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Sample records for malaya

  1. Cultural Aspects of Language Imposition in Malaya, Singapore, and Indonesia.

    Science.gov (United States)

    Bickley, Verner C.

    1973-01-01

    This paper distinguishes Bahasa Malaysia (Malaysian language) and Bahasa Indonesia (Indonesian language) according to type and function and summarizes their development as the national languages of Malaya, Singapore, and Indonesia. It presents a short, historical account of the spread, through religious and educational activities, of the English…

  2. Three new species of Asclepiadaceae from peninsular Malaya

    NARCIS (Netherlands)

    Rintz, R.E.

    1979-01-01

    Recent intensive exploration in peninsular Malaya for members of the Asclepiadaceae has resulted in the collection of many rare species and new records of species formerly known only from Thailand. In addition, the following 3 new species were also collected. I wish to express my thanks to Mrs.

  3. Explaining Success and Failure: Counterinsurgency in Malaya and India

    Science.gov (United States)

    2010-12-01

    Journal of Peasant Studies 33, no. 1 (January 2006): 89. 24 Praveen Swami, “For a Review of Counterinsurgency Doctrine,”The Hindu, April 13, 2010...Malaya in the 1950s are used as a guide in formulating counterinsurgency doctrine against the Maoist-type of insurgency in India as per Praveen ...relief camps. The 39 Praveen Swami, “For a Review of Counterinsurgency Doctrine,” The Hindu, April 13, 2010, http://www.thehindu.com/opinion/lead

  4. Islamic Reform in Malaya: The Contribution of Shaykh Tahir Jalaluddin

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    Hafiz Zakariya

    2005-06-01

    Full Text Available Abstract: Reformation of religion does not entail changing the very teaching of Islam or the introduction of un-Islamic elements into Islam. Rather reformation of religion is a return to the original sources of Islam as practiced during the period of the Prophet (SAS and early generations of muslims, unadulterated by the practices and beliefs that contravened Islam. This salafī reformist discourse, as the historical evidence shows, was adopted by Shaykh Tahir in his attempts to reform Islam in colonial Malaya.

  5. 1948 AND THE COLD WAR IN MALAYA: SAMPLINGS OF MALAY REACTIONS

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    Abdul Rahman Haji Ismail

    2009-01-01

    Full Text Available This paper is a preliminary report of an on-going research on the reactions of the Malays in Malaya to the coming of the Cold War to the region, with particular reference to the importance of the year 1948. For the majority of the Malays, the Cold War was most popularly associated with the Emergency, which British authorities had declared in the effort to quell the armed uprising mounted by the MCP. The vast majority of Malays in Malaya were not interested in the on-going Cold War between the Western bloc led by the United States on the side the Eastern bloc led by the Soviet Union on the other. The preoccupations of the Malays during the immediate post-Pacific War period was nationalism and the concomitant effort to gain independence for Malaya from Britain. In particular, they had been rather anxious that the Malays, who were the native of the land, were not robbed of the custodianship over Malaya and political privileges of the Malays in independent Malaya. Consumed with these issues, the Malays had little interests in external affairs. It was perhaps the lack of Malay support that foredoomed the fate of communism in Malaya.

  6. Environmental Effects of Driving Automobiles in the University of Malaya Campus: A Pilot Study

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    S.Y. Kong

    2009-12-01

    Full Text Available With the increase of human population there has been an evident increase in per capita automobile use and ownership, significantly to a point that almost every urban university campus faces serious challenges from the heavy traffic movement as well as the associated parking shortages. Multiple factors, including lack of land for new parking lots, high cost of building parking structures and the desire to preserve the air quality and campus green spaces are leading many educational institutions towards a new vision based upon expanded transit access, better bicycle and pedestrian facilities and financial incentives for students and staff to drive less. (Toor and Havlick, 2004 This is in stark contrast to the traditional approach to campus transportation planning of the University of Malaya (UM, Kuala Lumpur, Malaysia that allows students, staff and visitors to drive in the campus. The objective of this study is to investigate the related issues and environmental impact of allowing automobile driving in the campus. Studies will also be done to analyse the relationship between university campus planning and traffic condition. Air quality and noise pollution data of 3 selected sites in the campus will be recorded. Subsequently, the air pollutant index and noise pollution level will be identified and data analyses will be done on the data samples. Simultaneously, a survey questionnaire will be conducted to gauge the student’s attitude and degree of awareness with air and noise pollution in the campus. This pilot study reveals that the increasing use of automobiles within the campus has a negative impact on local environment and the quality of life in campus

  7. Descriptive epidemiology of colorectal cancer in University Malaya Medical Centre, 2001 to 2010.

    Science.gov (United States)

    Magaji, Bello Arkilla; Moy, Foong Ming; Roslani, April Camilla; Law, Chee Wei

    2014-01-01

    Colorectal cancer is the second most frequent cancer in Malaysia. Nevertheless, there is little information on treatment and outcomes nationally. We aimed to determine the demographic, clinical and treatment characteristics of colorectal cancer patients treated at the University Malaya Medical Centre (UMMC) as part of a larger project on survival and quality of life outcomes. Medical records of 1,212 patients undergoing treatment in UMMC between January 2001 and December 2010 were reviewed. A retrospective-prospective cohort study design was used. Research tools included the National Cancer Patient Registration form. Statistical analysis included means, standard deviations (SD), proportions, chi square, t-test/ ANOVA. P-value significance was set at 0.05. The male: female ratio was 1.2:1. The mean age was 62.1 (SD12.4) years. Patients were predominantly Chinese (67%), then Malays (18%), Indians (13%) and others (2%). Malays were younger than Chinese and Indians (mean age 57 versus 62 versus 62 years, p<0.001). More females (56%) had colon cancers compared to males (44%) (p=0.022). Malays (57%) had more rectal cancer compared to Chinese (45%) and Indians (49%) (p=0.004). Dukes' stage data weres available in 67%, with Dukes' C and D accounting for 64%. Stage was not affected by age, gender, ethnicity or tumor site. Treatment modalities included surgery alone (40%), surgery and chemo/radiotherapy 32%, chemo and radiotherapy (8%) and others (20%). Significant ethnic differences in age and site distribution, if verified in population-based settings, would support implementation of preventive measures targeting those with the greatest need, at the right age.

  8. Rice stem borers in Malaya. A proposal to use mutation breeding for their control

    Energy Technology Data Exchange (ETDEWEB)

    Vohra, F C [University of Malaya, Kuala Lumpur (Malaysia)

    1970-03-01

    The problem of rice stem borers: Among the various problems in the rice crop the loss caused by the larvae of lepidopterous stem borers seems to be very serious. In some districts of the Kurian area, the rate of damage has been as much as 100%. It is not unlikely that the stem borer threat will become worse with the introduction of double cropping in many areas. The control of stem borers has mainly been through the application of various insecticides, namely DDT, BHC, Endrin, dieldrin and gamma-BHC, and this has met with a certain amount of success. The chemical method of control, however, is not fully satisfactory because of: (a) The high recurrent cost in application; (b) The danger of hazard to man by residues; (c) The toxic effects to fish and mammals in the paddy fields; (d) The poisoning of the natural parasites of the borers; (e) The difficulties for proper application, exact concentrations etc. by untrained farmers; and (f) The probability for development of insecticide resistance in stem borers. Apparently there is an urgent need for some control free from chemical hazards. Scientists in various countries have turned to breeding for varietal resistance, among other approaches, to save the crop from damage by stem borers. The development of a variety of rice resistant to stem borers will provide an effective control operative at all levels of insect population without additional cost and inconvenience to the farmer. The research project: To achieve this objective a research project has recently been started as a co-operative venture at the School of Biological Sciences, University of Malaya, Kuala Lumpur. This project involves (a) Detailed ecological studies of boxers in different varieties of rice grown commonly in the various parts of the country; (b) A study of parasites of borers for possible biological control; and (c) Production of rice varieties resistant to stem borers through induction of mutations and hybridization with locally used types

  9. New Data on Conodonts of the Upper Devonian of the Polar Urals (Ostantsovy Section, Malaya Usa River

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    M.A. Soboleva

    2016-09-01

    Full Text Available The main features of the Upper Devonian sediments on the right side of the Ostantsovy Creek (the left tributary of the Malaya Usa River in the eastern part of the Bielsko-Eletskaya structural formational belt on the western slope of the Polar Urals have been considered. The late Frasnian age of these sediments has been determined on the basis of conodonts (the linguiformis zone of the standard conodont scale. The transition from clastic and organic limestones with massive stromatoporoid forms to limestones with fused (reservoir stromatoporoid forms and Palmatolepis biofacies is indicative of the transgressive shift of the linguiformis phase. This transgressive level is an indirect expression of the Upper Kellwasser global event.

  10. Integration of Structural Knowledge in Design Studio Project: Assessment Study of Curriculum In Architecture Course in University Of Malaya

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    Aniza Abdul Aziz

    2010-12-01

    Full Text Available Architectural education should advance in parallel with the industrial growth of building technology. Universities as producers of future architects have yet to develop curriculums for building technology to suit the growth of the building industry. This gap between education and industrial growth has been a topic of debate for many researchers who are concerned about architectural pedagogy. Architectural instruction further aggravated the problem whereby in most architectural schools worldwide, teaching is divided between the design studio, where the design projects are taught and lecture classes where the technical parts are taught. The latter should be integrated with design studio to enhance design levels. Students face difficulty integrating and applying the structural knowledge gained from structure classes into their design. One explanation for this deficiency is because the current architectural structure subject's content is borrowed from an engineering syllabus. This study will examine the course content, instruction styles and method of teaching structure subjects and will investigate the learning outcomes of design studio through students' performance and perception in integrating structural knowledge in their design projects. Respondents were students from Year 1 to Year 5 doing their Bachelor of Science in Architecture and Bachelor of Architecture degrees in University of Malaya. Semi-structured interviews were conducted with the design studio coordinators and structure lecturers. This study aims to find the ideal course content/method of teaching to facilitate more integration between structure and design studio.

  11. Ocular trauma injuries: a 1-year surveillance study in the University of Malaya Medical Centre, Malaysia. 2008.

    Science.gov (United States)

    Soong, Terrence Kwong-Weng; Koh, Alan; Subrayan, Visvaraja; Loo, Angela Voon Pei

    2011-12-01

    To describe the epidemiology of ocular injuries presenting to the University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia. Prospective analysis of all ocular trauma injuries presenting to the Department of Ophthalmology in UMMC from 1 January 2008 to 31 December 2008. A total of 603 eyes of 546 patients were recruited for the study. All patients presenting to the department with ocular trauma injuries were assessed by an ophthalmologist. Data on the type and source of injury, demographic profile of the patients, and clinical presentation were documented using a uniform and validated datasheet. Among eye injury cases, 481 patients (88.1%) were male, with a male-to-female ratio of 7.4:1. Of the patients, 412 (75.5%) were Malaysian while the remaining 134 (24.5%) were of non-Malaysian nationality. The average age was 31.5 years (range 1-81 years). A total of 238 injured eyes (43.6%) were work-related. The common sources of eye trauma include the use of high-powered tools (30.8%), motor vehicle accident (23.1%), and domestic accidents (17.7%). Only six patients (2.5%) reported to having used eye protective device (EPD) at time of their work-related injuries. A major cause of preventable ocular injuries in Malaysia was work-related trauma. Ocular injuries can be reduced by the use of eye protection devices and the implementation of appropriate preventive strategies to address each risk factor. Effective training is an integral part of occupational safety and health, which should be made mandatory at the workplace. In addition, there should be a continual assessment of safety and health issues at the workplace. A long-term database of all ocular injuries in Malaysia is recommended, to aid research on a larger scale and the development of new preventive strategies for ocular injuries.

  12. Molecular identification of adenovirus causing respiratory tract infection in pediatric patients at the University of Malaya Medical Center

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    AbuBakar Sazaly

    2010-07-01

    Full Text Available Abstract Background There are at least 51 adenovirus serotypes (AdV known to cause human infections. The prevalence of the different human AdV (HAdV serotypes varies among different regions. Presently, there are no reports of the prevalent HAdV types found in Malaysia. The present study was undertaken to identify the HAdV types associated primarily with respiratory tract infections (RTI of young children in Malaysia. Methods Archived HAdV isolates from pediatric patients with RTI seen at the University of Malaya Medical Center (UMMC, Kuala Lumpur, Malaysia from 1999 to 2005 were used. Virus isolates were inoculated into cell culture and DNA was extracted when cells showed significant cytopathic effects. AdV partial hexon gene was amplified and the sequences together with other known HAdV hexon gene sequences were used to build phylogenetic trees. Identification of HAdV types found among young children in Malaysia was inferred from the phylograms. Results At least 2,583 pediatric patients with RTI sought consultation and treatment at the UMMC from 1999 to 2005. Among these patients, 48 ( Conclusions HAdV-1 and HAdV-2 were the most common HAdV isolated from pediatric patients who sought treatment for RTI at the UMMC from 1999 to 2005. HAdV-B, mainly HAdV-3, was recovered from ~22% of the patients. These findings provide a benchmark for future studies on the prevalence and epidemiology of HAdV types in Malaysia and in the region.

  13. Molecular identification of adenovirus causing respiratory tract infection in pediatric patients at the University of Malaya Medical Center.

    Science.gov (United States)

    Abd-Jamil, Juraina; Teoh, Boon-Teong; Hassan, Eddy H; Roslan, Nuruliza; Abubakar, Sazaly

    2010-07-02

    There are at least 51 adenovirus serotypes (AdV) known to cause human infections. The prevalence of the different human AdV (HAdV) serotypes varies among different regions. Presently, there are no reports of the prevalent HAdV types found in Malaysia. The present study was undertaken to identify the HAdV types associated primarily with respiratory tract infections (RTI) of young children in Malaysia. Archived HAdV isolates from pediatric patients with RTI seen at the University of Malaya Medical Center (UMMC), Kuala Lumpur, Malaysia from 1999 to 2005 were used. Virus isolates were inoculated into cell culture and DNA was extracted when cells showed significant cytopathic effects. AdV partial hexon gene was amplified and the sequences together with other known HAdV hexon gene sequences were used to build phylogenetic trees. Identification of HAdV types found among young children in Malaysia was inferred from the phylograms. At least 2,583 pediatric patients with RTI sought consultation and treatment at the UMMC from 1999 to 2005. Among these patients, 48 (type 1 (HAdV-1) and HAdV type 2 (HAdV-2), and among the HAdV-B species, HAdV type 3 (HAdV-3) was the most common serotype identified. HAdV-C species also was isolated from throat and rectal swabs of children with hand, foot, and mouth disease (HFMD). Two isolates were identified as corresponding to HAdV-F species from a child with HFMD and a patient with intestinal obstruction. HAdV-1 and HAdV-2 were the most common HAdV isolated from pediatric patients who sought treatment for RTI at the UMMC from 1999 to 2005. HAdV-B, mainly HAdV-3, was recovered from approximately 22% of the patients. These findings provide a benchmark for future studies on the prevalence and epidemiology of HAdV types in Malaysia and in the region.

  14. Clinical Impact of Education Provision on Determining Advance Care Planning Decisions among End Stage Renal Disease Patients Receiving Regular Hemodialysis in University Malaya Medical Centre.

    Science.gov (United States)

    Hing Wong, Albert; Chin, Loh Ee; Ping, Tan Li; Peng, Ng Kok; Kun, Lim Soo

    2016-01-01

    Advance care planning (ACP) is a process of shared decision-making about future health-care plans between patients, health care providers, and family members, should patients becomes incapable of participating in medical treatment decisions. ACP discussions enhance patient's autonomy, focus on patient's values and treatment preferences, and promote patient-centered care. ACP is integrated as part of clinical practice in Singapore and the United States. To assess the clinical impact of education provision on determining ACP decisions among end-stage renal disease patients on regular hemodialysis at University Malaya Medical Centre (UMMC). To study the knowledge and attitude of patients toward ACP and end-of-life issues. Fifty-six patients were recruited from UMMC. About 43 questions pretest survey adapted from Lyon's ACP survey and Moss's cardiopulmonary resuscitation (CPR) attitude survey was given to patients to answer. An educational brochure is then introduced to these patients, and a posttest survey carried out after that. The results were analyzed using SPSS version 22.0. Opinion on ACP, including CPR decisions, showed an upward trend on the importance percentage after the educational brochure exposure, but this was statistically not significant. Seventy-five percent of participants had never heard of ACP before, and only 3.6% had actually prepared a written advanced directive. The ACP educational brochure clinically impacts patients' preferences and decisions toward end-of-life care; however, this is statistically not significant. Majority of patients have poor knowledge on ACP. This study lays the foundation for execution of future larger scale clinical trials, and ultimately, the incorporation of ACP into clinical practice in Malaysia.

  15. Islamic Reform in Malaya: The Contribution of Shaykh Tahir Jalaluddin

    OpenAIRE

    Hafiz Zakariya

    2005-01-01

    Abstract: Reformation of religion does not entail changing the very teaching of Islam or the introduction of un-Islamic elements into Islam. Rather reformation of religion is a return to the original sources of Islam as practiced during the period of the Prophet (SAS) and early generations of muslims, unadulterated by the practices and beliefs that contravened Islam. This salafī reformist discourse, as the historical evidence shows, was adopted by Shaykh Tahir in his attempts to reform Islam ...

  16. Research in the Botany Department. University of Malaya, Kuala Lumpur

    NARCIS (Netherlands)

    NN,

    1969-01-01

    Dr. B.C. Stone, the present Head of the Botany Unit, is continuing his investigations on Pandanaceae, which form the major research work; and on Rutaceae and Araliaceae, two other families which are his favorites. The genus Freycinetia is the nearest to completion; it is expected to have about

  17. 马来亚大学医学中心门诊糖尿病患者视网膜病变的发病率%Prevalence of retinopathy in diabetic patients referred from clinic in University of Malaya Medical Centre

    Institute of Scientific and Technical Information of China (English)

    I Tajunisah; SMS Sendhil Kumar; S C Reddy

    2008-01-01

    AIM: To evaluate the incidence of diabetic retinopathy and its risk factors among diabetic patients referred to eye clinic in University of Malaya Medical Centre. METHODS: This cross-sectional study included 200 eyes of 100 newly diagnosed diabetic patients. Relevant ocular and medical histories were recorded and full ocular examination of dilated fundus was performed in all the eyes. The retinopathy status was classified according to the Early Treatment Diabetic Retinopathy Study (ETDRS) criteria. The risk factors for retinopathy were evaluated by chi-square test and P value < 0.05 was taken as significant.RESULTS: The incidence of diabetic retinopathy among the newly diagnosed diabetic population in our study was 28%. Non-proliferative retinopathy was higher in type 2 diabetics (36%) compared to type 1 diabetics (24%). The incidence of retinopathy was not affected by the gender, age, race, socioeconomic status, type of diabetes and body mass index (BMI) in both types of diabetic patients. Patients with longer duration of disease with poorly controlled diabetes, hypertension, neuropathy, nephropathy, hyperlipidemia, and history of smoking had significantly higher incidence of retinopathy.CONCLUSION: Baseline screening for retinopathy in diabetic patients is desirable as early detection, regular follow-up, prompt referral to ophthalmologists and effective management will reduce and avoid severe vision loss for these patients.%目的:评估马来亚大学医学中心眼科门诊的糖尿病性视网膜病变的发病率和它在糖尿病患者中的危险因素.方法:该横向研究包括100例近期被诊断为糖尿病患者的200眼.采集有关的眼部和全身病史并对所有的眼进行彻底散瞳眼底检查.视网膜病变的状况根据早期糖尿病性视网膜病变治疗研究(ETDRS)的结果进行分类.造成视网膜病变的危险因素是通过卡方检验进行分析的,P< 0.05被认为有意义.结果:在我们的研究中,近期被诊断

  18. Methodology of Islamic psychotheraphy in Islamic boarding school Suryalaya Tasik Malaya

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    Khairunnas Rajab

    2014-12-01

    Full Text Available Islamic Psychotherapy is a methodology that is based on the Quran andSunnah. The Quran and Sunnah are sources of knowledge. Islamic psychotherapyprovides solutions to mental disorder. Suryalaya Boarding school hasprovided guidance to patients who are addicted to drugs in order to be recovered.The Islamic psychotherapy model applied at the boarding school is theSufism-based approach. Sufism is a way to get closer to God. Through theapproach, drug-addicted patients can be cured. If the patients realize that Godanswers their prayers through worship, the sense of sinfulness and guiltinesswill gradually disappear. The boarding school has been implementing Islamicpsychotherapy of Qadiriyyah-Naqsyabandiyyah approach. Through the approach,the patients succeeded to be completely recovered. This article attempts toexplain the important roles of the school in treating patients suffering frommental disorder due to misuse of drugs.Psikoterapi Islam adalah sebuah metodologi yang berdasarkan al-Qur’an danal-Sunnah. Al-Qur’an dan al-Sunnah adalah sumber ilmu pengetahuan.Psikoterapi Islam memberikan solusi bagi orang-orang yang mengalamigangguan mental. Pondok Pesantren Suryalaya telah melakukan pembinaan terhadap pasien yang kecanduan narkotika. Model psikoterapi Islam yangditerapkan di pondok pesantren ini adalah psikoterapi dengan pendekatantasawuf. Melalui pendekatan Tasawuf pasien narkotika dapat dipulihkan.Tasawuf adalah upaya seseorang untuk mendekatkan diri kepada Tuhannya.Apabila pasien narkotika menyadari bahwa Allah mengabulkan doa-doa melaluiibadah, maka perasaan berdosa dan bersalah secara bertahap akan hilang.Pondok Pesantren Suryalaya selama ini telah menerapkan sebuah modelpsikoterapi Islam dengan pendekatan thariqat Qadiriyyah-Naqsyabandiyyah.Dengan Thariqat Qadiriyyah-Naqsyabandiyah pasien-pasien narkotika dapatdisembuhkan secara sempurna. Artikel ini berupaya menjelaskan peran pentingPondok Pesantren Suryalaya dalam penyembuhan pasien yang mengalamigangguan mental akibat penyalahgunaan narkotika.

  19. Energy Performance of Three Residential College Buildings in University of Malaya Campus, Kuala Lumpur

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    Adi Ainurzaman Jamaludin

    2011-12-01

    Full Text Available Three residential colleges located in Kuala Lumpur, Malaysia, were selected for energy performance analysis in regards to its implementation of bioclimatic design strategies. Specifically, passive design strategies on daylighting and natural ventilation were examined. In Malaysia, the residential college or hostel is a multi-residential building providing accommodation to university students. The three residential colleges in this study, namely C1, C2 and C3, were built in different years with different designs and forms, particularly with regards to enclosure and facade design, solar control devices, passive daylight concepts, and natural ventilation strategies. The building designs were carefully studied and an electric consumption analysis was carried out in each residential college. This study revealed that the wide-scale implementation of bioclimatic design strategies in college C2 help reduced the annual energy consumption. The building bioclimatic design features that are accountable to reduce energy consumption are the internal courtyard and balconies on each unit of floor area, as shown in C3.Results from this study highly recommend internal courtyard and balcony building combination for multi residential building design, especially in tropical urban regions.

  20. Dynamics of glacial lakes in Malaya Almatinka River basin according to the ground-based monitoring data

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    N. N. Kasatkin

    2014-01-01

    Full Text Available Monitoring of three moraine lakes (two of which are located on frontal moraines, and one is lateral lasted some years. It was defined that each lake has individual temperature mode which depends partly by air temperature and much more by incoming melted waters, volumeof their accumulation and typeof underlying rocks. Type of underlying rock in which the lake kettleis formed has decisive importance. Direct contact of lake water with glacierice gives its temperature during ablation period of 2.54 °С or in 3.1 times lower, than in frontal lakes. That’s why the dam quicklycollapses and the lake volume increases. Dams of the lakeslocated on frontal moraines are subject of destructionmuch less. Dynamics of these lakes is caused by retreat of glaciers, and the maximum depths are fixed in the central part of a lake. Water temperatureduring the cold period remainshere steadily positive and promotesformation of filtration channels in the layer with moraine sediments which almost without ice. The increasing of lakes occurs due to ice ablation from the nearest glacier. Precipitations, if they influence to the change of water level in lakes, are not essential.

  1. The genus Odontofroggatia Ishii (Hymenoptera Chalcidoidea, Pteromalidae Epichrysomallinae)

    NARCIS (Netherlands)

    Wiebes, J.T.

    1980-01-01

    Descriptions of three new species of Odontofroggatia: corneri (type locality Penang, Malaya; also recorded from Perak, Malaya and from the Solomon Island Ysabel), galili (type locality Ein Geddi, Israel; also recorded from Perak, Malaya) and ishii (type locality Penang, Malaya) are given. For all

  2. The development and validation of the Satisfaction Questionnaire for Osteoporosis Prevention in Malaysia

    OpenAIRE

    Lai, Pauline Siew Mei; Toh,Li Shean; Wong,Kok Thong; Tan,Alex Tong Boon; Low,Bee Yean; Anderson,Claire; Wu,David Bin-Chia

    2014-01-01

    Li Shean Toh,1 Pauline Siew Mei Lai,2 David Bin-Chia Wu,3 Kok Thong Wong,1 Bee Yean Low,1 Alexander Tong Boon Tan,4 Claire Anderson5 1School of Pharmacy, University of Nottingham, Semenyih, Malaysia; 2Department of Primary Care Medicine, University of Malaya Primary Care Research Group, University of Malaya, Kuala Lumpur, Malaysia; 3School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia; 4Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 5Division of Soci...

  3. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2. Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol 678, Iran; Nanotechnology & Catalysis Research Centre (NANOCAT), IPS Building, University Malaya, 50603 Kuala Lumpur, Malaysia ...

  4. Miscellaneous information

    NARCIS (Netherlands)

    NN,

    1974-01-01

    The limestone flora of Malaya. Under this title, Mr. S. C. Chin submitted a M.Sc. thesis in typescript in March 1973 at the University of Malaya, Kuala Lumpur. Supervisor was Dr. B.C. Stone. Hitherto, Henderson’s work of 1939 was the only study on the subject, with 745 spp. in all, about 195 of them

  5. Addition to chapter VI b (p. 2011)

    NARCIS (Netherlands)

    NN,

    1972-01-01

    Botanic Garden at the University of Malaya. A plan was submitted by Professor W.R. Stanton, head of the Botany Division, University of Malaya, K.L., to establish a new botanic garden of some 100 acres as a teaching facility and for the benefit of biological education institutes and the general

  6. Malayan Chinese Who Were Deported to China

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    Hara Fujio

    2017-12-01

    Full Text Available Relying on two volumes of Who’s Who published by ex-Malayan Chinese who were forced to come to China between 1948 and 1963, this author intends to investigate (1 where these deportees were born / originated and in which province they settled, (2 their occupations in Malaya and in China, (3 their political affiliations / activities both in Malaya and in China, (4 their educational background both in Malaya and China, (5 their condition in China, and (6 correlations among some of these factors.

  7. Geochemical study of volcanic and associated granitic rocks from ...

    Indian Academy of Sciences (India)

    1Department of Geology, University of Malaya, 50603 Kuala Lumpur, Malaysia. 2Institute of Biological ... of the Johor National Park, Endau Rompin are different and probably have different sources. The geo- ...... University Press). Masuda A ...

  8. BARF1 gene silencing triggers caspase-dependent mitochondrial ...

    Indian Academy of Sciences (India)

    2015-02-04

    Feb 4, 2015 ... apoptosis in Epstein-Barr virus-positive malignant cells. TAZNIM BEGAM MOHD ... University of Malaya, Kuala Lumpur, Malaysia. *Corresponding ... 40(1), March 2015, 41–51, * Indian Academy of Sciences. 41. Keywords.

  9. A simple, rapid and efficient method of isolating DNA from ...

    African Journals Online (AJOL)

    ONOS

    2010-09-06

    Sep 6, 2010 ... achieving food security and sustainable agriculture. (Hautea and Escaler, 2004). ... presence of these contaminants tends to suppress and inhibit analytical ... garden in University of Malaya, Malaysia. Leaves were harvested.

  10. Phytochemical Constituents and Analgesic Activity of Ethyl Acetate ...

    African Journals Online (AJOL)

    Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia ... Punicalagins inhibit proliferation of human tumor ... out in strict compliance with the ethical guidelines ..... resources in Turkmenistan.

  11. Relapse to opioid use in opioid-dependent individuals released from compulsory drug detention centres compared with those from voluntary methadone treatment centres in Malaysia: a two-arm, prospective observational study

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    Martin P Wegman, BSc

    2017-02-01

    Funding: The World Bank Group, Doris Duke Charitable Foundation, National Institute on Drug Abuse, Australian National Health & Medical Research Council, National Institute of Mental Health, and the University of Malaya-Malaysian Ministry of Higher Education High Impact Research Grant.

  12. Effect of benzylaminopurine (BAP) pulsing on in vitro shoot ...

    African Journals Online (AJOL)

    user

    2011-03-28

    Mar 28, 2011 ... Research Cluster, Faculty of Science, University Malaya, 50603 Kuala Lumpur, Malaysia. Accepted 12 ... number of bud formation in shoot cultures of Musa acuminata cv. ... In tissue culture, plant growth regulators (PGR) are.

  13. Plasma proteome analysis of cervical intraepithelial neoplasia

    Indian Academy of Sciences (India)

    ... Malaysia and University of Malaya Centre For Proteomics Research (UMCPR), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; Department of Clinical Oral Biology, Faculty of Dentistry; Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; Department of Obstetrics and Gynecology; Universiti Kebangsaan ...

  14. Chemical composition of essential oil of exudates of Dryobalanops ...

    African Journals Online (AJOL)

    Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia, ... Gas chromatography-mass spectrometry (GC-MS) was used to characterize the ... Conclusion: Essential oil from the exudates of D. aromatica contains ..... industries.

  15. Effect of Interaction between Polymorphisms in Insulin Receptor ...

    African Journals Online (AJOL)

    Centre, 13th Floor, Main Tower University of Malaya Medical Centre, 59100 Lembah Pantai, Kuala Lumpur, ... Lumpur, Malaysia, 6Department of Biochemistry, Faculty of Medicine, Universiti ..... Malaysia for financial and technical support.

  16. An analysis of Malaysia road traffic death distribution by road ...

    Indian Academy of Sciences (India)

    Yusria Darma

    2017-07-14

    Jul 14, 2017 ... 1 Center for Transportation Research, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur,. Malaysia .... Materials and methods. 2.1 Data ... accident, the number and type of vehicles involved in the accident ...

  17. Gain-clamping techniques in two-stage double-pass L-band EDFA

    Indian Academy of Sciences (India)

    Author Affiliations. S W harun1 N Md Samsuri2 H Ahmad2. Faculty of Engineering, Multimedia University, Jalan Multimedia, 63100 Cyberjaya, Selangor, Malaysia; Photonics Laboratory, Department of Physics, University of Malaya, 50603 Kuala Lumpur, Malaysia ...

  18. Affective, Cognitive, and Behavioral Consistency of Chinese-Malay Interracial Attitudes

    Science.gov (United States)

    Rabushka, Alvin

    1970-01-01

    This study, part of an overall study of political and social integration in Malaya carried out in 1966-67, has resulted in findings that vary from consistency theory research in developed countries. (DB)

  19. Pigment identification and antioxidant properties of red dragon fruit ...

    African Journals Online (AJOL)

    STORAGESEVER

    2010-03-08

    Mar 8, 2010 ... Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala .... Bae and Suh (2007) reported that active oxygen species .... selected additives. ... betalains in plants, food and in human nutrition.

  20. Research Article Special Issue

    African Journals Online (AJOL)

    2017-10-05

    Oct 5, 2017 ... Author Correspondence, e-mail: syleow88 ... explore the pruning effects on a hybrid mode sequential learning algo ... eering, University of Malaya,. 17 e .... the same neuron J to be chosen again, a very small positive constant.

  1. Britská politika vůči Malajsku a jeho dekolonizace v letech 1945 až 1971

    OpenAIRE

    Hladíková, Kristýna

    2011-01-01

    The bachelor thesis deals with the British policy towards Malaya and its decolonisation between 1945 and 1971. It aims to learn and describe how British cabinet approached to Malaya in the chosen time period, and to define goals of the monarchy for this country. The goals were being often changed or modified. The thesis follows also the circumstances (Malayan national demands, bad domestic economic situation, decreasing position in international politics, growing imperial commitments, the Col...

  2. The Importance of Culture in Emic Interpretations of the History of Thailand’s Southern Separatist Movement: The “Gentlemen’s Agreement” of 1943 and the Malaysian Relationship with the Separatists

    OpenAIRE

    Otto F. von Feigenblatt

    2010-01-01

    This paper explores the role of culture in two important eventsin the history of the separatist struggle in the Muslim South of Thailand. The first event was the “gentlemen’s agreement” of 1943, promising Britain’s support for independence or annexation to British Malaya in exchange of military and intelligence support against the Japanese, between the traditional Melayu leadership and the British Colonial Office represented by the commander of the British forces in Malaya during World War II...

  3. A Brief Survey of the Mosquitoes of South Sulawesi, Indonesia, with Special Reference to the Identity of ’Anopheles barbirostris’ (Diptera: Culicidae) from the Margolembo Area

    Science.gov (United States)

    1977-06-20

    mosquitoes hitherto recorded from Sulawesi and adjacent islands is presented. The prevalence of malaria and filariasis in transmigration villages of...East Indian mosquitoes. Bull. Ent. Res. 25: 501-19, illus. 1939. Notes on Dutch East- Indian mosquitoes. Tij&hr. Ent. 82: 91-113, illus. Brug, S...Macdonald, W. W. 1957. Malaysian parasites. XVI. An interim review of the non-anopheline mosquitoes of Malaya. Stud. Inst. Med. Res., Malaya 28: l-34

  4. Saudara (1928-1941: Continuity and Change in the Malay Society

    Directory of Open Access Journals (Sweden)

    Wan Suhana Wan Sulong

    2006-12-01

    Full Text Available Abstract: A content analysis of Saudara, published in the Straits Settlement of Penang between 1928 and 1941, shows the development of Malay social, political and religious thinking in a crucial period of transition in Malay society. The analysis of various issues debated in this newspaper contributed to the social history of Malaya and of the Malay community within Malaya. The issues raised in Saudara are echoed in contemporary Malaysia with varying emphasis and elements.

  5. Malaysian perceptions of China

    OpenAIRE

    Ibrahim Abu Bakar

    2009-01-01

    Malasia que consistía en Malaya, Sabah, Sarawak y Singapur ganó su independencia de los Británicos el 16 de septiembre de 1963. Malaya ganó su independencia de los británicos el 31 de agosto de 1957. En 1965 Singapur era independiente de Malasia. Malasia es una democracia parlamentaria y capitalista. Por otra parte, es una nación multi-religiosa y multirracial. Malasia ha sido poblada por los Malays, los Chinos, los Indios y otros. Los Malays son musulmanes y el Islam es la religión de la fed...

  6. Politics, Security and Early Ideas of ‘Greater Malaysia’, 1945-1961

    OpenAIRE

    Fernando, Joseph M.; Rajagopal, Shanthiah

    2017-01-01

    The formation of the Federation of Malaysia in 1963 remains a source of much debate among historians. The official announcement by the Prime Minister of Malaya, Tunku Abdul Rahman, on 27 May 1961, urging a closer association of Malaya, Singapore and the three British-controlled Borneo territories is viewed by some studies as the trigger that led to the formation of Malaysia on 16 September 1963. While this study recognizes that Tunku’s proposal of May 1961 was a catalyst to the formal negotia...

  7. Forming the Academic Profession in East Asia: A Comparative Analysis. East Asia: History, Politics, Sociology, Culture. A Routledge Series.

    Science.gov (United States)

    Kim, Terri

    This book is a comparative examination of the formation of the academic profession in Korea and Malaya, and later, South Korea, Malaysia, and Singapore, from colonial times. The analysis takes into account the connections and disconnections between the colonial and postcolonial periods in shaping the academic profession. The chapters are: (1)…

  8. Enhancing Employability through Industrial Training in the Malaysian Context

    Science.gov (United States)

    Pillai, Stefanie; Khan, Mahmud H.; Ibrahim, Ida Syahirah; Raphael, Sharmane

    2012-01-01

    This study discusses the industrial training programme at the University of Malaya in Malaysia, specifically the issues that need to be addressed in order to enhance the employability skills of graduates. Findings from the feedback obtained from trainees and organizations in the 2008/2009 academic session were examined in terms of the extent to…

  9. Obstetric and perinatal outcome in teenage pregnancies

    African Journals Online (AJOL)

    2013-09-02

    Sep 2, 2013 ... subjects gave birth in the Department of Obstetrics and Gynaecology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia, a referral ... Factors that may contribute to this problem are lack of education and information .... be relevant to the origins of some child mental health disorders. Our study ...

  10. Factors affecting estrogen receptor status in a multiracial Asian country : An analysis of 3557 cases

    NARCIS (Netherlands)

    Yip, C. H.; Pathy, N. Bhoo; Uiterwaal, C. S.; Taib, N. A.; Tan, G. H.; Mun, K. S.; Choo, W. Y.; Rhodes, A.

    Estrogen receptor (ER) positive rates in breast cancer may be influenced by grade, stage, age and race. This study reviews the ER positive rates over a 15-year period at the University Malaya Medical Centre, Kuala Lumpur, Malaysia. Data on ER status of 3557 patients from 1994 to 2008 was analyzed.

  11. Benzenesulfanohydrazide Schiff Base and its Anti- Ulcer Activity in ...

    African Journals Online (AJOL)

    HP

    Malaya, 50603 Kuala Lumpur, Malaysia. Abstract ... of benzene- sulfanohydrazones and their complexes [2]. Previous work on synthesis and ... activities [4]. This study extends this work by ... balance in a 100 ml beaker and dissolved in ..... induced by ethanol in gastric mucosa of rats. J. Life Sci. 2000; 67: 559-566. 9.

  12. Calculation of hyperfine structure constants of small molecules using ...

    Indian Academy of Sciences (India)

    SUDIP SASMALa, KAUSHIK TALUKDARb, MALAYA K NAYAKc, NAYANA VAVALa and. SOURAV PALb,∗ ... Abstract. The Z-vector method in the relativistic coupled-cluster framework is employed to calculate the parallel and perpendicular .... subscript c means only the connected terms exist in the contraction between HN ...

  13. Stimulating Student Interest in Physiology: The Intermedical School Physiology Quiz

    Science.gov (United States)

    Cheng, Hwee-Ming

    2010-01-01

    The Intermedical School Physiology Quiz (IMSPQ) was initiated in 2003 during the author's last sabbatical from the University of Malaya. At this inaugural event, there were just seven competing teams from Malaysian medical schools. The challenge trophy for the IMSPQ is named in honor of Prof. A. Raman, who was the first Malaysian Professor of…

  14. Misconceptions Highlighted among Medical Students in the Annual International Intermedical School Physiology Quiz

    Science.gov (United States)

    Cheng, Hwee-Ming; Durairajanayagam, Damayanthi

    2012-01-01

    The annual Intermedical School Physiology Quiz (IMSPQ), initiated in 2003, is now an event that attracts a unique, large gathering of selected medical students from medical schools across the globe. The 8th IMSPQ, in 2010, hosted by the Department of Physiology, University of Malaya, in Kuala Lumpur, Malaysia, had 200 students representing 41…

  15. Conspectus of the genus Amyema Tieghem (Loranthaceae)

    NARCIS (Netherlands)

    Barlow, Bryan A.

    1992-01-01

    The Australasian/Malesian genus Amyema is reviewed. Particular attention is given to the species of the Malesian region, as a precursor to a treatment of Loranthaceae for Flora Malesiana. Amyema comprises 92 species, and is distributed from the southeast Asian mainland (Malaya, Thailand) throughout

  16. Fatal Gastrointestinal Perforations in sudden death cases in Last 10 ...

    African Journals Online (AJOL)

    Pathology unit of University Malaya, Kuala Lumpur in the year 2006 by reviewing the autopsy reports. There were 61 cases of GIT perforation out of 5579 autopsies conducted during a period of ten years (1996-2005). The incidence rate of fatal gastrointestinal perforation was 1.09% during this period. Out of these 61 cases, ...

  17. Personal news

    NARCIS (Netherlands)

    NN,

    1966-01-01

    Dr. P. S. Ashton has taken up an appointment as a lecturer in botany at the University of Aberdeen, Scotland, after the completion of his work in Sarawak in September 1966. A programme of cooperation has come into existence between the universities of Aberdeen and Kuala Lumpur, Malaya. Dr. Ashton’s

  18. Keep the forests keep the forests keep the forests! The Kepong Round Table Conference on Dipterocarps

    NARCIS (Netherlands)

    Jacobs, M.

    1981-01-01

    ”Look, these are the modern trees”, Kostermans remarked, pointing to some concrete piles lying near the Forest Research Institute. None of the participants could have missed the sad impression of a moonscape around Kuala Lumpur, which tells of the construction boom in Malaya. ”In Thailand, timber

  19. CULTURAL FRONTIERS OF THE PEACE CORPS.

    Science.gov (United States)

    TEXTOR, ROBERT B., ED.

    THE PRESENT WORK CONTAINS ANALYSES OF PEACE CORPS PROGRAMS IN SELECTED HOST COUNTRIES (THE PHILIPPINES, MALAYA, THAILAND, PERU, BOLIVIA, AFGHANISTAN, SOMALIA, NIGERIA, TANGANYIKA, SIERRA LEONE, TUNISIA, MOROCCO, AND JAMAICA) WRITTEN BY AN AUTHORITY ON EACH COUNTRY. COVERAGE OF DOMESTIC OPERATIONS OF THE PEACE CORPS IS STRICTLY LIMITED TO WHAT IS…

  20. The study of minor forest products

    NARCIS (Netherlands)

    Jacobs, M.

    1982-01-01

    Rattans as an example. — ’Minor’ are called all forest products other than timber. Rattan is one of the best-known. In Malaya, according to Dransfield in his book of 1979, there are 104 species; 54 of them are utilized for cane. In addition, 4 are sought for their edible fruits, 5 for their leaves

  1. All rights reserved Development of Headspace Solid-Phase ...

    African Journals Online (AJOL)

    ADOWIE PERE

    1 Department of Chemistry, Faculty of Science, University of Malaya, Pantai ... mixture of organic solvents was optimized using design of experiment (DOE) with simplex ... food pose a potential health risk to animal and human ... The GC oven temperature program was .... sample pH also helps to transform the analytes into.

  2. Recruitment and Financing of Candidates To Study Overseas: Its Implications for Australia.

    Science.gov (United States)

    Smart, Don

    Growing numbers of Malaysian students are going to Australia for overseas study. This paper begins with a discussion of Malaysia's New Economic Policy, whose provisions include a phasing out of English as the language of instruction in favor of Bahasa Malaya, the language of the indigenous Malay majority. This policy provides a background for the…

  3. Boekbesprekings / Book Reviews

    African Journals Online (AJOL)

    basic theories of communist insurgency and of counter insurgency as they operate on the ground and affect the population of a threatened country. Much of what is propagated in this book have been experienced by the SADF during its strug- gle against insurgency. Some of the systems used in Malaya and Vietnam was ...

  4. Evaluation of Palm Oil-Based Paracetamol Suppositories by ...

    African Journals Online (AJOL)

    Tropical Journal of Pharmaceutical Research January 2014; 13 (1): 23-29. ISSN: 1596-5996 (print); ... Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur-50603, Malaysia .... donated by Hesego Industry (M) Sdn Bhd,. Esterchem (M) ... stainless steel suppository moulds and the paracetamol ...

  5. Malaysian Students' Perceptions of Flipped Classroom: A Case Study

    Science.gov (United States)

    Zainuddin, Zamzami; Attaran, Mohammad

    2016-01-01

    The purpose of this study was to evaluate a class in University of Malaya where flipped learning was applied, and to examine students' perceptions and feedback towards flipped classroom. Data were collected using both quantitative and qualitative methods, i.e. survey, focus group and individual interviews. The results indicated that most students…

  6. A canopy observation platform in East Kalimantan, Indonesia

    NARCIS (Netherlands)

    Leighton, Mark; Thomas, Barry

    1980-01-01

    Tropical biologists are often frustrated in their attempts to study plants, animals, and climate in the forest canopy because of the difficulty of access to this region 20-50 meters high. This problem can be overcome by the use of free-standing towers (Pasoh, Malaya; Barro Colorado Island, Panama)

  7. Florae Malesianae Praecursores LX. The Oleaceae of Malesia. II. The genus Olea

    NARCIS (Netherlands)

    Kiew, Ruth

    1979-01-01

    Olea comprises six species in Malesia: two from Malaya. O. brachiata (Lour.) Merrill (formerly O. maritima Wall. ex G. Don) and O. dentata Wall. ex G. Don (formerly O. penangiana Ridley); two from Borneo, O. borneensis Boerl. and O. decussata (Heine) Kiew and two from Java, O. javanica (Bl.) Knobl.

  8. How Insurgencies End

    Science.gov (United States)

    2010-01-01

    analysis of the full range of 89 cases leads us to a middle ground in terms of conventional wisdom: Security and democratization (or at least electoral ...Malaya, 1948–1960 x Colombia (La Violencia ), 1948– 1962 x Kenya, 1952–1956 x Cuba, 1953–1959 x Algerian independence, 1954– 1962 x Lebanon, 1958–1959

  9. comparative study on the proximate content of the flesh of red and ...

    African Journals Online (AJOL)

    Bashar

    bleomycin-induced genotoxicity in Chinese hamster ovary cells. Cancer Letters. 152;. 115-122. Christian, A. and Ukhun, E. (2006): Nutritional potential of the nut of tropical almond. (Terminalia catappa. L.). Pakistan Journal of. Nutrition. 5(4); 334-336. Corner, E.J.H. (1997): Way side trees of Malaya. 4th edition: The Malayan ...

  10. Breast cancer in a multi-ethnic Asian setting : Results from the Singapore-Malaysia hospital-based breast cancer registry

    NARCIS (Netherlands)

    Pathy, Nirmala Bhoo; Yip, Cheng Har; Taib, Nur Aishah; Hartman, Mikael; Saxena, Nakul; Lau, Philip; Bulgiba, Awang M.; Lee, Soo Chin; Lim, Siew Eng; Wong, John E. L.; Verkooijen, Helena M.

    Two hospital-based breast cancer databases (University Malaya Medical Center, Malaysia [n = 1513] and National University Hospital, Singapore [n = 2545]) were merged into a regional registry of breast cancer patients diagnosed between 1990 and 2007. A review of the data found 51% of patients

  11. Review

    NARCIS (Netherlands)

    Steenis, van C.G.G.J.

    1970-01-01

    This is primarily a textbook for students, providing a synopsis of orders and families of Gymnosperms, Dicotyledons, and Monocotyledons native, naturalized, and commonly cultivated in Malaya and Singapore. It emerged from a syllabus prepared by the author in 1960. There is a brief introduction. The

  12. Resensi Buku Islamic Perspective on Management: Contemporary Issues

    OpenAIRE

    Kusuma, Bayu Mitra Adhyatma

    2016-01-01

    Judul buku : Islamic Perspective on Management: ContemporaryIssuesPenulis : Nor ‘Azizah Kamri, dkk.Penerbit : YaPEIM Management Academy (kerjasamadengan University of Malaya Press)Tebal : xiv + 463 halamanCetakan pertama : November 2013Kota terbit : Kuala Lumpur

  13. Personal news

    NARCIS (Netherlands)

    NN,

    1982-01-01

    Ms. Wanda Ave, a student of biology at Leiden with interest in ethnobotany, prepared 30 maps with text for Pacific Plant Areas, then studied rattan species of Malaya, where she went in March 1982 to work on smallscale utilization of rattan by indigenous tribes. Dr. M.M.J. van Balgooy, duly elected

  14. Re-appraisal of the P, T-odd interaction constant Wd in YbF ...

    Indian Academy of Sciences (India)

    ... Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Pramana – Journal of Physics; Volume 73; Issue 3. Re-appraisal of the , -odd interaction constant d in YbF: Relativistic configuration interaction approach. Malaya K Nayak Rajat K Chaudhuri. Volume 73 Issue 3 September 2009 ...

  15. The effect of radioactive waste storage in Andreev Bay on contamination of the Barents Sea ecosystem

    Science.gov (United States)

    Matishov, G. G.; Ilyin, G. V.; Usyagina, I. S.; Moiseev, D. V.; Dahle, Salve; Kasatkina, N. E.; Valuyskaya, D. A.

    2017-02-01

    The effect of temporary radioactive waste storage on the ecological status of the sea and biota in the littoral of Andreev and Malaya Andreev bays and near the shore of Motovskii Gulf (including the mouth part of the Zapadnaya Litsa Bay) was analyzed. The littoral sediments contaminated by the 137Cs, 90Sr, 238Pu, and 239,240Pu isotopes are located in the zones of constant groundwater discharge on the shores of Andreev and Malaya Andreev bays. The littoral slopes and bottom depressions of the bays accumulate finely dispersed terrigenous material and 137Cs. The investigations have shown that the storage does not exert a significant adverse effect on the radioactive conditions and the status of the sea ecosystems beyond Andreev Bay.

  16. Rehearsing citizenship

    DEFF Research Database (Denmark)

    Triantafillou, Peter; Moreira, Afonso

    2002-01-01

    This article traces the sudden problematisation and governing of juvenile delinquency in British colonial Malaya in the decade preceding independence in 1957 whereby a juvenile court system, a network of institutions for delinquents, and a series of training and disciplinary practices were set up...... to rehabilitate the delinquent in order to turn him into a responsible citizen. Drawing on the analytics of disciplinary and ethical practices conducted by Michel Foucault, it is argued that the governing of juvenile delinquency in colonial Malaya may be seen as a fundamental element of a wider assemblage...... of normalising techniques seeking to recast subjectivity from that of immature individuals into active and responsible self-governing ones, and that these techniques were highly dividing in that they produced not only what is taken to be good citizens but also delinquents. It is shown that Malaysian independence...

  17. Bullets, Bombs, and Bystanders: The Strategic Implications of Collateral Damage in Afghanistan

    Science.gov (United States)

    2010-05-15

    Malaysia , Palestine, Turkey, and several others. The significant increase in these wars of liberation was a result of the declining influence of colonial...parts of Malaya and then hunt them down remorselessly.29 Ultimately, the endeavor ended in success for the British and the government of Malaysia ...international news franchises which provide immediate feedback on every aspect of the conflict. Military leaders are unable to shape the news

  18. Countering the al-Shabaab Insurgency in Somalia: Lessons for U.S. Special Operations Forces

    Science.gov (United States)

    2014-02-01

    correctly, that such an esteemed lineage is apocryphal, it is still an important founding myth for the Somali people and an indicator of their wish to...urban elites. Flush with money and with access to the halls of power, they used land registration laws (backed with a healthy dollop of armed...node/108486. 345. Nagl, John A. Learning to Eat Soup with a Knife: Counterinsurgency Lessons from Malaya and Vietnam. Paperback ed. Chicago: University

  19. An Exit Strategy Not a Winning Strategy? Intelligence Lessons from the British ’Emergency’ in South Arabia, 1963-67

    Science.gov (United States)

    2012-12-14

    beyond the relatively successful campaigns in Malaya, Oman and Northern Ireland and seek out the less fashionable , unsuccessful campaigns. The campaign...Al Qaeda franchise in the world - Al Qaeda in the Arabian Peninsula (AQAP). AQAP was responsible for three major international terrorist...explained in, arguably, even more derogatory fashion as straightforward “banditry.” The latter lacks the harsh moral condemnation of “terrorism

  20. The Past is a Foreign Country -- Understanding the British Approach to Counterinsurgency

    Science.gov (United States)

    2013-05-23

    counterpoint to the near contemporary Malayan campaign. The Aden Emergency and South Arabian campaign (examined as a single case study) is chosen because it...which the British had intended to use to bring equal rights to the Chinese and Indian populations of Malaya.29 The Plan was fiercely opposed by the...1942-1948 (Kuala Lumpar: Malaysian Branch of the Royal Asiatic Society (Monograph No.8), 1979). 30 The author experienced this tendency to

  1. Determinants of Malaysian and Singaporean Economics Undergraduates' Academic Performance

    OpenAIRE

    Chang Da Wan; Roland K. Cheo

    2012-01-01

    This study examines the determinants of economics undergraduates' academic performance in the top national universities of Singapore and Malaysia: the National University of Singapore (NUS) and the University of Malaya (UM). Using three basic components of economics as the dependent variable, i.e. basic microeconomics, basic macroeconomics and statistics/econometrics, it was found that students' pre-university grade is the most important determinant in undergraduates' performance. However, un...

  2. Challenges to Malaysia’s National Security

    Science.gov (United States)

    1990-04-09

    royal regatta escorted by loyal Chinese warriors and accompanied by charming maids.4 This event was the beginning of the present " Baba and Nyonya ...Century there were two distinct groups of Chinese in Malaya. One consisted of the Baba - Nyonya or Straits Chinese, born and lived for the most part in...the Straits Settlements of Melaka and Penang Island, where their ancestors had come to enjoy the British law and order. The Babas (males) and the

  3. The Biggest Stick: The Employment of Artillery Units in Counterinsurgency

    Science.gov (United States)

    2011-06-10

    83 59Riley Sunderland, Organizing Counterinsurgency in Malaya, 1947-1960 (Santa Monica, CA: RAND, 1964), 17. 60The Virgin Soldiers, ―British...on the night of 30-31 January 1968 in the midst of the largest holiday on the Vietnamese calendar, and it culminated within two weeks except in Hue...executed bodies per month to a pacified environment in which locals brought American soldiers food on holidays .191 The glaring negative effect was

  4. A Garden City in Southeast Asia

    OpenAIRE

    O'Neill, Jesse

    2017-01-01

    Not long after Ebenezer Howard’s Tomorrow: A Peaceful Path to Real Reform, the English ‘garden city’ became an aspirational urban model for places in colonial Malaya like Kuala Lumpur, Kuching and Singapore. What originally responded to nineteenth century industrial expansion was in this context a reaction to early twentieth century laissez-faire urbanism, aiming to beautify cities, improve health, and boost commerce. From the 1950s, private developers announced their ‘garden cities’, which c...

  5. The Worst Disaster: The Decisive Point and the Fall of Singapore

    Science.gov (United States)

    2007-11-06

    British territory of Malaya includes Singapore. In 1957, Malaysia became an independent state. In 1965, ore seceded from Malaysia . A.J Kennedy, A...repulsed? Per the leisurely pace of Singapore’s defense planning to date, it would certainly have been uncharacteristic of the entire Singapore... leisurely pace, Britain’s pre-WWII operational commanders were unable to compensate for a newly identified decisive point. Conversely, today’s

  6. The Himalayas revisited

    Digital Repository Service at National Institute of Oceanography (India)

    Iyer, S.D.; Mukhopadhyay, R.

    - crystallization and grain boun d ary migration occurring simultaneously in different minerals from several regions in the Hi malayas; the process appears to be repeated in cyclic order during progre s- sive deformation. R. Islam and others found ophiolitic... may have fine - tuned the geomagnetic inversion of the metamorphic sequence, advo cating the theory of post - metamor - phic tectonic modification. Considering the large - scale tecto nic activities and associated metamorphism...

  7. Rehearsing citizenship

    DEFF Research Database (Denmark)

    Triantafillou, Peter; Moreira, Afonso

    2002-01-01

    This article traces the sudden problematisation and governing of juvenile delinquency in British colonial Malaya in the decade preceding independence in 1957 whereby a juvenile court system, a network of institutions for delinquents, and a series of training and disciplinary practices were set up......, far from leading to a break with these power-laden practices of citizenship, instead leads to their further development, dispersal and institutionalisation....

  8. Overview of Breast Cancer in Malaysian Women: A Problem with Late Diagnosis

    OpenAIRE

    Abdullah N. Hisham

    2004-01-01

    Breast cancer is the most common cancer among Malaysian women. There is a marked geographical difference in the worldwide incidence of breast cancer, with a higher incidence in developed countries compared to developing countries. From 1998 to 2001, new cases of breast cancer presenting to the breast clinics at Hospital Kuala Lumpur and University Malaya Medical Centre, Malaysia, were reviewed; the race, age and stage at presentation were analysed. Of 774 cases seen in Hospital Kuala Lumpur, ...

  9. Availability and Overlap of Quality Computer Science Journal Holdings in Selected University Libraries in Malaysia

    OpenAIRE

    Zainab, A.N.; Ng, S.L.

    2003-01-01

    The study reveals the availability status of quality journals in the field of computer science held in the libraries of the University of Malaya, (UM), University of Science Malaysia (USM), University of Technology Malaysia (UTM), National University of Malaysia (UKM) and University Putra Malaysia (UPM). These universities are selected since they offer degree programmes in computer science. The study also investigates the degree of overlaps and unique titles in the five libraries. The Univers...

  10. Chinese literary works translated into Baba Malay: a bibliographical study

    OpenAIRE

    Yoong, S. K.; Zainab, A.N.

    2002-01-01

    Analyses 68 unique titles of Baba translated works published between 1889 and 1950. The titles are held in the libraries of the University of Malaya (UM), Science University Malaysia (USM), National University of Malaysia (UKM), the Dewan Bahasa dan Pustaka (DBP), National University of Singapore (NUS), National Library of Singapore (NLS) and the British Library (BL). The results reveal three periods of active publication of Baba translated works. A total of 18 works were translated before Wo...

  11. Addressing a silent killer - The International Conference on Betel Quid and Areca Nut

    Science.gov (United States)

    The Center for Global Health, National Cancer Institute, in coordination with the National Institute of Dental and Craniofacial Research , The University of Texas at MD Anderson Cancer Center, Oral Cancer Research Coordinating Center, University of Malaya, Taiwan Health Promotion Administration, Ministry of Health and Welfare, and with the generous support of the Malaysia Ministry of Health, hosted the International Conference on Betel Quid and Areca Nut in Kuala Lumpur Malaysia on April 27-28, 2016.

  12. 英領マラヤにおけるマレー人概念の土着化:スランゴル州におけるマレー人エリート層の形成

    OpenAIRE

    坪井祐司

    2011-01-01

    This article reconsiders the origins of the concept of “Malays” in British Malaya from the perspective of the colonial administration, focusing on the policy regarding the training of ethnic Malay administrative elites in the state of Selangor, which shows a variety of interaction between the British government and indigenous people centering around the framework of “Malayness”. The British introduced a framework of race to redefine the Malay people within its colonial administration, regardi...

  13. Laboratory Mass Production and Genetics of ’Anopheles Freeborni’

    Science.gov (United States)

    1990-07-19

    supplement, guinea pig and fish chow (Ralston Purina Co.), desiccated hog liver powder,-and brewer’s yeast (ICN Pharmaceuticals Inc). The dog food, hog...110 - .115 17 15.680 -.095 .064 ___39 36.034 -.090 .082 REFERENCES CITED Abbott , W. S. 1925. A method of computing the effectiveness of an insecticide...Trop. Med. 24:131-174. Reid, J. A. 1968. Anopheline mosquitoes of Malaya and Borneo. Stud. Inst. Med. Res. Malaysia , Kuala Lumpur. Reid, J. A. 1970

  14. Melioidosis in acute cholangitis of diabetic patient: a forgotten diagnosis

    OpenAIRE

    Mohamad, Nasir; Ponnusamy,Suresh; Devi,Sunita; Manikam,Rishya; Idrus,Ilya Irinaz; Hidayah Binti Abu Bakar,Nor

    2012-01-01

    Nasir Mohamad,1 Suresh Ponnusamy,2 Sunita Devi,3 Rishya Manikam,4 Ilya Irinaz Idrus,1 Nor Hidayah Abu Bakar51Department of Emergency Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia; 2AIMST University, Bedong, Malaysia; 3Hospital Sultan Abdul Halim, Sungai Petani, Malaysia; 4University Malaya Medical Centre, Kuala Lumpur, Malaysia; 5Department of Pathology, Hospital Raja Perempuan Zainab II, Kota Bharu, MalaysiaAbstract: Melioidosis presents with a wide...

  15. Government Can Mount Effective Counter-Insurgency Programs against Marxist Oriented Revolutions.

    Science.gov (United States)

    1983-09-01

    supported financially by the very people whom these arms and personnel are subjugating.3 An added taxation on the people’s resources creates a number...repre- sented by college students). 8 As these productive individuals are removed from the economy the effective taxation increase on the remaining...Malaya against Communist insurgency forces. When the British were requested to assist the Malaysian government, they took over the government

  16. Thermoluminescence dating studies at Gua Tok Long, Gunung Senyum, Temerloh, Pahang

    International Nuclear Information System (INIS)

    Rosli Mahat

    2004-01-01

    The paper discussed the thermoluminescence dating studies carried-out by the researchers from Physics Department, University Malaya. One of these dating studies was done at a cave of the mountain, Gua Tok Long, Gunung Senyum, Temerloh, Pahang, Malaysia. The result presents a straight line of Age vs Height graph. It shows the particulates and dirts of the cave atmosphere landed at constant rate on the cave floor without an erosion

  17. Revisiting the Life and Thought of Dr. Burhanuddin al-Helmy

    Directory of Open Access Journals (Sweden)

    Suzy Aziziyana Saili

    2013-06-01

    Full Text Available Burhanuddin al-Helmy is the least known name in Malaysian history. However, his role and thought cannot simply be dismissed although some of it were considered as controversial, and him be labelled as radical Malay leader. But one has to browse through his life and thought in order to determine his nature of being. Dr. Burhanuddin is a man of his time, experiencing the downside of British colonization and Japanese occupation. His personal experience in India and Palestine had shaped his conviction that Malaya and the Malay world need to be independent from the British rule. An active man in politics seen especially in his involvement in PKMM (Parti Kebangsaan Melayu Malaya and Parti Islam seTanah Melayu (PAS, but what is more important is his three most prevalent ideology. He stressed on Malay nationalism; he envision it as a nationalism for independence, humanity and well being; the idea of Greater Malaya; a unification with Indonesia in which he sees it as a political unification for all Malays in the Malay world, and; the influence of Malay rulers; which he is kind of sceptic towards the Malay sultan whom he viewed as jeopardizing the interests of the people.

  18. In vitro and in vivo anti-angiogenic activity of girinimbine isolated from Murraya koenigii

    Directory of Open Access Journals (Sweden)

    Iman V

    2015-03-01

    Full Text Available Venoos Iman,1 Hamed Karimian,1 Syam Mohan,2 Yahya Hasan Hobani,2 Mohamed Ibrahim Noordin,1 Mohd Rais Mustafa,3 Suzita Mohd Noor41Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Medical Research Center, University of Jazan, Jazan, Saudi Arabia; 3Department of Pharmacology, Centre for Natural Products and Drug Discovery (CENAR, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 4Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaAbstract: Girinimbine is a carbazole alkaloid isolated from the stem bark and root of Murraya koenigii. Here we report that girinimbine is an inhibitor of angiogenic activity both in vitro and in vivo. MTT results showed that girinimbine inhibited proliferation of human umbilical vein endothelial cells, while results from endothelial cell invasion, migration, tube formation, and wound healing assays demonstrated significant time- and dose-dependent inhibition by girinimbine. A proteome profiler array done on girinimbine-treated human umbilical vein endothelial cells showed that girinimbine had mediated regulation of pro-angiogenic and anti-angiogenic proteins. The anti-angiogenic potential of girinimbine was also evidenced in vivo in the zebrafish embryo model wherein girinimbine inhibited neo vessel formation in zebrafish embryos following 24 hours of exposure. Together, these results showed that girinimbine could effectively suppress angiogenesis, suggestive of its therapeutic potential as a novel angiogenesis inhibitor. Keywords: angiogenesis, inhibitor, carbazole alkaloid, zebrafish

  19. Developing an Independence State: Some Insights from Qalam Publication

    Directory of Open Access Journals (Sweden)

    Norziati Mohd Rosman

    2017-03-01

    Full Text Available This article is to identify a few concepts on independence and proposed a necessary approach in developing an identity of the country by analysing articles written in Qalam periodicals by three figures, Edrus, Dr Burhanuddin al-Helmy and Muhammad Isa Anshary. Qalam is a socio-politics periodical in Jawi script published in Singapore in 1950 until 1969. By analysing the writings, it is believed that proclamation of Indonesian independence in 1945 inspired to the development of Malaysia as a sovereign country and influenced readers in Malaya, Singapore and Brunei in which their countries were still struggling for independence.

  20. International Conference for Innovation in Biomedical Engineering and Life Sciences

    CERN Document Server

    Usman, Juliana; Mohktar, Mas; Ahmad, Mohd

    2016-01-01

    This volumes presents the proceedings of ICIBEL 2015, organized by the Centre for Innovation in Medical Engineering (CIME) under Innovative Technology Research Cluster, University of Malaya. It was held in Kuala Lumpur, Malaysia, from 6-8 December 2015. The ICIBEL 2015 conference promotes the latest researches and developments related to the integration of the Engineering technology in medical fields and life sciences. This includes the latest innovations, research trends and concerns, challenges and adopted solution in the field of medical engineering and life sciences. .

  1. The Experiences of Well-Being of Palliative Care Patients in Malaysia: A Thematic Analysis.

    Science.gov (United States)

    Beng, Tan Seng; Chin, Loh Ee; Guan, Ng Chong; Ann, Yee Hway; Wu, Cathie; Kuan, Wong Sook; Jane, Lim Ee; Khee, Saw Shier; Meng, Christopher Boey Chiong

    2015-08-01

    A qualitative study was conducted with semistructured interviews to explore the experiences of well-being in 15 adult palliative care inpatients of University Malaya Medical Center, Kuala Lumpur, Malaysia. The results were thematically analyzed. Six basic themes were generated (1) positive attitude, (2) positive cognitions, (3) positive emotions, (4) positive engagement, (5) positive relationships, and (6) positive circumstances. The Seeds Model was conceptualized from the analysis. This model may inform the development of interventions in the enhancement of well-being of palliative care patients. © The Author(s) 2014.

  2. The dental identification of victims of an aircraft accident in Malaysia.

    Science.gov (United States)

    Nambiar, P; Jalil, N; Singh, B

    1997-02-01

    On 15 September 1995 a Malaysian Airlines (MAS) Fokker 50 plane plunged while descending and crashed, killing thirty-four passengers aboard. The dental disaster victim identification team comprising dental surgeons from the Dental faculty, University of Malaya; Ministry of Health, Sabah; and the Malaysian Defence Forces played an active role in the identification process. Most of the bodies were badly mutilated, disfigured and severely incinerated. Problems were encountered due to inadequate facilities and space at the mortuary. Difficulties were also encountered during the procurement and deciphering of information from dental records. This disaster has however created greater awareness amongst Malaysians of the important role of forensic odontology in mass disasters.

  3. Inactivation of nuclear factor κB by MIP-based drug combinations augments cell death of breast cancer cells

    Directory of Open Access Journals (Sweden)

    Subramaniam M

    2018-05-01

    Full Text Available Menaga Subramaniam,1 Su Ki Liew,1 Lionel LA In,2 Khalijah Awang,3,4 Niyaz Ahmed,5 Noor Hasima Nagoor1,6 1Institute of Biological Science (Genetics & Molecular Biology, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia; 2Department of Biotechnology, Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia; 3Centre for Natural Product Research and Drug Discovery (CENAR, University of Malaya, Kuala Lumpur, Malaysia; 4Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia; 5Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, India; 6Centre for Research in Biotechnology for Agriculture (CEBAR, University of Malaya, Kuala Lumpur, Malaysia Background: Drug combination therapy to treat cancer is a strategic approach to increase successful treatment rate. Optimizing combination regimens is vital to increase therapeutic efficacy with minimal side effects. Materials and methods: In the present study, we evaluated the in vitro cytotoxicity of double and triple combinations consisting of 1'S-1'-acetoxychavicol acetate (ACA, Mycobacterium indicus pranii (MIP and cisplatin (CDDP against 14 various human cancer cell lines to address the need for more effective therapy. Our data show synergistic effects in MCF-7 cells treated with MIP:ACA, MIP:CDDP and MIP:ACA:CDDP combinations. The type of interaction between MIP, ACA and CDDP was evaluated based on combination index being <0.8 for synergistic effect. Identifying the mechanism of cell death based on previous studies involved intrinsic apoptosis and nuclear factor kappa B (NF-κB and tested in Western blot analysis. Inactivation of NF-κB was confirmed by p65 and IκBα, while intrinsic apoptosis pathway activation was confirmed by caspase-9 and Apaf-1 expression Results: All combinations confirmed intrinsic apoptosis activation and NF-κB inactivation. Conclusion: Double and triple

  4. Malaysian perceptions of China

    Directory of Open Access Journals (Sweden)

    Ibrahim Abu Bakar

    2009-11-01

    Full Text Available Malasia que consistía en Malaya, Sabah, Sarawak y Singapur ganó su independencia de los Británicos el 16 de septiembre de 1963. Malaya ganó su independencia de los británicos el 31 de agosto de 1957. En 1965 Singapur era independiente de Malasia. Malasia es una democracia parlamentaria y capitalista. Por otra parte, es una nación multi-religiosa y multirracial. Malasia ha sido poblada por los Malays, los Chinos, los Indios y otros. Los Malays son musulmanes y el Islam es la religión de la federación de Malasia. La nación tiene una larga historia con China pero esa nunca colonizó ningún área en Malasia. Los estados occidentales, fundamentalmente Portugueses y Olandeses colonizaron ciertas áreas en Malasia y luego los Británicos colonizaron la entera región. La percepción malasiana de China está influenciada por muchos factores internos y externos tales como el factor ideologico-político, el desarrollo económico así como las relaciones y la diplomacia nacionales, regionales e internacionales. Este breve artículo presenta la percepción malasiana de China desde un punto de vista cultural, político y económico._____________ABSTRACT:Malaysia consisting of Malaya, Sabah, Sarawak and Singapore gained her independence from the British on 16 September 1963. Malaya gained her independence from the British on 31 August 1957. In 1965 Singapore was independent from Malaysia. Malaysia is a parliamentary democratic and capitalistic nation. Moreover, Malaysia is a multi-religious and multiracial nation. Malaysia has been populated by the Malays, Chinese, Indians and others. The Malays are Muslims and Islam is the religion of the Federation of Malaysia. Malaysia has a very long history with China but China never colonized any area in Malaysia. The Western nations namely the Portuguese and the Dutch colonized certain areas in Malaysia and then the British colonized the whole Malaysia. Malaysian perceptions of China are influenced by many

  5. 3rd International Conference on Movement, Health and Exercise 2016

    CERN Document Server

    Cheong, Jadeera; Usman, Juliana; Ahmad, Mohd; Razman, Rizal; Selvanayagam, Victor

    2017-01-01

    This volume presents the proceedings of the 3rd International Conference on Movement, Health and Exercise 2016 (MoHE2016). The conference was jointly organized by the Biomedical Engineering Department and Sports Centre, University of Malaya. It was held in Malacca, from 28-30 September 2016. MoHE 2016 provided a good opportunity for speakers and participants to actively discuss about recent developments in a wide range of topics in the area of sports and exercise science. In total, 83 presenters and 140 participants took part in this successful conference. .

  6. The ABCDE of good care: A thematic analysis on the art of caring for terminally ill patients in Malaysia

    Directory of Open Access Journals (Sweden)

    Tan Seng Beng

    2017-04-01

    Full Text Available The first and foremost requisite of caring is to treat patients as persons, not as diseases or bed-numbers. A qualitative study was conducted to explore the perception of good care from the point of view of 13 terminally ill patientsand 8 caregiving family members of the University of Malaya Medical Centre, Kuala Lumpur, Malaysia. The results were thematically analyzed. Five basic themes were generated: (1 Attitude, (2 Behaviour, (3 Communication, (4 Duty and (5 Environment—ABCDE. The results may provide useful insight into the art of caring.

  7. Bibliographie

    OpenAIRE

    2014-01-01

    I. Sources A. Accords et traités 1. Agreement between Indonesia and Singapore in the Strait of Singapore, Jakarta, 25 May 1973. 2. Agreement between the Federation of Malaya, United Kingdom and Northern Ireland, North Borneo, Sarawak and Singapore, Kuala Lumpur, Government Print, 9 July 1963. 3. Agreement between the Government of Malaysia and the Government of the Republic of Singapore for avoidance of double taxation and the prevention of fiscal evasion with respect to tax income, Kuala Lum...

  8. Endoscopic Transsphenoidal Resection of Craniopharyngioma.

    Science.gov (United States)

    Liew, Kong Yew; Narayanan, Prepageran; Waran, Vicknes

    2018-02-01

    Objectives  To demonstrate, step-by-step, the technique and efficacy of endoscopic transsphenoidal approach in resection of a suprasellar craniopharyngioma. Design  The video shows a step-by-step approach to the resection, covering the exposure, access, resection, and confirmation of resection and reconstruction. Setting  The surgery was performed in the University of Malaya Medical Centre, a tertiary referral center in the capital of Malaysia. Participants  Surgery was performed jointly by Professor Prepageran from the department of otorhinolaryngology and Professor Vicknes Waran from the division of neurosurgery. Both surgeons are from the University of Malaya. Video compilation, editing, and voice narration was done by Dr. Kong Yew Liew. Main Outcome Measures  Completeness of resection and avoidance of intra- and postoperative complications. Results  Based on intraoperative views and MRI findings, the tumor was completely resected with the patient suffering only transient diabetes insipidus. Conclusion  Central suprasellar tumors can be removed completely via an endoscopic transsphenoidal approach with minimal morbidity to the patient. The link to the video can be found at: https://youtu.be/ZNIHfk12cYg .

  9. Implementation of Clinical Quality Management for Rehabilitation in Malaysia.

    Science.gov (United States)

    Engkasan, Julia Patrick; Stucki, Gerold; Ali, Sadeeq; Yusof, Yusniza Mohd; Hussain, Hafez; Latif, Lydia Abdul

    2018-04-18

    In February 2017, the World Health Organization (WHO) launched its historic "Rehabilitation 2030: A Call for Action". Scaling up rehabilitation in health systems requires concerted action across all 6 components of WHO's Health Systems Framework. For rehabilitation, information about functioning is essential, as it is required for effective rehabilitation at all levels of the health system. What is missing is a countrywide demonstration project involving the implementation of a clinical quality management system for the continuous improvement of rehabilitation, both at the level of clinical care for individual patients and at the level of rehabilitation service provision. Consequently, the Department of Rehabilitation Medicine at the University of Malaya and University Malaya Medical Centre, together with the Cheras Rehabilitation Hospital of the Ministry of Health, and the Social Security Organisation (SOCSO) Rehabilitation Centre in Malacca, Malaysia, initiated a project to develop a Malaysian-wide clinical quality management system for rehabilitation (CQM-R Malaysia). The objective of this paper is to describe CQM-R Malaysia. First, a conceptual description of a CQM-R based on the International Classification of Functioning, Disability and Health (ICF) is set out. The methods, results and conclusions of a situation analysis conducted in January 2017 are then reported. Finally, the building blocks and implementation action plan developed for CQM-R Malaysia are presented.

  10. Implementation of Clinical Quality Management for Rehabilitation in Malaysia

    Directory of Open Access Journals (Sweden)

    Julia Patrick Engkasan

    2017-11-01

    Full Text Available In February 2017, the World Health Organization (WHO launched its historic ”Rehabilitation 2030: A Call for Action”. Scaling up rehabilitation in health systems requires concerted action across all 6 components of WHO’s Health Systems Framework. For rehabilitation, information about functioning is essential, as it is required for effective rehabilitation at all levels of the health system. What is missing is a countrywide demonstration project involving the implementation of a clinical quality management system for the continuous improvement of rehabilitation, both at the level of clinical care for individual patients and at the level of rehabilitation service provision. Consequently, the Department of Rehabilitation Medicine at the University of Malaya and University Malaya Medical Centre, together with the Cheras Rehabilitation Hospital of the Ministry of Health, and the Social Security Organisation (SOCSO Rehabilitation Centre in Malacca, Malaysia, initiated a project to develop a Malaysian-wide clinical quality management system for rehabilitation (CQM-R Malaysia. The objective of this paper is to describe CQM-R Malaysia. First, a conceptual description of a CQM-R based on the International Classification of Functioning, Disability and Health (ICF is set out. The methods, results and conclusions of a situation analysis conducted in January 2017 are then reported. Finally, the building blocks and implementation action plan developed for CQM-R Malaysia are presented.

  11. Involvement of NF-ΚB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens

    Directory of Open Access Journals (Sweden)

    Ibrahim MY

    2014-11-01

    Full Text Available Mohamed Yousif Ibrahim,1 Najihah Mohd Hashim,1 Syam Mohan,2 Mahmood Ameen Abdulla,3 Siddig Ibrahim Abdelwahab,2 Behnam Kamalidehghan,1 Mostafa Ghaderian,1,4 Firouzeh Dehghan,1,5 Landa Zeenelabdin Ali,1 Hamed Karimian,1 Maizatulakmal Yahayu,6 Gwendoline Cheng Lian Ee,7 Abdoreza Soleimani Farjam,8 Hapipah Mohd Ali9 1Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Medical Research Centre, Jazan University, Jazan, Saudi Arabia; 3Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 4Epigenetics Lab, HIR Building, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia; 5Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 6Department of Bioproduct Research and Innovation, Institute of Bioproduct Development (IBD, Universiti Teknologi Malaysia, UTM Johor Bahru, Johor, Malaysia; 7Department of Chemistry, Faculty of Science, Universiti Putra Malaysia (UPM, Serdang, Selangor, Malaysia; 8Institute of Tropical Agriculture, Universiti Putra Malaysia (UPM, Serdang, Selangor, Malaysia; 9Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia Background: Cratoxylum arborescens has been used traditionally in Malaysia for the treatment of various ailments. Methods: α-Mangostin (AM was isolated from C. arborescens and its cell death mechanism was investigated. AM-induced cytotoxicity was observed with the 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT assay. Acridine orange/propidium iodide staining and annexin V were used to detect cells in early phases of apoptosis. High-content screening was used to observe the nuclear condensation, cell permeability, mitochondrial membrane potential, and cytochrome c release. The role of caspases-3/7, -8, and -9, reactive oxygen species, Bcl-2 and Bax expression, and cell cycle arrest were also investigated. To determine

  12. What influences patients’ acceptance of a blood pressure telemonitoring service in primary care? A qualitative study

    Directory of Open Access Journals (Sweden)

    Abdullah A

    2016-01-01

    Full Text Available Adina Abdullah,1 Su May Liew,1 Nik Sherina Hanafi,1 Chirk Jenn Ng,1 Pauline Siew Mei Lai,1 Yook Chin Chia,1 Chu Kiong Loo2 1Department of Primary Care Medicine, Faculty of Medicine, University Malaya Primary Care Research Group, University of Malaya, Kuala Lumpur, Malaysia; 2Department of Artificial Intelligence, Faculty of Computer Science and Information Technology, University of Malaya, Kuala Lumpur, Malaysia Background: Telemonitoring of home blood pressure (BP is found to have a positive effect on BP control. Delivering a BP telemonitoring service in primary care offers primary care physicians an innovative approach toward management of their patients with hypertension. However, little is known about patients’ acceptance of such service in routine clinical care.Objective: This study aimed to explore patients’ acceptance of a BP telemonitoring service delivered in primary care based on the technology acceptance model (TAM.Methods: A qualitative study design was used. Primary care patients with uncontrolled office BP who fulfilled the inclusion criteria were enrolled into a BP telemonitoring service offered between the period August 2012 and September 2012. This service was delivered at an urban primary care clinic in Kuala Lumpur, Malaysia. Twenty patients used the BP telemonitoring service. Of these, 17 patients consented to share their views and experiences through five in-depth interviews and two focus group discussions. An interview guide was developed based on the TAM. The interviews were audio-recorded and transcribed verbatim. Thematic analysis was used for analysis.Results: Patients found the BP telemonitoring service easy to use but struggled with the perceived usefulness of doing so. They expressed confusion in making sense of the monitored home BP readings. They often thought about the implications of these readings to their hypertension management and overall health. Patients wanted more feedback from their doctors and

  13. Glycemic control and antidiabetic drugs in type 2 diabetes mellitus patients with renal complications

    Directory of Open Access Journals (Sweden)

    Huri HZ

    2015-08-01

    Full Text Available Hasniza Zaman Huri,1,2 Lay Peng Lim,1 Soo Kun Lim3 1Department of Pharmacy, Faculty of Medicine, University of Malaya, 2Clinical Investigation Centre, University Malaya Medical Centre, 3Renal Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Background: Good glycemic control can delay the progression of kidney diseases in type 2 diabetes mellitus (T2DM patients with renal complications. To date, the association between antidiabetic agents and glycemic control in this specific patient population is not well established.Purpose: This study aimed to identify antidiabetic regimens as well as other factors that associated with glycemic control in T2DM patients with different stages of chronic kidney disease (CKD.Patients and methods: This retrospective, cross-sectional study involved 242 T2DM inpatients and outpatients with renal complications from January 2009 to March 2014 and was conducted in a tertiary teaching hospital in Malaysia. Glycated hemoglobin (A1C was used as main parameter to assess patients’ glycemic status. Patients were classified to have good (A1C <7% or poor glycemic control (A1C ≥7% based on the recommendations of the American Diabetes Association.Results: Majority of the patients presented with CKD stage 4 (43.4%. Approximately 55.4% of patients were categorized to have poor glycemic control. Insulin (57.9% was the most commonly prescribed antidiabetic medication, followed by sulfonylureas (43%. Of all antidiabetic regimens, sulfonylureas monotherapy (P<0.001, insulin therapy (P=0.005, and combination of biguanides with insulin (P=0.038 were found to be significantly associated with glycemic control. Other factors including duration of T2DM (P=0.004, comorbidities such as anemia (P=0.024 and retinopathy (P=0.033, concurrent medications such as erythropoietin therapy (P=0.047, a-blockers (P=0.033, and antigouts (P=0.003 were also correlated with A1C.Conclusion: Identification of

  14. The development and validation of the Satisfaction Questionnaire for Osteoporosis Prevention in Malaysia

    Directory of Open Access Journals (Sweden)

    Toh LS

    2014-09-01

    Full Text Available Li Shean Toh,1 Pauline Siew Mei Lai,2 David Bin-Chia Wu,3 Kok Thong Wong,1 Bee Yean Low,1 Alexander Tong Boon Tan,4 Claire Anderson5 1School of Pharmacy, University of Nottingham, Semenyih, Malaysia; 2Department of Primary Care Medicine, University of Malaya Primary Care Research Group, University of Malaya, Kuala Lumpur, Malaysia; 3School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia; 4Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 5Division of Social Research in Medicine and Health, School of Pharmacy, University of Nottingham, Nottingham, UK Purpose: To develop and validate the English version of the Satisfaction Questionnaire for Osteoporosis Prevention (SQOP in Malaysia.Methods: The SQOP was modified from the Osteoporosis Patient Satisfaction Questionnaire and developed based on literature review and patient interviews. Face and content validity were established via an expert panel. The SQOP consists of two sections: clinical services and types of counseling. There were 23 items in total, each with a five-point Likert-type response. Satisfaction score was calculated by converting the total score to a percentage. A higher score indicates higher satisfaction. English speaking, non-osteoporotic, postmenopausal women aged ≥50 years were included in the study. Participants were randomized to either the control or intervention group. Intervention participants were provided counseling, whereas control participants received none. Participants answered the SQOP at baseline and 2 weeks later.Results: A total of 140 participants were recruited (control group: n=70; intervention group: n=70. No significant differences were found in any demographic aspects. Exploratory factor analysis extracted seven domains. Cronbach’s a for the domains ranged from 0.531–0.812. All 23 items were highly correlated using Spearman’s correlation coefficient 0.469–0.996 (P<0.05, with no significant change in the control

  15. Evidence of the gastroprotective and anti-Helicobacter pylori activities of β-mangostin isolated from Cratoxylum arborescens (vahl blume

    Directory of Open Access Journals (Sweden)

    Sidahmed HMA

    2016-01-01

    Full Text Available Heyam Mohamed Ali Sidahmed,1 Najihah Mohd Hashim,1 Syam Mohan,2 Siddig Ibrahim Abdelwahab,2 Manal Mohamed Elhassan Taha,2 Firouzeh Dehghan,3 Maizatulakmal Yahayu,4 Gwendoline Cheng Lian Ee,5 Mun Fai Loke,6 Jamuna Vadivelu6 1Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Medical Research Center, Jazan University, Jazan, Saudi Arabia; 3Department of Exercise Science, Sports Centre, University of Malaya, Kuala Lumpur, 4Department of Bioproduct Research and Innovation, Institute of Bioproduct Development (IBD, Universiti Teknologi Malaysia (UTM, Johor Bahru, 5Department of Chemistry, Faculty of Science, Universiti Putra Malaysia (UPM, Serdang, 6Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Purpose: β-Mangostin (BM from Cratoxylum arborescens demonstrated various pharmacological activities such as anticancer and anti-inflammatory. In this study, we aimed to investigate its antiulcer activity against ethanol ulcer model in rats. Materials and methods: BM was isolated from C. arborescens. Gastric acid output, ulcer index, gross evaluation, mucus production, histological evaluation using hematoxylin and eosin and periodic acid–Schiff staining and immunohistochemical localization for heat shock protein 70 (HSP70 and Bax proteins were investigated. Possible involvement of reduced glutathione, lipid peroxidation, prostaglandin E2, antioxidant enzymes, superoxide dismutase and catalase enzymes, radical scavenging, nonprotein sulfhydryl compounds, and anti-Helicobacter pylori were investigated. Results: BM showed antisecretory activity against the pylorus ligature model. The pretreatment with BM protect gastric mucosa from ethanol damaging effect as seen by the improved gross and histological appearance. BM significantly reduced the ulcer area formation, the submucosal edema, and the leukocytes infiltration compared to the ulcer control. The compound

  16. The mediating role of psychological symptoms on falls risk among older adults with osteoarthritis

    Directory of Open Access Journals (Sweden)

    Mat S

    2017-11-01

    Full Text Available Sumaiyah Mat,1 Chin Teck Ng,1–3 Farhana Fadzil,4 Faizatul Izza Rozalli,4 Maw Pin Tan1,5 1Ageing and Age-Associated Disorders Research Group, University of Malaya, Kuala Lumpur, Malaysia; 2Department of Rheumatology and Immunology, Singapore General Hospital, 3Duke-NUS Medical School, National University Singapore, Singapore; 4Department of Radiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 5Geriatric Division, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Abstract: The purpose of this study was to investigate the role of fear of falling (FoF and psychological symptoms in explaining the relationship between osteoarthritis (OA symptom severity and falls. Individuals aged ≥65 years with ≥2 falls or ≥1 injurious fall over the past 12 months were included in the falls group, while volunteers aged ≥65 years with no history of falls over 12 months were recruited as controls. The presence of lower extremity OA was determined radiologically and clinically. Severity of symptoms was assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC questionnaire. FoF and psychological status were measured with the shortened version of the Falls Efficacy Scale-International and the 21-item Depression, Anxiety and Stress Scale (DASS-21, respectively. Of 389 (229 fallers, 160 non-fallers potential participants, mean (SD age: 73.74 (6.60 years, 141 had clinical OA and 171 had radiological OA. Fallers with both radiological OA and clinical OA had significantly higher FoF and DASS-21 scores than non-fallers. FoF was significantly positively correlated with symptom severity in fallers and non-fallers with radiological and clinical OA. Depression, anxiety, and stress scores were only significantly correlated with symptom severity among fallers but not non-fallers in both clinical and radiological OA. The relationship between mild symptoms and reduced risk of falls

  17. The apoptotic effects of Brucea javanica fruit extract against HT29 cells associated with p53 upregulation and inhibition of NF-κB translocation

    Directory of Open Access Journals (Sweden)

    Bagheri E

    2018-03-01

    Full Text Available Elham Bagheri,1 Fatemeh Hajiaghaalipour,2 Shaik Nyamathulla,1 Nur’Ain Salehen3 1Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Institute of Biological Science, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia; 3Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Background: Brucea javanica (L. Merr. is a plant from the genus Brucea, which is used in local traditional medicine to treat various diseases. Recent studies revealed an impressive anticancer efficiency of B. javanica extract in different types of cancer cells.Purpose: In this study, we have investigated the cytotoxic effects of the B. javanica hexane, ethanolic extracts against colon cancer cells. HT29 colon cells were selected as an in vitro cancer model to evaluate the anticancer activity of B. javanica ethanolic extract (BJEE and the possible mechanisms of action that induced apoptosis.Methods: 3-(4,5-dimethylthiazol-2-yl-2, 5,-diphenyltetrazolium bromide (MTT, lactate dehydrogenase, acridine orange/propidium iodide, and annexin-V-fluorescein isothiocyanate assays were performed to determine the antiproliferative and apoptosis validation of BJEE on cancer cells. Measurement of reactive oxygen species (ROS production, caspase activities, nucleus factor-κB activity, and gene expression experiments was done to investigate the potential mechanisms of action in the apoptotic process.Results: The results obtained from this study illustrated the significant antiproliferative effect of BJEE on colorectal cancer cells, with a concentration value that inhibits 50% of the cell growth of 25±3.1 µg/mL after 72 h of treatment. MTT assay demonstrated that the BJEE is selectively toxic to cancer cells, and BJEE induced cell apoptosis via activation of caspase-8 along with modulation of apoptosis-related proteins such as Fas, CD40, tumor necrosis factor-related apoptosis-inducing ligands

  18. Leong, K.M. (Ed.). The Petroleum Geology and Resources of Malaysia ISBN 983-9738-10-0 . Petronas (Petroliam Nasional Berhad), Kualar Lumpur 2000, A4 size, 665 pages (U.S. $100 + postage (2.5 kg)), hyperlinkhttp://www.petronas.com.my

    Science.gov (United States)

    Murphy, Richard W.; Hutchison, Charles S.

    2001-08-01

    This 27-chapter volume is a comprehensive review of the petroleum geology of a significant Southeast Asian oil-producing country. The authors are predominantly from Petronas (20) with contributions by Shell (2) and the University of Malaya (1). The whole manuscript was reviewed by Dick Selley and coordinated by Leong Khee Meng. Foremost among the authors is Dr Mazlan Hj. Madon, whose byline is found on 14 chapters and whose guiding hand can be recognised throughout the book. In addition to in-house reports, Petronas has drawn on oil company work, resulting both from exploration activities on PSCs and from regional assessments, based on public domain and proprietary data. The companies involved include Esso, Shell, Mobil, Sun, Texaco, Conoco, Oxy, Triton, OPIC, Idemitsu, Nippon Oil, Elf, Hall-Houston and Western Mining. The volume is a remarkable tribute to the progress made by the Malaysian National Oil Company in the 25 years since the granting of its initial charter in 1974.

  19. Book Reviews

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    William R. Roff

    1970-07-01

    Full Text Available - Jane Bunnag, Hans-Dieter Evers, Loosely structured social systems: Thailand in comparative perspective. Cultural Report Series no. 17, Yale University Southeast Asia Studies. New Haven 1969. 148 pp. - L. Sluimers, Milton E. Osborne, The French presence in Cochin-China and Cambodia: Rule and response (1859-1905. Cornell University Press, Ithaca and London 1970. XVIII + 379 pp. - H.J. Duller, G.L. Hicks, The Indonesian economy, 1950-1965; met een supplement tot 1967. Bibliographical Series No. 9, South-East Asia Studies, Yale University 1967. 248 p., n.p., G. McNicoll (eds. - J.W. de Vries, A. Mörzer Bruyns, Kamus singkatan dan akronim yang dipergunakan di Indonesia/Glossary of abbreviations and acronyms used in Indonesia, Ichtiar, Djakarta 1970. - William R. Roff, Abdul Majid Mohamed Mackeen, Contemporary Islamic legal organization in Malaya. Monograph Series No. 13. Yale University Southeast Asia Studies, New Haven, 1969. vii + 79 + 55 pp.

  20. Revolution in the natural gas industry?

    International Nuclear Information System (INIS)

    Thomas, V.

    1999-01-01

    The demand for cleaner automotive fuels has created an opening for converting natural gas to liquid transport fuels and blending agents using Fischer-Tropsch technology. While the technology is well established, it is not yet clear whether the conversion can compete with crude oil refining or with pipelines and liquefied natural gas. Although all the oil giants are interested in the technology, the only commercial-sized plant in the world was the Shell plant in Malaya which had capacity of 12,000 bpd, but the profitability of the plant came from the wax by-products. The plant has been closed since a fire and explosion in 1997. The process chain is described. The gas-to-liquid activities and achievements of Saol, Exxon and Texaco are reported. It was concluded that although there are still some problems to be ironed-out, there is a promising future for gas-to-liquid conversion. (UK)

  1. LA TURQUIE AU DEBUT DE CHEMIN 1919 - 1923

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    Ionuţ COJOCARU

    2010-11-01

    Full Text Available Decline of the Ottoman Empire has used its last sta ge when World War I until the proclamation of the Republic of Turkey on October 29, 1923. Political and social changes have marked the country into two camps: supporters of the Sultanate and the nationalists led by Mustafa Kemal. Lasting conflict, both the Greeks and the Franco-British nationalists have gained ground and tilted the scales in their favor to end dynasty succeeded Osman. On the morning of November 17, last Sultan and his son ascended the British ship "Malaya" and fled. After the conflict, the Turks were invited to Lausanne where they were presented to winners. From this position they began negotiations. For Romania, the Convention in its final form became beneficial, because our perspective was adopted, and our interest to take the path through the straits has been approved.

  2. Additions and corrections to the cadastre of Orthoptera insects of Samarskaya Luka, on the basis of analysis of acoustic signals of males

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    Alexander А. Benediktov

    2017-08-01

    Full Text Available For the territory of Samarskaya Luka, at the village Bakhilova Polyana (I.I. Sprygin Zhiguli State Natural Biosphere Reserve, 25 species of Orthoptera were found in mid-July 2016. These species were identified basically by the analysis of male acoustic signals. This is 44% of the total species composition of Samarskaya Luka Orthoptera, specified in the Cadastre of invertebrates of Samarskaya Luka. The specimens belonging to the grasshopper Platychleis albopunctata (= P. intermedia auct. are clarified. The cricket Melanogryllus desertus and the locust Chorthippus dorsatus were found for the first time in the Samarskaya Luka. The species composition of the cryptic taxa of the «Chorthippus biguttulus group» of the Middle Volga region is discussed. Based on the unstable amplitude-time structure of the signals of the supposed Ch. biguttulus males from Malaya Bahilova Mountain, it is assumed that they may have a hybrid origin.

  3. Encouraging a 'Barrier-free Built Environment' in a Malaysian University

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    Hazreena Hussein

    2005-12-01

    Full Text Available A good pedestrian network around the campus should be accessible and friendly for all users including disabled persons. The environment should offer some activity nodes to ensure that the learning and working in campus is more pleasant. The paper will clarify the importance of collaborative development among various professionals and organisations in order to achieve a 'barrier-free built environment', focusing on the University of Malaya as a case study. It will share experience on the education of inclusive design for students who will become professionals and responsible in implementing the legislation relating to safety, accessibility and usability of the built environment. As the objective is the issue of educating relevant professionals, it will introduce methods in teaching professionals as a strategy to advocate a 'barrier-free built environment'. The paper will also illustrate the efforts done in encouraging the agenda which have been implemented around the case study.

  4. KOSTERMANSIA SOEGENG A NEW GENUS IN BGMBACACEAE (Durioneae*

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    W. SOEGENG REKSODIHARDJO

    1959-06-01

    Full Text Available In working up the genus Coelostegia, I received on loan from the ForestResearch Institute at Kepong, Malaya abundant material of a species whichWyatt-Smith was unable to place. Dr. Kostermans pointed out to me thatmost likely the specimens belonged to a new genus, related to CoelostegiaI have taken the liberty to name the genus after Dr. A. J. G. H. Kostermanswho has been devoting time and energy teaching me taxonomy, and whoJias taken up the burden of the development of taxonomic botany in In-donesia.I am indebted to Prof. Dr. C. G. G. J. van Steenis and to Dr. R. GBakhuizen van den Brink Jr., who have kindly helped me in preparing theLatin diagnoses.

  5. Malaysia's Education Policies and the Law of Unintended Consequences

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    Kee-Cheok Cheong

    2016-10-01

    Full Text Available Since gaining independence in 1957, the Federation of Malaya and now Malaysia has implemented education policies to broaden access, to unify an ethnically diverse population through a common curriculum and language, to enable the disadvantaged to catch up through affirmative action, and to build human capital as the country seeks to become an advanced country in the face of globalization. While some policies, such as enhancing access have achieved their objectives, others, such as unification and development of a national identity, have not. No less important are the unintended consequences of these policies. While some, like the expansion of private higher education and transnational higher education, have been a boon to Malaysian education, others, such as ethnic polarization in education, have been damaging. Some of these consequences, while unintended, have not been unexpected.

  6. Knowledge portal: a tool to capture university requirements

    Science.gov (United States)

    Mansourvar, Marjan; Binti Mohd Yasin, Norizan

    2011-10-01

    New technologies, especially, the Internet have made a huge impact on knowledge management and information dissemination in education. The web portal as a knowledge management system is very popular topics in many organizations including universities. Generally, a web portal defines as a gateway to online network accessible resources through the intranet, extranet or Internet. This study develops a knowledge portal for the students in the Faculty of Computer Science and Information Technology (FCSIT), University of Malaya (UM). The goals of this portal are to provide information for the students to help them to choose the right courses and major that are relevant to their intended future jobs or career in IT. A quantitative approach used as the selected method for this research. Quantitative method provides an easy and useful way to collect data from a large sample population.

  7. The grotesque female in Malaysian poems: shaping the migrant's psyche.

    Science.gov (United States)

    DMani, Sheba

    2011-12-01

    The works of Malaysian poet, Wong Phui Nam's Against the Wilderness (vii) China bride and Variations on a Birthday Theme (iv) Kali, illustrate a bride and a mother in terrifying images. Wong's stylistic form of representing the female body through startling images of inversion and degradation evoke feelings of unease. The suspension between the known and the unknown causes a bewildering reality verging on madness. Interpreted through the lens of the carnivalesque, specifically, the grotesque body, festive language and parody, I attempt to reconstruct the psyche of the Chinese migrant which underpins these poems. The migrant who arrived in Malaya during the colonial era in the early nineteenth century faced political and social struggles in adapting to a new land. In the poems, the migrant juxtaposes his position to a female and uses the female body as a site of contention to intensify the torment of the psyche and to reflect the despair of the Chinese in Malaysia.

  8. Factorial validity and reliability of the Malaysian simplified Chinese version of Multidimensional Scale of Perceived Social Support (MSPSS-SCV) among a group of university students.

    Science.gov (United States)

    Guan, Ng Chong; Seng, Loh Huai; Hway Ann, Anne Yee; Hui, Koh Ong

    2015-03-01

    This study was aimed at validating the simplified Chinese version of the Multidimensional Scale of Perceived Support (MSPSS-SCV) among a group of medical and dental students in University Malaya. Two hundred and two students who took part in this study were given the MSPSS-SCV, the Medical Outcome Study social support survey, the Malay version of the Beck Depression Inventory, the Malay version of the General Health Questionnaire, and the English version of the MSPSS. After 1 week, these students were again required to complete the MSPSS-SCV but with the item sequences shuffled. This scale displayed excellent internal consistency (Cronbach's α = .924), high test-retest reliability (.71), parallel form reliability (.92; Spearman's ρ, P students. It could therefore be used as a simple screening tool among young educated Malaysian adolescents. © 2013 APJPH.

  9. Behavior Intention To Use Of Learning Management System Among Malaysian Pre-Service Teachers: A Confirmatory Factor Analysis

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    Sousan Baleghi-Zadeh

    2014-01-01

    Full Text Available Learning Management system is a type of Information system that many universities invest on to be integrated with their curriculum. Therefore, factors which make students accept or reject Learning Management System is crucial for educational managers of universities. The main purpose of the present study is to modify and validate a measurement model based on two models of Technology Acceptance Model and Fit Model. The proposed measurement model included five constructs of perceived ease of use, perceived usefulness, behavior intention to use, technical support and task-technology fit. The sample size of the study was 300 pre-service teachers studying at Universiti Putra Malaysia (UPM and Universiti of Malaya (UM. The results of the study revealed that after deleting eleven items, the proposed measurement model was validated and fit. Therefore, the modified measurement model was able to present the theoretical patterns of the actual data.

  10. Human Behaviour and Responses Challenge towards Emergence of Infectious Diseases: E.coli clinical isolate

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    Ummi Mohlisi Mohd Asmawi

    2016-01-01

    Full Text Available Consumption of undercooked ground beef is the most common route of transmission of verotoxin-producing E.coli. It is estimated that non-O157 verotoxigenic E.coli (VTEC can cause diarrhea.The sample was isolated from Universiti Malaya Medical Centre. All the isolates were identified using agarose gel electrophoresis method. This study aims to detect the verotoxin genes and detect the link or involvement of plasmids with these verotoxin genes. Therefore, this study will contribute to shed new light on resolving the significant and global problem of diarrheal disease caused by this particular pathogenic organism and help in improvising novel therapeutic approaches to improve human healthcare.

  11. Pythons in Burma: Short-tailed python (Reptilia: Squamata)

    Science.gov (United States)

    Zug, George R.; Gotte, Steve W.; Jacobs, Jeremy F.

    2011-01-01

    Short-tailed pythons, Python curtus species group, occur predominantly in the Malayan Peninsula, Sumatra, and Borneo. The discovery of an adult female in Mon State, Myanmar, led to a review of the distribution of all group members (spot-mapping of all localities of confirmed occurrence) and an examination of morphological variation in P. brongersmai. The resulting maps demonstrate a limited occurrence of these pythons within peninsular Malaya, Sumatra, and Borneo with broad absences in these regions. Our small samples limit the recognition of regional differentiation in the morphology of P. brongersmai populations; however, the presence of unique traits in the Myanmar python and its strong allopatry indicate that it is a unique genetic lineage, and it is described as Python kyaiktiyo new species.

  12. Soft skills and dental education.

    Science.gov (United States)

    Gonzalez, M A G; Abu Kasim, N H; Naimie, Z

    2013-05-01

    Soft skills and hard skills are essential in the practice of dentistry. While hard skills deal with technical proficiency, soft skills relate to a personal values and interpersonal skills that determine a person's ability to fit in a particular situation. These skills contribute to the success of organisations that deal face-to-face with clients. Effective soft skills benefit the dental practice. However, the teaching of soft skills remains a challenge to dental schools. This paper discusses the different soft skills, how they are taught and assessed and the issues that need to be addressed in their teaching and assessment. The use of the module by the Faculty of Dentistry, University of Malaya for development of soft skills for institutions of higher learning introduced by the Ministry of Higher Education, Malaysia. © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.

  13. Historical development of the renal histopathology services in Malaysia.

    Science.gov (United States)

    Looi, Lai-Meng; Cheah, Phaik-Leng

    2009-06-01

    Western-style medicine was introduced to Malaya by the Portuguese, Dutch and British between the 1500s and 1800s. Although the earliest pathology laboratories were developed within hospitals towards the end of the 19th Century, histopathology emerged much later than the biochemistry and bacteriology services. The University Departments of Pathology were the pioneers of the renal histopathology diagnostic services. The Department of Pathology, University of Malaya (UM) received its first renal biopsy on 19 May 1968. Hospital Universiti Kebangsaan Malaysia (HUKM) and Hospital Universiti Sains Malaysia (HUSM) started their services in 1979 and 1987 respectively. It is notable that the early services in these University centres caterred for both the university hospitals and the Ministry of Health (MOH) until the mid-1990s when MOH began to develop its own services, pivoted on renal pathologists trained through Fellowship programmes. Currently, key centres in the MOH are Kuala Lumpur Hospital, Sultanah Aminah Hospital Johor Bahru and Malacca Hospital. With the inclusion of renal biopsy interpretation in the Master of Pathology programmes, basic renal histopathology services became widely available throughout the country from 2000. This subsequently filtered out to the private sector as more histopathologists embraced private practice. There is now active continuing professional development in renal histopathology through clinicopathological dicussions, seminars and workshops. Renal research on amyloid nephropathy, minimal change disease, IgA nephropathy, fibrillary glomerulonephritis, lupus nephritis and microwave technology have provided an insight into the patterns of renal pathology and changing criteria for biopsy. More recently, there has been increasing involvement of renal teams in clinical trials, particularly for lupus nephritis and renal transplant modulation.

  14. Suicide and ethnicity in Malaysia.

    Science.gov (United States)

    Murty, Om Prakash; Cheh, Lo Boon; Bakit, Pangie Anak; Hui, Foo Jhi; Ibrahim, Zarina Binti; Jusoh, Nazirah Binti

    2008-03-01

    This article highlights methods of ending life in different ethnic groups. This inference is drawn from analysis of data from suicidal cases from the University Malaya Medical Centre mortuary. This study also looked at sex, age, social, and employment factors. Kuala Lumpur has sizeable populations of Muslims, Chinese, Indians and Indonesian, etc. This study is based on 251 cases of suicide that were reported at the University Malaya Medical Centre from 2000 to 2004. Malaysia has a population of 22,662,365 people with 3 major ethnic groups: Malay (58%), Chinese (24%), and Indians (8%) with a minority of "others" (10%), which includes foreigners, Sabahan, and Sarawakian. This research found suicides of 164 male (65%) and 87 female (35%) victims. Their age ranged from 15 to 80 years. The age group from 21 to 30 had the highest total cases of suicide (83 of 251; 33.1%). Among ethnic groups highest rate of suicide was among Chinese with a total of 120 cases (120 of 251; 47.8%). As far as lone method of suicide is concerned, hangings accounted for the highest proportion of cases (108 of 251; 43%). Among ethnic groups, jumping from height was the commonest method used by Chinese (49 of 120; 41%), Malay (9 of 16; 56%), and others (15 of 28; 53.4%); whereas, hanging was the commonest method of committing suicide by Indians (49 of 87); Muslims showed the lowest cases of suicide (18 of 251; 7.2%). In poisoning group Indian was the highest ethnic group who used this method (20 of 37; 54.1%).

  15. Overview of Breast Cancer in Malaysian Women: A Problem with Late Diagnosis

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    Abdullah N. Hisham

    2004-04-01

    Full Text Available Breast cancer is the most common cancer among Malaysian women. There is a marked geographical difference in the worldwide incidence of breast cancer, with a higher incidence in developed countries compared to developing countries. From 1998 to 2001, new cases of breast cancer presenting to the breast clinics at Hospital Kuala Lumpur and University Malaya Medical Centre, Malaysia, were reviewed; the race, age and stage at presentation were analysed. Of 774 cases seen in Hospital Kuala Lumpur, only 5.2% (40/774 were impalpable breast cancers diagnosed on mammography. The prevalent age group was 40 to 49 years, and the median age was 50 years. The average size of the tumour was 5.4 cm in diameter. Malay women appear to have larger tumours and a later stage at presentation than other ethnic groups; 50% to 60% were in late stages (Stages 3 and 4. During the same period, 752 new cases of breast cancer were seen in the University Malaya Medical Centre. The average tumour size was 4.2 cm, and 30% to 40% were in late stages. The age incidence was similar. The delay in presentation of breast cancer was attributed to a strong belief in traditional medicine, the negative perception of the disease, poverty and poor education, coupled with fear and denial. A prospective, population-based study is required to determine the demographic pattern of breast cancer and the factors delaying presentation. These findings will have important implications in future programmes to promote the early detection of breast cancer, as well as in understanding geographical as well as racial variations in the incidence of breast cancer.

  16. Association of psychological factors, patients’ knowledge, and management among patients with erectile dysfunction

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    Huri HZ

    2016-05-01

    Full Text Available Hasniza Zaman Huri,1,2 Nurul Diyana Mat Sanusi,1 Azad Hassan Abdul Razack,3 Raymond Mark1 1Department of Pharmacy, 2Clinical Investigation Center, University of Malaya Medical Centre, 3Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Background: Erectile dysfunction (ED is one of the most common health problems in men. ED can significantly affect a man’s psychological well-being and overall health. Purpose: To investigate the association of psychological factors, patients’ knowledge, and management among ED patients. Patients and methods: A total of 93 patients with an age range from 31 to 81 years who have undergone treatment for ED were included in this study. Results: It was found that the feeling of blame (P=0.001, guilt (P=0.001, anger or bitterness (P=0.001, depression (P=0.001, feeling like a failure (P=0.001, and the feeling of letting down a partner during intercourse (P=0.001 were significantly associated with ED. Age was also found to be significantly associated with patients’ psychological scale (P=0.004. In addition, the majority of patients in this study practice the right method of administration of ED therapy. However, no significant correlation was found between patients’ knowledge of ED therapy and demographic characteristics. Conclusion: This study concluded that ED does affect psychological well-being of people. In addition, patient’s knowledge about ED and its management is also crucial in ensuring that the patient achieves optimal therapeutic outcomes from ED therapy. Keywords: erectile dysfunction, psychological factors, patients’ knowledge, management

  17. Examining the relationship between local extinction risk and position in range.

    Science.gov (United States)

    Boakes, Elizabeth H; Isaac, Nicholas J B; Fuller, Richard A; Mace, Georgina M; McGowan, Philip J K

    2018-02-01

    Over half of globally threatened animal species have experienced rapid geographic range loss. Identifying the parts of species' distributions most vulnerable to local extinction would benefit conservation planning. However, previous studies give little consensus on whether ranges decline to the core or edge. We built on previous work by using empirical data to examine the position of recent local extinctions within species' geographic ranges, address range position as a continuum, and explore the influence of environmental factors. We aggregated point-locality data for 125 Galliform species from across the Palearctic and Indo-Malaya into equal-area half-degree grid cells and used a multispecies dynamic Bayesian occupancy model to estimate rates of local extinctions. Our model provides a novel approach to identify loss of populations from within species ranges. We investigated the relationship between extinction rates and distance from range edge by examining whether patterns were consistent across biogeographic realm and different categories of land use. In the Palearctic, local extinctions occurred closer to the range edge than range core in both unconverted and human-dominated landscapes. In Indo-Malaya, no pattern was found for unconverted landscapes, but in human-dominated landscapes extinctions tended to occur closer to the core than the edge. Our results suggest that local and regional factors override general spatial patterns of recent local extinction within species' ranges and highlight the difficulty of predicting the parts of a species' distribution most vulnerable to threat. © 2017 The Authors. Conservation Biology published by Wiley Periodicals, Inc. on behalf of Society for Conservation Biology.

  18. Challenges of Treating Childhood Medulloblastoma in a Country With Limited Resources: 20 Years of Experience at a Single Tertiary Center in Malaysia.

    Science.gov (United States)

    Rajagopal, Revathi; Abd-Ghafar, Sayyidatul; Ganesan, Dharmendra; Bustam Mainudin, Anita Zarina; Wong, Kum Thong; Ramli, Norlisah; Jawin, Vida; Lum, Su Han; Yap, Tsiao Yi; Bouffet, Eric; Qaddoumi, Ibrahim; Krishnan, Shekhar; Ariffin, Hany; Abdullah, Wan Ariffin

    2017-04-01

    Pediatric medulloblastoma (MB) treatment has evolved over the past few decades; however, treating children in countries with limited resources remains challenging. Until now, the literature regarding childhood MB in Malaysia has been nonexistent. Our objectives were to review the demographics and outcome of pediatric MB treated at the University Malaya Medical Center between January 1994 and December 2013 and describe the challenges encountered. Fifty-one patients with childhood MB were seen at University Malaya Medical Center. Data from 43 patients were analyzed; eight patients were excluded because their families refused treatment after surgery. Headache and vomiting were the most common presenting symptoms, and the mean interval between symptom onset and diagnosis was 4 weeks. Fourteen patients presented with metastatic disease. Five-year progression-free survival (± SE) for patients ≥ 3 years old was 41.7% ± 14.2% (95% CI, 21.3% to 81.4%) in the high-risk group and 68.6% ± 18.6% (95% CI, 40.3% to 100%) in the average-risk group, and 5-year overall survival (± SE) in these two groups was 41.7% ± 14.2% (95% CI, 21.3% to 81.4%) and 58.3% ± 18.6% (95% CI, 31.3% to 100%), respectively. Children younger than 3 years old had 5-year progression-free and overall survival rates (± SE) of 47.6% ± 12.1% (95% CI, 28.9% to 78.4%) and 45.6% ± 11.7% (95% CI, 27.6% to 75.5%), respectively. Time to relapse ranged from 4 to 132 months. Most patients who experienced relapse died within 1 year. Febrile neutropenia, hearing loss, and endocrinopathy were the most common treatment-related complications. The survival rate of childhood MB in Malaysia is inferior to that usually reported in the literature. We postulate that the following factors contribute to this difference: lack of a multidisciplinary neuro-oncology team, limited health care facilities, inconsistent risk assessment, insufficient data in the National Cancer Registry and pathology reports, inadequate long

  19. Challenges of Treating Childhood Medulloblastoma in a Country With Limited Resources: 20 Years of Experience at a Single Tertiary Center in Malaysia

    Directory of Open Access Journals (Sweden)

    Revathi Rajagopal

    2017-04-01

    Full Text Available Purpose: Pediatric medulloblastoma (MB treatment has evolved over the past few decades; however, treating children in countries with limited resources remains challenging. Until now, the literature regarding childhood MB in Malaysia has been nonexistent. Our objectives were to review the demographics and outcome of pediatric MB treated at the University Malaya Medical Center between January 1994 and December 2013 and describe the challenges encountered. Methods: Fifty-one patients with childhood MB were seen at University Malaya Medical Center. Data from 43 patients were analyzed; eight patients were excluded because their families refused treatment after surgery. Results: Headache and vomiting were the most common presenting symptoms, and the mean interval between symptom onset and diagnosis was 4 weeks. Fourteen patients presented with metastatic disease. Five-year progression-free survival (± SE for patients ≥ 3 years old was 41.7% ± 14.2% (95% CI, 21.3% to 81.4% in the high-risk group and 68.6% ± 18.6% (95% CI, 40.3% to 100% in the average-risk group, and 5-year overall survival (± SE in these two groups was 41.7% ± 14.2% (95% CI, 21.3% to 81.4% and 58.3% ± 18.6% (95% CI, 31.3% to 100%, respectively. Children younger than 3 years old had 5-year progression-free and overall survival rates (± SE of 47.6% ± 12.1% (95% CI, 28.9% to 78.4% and 45.6% ± 11.7% (95% CI, 27.6% to 75.5%, respectively. Time to relapse ranged from 4 to 132 months. Most patients who experienced relapse died within 1 year. Febrile neutropenia, hearing loss, and endocrinopathy were the most common treatment-related complications. Conclusion: The survival rate of childhood MB in Malaysia is inferior to that usually reported in the literature. We postulate that the following factors contribute to this difference: lack of a multidisciplinary neuro-oncology team, limited health care facilities, inconsistent risk assessment, insufficient data in the National Cancer

  20. Carboniferous paleogeographic, phytogeographic, and paleoclimatic reconstructions

    Science.gov (United States)

    Rowley, D.B.; Raymond, A.; Parrish, Judith T.; Lottes, A.L.; Scotese, C.R.; Ziegler, A.M.

    1985-01-01

    Two revised paleogeographic reconstructions of the Visean and Westphalian C-D stages are presented based on recent paleomagnetic, phytogeographic, stratigraphic, and tectonic data. These data change the positions of some continental blocks, and allow the definition of several new ones. The most important modifications that have been incorporated in these reconstructions are: (1) a proposed isthmus linking North America and Siberia across the Bering Strait; and (2) the separation of China and Southeast Asia in six major blocks, including South China, North China, Shan Thai-Malaya, Indochina, Qangtang, and Tarim blocks. Evidence is presented that suggests that at least the South China, Shan Thai-Malaya, and Qangtang blocks were derived from the northern margin of Gondwana. Multivariate statistical analysis of phytogeographic data from the middle and late Paleozoic allow definition of a number of different phytogeographic units for four time intervals: (1) the Early Devonian, (2) Tournaisian-early Visean, (3) Visean, and (4) late Visean-early Namurian A. Pre-late Visean-early Namurian A floral assemblages from South China show affinities with northern Gondwana floras suggesting a southerly position and provides additional support for our reconstruction of South China against the northern margin of Gondwana. There is a marked decrease in the diversity of phytogeographic units in the Namurian and younger Carboniferous. This correlates closely with the time of assembly of most of Pangaea. The general pattern of Carboniferous phytogeographic units corresponds well with global distribution of continents shown on our paleogeographic reconstructions. In addition, we have constructed paleoclimatic maps for the two Carboniferous time intervals. These maps stress the distribution of rainfall, as this should be strongly correlated with the floras. There is marked change in the rainfall patterns between the Visean and Westphalian C-D. This change corresponds with the closing of

  1. Users’ perspectives on Implanon in Malaysia, a multicultural Asian country

    Directory of Open Access Journals (Sweden)

    Asmah Mastor

    2011-02-01

    Full Text Available Asmah Mastor, Si Lay Khaing, Siti Zawiah Omar Department of Obstetrics and Gynaecology, University of Malaya, Kuala Lumpur, MalaysiaBackground: The primary objective of this study was to evaluate Malaysian women’s ¬perception, acceptance, and views on Implanon® as a contraceptive method. We also aimed to identify women who favor Implanon, their vaginal bleeding patterns, nonmenstrual adverse events, reasons for discontinuation, and effect of Implanon on breastfeeding.Study design: This study followed up 140 women after insertion of Implanon at the University of Malaya Medical Centre by examination of their medical records and telephone interviews. User profile, discontinuation rate, reasons for choice of Implanon, discontinuation, menstrual and nonmenstrual side effects, and satisfaction rate were assessed.Results: The average age of users was 34.7 years, and 94.2% were para 2 and above. The ethnic distribution of the women reflected that of the general Malaysian population. The majority had at least secondary education (94.2%, with 41.2% having a higher degree. All of the users reported that they chose Implanon because it does not need compliance, and 72.1% felt that Implanon was cost-effective in the long term. Most users (70% reported irregular menses and this was the main reason given for discontinuation. The vast majority reported an overall decrease in menstrual blood loss. Almost half (46% suffered prolonged bleeding/spotting, and infrequent bleeding was experienced by 71 users (50.7%. Half of the women did not experience any nonmenstrual adverse events. The commonest complaint was weight gain, with the next most common complaints being hair loss, acne, headache, nausea, mood swings, and reduced libido. Most of the nursing mothers denied a reduction in breast milk. There was a high mean satisfaction score with Implanon.Conclusion: Implanon is well accepted by Malaysian women despite a high incidence of irregular bleeding which was

  2. Outcome of invasive lobular carcinoma of breast in Malaysia

    Directory of Open Access Journals (Sweden)

    Kamudin Nur Allaiyna Ferdaus

    2017-12-01

    Full Text Available Background: Breast cancer is the commonest cancer and 2nd most common cause of cancer death among women worldwide. Histologically breast cancer can be divided into Invasive Lobular Carcinoma (ILC, Invasive Ductal Carcinoma (IDC and others. ILC has its own unique patient’s demographic, histological appearance, imaging characteristics and clinical outcome. Previous published study has shown that ILC has better overall survival compared to IDC. Sadly, despite being so common, there is still lack of study comparing ILC and IDC in Malaysia setting. Methods: 5225 of patients diagnosed with ILC and IDC were managed in University Malaya Medical Center within 1993 to 2013 has been included in this study. Chi square test were performed to determine the demographic and clinical factors associated with ILC and IDC. Kaplen-Meier method was used to obtain overall survival of these patients. Through a Cox regression analysis, mortality in patients diagnosed with ILC and IDC were identified, by adjusting the possible confounding factors. Results: ILC is more common in elderly compared to younger patients. There is no association between ethnicity and types of invasive carcinoma. Patients with ILC were more likely to have lymph nodes involvement (p = 0.001, estrogen receptor positive (p = 0.001, absent of lymphovascular invasion (p = 0.028, mastectomy (p = 0.022 and hormonal therapy (p = 0.002 compared to IDC and it is statistically significant. Nevertheless, survival was not significantly different between ILC and IDC; 5-year OS; 77.4% (95% CI 77.34 to 77.46 and 71.3% (95% CI 71.29 to 71.30, respectively; the 10 year OS; 52.2% (95% CI 52.13 to 52.27 and 49.7% (95% CI 49.68 to 49.72, respectively. The adjusted hazard ratio comparing ILC and IDC using Cox regression was 1.21 (0.85 to 1.72 showing there is no significant difference between patients presented with ILC and IDC in terms of survival. Conclusion: Based on Malaysian data gathered from University

  3. Spatial‑temporal variability of water balance components in the North area of the Zailiisky Alatau Range

    Directory of Open Access Journals (Sweden)

    V. G. Konovalov

    2016-01-01

    Full Text Available Analysis of changes in WB components (precipitation, evaporation, glacier runoff, dynamical water resources on the Northern slope of the Zailiisky Alatau was performed for the 1946–2005 time divided into two periods: 1946–1975 and 1976–2005. The territory under investigation included basins of the following rivers: Bolshaya Almatinka, Malaya Almatinka, Talgar, Turgen, Issyk, Chemolgan, Kaskelen, Kargalinka, Prohodnaya, and Uzunkargaly. Their total area down to the closing gauge points amounts to 2644 km2. Summarized glacier areas in these basins and annual runoff were equal, respectively, to: 306.6 km2 and 39.05 km3in 1946–1975, and 253.0 km2 and 38.35 km3 in 1975–2005. In 1946–2005, typical features of regional glaciation dynamics were increasing area of the moraine cover on glaciers and reducing area of bare ice that results in decreasing of the glacial runoff volume, all other factors being the same. The method to calculate the WB components consists of the following constituents: model of seasonal runoff from melted snow and ice in the areas of accumulation and ablation of glaciers; complex of formulas to calculate precipitation, air temperature and humidity, intensity of ice melting under the moraine, bare ice and evaporation within the height intervals corresponding to the main types of surfaces on the glaciers. On the basis of our method, we could reconstruct for the 1876–2015 period long‑term series of data on a runoff, separately annual values and sums for the vegetation periods. They can be used for regional scientific and applied analyses of the river stream discharges. The data on runoff in the Malaya Almatinka River basin and observational data on the meteorological station Almaty (Hydrometeorological Observatory had been quantitatively substantiated as the representative information for modeling and calculation of water resources on the Northern slope of the Zailiisky Alatau Range.

  4. Barriers and facilitators to self-monitoring of blood glucose in people with type 2 diabetes using insulin: a qualitative study

    Directory of Open Access Journals (Sweden)

    Ong WM

    2014-02-01

    Full Text Available Woon May Ong,1 Siew Siang Chua,1 Chirk Jenn Ng2 1Department of Pharmacy, 2University of Malaya Primary Care Research Group (UMPCRG, Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Background: Self-monitoring of blood glucose (SMBG helps to improve glycemic control and empowerment of people with diabetes. It is particularly useful for people with diabetes who are using insulin as it facilitates insulin titration and detection of hypoglycemia. Despite this, the uptake of SMBG remains low in many countries, including Malaysia. Purpose: This study aimed to explore the barriers and facilitators to SMBG, in people with type 2 diabetes using insulin. Patients and methods: Qualitative methodology was employed to explore participants’ experience with SMBG. Semistructured, individual in-depth interviews were conducted on people with type 2 diabetes using insulin who had practiced SMBG, in the primary care clinic of a teaching hospital in Malaysia. Participants were purposively sampled from different age groups, ethnicity, education level, and level of glycemic control (as reflected by the glycated hemoglobin [HbA1c], to achieve maximum variation in sampling. All interviews were conducted using a topic guide and were audio-recorded, transcribed verbatim, checked, and analyzed using a thematic approach. Results: A total of 15 participants were interviewed, and thematic saturation was reached. The factors that influenced SMBG were mainly related to cost, participants' emotion, and the SMBG process. The barriers identified included: frustration related to high blood glucose reading; perception that SMBG was only for insulin titration; stigma; fear of needles and pain; cost of test strips and needles; inconvenience; unconducive workplace; and lack of motivation, knowledge, and self-efficacy. The facilitators were: experiencing hypoglycemic symptoms; desire to see the effects of dietary changes; desire to

  5. A comparison of smoking behaviour characteristics between Caucasian smokers in the United Kingdom and Malay smokers in Malaysia.

    Science.gov (United States)

    Robson, Noorzurani; Bond, Alyson; Wolff, Kim

    2013-01-01

    There is evidence that smoking behaviour differs by ethnicity. This study aims to compare smoking behaviour characteristics between Caucasian and Malay smokers. A cross sectional survey, involving 175 smokers attending smoking cessation clinics at the Institute of Psychiatry, London, United Kingdom and University Malaya, Kuala Lumpur, Malaysia between May 2005 and February 2007. Data on demographics, smoking history, nicotine dependence and smoking behaviour were collected. All participants were males, mean age 30.7 ± 10.3 years. Caucasians initiated smoking significantly earlier (mean age 14.8 ± 2.8 years) (p = 0.001) and smoked regularly significantly earlier (mean age 17.3 ± 3.5) (p = 0.003) than Malays (mean starting age 16.9 ± 4.4 years and mean age regular use 19.5 ± 4.5 years), respectively. Caucasians smoked less for social integration than Malays (p = 0.03) but smoked more for regulation of negative affect than Malays (p = 0.008) and smoked more for hedonism than Malays (p < 0.001). Malays smoke as a means of socially integrating. This has important public health implications. Social reasons and the social environment play a role in smoking uptake, smoking maintenance and smoking cessation and this should be borne in mind for strategies planning to promote smoking cessation. Copyright © 2013 Elsevier Inc. All rights reserved.

  6. Validation of the Malay version of the Amsterdam Preoperative Anxiety and Information Scale (APAIS).

    Science.gov (United States)

    Mohd Fahmi, Z; Lai, L L; Loh, P S

    2015-08-01

    Preoperative anxiety is a significant problem worldwide that may affect patients' surgical outcome. By using a simple and reliable tool such as the Amsterdam Preoperative Anxiety and Information Scale (APAIS), anaesthesiologists would be able to assess preoperative anxiety adequately and accurately. The purpose of this study was to develop and validate the Malay version of APAIS (Malay-APAIS), and assess the factors associated with higher anxiety scores. The authors performed forward and backward translation of APAIS into Malay and then tested on 200 patients in the anaesthetic clinic of University Malaya Medical Centre. Psychometric analysis was performed with factor analysis, internal consistency and correlation with Spielberger's State-Trait Anxiety Inventory (STAI-state). A good correlation was shown with STAI-state (r = 0.59). Anxiety and need for information both emerged with high internal consistency (Cronbach's alpha 0.93 and 0.90 respectively). Female gender, surgery with a higher risk and need for information were found to be associated with higher anxiety scores. On the other hand, previous experience with surgery had lower need for information. The Malay-APAIS is a valid and reliable tool for the assessment of patients' preoperative anxiety and their need for information. By understanding and measuring patient's concerns objectively, the perioperative management will improve to a much higher standard of care.

  7. Vertical distribution of Aedes mosquitoes in multiple storey buildings in Selangor and Kuala Lumpur, Malaysia.

    Science.gov (United States)

    Lau, K W; Chen, C D; Lee, H L; Izzul, A A; Asri-Isa, M; Zulfadli, M; Sofian-Azirun, M

    2013-03-01

    The aim of the present study was to determine the vertical distribution and abundance of Aedes mosquitoes in multiple storey buildings in Selangor and Kuala Lumpur, Malaysia. Ovitrap surveillance was conducted for 4 continuous weeks in multiple storey buildings in 4 residential areas located in Selangor [Kg. Baiduri (KB)] and Kuala Lumpur [Student Hostel of University of Malaya (UM), Kg. Kerinchi (KK) and Hang Tuah (HT)]. The results implied that Aedes mosquitoes could be found from ground floor to highest floor of multiple storey buildings and data from different elevation did not show significant difference. Ovitrap index for UM, KB, HT and KK ranged from 0 - 29.17%, 0 - 55.56%, 8.33 - 83.33% and 0 - 91.17% respectively. Aedes aegypti and Aedes albopictus were found breeding in HT, KK and KB; while only Ae. albopictus was obtained from UM. The results indicate that the invasion of Aedes mosquitoes in high-rise apartments could facilitate the transmission of dengue virus and new approaches to vector control in this type of residential area should be developed.

  8. The UK-SEA-ME Psychosocial-Cultural Cancer Research Network: setting the stage for applied qualitative research on cancer health behaviour in southeast Asia and the Middle East.

    Science.gov (United States)

    Lim, Jennifer N W

    2011-01-01

    Psychosocial and cultural factors influencing cancer health behaviour have not been systematically investigated outside the western culture, and qualitative research is the best approach for this type of social research. The research methods employed to study health problems in Asia predominantly are quantitative techniques. The set up of the first psychosocial cancer research network in Asia marks the beginning of a collaboration to promote and spearhead applied qualitative healthcare research in cancer in the UK, Southeast Asia and the Middle East. This paper sets out the rationale, objectives and mission for the UK-SEA-ME Psychosocial-Cultural Cancer Research Network. The UK-SEA-ME network is made up of collaborators from the University of Leeds (UK), the University of Malaya (Malaysia), the National University of Singapore (Singapore) and the University of United Arab Emirates (UAE). The network promotes applied qualitative research to investigate the psychosocial and cultural factors influencing delayed and late presentation and diagnosis for cancer (breast cancer) in partner countries, as well as advocating the use of the mixed-methods research approach. The network also offers knowledge transfer for capacity building within network universities. The mission of the network is to improve public awareness about the importance of early management and prevention of cancer through research in Asia.

  9. PERSONALITY TRAITS AND STRESS LEVELS AMONG SENIOR DENTAL STUDENTS: EVIDENCE FROM MALAYSIA AND SINGAPORE.

    Science.gov (United States)

    Yusof, Zamros Y M; Hassan, Wan Nurazreena Wan; Razak, Ishak A; Hashim, Siti Marini N; Tahir, Mohd Khairul A M; Keng, Siong Beng

    2016-11-01

    This study aimed to evaluate the association between dental students’ personality traits and stress levels in relation to dental education programs among senior dental students in University Malaya (UM) in Malaysia and National University of Singapore (NUS). A cross-sectional survey using a self-administered questionnaire was conducted on UM and NUS senior dental students. The questionnaire comprised items on demographic background, the Big Five Inventory Personality Traits (BFIPT) test and a modified Dental Environment Stress (DES) scale. Rasch analysis was used to convert raw data to interval scores. Analyses were done by t-test, Pearson correlation, and Hierarchical regression statistics. The response rate was 100% (UM=132, NUS=76). Personality trait Agreeableness (mean=0.30) was significantly more prevalent among UM than NUS students (mean=0.15, p=0.016). In NUS, Neuroticism (mean=0.36) was significantly more prevalent than in UM (mean=0.14, p=0.002). The DES mean score was higher among NUS (mean=0.23) than UM students (mean=0.07). In UM, Neuroticism was significantly correlated with stress levels (r=0.338, ppersonality traits. The correlation was strongest for personality trait Neuroticism in both schools. Hierarchical regression analysis showed that gender and Neuroticism were significant predictors for students’ stress levels (ppersonality trait were significant predictors for stress levels among selected groups of dental students in Southeast Asia. Information on students’ personality may be useful in new students’ intake, stress management counseling and future program reviews.

  10. The Banyan tree: overseas migrants from South Asia.

    Science.gov (United States)

    Tinker, H

    1979-10-01

    The number of Indian emigrants throughout the years has made little or no population difference to the country. With the population of India, Pakistan, and Bangladesh totalling about 700 million in the mid 1970s, emigration is almost irrelevant. In 3 small nations, Mauritius, Fiji, and Guyana, Indians form the majority of the population. Present demographic trends point to the same majority in Trinidad. Indians also are an important group in Malaya, Singapore, and Ceylon, where they are more than 10% of the overall population. In other countries Indians form a small, minority population without political power. Almost all the overseas communities preserved the essential of the Hindu, Muslim, or Sikh religions which they took with them. In the Caribbean the Indian, or East Indian, has discarded his mother tongue after 3 or more generations in isolation. In South Africa only very old emigrants still speak their native tongue. Indian communities abroad often separate into Hindu and Muslim communities. British society uses the term "multi-racial" to describe the pluralistic cultures in its colonies, but British culture is not multiracial. The term has meaning only when applied to an urban area such as Singapore. In Singapore a multilingual policy is applied in order to make the multiracial ideal a reality.

  11. Testing students' e-learning via Facebook through Bayesian structural equation modeling.

    Science.gov (United States)

    Salarzadeh Jenatabadi, Hashem; Moghavvemi, Sedigheh; Wan Mohamed Radzi, Che Wan Jasimah Bt; Babashamsi, Parastoo; Arashi, Mohammad

    2017-01-01

    Learning is an intentional activity, with several factors affecting students' intention to use new learning technology. Researchers have investigated technology acceptance in different contexts by developing various theories/models and testing them by a number of means. Although most theories/models developed have been examined through regression or structural equation modeling, Bayesian analysis offers more accurate data analysis results. To address this gap, the unified theory of acceptance and technology use in the context of e-learning via Facebook are re-examined in this study using Bayesian analysis. The data (S1 Data) were collected from 170 students enrolled in a business statistics course at University of Malaya, Malaysia, and tested with the maximum likelihood and Bayesian approaches. The difference between the two methods' results indicates that performance expectancy and hedonic motivation are the strongest factors influencing the intention to use e-learning via Facebook. The Bayesian estimation model exhibited better data fit than the maximum likelihood estimator model. The results of the Bayesian and maximum likelihood estimator approaches are compared and the reasons for the result discrepancy are deliberated.

  12. Measurement Technique in Radio Frequency Interference (RFI) Study for Radio Astronomy Purposes

    International Nuclear Information System (INIS)

    Roslan Umar; Roslan Umar; Nor Hazmin Sabri; Zainol Abidin Ibrahim; Zamri Zainal Abidin; Asyaari Muhamad

    2015-01-01

    In this paper, we will review our method in making measurements of radio frequency interference (RFI) in order to investigate the sereneness of interference in selected radio interference in Malaysia and Thailand. The selected site are University of Malaya (UM), Universiti Pendidikan Sultan Idris (UPSI), Ubon (UB) and Chiang Mai (CM). The major RFI affecting radio astronomical windows below 1 GHz are electronic equipment system specifically radio navigation between 73.1 MHz and 75.2 MHz, radio broadcasting (151 MHz, 151.8 MHz and 152 MHz), aeronautical navigation (245.5 MHz, 248.7 MHz and 249 MHz and also fixed mobile at 605 MHz, 608.3 MHz, 612.2 MHz, 613.3 MHz. It is obviously showed that all sites within this region are free from interference between 320MHz and 330 MHz and is the best specific region to be considered for solar burst monitoring. We also investigate the effect of RFI on discovery of solar burst. (author)

  13. Lung cancer in patients younger than 40 years in a multiracial Asian country.

    Science.gov (United States)

    Liam, C K; Lim, K H; Wong, C M

    2000-12-01

    This study aimed to determine whether the clinicopathological features of lung cancer in patients younger than 40 years differ from that of older patients in an Asian country. We undertook a review of the clinicopathological data of all patients with confirmed primary lung cancer at the Department of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia, from October 1991 to September 1999. Of the 580 patients with lung cancer, 36 (6.2%; 23 males, 13 females) were 21-39 years old at diagnosis. The percentage of people who had never smoked was higher among the younger patients (58.3% vs 19.1%, P < 0.001). Although adenocarcinoma was the most common cell type in both groups, its incidence was higher in the younger patients (24/36 (66.7%) vs 228/544 (41.9%), P = 0.007). The mean World Health Organization performance status at presentation was worse in the younger patients (2.4 vs 2, P = 0.007). In the case of non-small cell lung cancer, all the younger patients presented with either stage IIIb or metastatic disease compared to 77.2% of the older patients (P < 0.001). Younger lung cancer patients were more likely than older patients to have never smoked, to have adenocarcinoma, and to present with poorer performance status and with more advanced-stage non-small cell lung cancer.

  14. Hospitalization of childhood rotavirus infection from Kuala Lumpur, Malaysia.

    Science.gov (United States)

    Lee, W S; Veerasingam, P D; Goh, A Y T; Chua, K B

    2003-01-01

    To determine the epidemiology of rotavirus gastroenteritis in children admitted to an urban hospital in a developing country from South-East Asia. Retrospective review of cases of acute gastroenteritis admitted to the children's ward of the University of Malaya Medical Centre, Kuala Lumpur, Malaysia, between 1996 and 1999. During the study period, 333 cases (24%) of 1362 stool samples, obtained from children admitted with acute diarrhoea, were positive for rotavirus. Acute gastroenteritis constituted 8.2%, and rotavirus infection 1.6% of all the paediatric admissions each year. Of the 271 cases analysed, 72% of the affected population were less than 2 years of age. Peak incidence of admissions was between January to March, and September to October. Dehydration was common (92%) but electrolyte disturbances, lactose intolerance (5.2%), prolonged diarrhoea (2.6%) and cow's milk protein intolerance was uncommon. No deaths were recorded. Rotavirus infection was a common cause of childhood diarrhoea that required hospital admission in an urban setting in Malaysia.

  15. A retrospective review of methotrexate-induced hepatotoxicity among patients with psoriasis in a tertiary dermatology center in Malaysia.

    Science.gov (United States)

    Ng, Lim Chui; Lee, Yin Yin; Lee, Chew Kek; Wong, Su-Ming

    2013-01-01

    Methotrexate (MTX) is a common and efficacious systemic agent used for the treatment of moderate to severe psoriasis. Nevertheless, its use is associated with the risk of hepatotoxicity. This study was performed to study the association of MTX dose with regards to hepatotoxicity as evidenced by deranged transaminases. This was a retrospective review of patients with psoriasis on MTX from 2000 to 2009 at the outpatient dermatology clinic, University Malaya Medical Centre (UMMC). We analyzed patients' demography, serial laboratory investigations, liver ultrasounds, and liver biopsies of patients on MTX. Sixty-six of 710 (9.30%) patients with psoriasis were prescribed MTX throughout the 10-year period. Among them 57.6% developed deranged transaminases, with six requiring MTX withdrawal due to hepatotoxicity. The mean cumulative dose of MTX at the detection of liver enzyme derangement was 552.3 ± 596.1 mg. A high proportion of patients on MTX had deranged transaminases. However, the number of serious events was low. We concluded from this study that the use of MTX is relatively safe in patients with moderate to severe psoriasis. © 2013 The International Society of Dermatology.

  16. Building a DNA barcode reference library for the true butterflies (Lepidoptera) of Peninsula Malaysia: what about the subspecies?

    Science.gov (United States)

    Wilson, John-James; Sing, Kong-Wah; Sofian-Azirun, Mohd

    2013-01-01

    The objective of this study was to build a DNA barcode reference library for the true butterflies of Peninsula Malaysia and assess the value of attaching subspecies names to DNA barcode records. A new DNA barcode library was constructed with butterflies from the Museum of Zoology, University of Malaya collection. The library was analysed in conjunction with publicly available DNA barcodes from other Asia-Pacific localities to test the ability of the DNA barcodes to discriminate species and subspecies. Analyses confirmed the capacity of the new DNA barcode reference library to distinguish the vast majority of species (92%) and revealed that most subspecies possessed unique DNA barcodes (84%). In some cases conspecific subspecies exhibited genetic distances between their DNA barcodes that are typically seen between species, and these were often taxa that have previously been regarded as full species. Subspecies designations as shorthand for geographically and morphologically differentiated groups provide a useful heuristic for assessing how such groups correlate with clustering patterns of DNA barcodes, especially as the number of DNA barcodes per species in reference libraries increases. Our study demonstrates the value in attaching subspecies names to DNA barcode records as they can reveal a history of taxonomic concepts and expose important units of biodiversity.

  17. Rotavirus and other enteropathogens in childhood acute diarrhoea: a study of two centres in Malaysia.

    Science.gov (United States)

    Lee, Way S; Rajasekaran, Ganeswrie; Pee, Susan; Karunakaran, Rina; Hassan, Hamimah H; Puthucheary, Savithri D

    2006-09-01

    To study the role of rotavirus in children hospitalised for acute gastroenteritis (AGE) in two urban hospitals in Malaysia. A 12-month prospective study (January to December 2002), in children younger than 14 years with AGE hospitalised to the paediatric units of University of Malaya Medical Centre (UMMC), Kuala Lumpur; and Hospital Sultanah Aminah (HSA), Johor Bahru, Malaysia was conducted. In 2002, 399 and 1307 children with AGE were admitted to UMMC and HSA, respectively. Two hundred and eighty-eight (72%) stool samples from UMMC and 901 (69%) samples from HSA were analysed. Rotavirus was the most common aetiological agent identified in both centres (average 32%; UMMC 35%, HSA 30%, P = 0.94). The peak age group for rotavirus-related hospitalisation was 24-35 months for UMMC and 12-23 months for HSA. Nine percent of patients hospitalised for rotavirus infection in UMMC and 22% of patients in HSA were older than 5 years of age. An outbreak of rotavirus infection within the communities served by both centres resulting in an increase in hospital admissions of rotavirus gastroenteritis was observed in both units from January to March 2002. The peak age group for rotavirus-related hospital admission in this study was much older, between 12 to 35 months. It is uncertain whether this was related to the outbreak of rotavirus gastroenteritis observed within two urban areas from January to March 2002 causing re-infection with rotavirus in older children.

  18. Racial variations in booking haemoglobin of primigravidae in Malaysia: a prospective study.

    Science.gov (United States)

    Tan, Albert Chao Chiet; Leong, Eugene Weng Kong; Chua, Ai Chen; Moy, Foong Ming

    2013-05-01

    Variations in racial haemoglobin had been previously described in multiple studies locally and abroad. This study was conducted to quantify the differences in haemoglobin of booking primigravidae amongst the three major races in Malaysia at the antenatal clinic of University Malaya Medical Centre, Kuala Lumpur. One year prospective study of booking full blood count sample of primigravidae taken in one centre was conducted. Multiple comparative analyses of the booking haemoglobin were performed using the One-way ANOVA comparative mean test in each trimester. 622 primigravidae without any known history of haematological disorders were recruited into the study. The mean haemoglobin for the Indian race was the lowest compared to the two other races in the second and the third trimesters, and it was found to be statistically significant lower (p- value 0.001) than the Malay race in the second trimester. It was also found that the Indian race had a significantly higher incidence of moderate to severe anaemia (p- value: 0.029). The prevalence of anaemia in our study population is also significantly higher in the Indian population (p- value: 0.01). The findings from this study have established that there is racial preponderance to anaemia in pregnancy. The Indian race is at a higher risk of having anaemia in pregnancy particularly in the second trimester.

  19. Radiological study on newly developed composite corn advance lines in Malaysia

    Science.gov (United States)

    Adekunle Olatunji, Michael; Bemigho Uwatse, Onosohwo; Uddin Khandaker, Mayeen; Amin, Y. M.; Faruq, G.

    2014-12-01

    Owing to population growth, there has been high demand for food across the world, and hence, different agricultural activities such as use of phosphate fertilizers, recycling of organic matters, etc, have been deployed to increase crop yields. In Malaysia, a total of nine composite corn advance lines have been developed at the Institute of Biological Sciences, University of Malaya and are being grown under different conditions with a bid to meet the average daily human need for energy and fiber intake. To this end, the knowledge of radioactivity levels in these corn advance lines are of paramount importance for the estimation of possible radiological hazards due to its consumption. Hence, the radioactivity concentrations of 226Ra, 228Ra and 40K in the corn have been determined using HPGe γ-ray spectrometry. The activity concentrations in the corn ranged from 0.05 to 19.18 Bq kg-1 for 226Ra, from 0.10 to 3.22 Bq kg-1 for 228Ra and from 26.4 to 129 Bq kg-1 for 40K. In order to ascertain the radiological safety of the population regarding maize consumption, the daily intakes of these radionuclides as well as the annual effective dose were estimated. The total effective dose obtained due to the ingestion of radionuclides via maize consumption is 15.39 μSv y-1, which is less than the international recommendations.

  20. Adult anthropometric measures and socio-demographic factors influencing age at menarche of university students in malaysia.

    Science.gov (United States)

    Hossain, Md Golam; Wee, Ai-Sze; Ashaie, Maeirah; Kamarul, T

    2013-09-01

    Early onset of menarche has been shown to be associated with breast cancer and ischaemic heart disease. Studies on age at menarche of the Malaysian population are poorly documented. This study aimed to determine the influence of anthropometric and socio-demographic factors on the age at menarche of university students in Malaysia. Data were obtained in 2010-11 from 961 students between the ages of 18 and 25 years from the University of Malaya using stratified sampling, and multiple regression analysis was applied. Sixty-three per cent of students reached menarche at the age of 12 or 13 years, with the mean and median of age at menarche being 12.45 ± 1.17 and 12.01 years, respectively. Menarcheal age was positively associated with height (pObese and overweight students reached menarche earlier than students who were underweight or of normal weight (p<0.01). The variations in age at menarche among the Malaysian ethnic groups were statistically insignificant. The results suggest that heavier and first-born students from small families are more likely to attain menarche earlier than their counterparts.

  1. A solar vehicle based on sustainable design concept

    Energy Technology Data Exchange (ETDEWEB)

    Taha, Z.; Sah, J.M.; Passarella, R.; Ghazilla, R.A.R.; Ahmad, N.; Jen, Y.H.; Khai, T.T.; Kassim, Z.; Hasanuddin, I.; Yunus, M. [Malaya Univ., Kuala Lumpur (Malaysia). Faculty of Engineering, Centre for Product Design and Manufacture

    2009-07-01

    This paper described a newly constructed solar vehicle that was built specifically for the 2009 World Solar Challenge (WSC) using off-the-shelf parts. Researchers at the Centre for Product Design and Manufacture at the University of Malaya designed and built the solar car which uses solar energy to charge its batteries. Although the total investment for this sustainable product concept is small compared to other solar vehicles, the car's performance has met expectations. Most of the electrical and mechanical parts can be recycled and reused after the WSC event. The photovoltaic (PV) and maximum power point trackers (MPPT) can be re-used for home applications. The DC motor and the controller can be attached to a bicycle and the aluminium parts which make-up the main body structure can be recycled. The design will result in nearly zero waste. The study showed that the process of combining mechanical and electrical components is not an easy task, particularly at the design stage because of the specific characteristics and functions of the individual parts. This paper described how readily available, off-the-shelf mechanical and electrical components were integrated for the solar vehicle. The conceptual design and the performance of the prototype were also presented. 11 refs., 5 tabs., 11 figs.

  2. "You still need to give her a token of appreciation": the meaning of the exchange of money in the sexual relationships of out-of-school adolescents in rural southwest Uganda.

    Science.gov (United States)

    Nobelius, Ann-Maree; Kalina, Bessie; Pool, Robert; Whitworth, Jimmy; Chesters, Janice; Power, Robert

    2010-09-01

    This article challenges the pervasive assumption that exchanging gifts and money in adolescent sexual relationships is transactional. Data were derived from a multi-method, qualitative sexual health needs assessment of 31 out-of-school adolescents in rural southwest Uganda. Grounded theory analysis allows contextual meanings of exchange to emerge. Adolescents have developed gendered courting and exchange models that parallel marital relationships in this cultural context. Whereas exchange is considered transactional and immoral in some types of relationships, in adolescent relationships, it is not. Young women are not ashamed of, or stigmatized by, the exchange; they are proud of it. The exchange signifies several things: self-respect and a partner's willingness to wait for the relationships to become sexual and, therefore, that they are valued and respected by their partners. This demonstrates commitment from a partner, whose role is as a provider. To expect no gift or to have sex for pleasure are the hallmarks of the worst kind of woman-a malaya. "Need" is the only acceptable rationale for extramartial sex for any woman in this sexual value system. Interventions promoting longer courting and sustained support for one partner would encourage a delay in debut for young women and encourage greater monogamy in young men.

  3. Factors contributing to hearing impairment in patients with cleft lip/palate in Malaysia: A prospective study of 346 ears.

    Science.gov (United States)

    Cheong, Jack Pein; Soo, Siew Shuin; Manuel, Anura Michelle

    2016-09-01

    To determine the factors contributing towards hearing impairment in patients with cleft lip/palate. A prospective analysis was conducted on 173 patients (346 ears) with cleft lip and palate (CL/P) who presented to the combined cleft clinic at University Malaya Medical Centre (UMMC) over 12 months. The patients' hearing status was determined using otoacoustic emission (OAE), pure tone audiometry (PTA) and auditory brainstem response (ABR). These results were analysed against several parameters, which included age, gender, race, types of cleft pathology, impact and timing of repair surgery. The patients' age ranged from 1-26 years old. They comprised 30% with unilateral cleft lip and palate (UCLP), 28% with bilateral cleft lip and palate (BCLP), 28% with isolated cleft palate (ICP) and 14% with isolated cleft lip (ICL). Majority of the patients (68.2%) had normal otoscopic findings. Out of the 346 ears, 241 ears (70%) ears had passed the hearing tests. There was no significant relationship between patients' gender and ethnicity with their hearing status. The types of cleft pathology significantly influenced the outcome of PTA and ABR screening results (p cleft groups and the outcome of hearing tests. However, hearing improvement occurred when palatal repair was performed at the age of cleft patients had normal hearing (70%). Hearing threshold varied significantly between the different types of cleft pathology. Surgery conferred no significant impact on the hearing outcome unless surgery was performed at the age of <1 year old. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  4. Mosquito Surveys Carried out On Green Island, Orchid Island, and Penghu Island, Taiwan, in 2003

    Directory of Open Access Journals (Sweden)

    Hwa-Jen Teng

    2005-02-01

    Full Text Available Field surveys of mosquitoes were carried out on Green, Orchid, and Penghu Islands in 2003 to ascertain the status of mosquito vectors. Eighteen species of mosquitoes were collected, including three species of Anopheles, four species of Aedes, eight species of Culex, two species of Armigeres, and one species of Malaya. Seventeen previously recorded species were not collected in this study but 11 species collected had not previously been recorded. Ten newly recorded species, An. maculatus, An. takasagoensis, Ae. alcasidi, Ae. lineatopennis, Ae. vexans vexans, Ar. omissus, Cx. vishnui, Cx. halifaxii, Cx. hayashii, and Cx. neomimulus, were collected on Green Island and one previously unrecorded species, Ar. subalbatus, was collected on Orchid Island. Potential vectors An. maculatus and An. sinensis, malaria vectors in Korea and Mainland China, Ae. albopictus, a vector of dengue in Taiwan and West Nile virus in the USA, Cx. vishnui and Cx. tritaeniorhynchus, Japanese encephalitis vectors in Taiwan, Ae. vexans vexans, an eastern equine encephalitis vector in the USA, and Cx. quinquefasciatus, a vector of filariasis in Taiwan and West Nile virus in the USA, were among the mosquito species collected.

  5. Isolation and Characterization of an Atypical Metschnikowia sp. Strain from the Skin Scraping of a Dermatitis Patient.

    Directory of Open Access Journals (Sweden)

    Chee Sian Kuan

    Full Text Available A yeast-like organism was isolated from the skin scraping sample of a stasis dermatitis patient in the Mycology Unit Department of Medical Microbiology, University Malaya Medical Centre (UMMC, Kuala Lumpur, Malaysia. The isolate produced no pigment and was not identifiable using chromogenic agar and API 20C AUX. The fungus was identified as Metschnikowia sp. strain UM 1034, which is close to that of Metschnikowia drosophilae based on ITS- and D1/D2 domain-based phylogenetic analysis. However, the physiology of the strain was not associated to M. drosophilae. This pathogen exhibited low sensitivity to all tested azoles, echinocandins, 5-flucytosine and amphotericin B. This study provided insight into Metschnikowia sp. strain UM 1034 phenotype profiles using a Biolog phenotypic microarray (PM. The isolate utilized 373 nutrients of 760 nutrient sources and could adapt to a broad range of osmotic and pH environments. To our knowledge, this is the first report of the isolation of Metschnikowia non-pulcherrima sp. from skin scraping, revealing this rare yeast species as a potential human pathogen that may be misidentified as Candida sp. using conventional methods. Metschnikowia sp. strain UM 1034 can survive in flexible and diverse environments with a generalist lifestyle.

  6. Prevalence of intestinal parasites among members of the public in Kuala Lumpur, Malaysia.

    Science.gov (United States)

    Jamaiah, I; Rohela, M

    2005-01-01

    A total of 246 stool samples were collected from the public who participated in a Medical Fair held at the University Malaya Medical Center. The stools were examined for intestinal parasites using the formalin-ether concentration technique. The overall infection rate was 6.9% (17 out of 246), with Trichuris trichiura being the most common parasite (4.5%), followed by Ascaris lumbricoides (0.8%), Clonorchis sinensis (0.8%), hookworm (0.4%), and Entamoeba histolytica (0.4%). None of these participants showed any clinical symptoms. The highest infection rate was among the Chinese 7.7% (13 out of 169), followed by the Malays 7.0% (3 out of 43) and Indians 3.3% (1 out of 30). The highest infection rate was in the age group 16-30 years, which was 9% (6 out of 67). The two cases of clonorchiasis were from two Chinese women aged 28 and 66 years. The 28-year-old Chinese woman was born in Malaysia and had never left the country, while the older woman was also born in Malaysia but had visited Hong Kong as a tourist on two occasions. Both enjoyed eating raw fresh water fish with porridge.

  7. Japanese Encephalitis in Malaysia: An Overview and Timeline.

    Science.gov (United States)

    Kumar, Kiven; Arshad, Siti Suri; Selvarajah, Gayathri Thevi; Abu, Jalila; Toung, Ooi Peck; Abba, Yusuf; Yasmin, A R; Bande, Faruku; Sharma, Reuben; Ong, Bee Lee

    2018-05-29

    Japanese encephalitis (JE) is a vector-borne zoonotic disease caused by the Japanese encephalitis virus (JEV). It causes encephalitis in human and horses, and may lead to reproductive failure in sows. The first human encephalitis case in Malaya (now Malaysia) was reported during World War II in a British prison in 1942. Later, encephalitis was observed among race horses in Singapore. In 1951, the first JEV was isolated from the brain of an encephalitis patient. The true storyline of JE exposure among humans and animals has not been documented in Malaysia. In some places such as Sarawak, JEV has been isolated from mosquitoes before an outbreak in 1992. JE is an epidemic in Malaysia except Sarawak. There are four major outbreaks reported in Pulau Langkawi (1974), Penang (1988), Perak and Negeri Sembilan (1998-1999), and Sarawak (1992). JE is considered endemic only in Sarawak. Initially, both adults and children were victims of JE in Malaysia, however, according to the current reports; JE infection is only lethal to children in Malaysia. This paper describes a timeline of JE cases (background of each case) from first detection to current status, vaccination programs against JE, diagnostic methods used in hospitals and factors which may contribute to the transmission of JE among humans and animals in Malaysia. Copyright © 2018. Published by Elsevier B.V.

  8. Pediatric craniomaxillofacial injuries after road traffic crashes: characteristics of injuries and protective equipment use.

    Science.gov (United States)

    Yunus, Siti Salmiah Mohd; Ngeow, Wei Cheong; Ramli, Roszalina

    2015-09-01

    A cross-sectional study to determine the pattern of craniomaxillofacial (CMF) injuries among children involved in road traffic crashes was performed. The association of protective equipment use with the CMF injuries was evaluated. Retrospective records of children treated in the University Malaya Medical Centre, Kuala Lumpur, Malaysia, after road traffic crashes between January 1, 2008 and December 31, 2012 were reviewed, and, after that, telephone interviews were made. Seventy-one children were included in this study. Fifty-two (73.6%) were involved in a motorcycle injury and 19 (23.4%) in a car crash. Their mean age was 6.02 years; SD, 3.46 (range between 0 to 13 years old). More male children were observed (52.1%) compared with females (47.9%). Thirty-nine point four percent of the children sustained CMF injuries, 33.8% body injuries, and 23.9% had both CMF and other body parts injuries. The highest injury severity score was 26, whereas the lowest was 0. Many children did not use protective equipment during traveling, 44.2% of children among motorcycle pillion riders, and 78.9% among car passengers. The association between helmet use and CMF injuries was shown to be statistically significant (P belt. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Radiological study on newly developed composite corn advance lines in Malaysia

    International Nuclear Information System (INIS)

    Olatunji, Michael Adekunle; Uwatse, Onosohwo Bemigho; Khandaker, Mayeen Uddin; Amin, Y M; Faruq, G

    2014-01-01

    Owing to population growth, there has been high demand for food across the world, and hence, different agricultural activities such as use of phosphate fertilizers, recycling of organic matters, etc, have been deployed to increase crop yields. In Malaysia, a total of nine composite corn advance lines have been developed at the Institute of Biological Sciences, University of Malaya and are being grown under different conditions with a bid to meet the average daily human need for energy and fiber intake. To this end, the knowledge of radioactivity levels in these corn advance lines are of paramount importance for the estimation of possible radiological hazards due to its consumption. Hence, the radioactivity concentrations of 226 Ra, 228 Ra and 40 K in the corn have been determined using HPGe γ-ray spectrometry. The activity concentrations in the corn ranged from 0.05 to 19.18 Bq kg −1 for 226 Ra, from 0.10 to 3.22 Bq kg −1 for 228 Ra and from 26.4 to 129 Bq kg −1 for 40 K. In order to ascertain the radiological safety of the population regarding maize consumption, the daily intakes of these radionuclides as well as the annual effective dose were estimated. The total effective dose obtained due to the ingestion of radionuclides via maize consumption is 15.39 μSv y −1 , which is less than the international recommendations. (paper)

  10. Failed magnetic resonance imaging examinations due to claustrophobia

    International Nuclear Information System (INIS)

    Sarji, S.A.; Abdullah, B.J.J.; Kumar, G.; Tan, A.H.; Narayanan, P.

    1998-01-01

    A recognised cause of incomplete or cancelled MRI examinations is anxiety and claustrophobic symptoms in patients undergoing MR scanning. This appears to be a problem in many MRI centres in Western Europe and North America, where it is said to be costly in terms of loss of valuable scan time, and has led to researchers suggesting several anxiety reducing approaches for MRI. To determine the incidence of failed MRI examination among our patients and if there are any associations with a patient's sex, age and education level, we studied claustrophobia that led to premature termination of the MRI examination in the University Malaya Medical Centre (UMMC) in 3324 patients over 28 months. The incidence of failed MRI examinations due to claustrophobia in the UMMC was found to be only 0.54%. There are associations between claustrophobia in MRI with the patients' sex, age and level of education. The majority of those affected were male patients and young patients in the 25-45-year age group. The patients' education level appears to be the strongest association with failed MRI examinations due to claustrophobia, where the majority of the affected were highly educated individuals. Claustrophobia in MRI is more of a problem among the educated individuals or patients from a higher socio-economic group, which may explain the higher incidence in Western European and North American patients. Copyright (1998) Blackwell Science Pty Ltd

  11. Book Reviews

    Directory of Open Access Journals (Sweden)

    Alistair Lamb

    1964-10-01

    Full Text Available - B.V.A. Röling, Paul Shepard, Psycholex. Megwa, New York, 1960. 144 blz. - L. Sluimers, J.F. Cady, Southeast Asia: Its historical development. New York etc., McGraw-Hill Book Company, 1964. XVII, 657, IX blz., foto, krtn. - H.J. de Graaf, Nicholas Tarling, Piracy and politics in the Malay world. A study of British imperialism in nineteenth-century Sout-East Asia. F.W. Cheshire, Melbourne, Canberra, Sydney, 1963. 273 pp., frontispiece, endpaper maps. - W. Brand, N.A. Simoniya, Overseas Chinese in Southeast Asia - A Russian study. Data Paper Number 45, Southeast Asia Program, Department of Far Eastern Studies, Cornell University Press, Ithaca, New York, December 1961, 151 blz. - B.H.M. Vlekke, Alistair Lamb, The China-India border, The origins of the disputed boundaries. Published for the Royal Institute of International Affairs by Oxford University Press, London 1964, XVI + 192 pp. - R.S. Karni, Beda Lim, Malaya, a background bibilography. Journal Malayan Branch, RAS, vol. XXXV, pts. 2 & 3, 1962; V. 199 pp. - L. Sluimers, R.K. Goldsen, Factors related to acceptance of innovation in Bang Chan, Thailand; Analysis of a survey conducted by the Cornell Cross-cultural Methodology Project, May 1955. Cornell Thailand Project Interim Report Series no. 3. Data Paper: No. 25 Southeast Asia Program Department of Far Eastern Studies Cornell University. 3de druk, Ithaca, Cornell University Press, 1963. VIII, 72, X blz., M. Rallis (eds.

  12. From Undang-undang Melaka to federal constitution: the dynamics of multicultural Malaysia.

    Science.gov (United States)

    Nor, Mohd Roslan Mohd; Abdullah, Ahmad Termizi; Ali, Abdul Karim

    2016-01-01

    Malaysia is a multicultural state comprising three main races: Malays, Chinese and Indians. The three main religions are Islam, Buddhism and Hinduism. Other religions such as Sikhism and Christianity are also practised. Muslims are the majority comprising 67 % of the population. This paper is qualitative in nature. It applies historical comparative method in presenting its data. The Undang - undang Melaka (Malacca Laws) was obtained from the monograph available at National Library of Malaysia under the name of Hukum Kanun Melaka. Analysis was done on selected examples from this document. This paper highlights that had there been no introduction to a common law system, Malaysia would have remained with its traditional laws influenced by Islam and its local customs as evident from Undang - undang Melaka (Malacca laws). The Undang - undang Melaka was practised from 1422 to 1444 and the law of the country was developed to accommodate the introduction of civil law during the colonial period. One of the unique aspects of multicultural Malaysia is the fact that it has a parallel legal system: sharia and civil law. This paper examines histo-cultural development of the Islamic law as practised in pre-independent Malaysia, as well as the coexistence between these two laws after the independence of Malaya in 1957. This paper concludes that Islamic law in Malaysia is confined to Muslim family matters, while civil law covers all other matters.

  13. Female labour force participation and fertility.

    Science.gov (United States)

    Concepcion, M B

    1974-01-01

    The levels of labor force participation by women in selected Asian countries were recorded in a series of censuses taken over a period of years. These levels were less influenced than male employment levels by economic conditions and more influenced by cultural traits of the country. Postwar trends seem to have fallen in Korea, risen in Singapore and the Philippines, and remained steady in Japan, Malaya, and Thailand. The limitations of these data are mentioned. In Thailand and West Malaysia greater percentages of women worked in agricultural than non-agricultural employment; in the Philippines, where women did not work so much in agricultural pursuits, their jobs were still in traditional rather than in development industries. In the cities of Bangkok, Manila, and Kuala Lumpur, fertility was lower for working than for non-working women. In rural agricultural areas, the fertility of working women was minimally higher, probably due to economic need of lar ger families. It is concluded that urban life separates the employment and the family roles of working women, leading to lowered fertility; this does not occur in rural areas. The creation of new roles for women alternative or supplementary to marriage and motherhood would result in lowered fertility. In high fertility Asian countries, policies directed toward greater participation of women in non-agricultural work and great er exposure to an urban lifestyle might achieve fertility reductions.

  14. Psychometric Properties of the Malay Version of the Dutch Eating Behaviour Questionnaire (DEBQ) in a Sample of Malaysian Adults Attending a Health Care Facility.

    Science.gov (United States)

    Subramaniam, Kavitha; Low, Wah Yun; Chinna, Karuthan; Chin, Kin Fah; Krishnaswamy, Saroja

    2017-08-01

    This study aims to investigate the psychometric properties of the Malay version of the Dutch Eating Behaviour Questionnaire (DEBQ) among Malaysian adults. The Malay version of the DEBQ instrument was administered to 398 outpatients (269 women and 129 men) at the University of Malaya Medical Centre (UMMC). Confirmatory Factor Analysis (CFA) was conducted to study the construct validity of the instrument. Composite reliability coefficient, Raykov's rho, was used to determine the internal consistency. The proposed three-factor structure for the DEBQ instrument was appropriate, although three items (Items 21, 14 and 27) showed problematic loadings with inappropriate model fit and were removed. The modified version had an appropriate model fit χ 2 /df = 2.129, TLI = 0.908, CFI = 0.918, RMSEA = 0.053 (90%CI = 0.048-0.058), close-fit P -value = 0.136 and satisfactory internal consistency of 0.914 for emotional eating scale, 0.819 for external eating scale and 0.856 for restrained eating scale. The Malay version of the DEBQ is a valid instrument to study eating behaviour traits among Malaysian adults. Further research is warranted to determine if Items 14 and 27 are appropriate for the Malaysian population.

  15. 10th International Seminar on Medical Physics and 1st AMDI International Oncology Symposium

    International Nuclear Information System (INIS)

    2017-01-01

    scientific committee. Reviews were conducted by expert referees to the professional and scientific standards expected of a proceedings journal published by IOP Publishing. Scientific Committee and Reviewers International Naruhiro Matsufuji, National Institute of Radiological Sciences, Japan Tom Richards, University College London NHS, United Kingdom Supriyanto Ardjo Pawiro, University of Indonesia Mahbubunnabi Tamal, University of Dammam, Saudi Arabia Malaysia Ahmad Nazlim Yusoff, Universiti Kebangsaan Malaysia Ahmad Taufek Abdul Rahman, Universiti Teknologi MARA Ashrani Aizzuddin Abd Rahni, Universiti Kebangsaan Malaysia Hafiz M Zin, Universiti Sains Malaysia Jeannie Hsiu Ding Wong, University of Malaya M Iqbal Saripan, Universiti Putra Malaysia Mohd Zahri Abd Aziz, Universiti Sains Malaysia Ng Kwan Hoong, University of Malaya Noramaliza Mohd Noor, Universiti Putra Malaysia Rafidah Zainon, Universiti Sains Malaysia Shazril Imran Shaukat, Universiti Sains Malaysia Suhairul Hashim, Universiti Teknologi Malaysia Ung Ngie Min, University of Malaya Wan Nordiana Wan Abd Rahman, Universiti Sains Malaysia Yeong Chai Hong, Universiti Malaya Many thanks to all invited speakers, oral presenters and poster presenters for their participation and to the Organising Committee members for all their hard work in making the conference happen. Thanks to all authors who submitted the extended write-up of the work presented at the conference to be included in the volume. The Scientific Committee members and reviewers are also thanked for reviewing the submitted manuscripts and improve the scientific quality of this proceedings. Finally, thanks to all who attended the conference and the sponsors for their financial support. Editor, Proceedings of ISMP and IOS 2016 Hafiz M Zin Universiti Sains Malaysia Host Organisation Advanced Medical and Dental Institute (AMDI) of Universiti Sains Malaysia or IPPT (Malay acronym of the Institute) was established with the vision of developing state

  16. ACCOUNTING PARADIGM OF LIVED EXPERIENCES IN ACTION RESEARCH: THE CASE OF MALAYSIAN PLANTATION WORKERS

    Directory of Open Access Journals (Sweden)

    S. Susela DEVI

    2014-11-01

    Full Text Available This paper introduces action research as a possible new method to reduce the distance between idealism and accounting practice, thus contributing to the accounting literature. The source of this paper is an on-going large research project. The project has three objectives. Firstly, to provide evidence of the utilisation of accounting methods in the Malaya plantation industry from its earliest beginnings through to the introduction of accounting tools such as budgets, leading to the creation of a social and economic underclass in Malaysia. Secondly, to examine the extent to which accounting information provided in the Annual Reports of Malaysian plantation companies is used in determining the wages of plantation workers on the grounds that workers in the plantation industry have been and still are, among the most poorly paid in Malaysia, and perhaps the world. Interestingly, the wages of plantation workers are determined through a negotiation process between the National Union of Plantation Workers and the Malaysian Agricultural Producers Association. This paper draws from this research project and explicates the utilisation of the Action Research methodology in reporting the “lived experiences” of those affected by Management Accounting budgets and demonstrating how the parties to wage negotiation, the employers, union and employees, can better derive value from accounting information provided within the annual reports of Malaysian plantation companies.

  17. RESEARCH UNIVERSITIES IN MALAYSIA: WHAT BEHOLDS?

    Directory of Open Access Journals (Sweden)

    Nooraini Mohamad Sheriff

    2017-12-01

    Full Text Available The National Higher Education Strategic Plan Beyond 2020 aims at further strengthening Malaysian research universities and envisions that two Malaysian universities will be among the Top 100 world universities. To date there are 5 research universities in Malaysia, namely University of Malaya (UM, Universiti Kebangsaan Malaysia (UKM, Universiti Sains Malaysia (USM, Universiti Putra Malaysia (UPM and Universiti Teknologi Malaysia (UTM being the latest addition. These research universities are required to focus primarily on research and innovation activities, driven by highly competent academics and competitive student admissions. Research universities too are expected to explore their intellectual capacity and become models of Malaysian universities in conducting research activities aimed at knowledge advancement. Apart from this research universities are entrusted to generate their own income and establish holding companies responsible for conducting business ventures through the commercialization of their research products. Quality and quantity of researchers, research and postgraduates are also expected to increase in these research driven institutions. This calls for a visionary university leadership and the application of a new image and organizational principles. Education, training and employment policies too have to be reviewed, to ensure staff have the skills necessary for the development of research activities.

  18. Testing students' e-learning via Facebook through Bayesian structural equation modeling.

    Directory of Open Access Journals (Sweden)

    Hashem Salarzadeh Jenatabadi

    Full Text Available Learning is an intentional activity, with several factors affecting students' intention to use new learning technology. Researchers have investigated technology acceptance in different contexts by developing various theories/models and testing them by a number of means. Although most theories/models developed have been examined through regression or structural equation modeling, Bayesian analysis offers more accurate data analysis results. To address this gap, the unified theory of acceptance and technology use in the context of e-learning via Facebook are re-examined in this study using Bayesian analysis. The data (S1 Data were collected from 170 students enrolled in a business statistics course at University of Malaya, Malaysia, and tested with the maximum likelihood and Bayesian approaches. The difference between the two methods' results indicates that performance expectancy and hedonic motivation are the strongest factors influencing the intention to use e-learning via Facebook. The Bayesian estimation model exhibited better data fit than the maximum likelihood estimator model. The results of the Bayesian and maximum likelihood estimator approaches are compared and the reasons for the result discrepancy are deliberated.

  19. Thinking about thinking: changes in first-year medical students’ metacognition and its relation to performance

    Directory of Open Access Journals (Sweden)

    Wei Han Hong

    2015-08-01

    Full Text Available Background: Studies have shown the importance of metacognition in medical education. Metacognitive skills consist of two dimensions: knowledge of metacognition and regulation of metacognition. Aim: This study hypothesizes that the knowledge and regulation of metacognition is significantly different at the beginning and end of the academic year, and a correlation exists between the two dimensions of metacognitive skills with academic performance. Methods: The Metacognitive Skills Inventory comprising 52 Likert-scale items was administered to 159 first-year medical students at the University of Malaya. Students’ year-end results were used to measure their academic performance. Results: A paired sample t-test indicated no significant difference for knowledge of metacognition at the beginning and end of the academic year. A paired sample t-test revealed significant difference for regulation of metacognition at the beginning and end of the academic year. A very strong correlation was found between the two dimensions of metacognition. The correlation between knowledge and regulation of metacognition with students’ academic result was moderate. Conclusions: The improvement in students’ metacognitive regulation and the moderate correlation between knowledge and regulation of metacognition with academic performance at the end of the academic year indicate the probable positive influence of the teaching and learning activities in the medical program.

  20. Melioidosis in acute cholangitis of diabetic patient: a forgotten diagnosis

    Directory of Open Access Journals (Sweden)

    Mohamad N

    2012-08-01

    Full Text Available Nasir Mohamad,1 Suresh Ponnusamy,2 Sunita Devi,3 Rishya Manikam,4 Ilya Irinaz Idrus,1 Nor Hidayah Abu Bakar51Department of Emergency Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia; 2AIMST University, Bedong, Malaysia; 3Hospital Sultan Abdul Halim, Sungai Petani, Malaysia; 4University Malaya Medical Centre, Kuala Lumpur, Malaysia; 5Department of Pathology, Hospital Raja Perempuan Zainab II, Kota Bharu, MalaysiaAbstract: Melioidosis presents with a wide range of clinical presentations, which include severe community-acquired pneumonia, septicemia, central nervous system infection, and less severe soft tissue infection. Hence, its diagnosis depends heavily on the clinical microbiology laboratory for culture. In this case report, we describe an atypical presentation of melioidosis in a 52-year-old man who had fever, right upper-abdominal pain, and jaundice for 15 days. Melioidosis caused by Burkholderia pseudomallei was subsequently diagnosed from blood culture. As a primary care physician, high suspicion index is of great importance. High suspicion index of melioidosis in a high-risk group patient, such as the patient with diabetes mellitus and diabetic foot, is crucial in view of atypical presentations of pseudomonas sepsis. A correct combination of antibiotic administration in the early phase of therapy will determine its successful outcome.Keywords: Burkholderia pseudomallei, atypical, high suspicion, primary care

  1. Impact of socio-economic class on colorectal cancer patient outcomes in Kuala Lumpur and Kuching, Malaysia.

    Science.gov (United States)

    Kong, Chee-Kwan; Roslani, April Camilla; Law, Chee-Wei; Law, Suk-Chin Diana; Arumugam, Kulenthran

    2010-01-01

    Research over the past several decades has indicated that low socioeconomic class has a direct effect on health outcomes. In Malaysia, class distribution may differ with the region. The objective of this study was to compare the presentation and survival of colorectal cancer patients in two dissimilar cities, Kuala Lumpur and Kuching, Sarawak. All patients diagnosed with a malignancy of the colon or rectum in Sarawak General Hospital and University of Malaya Medical Center from 1st Jan 2000-31st Dec 2006 were recruited. Data on presentation, socio-economic class and survival were obtained. The survival duration was categorized into more than three years or three years and less. Testing for significance was performed using the chi-square test, with p values less than 0.05 considered statistically significant. A total of 565 patients in UMMC and 642 patients in SGH had a new diagnosis of colorectal carcinoma. Patients in Kuching had a longer duration of symptoms and more advanced stage at presentation, but this was not statistically significant. Lower socio-economic class was a significant factor for late and more advanced stage at diagnosis, as well as poorer three and five year survival rates. However, survival was lower for patients in Kuching compared to Kuala Lumpur, even after matching for socio-economic class. There is near-zero awareness of colorectal cancer screening in Malaysia. These findings support reaching out to communities of lower socioeconomic backgrounds to improve the colorectal cancer survival rates.

  2. Depression and Associated Factors in Patients with Type 2 Diabetes Mellitus.

    Science.gov (United States)

    Hashim, N A; Ariaratnam, S; Salleh, M R; Said, M A; Sulaiman, A H

    2016-06-01

    To determine the prevalence of major depressive disorder and its association with socio-demographic and clinical factors in patients with type 2 diabetes mellitus. This was a cross-sectional study of patients with type 2 diabetes mellitus who attended the hospital-based primary care clinics at the University Malaya Medical Centre, Kuala Lumpur, Malaysia. The patients were interviewed using the Mini-International Neuropsychiatric Interview to diagnose depression based on the DSM-IV criteria. The socio-demographic and clinical data were obtained by interviewing the patients and subsequently verified against their respective case notes. A total of 204 patients were recruited. The prevalence of major depressive disorder was 15.7%. Major depressive disorder was significantly associated with younger age of patients (mean ± standard deviation, 57.8 ± 15.1 years, p = 0.04), younger age at diagnosis of diabetes mellitus (46.2 ± 13.0 years, p = 0.01), having secondary education (p = 0.02), and having a history of depression (p = 0.002). Multivariate analysis showed that current age (p = 0.04), duration of diabetes mellitus (p = 0.04), age at diagnosis of diabetes mellitus (p = 0.01), and secondary education (p = 0.01) were significant factors. The prevalence of major depressive disorder was high among patients with type 2 diabetes mellitus. Screening of patients with type 2 diabetes mellitus for depression should be performed periodically or routinely, especially in the primary care setting.

  3. Academic standards and changing patterns of medical school admissions: a Malaysian study.

    Science.gov (United States)

    Tan, C M

    1990-07-01

    Changing social demands made it necessary for the Medical Faculty of the University of Malaya to accommodate students with a wider range of academic experience than before. However, teachers sought to achieve comparable academic standards to those in the West by striving to maintain a close resemblance to the Western model of medical education in other respects. As a result teachers failed to adapt their teaching methods, assessment techniques and curriculum design to meet the educational needs of the students, thus compromising academic standards. Many students lack basic academic skills and do not know how to learn effectively. In order to help students overcome their learning difficulties innovative teaching was required during the first year at university, designed to foster the joint development of knowledge and basic skills. In the case of less well-prepared students who lack self-confidence, a caring and supportive learning environment is crucial to the achievement of meaningful learning. Lecturers needed to become facilitators of learning rather than transmitters of knowledge. However, teachers' objective to retain international recognition of the degree, which presumably reflected the importance of teaching, was not operationalized in terms of its incentive structure such that teachers were constrained not to try to fill the new roles demanded of them. It was assumed that academic distinction accrued through scientific research was essential for the achievement of academic excellence. However, under the prevailing circumstances the two aims were mutually exclusive and incompatible and teaching quality deteriorated.

  4. Impact of sexual health course on Malaysian university students.

    Science.gov (United States)

    Low, W Y

    2004-10-01

    A sexual health course was offered and taught by academic staff from the Faculty of Medicine, University of Malaya during semester II of every year as a university elective course to other university students apart from medical students. The course covered a wide range of topics: adolescent sexuality, family planning and pregnancy, violence against women, alternative sexual behavior, physiology of sex, sex and the disabled, gender bias in sexuality, relationship and marriage, sexual dysfunctions, clarification of sexual attitudes and STDs and AIDS. The Sexual Knowledge and Attitude Test (SKAT-II) was used to measure students' pre- and post-course scores on sexual knowledge and attitudes. Fifty-four students who completed both the pre- and post-course tests showed a significant change in sexual knowledge and their attitudes towards sexual myths and autoeroticism. Sexual knowledge was also positively correlated with age, heterosexual relations, autoeroticism and sexual myths scores. However, sexual knowledge is negatively related to religiosity and the influence of religious beliefs on one's attitudes towards sexual matters. This study showed that the sexual health course offered does have a positive impact in increasing one's knowledge and changing one's attitudes towards sexual issues.

  5. Building a DNA Barcode Reference Library for the True Butterflies (Lepidoptera) of Peninsula Malaysia: What about the Subspecies?

    Science.gov (United States)

    Wilson, John-James; Sing, Kong-Wah; Sofian-Azirun, Mohd

    2013-01-01

    The objective of this study was to build a DNA barcode reference library for the true butterflies of Peninsula Malaysia and assess the value of attaching subspecies names to DNA barcode records. A new DNA barcode library was constructed with butterflies from the Museum of Zoology, University of Malaya collection. The library was analysed in conjunction with publicly available DNA barcodes from other Asia-Pacific localities to test the ability of the DNA barcodes to discriminate species and subspecies. Analyses confirmed the capacity of the new DNA barcode reference library to distinguish the vast majority of species (92%) and revealed that most subspecies possessed unique DNA barcodes (84%). In some cases conspecific subspecies exhibited genetic distances between their DNA barcodes that are typically seen between species, and these were often taxa that have previously been regarded as full species. Subspecies designations as shorthand for geographically and morphologically differentiated groups provide a useful heuristic for assessing how such groups correlate with clustering patterns of DNA barcodes, especially as the number of DNA barcodes per species in reference libraries increases. Our study demonstrates the value in attaching subspecies names to DNA barcode records as they can reveal a history of taxonomic concepts and expose important units of biodiversity. PMID:24282514

  6. Time-dependent effect in green synthesis of silver nanoparticles

    Directory of Open Access Journals (Sweden)

    Darroudi M

    2011-04-01

    Full Text Available Majid Darroudi1,2, Mansor Bin Ahmad3, Reza Zamiri4, AK Zak5, Abdul Halim Abdullah1,3, Nor Azowa Ibrahim31Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology (ITMA, Universiti Putra Malaysia, Selangor, Malaysia; 2Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran; 3Department of Chemistry, 4Department of Physics, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia; 5Low Dimensional Materials Research Center, Department of Physics, Faculty of Science, University of Malaya, Kuala Lumpur, MalaysiaAbstract: The application of “green” chemistry rules to nanoscience and nanotechnology is very important in the preparation of various nanomaterials. In this work, we successfully developed an eco-friendly chemistry method for preparing silver nanoparticles (Ag-NPs in natural polymeric media. The colloidal Ag-NPs were synthesized in an aqueous solution using silver nitrate, gelatin, and glucose as a silver precursor, stabilizer, and reducing agent, respectively. The properties of synthesized colloidal Ag-NPs were studied at different reaction times. The ultraviolet-visible (UV-vis spectra were in excellent agreement with the obtained nanostructure studies performed by transmission electron microscopy (TEM and their size distributions. The prepared samples were also characterized by X-ray diffraction (XRD and atomic force microscopy (AFM. The use of eco-friendly reagents, such as gelatin and glucose, provides green and economic attributes to this work.Keywords: silver nanoparticles, gelatin, green chemistry, time-dependent effect, ultraviolet-visible spectra

  7. The prevalence of undernutrition upon hospitalization in children in a developing country: A single hospital study from Malaysia.

    Science.gov (United States)

    Lee, Way-Seah; Ahmad, Zulfadly

    2017-10-01

    Undernourished children who require hospital care have a longer duration of hospitalization and respond poorly to modern medical therapy. The objective of the present study was to ascertain the nutritional status of children admitted to a pediatric tertiary center in Malaysia and the risk factors leading to undernutrition upon admission. In this cross-sectional, hospital-based study, anthropometric measurements [weight, length/height, mid-upper arm circumference (MUAC), triceps skinfold thickness were performed in 285 children aged from 3 months to 15 years who were admitted to University Malaya Medical Centre, Kuala Lumpur in November 2013. Acute (wasting) and chronic (stunting) undernutrition were defined as weight-for-height (WFH) and height-for-age (HFA) standard deviation (S.D.), respectively. Underweight was defined as weight-for-age definition for acute undernutrition (HFA definition of acute undernutrition, an additional eight patients were noted to have acute undernutrition (n = 40, 14%). No significant risk factors associated with undernutrition were identified. The prevalence of undernutrition among children admitted to a tertiary hospital in Malaysia was 14%. Strategies for systematic screening and provision of nutritional support in children at risk of undernutrition as well as treatment of undernutrition in children requiring hospitalization are needed. Copyright © 2017. Published by Elsevier B.V.

  8. Nonadherence to statins: individualized intervention strategies outside the pill box

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    Lansberg P

    2018-05-01

    Full Text Available Peter Lansberg,1 Andre Lee,2 Zhen-Vin Lee,3 Kannan Subramaniam,4 Sajita Setia5 1Department of Pediatrics, University Medical Center, Groningen, the Netherlands; 2Department of Pharmacy, National University of Singapore, Singapore; 3Cardiology Unit, Department of Medicine, University Malaya Medical Centre, Kuala Lumpur, Malaysia; 4Global Medical Affairs, Asia-Pacific region, Pfizer Australia, West Ryde, NSW, Australia; 5Medical Affairs, Pfizer Pte Ltd, Singapore Abstract: Poor adherence to statin therapy is linked to significantly increased risk of cardiovascular events and death. Unfortunately, adherence to statins is far from optimal. This is an alarming concern for patients prescribed potentially life-saving cholesterol-lowering medication, especially for those at high risk of cardiovascular events. Research on statin adherence has only recently garnered broader attention; hence, major reasons unique to adherence to statin therapy need to be identified as well as suggestions for countermeasures. An integrated approach to minimizing barriers and enhancing facilitation at the levels of the patient, provider, and health system can help address adherence issues. Health care professionals including physicians, pharmacists, and nurses have an obligation to improve patient adherence, as routine care. In order to achieve sustained results, a multifaceted approach is indispensable. Keywords: cardiovascular disease, nonadherence, nocebo, myopathy, statins

  9. Heritage Landmark of the Royal Town of Klang: Balai Bomba Klang Selatan

    Science.gov (United States)

    Sulaiman, Normah; Powell, Robert

    2017-10-01

    The arrival of the British colony in Kuala Lumpur sparked a radical change in the town in terms of infrastructure and town planning. Due to the British Empire’s reign over Malaya in the advent of 20th century, the colonial architectural style has influenced a lot of important building in the royal town of Selangor. Some of the building is abandoned disrespect, disregard and it’s frightening. Many deemed historic buildings and structures disappears in exchange for modernity, which is a threat to the townscape and history. The local council of Klang aims to preserve clusters of colonial sights, place of worships, schools, and remnants of a fort that has shaped the town enabling people to be more appreciative towards it. Located in the heart of Klang town, the fire station sits next to another heritage trail icon, Raja Abdullah Warehouse. Without proper documentation and curation, the building significant will remain unknown and eventually disappear. The core of this paper will showcase the building design quality and its importance, as the first attempt to document the Balai Bomba Klang Selatan to assist in conserving its tangible and intangible qualities. The study aims to collate and document the tangible qualities of the fire station to complement the measured drawing exercise.

  10. Reporting of adverse drug reactions: predictors of under-reporting in Malaysia.

    Science.gov (United States)

    Aziz, Zoriah; Siang, Tan Ching; Badarudin, Nurul Suhaida

    2007-02-01

    Malaysia like many other countries worldwide uses spontaneous reporting systems as a mean of collecting data on suspected adverse drug reaction (ADR). However, compared to other countries, which use the system, the reporting rate in Malaysia is very low. Why some physicians do not report ADRs is not well understood. To identify factors, which would predict physicians' failure to send ADR reports. Face-to-face interview using a structured questionnaire involving physicians working at the University of Malaya Medical Centre, Malaysia. About a third of the physicians in the Centre participated. Sixty-five of the 415 approached refused to participate. A high proportion of the respondents (81.4%) indicated that they had suspected an ADR but did not report it, while about 40% of the respondents were not aware of the existence of the national reporting system in Malaysia. Logistic regression modelling identified the variable 'ADR considered to be too trivial or too well known to report' as the strongest predictor of not reporting, followed by physicians' category and uncertainty that the reaction had been definitely caused by a drug. Important predictor variables, which limit physicians from reporting ADR in Malaysia, were related to uncertainty of types of reaction to report, lack of awareness about the existence, function and purpose of national ADR reporting. The findings could be useful for planning strategies to improve the reporting rate.

  11. Building a DNA barcode reference library for the true butterflies (Lepidoptera of Peninsula Malaysia: what about the subspecies?

    Directory of Open Access Journals (Sweden)

    John-James Wilson

    Full Text Available The objective of this study was to build a DNA barcode reference library for the true butterflies of Peninsula Malaysia and assess the value of attaching subspecies names to DNA barcode records. A new DNA barcode library was constructed with butterflies from the Museum of Zoology, University of Malaya collection. The library was analysed in conjunction with publicly available DNA barcodes from other Asia-Pacific localities to test the ability of the DNA barcodes to discriminate species and subspecies. Analyses confirmed the capacity of the new DNA barcode reference library to distinguish the vast majority of species (92% and revealed that most subspecies possessed unique DNA barcodes (84%. In some cases conspecific subspecies exhibited genetic distances between their DNA barcodes that are typically seen between species, and these were often taxa that have previously been regarded as full species. Subspecies designations as shorthand for geographically and morphologically differentiated groups provide a useful heuristic for assessing how such groups correlate with clustering patterns of DNA barcodes, especially as the number of DNA barcodes per species in reference libraries increases. Our study demonstrates the value in attaching subspecies names to DNA barcode records as they can reveal a history of taxonomic concepts and expose important units of biodiversity.

  12. Time trends in upper gastrointestinal diseases and Helicobacter pylori infection in a multiracial Asian population--a 20-year experience over three time periods.

    Science.gov (United States)

    Leow, A H-R; Lim, Y-Y; Liew, W-C; Goh, K-L

    2016-04-01

    Marked epidemiological changes in upper gastrointestinal diseases and Helicobacter pylori infection have taken place in the Asian Pacific region. In particular, differences with respect to race in the multiracial Asian population in Malaysia have been important and interesting. A time trend study of upper gastrointestinal disease and H. pylori infection in three time periods: 1989-1990, 1999-2000 and 2009-2010 spanning a period of 20 years was carried out. Consecutive first time gastroscopies carried out on patients attending the University of Malaya Medical Center were studied. Diagnoses and H. pylori infection status were carefully recorded. A steady decline in prevalence of duodenal ulcer (DU) and gastric ulcer (GU) from 21.1% to 9.5% to 5.0% and from 11.9% to 9.4% to 9.9% while an increase in erosive oesophagitis (EO) from 2.0% to 8.4% to 9.5% (chi-square for trend; P Chinese and Indians but the difference over time was most marked in Malays. There was a steady decline in the proportion of patients with gastric and oesophageal cancers. Peptic ulcers have declined significantly over a 20-year period together with a decline in H. pylori infection. In contrast, a steady increase in erosive oesophagitis was observed. Gastric and oesophageal squamous cell cancers have declined to low levels. © 2016 John Wiley & Sons Ltd.

  13. Comparison of Wenner and dipole–dipole arrays in the study of an underground three-dimensional cavity

    International Nuclear Information System (INIS)

    Neyamadpour, Ahmad; Wan Abdullah, W A T; Taib, Samsudin; Neyamadpour, Behrang

    2010-01-01

    The objective of this paper was to compare Wenner and dipole–dipole configurations in delineating an underground cavity at a site near the University of Malaya, Malaysia. A three-dimensional electrical resistivity imaging survey was carried out along seven parallel lines using Wenner and dipole–dipole arrays. A three-dimensional least-squares algorithm, based on the robust inversion method, was used in the inversion of the apparent resistivity data. In the inverted model, both the horizontal and vertical extents of the anomalous zones were displayed. Results indicate the superiority of the Wenner array over the dipole–dipole array for determining the vertical distribution of the subsurface resistivity, although the dipole–dipole array produced a better lateral extent of the subsurface features. The results show that the three-dimensional electrical resistivity imaging survey using both the Wenner and dipole–dipole arrays, in combination with an appropriate three-dimensional inversion method and synthetic model analysis, can be highly useful for engineering and environmental applications, especially for underground three-dimensional cavity detection

  14. Evaluation of essential oil components from the fruit peelings of sindhri and langra varieties of mango (mangifera indica L.)

    International Nuclear Information System (INIS)

    Baloch, F. S.; Tahir, S. S.; Jilani, N. S.; Khokhar, A. L.; Rajput, M. T.

    2017-01-01

    The present study was carried out to evaluate essential oil contents found in the fruit peelings of the two varieties of Mango (Mangifera indica L.), belonging to family Anacardiaceae which is commonly called Cashew family. Genus Mangifera has about forty species in S.E. Asia and Indo Malaya region. Several Mango varieties are cultivated in many areas of Pakistan. For this study GC-MS was used for the characterization of the extracted essential oil. Two Mango varieties namely, Sindhri and Langra were selected from Mirpurkhas district. Essential oil was extracted from Mango peelings by hydro distillation method. The total 34 essential oil components ranging between 0.16-49.4% identified from the Sindhri and Langra Mango varieties. Bicyclo [4.1.0] hept-3-ene, 3, 7, 7-trimethyl-, (1S) was found abundant in both varieties with 49.46% and 47.93%, respectively. Yield of essential oil was found to be 3.25% in fresh Mango fruit peelings of Sindhri, whereas 1.04% was present in Langra variety. Result of present study indicated that peelings of Mango varieties could be used as a source of many useful components. (author)

  15. Evidence of Bacterial Biofilms among Infected and Hypertrophied Tonsils in Correlation with the Microbiology, Histopathology, and Clinical Symptoms of Tonsillar Diseases

    Directory of Open Access Journals (Sweden)

    Saad Musbah Alasil

    2013-01-01

    Full Text Available Diseases of the tonsils are becoming more resistant to antibiotics due to the persistence of bacteria through the formation of biofilms. Therefore, understanding the microbiology and pathophysiology of such diseases represent an important step in the management of biofilm-related infections. We have isolated the microorganisms, evaluated their antimicrobial susceptibility, and detected the presence of bacterial biofilms in tonsillar specimens in correlation with the clinical manifestations of tonsillar diseases. Therefore, a total of 140 palatine tonsils were collected from 70 patients undergoing tonsillectomy at University Malaya Medical Centre. The most recovered isolate was Staphylococcus aureus (39.65% followed by Haemophilus influenzae (18.53%. There was high susceptibility against all selected antibiotics except for cotrimoxazole. Bacterial biofilms were detected in 60% of patients and a significant percentage of patients demonstrated infection manifestation rather than obstruction. In addition, an association between clinical symptoms like snore, apnea, nasal obstruction, and tonsillar hypertrophy was found to be related to the microbiology of tonsils particularly to the presence of biofilms. In conclusion, evidence of biofilms in tonsils in correlation with the demonstrated clinical symptoms explains the recalcitrant nature of tonsillar diseases and highlights the importance of biofilm’s early detection and prevention towards better therapeutic management of biofilm-related infections.

  16. Utilization of the emergency department by older residents in Kuala Lumpur, Malaysia.

    Science.gov (United States)

    Mohd Mokhtar, Mohd Amin; Pin, Tan Maw; Zakaria, Mohd Idzwan; Hairi, Noran Naqiah; Kamaruzzaman, Shahrul Bahiyah; Vyrn, Chin Ai; Hua, Philip Poi Jun

    2015-08-01

    To determine the pattern of utilization of emergency department (ED) services by older patients in Kuala Lumpur, Malaysia, compared with younger patients in the same setting. The sociodemographics, clinical characteristics and resource utilization of consecutive patients attending the adult ED at the University Malaya Medical Center were recorded during a typical week. A total of 1649 patients were included in the study; 422/1649 (25.6%) were aged ≥60 years and 1077 (74.4%) were aged Older adult patients were more likely to be diagnosed with ischemic heart disease (12.6% vs 2.5%, P older adults remained an independent predictor of hospital admission (OR 2.75, 95% CI 2.11-3.57). The ratio of older adult patients attending our ED over the proportion of older people in the general population was 26:6, which is far higher than reported in previous published studies carried out in other countries. Older ED attenders are also more likely to require investigations, procedures and hospital admissions. With the rapidly aging population in Malaysia, reconfiguration of resources will need to occur at a compatible rate in order to ensure that the healthcare needs of our older adults are met. © 2014 Japan Geriatrics Society.

  17. Determinants of adherence to therapies among Malaysian women with breast cancer: MyBCC Cohort

    Directory of Open Access Journals (Sweden)

    Mao Li Cheng

    2017-12-01

    Full Text Available Background: Breast cancer therapies have been progressively advancing to improve the breast cancer survival over the last few decades. However, non-adherence to cancer treatments has shown to be associated with reduced treatment effectiveness, increased mortality, and increased health care costs. The aim of the study is to understand the determinants of adherence to therapies among Malaysian breast cancer patients. Methods: This was a secondary analysis of all newly diagnosed Malaysian breast cancer patients recruited into a prospective cohort study in Universiti Malaya Medical Centre, MyBCC cohort, from 1st February 2012 to 31st December 2015. The MyBCC cohort study has ethics approval, MEC number 896.150. The treatment options (surgery, chemotherapy, radiotherapy, and overall therapies, surgical options, socio-demographic characteristics, clinical signs and symptoms, traditional and complementary medicine, and psychosocial assessments were measured using Hospital Anxiety and Depression Scale (HADS and Multidimensional Scale of Perceived Social Support (MSPSS. Results: In total, 467 patients were analysed. The adherence to surgery was 93.8%, chemotherapy 87.7%, radiotherapy 89.1%, and overall therapies 65.8% respectively. Breast conserving surgery was associated with adherence to surgery compared to mastectomy (adjusted OR 5.48 [95% CI 1.00, 30.09], p = 0.034, radiotherapy (adjusted OR 5.44 [95% CI 1.17, 25.16], p = 0.030 and overall therapies (adjusted OR 2.45 [95% CI 1.04, 5.78], p = 0.041. Time from diagnosis to surgery of less than 60 days was associated with adherence to surgery (adjusted OR 49.98 [95% CI 8.47, 289.05], p less than 0.0001 and overall therapies (adjusted OR 9.38 [95% CI 1.26, 69.73], p = 0.029. Adherence to chemotherapy associated with no surgery (adjusted OR 0.15 [95% CI 0.03, 0.70], p = 0.016. Adherence to radiotherapy was associated with financial reimbursement (adjusted OR 4.34 [95% CI 1.03, 18.26], p = 0.045 and

  18. IS IT NECESSARY TO EXCISE ALL BREAST LESIONS? EXPERIENCE FROM A UNIVERSITY-BASED BREAST UNIT

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    YIP CH

    2009-01-01

    Full Text Available Background: Breast cancer is becoming more important in Asia since it affect the younger age group. Question arises whether it is safe for breast lesions to be left in-situ if all the elements in triple assessment are benign. The aim of this study is to audit all the excision biopsies of breast lumps done in the University Malaya Medical Centre (UMMC, to review the association of age with the type of pathological finding and to evaluate the rate of carcinoma in these biopsies. Methods: We conducted a retrospective study of all women who had excision biopsy of a breast lump in the University Malaya Medical Centre from January 2005 to December 2006. All patients with malignant preoperative biopsies were excluded. Results: Of 717 lesions in 664 patients, 459 (64% were fibroadenoma, 114 (15.9% were fibrocystic disease, 20 (2.8% were phylloides tumour, 27 (3.8% were papilloma, 59 (8.2% were malignant and 38 (5.3% were of other pathology. Of the 717 open biopsies, 449 (62.6% had fine-needle aspiration cytology (FNAC, 31 (4.3% had core needle biopsy (CNB, while 14 (2.0% had both FNAC and CNB done prior to excision biopsy. 251 (35% had neither FNAC nor CNB. The incidence of fibroadenoma decreased with increasing age and the incidence of fibrocystic changes and papilloma increased with increasing age. There was no association of age with phylloides tumour. The incidence of unexpected malignancy increased with increasing age. The incidence rates were 0.3%, 4.5%, 19.4%, 29.7% and 29.6% for the age group below 30, 30-39, 40-49, 50-59 and above 60 years of age respectively. Of the 59 malignant lesions, FNAC was performed on 47 (79.7% and CNB on 16 (27.1%. 9 had both FNAC and CNB and 3 had neither FNAC nor CNB. Out of the 56 lesions where FNAC/CNB were done, 23 (41.1% were reported as benign, 20 (35.7% as suspicious, 4 (7.1% as atypical, 5 (8.9% as inadequate, 2 (3.6% as equivocal and 2 (3.6% as lymphoid lesions. Out of the 23 prior biopsies reported as

  19. Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii

    Directory of Open Access Journals (Sweden)

    Iman V

    2016-12-01

    Full Text Available Venoos Iman,1 Syam Mohan,2 Siddig Ibrahim Abdelwahab,2 Hamed Karimian,1 Noraziah Nordin,1 Mehran Fadaeinasab,3 Mohamad Ibrahim Noordin,1 Suzita Mohd Noor4 1Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Medical Research Center, Jazan University, Jazan, Saudi Arabia; 3Department of Chemistry, 4Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Abstract: Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. Murraya koenigii is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a carbazole alkaloid isolated from M. koenigii, induced apoptosis and inhibited inflammation in vitro as well as in vivo. Induction of apoptosis in human colon cancer cells (HT-29 by girinimbine revealed decreased cell viability in HT-29, whereas there was no cytotoxic effect on normal colon cells. Changes in mitochondrial membrane potential, nuclear condensation, cell permeability, and cytochrome c translocation in girinimbine-treated HT-29 cells demonstrated involvement of mitochondria in apoptosis. Early-phase apoptosis was shown in both acridine orange/propidium iodide and annexin V results. Girinimbine treatment also resulted in an induction of G0/G1 phase arrest which was further corroborated with the upregulation of two cyclin-dependent kinase proteins, p21 and p27. Girinimbine treatment activated apoptosis through the intrinsic pathway by activation of caspases 3 and 9 as well as cleaved caspases 3 and 9 which ended by triggering the execution pathway. Moreover, apoptosis was confirmed by downregulation of Bcl-2 and upregulation of Bax in girinimbine-treated cells. In addition, the key tumor suppressor protein, p53, was seen to be considerably upregulated upon girinimbine treatment. Induction of apoptosis by girinimbine was also

  20. Koenimbin, a natural dietary compound of Murraya koenigii (L Spreng: inhibition of MCF7 breast cancer cells and targeting of derived MCF7 breast cancer stem cells (CD44+/CD24-/low: an in vitro study

    Directory of Open Access Journals (Sweden)

    Ahmadipour F

    2015-02-01

    Full Text Available Fatemeh Ahmadipour,1 Mohamed Ibrahim Noordin,1 Syam Mohan,2 Aditya Arya,1 Mohammadjavad Paydar,3 Chung Yeng Looi,3 Yeap Swee Keong,4 Ebrahimi Nigjeh Siyamak,4 Somayeh Fani,1 Maryam Firoozi,5 Chung Lip Yong,1 Mohamed Aspollah Sukari,6 Behnam Kamalidehghan1 1Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Medical Research Center, Jazan University, Jazan, Kingdom of Saudi Arabia; 3Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 4UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia; 5Department of Medical Genetics, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran; 6Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Malaysia Background: Inhibition of breast cancer stem cells has been shown to be an effective therapeutic strategy for cancer prevention. The aims of this work were to evaluate the efficacy of koenimbin, isolated from Murraya koenigii (L Spreng, in the inhibition of MCF7 breast cancer cells and to target MCF7 breast cancer stem cells through apoptosis in vitro. Methods: Koenimbin-induced cell viability was evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide assay. Nuclear condensation, cell permeability, mitochondrial membrane potential, and cytochrome c release were observed using high-content screening. Cell cycle arrest was examined using flow cytometry, while human apoptosis proteome profiler assays were used to investigate the mechanism of apoptosis. Protein expression levels of Bax, Bcl2, and heat shock protein 70 were confirmed using Western blotting. Caspase-7, caspase-8, and caspase-9 levels were measured, and nuclear factor kappa B (NF-κB activity was assessed using a high-content screening assay. Aldefluor™ and mammosphere formation assays were used to evaluate the effect of koenimbin on MCF7

  1. Book Reviews

    Directory of Open Access Journals (Sweden)

    Adrianus Koster

    1981-01-01

    Full Text Available - H.J.M. Claessen, David Lewis, From Maui to Cook: The discovery and settlement of the Pacific, Drawings by Walter Stackpool. Sydney: Doubleday, 1977. Bibliography. - P. van Emst, Carl Lumholtz, Among Cannibals. An account of four years travel in Australia and of camp life with the aborigines of Queensland. Firle: Caliban Books. 383 pp. Maps, illustrations and index. Reprinted from the first edition, London: John Murray. - D.C. Geirnaert-Martin, Robert Wessing, Cosmology and social behaviour in a West Javanese settlement, Papers in International Studies, Southeast Asia Series no. 47, Ohio University Center for International Studies, Southeast Asia Program, 1978, Athens, Ohio. - B.G. Grijpstra, William Wood, Cultural-ecological perspectives in Southeast Asia, edited and with an introduction by William Wood, Papers in International Studies, Southeast Asia Studies no. 41, Ohio University Center for International Studies, Southeast Asia Program, 1977, Athens, Ohio. - R. Hagesteijn, M. Jacq-Hergoualc’h, L’armement et l’organisation de l’armée khmère aux XIIe et XIIIe siècles; d’après les bas-reliefs d’Angkor Vat, du Bayon et de Bantay Chmar. Paris: Presses Universitaires de France. - C.K. Jonker-de Putter, John Ingleson, Road to exile; The Indonesian nationalist movement, 1927-1934. ASAA Southeast Asia Publications Series, No. 1. Heinemann Educational Books (Asia Ltd., Singapore, 1979. xii + 254 blz. Bibliographie, index. - P.E. de Josselin de Jong, Roland Werner, Jah-het of Malaysia: art and culture, 1975. Kuala Lumpur: Penerbit Universiti Malaya. xxxv, 626 pp., 39 figs., 2 maps, 746 plates. - P.E. de Josselin de Jong, Roland Werner, Mah-Meri of Malaysia: Art and culture, 1974. Kuala Lumpur: Penerbit Universiti Malaya. xxvi, 485 pp., 13 figs., 3 maps, 460 plates. - Simon Kooijman, Peter Gathercole, The art of the Pacific Islands. National Gallery of Art, Washington, 1979, 365 pp., 386 illustrations + 6 sketch-maps., Adrienne L

  2. Receptor tyrosine kinase (c-Kit inhibitors: a potential therapeutic target in cancer cells

    Directory of Open Access Journals (Sweden)

    Abbaspour Babaei M

    2016-08-01

    Full Text Available Maryam Abbaspour Babaei,1 Behnam Kamalidehghan,2,3 Mohammad Saleem,4–6 Hasniza Zaman Huri,1,7 Fatemeh Ahmadipour1 1Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology (NIGEB, Shahrak-e Pajoohesh, 3Medical Genetics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Department of Urology, 5Department of Laboratory Medicine and Pathology, Masonic Cancer Center, University of Minnesota, 6Section of Molecular Therapeutics & Cancer Health Disparity, The Hormel Institute, Austin, MN, USA; 7Clinical Investigation Centre, University Malaya Medical Centre, Lembah Pantai, Kuala Lumpur, Malaysia Abstract: c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the concept that inhibiting c-Kit kinase activity can be a target for cancer therapy. The promising results of inhibition of c-Kit for treatment of cancers have been observed in some cancers such as gastrointestinal stromal tumor, acute myeloid leukemia, melanoma, and other tumors, and these results have encouraged attempts toward improvement of using c-Kit as a capable target for cancer therapy. This paper presents the findings of previous studies regarding c-Kit as a receptor tyrosine kinase and an oncogene, as well as its gene targets and signaling pathways in normal and cancer cells. The c-Kit gene location, protein structure, and the role of c-Kit in normal cell have been discussed. Comprehending the molecular mechanism underlying c-Kit-mediated tumorogenesis is consequently essential and may lead to the identification of future novel drug targets. The potential mechanisms by which c-Kit induces cellular transformation have been described. This study aims to elucidate the function of c

  3. The gastroprotective effects of hydroalcoholic extract of Monolluma quadrangula against ethanol-induced gastric mucosal injuries in Sprague Dawley rats

    Directory of Open Access Journals (Sweden)

    Ibrahim IAA

    2015-12-01

    Full Text Available Ibrahim Abdel Aziz Ibrahim,1 Mahmood Ameen Abdulla,2 Maryam Hajrezaie,2 Ammar Bader,3 Naiyer Shahzad,1 Saeed S Al-Ghamdi,1 Ahmad S Gushash,4 Mohadeseh Hasanpourghadi5 1Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; 2Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 3Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah, 4College of Arts and Science in Baljurashi, Albaha University, Baljurashi, Saudi Arabia; 5Cell Biology and Drug Discovery Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Abstract: Monolluma quadrangula (Forssk. Plowes is used in Saudi traditional medicines to treat gastric ulcers. The hydroalcoholic extract of M. quadrangula (MHAE was used in an in vivo model to investigate its gastroprotective effects against ethanol-induced acute gastric lesions in rats. Five groups of Sprague Dawley rats were used. The first group was treated with 10% Tween 20 as a control. The other four groups included rats treated with absolute ethanol (5 mL/kg to induce an ulcer, rats treated with 20 mg/kg omeprazole as a reference drug, and rats treated with 150 or 300 mg/kg MHAE. One hour later, the rats were administered absolute ethanol (5 mL/kg orally. Animals fed with MHAE exhibited a significantly increased pH, gastric wall mucus, and flattening of the gastric mucosa, as well as a decreased area of gastric mucosal damage. Histology confirmed the results; extensive destruction of the gastric mucosa was observed in the ulcer control group, and the lesions penetrated deep into the gastric mucosa with leukocyte infiltration of the submucosal layer and edema. However, gastric protection was observed in the rats pre-fed with plant extracts. Periodic acid–Schiff staining of the gastric wall revealed a remarkably intensive uptake of magenta color in the

  4. Renal targeting potential of a polymeric drug carrier, poly-L-glutamic acid, in normal and diabetic rats

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    Chai HJ

    2017-01-01

    Full Text Available Hann-Juang Chai,1 Lik-Voon Kiew,1 Yunni Chin,1 Anwar Norazit,2 Suzita Mohd Noor,2 Yoke-Lin Lo,3,4 Chung-Yeng Looi,1 Yeh-Siang Lau,1 Tuck-Meng Lim,5 Won-Fen Wong,6 Nor Azizan Abdullah,1 Munavvar Zubaid Abdul Sattar,7 Edward J Johns,8 Zamri Chik,1 Lip-Yong Chung3 1Department of Pharmacology, 2Department of Biomedical Science, 3Department of Pharmacy, Faculty of Medicine, University of Malaya, 4School of Pharmacy, International Medical University, Kuala Lumpur, 5Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar, 6Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 7School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Malaysia; 8Department of Physiology, University College Cork, Cork, Republic of Ireland Background and purpose: Poly-L-glutamic acid (PG has been used widely as a carrier to deliver anticancer chemotherapeutics. This study evaluates PG as a selective renal drug carrier.Experimental approach: 3H-deoxycytidine-labeled PGs (17 or 41 kDa and 3H-deoxycytidine were administered intravenously to normal rats and streptozotocin-induced diabetic rats. The biodistribution of these compounds was determined over 24 h. Accumulation of PG in normal kidneys was also tracked using 5-(aminoacetamido fluorescein (fluoresceinyl glycine amide-labeled PG (PG-AF. To evaluate the potential of PGs in ferrying renal protective anti-oxidative stress compounds, the model drug 4-(2-aminoethylbenzenesulfonyl fluoride hydrochloride (AEBSF was conjugated to 41 kDa PG to form PG-AEBSF. PG-AEBSF was then characterized and evaluated for intracellular anti-oxidative stress efficacy (relative to free AEBSF.Results: In the normal rat kidneys, 17 kDa radiolabeled PG (PG-Tr presents a 7-fold higher, while 41 kDa PG-Tr shows a 15-fold higher renal accumulation than the free radiolabel after 24 h post injection. The accumulation of PG-AF was primarily found in the renal tubular

  5. Neurite outgrowth stimulatory effects of myco­synthesized AuNPs from Hericium erinaceus (Bull.: Fr. Pers. on pheochromocytoma (PC-12 cells

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    Raman J

    2015-09-01

    Full Text Available Jegadeesh Raman,1 Hariprasath Lakshmanan,1 Priscilla A John,1,2 Chan Zhijian,3 Vengadesh Periasamy,3 Pamela David,1,4 Murali Naidu,1,4 Vikineswary Sabaratnam1,2 1Mushroom Research Centre, 2Institute of Biological Sciences, Faculty of Science, University of Malaya, 3Low Dimensional Materials Research Center (LDMRC, Department of Physics, Faculty of Science, 4Department of Anatomy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Background: Hericium erinaceus has been reported to have a wide range of medicinal properties such as stimulation of neurite outgrowth, promotion of functional recovery of axonotmetic peroneal nerve injury, antioxidant, antihypertensive, and antidiabetic properties. In recent years, the green synthesis of gold nanoparticles (AuNPs has attracted intense interest due to the potential use in biomedical applications. The aim of this study was to investigate the effects of AuNPs from aqueous extract of H. erinaceus on neurite outgrowth of rat pheochromocytoma (PC-12 cells. Methods: The formation of AuNPs was characterized by UV–visible spectrum, energy dispersive X-ray (EDX, field-emission scanning electron microscope (FESEM, transmission electron microscopy (TEM, particle size distribution, and Fourier transform-infrared spectroscopy (FTIR. Furthermore, the neurite extension study of synthesized AuNPs was evaluated by in vitro assay. Results: The AuNPs exhibited maximum absorbance between 510 and 600 nm in UV–visible spectrum. FESEM and TEM images showed the existence of nanoparticles with sizes of 20–40 nm. FTIR measurements were carried out to identify the possible biomolecules responsible for capping and efficient stabilization of the nanoparticles. The purity and the crystalline properties were confirmed by EDX diffraction analysis, which showed strong signals with energy peaks in the range of 2–2.4 keV, indicating the existence of gold atoms. The synthesized AuNPs showed significant neurite

  6. The accuracy and safety of fluoroscopically guided percutaneous pedicle screws in the lumbosacral junction and the lumbar spine: a review of 880 screws.

    Science.gov (United States)

    Chiu, C K; Kwan, M K; Chan, C Y W; Schaefer, C; Hansen-Algenstaedt, N

    2015-08-01

    We undertook a retrospective study investigating the accuracy and safety of percutaneous pedicle screws placed under fluoroscopic guidance in the lumbosacral junction and lumbar spine. The CT scans of patients were chosen from two centres: European patients from University Medical Center Hamburg-Eppendorf, Germany, and Asian patients from the University of Malaya, Malaysia. Screw perforations were classified into grades 0, 1, 2 and 3. A total of 880 percutaneous pedicle screws from 203 patients were analysed: 614 screws from 144 European patients and 266 screws from 59 Asian patients. The mean age of the patients was 58.8 years (16 to 91) and there were 103 men and 100 women. The total rate of perforation was 9.9% (87 screws) with 7.4% grade 1, 2.0% grade 2 and 0.5% grade 3 perforations. The rate of perforation in Europeans was 10.4% and in Asians was 8.6%, with no significant difference between the two (p = 0.42). The rate of perforation was the highest in S1 (19.4%) followed by L5 (14.9%). The accuracy and safety of percutaneous pedicle screw placement are comparable to those cited in the literature for the open method of pedicle screw placement. Greater caution must be taken during the insertion of L5 and S1 percutaneous pedicle screws owing to their more angulated pedicles, the anatomical variations in their vertebral bodies and the morphology of the spinal canal at this location. ©2015 The British Editorial Society of Bone & Joint Surgery.

  7. Economic evaluations of personalized medicine: existing challenges and current developments

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    Shabaruddin FH

    2015-06-01

    Full Text Available Fatiha H Shabaruddin,1 Nigel D Fleeman,2 Katherine Payne3 1Department of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia; 2Liverpool Reviews and Implementation Group (LRiG, University of Liverpool, Liverpool, UK; 3Institute of Population Health, The University of Manchester, Manchester, UK Abstract: Personalized medicine, with the aim of safely, effectively, and cost-effectively targeting treatment to a prespecified patient population, has always been a long-time goal within health care. It is often argued that personalizing treatment will inevitably improve clinical outcomes for patients and help achieve more effective use of health care resources. Demand is increasing for demonstrable evidence of clinical and cost-effectiveness to support the use of personalized medicine in health care. This paper begins with an overview of the existing challenges in conducting economic evaluations of genetics- and genomics-targeted technologies, as an example of personalized medicine. Our paper illustrates the complexity of the challenges faced by these technologies by highlighting the variations in the issues faced by diagnostic tests for somatic variations, generally referring to genetic variation in a tumor, and germline variations, generally referring to inherited genetic variation in enzymes involved in drug metabolic pathways. These tests are typically aimed at stratifying patient populations into subgroups on the basis of clinical effectiveness (response or safety (avoidance of adverse events. The paper summarizes the data requirements for economic evaluations of genetics and genomics-based technologies while outlining that the main challenges relating to data requirements revolve around the availability and quality of existing data. We conclude by discussing current developments aimed to address the challenges of assessing the cost-effectiveness of genetics and genomics-based technologies, which revolve around two central issues that are

  8. Exophytic oral verrucous hyperplasia: a new entity.

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    Patil, Shankargouda; Warnakulasuriya, Saman; Raj, Thirumal; Sanketh, D S; Rao, Roopa S

    2016-11-01

    Exophytic oral verrucous hyperplasia (OVH) is a new entity described by an expert working group from South Asia. First reported in Taiwan, there are no reports so far from an Indian population. The aim was to use the microscopic features described by the expert group to differentiate OVH from other oral verruco-papillary lesions in an Indian archive. In a retrospective multicentre study, using pathology archives, 188 verruco-papillary lesions were retrieved from pathology archives. A proforma listing histopathological criteria for OVH based on published guidelines (Annals of Dentistry, University of Malaya, 2013) was used. Patients' demographic and clinical data were transcribed from patient charts. The Pearson chi-square test was used to determine associations between clinical and histopathological features. Of 188 oral verruco-papillary lesions that were evaluated, based on microscopic features the cases were reclassified as OVH (57), verrucous carcinoma (VC) (84), oral squamous cell carcinoma (16), and other verruco-papillary lesions (31). Both OVH (70%) and VC (60%) showed male predominance and commonly affected buccal mucosa (OVH 74% and VC 57%). Absence of downward growth of the hyperplastic epithelium into lamina propria when compared with the level of the basement membrane of the adjacent normal epithelium was a distinct feature in OVH. Keratin plugging, epithelial dysplasia and subepithelial lymphocytic infiltration were found to be significantly different (P < 0.05) in OVH versus VC. The sample size of other verruco-papillary lesions was insufficient for statistical comparison. Apart from the absence of an endophytic growth pattern in OVH, we noted the presence of dysplasia in OVH. This significant observation does institute a debate as to whether this enigmatic lesion could possibly be a precedent of oral squamous or verrucous carcinoma. We propose OVH is a distinct entity in our Indian population and should be considered in the classification of oral

  9. Analysis of dental erosion induced by different beverages and validity of equipment for identifying early dental erosion, in vitro study.

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    Jameel, Rafey Ahmad; Khan, Shah Salman; Abdul Rahim, Zubaidah Hj; Bakri, Marina Mohd; Siddiqui, Saima

    2016-07-01

    To understand early dental erosion induced by different beverages and the equipment for its detection. The study was conducted at the University Malaya Medical Centre, Kuala Lumpur, Malaysia, from June to September 2014, and comprised single-rooted, unpolished teeth divided into six groups. Electron micrographs and other baseline readings for further analyses were taken before and after the exposure to different beverages. The teeth were exposed to the beverages using a modified Nordini's artificial mouth model. The positioning of the teeth on the motorised stage of the equipment was standardised. Of the several beverages used, CocaCola had the lowest pH value of 2.53, while tap water had the highest pH of 5.4. Deionised distilled water, which was used as a reference, had a pH near to neutral /alkaline of 7.3. The fluoride content ranged between 9.38ppm in tea and 0.005ppm in orange juice. Teeth exposed to beverages with low pH and considerably high fluoride underwent slight remineralisation (roughness increase 8% from tea), while beverages with no fluoride content and low pH roughened the enamel surface (Coca Cola roughened upto 37%). Quantitative analyses of tooth erosion, micro-hardness, surface-roughness, and surface-height showed that all beverages exhibited positive erosive effect on the tooth enamel surface (pCocaCola was found to be the most erosive agent among both hot and cold beverages (37%), while coffee was more erosive among the hot beverages (29%).

  10. Book Reviews

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    Malcom W. Mintz

    1997-01-01

    Full Text Available - Peter Boomgaard, Simone Prodolliet, Händlerinnen, Goldgr��ber und Staatsbeamte; Sozialgeschichte einer Kleinstadt im Hochland Südwestsumatras. Berlin: Reimer, 1996, 372 pp. [Berner Sumatra-Forschungen.] - Richard Chauvel, Antje van der Hoek, Religie in Ballingschap; Institutionalisering en Leiderschap onder Christelijke en Islamitische Molukkers in Nederland. Amsterdam: VU Uitgeverij, 1994, 297 pp. - J.E. Lelijveld, Kees Groeneboer, Weg tot het Westen; Het Nederlands voor Indië 1600-1950. Leiden: KITLV Uitgeverij, 1993, xii + 580 pp. - Bernd Nothofer, P.W. Martin, Language Use & Language Change in Brunei Darussalam, Athens, OH: Ohio University Center for International Studies, 1996, xvi + 373 pp. [Monographs in International Studies 100.], C. Ozog, G. Poedjosoedarmo (eds. - Anton Ploeg, Pamela Swadling, Plumes from Paradise; Trade cycles in outer Southeast Asia and their impact on New Guinea and nearby islands until 1920. With contributions by Roy Wagner and Billai Laba. Boroko/Coorparoo (Qld: Papua New Guinea National Museum in association with R. Brown & Ass. (Qld, 1996, 352 pp. Plates, maps, index. - Bernard Sellato, Traude Gavin, The women’s warpath; Iban ritual fabrics from Borneo, Los Angeles: UCLA Fowler Museum of Cultural History, 1996, 99 pp. - Jyh Wee Sew, Malcom W. Mintz, A course in conversational Indonesian (with equivalent Malay vocabulary. Singapore: EPB Publishers, 1994, 558 pp. - Kees Snoek, Liesbeth Dolk, Twee Zielen, Twee Gedachten; Tijdschriften en Intellectuelen op Java (1900-1957, Leiden: KITLV Uitgeverij, 1993, 220 pp. - Nicholas Tarling, Paul H. Kratoska, Malaya and Singapore during the Japanese Occupation. Singapore: National University of Singapore, 1995, xii + 175 pp. [Journal of Southeast Asian Studies Special Publications Series 3.

  11. Geophysicists

    Science.gov (United States)

    William W. Fox, Jr., has been appointed director of the Cooperative Institute for Marine and Atmospheric Studies (CIMAS). He had been director of the Southeast Fisheries Center of the National Marine Fisheries Service since 1978. CIMAS was established in 1977 by the National Oceanic and Atmospheric Administration and the University of Miami.Seven of the 689 U.S. Fulbright Scholars for 1982-1983 are lecturing and conducting advanced research in geology in universities abroad. Brian Francis Farrell, a research assistant in planetary studies at Harvard University, is lecturing in oceanography at the University of Cambridge in England through June. William B. Fergusson, associate professor of civil engineering at Villanova University, will lecture in geology at the Kangwon National University in Korea until July. Ray Edward Ferrell, Jr., geology chairman at Louisiana State University in Baton Rouge, lectured and conducted research in marine geology at the University of Oslo in Norway. M. Allan Kays, professor of geology at the University of Oregon in Eugene, will conduct research in geology at the University of Copenhagen in Denmark through April. Richard Vernon McGehee, associate professor of health education at Southeastern Louisiana University (University Station campus), will be lecturing in geology at the University of Monrovia in Liberia through July. Bruce Warren Nelson, a professor of environmental studies at the University of Virginia in Charlottesville, will be lecturing in geology at the Universiti Malaya in Malaysia through April. Ronald Porter Willis, professor of geology at the University of Wisconsin—Eau Claire, will be lecturing in geology at the Seoul National University in Korea through July.

  12. Pengajaran Bahasa Melayu sebagai Bahasa Asing kepada Pelajar dari Negara China : Perkongsian Pengalaman di Universiti Sains Malaysia

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    Mazlina Baharudin

    2015-06-01

    Full Text Available Universiti Sains Malaysia (USM is one of the earliest public university which was established in Malaysia after Universiti Malaya. USM is also the first university that has been given the Apex status in Malaysia which is the highest recognition  and trust granted by the Ministry of Higher Education Malaysia to USM. USM has received students from different countries such as China, Libya, Sudan, Egypt, Nigeria, Indonesia, Thailand, Japan, Korea and other countries. However, this research focuses only on the international students from China who were registered as undergraduates in USM. This paper is based on the writer’s experiences in  teaching Bahasa Malaysia III (LKM 300 as a university course that the students must pass as a requirement for international students to graduate. The main dimension of this research is to examine the effectiveness of teaching Malay language as a foreign language to international students (China by using a teaching model that uses the Bahasa Malaysia III (LKM300 course module as determined by the School of Languages, Literacies and Translation. The research method used is full literature where the writers had referred to 43 international student’s final exam scripts that have taken the LKM300 course in the first semester of the 2012/2013 academic session. Their final exam result was taken for full analysis based on the different sections in the exam paper to be used as a source to conclude the research. This research is hoped to be able to provide an explanation of the effective results of the successful usage of the course module and students’ achievement.

  13. A qualitative study on hypertensive care behavior in primary health care settings in Malaysia

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    Shima R

    2014-11-01

    Full Text Available Razatul Shima,1,3 Mohd Hairi Farizah,1,2 Hazreen Abdul Majid1,2 1Department of Social and Preventive Medicine; 2Centre for Population Health, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 3Ministry of Health Malaysia, Putrajaya, Malaysia Purpose: The aim of this study was to explore patients’ experiences with their illnesses and the reasons which influenced them in not following hypertensive care recommendations (antihypertensive medication intake, physical activity, and diet changes in primary health clinic settings. Patients and methods: A qualitative methodology was applied. The data were gathered from in-depth interviews with 25 hypertensive patients attending follow-up in nine government primary health clinics in two districts (Hulu Langat and Klang in the state of Selangor, Malaysia. The transcribed data were analyzed using thematic analysis.Results: There was evidence of lack of patient self-empowerment and community support in Malaysian society. Most of the participants did not take their antihypertensive medication or change their physical activity and diet after diagnosis. There was an agreement between the patients and the health care professionals before starting the treatment recommendation, but there lacked further counseling and monitoring. Most of the reasons given for not taking antihypertensive medication, not doing physical activity and not following diet recommendations were due to side effects or fear of the side effects of antihypertensive medication, patients’ attitudes, lack of information from health care professionals and insufficient social support from their surrounding environment. We also observed the differences on these reasons for nonadherence among the three ethnic groups.Conclusion: Health care professionals should move toward supporting adherence in the management of hypertensive patients by maintaining a dialogue. Patients need to be given time to enable them to overcome their

  14. Book Reviews

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    Andrew Sharp

    1961-10-01

    Full Text Available - P. Voorhoeve, Tudjimah, Asrar al-insan fi maýrifa al-ruh waýl-Rahman. Tesis Djakarta, 1961. 477 blz. - F.D.K. Bosch, Alastair Lamb, Chandi Bukit Batu Pahat. Three Additional Notes. 14 pp., 2 figs., 21 pls; Monographs....(etc. No. 5, 1961. - F.D.K. Bosch, Alistair Lamb, Chandi Bukit Batu Pahat; a Report on the Excavation of an Ancient Temple in Kedah. 108 pp., 40 figs., 179 pls; Monographs on Southeast Asian Subjects No. 1, Eastern Universities Press Ltd., Singapore, 1960. - T.J. Brasser, Frederick J. Dockstader, Indian art in America - The arts and crafts of the North American Indian. New York Graphic Society, Greenwich, Mass., U.S.A. 1961. 224 pages, 70 color plates, 180 black and white illustrations. - J. Prins, Cora Vreede-De Steurs, Lýýmancipation de la femme indonýsienne. Mouton & Co, Den Haag en Parijs. 174 blz., 21 platen, 1 kaart. - Clifford Geertz, Bali, Studies in Life, Thought and Ritual; Selected Studies on Indonesia, Vol. 5. W. van Hoeve, The Hague & Bandung 1960. 368 pp. text. - Tjan Giok Bwee, D.E. Wilmott, The Chinese of Semarang: a changing minority community in Indonesia. Ithaca, New York, Cornell University Press, 1960, 366 pp. - P. Gregorius, J. de Leeuwe, Groepshuwelijk en enkelvoudig huwelijk, Uitgeverij L. Stafleu & Zoon, Leiden 1960, 136 blz. - P. van Emst, Andrew Sharp, The discovery of the Pacific Islands. Clarendon Press: Oxford University Press. Oxford 1960. 259 pp. - T. Volker, John Bastin, The changing balance of the early Southeast Asian pepper trade (Papers on Southeast Asian subjects No 1. Department of History University of Malaya in Kuala Lumpur, 1960. 60 pp. text, maps, bibliog. - W.F. Wertheim, Leslie H. Palmier, Social status and power in Java. London School of Economics Monographs on Social Anthropology, no. 20. London, 1960. 165 blz.

  15. La situación actual de la población china en Malasia

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    Enrique Díaz Larrea

    2013-02-01

    Full Text Available Malasia país estratégico en el comercio internacional, rico en materias primas y una sociedad multiétnica que en muchas ocasiones se quiere ver como modélica para las potencias emergentes. El factor determinante que ha configurado esta nación ha sido la presencia en suelo de una diversa y poderosa comunidad china. Es una de las comunidades chinas de ultramar más antiguas del mundo. Su origen se remonta a principios del siglo XIX y la corriente migratoria aún no se ha detenido. Por tanto la comunidad china de Malasia es muy variada. Por otro lado, posee un enorme poder económico que ha hecho necesarias por parte del estado malasio de la implementación de políticas proteccionistas hacia la población mayoritaria del país (malaya y musulmana. _________________ Abstract: Malaysia is a strategic country in international trading, rich in raw materials and a multiethnic society. It is a model for emerging powers. The determining factor that set this nation has been the presence in soil of a diverse and powerful Chinese community. It is one of the overseas Chinese communities the world's oldest. It dates back to the early nineteenth century and the migration flow has not stopped yet. Thus the Malaysian Chinese community is very diverse. On the other hand, has enormous economic power that has made necessary by the Malaysian state of implementing protectionist policies towards the majority population of the country (Malay and Muslim.

  16. Health-related quality of life among colorectal cancer patients in Malaysia: a study protocol

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    Magaji Bello

    2012-09-01

    Full Text Available Abstract Background Colorectal cancer is a major public health problem in Malaysia. However, it is also one of the most treatable cancers, resulting in significant numbers of survivors. Therefore, the impact of surviving treatment for colorectal cancer on health related quality of life is important for the patients, clinicians and policy makers, and may differ in different cultures and populations. The aim of this study was to validate the Malaysian versions of the European Organization for Research and Treatment of Cancer quality of life instruments among colorectal cancers patients. Methods/design This is a cross sectional multi centre study. Three hospitals were included, the University of Malaya Medical Centre, the Universiti Kebangsaan Malaysia Medical Centre and Hospital Tuanku Jaafar Seremban. Malaysian citizens and permanent residence were studied and demographic and clinical information obtained from hospital records. The European Organization for Research and Treatment of Cancer Quality of life Core 30, colorectal cancer CR29, and the colorectal cancer liver metastasis LMC 21 were used and an observer assessment of performance obtained with the Karnofsky Performance Scale. Questionnaires were translated into three most commonly spoken languages in Malaysia (Bahasa Malaysia, Chinese and Tamil, then administered, scored and analyzed following the developers’ guidelines. Ethical approval was obtained from the participating centres. Tests of reliability and validity were performed to examine the validity of these instruments. Conclusion The result of pilot testing shows that the use of the Malaysian versions of EORTC QLQ C30, CR29 instruments is feasible in our sample of colorectal cancer patients. Instructions for completion as well as questions were well understood except the questions on the overall quality of life, overall health status and sexual activity. Thus we anticipate obtaining good psychometric properties for the instruments

  17. Skills Development in The Asia-Pacific Maritime World: A Comparative Study of Vocational Education in Malaysia and Indonesia

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    Ramlee Mustapha

    2017-07-01

    Full Text Available This region of Southeast Asia shares more social and cultural ties with other Austronesian peoples in the Pacific than with the peoples of mainland Southeast Asia. Contemporarily, Asia Pacific is still the fastest growing economic region in the world despite economic turbulence and uncertainties in recent years due to the global economic slow-down.  As one of centres of economic power, the region could hardly remain immune to the globalizing impact of economic and technological change. The purpose of this study was to explore the development of Technical and Vocational education in Malaysia and Indonesia by analyzing the history, policies, and its direction. In Malaya, the Technical and Vocational education prior to independence had projected the images of “colonial apprenticeship” with the emphasis on manual agricultural and crafts, which aimed at training the Malay students to fill positions in the Railway department under the Federated Malay States. After independence, Technical and Vocational education in Malaysia continued to grow, and some reforms have been implemented to improve the image of Technical and Vocational education itself.  In Indonesia, a similar development occurred but the difference is in terms of Technical and Vocational education funding at the secondary level where there are many private Technical and Vocational schools as compared to Malaysia.  There are new concepts introduced in Technical and Vocational education, such as the Tech-Prep, Time Sector Privatization and Vocational Colleges in Malaysia and Link and Match, Dual System, Product-based Curriculum, and Total Performance Management (TPM in Indonesia, but the concepts are yet to be carried out optimally due of some constraints.  The implications of this study are to identify the human capital development in the maritime Archipelago countries from the perspectives of the competitiveness and the preparation for dealing with the impact of globalization.

  18. Non Goverment Organisation (NGO: Role NGOs Film in Malaysia for Literature

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    Ab Samad Kechot

    2011-09-01

    Full Text Available This writing aims to discuss the progression of several Malaysia’s film of non-governmental organizations (NGOs. It seeks to explore the history of NGOs film’s from the golden age of ‘Jalan Ampas’ to date as well as to examine the roles of these organizations played in the film industry. This paper also a part of a Master’s research entitled the role of Film’s Non-Governmental Organizations (NGOs Leader: study of the several NGOs. Research methods used are library research and field studies. Library research has been made for secondary data while field studies run for interview, questionnaires for NGOs members and data from NGOs reports. The data was analysed using Statistical Package for the Social Science (SPSS, as for interview was conducted among the leaders of selective NGOs and also on the opinion leader who are a film activists. However, this study is limited to a few selected NGOs film only. Findings of this study found that the Association of Film Artists of Malaya (PERSAMA is the pioneer for NGOs film’s and a basic struggle for workers move in the film based on volunteerism. At present, the observed association is actively championing the aspirations of five associations that are under the Combined Staff Association of Film Malaysia (GAFIM, Malaysian Association of Artists (SENIMAN, Malaysian Film Producers Association (PFM, Film Director Association of Malaysia (FDAM, and Screen Writers Guild of Malaysia (SWAM and Film Employees Association of Malaysia (PROFIMA.The findings of this study found that many efforts have been made to enhance the film’s quality and place more films to international level.

  19. Functional and molecular surveillance of Helicobacter pylori antibiotic resistance in Kuala Lumpur.

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    Xinsheng Teh

    Full Text Available BACKGROUND: Helicobacter pylori is the etiological agent for diseases ranging from chronic gastritis and peptic ulcer disease to gastric adenocarcinoma and primary gastric B-cell lymphoma. Emergence of resistance to antibiotics possesses a challenge to the effort to eradicate H. pylori using conventional antibiotic-based therapies. The molecular mechanisms that contribute to the resistance of these strains have yet to be identified and are important for understanding the evolutional pattern and selective pressure imposed by the environment. METHODS AND FINDINGS: H. pylori was isolated from 102 patients diagnosed with gastrointestinal diseases, who underwent endoscopy at University Malaya Medical Centre (UMMC. The isolates were tested for their susceptibility on eleven antibiotics using Etest. Based on susceptibility test, 32.3% of the isolates were found to have primary metronidazole resistance; followed by clarithromycin (6.8% and fluoroquinolones (6.8%. To further investigate the resistant strains, mutational patterns of gene rdxA, frxA, gyrA, gyrB, and 23S rRNA were studied. Consistent with the previous reports, metronidazole resistance was prevalent in the local population. However, clarithromycin, fluoroquinolone and multi-drug resistance were shown to be emerging. Molecular patterns correlated well with phenotypic data. Interestingly, multi-drug resistant (MDR strains were found to be associated with higher minimum inhibitory concentration (MIC than their single-drug resistant (SDR counterparts. Most importantly, clarithromycin-resistant strains were suggested to have a higher incidence for developing multi-drug resistance. CONCLUSION: Data from this study highlighted the urgency to monitor closely the prevalence of antibiotic resistance in the Malaysian population; especially that of clarithromycin and multi-drug resistance. Further study is needed to understand the molecular association between clarithromycin resistance and multi

  20. Psychometric Validation of the Bahasa Malaysia Version of the EORTC QLQ-CR29.

    Science.gov (United States)

    Magaji, Bello Arkilla; Moy, Foong Ming; Roslani, April Camilla; Law, Chee Wei; Raduan, Farhana; Sagap, Ismail

    2015-01-01

    This study examined the psychometric properties of the Bahasa Malaysia (BM) version of the European Organization for Research and Treatment of Cancer (EORTC) Colorectal Cancer-specific Quality Of Life Questionnaire (QLQ-CR29). We studied 93 patients recruited from University Malaya and Universiti Kebangsaan Medical Centers, Kuala Lumpur, Malaysia using a self-administered method. Tools included QLQ-C30, QLQ-CR29 and Karnofsky Performance Scales (KPS). Statistical analyses included Cronbach's alpha, test-retest correlations, multi-traits scaling and known-groups comparisons. A p value ≤ 0.05 was considered significant. The internal consistency coefficients for body image, urinary frequency, blood and mucus and stool frequency scales were acceptable (Cronbach's alpha α ≥ 0.65). However, the coefficients were low for the blood and mucus and stool frequency scales in patients with a stoma bag (α = 0.46). Test-retest correlation coefficients were moderate to high (range: r = 0.51 to 1.00) for most of the scales except anxiety, urinary frequency, buttock pain, hair loss, stoma care related problems, and dyspareunia (r ≤ 0.49). Convergent and discriminant validities were achieved in all scales. Patients with a stoma reported significantly higher symptoms of blood and mucus in the stool, flatulence, faecal incontinence, sore skin, and embarrassment due to the frequent need to change the stoma bag (p < 0.05) compared to patients without stoma. None of the scales distinguished between patients based on the KPS scores. There were no overlaps between scales in the QLQ-C30 and QLQ-CR29 (r < 0.40). the BM version of the QLQ-CR29 indicated acceptable psychometric properties in most of the scales similar to original validation study. This questionnaire could be used to complement the QLQ-C30 in assessing HRQOL among BM speaking population with colorectal cancer.

  1. Health-related quality of life among colorectal cancer patients in Malaysia: a study protocol.

    Science.gov (United States)

    Magaji, Bello Arkilla; Moy, Foong Ming; Roslani, April Camilla; Sagap, Ismail; Zakaria, Jasiah; Blazeby, Jane M; Law, Chee Wei

    2012-09-03

    Colorectal cancer is a major public health problem in Malaysia. However, it is also one of the most treatable cancers, resulting in significant numbers of survivors. Therefore, the impact of surviving treatment for colorectal cancer on health related quality of life is important for the patients, clinicians and policy makers, and may differ in different cultures and populations. The aim of this study was to validate the Malaysian versions of the European Organization for Research and Treatment of Cancer quality of life instruments among colorectal cancers patients. This is a cross sectional multi centre study. Three hospitals were included, the University of Malaya Medical Centre, the Universiti Kebangsaan Malaysia Medical Centre and Hospital Tuanku Jaafar Seremban. Malaysian citizens and permanent residence were studied and demographic and clinical information obtained from hospital records. The European Organization for Research and Treatment of Cancer Quality of life Core 30, colorectal cancer CR29, and the colorectal cancer liver metastasis LMC 21 were used and an observer assessment of performance obtained with the Karnofsky Performance Scale. Questionnaires were translated into three most commonly spoken languages in Malaysia (Bahasa Malaysia, Chinese and Tamil), then administered, scored and analyzed following the developers' guidelines. Ethical approval was obtained from the participating centres. Tests of reliability and validity were performed to examine the validity of these instruments. The result of pilot testing shows that the use of the Malaysian versions of EORTC QLQ C30, CR29 instruments is feasible in our sample of colorectal cancer patients. Instructions for completion as well as questions were well understood except the questions on the overall quality of life, overall health status and sexual activity. Thus we anticipate obtaining good psychometric properties for the instruments at the end of the study.

  2. Book Reviews

    Directory of Open Access Journals (Sweden)

    K.G. Tregonning

    1969-10-01

    Full Text Available - J. Th. Ros-Schrijvers, G.C. Mandersloot, Pakistan. Serie Land-Volk-Cultuur, Het Wereldvenster, Baarn 1968, 219 p., fotomateriaal. - J. Th. Ros-Schrijvers, Cora Vreede-De Stuers, Parda, a study of Muslim women’s life in Northern India. Van Gorcum & Comp. n.v., Assen 1968, 128 pp., fotomateriaal. - Obayashi Taryo, C. Ouwehand, Namazu-e and their themes. An interpretative approach to some aspects of Japanese folk religion. XVI, 271 pp., 10 text figures, 21 plates, 2 maps. E.J. Brill, Leiden 1964. - C. Ouwehand, Chie Nakane, Kinship and economic organization in rural Japan. London School of Economics Monographs on social anthropology No. 32. London 1967, 203 + IX pp. - O.D. van den Muijzenberg, Grant K. Goodman, Four aspects of Philippine-Japanese Relations, 1930-1940. Monograph Series no. 9, Southeast Asia Studies, Yale University, 1967. X + 237 pp. - J.M. Pluvier, John Bastin, A history of modern Southeast Asia; Colonialism, nationalism, and decolonization. Englewood Cliffs (N.J., Prentice-Hall, Inc., 1968, viii + 214 blz., bibliografie, index., Harry J. Benda (eds. - K.G. Tregonning, Journal of Southeast Asian History. Vol. x, No. 1, March 1969. “Singapore Commemorative Issue, 1819-1969. 150th Anniversary.” 191 p. - J.C. Anceaux, Rufus S. Hendon, The phonology and morphology of Ulu Muar Malay (Kuala Pilah District, Negri Sembilan, Malaya. Department of Anthropology, Yale University, New Haven 1966. (Yale University Publications in Anthropology, 70. 176 p. - Stephan A. Gasser, D. Drost, Töpferei in Afrika. Akademie-Verlag, Berlin, 1967. 289 S., 58 fig., 18 Karten, English summary.

  3. Trend and impact of international collaboration in clinical medicine papers published in Malaysia.

    Science.gov (United States)

    Low, Wah Yun; Ng, Kwan Hoong; Kabir, M A; Koh, Ai Peng; Sinnasamy, Janaki

    2014-01-01

    Research collaboration is the way forward in order to improve quality and impact of its research findings. International research collaboration has resulted in international co-authorship in scientific communications and publications. This study highlights the collaborating research and authorship trend in clinical medicine in Malaysia from 2001 to 2010. Malaysian-based author affiliation in the Web of Science (Science Citation Index Expanded) and clinical medicine journals ( n  = 999) and articles ( n  = 3951) as of 30th Oct 2011 were downloaded. Types of document analyzed were articles and reviews, and impact factors (IF) in the 2010 Journal Citation Report Science Edition were taken to access the quality of the articles. The number of publications in clinical medicine increased from 4.5 % ( n  = 178) in 2001 to 23.9 % ( n  = 944) in 2010. The top three contributors in the subject categories are Pharmacology and Pharmacy (13.9 %), General and Internal Medicine (13.6 %) and Tropical Medicine (7.3 %). By journal tier system: Tier 1 (18.7 %, n  = 738), Tier 2 (22.5 %, n  = 888), Tier 3 (29.6 %, n  = 1170), Tier 4 (27.2 %, n  = 1074), and journals without IF (2.1 %, n  = 81). University of Malaya was the most productive. Local collaborators accounted for 60.3 % and international collaborations 39.7 %. Articles with international collaborations appeared in journals with higher journal IFs than those without international collaboration. They were also cited more significantly than articles without international collaborations. Citations, impact factor and journal tiers were significantly associated with international collaboration in Malaysia's clinical medicine publications. Malaysia has achieved a significant number of ISI publications in clinical medicine participation in international collaboration.

  4. Book Reviews

    Directory of Open Access Journals (Sweden)

    P. van Emst

    1973-10-01

    Full Text Available - S.L. van der Wal, Eunice Thio, British policy in the Malay Peninsula 1880-1910. Volume I, The Southern and Central states, University of Malaya Press, Singapore, Kuala Lumpur 1969. - D.K. Bassett, C.M. Turnbull, The Straits Settlements 1826-67: Indian Presidency to Crown Colony. The Athlone Press, London 1972. pp. x, 428. - L. Sluimers, B.R. O’G. Anderson, Java in a time of revolution: Occupation and resistance 1944-1946. Ithaca enz., Cornell University Press, 1972. - C. van Dijk, Margo L. Lyon, Bases of conflict in rural Java. Research Monograph Series, Center for South and Southeast Asia Studies. University of California, Berkeley, California, December 1970. 79 p. - Brian L. Foster, H.L. Shorto, A dictionary of the Mon inscriptions from the sixth to the sixteenth centuries. London: Oxford University Press (London Oriental Series. Volume 24, 1971. 406 p. - E. Jansen Schoonhoven, Philip van Akkeren, Sri and Christ. A study of the indigenous church in East Java. Lutterworth Press, London 1970. 229 p. - P. van Emst, S.H. Udy, Work in traditional and modern society. Modernization of traditional societies series. Prentice Hall, Inc. Engelwood Cliffs, N.J., 1970. Pp. IX & 134, tables, figs. - J. van Baal, Marilyn Strathern, Women in between. Female roles in a male world: Mount Hagen, New Guinea. Seminar Press, London & New York 1972, 372 p. - P. van Emst, David Lewis, We, the navigators. The ancient art of landfinding in the Pacific. Australian National University Press, Canberra 1972. XVIII & 345 pp., 63 figs., 13 plates, 7 maps.

  5. Impact of cancer on employment: A qualitative study exploring employment changes and financial coping strategies following breast cancer

    Directory of Open Access Journals (Sweden)

    Yek-Ching Kong

    2017-12-01

    Full Text Available Background: Few studies have examined the impact of cancer diagnosis on employment among breast cancer patients. We aim to gain an in-depth understanding on the employment issues faced by breast cancer patients as well as their financial coping strategies in a multi-ethnic Asian setting. Methods: Six focus group discussions (FGDs were carried out with breast cancer patients, representing various ethnicities and socioeconomic backgrounds, who were recruited from Hospital Kuala Lumpur, a public hospital, and University Malaya Medical Centre, a public academic hospital. All FGDs were audio recorded and transcribed verbatim. Thematic content analysis was carried out using the NVivo software. Results: Majority of breast cancer patients quitted their jobs upon diagnosis of breast cancer, with many describing that their bosses were not understanding in terms of their cancer diagnosis. Those who were self-employed meanwhile reported less productivity. Patterns of financial coping strategies due to employment changes were diverse. Some patients chose to do light weight part time jobs, while others described the important role of husbands and relatives in coping with income loss. There were mixed responses regarding return to work, in which money was the major reason to return to work, while stress was cited as a barrier to not return to work. However, many reported barriers in finding a job after cancer due to discrimination against their cancer and their age. Conclusion: It is evident that a breast cancer diagnosis brings about adverse impact on employment. Multidisciplinary interventions are urgently required in Malaysia to improve the employment status of our cancer survivors including legislative reforms to prevent discrimination. This study was funded by AIA Bhd. NMRR ID: NMRR-16-2054-32802 

  6. Assessment of GHG Emission Reduction Potential from Source-separated Organic Waste (SOW) Management: Case Study in a Higher Educational Institution in Malaysia

    International Nuclear Information System (INIS)

    Ng, C.G.; Sumiani Yusoff

    2015-01-01

    In Malaysia, the greenhouse gases (GHGs) emissions reduction via composting of source-separated organic waste (SOW) in municipal solid waste (MSW) has not been assessed. Assessment of GHG emissions reduction via composting of SOW is important as environmental impacts from waste management are waste-specific and local-specific. The study presents the case study for potential carbon reduction via composting of SOW in University of Malaya (UM). In this study, a series of calculations were used to evaluate the GHG emission of different SOW management scenarios. The calculations based on IPCC calculation methods (AM0025) include GHGs emissions from land filling, fuel consumption in transportation and SOW composting activity. The methods were applied to assess the GHG emissions from five alternative SOW management scenarios in UM. From the baseline scenario (S0), a total of 1,636.18 tCO2e was generated. In conjunction with target of 22 % recycling rate, as shown in S1, 14 % reduction in potential GHG emission can be achieved. The carbon reduction can be further enhanced by increasing the SOW composting capacity. The net GHG emission for S1, S2, S3 and S4 were 1,399.52, 1,161.29, 857.70 and 1,060.48 tCO2e, respectively. In general, waste diversion for composting proved a significant net GHG emission reduction as shown in S3 (47 %), S4 (35 %) and S2 (29 %). Despite the emission due to direct on-site activity, the significant reduction in methane generation at landfill has reduced the net GHG emission. The emission source of each scenario was studied and analysed. (author)

  7. High prevalence of multidrug-resistant MRSA in a tertiary care hospital of northern India

    Directory of Open Access Journals (Sweden)

    Hare Krishna Tiwari

    2008-11-01

    Full Text Available Hare Krishna Tiwari1, Darshan Sapkota2, Malaya Ranjan Sen11Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India; 2Department of Microbiology, Universal College of Medical Sciences, Bhairahawa, NepalAbstract: Methicillin-resistant Staphylococcus aureus (MRSA is an important nosocomial and community pathogen. The objectives of this study were to estimate the prevalence of multidrug-resistant MRSA strains in clinical specimens and to investigate the sensitivity pattern of these strains against various antibiotics used for treating hospitalized and out patients. Strains were identified using standard procedures, and their sensitivity pattern was investigated using such techniques as disc diffusion, minimum inhibitory concentration (MIC, and the mecA gene PCR. Among 783 isolates of S. aureus, 301 (38.44% were methicillin-resistant, of which 217 (72.1% were found to be multidrug-resistant. Almost all MRSA strains were resistant to penicillin, 95.68% were resistant to cotrimoxazole, 92.36% were resistant to chloramphenicol, 90.7% were resistant to norfloxacin, 76.1% were resistant to tetracycline, and 75.75% were resistant to ciprofloxacin. Vancomycin was the most effective drug, with only 0.33% of MRSA strains being resistant to it. It is concluded that antibiotics other than vancomycin can be used as anti-MRSA agents after a sensitivity test so as to preclude the emergence of resistance to it and that prevailing problems in chemotherapy will escalate unless indiscriminate and irrational usage of antibiotics is checked.Keywords: multidrug-resistant MRSA, prevalence, India

  8. Heavy metals in human teeth dentine: A bio-indicator of metals exposure and environmental pollution.

    Science.gov (United States)

    Asaduzzaman, Khandoker; Khandaker, Mayeen Uddin; Binti Baharudin, Nurul Atiqah; Amin, Yusoff Bin Mohd; Farook, Mohideen Salihu; Bradley, D A; Mahmoud, Okba

    2017-06-01

    With rapid urbanization and large-scale industrial activities, modern human populations are being increasingly subjected to chronic environmental heavy metal exposures. Elemental uptake in tooth dentine is a bioindicator, the uptake occurring during the formation and mineralization processes, stored to large extent over periods of many years. The uptake includes essential elements, most typically geogenic dietary sources, as well as non-essential elements arising through environmental insults. In this study, with the help of the Dental Faculty of the University of Malaya, a total of 50 separate human teeth were collected from dental patients of various ethnicity, age, gender, occupation, dietary habit, residency, etc. Analysis was conducted using inductively coupled plasma-mass spectrometry (ICP-MS), most samples indicating the presence of the following trace elements, placed in order of concentration, from least to greatest: As, Mn, Ba, Cu, Cr, Pb, Zn, Hg, Sb, Al, Sr, Sn. The concentrations have been observed to increase with age. Among the ethnic groups, the teeth of ethnic Chinese showed marginally greater metal concentrations than those of the Indians and Malays, the teeth dentine of females generally showing greater concentrations than that of males. Greater concentrations of Hg, Cu and Sn were found in molars while Pb, Sr, Sb and Zn were present in greater concentrations in incisors. With the elevated concentration levels of heavy metals in tooth dentine reflecting pollution from industrial emissions and urbanization, it is evident that human tooth dentine can provide chronological information on exposure, representing a reliable bio-indicator of environmental pollution. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Oral candidal species among smokers and non-smokers.

    Science.gov (United States)

    Rasool, S; Siar, C H; Ng, K P

    2005-11-01

    To determine the various oral Candidal species among healthy Malaysian adults. Case-control study. This study was collaborated between the Department of Medical Microbiology, Faculty of Medicine and Department of Oral Pathology, Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia, between September 2002 till January 2004. One hundred adults (50 smokers and 50 non-smokers), aged between 40 and 70 years were studied. Swabs and carbohydrate assimilation (Saboraud Dextrose Agar, Corn Meal Agar, API 20C AUX System) were performed. Specimens were collected from dorsum of the tongue, buccal mucosa and commissures (right and left each). Colony forms were established by positive colony forming units, on SDA medium (24-48 hours). Germ tube test for (true/pseudohyphae) growth was done on Corn Meal Agar Medium. Candida biotypes were evaluated by API 20C AUX system, which had a numerical 7 digit profile, added to evaluate a definite Candida species. Thirty-five percent of Malaysian adults harbored Candida intraorally. Candidal species identified among 100 subjects had C. albicans (27) 77%, C. glabrata (3) 8%, C. famata, C. tropicalis, C. krusei, C. lusitaniae and C. guilliermondii (1) 3% each. Thirty-three positive cases comprised of 35 species i.e. two cases had two species each. Fifty seven percent of these were smokers and 43% non-smokers. These included 40% Chinese, 36% Malays and 24% Indians. Species were, however, not specified according to intra-oral sites i.e. buccal, commissural mucosa and dorsum of tongue. On this series C. albicans is the most common species found in the oral cavity of Malaysian adults. It is equally frequent in smokers and non-smokers, but showed a predilection for the ethnic Chinese group.

  10. Radiological classification of meniscocapsular tears of the anterolateral portion of the lateral meniscus of the knee

    International Nuclear Information System (INIS)

    George, J.; Packya, N.; Tan, A.H.; Paul, G.

    2000-01-01

    In an arthroscopic-MRI correlation study of acute injuries to the knee it was found that anterolateral meniscocapsular separations of the lateral aspect of the knee were missed on MRI reporting. Eighty sports-related injuries of the knee were seen by experienced orthopaedic surgeons at the University of Malaya Medical Centre and at the National Sports Centre, Malaysia from January 1996 to July 1997. Fifty of the patients were suspected to have meniscal tears that were either lateral or medial on clinical examination and they were sent for MRI. Many of these patients were tertiary referrals. Magnetic resonance imaging examinations in 27 of the 50 patients were reported as not showing any intrasubstance or obvious meniscocapsular tears, but arthroscopy performed on them revealed anterolateral meniscocapsular tears of the lateral meniscus of varying degrees in nine of these patients. In retrospect the tears could be seen on MRI, and a pattern to the tears was noted and classified as follows. Type 0, normal; type 1, torn inferior or superior meniscocapsular attachment; type 2, both meniscofemoral and meniscotibial ligaments torn but with minimal separation of meniscus and capsule by fluid or synovitis; and type 3, marked separation of meniscus and capsule by fluid (> 3 mm). Ten patients who did not undergo arthroscopy for various personal and financial reasons underwent MRI which showed type 1 and type 2 tears, and were treated conservatively. These patients were all asymptomatic after 4-6 weeks with regard to clinical signs, suggesting a lateral meniscal tear. Magnetic resonance imaging therefore does reveal minor degrees of meniscocapsular tears anterolaterally when one understands the normal anatomy in this region. Copyright (1999) Blackwell Science Pty Ltd

  11. In silico-based vaccine design against Ebola virus glycoprotein

    Directory of Open Access Journals (Sweden)

    Dash R

    2017-03-01

    Full Text Available Raju Dash,1 Rasel Das,2 Md Junaid,3 Md Forhad Chowdhury Akash,4 Ashekul Islam,5 SM Zahid Hosen1 1Molecular Modeling and Drug Design Laboratory (MMDDL, Pharmacology Research Division, Bangladesh Council of Scientific and Industrial Research (BCSIR, Chittagong, Bangladesh; 2Nanotechnology and Catalysis Research Center, University of Malaya, Kuala Lumpur, Malaysia; 3Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh; 4Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, Bangladesh; 5Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong, Bangladesh Abstract: Ebola virus (EBOV is one of the lethal viruses, causing more than 24 epidemic outbreaks to date. Despite having available molecular knowledge of this virus, no definite vaccine or other remedial agents have been developed yet for the management and avoidance of EBOV infections in humans. Disclosing this, the present study described an epitope-based peptide vaccine against EBOV, using a combination of B-cell and T-cell epitope predictions, followed by molecular docking and molecular dynamics simulation approach. Here, protein sequences of all glycoproteins of EBOV were collected and examined via in silico methods to determine the most immunogenic protein. From the identified antigenic protein, the peptide region ranging from 186 to 220 and the sequence HKEGAFFLY from the positions of 154–162 were considered the most potential B-cell and T-cell epitopes, correspondingly. Moreover, this peptide (HKEGAFFLY interacted with HLA-A*32:15 with the highest binding energy and stability, and also a good conservancy of 83.85% with maximum population coverage. The results imply that the designed epitopes could manifest vigorous enduring defensive immunity against EBOV. Keywords: Ebola virus, epitope, glycoprotein, vaccine design

  12. Interdisciplinary and inter-institutional differences in learning preferences among Malaysian medical and health sciences students

    Directory of Open Access Journals (Sweden)

    REBECCA S.Y. WONG

    2017-10-01

    Full Text Available Introduction: The learner-centred approach in medical and health sciences education makes the study of learning preferences relevant and important. This study aimed to investigate the interdisciplinary, interinstitutional, gender and racial differences in the preferred learning styles among Malaysian medical and health sciences students in three Malaysian universities, namely SEGi University (SEGi, University of Malaya (UM and Universiti Tunku Abdul Rahman (UTAR. It also investigated the differences in the preferred learning styles of these students between high achievers and non-high achievers. Methods: This cross-sectional study was carried out on medical and health sciences students from three Malaysian universities following the approval of the Research and Ethics Committee, SEGi University. Purposive sampling was used and the preferred learning styles were assessed using the VARK questionnaire. The questionnaire was validated prior to its use. Three disciplines (medicine, pharmacy and dentistry were chosen based on their entry criteria and some similarities in their course structure. The three participating universities were Malaysian universities with a home-grown undergraduate entry medical program and students from a diverse cultural and socioeconomic background. The data were analysed using the Statistical Package for the Social Sciences (SPSS software, version 22. VARK subscale scores were expressed as mean±standard deviation. Comparisons of the means were carried out using t-test or ANOVA. A p value of 0.05. Conclusion: This study gives an insight into the learner characteristics of more than one medical school in Malaysia. Such multi-institutional studies are lacking in the published literature and this study gives a better representation of the current situation in the learning preferences among medical students in Malaysia.

  13. Health-seeking behaviour among patients with faecal incontinence in a Malaysian academic setting.

    Science.gov (United States)

    Roslani, A C; Ramakrishnan, R; Azmi, S

    2017-12-01

    Faecal incontinence (FI) is not a common presenting complaint in Malaysia, and little has been published on this topic. Since it is a treatable condition, a greater understanding of factors contributing to healthseeking behaviour is needed in order to plan effective provision of services. A survey of 1000 patients and accompanying relatives, visiting general surgical and obstetrics and gynaecology clinics for matters unrelated to FI, was conducted at University Malaya Medical Centre between January 2009 and February 2010. A follow-up regression analysis of the 83 patients who had FI, to identify factors associated with health-seeking behaviour, was performed. Variables identified through univariate analysis were subjected to multivariate analysis to determine independence. Reasons for not seeking treatment were also analysed. Only eight patients (9.6%) had sought medical treatment. On univariate analysis, the likelihood of seeking treatment was significantly higher among patients who had more severe symptoms (OR 30.0, p=0.002), had incontinence to liquid stool (OR 3.83, p=0.002) or when there was an alteration to lifestyle (OR: 17.34; p<0.001). Nevertheless, the only independently-associated variable was alteration in lifestyle. Common reasons given for not seeking treatment was that the condition did not affect patients' daily activities (88.0%), "social taboo" (5.3%) and "other" reasons (6.7%). Lifestyle alteration is the main driver of healthseeking behaviour in FI. However, the majority do not seek treatment. Greater public and physician-awareness on FI and available treatment options is needed.

  14. Interdisciplinary and inter-institutional differences in learning preferences among Malaysian medical and health sciences students.

    Science.gov (United States)

    Wong, Rebecca S Y; Siow, Heng Loke; Kumarasamy, Vinoth; Shaherah Fadhlullah Suhaimi, Nazrila

    2017-10-01

    The learner-centred approach in medical and health sciences education makes the study of learning preferences relevant and important. This study aimed to investigate the interdisciplinary, inter-institutional, gender and racial differences in the preferred learning styles among Malaysian medical and health sciences students in three Malaysian universities, namely SEGi University (SEGi), University of Malaya (UM) and Universiti Tunku Abdul Rahman (UTAR). It also investigated the differences in the preferred learning styles of these students between high achievers and non-high achievers. This cross-sectional study was carried out on medical and health sciences students from three Malaysian universities following the approval of the Research and Ethics Committee, SEGi University. Purposive sampling was used and the preferred learning styles were assessed using the VARK questionnaire. The questionnaire was validated prior to its use. Three disciplines (medicine, pharmacy and dentistry) were chosen based on their entry criteria and some similarities in their course structure. The three participating universities were Malaysian universities with a home-grown undergraduate entry medical program and students from a diverse cultural and socioeconomic background. The data were analysed using the Statistical Package for the Social Sciences (SPSS) software, version 22. VARK subscale scores were expressed as mean+standard deviation. Comparisons of the means were carried out using t-test or ANOVA. A p value of 0.05). This study gives an insight into the learner characteristics of more than one medical school in Malaysia. Such multi-institutional studies are lacking in the published literature and this study gives a better representation of the current situation in the learning preferences among medical students in Malaysia.

  15. Book Reviews

    Directory of Open Access Journals (Sweden)

    S. Kooijman

    1960-07-01

    Full Text Available - J.L. Swellengrebel, Jane Belo, Trance in Bali. Columbia University Press, New York 1960. XIII en 284 blz. tekst, 32 blz. foto’s. - P.E. de Josselin de Jong, J.M. Gullick, Indigenous Political Systems of Western Malaya. L.S.E. Monographs on Social Anthropology, no. 17. University of London, The Athlone Press, London 1958. 145 pp. - P.E. de Josselin de Jong, Judith Djamour, Malay kinship and marriage in Singapore. L.S.E. Monographs on Social Anthropology, No. 21. University of London, The Athlone Press, London 1959. 147 pp. - F.D.K. Bosch, A.J. Bernert Kempers, Ancient Indonesian Art. C.P.J. van der Peet, Amsterdam, 1959. 124 blz., 353 pl. - E.M. Uhlenbeck, M.E.J.G. Verstraelen, De bijwoordelijke bepalingen van het werkwoord in enkele Indonesische talen, diss. Utrecht 1955. - E.M. Uhlenbeck, A. Capell, A linguistic survey of the South-Western Pacific. South Pacific Commission Technical Paper no. 70, Noumea, New Caledonia, 1957. IX + 210 pp. with 17 maps. - E.M. Uhlenbeck, C. Maxwell Churchward, Tongan Grammar 1953, Tongan Dictionary 1959, Oxford University Press. - S. Kooijman, Tibor Bodrogi, Oceanian Art. With 160 photographs and 10 colour plates of objects in the custody of the Ethnographical Museum of Budapest. Budapest, 1959. - E.M. Uhlenbeck, H.R. Klieneberger, Bibliography of Oceanic Linguistics. London Oriental Bibliographies Vol. I, 1957. - W.F. Wertheim, Friedrich W. Funke, Dämmerung über Indonesien. Streifzüge durch Sumatra, Java, Bali und Celebes. Carl Schünemann Verlag, Bremen, 1959; 250 pp., 40 blz. foto’s. - G.H.R. von Koenigswald, W.E. le Gros Clark, The antecedents of man. Edinburgh University Publications, Science and Mathematics Texts 2, 1959, pp. 1-374, 152 textfiguren.

  16. The predictive accuracy of PREDICT: a personalized decision-making tool for Southeast Asian women with breast cancer.

    Science.gov (United States)

    Wong, Hoong-Seam; Subramaniam, Shridevi; Alias, Zarifah; Taib, Nur Aishah; Ho, Gwo-Fuang; Ng, Char-Hong; Yip, Cheng-Har; Verkooijen, Helena M; Hartman, Mikael; Bhoo-Pathy, Nirmala

    2015-02-01

    Web-based prognostication tools may provide a simple and economically feasible option to aid prognostication and selection of chemotherapy in early breast cancers. We validated PREDICT, a free online breast cancer prognostication and treatment benefit tool, in a resource-limited setting. All 1480 patients who underwent complete surgical treatment for stages I to III breast cancer from 1998 to 2006 were identified from the prospective breast cancer registry of University Malaya Medical Centre, Kuala Lumpur, Malaysia. Calibration was evaluated by comparing the model-predicted overall survival (OS) with patients' actual OS. Model discrimination was tested using receiver-operating characteristic (ROC) analysis. Median age at diagnosis was 50 years. The median tumor size at presentation was 3 cm and 54% of patients had lymph node-negative disease. About 55% of women had estrogen receptor-positive breast cancer. Overall, the model-predicted 5 and 10-year OS was 86.3% and 77.5%, respectively, whereas the observed 5 and 10-year OS was 87.6% (difference: -1.3%) and 74.2% (difference: 3.3%), respectively; P values for goodness-of-fit test were 0.18 and 0.12, respectively. The program was accurate in most subgroups of patients, but significantly overestimated survival in patients aged discrimination; areas under ROC curve were 0.78 (95% confidence interval [CI]: 0.74-0.81) and 0.73 (95% CI: 0.68-0.78) for 5 and 10-year OS, respectively. Based on its accurate performance in this study, PREDICT may be clinically useful in prognosticating women with breast cancer and personalizing breast cancer treatment in resource-limited settings.

  17. The predictive value of early molecular response in chronic myeloid leukaemia patients treated with imatinib in a single real-world medical centre in a developing country.

    Science.gov (United States)

    Bee, Ping Chong; Sekaran, Veera; Ng, Richard Rui Jie; Kweh, Ting Yi; Gan, Gin Gin

    2017-03-01

    The prognosis of patients with chronic myeloid leukaemia (CML) has improved since the introduction of imatinib. However, patients who do not achieve complete cytogenetic response (CCyR) and major molecular response (MMR) have poorer prognosis. Recent clinical trials have demonstrated that early and deeper cytogenetic and molecular responses predict a better long-term outcome. This study aimed to analyse the relationship between early molecular response and clinical outcome in a real-life setting. This retrospective study included all patients with CML, in chronic or accelerated phase, who were treated with imatinib at University of Malaya Medical Centre, Malaysia. A total of 70 patients were analysed. The median follow-up duration was 74 months, and the cumulative percentages of patients with CCyR and MMR were 80.0% and 65.7%, respectively. Overall survival (OS) and event-free survival (EFS) at ten years were 94.3% and 92.9%, respectively. Patients who achieved CCyR and MMR had significantly better OS and EFS than those who did not. At six months, patients who had a BCR-ABL level ≤ 10% had significantly better OS and EFS than those who had a BCR-ABL level > 10%. The target milestone of CCyR at 12 months and MMR at 18 months showed no survival advantage in our patients. Our data showed that imatinib is still useful as first-line therapy. However, vigilant monitoring of patients who have a BCR-ABL level > 10% at six months of treatment should be implemented so that prompt action can be taken to provide the best outcome for these patients. Copyright: © Singapore Medical Association

  18. Personal Continuity of Care in a University-Based Primary Care Practice: Impact on Blood Pressure Control.

    Directory of Open Access Journals (Sweden)

    Nik Sherina Hanafi

    Full Text Available Continuity of care is an important quality outcome of patient care. This study aimed to investigate the relationship between personal continuity and blood pressure (BP control among the patients with hypertension in an academic primary care centre. Between January and May 2012, we conducted a retrospective review of medical records of patients with hypertension who had been followed up for at least 1 year in the Primary Care Clinic, University of Malaya Medical Centre, Malaysia. In this setting, doctors who provided care for hypertension included postgraduate family medicine trainees, non-trainee doctors and academic staff. Systematic random sampling (1:4 was used for patient selection. BP control was defined as less than 130/80 mm Hg for patients with diabetes mellitus, proteinuria and chronic kidney disease and less than 140/90 mm Hg for all other patients. Continuity of care was assessed using the usual provider continuity index (UPCI, which is the ratio of patient visits to the usual provider to the total number of visits to all providers in 1 year. A UPC index of zero denotes no continuity while an index of one reflects perfect continuity with only the usual provider. We reviewed a total of 1060 medical records. The patients' mean age was 62.0 years (SD 10.4. The majority was women (59.2% and married (85.7%. The mean number of visits in a year was 3.85 (SD 1.36. A total of 72 doctors had provided consultations (55 postgraduate family medicine trainees, 8 non-trainee doctors and 9 academic staff. The mean UPCI was 0.43 (SD 0.34. Target BP was achieved in 42% of the patients. There was no significant relationship between BP control and personal continuity after adjustment for total number of visits. Continuity of care was not associated with BP control in our centre. Further studies are needed to explore the reasons for this.

  19. Estimates of economic burden of providing inpatient care in childhood rotavirus gastroenteritis from Malaysia.

    Science.gov (United States)

    Lee, Way Seah; Poo, Muhammad Izzuddin; Nagaraj, Shyamala

    2007-12-01

    To estimate the cost of an episode of inpatient care and the economic burden of hospitalisation for childhood rotavirus gastroenteritis (GE) in Malaysia. A 12-month prospective, hospital-based study on children less than 14 years of age with rotavirus GE, admitted to University of Malaya Medical Centre, Kuala Lumpur, was conducted in 2002. Data on human resource expenditure, costs of investigations, treatment and consumables were collected. Published estimates on rotavirus disease incidence in Malaysia were searched. Economic burden of hospital care for rotavirus GE in Malaysia was estimated by multiplying the cost of each episode of hospital admission for rotavirus GE with national rotavirus incidence in Malaysia. In 2002, the per capita health expenditure by Malaysian Government was US$71.47. Rotavirus was positive in 85 (22%) of the 393 patients with acute GE admitted during the study period. The median cost of providing inpatient care for an episode of rotavirus GE was US$211.91 (range US$68.50-880.60). The estimated average cases of children hospitalised for rotavirus GE in Malaysia (1999-2000) was 8571 annually. The financial burden of providing inpatient care for rotavirus GE in Malaysian children was estimated to be US$1.8 million (range US$0.6 million-7.5 million) annually. The cost of providing inpatient care for childhood rotavirus GE in Malaysia was estimated to be US$1.8 million annually. The financial burden of rotavirus disease would be higher if cost of outpatient visits, non-medical and societal costs are included.

  20. Rapid response to methylphenidate as an add-on therapy to mirtazapine in the treatment of major depressive disorder in terminally ill cancer patients: a four-week, randomized, double-blinded, placebo-controlled study.

    Science.gov (United States)

    Ng, Chong Guan; Boks, Marco P M; Roes, Kit C B; Zainal, Nor Zuraida; Sulaiman, Ahmad Hatim; Tan, Seng Beng; de Wit, Niek J

    2014-04-01

    This is a 4 week, randomized, double-blind, placebo-controlled study to examine the effects of methylphenidate as add-on therapy to mirtazapine compared to placebo for treatment of depression in terminally ill cancer patients. It involved 88 terminally ill cancer patients from University of Malaya Medical Centre, Kuala Lumpur, Malaysia. They were randomized and treated with either methylphenidate or placebo as add on to mirtazapine. The change in Montgomery-Åsberg Depression Rating Scale (MADRS) score from baseline to day 3 was analyzed by linear regression. Changes of MADRS and Clinical Global Impression-Severity Scale (CGI-S) over 28 days were analyzed using mixed model repeated measures (MMRM). Secondary analysis of MADRS response rates, defined as 50% or more reduction from baseline score. A significantly larger reduction of Montgomery-Åsberg Depression Rating Scale (MADRS) score in the methylphenidate group was observed from day 3 (B=4.14; 95% CI=1.83-6.45). Response rate (defined as 50% or more reduction from baseline MADRS score) in the methylphenidate treated group was superior from day 14. Improvement in Clinical Global Impression-Severity Scale (CGI-S) was greater in the methylphenidate treated group from day 3 until day 28. The drop-out rates were 52.3% in the methylphenidate group and 59.1% in the placebo group (relative risk=0.86, 95%CI=0.54-1.37) due to cancer progression. Nervous system adverse events were more common in methylphenidate treated subjects (20.5% vs 9.1%, p=0.13). In conclusions, methylphenidate as add on therapy to mirtazapine demonstrated an earlier antidepressant response in terminally ill cancer patients, although at an increased risk of the nervous system side effects. Copyright © 2014 Elsevier B.V. and ECNP. All rights reserved.

  1. The effect of selected plant extracts on the development of single-species dental biofilms

    International Nuclear Information System (INIS)

    Rahim, Z.H.; Shaikh, S.; Razak, A.; Ismail, W.N.H.W.

    2014-01-01

    To determine the effect of a mixture of plant extracts on the adherence and retention of bacteria in dental biofilm. Study Design: Experimental study. Place and Duration of Study:Department of Oral Biology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia, from December 2009 to December 2011. Methodology: For determination of adhering ability, experimental pellicle was first treated with the Plant Extracts Mixture (PEM) before inoculating it with individual bacterial species ( S. mitis / S. sanguinis / S. mutans). For the determination of retention ability, the procedure was repeated with the experimental pellicle being inoculated first with the individual bacterial species and then treating it with the PEM. These two experiments were repeated with deionized distilled water (negative control) and Thymol (0.64%) (positive control). The bacterial populations in biofilms for the two experiments were expressed as Colony Forming Unit (CFU) / mL x 10/sup 4/ and the corresponding values were expressed as mean +- SD. Results: The effect of the Plant Extracts Mixture (PEM) for the two experiments was compared with that of Thymol and deionized distilled water. It was shown that there is a reduced adherence of bacteria to PEM-treated and Thymol (0.064%) treated experimental pellicle compared with the negative control (p < 0.001). It was also found that the retention of bacteria in both treated biofilms is also lower than that of negative control (p = 0.001). Conclusion: Plant Extracts Mixture (PEM) may influence the development of dental biofilm by affecting the adhering and retention capacities of the bacterial species in the dental biofilms. (author)

  2. Range-wide latitudinal and elevational temperature gradients for the world's terrestrial birds: implications under global climate change.

    Directory of Open Access Journals (Sweden)

    Frank A La Sorte

    Full Text Available Species' geographical distributions are tracking latitudinal and elevational surface temperature gradients under global climate change. To evaluate the opportunities to track these gradients across space, we provide a first baseline assessment of the steepness of these gradients for the world's terrestrial birds. Within the breeding ranges of 9,014 bird species, we characterized the spatial gradients in temperature along latitude and elevation for all and a subset of bird species, respectively. We summarized these temperature gradients globally for threatened and non-threatened species and determined how their steepness varied based on species' geography (range size, shape, and orientation and projected changes in temperature under climate change. Elevational temperature gradients were steepest for species in Africa, western North and South America, and central Asia and shallowest in Australasia, insular IndoMalaya, and the Neotropical lowlands. Latitudinal temperature gradients were steepest for extratropical species, especially in the Northern Hemisphere. Threatened species had shallower elevational gradients whereas latitudinal gradients differed little between threatened and non-threatened species. The strength of elevational gradients was positively correlated with projected changes in temperature. For latitudinal gradients, this relationship only held for extratropical species. The strength of latitudinal gradients was better predicted by species' geography, but primarily for extratropical species. Our findings suggest threatened species are associated with shallower elevational temperature gradients, whereas steep latitudinal gradients are most prevalent outside the tropics where fewer bird species occur year-round. Future modeling and mitigation efforts would benefit from the development of finer grain distributional data to ascertain how these gradients are structured within species' ranges, how and why these gradients vary among

  3. Reliability and validity of the Malay Version of the Breast- Impact of Treatment Scale (MVBITS) in breast cancer women undergoing chemotherapy.

    Science.gov (United States)

    Zainal, Nor Zuraida; Shuib, Norley; Bustam, Anita Zarina; Sabki, Zuraida Ahmad; Guan, Ng Chong

    2013-01-01

    Body image dissatisfaction among breast cancer survivors has been associated with psychological stress resultant from breast cancer and resultant surgery. This study aimed to examine the psychometric properties of the Malay Version of the Breast-Impact of Treatment Scale (MVBITS) and to investigate the associations of retained factors with the Hospital Anxiety and Depression Scale (HADS) and the Rosenberg Self-Esteem Scale (RSES). The MVBITS was 'forward-backward' translated from English to Malay and then administered to 70 female breast cancer patients who came to the Oncology Clinic of University Malaya Medical Centre, Kuala Lumpur, Malaysia to undergo chemotherapy. Principal component analysis (PCA) with varimax rotation was performed to explore the factor structure of the MVBITS. Associations of retained factors were estimated with reference to Spearman correlation coefficients. The internal consistency reliability of MVBITS was good (Cronbach's alpha 0.945) and showed temporal stability over a 3-week period. Principal component analysis suggested two factors termed as 'Intrusion' and 'Avoidance' domains. These factors explained 70.3% of the variance. Factor 1 comprised the effects of breast cancer treatment on the emotion and thought, while Factor 2 informed attempts to limit exposure of the body to self or others. The Factor 1 of MVBITS was positively correlated with total, depression and anxiety sub-scores of HADS. Factor 2 was positively correlated with total and anxiety sub-scores of HADS. MVBITS was also positively correlated with the RSES scores. The results showed that the Malay Version of Breast-Impact of Treatment Scale possesses satisfactory psychometric properties suggesting that this instrument is appropriate for assessment of body change stress among female breast cancer patients in Malaysia.

  4. Genotype 3 is the predominant hepatitis C genotype in a multi-ethnic Asian population in Malaysia.

    Science.gov (United States)

    Ho, Shiaw-Hooi; Ng, Kee-Peng; Kaur, Harvinder; Goh, Khean-Lee

    2015-06-01

    Genotypes of hepatitis C virus (HCV) are distributed differently across the world. There is a paucity of such data in a multi-ethnic Asian population like Malaysia. The objectives of this study were to determine the distribution of HCV genotypes between major ethnic groups and to ascertain their association with basic demographic variables like age and gender. This was a cross-sectional prospective study conducted from September 2007 to September 2013. Consecutive patients who were detected to have anti-HCV antibodies in the University of Malaya Medical Centre were included and tested for the presence of HCV RNA using Roche Cobas Amplicor Analyzer and HCV genotype using Roche single Linear Array HCV Genotyping strip. Five hundred and ninety-six subjects were found to have positive anti-HCV antibodies during this period of time. However, only 396 (66.4%) were HCV RNA positive and included in the final analysis. Our results showed that HCV genotype 3 was the predominant genotype with overall frequency of 61.9% followed by genotypes 1 (35.9%), 2 (1.8%) and 6 (0.5%). There was a slightly higher prevalence of HCV genotype 3 among the Malays when compared to the Chinese (P=0.043). No other statistical significant differences were observed in the distribution of HCV genotypes among the major ethnic groups. There was also no association between the predominant genotypes and basic demographic variables. In a multi-ethnic Asian society in Malaysia, genotype 3 is the predominant genotype among all the major ethnic groups with genotype 1 as the second commonest genotype. Both genotypes 2 and 6 are uncommon. Neither genotype 4 nor 5 was detected. There is no identification of HCV genotype according to ethnic origin, age and gender.

  5. Ethnic variation of genetic (idiopathic) generalized epilepsy in Malaysia.

    Science.gov (United States)

    Lim, Kheng Seang; Ng, Ching Ching; Chan, Chung Kin; Foo, Wee Shean; Low, Joyce Siew Yong; Tan, Chong Tin

    2017-02-01

    Ethnic variation in epilepsy classification was reported in the Epilepsy Phenome/Genome Project. This study aimed to determine the ethnic variation in the prevalence of genetic (idiopathic) generalized epilepsy (GGE) and GGE with family history in a multi-ethnic Asian population in Malaysia. In this cross-sectional study, 392 patients with a clinical diagnosis of GGE were recruited in the neurology outpatient clinic, University of Malaya Medical Centre (UMMC), from January 2011 till April 2016. In our epilepsy cohort (n=2100), 18.7% were diagnosed to have GGE. Of those, 28.6% >(N=112) had family history of epilepsy with a mean age of seizure onset of 16.5 years old, and 42.0% had myoclonic seizures (N=47). The lifetime prevalence of epilepsy among first-degree relative of those with GGE and positive family history was 15.0%. Analysis according to ethnicity showed that Malaysian Chinese had the lowest percentage of GGE among those with epilepsy (12.3%), as compared with Indian and Malay (25.3% and 21.3%, pChinese (27.5%) ethnic groups. Consanguineous marriage was noted in 5 Indian families with positive family history (9.6%). There was ethnic variation in the prevalence of GGE, whereby the Malaysian Chinese had the lowest percentage of GGE as compared with Indian and Malay. A substantial proportion of GGE had positive family history among the three ethnics groups. Copyright © 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

  6. Changes in the oral health-related quality of life 24 h following insertion of fixed orthodontic appliances.

    Science.gov (United States)

    Mansor, Noorhanizar; Saub, Roslan; Othman, Siti Adibah

    2012-10-01

    The objective of this study was to assess changes in the oral health-related quality of life (OHRQoL) among patients wearing fixed orthodontic appliances 24 h after insertion. Sixty patients aged between 14 and 24 years (29 males and 31 females; mean age, 17.8 years; SD 3.1 years) were recruited from the Postgraduate Clinic, Department of Children's Dentistry and Orthodontics, Faculty of Dentistry, University of Malaya. The oral health-related quality of life (OHRQoL) was measured before treatment and 24 h after insertion of the orthodontic appliance. The instrument used to measure OHRQoL was a modified self-administered short version of Malaysian Oral Health Impact Profile (OHIP-16[M]) questionnaire. The higher the score, the poorer is the OHRQoL. Overall score of OHRQoL increased significantly 24 h after insertion (mean 43.5±10.9) as compared to before insertion (mean 34.1±9.2) (Pbad breath, difficulties in pronunciation, discomfort in eating, ulcer, pain, avoidances of eating certain foods, difficulties in cleaning, embarrassment, avoid smiling, disturbed sleep, concentration affected, difficulty carrying out daily activities, and lack of self-confidence (P<0.05). Significant changes were also found in the mean difference of OHRQoL for gender (P<0.001). OHRQoL was found to deteriorate 24 h after insertion of fixed orthodontic appliances in almost all domains, with significant changes in gender. This information can be used as "informed consent", which might increase patient's compliance as they are aware of what to expect from initial orthodontic treatment.

  7. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    1971-04-01

    Full Text Available - A.H.N. Verwey, A.J. Bernet Kempers, Borobudur: Mysteriegebeuren in steen, Verval en restauratie, Oudjavaans volksleven. Servire, Wassenaar 1970. 224 blz., 280 afb. - Graham W. Irwin, Anthony Reid, The contest for North Sumatra. Atjeh, the Netherlands and Britain 1858-1898. Kuala Lumpur and London: University of Malaya Press and Oxford University Press, 1969. 333 p., 8 plates, maps. - John Bastin, Fernand Mendes Pinto, The voyages and adventures of Fernand Mendez Pinto: Translated into English by H. Cogan 1635. Dawsons of Pall Mall. The Colonial History Series, General Editor, D.H. Simpson. London, 1969. Pages xiv + 318. - R. Roolvink, Yahya Ismail, Satu kajian mengenai karya2 Ahmad Talu. Dewan Bahasa dan Pustaka, Kuala Lumpur, 1970. XIV + 82 pp. - Harry Aveling, Umar Junus, Perkembangan puisi Melayu moden. Dewan Bahasa dan Pustaka, Kuala Lumpur 1970. XIV + 161 pp. - A.F. Ros, Clifford Geertz, Islam observed: Religious development in Morocco and Indonesia. Yale University Press, New Haven and London 1968. XII en 136 blz. - Go Gien Tjwan, Joseph-John Nevadomsky, The Chinese in Southeast Asia. A selected and annotated bibliography of publications in Western languages 1960-1970. Occasional Paper No. 6 of the Center for South and Southeast Asia Studies, University of California, Berkeley, California, 1970, 119 p., Alice Li (eds. - F.G. Bailey, S. Arasaratnam, Indians in Malaysia and Singapore. Oxford University Press for Institute of Race Relations, London 1970. 241 pp. - A.F. Marks, G.J. Kruijer, Cuba; Voorbeeld en uitdaging. Polak en Van Gennep, Amsterdam, 1968. 146 bladzijden; met foto’s. - ,

  8. Comparative analysis of essential oil composition of Iranian and Indian Nigella sativa L. extracted using supercritical fluid extraction and solvent extraction

    Directory of Open Access Journals (Sweden)

    Ghahramanloo KH

    2017-07-01

    Full Text Available Kourosh Hasanzadeh Ghahramanloo,1 Behnam Kamalidehghan,2 Hamid Akbari Javar,3 Riyanto Teguh Widodo,1 Keivan Majidzadeh,4 Mohamed Ibrahim Noordin1 1Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Medical Genetics Department, National Institute of Genetic Engineering and Biotechnology (NIGEB, 3Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS, 4Breast Cancer Research Center (BCRC Academic Center for Education, Culture and Research, Tehran, Iran Abstract: The objective of this study was to compare the oil extraction yield and essential oil composition of Indian and Iranian Nigella sativa L. extracted by using Supercritical Fluid Extraction (SFE and solvent extraction methods. In this study, a gas chromatography equipped with a mass spectrophotometer detector was employed for qualitative analysis of the essential oil composition of Indian and Iranian N. sativa L. The results indicated that the main fatty acid composition identified in the essential oils extracted by using SFE and solvent extraction were linoleic acid (22.4%–61.85% and oleic acid (1.64%–18.97%. Thymoquinone (0.72%–21.03% was found to be the major volatile compound in the extracted N. sativa oil. It was observed that the oil extraction efficiency obtained from SFE was significantly (P<0.05 higher than that achieved by the solvent extraction technique. The present study showed that SFE can be used as a more efficient technique for extraction of N. Sativa L. essential oil, which is composed of higher linoleic acid and thymoquinone contents compared to the essential oil obtained by the solvent extraction technique. Keywords: Nigella sativa L., essential oil extraction, supercritical fluid extraction, solvent extraction, fatty acid composition, thymoquinone, linoleic acid

  9. The antiulcer effect of Cibotium barometz leaves in rats with experimentally induced acute gastric ulcer

    Directory of Open Access Journals (Sweden)

    AL-Wajeeh NS

    2017-03-01

    Full Text Available Nahla Saeed Al-Wajeeh,1 Maryam Hajrezaie,1 Nawal Al-Henhena,1 Sareh Kamran,1 Elham Bagheri,1 Maryam Zahedifard,1 Kamelia Saremi,1 Suzita Mohd Noor,1 Hapipah Mohd Ali,2 Mahmood Ameen Abdulla11Department of Biomedical Science, Faculty of Medicine, 2Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, MalaysiaAbstract: Cibotium barometz is a pharmaceutical plant customarily used in traditional medicine in Malaysia for the treatment of different diseases, such as gastric ulcer. The gastroprotective effect of C. barometz leaves against ethanol-induced gastric hemorrhagic abrasions in Sprague Dawley rats has been evaluated in terms of medicinal properties. Seven groups of rats (normal control and ulcerated control groups, omeprazole 20 mg/kg, 62.5, 125, 250, and 500 mg/kg of C. barometz correspondingly were used in antiulcer experiment and pretreated with 10% Tween 20. After 1 hour, the normal group was orally administered 10% Tween 20, whereas absolute alcohol was fed orally to ulcerated control, omeprazole, and experimental groups. Gastric’s homogenate were assessed for endogenous enzymes activities. Stomachs were examined macroscopically and histologically. Grossly, the data demonstrated a significant decrease in the ulcer area of rats pretreated with plant extract in a dose-dependent manner with respect to the ulcerated group. Homogenates of the gastric tissue exhibited significantly increased endogenous enzymes activities in rats pretreated with C. barometz extract associated with the ulcerated control group. Histology of rats pretreated with C. barometz extract group using hematoxylin and eosin staining exhibited a moderate-to-mild disruption of the surface epithelium with reduction in submucosal edema and leucocyte infiltration in a dose-dependent manner. In addition, it showed heat shock protein70 protein up-expression and BCL2-associated X protein downexpression. These outcomes might be attributed to the

  10. Barriers faced by healthcare professionals when managing falls in older people in Kuala Lumpur, Malaysia: a qualitative study.

    Science.gov (United States)

    Loganathan, Annaletchumy; Ng, Chirk Jenn; Tan, Maw Pin; Low, Wah Yun

    2015-11-05

    To explore the barriers faced by healthcare professionals (HCPs) in managing falls among older people (aged above 60 years) who have a high risk of falling. The study used a qualitative methodology, comprising 10 in-depth interviews and two focus group discussions. A semistructured topic guide was used to facilitate the interviews, which were audio recorded, transcribed verbatim and checked for accuracy. Data were analysed thematically using WeftQDA software. 20 HCPs who managed falls in older people. This study was conducted at the Primary Care Clinic in the University Malaya Medical Centre (UMMC), Malaysia. Four categories of barriers emerged-these were related to perceived barriers for older people, HCPs' barriers, lack of caregiver support and healthcare system barriers. HCPs perceived that older people normalised falls, felt stigmatised, were fatalistic, as well as in denial regarding falls-related advice. HCPs themselves trivialised falls and lacked the skills to manage falls. Rehabilitation was impeded by premature decisions to admit older people to nursing homes. Lastly, there was a lack of healthcare providers as well as a dearth of fall education and training on fall prevention for HCPs. This study identified barriers that explain poor fall management in older people with a high risk of falls. The lack of structured fall prevention guidelines and insufficient training in fall management made HCPs unable to advise patients on how to prevent falls. The findings of this study warrant evidence-based structured fall prevention intervention targeted to patients as well as to HCPs. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  11. Ferulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27

    Directory of Open Access Journals (Sweden)

    Karimian H

    2014-09-01

    Full Text Available Hamed Karimian,1 Soheil Zorofchian Moghadamtousi,2 Mehran Fadaeinasab,3 Shahram Golbabapour,2 Mahboubeh Razavi,1 Maryam Hajrezaie,2 Aditya Arya,1 Mahmood Ameen Abdulla,4 Syam Mohan,5 Hapipah Mohd Ali,2 Mohamad Ibrahim Noordin1 1Department of Pharmacy, Faculty of Medicine, 2Institute of Biological Sciences, Faculty of Science, 3Department of Chemistry, 4Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, 5Medical Research Centre, Jazan University, Jazan, Saudi Arabia Abstract: Ferulago angulata is a medicinal plant that is traditionally known for its ­anti-inflammatory and antiulcer properties. The present study was aimed to evaluate its anticancer activity and the possible mechanism of action using MCF-7 as an in vitro model. F. angulata leaf extracts were prepared using solvents in the order of increasing polarity. As determined by MTT assay, F. angulata leaves hexane extract (FALHE revealed the strongest cytotoxicity against MCF-7 cells with the half maximal inhibitory concentration (IC50 value of 5.3±0.82 µg/mL. The acute toxicity study of FALHE provided evidence of the safety of the plant extract. Microscopic and flow cytometric analysis using annexin-V probe showed an induction of apoptosis in MCF-7 by FALHE. Treatment of MCF-7 cells with FALHE encouraged the intrinsic pathway of apoptosis, with cell death transducing signals that reduced the mitochondrial membrane potential with cytochrome c release from mitochondria to cytosol. The released cytochrome c triggered the activation of caspase-9. Meanwhile, the overexpression of caspase-8 suggested the involvement of an extrinsic pathway in the induced apoptosis at the late stage of treatment. Moreover, flow cytometric analysis showed that FALHE treatment significantly arrested MCF-7 cells in the G1 phase, which was associated with upregulation of p21 and p27 assessed by quantitative polymerase chain reaction. Immunofluorescence

  12. Effect of compositions in nanostructured lipid carriers (NLC on skin hydration and occlusion

    Directory of Open Access Journals (Sweden)

    Loo CH

    2012-12-01

    Full Text Available CH Loo,1,2 M Basri,2 R Ismail,1 HLN Lau,1 BA Tejo,2 MS Kanthimathi,3 HA Hassan,1 YM Choo11Malaysian Palm Oil Board, Bandar Baru Bangi, 2Department of Chemistry, Universiti Putra Malaysia, Serdang, 3Department of Molecular Medicine, University of Malaya, Kuala Lumpur, MalaysiaPurpose: To study the effects of varying lipid concentrations, lipid and oil ratio, and the addition of propylene glycol and lecithin on the long-term physical stability of nanostructured lipid nanocarriers (NLC, skin hydration, and transepidermal water loss.Methods: The various NLC formulations (A1–A5 were prepared and their particle size, zeta potential, viscosity, and stability were analyzed. The formulations were applied on the forearms of the 20 female volunteers (one forearm of each volunteer was left untreated as a control. The subjects stayed for 30 minutes in a conditioned room with their forearms uncovered to let the skin adapt to the temperature (22°C ± 2°C and humidity (50% ± 2% of the room. Skin hydration and skin occlusion were recorded at day one (before treatment and day seven (after treatment. Three measurements for skin hydration and skin occlusion were performed in each testing area.Results: NLC formulations with the highest lipid concentration, highest solid lipid concentration, and additional propylene glycol (formulations A1, A2, and A5 showed higher physical stability than other formulations. The addition of propylene glycol into an NLC system helped to reduce the particle size of the NLC and enhanced its long-term physical stability. All the NLC formulations were found to significantly increase skin hydration compared to the untreated controls within 7 days. All NLC formulations exhibited occlusive properties as they reduced the transepidermal water loss within 7 days. This effect was more pronounced with the addition of propylene glycol or lecithin into an NLC formulation, whereby at least 60% reduction in transepidermal water loss was observed

  13. Direct short-term effects of EBP teaching: change in knowledge, not in attitude; a cross-cultural comparison among students from European and Asian medical schools

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    Indah S. Widyahening

    2012-10-01

    Full Text Available Introduction: We report about the direct short-term effects of a Clinical Epidemiology and Evidence-based Medicine (CE-EBM module on the knowledge, attitude, and behavior of students in the University Medical Center Utrecht (UMCU, Universitas Indonesia (UI, and University of Malaya (UM. Methods: We used an adapted version of a 26-item validated questionnaire, including four subscales: knowledge, attitude, behavior, and future use of evidence-based practice (EBP. The four components were compared among the students in the three medical schools before the module using one-way ANOVA. At the end of the module, we measured only knowledge and attitudes. We computed Cronbach's α to assess the reliability of the responses in our population. To assess the change in knowledge and attitudes, we used the paired t-test in the comparison of scores before and after the module. Results: In total, 526 students (224 UI, 202 UM, and 100 UMCU completed the questionnaires. In the three medical schools, Cronbach's α for the pre-module total score and the four subscale scores always exceeded 0.62. UMCU students achieved the highest pre-module scores in all subscales compared to UI and UM with the comparison of average (SD score as the following: knowledge 5.04 (0.4 vs. 4.73 (0.69 and 4.24 (0.74, p<0.001; attitude 4.52 (0.64 vs. 3.85 (0.68 and 3.55 (0.63, p<0.001; behavior 2.62 (0.55 vs. 2.35 (0.71 and 2.39 (0.92, p=0.016; and future use of EBP 4.32 (0.59 vs. 4.08 (0.62 and 3.7 (0.71, p<0.01. The CE-EBM module increased the knowledge of the UMCU (from average 5.04±0.4 to 5.35±0.51; p<0.001 and UM students (from average 4.24±0.74 to 4.53±0.72; p<0.001 but not UI. The post-module scores for attitude did not change in the three medical schools. Conclusion: EBP teaching had direct short-term effects on knowledge, not on attitude. Differences in pre-module scores are most likely related to differences in the system and infrastructure of both medical schools and their

  14. Automated classification of tropical shrub species: a hybrid of leaf shape and machine learning approach.

    Science.gov (United States)

    Murat, Miraemiliana; Chang, Siow-Wee; Abu, Arpah; Yap, Hwa Jen; Yong, Kien-Thai

    2017-01-01

    Plants play a crucial role in foodstuff, medicine, industry, and environmental protection. The skill of recognising plants is very important in some applications, including conservation of endangered species and rehabilitation of lands after mining activities. However, it is a difficult task to identify plant species because it requires specialized knowledge. Developing an automated classification system for plant species is necessary and valuable since it can help specialists as well as the public in identifying plant species easily. Shape descriptors were applied on the myDAUN dataset that contains 45 tropical shrub species collected from the University of Malaya (UM), Malaysia. Based on literature review, this is the first study in the development of tropical shrub species image dataset and classification using a hybrid of leaf shape and machine learning approach. Four types of shape descriptors were used in this study namely morphological shape descriptors (MSD), Histogram of Oriented Gradients (HOG), Hu invariant moments (Hu) and Zernike moments (ZM). Single descriptor, as well as the combination of hybrid descriptors were tested and compared. The tropical shrub species are classified using six different classifiers, which are artificial neural network (ANN), random forest (RF), support vector machine (SVM), k-nearest neighbour (k-NN), linear discriminant analysis (LDA) and directed acyclic graph multiclass least squares twin support vector machine (DAG MLSTSVM). In addition, three types of feature selection methods were tested in the myDAUN dataset, Relief, Correlation-based feature selection (CFS) and Pearson's coefficient correlation (PCC). The well-known Flavia dataset and Swedish Leaf dataset were used as the validation dataset on the proposed methods. The results showed that the hybrid of all descriptors of ANN outperformed the other classifiers with an average classification accuracy of 98.23% for the myDAUN dataset, 95.25% for the Flavia dataset and 99

  15. [Taxonomy and evolution of the genus Pratylenchoides (Nematoda: Pratylenchidae)].

    Science.gov (United States)

    Ryss, A Iu

    2007-01-01

    Fagaceae, Betulaceae, and Oleaceae. The leading factor of the evolutional adaptation to soil-climatic conditions was the factor of humidity, but its significance gradually decreased with the host change to more advanced plant taxa adapted to the communities with more dry balanced humidity. The genus took its origin on the south shores of Laurasia in the Cainozoe. Later, when Hindistant and Arabian Peninsula joined with Laurasia creating the Himalayas barrier, the Pratylenchoides spp. distributed by two branches: the northern one moved into Central Asia, East Europe and North America, and the south branch came into Indo-Malaya, West Asia and the north of Africa. The remnants of the ancient species groups remain in West Europe and East Asia. In the North America the genus gave an origin to its sister genus Apratylenchoides, which spread to the south up to Antarctica; another advanced branch spread in the North America reaching Alaska.

  16. Technial Programme Committee

    Science.gov (United States)

    2014-06-01

    Associate Professor Dr Benny Peter, Universiti Teknologi Malaysia (UTM), Malaysia Associate Professor Dr Norzailawati Mohd Nor, International Islamic University Malaysia (IIUM), Malaysia Dr Josée Lévesque, Defence Research and Development Canada (DRDC), Canada Dr Ali Ariapour, Islamic Azad University, Iran Dr Zulkiflee Abd Latif, Universiti Teknologi MARA (UiTM), Malaysia Dr Lim Tien Sze, Multimedia University (MMU), Malaysia Dr Ruzinoor Che Mat, Universiti Utara Malaysia (UUM), Malaysia Dr Eran Sadek Said Md Sadek, Universiti Teknologi MARA (UiTM), Malaysia Dr Siti Khairunniza Bejo, Universiti Putra Malaysia (UPM) Dr Ramin Nourqolipour, National Organization of Forest, Range and Watershed Manage Sr Mohktar Azizi Mohd Din, Universiti Malaya Col (Rt) Frederic Hernoust, Magelli Marzieh Mokarram, University of Isf Mohd Fadhil Abuhan, Royal Malaysian Police, Malaysia

  17. Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy

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    Muthoosamy K

    2015-02-01

    Full Text Available Kasturi Muthoosamy,1 Renu Geetha Bai,1 Ibrahim Babangida Abubakar,2 Surya Mudavasseril Sudheer,1 Hong Ngee Lim,3 Hwei-San Loh,2,4 Nay Ming Huang,5 Chin Hua Chia,6 Sivakumar Manickam1 1Manufacturing and Industrial Processes Research Division, Faculty of Engineering, 2School of Biosciences, Faculty of Science, University of Nottingham Malaysia Campus, Semenyih, Selangor, Malaysia; 3Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 4Biotechnology Research Centre, University of Nottingham Malaysia Campus, Semenyih, Selangor, Malaysia; 5Low Dimension Materials Research Centre, Department of Physics, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia; 6School of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia Purpose: A simple, one-pot strategy was used to synthesize reduced graphene oxide (RGO nanosheets by utilizing an easily available over-the-counter medicinal and edible mushroom, Ganoderma lucidum. Methods: The mushroom was boiled in hot water to liberate the polysaccharides, the extract of which was then used directly for the reduction of graphene oxide. The abundance of polysaccharides present in the mushroom serves as a good reducing agent. The proposed strategy evades the use of harmful and expensive chemicals and avoids the typical tedious reaction methods. Results: More importantly, the mushroom extract can be easily separated from the product without generating any residual byproducts and can be reused at least three times with good conversion efficiency (75%. It was readily dispersible in water without the need of ultrasonication or any surfactants; whereas 5 minutes of ultrasonication with various solvents produced RGO which was stable for the tested period of 1 year. Based on electrochemical measurements, the followed method did not jeopardize RGO’s electrical conductivity. Moreover, the obtained RGO was

  18. Generic atorvastatin is as effective as the brand-name drug (LIPITOR®) in lowering cholesterol levels: a cross-sectional retrospective cohort study.

    Science.gov (United States)

    Loch, Alexander; Bewersdorf, Jan Philipp; Kofink, Daniel; Ismail, Dzafir; Abidin, Imran Zainal; Veriah, Ramesh Singh

    2017-07-17

    In a world of ever increasing health care costs, generic drugs represent a major opportunity to ensure access to essential medicines for people who otherwise would be unable to afford them. However, some clinicians and patients are still questioning the safety and effectiveness of generic formulations compared to the proprietary drugs necessitating further systematic research analyzing the generic drugs' efficacy. Our objective was to compare the lipid lowering effects of generic and branded atorvastatin. This cross-sectional, retrospective cohort study was conducted at the University of Malaya Medical Centre from 1 May 2013 until 30 May 2013. We analyzed the lipid profiles (total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides) of 629 patients before and at least 3 months after switching them from proprietary atorvastatin (Lipitor ® ) to generic atorvastatin (atorvastatin calcium from Ranbaxy Laboratories, Inc.). We also investigated if there was any difference in the effectiveness of both atorvastatin formulations in various ethnic groups. 266 patients were included in this study. When comparing the median values we found no statistically significant differences (Wilcoxon signed-rank test; p atorvastatin in lowering total cholesterol (4.60 mmol/l pre-transition vs. 4.50 mmol/l post-transition; p = 0.583), LDL-cholesterol (2.42 mmol/l vs. 2.41 mmol/l; p = 0.923) and triglycerides (1.50 mmol/l vs. 1.50 mmol/l; p = 0.513). While there was a statistically significant (p = 0.009) difference in HDL-cholesterol levels favouring proprietary atorvastatin, the extent of this change (1.26 mmol/l vs. 1.25 mmol/l) was deemed not to be clinically relevant. There was no statistically significant difference when analyzing the effects on various ethnic groups. Substituting proprietary atorvastatin for its generic formulation atorvastatin calcium does not result in a less effective management of hyperlipidemia. Our findings lend support to the

  19. Non-alcoholic fatty liver disease in diabetics--prevalence and predictive factors in a multiracial hospital clinic population in Malaysia.

    Science.gov (United States)

    Chan, Wah-Kheong; Tan, Alexander Tong-Boon; Vethakkan, Shireene Ratna; Tah, Pei-Chien; Vijayananthan, Anushya; Goh, Khean-Lee

    2013-08-01

    There is currently no published study comparing prevalence of non-alcoholic fatty liver disease (NAFLD) and associated factors among diabetics of different ethnicity in the Asia-Pacific region. Cross-sectional study of consecutive patients in the Diabetic Clinic in University of Malaya Medical Centre. The Global Physical Activity Questionnaire and a semiquantitative food-frequency questionnaire were used to assess physical activity and dietary intake, respectively. Diagnosis of NAFLD was ultrasound-based and following exclusion of significant alcohol intake. Data for 399 patients were analyzed (mean age 62.3 ± 10.5 years, 43.1% men). The racial distribution was Chinese 43.6%, Indian 33.1%, Malay 22.3%, and others 1.0%. The prevalence of NAFLD was 49.6%. On univariate analysis, factors associated with NAFLD were age obesity, central obesity, glycated hemoglobin ≥ 7.0%, and elevated serum alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase levels. Patients with low physical activity were more likely to have NAFLD (odds ratio [OR] = 1.67, 95% confidence interval [CI] = 1.06-2.63, P = 0.020). The prevalence of NAFLD was highest among Malays (60.7%), followed by Indians (51.5%), and lowest among Chinese (42.0%) consistent with higher prevalence of central obesity and higher percentage calorie intake from fat in the former groups of patients. On multivariate analysis, independent factors associated with NAFLD were central obesity (OR = 2.20, 95% CI = 1.29-3.75, P = 0.004) and elevated serum ALT level (OR = 1.98, 95% CI = 1.21-3.25, P = 0.007). NAFLD was seen in half of a cohort of diabetic patients and was independently associated with central obesity and elevated serum ALT level. Prevalence of NAFLD was different and paralleled the difference in prevalence of central obesity and in percentage calorie intake from fat among the different ethnic groups. © 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

  20. Contribution of germline TP53 variants and assessment of HER-2 status among young breast cancer patients in Malaysia

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    Shao Yan Lau

    2017-12-01

    Full Text Available Background: Li-Fraumeni Syndrome (LFS is caused by a mutation in the TP53 tumour suppressor gene. This rare hereditary condition predisposes individuals to an increased risk of cancers including breast cancer in women at a relatively young age, which accounts for nearly 25%–30% of all LFS‑associated cancers. Studies have shown that breast tumours in women with a germline TP53 deleterious variants are associated with a human epidermal growth factor receptor 2 (HER2-positive phenotype. Taken together, this study aimed to investigate the contribution of germline TP53 variants and its association with tumour HER-2 status in a cohort of young women with breast cancer. Methods: From 2002 to 2017, 4048 women with breast cancer treated at University Malaya Medical Centre or Sime Darby Medical Centre participated in the Malaysian Breast Cancer Genetics Study. Of which, 87 patients were diagnosed before 30 years of age. All patients were analysed for germline TP53 single nucleotide variants, small insertions or deletions by amplicon‑based targeted sequencing and validated by Sanger sequencing. DNA from patients who tested negative for sequencing were subsequently evaluated for the presence of TP53 exon deletions or duplications by multiplex ligation‑dependent probe amplification. HER-2 status of breast tumours was defined by immunohistochemistry, fluorescence in situ hybridisation and/or silver in situ hybridisation. Results: 5 distinct TP53 variants were detected in 5 individuals. 3 out of 5 TP53 variants were classified as frameshift mutations, one nonsense mutation and one in-frame duplication. Variants in other genes were detected in 17 individuals. No large genomic rearrangements were detected in the remaining 65 sequencing-negative patients. The assessment of HER-2 status will be presented. Conclusions: Our results suggest that alterations in TP53 gene were identified in approximately 5.7% (5/87 of this cohort of young women with breast

  1. (R-(+-α-Lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines

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    Kamarudin MNA

    2014-10-01

    Full Text Available Muhamad Noor Alfarizal Kamarudin, Nur Afiqah Mohd Raflee, Sharifah Salwa Syed Hussein, Jia Ye Lo, Hadi Supriady, Habsah Abdul KadirInstitute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, MalaysiaAbstract: Alpha-lipoic acid, a potent antioxidant with multifarious pharmacological benefits has been reported to be neuroprotective in several neuronal models and used to treat neurological disorders such as Alzheimer’s disease. Nonetheless, conclusive mechanisms of alpha-lipoic acid for its protective effects particularly in NG108-15 cells have never been investigated. In this study, the intricate neuroprotective molecular mechanisms by (R-(+-alpha-lipoic acid (R-LA against H2O2-induced cell death in an in vitro model of neurodegeneration were elucidated. Pretreatment with R-LA (2 hours significantly increased NG108-15 cell viability as compared to H2O2-treated cells and mitigated the induction of apoptosis as evidenced by Hoechst 33342/propidium iodide staining. R-LA (12.5–50 µM aggrandized the reduced glutathione over glutathione disulfide ratio followed by a reduction in the intracellular reactive oxygen species level and an increase in mitochondrial membrane potential following H2O2 exposure. Moreover, pretreatment with R-LA stimulated the activation of PI3K-Akt through mTORC1 and mTORC2 components (mTOR, rictor and raptor and production of antiinflammatory cytokine, IL-10 which led to the inactivation of glycogen synthase kinase-3β (GSK-3β and reduction of both Bax/Bcl2 and Bax/Bcl-xL ratios, accompanied by inhibition of the cleaved caspase-3. Additionally, this observation was preceded by the suppression of NF-κβ p65 translocation and production of proinflammatory cytokines (IL-6 and TNF-α. The current findings accentuate new mechanistic insight of R-LA against apoptogenic and brain inflammatory factors in a neuronal model. These results further advocate the therapeutic potential of R-LA for

  2. Effect of Modified Otago Exercises on Postural Balance, Fear of Falling, and Fall Risk in Older Fallers With Knee Osteoarthritis and Impaired Gait and Balance: A Secondary Analysis.

    Science.gov (United States)

    Mat, Sumaiyah; Ng, Chin Teck; Tan, Pey June; Ramli, Norlisah; Fadzli, Farhana; Rozalli, Faizatul Izza; Mazlan, Mazlina; Hill, Keith D; Tan, Maw Pin

    2018-03-01

    Osteoarthritis (OA) is considered an established risk factor for falls. Published studies evaluating secondary falls prevention strategies among individuals with OA are limited. To evaluate the effect of a personalized home-based exercise program to improve postural balance, fear of falling, and falls risk in older fallers with knee OA and gait and balance problems. Randomized controlled trial. University of Malaya Medical Centre. Fallers who had both radiological OA and a Timed Up and Go (TUG) score of over 13.5 seconds. Postural sway (composite sway) was quantified with the Modified Clinical Test of Sensory Interaction on Balance (mCTSIB) under 4 different sensory conditions: eyes open on firm surface, eyes closed on firm surface, eyes open on unstable foam surface, and eyes closed on unstable foam surface. Participants were asked to stand upright and to attempt to hold their position for 10 seconds for each test condition. The average reading for all conditions were calculated. Participants randomized to the intervention arm received a home-based modified Otago Exercise Program (OEP) as part of a multifactorial intervention, whereas control participants received general health advice and conventional treatment. This was a secondary subgroup analysis from an original randomized controlled trial, the Malaysian Falls Assessment and Intervention Trial (MyFAIT) (trial registration number: ISRCTN11674947). Posturography using a long force plate balance platform (Balancemaster, NeuroCom, USA), the Knee injury and Osteoarthritis Outcome Score (KOOS) and the short-form Falls Efficacy Scale-International (short FES-I) were assessed at baseline and 6 months. Results of 41 fallers with radiological evidence of OA and impaired TUG (intervention, 17; control, 24) were available for the final analysis. Between-group analysis revealed significant improvements in the Modified Clinical Test of Sensory Interaction on Balance (mCTSIB), Limits of Stability (LOS), and short FES

  3. Promoting effect of small molecules in cardiomyogenic and neurogenic differentiation of rat bone marrow-derived mesenchymal stem cells

    Directory of Open Access Journals (Sweden)

    Khanabdali R

    2015-12-01

    Full Text Available Ramin Khanabdali,1 Anbarieh Saadat,1 Maizatul Fazilah,1 Khairul Fidaa’ Khairul Bazli,1 Rida-e-Maria Qazi,2 Ramla Sana Khalid,2 Durriyyah Sharifah Hasan Adli,1 Soheil Zorofchian Moghadamtousi,1 Nadia Naeem,2 Irfan Khan,2 Asmat Salim,2 ShamsulAzlin Ahmad Shamsuddin,1 Gokula Mohan1 1Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia; 2Dr Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan Abstract: Small molecules, growth factors, and cytokines have been used to induce differentiation of stem cells into different lineages. Similarly, demethylating agents can trigger differentiation in adult stem cells. Here, we investigated the in vitro differentiation of rat bone marrow mesenchymal stem cells (MSCs into cardiomyocytes by a demethylating agent, zebularine, as well as neuronal-like cells by β-mercaptoethanol in a growth factor or cytokines-free media. Isolated bone marrow-derived MSCs cultured in Dulbecco’s Modified Eagle’s Medium exhibited a fibroblast-like morphology. These cells expressed positive markers for CD29, CD44, and CD117 and were negative for CD34 and CD45. After treatment with 1 µM zebularine for 24 hours, the MSCs formed myotube-like structures after 10 days in culture. Expression of cardiac-specific genes showed that treated MSCs expressed significantly higher levels of cardiac troponin-T, Nkx2.5, and GATA-4 compared with untreated cells. Immunocytochemical analysis showed that differentiated cells also expressed cardiac proteins, GATA-4, Nkx 2.5, and cardiac troponin-T. For neuronal differentiation, MSCs were treated with 1 and 10 mM β-mercaptoethanol overnight for 3 hours in complete and serum-free Dulbecco’s Modified Eagle’s Medium, respectively. Following overnight treatment, neuron-like cells with axonal and dendritic-like projections originating from the

  4. The Prevalence and Distribution of Spina Bifida in a Single Major Referral Center in Malaysia

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    Adibah Sahmat

    2017-11-01

    Full Text Available BackgroundThe aim of this study is to review the medical history of patients with spina bifida, encompassing both aperta and occulta types born between the years 2003 until 2016, spanning a 13-year time period. We assessed each patient and maternal parent information, details of the defects, and conditions associated with the primary defect. We also include information on patients’ ambulation and education level (where available.MethodsData from the Department of Patient Information University of Malaya Medical Centre (UMMC, Malaysia was captured from spina bifida patients (ICD10: Q05 spina bifida. Data involved patients referred to UMMC between 2003 and 2016 and/or born in UMMC within that particular time frame. We filtered and extracted the information according to the data of clinical examination, medical review, and social history provided in the medical records.ResultsA total of 86 patient records with spina bifida were analyzed. Spina bifida prevalence rate in this study ranged from 1.87 to 8.9 per 1,000 live births depending on weightage. We note that ethnicity was a factor whereby the highest numbers of spina bifida were from Malays (n = 36, 41.86%, followed by equal numbers of Chinese and Indians (n = 24, 27.91%. The highest number of diagnoses reported was myelomeningocele type-spina bifida (n = 39, 45.35%. The most common site of the spina bifida lesion was located at the lumbar region irrespective of aperta or occulta types (n = 23, 26.74%. Data on other associated phenotypes of spina bifida such as hydrocephalus and encephalocele was also captured at 37.21% (n = 32 and 1.16% (n = 1, respectively. In terms of mobility, 32.84% (n = 22/67 of patients between the ages 4 and 16 years old were found to be mobile. As many as 36.07% of patients ranging from 5 to 16 years of age (n = 22/61 received formal education ranging from preschool to secondary school.ConclusionThe prevalence of spina bifida in

  5. Cost utility, budget impact, and scenario analysis of racecadotril in addition to oral rehydration for acute diarrhea in children in Malaysia

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    Rautenberg TA

    2018-03-01

    Full Text Available Tamlyn Anne Rautenberg,1,2 Ute Zerwes,3 Way Seah Lee4 1IGES Institut GmbH, Berlin, Germany; 2Health Economics and HIV/AIDS Research Division (HEARD, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa; 3Assessment in Medicine GmbH, Lörrach, Germany; 4Department of Pediatrics, University Malaya, Kuala Lumpur, Malaysia Objective: To perform cost utility (CU and budget impact (BI analyses augmented by scenario analyses of critical model structure components to evaluate racecadotril as adjuvant to oral rehydration solution (ORS for children under 5 years with acute diarrhea in Malaysia.Methods: A CU model was adapted to evaluate racecadotril plus ORS vs ORS alone for acute diarrhea in children younger than 5 years from a Malaysian public payer’s perspective. A bespoke BI analysis was undertaken in addition to detailed scenario analyses with respect to critical model structure components.Results: According to the CU model, the intervention is less costly and more effective than comparator for the base case with a dominant incremental cost-effectiveness ratio of –RM 1,272,833/quality-adjusted life year (USD –312,726/quality-adjusted life year in favor of the intervention. According to the BI analysis (assuming an increase of 5% market share per year for racecadotril+ORS for 5 years, the total cumulative incremental percentage reduction in health care expenditure for diarrhea in children is 0.136578%, resulting in a total potential cumulative cost savings of –RM 73,193,603 (USD –17,983,595 over a 5-year period. Results hold true across a range of plausible scenarios focused on critical model components.Conclusion: Adjuvant racecadotril vs ORS alone is potentially cost-effective from a Malaysian public payer perspective subject to the assumptions and limitations of the model. BI analysis shows that this translates into potential cost savings for the Malaysian public health care system. Results hold true at evidence-based base

  6. Book Reviews

    Directory of Open Access Journals (Sweden)

    A. Teeuw

    1961-04-01

    Full Text Available - R.J. Mohr, Carl A. Schmitz, Historische probleme in Nordost-Neuguinea. Huon-Halbinsel. Franz Steiner Verlag GMBH. Wiesbaden. 1960. 425 Pp., 43 Abbildungen, 9 karten und 1 Faltkarte. Studien zur Kulturkunde 16. Band. - P.E. de Josselin de Jong, H.G. Quaritch Wales, Prehistory and religion in South-East Asia. Bernard Quaritch Ltd., London 1957. 175 pp. text, 24 figs., 2 plates. - H.J. de Graaf, K.G. Tregonning, Under chartered company rule (North Borneo 1881-1946. University of Malaya Press, Singapore, 1958. 222 pp. tekst, 3 ills., 2 krtn. - S. Kooyman, Karl Erik Larsson, Fijian Studies. Etnologiska Studier, 25. Göteborg, 1960. 147 pag., 65 ills. - A. Teeuw, Hans Kähler, Ethnographische und linguistische studien über die Orang darat, Orang akit, Orang laut und Orang utan im Riau-Archipel und auf den Inseln an der Ostküste von Sumatra. Veröffentlichungen des Seminars für Indonesische und Südseesprachen der Universität Hamburg. Band 2. Berlin 1960. VI + 294 pp. - A. Teeuw, Ali Haji Ahmad, Puisi Baharu Melayu (Zaman Permulaan. Disusun oleh: Ali Haji Ahmad. Siri Sastera DBP. Bil. 4. Dewan Bahasa dan Pustaka....Kuala Lumpur 1959. XV + 60 pp. - A. Teeuw, William Shakespeare, Romeo dan Julia, di-terjemahkan oleh Trisno Sumardjo. Oxford University Press, Kuala Lumpur 1960. X + 150 pp. - A. Teeuw, Chepu Kenchana. Antoloji cherita2 pendek dunia. Pengenalan dan anotasi oleh Derwent May. Kata pengantar oleh Asraf. Oxford University Press, Kuala Lumpur 1960. 196 pp. - A. Teeuw, Hasan bin Muhammad Ali, Musafir. Siri Sastera DBP Bil. 3....Kuala Lumpur 1959. 142 pp. - A. Teeuw, Asraf, Mekar dan Segar. Bunga rampai cherita-cherita pendek angkatan baru. Di-pileh dan di-bicharakan oleh Asraf. Oxford University Press, Kuala Lumpur 1959. XV + 157 pp. - A. Teeuw, Cherita pendek DBP. Siri Sastera DBP Bil. 2. Dewan Bahasa dan Pustaka...Kula Lumpur 1958. 180 pp. - B.A.L. Cranstone, S. Kooyman, The art of Lake Sentani. Museum of Primitive Art, New York

  7. Beyond Critical Congenital Heart Disease: Newborn Screening Using Pulse Oximetry for Neonatal Sepsis and Respiratory Diseases in a Middle-Income Country.

    Science.gov (United States)

    Jawin, Vida; Ang, Hak-Lee; Omar, Asma; Thong, Meow-Keong

    2015-01-01

    Studies on pulse oximetry screening for neonatal sepsis and respiratory disease in a middle-income country are lacking. Newborn screening for critical congenital heart disease (CCHD) using pulse oximetry is an effective and life-saving strategy in developed countries. While most studies have reported false-positive results during CCHD screening, they have not elaborated on the detected disease types. We studied the effectiveness and outcomes of pulse oximetry newborn screening for non-cardiac hypoxemic diseases such as neonatal sepsis, respiratory diseases, and CCHD in a middle-income country. In a pilot study performed at the University Malaya Medical Centre (UMMC), Malaysia, all apparently healthy term newborns, delivered at UMMC were screened pre-discharge using pulse oximetry. Echocardiography was performed for newborns that had positive screening results on two separate occasions, 1-h apart. Newborns with normal echocardiograms were evaluated and treated for other non-cardiac diseases. Fifteen of 5247 term newborns had positive screening results. The median age at screening was 20 h. Thirteen newborns (0.24%) had significant non-cardiac diseases: sepsis (n = 2) and respiratory diseases (n = 11) that required hospitalization and treatment. The remaining two newborns with normal antenatal ultrasonograms had positive screening test and confirmed to have CCHD. Another 18 newborns with negative screening test were later admitted for treatment of sepsis (n = 16) and penumonia (n = 2). All newborns were treated and alive at the end of the study. The sensitivity and specificity of pulse oximetry screening for non-cardiac diseases were 42% and 99.9% respectively, and 100% and 99.7% for CCHD, respectively. Routine pulse oximetry screening test was effective in identifying newborns with CCHD and other hypoxemia illnesses, which may led to potential life-threatening condition. This study showed that the expanded use of pulse oximetry has immediate implications for low

  8. MDRD vs. CKD-EPI in comparison to 51Chromium EDTA: a cross sectional study of Malaysian CKD cohort.

    Science.gov (United States)

    Jalalonmuhali, Maisarah; Lim, Soo Kun; Md Shah, Mohammad Nazri; Ng, Kok Peng

    2017-12-13

    Accurate measurement of renal function is important: however, radiolabelled gold standard measurement of GFR is highly expensive and can only be used on a very limited scale. We aim to compare the performance of Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equations in the multi-ethnic population attending University Malaya Medical Centre (UMMC). This is a cross-sectional study recruiting patients, who attend UMMC Nephrology clinics on voluntary basis. 51-Chromium EDTA ( 51 Cr-EDTA) plasma level was used to measure the reference GFR. The serum creatinine was determined by IDMS reference modified Jaffe kinetic assay (Cr Jaffe ). The predictive capabilities of MDRD and CKD-EPI based equations were calculated. Data was analysed using SPSS version 20 and correlation, bias, precision and accuracy were determined. A total of 113 subjects with mean age of 58.12 ± 14.76 years and BMI of 25.99 ± 4.29 kg/m 2 were recruited. The mean reference GFR was 66.98 ± 40.65 ml/min/1.73m 2 , while the estimated GFR based on MDRD and CKD-EPI formula were 62.17 ± 40.40, and 60.44 ± 34.59, respectively. Both MDRD and CKD-EPI were well-correlated with reference GFR (0.806 and 0.867 respectively) and statistically significant with p < 0.001. In the overall cohort, although MDRD had smaller bias than CKD-EPI (4.81 vs. 6.54), CKD-EPI was more precise (25.22 vs. 20.29) with higher accuracy within 30% of measured GFR (79.65 vs. 86.73%). The CKD-EPI equation appeared to be more precise and accurate than the MDRD equation in estimating GFR in our cohort of multi-ethnic populations in Malaysia.

  9. Nutritional Status of Breast Cancer Survivors 1 Year after Diagnosis: A Preliminary Analysis from the Malaysian Breast Cancer Survivorship Cohort Study.

    Science.gov (United States)

    Majid, Hazreen Abd; Keow, Low Phei; Islam, Tania; Su, Tin Tin; Cantwell, Marie; Taib, Nur Aishah

    2018-04-01

    Lifestyle factors, such as diet, body weight, and physical activity, are linked to better survival after breast cancer (BC) diagnosis. A high percentage of the Malaysian population is overweight or obese. In addition, studies have shown a disparity in survival among Malaysian women compared with other higher-income countries. The Malaysian Breast Cancer Survivorship Cohort (MyBCC) study aims to study lifestyle factors that affect survival in BC survivors. These are the preliminary findings on the nutritional status of Malaysian BC survivors. Our aim was to evaluate the nutritional status of BC survivors at 1 year after diagnosis. This was a cross-sectional study of 194 participants from the MyBCC study, recruited within 1 year of their diagnosis. Participants completed a 3-day food diary. Malaysian women (aged 18 years and older) who were newly diagnosed with primary BC, managed at the University Malaya Medical Center, and able to converse either in Malay, English, or Mandarin were included. Dietary intake and prevalence of overweight or obesity among participants 1 year after diagnosis were measured. Student's t test and analysis of variance or its equivalent nonparametric test were used for association in continuous variables. About 66% (n=129) of participants were overweight or obese and >45% (n=86) had high body fat percentage 1 year after diagnosis. The participants' diets were low in fiber (median=8.7 g/day; interquartile range=7.2 g/day) and calcium (median=458 mg/day; interquartile range=252 mg/day). Ethnicity and educational attainment contributed to the differences in dietary intake among participants. Higher saturated fat and lower fiber intake were observed among Malay participants compared with other ethnic groups. Overweight and obesity were highly prevalent among BC survivors and suboptimal dietary intake was observed. Provision of an individualized medical nutrition therapy by a qualified dietitian is crucial as part of comprehensive BC survivorship

  10. Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers

    Directory of Open Access Journals (Sweden)

    Albaayit SFA

    2016-06-01

    Full Text Available Shaymaa Fadhel Abbas Albaayit,1,2 Yusuf Abba,3 Rasedee Abdullah,4 Noorlidah Abdullah1 1Faculty of Science, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia; 2Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq; 3Department of Veterinary Pathology and Microbiology, 4Department of Veterinary Laboratory Diagnosis, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia Abstract: Clausena excavata is a natural herb with both antioxidant and anti-inflammatory properties. It has been used for decades in folkloric practice for the amelioration of various ailments. In this study, the gastroprotective activity of methanolic extract of C. excavata leaves (MECE was determined in the Sprague Dawley rat ethanol-induced gastric ulcer model. Rats were pretreated with a single dose of vehicle (5% Tween 20, 20 mg/mL omeprazole, 400 and 200 mg/mL of MECE dissolved in 5% Tween 20. Ulcer was induced with 5 mL/kg of ethanol and stomach tissue was obtained after 1 hour. Histological examination was done on hematoxylin and eosin, periodic acid-Schiff, and immunochemically stained gastric mucosal tissues. Prostaglandin E2, superoxide dismutase, catalase, glutathione peroxidase, and lipid peroxidation levels of the gastric tissue homogenates were also determined. Significantly (P<0.05 smaller ulcer areas, less intense edema, and fewer leukocytes’ infiltration were observed in MECE- and omeprazole-treated than in untreated gastric mucosa with ulcer. The gastric pH, mucus production, superoxide dismutase, catalase, and glutathione peroxidase contents increased, while the lipid peroxidation content decreased as a result of MECE treatment. Bcl-2-associated X protein was underexpressed, while heat shock protein 70 and transforming growth factor-beta protein were overexpressed in the ulcerated gastric mucosa tissues treated with omeprazole and MECE. Similarly, there was a reduction in

  11. Elder mistreatment in a community dwelling population: the Malaysian Elder Mistreatment Project (MAESTRO) cohort study protocol.

    Science.gov (United States)

    Choo, Wan Yuen; Hairi, Noran Naqiah; Sooryanarayana, Rajini; Yunus, Raudah Mohd; Hairi, Farizah Mohd; Ismail, Norliana; Kandiben, Shathanapriya; Mohd Ali, Zainudin; Ahmad, Sharifah Nor; Abdul Razak, Inayah; Othman, Sajaratulnisah; Tan, Maw Pin; Mydin, Fadzilah Hanum Mohd; Peramalah, Devi; Brownell, Patricia; Bulgiba, Awang

    2016-05-25

    Despite being now recognised as a global health concern, there is still an inadequate amount of research into elder mistreatment, especially in low and middle-income regions. The purpose of this paper is to report on the design and methodology of a population-based cohort study on elder mistreatment among the older Malaysian population. The study aims at gathering data and evidence to estimate the prevalence and incidence of elder mistreatment, identify its individual, familial and social determinants, and quantify its health consequences. This is a community-based prospective cohort study using randomly selected households from the national census. A multistage sampling method was employed to obtain a total of 2496 older adults living in the rural Kuala Pilah district. The study is divided into two phases: cross-sectional study (baseline), and a longitudinal follow-up study at the third and fifth years. Elder mistreatment was measured using instrument derived from the previous literature and modified Conflict Tactic Scales. Outcomes of elder mistreatment include mortality, physical function, mental health, quality of life and health utilisation. Logistic regression models are used to examine the relationship between risk factors and abuse estimates. Cox proportional hazard regression will be used to estimate risk of mortality associated with abuse. Associated annual rate of hospitalisation and health visit frequency, and reporting of abuse, will be estimated using Poisson regression. The study has been approved by the Medical Ethics Committee of the University of Malaya Medical Center (MEC Ref 902.2) and the Malaysian National Medical Research Register (NMRR-12-1444-11726). Written consent was obtained from all respondents prior to baseline assessment and subsequent follow-up. Findings will be disseminated to local stakeholders via forums with community leaders, and health and social welfare departments, and published in appropriate scientific journals and

  12. Prevalence and associated factors of contraceptive discontinuation and switching among Bangladeshi married women of reproductive age

    Directory of Open Access Journals (Sweden)

    Mahumud RA

    2015-01-01

    Full Text Available Rashidul Alam Mahumud,1 Md Golam Hossain,2 Abdur Razzaque Sarkar,1 Md Nurul Islam,2 Md Ripter Hossain,2 Aik Saw,3 Jahangir AM Khan1,4 1Health Economics and Financing Research Group, Center for Equity and Health Systems, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; 2Department of Statistics, University of Rajshahi, Rajshahi, Bangladesh; 3Department of Orthopaedic Surgery, National Orthopaedic Centre of Excellence for Research and Learning, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 4Adjunct Faculty, Health Economics Unit, Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden Introduction: Contraceptive discontinuation is a worldwide incident that may be connected with low incentive to avoid pregnancy. Contraceptive discontinuation highly contributes to unplanned pregnancy and unwanted births.Objectives: The objective of this study was to observe the prevalence of discontinuation and switching of contraceptive methods among Bangladeshi married women. In addition, the sociodemographic factors associated with contraceptive discontinuation and switching were assessed.Methods: Secondary cross-sectional data was used in this study. A total of 16,273 married Bangladeshi women of reproductive age (15–49 years were considered in the present study, from the Bangladesh Demographic and Health Survey, 2011. Logistic regression models were used to determine the relationships between key sociodemographic factors and user status.Results: The prevalence of discontinuation and switching of contraceptive method among women were 38.4% and 15.4%, respectively. The logistic regression model demonstrated that women in early reproductive years (25–29 years and 30–34 years significantly more often (odds ratio [OR] =0.84 and 0.71, respectively discontinued use of contraceptives. Significantly higher rates of discontinuation were pronounced among women who

  13. In vivo antitumor and antimetastatic effects of flavokawain B in 4T1 breast cancer cell-challenged mice

    Directory of Open Access Journals (Sweden)

    Abu N

    2015-03-01

    Full Text Available Nadiah Abu,1,2 Nurul Elyani Mohamed,2 Swee Keong Yeap,3 Kian Lam Lim,4 M Nadeem Akhtar,5 Aimi Jamil Zulfadli,3 Beh Boon Kee,2 Mohd Puad Abdullah,2 Abdul Rahman Omar,3 Noorjahan Banu Alitheen2 1Bright Sparks Unit, Universiti Malaya, Kuala Lumpur, Malaysia; 2Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, 3Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor Darul Ehsan, Malaysia; 4Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Lot PT, Jalan Sungai Long, Bandar Sungai Long, Cheras, Selangor, Malaysia; 5Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, Kuantan Pahang, Malaysia Abstract: Flavokawain B (FKB is a naturally occurring chalcone that can be isolated through the root extracts of the kava-kava plant (Piper methysticum. It can also be synthesized chemically to increase the yield. This compound is a promising candidate as a biological agent, as it is reported to be involved in a wide range of biological activities. Furthermore, FKB was reported to have antitumorigenic effects in several cancer cell lines in vitro. However, the in vivo antitumor effects of FKB have not been reported on yet. Breast cancer is one of the major causes of cancer-related deaths in the world today. Any potential treatment should not only impede the growth of the tumor, but also modulate the immune system efficiently and inhibit the formation of secondary tumors. As presented in our study, FKB induced apoptosis in 4T1 tumors in vivo, as evidenced by the terminal deoxynucleotidyl transferase dUTP nick end labeling and hematoxylin and eosin staining of the tumor. FKB also regulated the immune system by increasing both helper and cytolytic T-cell and natural killer cell populations. In addition, FKB also enhanced the levels of interleukin 2 and interferon gamma but suppressed interleukin 1B. Apart from that, FKB was also found to inhibit

  14. Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells

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    Etti IC

    2017-03-01

    Full Text Available Imaobong Christopher Etti,1,2 Abdullah Rasedee,3 Najihah Mohd Hashim,4 Ahmad Bustamam Abdul,5 Arifah Kadir,6 Swee Keong Yeap,7 Peter Waziri,5 Ibrahim Malami,5 Kian Lam Lim,8 Christopher J Etti9 1Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Malaysia; 2Department of Pharmacology and Toxicology, University of Uyo, Uyo, Nigeria; 3Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Malaysia; 4Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 5MAKNA-Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia; 6Department of Veterinary Preclinical Science, Universiti Putra Malaysia, Serdang, Malaysia; 7Laboratory of Vaccine and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia; 8Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Cheras, Selangor, Malaysia; 9Department of Agricultural and Food Engineering, University of Uyo, Uyo, Nigeria Abstract: Artonin E is a prenylated flavonoid compound isolated from the stem bark of Artocarpus elasticus. This phytochemical has been previously reported to be drug-like with full compliance to Lipinski’s rule of five and good physicochemical properties when compared with 95% of orally available drugs. It has also been shown to possess unique medicinal properties that can be utilized in view of alleviating most human disease conditions. In this study, we investigated the cytotoxic mechanism of Artonin E in MCF-7 breast cancer cells, which has so far not been reported. In this context, Artonin E significantly suppressed the breast cancer cell’s viability while inducing apoptosis in a dose-dependent manner. This apoptosis induction was caspase dependent, and it is mediated mainly through the intrinsic pathway with the elevation of total reactive oxygen species

  15. Methods to improve rehabilitation of patients following breast cancer surgery: a review of systematic reviews

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    Loh SY

    2015-03-01

    Full Text Available Siew Yim Loh, Aisya Nadia Musa Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Context: Breast cancer is the most prevalent cancer amongst women but it has the highest survival rates amongst all cancer. Rehabilitation therapy of post-treatment effects from cancer and its treatment is needed to improve functioning and quality of life. This review investigated the range of methods for improving physical, psychosocial, occupational, and social wellbeing in women with breast cancer after receiving breast cancer surgery. Method: A search for articles published in English between the years 2009 and 2014 was carried out using The Cochrane Database of Systematic Reviews, the Database of Abstracts of Reviews of Effects, PubMed, and ScienceDirect. Search terms included: ‘breast cancer’, ‘breast carcinoma’, ‘surgery’, ‘mastectomy’, ‘lumpectomy’, ‘breast conservation’, ‘axillary lymph node dissection’, ‘rehabilitation’, 'therapy’, ‘physiotherapy’, ‘occupational therapy’, ‘psychological’, ‘psychosocial’, ‘psychotherapy’, ‘exercise’, ‘physical activity’, ‘cognitive’, ‘occupational’, ‘alternative’, ‘complementary’, and ‘systematic review’. Study selection: Systematic reviews on the effectiveness of rehabilitation methods in improving post-operative physical, and psychological outcomes for breast cancer were selected. Sixteen articles met all the eligibility criteria and were included in the review. Data extraction: Included review year, study aim, total number of participants included, and results. Data synthesis: Evidence for exercise rehabilitation is predominantly in the improvement of shoulder mobility and limb strength. Inconclusive results exist for a range of rehabilitation methods (physical, psycho-education, nutritional, alternative-complementary methods for addressing the domains of psychosocial, cognitive, and

  16. Dopant concentration and thermoluminescence (TL) properties of tailor-made Ge-doped SiO2 fibres

    International Nuclear Information System (INIS)

    Zahaimi, Nurul Arina; Ooi Abdullah, Mohd Haris Ridzuan; Zin, Hafiz; Abdul Rahman, Ahmad Lutfi; Hashim, Suhairul; Saripan, Mohd Iqbal; Paul, Mukul Chandra; Bradley, D.A.; Abdul Rahman, Ahmad Taufek

    2014-01-01

    Study focuses on characterisation of diverse concentrations of Ge-doped SiO 2 fibre as a potential thermoluminescence (TL) system for radiotherapy dosimetry. Irradiations were made using a linear accelerator providing 6 MV and 10 MV photon beams. Investigation has been done on various doped core diameter Ge-doped SiO 2 glass fibres such as commercial telecommunication fibres of 8 µm and 9 µm (CorActive High Tech, Canada), tailor-made fibres of 23 and 50 µm produced by the Central Glass and Ceramic Research Institute Kolkata, and tailor-made fibres of 11 µm produced by the University of Malaya Photonics Research Centre. The fibres have been characterised for TL sensitivity, reproducibility, dose- and energy-dependence. The area under the TL glow curve increases with increasing core diameter. For repeat irradiations at a fixed dose the dosimeter produces a flat response better than 4% (1SD) of the mean of the TL distribution. Minimal TL signal fading was found, less than 0.5% per day post irradiation. Linearity of TL has been observed with a correlation coefficient (r 2 ) of better than 0.980 (at 95% confidence level). For particular dopant concentrations, the least square fits show the change in TL yield, in counts per second per unit mass, obtained from 50 µm core diameter fibres irradiated at 6 MV of photon to be 8 times greater than that of 8 µm core diameter fibre. With respect to energy response, the TL yield at 10 MV decreases by∼5% compared to that at 6 MV, primarily due to the lower mass energy absorption coefficient at higher photon energy. These early results indicate that selectively screened fibres can be developed into a promising TL system, offering high spatial resolution capability and, with this, verification of complex radiotherapy dose distributions. - Highlights: • We examined the TL glow curve intensity for various diameter sizes of germanium doped silica glass fibre. • TL sensitivity increased with the increase of fibre core

  17. Chronic care model in primary care: can it improve health-related quality of life?

    Directory of Open Access Journals (Sweden)

    Aryani FMY

    2016-01-01

    Full Text Available Faridah Md Yusof Aryani,1 Shaun Wen Huey Lee,2 Siew Siang Chua,3 Li Ching Kok,4 Benny Efendie,2 Thomas Paraidathathu5 1Pharmaceutical Services Division, Ministry of Health Malaysia, Petaling Jaya, 2School of Pharmacy, Monash University Malaysia, Bandar Sunway, 3Department of Pharmacy, Faculty of Medicine, University of Malaya, 4Clinical Research Centre, Kuala Lumpur Hospital, Kuala Lumpur, 5School of Pharmacy, Taylor’s University, Subang Jaya, Selangor, Malaysia Purpose: Chronic diseases such as hypertension, diabetes mellitus, and hyperlipidemia are public health concerns. However, little is known about how these affect patient-level health measures. The aim of the study was to examine the impact of a chronic care model (CCM on the participant’s health-related quality of life (QoL. Patients and methods: Participants received either usual care or CCM by a team of health care professionals including pharmacists, nurses, dietitians, and general practitioners. The participants in the intervention group received medication counseling, adherence, and dietary advice from the health care team. The QoL was measured using the EQ-5D (EuroQoL-five dimension, health-related quality of life questionnaire and comparison was made between usual care and intervention groups at the beginning and end of the study at 6 months. Results: Mean (standard deviation EQ-5D index scores improved significantly in the intervention group (0.92±0.10 vs 0.95±0.08; P≤0.01, but not in the usual care group (0.94±0.09 vs 0.95±0.09; P=0.084. Similarly, more participants in the intervention group reported improvements in their QoL compared with the usual care group, especially in the pain/discomfort and anxiety/depression dimensions. Conclusion: The implementation of the CCM resulted in significant improvement in QoL. An interdisciplinary team CCM approach should be encouraged, to ultimately result in behavior changes and improve the QoL of the patients. Keywords: diabetes

  18. The Prevalence and Distribution of Spina Bifida in a Single Major Referral Center in Malaysia.

    Science.gov (United States)

    Sahmat, Adibah; Gunasekaran, Renuka; Mohd-Zin, Siti W; Balachandran, Lohis; Thong, Meow-Keong; Engkasan, Julia P; Ganesan, Dharmendra; Omar, Zaliha; Azizi, Abu Bakar; Ahmad-Annuar, Azlina; Abdul-Aziz, Noraishah M

    2017-01-01

    The aim of this study is to review the medical history of patients with spina bifida, encompassing both aperta and occulta types born between the years 2003 until 2016, spanning a 13-year time period. We assessed each patient and maternal parent information, details of the defects, and conditions associated with the primary defect. We also include information on patients' ambulation and education level (where available). Data from the Department of Patient Information University of Malaya Medical Centre (UMMC), Malaysia was captured from spina bifida patients (ICD10: Q05 spina bifida). Data involved patients referred to UMMC between 2003 and 2016 and/or born in UMMC within that particular time frame. We filtered and extracted the information according to the data of clinical examination, medical review, and social history provided in the medical records. A total of 86 patient records with spina bifida were analyzed. Spina bifida prevalence rate in this study ranged from 1.87 to 8.9 per 1,000 live births depending on weightage. We note that ethnicity was a factor whereby the highest numbers of spina bifida were from Malays ( n  = 36, 41.86%), followed by equal numbers of Chinese and Indians ( n  = 24, 27.91%). The highest number of diagnoses reported was myelomeningocele type-spina bifida ( n  = 39, 45.35%). The most common site of the spina bifida lesion was located at the lumbar region irrespective of aperta or occulta types ( n  = 23, 26.74%). Data on other associated phenotypes of spina bifida such as hydrocephalus and encephalocele was also captured at 37.21% ( n  = 32) and 1.16% ( n  = 1), respectively. In terms of mobility, 32.84% ( n  = 22/67) of patients between the ages 4 and 16 years old were found to be mobile. As many as 36.07% of patients ranging from 5 to 16 years of age ( n  = 22/61) received formal education ranging from preschool to secondary school. The prevalence of spina bifida in UMMC is as according to

  19. The Prevalence of Anti-Aquaporin 4 Antibody in Patients with Idiopathic Inflammatory Demyelinating Diseases Presented to a Tertiary Hospital in Malaysia: Presentation and Prognosis

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    S. Abdullah

    2017-01-01

    Full Text Available Background. There have been inconsistent reports on the prevalence and pathogenicity of anti-Aquaporin 4 (AQP4 in patients presented with idiopathic inflammatory demyelinating diseases (IIDDs. Objective. To estimate the prevalence of anti-AQP4 antibody in patients with IIDDs presented to University Malaya Medical Centre in terms of patients’ clinical and radiological presentations and prognoses. Methods. Retrospective data review of IIDDs patients presented from 2005 to 2015. Patients were classified into classical multiple sclerosis (CMS, opticospinal (OS presentation, optic neuritis (ON, transverse myelitis (TM, brainstem syndrome (BS, and tumefactive MS. Anti-Aquaporin 4 antibody was tested using the Indirect Immunofluorescence Test (IIFT cell-based assay. Statistical analysis was done using the SPSS version 20. Results. Anti-AQP4 antibody was detected in 53% of patients presented with IIDDs. CMS was more common in the seronegative group, 27/47 (57.45%; p<0.001. Conversely, OS involvement was more common in the seropositive group, 26/53 (49.06%; p<0.001. Longitudinally extensive spinal cord lesions (LESCLs on MRI were also more common in the seropositive group, 29/40 (72.50%; p=0.004. Only 2/40 (5.00% had MRI evidence of patchy or multiple short-segment spinal cord lesions in the AQP4-positive group (p=0.003. The relapse rate and Expanded Disability Status Scale (EDSS were also higher in the seropositive group (5.43 versus 3.17, p=0.005; 4.07 versus 2.51, p=0.006, resp.. Typical clinical presentations that defined NMO were also seen in the seronegative patients, but in a lower frequency. Conclusion. Our cohort of patients had a higher prevalence of seropositivity of anti-AQP4 antibody as compared to those in Western countries. This was also associated with a more typical presentation of opticospinal involvement with LESCLs on MRI, a higher rate of relapse, and EDSS.

  20. Prevalence of serum celiac antibodies in a multiracial Asian population--a first study in the young Asian adult population of Malaysia.

    Science.gov (United States)

    Yap, Theresa Wan-Chen; Chan, Weng-Kai; Leow, Alex Hwong-Ruey; Azmi, Ahmad Najib; Loke, Mun-Fai; Vadivelu, Jamuna; Goh, Khean-Lee

    2015-01-01

    Celiac disease (CD) is an immune-mediated disorder induced by the ingestion of gluten in genetically susceptible persons. The prevalence of CD in Malaysia is unknown. We aim to determine the seroprevalence of CD antibodies and also investigate the correlation between H. pylori infection and CD in the young and healthy multiracial Malaysian population. Healthy young adult volunteers between the ages of 18-30 years were consecutively recruited from June 2012 to May 2014 at the University of Malaya Medical Centre (UMMC), Kuala Lumpur. Serum samples from all the participants were tested for anti-gliadin antibody immunoglobulin A/immunoglobulin G (IgA/IgG) and anti-tissue transglutaminase antibody (tTG) IgA/IgG. Samples positive for both anti-gliadin and anti-tTG were further validated for anti-human endomysial IgA antibodies (EmA). Serological diagnosis of CD was made when anti-gliadin, anti-tTG and anti-EmA were positive. 562 qualified participants with mean age 24 ± 2.4 years old were recruited into our study. CD was found in 7 participants where most of them were asymptomatic and unaware of their CD status. The median of anti-gliadin and anti-tTG IgA/IgG value was 38.2 U/ml (interquartile range, 28.3-60.4 U/ml) and 49.2 U/ml (interquartile range, 41.1-65.9 U/ml), respectively. Seroprevalence of CD antibodies was 1.9% (6 out of 324) in female while only 0.4% (1 out of 238) in male. Seroprevalence among Malay was 0.8% (2 of 236), Chinese was 1.7% (3 of 177) and Indian was 1.3% (2 of 149). Overall, seroprevalence of CD antibodies in healthy asymptomatic adults in the Malaysian population was 1.25% (95% CI, 0.78%-1.72%). No significant relationship was discovered between CD and H. pylori infection. The seroprevalence of CD antibodies in healthy young adults in the Malaysian population was 1.25% (1 in 100). CD is underdiagnosed and it could be a much greater problem in Malaysia than previously thought.

  1. Prevalence of Serum Celiac Antibodies in a Multiracial Asian Population-A First Study in the Young Asian Adult Population of Malaysia

    Science.gov (United States)

    Yap, Theresa Wan-Chen; Chan, Weng-Kai; Leow, Alex Hwong-Ruey; Azmi, Ahmad Najib; Loke, Mun-Fai; Vadivelu, Jamuna; Goh, Khean-Lee

    2015-01-01

    Background Celiac disease (CD) is an immune-mediated disorder induced by the ingestion of gluten in genetically susceptible persons. The prevalence of CD in Malaysia is unknown. We aim to determine the seroprevalence of CD antibodies and also investigate the correlation between H. pylori infection and CD in the young and healthy multiracial Malaysian population. Methods Healthy young adult volunteers between the ages of 18–30 years were consecutively recruited from June 2012 to May 2014 at the University of Malaya Medical Centre (UMMC), Kuala Lumpur. Serum samples from all the participants were tested for anti-gliadin antibody immunoglobulin A/immunoglobulin G (IgA/IgG) and anti-tissue transglutaminase antibody (tTG) IgA/IgG. Samples positive for both anti-gliadin and anti-tTG were further validated for anti-human endomysial IgA antibodies (EmA). Serological diagnosis of CD was made when anti-gliadin, anti-tTG and anti-EmA were positive. Results 562 qualified participants with mean age 24 ± 2.4 years old were recruited into our study. CD was found in 7 participants where most of them were asymptomatic and unaware of their CD status. The median of anti-gliadin and anti-tTG IgA/IgG value was 38.2 U/ml (interquartile range, 28.3–60.4 U/ml) and 49.2 U/ml (interquartile range, 41.1–65.9 U/ml), respectively. Seroprevalence of CD antibodies was 1.9% (6 out of 324) in female while only 0.4% (1 out of 238) in male. Seroprevalence among Malay was 0.8% (2 of 236), Chinese was 1.7% (3 of 177) and Indian was 1.3% (2 of 149). Overall, seroprevalence of CD antibodies in healthy asymptomatic adults in the Malaysian population was 1.25% (95% CI, 0.78%-1.72%). No significant relationship was discovered between CD and H. pylori infection. Conclusions The seroprevalence of CD antibodies in healthy young adults in the Malaysian population was 1.25% (1 in 100). CD is underdiagnosed and it could be a much greater problem in Malaysia than previously thought. PMID:25799401

  2. Sedih sampai buta : Blindness, modernity and tradition in Malay films of the 1950s and 1960s

    Directory of Open Access Journals (Sweden)

    Timothy P. Barnard

    2005-01-01

    Full Text Available In the 1950s and 1960s Malaya/Malaysia was undergoing a tremendous amount of social change. One method of examining how this period was understood is through Malay film. A number of Malay writers and activists found work in the vibrant film industry of the Peninsula, which was centred on Singapore at the time, and proceeded to infuse many of the films with their ideas, hopes, and understandings of the society they saw around them. As part of these developments, and perhaps due to the phenomenon of repetition, blindness became a metaphor in a number of films to address the issue of modernity and tradition, and the tension between rural and urban. In films produced in the early 1950s blindness occurs among kampung-based characters, or among supporting players within the larger drama. Their blindness is usually caused or compounded by a sadness in their lives. In these films, an urban-based character attempts to arrange for an operation that will remedy the condition, but only after a character has had to deal with the underside of modernity. The use of blindness as a trope for moral/ethical failure is alien to traditional Malay culture. Thus, its use and repetition represent the external influences and ideas of modernity in Malay filmmaking of the period. While the city was frightening, it held the possibility of change for the better. Characters in these films had to deal first with the negative sides of such a life, but if they retained the positive traditional values of Malay culture, all would be well. By the early 1960s, however, after the promise of independence had transitioned to debates over merger, identity, and economic and social disruption, the metaphor of blindness had also shifted. Although technologycould cure the condition, the world that accompanied this technology was one that was unbearable. Unlike the earlier supporting characters facing a sightless life, it was now the main character who becomes blind in a manner that is

  3. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2002-07-01

    , Colorado: Westview, 2000, xvi + 296 pp. -Robert W. Hefner, Leo Howe, Hinduism and hierarchy in Bali. Oxford: James Currey, Santa Fe: School of American Research Press, 2001, xviii + 228 pp. -Russell Jones, Margaret Shennan, Out in the midday sun; The British in Malaya, 1880-1960. London: John Murray, 2000, xviii + 426 pp. -Russell Jones, T.N. Harper, The end of empire and the making of Malaya. Cambridge: Cambridge University Press, 1999, xviii + 417 pp. -Sirtjo Koolhof, Christian Pelras, The Bugis. Oxford: Blackwell, 1996, xvii + 386 pp. [The People of South-East Asia and the Pacific.] -Tania Li, Lily Zubaidah Rahim, The Singapore dilemma; The political and educational marginality of the Malay community. Kuala Lumpur: Oxford University Press, 1998, xviii + 302 pp. -Yasser Mattar, Vincent J.H. Houben ,Coolie labour in colonial Indonesia; A study of labour relations in the Outer Islands, c. 1900-1940. Wiesbaden: Harrassowitz, 1999, xvi + 268 pp., J. Thomas Lindblad et al. (eds -Yasser Mattar, Zawawi Ibrahim, The Malay labourer; By the window of capitalism. Singapore: Institute of Southeast Asian Studies, 1998, xvi + 348 PP. -Kees Mesman Schultz, Leo J.T. van der Kamp, C.L.M. Penders, The West Guinea debacle; Dutch decolonisation and Indonesia 1945-1962. Leiden: KITLV Press, 2002, viii + 490 pp. -S. Morshidi, Beng-Lan Goh, Modern dreams; An inquiry into power, cultural production, and the cityscape in contemporary urban Penang, Malaysia. Ithaca, New York: Cornell University Southeast Asia Program, 2002, 224 pp. [Studies on Southeast Asia 31.] -Richard Scaglion, Gert-Jan Bartstra, Bird's Head approaches; Irian Jaya studies - a programme for interdisciplinary research. Rotterdam: Balkema, 1998, ix + 275 pp. [Modern Quarternary Research in Southeast Asia 15.] -Simon C. Smith, R.S. Milne ,Malaysian politics under Mahathir. London: Routledge, 1999, xix + 225 pp., Diane K. Mauzy (eds -Reed L. Wadley, Christine Helliwell, 'Never stand alone'; A study of Borneo sociality. Phillips

  4. Genotypic and Phenotypic Detection of AmpC β-lactamases in Enterobacter spp. Isolated from a Teaching Hospital in Malaysia.

    Science.gov (United States)

    Mohd Khari, Fatin Izzati; Karunakaran, Rina; Rosli, Roshalina; Tee Tay, Sun

    2016-01-01

    The objective of this study was to determine the occurrence of chromosomal and plasmid-mediated β-lactamases (AmpC) genes in a collection of Malaysian isolates of Enterobacter species. Several phenotypic tests for detection of AmpC production of Enterobacter spp. were evaluated and the agreements between tests were determined. Antimicrobial susceptibility profiles for 117 Enterobacter clinical isolates obtained from the Medical Microbiology Diagnostic Laboratory, University Malaya Medical Centre, Malaysia, from November 2012-February 2014 were determined in accordance to CLSI guidelines. AmpC genes were detected using a multiplex PCR assay targeting the MIR/ACT gene (closely related to chromosomal EBC family gene) and other plasmid-mediated genes, including DHA, MOX, CMY, ACC, and FOX. The AmpC β-lactamase production of the isolates was assessed using cefoxitin disk screening test, D69C AmpC detection set, cefoxitin-cloxacillin double disk synergy test (CC-DDS) and AmpC induction test. Among the Enterobacter isolates in this study, 39.3% were resistant to cefotaxime and ceftriaxone and 23.9% were resistant to ceftazidime. Ten (8.5%) of the isolates were resistant to cefepime, and one isolate was resistant to meropenem. Chromosomal EBC family gene was amplified from 36 (47.4%) E. cloacae and three (25%) E. asburiae. A novel blaDHA type plasmid-mediated AmpC gene was identified for the first time from an E. cloacae isolate. AmpC β-lactamase production was detected in 99 (89.2%) of 111 potential AmpC β-lactamase producers (positive in cefoxitin disk screening) using D69C AmpC detection set. The detection rates were lower with CC-DDS (80.2%) and AmpC induction tests (50.5%). There was low agreement between the D69C AmpC detection set and the other two phenotypic tests. Of the 40 isolates with AmpC genes detected in this study, 87.5%, 77.5% and 50.0% of these isolates were positive by the D69C AmpC detection set, CC-DDS and AmpC induction tests, respectively

  5. Time for a new language for asthma control: results from REALISE Asia

    Directory of Open Access Journals (Sweden)

    Price D

    2015-09-01

    Full Text Available David Price,1,2 Aileen David-Wang,3 Sang-Heon Cho,4 James Chung-Man Ho,5 Jae-Won Jeong,6 Chong-Kin Liam,7 Jiangtao Lin,8 Abdul Razak Muttalif,9 Diahn-Warng Perng,10,11 Tze-Lee Tan,12 Faisal Yunus,13 Glenn Neira14 On behalf of the REcognise Asthma and LInk to Symptoms and Experience (REALISE Asia Working Group 1Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK; 2Research in Real Life, Singapore; 3University of the Philippines-Philippine General Hospital, Manila, Philippines; 4College of Medicine, Seoul National University, Seoul, Republic of Korea; 5Department of Medicine, University of Hong Kong, Hong Kong, Special Administrative Region of the People's Republic of China; 6College of Medicine, Inje University, Goyang, Republic of Korea; 7Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 8China-Japan Friendship Hospital, Beijing, People's Republic of China; 9Institute of Respiratory Medicine, Kuala Lumpur, Malaysia; 10School of Medicine, National Yang-Ming University, 11Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; 12National University Hospital, Singapore; 13Persahabatan Hospital, University of Indonesia, Jakarta, Indonesia; 14Medical Affairs Department, Mundipharma Pte Ltd, Singapore Purpose: Asthma is a global health problem, and asthma prevalence in Asia is increasing. The REcognise Asthma and LInk to Symptoms and Experience Asia study assessed patients' perception of asthma control and attitudes toward treatment in an accessible, real-life adult Asian population. Patients and methods: An online survey of 2,467 patients with asthma from eight Asian countries/regions, aged 18–50 years, showed greater than or equal to two prescriptions in previous 2 years and access to social media. Patients were asked about their asthma symptoms, exacerbations and treatment type, views and perceptions of asthma control, attitudes toward asthma management, and

  6. Kazakhstan-Japan joint study on health effects of radiation in residents in and around former Semipalatinsk Nuclear Test Site

    International Nuclear Information System (INIS)

    Toshiaki Ogiu; Yoshiro Aoki; Sadayoshi Kobayashi; Shizuyo Kusumi; Jiro Inaba; Kenzhina, G.; Berezin, S.; Zhotabaev, Zh.; Berezina, M.; Sekerbayev, A.; Lukashenko, S.

    2008-01-01

    Full text: The National Nuclear Center of the Republic of Kazakhstan (NNC RK) and the Radiation Effects Association (REA, Japan) are now jointly carrying out 'Study on Health Effects of Radiation in Residents in and around the Former Semipalatinsk Nuclear Test Site (STS)' commissioned by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japanese Government. This joint study between Kazakhstan and Japan was initiated in 2001 in response to the request from the government of the Republic of Kazakhstan and to the resolution of the 53rd United Nations General Assembly in 1998 for providing the Kazakhstan with medical, environmental, economical and humanitarian assistance to the residents in and around Semipalatinsk Test Site. The purpose of the study is to obtain scientific evidence on the health effects of chronic and repeated long-term exposure to low level mixed (external and internal) radiation in residents in and around Semipalatinsk Test Site, and thereby to provide fundamental scientific information on the nature and extent of health effects that might have been incurred by such exposures. The mode of this type of exposure (chronic long-term mixed radiation) is conceivable in the current situation of exposure such as occupational exposure, but different from those of Hiroshima and Nagasaki in Japan where the exposure was mainly acute and external. In this study, exposed populations are consisting of residents of Dolon, Znamenka, Karaul, and Kainar (Semipalatinsk population - 1) and that of Southern Beskaragai Region including Mostik, Cheremushki, Bol'shaya Vladimirovka, Malaya Vladimirovka, Budene, Semenovka, etc. (Semipalatinsk population - 2). Control populations are consisting of residents of Kenzhekol, Kenes and Zhanaaul (Pavlodar Population - 1) and that of Kachiry, Irtyshsk and Sherbakty (Pavlodar Population - 2). As of the end of July, 2008, personal data (date of birth, gender, race, etc.) were collected for 117,300 persons

  7. Survival rates and predictors of survival among colorectal cancer patients in a Malaysian tertiary hospital.

    Science.gov (United States)

    Magaji, Bello Arkilla; Moy, Foong Ming; Roslani, April Camilla; Law, Chee Wei

    2017-05-18

    Colorectal cancer is the third most commonly diagnosed malignancy and the fourth leading cause of cancer-related death globally. It is the second most common cancer among both males and females in Malaysia. The economic burden of colorectal cancer is likely to increase over time owing to its current trend and aging population. Cancer survival analysis is an essential indicator for early detection and improvement in cancer treatment. However, there was a scarcity of studies concerning survival of colorectal cancer patients as well as its predictors. Therefore, we aimed to determine the 1-, 3- and 5-year survival rates, compare survival rates among ethnic groups and determine the predictors of survival among colorectal cancer patients. This was an ambidirectional cohort study conducted at the University Malaya Medical Centre (UMMC) in Kuala Lumpur, Malaysia. All Malaysian citizens or permanent residents with histologically confirmed diagnosis of colorectal cancer seen at UMMC from 1 January 2001 to 31 December 2010 were included in the study. Demographic and clinical characteristics were extracted from the medical records. Patients were followed-up until death or censored at the end of the study (31st December 2010). Censored patients' vital status (whether alive or dead) were cross checked with the National Registration Department. Survival analyses at 1-, 3- and 5-year intervals were performed using the Kaplan-Meier method. Log-rank test was used to compare the survival rates, while Cox proportional hazard regression analysis was carried out to determine the predictors of 5-year colorectal cancer survival. Among 1212 patients, the median survival for colorectal, colon and rectal cancers were 42.0, 42.0 and 41.0 months respectively; while the 1-, 3-, and 5-year relative survival rates ranged from 73.8 to 76.0%, 52.1 to 53.7% and 40.4 to 45.4% respectively. The Chinese patients had the lowest 5-year survival compared to Malay and Indian patients. Based on the 814

  8. Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line

    Directory of Open Access Journals (Sweden)

    Ali NM

    2016-06-01

    Full Text Available Norlaily Mohd Ali,1 M Nadeem Akhtar,2 Huynh Ky,3 Kian Lam Lim,1 Nadiah Abu,4 Seema Zareen,2 Wan Yong Ho,5 Han Kiat Alan-Ong,1 Sheau Wei Tan,6 Noorjahan Banu Alitheen,4 Jamil bin Ismail,2 Swee Keong Yeap,6 Tunku Kamarul7 1Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Selangor, 2Department of Industrial Biotechnology, Faculty of Industrial Sciences & Technology, Universiti Malaysia Pahang, Pahang, Malaysia; 3Department of Agriculture Genetics and Breeding, College of Agriculture and Applied Biology, Cantho University, CanTho City, Vietnam; 4Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 5School of Biomedical Sciences, The University of Nottingham Malaysia Campus, 6Institute of Bioscience, Universiti Putra Malaysia, Selangor, 7Tissue Engineering Group, National Orthopaedic Centre of Excellence for Research and Learning, Department of Orthopaedic Surgery, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia Abstract: Known as naturally occurring biologically active compounds, flavokawain A and B are the leading chalcones that possess anticancer properties. Another flavokawain derivative, (E-1-(2'-Hydroxy-4',6'-dimethoxyphenyl-3-(4-methylthiophenylprop-2-ene-1-one (FLS was characterized with 1H-nuclear magnetic resonance, electron-impact mas spectrometry, infrared spectroscopy, and ultraviolet (1H NMR, EI-MS, IR, and UV spectroscopic techniques. FLS cytotoxic efficacy against human cancer cells (MCF-7, MDA-MB-231, and MCF-10A resulted in the reduction of IC50 values in a time- and dose-dependent mode with high specificity on MCF-7 (IC50 of 36 µM at 48 hours against normal breast cell MCF-10A (no IC50 detected up to 180 µM at 72 hours. Light, scanning electron, and fluorescent microscopic analysis of MCF-7 cell treated with 36 µM of FLS displayed cell shrinkage, apoptotic body, and DNA fragmentation. Additionally, induction of G2/M cell

  9. Radio-ecological conditions of band coniferous forests

    International Nuclear Information System (INIS)

    Strilchuk, Yu.G.; Osintsev, A.Yu.; Kuzin, D.E.; Bryantseva, N.V.; Tonevitskaya, O.V.; Zhadyranova, A.A.; Kashirskij, V.V.; Korovina, O.Yu.; Lukashenko, S.N.

    2008-01-01

    , was investigated along six profiles spacing 2 kilometers between points of investigation. Remaining territory of forests was investigated by the use of small-scale net spacing 10x20 km. Exceeding concentrations of radionuclides in the environment has been revealed on the lands limited by: from the North - Kurchatov - Malaya Vladimirovka, and from the South - Chagan - Dzhelandy. Specific activity of radionuclides in soil lies within the limits: 137 Cs 2 , 90 Sr 2 , 239+240 Pu 2 Bq/kg what exceeds the background values for 25, 18 and over 100 times, respectively. The majority of newly introduced radionuclides remain in the top 10 cm of the soil (about 80-90%). At the same time, major accumulation of the radionuclides has been registered in the forest litter. Maximal values of specific activity achieve the following numbers: 137 Cs - 6.3*10 2 , 90 Sr - 2*10 2 Bq/kg. Exceeding contents of 137 Cs, 90 Sr, 239+240 Pu at investigated territories were mainly registered within radioactive fallout traces of the first nuclear explosion. No exceeding over background values has deen registered on other lands

  10. Book Reviews

    Directory of Open Access Journals (Sweden)

    Raymond L. Bryant

    1999-04-01

    Full Text Available - R.H. Barnes, Janet Hoskins, Biographical objects; How things tell the stories of people’s lives. London: Routledge, 1998, x + 213 pp. - Peter Boomgaard, Ann Kumar, Java and modern Europe; Ambiguous encounters. Richmond, Surrey: Curzon, 1997, vii + 472 pp. - Peter Boomgaard, Lenore Manderson, Sickness and the state; Health and illness in colonial Malaya, 1870-1940. Cambridge: Cambridge University Press, 1996, xix + 315 pp. - Matthew Isaac Cohen, Bambang Widoyo, Gapit; 4 naskah drama berbahasa Jawa: Rol, Leng, Tuk dan Dom. Yogyakarta: Yayasan Benteng Budaya, 1998, xiv + 302 pp. - James T. Collins, Bernd Nothofer, Reconstruction, classification, description; Festschrift in honor of Isidore Dyen. Hamburg: Abera, 1996, xiv + 259 pp. - J.R. Flenley, Kristina R.M. Beuning, Modern pollen rain, vegetation and climate in lowland East Java, Indonesia. Rotterdam: Balkema, 1996, 51 pp. + 49 plates. [Modern Quaternary Research in Southeast Asia 14.] - Gregory Forth, Karl-Heinze Kohl, Der Tod der Riesjungfrau; Mythen, Kulte und Allianzen in einer ostindonesischen Lokalkultur. Stuttgart: Kohlhammer, 1998, 304 pp. [Religionsethnologische Studien des Frobenius-Instituts Frankfurt am Main, Band I.] - J. van Goor, Brook Barrington, Empires, imperialism and Southeast Asia; Essays in honour of Nicholas Tarling. Clayton, Victoria: Monash Asia Institute, 1997, v + 250 pp. [Monash Papers on Southeast Asia 43.] - Mies Grijns, Penny van Esterik, Women of Southeast Asia. DeKalb: Center for Southeast Asian Studies, Northern Illinois University, 1996, xiv + 229 pp. ‘Monographs on Southeast Asia, Occasional Paper 17; Second, revised edition.] - Hans Hagerdal, Alfons van der Kraan, Bali at war; A history of the Dutch-Balinese conflict of 1846-49. Clayton, Victoria: Centre of Southeast Asian Studies, Monash University, 1995, x + 240 pp. [Monash Papers on Southeast Asia 34]. - Volker Heeschen, Jurg Wassmann, Das Ideal des leicht gebeugten Menschen; Eine ethnokognitive

  11. Risk factors for pneumonia among patients with Parkinson's disease: a Taiwan nationwide population-based study

    Directory of Open Access Journals (Sweden)

    Chang YP

    2016-04-01

    Full Text Available Yang-Pei Chang,1 Chih-Jen Yang,2 Kai-Fang Hu,3 A-Ching Chao,4 Yu-Han Chang,5 Kun-Pin Hsieh,6 Jui-Hsiu Tsai,7 Pei-Shan Ho,8,9 Shen-Yang Lim101Department of Neurology, 2Department of Internal Medicine, 3Department of Dentistry, Kaohsiung Municipal Ta-Tung Hospital, 4Department of Neurology, College of Medicine, 5Department of Management, Kaohsiung Municipal Ta-Tung Hospital, 6School of Pharmacy, College of Pharmacy, 7Department of Psychiatry, Kaohsiung Municipal Ta-Tung Hospital, 8Faculty of Dental Hygiene, College of Dental Medicine, Kaohsiung Medical University, 9Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan, Republic of China; 10Faculty of Medicine, University of Malaya, Kuala lumpur, MalaysiaObjective: Pneumonia is the leading cause of death in patients with Parkinson’s disease (PD. However, few studies have been performed to explore the risk factors for pneumonia development in patients with PD.Methods: We conducted a nationwide population-based cohort study of patients with PD to identify the risk factors for these patients developing pneumonia. Participants with newly diagnosed PD between 2000 and 2009 were enrolled from the 2000–2010 National Health Insurance Research Database in Taiwan. We compared patients with PD with an incidence of hospitalization with pneumonia vs those without, and Cox proportional hazard models were used to estimate the risk of pneumonia.Results: Of the 2,001 enrolled patients (mean follow-up duration 5.8 years, range: 2.7–14.7 years, 381 (19.0% had an incidence of hospitalization with pneumonia during the study period. Multivariate Cox proportional hazards analysis identified older age group (≥80 years of age, hazard ratio [HR] =3.15 [95% confidence interval 2.32–4.28], male sex (HR =1.59 [1.29–1.96], certain geographic regions (northern, HR =1.36 [1.04–1.78], southern and eastern, HR =1.40 [1.05–1.88], rural areas (HR =1.34 [1.05–1.72], chronic heart

  12. Suppression of microRNA-629 enhances sensitivity of cervical cancer cells to 1′S-1′-acetoxychavicol acetate via regulating RSU1

    Directory of Open Access Journals (Sweden)

    Phuah NH

    2017-03-01

    Full Text Available Neoh Hun Phuah,1 Mohamad Nurul Azmi,2 Khalijah Awang,2 Noor Hasima Nagoor1,3 1Faculty of Science, Institute of Biological Science (Genetics and Molecular Biology, 2Faculty of Science, Department of Chemistry, Centre for Natural Product Research and Drug Discovery (CENAR, 3Centre for Research in Biotechnology for Agriculture (CEBAR, University of Malaya, Kuala Lumpur, Malaysia Background: Cervical cancer is the fourth most frequent malignancy affecting women worldwide, but drug resistance and toxicities remain a major challenge in chemotherapy. The use of natural compounds is promising because they are less toxic and able to target multiple signaling pathways. The 1'S-1'-acetoxychavicol acetate (ACA, a natural compound isolated from wild ginger Alpinia conchigera, induced cytotoxicity on various cancer cells including cervical cancer. MicroRNAs (miRNAs are short noncoding RNAs that regulate numerous biological processes, such as apoptosis and chemosensitivity. Past studies reported that miR-629 is upregulated in many cancers, and its expression was altered in ACA-treated cervical cancer cells. However, the role of miR-629 in regulating sensitivity toward ACA or other anticancer agents has not been reported. Hence, this study aims to investigate the role of miR-629 in regulating response toward ACA on cervical cancer cells.  Methods: The miR-629 expression following transfection with miR-629 hairpin inhibitor and hairpin inhibitor negative control was measured using quantitative real-time polymerase chain reaction (RT-qPCR. The 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT assay was used to investigate sensitivity toward ACA. Apoptosis was detected using Annexin V/propidium iodide and Caspase 3/7 assays. The gene target for miR-629 was identified using miRNA target prediction programs, luciferase reporter assay and Western blots. Gene overexpression studies were performed to evaluate its role in regulating response toward ACA

  13. Status and prospect of R and D aimed at application of nuclear reactors for seawater desalination in Russia

    International Nuclear Information System (INIS)

    Zverev, K.V.; Baranaev, Y.D.; Toshinsky, G.I.; Polunichev, V.I.; Romenkov, A.A.; Shamanin, V.G.; Podberezny, V.L.

    2004-01-01

    In the document 'Strategy of Nuclear Power Development in Russia for the First Half of XXI Century', approved by the Government of the RF, seawater desalination is considered as a prospective area of application of the small-sized nuclear power plants (SNPP). Taking into account vast water resources of Russia evenly distributed over the territory of the country, seawater desalination is not a vital domestic demand for this country. Therefore, the R and D activities of the RF MINATOM institutions on nuclear desalination are aimed mainly at the assessment of implementation of the SNPP based nuclear desalination system in the developing countries suffering from the lack of fresh water supply. Within these activities, analysis of engineering and economical problems related to optimisation of the use of different type nuclear reactors as a source of electricity and heat for seawater desalination plants has been performed. The objective of the work is to develop scientific and technological basis for comprehensive design studies required for practical implementation of the projects. An important factor stimulating the R and D on nuclear desalination is rather active involvement of the MINATOM's institutions in the various activities in this field organised and coordinated by the IAEA. Since 1998, SRC RF-IPPE, OKBM, ENTEK, MALAYA ENERGETIKA, JSC, and VNIPI PROMTECHNOLOGIYI etc. have been participants of the IAEA Coordinated Research Program (CRP) on 'Optimization of Coupling of Nuclear Reactor and Desalination System'. This work is being carried out within the framework of special Russian Project: 'Use of Small Size Russian Nuclear Reactors as Power Source for Nuclear Desalination Complexes: Optimization of Coupling Schemes, Design and Economical Characteristics'. The small nuclear reactors KLT-40C, NIKA and RUTA are considered in the study. In 2002, IAEA initiates new CRP 'Economic Research on, and Assessment of, selected Nuclear Desalination Projects and Case Studies

  14. Automated classification of tropical shrub species: a hybrid of leaf shape and machine learning approach

    Directory of Open Access Journals (Sweden)

    Miraemiliana Murat

    2017-09-01

    Full Text Available Plants play a crucial role in foodstuff, medicine, industry, and environmental protection. The skill of recognising plants is very important in some applications, including conservation of endangered species and rehabilitation of lands after mining activities. However, it is a difficult task to identify plant species because it requires specialized knowledge. Developing an automated classification system for plant species is necessary and valuable since it can help specialists as well as the public in identifying plant species easily. Shape descriptors were applied on the myDAUN dataset that contains 45 tropical shrub species collected from the University of Malaya (UM, Malaysia. Based on literature review, this is the first study in the development of tropical shrub species image dataset and classification using a hybrid of leaf shape and machine learning approach. Four types of shape descriptors were used in this study namely morphological shape descriptors (MSD, Histogram of Oriented Gradients (HOG, Hu invariant moments (Hu and Zernike moments (ZM. Single descriptor, as well as the combination of hybrid descriptors were tested and compared. The tropical shrub species are classified using six different classifiers, which are artificial neural network (ANN, random forest (RF, support vector machine (SVM, k-nearest neighbour (k-NN, linear discriminant analysis (LDA and directed acyclic graph multiclass least squares twin support vector machine (DAG MLSTSVM. In addition, three types of feature selection methods were tested in the myDAUN dataset, Relief, Correlation-based feature selection (CFS and Pearson’s coefficient correlation (PCC. The well-known Flavia dataset and Swedish Leaf dataset were used as the validation dataset on the proposed methods. The results showed that the hybrid of all descriptors of ANN outperformed the other classifiers with an average classification accuracy of 98.23% for the myDAUN dataset, 95.25% for the Flavia

  15. Predictors of mortality within prison and after release among persons living with HIV in Indonesia

    Directory of Open Access Journals (Sweden)

    Culbert GJ

    2017-03-01

    Full Text Available Gabriel J Culbert,1,2 Forrest W Crawford,3–5 Astia Murni,6 Agung Waluyo,2 Alexander R Bazazi,7,8 Junaiti Sahar,2 Frederick L Altice7–9 1Department of Health Systems Science, College of Nursing, University of Illinois at Chicago, Chicago, IL, USA; 2Center for HIV/AIDS Nursing Research, Faculty of Nursing, Universitas Indonesia, Depok, Indonesia; 3Department of Biostatistics, Yale School of Public Health, 4Operations, Yale School of Management, 5Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA; 6Directorate General of Corrections, Indonesian Ministry of Law and Human Rights, Jakarta, Indonesia; 7Department of Epidemiology of Microbial Diseases, School of Public Health, 8Department of Medicine, Section of Infectious Diseases, AIDS Program, School of Medicine, Yale University, New Haven, CT, USA; 9Centre of Excellence for Research in AIDS (CERiA, University of Malaya, Kuala Lumpur, Malaysia Objectives: HIV-related mortality is increasing in Indonesia, where prisons house many people living with HIV and addiction. We examined all-cause mortality in HIV-infected Indonesian prisoners within prison and up to 24 months postrelease. Materials and methods: Randomly selected HIV-infected male prisoners (n=102 from two prisons in Jakarta, Indonesia, completed surveys in prison and were followed up for 2 years (until study completion or until they died or were lost to follow-up. Death dates were determined from medical records and interviews with immediate family members. Kaplan–Meier and Cox proportional hazards regression models were analyzed to identify mortality predictors. Results: During 103 person-years (PYs of follow-up, 15 deaths occurred, including ten in prison. The crude mortality rate within prison (125.2 deaths per 1,000 PYs was surpassed by the crude mortality rate (215.7 deaths per 1,000 PYs in released prisoners. HIV-associated opportunistic infections were the most common probable cause of death

  16. Relapse to opioid use in opioid-dependent individuals released from compulsory drug detention centres compared with those from voluntary methadone treatment centres in Malaysia: a two-arm, prospective observational study.

    Science.gov (United States)

    Wegman, Martin P; Altice, Frederick L; Kaur, Sangeeth; Rajandaran, Vanesa; Osornprasop, Sutayut; Wilson, David; Wilson, David P; Kamarulzaman, Adeeba

    2017-02-01

    31 days [IQR 26-32] vs 352 days [256-unestimable], log rank test, p<0·0001). VTC participants had an 84% (95% CI 75-90) decreased risk of opioid relapse after adjustment for control variables and inverse propensity of treatment weights. Time-varying effect modelling revealed the largest hazard ratio reduction, at 91% (95% CI 83-96), occurs during the first 50 days in the community. Opioid-dependent individuals in CDDCs are significantly more likely to relapse to opioid use after release, and sooner, than those treated with evidence-based treatments such as methadone, suggesting that CDDCs have no role in the treatment of opioid-use disorders. The World Bank Group, Doris Duke Charitable Foundation, National Institute on Drug Abuse, Australian National Health & Medical Research Council, National Institute of Mental Health, and the University of Malaya-Malaysian Ministry of Higher Education High Impact Research Grant. Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND license. Published by Elsevier Ltd.. All rights reserved.

  17. Book Reviews

    Directory of Open Access Journals (Sweden)

    Chanatip Kesavadhana

    2000-01-01

    -Bintuni, and hinterland. Leiden: DSALCUL, Jakarta: ISIR, 1997, vii + 120 pp. [Irian Jaya Source Materials 15.] - Robert W, Hefner, Daniel Chirot, Essential outsiders: Chinese and Jews in the modern transformation of Southeast Asia and Central Europe. Seattle: University of Washington Press, 1997, vii + 335 pp., Anthony Reid (eds. - Bob Hering, Lambert Giebels, Soekarno, Nederlandsch onderdaan; Biografie 1901-1950. Amsterdam: Bert Bakker, 1999, 531 pp. - Karin van Lotringen, David Brown, The state and ethnic politics in Southeast Asia. London: Routledge, 1994, xxi + 354 pp. - Ethan Mark, Takashi Shiraishi, Approaching Suharto’s Indonesia from the margins. Ithaca, NY: Cornell University Southeast Asia Program, 1994, 153 pp. - Harry Poeze, J.A. Manusama, Eigenlijk moest ik niet veel hebben van de politiek; Herinneringen aan mijn leven in de Oost 1910-1953. Utrecht: Moluks Historisch Museum, ‘s-Gravenhage: Bintang, 1999, 301 pp. - Nico Schulte Nordholt, Hans Antlöv, Exemplary centre, administrative periphery; Rural leadership and the New Order in Java. Richmond, Surrey: Curzon Press, 1995, xi + 222 pp. [Nordic Institute of Asian Studies, Monograph Series 68.] - Cornelia M.I. van der Sluys, Danielle C. Geirnaert-Martin, The woven land of Laboya; Socio-cosmic ideas and values in West Sumba, eastern Indonesia. Leiden: Centre for Non Western Studies, Leiden University, 1992, xxxv + 449 pp. [CNWS Publications 11.] - Nicholas Tarling, Tom Marks, The British acquisition of Siamese Malaya (1896-1909. Bangkok: White Lotus Press, 1997, vii + 167 pp. - B.J. Terwiel, Chanatip Kesavadhana, Chulalangkorn, roi de Siam: Itineraire d’un voyage à Java en 1886. Paris: EHESS, 1993, vi + 204 pp. [Cahier d’Archipel 20.] - Jaap Timmer, Polly Wiessner, Historical vines; Enga networks of exchange, ritual, and warfare in Papua New Guinea, with translations and assistance by Nitze Pupu. Washington: Smithsonian Institution Press, 1998, xvii + 494 pp., Akii Tumu (eds. - Robert van Niel, Margaret

  18. Book Reviews

    Directory of Open Access Journals (Sweden)

    Jerome Rousseau

    1984-04-01

    annotated translation by Virginia Matheson & Barbara Watson Andaya. Kuala Lumpur: Oxford University Press 1982, XIV + 476 pp., maps, ills. - Gerard A. Nagelkerke, J.A. de Moor, Indisch Militair Tijdschrift (1870-1942: A selective and annotated bibliography. The Hague: Sectie Militaire Geschiedenis van de Landmachtstaf; Leiden: Centre for the History of European Expansion. 1983. XIV + 237 pp. - Gert J. Oostindie, Albert Helman, De foltering van Eldorado. Een ecologische geschiedenis van de vijf Guyana’s. ‘s-Gravenhage, Nijgh & Van Ditmar, 1983. 495 pp. - Gerard Persoon, G. Adrian Horridge, 1 The Prahu, traditional sailing boat of Indonesia, Oxford, O.U.P.,1981. xv + 106 pp.'2 The lashed-lug boat of the Eastern Archipelagoes, Maritime Monographs and reports no. 54, National Maritime Museum, London, 1982, 75 pp. - Harry A. Poeze, H. Coerts, De A.R.P. en Nieuw-Guinea, Historische analyse van een partijcrisis. Franeker: Wever, 1983, 104 blz. - S.O. Robson, John U. Wolff, Communicative codes in central Java, Data Paper Number 116, Southeast Asia program, Department of Asian studies, Cornell University, Ithaca N.Y., June 1982. X + 188 pp., Soepomo Poedjosoedarmo (eds. - Jerome Rousseau, Harmut K. Hildebrand, Die Wildbeutergruppen Borneos. Müncher Ethnologische Abhandlungen, no. 2. München: Minerva Publikation, 1982. xxvii + 374 pp., 11 maps, 2 tables, bibliography, English summary - T.B. Simatupang, Jan Bank, Katholieken en de Indonesische Revolutie, Baarn: Ambo, 1983, 576 pp. - H. Steinhauer, Richard McGinn, Outline of Rejang syntax, NUSA Linguistic studies of Indonesian and other languages in Indonesia 14, Jakarta 1982, xvi + 76 pp. - Heather Sutherland, Yeo Kim Wah, The politics of decentralization. Colonial controversy in Malaya 1920-1929; Oxford University Press/Institute of Southeast Asian studies, Kuala Lumpur, 1982, xiv, 395 pp., map and photographs. - Rudolf van Zantwijk, Jerome A. Offner, Law and politics in Aztec Texcoco, Cambridge Latin American studies nr. 44

  19. Stars Just Got Bigger - A 300 Solar Mass Star Uncovered

    Science.gov (United States)

    2010-07-01

    P. Crowther et al.). The team is composed of Paul A. Crowther, Richard J. Parker, and Simon P. Goodwin (University of Sheffield, UK), Olivier Schnurr (University of Sheffield and Astrophysikalisches Institut Potsdam, Germany), Raphael Hirschi (Keele University, UK), and Norhasliza Yusof and Hasan Abu Kassim (University of Malaya, Malaysia). ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 14 countries: Austria, Belgium, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory and VISTA, the world's largest survey telescope. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the world's biggest eye on the sky".

  20. Event coverage: ESMO Asia Congress returns to Singapore

    Directory of Open Access Journals (Sweden)

    Editorial Office

    2016-12-01

    , the Myanmar Oncology Society (MOS was represented by Dr. Shu Mon, who is based at the Thurein Mon Clinic in Yangon, Myanmar. During the congress, she gave a presentation on breast cancer management that is specific to the Myanmar experience. According to Dr. Shu Mon, there are only 30 qualified medical oncologists serving the whole of Myanmar, a country with a population of about 51 million people. On establishing collaborations with an academic journal, she said, “MOS is willing to work with a journal such as AMOR to promote the oncology research in Myanmar provided that there are suitable opportunities that both sides could agree on.”During the congress, Assoc. Prof. Dr. Ho Gwo Fuang, the guest managing editor for AMOR’s upcoming special issue and a representative of the Malaysian Oncological Society (MOS at ESMO Asia 2016, was featured as one of the panelists of the ESMO-COS-MOS-NZSO Joint Symposium on ‘New insights into gastrointestinal cancers’. Dr. Ho, who is a medical oncologist at Malaysia’s University Malaya Medical Centre, delivered a talk entitled ‘Adjuvant aspirin for colorectal cancer? A cross-Asia collaborative effort’, a multi-nation initiative involving Singapore, Malaysia, and other Asia Pacific countries. His presentation offered strong scientific and observational data to support the adjuvant use of aspirin in reducing the formation of polyps and metastases after colorectal cancer diagnosis. Towards the end of his presentation, Dr. Ho highlighted the ongoing curation of AMOR’s Special Issue and invited his peers to submit papers to the journal for consideration.