Kravcakova, Adela; Krelina, Michal; Kretz, Matthias; Krivda, Marian; Krizek, Filip; Kryshen, Evgeny; Krzewicki, Mikolaj; Kubera, Andrew Michael; Kucera, Vit; Kucheryaev, Yury; Kugathasan, Thanushan; Kuhn, Christian Claude; Kuijer, Paulus Gerardus; Kulakov, Igor; Kumar, Jitendra; Lokesh, Kumar; Kurashvili, Podist; Kurepin, Alexander; Kurepin, Alexey; Kuryakin, Alexey; Kushpil, Svetlana; Kweon, Min Jung; Kwon, Youngil; La Pointe, Sarah Louise; La Rocca, Paola; Lagana Fernandes, Caio; Lakomov, Igor; Langoy, Rune; Lara Martinez, Camilo Ernesto; Lardeux, Antoine Xavier; Lattuca, Alessandra; Laudi, Elisa; Lea, Ramona; Leardini, Lucia; Lee, Graham Richard; Lee, Seongjoo; Legrand, Iosif; Lehnert, Joerg Walter; Lemmon, Roy Crawford; Lenti, Vito; Leogrande, Emilia; Leon Monzon, Ildefonso; Leoncino, Marco; Levai, Peter; Li, Shuang; Li, Xiaomei; Lien, Jorgen Andre; Lietava, Roman; Lindal, Svein; Lindenstruth, Volker; Lippmann, Christian; Lisa, Michael Annan; Ljunggren, Hans Martin; Lodato, Davide Francesco; Lonne, Per-Ivar; Loggins, Vera Renee; Loginov, Vitaly; Loizides, Constantinos; Lopez, Xavier Bernard; Lopez Torres, Ernesto; Lowe, Andrew John; Lu, Xianguo; Luettig, Philipp Johannes; Lunardon, Marcello; Luparello, Grazia; Maevskaya, Alla; Mager, Magnus; Mahajan, Sanjay; Mahmood, Sohail Musa; Maire, Antonin; Majka, Richard Daniel; Malaev, Mikhail; Maldonado Cervantes, Ivonne Alicia; Malinina, Liudmila; Mal'Kevich, Dmitry; Malzacher, Peter; Mamonov, Alexander; Manceau, Loic Henri Antoine; Manko, Vladislav; Manso, Franck; Manzari, Vito; Marchisone, Massimiliano; Mares, Jiri; Margagliotti, Giacomo Vito; Margotti, Anselmo; Margutti, Jacopo; Marin, Ana Maria; Markert, Christina; Marquard, Marco; Martashvili, Irakli; Martin, Nicole Alice; Martin Blanco, Javier; Martinengo, Paolo; Martinez Hernandez, Mario Ivan; Martinez-Garcia, Gines; Martinez Pedreira, Miguel; Martynov, Yevgen; Mas, Alexis Jean-Michel; Masciocchi, Silvia; Masera, Massimo; Masoni, Alberto; Massacrier, Laure Marie; Mastroserio, Annalisa; Matyja, Adam Tomasz; Mayer, Christoph; Mazer, Joel Anthony; Mazzoni, Alessandra Maria; Mcdonald, Daniel; Meddi, Franco; Menchaca-Rocha, Arturo Alejandro; Meninno, Elisa; Mercado-Perez, Jorge; Meres, Michal; Miake, Yasuo; Mieskolainen, Matti Mikael; Mikhaylov, Konstantin; Milano, Leonardo; Milosevic, Jovan; Minervini, Lazzaro Manlio; Mischke, Andre; Mishra, Aditya Nath; Miskowiec, Dariusz Czeslaw; Mitra, Jubin; Mitu, Ciprian Mihai; Mohammadi, Naghmeh; Mohanty, Bedangadas; Molnar, Levente; Montano Zetina, Luis Manuel; Montes Prado, Esther; Morando, Maurizio; Moreira De Godoy, Denise Aparecida; Moretto, Sandra; Morreale, Astrid; Morsch, Andreas; Muccifora, Valeria; Mudnic, Eugen; Muhlheim, Daniel Michael; Muhuri, Sanjib; Mukherjee, Maitreyee; Muller, Hans; Mulligan, James Declan; Gameiro Munhoz, Marcelo; Murray, Sean; Musa, Luciano; Musinsky, Jan; Nandi, Basanta Kumar; Nania, Rosario; Nappi, Eugenio; Naru, Muhammad Umair; Nattrass, Christine; Nayak, Kishora; Nayak, Tapan Kumar; Nazarenko, Sergey; Nedosekin, Alexander; Nellen, Lukas; Ng, Fabian; Nicassio, Maria; Niculescu, Mihai; Niedziela, Jeremi; Nielsen, Borge Svane; Nikolaev, Sergey; Nikulin, Sergey; Nikulin, Vladimir; Noferini, Francesco; Nomokonov, Petr; Nooren, Gerardus; Norman, Jaime; Nyanin, Alexander; Nystrand, Joakim Ingemar; Oeschler, Helmut Oskar; Oh, Saehanseul; Oh, Sun Kun; Ohlson, Alice Elisabeth; Okatan, Ali; Okubo, Tsubasa; Olah, Laszlo; Oleniacz, Janusz; Oliveira Da Silva, Antonio Carlos; Oliver, Michael Henry; Onderwaater, Jacobus; Oppedisano, Chiara; Ortiz Velasquez, Antonio; Oskarsson, Anders Nils Erik; Otwinowski, Jacek Tomasz; Oyama, Ken; Ozdemir, Mahmut; Pachmayer, Yvonne Chiara; Pagano, Paola; Paic, Guy; Pajares Vales, Carlos; Pal, Susanta Kumar; Pan, Jinjin; Pandey, Ashutosh Kumar; Pant, Divyash; Papikyan, Vardanush; Pappalardo, Giuseppe; Pareek, Pooja; Park, Woojin; Parmar, Sonia; Passfeld, Annika; Paticchio, Vincenzo; Paul, Biswarup; Pawlak, Tomasz Jan; Peitzmann, Thomas; Pereira Da Costa, Hugo Denis Antonio; Pereira De Oliveira Filho, Elienos; Peresunko, Dmitry Yurevich; Perez Lara, Carlos Eugenio; Peskov, Vladimir; Pestov, Yury; Petracek, Vojtech; Petrov, Viacheslav; Petrovici, Mihai; Petta, Catia; Piano, Stefano; Pikna, Miroslav; Pillot, Philippe; Pinazza, Ombretta; Pinsky, Lawrence; Piyarathna, Danthasinghe; Ploskon, Mateusz Andrzej; Planinic, Mirko; Pluta, Jan Marian; Pochybova, Sona; Podesta Lerma, Pedro Luis Manuel; Poghosyan, Martin; Polishchuk, Boris; Poljak, Nikola; Poonsawat, Wanchaloem; Pop, Amalia; Porteboeuf, Sarah Julie; Porter, R Jefferson; Pospisil, Jan; Prasad, Sidharth Kumar; Preghenella, Roberto; Prino, Francesco; Pruneau, Claude Andre; Pshenichnov, Igor; Puccio, Maximiliano; Puddu, Giovanna; Pujahari, Prabhat Ranjan; Punin, Valery; Putschke, Jorn Henning; Qvigstad, Henrik; Rachevski, Alexandre; Raha, Sibaji; Rajput, Sonia; Rak, Jan; Rakotozafindrabe, Andry Malala; Ramello, Luciano; Raniwala, Rashmi; Raniwala, Sudhir; Rasanen, Sami Sakari; Rascanu, Bogdan Theodor; Rathee, Deepika; Razazi, Vahedeh; Read, Kenneth Francis; Real, Jean-Sebastien; Redlich, Krzysztof; Reed, Rosi Jan; Rehman, Attiq Ur; Reichelt, Patrick Simon; Reicher, Martijn; Reidt, Felix; Ren, Xiaowen; Renfordt, Rainer Arno Ernst; Reolon, Anna Rita; Reshetin, Andrey; Rettig, Felix Vincenz; Revol, Jean-Pierre; Reygers, Klaus Johannes; Riabov, Viktor; Ricci, Renato Angelo; Richert, Tuva Ora Herenui; Richter, Matthias Rudolph; Riedler, Petra; Riegler, Werner; Riggi, Francesco; Ristea, Catalin-Lucian; Rivetti, Angelo; Rocco, Elena; Rodriguez Cahuantzi, Mario; Rodriguez Manso, Alis; Roeed, Ketil; Rogochaya, Elena; Rohr, David Michael; 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Zyzak, Maksym

    2015-08-17

    The measurement of the mass differences for systems bound by the strong force has reached a very high precision with protons and anti-protons. The extension of such measurement from (anti-)baryons to (anti-)nuclei allows one to probe any difference in the interactions between nucleons and anti-nucleons encoded in the (anti-)nuclei masses. This force is a remnant of the underlying strong interaction among quarks and gluons and can be described by effective theories, but cannot yet be directly derived from quantum chromodynamics. Here we report a measurement of the difference between the ratios of the mass and charge of deuterons (d) and anti-deuterons ($\\bar{d}$), and $^{3}{\\rm He}$ and $^3\\overline{\\rm He}$ nuclei carried out with the ALICE (A Large Ion Collider Experiment) detector in Pb-Pb collisions at a centre-of-mass energy per nucleon pair of 2.76 TeV. Our direct measurement of the mass-over-charge differences confirm CPT invariance to an unprecedented precision in the sector of light nuclei. This funda...

  14. Deformation and shape coexistence in medium mass nuclei

    International Nuclear Information System (INIS)

    Meyer, R.A.

    1985-01-01

    Emerging evidence for deformed structures in medium mass nuclei is reviewed. Included in this review are both nuclei that are ground state symmetric rotors and vibrational nuclei where there are deformed structures at excited energies (shape coexistence). For the first time, Nilsson configurations in odd-odd nuclei within the region of deformation are identified. Shape coexistence in nuclei that abut the medium mass region of deformation is also examined. Recent establishment of a four-particle, four-hole intruder band in the double subshell closure nucleus 96 Zr 56 is presented and its relation to the nuclear vibron model is discussed. Special attention is given to the N=59 nuclei where new data have led to the reanalysis of 97 Sr and 99 Zr and the presence of the [404 9/2] hole intruder state as isomers in these nuclei. The low energy levels of the N=59 nuclei from Z=38 to 50 are compared with recent quadrupole-phonon model calculations that can describe their transition from near-rotational to single closed shell nuclei. The odd-odd N=59 nuclei are discussed in the context of coexisting shape isomers based on the (p[303 5/2]n[404 9/2])2 - configuration. Ongoing in-beam (t,p conversion-electron) multiparameter measurements that have led to the determination of monopole matrix elements for even-even 42 Mo nuclei are presented, and these are compared with initial estimates using IBA-2 calculations that allow mixing of normal and cross subshell excitations. Lastly, evidence for the neutron-proton 3 S 1 force's influence on the level structure of these nuclei is discussed within the context of recent quadrupole-phonon model calculations. (Auth.)

  15. Systematics of light nuclei in a relativistic model

    International Nuclear Information System (INIS)

    Price, C.E.

    1988-01-01

    The results of relativistic mean field calculations for non-spherical nuclei are presented and discussed. The need for non-linear scalar meson self-couplings in order to describe the properties of s-d shell nuclei is emphasized along with the importance of self-consistency in calculations of magnetic moments of odd-mass nuclei. 16 refs., 3 figs., 2 tabs

  16. Exotic nuclei and radioactive beams; Noyaux exotiques et faisceaux radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Chomaz, P.

    1996-12-31

    The Nuclei called exotic are all the nuclei that it is necessary to recreate in laboratory to study them. Their life time is too short -in relation to earth age- for it remains enough on earth. The researchers are going to have at their s disposal at GANIL (Caen) with the S.P.I.R.A.L. project, exotic nuclei beams and will study new kinds of nuclear reactions to better understand the atom nucleus. (N.C.). 2 refs., 9 figs.

  17. Projected shell model description of N = 114 superdeformed isotone nuclei

    International Nuclear Information System (INIS)

    Guo, R S; Chen, L M; Chou, C H

    2006-01-01

    A systematic description of the yrast superdeformed (SD) bands in N 114, Z = 80-84 isotone nuclei using the projected shell model is presented. The calculated γ-ray energies, moment of inertia and M1 transitions are compared with the data for which spin is assigned. Excellent agreement with the available data for all isotones is obtained. The calculated electromagnetic properties provide a microscopic understanding of those measured nuclei. Some predictions in superdeformed nuclei are also discussed

  18. Male pattern baldness

    Science.gov (United States)

    Alopecia in men; Baldness - male; Hair loss in men; Androgenetic alopecia ... Male pattern baldness is related to your genes and male sex hormones. It usually follows a pattern of receding hairline and ...

  19. Genital sores - male

    Science.gov (United States)

    Sores - male genitals; Ulcers - male genitals ... A common cause of male genital sores are infections that are spread through sexual contact, such as: Genital herpes (small, painful blisters filled with clear ...

  20. Birth, life and death of hot nuclei

    International Nuclear Information System (INIS)

    Suraud, E.; Tamain, B.; Gregoire, C.

    1989-01-01

    Intermediate energy heavy-ions (10-100 MeV/u) are the most powerful tool to study hot nuclear matter properties. In this paper we give a review of experimental and theoretical works which support this statement. The first challenge is to achieve hot nuclei formation. The second one is to study their properties. The formation step is governed by the relative influence of nucleon-nucleon collisions and mean field effects. Fundamental quantities such as excited matter decay time, thermalization time, relaxation time for collective modes are of major importance and are compared with typical collision times. It appears that semi-classical theories are able to give a reasonable description of the collision and that they are a good guide for defining further experiments. We show how it has been possible to experimentally establish that very hot equilibrated nuclei are really formed. Their decay properties are not basically different from decay properties at lower bombarding energy. However specific channels are open: in that sense, we take stock of the multifragmentation process. Moreover, compression effects may be an important feature of this energy range. Future studies will involve heavier projectiles around 30-50 MeV/u. They will be the best probe for hot and compressed nuclear matter studies