Rain Sepp - kontorita juht ülemaailmses äris / Riina Kallas

Index Scriptorium Estoniae

Kallas, Riina

2005-01-01

Mobiiltelefonilogosid ning -helinaid müüva Jipii! portaali rahvusvahelise võrgu juht Rain Sepp ettevõtte arengust ja teenustest, tööst rahvusvahelise võrgu juhina, töö spetsiifilisusest, Eesti meeskonnast ning Läti, Leedu, Soome ja Londoni tiimis valitseva tööõhkkonna erinevustest. Vt. samas: 10% muusikarahast tuleb helinast; iTouch plc; www.jippii.ee

Aasta Põllumees 2007 on Ermo Sepp / Silja Lättemäe

Index Scriptorium Estoniae

Lättemäe, Silja, 1952-

2007-01-01

Tallinnas Olümpia konverentsikeskuses toimunud Aasta Põllumehe konverentsil õnnitles konkursi võitjat ja nominente president Toomas Hendrik Ilves. Aasta Põllumees 2007 on seakasvataja Ermo Sepp Lääne-Virumaalt Tapa vallast Patika külast; Vt. samas lk. 11 lühiintervjuud Lauri Vaiksaarega, kes esindab konkursi Aasta Põllumees 2007 toetajat Hansa Liisingut

Märt Agu käib isa Mait Agu jälgedes / Heili Sibrits

Index Scriptorium Estoniae

Sibrits, Heili, 1977-

2001-01-01

Koreograafi ja tantsupedagoogi Mait Agu poeg Märt Agu on Eesti Tantsuagentuuri tantsija ja Pedagoogilise Instituudi tantsujuhtimise viimase kursuse üliõpilane, kes esineb revüüteatris "Bel-⁹tage"

Taifuun nimega Valimised on möödas / Mait Klaassen

Index Scriptorium Estoniae

Klaassen, Mait, 1955-

2005-01-01

Ilmunud ka: Põhjarannik 20. okt., lk. 2, Severnoje Poberezhje 20. okt., lk. 2, Meie Maa 20. okt., lk. 2, Sakala 21. okt., lk. 2, Vali Uudised 21. okt. lk. 2, Koit, Järva Teataja 22. okt. lk. 6,2, Lääne Elu 25. okt., lk. 2, Harjumaa 25. okt. lk. 2, Vooremaa 27. okt. lk. 2. Parlamendisaadik, Reformierakonna liige Mait Klaassen teeb kokkuvõtte lõppenud kohalikest valimistest

HIV infection is associated with preservation of MAIT cells in the lungs but alteration of their phenotype and T cell receptor repertoire

DEFF Research Database (Denmark)

Wong, E. B.; Xulu, B.; Prakadan, S.

2016-01-01

Tuberculosis remains the leading cause of death in HIV-positive people. A better understanding of the impact of HIV on lung immunity may lead to novel immunotherapeutic interventions. MAIT cells are tissue-homing donor-unrestricted T cells with broad anti-microbial activity. HIV infection causes ...... to determine the mechanisms underlying the altered phenotypes of lung-resident MAITs and whether these can be targeted to improve anti-microbial lung immunity in people living with HIV....

Grand Prix' võitis reklaamfilmistuudio Division / Mait Laas, Jaak Lõhmus, Ants Vist...[jt.] ; interv. Tiiu Leis

Index Scriptorium Estoniae

1998-01-01

Pärnu filmipäevadel 'Do Re Vi' võitis Grand Prix ehk skulptuuri 'Oskar & Ella' reklaamistuudio 'Division', kullatud videokassetid said 'Polarfilm' (dok. film), Martin Pedanik (video) ja Edith Sepp ('Tingimustega Tallinnas'); osalejate M. Laasi, J. Lõhmuse, A. Visti ja I. Raagi kommentaare ürituse kohta;

MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression.

Directory of Open Access Journals (Sweden)

Christopher R Shaler

2017-06-01

Full Text Available Superantigens (SAgs are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a "cytokine storm" with severe and sometimes life-threatening consequences typically encountered in toxic shock syndrome (TSS. Given the rapidity with which TSS develops, designing timely and truly targeted therapies for this syndrome requires identification of key mediators of the cytokine storm's initial wave. Equally important, early host responses to SAgs can be accompanied or followed by a state of immunosuppression, which in turn jeopardizes the host's ability to combat and clear infections. Unlike in mouse models, the mechanisms underlying SAg-associated immunosuppression in humans are ill-defined. In this work, we have identified a population of innate-like T cells, called mucosa-associated invariant T (MAIT cells, as the most powerful source of pro-inflammatory cytokines after exposure to SAgs. We have utilized primary human peripheral blood and hepatic mononuclear cells, mouse MAIT hybridoma lines, HLA-DR4-transgenic mice, MAIThighHLA-DR4+ bone marrow chimeras, and humanized NOD-scid IL-2Rγnull mice to demonstrate for the first time that: i mouse and human MAIT cells are hyperresponsive to SAgs, typified by staphylococcal enterotoxin B (SEB; ii the human MAIT cell response to SEB is rapid and far greater in magnitude than that launched by unfractionated conventional T, invariant natural killer T (iNKT or γδ T cells, and is characterized by production of interferon (IFN-γ, tumor necrosis factor (TNF-α and interleukin (IL-2, but not IL-17A; iii high-affinity MHC class II interaction with SAgs, but not MHC-related protein 1 (MR1 participation, is required for MAIT cell activation; iv MAIT cell responses to SEB can occur in a T cell receptor (TCR Vβ-specific manner but are largely contributed by IL-12 and IL-18; v as MAIT cells are primed by SAgs, they also begin to

Rasked vestlused. Kuidas ma talle seda ütlen / Irene Metsis, Sami Seppänen, Peep Sooman ; intervjueerinud Heli Lehtsaar

Index Scriptorium Estoniae

Metsis, Irene

2009-01-01

Skanska EMV administratsioonijuhi Irene Metsise, AS-i Elisa Eesti tegevdirektori Sami Seppäneni ja Pindi Kinnisvara juhatuse liikme Peep Soomani soovitused negatiivse sõnumi edastamiseks töötajale. Vt. samas: 4 nõuannet juhile, kuidas end keeruliseks vestluseks ette valmistada

Isepäine modernist Toomas Rein / Toomas Rein ; intervjueerinud Mait Väljas ja Reet Varblane

Index Scriptorium Estoniae

Rein, Toomas, 1940-

2010-01-01

23. aprillil avatakse Eesti Arhitektuurimuuseumis arhitekt Toomas Reinu 70. sünnipäevale pühendatud näitus. Kataloogi ja näituse on koostanud Toomas Rein ja Mait Väljas, kujundanud Tiit Jürna. Toomas Rein endast, oma loomingust, eeskujudest, näitusest, nõukogude perioodi hoonete olukorrast, viimase aja töödest, koostööst teiste arhitektidega, teostamata projektidest

T-cell receptor repertoire of human peripheral CD161hiTRAV1-2+ MAIT cells revealed by next generation sequencing and single cell analysis.

Science.gov (United States)

Held, Kathrin; Beltrán, Eduardo; Moser, Markus; Hohlfeld, Reinhard; Dornmair, Klaus

2015-09-01

Mucosal-associated invariant T (MAIT) cells are a T-cell subset that expresses a conserved TRAV1-2 (Vα7.2) T-cell receptor (TCR) chain and the surface marker CD161. They are involved in the defence against microbes as they recognise small organic molecules of microbial origin that are presented by the non-classical MHC molecule 1 (MR1). MAIT cells express a semi-restricted TCR α chain with TRAV1-2 preferentially linked to TRAJ33, TRAJ12, or TRAJ20 which pairs with a limited set of β chains. To investigate the TCR repertoire of human CD161(hi)TRAV1-2(+) T cells in depth we analysed the α and β chains of this T-cell subset by next generation sequencing. Concomitantly we analysed 132 paired α and β chains from single cells to assess the αβ pairing preferences. We found that the CD161(hi)TRAV1-2(+) TCR repertoire in addition to the typical MAIT TCRs further contains polyclonal elements reminiscent of classical αβ T cells. Copyright © 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Uhked naised / Kozik, Eerika; Tomingas, Triin; Sepp, Karin; Liik, Kadi; Kliimask, Katrin; Saunpere, Anne ; tekst Kärt Kross

Index Scriptorium Estoniae

2007-01-01

Mille üle oled enda juures tõeliselt uhke, mida võid enda kiituseks öelda? Küsimusele vastavad Starland Salongi omanik ja Loyd Tootmine OÜ osanik Eerika Kozik, psühholoog Triin Tomingas, Kontuur Leo Burnett projektidirektor Karin Sepp, Tallinna Ülikooli õppejõud Kadi Liik, AS Koolibri turundusjuht Katrin Kliimask ja eraettevõtja Anne Saunpere

Pävi Naskali, Marjaana Seppänen & Shahnaj Begum (eds., Ageing, Wellbeing and Climate Change in the Arctic. An interdisciplinary analysis (London: Routledge, 2015

Directory of Open Access Journals (Sweden)

Hermann Óskarsson

2016-03-01

Full Text Available Book review of: Pävi Naskali, Marjaana Seppänen and Shahnaj Begum (eds., Ageing, Wellbeing and Climate Change in the Arctic. An interdisciplinary analysis (London: Routledge’s series on advances in climate change research, 2015

Eestlastest tippjuhid kerge südamega võõrsile leiba teenima ei lähe / Mait Raava, Indrek Neivelt, Maive Rute ; interv. Tuuliki Kasonen-Lins

Index Scriptorium Estoniae

Raava, Mait

2006-01-01

Pro Konsultatsioonide juhtimiskonsultant Mait Raava, Bank Saint Petersburgi nõukogu esimees Indrek Neivelt, Euroopa Komisjoni innovatsiooni ja väikeettevõtluse üksuse direktor Maive Rute vastavad küsimustele, mis puudutavad Eesti juhtide mainet ning töötamist välisriikides

Tähed disainiöös / Mait Summatavet, Risto Räägel, Per Mollerup...[jt.] ; interv. Karin Paulus

Index Scriptorium Estoniae

2007-01-01

Disainiöö raames avati Arhitektuuri- ja Disainigaleriis näitus "Kokkupandavad asjad" ning kuulutati välja konkursi võitjad. Peapreemia võitis läti disaineri Elina Bushmane kokkupandav teelaud, teise koha Jaana Päeva tekstiilist kott, kolmanda koha Ingrem Floreni käekott. Ära märgiti Veiko Liisi kilepiima vutlar. Disainiöö üritustest ning konkursitöödest räägivad Mait Summatavet, Per Mollerup, Simo Heikkilä, Risto Räägel

Estrogen receptor-α mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract

International Nuclear Information System (INIS)

Couse, John F.; Korach, Kenneth S.

2004-01-01

It is generally believed that estrogen receptor-dependent and -independent pathways are involved in mediating the developmental effects of the synthetic estrogen, diethylstilbestrol (DES). However, the precise role and extent to which each pathway contributes to the resulting pathologies remains unknown. We have employed the estrogen receptor knockout (ERKO) mice, which lack either estrogen receptor-α (αERKO or estrogen receptor-β (βERKO), to gain insight into the contribution of each ER-dependent pathway in mediating the effects of neonatal DES exposure in the female and male reproductive tract tissues of the mouse. Estrogen receptor-α female mice exhibited complete resistance to the chronic effects of neonatal DES exposure that were obvious in exposed wild-type animals, including atrophy and epithelial squamous metaplasia in the uterus; proliferative lesions of the oviduct; and persistent cornification of the vaginal epithelium. DES-mediated reduction in uterine Hoxa10, Hoxa11 and Wnt7a expression that occurs wild-type females during the time of exposure was also absent in αERKO females. In the male, αERKO mice exhibited complete resistance to the chronic effects of neonatal DES exposure on the prostate, including decreased androgen receptor levels, epithelial hyperplasia, and increased basal cell proliferation. Although ERβ is highly expressed in the prostate epithelium, DES-exposed βERKO males exhibited all of the effects of neonatal DES exposure that were observed in similarly exposed wild-type males. Therefore, the lack of DES-effects on gene expression and tissue differentiation in the αERKO uterus and prostate provides unequivocal evidence of an obligatory role for ERα in mediating the detrimental actions of neonatal DES exposure in the murine reproductive tract

Gender-specific effects of endogenous testosterone: female alpha-estrogen receptor-deficient C57Bl/6J mice develop glomerulosclerosis.

Science.gov (United States)

Elliot, S J; Berho, M; Korach, K; Doublier, S; Lupia, E; Striker, G E; Karl, M

2007-08-01

Young female mice on a C57Bl/6J (B6) background are considered glomerulosclerosis (GS)-resistant but aging B6 mice develop mild GS. Estrogen deficiency accelerates while estrogen replacement retards GS in young sclerosis-prone oligosyndactyly mutant mice on an ROP background. To explore the effects of sex hormones on glomerular structure and function in the context of gender and genetic background, we studied mice in which the estrogen-receptor (ER) genes alpha- or -beta were deleted (alpha- or betaER knockout (KO)) and crossed into the B6 background. We also studied ovariectomized (Ovx) B6 mice given testosterone. Male and female betaERKO and male alphaERKO mice had no glomerular dysfunction at 9 months of age; however, alphaERKO female mice displayed albuminuria and GS. Ovx prevented glomerular dysfunction in alphaERKO female mice by eliminating endogenous testosterone production while exogenous testosterone induced GS in Ovx B6 mice. Androgen receptor (AR) expression and function was found in microdissected glomeruli and cultured mesangial cells. Testosterone compared to placebo increased both AR expression and TGF-beta1 mRNA levels in glomeruli isolated from female B6 mice. Estrogen deficiency had no deleterious effects on the glomeruli in B6 mice. Our study shows that genetic traits strongly influence the GS-promoting effects of estrogen deficiency while testosterone induces GS in a gender-specific manner.

Mucosal-associated invariant T cells are numerically and functionally deficient in patients with mycobacterial infection and reflect disease activity.

Science.gov (United States)

Kwon, Yong-Soo; Cho, Young-Nan; Kim, Moon-Ju; Jin, Hye-Mi; Jung, Hyun-Ju; Kang, Jeong-Hwa; Park, Ki-Jeong; Kim, Tae-Jong; Kee, Hae Jin; Kim, Nacksung; Kee, Seung-Jung; Park, Yong-Wook

2015-05-01

Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections. The aims of this study were to examine the levels of MAIT cells in pulmonary tuberculosis (TB) and nontuberculous mycobacteria (NTM) lung disease patients, to evaluate the clinical relevance of MAIT cell levels, and to investigate the functions of MAIT cells. Patients with pulmonary TB (n = 35), NTM (n = 29), and healthy controls (n = 75) were enrolled in the study. MAIT cell levels and functions were measured by flow cytometry. Circluating MAIT cell levels were found to be reduced in TB and NTM patients. MAIT cell deficiency reflects a variety of clinical conditions. In particular, MAIT cell numbers were significantly correlated with sputum AFB positivity, extent of disease, hemoglobin levels, lymphocyte counts, CRP and ESR levels. MAIT cells in TB patients failed to produce interferon-γ irrespective of the mode of stimulation, whereas NTM patients displayed a defect in MR1-dependent signaling pathway. Notably, an elevated expression of programmed death-1 was also associated with MAIT cell deficiency in TB. This study shows that MAIT cells are numerically and functionally deficient in TB and NTM patients and these deficiencies could contribute to immune system dysreguation in mycobacterial infection. Copyright © 2015 Elsevier Ltd. All rights reserved.

Activation, Impaired Tumor Necrosis Factor-α Production, and Deficiency of Circulating Mucosal-Associated Invariant T Cells in Patients with Scrub Typhus.

Science.gov (United States)

Kang, Seung-Ji; Jin, Hye-Mi; Won, Eun Jeong; Cho, Young-Nan; Jung, Hyun-Ju; Kwon, Yong-Soo; Kee, Hae Jin; Ju, Jae Kyun; Kim, Jung-Chul; Kim, Uh Jin; Jang, Hee-Chang; Jung, Sook-In; Kee, Seung-Jung; Park, Yong-Wook

2016-07-01

Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections. However, little is known about the role of MAIT cells in Orientia tsutsugamushi infection. Hence, the aims of this study were to examine the level and function of MAIT cells in patients with scrub typhus and to evaluate the clinical relevance of MAIT cell levels. Thirty-eight patients with scrub typhus and 53 health control subjects were enrolled in the study. The patients were further divided into subgroups according to disease severity. MAIT cell level and function in the peripheral blood were measured by flow cytometry. Circulating MAIT cell levels were found to be significantly reduced in scrub typhus patients. MAIT cell deficiency reflects a variety of clinical conditions. In particular, MAT cell levels reflect disease severity. MAIT cells in scrub typhus patients displayed impaired tumor necrosis factor (TNF)-α production, which was restored during the remission phase. In addition, the impaired production of TNF-α by MAIT cells was associated with elevated CD69 expression. This study shows that circulating MAIT cells are activated, numerically deficient, and functionally impaired in TNF-α production in patients with scrub typhus. These abnormalities possibly contribute to immune system dysregulation in scrub typhus infection.

Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage

Science.gov (United States)

Barrett, Caitlyn W.; Reddy, Vishruth K.; Short, Sarah P.; Motley, Amy K.; Lintel, Mary K.; Bradley, Amber M.; Freeman, Tanner; Vallance, Jefferson; Ning, Wei; Parang, Bobak; Poindexter, Shenika V.; Fingleton, Barbara; Chen, Xi; Washington, Mary K.; Wilson, Keith T.; Shroyer, Noah F.; Hill, Kristina E.; Burk, Raymond F.; Williams, Christopher S.

2015-01-01

Patients with inflammatory bowel disease are at increased risk for colon cancer due to augmented oxidative stress. These patients also have compromised antioxidant defenses as the result of nutritional deficiencies. The micronutrient selenium is essential for selenoprotein production and is transported from the liver to target tissues via selenoprotein P (SEPP1). Target tissues also produce SEPP1, which is thought to possess an endogenous antioxidant function. Here, we have shown that mice with Sepp1 haploinsufficiency or mutations that disrupt either the selenium transport or the enzymatic domain of SEPP1 exhibit increased colitis-associated carcinogenesis as the result of increased genomic instability and promotion of a protumorigenic microenvironment. Reduced SEPP1 function markedly increased M2-polarized macrophages, indicating a role for SEPP1 in macrophage polarization and immune function. Furthermore, compared with partial loss, complete loss of SEPP1 substantially reduced tumor burden, in part due to increased apoptosis. Using intestinal organoid cultures, we found that, compared with those from WT animals, Sepp1-null cultures display increased stem cell characteristics that are coupled with increased ROS production, DNA damage, proliferation, decreased cell survival, and modulation of WNT signaling in response to H2O2-mediated oxidative stress. Together, these data demonstrate that SEPP1 influences inflammatory tumorigenesis by affecting genomic stability, the inflammatory microenvironment, and epithelial stem cell functions. PMID:26053663

Biomonitoring of selenoprotein P in human serum by fast affinity chromatography coupled to ICP-MS.

Science.gov (United States)

Heitland, Peter; Köster, Helmut D

2018-04-01

Most of the Se in human serum is bound to selenoprotein P (SEPP1) in which Se is present in form of selenocysteine. The SEPP1 is a new possible biomarker for the Se status and for this reason we developed a fast, simple and reliable method for the quantitative determination of SEPP1 in serum by affinity chromatography coupled to ICP-MS. It is possible to separate SEPP1 from other selenoproteins in serum in only 5 min, which allows high sample throughput in clinical laboratories. Measured and certified concentrations of total Se and Se(SEPP1) are in good agreement for the reference material SRM 1950. The SEPP1 concentration was stable in serum samples of 3 persons for a minimum of 2 weeks. Further results of method validation were described including internal and external quality assurance. The analytical method was applied for a biomonitoring study of the SEPP1 and total Se concentration in human serum of 50 occupationally non-exposed persons living in northern Germany. Concentration ranges and mean concentrations for Se(SEPP1) are 31.1-59.7 and 46.2 μg/L, respectively. The corresponding values for total Se are 62-120 and 83.5 μg/L. The mean percentage of total Se in serum present as SEPP1 is 58%. Copyright © 2018 Elsevier GmbH. All rights reserved.

Maximal exercise increases mucosal associated invariant T cell frequency and number in healthy young men.

Science.gov (United States)

Hanson, Erik D; Danson, Eli; Nguyen-Robertson, Catriona V; Fyfe, Jackson J; Stepto, Nigel K; Bartlett, David B; Sakkal, Samy

2017-11-01

Mucosal associated invariant T (MAIT) cells have properties of the innate and acquired immune systems. While the response to vigorous exercise has been established for most leukocytes, MAIT cells have not been investigated. Therefore, the purpose was to determine if MAIT cell lymphocytosis occurs with acute maximal aerobic exercise and if this response is influenced by exercise duration, cardiovascular fitness, or body composition. Twenty healthy young males with moderate fitness levels performed an extended graded exercise test until volitional fatigue. Peripheral blood mononuclear cells were isolated from venous blood obtained prior and immediately after exercise and were labeled to identify specific T cell populations using flow cytometry. The percentage of MAIT cells relative to total T cells significantly increased from 3.0 to 3.8% and absolute MAIT cell counts increased by 2.2-fold following maximal exercise. MAIT cell subpopulation proportions were unchanged with exercise. Within cytotoxic T lymphocytes (CTL), MAIT cells consisted of 8% of these cells and this remained constant after exercise. MAIT cell counts and changes with exercise were not affected by body composition, VO 2peak , or exercise duration. Maximal exercise doubled MAIT cell numbers and showed preferential mobilization within total T cells but the response was not influenced by fitness levels, exercise duration, or body composition. These results suggest that acute exercise could be used to offset MAIT cell deficiencies observed with certain pathologies. MAIT cells also make up a substantial proportion of CTLs, which may have implications for cytotoxicity assays using these cells.

Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection

Directory of Open Access Journals (Sweden)

Yean K. Yong

2018-03-01

Full Text Available Mucosal-associated invariant T (MAIT cells, defined as CD161++TCR iVα7.2+ T cells, play an important role in the innate defense against bacterial infections, and their functionality is impaired in chronic viral infections. Here, we investigated the frequency and functional role of MAIT cells in chronic hepatitis B virus (HBV infection. The peripheral CD3+CD161++TCR iVα7.2+ MAIT cells in chronic HBV-infected patients and healthy controls were phenotypically characterized based on CD57, PD-1, TIM-3, and CTLA-4, as well as HLA-DR and CD38 expression. The frequency of MAIT cells was significantly decreased among chronic HBV-infected individuals as compared to controls. Expression of CD57, PD-1, CTLA-4, as well as HLA-DR and CD38 on MAIT cells was significantly elevated in chronic HBV-infected individuals relative to controls. The percentage of T cell receptor (TCR iVα7.2+ CD161+ MAIT cells did not correlate with HBV viral load but inversely with HLA-DR on CD4+ T cells and MAIT cells and with CD57 on CD8+ T cells suggesting that decrease of MAIT cells may not be attributed to direct infection by HBV but driven by HBV-induced chronic immune activation. The percentage and expression levels of PD-1 as well as CTLA-4 on MAIT cells inversely correlated with plasma HBV-DNA levels, which may suggest either a role for MAIT cells in the control of HBV infection or the effect of HBV replication in the liver on MAIT cell phenotype. We report that decrease of TCR iVα7.2+ MAIT cells in the peripheral blood and their functions were seemingly impaired in chronic HBV-infected patients likely because of the increased expression of PD-1.

Selenoprotein P is the essential selenium transporter for bones.

Science.gov (United States)

Pietschmann, Nicole; Rijntjes, Eddy; Hoeg, Antonia; Stoedter, Mette; Schweizer, Ulrich; Seemann, Petra; Schomburg, Lutz

2014-05-01

Selenium (Se) plays an important role in bone physiology as best reflected by Kashin-Beck disease, an endemic Se-dependent osteoarthritis. Bone development is delayed in children with mutations in SECIS binding protein 2 (SBP2), a central factor for selenoprotein biosynthesis. Circulating selenoprotein P (SePP) is positively associated with bone turnover in humans, yet its function for bone homeostasis is not known. We have analysed murine models of altered Se metabolism. Most of the known selenoprotein genes and factors needed for selenoprotein biosynthesis are expressed in bones. Bone Se is not associated with the mineral but exclusively with the organic matrix. Genetic ablation of Sepp-expression causes a drastic decline in serum (25-fold) but only a mild reduction in bone (2.5-fold) Se concentrations. Cell-specific expression of a SePP transgene in hepatocytes efficiently restores bone Se levels in Sepp-knockout mice. Of the two known SePP receptors, Lrp8 was detected in bones while Lrp2 was absent. Interestingly, Lrp8 mRNA concentrations were strongly increased in bones of Sepp-knockout mice likely in order to counteract the developing Se deficiency. Our data highlight SePP as the essential Se transporter to bones, and suggest a novel feedback mechanism for preferential uptake of Se in Se-deprived bones, thereby contributing to our understanding of hepatic osteodystrophy and the consistent bone phenotype observed in subjects with inherited selenoprotein biosynthesis mutations.

Epigenetic silencing of V(DJ recombination is a major determinant for selective differentiation of mucosal-associated invariant t cells from induced pluripotent stem cells.

Directory of Open Access Journals (Sweden)

Yutaka Saito

Full Text Available Mucosal-associated invariant T cells (MAITs are innate-like T cells that play a pivotal role in the host defense against infectious diseases, and are also implicated in autoimmune diseases, metabolic diseases, and cancer. Recent studies have shown that induced pluripotent stem cells (iPSCs derived from MAITs selectively redifferentiate into MAITs without altering their antigen specificity. Such a selective differentiation is a prerequisite for the use of MAITs in cell therapy and/or regenerative medicine. However, the molecular mechanisms underlying this phenomenon remain unclear. Here, we performed methylome and transcriptome analyses of MAITs during the course of differentiation from iPSCs. Our multi-omics analyses revealed that recombination-activating genes (RAG1 and RAG2 and DNA nucleotidylexotransferase (DNTT were highly methylated with their expression being repressed throughout differentiation. Since these genes are essential for V(DJ recombination of the T cell receptor (TCR locus, this indicates that nascent MAITs are kept from further rearrangement that may alter their antigen specificity. Importantly, we found that the repression of RAGs was assured in two layers: one by the modulation of transcription factors for RAGs, and the other by DNA methylation at the RAG loci. Together, our study provides a possible explanation for the unaltered antigen specificity in the selective differentiation of MAITs from iPSCs.

Mucosal-Associated Invariant T Cells: New Insights into Antigen Recognition and Activation

Directory of Open Access Journals (Sweden)

Xingxing Xiao

2017-11-01

Full Text Available Mucosal-associated invariant T (MAIT cells, a novel subpopulation of innate-like T cells that express an invariant T cell receptor (TCRα chain and a diverse TCRβ chain, can recognize a distinct set of small molecules, vitamin B metabolites, derived from some bacteria, fungi but not viruses, in the context of an evolutionarily conserved major histocompatibility complex-related molecule 1 (MR1. This implies that MAIT cells may play unique and important roles in host immunity. Although viral antigens are not recognized by this limited TCR repertoire, MAIT cells are known to be activated in a TCR-independent mechanism during some viral infections, such as hepatitis C virus and influenza virus. In this article, we will review recent works in MAIT cell antigen recognition, activation and the role MAIT cells may play in the process of bacterial and viral infections and pathogenesis of non-infectious diseases.

Mucosal-Associated Invariant T Cell Interactions with Commensal and Pathogenic Bacteria: Potential Role in Antimicrobial Immunity in the Child

Directory of Open Access Journals (Sweden)

Liana Ghazarian

2017-12-01

Full Text Available Mucosal-associated invariant T (MAIT cells are unconventional CD3+CD161high T lymphocytes that recognize vitamin B2 (riboflavin biosynthesis precursor derivatives presented by the MHC-I related protein, MR1. In humans, their T cell receptor is composed of a Vα7.2-Jα33/20/12 chain, combined with a restricted set of Vβ chains. MAIT cells are very abundant in the liver (up to 40% of resident T cells and in mucosal tissues, such as the lung and gut. In adult peripheral blood, they represent up to 10% of circulating T cells, whereas they are very few in cord blood. This large number of MAIT cells in the adult likely results from their gradual expansion with age following repeated encounters with riboflavin-producing microbes. Upon recognition of MR1 ligands, MAIT cells have the capacity to rapidly eliminate bacterially infected cells through the production of inflammatory cytokines (IFNγ, TNFα, and IL-17 and cytotoxic effector molecules (perforin and granzyme B. Thus, MAIT cells may play a crucial role in antimicrobial defense, in particular at mucosal sites. In addition, MAIT cells have been implicated in diseases of non-microbial etiology, including autoimmunity and other inflammatory diseases. Although their participation in various clinical settings has received increased attention in adults, data in children are scarce. Due to their innate-like characteristics, MAIT cells might be particularly important to control microbial infections in the young age, when long-term protective adaptive immunity is not fully developed. Herein, we review the data showing how MAIT cells may control microbial infections and how they discriminate pathogens from commensals, with a focus on models relevant for childhood infections.

Mucosa-associated invariant T cells in malignancies: a faithful friend or formidable foe?

Science.gov (United States)

Haeryfar, S M Mansour; Shaler, Christopher R; Rudak, Patrick T

2018-02-22

Mucosa-associated invariant T (MAIT) cells are a subset of innate-like T lymphocytes known for their ability to respond to MHC-related protein 1 (MR1)-restricted stimuli and select cytokine signals. They are abundant in humans and especially enriched in mucosal layers, common sites of neoplastic transformation. MAIT cells have been found within primary and metastatic tumors. However, whether they promote malignancy or contribute to anticancer immunity is unclear. On the one hand, MAIT cells produce IL-17A in certain locations and under certain circumstances, which could in turn facilitate neoangiogenesis, intratumoral accumulation of immunosuppressive cell populations, and cancer progression. On the other hand, they can express a potent arsenal of cytotoxic effector molecules, NKG2D and IFN-γ, all of which have established roles in cancer immune surveillance. In this review, we highlight MAIT cells' characteristics as they might pertain to cancer initiation, progression, or control. We discuss recent findings, including our own, that link MAIT cells to cancer, with a focus on colorectal carcinoma, as well as some of the outstanding questions in this active area of research. Finally, we provide a hypothetical picture in which MAIT cells constitute attractive targets in cancer immunotherapy.

Intra-Hepatic Depletion of Mucosal-Associated Invariant T Cells in Hepatitis C Virus-Induced Liver Inflammation.

Science.gov (United States)

Bolte, Fabian J; O'Keefe, Ashley C; Webb, Lauren M; Serti, Elisavet; Rivera, Elenita; Liang, T Jake; Ghany, Marc; Rehermann, Barbara

2017-11-01

Chronic hepatitis affects phenotypes of innate and adaptive immune cells. Mucosal-associated invariant T (MAIT) cells are enriched in the liver as compared with the blood, respond to intra-hepatic cytokines, and (via the semi-invariant T-cell receptor) to bacteria translocated from the gut. Little is known about the role of MAIT cells in livers of patients with chronic hepatitis C virus (HCV) infection and their fate after antiviral therapy. We collected blood samples from 42 patients with chronic HCV infection who achieved a sustained virologic response after 12 weeks of treatment with sofosbuvir and velpatasvir. Mononuclear cells were isolated from blood before treatment, at weeks 4 and 12 during treatment, and 24 weeks after the end of treatment. Liver biopsies were collected from 37 of the patients prior to and at week 4 of treatment. Mononuclear cells from 56 blood donors and 10 livers that were not suitable for transplantation were used as controls. Liver samples were assessed histologically for inflammation and fibrosis. Mononuclear cells from liver and blood were studied by flow cytometry and analyzed for responses to cytokine and bacterial stimulation. The frequency of MAIT cells among T cells was significantly lower in blood and liver samples of patients with HCV infection than of controls (median, 1.31% vs 2.32% for blood samples, P = .0048; and median, 4.34% vs 13.40% for liver samples, P = .001). There was an inverse correlation between the frequency of MAIT cells in the liver and histologically determined levels of liver inflammation (r = -.5437, P = .0006) and fibrosis (r = -.5829, P = .0002). MAIT cells from the liver had higher levels of activation and cytotoxicity than MAIT cells from blood (P liver inflammation and MAIT cell activation and cytotoxicity, and increased the MAIT cell frequency among intra-hepatic but not blood T cells. The MAIT cell response to T-cell receptor-mediated stimulation did not change during the 12 weeks of

Liiklusõnnetusi saab vältida / Jarno Habicht

Index Scriptorium Estoniae

Habicht, Jarno, 1976-

2004-01-01

Liiklusõnnetuste vältimisest. Samas vastavad küsimusele jalgrattateede ja nende ohutuse kohta Prussakovi-nimelise rattaühingu liider Erko Valk, Tallinna abilinnapea Jüri Ratas ja Eesti Jalgratturite Liidu president Siim Kallas

Ühe novelli lugu : subjektiivne kirjanduslooline etüüd / Aivar Kull

Index Scriptorium Estoniae

Kull, Aivar, 1955-

2015-01-01

Mait Metsanurga pikemast novellist "Dora Praats", mis ilmus 1943. a. vene keeles; avaldatud ka 16-osalise järjejutuna Toronto ajalehes "Vaba Eestlane" (8. veebr. - 2. aprill 1958) ning Mait Metsanurga novellikogumikus "Kreeps" (Tallinn : Eesti Raamat, 2005)

Navodnenija v umah zactroishtshikov / Maris Kuuda

Index Scriptorium Estoniae

Kuuda, Maris

2007-01-01

Kohalikel omavalitsustel pole piisavalt hoobasid sundida arendajaid üleujutusohuga arvestama. Pärnusse hotelli September rajajad (arhitektid Emil Urbel, Andrus Mark) arvestavad ujutusohuga. Arvamust avaldavad Rene Reisner, Mari Sepp, Ülo Sults, Karri Tiigisoon, Indrek Rannik, Mark Soosaar, Tiiu Pärn, Merle Looring, Rita Sepp, Kaspar Alles

Valik konkursi "Noored poeedid 2009" alapealkirjaga "See on rõõm elust endast" tunnustust pälvinud töödest : [luuletused

Index Scriptorium Estoniae

2009-01-01

Vanem vanuseaste 1. koht Triin Sepp, 2. koht Triinu Ansper, 3.-4. koht Kairi Sepp ja Heli Armus. Keskmine vanuseaste 1. koht Annaliis Lehto, 2. koht Liina Salonen, 3. koht Gerda-Liis Palmiste. Noorem vanuseaste 1. koht Reet Rüütel, 2. koht Diana Kasesalu, 3. koht Eliis Mets

Reflections on 35 years with Applied Optics: outgoing editorial.

Science.gov (United States)

Mait, Joseph N

2014-10-20

Applied Optics' Editor-in-Chief, Joseph N. Mait reflects on his experience as a reader, author, reviewer and eventual editor of the journal. Dr. Mait also introduces the incoming Editor-in-Chief, Ronald G. Driggers and acknowledges outgoing Division Editor, T.-C. Poon.

Controle de Cerconota anonella (Sepp. (Lep.: Oecophoridae e de Bephratelloides pomorum (Fab. (Hym.: Eurytomidae em frutos de pinha (Annona squamosa L.

Directory of Open Access Journals (Sweden)

Letice Souza da Silva

2014-01-01

Full Text Available A pinha, Annona squamosa L., é uma frutífera tropical da família anonácea, cujo mercado tem-se ampliado a cada ano, sendo cultivada expressivamente na região Nordeste, onde pequenos produtores a têm como principal fonte de renda. Entretanto, problemas causados pelas duas pragas-chave, Cerconota anonella (Sepp.,1830 (Lepidoptera: Oecophoridae e Bephratelloides pomorum (Fab.,1808 (Hymenoptera: Eurytomidae, têm limitado a produção e, consequentemente, a comercialização dos frutos. No intuito de minimizar essas perdas, um experimento de campo foi realizado em Maceió, Estado de Alagoas, Brasil, para avaliar diferentes formas de controle para estas pragas. O experimento foi conduzido no delineamento em blocos casualizados, com oito tratamentos e quatro repetições. Cada repetição correspondeu a quatro frutos, totalizando dezesseis frutos por tratamento. Os tratamentos foram: frutos sem proteção (testemunha; saco de papel branco impermeável aberto; saco plástico microperfurado; saco de TNT (tecido não tecido branco aberto; saco de TNT vermelho aberto; gaiola de arame revestida com tecido voile; inseticida Profenofós (12g/L-1 + Cipermetrina (1,2 g/L-1 e caulim (10 g/ 100 mL-1. Foram avaliadas as seguintes variáveis nos frutos: números de orifícios causados pelas pragas, peso, comprimento, diâmetro, percentagem de frutos colhidos e o custo do tratamento por unidade. Os melhores resultados foram obtidos com o saco de TNT vermelho aberto, obtendo-se 87,50% de frutos comercializáveis. O saco plástico microperfurado teve o menor custo, porém sua fragilidade impede a reutilização nas safras seguintes. Assim, indica-se o saco de TNT vermelho aberto como o mais econômico e eficiente.

Selenoprotein P Inhibits Radiation-Induced Late Reactive Oxygen Species Accumulation and Normal Cell Injury

Energy Technology Data Exchange (ETDEWEB)

Eckers, Jaimee C.; Kalen, Amanda L.; Xiao, Wusheng; Sarsour, Ehab H.; Goswami, Prabhat C., E-mail: prabhat-goswami@uiowa.edu

2013-11-01

Purpose: Radiation is a common mode of cancer therapy whose outcome is often limited because of normal tissue toxicity. We have shown previously that the accumulation of radiation-induced late reactive oxygen species (ROS) precedes cell death, suggesting that metabolic oxidative stress could regulate cellular radiation response. The purpose of this study was to investigate whether selenoprotein P (SEPP1), a major supplier of selenium to tissues and an antioxidant, regulates late ROS accumulation and toxicity in irradiated normal human fibroblasts (NHFs). Methods and Materials: Flow cytometry analysis of cell viability, cell cycle phase distribution, and dihydroethidium oxidation, along with clonogenic assays, were used to measure oxidative stress and toxicity. Human antioxidant mechanisms array and quantitative real-time polymerase chain reaction assays were used to measure gene expression during late ROS accumulation in irradiated NHFs. Sodium selenite addition and SEPP1 overexpression were used to determine the causality of SEPP1 regulating late ROS accumulation and toxicity in irradiated NHFs. Results: Irradiated NHFs showed late ROS accumulation (4.5-fold increase from control; P<.05) that occurs after activation of the cell cycle checkpoint pathways and precedes cell death. The mRNA levels of CuZn- and Mn-superoxide dismutase, catalase, peroxiredoxin 3, and thioredoxin reductase 1 increased approximately 2- to 3-fold, whereas mRNA levels of cold shock domain containing E1 and SEPP1 increased more than 6-fold (P<.05). The addition of sodium selenite before the radiation treatment suppressed toxicity (45%; P<.05). SEPP1 overexpression suppressed radiation-induced late ROS accumulation (35%; P<.05) and protected NHFs from radiation-induced toxicity (58%; P<.05). Conclusion: SEPP1 mitigates radiation-induced late ROS accumulation and normal cell injury.

Mõõdulindiga õnne ja edu kallal / Anneli Aasmäe

Index Scriptorium Estoniae

Aasmäe, Anneli, 1973-

2000-01-01

Juhtimiskonsultant Mait Raava kinnitusel on edukus 70 protsenti kaasasündinud omadus, Eesti edukatel on tegutsemisvajadus veres, nad võivad toetuda Iisraeli päritolu juhtimisteoreetiku Eliyahu M. Goldratti õpetusele, mitte eduretsepte ja õnnevalemeid pakkuvaile autorite rivile Dale Carnegie'st Ben Furmanini. Kommentaarid: Aune Past, Mait Raava

25 kaadrit sekundis / Liis Auväärt

Index Scriptorium Estoniae

Auväärt, Liis

2009-01-01

Nukufilmis käib töö filmiga "Lisa Limone & Maroc Orange", režissöör Mait Laas, animaatorid Triin Sarapik-Kivi, Märt Kivi, operaator Ragnar Neljandi, nukumeistrid Heigo Eeriksoo, Taivo Müürsep, Ene Mellow ja Kreeta Käeri. Dekoratsioonimeistrid Mait Erik ja Roman Kuznetsov

Study Paths, Riemann Surfaces, and Strebel Differentials

Science.gov (United States)

Buser, Peter; Semmler, Klaus-Dieter

2017-01-01

These pages aim to explain and interpret why the late Mika Seppälä, a conformal geometer, proposed to model student study behaviour using concepts from conformal geometry, such as Riemann surfaces and Strebel differentials. Over many years Mika Seppälä taught online calculus courses to students at Florida State University in the United States, as…

Fourth Generation War: Paradigm for Change

Science.gov (United States)

2005-06-01

PARADIGM FOR CHANGE by Ghanshyam Singh Katoch June 2005 Thesis Advisor : Kalev Sepp Second Reader...Approved by: Kalev Sepp Thesis Advisor Douglas Borer Second Reader Gordon McCormick Chairman, Department of Defense...combination of all the resources of the government, not just the army. d. Economy of Effort A Robo -Soldier is a small, tracked, electrically powered vehicle

Märt Agu: "Isa vari käib mul kogu aeg kannul" / Märt Agu ; interv. Aigi Viira

Index Scriptorium Estoniae

Agu, Märt

2006-01-01

1. okt. tähistas oma 30-aastast sünnipäeva ja oma ellukutsuja Mait Agu 55-sünniaastapäeva Tallinna Ülikooli koreograafiaosakond. Sel puhul esitati Estonias Mait Agu tantsulavastus "Kodalased ja kaasaegsed", mille seadis uuesti lavale Märt Agu oma isa loodud koreograafia põhjal

Ja mul oli veel nii palju öelda! / Marju Kõivupuu

Index Scriptorium Estoniae

Kõivupuu, Marju, 1960-

2006-01-01

Ka järgmistest raamatutest: Schultz-Bertram, Georg Julius. Balti idealisti kirjad emale / tlk. Ilmar Vene. Tartu : Ilmamaa, 2003 ; Dr. Bertram. Tartu tudengid viiskümmend aastat tagasi / saksa keelest Viktor Sepp. Tallinn : Perioodika, 1999. (Loomingu Raamatukogu ; 17) ; Pärnik, Ylo M. Dr Georg Julius von Schultz-Bertram. Tartu : Ilmamaa, 2006 ; Dr. Bertram. Kolm Tartu balli / tlk. Viktor Sepp. Tallinn : Perioodika, 1990. (Loomingu Raamatukogu ; 26)

Serum selenium and selenoprotein-P levels in autoimmune thyroid diseases patients in a select center: a transversal study.

Science.gov (United States)

Federige, Marco Aurélio Ferreira; Romaldini, João Hamilton; Miklos, Ana Beatriz Pinotti Pedro; Koike, Marcia Kiyomi; Takei, Kioko; Portes, Evandro de Souza

2017-12-01

Selenium (Se) supplementation has been used to help prevent the progression of Graves' ophthalmopathy (GO) and autoimmune thyroid diseases (AITD) patients. We investigated Se serum and selenoprotein P (SePP) levels in Graves' disease (GD) with and without GO, Hashimoto's thyroiditis (HT) patients and in 27 control individuals (C). We studied 54 female and 19 male patients: 19 with GD without GO, 21 GD with GO, 14 with HT and 19 with HT+LT4. Se values were measured using graphite furnace atomic absorption spectrophotometry. Serum SePP levels were measured by ELISA. Median Se levels were similar among all groups; GD patients: 54.2 (46.5-61.1 μg/L), GO: 53.6 (43.5-60.0 μg/L), HT: 51.9 (44.6-58.5 μg/L), HT+LT4 54.4 (44-63.4) and C group patients: 56.0 (52.4-61.5 μg/L); P = 0.48. However, serum SePP was lower in GO patients: 0.30 (0.15-1.05 μg/mL) and in HT patients: 0.35 (0.2-1.17 μg/mL) compared to C group patients: 1.00 (0.564.21 μg/mL) as well as to GD patients: 1.19 (0.62-2.5 μg/mL) and HT+LT4 patients: 0.7 (0,25-1.95); P = 0.002. Linear regression analysis showed a significant relationship between SePP and TPOAb values (r = 0.445, R2 = 0.293; P < 0.0001). Multiple regression analysis found no independent variables related to Se or SePP. A serum Se concentration was lower than in some other countries, but not significantly among AITD patients. The low serum SePP levels in GO and HT patients seems to express inflammatory reactions with a subsequent increase in Se-dependent protein consumption remains unclear.

Stochastic energy procurement of large electricity consumer considering photovoltaic, wind-turbine, micro-turbines, energy storage system in the presence of demand response program

International Nuclear Information System (INIS)

Nojavan, Sayyad; Aalami, Habib allah

2015-01-01

Highlights: • A stochastic energy procurement cost function in presence of DRP is proposed. • The load, price and output power of PV and wind uncertainties are modeled. • Four case studies are used to assess the effects of ESS and DRP on SEPP. • Case 4 is considered the effects of ESS and DRP simultaneously. • The expected energy procurement cost of case 4 is lower than cases 1, 2 and 3. - Abstract: This paper proposes a stochastic energy procurement problem (SEPP) for large electricity consumer (LEC) with multiple energy procurement sources (EPSs) considering the effects of demand response program (DRP) and energy storage system (ESS). The EPSs contain power market (PM), bilateral contracts (BCs), micro-turbines (MTs), and renewable energy sources (RESs). Moreover, the RESs include photovoltaic (PV) systems and wind-turbines (WT). The ESS and DRP are incorporated in the SEPP by the LEC’s decision-maker to reduce the expected energy procurement cost (EEPC). Meanwhile, the uncertainty models of market price, load and RES output power are considered in the SEPP formulation. The error of forecasting of market price, load, temperature and radiation of PV systems are modeled using the normal distribution for generating the related scenarios. Also, the weibull distribution is used to generate variable wind speed scenarios for WT output power uncertainty modeling. Furthermore, the fast forward selection based on Kantorovich distance approach is used for the scenarios reduction. Finally, the influences of ESS and DRP on EEPC are investigated, and four case studies are used to illustrate the capability of the proposed SEPP. The obtained results demonstrate the efficiency of the proposed stochastic program

Eesti Vabariigiga ühevanused memmed kirjutavad presidendile / Rein Sikk

Index Scriptorium Estoniae

Sikk, Rein

2007-01-01

Neli memme, kes on sündinud 1918. a. veebruaris, Eesti Vabariigiga ühel ajal, kirjutavad ajakirjaniku vahendusel presidendile. Vt. samas: Alide Sepp: ehk saate päästa meie hooldekodu; Meeta Hütt: kaege perra, et elu oles rahulik; Milli Rump: andke pidustuste raha hoopis vaeslastele; Helmi Kõrnas: mõelge alati hästi. Sõna saavad Alide Sepp ja Helmi Kõrnas Pärnust, Meeta Hütt Võrust ja Milli Rump Väike-Maarjast

Üleujutus arendaja hingel / Maris Kuuda

Index Scriptorium Estoniae

Kuuda, Maris

2007-01-01

Kohalikel omavalitsustel pole piisavalt hoobasid sundida arendajaid üleujutusohuga arvestama. Pärnusse hotelli September rajajad (arhitektid Emil Urbel, Andrus Mark) arvestavad ujutusohuga. Arvamust avaldavad Rene Reisner, Mari Sepp, Ülo Sults, Karri Tiigisoon, Indrek Rannik, Mark Soosaar, Tiiu Pärn, Merle Looring, Rita Sepp, Kaspar Alles. Keskkonnaministeeriumi plaanist muuta veeseadust, mis sunniks ehitajaid ja arendajaid arvestama üleujutusohuga. Lisadena olulise üleujutusohuga alad Eestis ning üleujutuste ohjamist käsitleva Euroopa Liidu direktiivi eelnõust

Tallinna võim on libastumine?

Index Scriptorium Estoniae

2005-01-01

Elmar Sepp ja Tõnis Palts vastavad küsimusele, mis puudutab Taavi Veskimäe väidet, et Res Publica koostöö Tallinnas on Res Publica suurima poliitilise libastumise tagajärg. Elmar Sepp ei välista sügisestel valimistel Keskerakonna ja Res Publica koostöö jätkumist Tallinnas, tema sõnul ei ole Keskerakond mitte totalitaarne, vaid Eesti üks demokraatlikumaid erakondi. Vt. samas: Katkend Taavi Veskimäe kõnest Res Publica üldkogul

Unique and Common Features of Innate-Like Human Vδ2+ γδT Cells and Mucosal-Associated Invariant T Cells

Directory of Open Access Journals (Sweden)

Nicholas M. Provine

2018-04-01

Full Text Available Mucosal-associated invariant T (MAIT cells are innate-like T cells abundant in humans that can be activated in a TCR-independent manner by inflammatory and antiviral cytokines. In humans, the capacity for TCR-independent activation is functionally linked to a transcriptional program that can be identified by the expression of the C-type lectin receptor, CD161. In addition to MAIT cells, it has been demonstrated that a subset of γδT cells expresses CD161 and can be activated by TCR-independent cytokine stimulation. In this study, we sought to clarify the nature of cytokine-responsive human γδT cells. We could link CD161 expression on Vδ2+ versus Vδ1+ γδT cells to the observation that Vδ2+ γδT cells, but not Vδ1+ γδT cells, robustly produced IFN-γ upon stimulation with a variety of cytokine combinations. Interestingly, both CD161+ and CD161− Vδ2+ γδT cells responded to these stimuli, with increased functionality within the CD161+ subset. This innate-like responsiveness corresponded to high expression of PLZF and IL-18Rα, analogous to MAIT cells. Vδ2+ γδT cells in human duodenum and liver maintained a CD161+ IL-18Rα+ phenotype and produced IFN-γ in response to IL-12 and IL-18 stimulation. In contrast to MAIT cells, we could not detect IL-17A production but observed higher steady-state expression of Granzyme B by Vδ2+ γδT cells. Finally, we investigated the frequency and functionality of γδT cells in the context of chronic hepatitis C virus infection, as MAIT cells are reduced in frequency in this disease. By contrast, Vδ2+ γδT cells were maintained in frequency and displayed unimpaired IFN-γ production in response to cytokine stimulation. In sum, human Vδ2+ γδT cells are a functionally distinct population of cytokine-responsive innate-like T cells that is abundant in blood and tissues with similarities to human MAIT cells.

Challenge of Humans with Wild-type Salmonella enterica Serovar Typhi Elicits Changes in the Activation and Homing Characteristics of Mucosal-Associated Invariant T Cells

OpenAIRE

Salerno-Goncalves, Ros?ngela; Luo, David; Fresnay, Stephanie; Magder, Laurence; Darton, Thomas C.; Jones, Claire; Waddington, Claire S.; Blohmke, Christoph J.; Angus, Brian; Levine, Myron M.; Pollard, Andrew J.; Sztein, Marcelo B.

2017-01-01

Gastrointestinal infections by Salmonella enterica serovar Typhi (S. Typhi) are rare in industrialized countries. However, they remain a major public health problem in the developing world with an estimated 26.9 million new cases annually and significant mortality when untreated. Recently, we provided the first direct evidence that CD8(+) MAIT cells are activated and have the potential to kill cells exposed to S. Typhi, and that these responses are dependent on bacterial load. However, MAIT c...

Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma.

Science.gov (United States)

Ishimori, Ayako; Harada, Norihiro; Chiba, Asako; Harada, Sonoko; Matsuno, Kei; Makino, Fumihiko; Ito, Jun; Ohta, Shoichiro; Ono, Junya; Atsuta, Ryo; Izuhara, Kenji; Takahashi, Kazuhisa; Miyake, Sachiko

2017-04-01

A variety of innate subsets of lymphoid cells such as natural killer (NK) cells, several populations of innate lymphoid cells (ILCs), and mucosal-associated invariant T (MAIT) cells as innate-like T lymphocytes are involved in asthma and may have important effector functions in asthmatic immune responses. In the present study, we investigated whether NK cells, ILCs, and MAIT cells in the peripheral blood of patients with asthma would be associated with clinical asthma parameters. We recruited 75 adult patients with mild to severe asthma. The peripheral blood mononuclear cells in peripheral venous blood samples from the patients were purified and stained with different combinations of appropriate antibodies. The cells were analyzed by flow cytometry. The percentage of activated (i.e., CD69 + ) NK cells in the total NK cell population was negatively correlated with FEV 1 % which is calculated by the forced expiratory volume in 1 s (FEV 1 )/the forced vital capacity (FVC). The percentages of CD69 + ILC1s and ILC2s were negatively correlated with FEV 1 % and %FEV 1 . The percentage of CD69 + ILC3s was positively correlated with BMI, and the percentage of CD69 + MAIT cells was negatively correlated with FEV 1 %. Moreover, the percentage of CD69 + NK cells, ILC1s, ILC2s, ILC3s, and MAIT cells were positively correlated with each other. For the first time, our data showed that activated NK cells, ILC1s, ILC2s, ILC3s, and MAIT cells were positively correlated with each other and may be associated with airflow limitation in patients with asthma. Copyright © 2016 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved.

Plaadid / Mait Eelrand

Index Scriptorium Estoniae

Eelrand, Mait, 1950-

2006-01-01

Uutest heliplaatidest JJ CAle & Eric Clapton "The Road To escondido", Fergie "The Dutchess", Cosmoskva "Juniper", "The Devil Wears Prada", Peaches "Impeach My Bush", Ludacris "Release Therapy", Milburn "Well Well Well"

Plasma Selenium Biomarkers in Low Income Black and White Americans from the Southeastern United States

Science.gov (United States)

Hargreaves, Margaret K.; Liu, Jianguo; Buchowski, Maciej S.; Patel, Kushal A.; Larson, Celia O.; Schlundt, David G.; Kenerson, Donna M.; Hill, Kristina E.; Burk, Raymond F.; Blot, William J.

2014-01-01

Biomarkers of selenium are necessary for assessing selenium status in humans, since soil variation hinders estimation of selenium intake from foods. In this study, we measured the concentration of plasma selenium, selenoprotein P (SEPP1), and glutathione peroxidase (GPX3) activity and their interindividual differences in 383 low-income blacks and whites selected from a stratified random sample of adults aged 40–79 years, who were participating in a long-term cohort study in the southeastern United States (US). We assessed the utility of these biomarkers to determine differences in selenium status and their association with demographic, socio-economic, dietary, and other indicators. Dietary selenium intake was assessed using a validated food frequency questionnaire designed for the cohort, matched with region-specific food selenium content, and compared with the US Recommended Dietary Allowances (RDA) set at 55 µg/day. We found that SEPP1, a sensitive biomarker of selenium nutritional status, was significantly lower among blacks than whites (mean 4.4±1.1 vs. 4.7±1.0 mg/L, p = 0.006), with blacks less than half as likely to have highest vs. lowest quartile SEPP1 concentration (Odds Ratio (OR) 0.4, 95% Confidence Interval (CI) 0.2–0.8). The trend in a similar direction was observed for plasma selenium among blacks and whites, (mean 115±15.1 vs. 118±17.7 µg/L, p = 0.08), while GPX3 activity did not differ between blacks and whites (136±33.3 vs. 132±33.5 U/L, p = 0.320). Levels of the three biomarkers were not correlated with estimated dietary selenium intake, except for SEPP1 among 10% of participants with the lowest selenium intake (≤57 µg/day). The findings suggest that SEPP1 may be an effective biomarker of selenium status and disease risk in adults and that low selenium status may disproportionately affect black and white cohort participants. PMID:24465457

Determinants of selenium status in healthy adults

Directory of Open Access Journals (Sweden)

Hoeg Antonia

2011-07-01

Full Text Available Abstract Background Selenium (Se status in non-deficient subjects is typically assessed by the Se contents of plasma/serum. That pool comprises two functional, specific selenoprotein components and at least one non-functional, non-specific components which respond differently to changes in Se intake. A more informative means of characterizing Se status in non-deficient individuals is needed. Methods Multiple biomarkers of Se status (plasma Se, serum selenoprotein P [SEPP1], plasma glutathione peroxidase activity [GPX3], buccal cell Se, urinary Se were evaluated in relation to selenoprotein genotypes (GPX1, GPX3, SEPP1, SEP15, dietary Se intake, and parameters of single-carbon metabolism in a cohort of healthy, non-Se-deficient men (n = 106 and women (n = 155. Conclusions Plasma Se concentration was 142.0 ± 23.5 ng/ml, with GPX3 and serum-derived SEPP1 calculated to comprise 20% and 34%, respectively, of that total. The balance, comprised of non-specific components, accounted for virtually all of the interindividual variation in total plasma Se. Buccal cell Se was associated with age and plasma homocysteine (hCys, but not plasma Se. SEPP1 showed a quadratic relationship with body mass index, peaking at BMI 25-30. Urinary Se was greater in women than men, and was associated with metabolic body weight (kg0.75, plasma folate, vitamin B12 and hCys (negatively. One GPX1 genotype (679T/T was associated with significantly lower plasma Se levels than other allelic variants. Selenium intake, estimated from food frequency questionnaires, did not predict Se status as indicated by any biomarker. These results show that genotype, methyl-group status and BMI contribute to variation in Se biomarkers in Se-adequate individuals.

Mucosal-associated invariant T cell is a potential marker to distinguish fibromyalgia syndrome from arthritis.

Directory of Open Access Journals (Sweden)

Chie Sugimoto

Full Text Available Fibromyalgia (FM is defined as a widely distributed pain. While many rheumatologists and pain physicians have considered it to be a pain disorder, psychiatry, psychology, and general medicine have deemed it to be a syndrome (FMS or psychosomatic disorder. The lack of concrete structural and/or pathological evidence has made patients suffer prejudice that FMS is a medically unexplained symptom, implying inauthenticity. Furthermore, FMS often exhibits comorbidity with rheumatoid arthritis (RA or spondyloarthritis (SpA, both of which show similar indications. In this study, disease specific biomarkers were sought in blood samples from patients to facilitate objective diagnoses of FMS, and distinguish it from RA and SpA.Peripheral blood mononuclear cells (PBMCs from patients and healthy donors (HD were subjected to multicolor flow cytometric analysis. The percentage of mucosal-associated invariant T (MAIT cells in PBMCs and the mean fluorescent intensity (MFI of cell surface antigen expression in MAIT cells were analyzed.There was a decrease in the MAIT cell population in FMS, RA, and SpA compared with HD. Among the cell surface antigens in MAIT cells, three chemokine receptors, CCR4, CCR7, and CXCR1, a natural killer (NK receptor, NKp80, a signaling lymphocyte associated molecule (SLAM family, CD150, a degrunulation marker, CD107a, and a coreceptor, CD8β emerged as potential biomarkers for FMS to distinguish from HD. Additionally, a memory marker, CD44 and an inflammatory chemokine receptor, CXCR1 appeared possible markers for RA, while a homeostatic chemokine receptor, CXCR4 deserved for SpA to differentiate from FMS. Furthermore, the drug treatment interruption resulted in alternation of the expression of CCR4, CCR5, CXCR4, CD27, CD28, inducible costimulatory molecule (ICOS, CD127 (IL-7 receptor α, CD94, NKp80, an activation marker, CD69, an integrin family member, CD49d, and a dipeptidase, CD26, in FMS.Combined with the currently available

Mucosal-associated invariant T cell is a potential marker to distinguish fibromyalgia syndrome from arthritis.

Science.gov (United States)

Sugimoto, Chie; Konno, Takahiko; Wakao, Rika; Fujita, Hiroko; Fujita, Hiroyoshi; Wakao, Hiroshi

2015-01-01

Fibromyalgia (FM) is defined as a widely distributed pain. While many rheumatologists and pain physicians have considered it to be a pain disorder, psychiatry, psychology, and general medicine have deemed it to be a syndrome (FMS) or psychosomatic disorder. The lack of concrete structural and/or pathological evidence has made patients suffer prejudice that FMS is a medically unexplained symptom, implying inauthenticity. Furthermore, FMS often exhibits comorbidity with rheumatoid arthritis (RA) or spondyloarthritis (SpA), both of which show similar indications. In this study, disease specific biomarkers were sought in blood samples from patients to facilitate objective diagnoses of FMS, and distinguish it from RA and SpA. Peripheral blood mononuclear cells (PBMCs) from patients and healthy donors (HD) were subjected to multicolor flow cytometric analysis. The percentage of mucosal-associated invariant T (MAIT) cells in PBMCs and the mean fluorescent intensity (MFI) of cell surface antigen expression in MAIT cells were analyzed. There was a decrease in the MAIT cell population in FMS, RA, and SpA compared with HD. Among the cell surface antigens in MAIT cells, three chemokine receptors, CCR4, CCR7, and CXCR1, a natural killer (NK) receptor, NKp80, a signaling lymphocyte associated molecule (SLAM) family, CD150, a degrunulation marker, CD107a, and a coreceptor, CD8β emerged as potential biomarkers for FMS to distinguish from HD. Additionally, a memory marker, CD44 and an inflammatory chemokine receptor, CXCR1 appeared possible markers for RA, while a homeostatic chemokine receptor, CXCR4 deserved for SpA to differentiate from FMS. Furthermore, the drug treatment interruption resulted in alternation of the expression of CCR4, CCR5, CXCR4, CD27, CD28, inducible costimulatory molecule (ICOS), CD127 (IL-7 receptor α), CD94, NKp80, an activation marker, CD69, an integrin family member, CD49d, and a dipeptidase, CD26, in FMS. Combined with the currently available

Tõuloom 2012 / Krista Sepp

Index Scriptorium Estoniae

Sepp, Krista

2012-01-01

Eesti Tõuloomakasvatuse Liidu poolt Ülenurme Põllumajandusmuuseumis 1. septembril korraldatud tõuloomade konkursil Tartu sügisnäitus. Tõuloom 2012 tunnustatud Eesti Hobusekasvatajate Seltsi liikmetest ning trakeeni, araabia tori, eesti ja eesti raskeveo tõugu hobustest

Eesti nimekaim ilukirurg jagab enesekindlust / Peep Pree ; intevjueerinud Priit Pullerits

Index Scriptorium Estoniae

Pree, Peep, 1958-

2006-01-01

Vestlus Tartu esteetilise kirurgia erakliiniku Clinica juhatajaga tööst, vastutustundest, ebaõnnestumistest. Kommenteerivad Tartu linnapea Laine Jänes ja Tartu Ülikooli arstiteaduskonna emeriitprofessor Ennu Sepp

Pink Pungi näitusel valgub veri linale / Raimu Hanson

Index Scriptorium Estoniae

Hanson, Raimu, 1957-

2006-01-01

Kunstirühmituse Pink Punk (Sandra Jõgeva, Kristin Kalamees, Aino Ingrid Sepp, Kaarel Sammet) näitusest Y-galeriis. Lähemalt videoinstallatsioonist "Must turg" ja ruumiinstallatsioonist "Elulähedane kogemus"

Kabja tervishoiu koolitus / Sanna Turu

Index Scriptorium Estoniae

Turu, Sanna

2013-01-01

Eesti Raskeveohobuse Seltsi poolt 25. mail Raplamaal Piibelehe Puhkekemajas korraldatud koolitusest, kus hobuveterinaar Triin Tohver ja professionaalne sepp Stephan Ernest Saksamaalt tegid põhjaliku ülevaate hobuse kabja tervishoiu teemadel

What Intellectual Property lawyers can Learn from Barbra Streisand ...

African Journals Online (AJOL)

... lawyers can Learn from Barbra Streisand, Sepp Blatter, and the "Coca-Cola ... rights; Overly-aggressive enforcement; Rights holder over-reach; Litigation strategy; ... 'Trademark extortion'; 'Duty to police'; Streisand effect; Ambush marketing.

"Upgraded" physics at the LHC and RHIC

Energy Technology Data Exchange (ETDEWEB)

Llope, W. J. [Wayne State University, Detroit, MI (United States)

2017-09-03

Closeout materials enclosed. This grant supported a postdoctoral scientist (S. Jowzaee) and the tuition for a graduate student (B. Erko), both working under the supervision of Prof. W.J. Llope at Wayne State University. Travel to a STAR Collaboration Meeting and the Quark Matter 2017 conference was also supported. The physics research concentrated on particle-identified two-particle correlations in the Beam Energy Scan data from the STAR experiment at RHIC. S. Jowzaee gave an oral presentation on this research at the Quark Matter 2017 conference.

Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua Basalis

Directory of Open Access Journals (Sweden)

Martin Solders

2017-01-01

Full Text Available The maternal part of the placenta, the decidua, consists of maternal immune cells, decidual stromal cells, and extravillous fetal trophoblasts. In a successful pregnancy, these cell compartments interact to provide an intricate balance between fetal tolerance and antimicrobial defense. These processes are still poorly characterized in the two anatomically different decidual tissues, basalis and parietalis. We examined immune cells from decidua basalis and parietalis from term placentas (n=15 with flow cytometry. By using multivariate discriminant analysis, we found a clear separation between the two decidual compartments based on the 81 investigated parameters. Decidua parietalis lymphocytes displayed a more activated phenotype with a higher expression of coinhibitory markers than those isolated from basalis and contained higher frequencies of T regulatory cells. Decidua basalis contained higher proportions of monocytes, B cells, and mucosal-associated invariant T (MAIT cells. The basalis B cells were more immature, and parietalis MAIT cells showed a more activated phenotype. Conventional T cells, NK cells, and MAIT cells from both compartments potently responded with the production of interferon-γ and/or cytotoxic molecules in response to stimulation. To conclude, leukocytes in decidua basalis and parietalis displayed remarkable phenotypic disparities, indicating that the corresponding stromal microenvironments provide different immunoregulatory signals.

Riho Pätsi koolimuusika fond tunnustab parimaid / Inge Raudsepp

Index Scriptorium Estoniae

Raudsepp, Inge, 1951-

2015-01-01

Riho Pätsi Koolimuusika Fond on üks Tallinna Ülikooli fondidest. Tänavused laureaadid on muusikaõpetaja Kadi Härma, klaveripedagoog Liina Jarovaja, helilooja Juhan Trump ning muusikapedagoogika uurija Anu Sepp

Mida sportijad vajavad? / Evelin Kivilo-Paas

Index Scriptorium Estoniae

Kivilo-Paas, Evelin, 1979-

2015-01-01

Sportijate toitainete vajaduse kohta jagavad selgitusi Tallinna Ülikooli terviseteaduste ja spordi instituudi direktor ja spordibioloog Kristjan Port, Synlab Eesti laboriarst dr Anneli Raave-Sepp ja Spordimeditsiini SA spordiarst dr Krista Veevo

Mentorklubi süstib väikeettevõtjale tegutsemiskindlust / Teeli Remmelg

Index Scriptorium Estoniae

Remmelg, Teeli

2005-01-01

Tallinna Mentorklubi tegevusest, kus väikeettevõtjad õpivad üksteise vigadest ja õnnestumistest. Kommenteerivad EASi mentorprogrammi koordinaator Liina Võrkaed ja Pro Konsultatsioonid, Tallinna Mentorklubi mentor Mait Raava

Leningradi aktsioonid / Sandra Jõgeva

Index Scriptorium Estoniae

Jõgeva, Sandra, 1976-

2006-01-01

Eesti kunstnike väljapanekust "Empty Spaces and their Occupants" 12.-24. augustini 2006 a. toimuval Peterburi Maneezhi 6. rahvusvahelisel eksperimentaalkunsti festivalil, kuraator Maksim Surin. Osalevad Kaido Ole, Merike Estna, Meeland Sepp jt

Arvuti ja tema kuju / Tõnu Kaalep

Index Scriptorium Estoniae

Kaalep, Tõnu, 1966-2018

2000-01-01

Disain on jõudnud arvutiteni. Arvutite iMac, iBook, Macintosh, Microlingi Cosmic Flex ATX jt. disainist. Disainer M. Pärn arvutite ja disaini suhetest, M. Sepp ostjate reageerimisest Cosmic Flex ATX disainile.

Eesti Linnade Liidu, Eesti Omavalitsusliitude Ühenduse, Eesti Korteriühistute Liidu ja Eesti Gaasiliidu pöördumine = Obrashtshenije k Sojuzu Gorodov Estonii, Obedineniju Samoupravlenii Estonii, Sojuzu Kvartirnõhh Tovarishtshestv Estonii i Sojuzu

Index Scriptorium Estoniae

2003-01-01

Pöördumises tehakse valitsusele ettepanek kavandada kodugaasiseadmete väljavahetamise projekt koos finantseerimise kavaga. Pöördumisele on alla kirjutanud Jaanus Tamkivi, Toomas Välimäe, Marit Otsing ja Allan Sepp

Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett's esophagus: results from biomarkers and genetic variants.

Directory of Open Access Journals (Sweden)

Yumie Takata

Full Text Available Clinical trials have suggested a protective effect of selenium supplementation on the risk of esophageal cancer, which may be mediated through the antioxidant activity of selenoenzymes. We investigated whether serum selenium concentrations, selenoenzyme activity, oxidative stress and genetic variation in selenoenzymes were associated with the risk of neoplastic progression to esophageal adenocarcinoma (EA and two intermediate endpoints, aneuploidy and tetraploidy. In this prospective cohort study, during an average follow-up of 7.3 years, 47 EA cases, 41 aneuploidy cases and 51 tetraploidy cases accrued among 361 participants from the Seattle Barrett's Esophagus Research Study who were free of EA at the time of blood draw and had at least one follow-up visit. Development to EA was assessed histologically and aneuploidy and tetraploidy by DNA content flow cytometry. Serum selenium concentrations were measured using atomic absorption spectrometry, activity of glutathione peroxidase (GPX 1 and GPX3 by substrate-specific coupled test procedures, selenoprotein P (SEPP1 concentrations and protein carbonyl content by ELISA method and malondialdehyde concentrations by HPLC. Genetic variants in GPX1-4 and SEPP1 were genotyped. Serum selenium was not associated with the risk of neoplastic progression to EA, aneuploidy or tetraploidy (P for trend = 0.25 to 0.85. SEPP1 concentrations were positively associated with the risk of EA [hazard ratio (HR = 3.95, 95% confidence intervals (CI = 1.42-10.97 comparing the third tertile with the first] and with aneuploidy (HR = 6.53, 95% CI = 1.31-32.58, but not selenoenzyme activity or oxidative stress markers. No genetic variants, overall, were associated with the risk of neoplastic progression to EA (global p = 0.12-0.69. Our results do not support a protective effect of selenium on risk of neoplastic progression to EA. Our study is the first to report positive associations of plasma SEPP1

K. Linda Kivi autoriõhtu Tartu College´is / Eda Sepp ; fotod: Eda Sepp

Index Scriptorium Estoniae

Sepp, Eda

2006-01-01

19. jaanuaril 2006, Linda Kivi kolmanda raamatu "The Inner Green: Exploring Home in the Columbia Mountains" raamatuesitlusest. Korraldajateks Toronto Ülikooli Eesti Õppetool, Tartu Instituut, Tartu College´i laenuraamatukogu

Snegurotshkad, plast ja punalipud ERKI moeshõul / Triin Thalheim

Index Scriptorium Estoniae

Thalheim, Triin, 1982-

2005-01-01

Sõna ja pildiga tutvustatakse Vene Kultuurikeskuses ERKI moeshõul esitatud Vassilissa, Kirill Safonovi, Kati Ilvese, Anna Roometi, Marte Kisandi, Pille Jürisoo, Karen Milistveri, Piret Paali, Erikka Bahnseni, Mikko Seppä, Hao Zhangi kollektsioone

Eesti elektrisüsteemi juhtimiskeskus = Estonian electrical system command centre

Index Scriptorium Estoniae

2010-01-01

Tallinnas Kadaka tee 42B1asuva Eesti elektrisüsteemi juhtimiskeskuse sisekujundusest. Spetsiaalsed kaarjad lauad on sisearhitektide projekteeritud. Sisearhitektid: Priit Põldme, Reet Sepp (Joonprojekt), nende tähtsamate tööde loetelu

"Nägemus" EKA galeriis

Index Scriptorium Estoniae

2003-01-01

Tartu Kõrgema Kunstikooli tekstiilikunsti osakonna gobeläänide näitus "Nägemus". Osalejad: Triinu Pungits, Signe Vilde, Jaanika Terasmaa, Leeda Ots, Gerli Aimla, Merike Uiga, Irina Vizner-Laur, Mari Vaaderpall, Heike Sepp

Louis Blajan, Dottore in Medicina Veterinaria: Il dinamico veterinario che seppe traghettare l’Organizzazione Mondiale per la Sanità Animale (Office International des Épizooties: OIE nel mondo moderno

Directory of Open Access Journals (Sweden)

Anon.

2010-03-01

Full Text Available Nato il 10 aprile 1924 a Lahage (nell’Alta Garonna, in Francia, Louis Blajan si è spento lo scorso 10 febbraio 2010 a Mont-de-Marsan.Dopo aver frequentato il Lycée Pierre de Fermat di Tolosa, nel 1948 Louis completa gli studi presso la Scuola di Veterinaria di Tolosa. Nel 1949, si diploma all’Institut d’élevage et de médecine vétérinaire des pays tropicaux (IEMVT e dal 1949 al 1952 è nel territorio d’oltremare francese del Mali. Tornato in Francia, dal 1953 al 1968 Louis esercita come veterinario di Stato presso il Ministero dell’Agricoltura, responsabile per l’afta epizootica, la peste suina e la malattia di Newcastle, nonché come Presidente del Comitato consultivo per le malattie infettive. In seguito, viene nominato Ispettore capo veterinario e Responsabile per la politica di controllo delle frontiere.Nel 1952, Louis sposa Janine, moglie affezionata che lo appoggia con ardore in ogni fase della sua carriera e perde la vita in un incidente un mese prima che il marito vada in pensione nel 1990.Dal 1968 al 1977, Louis è Direttore tecnico di Cofranimex (Compagnie Française pour l’importation et l’exportation des animaux reproducteurs et leur semence e dal 1977 al 1978 riveste il ruolo di Direttore dell’Association pour le développement des techniques de l’élevage français (ADETEF.Louis entra a lavorare nell’Office International des Épizooties (oggi noto come Organizzazione Mondiale per la Sanità Animale o ‘OIE’ dove, dal 1978 al 1980, occupa la posizione di Direttore del Dipartimento tecnico. Due anni più tardi, nel 1980, viene eletto Direttore Generale, coronando il sogno di ogni professionista della medicina veterinaria e raggiungendo l’apice della propria carriera. Rieletto nel 1985, si ritira dalla vita lavorativa nel 1990.Durante gli anni in cui fu a capo dell’OIE, Louis seppe trasformare quella che all’epoca era una struttura antiquata in un’organizzazione internazionale moderna ed

Euroopa Liidu IT-agentuur / Katrin Koov

Index Scriptorium Estoniae

Koov, Katrin, 1973-

2015-01-01

Arhitektuurivõistluse eesmärk oli leida Euroopa Liidu IT-agentuuri peahoone rajamiseks Vesilennuki tänavale Tallinnas parim arhitektuuriline lahendus. Esitati 15 ideekavandit, millest kvalfitseerusid 14. Esimese koha sai töö märgusõnaga "Turing" (autorid: Jaan Kuusemets, Üllar Ambos, Pille Noole, Ioannis Lykouras, Erko Luhaaru, DAGOpen ja LÜNK Arhitektid). Teisele kohale tuli töö märgusõnaga "Platoo" (autor Karli Luik, AB Kontekst). Kolmandale kohale tuli töö märgusõnaga "Bastion" (autorid: Ralf Lõoke, Maarja Kask, Martin McLean, Salto AB).

Kaebus sunnib teatreid suitsetamise osas aru pidama

Index Scriptorium Estoniae

2009-01-01

Draamateatri külastaja kaebuse peale - etenduses "Pedro Páramo" suitsetas näitleja Mait Malmsten kogu esimese vaatuse - arutab Eesti Etendusasutuste Liit peagi laval suitsetamisega seotud küsimusi

Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus.

Directory of Open Access Journals (Sweden)

Stoyan Ivanov

2014-10-01

Full Text Available Non-conventional T lymphocytes constitute a special arm of the immune system and act as sentinels against pathogens at mucosal surfaces. These non-conventional T cells (including mucosal-associated invariant T [MAIT] cells, gamma delta [γδ] T cells, and natural killer T [NKT] cells display several innate cell-like features and are rapidly activated by the recognition of conserved, stress-induced, self, and microbial ligands. Here, we review the role of non-conventional T cells during respiratory infections, with a particular focus on the encapsulated extracellular pathogen Streptococcus pneumoniae, the leading cause of bacterial pneumonia worldwide. We consider whether MAIT cells, γδ T cells, and NKT cells might offer opportunities for preventing and/or treating human pneumococcus infections.

Маленьким кинотеатрам грозит закрытие / Ханнели Руди

Index Scriptorium Estoniae

Руди, Ханнели

2011-01-01

Üha enam levib maailmas DCP (Digital Cinema Package) ehk filmi digiteeritud salvestis. Eestis on vaid Tallinna ja Tartu kinodes tehnika, millega vaadata DCP filme. Probleemi analüüsib Kultuuriministeeriumi filminõunik Edit Sepp

Peaminister Parts : lapsed olgu meist targemad / Juhan Parts ; interv. Toomas Sildam

Index Scriptorium Estoniae

Parts, Juhan, 1966-

2003-01-01

Intervjuus tunnistab peaminister Juhan Parts end roheliseks poliitikuks, nimetab valitsusliitu parimaks võimalikuks ja soovitab tudengitel kõigepealt õppida ning annab valitsuse 100 päeva hindeks "neli miinus". Kommenteerivad: Evelyn Sepp, Tarmo Loodus, Ivari Padar

Vene Kultuurikeskus = The Russian Culture Centre / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinnas Mere puiestee 5 asuva hoone (arhitekt A. Kuznetsov, 1954) restaureerimisest. Arhitekt Niina Mäger, sisearhitekt Anne Tamverk. Ajaloolane Aleksandr Pantelejev. Žürii liikme Mait Summataveti hinnang kultuurkapitali aastapreemiale esitatud hoonele

Inimesed ja mesilased / Rein Tootmaa

Index Scriptorium Estoniae

Tootmaa, Rein

2005-01-01

Nukufilm "Gene+ratio" : stsenarist, kunstnik ja režissöör Mait Laas : konsultant Paavo Matsin : operaatorid Ragnar Neljandi, Raivo Möllits : helilooja Tiit Kikas : Nukufilm OÜ - Icon Film (Saksamaa) 2005

Tri gorsti za Tsentralnõi rõnok / Arvi Tapver

Index Scriptorium Estoniae

Tapver, Arvi

1999-01-01

Mõrvatud endise abilinnapea Mait Metsamaa keskturu erastajatest kaaskond kahlustas tunnistaja sõnul topeltmängu, kui Metsamaa vanale sõbrale ja allilmas kardetavale Meelis Laole erastamisest loobumise eest hüvitist pakkus

EMT nurjas Rate.ee ostuga Elisa kõnekaardiplaani / Gert D. Hankewitz

Index Scriptorium Estoniae

Hankewitz, Gert D.

2006-01-01

Ilmunud ka: Delovõje Vedomosti 12. apr. lk. 2. Elisa juhatuse esimehe Sami Seppäneni sõnul ostis EMT suhtlusportaali Rate.ee, kuna sai teada, et Elisa ning portaal plaanivad koos uue kõnekaardi turule tuua

Vana kaader järel-eesti ajal võimalusi proovimas / Maie Kalda

Index Scriptorium Estoniae

Kalda, Maie, 1929-2013

2001-01-01

Artikkel põhineb konverentsil "Kohandumise märgid" (20. apr. 2001) peetud ettekandel. Kirjanike elu- ja loominguloost a-tel 1944-1948, lähemalt Mait Metsanurgast, Hugo Raudsepast, Friedebert Tuglasest ja Oskar Lutsust

Viljandi laululava = Viljandi festival arena

Index Scriptorium Estoniae

2015-01-01

Viljandi laululava Talli tänav 2, valminud 2013. Arhitektid Ott Kadarik, Mihkel Tüür, Tanel Trepp (Kadarik Tüür Arhitektid OÜ), insenerid Tõnu Peipman, Viljar Sepp (IB Printsiip OÜ). Eesti Kultuurkapitali Arhitektuuri sihtkapitali aastapreemia 2014

Tummfilmiklassika kohtub maailmamuusikaga / Andreas Sepp

Index Scriptorium Estoniae

Sepp, Andreas

2011-01-01

Festivalist "Tummfilmid tõstavad häält", mis kestab 19.02.-5.03.2011. Filmi "Inimene filmikaameraga" (Venemaa, 1929) uushelindab Dead Combo, "Noored Kotkad" (Eesti, 1927/2008) Meelis Vind (Eesti) ja Napoleon Maddox (USA), "Berliin, suurlinna sümfoonia" (Saksamaa, 1927) ÖÄK, "Antenn" (Argentina, 2007) Argento Tango Fusion

Saaremaa politseijuht pensionile / Andres Sepp

Index Scriptorium Estoniae

Sepp, Andres, 1976-

2005-01-01

Kuressaare politseijaoskonna ülemkomissar Ants Ley esitas politseiametile lahkumisavalduse. Väidetavalt on nimetatud ühe võimaliku politseijuhikandidaadina Lääne prefektuuri teenistusosakonna komissari Aare Alliku nime. Lisa: Ants Ley

Sisearhitektuuri uudised / Aino Ingrid Sepp

Index Scriptorium Estoniae

Sepp, Aino Ingrid

2006-01-01

Keraamiliste plaatide müügisalongi "Interno" uue sisekujunduse autorid Eerik Olle ja Ahti Petersoo. Viking Windowsi peakontori (Jüri Okas) uue sisekujunduse ja "Sämmi grilli" (Toomas Rein) uue sisekujunduse autor Taevo Gans

Tallinna Loomeinkubaator = Creative Incubator in Tallinn / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinnas Veerenni 24C asuva Tallinna Loomeinkubaatori sisekujundusest. Sisearhitektid Raul Tiitus, Tarmo Piirmets (Pink OÜ), graafiline kujundus: Kaarel Vahtramäe (Velvet Studio). Žürii liikme Mait Summataveti hinnang kultuurkapitali aastapreemiale esitatud sisekujundusele

Juutide uurimine tõi tunnustuse : eesti teadlaste artikkel jõudis maailma tippajakirja / Marju Himma

Index Scriptorium Estoniae

Himma, Marju

2010-01-01

Juutide erinevate kogukondade genotüübilistele erinevuste uurimisrühma juhtideks olid Tartu Ülikooli ja Eesti Biokeskuse teadlased Doron M. Behar, Bayazit Yunusbayev, Mait Metspalu ja Richard Villems. Artikkel ilmus teadusajakirjas Nature

Mälestiste vastu ei sõdita / Mart Port

Index Scriptorium Estoniae

Port, Mart, 1922-2012

2004-01-01

Sõjaohvrite mälestamisest. Autori arvates sobib eesti leinajaid ühendavat ülesannet suurepäraselt täitma Maarjamäe memoriaal, kui see lõpetataks ja korrastataks. Kommenteerivad: Urmas Reinsalu, Evelyn Sepp, Paul-Eerik Rummo, Trivimi Velliste

Esilinastus väge täis "Mina olin siin" / Kutt Kommel

Index Scriptorium Estoniae

Kommel, Kutt

2008-01-01

Rene Vilbre noortefilm "Mina olin siin", mille aluseks on Sass Henno romaan "Mina olin siin. Esimene arest" : operaator Mait Mäekivi : osades Rasmus Kaljujärv, Hele Kõre jt : Amrion Productions - Helsinki-filmi OY 2008

Veider nelik jätkab!

Index Scriptorium Estoniae

2008-01-01

Arvutiga animeeritud USA koguperefilmist "Madagaskar 2" (lavastanud Tim McGrath ja Eric Darnell, eesti keeles loevad teksti Karol Kuntsel, Andero Ermel, Evelin Pang, Argo Aadli, Mait Malmsten, Raivo E. Tamm, Andrus Vaarik, Anne Reemann jt)

Endine turujuht end süüdi ei tunnistanud / Hannes Krause

Index Scriptorium Estoniae

Krause, Hannes

2005-01-01

Vadim Polishtshuk, keda süüdistatakse koos kahe kaaslasega Mait Metsamaa mõrvaprotsessi peamise tunnistaja ähvardamise ja mõjutamise katses, ei tunnistanud end 19. septembril Tallinna linnakohtus alanud protsessil süüdi

Akna varastamine : eesti Y-kirjandus / Berk Vaher

Index Scriptorium Estoniae

Vaher, Berk, 1975-

2014-01-01

Valdur Mikita, Erkki Luuk'i, Kiwa, Kaspari ja kirjanike rühmituse “14 NÜ” (Mait Laas, Paavo Matsin, Marko Mägi, Erkki Kadarik, Marianne Ravi, Maarja Vaino, Trip Jarvis, Johannes Üksi) loomingust

Eesti animafilmid võitsid Raumas

Index Scriptorium Estoniae

pPIK mare 2010

1999-01-01

VI Sinise Mere filmifestivalil Raumas jagasid A-sarjas esikohta Mait Laasi "Päevavalgus" ja Peep Pedmansoni "Just Märried", teiseks jäi Märt Sildvee "Guardian Angel" ja kolmandaks Riho Undi - Hardi Volmeri "Primavera"

Lõuka tuuliku restaureerimine / Dan Lukas

Index Scriptorium Estoniae

Lukas, Dan

2005-01-01

Hiiumaal Pühalepa vallas Vahtrepa külas Lõuka talu maadel asuva pukktuuliku ajaloost, restaureerimise käigust. Teostus: Dan Lukas. Muinsuskaitseline järelevalve: Tõnu Sepp, tema kommentaar. Ill.:pukktuuliku lõiked ja korruste plaanid, 7 värv. fotot

Pärnu uue kunsti muuseumis on näitus "Kümme aastat moodsat kunsti Pärnus varakapitalistliku Eesti tingimustes"

Index Scriptorium Estoniae

2003-01-01

Osalevad Peeter Allik, Mila Balti, Chintis, Margit Joonas, Toomas Kuusing, Hannes Paldrok, Meeland Sepp, Inge Ting, Taje Tross, Andrus Joonas, Bille Tuul, Mariliis Beilmann, Olle Meyer, Sorge, rühmitus Non Grata, Asta Isak, Marianne Männi, Ville-Karel Viirelaid

Impaired Homocysteine Transmethylation and Protein-Methyltransferase Activity Reduce Expression of Selenoprotein P: Implications for Obesity and Metabolic Syndrome

Science.gov (United States)

Obesity causes Metabolic Syndrome and Type-II Diabetes, disrupting hepatic function, methionine (Met)/homocysteine (Hcy) transmethylation and methyltransferase (PRMT) activities. Selenoprotein P (SEPP1), exported from the liver, is the predominate form of plasma selenium (Se) and the physiological S...

1 küsimus noorele juhile : Mis teha, kui kopp on ees - kuidas sa stressist jagu saad? / Riho Jürvetson, Merit Miller, Krister Rekkaro ... [jt.

Index Scriptorium Estoniae

2009-01-01

Küsimusele vastavad EMT erakliendi osakonna juhataja Riho Jürvetson, KPMG Baltics müügijuht Merit Miller, ArtPrint juht Krister Rekkaro, Dateli juhatuse liige Triin Sepp, Media House projektijuht Tanel Tarkmees, Ober-Haus Kinnisvara tegevjuht Katrin Klein-Näppi

Nukufilm lasi käiku pooletunnise 3D-seiklusfilmi / Tiit Tuumalu

Index Scriptorium Estoniae

Tuumalu, Tiit, 1971-

2009-01-01

Stuudios Nukufilm algasid pooletunnise 3D-nukufilmi "Lisa Limone ja Maroc Orange'i tormakas armulugu" võtted. Filmi režissöör on Mait Laas, stsenaristid Kati Kovacs ja Peep Pedmanson, produtsent Arvo Nuut

Inimkatse blondi eesti naise peibutustest Egiptuses / Liivi Shein

Index Scriptorium Estoniae

Šein, Liivi

2006-01-01

ETVs esilinastus 23. nov. "Eesti lugude" sarjas valminud "1001 öö muinasjutt ehk eesti naiste imelised seiklused Egiptuses" : režissöör Elo Selirand : toimetaja Anne-Mari Neider : operaator Mait Mäekivi : Osakond OÜ 2006

"Mina olin siin", võib vastu hambaid saada / Andres Keil

Index Scriptorium Estoniae

Keil, Andres, 1974-

2007-01-01

Noortefilmi "Mina olin siin" võtetel. Filmi aluseks on Sass Henno romaan "Mina olin siin. Esimene arest", stsenaariumi kirjutas Ilmar Raag, lavastab Rene Vilbre, operaator on Mait Mäekivi, peaosas Rasmus Kaljujärv, produtsendiks Riina Sildos

Meie mees Berliinis / Lauri Kärk

Index Scriptorium Estoniae

Kärk, Lauri, 1954-

2005-01-01

Berliini 55. filmifestivalist : Eesti filmist festivalil (Euroopa noorte režissööride lühifilmidest koosnevat projekti "Kaotatud ja leitud" raamib Mait Laasi nukufilm "Gener+atio"), inglaseDavid MacKenzie mängufilmist "Pelgupaik" ("Asylum")

Kirjandus ja vabamüürlus / Paavo Matsin

Index Scriptorium Estoniae

Matsin, Paavo, 1970-

2009-01-01

Loetletakse vabamüürlastest kirjanikke (pikemalt Jules Verne'ist, Gustav Meyrinkist, Rudyard Kiplingist ja Mait Metsanurgast) ning vabamüürlikke tegelasi või motiive kasutanud kirjanikke (Lev Tolstoi, Fjodor Dostojevski, Mihhail Bulgakov, Edgar Allan Poe)

Ülemiste kaubanduskeskus = Ülemiste shopping center / Priit Põldme ; kommenteerinud Linda Madalik

Index Scriptorium Estoniae

Põldme, Priit, 1971-

2015-01-01

Ülemiste kaubanduskeskus Tallinnas Suur-Sõjamäe 4. Sisekujunduse autorid Priit Põldme, Reet Sepp (sisearhitektuuribüroo Joonprojekt); arhitektid Einar Aakeroy (AMB Arkitekter), Lauri Laisaar, Ingel Sirkel-Suviste, Jaanika Oks, Katrin Kõlu (Novarc Group AS). Lühidalt Priit Põldmest ja Reet Sepast

Association between Polymorphisms in Glutathione Peroxidase and Selenoprotein P Genes, Glutathione Peroxidase Activity, HRT Use and Breast Cancer Risk

DEFF Research Database (Denmark)

Méplan, Catherine; Dragsted, Lars Ove; Ravn-Haren, Gitte

2013-01-01

Breast cancer (BC) is one of the most common cancers in women. Evidence suggests that genetic variation in antioxidant enzymes could influence BC risk, but to date the relationship between selenoproteins and BC risk remains unclear. In this report, a study population including 975 Danish cases...... and 975 controls matched for age and hormone replacement therapy (HRT) use was genotyped for five functional single nucleotide polymorphisms (SNPs) in SEPP1, GPX1, GPX4 and the antioxidant enzyme SOD2 genes. The influence of genetic polymorphisms on breast cancer risk was assessed using conditional...... logistic regression. Additionally pre-diagnosis erythrocyte GPx (eGPx) activity was measured in a sub-group of the population. A 60% reduction in risk of developing overall BC and ductal BC was observed in women who were homozygous Thr carriers for SEPP1 rs3877899. Additionally, Leu carriers for GPX1 Pro...

Kuidas tuua Eestisse Tiger Woods / Raul Ranne

Index Scriptorium Estoniae

Ranne, Raul

2008-01-01

Reaalselt arvestades on tõenäosus, et Eestit väisab golfistaar Tiger Woods, muidugi olematu. Teoreetiliselt on see siiski võimalik. Vestlusest Jõelähtme golfiväljakut opereeriv Estonian Golf Country Clubi presidendi Mait Schmidtiga

Ilmafilosoofia ilma filosoofiata / Jüri Rato

Index Scriptorium Estoniae

Rato, Jüri

2000-01-01

Arvustus: Hoff, Benjamin. Puhh ja Tao / tlk. Mait Talts. Tln. : Olympia, 1998 ; Hoff, Benjamin. Notsu ja Te / tlk. Paavo Kivine. Tln.: Olympia, 1999 ; Allen, Roger E. ; Allen, Stephen D. Puhh lahendab probleeme / tlk. Paavo Kivine. Tallinn : Olympia, 2000

Armastuse anatoomia / Peeter Laurits

Index Scriptorium Estoniae

Laurits, Peeter, 1962-

2007-01-01

Mängufilmist "Nuga" Peeter Sauteri ja Vaino Vahingu jutustuste motiividel : režissöör Marko Raat : peaosas Mait Malmsten : Allfilm, 2007. Samuti ka M. Raadi hiljuti valminud dokumentaalfilmist "F.F.F.F. läheb laiali"

Algasid Henno "Mina olin siin" järgi tehtava filmi võtted

Index Scriptorium Estoniae

2007-01-01

Eile algasid noortefilmi "Mina olin siin" võtted. Filmi aluseks on Sass Henno romaan "Mina olin siin. Esimene arest", stsenaariumi kirjutas Ilmar Raag, lavastab Rene Vilbre, operaator on Mait Mäekivi, peaosas Rasmus Kaljujärv, produtsendiks Riina Sildos

Improviseeritud lugu ja zhanriga mäng / Donald Tomberg

Index Scriptorium Estoniae

Tomberg, Donald

2003-01-01

Eesti komöödiafilm "Vanad ja kobedad saavad jalad alla" : režissöör Rando Pettai : operaator Mait Mäekivi : näitlejad Henrik Normann, Madis Milling, Robert Gutman jt. : muusika - ansambel Genialistid : Ruut Pictures 2003

Kas meie põllunduskoolid kasvatavad peremehi või sulaseid? / Heino Luiga, Vello Vilu, Kaul Nurm ...[jt.

Index Scriptorium Estoniae

2008-01-01

Küsimusele vastab Räpina aianduskooli direktor Heino Luiga, Järvamaa kutsehariduskeskuse põllumajanduse erialade juhtiv õpetaja Vello Vilu, Eesti talupidajate keskliidu peadirektor Kaul Nurm, Olustvere teenindus- ja maamajanduskooli direktor Arnold Pastak ning maaülikooli rektor Mait Klaassen

Keskmiselt kobe vaatamine / Küllike Rooväli

Index Scriptorium Estoniae

Rooväli, Küllike, 1969-

2004-01-01

Eesti komöödiafilm "Vanad ja kobedad saavad jalad alla" : režissöör Rando Pettai : operaator Mait Mäekivi : näitlejad Henrik Normann, Madis Milling, Robert Gutman jt. : muusika - ansambel Genialistid : Ruut Pictures 2003

Poola pole Ignalina plaane lukku löönud / Piotr Wozniak ; interv. Raimo Poom

Index Scriptorium Estoniae

Wozniak, Piotr

2007-01-01

Äsja laialisaadetud Poola valitsuse majandusministri sõnul soovib Poola olla Ignalina tuumaelektrijaama projektis aktiivne investor, st Poola soovib teatud osa selle kavandatavast võimsusest, minimaalselt 1000 MW. Meelis Atonen, Villu Reiljan ja Evelyn Sepp vastavad küsimusele, kas Ignalina suudab põlevkivienergiat asendada

Kolm tähelepanuväärset bibliograafiat / Tiina Ritson

Index Scriptorium Estoniae

Ritson, Tiina, 1955-

2011-01-01

Arvustus: Uku Masing 100 : bibliograafia 1923-2009 / koost. Anneli Sepp. Tartu : Ilmamaa, 2010. Voldemar Panso bibliograafia / koost. Katre Riisalu, Eha Garšnek, Mari Sibul. Tallinn : Eesti Draamateater, 2010. Pilv, Aare. Juhan Viidingu ja Jüri Üdi bibliograafia // Juhan Viiding, eesti luuletaja. Tartu, 2010.

Pärnus tähistatakse moodsa kunsti 10. aastapäeva

Index Scriptorium Estoniae

2003-01-01

Ülevaatenäitus Pärnu Uue Kunsti Muuseumis. Näitusel osalevad Peeter Mudist, Mila Balti, Chintis, Margit Joonas, Toomas Kuusing, Hannes Paldrok, Meeland Sepp, Inge Ting, Taje Tross, Andrus Joonas, Bille Tuul, Marliis Beilmann, Olle Meyes, Sorge, Non Grata, Asta Isak, Marianne Männi

Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma

Directory of Open Access Journals (Sweden)

Ayako Ishimori

2017-04-01

Conclusions: For the first time, our data showed that activated NK cells, ILC1s, ILC2s, ILC3s, and MAIT cells were positively correlated with each other and may be associated with airflow limitation in patients with asthma.

Poolsajandi õnnesoovid Jaak Aaviksoole / Ain Heinaru, Jaak Kangilaski, Tõnu Lehtsaar...[jt.

Index Scriptorium Estoniae

2004-01-01

Mõtteid Tartu Ülikooli rektorist tema 50. sünnipäeva puhul : Ain Heinaru, Jaak Kangilaski, Tõnu Lehtsaar, Indrek Reimand, Toomas Kiho, Leelo Kriisa, Peeter Olesk, Risto Tammelo, Birute Klaas, Peeter Saari, Andrus Ansip, Mait Klaassen, Marika Kullamaa, Kaupo Bend

Lihtsamatele töödele napib ladudes ja terminalides tööjõudu / Rivo Sarapik

Index Scriptorium Estoniae

Sarapik, Rivo, 1981-

2005-01-01

Ilmunud ka: Delovõje Vedomosti 2. nov. lk. 17. Teravnemas on terminali- ja laotööliste puudus, sest lihttöödele on keeruline töötajaid leida. Kommenteerivad: Andres Leht, Annika Lootus, Mait Miller ja Margus Tammaru

Absurd on igihaljas / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2006-01-01

Tutvustus: Camus, Albert. Õnnelik surm / tõlkinud Tanel Lepsoo. Tallinn : Varrak, 2005 ; Metsanurk, Mait. Kreeps / koost. Maire Liivamets. Tallinn : Eesti Raamat, 2005. (Eesti novellivara). Järg: 23. veebr., lk. 27, sisaldab Aivar Kulli kriitikakogu "Kulli pilk" (Ilmamaa, 2005) tutvustust

Sodom i Gomorra v glamurnoi miniatjure / Boris Tuch

Index Scriptorium Estoniae

Tuch, Boris, 1946-

2006-01-01

Jüri Sillarti mängufilm "Kuldrannake". Kunagise retrobändi kokkutulekut kujutava filmi stsenarist on Hans Luik oma näidendi "Tõe hetk" põhjal, operaator on Mait Mäekivi, produtsendid Kristian Taska ja Hans H. Luik, tootjafirmaks Taska Productions

Kas kõik poisid tahavad endale koju Barbit? / Andris Feldmanis

Index Scriptorium Estoniae

Feldmanis, Andris, 1982-

2006-01-01

Jüri Sillarti mängufilm "Kuldrannake". Kunagise retrobändi kokkutulekut kujutava filmi stsenarist on Hans Luik oma näidendi "Tõe hetk" põhjal, operaator on Mait Mäekivi, produtsendid Kristian Taska ja Hans H. Luik, tootjafirmaks Taska Productions

Geishade kataloog "Kuldrannakesel" / Kati Murutar

Index Scriptorium Estoniae

Murutar, Kati, 1967-

2006-01-01

Jüri Sillarti mängufilm "Kuldrannake". Kunagise retrobändi kokkutulekut kujutava filmi stsenarist on Hans Luik oma näidendi "Tõe hetk" põhjal, operaator on Mait Mäekivi, produtsendid Kristian Taska ja Hans H. Luik, tootjafirmaks Taska Productions

Vääritu film / Linnar Priimägi

Index Scriptorium Estoniae

Priimägi, Linnar, 1954-

2006-01-01

Jüri Sillarti mängufilm "Kuldrannake". Kunagise retrobändi kokkutulekut kujutava filmi stsenarist on Hans Luik oma näidendi "Tõe hetk" põhjal, operaator on Mait Mäekivi, produtsendid Kristian Taska ja Hans H. Luik, tootjafirmaks Taska Productions

Lihtsameelsed päästavad maailma / Urve Eslas

Index Scriptorium Estoniae

Eslas, Urve, 1972-

2006-01-01

Jüri Sillarti mängufilm "Kuldrannake". Kunagise retrobändi kokkutulekut kujutava filmi stsenarist on Hans Luik oma näidendi "Tõe hetk" põhjal, operaator on Mait Mäekivi, produtsendid Kristian Taska ja Hans H. Luik, tootjafirmaks Taska Productions

Homme esilinastuv uus Eesti film "Kuldrannake" flirdib terrorismiteemaga / Andris Feldmanis

Index Scriptorium Estoniae

Feldmanis, Andris, 1982-

2006-01-01

Jüri Sillarti mängufilm "Kuldrannake". Kunagise retrobändi kokkutulekut kujutava filmi stsenarist on Hans Luik oma näidendi "Tõe hetk" põhjal, operaator on Mait Mäekivi, produtsendid Kristian Taska ja Hans H. Luik, tootjafirmaks Taska Productions

Kilude paraad / Jaan Ruus

Index Scriptorium Estoniae

Ruus, Jaan, 1938-2017

2006-01-01

Jüri Sillarti mängufilm "Kuldrannake". Kunagise retrobändi kokkutulekut kujutava filmi stsenarist on Hans Luik oma näidendi "Tõe hetk" põhjal, operaator on Mait Mäekivi, produtsendid Kristian Taska ja Hans H. Luik, tootjafirmaks Taska Productions

Vilma lõpetab leivateo / Marko Suurmägi

Index Scriptorium Estoniae

Suurmägi, Marko, 1975-

2008-01-01

Vilma emafirma Kalev Chocolate Factory juhatuse liikme Mait Nilsoni sõnul jagab Kalev jahutoodete tegemise Jõhvi ja Viljandi ettevõtte vahel nii, et leiba ja saia hakatakse küpsetama Jõhvis ning Viljandisse koondub tortide, kookide ja jahusegude valmistamine. Lisa: Ajalugu

Eesti teadlaste artikkel juutide põlvnemisest jõudis tippajakirja / Marju Himma

Index Scriptorium Estoniae

Himma, Marju

2010-01-01

Eesti ja Iisraeli teadlaste rühm uuris juutide geneetilist sarnasust üle maailma. Artikkel avaldati rahvusvahelises teadusajakirjas Nature. Uurimisrühma juhtideks olid Tartu Ülikooli ja Eesti Biokeskuse teadlased Doron M. Behar, Bayazit Yunusbayevi, Mait Metspalu ja Richard Villems

Delta Plaza kohvik = The Delta Plaza Café / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinnas Pärnu mnt. 141 asuva kohviku Delta Plaza sisekujundusest. Sisearhitektid Tiiu Truus ja Marja Viltrop (Stuudio Truus OÜ). Hoone arhitektid Jüri Okas ja Marika Lõoke (AB J. Okas & M. Lõoke). Žürii liikme Mait Summataveti arvamus kohvikust

Mõisamuinasjutt / Helena Piip

Index Scriptorium Estoniae

Piip, Helena

2004-01-01

Jõuluaja veetmise võimalustest Palmse mõisas. Mõisarahvas kannab Mare Raidma kavandite järgi valmistatud 19. sajandi rõivaid. Keldri veini-, jahisaali jm. ruumide sisustuse on kavandanud Kalju Kivi, "Isabella" kohviku on kujundanud Leila Pärtelpoeg. Sepikojas (sepp Kaupo Kangur) saab õnne valada ja rauda taguda

Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women

International Nuclear Information System (INIS)

Dyke, A. L. V.

2009-01-01

In a population-based case-control study, we explored the associations between 42 polymorphisms in seven genes in this region and non-small cell lung cancer (NSCLC) risk among Caucasian (364 cases; 380 controls) and African American (95 cases; 103 controls) women. Two TERT region SNPs, rs2075786 and rs2853677, conferred an increased risk of developing NSCLC, especially among African American women, and TERT-rs2735940 was associated with a decreased risk of lung cancer among African Americans. Five of the 20 GHR polymorphisms and SEPP1-rs6413428 were associated with a marginally increased risk of NSCLC among Caucasians. Random forest analysis reinforced the importance of GHR among Caucasians and identified AMACR, TERT, and GHR among African Americans, which were also significant using gene-based risk scores. Smoking-SNP interactions were explored, and haplotype in TERT and GHR associated with NSCLC risk were identified. The roles of TERT, GHR, AMACR and SEPP1 genes in lung carcinogenesis warrant further exploration

101 riigikogulast said valijalt ehmatava liputervituse / Tuuli Koch

Index Scriptorium Estoniae

Koch, Tuuli

2006-01-01

Ilmunud ka: Postimees : na russkom jazõke 4. sept. lk. 4. Valija Tiina Talts saatis presidendivalimiste esimese päeva hommikul parlamendiliikmetele kirja, mille juurde oli ümber disainitud Eesti lipp. Vastused saatsid neli saadikut, nende hulgas Mait Klaassen, Jaak Allik, Janno Reiljan

Nõmme Lunastaja kirik = The Saviour's Lutheran Church in Nõmme / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinnas Õie 10 asuva kirikuhoone (arhitekt Robert Natus, 1932) restaureerimisest. Arhitekt Fredi-Armand Tomps, sisearhitekt Anne Koppel, ehitusjärelevalve: Rein Joller, ajaloolane Aleksandr Pantelejev. Žürii liikme Mait Summataveti hinnang EK arhitektuuri sihtkapitali 2009. a. restaureerimispreemia pälvinud hoonele

Toompea komandandimaja = The Commandant's House in Toompea / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinnas Toompea 1 asuva hoone restaureerimisest. Arhitekt Raul Vaiksoo, kaasautor Kristo Vaiksoo (Raul Vaiksoo Arhitektuuribüroo), sisearhitektid Priit Põldme, Rita Rahu (SAB Joonprojekt), Raul Vaiksoo, ajaloolased Raul Vaiksoo, Aleksandr Pantelejev. Žürii liikme Mait Summataveti hinnang kultuurkapitali aastapreemiale esitatud hoonele

Võtme ja riiviga tantsufilm / Kristiina Garancis

Index Scriptorium Estoniae

Garancis, Kristiina, 1969-

2005-01-01

Rahvusvahelises ühistöös valminud tantsufilm "Teine" ("Another") : režissöör Rene Vilbre : stsenaristid Rene Vilbre, Teet Kask, Helena Jonsdottir : produtsent Heidi Pruuli : koreograaf ja peaoaline Helena Jonsdottir : osatäitjad Mait Malmsten, Ruslan Stepanov : Eesti - Island 2005

Rohkem kui lihtsalt tantsufilm / Tiit Tuumalu

Index Scriptorium Estoniae

Tuumalu, Tiit, 1971-

2005-01-01

Rahvusvahelises ühistöös valminud tantsufilm "Teine" ("Another") : režissöör Rene Vilbre : stsenaristid Rene Vilbre, Teet Kask, Helena Jonsdottir : produtsent Heidi Pruuli : koreograaf ja peaoaline Helena Jonsdottir : osatäitjad Mait Malmsten, Ruslan Stepanov : Eesti - Island 2005

Paugub püstol, lendavad kilud / Olev Remsu

Index Scriptorium Estoniae

Remsu, Olev, 1947-

2006-01-01

Jüri Sillarti mängufilm "Kuldrannake". Kunagise retrobändi kokkutulekut kujutava filmi stsenarist on Hans Luik oma näidendi "Tõe hetk" põhjal, operaator on Mait Mäekivi, produtsendid Kristian Taska ja Hans H. Luik, tootjafirmaks Taska Productions. Pikemalt stsenaariumist

Superorgaaniline animatsioon / Jan Kaus

Index Scriptorium Estoniae

Kaus, Jan, 1971-

2006-01-01

Eesti uuemast animafilmist. Põhjalikumalt on käsitletud 2005.a. eesti animatsioonikunsti tippteosena Mait Laasi filmi "Generatio". Lisatud lühiandmed M. Laasi kohta, samuti kuue riigi koostööfilmi "Kaotatud ja leitud" kohta, mille lühifilmid seob tervikuks "Generatio"

Meie näitekirjandus aastal 1931 / Ants Oras

Index Scriptorium Estoniae

Oras, Ants, 1900-1982

2009-01-01

Ülevaade 1931. aasta eesti näitekirjandusest. Pikemalt käsitletakse: Mait Metsanurk "Mässuvaim, ehk, Agulirahvas läheb ajalukku", Hugo Raudsepp "Põrunud aru õnnistus", Agnes Taar "Emake maamuld", Aleksander Antson "Töölise tütar", Artur Adson "Neli kuningat"

Näitleja Anti Reinthal : "Kui sa just surnud ei ole, siis mängid lõpuni!" / Katrin Rohtla

Index Scriptorium Estoniae

Rohtla, Katrin, 1966-

2007-01-01

Viinistu kunstimuuseumis etenduva Eesti Draamateatri suvelavastuse "Sürrealistid" 30. juuni etenduses vigastas näitleja raskelt oma reielihast kuid mängis lõpuni. Lisaks Mait Malmsteni kommentaar "Malmsten : "Esimene vaatus mängiti fantaasia abil" ja vaataja arvamus : "Publiku pettis ära"

Arhitektuurivõistlused 2008 / Mait Väljas

Index Scriptorium Estoniae

Väljas, Mait

2008-01-01

Võistluste tulemused: Pekingi saatkonnahoone: I preemia - A. Põime, L. Põime, L. Vaimel; Riia saatkonnahoone: I - L.-K. Stöör, Ü.-T. Stöör, H. Urb; Eesti Kunstiakadeemia uus õppehoone: I - SEA + Effekt (Taani); Eesti Maaülikooli Kreutzwaldi 5 õppehoone juurdeehitis: I - P. Loo, J. Skolimowski, L. Vene, K. Kruuse (KAMP Arhitektid); TÜ Viljandi Kultuuriakadeemia loomeinkubaatori ja lavakunstide õppehoone: I - S. Vallner, H. Urb, I. Peil, H. Lass, S.-M. Mändmaa (Kavakava); Tamula järve ranna-ala mahuline planeering: I - K. Enno, L. Luhse, M. Zeleznova, R. Ailt (K. Enno Arhitektuuribüroo); Tartu pärmivabriku kvartali arhitektuurivõistlus: võidutöö - Atelier Thomas Pucher / Bramberger Architects (Austria); Paldiski mnt. 50 kinnistu ja lähiala: I-II - T. Laigu, K. Ojaliiv, M. Rass, A. Uukado (QP Arhitektid); maastikuarhitektuuri võistlus "Eesti Maaülikooli Tähtvere linnaku välialad": I - H. Runnel, T. Ong; Tartu rahu tähisala kujundus: I - M. Kinks, K. Süda; Veneetsia XI rahvusvahelise arhitektuuribiennaali ideekavandi võistlus: I - M. Kask, R. Lõoke, N. Külm; aasta betoonehitis 2007 - Puurmani kaarsild, konstruktorid S. Idnurm, J. Idnurm; Eesti parim puitehitis 2008: eramu Loobul - R. Vaiksoo; võistluse "Eramu 2006-2007" peapreemia: villa Paldiskis - S. Vallner, I. Peil

Birma - otsekui retk minevikku / Mait Talts

Index Scriptorium Estoniae

Talts, Mait, 1964-

2011-01-01

Reisist Birmasse, tänapäevase nimega Myanmari, mida Eestiga seovad sinna maetud "Eestimaa budistlikud peapiiskopid" Karl A.M. Tõnisson-Tennisons (Vend Vahindra, 1883-1962) ja Friedrich Voldemar Lustig (Ashin Ananda, 1912-1989)

The tyger = Tiiger : [luuletus] / William Blake

Index Scriptorium Estoniae

Blake, William

1997-01-01

W. Blake'i luuletus 'Tiiger' originaalis ja seitsmes eri tõlkes, tõlkijateks Ilmar Laaban, Toivo Pilli, Rein Sepp, Ene-Reet Soovik, Jüri Talvet, Udo Uibo ja Märt Väljataga.Vt. ka Märt Väljataga artiklit 'Luule tõlkimine ja 'Tiiger'' Vikerkaares 1997, nr. 6

Paet: suure kindlusega võib öelda, et eestlased on elus / Ilmar Kahro

Index Scriptorium Estoniae

Kahro, Ilmar

2011-01-01

Vahendatud intervjuu välisminister Urmas Paetiga, kes märgib, et viimases Liibanonis röövitud eestlaste videos pöörduvad nad sugulaste poole. Eesti juhtiv riigiprokurör Heili Sepp oli 10.-13. juulini lähetuses Liibanonis, kus oli kohtunud kõrgete kohalike ametnikega

Mida paljastas nutitelefoni lõhkumine? / Villu Zirnask

Index Scriptorium Estoniae

Zirnask, Villu, 1966-

2011-01-01

Soome majandusuuringute instituudi teadurid ja elektroonikainsenerid Jyrki Ali-Yrkkö, Petri Rouvinen, Timo Seppälä ja Pekka Ylä-Anttila analüüsisid uuringus "Who Captures Value in Global Supply Chains? Case Nokia N95 Smartphone" nutitelefoni hinnakujundust. Detailihindade, koostehindade ja lõpphinna suhe. Diagramm.

Baltika büroo = The Baltika Offices / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinnas Veerenni 24 asuvast Baltika büroost. Arhitektuur, bürooruumide kujundus: AB Studio 3, Kolm Pluss Üks Arhitektid. Žürii liige Mait Summatavet žürii hinnangust EK arhitektuuri sihtkapitali 2009. a. sisearhitektuuri preemia pälvinud bürooruumidele

Jüri Sillart alustab uue mängufilmi võtteid / Mart Rummo

Index Scriptorium Estoniae

Rummo, Mart

2005-01-01

J. Sillart alustas Maardu mõisas uues mängufilmi "Kuldrannake" võtteid. Kunagise retrobändi kokkutulekut kujutava filmi stsenarist on Hans Luik sen oma näidendi "Tõe hetk" põhjal, operaator on Mait Mäekivi, produtsent Kristian Taska, tootjafirmaks Taska Productions

Kuldrannakese virvatuled / Tarmo Teder

Index Scriptorium Estoniae

Teder, Tarmo, 1958-

2006-01-01

Jüri Sillarti mängufilmi "Kuldrannake" eilse esilinastuse puhul. Kunagise retrobändi kokkutulekut kujutava filmi stsenarist on Hans Luik sen oma näidendi "Tõe hetk" põhjal, operaator on Mait Mäekivi, produtsendid Kristian Taska ja Hans H. Luik, tootjafirmaks Taska Productions

Eesti osaleb suurejoonelises filmiprojektis

Index Scriptorium Estoniae

pPIK mare 2010

2004-01-01

Filmiprojekt tööpealkirjaga "Generation", mis on plaanitud täispikaks mängufilmilaadseks filmiks. Tegemisse on kaasatud kuus noort režissööri Ida-Euroopast. Eestit esindab animafilmide režissöör Mait Laas, kes teeb valmivale filmile raamjutustuse

Loomad räägivad sel korral eesti keeles / Jaanus Noormets

Index Scriptorium Estoniae

Noormets, Jaanus

2008-01-01

Arvutiga animeeritud USA koguperefilmist "Madagaskar 2" (Madagascar: Escape 2 Africa), mis jõuab Eesti kinodesse erinevalt filmisarja esimesest osast eesti keelde dubleerituna (loomtegelastele on oma hääle laenanud Karol Kuntsel, Andero Ermel, Evelin Pang, Mait Malmsten, Raivo E. Tamm, Andrus Vaarik jt)

Vanglamüüride vahel võeti üles tantsufilmi / Villu Päärt

Index Scriptorium Estoniae

Päärt, Villu, 1972-

2005-01-01

ETV-l valmib koos EFS-i ja Estinfilmiga kultuurikanali ARTE tellimusel tantsufilm "Teine" : režissöör Rene Vilbre : stsenarist Teet Kask : produtsent Heidi Pruuli : koreograaf ja peaoaline Helena Jonsdottir : osatäitjad Mait Malmsten, Ruslan Stepanov. Filmi võtetest Tartu vanglas

Ristipoja mälestusi / Reino Sepp

Index Scriptorium Estoniae

Sepp, Reino

2005-01-01

Reino Sepa mälestusi Johannes Aavikust. Katkendid on võetud tema varem ilmunud artiklist "Mälestusi ja mõteid Johannes Aavikust", mis ilmus 1991. aastal ajalehe Meie Maa väljaandes "Minu Saaremaa"

Auhinnatud Hollandi saatkond Berliinis / Aino Sepp

Index Scriptorium Estoniae

Sepp, Aino

2005-01-01

Hollandi saatkonna hoonest - arhitektid Rem Koolhaas (sünd. 1944) ja Ellen van Loon arhitektuuribüroost OMA (Ofice for Metropolitan Architecture) - Berliinis. Väljaspoolt viiekordsena mõjuvas majas on kaheksa tasandit. Hoone võitis 2005. a. Mies van der Rohe nimelise arhitektuuripreemia. Rem Koolhaasist. 12 värv. ill

Pokoja net kak net / Evelyn Sepp

Index Scriptorium Estoniae

Sepp, Evelyn, 1972-

2007-01-01

Riigikogu liige loodab, et peale valimisi kaitseminister Jürgen Ligi poolt kokku kutsutud sõjahaudade komisjon ei kiirusta enam oma otsuste tegemisega, millega võiks kaasneda pronkssõduri teisaldamine

Kitsas silmaring on nuhtluseks endale, teistele, kogu riigile / Raivo Juurak, Kaiko Lippur

Index Scriptorium Estoniae

Juurak, Raivo, 1949-

2014-01-01

Westholmi Gümnaasiumi riigikaitseõpetuse õppetooli juhataja Kaiko Lippur selgitab, et riigikaitseõpetus on eelkõige õpilaste silmaringi laiendamiseks. Küsimusele, mida riigikaitseõpetus annab, vastavad Westholmi gümnaasiumi õpilased Jaan Kaarel Sepp, Marie Helen Lisete Kikas ja Kaisa-Mai Kallaste ning Rocca al Mare kooli lapsevanem Katariina L. Martens

Põimunud ajastud vanalinnakodus / Helle Neemre

Index Scriptorium Estoniae

Neemre, Helle

1998-01-01

Kaasajastatud vanalinnakorter Väike-Karja tänavas. Muljeid ja meenutusi tehtust sisekujundaja Helle Neemrelt. Pildiallkirjad - Jüri Kuuskemaa. Korterist võib leida Hansa-aegseid detaile, regionalistlikku laadi, moodsaid mugavusi kaasaegses kujunduses. Sepised (kardinapuud, trepikäsipuu, kaminariistad, -rest) - sepp Raivo Uus. Paekivist detailid restaureeris KAR Grupp. Diivan ja laud - Mang.

3G nõrk pulss ärikliendile

Index Scriptorium Estoniae

2005-01-01

Mobi turundusjuht Rain Rannu, Elisa tegevjuht Sami Seppänen, EMT arendus- ja tehnoloogiadirektor Tõnu Grünberg ning andmeside ja sisuteenuste juht Ando Meentalo vaagivad nn kolmanda mobiilipõlvkonna 3G plusse ja miinuseid ning võimalusi Eesti turul läbi lüüa. Lisa: Mobiilivõrgud

Muusika / DJ Pickney Tiger

Index Scriptorium Estoniae

DJ Pickney Tiger, pseud., 1970-

2008-01-01

Kontsertidest: ansamblid Haydamaky ja Svjata Vatra 14. nov. Tallinnas Amigos ja 15. nov.Viljandis Pärimusmuusika Aidas, 11. nov. Anzori Barkalaja ja Silver Sepp Viljandis Pärimusmuusika Aidas, üritustest Roll & Bass, Rock ja Roll 29. nov. Tartus, Jõulujazz 29. nov. -16. dets., Tricky 20. nov. Tallinnas Rock Cafés

Jõgeva bussijaam sai liimpuidu kasutamise eripreemia

Index Scriptorium Estoniae

2009-01-01

Konkursil Eesti Parim Puitehitis 2009 sai liimpuidu kasutamise eripreemia Jõgeva bussijaam, arhitektid Andres Lunge ja Mait Lauri firmast Lunge & Co OÜst. Peapreemia pälvis suvila Jõelähtmel, arhitekt Sten Ader büroost SKAD Arhitektid. Loetletud ka teisi auhinnalistele kohtadele tulnud töid

Tartu kalendritootja investeeris uude tehasesse 100 miljonit / Kadrin Karner

Index Scriptorium Estoniae

Karner, Kadrin

2008-01-01

Ilmunud ka: Delovõje Vedomosti 24. sept. lk. 5. Tartus avatud Ajasto Diary Groupi kalendritehasesse investeeriti üle 100 miljoni krooni, mille tasuvuspiiriks loeb ettevõte umbes kümme aastat. Vt. samas: Mis on mis: Ajasto Diary Group; Kommenteerivad: Mait Puusepp, Andras Metsa, Kadrin Karner

Vanglarahvas tantsib Euroopasse / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2005-01-01

Rahvusvahelises ühistöös valminud tantsufilm "Teine" ("Another") : režissöör Rene Vilbre : stsenaristid Rene Vilbre, Teet Kask, Helena Jonsdottir : produtsent Heidi Pruuli : koreograaf ja peaoaline Helena Jonsdottir : osatäitjad Mait Malmsten, Ruslan Stepanov. Filmi võtted toimusid Tartu vanglas

Mahtra muuseumis ja Juuru vallas käisid auväärsed külalised / Tiia Truu

Index Scriptorium Estoniae

Truu, Tiia, 1948-

2009-01-01

1. juulil 2009 külastasid Mahtra talurahvamuuseumi Mahtra sõja mälestusmärgi looja Johannes Tuti lesk Leili Tutt ja nende poeg Mait Tutt Rootsist ning tütar Eha Dascenzo USA-st Swanscast, nendega koos oli J. Tuti vennatütar Maie Vikat

Tantsuime: märjaks nutetud Märt Agu saab 8000 uut sõpra / Märt Agu ; intervjueerinud Rein Sikk

Index Scriptorium Estoniae

Agu, Märt, 1980-

2011-01-01

11. Noorte tantsupeo "Maa ja ilm" üldjuht ja Tallinna Tantsuakadeemia kunstiline juht Märt Agu Tallinna lauluväljakul toimuvast tantsupeost, ülevaatustest, eesti meeste rahvatantsust, oma isast Mait Agust, tema tantsust "Põhjamaa", tantsuõpetaja elukutsest, eesti tantsust, Tallinna Tantsuakadeemiast. Andmeid Märt Agu loomingu kohta

Võigas ja seletamatu tsirkus : kaasaja ja alateadvuse pained "Agent Sinikaelas" / Sven Vabar

Index Scriptorium Estoniae

Vabar, Sven

2002-01-01

Mängufilm "Agent Sinikael" : stsenaristid Marko Raat ja Andres Maimik : režissöör Marko Raat : operaator Arko Okk : helilooja Janek Murd : kunstnikud Margus Tammik ja Jaana Jüris : nimiosas Mait Malmsten : produtsendid Peeter Urbla ja Veiko Õunapuu : Exitfilm ja Suhkur Film, 2002

Vikergallup : eesti kirjandus 2012 / Vahur Afanasjev, Joanna Ellmann, Peeter Helme ... [jt.

Index Scriptorium Estoniae

2013-01-01

Erinevate kriitikute arvamus 2012. aastal Eestis ilmunud nüüdiskirjandusest. Aasta parimaks uudisteoseks nimetati Peeter Sauteri "Märkmeid vaeste kirjanike majast", parimaks debüüdiks Mait Vaigu luulekogu "Kõigil on alati õigus", parimaks tõlkeraamatuks Georges Pereci romaan "Elu, kasutusjuhend" ja Pentti Saarikoski koondkogu "Luuletused"

Nick Park pani Wallace'ile ja Gromitile libaküüliku needuse / Mart Rummo

Index Scriptorium Estoniae

Rummo, Mart

2005-01-01

Uus animafilm "Wallace ja Gromit : Libaküüliku needus" ("Wallace & Gromit : The Curse of the Were-Rabbit") : režissöör Nick Park : Suurbritannia 2005. Selle loojast ja tema loometeest. Lisatud : Nick Park (filmograafia, auhindu), "Teised Nick Parkist" (Lauri Kaare, Mait Laas, Riho Unt)

Kuus uut Eesti filmi korraga ekraanil / Tarmo Teder

Index Scriptorium Estoniae

Teder, Tarmo

1998-01-01

21. mail esilinastuvad kinos Sõprus 'Just märried', rezh. Peep Pedmanson; 'Päevavalgus', rezh. Mait Laas; 'Primavera', rezh. Riho Unt ja Hardi Volmer; 'Vares ja hiired', rezh. Priit Tender ja Mikk Rand; 'Bermuda', rezh. Ülo Pikkov; 'Tom ja Fluffy', rezh. Janno Põldma ja Heiki Ernits

Sami Seppänen : kõnehinna langus hakkab otsa saama / Sami Seppänen ; interv. Henrik Ilves

Index Scriptorium Estoniae

Seppänen, Sami

2007-01-01

Elisa juhatuse esimehe hinnangul halvab hindade tõstmine ja siis ümberotsustamine mulje kogu mobiilside tegevusalast. Elisa ei kaalunud võimalust EMT sammuga - võtta kasutusele minutipõhine kõnearvestus - kaasa minna, kuid pole välistatud, et tulevikus Elisa seda teeb. Lisa: Konkurendid on sama meelt

Sõpruses esilinastub Eesti-Islandi tantsufilm

Index Scriptorium Estoniae

2005-01-01

10. novembril esilinastub rahvusvahelises ühistöös valminud tantsufilm "Teine" ("Another") : režissöör Rene Vilbre : stsenaristid Rene Vilbre, Teet Kask, Helena Jonsdottir : produtsent Heidi Pruuli : koreograaf ja peaoaline Helena Jonsdottir : osatäitjad Mait Malmsten, Ruslan Stepanov. Filmi võtted toimusid Tartu vanglas

Wow! Tallinn! / Jaak Rand

Index Scriptorium Estoniae

Rand, Jaak

2006-01-01

Jüri Sillarti mängufilm "Kuldrannake". Kunagise retrobändi kokkutulekut kujutava filmi stsenarist on Hans Luik oma näidendi "Tõe hetk" põhjal, operaator on Mait Mäekivi, produtsendid Kristian Taska ja Hans H. Luik, tootjafirmaks Taska Productions. Lisatud Jüri Sillarti filmograafia lk. 83

Nirvaana, susla ja internet / Tarmo Teder

Index Scriptorium Estoniae

Teder, Tarmo, 1958-

2000-01-01

Kolm stuudio Nukufilm uut nukufilmi : "Saamueli Internet" : Stsenarist Andrus Kivirähk : režissöör ja kunstnik Riho Unt; "Teekond Nirvaanasse" : Stsenarist, režissöör ja kunstnik Mait Laas; "Eilne vedur" : režissöörid Mikk Rand ja Kalju Kivi

Ilma tahtmata ja teadmata paradiisi ehk Arhetüüp eesti moodi / Rein Tootma

Index Scriptorium Estoniae

Tootma, Rein

2006-01-01

Lühimängufilm "Vanameeste paradiis" : stsenaristid Ove Musting (ka idee autor), Urmas Lennuk : režissöör Ove Musting : operaator Mait Mäekivi : helilooja Arian Levin : kunstnik Eva-Marina Gramanovski : näitlejad Tõnu Aav, Aleksander Eelmaa, Tõnu Oja, Ants Ander, Henry Kõrvits : Downtown Pictures 2005

Ära kosi Pikka: Pikk läheb pingile magama / Meelis Oidsalu

Index Scriptorium Estoniae

Oidsalu, Meelis, 1978-

2010-01-01

Kevadel lavakunstikooli lõpetavate tudengite lavastusest "Pikk pink" , mis koosneb kuuest lühiloost - Mait Jooritsa "Kantani padi", Kristjan Üksküla "Jääger" ja "Albioni tütar", Roland Laosi "Genees ja katastroof", Hendrik Toompere jun. "Karupoeg Puhh" ja Kerttu Moppeli " Leib!". Esietendus 23. nov. Hobuveskis

Lavaka lõpetajate pink on pikk / Tiiu Laks

Index Scriptorium Estoniae

Laks, Tiiu, 1984-

2009-01-01

Kevadel lavakunstikooli lõpetavate tudengite lavastusest "Pikk pink" , mis koosneb kuuest lühiloost - Mait Jooritsa "Kantani padi", Kristjan Üksküla "Jääger" ja "Albioni tütar", Roland Laosi "Genees ja katastroof", Hendrik Toompere jun. jun. "Karupoeg Puhh" ja Kerttu Moppeli " Leib!". Etendused toimuvad Hobuveskis

USAs avati suurim Balti kunsti näitus / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2002-01-01

New Jerseys Rutgersi ülikooli kunstimuuseumis on väljas 190 Eesti, Läti ja Leedu kunstniku tööd Norton ja Nancy Dodge'i mitte-konformistliku nõukogude kunsti kollektsioonist, mille omanikud ülikoolile kinkisid. Näitusekataloogi artiklid on kirjutanud Juta Kivimäe, Eha Komissarov, Sirje Helme ja kanadalane Eha Sepp

Ostetud lõputööga saaks ülikoolidiplomi kätte küll / Kristi Leppik

Index Scriptorium Estoniae

Leppik, Kristi

2008-01-01

Plagiaadist, autoriõigusest ja lõputööde ostmisest ajakirjandusliku eksperimendina korraldatud õigusteaduse bakalaureuse lõputöö hankimise näitel Kommenteerivad Tallinna Tehnikaülikooli ehitusteaduskonna dekaan Roode Liias, Akadeemia Nord õigusteaduste dekaan Aare Kruuser, Tartu Ülikooli majandusteaduskonna arenduspordekaan Jüri Sepp, Tallinna Ülikooli riigireaduste instituudi direktor Leif Kalev

Selenoprotein P in colitis-associated carcinoma

Science.gov (United States)

Short, Sarah P.; Whitten-Barrett, Caitlyn; Williams, Christopher S.

2016-01-01

ABSTRACT Patients with inflammatory bowel disease are often deficient in micronutrients such as selenium and have an increased risk of colon cancer. We tested whether the selenium transport protein, selenoprotein P, could modify colitis-associated cancer. Our results indicate that global SEPP1 haploinsufficiency augments tumorigenesis and mediates oxidative damage in the intestine. PMID:27314080

Männik ohverdas Aaviksoo

Index Scriptorium Estoniae

2003-01-01

Eesti Telekomi nõukogu otsusest vabastada ametist EMT juhatuse esimees Peep Aaviksoo, uuest kandidaadist Valdo Kalmust ning EMT ja Elioni võimalikust ühinemisest. Diagramm: EMT turuosa libiseb Tele2-le. Vt. samas: EMT lahkuva juhi Peep Aaviksoo avalik kiri. Kommenteerivad Sami Seppänen, Üllar Jaaksoo, Monika Salu, Jaak Aaviksoo, Toomas Tamsar

Minutipõhise hinnaarvestuse katse - kas julgus või rumalus? / Imbi Ernits-Kaljuste

Index Scriptorium Estoniae

Ernits-Kaljuste, Imbi, 1963-

2008-01-01

EMT teatas 2007. aasta sügisel üleminekust mobiilikõnede minutipõhisele hinnaarvestusele, mis tõi kaasa avalikkuse pahameele, seejärel teatas EMT plaanist loobumisest. Autor tõstatab küsimuse, kumma teatega tegi EMT vea. Kommenteerivad Kaja Pino, Janek Mäggi, Kristjan Seema, Daniel Vaarik, Sami Seppänen, Ivo Rull

Mobiilside uustulnukad võtavad alles hoogu / Villy Paimets

Index Scriptorium Estoniae

Paimets, Villy, 1972-

2004-01-01

Uued mobiilsideoperaatorid Vertelson Mobiil, CityGSM ja Top Connect valmistuvad turuletulekut ette. Vt. samas: Villy Paimets. Mobiilsideturul tüli majas. OÜ Top Connect konflikti kavandatavate teenuste osutamise pärast läbi Radiolinja võrgu kommenteerivad Radiolinja Eesti juhatuse esimehelt Sami Seppänenilt ja OÜ Top Connect juhatuse liikmelt Vladislav Sobolevilt

Vilsandi merepäästejaama paadikuur ja slipp = Vilsandi sea rescue station boathouse and slip

Index Scriptorium Estoniae

2015-01-01

Vilsandi merepäästejaama paadikuur ja slipp Kihelkonna vallas Saare maakonnas. Arhitektuuri sihtkapitali restaureerimispreemia 2012 lagunemisele määratud väikeobjekti uuele elule toomise eest. Arhitektid Emil Urbel, Ainar Luik (AB Emil Urbel). Värava embleemi taastamine Tiit Pääsuke. Muinsuskaitse eritingimused Leele Välja, muinsuskaitseline järelevalve Tõnu Sepp

Eesti animafilmid Ottawas / M. L.

Index Scriptorium Estoniae

M. L.

2006-01-01

Ottawa rahvusvahelisel animafilmifestivalil 20.-24. sept. võistlesid Eesti poolt Mati Küti "Une instituut" ja "Vulcain.Cricet", Priit Tenderi "Sõnum naabritele", Ülo Pikkovi "Elu maitse" ja Mait Laasi "Generatsioon". Eesti auhindu ei saanud. Peaauhind täispika animatsiooni eest läks inglasele Phil Mulloy'le filmi "Christied" eest

"Riigikogu hoone 90" = "Estonian parliament building 90" / Janno Roos, Andres Labi

Index Scriptorium Estoniae

Roos, Janno, 1976-

2013-01-01

Eesti Sisearhitektide Liidu 2012. aasta näituse kujunduse preemia pälvinud näitusest (Lossiplats 1A). Kujunduse autorid Janno Roos ja Andres Labi (Ruumilabor). Kuraator Mait Väljas. Graafiline disain: Identity. Sisearhitekti ja ESLi aastapreemiate žürii liikme Mari Kurismaa ning arhitektuuriajaloolase Leele Välja arvamused

Väikeelamine suureks - normaalpere konteinersüsteemis = Small living space made bigger - container system for a typical family

Index Scriptorium Estoniae

2009-01-01

Tutvustatakse Tallinna Tehnikakõrgkooli Arhitektuuri Instituudi arhitektuuri eriala üliõpilaste töid teemal "Väikeelamine suureks - normaalpere konteinersüsteemis". Idee: rahuldada ühesuuruste "konteinerite" baasil ehitatud torn- või ridamajadega väikekorterite nõudlust. Juhendaja: sisearhitekt Mait Summatavet (lk. 60 andmeid M. Summataveti elu ja loomingu kohta)

Tantsufilm "Teine" ETV-s

Index Scriptorium Estoniae

2005-01-01

Täna on ETV-s rahvusvahelises ühistöös valminud tantsufilm "Teine" ("Another") : režissöör Rene Vilbre : stsenaristid Rene Vilbre, Teet Kask, Helena Jonsdottir : produtsent Heidi Pruuli : koreograaf ja peaoaline Helena Jonsdottir : osatäitjad Mait Malmsten, Ruslan Stepanov. Filmi võtted toimusid Tartu vanglas

Paariselamu Luccas = Duplex House in Lucca / Indrek Allmann

Index Scriptorium Estoniae

Allmann, Indrek, 1972-

2001-01-01

Projekteerija: Arhitektuuribüroo Kolde Grupp. Arhitekt Indrek Allmann, konstruktorid Andres Läänesaar, Aldur Parts, Valdo Jaanisoo, Mait Mets. Hoone asub panga ülemise tasandi kõrgusel õhus, pangapealsega on ühendatud terrassi abil, ligipääs alumisel tasandil. Projekt 1999, valmis 2001. 5 ill.: põhiplaan, vaated

Baltic beer market : close neighbours, different situations

Index Scriptorium Estoniae

2004-01-01

Baltimaade juhtivate õlletootjate marketingijuhid Martins Dzenis (Cesu Alus), Inita Drezina (Aldaris), Eriks Kalita (Livu Alus), Raimonds Kalnins (Kimmel), Dalius Rutkauskas (AB Ragutis), Dainius Smailys (Svyturis-Utenos Alus), Katrin Vernik (A. Le Coq Eesti), Karin Sepp (Saku Õlletehas) ja Härmo Põlluvee (Frederik Viru Õlu) olukorrast Baltimaade õlleturul, suurematest tarbijamängudest ja reklaamikampaaniatest. Tabelid

Potchefstroom Electronic Law Journal/Potchefstroomse Elektroniese ...

African Journals Online (AJOL)

What Intellectual Property lawyers can Learn from Barbra Streisand, Sepp Blatter, and the "Coca-Cola Cry-Baby": Dealing with "Trademark Bullying" in South Africa · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. AM Louw, 1-42. http://dx.doi.org/10.4314/pelj.v16i5.1 ...

Lääne-Virumaa ettevõtete TOP aastal 2004

Index Scriptorium Estoniae

2005-01-01

Tabelid: Lääne-Virumaa ettevõtete TOP 50; Käibe TOP 35; Kasumi TOP 35; Lääne-Virumaa ettevõtete üld- ja finantsandmed; Käibe kasvu TOP 20; Kasumi kasvu TOP 20; Rentaabluse TOP 20; Omakapitali tootlikkuse TOP 20. Vt. samas: Viktor Sepp, Merike Lees. Lääne-Virumaal üllatavad uued tegijad

Konkurss eesti-oma-kuub

Index Scriptorium Estoniae

2008-01-01

ERKL konkursist "Eesti oma kuub", kus I preemia pälvisid M. Kalle valmistatud jakk ja J. Saare mantel. II-IV kohta jagasid K. Sepp, I. Antson ja R. Vilusaar. Eripreemiad pälvisid: K. Nurk (kõige novaatorlikum töö), K. Loite (kõige ootamatum lahendus), U. Kangro ja M. Sims (parim lastetöö)

The Utility of the Metacognitive Awareness Inventory for Teachers among In-Service Teachers

Science.gov (United States)

Kallio, Heli; Virta, Kalle; Kallio, Manne; Virta, Arja; Hjardemaal, Finn Rudolf; Sandven, Jostein

2017-01-01

The purpose of the present study is to explore the utility of the compressed version of the Metacognitive Awareness Inventory for Teachers (MAIT-18) among in-service teachers. Knowledge of teachers' awareness of metacognition is required to support students' self-regulation, with the aim of establishing modern learning methods and life-long…

432 püksipaari Riia kongresside palee fassaadil / Lauri Kärk

Index Scriptorium Estoniae

Kärk, Lauri, 1954-

2000-01-01

Filmifestivalil "Arsenals" sai parima režissööri kujukese Mait Laas nukufilmi "Teekond Nirvaanasse" eest, teise koha preemia Valentin Kuigi mängufilm "Lurjus" ja Riho Undi nukufilm "Saamuel internetis". Peaauhinna andis loos shoti naisrežissööri Lynne Ramsay mängufilmile "Rotipüüdja" ("Ratcatcher")

Sinikael jätab jälgi / Tristan Priimägi

Index Scriptorium Estoniae

Priimägi, Tristan, 1976-

2002-01-01

Mängufilm "Agent Sinikael" : stsenaristid Marko Raat ja Andres Maimik : režissöör Marko Raat : operaator Arko Okk : helilooja Janek Murd : kunstnikud Margus Tammik ja Jaana Jüris : nimiosas Mait Malmsten : produtsendid Peeter Urbla ja Veiko Õunapuu : Exitfilm ja Suhkur Film, 2002. Lisatud Marko Raati filmograafia lk. 103

Lastemuuseum Miia-Milla-Manda = The Miia-Milla-Manda Children's Museum / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinnas Koidula 21A asuva hoone restaureerimisest, lastemuuseumi sisekujundusest. Kadrioru Lastepargi paviljoni (arhitekt Villem Seidra, 1937) renoveerimisprojekti tegi arhitekt Katrin Etverk, sisearhitektid ja ekspositsiooni kujundus: Maile Grünberg, Eliina Grünberg (Grünberg oü). Ajaloolane Aleksandr Pantelejev. Žürii liikme Mait Summataveti hinnang kultuurkapitali aastapreemiale esitatud hoonele

Tudengite nappus seab kõrgkoolid raskustesse / Madis Filippov

Index Scriptorium Estoniae

Filippov, Madis

2008-01-01

Gümnasistide arvu vähenemine nõuab kõrgkoolide töö ümberhindamist. Arvamust avaldavad Tallinna Ülikooli rektor Rein Raud, Tartu Ülikooli rektor Alar Karis, Eesti Maaülikooli rektor Mait Klaassen, Euroülikooli rektor Jüri Martin, Estonian Business Schooli rektor Peeter Kross ja haridusminister Tõnis Lukas

Karmid mängud / Kristel Raesaar

Index Scriptorium Estoniae

Raesaar, Kristel

2000-01-01

Tüli puiduärimehega maksis Hansapangale üle 100 miljoni. Lisa: ühed faktid, mitu tõlgendust - Hansapanga kreedidirektor Aivar Rehe, ECT tegevjuhi Arvi Schilfi ja laenu varjamises süüdistatud Hansapanga endise väliskaubanduse finantseerimise osak. juhataja Mait Kolditsa nägemus ECT laenuraha kadumisega seotud sündmustest

Prof. Tiina Kirsi raamatuesitlus Toronto Ülikoolis : uus ingliskeelne raamat eesti naiste elulugudest / Eda Sepp ; fotod: Eda Sepp

Index Scriptorium Estoniae

Sepp, Eda

2004-01-01

20. mail 2004 toimus Toronto Ülikooli Eesti Õppetooli juures Tiina Ann Kirsi toimetatud ja Tartu Ülikooli väljaandena 2004. a. ilmunud raamatu "She who remembers survives : interpreting Estonian women's post-soviet life stories" esitlus, kus toimetaja andis põhjaliku ülevaate teose olemusest ning eesmärkidest

Saagu valgus / Karin Tarto

Index Scriptorium Estoniae

Paulus, Karin, 1975-

1998-01-01

Eesti valgustikujundajatest ja valgustitest. Kas eesti disaineritel on õnnestunud leida oma nišš lambiletil. Tootjatest : OÜ "Raunto", AS "Titanus" (disaineriks Eestis elav rootslane Renni Par)-, Norrast pärineva kontserni "Glamox" tehasest Keilas, "Estoplastist" (disainerid Martin Pärn, Raido Laasing), AS "Steel Line". Valgustikujundajatest Tarmo Luisust, Aleksander Jakovlevist, Raivo Pristolist, Mait Summatavetist, Tõnis Vellamast

Põlvas näeb Ove Mustingu filmi / Tiia Allas

Index Scriptorium Estoniae

Allas, Tiia

2006-01-01

8. jaan. linastub Põlva kultuurikeskuses lühimängufilm "Vanameeste paradiis" : stsenaristid Ove Musting (ka idee autor), Urmas Lennuk : režissöör Ove Musting : operaator Mait Mäekivi : helilooja Arian Levin : kunstnik Eva-Marina Gramanovski : näitlejad Tõnu Aav, Aleksander Eelmaa, Tõnu Oja, Ants Ander, Henry Kõrvits : Downtown Pictures 2005

Multifilm kui tõsine asi / Marko Mägi

Index Scriptorium Estoniae

Mägi, Marko

1998-01-01

Esilinastus 6 animafilmi : "Vares ja hiired", autorid Priit Tender ja Mikk Rand; "Just märried", autor Peep Pedmanson; "Päevavalgus", autor Mait Laas; "Tom ja Fluffy", režissöörid Janno Põldma ja Heiki Ernits; "Bermuda", autor Ülo Pikkov; "Primavera", režissöörid Riho Unt ja Hardi Volmer

Eesti animafilme igale maitsele / Sulev Teinemaa

Index Scriptorium Estoniae

Teinemaa, Sulev, 1947-

1998-01-01

Esilinastus 6 animafilmi : "Vares ja hiired", autorid Priit Tender ja Mikk Rand; "Just märried", autor Peep Pedmanson; "Päevavalgus", autor Mait Laas; "Tom ja Fluffy", režissöörid Janno Põldma ja Heiki Ernits; "Bermuda", autor Ülo Pikkov; "Primavera", režissöörid Riho Unt ja Hardi Volmer

Aimdusi tsivilisatsioonist / Tarmo Teder

Index Scriptorium Estoniae

Teder, Tarmo, 1958-

1998-01-01

Esilinastus 6 animafilmi : "Vares ja hiired", autorid Priit Tender ja Mikk Rand; "Just märried", autor Peep Pedmanson; "Päevavalgus", autor Mait Laas; "Tom ja Fluffy", režissöörid Janno Põldma ja Heiki Ernits; "Bermuda", autor Ülo Pikkov; "Primavera", režissöörid Riho Unt ja Hardi Volmer

Animaalselt ja humaanselt / Karlo Funk

Index Scriptorium Estoniae

Funk, Karlo, 1971-

1998-01-01

Esilinastus 6 animafilmi : "Vares ja hiired", autorid Priit Tender ja Mikk Rand; "Just märried", autor Peep Pedmanson; "Päevavalgus", autor Mait Laas; "Tom ja Fluffy", režissöörid Janno Põldma ja Heiki Ernits; "Bermuda", autor Ülo Pikkov; "Primavera", režissöörid Riho Unt ja Hardi Volmer

Herbert Johansoni eeskujulikud koolimajad / Mait Väljas

Index Scriptorium Estoniae

Väljas, Mait

2010-01-01

Eesti arhitektuurimuuseumis eksponeeritava Herbert Johansoni (1884–1964) ja Eugen Habermanni (1884–1944) juubelinäituse taustal on kohane rääkida koolimajadest. Johansoni kontol on suur osa Tallinna sõdadevahelistest koolimajadest, kaks lasteaeda ja üks kutsekool

MAIT cells: new guardians of the liver

OpenAIRE

Kurioka, Ayako; Walker, Lucy J; Klenerman, Paul; Willberg, Christian B

2016-01-01

The liver is an important immunological organ that remains sterile and tolerogenic in homeostasis, despite continual exposure to non-self food and microbial-derived products from the gut. However, where intestinal mucosal defenses are breached or in the presence of a systemic infection, the liver acts as a second 'firewall', because of its enrichment with innate effector cells able to rapidly respond to infections or tissue dysregulation. One of the largest populations of T cells within the h...

Suomi-englanti-suomi taskusanakirja gastroenterologisen osaston sairaanhoitajille

OpenAIRE

Seppä, Maija; Ollilainen, Pauliina

2013-01-01

Ollilainen, Pauliina & Seppä, Maija. Suomi-englanti-suomi-taskusanakirja gastroenterologisen osaston sairaanhoitajille, Helsinki, syksy 2013, 57 s., liitteitä 2 Diakonia-ammattikorkeakoulu, Terveysalan koulutusohjelma, terveydenhoitaja/sairaanhoitaja. Opinnäytetyön tarkoituksena oli tuottaa helppokäyttöinen taskusanakirja helpottamaan potilaan ja hoitajan kommunikointia gastroenterologisella osastolla. Sanakirjan avulla hoitajien ja potilaiden välinen kommunikointi paranee, jolloin myös ...

Peep Aaviksoo kukutas EMT-kesksus / Jaan Männik ; interv. Vallo Toomet

Index Scriptorium Estoniae

Männik, Jaan, 1945-

2003-01-01

EMT nõukogu esimees ja Eesti Telekomi juhatuse esimees Jaan Männik vastab küsimustele, mis on seotud Peep Aaviksoo lahkumisega Eesti Mobiiltelefoni juhi kohalt. Vt. samas: Aaviksoo selgitab lahkumise põhjusi. Peep Aaviksoo kiri. Kommenteerivad Radiolinja Eesti juhatuse esimees Sami Seppänen, Tele2 Eesti juhatuse esimees Üllar Jaaksoo, Ühispanga analüütik Sven Kunsing

Kelle rahanõuandeid kuulate ja kasutate?

Index Scriptorium Estoniae

2005-01-01

Küsimusele vastavad vabakutseline kirjanik Kadri Kõusaar, Riigikogu liige Andres Lipstok, TTÜ üliõpilasesinduse juhatuse esimees Heiki Lemba, IM Arvutite sekretär-raamatupidaja Silja Kalda, Vain SMD konsultant ja koolitaja Urmas Purde, energeetik Peeter Saeraas, Euro Painting and Restoration juht Brian Sepp, Mercuri Urval konsultant Tarmo Müürsepp, Regio osakonnajuhataja Gerri Kodres, OÜ Vastus juht Jelena Rootamm-Valter

Me võime liigutada tooli / Kristina Pai

Index Scriptorium Estoniae

Pai, Kristina, 1967-

2014-01-01

Põhja- ja Baltimaade raamatukoguhoidjate kohtumisest 2013. aasta septembris Helsingis jagasid muljeid Toila raamatukogu juhataja Lea Rand, Viljandi Linnaraamatukogu lugemissaalide juhataja Veronika Raudsepp-Linnupuu, Lääne Maakonna Keskraamatukogu direktor Ilme Sepp, Võrumaa Keskraamatukogu direktor Inga Kuljus, ERÜ esimees Katre Riisalu, Tallinna Keskraamatukogu direktor Kaie Holm, Tartu Linnaraamatukogu spetsialist Maia Tammjärv, Lääne-Virumaa Keskraamatukogu direktor Kaili Õunapuu-Seidelberg

The President and the Intelligence Community: The Importance of the Relationship

Science.gov (United States)

2017-12-01

Intelligence Successes and Failures in Operations Desert Shield/Storm, (Washington, DC: Government Printing Office, 1993), 2–3, http://www.dtic.mil... Intelligence as Leaders of the U.S. Intelligence Community 1946–2005. Washington, D.C.: Government Printing Office, 2005. Hedley, John Hollister...THE INTELLIGENCE COMMUNITY: THE IMPORTANCE OF THE RELATIONSHIP by Dane M. Holtmeyer December 2017 Thesis Advisor: Kalev I. Sepp

Journal of Genetics | Indian Academy of Sciences

Indian Academy of Sciences (India)

TIMP2 gene polymorphisms are associated with hypertension in patients with myocardial infarction. José Manuel Rodríguez-Pérez Nancy Martínez-Rodríguez Gilberto Vargas-Alarcón Maite Vallejo Irma Eloisa Monroy-Muñoz Carlos Posadas-Romero Eric Kimura-Hayama Teresa Juárez-Cedillo José Manuel Fragoso ...

Nukufilmi erootika / Jaan Ruus

Index Scriptorium Estoniae

Ruus, Jaan, 1938-2017

2005-01-01

Kaks eesti nukufilmi - "Laud" : autorid Jelena Girlin ning Mari-Liis Bassovskaja : operaator ja kaasrežissöör Urmas Jõemees : helilooja Malle Maltis : Nukufilm OÜ 2004 ja "Generatio" : stsenarist, kunstnik ja režissöör Mait Laas : konsultant Paavo Matsin : operaatorid Ragnar Neljandi, Raivo Möllits : helilooja Tiit Kikas : Nukufilm OÜ - Icon Film (Saksamaa) 2005

Animatsiooni vastu ei saa ükski / Mikk Rand

Index Scriptorium Estoniae

Rand, Mikk, 1970-

1998-01-01

21.5. esilinastuvad kinos "Sõprus" 6 animafilmi : "Vares ja hiired", autorid Priit Tender ja Mikk Rand; "Just märried", autor Peep Pedmanson; "Päevavalgus", autor Mait Laas; "Tom ja Fluffy", režissöörid Janno Põldma ja Heiki Ernits; "Bermuda", autor Ülo Pikkov; "Primavera", režissöörid Riho Unt ja Hardi Volmer

Esilinastuvad eesti animafilmid

Index Scriptorium Estoniae

1998-01-01

21.5. esilinastuvad kinos "Sõprus" 6 animafilmi : "Vares ja hiired", autorid Priit Tender ja Mikk Rand; "Just märried", autor Peep Pedmanson; "Päevavalgus", autor Mait Laas; "Tom ja Fluffy", režissöörid Janno Põldma ja Heiki Ernits; "Bermuda", autor Ülo Pikkov; "Primavera", režissöörid Riho Unt ja Hardi Volmer

Kuus uut Eesti filmi korraga ekraanil / Tarmo Teder

Index Scriptorium Estoniae

Teder, Tarmo, 1958-

1998-01-01

21.5. esilinastuvad kinos "Sõprus" 6 animafilmi : "Vares ja hiired", autorid Priit Tender ja Mikk Rand; "Just märried", autor Peep Pedmanson; "Päevavalgus", autor Mait Laas; "Tom ja Fluffy", režissöörid Janno Põldma ja Heiki Ernits; "Bermuda", autor Ülo Pikkov; "Primavera", režissöörid Riho Unt ja Hardi Volmer

Sundosaõigus ja tagasivõitmine / Katrin Sepp

Index Scriptorium Estoniae

Sepp, Katrin

2017-01-01

Sundosa mõistest ja sundosa saajatest. Sihtasutusse paigutatud vara arvesse võtmisest sundosa suuruse määramisel, sundosaõigusest tulenevatest nõudetest sihtasutuse vastu ja rahvusvahelistest pärimisasjadest

Sisearhitektuuri uudised / Aino Ingrid Sepp, Aale Kask

Index Scriptorium Estoniae

Sepp, Aino Ingrid

2006-01-01

Restoran Vertigo Tallinnas, sisekujundus Janno Roos ja Andres Labi; ööklubi Tartus Ülikooli tänava kaubanduskeskuse hoones, sisekujundus Riin Pettai ja Kerli Lepp; ilusalong Medemis Tallinnas, sisekujundus Maris Kerge; tantsustuudio Stiletto endises Marati tootmishoones Tallinnas, sisekujundus Anneli Ahi

Sisearhitektuuri uudised / Aino Ingrid Sepp, Aale Kask

Index Scriptorium Estoniae

Sepp, Aino Ingrid

2007-01-01

Tallinnas lillesalongi Masha sisekujunduse autorid on Ahti Lyra ja Kristiine Lõuk. Pärnu ööklubi Str sisekujunduse autor on Hannes Praks. Tallinna Viru keskuse avatud baari sisekujunduse autorid on Kärt Villmann ja Andres Rohtla

Puit linnas - väikevormid / Urmas Oja

Index Scriptorium Estoniae

Oja, Urmas, 1981-2012

2005-01-01

Tartu Rüütli t. uus kujundus (Rene Valner, Margus Maiste, Ott Kadarik), Vallimäe trepp Rakveres (Siiri Vallner, Heidi Urb, AB Kavakava), Helsingi Tehnikakõrgkooli üliõpilaste Antti Lehto ja Teemu Seppäneni töö Helsindi disaininädala infopaviljoni konkursil, park ja aiamööbel (Nathalie Dubois, Mustapha Sanaoui) kortermajade hoovis Prantsusmaal. 8 värv. ill

Marta maailm / Marta Vaarik

Index Scriptorium Estoniae

Vaarik, Marta, 1987-

2007-01-01

Riigikogu liige Evelin Sepp käis sir Elton Johni kontserdil 15. sept. Saku Suurhallis. Poplaulja Mike Emelai on kaalus alla võtnud. Riigikogu liige Enn Eesmaa esineb Cliff Richardi looga "Don't Forget To Catch Me" 4. okt. Eesti Vähiliidu korraldataval heategevuskontserdil. "Tantsud tähtedega" saates paarina võistlevad laulja Koit Toome ja tantsija Kerttu Tänav käisid Elton Johni kontserdil

Glutathione enzyme and selenoprotein polymorphisms associate with mercury biomarker levels in Michigan dental professionals

Energy Technology Data Exchange (ETDEWEB)

Goodrich, Jaclyn M.; Wang, Yi [Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109 (United States); Gillespie, Brenda [Department of Biostatistics, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109 (United States); Werner, Robert [Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109 (United States); Department of Physical Medicine and Rehabilitation, University of Michigan, 325 E. Eisenhower Parkway Suite 100, Ann Arbor, MI 48108 (United States); Franzblau, Alfred [Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109 (United States); Basu, Niladri, E-mail: niladri@umich.edu [Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109 (United States)

2011-12-15

Mercury is a potent toxicant of concern to both the general public and occupationally exposed workers (e.g., dentists). Recent studies suggest that several genes mediating the toxicokinetics of mercury are polymorphic in humans and may influence inter-individual variability in mercury accumulation. This work hypothesizes that polymorphisms in key glutathione synthesizing enzyme, glutathione s-transferase, and selenoprotein genes underlie inter-individual differences in mercury body burden as assessed by analytical mercury measurement in urine and hair, biomarkers of elemental mercury and methylmercury, respectively. Urine and hair samples were collected from a population of dental professionals (n = 515), and total mercury content was measured. Average urine (1.06 {+-} 1.24 ug/L) and hair mercury levels (0.49 {+-} 0.63 ug/g) were similar to national U.S. population averages. Taqman assays were used to genotype DNA from buccal swab samples at 15 polymorphic sites in genes implicated in mercury metabolism. Linear regression modeling assessed the ability of polymorphisms to modify the relationship between mercury biomarker levels and exposure sources (e.g., amalgams, fish consumption). Five polymorphisms were significantly associated with urine mercury levels (GSTT1 deletion), hair mercury levels (GSTP1-105, GSTP1-114, GSS 5 Prime ), or both (SEPP1 3 Prime UTR). Overall, this study suggests that polymorphisms in selenoproteins and glutathione-related genes may influence elimination of mercury in the urine and hair or mercury retention following exposures to elemental mercury (via dental amalgams) and methylmercury (via fish consumption). -- Highlights: Black-Right-Pointing-Pointer We explore the influence of 15 polymorphisms on urine and hair Hg levels. Black-Right-Pointing-Pointer Urine and hair Hg levels in dental professionals were similar to the US population. Black-Right-Pointing-Pointer GSTT1 and SEPP1 polymorphisms associated with urine Hg levels. Black

Glutathione enzyme and selenoprotein polymorphisms associate with mercury biomarker levels in Michigan dental professionals

International Nuclear Information System (INIS)

Goodrich, Jaclyn M.; Wang, Yi; Gillespie, Brenda; Werner, Robert; Franzblau, Alfred; Basu, Niladri

2011-01-01

Mercury is a potent toxicant of concern to both the general public and occupationally exposed workers (e.g., dentists). Recent studies suggest that several genes mediating the toxicokinetics of mercury are polymorphic in humans and may influence inter-individual variability in mercury accumulation. This work hypothesizes that polymorphisms in key glutathione synthesizing enzyme, glutathione s-transferase, and selenoprotein genes underlie inter-individual differences in mercury body burden as assessed by analytical mercury measurement in urine and hair, biomarkers of elemental mercury and methylmercury, respectively. Urine and hair samples were collected from a population of dental professionals (n = 515), and total mercury content was measured. Average urine (1.06 ± 1.24 ug/L) and hair mercury levels (0.49 ± 0.63 ug/g) were similar to national U.S. population averages. Taqman assays were used to genotype DNA from buccal swab samples at 15 polymorphic sites in genes implicated in mercury metabolism. Linear regression modeling assessed the ability of polymorphisms to modify the relationship between mercury biomarker levels and exposure sources (e.g., amalgams, fish consumption). Five polymorphisms were significantly associated with urine mercury levels (GSTT1 deletion), hair mercury levels (GSTP1-105, GSTP1-114, GSS 5′), or both (SEPP1 3′UTR). Overall, this study suggests that polymorphisms in selenoproteins and glutathione-related genes may influence elimination of mercury in the urine and hair or mercury retention following exposures to elemental mercury (via dental amalgams) and methylmercury (via fish consumption). -- Highlights: ► We explore the influence of 15 polymorphisms on urine and hair Hg levels. ► Urine and hair Hg levels in dental professionals were similar to the US population. ► GSTT1 and SEPP1 polymorphisms associated with urine Hg levels. ► Accumulation of Hg in hair following exposure from fish was modified by genotype. ► GSTP1, GSS

Short outlines of books by Estonian authors : [annotations] / Rutt Hinrikus, Janika Kronberg

Index Scriptorium Estoniae

Hinrikus, Rutt, 1946-

1999-01-01

Ehin, Andres. Seljatas sada meest; Ilmet, Peep. Tuuldunud luule; Kaplinski, Jaan. Öölinnud. Öömõtted; Kender, Kaur. Iseseisvuspäev; Kesküla, Kalev. Vabariigi laulud; Luik, Viivi. Maa taevas; Nõu, Helga. Hundi silmas; Raun, Mait. Wake up; Remsu, Olev. Haapsalu tragöödia; Sauter, Peeter. Kogu moos; Undusk, Jaan. Maagiline müstiline keel; Vint, Toomas. Kunstnikuromaan

Kodumaine multifilm õilmitseb / Mart Rummo

Index Scriptorium Estoniae

Rummo, Mart

2001-01-01

Tähistamaks eesti animafilmi 70. aastapäeva näidatakse täna Kinomajas kuut uut multifilmi : 13-osaline lamenukkfilm "Tulelaeva kulid" (režissöör Mait Laas), Ülo Pikkovi kaks joonisfilmi "Superlove" ja "Peata ratsanik", Priit Tenderi joonisfilm "Mont Blanc", Kaspar Jancise joonisfilm "Romanss" ja Janno Põldma - Heiki Ernitsa laste joonisfilmiseriaali "Lepatriinude jõulud" 5-min. trailer

Vabaduse väljak = The first design stage of Freedom Square / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinna Vabaduse väljakust, mis pälvis Eesti Kultuurkapitali 2009. aasta aastapreemia uue kvaliteedi eest Eesti linnaehituses ja avaliku ruumi loomisel. Arhitektid: Andres Alver, Veljo Kaasik, Tiit Trummal, kaasautorid Indrek Rünkla, Tarmo Laht, Sven Koppel, Ulla Saar, Toomas Tammis (Alver Arhitektid OÜ). Ajaloolane Rein Zobel. Žürii liikmete Kalle Komissarovi ja Mait Summataveti hinnang väljakule

Tjoplõi dozhd v zale suda / Boris Tuch

Index Scriptorium Estoniae

Tuch, Boris, 1946-

2006-01-01

Mängufilm "Meeletu" : stsenaristid Jaan Tätte, Elmo Nüganen : režissöör Elmo Nüganen : operaator Mait Mäekivi : produtsent Kristian Taska : helilooja Jaak Jürisson : peaosas Rain Simmul : Taska Film - Eesti Televisioon 2006. Võrreldakse näidendi lavastust ja filmi. Arvustuses on Jüri osatäitjaks ekslikult nimetatud lavastuse osatäitjat Allan Noormetsa ( tegelikult Aivar Tommingas)

Suur esilinastamine

Index Scriptorium Estoniae

1998-01-01

21.5. esilinastuvad kinos "Sõprus" 6 animafilmi : "Vares ja hiired", autorid Priit Tender ja Mikk Rand; "Just märried", autor Peep Pedmanson; "Päevavalgus", autor Mait Laas; "Tom ja Fluffy", režissöörid Janno Põldma ja Heiki Ernits; "Bermuda", autor Ülo Pikkov; "Primavera", režissöörid Riho Unt ja Hardi Volmer. Aut. : M.R

Diethylstilbestrol (DES)-stimulated hormonal toxicity is mediated by ERα alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle.

Science.gov (United States)

Li, Yin; Hamilton, Katherine J; Lai, Anne Y; Burns, Katherine A; Li, Leping; Wade, Paul A; Korach, Kenneth S

2014-03-01

Diethylstilbestrol (DES) is a synthetic estrogen associated with adverse effects on reproductive organs. DES-induced toxicity of the mouse seminal vesicle (SV) is mediated by estrogen receptor α (ERα), which alters expression of seminal vesicle secretory protein IV (Svs4) and lactoferrin (Ltf) genes. We examined a role for nuclear receptor activity in association with DNA methylation and altered gene expression. We used the neonatal DES exposure mouse model to examine DNA methylation patterns via bisulfite conversion sequencing in SVs of wild-type (WT) and ERα-knockout (αERKO) mice. The DNA methylation status at four specific CpGs (-160, -237, -306, and -367) in the Svs4 gene promoter changed during mouse development from methylated to unmethylated, and DES prevented this change at 10 weeks of age in WT SV. At two specific CpGs (-449 and -459) of the Ltf gene promoter, DES altered the methylation status from methylated to unmethylated. Alterations in DNA methylation of Svs4 and Ltf were not observed in αERKO SVs, suggesting that changes of methylation status at these CpGs are ERα dependent. The methylation status was associated with the level of gene expression. In addition, gene expression of three epigenetic modifiers-DNMT3A, MBD2, and HDAC2-increased in the SV of DES-exposed WT mice. DES-induced hormonal toxicity resulted from altered gene expression of Svs4 and Ltf associated with changes in DNA methylation that were mediated by ERα. Alterations in gene expression of DNMT3A, MBD2, and HDAC2 in DES-exposed male mice may be involved in mediating the changes in methylation status in the SV. Li Y, Hamilton KJ, Lai AY, Burns KA, Li L, Wade PA, Korach KS. 2014. Diethylstilbestrol (DES)-stimulated hormonal toxicity is mediated by ERα alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle. Environ Health Perspect 122:262-268; http://dx.doi.org/10.1289/ehp.1307351.

Saadikud annavad aru, kas ja kuidas nende palga kallale minna

Index Scriptorium Estoniae

2008-01-01

Ilmunud ka: Postimees : na russkom jazõke 12. märts lk. 2. Riigikogu liikmete vastused küsimustele palga suuruse ja palgasüsteemi muutmise kohta. Lisa: Seisukohti jaganud riigikogulased. Postimees : na russkom jazõke küsimustele vastavad: Villu Reiljan, Jürgen Ligi, Imre Sooäär, Tatjana Muravjova, Evelyn Sepp, Olga Sõtnik, Vladimir Vellman, Jüri Tamm, Peeter Kreitzberg, Aleksei Lotman, Toomas Tõniste, Mart Nutt

Palmse supelmaja taas kasutusel / Anneliis Aunapuu

Index Scriptorium Estoniae

Aunapuu, Anneliis

1998-01-01

Lahemaa Rahvuspark rentis poolelioleva supelmaja perekond Ong'ile, kes ehituse lõpetas, hoone sisustas ja avas kohvik-restorani 'Freifrau Isabella'. Sisekujundus autor Leila Pärtelpoeg nimetab sisekujundust palladiaanlikuks. Tänu AEL ja Tartu Kunstikooliga sõlmitud lepingule sai supelmaja kõrgetasemelise maalritöö. Maalingud eesruumis ئ Eve Erman. Sepisvalgustid ئ Ülo Sepp. Pika-laua-saalis oleva von Pahlenite vapi valmistas Andres Sapar. Inkrusteeritud puhvetkapi taastas Urmas Ong.

Plaadid / Mait Eelrand, Toomas Puna, Veiko Pesur...[jt.

Index Scriptorium Estoniae

2007-01-01

Uutest heliplaatidest Wolf & Cub "Vessels", Karl MAdis & Karavan "Taevalik meloodia ئ Nat King Cole'i laule", Sophie Ellis-Bextor "Trip The Light Fantastic", Him "Uneasy Listening 1&2", Kognito "Muutuv"

Katse portreteerida nõukogude kosmosemaja / Mait Väljas

Index Scriptorium Estoniae

Väljas, Mait

2011-01-01

Prantsuse fotograafist Frédéric Chaubinist, kes pildistas NSV Liidus 1975.-1990. a. ehitatud eripäraseid hooneid, korraldas fotonäitusi. F. Chaubini raamatust "СССР : cosmic communist constructions photographed" (Köln : Taschen, 2011), raamatusse jõudnud eesti arhitektuurist

Rotermanni soolalao urbanistliku pargi ideekonkurss / Mait Väljas

Index Scriptorium Estoniae

Väljas, Mait

2009-01-01

Eesti Arhitektuurimuuseumi korraldatud avalikust konkursist, Ignar Fjuki koostatud võistlustingimustest, premeeritud töödest. 1. preemia sai töö "Piazza", autor Villem Tomiste, (AB Kosmos)), 2. preemia töö "Muesuum", autor Ott Kadarik, (AB Kosmos), 3. preemia töö "Arhitektuuri allee", autor Jürgen Lepper, (AB Dimensioon). Anti välja üks ergutuspreemia, ära märgiti kaks tööd

Teadusmõtte ja teaduse mineviku lood / Mait Talts

Index Scriptorium Estoniae

Talts, Mait, 1964-

2011-01-01

Arvustus: Baltic Journal of European Studies. Selected papers of the 24th International Baltic Conference on the history of science and the follow-up seminar (2011, nr. 1). Tallinn : Tallinn University of Technology, 2011

Evaluation of European District Heating Systems for Application to Army Installations in the United States

Science.gov (United States)

2006-07-01

of the conurbation, the effectiveness of the investments as well as the plant’s management and the owner’s return requirements ( Energia 2004...37 p. Design Manual of ThermoNet Systems. 32 p. (In Finnish). ECONET Manual. 2005. Fläktwoods. Energia 2004. Energy year 2004. “District Heating...Pulliainen, K. 2005. Helsingin Energia . Oral source. Seppänen, O. 1995. ISBN 951-97233-1-5. Heating of Buildings. Publisher Suomen LVI- yhdistyken

Carnitine prevents the early mitochondrial damage induced by methylglyoxal bis(guanylhydrazone) in L1210 leukaemia cells.

OpenAIRE

Nikula, P; Ruohola, H; Alhonen-Hongisto, L; Jänne, J

1985-01-01

We previously found that the anti-cancer drug methylglyoxal bis(guanylhydrazone) (mitoguazone) depresses carnitine-dependent oxidation of long-chain fatty acids in cultured mouse leukaemia cells [Nikula, Alhonen-Hongisto, Seppänen & Jänne (1984) Biochem. Biophys. Res. Commun. 120, 9-14]. We have now investigated whether carnitine also influences the development of the well-known mitochondrial damage produced by the drug in L1210 leukaemia cells. Palmitate oxidation was distinctly inhibited in...

Homsed disaini- ja furnituurilahendused

Index Scriptorium Estoniae

2007-01-01

Müügijuht Galina Sepp 2006. a. asutatud mööbliettevõttest AIS Furniture (Advanced Interior Solutions), mille tootmistsehh asub Harjumaal Loo alevikus, salong Tallinnas Pärnu mnt. 66. Toodetakse eritellimusel mööblit kööki, elu- ja vannituppa, garderoobi, büroosse ning abiruumidesse. AIS Furniture disaineritelt saab tellida kogu maja või korteri sisekujunduse koos mööbliga. Köökide tehnilised lahendused on pärit furnituuritootjatelt

Loengud seaduseelnõude koostajaile / Margit Kikas

Index Scriptorium Estoniae

Kikas, Margit

2004-01-01

Eesti Juristide Liidu poolt koostöös Riigikantselei ja Justiitsministeeriumiga korraldatud loengusarjast: Õigusloome ja normitehnika: areng ja probleemid. Sõnavõtjad loengutel: Raul Narits, Katre Kont-Kontson, Lauri Mälksoo, Raigo Sõlg, Jüri Heinla, Anno Aedmaa, Aare Kasemets, Juhani Lemmik, Ülo Siivelt, Külli Koit, Aare Reenumägi, Mall Gramberg, Toomas Sepp, Julia Laffranque, Kristel Aguraiuja, Aime Vettik, Hille Saluäär, Hiie Tamm, Kristina Nõgols, Eve Randvere

10.-14. II on Puhta Rõõmu alaliiduna tuntud...

Index Scriptorium Estoniae

2004-01-01

Lõkerdus- ja tegevuskunstikollektiiv Naeruorgesster ehk Laffing ahkestra - dirigent Erki Kannus, lõkerdajad Ivika Kivi, Piret Räni, Merle Kannus, Maris Mändel, Marge Monko, Aino Sepp, Annika Kaljurand, Anya Ronacher - esines 11. II Stockholmis Moderna Museeti taasavamispidustuste raames, 12. II osaleti tegevuskunstiprogrammis "Source Live 2004". Aprillis oodatakse kollektiivi Varssavisse Zacheta galerii näitusele "Poisid ja tüdrukud" (16. II-4. IV), kus esitatakse Piret Räni ja Anu Vahtra videot "Punk.Fem.Collection"

Tallinlased kostitavad Euroopa filmitähti / Andreas Sepp

Index Scriptorium Estoniae

Sepp, Andreas

2010-01-01

Eesti-poolne korraldaja Ave Ungro projektist "Kino kiikab kööki", mille raames kostitavad Tallinna kodud Euroopa Filmiakadeemia gala külalisi. EFA külalist võõrustavast kunstnik Andres Lõost ja kino "Sõprus" loovjuhist Tiina Savist

Baltic cooperation vs Visegrad cooperation (essay) / Tanel Sepp

Index Scriptorium Estoniae

Sepp, Tanel

2004-01-01

Baltimaade ning Visegrad grupi riikide (Poola, Ungari, Tšehhi, Slovakkia) arengust NSV Liidu mõjusfääris olevatest piirkondadest iseseisvateks riikideks, koostööst Euroopa Liidu ja NATO kontekstis

Olla originaalne ja tähelepandud / Eve Sepp

Index Scriptorium Estoniae

Sepp, Eve

1989-01-01

Tuntud daamide originaalehetest - tekstiilikunstnik Anna Gerretzi Ülle Kõutsi valmistatud kõrvarõngad, disainer Helle Gansi Katrin Amose loodud rinnanõel, raamatukogudirektrissi Anne Randeli Tiina Käeseli loodud ehted, arhitekt Marka Lõokese Kadri Mälgu loodud komplekt, kunstiteadlase Krista Kodrese Tiina Käeseli loodud komplekt, grimeerija Krista Pärdi abikaasa Rein Metsa loodud ehted

Antibiootikumide kasutamise olukord Euroopas sai avalikuks / Janne Sepp

Index Scriptorium Estoniae

Sepp, Janne

2013-01-01

Üle-euroopalisest antibiootikumide kasutamise andmete kogumise projektist ESAC, mille eesmärgiks peale usaldusväärsete ja võrreldavate andmete kogumise on ka tähelepanu juhtimine antibiootikumiresistentsuse probleemile

Diivanil hüppamine lubatud! / Aino Ingrid Sepp

Index Scriptorium Estoniae

Sepp, Aino Ingrid

2008-01-01

Viietoaline stiilne ja lapsesõbralik korter Tallinna vanalinnas. Sisearhitekt Stina Marttinen, tema kommentaarid. Sisekujundus valmis 2008. aastal. Korterile annavad uue ilme Designers Guildi tekstiilid. Köögimööbli valmistas tellimustööna Eesti firma. 17 värv. vaadet

Ohtlikkuse arvestamine karistuse mõistmisel kohtupraktikas / Heili Sepp

Index Scriptorium Estoniae

Sepp, Heili, 1975-

2008-01-01

Karistusseadustiku tõlgendamisest ja kohtupraktikast karistuse mõistmisel. Artikkel põhineb ettekandel, mille autor pidas Jaan Sootaki 60. juubeli puhul toimunud teaduskonverentsil Tartus 19. sept. 2008

Eesti arengupotentsiaal ja institutsioonide roll / Jüri Sepp

Index Scriptorium Estoniae

Sepp, Jüri

2005-01-01

Analüüsist järeldus, et Eesti majanduse reaalne arengutase on vaatamata 15 aastat kestnud siirdele ning ühinemisele EL-iga üks Euroopa madalamaid, kuigi majanduse institutsionaalset keskkonda võib pidada nii konkurentsivõimet kui ka majanduskasvu soodustavaks. Tabelid. Diagramm. Skeemid

Jean Nouveli supermodernism Barcelonas / Raili Seppänen

Index Scriptorium Estoniae

Seppänen, Raili

2005-01-01

2005. a. suvel valmivast prantsuse arhitekti Jean Nouveli (sünd. 1945) projekteeritud tornmajast Torre Agbar Barcelonas Avinguda Diagonal 209-211. Abiks hispaania arhitekt Fermin Vazquez arhitektibüroost b720 Arquitectura S.L. Jean Nouveli tuntud projekte. Ill.: J. Nouveli portreefoto, tornmaja välisvaade

Estonian agriculture after accession : CAP impact / Mati Sepp

Index Scriptorium Estoniae

Sepp, Mati, 1945-

2003-01-01

Eesti on olnud üks liberaalsema hinna- ja väliskaubanduse korraldusega riike maailmas. Ühinemine ühtse põllumajanduspoliitikaga tähendab aga eelkõige kõrget interventsiooniastet toodete mahu ja hindade kujundamisel ning konservatiivset toiduainete väliskaubanduse korraldust. Tabelid. Graafikud. Diagrammid

Tori Hobune 2011 & Eesti Hobune 2011 / Krista Sepp

Index Scriptorium Estoniae

Sepp, Krista

2011-01-01

14. mail korraldas Tori Hobusekasvanduse ratsaspordiklubi XVI Tori hobuse päeva ja esimese ettapi karikasarjas Tori Hobune 2011, kus avastardi takistussõidus tegid ka eesti tõugu hobused, ning 15. mail toimus koolisõidu etapp

Natura pälvis maavalitsuse kriitikatule / Andres Sepp

Index Scriptorium Estoniae

Sepp, Andres, 1976-

2004-01-01

Maavalitsuse hinnangul tuleks Natura aladest välja jätta Suurde väina kavandatava püsiühenduse trassid ja Viirelaid, Küdema lahe äärde rajatava sadama detailplaneeringus käsitletud vee-ala ning faarvaater

Stipendiumiprogramm, mis suunatud stimuleerima noorte arengut / Viire Sepp

Index Scriptorium Estoniae

Sepp, Viire, 1955-

2014-01-01

Programmist, mis väärtustab reaalainete olümpiaade, kui võimekate noorte arengu üht olulist stiimulit. Tallinna Tehnikaülikooli üliõpilase Mette Purde, Harvardi ülikooli üliõpilase Erik Tamre, Cambridge'i ülikooli üliõpilase Jaan Tootsi ning Tartu Ülikooli üliõpilaste Janno Veeorg, Lona Liisa Sutt, Madis Ollikainen ja Jaagup Repän arvamused olümpiaadide olulisusest

Karl Menningu (ja iseenese) päästmiseks / Ants Hein

Index Scriptorium Estoniae

Hein, Ants, 1952-

2008-01-01

Vastuseks Karin Hallas-Murula arvustusele "Maja, mis on sümbol" (Sirp, 2007, 5. X, lk. 13) ja Mait Väljase arvustusele "Iseolemise algus arhitektuuris" (Maja, 2008, nr. 1, lk. 86-87) oma 2007. a. ilmunud raamatust "Maja kui sümbol : Eesti Üliõpilaste Seltsi hoone Tartus" kohta. Georg Hellati ja Karl Menningu osalusest EÜS-i hoone sünniloos. Frank Lloyd Wrightist kui võimalikust eeskujuandjast

Implicitly Defined Neural Networks for Sequence Labeling

Science.gov (United States)

2017-07-31

ularity has soared for the Long Short - Term Memory (LSTM) (Hochreiter and Schmidhuber, 1997) and vari- ants such as Gated Recurrent Unit (GRU) (Cho et...610. Sepp Hochreiter and Jürgen Schmidhuber. 1997. Long short - term memory . Neural computation 9(8):1735– 1780. Zhiheng Huang, Wei Xu, and Kai Yu. 2015...network are coupled together, in order to improve perfor- mance on complex, long -range dependencies in either direction of a sequence. We contrast our

Majaraamatud - ühtne tervik ja väärikalt hoitud detailid / Yoko Alender

Index Scriptorium Estoniae

Alender, Yoko, 1979-

2011-01-01

Tutvustus: Tallinna maja : hoonetüübi areng ja säästev uuendamine / koostanud Mark Sepp ja Tallinna Kultuuriväärtuste Amet. Tallinn, 2010; Lenderi maja : hoonetüübi areng ja säästev uuendamine / koostanud Anni Martin ja Tallinna Kultuuriväärtuste Amet. Tallinn, 2009; Funktsionalistlik maja : eramu ja väike kortermaja / koostanud Monika Eensalu ja Tallinna Kultuuriväärtuste Amet. Tallinn, 2011. Vanade majade säilitamisest

Radio Model-free Noise Reduction of Radio Transmissions with Convolutional Autoencoders

Science.gov (United States)

2016-09-01

as a front end to a long short term memory (LSTM) [12], which may provide another route towards understanding the content or meaning of RF emissions...Exploring Engineering™ (IJITEE) 2:6–9. 12. Sepp Hochreiter and Jurgen Schmidhuber. 1007. “Long Short - term Memory , Neural Computation 9(8):1735–1780. 13...the noisy channel capacity , with no further optimizations. 2 2. METHODS AND EXPERIMENT We will use the terms instance or example to refer to a

LAPSENA SEKSUAALISESTI HYVÄKSIKÄYTETTYJEN NAISTEN KOKEMUKSIA VOIMAANTUMISESTA : Elämän pituinen matka

OpenAIRE

Seppänen, Suvi

2011-01-01

Lapsena seksuaalisesti hyväksikäytettyjen naisten kokemuksia voimaantumisesta–Elämän pituinen matka. Opinnäytetyö, 64 sivua, liitteitä 5. Suvi Seppänen, Diakonia-ammattikorkeakoulu, Diak Pohjoinen, Oulu, syksy 2011. Hoitotyön koulutusohjelma, diakonisen hoitotyön suuntautumisvaihtoehto, sairaanhoitaja (AMK) – diakonissa. Suomen Delfins Ry on valtakunnallinen tukijärjestö seksuaalisesti hyväksikäytetyille ihmisille. Järjestön tukemia vertaistukiryhmiä toimii eri puolilla Suomea. Lupa tutki...

Eelmine aasta andis palju häid uusehitisi / Heli Salong

Index Scriptorium Estoniae

Salong, Heli, 1958-

2003-01-01

Analüüsitakse Kuressaares aasta jooksul valminud ehitusi, sisekujundust ja reklaamisilte. Parimateks tunnistas žürii koosseisus Lilian Hansar, Urmas Sepp, Endla Tuutma, Vello Liiv, Ainar Viires, Tuuli Org, Terje Truumaa, Sulev Vahtre, Urmas Arike ja Rita Tamm ärihoone Ferrumi (Arhitektuuribüroo Alver Trummal Arhitektid), Kohvik-Veski laienduse (projekt Tuuli Org), eramu Tulika 5 (projekt Kiira Soosaar), pansionaadi Uus-Roomassaare 5 ruumikujunduse (kujundaja Vello Liiv) ja raamatukogu infokeskuse reklaamisildi (kujundaja AB Studio 3)

La persona feliz : personalidad, bienestar psicológico subjetivo y variables predictoras

OpenAIRE

Martín Martín, Carla

2015-01-01

El propósito de este trabajo es realizar una réplica del estudio de Maite Garaigordobil, Jone Aliri e Iraide Fontaneda, titulado “Bienestar Psicológico Subjetivo: diferencias de sexo, relaciones con dimensiones de personalidad y variables predictoras”(2009). En dicho trabajo, analizan diferentes variables en relación al bienestar psicológico subjetivo, exploran las relaciones del bienestar psicológico y el material con las dime...

Mustamäe Maarja Magdaleena kiriku arhitektuurivõistlus = Architecture competition for Mustamäe`s Church of Mary Magdalene / Pille Epner

Index Scriptorium Estoniae

Epner, Pille

2013-01-01

Arhitektuurikonkursist, võidutööst "Fiat Lux" (arhitektid Risto Parve, Kai Süda, Martin Kinks, Margit Valma, arhitektuuriteadlane Mait Väljas, Karisma Arhitektid), 2. koha pälvinud tööst "Õhuke Koht" (Pille Noole, Üllar Ambos, Kaisa Lasner, Kerttu Karjust, Jiannis Lykouras, Arhitektuurinurk), 3. koha pälvinud tööst "Tee" (Villem Tomiste, Stuudio Tallinn). Loetletud ostupreemia ja kolm tunnustuse pälvinud võistlustööd

Barbarid, plastiliinijänes, Miriam ja Frank Muller / Annika Koppel

Index Scriptorium Estoniae

Koppel, Annika

2003-01-01

Nukufilm näitab 4 uut filmi : "Barbarid" (stsenaristid Andrus Kivirähk ja Hardi Volmer, režissöör H. Volmer), "Porgand" (stsenarist Peep Pedmanson, režissöör Pärtel Tall), "Miriami jõulupäkapikk" (stsenaristid Leelo Tungal ja Peep Pedmanson, režissöör Mait Laas), "Kuuvaatleja" (reklaamitreiler Frank Mulleri kellafirmale ; stsenarist, režissöör, kunstnik Mati Kütt)

Zur Interaktion von Genotyp und Ernährung bei Darmkrebs

OpenAIRE

Behrends, Thomas

2013-01-01

Ziel dieser Arbeit war es, sowohl die Auswirkungen einer veränderten Selenversorgung über die Nahrung als auch die Rolle des zentralen Transport- und Speicherproteins für Selen (Selenoprotein P, SepP) auf die intestinale Tumorigenese tierexperimentell zu untersuchen. Eine gestörte SepP-Expression, führte zur Ausbildung größerer Tumore. Durch eine Steigerung der Selenversorgung über die Nahrung eine signifikante Reduktion von Tumoranzahl und Gesamttumorfläche erzielt werden. Hierzu wurde den ...

President Ilves sarjas hoogtöö korras seaduste tegemist / Tuuli Koch

Index Scriptorium Estoniae

Koch, Tuuli

2010-01-01

President Toomas Hendrik Ilvese kõnest iseseisvuspäeval. Arvamust avaldavad justiitsminister Rein Lang, Riigikogu põhiseaduskomisjoni esimees Väino Linde ja komisjoni aseesimees Evelyn Sepp, sotsiaalminister Hanno Pevkur ning haridus- ja teadusminister Tõnis Lukas. Presidendi vastuvõtu kujundust ja kontserti hindavad lilleseadja Taivo Piller, muusikakriitik Margus Haav ja Rakvere teatri peanäitejuht Üllar Saaremäe. Küsimustele vastab presidendi vastuvõtu teleülekande produtsent Margus Saar. Juuresoleval fotol justiitsminister Rein Lang presidendi kätlemistseremoonial

Modernistlik ruumikontseptsioon ja nõukogude ideoloogia kohtuvad Viru hotellis / Karen Jagodin

Index Scriptorium Estoniae

Jagodin, Karen, 1982-

2006-01-01

Ajavahemikul 1964-1968 arhitektide Henno Sepmanni ja Mart Pordi poolt projekteeritud ning 1972. a. valminud Viru hotellist Tallinnas, põhjalikum ülevaade hoone interjöörist. Sisearhitektid Väino Tamm, Vello Asi, Taevo Gans, Mait Summatavet ja Loomet Raudsepp. II korruse naiste juuksuri ruumid kujundas Kirsti Laanemaa. II korruse banketisaalis oli Mari Adamsoni gobelään "Tare", suures restoranisaalis Aet Andresma-Tamme ja Mare Soovik-Lobjakase klaaskompositsioon "Pilved", Viru väljakul Edgar Viiese skulptuur "Merepiiga" (1981)

LGBTQ Inclusion in Educator Preparation: Getting Ready for Gender and Sexual Diversity in Secondary School Settings

Science.gov (United States)

Hoelscher, Mary Helen

While many lesbian, gay, bisexual, transgender, and queer (LGBTQ) students are able to resiliently navigate their public school education many others experience harsh school climates and negative health and educational outcomes. Harassment and bullying of LGBTQ students in school environments have been linked to numerous negative psychological and academic outcomes for students diverse in sexual orientation and/or gender identity. Preparing teacher candidates (TCs) to respond effectively to harassment and bullying of students and to create inclusive curriculum has been recommended to improve outcomes for students. Yet the development of these teaching practices has not been pursued broadly in educator preparation programs (EPPs) or specifically in science EPPs (SEPPs). This dissertation broadens the notion of diversity traditionally attended to in EPPs through three studies. The first study is a holistic single-case study of an LGBTQ-inclusive EPP. It focused on the following three research questions: What were the contextual features that surrounded the LGBTQ-inclusive EPP? What were the specific elements of LGBTQ inclusion in the EPP? And, what were the strengths and weaknesses of the LGBTQ-inclusive EPP? This study drew primarily from data collected from interviews with faculty and administrators in a large post-baccalaureate 5th year preparation for licensure program. Document analysis was used to triangulate and expand upon the data collected during the interviews. A framework for analyzing LGBTQ inclusion across the components of an EPP was developed as part of this study. This study has direct implications for the particular EPP, but also clarifies research needs around LGBTQ inclusion in secondary EPPs. While little has research exists about LGBTQ inclusion in EPPs, far less has been attempted and understood in the discipline of secondary life science. The second study thus narrows its focus from the particulars of LGBTQ inclusion in an EPP to the

Põhjamaade põlisvähemuste omakeelsest meediast / Mait Talts

Index Scriptorium Estoniae

Talts Mait, 1964-

2009-01-01

Artikkel jätkab Läänemere-äärsete etniliste vähemuskultuuride käsitlust. Vt. ka Haridus 5/6 2008, "Põlisvähemuskultuuride meediamaastikult" (latgalite, liivlaste, karaiimide, väikeleedulaste, kašuubide jt. omakeelse meedia hetkeolukorrast ja arenguperspektiividest)

Wallenbergide Investor jätkab kasvustrateegiat / Olev Mait Makk

Index Scriptorium Estoniae

Makk, Olev Mait

2001-01-01

Wallenbergide kontrollitavast Rootsi investeerimisfirmast Investor, mille omanduses olevad firmad moodustavad kokku Euroopa suurima tööandja erasektoris. Investori gruppi kuuluvast ettevõttest SEB. Tabel: Investori portfellis olevad aktsiad; investori teenused tütarettevõtetele

The singing revolution : part II-III / Mait Ando Raun

Index Scriptorium Estoniae

Raun, Mait, 1963-

2000-01-01

Tartu rahu ja vabariigi aastapäeva tähistamisest 1988. aastal; Sündmused veebruarist aprillini 1988: üliõpilaste demonstratsioonist veebruaris, Loominguliste Liitude ühispleenumist, Rahvarinde loomisest ja Tartu muinsuskaitsepäevadest aprillis. Järg nr.4, lk.70-73

Ma olen Turist, ma elan siin / Mait Väljas

Index Scriptorium Estoniae

Väljas, Mait

2006-01-01

Endise valuutapoe, praeguse klubi "Parlament" lammutamisplaanist Tallinnas Tartu mnt. 17. Arhitektid Peep Jänes ja Henno Sepmann, sisearhitekt Toivo Gans, sisekujundaja Aulo Padar. Ehitamisel osalesid ka soome arhitektid Kalle-Heiki Narinen ja Tapio Hänninen. Kommentaar Peep Jäneselt ja Aulo Padarilt

10 aastat kostüümidraamat / Kaire Raave, Katrin Pauts, Kaja Roomets

Index Scriptorium Estoniae

Raave, Kaire

2007-01-01

Oma rõivastusest vabariigi aastapäeva presidendi vastuvõttudel räägivad Eesti Kunstiakadeemia rektor Signe Kivi, dirigent Eri Klasi abikaasa Ariel, Riigikogu liige Evelyn Sepp, tippärimehe Urmas Sõõrumaa kaasa Kätlin Maran ja Võru linnapea Ivi Eenmaa. Lisatud valik fotosid presidendi vastuvõttudest aastatel 1999-2006. Vt. samas: President Toomas Hendrik Ilves 9 aastat presidendi vastuvõtul. Pikemalt Signe Kivi kleitidest ja näitusest "24. veebruar" Disaini- ja Arhitektuurigaleriis, kus on eksponeeritud tema kõiki vastuvõttudel kantud kleite

Reporting of lipidomics data should be standardized

DEFF Research Database (Denmark)

Liebisch, Gerhard; Ekroos, Kim; Hermansson, Martin

2017-01-01

This article highlights, to our opinion, some of the most pertinent issues related to producing high quality lipidomics data. These issues include pitfalls related to sample collection and storage, lipid extraction, the use of shotgun and LC-MS-based lipidomics approaches, and the identification......, annotation and quantification of lipid species. We hope that highlighting these issues will help stimulate efforts to implement reporting standards for dissemination of lipidomics data. This article is part of a Special Issue entitled: BBALIP_Lipidomics Opinion Articles edited by Sepp Kohlwein....

Kas Eestil on lootust? / Jüri Sepp, Erik Terk

Index Scriptorium Estoniae

Sepp, Jüri, 1952-

2007-01-01

Autorid vaatlevad mitmete edetabelite põhjal, kuidas Eestil on läinud teiste riikidega võrreldes, ning nimetavad probleeme Eesti edasiliikumisel. Nende hinnangul ei seisne Eesti ühiskonna tulevikuprobleem mitte selles, kas ohverdada sotsiaalsust liberaalsusele või vastupidi, vaid selles, kuidas neid kahte asja ühendada. Artikli alus on "Eesti inimarengu aruanne 2006"

Kas Eestil on lootust? / Jüri Sepp, Erik Terk

Index Scriptorium Estoniae

Sepp, Jüri, 1952-

2012-01-01

Autorid vaatlevad mitmete edetabelite põhjal, kuidas Eestil on läinud teiste riikidega võrreldes, ning nimetavad probleeme Eesti edasiliikumisel. Nende hinnangul ei seisne Eesti ühiskonna tulevikuprobleem mitte selles, kas ohverdada sotsiaalsust liberaalsusele või vastupidi, vaid selles, kuidas neid kahte asja ühendada. Artikli alus on "Eesti inimarengu aruanne 2006"

salmepaat.blogspot.com vahendab muistsete saladuste paljastamist / Andres Sepp

Index Scriptorium Estoniae

Sepp, Andres

2008-01-01

Saaremaalt Salmelt leitud muinaspaadi uurimistööde tulemuste avalikustamiseks lõid arheoloogid Eestis spetsiaalse blogi. Konservaator Aive Rumm Tallinna Ülikooli Ajaloo Instituudist teeb blogis kokkuvõtte Salme muinaslaevast pärit metallesemete seisukorrast ning nende konserveerimise viisidest

Tuul võib hakata Saaremaale elektrit andma / Andres Sepp

Index Scriptorium Estoniae

Sepp, Andres, 1976-

2001-01-01

Taani kapitalil põhinev OÜ Roomapark asub uurima, kas investeerida sadu miljoneid kroone Kuressaare lähistele Roomassaare poolsaarele tuulegeneraatorite püstitamiseks. Taani kontsern World Wide Wind (WWW)

Kuidas tõlkida loojaid riigiametnikele ja vastupidi? / Andreas Sepp

Index Scriptorium Estoniae

Sepp, Andreas

2010-01-01

Oktoobris 2010 toimus Tallinna Ülikooli Balti Filmi- ja Meediakooli korraldatud loengusari "Creative and Cultural Industries Policy in Europe", kus keskenduti Euroopa Liidu loomemajanduse regulatiivpoliitikale. Kursuse viisid läbi õppejõud Bernd Hartmann ja Jan Runge Saksamaalt

Lauluväljaku uus skulptuur visualiseerib heli / Andreas Sepp

Index Scriptorium Estoniae

Sepp, Andreas

2011-01-01

14. mail Tallinna lauluväljakul Euroopa kultuuripealinna segakoori kontserdiga avatavast saksa skulptori Lukas Kühne loodud akustilisest skulptuurist "Chromatico". Teose arhitekt on Rosario Nuin (Uruguay), ehitas Nordecon Betoon

Kas Tallinn vajab uut brändi? / Andreas Sepp

Index Scriptorium Estoniae

Sepp, Andreas

2010-01-01

Tallinnas viibinud saksa loomemajanduse õppejõudude Bernd Hartmanni ja Jan Runge sõnul on kultuuripealinna aasta hea võimalus linnakuvandi parandamiseks. Nende arvates võiks Tallinn kultuuripealinna raames anda noortele disaineritele ja filmitegijatele loomingu eksponeerimiseks piisavalt võimalusi ning keskenduda kohaliku kultuurielu parandamisele

Planning and Designing Effective Defence and Related Information Services: Conference Proceedings of the Technical Information Panel Specialists’ Meeting Held in Ankara, Turkey on 10-11 September 1986.

Science.gov (United States)

1987-04-01

Is Defense, en alant au-doll de ce qua peut apporter un simple repertoire, commae celul du DTIC aux Etats-Unis (5). ii counvient donc de dhvelopper...en consultation mais devront etre exclus du prit. Maits touts laide qua h’on apportersa Al’utilisaeur, celul -ci perdra besucoup do tampa I cee...mains quoun systme do guichat ivolui. come celul dont il a iti question plus haut, soit jug& prifirable. 8-5 2.3. Sources primaires. Touts information

Olika förklaringar till lägre straffnivåer i de nordiska länderna jämfört med övriga europeiska

DEFF Research Database (Denmark)

Bondeson, Ulla V.

2007-01-01

). Both of us emphasize economic variables such as GDP and welfare expenditures, as well social inequality. I juxtapose political factors, referred to by Lappi-Seppälä as "consensual democracies" and "neo-corporativism", with the theory of " functional democracy". In regard to increasing rates......, though I stress that different formulations of the question produce different results. I argue against the common postulate of penal populism starting in the 1980s and point to the constancy of penal and other social attitudes over the decades, as demonstrated in my book, Nordic Moral Climates (2003...

24th Annual Canadian Conference on HIV/AIDS Research/24e Congr?s Annuel Canadien de Recherche sur le VIH/sida CAHR Committees / Comit?s de l?ACRV

OpenAIRE

Hogg, Robert; Hogg, Robert; Hart, Trevor; Tan, Darrell; Hart, Trevor; Tan, Darrell; Boily-Larouche, Genevi?ve; Lajoie, Julie; Omollo, Kenneth O; Cheruiyot, Julianna; Njoki, Jane; Kimani, Makubo; Oyugi, Julius; Kimani, Joshua; Fowke, Keith R

2015-01-01

BACKGROUND: The C-type lectin CD161 is expressed by CD4+ and CD8+ T cells sharing conserved transcriptional and functional signature. CD4+ T cells with type-17 profiles derived from CD161+ precursors and CD161-expressing CD8+ T cells share the same differentiation profile and include the unique anti-bacterial CD161++ mucosal-associated invariant T cells (MAIT) expressing invariant TCR V?7.2. During HIV infection, circulating cells harbouring the signature of CD161+ cells are impaired in blood...

Eesti teatri aastaauhinnad 2001

Index Scriptorium Estoniae

2002-01-01

Lavastajaauhind Hendrik Toompere, meesnäitleja Mait Malmsten, naisnäitleja Kersti Kreismann, meeskõrvalosatäitja Sulev Teppart, naiskõrvalosatäitja Kersti Tombak, kunstnikupreemia Ene-Liis Semper, eriauhind Marko Matvere, tantsulavastuse auhind Age Oks, Toomas Edur, Katrin Essenson, kriitikuauhind Reet Neimar ja Lea Tormis, Ants Lauteri preemia Katariina Lauk-Tamm ja Andres Raag, Salme Reegi auhind VAT Teater, Priit Põldroosi preemia Ingo Normet, Aleksander Kurtna preemia Tõnu Oja ja Villu Kangur, Georg Otsa preemia Pille Lill, muusikalavastuse auhind Mati Palm, muusikalavastuse eriauhind Teo Maiste

Finskii grafitsheskii beton teper takzhe i v Estonii / Mait Eelrand

Index Scriptorium Estoniae

Eelrand, Mait

2007-01-01

Graafilise betooni meetodi arendas 1990. aastate lõpul välja soome sisearhitekt Samuli Naamanka, tehnoloogia on patenteerinud tema asutatud firma Graphic Concrete Oy. AS E-Betoonelement kasutas graafilise betooni tehnoloogiat esimesena Rakveres büroohoone fassaadi kujundamiseks. Kommenteerivad Graphic Concrete Oy tegevdirektor H. Lanningu ja K. Meus AS-st E-Betoonelement

Oluline teatmeteos, mis võinuks olla veelgi parem / Mait Talts

Index Scriptorium Estoniae

Talts, Mait, 1964-

2010-01-01

Arvustus: Eesti perioodika 1941-1944 = Estnische Periodika 1941-1944 = Periodicals in Estonia 1941-1944 = Эстонская периодика 1941-1944 / Eesti Rahvusraamatukogu ; koostanud Külli Kaunissaar. Tallinn, 2009. (Eesti retrospektiivne rahvusbibliograafia)

Enno Toomsalu 30 aastat Chicago Eesti Maja president / Endel Sepp

Index Scriptorium Estoniae

Sepp, Endel

2006-01-01

1976. aastast Eesti Maja juhtinud Enno on kujundanud selle "väikeseks Eestiks", kus on korraldatud palju kultuuriüritusi. 19. märtsi koosolekul andis ta ameti nooremale, samas valiti ta Chicago Eesti Maja auliikmeks. Akadeemiliselt kuulub ta Korp! Frat. Estica´sse, teda on autasustatud korporatsiooni Kuldmärgiga teenete eest eestlusele ja Valgetähe 4. järgu ordeniga

Ruhnu saarele hakkab lennutama Saksa firma / Mehis Tulk, Andres Sepp

Index Scriptorium Estoniae

Tulk, Mehis, 1967-

2006-01-01

Ilmunud ka: Meie Maa 9. nov lk. 1. Riigihankekonkursi Pärnu-Ruhnu-Kuressaare lennuliini teenindamiseks võitnud Saksa firmaga Luftverkehr Friesland Brunzema und Partner KG sõlmib Saare maavalitsus avaliku teenindamise lepingu neljaks aastaks. Kaart

Ralf Tamm - unistaja tehismaastikul / Ralf Tamm ; interv. Aino Ingrid Sepp

Index Scriptorium Estoniae

Tamm, Ralf

2008-01-01

Eramuile spetsialiseerunud arhitekt Ralf Tamm sellest, miks ta eelistab projekteerida eramuid, eramust visiooni kujunemisest, betoonist, hea arhitektuuri loomise eeldustest, eesti arhitektuuri lähitulevikust, tuleviku töövahenditest, enda tööstiilist jm. Abikaasa disainer Angela Orgusaar Ralf Tammest. Eramu "Vana laev" tellija Tarmo Ojakääru kommentaar. 13 ill

Omanikud lõpetavad skandaalse firma Kuressaare Golf tegevuse / Andres Sepp

Index Scriptorium Estoniae

Sepp, Andres, 1976-

2004-01-01

AS Kuressaare Golf likvideeritakse, sest Põduste jõe äärde kavandatud golfiväljaku ehitamise plaanid sumbusid, kuna firma aktsionäride vahel tekitas tüli rahakantimise kahtlus. Kommenteerib AS-i Kuressaare Golf juhatuse liige Meelis Põlda

Uued raamatud

Index Scriptorium Estoniae

2008-01-01

Fotoalbum "Väikeste majade Haapsalu" (Evald Okase Muuseum, 2008; toimetajad Üla Koppel ja Ingrid Ruudi, kujundaja Pärtel Eelma, fotod: Ly Lestberg, Katrin Rihm, Lembit Michelson, Liivia Leshkin, Piret Looveer, Erki Meister, Romer Laidsaar, Karli Luik, Maris Kerge, Üla Koppel). "Tallinna maja : hoonetüübi areng ja säästev uuendamine" (Tallinna Kultuuriväärtuste Amet, 2008; ajaloolise osa koostas Mark Sepp). Näituse kataloog "Keskkonnad, projektid, kontseptsioonid. Tallinna kooli arhitektid 1972-1985" (Eesti Arhitektuurimuuseum, 2008; koostajad Andres Kurg ja Mari Laanemets, kujundaja Indrek Sirkel, tekstid: A. Kurg, M. Laanemets, Juhani Pallasmaa, Georg Schöllhammer)

Lipidomics in research on yeast membrane lipid homeostasis.

Science.gov (United States)

de Kroon, Anton I P M

2017-08-01

Mass spectrometry is increasingly used in research on membrane lipid homeostasis, both in analyses of the steady state lipidome at the level of molecular lipid species, and in pulse-chase approaches employing stable isotope-labeled lipid precursors addressing the dynamics of lipid metabolism. Here my experience with, and view on mass spectrometry-based lipid analysis is presented, with emphasis on aspects of quantification of membrane lipid composition of the yeast Saccharomyces cerevisiae. This article is part of a Special Issue entitled: BBALIP_Lipidomics Opinion Articles edited by Sepp Kohlwein. Copyright © 2017 Elsevier B.V. All rights reserved.

Milliseid erialaseid teadmisi ja oskusi olete kasutanud oma praeguses ametis? : vastavad infoteaduse eriala vilistlased / interv. Hela Ojasaar, Margot Mahlapuu

Index Scriptorium Estoniae

2005-01-01

Vastavad: EV Presidendi Kantselei direktori asetäitja, üldosakonna juhataja Riina Roomet, Mahtra Talurahvamuuseumi direktor Tiia-Helle Schmitte, EBS-i raamatukogu juhataja Eda Pihu, Euroopa Liidu asjade komisjoni nõunik (Riigikogu) Külli Kask, Kultuuriministeeriumi raamatukogunõunik Meeli Veskus, Võrumaa Keskraamatukogu direktor Inga Kuljus, Lääne Maakonna Keskraamatukogu direktor Ilme Sepp, Riigiarhiivi direktor Marge Tiidus, kirjastuse Pilgrim juht Tiina Ristimets, Tallinna Keskraamatukogu direktor Kaie Holm, Eesti ENIC/NARIC Keskuse infospetsialist Liia Tüür, Eesti Rahvusraamatukogu direktor Tiiu Valm, Tartu Ülikooli Raamatukogu teenindusdirektor Mare-Nelli Ilus, Viljandi Kultuuriakadeemia raamatukogunduse ja infoteaduste osakonna juhataja Ilmar Vaaro

Presidendi taluehitaja mängib võlausaldajatega peitust / Ingvar Bärenklau

Index Scriptorium Estoniae

Bärenklau, Ingvar, 1967-

2007-01-01

President Toomas Hendrik Ilvese ja proua Evelin Ilvese Ärma talus ehitustöid korraldanud ning alltöövõtjatele võlgu jäänud Aus Invest OÜ omanikud Aivar ja Mait Aus on läinud võlausaldajate eest peitu Norrasse ning kirjutanud oma vara teiste isikute nimele. Vt. samas: Presidenditalu rahavaidlus. Aus Invest on jätnud tasumata maaparandus- ja pinnasetöödefirmale AS Nuia Melior ja Pärnu puidutööstusele AS Puit. Proua Evelin Ilvese kinnitusel on Ärma talu omanikfirma Ermamaa Aus Investile kui peatöövõtjale kõik arved tasunud

Delineating hierarchy of selenotranscriptome expression and their response to selenium status in chicken central nervous system.

Science.gov (United States)

Jiang, Xiu-Qing; Cao, Chang-Yu; Li, Zhao-Yang; Li, Wei; Zhang, Cong; Lin, Jia; Li, Xue-Nan; Li, Jing-Long

2017-04-01

Selenium (Se) incorporated in selenoproteins as selenocysteine and supports various important cellular and organismal functions. We recently reported that chicken brain exhibited high priority for Se supply and retention under conditions of dietary Se deficiency and supernutrition Li et al. (2012) . However, the selenotranscriptome expressions and their response to Se status in chicken central nervous system (CNS) are unclear. To better understand the relationship of Se homeostasis and selenoproteins expression in chicken CNS, 1day-old HyLine White chickens were fed a low Se diet (Se-L, 0.028mg/g) supplemented with 4 levels of dietary Se (0 to 5.0mgSe/kg) as Na 2 SeO 3 for 8weeks. Then chickens were dissected for getting the CNS, which included cerebral cortex, cerebellum, thalamus, bulbus cinereus and marrow. The expressions of selenoproteome which have 24 selenoproteins were detected by the quantitative real-time PCR array. The concept of a selenoprotein hierarchy was developed and the hierarchy of different regions in chicken CNS was existence, especially cerebral cortex and bulbus cinereus. The expression of selenoproteins has a hierarch while changing Se content, and Selenoprotein T (Selt), Selenoprotein K (Selk), Selenoprotein W (Selw), Selenoprotein U (Selu), Glutathione peroxidase 3 (Gpx3), Glutathione peroxidase 4 (Gpx4), Selenoprotein P (Sepp1), Selenoprotein O (Selo), Selenoprotein 15 (Sel15), Selenoprotein N (Seln), Glutathione peroxidase 2 (Gpx2) and Selenoprotein P 2 (Sepp2) take more necessary function in the chicken CNS. Therefore, we hypothesize that hierarchy of regulated the transcriptions of selenoproteome makes an important role of CNS Se metabolism and transport in birds. Copyright © 2017 Elsevier Inc. All rights reserved.

Soomlaste graafiline betoon nüüd ka Eestis / Mait Eelrand

Index Scriptorium Estoniae

Eelrand, Mait

2007-01-01

Graafilise betooni meetodi arendas 1990. aastate lõpul välja soome sisearhitekt Samuli Naamanka, tehnoloogia on patenteerinud tema asutatud firma Graphic Concrete Oy. AS E-Betoonelement kasutas graafilise betooni tehnoloogiat esimesena Rakveres büroohoone fassaadi kujundamiseks. Kommenteerivad Graphic Concrete Oy tegevdirektor H. Lanningu ja K. Meus AS-st E-Betoonelement

Mait Müntel lahendab teaduse suurt ristsõna / intervjueerinud Kristi Helme

Index Scriptorium Estoniae

Müntel, Mait

2010-01-01

Intervjuu keemilise ja bioloogilise füüsika instituudi noore teadlasega, kes pälvis Vabariigi Presidendi Kultuurirahastu noore teadlase preemia. Ta on kaitsnud doktoritöö teemal „Topeltlaetud Higgsi bosoni detekteerimine CMS-i detektoril”

Ettevõtte konkurentsieelis inimeste analüüsi abil / Mait Raava

Index Scriptorium Estoniae

Raava, Mait

2015-01-01

Ettevõtte töötajate analüüsimisest, analüütika tulemuste rakendamisest juhtivates ettevõttes. Viiest sambast, millel põhineb inimeste analüüsi edukas rakendamine, analüütika rakendamise etapid

Tagasisidet peab töötajale vahendama ülemus / Mait Raava

Index Scriptorium Estoniae

Raava, Mait

2004-01-01

Autor teeb lühiülevaate 360ʻ ja teiste tagasiside meetodite rakendamisest maailmas alates 1950ndatest aastatest ning juhib tähelepanu vigadele, mida meetodi rakendamisel on tehtud. Kommenteerib Irene Metsis. Skeem: Juht saab tagasiside nelja kanali kaudu. Vt. samas: Rollist tulenevalt on tagasiside erinev

Kulu- ja turupõhisest hinnakujundamise strateegiast turunduses / Mait Miljan, Kalev Kaarna

Index Scriptorium Estoniae

Miljan, Mait

2005-01-01

Tänapäevases ärikeskkonnas soovitavad autorid kasutada kombineeritud mudelit, milles rakendatakse kulu- ja turupõhist strateegiat lähtuvalt ettevõtte turusituatsioonist, tegevusvaldkonnast ning püütakse liikuda ühtse hinnakujundamiseni tarneahelas kui tervikus. Skeemid

Raginal rannavormi / kommenteerinud Reet Puks, Merily Lehis, Helle Nurmsalu, Galina Sepp

Index Scriptorium Estoniae

2010-01-01

Ilusalongides pakutavatest salendavatest kehahooldusprotseduuridest aparaatidega - LPG edermoloogiline massaaž, Universal Contour Wrap, ULTRATONE intensiivne tselluliidiravi ja mittekirurgiline facelift, Shockmaster AWT meetod (akustilise laine ravi)

Revisiting the configuration of small satellites structures in the framework of 3D Additive Manufacturing

Science.gov (United States)

Gaudenzi, P.; Atek, S.; Cardini, V.; Eugeni, M.; Graterol Nisi, G.; Lampani, L.; Pasquali, M.; Pollice, L.

2018-05-01

In this paper the AM-induced evolution of the design process for small satellites is investigated, leading to the identification of optimal design strategies and the definition of a new MAIT concept. A review of the open literature is presented and some introductory concepts are exposed to highlight the effect of the introduction of AM technologies in the development of new satellites systems. In particular, an innovative structural configuration for the CubeSat class of satellites is proposed, with the ultimate goal of minimizing system complexity via parts reduction and the integration of subsystems through an innovative assembly configuration, as an example to be considered for larger satellites.

Selenium deficiency occurs in some patients with moderate-to-severe cirrhosis and can be corrected by administration of selenate but not selenomethionine: a randomized controlled trial123

Science.gov (United States)

Burk, Raymond F; Hill, Kristina E; Motley, Amy K; Byrne, Daniel W; Norsworthy, Brooke K

2015-01-01

Background: Selenomethionine, which is the principal dietary form of selenium, is metabolized by the liver to selenide, which is the form of the element required for the synthesis of selenoproteins. The liver synthesizes selenium-rich selenoprotein P (SEPP1) and secretes it into the plasma to supply extrahepatic tissues with selenium. Objectives: We conducted a randomized controlled trial to determine whether cirrhosis is associated with functional selenium deficiency (the lack of selenium for the process of selenoprotein synthesis even though selenium intake is not limited) and, if it is, whether the deficiency is associated with impairment of selenomethionine metabolism. Design: Patients with Child-Pugh (C-P) classes A, B, and C (mild, moderate, and severe, respectively) cirrhosis were supplemented with a placebo or supranutritional amounts of selenium as selenate (200 or 400 μg/d) or as selenomethionine (200 μg/d) for 4 wk. Plasma SEPP1 concentration and glutathione peroxidase (GPX) activity, the latter due largely to the selenoprotein GPX3 secreted by the kidneys, were measured before and after supplementation. Results: GPX activity was increased more by both doses of selenate than by the placebo in C-P class B patients. The activity was not increased more by selenomethionine supplementation than by the placebo in C-P class B patients. Plasma selenium was increased more by 400 μg Se as selenate than by the placebo in C-P class C patients. Within the groups who responded to selenate, there was a considerable variation in responses. Conclusion: These results indicate that severe cirrhosis causes mild functional selenium deficiency in some patients that is associated with impaired metabolism of selenomethionine. This trial was registered at clinicaltrials.gov as NCT00271245. PMID:26468123

NOMAD on the ExoMars TGO 2016 mission: MAIT and characterisation testing

Science.gov (United States)

Vandaele, Ann C.; Neefs, Eddy; Lopez-Moreno, J. J.; Rodriguez Gomez, Julio; Drummond, Rachel; Patel, Manish; Thomas, Ian; Gissot, Samuel; Depiesse, Cedric; Ben Moussa, Ali; Giordanengo, Boris; Bellucci, Giancarlo

NOMAD, the “Nadir and Occultation for MArs Discovery” spectrometer suite has been selected by ESA and NASA to be part of the payload of the ExoMars Trace Gas Orbiter mission 2016. This instrument suite will conduct a spectroscopic survey of Mars’ atmosphere in the UV, visible and IR regions covering the 0.2-0.65 and 2.2-4.3 μm spectral ranges. NOMAD’s observation modes include solar occultation, nadir and limb observations. The NOMAD instrument is composed of 3 channels: a solar occultation only channel (SO) operating in the infrared wavelength domain, a second infrared channel capable of observing nadir, solar occultation and limb observations (LNO), and an ultraviolet/visible channel (UVIS) that can work in all observation modes. The spectral resolution of SO and LNO surpasses previous surveys in the infrared by more than one order of magnitude. NOMAD offers an integrated instrument combination of a flight-proven concept (SO is a copy of SOIR on Venus Express), and innovations based on existing and proven instrumentation (LNO is based on SOIR/VEX and UVIS has heritage from the ExoMars lander), that will provide mapping and vertical profile information at high spatio-temporal resolution. The three channels have each their own ILS and optical bench, but share the same single interface to the S/C. The NOMAD flight model is due for delivery to ESA in January 2015. We will present results so far of the manufacturing, assembly and especially testing of the various components. The UV CCDs have been characterised in thermal-vacuum; optical fibres have been studied with UV exposure to look at transmission degradation; the IR AOTFs have been tested for their transfer functions; lifetime and vibration testing has been carried out on the flip mirror mechanism. These are all vital inputs to the scientific results from NOMAD. Acknowledgements - The research program was supported by the Belgian Federal Science Policy Office and the European Space Agency (ESA PRODEX program). IAA participation is funded by MICIIN through Plan Nacional Ref. AYA2009-08190. UVIS support provided by the Open University and partly by STFC. Italian participants acknowledge the support from ASI.

Kunstide sünesteesia. Tasapinnalise visuaali ja muusika suhted / Einike Leppik

Index Scriptorium Estoniae

Leppik, Einike

2010-01-01

Uuritakse ja analüüsitakse kunstide sünesteesia printsiipe, ajaloolist kujunemist ja seoseid kujutava kunsti ja muusika loomisel. Lähtutud on 20. sajandil alguse saanud ja tänapäevani kestvatest arengutest kunstis - kunsti piiride hägustumisest, laienemisest ning nähtustest, mis nende arengutega kaasas on käinud 1890-1960-ndateni. Tõmmatakse paralleele Kandinsky abstraktsete impressioonide ja Schönbergi atonaalse helikeele, Claude Monet' maalide ja Claude Debussy muusika vahel, Čiurlionise kui kunstniku ja muusiku fuugamaastike, Eric Satie sünesteetilise kunsti ja John Cage'i jt. loomingu vahel. Praktilise tööna on 33 joonistusest kokku pandud installatsioon "Joon", mille põhjal komponeeris muusika EMTA tudeng Mait Jüriado

Détection des symptômes anxieux et dépressifs en médecine générale

OpenAIRE

Bertin Persichini, Caroline

2015-01-01

Contexte : L’anxiété et la dépression sont des problèmes de santé publique. Ces troubles sont fréquents et il est indispensable de les diagnostiquer. Le diagnostic se fait principalement par les médecins généralistes et se base sur leur intuition.Objectif : L’objectif principal était d’établir la sensibilité et la spécificité des médecins généralistes dans la détection de l’anxiété et de la dépression, quelque soit le motif de consultation.Méthodes : Les médecins participants étaient des mait...

Akrobaatikaõpetaja lõi Draculateemalise tsirkuseetenduse / Alissa Šnaider ; intervjueerinud Andreas Sepp

Index Scriptorium Estoniae

Šnaider, Alissa, 1985-

2011-01-01

Kadriorus 5.-13. augustini kestva rahvusvahelise uue tsirkuse festivali "Tsirkusepuu" raames esietendub 12. augustil stuudio OMAtsirkuse "Dr. Acula". Intervjuu tsirkuseetenduse lavastanud akrobaatikaõpetaja ja koreograafi Alissa Šnaideriga

Uusi võimalusi pakkuv kasulik bakter / Villu Päärt, Siim Sepp

Index Scriptorium Estoniae

Päärt, Villu, 1972-

2008-01-01

Äsja võitis Lactobacillus fermentum ME-3 avastaja Tartu Ülikooli professor Marika Mikelsaar koos kolleegidega Soulis ülemaailmsel naisleiutajate konkursil kuldmedali. Bakterite omaduste uurimine jätkub. Marika Mikelsaare juhtimisel katsetati kõhutüüfusesse nakatatud hiirte peal, millist mõju avaldab see, kui antibiootikumi ravi ajal anda hiirtele ka ME-3 sisaldavat probiootikumi

"Soft" factors of economic development : human capital and institutsions / Jüri Sepp

Index Scriptorium Estoniae

Sepp, Jüri

2006-01-01

Töös on analüüsitud võimalusi empiiriliselt eristada riikide tegelikult saavutatud ja potentsiaalset majandusarengu taset. Tugineti mõlemale majandusarengu tugiteooriale - tootmisfunktsioonist lähtuvale kasvuteooriale ja institutsionaalsele arengukontseptsioonile. Eesti konvergentsivõimalusest arenenud riikidega

Roberto Dapit, La Slavia friulana - Beneška Slovenija. Lingue e culture: Resia, Torre, Natisone - Jezik in kultura: Rezija, Ter, Nadiža. Bibliografia ragionata - Kritična biblio­grafija, Circolo Zadroga "Lipa", San Pietro al Natisone - Špeter 1995, 138 p.

Directory of Open Access Journals (Sweden)

Mitja Skubic

1995-12-01

Full Text Available E' possibile che al linguista non slavista il titolo non dica gran che. Eppure, per merito anche del linguista polacco Ian Baudouin de Courtenay, il dialetto sloveno di Resia, del Torre e del Natisone, queste parlate slovene sono fra le più studiate, anche dai linguisti stranieri: De Courtenay, poi, più recentemente Gian Battista Pellegrini, Giu­ seppe Francescato, Giovanni Frau, Antonio Maria Raffo da parte italiana e friulana; per la parte slovena possiamo ricordare Karel Strekelj, Fran Ramovs, Tine Logar, Pavle Merkù, Neva Godini, Liliana Spinozzi-Monai, Rado Lencek. E' doveroso, poi, citare l'americano Eric Hamp e l'olandese Han Steenwijk. Un posto a parte spetta a Milka Maticetov perché congiunge gli interessi linguistici con quelli etnologici.

Structure- and cell-specific effects of imidoselenocarbamates on selenoprotein expression and activity in liver cells in culture.

Science.gov (United States)

Ibáñez, Elena; Stoedter, Mette; Hofmann, Peter Josef; Plano, Daniel; Calvo, Alfonso; Nguewa, Paul A; Palop, Juan Antonio; Sanmartín, Carmen; Schomburg, Lutz

2012-12-01

The essential micronutrient selenium (Se) exerts its biological effects mainly through selenoproteins thereby affecting a number of physiological pathways including intracellular redox control, stress response and cancer cell proliferation. Besides affecting selenoprotein expression, some selenocompounds have been synthesized and analyzed in order to serve as chemotherapeutic substances preferentially targeting cancer cells. This promising chemotherapeutic potential has recently been verified for a particular imidoselenocarbamate in a mouse tumor model. In the present study we tested the effects of this and a number of related Se-methyl- and Se-benzyl-imidoselenocarbamates on selenoprotein expression in nontransformed and hepatic carcinoma cells in culture. Most of the Se-benzyl-imidoselenocarbamates strongly stimulated selenoprotein P (SePP) secretion while the Se-methyl-imidoselenocarbamates elicited less pronounced effects in hepatocarcinoma HepG2 cells. However, most of the Se-methyl-imidoselenocarbamates increased glutathione peroxidase (GPx) activity and decreased thioredoxin reductase (TXNRD) activity in parallel, while the majority of the Se-benzyl-imidoselenocarbamates were without a respective effect in HepG2 cells. Performing inhibitor assays in vitro, GPx activity was unaffected by the imidoselenocarbamates. In contrast, most of the Se-methyl-imidoselenocarbamates inhibited TXNRD activity in vitro in line with the results in HepG2 cells. Both classes of imidoselenocarbamates strongly induced selenoprotein S (SELS) expression without a respective increase in ER stress or unfolded protein response which are known inducers of SELS biosynthesis. Notably, many of these effects were cancer cell-specific, and not observed in nontransformed AML12 hepatocytes. Our results indicate that these novel selenocompounds affect expression and activity of crucial selenoenzymes in a compound- and cell-specific way in hepatocytes. Especially the Se

Applying theory of constraints in tactical and strategic management / Kalev Kaarna, Mait Miljan

Index Scriptorium Estoniae

Kaarna, Kalev

2002-01-01

Bibliogr. lk. 86-87. - Kokkuvõte eesti keeles lk. 87. Piirangute teooria kasutamise vajadusest ja võimalustest. Piirangute juhtimisest pikas perspektiivis ning sellel põhinevast strateegilisest juhtimisest. Tabelid

Majad ja muutumised marsruudil JPN-USA-EST / Tomomi Hayashi ; intervjueerinud Mait Väljas

Index Scriptorium Estoniae

Hayashi, Tomomi, 1971-

2011-01-01

Intervjuu Jaapanis Toyamas sündinud ning Eestis elava ja töötava arhitekti Tomomi Hayashiga, kes aastast 2004 on HG Arhitektuur OÜ arhitekt ja partner. Endast, tööst New Yorgis Rafael Viñoly büroos, Eestisse tulekust, oma tööpõhimõtetest, lemmikarhitektidest, järgmisest ehitusbuumist jm. Loetletud T. Hayashi töid, preemiad

Turuanalüüs - eduka turunduse juhtimise üks võtmetegur / Mait Miljan

Index Scriptorium Estoniae

Miljan, Mait

2002-01-01

Ettevõtte turunägemuse kujundamisel puutub kokku selliste mõistetega nagu turu definitsioon, turu arenguindeks (Market - MDI), turupotentsiaal, turunõudlus, turuosa arenguindeks (Share Development Index - SDI). Diagrammid

Avaliku võimu ja kodanikualgatuse partnerlus : koostööd mõjutavad tegurid / Krista Hinno, Tanel Vallimäe

Index Scriptorium Estoniae

Hinno, Krista

2007-01-01

Artiklis esitatakse kokkuvõte Tallinna Ülikooli Eesti Humanitaarinstituudi Kodanikeühiskonna Uurimis- ja Arenduskeskuse uurimuse "Avaliku võimu ja kodanikualgatuse komplementaarsed suhted" peamistest tulemustest. Raporti autorite hulka kuulusid Erle Rikmann, Krista Hinno, Aigi Bremse, Kersti Kollom, Mari Sepp ja Tanel Vallimäe. Toetudes uuringutele väidavad autorid, et Eesti ametnikkond on soodsalt meelestatud koostööle kodanikuühendustega, takistuseks võivad saada kodanikeühenduste erinev tööstiil, vajalike ressursside puudus, sh ka ajanappus, ametnike kaadrivoolavus ja teatavate vanusegruppide vähene avatus. Diagrammid: Koostöö jaotumine asutuseliikide vahel; Ametnike hinnang ühistegevuse sisukusele seoses koostöö algatamisega; Ametnike hinnang omaduse vajalikkusele oma töös (vastajate osakaal, kes peavad antud omadust oma töös väga vajalikuks)

Vaata mulle näkku: mu nimi on Oleks Võinud Olla / Andreas Sepp

Index Scriptorium Estoniae

Sepp, Andreas

2011-01-01

Tallinna Fotokuu raames Kumu Kunstimuuseumis rahvusvaheline kaamerakunsti näitus "Teisele poole" 7.10.2011-08.01.2012, kuraator Adam Budak Osaleb 19 kunstnikku, neist tutvustatakse: John Baldessari (California), Sunah Choi (Korea), Haris Epaminonda (Küpros), Helena Almeida (Portugal), Elad Lassry (Iisrael), Alexandre Singh (Prantsusmaa)

Reklaamitööstus teeb naise kehast universaalse märgi / Veljo Sepp

Index Scriptorium Estoniae

Sepp, Veljo

2005-01-01

Piret Räni ühiskonnakriitiline näitus "Hello friend, are you impotent?" Eesti Kunstiakadeemia galeriis. Näha digitrükis kollaazhipannood ning fotouurimus naise keha kasutamisest ruumis ja meedias

Balti kunstnike näitus AABS-i konverentsil : Tulving, Tamasauskas, Ingelevics / Eda Sepp

Index Scriptorium Estoniae

Sepp, Eda

2004-01-01

Tartu College'i saalis Torontos on 3. - 6. juunini 2004 avatud kunstinäitus, kus saab vaadata Rutt Tulvingu serigraafiasarja "What is Man", välisleedulase Otis Tamasauskase suuremõõtmelist graafikat ning välislätlase Ingelevicsi videoinstallatsiooni

Endale lisatasu maksnud Seeder vallandas sama teo eest alluva / Mehis Tulk, Andres Sepp

Index Scriptorium Estoniae

Tulk, Mehis, 1967-

2008-01-01

Taimetoodangu Inspektsiooni peadirektori kohalt vallandatud Mart Mäeker käib kohut põllumajandusministeeriumiga ja on hämmeldunud ministeeriumis valitsevast topeltmoraalist tulemustasude määramisel ja põllumajandusminister Helir-Valdor Seederi käitumisest. Vt. samas: Kaire Uusen. Ministrite suud jäid lukku

Ärma talu ehitanud Aus Invest müüdi Panama riiulifirmale maha / Kadri Paas

Index Scriptorium Estoniae

Paas, Kadri, 1982-

2007-01-01

Ärma talu ehitanud Aus Invest OÜ ei ole maksnud tööde eest kõigile alltöövõtjatele. Proua Evelin Ilvese sõnul on Ermamaa peatöövõtjale kõigi kokkulepitud tööde eest maksnud. 2007. a. mais müüsid Aivar Aus ja Mait Aus Tartu maakohtu registriosakonna andmetel Aus Invest OÜ Panamal registreeritud riiulifirmale Arliana Enterprises Corp. Vt. samas: Nõunik sekkus presidendi teleintervjuusse. Kui telekanali TV3 Lõuna-Eesti reporter Valgamaal visiidil viibivalt Toomas Hendrik Ilveselt ja proua Evelin Ilveselt Ärma talu ehitusega kaasnenud võlgade kohta aru päris, sekkus kõnelusse presidendi avalike suhete nõunik Toomas Sildam. Vt. ka lk. 10: Urmo Soonvald. Ärma triibulised. Ajakirjanik ootab Ärma talu probleemidega seoses suuremat avalikustamist

Meduus Riia rannas / Galina Timtšenko ; intervjueerinud Mihhail Trunin ; tõlkinud Mait Eelrand

Index Scriptorium Estoniae

Timtšenko, Galina

2016-01-01

Intervjuu veebiväljaande Lenta.ru endise peatoimetaja, portaali Meduza looja ja peadirektori Galina Timtšenkoga veebilehest Meduza, ajakirjanduse arengusuundadest ning Baltimaades tegutsevate venekeelsete massiteabevahendite iseärasustest

Regionaalsete toetusprogrammide mõju kohalike omavalitsuste arengule / Monica Hankov, Jüri Sepp, Siret Vildo

Index Scriptorium Estoniae

Hankov, Monica

2004-01-01

Analüüsi tulemustest selgus, et vaatamata toetusprogrammide rakendamisele ei ole regionaalsed erinevused Eesti piirkondade vahel vähenenud. Diagramm. Tabelid. Lisa: EAS regionaalprogrammide sihtalad, nende eripärad ja arengueeldused

Support of small and medium sized enterprises in Estonia / Jüri Sepp, Monica Hankov

Index Scriptorium Estoniae

Sepp, Jüri

2003-01-01

Ettevõtjate seas läbiviidud uuringust selgus, et ettevõtjad hindavad väikeettevõtluse toetuspoliitikat nõrgaks ja ebaefektiivseks; peavad finantseerimise taotlemisel suurimateks probleemideks liiga kõrgeid intressimäärasid, bürokraatiat ja nõrka konkurentsi pangandussektoris; peavad oluliseks koostöö parandamist avaliku ja erasektori vahel.Tabelid. Diagrammid

August Anni(sti) rahvuslik-demokraatlik kultuuriideaal Eesti Vabariigi algusaastail ja vaikival ajastul / Helena Sepp

Index Scriptorium Estoniae

Sepp, Helena, 1964-

2008-01-01

Rahvaluuledoktor August Anni(sti) rahvuslikust kultuurinägemusest ja -visioonist ning suhtumisest natsionalismi, sotsialismi ja demokraatiasse. Allikatena on kasutatud Anni(sti) artikleid, mis ilmusid vaadeldava perioodi kogumikes ja ajakirjanduses

Procedure for obtaining visas for Switzerland and France - Signature rights

CERN Multimedia

2016-01-01

In accordance with the Status Agreements with CERN, Switzerland and France facilitate the entry of members of the Organization’s personnel on to their territories. Where relevant, detailed procedures for obtaining visas apply.   Within the framework of those procedures, only the following individuals are authorised to initiate the Note verbale procedure as well as to sign the Official Invitation Letters and the Conventions d’accueil. Kirsti ASPOLA (EP – CMO) Maite BARROSO LOPEZ (IT – DI) Catherine BRANDT (DG – DI) Michelle CONNOR (TH – GS) Gaëlle DUPERRIER (EP – AGS) Patrick FASSNACHT (EP – ADO) Fernando FERNANDEZ SAVORGNANO (HR – TA) Nathalie GRÜB (EP – AGS) Laurie HEMERY (BE – ASR) Cécile NOELS (ATS – DO) Tania PARDO (EP – AGS) Maria QUINTAS (HR – TA) Kate RICHARDSON (EP –  AGS) Jeanne ROSTANT (TH – GS)...

Tugeva kultuuriga firmas võetakse vastutust, nõrgas süüdistatakse teisi / Mait Raava

Index Scriptorium Estoniae

Raava, Mait

2005-01-01

Ilmunud ka: Delovõje Vedomosti 12. okt. lk. 39; Juhi ideelaegas. - Tallinn, 2006, lk. 10-13. Tugev organisatsioonikultuur suunab töötajaid raskuste korral pingutama, nõrk firmakultuur aga iseenda tagalat kindlustama ja teisi süüdistama

Overview of the M.A.I.T. analysis system (machine analysis of the internal threat)

International Nuclear Information System (INIS)

NiCastro, J.R.

1978-01-01

The problem of the internal threat epitomized by the tactics of collusion and illicit use of access has been structured into a data processing format. The format procedures and analysis are objective; the flexibility of the method allows the security analyst to input his judgment and opinions into the code. By so doing he can interact and determine the effects of interacting with the safeguard system

Carnitine prevents the early mitochondrial damage induced by methylglyoxal bis(guanylhydrazone) in L1210 leukaemia cells.

Science.gov (United States)

Nikula, P; Ruohola, H; Alhonen-Hongisto, L; Jänne, J

1985-06-01

We previously found that the anti-cancer drug methylglyoxal bis(guanylhydrazone) (mitoguazone) depresses carnitine-dependent oxidation of long-chain fatty acids in cultured mouse leukaemia cells [Nikula, Alhonen-Hongisto, Seppänen & Jänne (1984) Biochem. Biophys. Res. Commun. 120, 9-14]. We have now investigated whether carnitine also influences the development of the well-known mitochondrial damage produced by the drug in L1210 leukaemia cells. Palmitate oxidation was distinctly inhibited in tumour cells exposed to 5 microM-methylglyoxal bis(guanylhydrazone) for only 7 h. Electron-microscopic examination of the drug-exposed cells revealed that more than half of the mitochondria were severely damaged. Similar exposure of the leukaemia cells to the drug in the presence of carnitine not only abolished the inhibition of fatty acid oxidation but almost completely prevented the drug-induced mitochondrial damage. The protection provided by carnitine appeared to depend on the intracellular concentration of methylglyoxal bis(guanylhydrazone), since the mitochondria-sparing effect disappeared at higher drug concentrations.

ECOLOGICAL APPROACHES IN THE ORGANIC AGRICULTURAL SYSTEM

Directory of Open Access Journals (Sweden)

Veselka Vlahova

2015-09-01

Full Text Available The permaculture includes landscape shaping, terrace formation, establishment of raised planes and hilly beds. Sepp Holzer’s permaculture has been practices since 1962, having its followers in Columbia, Thailand, Brazil, the USA and Scotland, etc. Important specifics of the Fukuoka method consists of the requirement that the agricultural farm is close to nature, without any attempts to conquer or improve it, whence the method’s name “natural”, i.e. real or natural. In his book entitled “The One-Straw Revolution” the author examines the issues of natural agriculture. The Biodynamic French Intensive method of vegetable gardening combines two gardening traditions: biodynamics, created in the 1920s by Rudolph Steiner, and French intensive gardening, a method practiced by 19th century farmers on the outskirts of Paris. British horticulturist Alan Chadwick bought these methods to the United States in the 1960s and coined the term biointensive. This style of organic gardening focuses on sustainable, high productivity using minimal space.

Alzheimeri tõve vastu võib olla leitud ravim / Villu Päärt, Siim Sepp

Index Scriptorium Estoniae

Päärt, Villu, 1972-

2008-01-01

Austraalia teadlaste juhitud töös uuriti vask- ja tsinkioone siduva ravimi PBT2 mõju AB-ladestusele, mis tekivad transgeensete, nn Alzheimeri hiirte ajus. Hiirtel täheldati juba paari päeva möödudes ajutegevuse paranemist

Kuriteoohvrite abistamisest Eestis : [bakalaureusetöö] / Gerda Sepp ; Tartu Ülikool, õigusteaduskond ; juhendaja: Silvia Kaugia

Index Scriptorium Estoniae

Sepp, Gerda

2009-01-01

Viktimoloogia mõistest ja olemusest, kuritegevusest Eestis viimasel viiel aastal, kuriteo negatiivsest mõjust selle ohvrile, ohvrite reaalsetest võimalustest abisaamiseks praeguses Eestis, hinnangust ohvriabi süsteemile Eestis

Die aktuelle Position Estlands im internationalen Steuerwettbewerb : empirische Ergebnisse / Jüri Sepp, Ralph M Wrobel

Index Scriptorium Estoniae

Sepp, Jüri

2003-01-01

Olulisematest trendidest ja Eesti positsioonist rahvusvahelises maksukonkurentsis nii maksukoormuse, maksude struktuuri kui ka vastavuse mõttes ausa (mittediskrimineeriva) konkurentsi reeglitele. Tabelid

Competition creation and regulation in case of Estonian competition policy / Diana Eerma, Jüri Sepp

Index Scriptorium Estoniae

Eerma, Diana, 1964-

2006-01-01

Riikliku reguleerimise peaeesmärgiks on suurendada majanduslikku ja sotsiaalset heaolu ning luua makro- ja mikromajanduslik keskkond selleks, et kindlustada ettevõtete konkurentsivõime. Eesti konkurentsipoliitika näitel analüüsitakse konkurentsi loomist ja riiklikku reguleerimist turule sisenemisel

Why Innate Lymphoid Cells?

Science.gov (United States)

Kotas, Maya E; Locksley, Richard M

2018-06-19

Innate lymphoid cells (ILCs) are positioned in tissues perinatally, constitutively express receptors responsive to their organ microenvironments, and perform an arsenal of effector functions that overlap those of adaptive CD4 + T cells. Based on knowledge regarding subsets of invariant-like lymphocytes (e.g., natural killer T [NKT] cells, γδ T cells, mucosal-associated invariant T [MAIT] cells, etc.) and fetally derived macrophages, we hypothesize that immune cells established during the perinatal period-including, but not limited to, ILCs-serve intimate roles in tissue that go beyond classical understanding of the immune system in microbial host defense. In this Perspective, we propose mechanisms by which the establishment of ILCs and the tissue lymphoid niche during early development may have consequences much later in life. Although definitive answers require better tools, efforts to achieve deeper understanding of ILC biology across the mammalian lifespan have the potential to lift the veil on the unknown breadth of immune cell functions. Copyright © 2018 Elsevier Inc. All rights reserved.

Anti-NKG2D mAb

DEFF Research Database (Denmark)

Vadstrup, Kasper; Bendtsen, Flemming

2017-01-01

with a wide range of cell types and proteins involved. Natural Killer Group 2D (NKG2D) is an activating receptor constitutively expressed on human Natural Killer (NK), γδ T, mucosal-associated invariant T (MAIT), CD56⁺ T, and CD8⁺ T cells. Activation of NKG2D triggers cellular proliferation, cytokine...... production, and target cell killing. Research into the NKG2D mechanism of action has primarily been focused on cancer and viral infections where cytotoxicity evasion is a concern. In human inflammatory bowel disease (IBD) this system is less characterized, but the ligands have been shown to be highly...... expressed during intestinal inflammation and the following receptor activation may contribute to tissue degeneration. A recent phase II clinical trial showed that an antibody against NKG2D induced clinical remission of CD in some patients, suggesting NKG2D and its ligands to be of importance...

Kangelane ja kaabakas: kuulsad kuningad muistse LähisIda ja Kreeka pärimustes / Mait Kõiv

Index Scriptorium Estoniae

Kõiv, Mait, 1961-

2015-01-01

Mesopotaamia, Pärsia ja Vana-Kreeka kolmest olulisest dünastiast. Akkadi kuningatest - Sargon'ist ja Naram-Sin'ist, Pärsia kuningatest Kyros'est ja Kambyses'est. Korintose türannidest Kypselos'est ja Periandros'est. Pärimuse tagamaadest: müütidest, propagandast ja reaalsusest. Dünastia rajaja kujutamisest kangelasena ja dünastia viimase esindaja demoniseerimisest

Selles töös oli kaks õudust : vangla ja tants / Mait Malmsten ; interv. Tiina Ansip

Index Scriptorium Estoniae

Malmsten, Mait

2005-01-01

Näitleja räägib oma tööst ja rollist rahvusvahelises ühistöös valminud tantsufilmis "Teine" ("Another") : režissöör Rene Vilbre : koreograaf ja peaoaline Helena Jonsdottir. Filmi võtted toimusid Tartu vanglas

Propuesta de programa para una Maestría en Arte e Investigación Teatral (MAIT)

OpenAIRE

Prado Zavala, Jorge

2015-01-01

En México (y Latinoamérica) ha habido pocos intentos para instrumentar posgrados en teatro, y pocos han persistido. En el pasado en México, la UNAM ya intentó construir un programa de maestría en teatro, pero no prosperó. Algunos estudios prefieren concentrarse en la creación, como el proyecto de Maestría en Dirección Escénica de la ENAT, con un antecedente directo en el CUT. Uno de los intentos más recientes es el programa de Maestría en Teatro de la Universidad Veracruzana, la que a partir ...

Identification and field and laboratory tests of the sex pheromone of Cerconota anonella Sepp. (Lepidoptera: Oecophoridae)

Czech Academy of Sciences Publication Activity Database

Pires, E. V.; Mendonca, A. L.; Vaníčková, Lucie; Serra, M. S. J.; da Silva, R. C. C.; dos Santos, D. C.; Campos, R. S.; Santana, A. E. G.; do Nascimento, R. R.

2016-01-01

Roč. 140, 1/2 (2016), s. 72-80 ISSN 0931-2048 Institutional support: RVO:61388963 Keywords : Annona fruit borer * GC x GC-TOFMS * GC-EAD * sex pheromone Subject RIV: EG - Zoology Impact factor: 1.641, year: 2016

Teatrikunstnik Andrea Haamer: Olen alati unistanud Eestisse tagasi tulla / Andrea Haamer ; intervjueerinud Andreas Sepp, Anneli Sihvart

Index Scriptorium Estoniae

Haamer, Andrea

2011-01-01

Eesti juurtega lava- ja kostüümikunstnikust Andrea T. Haamerist, kes on Eestis kujundanud kolm balletti. 25. veebruaril avatavast neljandast Jõhvi balletifestivalist, kus avatakse Andrea Haameri näitus

Autobiografia di un fisico

CERN Document Server

Born, Max

1980-01-01

Questa non è solo un'autobiografia scientifica. Il ritratto che Max Born ci offre di se stesso va oltre il profilo dell'uomo di scienza, che pure è stato tra i maggiori del nostro secolo. Di lui veniamo a sapere tutto ciò che occorre per accostarsi alle teorie che gli valsero il premio Nobel, ma anche i tratti di una normale vita borghese nella quale si intrecciavano le influenze dell'ambiente intellettuale e commerciale. Il tono è quello di una rievocazione piana e distesa che ci accompagna per le varie fasi della carriera dello studente, del docente, dello scienziato, nelle università tedesche e inglesi, negli anni delle persecuzioni naziste, alle quali l'ebreo Max Born ebbe la fortuna di sopravvivere, e nel dopoguerra, quando egli tornò in Germania e seppe dare un contributo di idee e di iniziative ai movimenti pacifisti. E' la lunga e operosa vita di un uomo di genio, del quale si ricorda la profonda umanità, la vastità degli interessi culturali, l'acutezza dei giudizi sulle persone, sulle vicend...

Eesti otsib globaalsel kinnisvaraturul oma kohta. Kas Tallinn on naabritest parim? / Olev Mait Makk ; intervjueerinud Lemmi Kann

Index Scriptorium Estoniae

Makk, Olev Mait

2011-01-01

Intervjuu Cannes'is globaalsel kinnisvaramessil ja konverentsil MIPIM 2011 viibinud Seven Real Estate Advisors partneri, investeeringute ja nõustamisvaldkonna juhiga. Kinnisvara puhul on välisinvestorite poolt eelistatud sihtriik nn. uue Euroopa riikide seas Poola. Välisinvestorite suurim huvi Eestis on stabiilset rahavoogu tootvate büroo- ja kaubanduskeskuste vastu

Role of innate T cells in anti-bacterial immunity

Directory of Open Access Journals (Sweden)

Yifang eGao

2015-06-01

Full Text Available Innate T cells are a heterogeneous group of αβ and γδ T cells that respond rapidly (<2 hours upon activation. These innate T cells also share a non MHC class I or II restriction requirement for antigen recognition. Three major populations within the innate T cell group are recognized, namely Invariant NKT cells (iNKT; Mucosal associated invariant T cells (MAIT and gamma delta T cells. These cells recognize foreign/self-lipid presented by non-classical MHC molecules, such as CD1d, MR1 and CD1a.They are activated during the early stages of bacterial infection and act as a bridge between the innate and adaptive immune systems. In this review we focus on the functional properties of these 3 innate T cell populations and how they are purposed for antimicrobial defense. Furthermore we address the mechanisms through which their effector functions are targeted for bacterial control and compare this in human and murine systems. Lastly we speculate on future roles of these cell types in therapeutic settings such as vaccination.

Lootus : [luuletused] / Friedrich Schiller ; tlk. Ain Kaalep, Rein Sepp, Paul Viiding, Eduard Roos, Jaan Kross, Jakob Tamm

Index Scriptorium Estoniae

Schiller, Friedrich, 1759-1805

2006-01-01

Sisu: Lootus ; Õhtu ; Brutus ja Caesar ; Laura klaveri ees ; Rousseau ; Grupp Tartarosest ; Rõõmule ; Palvekiri ; Hektori lahkumine ; Kunstnikud ; Laulu võim ; Metafüüsik ; Ideaal ja elu ; Maailma jaotamine ; Neiu võõrsilt ; Külvaja ; Odysseus ; Kolumbus ; Antiikkultuur rändurile Põhjast ; Zeus Heraklesele ; Kõrgeim ; Laps hällis ; Surematus ; Võti ; Astronoomilised teosed ; Parim riik ; Minu usk ; Sõber ja vaenlane ; Harv seos ; Nooruse lätted ; Naiste otsus ; Ootus ja täitumine ; Ühine saatus ; Looduseuurijad ja transtsendentaalfilosoofid ; Ohtlik tulemus ; Anonüümne jõgi ; Valgus ja soojus ; Neiu kaebus ; Ühele moralistile ; Goethele ; Pagulane ; Saksa muusa ; Uue sajandi saabumine ; Punshilaul ; Mäelaul ; Polykratese sõrmus ; Rüütel Toggenburg ; Kinnas ; Alpi kütt ; Sõpradele. Eluloolisi andmeid autori kohta lk. 239

CD8αα expression marks terminally differentiated human CD8+ T cells expanded in chronic viral infection

Directory of Open Access Journals (Sweden)

Lucy Jane Walker

2013-08-01

Full Text Available The T cell co-receptor CD8αβ enhances T cell sensitivity to antigen, however studies indicate CD8αα has the converse effect and acts as a co-repressor. Using a combination of Thymic Leukaemia antigen (TL tetramer, which directly binds CD8αα, anti-CD161 and anti-Vα7.2 antibodies we have been able for the first time to clearly define CD8αα expression on human CD8 T cells subsets. In healthy controls CD8αα is most highly expressed by CD161 bright (CD161++ mucosal associated invariant T (MAIT cells, with CD8αα expression highly restricted to the TCR Vα7.2+ cells of this subset. We also identified CD8αα-expressing populations within the CD161 mid (CD161+ and negative (CD161- non-MAIT CD8 T cell subsets and show TL-tetramer binding to correlate with expression of CD8β at low levels in the context of maintained CD8α expression (CD8α+CD8βlow. In addition, we found CD161-CD8α+CD8βlow populations to be significantly expanded in the peripheral blood of HIV-1 and hepatitis B (mean of 47% and 40% of CD161- T cells respectively infected individuals. Such CD8αα expressing T cells are an effector-memory population (CD45RA-, CCR7-, CD62L- that express markers of activation and maturation (HLA-DR+, CD28-, CD27-, CD57+ and are functionally distinct, expressing greater levels of TNF-α and IFN-γ on stimulation and perforin at rest than their CD8α+CD8βhigh counterparts. Antigen-specific T cells in HLA-B*4201+HIV-1 infected patients are found within both the CD161-CD8α+CD8βhigh and CD161-CD8α+CD8βlow populations. Overall we have clearly defined CD8αα expressing human T cell subsets using the TL-tetramer, and have demonstrated CD161-CD8α+CD8βlow populations, highly expanded in disease settings, to co-express CD8αβ and CD8αα. Co-expression of CD8αα on CD8αβ T cells may impact on their overall function in-vivo and contribute to the distinctive phenotype of highly differentiated populations in HBV and HIV-1 infection.

2013. aasta preemiate žürii kommentaar = Comments from 2013 annual prize panel of judges / Mait Väljas

Index Scriptorium Estoniae

Väljas, Mait

2015-01-01

Eesti kultuurkapitali aastapreemia 2013 Tartu Ülikooli Narva Kolledžile. Arhitektuuri sihtkapitali arhitektuuripreemia Viljandi Riigigümnaasiumile, arhitektuuri eripreemia Kukemõisa karjamõisale, sisearhitektuuripreemia Tallinna Ülikooli BFMi õppehoonele, maastikuarhitektuuripreemia Eesti Ajaloomuuseumi väliekspositsioonile "Klooga laager ja holokaust", innovatsioonipreemia Passion House moodulmajale, arhitektuurialase tegevuse preemia Triin Ojarile ja disainipreemia Matti Õunapuule roller Stigo eest

Tasakaalus tulemuskaardi sage viga on vääralt määratud näitajad / Mait Raava

Index Scriptorium Estoniae

Raava, Mait

2003-01-01

Tasakaalus tulemuskaart väljendab strateegiliste tulemusnäitajate põhjuslik-tagajärjelisi seoseid, kuid viga tuleb sageli nende tegurite määratlemisel, kirjutab autor. Skeem. Kommenteerib Sven Heil

Laurentiuse kirik päästab Saueri oreli osi niiskuse käest / Andres Sepp ; kommenteerinud Anti Toplaan

Index Scriptorium Estoniae

Sepp, Andres, 1976-

2009-01-01

Kuressaare Laurentiuse kiriku kogudus otsib võimalusi viia 1881. a. Wilhelm Saueri firmas valminud vanima Eestis säilinud oreli puidust ja metallist osad kuivemasse kohta. Praegu seisavad need kiriku garaažis

Konkurentsipoliitika infrastruktuursetes erandvaldkondades Eesti näitel: loomuliku monopoli ja universaalteenuste põimumine / Jüri Sepp, Diana Eerma

Index Scriptorium Estoniae

Sepp, Jüri, 1952-

2011-01-01

Artikli eesmärgiks on süstematiseerida ja hinnata erandvaldkondade reguleerimise majanduspoliitilisi meetmeid, kõrvutatakse eri valdkondade lahendusi omavahel ja normatiivse teooria seisukohtadega. Tabel

7th Symposium on Computational Statistics

CERN Document Server

Lauro, N; Rizzi, A

1986-01-01

When dealing with the design or with the application of any technical system, which is not quite simple and trivial, one has to face to the problem to determine the allowable de­ viations of the system functions and the optimal vector of system parameter tolerances. The need for the solution of this problem is stimulated with various serious economic and maite­ nance aspects, between them the tendency to reach the minimal production cost, the maximal system operation reliability are the most frequent. Suppose that we are dealing with an system S, consisting of N components represented by the system parame­ ters xi' i = 1, 2 . . . N, which are arranged in certain structu­ re so, that the K, system functions F k' k = 1, 2 . . . IG , expres­ sing the considered system properties, fullfil the condition F-FO~ AF, /1/ \\'Ihere F = l F k} Ie is the set of the actual system functions, FO = lFOk}~ is the set of the nominal system functions and A F = l A F k 1(;. } is the set 0 f the a 11 0 w a b 1 e s emf y s t u ...

Design of an x-ray telescope optics for XEUS

Science.gov (United States)

Graue, Roland; Kampf, Dirk; Wallace, Kotska; Lumb, David; Bavdaz, Marcos; Freyberg, Michael

2017-11-01

The X-ray telescope concept for XEUS is based on an innovative high performance and light weight Silicon Pore Optics technology. The XEUS telescope is segmented into 16 radial, thermostable petals providing the rigid optical bench structure of the stand alone XRay High Precision Tandem Optics. A fully representative Form Fit Function (FFF) Model of one petal is currently under development to demonstrate the outstanding lightweight telescope capabilities with high optically effective area. Starting from the envisaged system performance the related tolerance budgets were derived. These petals are made from ceramics, i.e. CeSiC. The structural and thermal performance of the petal shall be reported. The stepwise alignment and integration procedure on petal level shall be described. The functional performance and environmental test verification plan of the Form Fit Function Model and the test set ups are described in this paper. In parallel to the running development activities the programmatic and technical issues wrt. the FM telescope MAIT with currently 1488 Tandem Optics are under investigation. Remote controlled robot supported assembly, simultaneous active alignment and verification testing and decentralised time effective integration procedures shall be illustrated.

Smoking reduces circulating CD26hi CD161hi MAIT cells in healthy individuals and patients with multiple sclerosis

DEFF Research Database (Denmark)

Ammitzbøll, Cecilie; Börnsen, Lars; Romme Christensen, Jeppe

2017-01-01

Upon chronic cigarette smoke exposure, inhaled antigens and irritants cause altered lung immune homeostasis. Circulating immune cells are affected, and smoking is associated with an increased risk of developing various disorders, including multiple sclerosis (MS). This study was conducted......-induced proliferation and cytokine secretion in smokers and nonsmokers in a cohort of 100 healthy individuals (HI). In addition, we analyzed immune cell subsets associated with smoking in 2 independent cohorts of patients with MS. In HI smokers compared with nonsmokers, we found increased blood cell counts...... to determine the impact of smoking on circulating immune cell subsets. Furthermore, we determined whether any smoking-associated changes were related to MS. With the use of flow cytometry, CFSE assays, and ELISpot assays, we analyzed circulating immune cell phenotypes and quantified antigen...

Fotokuu näituse kuraator Adam Budak on ühendanud filmi, arhitektuuri ja filosoofia / Adam Budak ; intervjueerinud Andreas Sepp

Index Scriptorium Estoniae

Budak, Adam, 1966-

2011-01-01

Kumu Kunstimuuseumis 8. jaanuarini 2012 avatud rahvusvahelise kaamerakunsti näituse "Teisele poole" kuraator kaasaegse kunsti kuraatori tööst, näituse "Teisele poole" kureerimise lähtekohtadest, varasematest kokkupuudetest Tallinnaga, endast, kolimisest Ameerikasse jm.

Kohustiste täitmine ja tagamise vahendid : [bakalaureusetöö] / Marek Sepp ; Tartu Ülikool, õigusteaduskond ; juhendaja: Irene Kull

Index Scriptorium Estoniae

Sepp, Marek

1994-01-01

Kohustiste täitmine, nõuetekohase täitmise printsiip, vastastikune täitmine, deponeerimine, kohustiste täitmine natuuras; kohustiste täitmise tagamine (käendus, garantii, leppetrahv, käsiraha, pant)

Magistritööde kaitsmine : [Maria-Magdalena Jürvetson jt.

Index Scriptorium Estoniae

1999-01-01

14. juunil '99 kaitsevad TPÜ filoloogiateaduskonna magistritööde kaitsmisnõukogu koosolekul Maria-Magdalena Jürvetson magistritöö "Soome keele ja rahvuskultuuri areng 19. sajandil" ja Hilve Rebase magistritöö "Norra ja Soome kirjanike loomingust ja retseptsioonist Eestis"; 15. juunil kaitsevad TPÜ infoteaduste osakonna magistritööde kaitsmisnõukogu koosolekul Aivi Sepp magistritöö "Raamatukogu- ja infoteaduslik haridus 20. sajandi teisel poolel" ja Marianne Paimre magistritöö "Narkotemaatika Eesti loetavamates päevalehtedes aastatel 1993-1995 : bibliomeetriline aspekt"; 17. juunil kaitsevad TPÜ geoökoloogia magistritööde kaitsmisnõukogu koosolekul Raimo Pajula magistritöö "Raba mikromaastike seosed rabalaama morfomeetria ja veerežiimiga Männik-järve raba näitel", Kristjan Kruusement magistritöö "Fosfori jaotus järvesetetes" ja Peep-Aarne Sirge magistritöö "Eesti endiste sõjakoolide kogemuste rakendamise võimalusi kaitsejõudude tänapäevases väljaõppes"; 21. juunil kaitsevad TPÜ kasvatusteaduste ja pedagoogika magistritööde kaitsmisnõukogu koosolekul Krista Loogma magistritöö "Stsenaariumi meetodi rakendamine hariduse tuleviku uurimisel ja haridusstrateegia arendamisel" ja Tarmo Salumaa magistritöö "Eesmärgistatud organisatsiooniliste muutuste mõju inimeste töökeskkonna tunnetamisele koolis"

Efectos de la aplicación de soluciones de cloruro de calcio (CaCl2

Directory of Open Access Journals (Sweden)

Galvis Jesús Antonio

2003-12-01

Full Text Available

Se cosecharon mangos de la variedad Van

Dyke en su estado de madurez fisiológica en la finca Frutol,

localizada en el municipio de El Espinal, departamento

del Tolima, situado a una altura de 431 m.s.n.m., con

precipitación promedio anual de 1.368 mm, temperatura

promedio de 29° C y humedad relativa (HR promedio

del 70%. Los frutos se seleccionaron por su sanidad y grado

de madurez, y se llevaron al laboratorio de poscosecha

de la Planta Piloto de Vegetales del ICTA de la Universidad

Nacional, sede Bogotá, donde fueron lavados y desinfectados.

Posteriormente se sumergieron en soluciones de

Stereofractographic investigation of static start and dynamic jump of a fatigue crack in pressure vessel steel

International Nuclear Information System (INIS)

Stepanenko, V.A.; Shtukaturova, A.S.; Yasnij, P.V.; AN Ukrainskoj SSR, Kiev. Inst. Problem Prochnosti)

1983-01-01

Results of investigaytion have been discussed ipto the effect of certain temperature-force factors on regularities in the formation of stretch zones during the crack initiation static and transition zones at crack jumps in the process of cyclic loading. The 15Kh2NMFA pressure vessel steel has been investigated. The steel fracture toughnesKub(Ic) has been determined testing s the specimens for excentric stretching or a bending through an angle. It has been shown that transition zones in a front of fatique cracks at the jump beginning and end are formed through the shift mechanism owing to the material separation along the maximum failure zone contour, i.e. along the plastic zone contour in a crack vertex. This is the mait difference of regularities in the formation of the transition zones during fatique crack jumps from stretching zones formed through the break-away mechanism of crack vertex bluntness during its static move. It is noted that a final conclusion on the mechanism of transition zone formation during fartique crack jumps allows one to perform systematic investigation into the plastic zone configuration in a fatique crack verteX and stereofractographic measurement of two identically conjugate jump surfaces on opposite fractures of the same samples

CD1 and mycobacterial lipids activate human T cells.

Science.gov (United States)

Van Rhijn, Ildiko; Moody, D Branch

2015-03-01

For decades, proteins were thought to be the sole or at least the dominant source of antigens for T cells. Studies in the 1990s demonstrated that CD1 proteins and mycobacterial lipids form specific targets of human αβ T cells. The molecular basis by which T-cell receptors (TCRs) recognize CD1-lipid complexes is now well understood. Many types of mycobacterial lipids function as antigens in the CD1 system, and new studies done with CD1 tetramers identify T-cell populations in the blood of tuberculosis patients. In human populations, a fundamental difference between the CD1 and major histocompatibility complex systems is that all humans express nearly identical CD1 proteins. Correspondingly, human CD1 responsive T cells show evidence of conserved TCRs. In addition to natural killer T cells and mucosal-associated invariant T (MAIT cells), conserved TCRs define other subsets of human T cells, including germline-encoded mycolyl-reactive (GEM) T cells. The simple immunogenetics of the CD1 system and new investigative tools to measure T-cell responses in humans now creates a situation in which known lipid antigens can be developed as immunodiagnostic and immunotherapeutic reagents for tuberculosis disease. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Immunology in the liver--from homeostasis to disease.

Science.gov (United States)

Heymann, Felix; Tacke, Frank

2016-02-01

The liver is a central immunological organ with a high exposure to circulating antigens and endotoxins from the gut microbiota, particularly enriched for innate immune cells (macrophages, innate lymphoid cells, mucosal-associated invariant T (MAIT) cells). In homeostasis, many mechanisms ensure suppression of immune responses, resulting in tolerance. Tolerance is also relevant for chronic persistence of hepatotropic viruses or allograft acceptance after liver transplantation. The liver can rapidly activate immunity in response to infections or tissue damage. Depending on the underlying liver disease, such as viral hepatitis, cholestasis or NASH, different triggers mediate immune-cell activation. Conserved mechanisms such as molecular danger patterns (alarmins), Toll-like receptor signalling or inflammasome activation initiate inflammatory responses in the liver. The inflammatory activation of hepatic stellate and Kupffer cells results in the chemokine-mediated infiltration of neutrophils, monocytes, natural killer (NK) and natural killer T (NKT) cells. The ultimate outcome of the intrahepatic immune response (for example, fibrosis or resolution) depends on the functional diversity of macrophages and dendritic cells, but also on the balance between pro-inflammatory and anti-inflammatory T-cell populations. As reviewed here, tremendous progress has helped to understand the fine-tuning of immune responses in the liver from homeostasis to disease, indicating promising targets for future therapies in acute and chronic liver diseases.

The Effect of Mercury Mining Activities on Oak Forest in the Almaden Area

International Nuclear Information System (INIS)

Villadoniga, M.; Sierra, M. J.; Millan, R.

2009-01-01

This scientific-technical report is the result of the research work carried out by Maite Villadoniga Garcia, to obtain the Master's Final Project, this has been developed at the Unit of Soil Degradation in the Department of Environment at CIEMAT. Two main reasons are important for the study of the vegetation in Almaden, firstly to ascertain the state in which they find the different landscapes surrounding the mine and secondly, it would be interesting to know the potential applications for recovery areas, degraded by this type of mining. This report presents the initial analysis of a natural area where there has not been activity related to mining of mercury, but their lithologic conditions and proximity to the mine of Almaden (within 3 km) make it a space in which they are both elevated mercury concentrations in soil (1.25 to 35.55 mg kg - 1) and plant species (Quercus ilex: 0.10-2.29 mg kg - 1; Pseudovernia sp. 1.10-21.06 mg kg - 1). We can conclude after this study that the natural vegetation of the area if they had been affected by years of mining, although not find any obvious signs of damage to these ecosystems and that different factors affect the uptake of mercury by of different species. (Author) 37 refs.

Jaan Ehlvest soovi(ta)b mudast tõusta / Jaan Ehlvest ; intervjueerinud Valeri Maksimov ; kommenteerivad: Jaak Allik, Valter Heuer, Olav Sepp

Index Scriptorium Estoniae

Ehlvest, Jaan, 1962-

1998-01-01

Intervjuu Jaan Ehlvestiga olukorrast nii Eesti kui maailma males pärast maleolümpiat Elistas, kus Eesti meeskond jäi 40. kohale ning selle tulemusega ei olnud rahul ei meeskond ega ka Eesti Maleliit

A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?

Directory of Open Access Journals (Sweden)

Carmela R. Balistreri

2018-01-01

Full Text Available Bicuspid valve disease is associated with the development of thoracic aortic aneurysm. The molecular mechanisms underlying this association still need to be clarified. Here, we evaluated the circulating levels of T and B lymphocyte subsets associated with the development of vascular diseases in patients with bicuspid aortic valve or tricuspid aortic valve with and without thoracic aortic aneurysm. We unveiled that the circulating levels of the MAIT, CD4+IL−17A+, and NKT T cell subsets were significantly reduced in bicuspid valve disease cases, when compared to tricuspid aortic valve cases in either the presence or the absence of thoracic aortic aneurysm. Among patients with tricuspid aortic valve, these cells were higher in those also affected by thoracic aortic aneurysm. Similar data were obtained by examining CD19+ B cells, naïve B cells (IgD+CD27−, memory unswitched B cells (IgD+CD27+, memory switched B cells (IgD−CD27+, and double-negative B cells (DN (IgD−CD27−. These cells resulted to be lower in subjects with bicuspid valve disease with respect to patients with tricuspid aortic valve. In whole, our data indicate that patients with bicuspid valve disease show a quantitative reduction of T and B lymphocyte cell subsets. Future studies are encouraged to understand the molecular mechanisms underlying this observation and its pathophysiological significance.

Žemaitės feminizmas. Žemaitė’s Feminism

Directory of Open Access Journals (Sweden)

Dalia Čiočytė

2009-01-01

Full Text Available The biography of Julija Beniuševičiūtė-Žymantie­nė – Žemaitė (1845–1921, one of the greatest Lithu­anian Realists, has got a broad accent of feminist ac­tivity. Some short stories written by Žemaitė express feminist ideas with publicistic pathos (In Town, „Mieste“, 1905, Mister Zigmantas, „Ponas Zigman­tas“, and others. In her short story Eve („Ieva“ Že­maitė presents an interesting ironic interpretation of the biblical archetype. Žemaitė’s best literary visions of women’s infelicity varies the topos of a quiet / silent / silenced woman and interestingly imply some gap between feminist ideology and literary meaning. In the short stories The Daughter-in-Law („Marti“, 1896, They Didn’t Have a Good Mother („Neturėjo geros motinos“, 1895 the reason of misfortunes se­ems to be deeper than just women being oppressed by men in the patriarchal society. The patriarchal op­pression of women is constructed as a metonymy of the philosophical evil. The short story Sutkai (1897 may be interpreted as a literary vision of a feminine utopia: woman’s identity here is defined rather as wholeness than “otherness”.

The Effect of Mercury Mining Activities on Oak Forest in the Almaden Area; El Encinar en el Distrito Minero de Almaden y su Afectacion por la Mineria del Mercurio

Energy Technology Data Exchange (ETDEWEB)

Villadoniga, M.; Sierra, M.J.; Millan, R.

2009-07-01

This scientific-technical report is the result of the research work carried out by Maite Villadoniga Garcia, to obtain the Master's Final Project, this has been developed at the Unit of Soil Degradation in the Department of Environment at CIEMAT. Two main reasons are important for the study of the vegetation in Almaden, firstly to ascertain the state in which they find the different landscapes surrounding the mine and secondly, it would be interesting to know the potential applications for recovery areas, degraded by this type of mining. This report presents the initial analysis of a natural area where there has not been activity related to mining of mercury, but their lithologic conditions and proximity to the mine of Almaden (within 3 km) make it a space in which they are both elevated mercury concentrations in soil (1.25 to 35.55 mg kg{sup -}1) and plant species (Quercus ilex: 0.10-2.29 mg kg{sup -}1; Pseudovernia sp. 1.10-21.06 mg kg{sup -}1). We can conclude after this study that the natural vegetation of the area if they had been affected by years of mining, although not find any obvious signs of damage to these ecosystems and that different factors affect the uptake of mercury by of different species. (Author) 37 refs.

The Effect of Mercury Mining Activities on Oak Forest in the Almaden Area; El Encinar en el Distrito Minero de Almaden y su Afectacion por la Mineria del Mercurio

Energy Technology Data Exchange (ETDEWEB)

Villadoniga, M; Sierra, M J; Millan, R

2009-07-01

This scientific-technical report is the result of the research work carried out by Maite Villadoniga Garcia, to obtain the Master's Final Project, this has been developed at the Unit of Soil Degradation in the Department of Environment at CIEMAT. Two main reasons are important for the study of the vegetation in Almaden, firstly to ascertain the state in which they find the different landscapes surrounding the mine and secondly, it would be interesting to know the potential applications for recovery areas, degraded by this type of mining. This report presents the initial analysis of a natural area where there has not been activity related to mining of mercury, but their lithologic conditions and proximity to the mine of Almaden (within 3 km) make it a space in which they are both elevated mercury concentrations in soil (1.25 to 35.55 mg kg{sup -}1) and plant species (Quercus ilex: 0.10-2.29 mg kg{sup -}1; Pseudovernia sp. 1.10-21.06 mg kg{sup -}1). We can conclude after this study that the natural vegetation of the area if they had been affected by years of mining, although not find any obvious signs of damage to these ecosystems and that different factors affect the uptake of mercury by of different species. (Author) 37 refs.

Transcriptomics of maternal and fetal membranes can discriminate between gestational-age matched preterm neonates with and without cognitive impairment diagnosed at 18-24 months.

Directory of Open Access Journals (Sweden)

Athina Pappas

Full Text Available Neurocognitive impairment among children born preterm may arise from complex interactions between genes and the intra-uterine environment.(1 To characterize the transcriptomic profiles of chorioamniotic membranes in preterm neonates with and without neurocognitive impairment via microarrays and (2 to determine if neonates with neurocognitive impairment can be identified at birth.A retrospective case-control study was conducted to examine the chorioamniotic transcriptome of gestational-age matched very preterm neonates with and without neurocognitive impairment at 18-24 months' corrected-age defined by a Bayley-III Cognitive Composite Score 1.5; 2 Gene ontology analysis indicated enrichment of 19 biological processes and 3 molecular functions; 3PADOG identified 4 significantly perturbed KEGG pathways: oxidative phosphorylation, Parkinson's disease, Alzheimer's disease and Huntington's disease (q-value <0.1; 4 48 of 90 selected differentially expressed genes were confirmed by qRT-PCR, including genes implicated in energy metabolism, neuronal signaling, vascular permeability and response to injury (e.g., up-regulation of SEPP1, APOE, DAB2, CD163, CXCL12, VWF; down-regulation of HAND1, OSR1(p<0.05; and 5 a multi-gene model predicted 18-24 month neurocognitive impairment (using the ratios of OSR1/VWF and HAND1/VWF at birth in a larger, independent set (sensitivity = 74%, at specificity = 83%.Gene expression patterns in the chorioamniotic membranes link neurocognitive impairment in preterm infants to neurodegenerative disease pathways and might be used to predict neurocognitive impairment. Further prospective studies are needed.

Näitlejad ühes mullis, esietendus ukse ees / Hendrik Toompere jr. jr., Liisa Pulk, Mait Joorits ... [jt.] ; intervjueerinud Liisi Seil ; kommenteerinud Helle Leppik

Index Scriptorium Estoniae

2010-01-01

Vestlus Eesti muusika- ja teatriakadeemia lavakunstikooli XXIV lennu tudengitega, kelle lõputöö Tom Stoppardi näidend "Arkaadia" etendub Ugala laval. Lisatud Ugala teatri kirjandustoimetaja arvamus

HIPPI: highly accurate protein family classification with ensembles of HMMs

Directory of Open Access Journals (Sweden)

Nam-phuong Nguyen

2016-11-01

Full Text Available Abstract Background Given a new biological sequence, detecting membership in a known family is a basic step in many bioinformatics analyses, with applications to protein structure and function prediction and metagenomic taxon identification and abundance profiling, among others. Yet family identification of sequences that are distantly related to sequences in public databases or that are fragmentary remains one of the more difficult analytical problems in bioinformatics. Results We present a new technique for family identification called HIPPI (Hierarchical Profile Hidden Markov Models for Protein family Identification. HIPPI uses a novel technique to represent a multiple sequence alignment for a given protein family or superfamily by an ensemble of profile hidden Markov models computed using HMMER. An evaluation of HIPPI on the Pfam database shows that HIPPI has better overall precision and recall than blastp, HMMER, and pipelines based on HHsearch, and maintains good accuracy even for fragmentary query sequences and for protein families with low average pairwise sequence identity, both conditions where other methods degrade in accuracy. Conclusion HIPPI provides accurate protein family identification and is robust to difficult model conditions. Our results, combined with observations from previous studies, show that ensembles of profile Hidden Markov models can better represent multiple sequence alignments than a single profile Hidden Markov model, and thus can improve downstream analyses for various bioinformatic tasks. Further research is needed to determine the best practices for building the ensemble of profile Hidden Markov models. HIPPI is available on GitHub at https://github.com/smirarab/sepp .

Euroopa Inimõiguste Kohtu (suurkoja) otsus asjas Kononov vs. Läti (kaebus nr 36376/04) / Lauri Mälksoo ; inglise keelest tõlkinud Mait Laaring

Index Scriptorium Estoniae

Mälksoo, Lauri, 1975-

2011-01-01

17. mail 2010 tegi Euroopa Inimõiguste Kohtu suurkoda otsuse asjas Kononov vs. Läti, otsustades, et Läti ei rikkunud Euroopa inimõiguste ja põhivabaduste kaitse konventsiooni artiklit 7, kui mõistis Vassili Kononovi süüdi Teise maailmasõja ajal Lätis toimepandud sõjakuriteos

Žanr : suvelavastus? / Jaak Allik

Index Scriptorium Estoniae

Allik, Jaak, 1946-

2007-01-01

Kahekümnest suvisest teatriõhtust: Carlo Gozzi "Ronk" Tallinna Linnateatri lavaaugus (lavastaja Elmo Nüganen), Komöödiateatri suvetuuri lavastus "Elu parim puhkus" (lavastaja Ago-Endrik Kerge), muusikal "Tutvumiskuulutus" (lavastaja Mait Malmsten), Bernard Kangermanni laulumäng "Naabri Mari" (lavastaja Margus Vaher) ja Mara Zalite "Sirelikassid" (lavastaja Peeter Tammearu) Ugalas, Paul Barzi komöödia "Võimalik kohtumine" (lavastaja Raivo Trass) Vanemuise teatri suvelavastus Muhumaal Pädaste mõisas, muusikaline estraadietendus "Tähtede sadu", Endla "Tsirkus!!!" Paikuse-Reiu vabaõhulaval (autor ja lavastaja Tiit Palu), Andrus Kivirähki näidend "Uljas Neitsi" Laulasmaa Resort' rannametsas (lavastaja Taavi Teplenkov), Marti Kivastik "Eesti asi" (lavastaja Ingomar Vihmar) MTÜ Ühendus R.A.A.A.M. Viinistu kunstimuuseumi vabaõhulaval, Emajõe Suveteatri suvelavastus "Jumalaema kiriku kellamees" Victor Hugo romaani järgi (lavastaja Andres Dvinjaninov), "Muna EÜE ehk Viimane kava" (autor Lauri Vahtre, lavastaja Andrus Vaarik) Suure Munamäe vabaõhulaval, Aino Kalda "Reigi õpetaja" Kuressaares (lavastaja ja dramatiseerija Aare Toikka), Vana Baskini Teateris Pierre Chesnot "Kes aevastas?" (lavastaja Eino Baskin), Eduard Vilde romaani "Prohvet Maltsvet" ja vene kirjaniku Viktor Pelevini romaani aineil sündinud lavastus "Proffet" Albu vallas Kukenoosi rehealuses (lavastaja Mart Koldits), Enn Vetemaa "Roosiaed" Raasiku vallas Kiviloo mõisas (lavastaja Eva Klemets), Jim Ashilevi "Portselansuits" (lavastaja Lauri Lagle) Eesti Teatriliidu saalis, Andres Keili "Rooside sõda" Leigo Järveteatris (lavastaja Tõnu Lensment), Võru Teatriateljee suvelavastus Madis Kõivu "Castrozza ehk illusionist" (lavastaja Taago Tubin), Villu Tamme "Haned võlgu" (lavastaja ja kunstnik Jaanika Juhanson) Teatrilabor Von Krahli teatris

What Intellectual Property Lawyers can learn from Barbra Streisand, Sepp Blatter, and the "Coca-Cola Cry-Baby": Dealing with "Trademark Bullying" in South Africa

Directory of Open Access Journals (Sweden)

André M Louw

2013-12-01

Full Text Available This article suggests some pause for reflection amongst intellectual property lawyers, and for serious consideration of the words of an internationally-renowned IP law expert: "Possessing a right does not mean that it is a good idea to enforce it always, and to the hilt. Discretion may be nine parts of possession". It provides some prominent, recent examples of trademark bullying or overly-aggressive enforcement in the IP law context. These examples are mainly from other jurisdictions but they are directly relevant to some of the IP law challenges present in South Africa at the moment. The article further examines why lawyers and rights' holders engage in trademark bullying (why it's done, and start to deal briefly with some of the legal implications. A future article is to examine the legal aspects of trademark bullying in much more detail and considers its legitimacy within the context of IP law, more generally, and some other areas of law, more specifically.

What Intellectual Property Lawyers can learn from Barbra Streisand, Sepp Blatter, and the "Coca-Cola Cry-Baby": Dealing with "Trademark Bullying" in South Africa

OpenAIRE

André M Louw

2013-01-01

This article suggests some pause for reflection amongst intellectual property lawyers, and for serious consideration of the words of an internationally-renowned IP law expert: "Possessing a right does not mean that it is a good idea to enforce it always, and to the hilt. Discretion may be nine parts of possession". It provides some prominent, recent examples of trademark bullying or overly-aggressive enforcement in the IP law context. These examples are mainly from other jurisdictions but the...

Aasta 1998 Tallinna Pedagoogikaülikoolis : [kroonika] / koost. Merike Määrits

Index Scriptorium Estoniae

1999-01-01

Ülevaateartikkel TPÜ tähtsamatest sündmustest 1998.a. ja lõpetajate nimekiri. 13. märtsil̀98 toimus filoloogiateaduskonnas emakeelepäev. 29.apr.̀98 parafraseerisid Roueni ülikool ja TPÜ koostöö põhiprintsiibid. 5. mail̀98 korraldas TPÜ rektoraat vastuvõtu Eesti meistrivõistluste II koha saanud korv- ja võrkpallinaiskonnale. 4. nov.̀98 avati TPÜ filoloogiateaduskonnas slavistika kabinet. 7., 8. mail̀98 toimus TPÜ kultuuriteaduskonna korraldusel teaduskonverents "Eesti kultuur 1940. aastate teisel poolel". 28. jaan.̀98 avati TPÜs Euroopa Ülikoolide Infokeskus. 2. sept.̀98 avati TPÜ Haapsalu Kolledž. 5. okt.̀98 tähistat TPÜ-s õpetajate päeva. EV presidendi vastuvõtul käisid 1998.a. TPÜ cum laude lõpetanud üliõpilased. 3. dets.̀98 korraldas TPÜ rektor Mait Arvisto vastuvõtu ülikooli üliõpilaste teadustööde konkursi võitjatele ja nende juhendajatele. 27. veebr.̀98, sotsiaalteaduskonna päeval anti teaduskonna õppejõududele üle õppejõupreemid. 16. okt.̀98 tähistati piduliku aktusega TPÜ 79. aastapäeva. TPÜ lõpetajad 1998. 7.-8.dets.̀98 korraldas TPÜ sotsiaaltöö osakond koostöös sotsiaalministeeriumi vanuripoliitika komisjoniga konverentsi "Ühiskond igale eale". EV haridusministeeriumi poolt korraldatud üliõpilaste teadustööde konkursil tunnistati Reimo Rivise töö ama alagrupis III preemia vääriliseks, diplomid said Krista Kalberg, Mihkel Märtin, Maris Pallas, Kaire Parts, Merle Talvik. 16. dets.̀98 avasid Prantsusmaa suursaadik Jacques Subrenat ja kultuuriatašee Catherine Suard prantsuse keele lektoraadi

Luuleaasta 1994 : parlamendi koosseis on selgunud / Barbi Pilvre

Index Scriptorium Estoniae

Pilvre, Barbi, 1963-

1995-01-01

Rannit, Aleksis. Nii näen sind ikka; Kangur, Kalju. Sõna sees olek; Traat, Mats. Koidu kätes; Rimmel, Rudolf. Setu netu; Suislepp, Harald. Köögertali kojutulek; Piir, Enno. Sunnitöölise Mekka; Üllaste, Leenart. Lind tormis; Hirv, Indrek. Taskuraamat (taskutähekerjus); Mirtem, Valev [Luhaäär, Ingvar]. Maithunad Eestis; Mirtem, Valev [Luhaäär, Ingvar]. Armuühtepühad; Mirtem, Valev [Luhaäär, Ingvar]. Tulevaas; Kurvits, Lembit. Matle laul; Lillemets, Enn. Olemise valge koer ehk Ingli kolju; Jessod, Mats [Jakobson, Mati]. Jah, luuletused; Jessod, Mats [Jakobson, Mati]. Ohjad Oti mäel; Jessod, Mats [Jakobson, Mati]. Poeetilisi prohmakaid; Ivar, Ivo. Riimiskid; Kilokalor, Kalle. Öösel näeb halvemini kui päeval; Trubetsky, Tõnu. Anarhia; Laanvee, Ervin. Jaa. Mina olen; Kuningas, Marko J. ...jääb USK, LOOTUS, ARMASTUS; Ruben, Arne. Ajakirjanik; Ollinovski, Jim [Ollino, Ott]. Luuletused; Toomik, Tõnu. 27 luuletust; Tosin, Ants. Õnnetähestik; Krüger, Urmas. Ka nii võib...; Kärner, Siim. Usseaid; Sikk, Heino. Võrokõstõlõ: poeem; Kollin, Viktor. Kodutunne; Alo, Ülo [Võsar, Ülo Alo]. Ööbikuvalgus; Sepp, Vello. Vigased pärlid; Palo, Wilhelm. Tuule-luuled; Soomets, Triin. Randmes unejanu; Soomets, Triin. Janu masinas; Ränik, Valeria. Ajast väljas; Kivi, Aita. Kalender-päevik Aita Kivi luuletustega; Maagemust, Maarika. Kaaludes kaldaid; Hiiussaar, Ann. Valgete uste taga; Kolkkanen, Imbi. Mina ja maailm; Mets, Neeme. Kesalill; Kolesnitshenko, Kaidi-Ly. Kaks silma; Kahro, Anne. Nälkjast!; Kabe, Aino. Tuulema mõtteriim. Raatma, Salme. Laululatern; Osila, Virve. Lootuse luiged; Isak, Asta. Valguse ja varjude vahel; Õunapuu, Meeli. Mööda teid ja radu

Efficacy of insecticides in fruit borer control and residues on sugar apple fruit

Directory of Open Access Journals (Sweden)

Alessandro da Silva Oliveira

Full Text Available ABSTRACT Bahia is the Brazilian state with the largest production of sugar apple fruits (Annona squamosa L., and fruit borer (Cerconota anonella, Sepp. 1830 is a key crop pest. Insecticides are the main strategy for pest control even though there are no pesticides registered for this crop. This study aimed to assess the efficacy of insecticides to control fruit borer and determine the levels of insecticide residues in sugar apple fruits aiming at requesting the extension of authorization to use insecticide products in this crop. The experiment was conducted in an eight-year-old irrigated orchard (2 × 4 m located in Anagé, Bahia, Brazil. The experimental design was a randomized block design with 10 treatments (three insecticides with three doses and a control with water and 5 replications. Each plot was composed of four plants but only the two central ones were assessed. Insecticides and doses (g a.i. 100 L−1 water were Bacillus thuringiensis: 0.8, 1.7, and 2.5; triflumuron: 2.4, 3.6, and 4.8; and imidacloprid: 4.0, 10.0, and 16.0. Nine sprayings were carried out at fortnightly intervals with a costal sprayer with constant pressure, JA-2 nozzle, and with jet directed to the fruits. Ten assessments were performed in order to observe fruit borer presence in 30 previously marked fruits per plot. Imidacloprid, at the highest studied dose, was the only effective treatment. Analyses of imidacloprid residues, at 21 and 30 days after the highest dose application, indicated levels higher than the maximum limit allowed. Insecticides under the conditions tested do not meet the norms for requesting the extension of authorization to use insecticides for citrus in sugar apple fruits.

Probiotic Lactobacilli Modulate Staphylococcus aureus-Induced Activation of Conventional and Unconventional T cells and NK cells

Directory of Open Access Journals (Sweden)

Maria A Johansson

2016-07-01

Full Text Available Lactobacilli are probiotic commensal bacteria and potent modulators of immunity. When present in the gut or supplemented as probiotics, they beneficially modulate ex vivo immune responsiveness. Further, factors derived from several lactobacilli strains act immune regulato-ry in vitro. In contrast, Staphylococcus aureus (S. aureus is known to induce excessive T cell activation. In this study we aimed to investigate S. aureus-induced activation of human muco-sal associated invariant T cells (MAIT cells, γδ T cells, NK cells, as well as of conventional CD4+ and CD8+ T cells in vitro. Further, we investigated if lactobacilli-derived factors could modulate their activation.PBMC were cultured with S. aureus 161:2 cell free supernatant (CFS, staphylococcal en-terotoxin A or CD3/CD28-beads alone or in combination with Lactobacillus rhamnosus (L. rhamnosus GG-CFS or Lactobacillus reuteri (L. reuteri DSM 17938-CFS, and activation of T and NK cells was evaluated. S. aureus-CFS induced IFN-γ and CD107a expression as well as proliferation. Co-stimulation with lactobacilli-CFS dampened lymphocyte activation in all cell types analysed. Pre-incubation with lactobacilli-CFS was enough to reduce subsequent activation and the ab-sence of APC or APC-derived IL-10 did not prevent lactobacilli-mediated dampening. Final-ly, lactate selectively dampened activation of unconventional T cells and NK cells. In summary, we show that molecules present in the lactobacilli-CFS are able to directly dampen in vitro activation of conventional and unconventional T cells and of NK cells. This study provides novel insights on the immune modulatory nature of probiotic lactobacilli and suggests a role for lactobacilli in modulation of induced T and NK cell activation.

Abatement of CO{sub 2} emissions in the European Union

Energy Technology Data Exchange (ETDEWEB)

Lesourne, J.; Keppler, J.H.; Jaureguy-Naudin, Maite; Smeers, Yves; Bouttes, Jean-Paul; Trochet, Jean-Michel; Dassa, Francois; Neuhoff, Karsten

2008-07-01

This first monograph of the Ifri program on European Governance and Geopolitics of Energy is devoted to the control of carbon dioxide emissions within the European Union. Since it is almost unanimously accepted that Greenhouse Gas emissions constitute the main cause of the observed increase of the world average temperature, the system implemented by the European Union to limit and decrease the CO{sub 2} emissions is a significant pillar of the EU energy policy, the two others being the acceptance by the Member States of long-term commitments (for instance on the future share of renewable energy sources in their energy balance sheet) and the establishment of an internal market for electricity and gas. Though simple in principle, the European Union Greenhouse Gas Emission Trading Scheme (EU ETS) is in fact rather complex, and only experts really understand its merits and its deficiencies. These deficiencies are real and will have to be corrected in the future for the system to be effective. At this moment, when the 2005-2007 trial phase of the EU ETS is ending, the monograph has the purpose to stimulate the discussion between experts and to enable all those interested in the topic to understand the issues and to take part in the public debates on the subject. The monograph contains five papers: - 'An Overview of the CO{sub 2} Emission Control System in the European Union' by Jacques Lesourne and Maite Jaureguy-Naudin. - 'Description and Assessment of EU CO{sub 2} Regulations' by Yves Smeers. - 'Assessment of EU CO{sub 2} Regulations' by Jean-Paul Bouttes, Jean-Michel Trochet and Francois Dassa. - 'Investment in Low Carbon Technologies, Policies for the Power Sector' by Karsten Neuhoff. - 'Lessons Learned from the 2005-2007 Trial Phase of the EU Emission Trading System' by Jan Horst Keppler

Abatement of CO2 emissions in the European Union

International Nuclear Information System (INIS)

Lesourne, J.; Keppler, J.H.; Jaureguy-Naudin, Maite; Smeers, Yves; Bouttes, Jean-Paul; Trochet, Jean-Michel; Dassa, Francois; Neuhoff, Karsten

2008-01-01

This first monograph of the Ifri program on European Governance and Geopolitics of Energy is devoted to the control of carbon dioxide emissions within the European Union. Since it is almost unanimously accepted that Greenhouse Gas emissions constitute the main cause of the observed increase of the world average temperature, the system implemented by the European Union to limit and decrease the CO 2 emissions is a significant pillar of the EU energy policy, the two others being the acceptance by the Member States of long-term commitments (for instance on the future share of renewable energy sources in their energy balance sheet) and the establishment of an internal market for electricity and gas. Though simple in principle, the European Union Greenhouse Gas Emission Trading Scheme (EU ETS) is in fact rather complex, and only experts really understand its merits and its deficiencies. These deficiencies are real and will have to be corrected in the future for the system to be effective. At this moment, when the 2005-2007 trial phase of the EU ETS is ending, the monograph has the purpose to stimulate the discussion between experts and to enable all those interested in the topic to understand the issues and to take part in the public debates on the subject. The monograph contains five papers: - 'An Overview of the CO 2 Emission Control System in the European Union' by Jacques Lesourne and Maite Jaureguy-Naudin. - 'Description and Assessment of EU CO 2 Regulations' by Yves Smeers. - 'Assessment of EU CO 2 Regulations' by Jean-Paul Bouttes, Jean-Michel Trochet and Francois Dassa. - 'Investment in Low Carbon Technologies, Policies for the Power Sector' by Karsten Neuhoff. - 'Lessons Learned from the 2005-2007 Trial Phase of the EU Emission Trading System' by Jan Horst Keppler

Omandi sundvõõrandamise instituut Eesti Vabariigi ja Saksamaa Liitvabariigi õiguskordades : (võrdlev käsitlus) : [bakalaureusetöö] / Mait Laaring ; Tartu Ülikool, õigusteaduskond ; juhendaja: Kalle Merusk

Index Scriptorium Estoniae

Laaring, Mait, 1979-

2003-01-01

Sundvõõrandamise instituudi ajaloolisest arengust, mõistest, omandigarantii olemusest, sundvõõrandamisest ja sotsialiseerimisest (natsionaliseerimisest), sundvõõrandamise õiguspärasuse eeldustest, tagajärgedest, kohtulikust vaidlustamisest

The Estonian Foundation – What is Missing for It to Be A Well-Designed Wealth-Management Vehicle for Local and Foreign High-Net-Worth Individuals? / Katrin Sepp , Urmas Kaarlep

Index Scriptorium Estoniae

Sepp, Katrin

2016-01-01

Erahuvides sihtasutustest, neile kohalduvast seadusest Eestis ja kohalduva seaduse parendamise ettepanekutest teiste riikide näitel. Erahuvides sihtasutuste kasutamise eesmärkidest ja sellega seonduvatest probleemidest Eesti seadusandluses

Lasteaia ja lõbumaja vahel : eesti proosa 2008 / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2009-01-01

Ülevaade 2008. aasta eesti proosast. Pikemalt käsitletakse järgmisi autoreid ja nende teoseid: Mihkel Raud "Musta pori näkku", Olev Remsu "Musketäride muundumised", Rein Põder "Juba olnud", Juhan Nurme "Ligimene", Jaan Tangsoo "Méduse'i parv", Esta Aksli "Tare poole tõttaja", Mari Saat "Lasnamäe lunastaja", Peeter Morgen "Sõnum", Mait Raun "Dr. Mööbi seiklused Inglismaal", Andrei Hvostov "Võõrad lood" ja "Projektijuht Posse", Chaneldior "Kontrolli alt väljas", Vahur Afanasjev "Kosmos", Egon Ilisson "Isased", Jaak Leer "Kaks kabanossi ja Maaja", Kärt Hellerma "Sinine missa", Elo Viiding "Püha Maama", Toomas Raudam "Miks ma ei taha olla kirjanik?", Mart Kivastik "Kurb raamat", Jüri Tuulik "Räim, pisike kena kala", Tarmo Teder "12 jõulujuttu", Dagmar Lamp (koostaja) "Tule, ma jutustan sulle loo", Eia Uus "Kahe näoga jumal", Barthol Lo Mejor "Popdada 2007-2008", Anti Saar "Nemad kaks", Ketlin Priilinn "Liiseli võti" ja "Vaim", Aita Kivi "Lähedal", Marje Ernits "Hoia mu kätt", Kati Murutar "Naisena sündinud : kakskümmend aastat hiljem", Tuule Lind "Pööratud tuul", Siiri Laidla "Lihtne lugu, ehk, Senta suvepuhkus", Kätlin Padesaar "Veel üks paradiis", Aimée Beekman "Proovielu", Lehte Hainslau "Kolmkõla, ehk, 3 kõla", Ira Lember "Ööviiulid", Tamur Kusnets "Hundipäikese aeg : metsiku jahi algus", Kaupo Pähkel "Ehatähe rüütel", Arvo Valton "Ülemiste vanake", Tiit Aleksejev "Palveränd", Ants Eret "Afgaanide vang", Mario Merirand "Afganistani päevik", Leo Kunnas "Gort Ashryn", Rein Raud "Vend", Peeter Sauter "Beibi bluu", Marion Andra "Pimend", Kristjan Sander "13 talvist hetke", Helga Nõu "Peaaegu geenius, ehk, Schrödingeri kassi otsimas", Tiit Sepa "Eefa hüüdnimega Siug", Kaarel ja Klaara Kivi "Varandus seinal", Merike Jürjo "Mälestusteta maja", Rein Vahisalu "Viies kabinet", Aarne Biin "Mees otsib naist", Erik Tohvri "Ümberasujad" ja "Sulasest sai peremees", Arnold Laugus "Elav maa", Jüri v. Grauberg "Selguse poole", J�

Lasteaia ja lõbumaja vahel : Eesti proosa 2008 / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2012-01-01

Ülevaade 2008. aasta eesti proosast. Pikemalt käsitletakse järgmisi autoreid ja nende teoseid: Mihkel Raud "Musta pori näkku", Olev Remsu "Musketäride muundumised", Rein Põder "Juba olnud", Juhan Nurme "Ligimene", Jaan Tangsoo "Méduse'i parv", Esta Aksli "Tare poole tõttaja", Mari Saat "Lasnamäe lunastaja", Peeter Morgen "Sõnum", Mait Raun "Dr. Mööbi seiklused Inglismaal", Andrei Hvostov "Võõrad lood" ja "Projektijuht Posse", Chaneldior "Kontrolli alt väljas", Vahur Afanasjev "Kosmos", Egon Ilisson "Isased", Jaak Leer "Kaks kabanossi ja Maaja", Kärt Hellerma "Sinine missa", Elo Viiding "Püha Maama", Toomas Raudam "Miks ma ei taha olla kirjanik?", Mart Kivastik "Kurb raamat", Jüri Tuulik "Räim, pisike kena kala", Tarmo Teder "12 jõulujuttu", Dagmar Lamp (koostaja) "Tule, ma jutustan sulle loo", Eia Uus "Kahe näoga jumal", Barthol Lo Mejor "Popdada 2007-2008", Anti Saar "Nemad kaks", Ketlin Priilinn "Liiseli võti" ja "Vaim", Aita Kivi "Lähedal", Marje Ernits "Hoia mu kätt", Kati Murutar "Naisena sündinud : kakskümmend aastat hiljem", Tuule Lind "Pööratud tuul", Siiri Laidla "Lihtne lugu, ehk, Senta suvepuhkus", Kätlin Padesaar "Veel üks paradiis", Aimée Beekman "Proovielu", Lehte Hainslau "Kolmkõla, ehk, 3 kõla", Ira Lember "Ööviiulid", Tamur Kusnets "Hundipäikese aeg : metsiku jahi algus", Kaupo Pähkel "Ehatähe rüütel", Arvo Valton "Ülemiste vanake", Tiit Aleksejev "Palveränd", Ants Eret "Afgaanide vang", Mario Merirand "Afganistani päevik", Leo Kunnas "Gort Ashryn", Rein Raud "Vend", Peeter Sauter "Beibi bluu", Marion Andra "Pimend", Kristjan Sander "13 talvist hetke", Helga Nõu "Peaaegu geenius, ehk, Schrödingeri kassi otsimas", Tiit Sepa "Eefa hüüdnimega Siug", Kaarel ja Klaara Kivi "Varandus seinal", Merike Jürjo "Mälestusteta maja", Rein Vahisalu "Viies kabinet", Aarne Biin "Mees otsib naist", Erik Tohvri "Ümberasujad" ja "Sulasest sai peremees", Arnold Laugus "Elav maa", Jüri v. Grauberg "Selguse poole", J�

Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Animal Model of Gulf War Illness

Science.gov (United States)

Shetty, Geetha A.; Hattiangady, Bharathi; Upadhya, Dinesh; Bates, Adrian; Attaluri, Sahithi; Shuai, Bing; Kodali, Maheedhar; Shetty, Ashok K.

2017-01-01

Memory and mood dysfunction are the key symptoms of Gulf war illness (GWI), a lingering multi-symptom ailment afflicting >200,000 veterans who served in the Persian Gulf War-1. Research probing the source of the disease has demonstrated that concomitant exposures to anti-nerve gas agent pyridostigmine bromide (PB), pesticides, and war-related stress are among the chief causes of GWI. Indeed, exposures to GWI-related chemicals (GWIR-Cs) and mild stress in animal models cause memory and mood impairments alongside reduced neurogenesis and chronic low-level inflammation in the hippocampus. In the current study, we examined whether exposure to GWIR-Cs and stress causes chronic changes in the expression of genes related to increased oxidative stress, mitochondrial dysfunction, and inflammation in the hippocampus. We also investigated whether GWI is linked with chronically increased activation of Nrf2 (a master regulator of antioxidant response) in the hippocampus, and inflammation and enhanced oxidative stress at the systemic level. Adult male rats were exposed daily to low-doses of PB and pesticides (DEET and permethrin), in combination with 5 min of restraint stress for 4 weeks. Analysis of the hippocampus performed 6 months after the exposure revealed increased expression of many genes related to oxidative stress response and/or antioxidant activity (Hmox1, Sepp1, and Srxn1), reactive oxygen species metabolism (Fmo2, Sod2, and Ucp2) and oxygen transport (Ift172 and Slc38a1). Furthermore, multiple genes relevant to mitochondrial respiration (Atp6a1, Cox6a1, Cox7a2L, Ndufs7, Ndufv1, Lhpp, Slc25a10, and Ucp1) and neuroinflammation (Nfkb1, Bcl6, Csf2, IL6, Mapk1, Mapk3, Ngf, N-pac, and Prkaca) were up-regulated, alongside 73–88% reduction in the expression of anti-inflammatory genes IL4 and IL10, and nuclear translocation and increased expression of Nrf2 protein. These hippocampal changes were associated with elevated levels of pro-inflammatory cytokines and chemokines

Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Animal Model of Gulf War Illness.

Science.gov (United States)

Shetty, Geetha A; Hattiangady, Bharathi; Upadhya, Dinesh; Bates, Adrian; Attaluri, Sahithi; Shuai, Bing; Kodali, Maheedhar; Shetty, Ashok K

2017-01-01

Memory and mood dysfunction are the key symptoms of Gulf war illness (GWI), a lingering multi-symptom ailment afflicting >200,000 veterans who served in the Persian Gulf War-1. Research probing the source of the disease has demonstrated that concomitant exposures to anti-nerve gas agent pyridostigmine bromide (PB), pesticides, and war-related stress are among the chief causes of GWI. Indeed, exposures to GWI-related chemicals (GWIR-Cs) and mild stress in animal models cause memory and mood impairments alongside reduced neurogenesis and chronic low-level inflammation in the hippocampus. In the current study, we examined whether exposure to GWIR-Cs and stress causes chronic changes in the expression of genes related to increased oxidative stress, mitochondrial dysfunction, and inflammation in the hippocampus. We also investigated whether GWI is linked with chronically increased activation of Nrf2 (a master regulator of antioxidant response) in the hippocampus, and inflammation and enhanced oxidative stress at the systemic level. Adult male rats were exposed daily to low-doses of PB and pesticides (DEET and permethrin), in combination with 5 min of restraint stress for 4 weeks. Analysis of the hippocampus performed 6 months after the exposure revealed increased expression of many genes related to oxidative stress response and/or antioxidant activity ( Hmox1, Sepp1 , and Srxn1 ), reactive oxygen species metabolism ( Fmo2, Sod2 , and Ucp2 ) and oxygen transport ( Ift172 and Slc38a1 ). Furthermore, multiple genes relevant to mitochondrial respiration ( Atp6a1, Cox6a1, Cox7a2L, Ndufs7, Ndufv1, Lhpp, Slc25a10 , and Ucp1 ) and neuroinflammation ( Nfkb1, Bcl6, Csf2, IL6, Mapk1, Mapk3, Ngf, N-pac , and Prkaca ) were up-regulated, alongside 73-88% reduction in the expression of anti-inflammatory genes IL4 and IL10 , and nuclear translocation and increased expression of Nrf2 protein. These hippocampal changes were associated with elevated levels of pro-inflammatory cytokines

Estudo histomorfométrico dos cardiomiócitos do ventrículo esquerdo das ratas albinas durante a prenhez Histomorphometrical study of cardiomyocytes of the left ventricular of albino rats during pregnancy

Directory of Open Access Journals (Sweden)

A.W. Liberatori Filho

1999-07-01

Full Text Available OBJETIVO. No presente estudo propusemo-nos a avaliar, por meio da microscopia de luz, os aspectos morfológicos e morfométricos dos cardiomiócitos do ventrículo esquerdo de ratas albinas durante a prenhez. MÉTODOS. Acasalamos doze ratas virgens que foram dividas ao acaso em quatro grupos, de acordo com a idade gestacional. Os animais correspondentes a cada grupo foram sacrificados ao 1o(G-A, 7o(G-B, 14o(G-C e 21o(G-D dias de prenhez, sendo coletados fragmentos do terço médio do ventrículo esquerdo, os quais após processamento apropriado, permitiram observação adequada à microscopia de luz. A cariometria foi realizada mensurando-se os diâmetros maiores e menores dos cardiomiócitos com o auxílio de um tambor rotativo modelo K 8 X adaptado a um microscópio de luz. RESULTADOS. O estudo em nível da microscopia de luz praticamente não mostrou alterações com o decorrer da prenhez. No entanto, a morfometria revelou que os volumes dos cardiomiócitos estão aumentados no 14o dia da prenhez, mostrando-se estatisticamente significante quando comparado aos demais grupos estudados. Assim, nossos resultados demonstraram haver hipertrofia ventricular esquerda durante a gestação. CONCLUSÃO. Durante a gestação há um processo dinâmico reversível de remodelação ventricular em conseqüência das alterações adaptativas gravídicas.PURPOSE. In the present study we evaluated, by light microscopy, and throughout morphometry, whether hypertrophy of cardiac striated muscular fibers of left ventricular occur in albino rat, during pregnancy. METHODS. After maiting, 12 nuliparous rats were divided into four groups with three animals for each group. The female rats corresponding to each group were killed at 1st, 7th, 14th and 21st days of pregnancy. RESULTS. Observation, on light microscopy (H.E had at one view, did not display any alterations during pregnancy. However, the morphometry revealed that nuclei of cardiomyocytes are augmented in

Prevalence of conventional risk factors and lipid profiles in patients with acute coronary syndrome and significant coronary disease

Directory of Open Access Journals (Sweden)

González-Pacheco H

2014-10-01

Full Text Available Héctor González-Pacheco,1 Jesús Vargas-Barrón,2 Maite Vallejo,2 Yigal Piña-Reyna,3 Alfredo Altamirano-Castillo,1 Pedro Sánchez-Tapia,1 Carlos Martínez-Sánchez1 1Coronary Care Unit, National Institute of Cardiology in Mexico City, Mexico City, Mexico; 2Department of Clinical Research, National Institute of Cardiology in Mexico City, Mexico City, Mexico; 3Catheterization Laboratory, National Institute of Cardiology in Mexico City, Mexico City, Mexico Background: Among patients with coronary artery disease (CAD, 80%–90% present at least one conventional risk factor. On the other hand, lipid profile modification after a cardiovascular event related to acute coronary syndrome (ACS has been recognized. The prevalence of conventional risk factors and the lipid profile at the time of admission in patients with ACS and significant CAD (stenosis ≥50% determined through coronary angiography is not well described. Methods: We studied 3,447 patients with a diagnosis of ACS and significant CAD with stenosis ≥50%, as shown on angiography. We recorded the presence of conventional risk factors, including smoking, hypertension, dyslipidemia, and diabetes. In addition, we analyzed the lipid profiles within the first 24 hours of admission. We analyzed the studied population and compared findings according to sex.Results: Most patients (81.7% were male. ST-elevation myocardial infarction was present in 51.3% of patients, and non-ST-elevation acute coronary syndrome was present in 48.7%. The most frequent risk factor was smoking, which was present in 68% of patients, followed by hypertension (57.8%, dyslipidemia (47.5%, and diabetes (37.7%. In women, the most frequent risk factors were hypertension, diabetes, and dyslipidemia, whereas in men, smoking was the most frequent. We identified at least one risk factor in 95.7% of all patients, two or three risk factors in 62%, and four risk factors in 8.6% of patients. The lipid profile analysis revealed that

Energy in India's Future: Insights

International Nuclear Information System (INIS)

Lesourne, J.; Ramsay, W.C.; Jaureguy-Naudin, Maite; Boillot, Jean-Joseph; Autheman, Nicolas; Ruet, Joel; Siddiqui, Zakaria; Zaleski, C. Pierre; Cruciani, Michel

2009-01-01

In the decades following India's independence from British rule in 1947, the West's image of India was summarized in three simple cliches: the world's largest democracy, an impoverished continent, and economic growth hampered by a fussy bureaucracy and the caste system, all in a context of a particular religion. These cliches are perhaps one of the reasons that the success of India's green revolution was recognized so late, a revolution that allowed the country to develop its agricultural sector and to feed its population. Since the 1990's, the easing of planning constraints have liberated the Indian economy and allowed it to embark on a more significant path of growth. New cliches have begun to replace the old: India will become a second China and, lagging by 10 to 20 years, will follow the same trajectory, with its development marked more by services and the use of renewable energy. However, these trends will not prevent primary energy demand from exploding. On the contrary, India faces difficult choices on how it increases clean, secure, affordable energy to all its citizens. Many of the choices are the same as found elsewhere, but on a scale matched only by China. The IFRI European Governance and Geopolitics of Energy Project intends this study to deepen public understanding of the magnitude of India's challenges. Various aspects of the serious energy problems are studied throughout this monograph. The authors have written freely on these matters without attempting to reconcile their different viewpoints. The first chapter, by Maite Jaureguy-Naudin and Jacques Lesourne, presents an overview of India's present and future energy system. The authors follow a prudent but realistic view of India's future. The second chapter, by Jean-Joseph Boillot, a French expert on India who has published several books and articles on this subject, and Nicolas Autheman, research fellow, describes in greater detail the specifics of India's economy and the actors who are now present

Energy in India's Future: Insights

Energy Technology Data Exchange (ETDEWEB)

Lesourne, J.; Ramsay, W.C.; Jaureguy-Naudin, Maite; Boillot, Jean-Joseph; Autheman, Nicolas; Ruet, Joel; Siddiqui, Zakaria; Zaleski, C. Pierre; Cruciani, Michel

2009-07-01

In the decades following India's independence from British rule in 1947, the West's image of India was summarized in three simple cliches: the world's largest democracy, an impoverished continent, and economic growth hampered by a fussy bureaucracy and the caste system, all in a context of a particular religion. These cliches are perhaps one of the reasons that the success of India's green revolution was recognized so late, a revolution that allowed the country to develop its agricultural sector and to feed its population. Since the 1990's, the easing of planning constraints have liberated the Indian economy and allowed it to embark on a more significant path of growth. New cliches have begun to replace the old: India will become a second China and, lagging by 10 to 20 years, will follow the same trajectory, with its development marked more by services and the use of renewable energy. However, these trends will not prevent primary energy demand from exploding. On the contrary, India faces difficult choices on how it increases clean, secure, affordable energy to all its citizens. Many of the choices are the same as found elsewhere, but on a scale matched only by China. The IFRI European Governance and Geopolitics of Energy Project intends this study to deepen public understanding of the magnitude of India's challenges. Various aspects of the serious energy problems are studied throughout this monograph. The authors have written freely on these matters without attempting to reconcile their different viewpoints. The first chapter, by Maite Jaureguy-Naudin and Jacques Lesourne, presents an overview of India's present and future energy system. The authors follow a prudent but realistic view of India's future. The second chapter, by Jean-Joseph Boillot, a French expert on India who has published several books and articles on this subject, and Nicolas Autheman, research fellow, describes in greater detail the specifics of India

Pyrrhopyginae: gêneros novos e revalidados (Lepidoptera, Hesperiidae Pyrrhopyginae: new and revalidated genera (Lepidoptera, Hespe-riidae

Directory of Open Access Journals (Sweden)

Olaf H.H. Mielke

2002-03-01

Full Text Available The following new genera with their type-species are described: Oxynetrini: Cyclopyge gen. n. - type-species: Pyrrhopyge roscius Hopffer, 1874; Pyrrhopygini: Arnysoria gen. n. - type species: Pyrrhopyga [sic] galgala Hewitson, 1866, Chalypyge gen. n. - type species: Pyrrhopyga [sic] chalybea Scudder, 1872, Creonpyge gen. n. - type species: Pyrrhopyga [sic] creon H. Druce, 1874, Cyanopyge gen. n. - type species: Pyrrhopyge sangaris Skinner, 1921, Gunayan gen. n. - type species: Pyrrhopyga [sic] rhacia Hewitson, 1875, Jonaspyge gen. n. - type species: Pyrrhopyga [sic] Jonas C. Felder & R. Felder, 1859, Melanopyge gen. n. - type species: Pyrrhopyga [sic] maculosa Hewitson, 1866, Mimardaris gen. n. - type species: Pyrrhopyga [sic] sela Hewitson, 1866, Mysarbia gen. n. - type species: Pyrrhopyge sejanus Hopffer, 1874, Ochropyge gen. n. - type species: Pyrrhopyge ruficauda Hayward, 1932. Apyrrothrix Lindsey, 1921 and Yanguna Watson, 1893 are revalidated. The following are revalidated combinations: Apyrrothrix araxes (Hewitson, 1867, Apyrrothrix arizonae (Godman & Salvin, 1893, Yanguna cometes cometes (Cramer, 1770, Yanguna cometes cometides Mabille & Boullet, 1908, Yanguna cometes staudingeri (Plštz, 1879, Yanguna cosyra (H. Druce, 1875, Yanguna spatlosa spatlosa (Hewitson, 1871, Yanguna spatlosa aspllos Mabille & Boullet, 1908, Yanguna spatlosa mabillei H.H. Druce, 1909, Yanguna tetricus Bell, 1931, Yanguna thelersa (Hewitson, 1866, The following are new combinations: Cyclopyge roscius roscius (Hopffer, 1874, Cyclopyge roscius flavomaculata (Bell, 1937, Cyclopyge roscius iphimedia (Plštz, 1886, Yanguna erebus (Plštz, 1879, Gunayan rhacia (Hewitson, 1875, Gunayan rubrlcollts (Sepp, [1841], Gunayan timaeus (Bell, 1931, Chalypyge chalybea chalybea (Scudder, 1872, Chalypyge chalybea chlorts (Evans, 1951, Chalypyge zereda zereda (Hewitson, 1866, Chalypyge zereda hygieia (C. Felder & R. Felder, 1867, Chalypyge zereda insana (Staudinger, 1876, Chalypyge

Väike teatmik (Tartu paranoiakriitilise risoomi kohta / A Small Guide to the (Tartu Paranoiac-Critical Rhizome

Directory of Open Access Journals (Sweden)

Aare Pilv

2013-06-01

Full Text Available The paper gives an overview of a network of authors who have been active since the end of the 20th century, mainly (but not only in Tartu. They can be characterized as having an experimental attitude and maintaining distance from the literary mainstream, but at the same time they do not try to be consciously polemical or novatory, because partly they repeat the techniques of the 20th century avant-garde and, what is maybe more important, they sidestep the dialectics of innovating or altering the literary canon. The network is not strictly organized; it is rather a rhizome that has some denser nodes (literary journals and mailing lists. There have been different attempts to name the phenomenon: Tartu avant-garde, microcosmic literature, cognitive realism, Y-literature, "eksp" and so on. I have chosen "paranoiac-critique" as the term that best captures the common characteristics of these authors and their artistic practices (some of the authors are active not only as text writers, but also as conceptual artists.The paper then gives a list, with commentary, of the most important groups and individuals of that movement. In the role of "predecessors" are the group 14NÜ (Paavo Matsin, Mait Laas, Marianne Ravi et al., which also experimented with the format of the book, and a company in Tartu that developed a specific actionist stylistics called "mugiv" (Marko Kompus, Mehis Heinsaar, Martiini, Kaspar et al.. The sovereign figure in the experimental network is Valdur Mikita, who has also academically researched the problems of creativity; he is also a theoretician and metapoet. An important institution for the network has been the literary journal Vihik (initiator Berk Vaher; the later editor of the journal Jaak Tomberg has also participated in activities of the Tartu Theatre Laboratory (managed by Andreas W, which has experimented with "technological theatre". In the middle of the first decade of the 21st century the network has gathered around the

The impact of large-scale circulation patterns on summer crop yields in IP

Science.gov (United States)

Capa Morocho, Mirian; Rodríguez Fonseca, Belén; Ruiz Ramos, Margarita

2014-05-01

companies) sectors, to take advantage of favorable conditions or reduce the effect of adverse conditions. Acknowledgements Research by M. Capa-Morocho has been partly supported by a PICATA predoctoral fellowship of the Moncloa Campus of International Excellence (UCM-UPM) and MULCLIVAR project (CGL2012-38923-C02-02) References Aasa, A., Jaagus, J., Ahas, R. and Sepp, M. 2004. The influence of atmospheric circulation on plant phenological phases in central and eastern Europe. International Journal of Climatology 24, 1551-1564. Gabaldón, C. et al. 2013. Evaluation of local strategies to climate change of maize crop in Andalusia for the first half of 21st century. European Geosciences Union - General Assembly2013 Vol. 15 (Vienna - Austria, 2013). Garnett, E. R. and Khandekar, M. L. 1992. The impact of large-scale atmospheric circulations and anomalies on Indian monsoon droughts and floods and on world grain yields-a statistical analysis. Agricultural and Forest Meteorology 61, 113-128. Jones, C. and Kiniry, J. 1986. CERES-Maize: A Simulation Model of Maize Growth and Development. Texas A&M University Press, 194. Rozas, V. and Garcia-Gonzalez, I. 2012. Non-stationary influence of El Nino-Southern Oscillation and winter temperature on oak latewood growth in NW Iberian Peninsula. Int J Biometeorol 56, 787-800.

Measuring Variance in Subnational Regimes: Results from an Expert-Based Operationalization of Democracy in the Argentine Provinces Midiendo la variación de los regímenes subnacionales: Resultados de una operacionalización basada en expertos de la democracia en las provincias argentinas

Directory of Open Access Journals (Sweden)

Carlos Gervasoni

2010-01-01

Full Text Available This paper presents an expert-based operationalization strategy to measure the degree of democracy in the Argentine provinces. Starting with a mainstream and “thick” definition of regime type, I assess each of its aspects using a subjective or perception-based approach that taps the knowledge of experts on the politics of each province. I present and justify the methodological design of the resulting Survey of Experts on Provincial Politics (SEPP and conduct a preliminary analysis of its results. Some aspects of the provincial regimes appear to be clearly democratic, while others are mixed or even leaning towards authoritarianism. Moreover, some show little interprovincial variance, while others vary considerably from province to province. An analysis of the central tendency and dispersion of the survey items allows for a general description of the Argentine provincial regimes. Inclusion is the most democratic dimension, while the effectiveness of institutional constraints on the power of the Executive is the most deficient. Electoral contestation is generally free of traditional forms of fraud, but incumbents often command far more campaign resources and media attention than do their challengers. Physical repression is rare, but opponents in some provinces face subtler forms of punishment. While the survey does not uncover any clear cases of subnational authoritarianism, stricto sensu, provincial regimes do vary significantly from basically democratic to clearly hybrid. Este artículo presenta una estrategia de operacionalización basada en expertos para medir el grado de democracia en las provincias argentinas. Partiendo de una definición convencional y “densa” del tipo de régimen, se evalúan cada uno de sus aspectos usando un enfoque subjetivo o basado en percepciones, que explota el conocimiento de expertos en la política de cada provincia. Se presenta y justifica el diseño metodológico de la resultante Encuesta de Expertos en

PREFACE: The Eighth Liquid Matter Conference The Eighth Liquid Matter Conference

Science.gov (United States)

Dellago, Christoph; Kahl, Gerhard; Likos, Christos N.

2012-07-01

interface tension of flat and curved interfaces from Monte Carlo simulationsA Tröster and K Binder Phase diagrams of particles with dissimilar patches: X-junctions and Y-junctionsJ M Tavares and P I C Teixeira The unbearable heaviness of colloids: facts, surprises, and puzzles in sedimentationRoberto Piazza, Stefano Buzzaccaro and Eleonora Secchi Exploring water and other liquids at negative pressureFrédéric Caupin, Arnaud Arvengas, Kristina Davitt, Mouna El Mekki Azouzi, Kirill I Shmulovich, Claire Ramboz, David A Sessoms and Abraham D Stroock The configurational space of colloidal patchy polymers with heterogeneous sequencesIvan Coluzza and Christoph Dellago Repeated sorption of water in SBA-15 investigated by means of in situ small-angle x-ray scatteringM Erko, D Wallacher, G H Findenegg and O Paris Transition of the hydration state of a surfactant accompanying structural transitions of self-assembled aggregatesM Hishida and K Tanaka The effects of topology on the structural, dynamic and mechanical properties of network-forming materialsMark Wilson Surface tension of an electrolyte-air interface: a Monte Carlo studyAlexandre Diehl, Alexandre P dos Santos and Yan Levin Water and other tetrahedral liquids: order, anomalies and solvationB Shadrack Jabes, Divya Nayar, Debdas Dhabal, Valeria Molinero and Charusita Chakravarty Diffusion coefficient and shear viscosity of rigid water modelsSami Tazi, Alexandru Boţan, Mathieu Salanne, Virginie Marry, Pierre Turq and Benjamin Rotenberg Phase behaviour of colloidal assemblies on 2D corrugated substratesSamir El Shawish, Emmanuel Trizac and Jure Dobnikar Structural properties of dendrimer-colloid mixturesDominic A Lenz, Ronald Blaak and Christos N Likos Fluid-fluid demixing of off-critical colloid-polymer systems confined between parallel platesE A G Jamie, R P A Dullens and D G A L Aarts Simulations of nematic homopolymer melts using particle-based models with interactions expressed through collective variablesKostas Ch

PREFACE: Loops 11: Non-Perturbative / Background Independent Quantum Gravity

Science.gov (United States)

Mena Marugán, Guillermo A.; Barbero G, J. Fernando; Garay, Luis J.; Villaseñor, Eduardo J. S.; Olmedo, Javier

2012-05-01

only was it a showroom for the research currently being carried out by many groups throughout the world, but there was also a permanent look towards the future. During these days, the CSIC Campus witnessed many scientific conversations triggered by the interaction amongst the people and groups that participated in LOOPS'11 Madrid and which, in many cases, will crystallise into new results and advances in the field. The conference would not have been possible without the generous help of a number of national and international institutions. The organizers would like to acknowledge the financial support provided by the Spanish Ministry of Science and Innovation (Ministerio de Ciencia e Innovación), the Spanish Research Council, CSIC (Consejo Superior de Investigaciones Cientĺficas), The BBVA Foundation (Fundación BBVA), The CONSOLIDER-CPAN project, the Spanish Society for Gravitation and Relativity (SEGRE), The Universidad Carlos III of Madrid (UC3M), and the European Science Foundation (ESF). The ESF, through the Quantum Gravity and Quantum Geometry network, provided full support for a number of young participants that have contributed to these proceedings: Dario Benedetti (Albert Einstein Institute, Potsdam, Germany), Norbert Bodendorfer (Institute for Theoretical Physics III, FAU Erlangen Nürnberg, Germany), Mariam Bouhmadi López (CENTRA, Centro Multidisciplinar de Astrofĺsica, Lisbon), Timothy Budd (Institute for Theoretical Physics, Utrecht University, The Netherlands), Miguel Campiglia (Institute for Gravitation and the Cosmos, Penn State University, USA), Gianluca Delfino (School of Mathematical Sciences, University of Nottingham, UK), Maite Dupuis (Institute for Theoretical Physics III, FAU Erlangen Nürnberg, Germany), Michał Dziendzikowski (Institute of Theoretical Physics, Warsaw University, Poland), Muxin Han (Centre de Physique Théorique de Luminy, Marseille, France), Philipp Höhn (Institute for Theoretical Physics, Utrecht University, The

Evaluación del crecimiento y determinación de índices de cosecha

Directory of Open Access Journals (Sweden)

Méndez Mario A.

2004-06-01

Full Text Available

El género

Efecto del riego y de la fertilización sobre la incidencia del rajado

Directory of Open Access Journals (Sweden)

Gordillo Olga Patricia

2004-06-01

ón técnica, técnica con calcio adicional y sin

fertilización. En este mismo muestreo, cuando aumentó

la lámina de riego aplicada, tanto en la fertilización técnica

como en la técnica con baja dosis de potasio, también

se incrementó el porcentaje de rajado en los frutos

de uchuva. El porcentaje de rajado promedio para todos

los tratamientos se presentó en relación directa con el

estado de maduración del fruto y el mayor porcentaje se

Laps(epõlv 19. sajandi teise poole Eestis omaelulooliste tekstide näitel. Child(hood in 19th Century Estonia: a Study of Autobiographical Texts

Directory of Open Access Journals (Sweden)

Ave Mattheus

2012-04-01

Full Text Available In this article I discuss autobiographical texts which focus on children and childhood in late 19th century Estonia. Childhood memories as well as other autobiographical material became popular in Estonia in the 1920s-1930s, when most of the studied works--the memoirs by Anna Haava, Mait Metsanurk, Jaan Lattik, Jaan Vahtra, Friedebert Tuglas, August Kitzberg and Marta Sillaots--were written. Some texts come from the 19th century (e.g. Lilli Suburg’s autobiographical works or early 20th century (e.g. manuscripts by Hans Leoke, and Johannes Kõrv. Childhood as described in these autobiographical texts covers a period of circa 1850-1900, and the majority of the authors come from the families of South-Estonian peasants or manorial servants. In addition to being written in Estonian and having the same theme, they were all also written by authors of fiction for children or by people who had close contact with children, such as schoolteachers. The article offers a novel approach in the Estonian context by presenting a typology of childhood stories and looking at childhood recollections as an important part of childhood studies. The researchers of childhood investigate how society understands and values children and childhood, what children’s everyday life is like, what possibilities there are for development and if there exists a specific children’s culture in society (such as clothing, food, language, leisure activities, or independent creative work. Childhood studies as a separate discipline does not exist in Estonia, although some important works have been published by educational scholars and art historians. The autobiographical texts under discussion show that in the late 19th century, the majority of Estonian children lived in the countryside in patriarchal families, and childhood was short because children had to help their parents with farmwork quite early, at the age of six. The boundary of childhood was around the age of 10-11, when

SMART-1 leaves Earth on a long journey to the Moon

Science.gov (United States)

2003-09-01

The European Space Agency’s SMART-1 was one of three payloads on Ariane Flight 162. The generic Ariane-5 lifted off from the Guiana Space Centre, Europe’s spaceport at Kourou, French Guiana, at 2014 hrs local time (2314 hrs GMT) on 27 September (01:14 Central European Summer time on 28 September). 42 minutes after launch, SMART-1 as last of the three satellites had been successfully released into a geostationary transfer orbit (654 x 35 885 km, inclined at 7 degrees to the Equator). While the other two satellites are due to manoeuvre towards geostationary orbit, the 367 kg SMART-1 will begin a much longer journey to a target ten times more distant than the geostationary orbit: the Moon. “Europe can be proud”, said ESA Director General Jean-Jacques Dordain, after witnessing the launch from ESA’s ESOC space operations centre in Darmstadt, Germany, “we have set course for the Moon again. And this is only the beginning: we are preparing to reach much further”. The spacecraft has deployed its solar arrays and is currently undergoing initial checkout of its systems under control from ESA/ESOC. This checkout will continue until 4 October and will include with the initial firing of SMART-1’s innovative ion engine. By ion drive to the Moon “Science and technology go hand in hand in this exciting mission to the Moon. The Earth and Moon have over 4 thousand million years of shared history, so knowing the Moon better will help scientists in Europe and all over the world to better understand our planet and will give them valuable new hints on how to better safeguard it” said ESA Director of Science David Southwood, following the launch from Kourou. As the first mission in the new series of Small Missions for Advanced Research in Technology, SMART-1 is mainly designed to demonstrate innovative and key technologies for future deep space science missions. The first technology to be demonstrated on SMART-1 will be Solar Electric Primary Propulsion (SEPP), a

Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Epidemiology and Networks"

Directory of Open Access Journals (Sweden)

--- Various Authors

2017-10-01

PREMATURITY • Z. Owsiańska, G. Matusiak, K. Mielnik, T. Szczapa, J. GadzinowskiABS 27. RIGHT PLACE – RIGHT TIME? PLACE OF BIRTH AND TRANSFERS OF EXTREME PRE­TERM NEONATES WITHIN TWO ADJACENT NEO­NATAL OPERATIONAL DELIVERY NETWORKS • D. Vieten, M. Sutcliffe, V. Rasiah, A. PhilpottABS 28. MORBIDITY, MORTALITY AND 2-YEAR OUT­COME OF BABIES BORN WITH WEIGHT ≤ 500 G OVER 11 YEARS IN A TERTIARY NEONATAL UNIT • M. Noureldein, A. Olariu, J. EgyepongABS 29. PHENOTYPIC SPECTRUM OF GOLDENHAR SYNDROME: A DESCRIPTIVE STUDY • N. Kasdallah, M.T. Lamouchi, M. Sallemi, W. Barbaria, KasraouABS 30. EPIDEMIOLOGY OF ESBL-PRODUCING MULTIDRUG-RESISTANT GRAM-NEGATIVE BACILLI IN THREE NICUs IN ITALY • D. Vecchio, L. Saporito, C. Achille, D.M. Geraci, S. Giampietro, M. Trancassini, C. Tzialla, C.M. Maida, M. MarioABS 31. RETURN TO WORK TRAINING REQUIREMENTS FOR NEONATAL NURSES: A NETWORK SURVEY • C. Hiatt, R. Blake, J. Furness, K. Dewitt, N. Shankle, V. McFadden, P. Nath, P. SatodiaABS 32. USE OF SPECIALIST SERVICES UNTIL TWO YEARS OF AGE IN THE EPICE COHORT OF VERY PRETERM BIRTHS IN EUROPE • A.-V. Seppänen, F. Bodeau-Livinec, E.M. Boyle, A.-K. Edstedt-Bonamy, M. Cuttini, L. Toome, R.F. Maier, E. Cloet, C. Koopman-Esseboom, J. Gadzinowski, J. ZeitlinABS 33. CONGENITAL HEART DEFECTS AND THE RISK OF SPONTANEOUS PRETERM BIRTH: A NATIONWIDE STUDY OF 924,422 LIVEBORN INFANTS • N.B. Matthiesen, J.R. Østergaard, C.C. Bach, V. Hjortdal, T.B. HenriksenABS 34. THE DOSE-EFFECT RELATIONSHIP BETWEEN GESTATIONAL AGE AND SEVERE SCHOOL DIFFICULTIES – A DANISH POPULATION-BASED REGISTER STUDY • R. Wiingreen, G. Greisen, J. Svensson, B.M. HansenABS 35. RISK FACTORS ASSOCIATED WITH MORTALITY AT THE LIMIT OF VIABILITY • S. Zeballos Sarrato, N. González Pacheco, I. Pescador Chamorr, A. Rodriguez Sánchez de la Blanca, M. Sánchez LunaABS 36. TRENDS IN MORTALITY RATES AT THE LIMIT OF VIABILITY IN THE LAST DECADE • S. Zeballos Sarrato, G. Zeballos Sarrato, I. Pescador Chamorro, A, Rodriguez