Genetic and biochemical investigations of the role of MamP in redox control of iron biomineralization in Magnetospirillum magneticum.

Science.gov (United States)

Jones, Stephanie R; Wilson, Tiffany D; Brown, Margaret E; Rahn-Lee, Lilah; Yu, Yi; Fredriksen, Laura L; Ozyamak, Ertan; Komeili, Arash; Chang, Michelle C Y

2015-03-31

Magnetotactic bacteria have evolved complex subcellular machinery to construct linear chains of magnetite nanocrystals that allow the host cell to sense direction. Each mixed-valent iron nanoparticle is mineralized from soluble iron within a membrane-encapsulated vesicle termed the magnetosome, which serves as a specialized compartment that regulates the iron, redox, and pH environment of the growing mineral. To dissect the biological components that control this process, we have carried out a genetic and biochemical study of proteins proposed to function in iron mineralization. In this study, we show that the redox sites of c-type cytochromes of the Magnetospirillum magneticum AMB-1 magnetosome island, MamP and MamT, are essential to their physiological function and that ablation of one or both heme motifs leads to loss of function, suggesting that their ability to carry out redox chemistry in vivo is important. We also develop a method to heterologously express fully heme-loaded MamP from AMB-1 for in vitro biochemical studies, which show that its Fe(III)-Fe(II) redox couple is set at an unusual potential (-89 ± 11 mV) compared with other related cytochromes involved in iron reduction or oxidation. Despite its low reduction potential, it remains competent to oxidize Fe(II) to Fe(III) and mineralize iron to produce mixed-valent iron oxides. Finally, in vitro mineralization experiments suggest that Mms mineral-templating peptides from AMB-1 can modulate the iron redox chemistry of MamP.

Light irradiation helps magnetotactic bacteria eliminate intracellular reactive oxygen species.

Science.gov (United States)

Li, Kefeng; Wang, Pingping; Chen, Chuanfang; Chen, Changyou; Li, Lulu; Song, Tao

2017-09-01

Magnetotactic bacteria (MTB) demonstrate photoresponse. However, little is known about the biological significance of this behaviour. Magnetosomes exhibit peroxidase-like activity and can scavenge reactive oxygen species (ROS). Magnetosomes extracted from the Magnetospirillum magneticum strain AMB-1 show enhanced peroxidase-like activity under illumination. The present study investigated the effects of light irradiation on nonmagnetic (without magnetosomes) and magnetic (with magnetosomes) AMB-1 cells. Results showed that light irradiation did not affect the growth of nonmagnetic and magnetic cells but significantly increased magnetosome synthesis and reduced intracellular ROS level in magnetic cells. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to analyse the expression level of magnetosome formation-associated genes (mamA, mms6, mms13 and mmsF) and stress-related genes (recA, oxyR, SOD, amb0664 and amb2684). Results showed that light irradiation upregulated the expression of mms6, mms13 and mmsF. Furthermore, light irradiation upregulated the expression of stress-related genes in nonmagnetic cells but downregulated them in magnetic cells. Additionally, magnetic cells exhibited stronger phototactic behaviour than nonmagnetic ones. These results suggested that light irradiation could heighten the ability of MTB to eliminate intracellular ROS and help them adapt to lighted environments. This phenomenon may be related to the enhanced peroxidase-like activity of magnetosomes under light irradiation. © 2017 Society for Applied Microbiology and John Wiley & Sons Ltd.

Co-ordinated functions of Mms proteins define the surface structure of cubo-octahedral magnetite crystals in magnetotactic bacteria.

Science.gov (United States)

Arakaki, Atsushi; Yamagishi, Ayana; Fukuyo, Ayumi; Tanaka, Masayoshi; Matsunaga, Tadashi

2014-08-01

Magnetotactic bacteria synthesize magnetosomes comprised of membrane-enveloped single crystalline magnetite (Fe3 O4 ). The size and morphology of the nano-sized magnetite crystals (Mms (Mms5, Mms6, Mms7, and Mms13), was previously isolated from the surface of cubo-octahedral magnetite crystals in Magnetospirillum magneticum strain AMB-1. Analysis of an mms6 gene deletion mutant suggested that the Mms6 protein plays a major role in the regulation of magnetite crystal size and morphology. In this study, we constructed various mms gene deletion mutants and characterized the magnetite crystals formed by the mutant strains. Comparative analysis showed that all mms genes were involved in the promotion of crystal growth in different manners. The phenotypic characterization of magnetites also suggested that these proteins are involved in controlling the geometries of the crystal surface structures. Thus, the co-ordinated functions of Mms proteins regulate the morphology of the cubo-octahedral magnetite crystals in magnetotactic bacteria. © 2014 John Wiley & Sons Ltd.

A Comparison of Methods to Measure the Magnetic Moment of Magnetotactic Bacteria through Analysis of Their Trajectories in External Magnetic Fields

Science.gov (United States)

Fradin, Cécile

2013-01-01

Magnetotactic bacteria possess organelles called magnetosomes that confer a magnetic moment on the cells, resulting in their partial alignment with external magnetic fields. Here we show that analysis of the trajectories of cells exposed to an external magnetic field can be used to measure the average magnetic dipole moment of a cell population in at least five different ways. We apply this analysis to movies of Magnetospirillum magneticum AMB-1 cells, and compare the values of the magnetic moment obtained in this way to that obtained by direct measurements of magnetosome dimension from electron micrographs. We find that methods relying on the viscous relaxation of the cell orientation give results comparable to that obtained by magnetosome measurements, whereas methods relying on statistical mechanics assumptions give systematically lower values of the magnetic moment. Since the observed distribution of magnetic moments in the population is not sufficient to explain this discrepancy, our results suggest that non-thermal random noise is present in the system, implying that a magnetotactic bacterial population should not be considered as similar to a paramagnetic material. PMID:24349185

The Bacterial Actin MamK

Science.gov (United States)

Ozyamak, Ertan; Kollman, Justin; Agard, David A.; Komeili, Arash

2013-01-01

It is now recognized that actin-like proteins are widespread in bacteria and, in contrast to eukaryotic actins, are highly diverse in sequence and function. The bacterial actin, MamK, represents a clade, primarily found in magnetotactic bacteria, that is involved in the proper organization of subcellular organelles, termed magnetosomes. We have previously shown that MamK from Magnetospirillum magneticum AMB-1 (AMB-1) forms dynamic filaments in vivo. To gain further insights into the molecular mechanisms that underlie MamK dynamics and function, we have now studied the in vitro properties of MamK. We demonstrate that MamK is an ATPase that, in the presence of ATP, assembles rapidly into filaments that disassemble once ATP is depleted. The mutation of a conserved active site residue (E143A) abolishes ATPase activity of MamK but not its ability to form filaments. Filament disassembly depends on both ATPase activity and potassium levels, the latter of which results in the organization of MamK filaments into bundles. These data are consistent with observations indicating that accessory factors are required to promote filament disassembly and for spatial organization of filaments in vivo. We also used cryo-electron microscopy to obtain a high resolution structure of MamK filaments. MamK adopts a two-stranded helical filament architecture, but unlike eukaryotic actin and other actin-like filaments, subunits in MamK strands are unstaggered giving rise to a unique filament architecture. Beyond extending our knowledge of the properties and function of MamK in magnetotactic bacteria, this study emphasizes the functional and structural diversity of bacterial actins in general. PMID:23204522

Preparation of genomic DNA from a single species of uncultured magnetotactic bacterium by multiple-displacement amplification.

Science.gov (United States)

Arakaki, Atsushi; Shibusawa, Mie; Hosokawa, Masahito; Matsunaga, Tadashi

2010-03-01

Magnetotactic bacteria comprise a phylogenetically diverse group that is capable of synthesizing intracellular magnetic particles. Although various morphotypes of magnetotactic bacteria have been observed in the environment, bacterial strains available in pure culture are currently limited to a few genera due to difficulties in their enrichment and cultivation. In order to obtain genetic information from uncultured magnetotactic bacteria, a genome preparation method that involves magnetic separation of cells, flow cytometry, and multiple displacement amplification (MDA) using phi29 polymerase was used in this study. The conditions for the MDA reaction using samples containing 1 to 100 cells were evaluated using a pure-culture magnetotactic bacterium, "Magnetospirillum magneticum AMB-1," whose complete genome sequence is available. Uniform gene amplification was confirmed by quantitative PCR (Q-PCR) when 100 cells were used as a template. This method was then applied for genome preparation of uncultured magnetotactic bacteria from complex bacterial communities in an aquatic environment. A sample containing 100 cells of the uncultured magnetotactic coccus was prepared by magnetic cell separation and flow cytometry and used as an MDA template. 16S rRNA sequence analysis of the MDA product from these 100 cells revealed that the amplified genomic DNA was from a single species of magnetotactic bacterium that was phylogenetically affiliated with magnetotactic cocci in the Alphaproteobacteria. The combined use of magnetic separation, flow cytometry, and MDA provides a new strategy to access individual genetic information from magnetotactic bacteria in environmental samples.

Magnetic guidance of the magnetotactic bacterium Magnetospirillum gryphiswaldense.

Science.gov (United States)

Loehr, Johannes; Pfeiffer, Daniel; Schüler, Dirk; Fischer, Thomas M

2016-04-21

Magnetospirillum gryphiswaldense is a magnetotactic bacterium with a permanent magnetic moment capable of swimming using two bipolarly located flagella. In their natural environment these bacteria swim along the field lines of the homogeneous geomagnetic field in a typical run and reversal pattern and thereby create non-differentiable trajectories with sharp edges. In the current work we nevertheless achieve stable guidance along curved lines of mechanical instability by using a heterogeneous magnetic field of a garnet film. The successful guidance of the bacteria depends on the right balance between motility and the magnetic moment of the magnetosome chain.

Rutes amb iOS

OpenAIRE

Nofuentes Azcárate, Pedro

2011-01-01

Projecte de l'implementació d'una aplicació per registrar i gestionar recorreguts basada al sistema operatiu iOS amb la possibilitat de sincronitzar amb un servei web sobre la plataforma Google App Engine. Proyecto de implementación de una aplicación para registrar y gestionar recorridos basada en el sistema operativo iOS con la posibilidad de sincronizar con un servicio web sobre la plataforma Google App Engine. Implementation project for an application to record and manage routes, bas...

Effect of Polyethylene Glycol on the Formation of Magnetic Nanoparticles Synthesized by Magnetospirillum magnetotacticum MS-1.

Directory of Open Access Journals (Sweden)

Hirokazu Shimoshige

Full Text Available Magnetotactic bacteria (MTB synthesize intracellular magnetic nanocrystals called magnetosomes, which are composed of either magnetite (Fe3O4 or greigite (Fe3S4 and covered with lipid membranes. The production of magnetosomes is achieved by the biomineralization process with strict control over the formation of magnetosome membrane vesicles, uptake and transport of iron ions, and synthesis of mature crystals. These magnetosomes have high potential for both biotechnological and nanotechnological applications, but it is still extremely difficult to grow MTB and produce a large amount of magnetosomes under the conventional cultural conditions. Here, we investigate as a first attempt the effect of polyethylene glycol (PEG added to the culture medium on the increase in the yield of magnetosomes formed in Magnetospirillum magnetotacticum MS-1. We find that the yield of the formation of magnetosomes can be increased up to approximately 130 % by adding PEG200 to the culture medium. We also measure the magnetization of the magnetosomes and find that the magnetosomes possess soft ferromagnetic characteristics and the saturation mass magnetization is increased by 7 %.

HTR-10GT AMBs displacement sensor design

International Nuclear Information System (INIS)

Shi Zhengang; Zha Meisheng; Zhao Lei; Sun Zhuo

2005-01-01

The 10 MW high temperature gas-cooled test module reactor (HTR-10GT) with the core made of spherical fuel elements was designed and constructed by the Institute of Nuclear and New Energy Technology of Tsinghua University in China. In the HTR-10GT, turbo-compressor and generator rotors are connected by a flexible coupling. The rotors, restricted by actual instruments and working environment, must be supported without any contact and lubrication. Active magnetic bearing (AMB), known as its advantages over the conventional bearings., such as contact-free, no-lubricating and active damping vibration, is the best way to suspend and stabilize the position of rotors of HTR-10GT. Each rotor is suspended by two radial and one axial AMBs. The radial AMB's radial gap is 0.15 mm considering the gap of 0.4 mm between the compressor stator and blades in order to protect the compressor. The control system controls the rotor position to meet the required gaps between rotor and stator through windings current. All the position information concerning radial and axial AMB is generated by sensors for measuring the displacement of the levitated body. Some typical sensors, i.e. eddy current displacement sensor, capacitive displacement sensor, can provide position information, but, quite often, unsatisfactory anti-jamming, which is a key issue for AMB systems near generator and other electric devices in HTR-10GT. Therefore, a kind of new type sensor is designed to measure the radial and axial displacements and the vibration of the rotors. This paper focuses on the design characteristics of the HTR-10GT AMBs displacement sensors and introduction of the related experiments to demonstrate its performance. (authors)

Bacterial host and reporter gene optimization for genetically encoded whole cell biosensors.

Science.gov (United States)

Brutesco, Catherine; Prévéral, Sandra; Escoffier, Camille; Descamps, Elodie C T; Prudent, Elsa; Cayron, Julien; Dumas, Louis; Ricquebourg, Manon; Adryanczyk-Perrier, Géraldine; de Groot, Arjan; Garcia, Daniel; Rodrigue, Agnès; Pignol, David; Ginet, Nicolas

2017-01-01

Whole-cell biosensors based on reporter genes allow detection of toxic metals in water with high selectivity and sensitivity under laboratory conditions; nevertheless, their transfer to a commercial inline water analyzer requires specific adaptation and optimization to field conditions as well as economical considerations. We focused here on both the influence of the bacterial host and the choice of the reporter gene by following the responses of global toxicity biosensors based on constitutive bacterial promoters as well as arsenite biosensors based on the arsenite-inducible P ars promoter. We observed important variations of the bioluminescence emission levels in five different Escherichia coli strains harboring two different lux-based biosensors, suggesting that the best host strain has to be empirically selected for each new biosensor under construction. We also investigated the bioluminescence reporter gene system transferred into Deinococcus deserti, an environmental, desiccation- and radiation-tolerant bacterium that would reduce the manufacturing costs of bacterial biosensors for commercial water analyzers and open the field of biodetection in radioactive environments. We thus successfully obtained a cell survival biosensor and a metal biosensor able to detect a concentration as low as 100 nM of arsenite in D. deserti. We demonstrated that the arsenite biosensor resisted desiccation and remained functional after 7 days stored in air-dried D. deserti cells. We also report here the use of a new near-infrared (NIR) fluorescent reporter candidate, a bacteriophytochrome from the magnetotactic bacterium Magnetospirillum magneticum AMB-1, which showed a NIR fluorescent signal that remained optimal despite increasing sample turbidity, while in similar conditions, a drastic loss of the lux-based biosensors signal was observed.

Desenvolupament d'aplicacions web en Django sobre servidor apache, gestionades amb mòdul WSGI i relacionades amb base de dades Postgresql

OpenAIRE

Bosch Gascón, Carlos

2013-01-01

Desenvolupament d'aplicacions web en Django per al Segon Concurs de fotografia matemàtica FotoMath 2011. Allotjades en servidor Apachez, gestionades amb mòdul wsgi i relacionades amb una base de dades postgresql.

The Pseudomonas aeruginosa antimetabolite L-2-amino-4-methoxy-trans-3-butenoic acid (AMB is made from glutamate and two alanine residues via a thiotemplate-linked tripeptide precursor

Directory of Open Access Journals (Sweden)

Nelson eRojas Murcia

2015-03-01

Full Text Available The Pseudomonas aeruginosa toxin L-2-amino-4-methoxy-trans-3-butenoic acid (AMB is a non-proteinogenic amino acid which is toxic for prokaryotes and eukaryotes. Production of AMB requires a five-gene cluster encoding a putative LysE-type transporter (AmbA, two nonribosomal peptide synthetases (AmbB and AmbE, and two iron(II/α-ketoglutarate-dependent oxygenases (AmbC and AmbD. Bioinformatics analysis predicts one thiolation (T domain for AmbB and two T domains (T1 and T2 for AmbE, suggesting that AMB is generated by a processing step from a precursor tripeptide assembled on a thiotemplate. Using a combination of ATP-PPi exchange assays, aminoacylation assays, and mass spectrometry-based analysis of enzyme-bound substrates and pathway intermediates, the AmbB substrate was identified to be L-alanine (L-Ala, while the T1 and T2 domains of AmbE were loaded with L-glutamate (L-Glu and L-Ala, respectively. Loading of L-Ala at T2 of AmbE occurred only in the presence of AmbB, indicative of a trans loading mechanism. In vitro assays performed with AmbB and AmbE revealed the dipeptide L-Glu-L-Ala at T1 and the tripeptide L-Ala-L-Glu-L-Ala attached at T2. When AmbC and AmbD were included in the assay, these peptides were no longer detected. Instead, an L-Ala-AMB-L-Ala tripeptide was found at T2. These data are in agreement with a biosynthetic model in which L-Glu is converted into AMB by the action of AmbC, AmbD and tailoring domains of AmbE. The importance of the flanking L-Ala residues in the precursor tripeptide is discussed.

La hipoteràpia aplicada en alumnes amb trastorn de l'espectre autista

OpenAIRE

Sánchez i García, Lorena

2015-01-01

A continuació, es pot trobar un treball de recerca i investigació, conegut amb el nom de Treball final de Grau. El tema principal d’aquest estudi és sobre la hipoteràpia aplicada a alumnes amb autisme, per aquest motiu la principal finalitat d’aquesta recerca és identificar i conèixer com beneficia la teràpia amb cavalls a l’alumnat amb Trastorn de l’Espectre Autista. Per portar a terme aquest procés d’investigació ha sigut necessari el disseny d’un projecte d’investigació que, entre d’alt...

Regulador de carrega solar amb algorisme de carrega interactiu

OpenAIRE

Hernàndez Folguera, Marc

2016-01-01

Amb la intenció de fomentar l'ús de l'energia solar, reduint així la dependència amb els combustibles fóssils, s'ha desenvolupat un regulador de carrega solar. Aquest regulador optimitza tant la vida útil de les bateries, com el seu temps de càrrega. Utilitza un algorisme de càrrega interactiu. With the intention to encourage the use of solar power, reducing fossil fuel dependency, a solar charge controller has been developed. This controller optimizes both the batteries' lifetime and its ...

Gestió d'activitats esportives amb client Android i servidor Drupal

OpenAIRE

Cabeza López, Jordi

2011-01-01

Projecte que té per objectiu dissenyar i implementar una plataforma client/servidor basada en dues tecnologies de codi obert conegudes, com ara Drupal pel servidor web, i Android per les aplicacions de dispositius mòbils. La comunicació entre ambdós es farà amb una interfície amb tecnologia estàndard Web Services/JSON .

Desenvolupament d'aplicació web amb integració contínua

OpenAIRE

Comas Torres, Diego

2015-01-01

Desenvolupament d'una aplicació web d'enquestes amb integració contínua amb tecnologies Jenkins, TDD i JavaScript com Node JS, Angular JS i MongoDB. Desarrollo de una aplicación web de encuestas con integración continua con tecnologías Jenkins, TDD y JavaScript como Node JS, Angular JS y MongoDB. Bachelor thesis for the Computer Science program.

The design of a multisource americium-beryllium (Am-Be) neutron irradiation facility using MCNP for the neutronic performance calculation.

Science.gov (United States)

Sogbadji, R B M; Abrefah, R G; Nyarko, B J B; Akaho, E H K; Odoi, H C; Attakorah-Birinkorang, S

2014-08-01

The americium-beryllium neutron irradiation facility at the National Nuclear Research Institute (NNRI), Ghana, was re-designed with four 20 Ci sources using Monte Carlo N-Particle (MCNP) code to investigate the maximum amount of flux that is produced by the combined sources. The results were compared with a single source Am-Be irradiation facility. The main objective was to enable us to harness the maximum amount of flux for the optimization of neutron activation analysis and to enable smaller sample sized samples to be irradiated. Using MCNP for the design construction and neutronic performance calculation, it was realized that the single-source Am-Be design produced a thermal neutron flux of (1.8±0.0007)×10(6) n/cm(2)s and the four-source Am-Be design produced a thermal neutron flux of (5.4±0.0007)×10(6) n/cm(2)s which is a factor of 3.5 fold increase compared to the single-source Am-Be design. The criticality effective, k(eff), of the single-source and the four-source Am-Be designs were found to be 0.00115±0.0008 and 0.00143±0.0008, respectively. Copyright © 2014 Elsevier Ltd. All rights reserved.

Characteristics of the quarry as shielding for "2"4"1AmBe neutrons and monoenergetic photons

International Nuclear Information System (INIS)

Vega C, H. R.; Hernandez D, V. M.; Letechipia de L, C.; Salas L, M. A.; Rodriguez R, J. A.; Juarez A, C. A.

2016-09-01

Shielding is an important element in radiation protection since allows the management of radiation sources. Currently there are different materials of natural or anthropogenic origin that are used as shielding for both photons and neutrons. The quarry is a material of natural origin and abundant in our country, which is used in construction or for the manufacture of sculptures, however its characteristics as shielding have not been reported. In this paper we report some of the properties of the quarry as shielding for monoenergetic photons and for neutrons produced by an isotopic neutron source of "2"4"1AmBe. A quarry piece was used to determine its density and its chemical composition, with the XCOM code the elemental composition was determined and the mass interaction and total attenuation coefficients of the quarry were determined with photons of 10"-"3 to 10"-"5 MeV; the interaction coefficients included coherent dispersion, photoelectric absorption, Compton dispersion and the production of pairs in the nuclear and electronic field. Using the MCNP5 code, a narrow geometry attenuation experiment was modeled and the photon fluence was estimated that reaches a point detector at a distance of 42 cm from a point source, isotropic and monoenergetic photon when the source and the point detector were added quarry pieces of different thicknesses. The reduction of the number of photons as a function of the thickness of the quarry was used to determine the coefficient of linear attenuation of the quarry before photons of 0.03, 0.07, 0.1, 0.3, 1, 2 and 3 MeV that were the same as those calculated with the XCOM code. With the MCNP, the K a and H(10) transmission curves were also calculated. This same model was used to determined the variation of the "2"4"1AmBe neutron spectrum as a function of quarry thickness, as well as the E_R_O_T and H(10) transmission curves. (Author)

Etiquetatge automàtic de rols semàntics amb un sistema d'aprenentatge basat en memòria

Directory of Open Access Journals (Sweden)

Roser Morante

2008-05-01

Full Text Available En aquest article presentem un sistema d'etiquetatge automàtic de rols semàntics, el principal component del qual és un classificador basat en memòria. El sistema s'estat entrenat amb el corpus Cast3LB-CoNLL-SemRol. Els atributs codifiquen informació de sintaxi de dependències. Els resultats obtinguts (F1 0,86 són comparables amb els dels sistemes existents (F1 entorn de 0,86, que utilitzen informació de sintaxi de constituents. Text complet (PDF

Neutron and gamma-ray spectra of 239PuBe and 241AmBe

International Nuclear Information System (INIS)

Vega-Carrillo, H.R.; Manzanares-Acuna, Eduardo; Becerra-Ferreiro, A.M.; Carrillo-Nunez, Aureliano

2002-01-01

Neutron and gamma-ray spectra of 239 PuBe and 241 AmBe were measured and their dosimetric features were calculated. Neutron spectra were measured using a multisphere neutron spectrometer with a 6 LiI(Eu) scintillator. The 239 PuBe neutron spectrum was measured in an open environment, while the 241 AmBe neutron spectrum was measured in a closed environment. Gamma-ray spectra were measured using a NaI(Tl) scintillator using the same experimental conditions for both sources. The effect of measuring conditions for the 241 AmBe neutron spectrum indicates the presence of epithermal and thermal neutrons. The low-resolution neutron spectra obtained with the multisphere spectrometer allows one to calculate the dosimetric features of neutron sources. At 100 cm both sources produce approximately the same count rate as that of the 4.4 MeV gamma-ray per unit of alpha emitter activity

Provada amb èxit en cabres una nova vacuna contra la tuberculosi

OpenAIRE

Pérez del Val, Bernat

2014-01-01

Investigadors del CReSA proven per primer cop i amb èxit una nova vacuna contra la tuberculosi que millora la protecció de l’única vacuna existent en l’actualitat, l’eficàcia de la qual és força limitada. Els estudis s’han realitzat emprant cabres domèstiques, que reprodueixen amb elevada similitud les característiques patològiques i la resposta immunològica a la infecció tuberculosa activa en humans i que, pel fet de ser hostes naturals de la tuberculosi, també permeten estudiar l’ús potenci...

Telerehabilitació en pacients amb accidents cerebrovascular: revisió bibliogràfica.

OpenAIRE

Riba Lafarga, Roger

2014-01-01

L’ ictus és una alteració brusca de la circulació de la sang al cervell, sent la segona causa de mort al món i la primera en discapacitat. Objectius. Examinar si la telerehabilitació i la realitat virtual poden millorar l'estat físic i psíquic dels pacients amb accident cerebrovascular i avaluar l’impacte en les activitats de la vida diària. Conclusió. Els resultats indiquen que la fisioteràpia convencional i un programa combinat de telerehabilitació o realitat virtual amb fisioteràpia, mi...

Efectivitat de la hipoteràpia en persones amb demència tipus Alzheimer de fase lleu.

OpenAIRE

Beà Muro, Laura

2015-01-01

La hipoteràpia és més efectiva que un programa convencional d’estimulació cognitiva en el tractament de pacients amb demència tipus Alzheimer de fase lleu no institucionalitzats? En l’actualitat, no existeix cap tractament que detingui l'avanç de la malaltia d'Alzheimer (MA). Les teràpies farmacològiques en persones que pateixen la MA en estadi lleu i moderat es complementen cada vegada amb major freqüència amb tractaments no farmacològics. L'objectiu és el de minimitzar l'impacte neurodeg...

Vàlvula aòrtica bicúspide en pacients amb arrel aòrtica dilatada: anàlisi de la prevalença, dels factors predictors i relació amb la insuficiència aòrtica

OpenAIRE

Alegret i Colomé, Josep Maria

2004-01-01

Consultable des del TDX Títol obtingut de la portada digitalitzada Introducció Encara que la presència d'una vàlvula aòrtica bicúspide s'ha relacionat amb una elevada prevalença d'arrel aòrtica dilatada, la prevalença de vàlvula aòrtica bicúspide en pacients amb arrel aòrtica dilatada és desconeguda. El mètode de rutina per l'estudi morfològic i funcional de la vàlvula aòrtica és l'ecocardiograma. En pacients amb arrel aòrtica dilatada és freqüent detectar una insuficiència aòrtica. No ...

Neteja d’aigua contaminada amb ferro

OpenAIRE

Tortosa Moreno, Montserrat

2008-01-01

A molts processos químics industrials, com poden ser les extraccions mineres o les fàbriques de bateries, s’obté com a residu aigua que conté ions metàl·lics dissolts. L’aigua contaminada amb metalls és nociva si entra a formar part d’una xarxa tròfica. Per exemple, si s’utilitza aquesta aigua residual per a regar horts pot provocar una acumulació de metalls en cadena en els organismes vius, molt perjudicial. Així doncs, cal eliminar els metalls abans d’abocar l’aigua a la claveguera....

Implicació de les infermeres en la terapia assistida amb gossos en pacients amb Alzheimer moderat

OpenAIRE

González Vega, Nerea del Mar

2017-01-01

Introducció. Amb l’augment de l’esperança de vida s’està produint un envelliment crònic de la població que suposa l’aparició d’una gran varietat de malalties degeneratives com ara la demència. L’Alzheimer, sent el tipus més freqüent està afectant a una gran part de la població que, en general, acaba sent institucionalitzada en les fases més avançades. Degut a la gran controvèrsia de l’eficàcia del tractament farmacològic, cada cop són més les alternatives no farmacològiques ...

Characterization of a sealed Americium-Beryllium (AmBe) source by inductively coupled plasma mass spectrometry

International Nuclear Information System (INIS)

Sommers, J.; Jimenez, M.; Adamic, M.; Giglio, J.; Carney, K.

2009-01-01

Two Americium-Beryllium neutron sources were dismantled, sampled (sub-sampled) and analyzed via inductively coupled plasma mass spectrometry (ICP-MS). Characteristics such as 'age' since purification, actinide content, trace metal content and inter and intra source composition were determined. The 'age' since purification of the two sources was determined to be 25.0 and 25.4 years, respectively. The systematic uncertainties in the 'age' determination were ±4% 2σ. The amount and isotopic composition of U and Pu varied substantially between the sub-samples of Source 2 (n = 8). This may be due to the physical means of sub-sampling or the way the source was manufactured. Source 1 was much more consistent in terms of content and isotopic composition (n = 3 sub-samples). The Be-Am ratio varied greatly between the two sources. Source 1 had an Am-Be ratio of 6.3 ± 52% (1σ). Source 2 had an Am-Be ratio of 9.81 ± 3.5% (1σ). In addition, the trace element content between the samples varied greatly. Significant differences were determined between Sources 1 and 2 for Sc, Sr, Y, Zr, Mo, Ba and W. (author)

Teclat virtual amb predicció del llenguatge

OpenAIRE

Creus Casassas, Eloi

2012-01-01

L'objectiu de la realització d'aquest treball és la creació d'un teclat virtual destinat a ajudar a persones amb mobilitat reduïda, que no poden utilitzar el teclat físic de l'ordinador, a escriure intentant aconseguir una velocitat d'escriptura raonable per a textos de qualsevol mida. Per aconseguir aquesta velocitat d'escriptura raonable s'ha implementat un sistema de predicció del llenguatge que té dos aspectes. D'una banda es prediuen paraules segons la seva freqüència d...

Neutron and gamma-ray spectra of {sup 239}PuBe and {sup 241}AmBe

Energy Technology Data Exchange (ETDEWEB)

Vega-Carrillo, H.R. E-mail: rvega@cantera.reduaz.mx; Manzanares-Acuna, Eduardo; Becerra-Ferreiro, A.M.; Carrillo-Nunez, Aureliano

2002-08-01

Neutron and gamma-ray spectra of {sup 239}PuBe and {sup 241}AmBe were measured and their dosimetric features were calculated. Neutron spectra were measured using a multisphere neutron spectrometer with a {sup 6}LiI(Eu) scintillator. The {sup 239}PuBe neutron spectrum was measured in an open environment, while the {sup 241}AmBe neutron spectrum was measured in a closed environment. Gamma-ray spectra were measured using a NaI(Tl) scintillator using the same experimental conditions for both sources. The effect of measuring conditions for the {sup 241}AmBe neutron spectrum indicates the presence of epithermal and thermal neutrons. The low-resolution neutron spectra obtained with the multisphere spectrometer allows one to calculate the dosimetric features of neutron sources. At 100 cm both sources produce approximately the same count rate as that of the 4.4 MeV gamma-ray per unit of alpha emitter activity.

L'aferrament adult en dones adoptades: relació amb la construcció de la identitat

OpenAIRE

Garcia Sala, Laia

2016-01-01

Aquest estudi parteix d’un posicionament constructivista relacional (Botella, Herrero, Pacheco i Corbella, 2004) i de la Teoria de l’Aferrament (Bowlby, 1969) i de l’Aferrament Adult (Hazan i Shaver, 1987) per a l’anàlisi d’aquest últim i de la seva relació amb la construcció de la identitat de 15 dones adoptades amb fills biològics. Per tal de dur-ho a terme, es va treballar a partir d’una entrevista semi- estructurada, del qüestionari auto-aplicat ECR-S (Alonso- Arbiol, Balluerka i Shaver, ...

Desenvolupament d'una aplicació per Internet amb Java2 EE.TFC Intranet Escolar

OpenAIRE

Mistou Fité, Elena

2012-01-01

L'objectiu principal de l'aplicació serà la de proporcionar una eina més de comunicació entre l'escola, els professors i les famílies dels alumnes. Aquest projecte s'ha desenvolupat en Java amb implementació del patró MVC amb Struts2. Per al tractament de la persistència de les dades, s'ha utilitzat Hibernate y MySql com a base de dades. El objetivo principal de la aplicación será la de proporcionar una herramienta más de comunicación entre la escuela, los profesores y las familias de los...

Neutron calibration facility with an Am-Be source for pulse shape discrimination measurement of CsI(Tl) crystals

International Nuclear Information System (INIS)

Lee, H.S.; Bhang, H.; Choi, J.H.; Choi, S.; Joo, H.W.; Kim, G.B.; Kim, K.W.; Kim, S.C.; Kim, S.K.; Lee, J.H.; Lee, J.K.; Myung, S.S.; Hahn, I.S.; Jeon, E.J.; Kang, W.G.; Kim, Y.D.; Kim, Y.H.; Li, J.; Kim, H.J.; Leonard, D.S.

2014-01-01

We constructed a neutron calibration facility based on a 300-mCi Am-Be source in conjunction with a search for weakly interacting massive particle candidates for dark matter. The facility is used to study the response of CsI(Tl) crystals to nuclear recoils induced by neutrons from the Am-Be source and comparing them with the response to electron recoils produced by Compton scattering of 662-keV γ-rays from a 137 Cs source. The measured results on pulse shape discrimination (PSD) between nuclear- and electron-recoil events are quantified in terms of quality factors. A comparison with our previous result from a neutron generator demonstrate the feasibility of performing calibrations of PSD measurements using neutrons from a Am-Be source

Disseny i validació d’una plataforma de telemedicina de suport al tractament de pacients amb diabetis tipus 1: iDOSING

OpenAIRE

Saigí i Ullastret, Ignasi

2011-01-01

La diabetis tipus 1 és una malaltia crònica que condiciona una disminució de la qualitat i esperança de vida de les persones que la pateixen. Últimament han aparegut avenços tecnològics que poden millorar aquests paràmetres, però a costa de generar un gran volum d'informació difícil d'interpretar per part dels professionals amb l'assistència presencial actual. En aquest context hem creat i validat una plataforma telemèdica (iDosing) dissenyada per millorar la interacció metge-pacient i al mat...

The 2-(acetoxymethyl)benzoyl (AMB) group as a new base-protecting group, designed for the protection of (phosphate) modified oligonucleotides.

NARCIS (Netherlands)

Kuijpers, W.H.A.; Huskens, J.; Boeckel, van C.A.A.

1990-01-01

The 2-(acetoxymethyl)benzoyl (AMB) group is a new base-protecting group that facilitates the synthesis of labile, modified nucleotides, since it can be rapidly cleaved under mild basic conditions. The 2-(acetoxymethyl)benzoyl (AMB) group is a new base-protecting group that facilitates the synthesis

Response of LR-115 type II and CR-39 plastic track detectors to Am-Be and 14.1-MeV neutrons

International Nuclear Information System (INIS)

Bradley, D.A.; Chong, C.S.; Saat, Ahmat; Sidik, A.G.; Ghose, A.M.

1987-01-01

The fast-neutron response of the plastic LR-115 type II and CR-39 track detectors have been compared, using a 14.1-MeV neutron generator and a radionuclide Am-Be neutron source (effective primary neutron energy 4.5-MeV). The distribution of track diameters for a range of etching times has been evaluated, taking into account track registration efficiency and the relevant fast neutron scattering cross-sections. The efficiency of etched-track formation in LR-115 type II due to neutron irradiation is approximately double that in CR-39. The 14.1-MeV neutrons also tend to produce tracks in both materials with somewhat greater efficiency than do the lower energy neutrons from the radionuclide source, for a given etching time. (author)

Shielding of a neutron irradiator with {sup 241}Am-Be source

Energy Technology Data Exchange (ETDEWEB)

Oliveira, K.A.M. de; Crispim, V.R.; Silva, A.X., E-mail: koliveira@con.ufrj.b, E-mail: verginia@con.ufrj.b, E-mail: ademir@con.ufrj.b [Universidade Federal do Rio de Janeiro (PEN/COPPE/UFRJ), RJ (Brazil). Coordenacao dos Programas de Pos-Graduacao de Engenharia. Programa de Engenharia Nuclear; Fonseca, E.S., E-mail: evaldo@ird.gov.b [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

2011-07-01

The equivalent dose rates at 1.0 cm from the outer surface of the shielding of a neutron irradiation system that uses {sup 241}Am-Be source with activity of 185 GBq (5 Ci) were determined. A theoretical-experimental approach including case studies, through computer simulations with MCNP code was employed to calculate the best shielding thickness. Following the construction of the neutron irradiator, dose measurements were conducted in order to validate data obtained from simulation. The neutron irradiator shielding was designed in such a way to allow transport of the neutron radiography system for in loco inspections ensuring workers' radiologic safety. (author)

Ensenyar amb casos audiovisuals en l'entorn virtual: metodologia i resultats

OpenAIRE

Triadó i Ivern, Xavier Ma.; Aparicio Chueca, Ma. del Pilar (María del Pilar); Jaría Chacón, Natalia; Gallardo-Gallardo, Eva; Elasri Ejjaberi, Amal

2010-01-01

Aquest quadern pretén posar i donar a conèixer les bases d'una metodologia que serveixi per engegar experiències d'aprenentatge amb casos audiovisuals en l'entorn del campus virtual. Per aquest motiu, s'ha definit un protocol metodològic per utilitzar els casos audiovisuals dins l'entorn del campus virtual a diferents assignatures.

Dr. Stefan Ambs: Increasing Diversity in Cancer Research: One Lab at a Time

Science.gov (United States)

As part of the series “Increasing Diversity in Cancer Research,” CRCHD interviewed Dr. Stefan Ambs, an investigator at NCI’s Center for Cancer Research, who is using novel approaches to discover gene differences in the tumors of African American patients.

Amb M. Antònia Canals al Nepal de Viki Sherpa

OpenAIRE

Siqués, Carina

1999-01-01

Relació del viatge fet per la Maria Antònia Canals a Nepal amb motiu de l’acte de celebració de la signatura del conveni de col·laboració entre la Universitat de Tribhuvan a Katmandu i la Universitat de Vic per crear el centre de formació del professorat d’infantil i de primària M. Antònia Canals

Enriquint la realitat: realitat augmentada amb estudiants d'Educació Social

Directory of Open Access Journals (Sweden)

Linda Castañeda Quintero

2014-06-01

Full Text Available En aquest article presentem una experiència d'innovació educativa duta a terme amb estudiants de 1r de Grau en Educació Social en el marc de l'assignatura TIC en Educació Social. Presentem a continuació una descripció detallada de la tasca duta a terme, a més dels principals resultats que hem obtingut. Entenem que aquests resultats incideixen en la necessitat d'aprofundir en la importància de l'aprenentatge autònom, basat en un treball d'aprenentatge per tasques, que entengui als estudiants com a persones capaces d'emprendre tasques complexes que els portin al desenvolupament de processos cognitius superiors i de gran qualitat en el marc dela seva educació.

Investigation of some possible changes in Am-Be neutron source configuration in order to increase the thermal neutron flux using Monte Carlo code

Science.gov (United States)

Basiri, H.; Tavakoli-Anbaran, H.

2018-01-01

Am-Be neutrons source is based on (α, n) reaction and generates neutrons in the energy range of 0-11 MeV. Since the thermal neutrons are widely used in different fields, in this work, we investigate how to improve the source configuration in order to increase the thermal flux. These suggested changes include a spherical moderator instead of common cylindrical geometry, a reflector layer and an appropriate materials selection in order to achieve the maximum thermal flux. All calculations were done by using MCNP1 Monte Carlo code. Our final results indicated that a spherical paraffin moderator, a layer of beryllium as a reflector can efficiently increase the thermal neutron flux of Am-Be source.

Recoly, repositori de records : Webapp amb HTML5, CSS3 i JavaScript

OpenAIRE

Cantón Gavilán, Sergio

2012-01-01

Projecte d'implementació d'una aplicació web mòbil per enregistrar records amb LungoJS, PHP i MySQL. Estudi comparatiu de frameworks. Proyecto de implementación de una aplicación web móvil para grabar recuerdos con LungoJS, PHP y MySQL. Estudio comparativo de frameworks.

Medical observation and evaluation of persons accidentally exposed to 241Am-Be neutron source

International Nuclear Information System (INIS)

Li Jinbang; Bai Yushu; Zhang Jiayu

1986-01-01

A radiation accident caused by an 241 Am-Be source is reported. A boy, 17 years old, brought an 241 Am-Be source of 120 mCi to home and drilled a hole in it. In all 10 persons were irradiated with varying doses and were contaminated to different extent. The maximum dose of external exposure was 121 x 10 -3 Gy and the maximum concentration of urinary 241 Am was 2.8 dpm. The exposed persons felt dizziness, palpitation and myalgia at the early stage. At that time there were slight increase in leucocyte counts, presence of heterogeneous lymphocytes and increase in frequency of leucocyte spinous process. Follow-up study for one and a half years on general health condition, hematological changes, immune function (T-and B-lymphocytes) and crystalline lens alterations revealed no significant differences between the irradiated and the non-irradiated persons, but the frequencies of all types of chromosome aberrations in the irradiated group were significantly higher than those in the control group

Efectivitat de l'exoesquelet en comparació amb la hidroteràpia per a la reeducació de l'equilibri i la marxa en pacients post-ictus isquèmic

OpenAIRE

Rabasa Martín, Oscar

2016-01-01

Pregunta clínica: En la recuperació de l’equilibri i la marxa després de tres mesos d’un accident cerebrovascular isquèmic en adults, s’evidencia millora en el dolor, l’espasticitat, la dependència i la qualitat de vida amb l´ús de l’exosquelet combinat amb la fisioteràpia convencional en comparació amb la hidroteràpia i la fisioteràpia convencional? Objectius: - General: Valorar l’efectivitat de l’exosquelet comparat amb la hidroteràpia en pacients entre 65 i 85 anys diagnosticats d’...

Preparation and anti-tumor efficiency evaluation of doxorubicin-loaded bacterial magnetosomes: magnetic nanoparticles as drug carriers isolated from Magnetospirillum gryphiswaldense.

Science.gov (United States)

Sun, Jian-Bo; Duan, Jin-Hong; Dai, Shun-Ling; Ren, Jun; Guo, Lin; Jiang, Wei; Li, Ying

2008-12-15

Bacterial magnetosomes (BMs) are commonly used as vehicles for certain enzymes, nucleic acids and antibodies, although they have never been considered drug carriers. To evaluate the clinical potential of BMs extracted from Magnetospirillum gryphiswaldense in cancer therapy, doxorubicin (DOX) was loaded onto the purified BMs at a ratio of 0.87 +/- 0.08 mg/mg using glutaraldehyde. The DOX-coupled BMs (DBMs) and BMs exhibited uniform sizes and morphology evaluated by TEM. The diameters of DBMs and BMs obtained by AFM were 71.02 +/- 6.73 and 34.93 +/- 8.24 nm, respectively. The DBMs released DOX slowly into serum and maintained at least 80% stability following 48 h of incubation. In vitro cytotoxic tests showed that the DBMs were cytotoxic to HL60 and EMT-6 cells, manifested as inhibition of cell proliferation and suppression in c-myc expression, consistent with DOX. These observations depicted in vitro antitumor property of DBMs similar to DOX. The approach of coupling DOX to magnetosomes may have clinical potential in anti-tumor drug delivery.

El cas estrany d'una nena amb tuberculosi renal

OpenAIRE

Martínez Roig, Antonio

2009-01-01

La tuberculosi és una afecció més pròpia de localitzar-se als pulmons, a través del contagi per via aèria, que no pas fora d'ells. La que es produeix als ronyons seria només un 3% i la infecció estaria vinculada a la disseminació per via sanguínia i limfàtica de la tuberculosi pulmonar. Si considerem que la tuberculosi es diagnostica principalment a l'adolescència, trobarem força peculiar el cas d'una nena que va desenvolupar una tuberculosi renal amb tretze mesos de vida. La nena patia una d...

L’anàlisi de conglomerats bietàpic o en dues fases amb SPSS

Directory of Open Access Journals (Sweden)

Maria-José Rubio-Hurtado

2017-01-01

Full Text Available El procediment d'anàlisi de conglomerats en dues fases, també anomenat bietàpic, és una eina d'exploració dissenyada per descobrir les agrupacions naturals d'un conjunt de dades. Permet la generació de criteris d'informació, freqüències dels conglomerats i estadístics descriptius per conglomerat, així com gràfics de barres, sectors i gràfics d'importància de les variables. El mètode d'anàlisi de conglomerats en dues fases té unes funcions úniques respecte a altres mètodes de conglomeració tradicionals, com són: un procediment automàtic del nombre òptim de conglomerats, la possibilitat de crear models de conglomerats amb variables tant categòriques com contínues, o la possibilitat de treballar amb arxius de dades de grans dimensions.

Installation and measurement capacity of 3 x 592 GBq 241Am-Be neutron irradiation cell

International Nuclear Information System (INIS)

Bulut, Serdar; Celenk, I.

2013-01-01

In this study, the installation and measurement capacity of the neutron irradiation system are investigated. First of all an irradiation geometry enabling optimum irradiation was designed for three 241 Am-Be sources each of it having 592 GBq activity. Neutron irradiation system was installed after design and optimization of the system including the design of appropriate moderator and shielding were completed. Radiation safety standards of the Neutron Research Laboratory fulfilling the requirements of national regulation were achieved with unique configuration of the shielding materials. In this study the results of qualitative and quantitative detection limits obtained for Na, Al, Cl, K, Ti, V, Mn, Fe, Co, Cu, Zn, Ga, Ge, As, Se, Br, Rb, Sr, Y, Mo, Ru, Ag, Cd, In, Sb, I, Cs, Ba, La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Ho, Yb, Lu, Hf, W, Pt, Au, Th and U elements by using the neutron irradiation cell comprising 3 x 592 GBq 241 Am-Be isotopic neutron source are presented and discussed. (orig.)

The cation diffusion facilitator proteins MamB and MamM of Magnetospirillum gryphiswaldense have distinct and complex functions, and are involved in magnetite biomineralization and magnetosome membrane assembly

DEFF Research Database (Denmark)

Uebe, René; Junge, Katja; Henn, Verena

2011-01-01

Magnetotactic bacteria form chains of intracellular membrane‐enclosed, nanometre‐sized magnetite crystals for navigation along the earth's magnetic field. The assembly of these prokaryotic organelles requires several specific polypeptides. Among the most abundant proteins associated with the magn......Magnetotactic bacteria form chains of intracellular membrane‐enclosed, nanometre‐sized magnetite crystals for navigation along the earth's magnetic field. The assembly of these prokaryotic organelles requires several specific polypeptides. Among the most abundant proteins associated...... with the magnetosome membrane of Magnetospirillum gryphiswaldense are MamB and MamM, which were implicated in magnetosomal iron transport because of their similarity to the cation diffusion facilitator family. Here we demonstrate that MamB and MamM are multifunctional proteins involved in several steps of magnetosome...

Efectivitat de la Electròlisi Percutània Intratissular per a la reducció del dolor i l’augment de la qualitat de vida en esportistes amateurs amb tendinopatia rotuliana crònica: Assaig clínic aleatoritzat

OpenAIRE

Roldan Reinoso, Sergi

2017-01-01

Pregunta clínica: La recuperació de la tendinopatia rotuliana crònica de 6 mesos d’evolució, en persones que practiquen esport de forma amateur, serà més beneficiosa amb l’ús de l’Electròlisi Percutània Intratissular o amb un tractament basat amb exercicis excèntrics? Objectius: - General: Valorar l’efectivitat de l’Electròlisi Percutània Intratissular en comparació amb el tractament amb exercicis excèntrics en pacients esportistes amateurs diagnosticats de tendinopatia rotuliana. - ...

Determination of europium content in Li_2SiO_3(Eu) by neutron activation analysis using Am-Be neutron source

International Nuclear Information System (INIS)

Naik, Yeshwant; Tapase, Anant Shamrao; Mhatre, Amol; Datrik, Chandrashekhar; Tawade, Nilesh; Kumar, Umesh; Naik, Haladhara

2016-01-01

Circulardiscs of Li_2SiO_3 doped with europium were prepared and a new activation procedure for the neutron dose estimation in a breeder blanket of fusion reactor is described. The amount of europium in the disc was determined by neutron activation analysis (NAA) using an isotopic neutron source. The average neutron absorption cross section for the reaction was calculated using neutron distribution of the Am-Be source and available neutron absorption cross section data for the "1"5"1Eu(n,γ)"1"5"2"mEu reaction, which was used for estimation of europium in the pallet. The cross section of the elements varies with neutron energy, and the flux of the neutrons in each energy range seen by the nuclei under investigation also varies. Neutron distribution spectrum of the Am-Be source was worked out prior to NAA and the effective fractional flux for the nuclear reaction considered for the flux estimation was also determined. - Highlights: • Lithium meta-silicate is breeder materials for a fusion reactor. • Europium is used for neutron dose estimation in a breeder blanket. • It is important to determine amount of europium in lithium meta-silicate. • Amount of europium in lithium meta-silicate was determined by neutron activation and off-line gamma spectrometry.

Detection limits of pollutants in water for PGNAA using Am-Be source

International Nuclear Information System (INIS)

Khelifi, R.; Amokrane, A.; Bode, P.

2007-01-01

A basic PGNAA facility with an Am-Be neutron source is described to analyze the pollutants in water. The properties of neutron flux were determined by MCNP calculations. In order to determine the efficiency curve of a HPGe detector, the prompt-gamma rays from chlorine were used and an exponential curve was fitted. The detection limits for typical water sample are also estimated using the statistical fluctuations of the background level in the areas of recorded the prompt-gamma spectrum

Sensitivity of chemically and electrochemically etched CR 39 polymers to the neutrons of AmBe source

International Nuclear Information System (INIS)

Turek, K.; Spurny, F.; Dajko, G.; Somogyi, G.

1981-01-01

Seven samples of polymers by different manufacturers were used in a study of the sensitivity of CR 39 polymers to Am-Be neutrons. In the polymer, proton tracks for a relatively broad energy range can also be recorded. The following characteristics were studied: the sample background for different etching methods, the dependence of sensitivity on the etched thickness and on neutron fluence, the effect of type and thickness of external proton emitters, and the effect of the choice of electric parameters on the resulting sensitivity in electrochemical etching. Good results were obtained when chemical and electrochemical etching was used in combination. It was found that with electrochemical etching, sensitivity decreases for neutron fluence exceeding 10 8 cm -2 . The sensitivity of the studied CR 39 polymer samples only little differed. When the most sensitive polymer was used, the minimum dose equivalent in the human body for Am-Be neutrons which could be determined using combination etching was 0.4 mSv (ie., 40 mrems). (B.S.)

Solució de monitorització d'experiència d'usuari en entorns web amb Selenium

OpenAIRE

Font Erruz, Xavier

2014-01-01

Creació d'una solució de monitorització d'experiència d'usuari en entorns web amb Selenium, en J2EE. Creación de una solución de monitorización de experiencia de usuario en entornos web con Selenium, en J2EE.

Uma lógica para a referência ambígua

OpenAIRE

Sebben, Andressa

2007-01-01

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência da Computação. Descritores são operadores que formam termos a partir de variáveis e fórmulas de sistemas lógicos. Diversas teorias introduzem descritores para representar, em linguagens formais, o artigo definido (o/a) e o artigo indefinido (um/uma) das linguagens naturais. Entretanto, as abordagens mais conhecidas não oferecem um tratamento para termos ambíguos. A lógi...

Neutron energy spectra of sup 2 sup 5 sup 2 Cf, Am-Be source and of the D(d,n) sup 3 He reaction

CERN Document Server

Sang Tae Park

2003-01-01

The neutron energy spectrum of the following sources were measured using a fast neutron spectrometer with the NE-213 liquid scintillator: sup 2 sup 5 sup 2 Cf, Am-Be and D(d,n) sup 3 He reaction from a 3 MeV Pelletron accelerator in Tokyo Institute of Technology. The measured proton recoil pulse height data of sup 2 sup 5 sup 2 Cf, Am-Be and D(d,n) sup 3 He were unfolded using the mathematical program to obtain the neutron energy spectrum. The sup 2 sup 5 sup 2 Cf and Am-Be neutron energy spectra were measured and the results obtained showed a good agreement with the spectra usually published in the literature. The neutron energy spectrum from D(d,n) sup 3 He was measured and the results obtained also showed a good agreement with the calculation by time of flight (TOF) methods. (author)

Infermeria: Disciplina pràctica entroncada amb d'altres disciplines científiques

OpenAIRE

Gusiñé, Francesca; Olivé Ferrer, M. Carmen; Pardo Fernández, Andrea

1997-01-01

L'any 1968, presentat pel grup 'conferen­cia para los diagnósticos de enfermería' apa­reix un concepte que diu: 'el treball que realitza la infermeria identifica la seva prò­pia dimensió com a disciplina pràctica' amb això es fa referència a la noció de que el producte final elaborat per la infermeria és el sistema d'infermeria com a tal...

Metabolism of the synthetic cannabinoids AMB-CHMICA and 5C-AKB48 in pooled human hepatocytes and rat hepatocytes analyzed by UHPLC-(IMS)-HR-MSE

DEFF Research Database (Denmark)

Mardal, Marie; Dalsgaard, Petur Weihe; Qi, Bing

2018-01-01

metabolites of the synthetic cannabinoids, AMB-CHMICA and 5C-AKB48, using an in silico-assisted workflow with analytical data acquired using ultra-high-performance liquid chromatography–(ion mobility spectroscopy)–high resolution–mass spectrometry in data-independent acquisition mode (UHPLC......-(IMS)-HR-MSE). The metabolites were identified after incubation with rat and pooled human hepatocytes using UHPLC-HR-MSE, followed by UHPLC-IMS-HR-MSE. Metabolites of AMB-CHMICA and 5C-AKB48 were predicted with Meteor (Lhasa Ltd) and imported to the UNIFI software (Waters). The predicted metabolites were assigned to analytical...... components supported by the UNIFI in silico fragmentation tool. The main metabolic pathway of AMB-CHMICA was O-demethylation and hydroxylation of the methylhexyl moiety. For 5C-AKB48, the main metabolic pathways were hydroxylation(s) of the adamantyl moiety and oxidative dechlorination with subsequent...

Sistema remot de monitoratge cardíac implementat amb programari lliure

OpenAIRE

Fornons Ortega, Daniel

2016-01-01

Aquest projecte té com a objectiu crear un sistema de monitoratge de baix cost que permeti als usuaris enregistrar el ritme cardíac (RC) i la variabilitat de la freqüència cardíaca (VFC) i compartir-los. A més a més, el sistema creat també es útil en el camp de l'esport per a monitorar els entrenaments dels esportistes i detectar diferents fases de la preparació com l'afinament o el sobreentrenament. Per obtenir les dades de RC i VFC s'utilitza una cinta amb un sensor de ritme cardíac comerci...

An Am-Be neutron source Accident and its management

International Nuclear Information System (INIS)

Bai Guang; Wang Xinyong; Wu Zhenghan

1988-01-01

An 241 Am-Be neutron source for inaustrial use was lost in a county of Guangdong Province in April, 1982. A school boy picked up and brought it to his home. The source was broken and 10 people were contaminated with radioactive substance. The boy (X) received the highest external irradiation, with chest dose of 0.12 Sv and hand dose of 0.32 Sv. His brother (Y) incurred the heaviest internal contamination by 241 Am, about 3.3 x 10 3 Bq. Decorporation was carried out in four persons including Y, and the excretion of 241 Am in stools and urine was increased significantly. With the medical examination performed upon these persons one and half years after the accident, no positive findings induced by radiation were found except the increase of chromosomal aberration rate in lymphocytes

DISSENYAR EXPERIÈNCIES AMB VALOR TURÍSTIC: PAISATGES URBANS

Directory of Open Access Journals (Sweden)

Francesc Fusté

2015-10-01

Full Text Available Aquest article tracta sobre les possibilitats que la creació d’experiències té en relació al desenvolupament empresarial i regional, gràcies a la tematització del sector turístic i la modificació intencional de l’entorn, tant cultural com natural. El paisatge caracteritza els espais en funció de la seva configuració territorial i també arquitectònica i urbana. Les estructures arquitectòniques, els esdeveniments i les activitats que impliquen la participació activa dels usuaris són la clau de l’èxit del disseny de les experiències amb un valor afegit, on les noves tecnologies ajuden a emfatitzar-ne l’impacte. Sigui com sigui, convertir els llocs en experiències tant pels residents com pels visitants.

Characteristics of the quarry as shielding for {sup 241}AmBe neutrons and monoenergetic photons; Caracteristicas de la cantera como blindaje para los neutrones del {sup 241}AmBe y fotones monoenergeticos

Energy Technology Data Exchange (ETDEWEB)

Vega C, H. R.; Hernandez D, V. M.; Letechipia de L, C.; Salas L, M. A. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas, Zac. (Mexico); Rodriguez R, J. A.; Juarez A, C. A., E-mail: fermineutron@yahoo.com [Universidad Autonoma de Nuevo Leon, Facultad de Ingenieria Civil, Pedro de Alba s/n, San Nicolas de los Garza, Nuevo Leon (Mexico)

2016-09-15

Shielding is an important element in radiation protection since allows the management of radiation sources. Currently there are different materials of natural or anthropogenic origin that are used as shielding for both photons and neutrons. The quarry is a material of natural origin and abundant in our country, which is used in construction or for the manufacture of sculptures, however its characteristics as shielding have not been reported. In this paper we report some of the properties of the quarry as shielding for monoenergetic photons and for neutrons produced by an isotopic neutron source of {sup 241}AmBe. A quarry piece was used to determine its density and its chemical composition, with the XCOM code the elemental composition was determined and the mass interaction and total attenuation coefficients of the quarry were determined with photons of 10{sup -3} to 10{sup -5} MeV; the interaction coefficients included coherent dispersion, photoelectric absorption, Compton dispersion and the production of pairs in the nuclear and electronic field. Using the MCNP5 code, a narrow geometry attenuation experiment was modeled and the photon fluence was estimated that reaches a point detector at a distance of 42 cm from a point source, isotropic and monoenergetic photon when the source and the point detector were added quarry pieces of different thicknesses. The reduction of the number of photons as a function of the thickness of the quarry was used to determine the coefficient of linear attenuation of the quarry before photons of 0.03, 0.07, 0.1, 0.3, 1, 2 and 3 MeV that were the same as those calculated with the XCOM code. With the MCNP, the K a and H(10) transmission curves were also calculated. This same model was used to determined the variation of the {sup 241}AmBe neutron spectrum as a function of quarry thickness, as well as the E{sub ROT} and H(10) transmission curves. (Author)

Rapid and sensitive detection of synthetic cannabinoids AMB-FUBINACA and α-PVP using surface enhanced Raman scattering (SERS)

Science.gov (United States)

Islam, Syed K.; Cheng, Yin Pak; Birke, Ronald L.; Green, Omar; Kubic, Thomas; Lombardi, John R.

2018-04-01

The application of surface enhanced Raman scattering (SERS) has been reported as a fast and sensitive analytical method in the trace detection of the two most commonly known synthetic cannabinoids AMB-FUBINACA and alpha-pyrrolidinovalerophenone (α-PVP). FUBINACA and α-PVP are two of the most dangerous synthetic cannabinoids which have been reported to cause numerous deaths in the United States. While instruments such as GC-MS, LC-MS have been traditionally recognized as analytical tools for the detection of these synthetic drugs, SERS has been recently gaining ground in the analysis of these synthetic drugs due to its sensitivity in trace analysis and its effectiveness as a rapid method of detection. This present study shows the limit of detection of a concentration as low as picomolar for AMB-FUBINACA while for α-PVP, the limit of detection is in nanomolar concentration using SERS.

Study of neutron spectra using sources of {sup 241}AmBE and {sup 238}PuBe moderated in water; Estudo de espectros neutrônicos com fontes de {sup 241}AmBE e {sup 238}PuBe moderados em água

Energy Technology Data Exchange (ETDEWEB)

Gonçalves, Angela S.; Silva, Fellipe S.; Patrão, Karla C.S.; Fonseca, Evaldo S. da; Pereira, Walsan W., E-mail: angela.souzagon@gmail.com [Instituto de Radioprotecao e Dosimetria, (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Laboratorio de Metrologia de Neutrons; Fundação Técnico-Educacional Souza Marques (FTESM), Rio de Janeiro, RJ (Brazil)

2017-11-01

Recent works demonstrate the increasing importance of characterizing the spectrum of neutron sources for various energies. The main objective of this study is to make the understanding of the interaction of neutrons as close as possible to the reality in which the workers act, thus allowing to act directly in the area of radioprotection. In this way, neutron fluence determination of the {sup 241}AmBe source of 0.6 TBq (16 Ci) and {sup 238} PuBe 1.8 TBq (50 Ci) free in the air and inserted in aluminium spheres of 16 cm and 20.5 cm filled with distilled water. The measurements were carried out in the low scattering laboratory of the Laboratory of Neutron Metrology, in order to obtain a more realistic spectrum. Spectrum determination is based on measurement using the Bonner multisphere spectrometer containing readings with the ball-free detector and covered with polyethylene spheres having diameters of: 5,08 cm (2″), 7,62 cm (3″), 12,70 cm (5″), 20,32 cm (8″), 25,40 cm (10″) e 30,48 cm (12″). The aim is to characterize a new moderate spectrum in water using the sources of {sup 238}PuBe and {sup 241}AmBe that may represent realistic fields in the radioprotection area useful for testing, calibration and irradiation of individual and area monitors for neutrons.

Study of neutron moderation using the {sup 241}Am-Be spectrum with hydrogenated materials; Estudo da moderacao de neutrons utilizando o espectro de {sup 241}Am-Be com materiais hidrogenados

Energy Technology Data Exchange (ETDEWEB)

Santos, A.R.L.; Silva, F.S.; Martins, M.M.; Pereira, W.W., E-mail: aleiras@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ/LNMRI/LN), Rio de Janeiro, RJ (Brazil). Lab. de Neutrons; Freitas, B.M. [Coordenacao dos Programas de Pos-Graduacao em Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear; Tavares, D.Y.S. [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

2014-07-01

This work intends to assess materials for moderation of neutrons, trying to reduce the rate of H{sub p}(10) and H⁎p(10), reducing the effective dose of Occupationally Exposed Workers (OEW) who handle this source daily. The neutron spectra moderated by different materials was performed with a neutron source of {sup 241}Am-Be in an electronic positioning system, using a neutron spectrometry with Bonner Sphere at 50 cm from the center of source. The materials used for moderation were paraffin, silicone and Polyvinyl Chloride (PVC) resin ball. (author)

Generació de mapes a partir d'imatges preses amb un UAV

OpenAIRE

Perarnau, Guim; Universitat Autònoma de Barcelona. Escola d'Enginyeria

2015-01-01

En els darrers anys s'ha popularitzat l'ús dels UAVs (drones) en una gran varietat d'àmbits. Aquest treball se centra en el camp de generació de mapes (vistes àrees) òptima basat en imatges enregistrades amb un UAV. Per millorar la qualitat del mapa resultant es vol treure profit de la instal•lació de sensors en l'UAV que proporcionin informació que pugui ser útil en el procés, com la posició i l'orientació de l'UAV. Com a tal, es descriuran tots els passos emprats per tal d'aprofitar les dad...

Gestió d'un catàleg de productes amb Microsoft .NET

OpenAIRE

Otero Dopico, Àngels

2007-01-01

El projecte és una aplicació de gestió d'un catàleg de productes realitzada amb la tecnologia .NET. En concret he fet servir l'entorn de programació Microsoft Visual Studio 2005 i el llenguatge Visual Basic .NET com elements principals. El proyecto es una aplicación de gestión de un catálogo de productos realizada con la tecnología .NET. En concreto se ha usado el entorno de programación Microsoft Visual Studio 2005 y el lenguaje Visual Basic .NET como elementos principales. This projec...

Nuclear data measurements in 3x592 GBq 241Am-Be neutron cell

International Nuclear Information System (INIS)

2010-01-01

accurately. Cumulative fission yield for the fission products from 2 32Th(n, f) and 2 38U(n, f) reactions in a neutron spectrum of average 5.0 MeV energy, were measured. For 2 32Th(n, f) reaction, cumulative fission yield of 16 fission products between A = 87 - 143 was measured and for 2 38U(n, f) reaction, cumulative fission yield of 33 fission products between A = 87 - 146 was measured. Neutron threshold detectors are used for determining reactor radiation damage, neutron flux measurements and in neutron dosimeters. Cross section measurements were performed for the following threshold detectors in the given neutron energies: for 1 03Rh(n, n') 1 03mRh at 4.83 MeV, for 1 15In(n, n') 1 15mIn at 4.97 MeV, for 2 32Th(n, f) at 5.02 MeV, for 2 38U(n, f) at 5.04 MeV, for 4 7Ti(n, p) 4 7Sc at 5.23 MeV, for 6 4Zn(n, p) 6 4Cu at 5.45 MeV, for 5 8Ni(n, p) 5 8Co at 5.45 MeV, for 5 4Fe(n, p) 5 4Mn at 5.71 MeV, for 4 6Ti(n, p) 4 6Sc at 6.16 MeV, for 2 7Al(n, p) 2 7Mg at 6.47 MeV, for 5 6Fe(n, p) 5 6Mn at 7.72 MeV, for 2 4Mg(n, p) 2 4Na at 8.21 MeV, for 5 9Co(n, α) 5 6Mn at 8.21 MeV, for 2 7Al(n, α) 2 4Na at 8.43 MeV and for 4 8Ti(n, p) 4 8Sc at 8.72 MeV. It is especially crucial to know accurately the gamma ray intensities of 2 34Th, 2 34mPa and 2 34gPa nuclides, which are important for the evaluation of the dose balance of depleted uranium and the efficiency calibration of the high efficiency gamma detectors and are in secular equilibrium with 2 38U. Here, intensities (decay probabilities) of 72 gamma rays of 2 34mPa and 2 34gPa nuclides were measured. In 3 x 592 GBq Am-Be neutron irradiation cell, qualitative and quantitative detection limits were determined for Na, Al, Cl, K, Ti, V, Mn, Fe, Co, Cu, Zn, Ga, Ge, As, Se, Br, Rb, Sr, Y, Mo, Ru, Ag, Cd, In, Sb, I, Cs, Ba, La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Ho, Yb, Lu, Hf, W, Pt, Au, Th and U elements. By using the cyclic activation analysis method, half lives of 2 8Al, 5 2V, 6 6Cu, 7 7mSe, 8 6mRb, 1 08Ag, 1 10Ag, 1 22mSb, 1 61Gd, 1 65m

Estudi comparatiu entre un sistema de climatització solar amb planta d’absorció geotèrmica i un sistema de climatització amb bomba de calor geotèrmica

OpenAIRE

Costillo Javier, Sergi

2009-01-01

Disseny i dimensionat d’una instal•lació de climatització, durant tot l'any, i comparació entre un sistema de climatització solar amb una planta d’absorció geotèrmica i un sistema de climatització mitjançant una bomba de calor geotèrmica, per al despatx de professors i becaris del nou laboratori d’ energia de l’EPS, mitjançant la utilització d’un sistema d’energia solar tèrmica de baixa temperatura, com a medi d’aportació de calor, i per energia geotèrmica per a la climatització integral...

A simulated RTM process for fabricating polyimide (AMB-21) carbon fiber composites

Science.gov (United States)

Avva, V. Sarma; Sadler, Robert L.; Thomas, Shanon

1995-01-01

An experimental polyimide matrix, AMB-21 - supplied by NASA/LeRC, was especially formulated to be non-carcinogenic. It was also expected to be amenable to a Resin Transfer Molding Process (RTM). AMB-21 is a solid at room temperature and must be heated to a very high temperature to obtain a fluid state. However, even after heating it to a realistic high temperature, it was found to be too viscous for use in a RTM process. As a result, a promising approach was experimented leading to the introduction of the resin into a solvent solution in order to obtain a viscosity suitable for RTM. A mixture of methanol and tetrahydroferone was found to be a suitable solvent mixture. The matrix solution was introduced into carbon-fiber preform using two techniques: (1) injection of matrix into a Resin Transfer Mold after positioning the preform into the 'mold cavity', and (2) infiltration of matrix into the preform using the 'autoclave through-the-thickness transfer process'. After completing the resin transfer (infiltration) process, the 'filled' preform was heated to 300 F for one hour to reduce the solvent content. The temperature was then increased to 400 F under a vacuum to complete the solvent evaporation and to remove volatile products of the polyimide imidization. The impregnated preform was removed from the mold and press-cured at 200 psi and 600 FF for two hours. The resulting panel was found to be of reasonably good quality. This observation was based on the results obtained from short beam shear strength (700-8000 psi) tests and microscopic examination of the cross-section indicating a very low level of porosity. Further, the flash around the molded panels from the compression molding was free of porosity indicating the removal of volatiles, solvents, and other imidization products. Based on these studies, a new RTM mold containing a diaphragm capable of applying 200 psi at 600 F has been designed and constructed with the expectation that it will allow the

Els nous reptes del transport amb autocar a Catalunya: guanyar clientela al vehicle privat

OpenAIRE

Herrán Sánchez, Lluís

1992-01-01

Les empreses catalanes de transport col·lectiu amb autocar s'enfronten als canvis que comporta la integració en el nou mercat europeu, canvis que vindran més per l'adaptació a un mercat en creixement i cada cop més exigent, que no pas per la competència que pugui representar l'entrada d'empreses estrangeres. Oferir serveis de qualitat, tecnificar la gestió empresarial i guanyar clientela al competidor immediat, el vehicle privat, són els principals reptes que ha de superar el sector.

Characterization of neutron spectra using sources of {sup 241}AmBe, {sup 238}PuBe e {sup 252}Cf moderated in water; Caracterização de espectros neutrônicos com fontes de {sup 241}AmBe, {sup 238}PuBe e {sup 252}Cf moderados em água

Energy Technology Data Exchange (ETDEWEB)

Gonçalves, A.S.; Silva, F.S.; Patrão, K.C.S.; Fonseca, E.S. da; Pereira, W.W., E-mail: angela.souzagon@gmail.com [Instituto de Radioproteção e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Laboratório de Metrologia de Nêutrons

2017-07-01

Recent studies have demonstrated the importance of characterizing the spectrum of neutron sources for various energies in order to make the understanding of neutron interaction closer to reality they work with. This work presents the determination of neutron energy flux from the source of {sup 241}AmBe (0.6 TBq), {sup 238}PuBe (1.8 TBq) and {sup 252}Cf (120 μg) free in the air and inserted into spheres of various diameters containing distilled water. The determination of the spectrum is based on the measurement and simulation by the Monte Carlo computational method, using the sources under study, with the Bonner multisphere spectrometer containing readings with the detector without sphere and covered with polyethylene balls of diameters: 5,08 cm (2 ″), 7.62 cm (3″), 12.70 cm (5 ″), 20.32 cm (8 ″), 25.40 cm (10 ″) and 30.48 cm (12 ″). It is sought to characterize a new moderate spectrum in water using the sources of {sup 241}AmBe, {sup 238}PuBe and {sup 252}Cf that may be useful for testing, calibration and irradiation of individual and area monitors for neutrons.

Imatge o text? El poder de captar l'atenció visual dels elements gràfics analitzat amb el Eye tracker

Directory of Open Access Journals (Sweden)

Elena Añaños Carrasco

2013-07-01

Full Text Available S'analitzen, amb la tecnologia Eye Tracking, els efectes de l'atenció visual dispensada sobre el text, l'element gràfic més visual de l'estímul publicitari gràfic, provocats per la incorporació d'una imatge en un estímul. Aquesta investigació es basa en diferents estudis que mostren que la gran aportació semàntica de la imatge fa que sigui l'element visual amb més poder de captació de l'atenció visual. Els resultats experimentals obtinguts, corroboren la hipòtesi, ja que la inserció d'una imatge a l'anunci original provoca un fort i significatiu augment de l'atenció visual sobre aquest element i un descens de la mateixa (transferència atencional sobre el text.

Figura ambígua e dislexia do desenvolvimento Ambiguous figure and developmental dyslexia

Directory of Open Access Journals (Sweden)

Lílian Braga Alonso

2008-04-01

Full Text Available OBJETIVO: Avaliar o processamento visual de figuras ambíguas em indivíduos disléxicos e compará-lo a um grupo controle leitor normal. MÉTODOS: Survey comparativo onde foram selecionados aleatoriamente 39 escolares cursando entre a primeira e a quarta série do ensino fundamental. Deste total, 26 não apresentavam dificuldade de leitura ou mau rendimento escolar e constituíram o grupo controle. As outras 13 crianças (grupo de estudo eram portadoras de Dislexia do desenvolvimento. Foram apresentadas, pela ordem, uma figura de Boring, uma figura com vasos de Rubin e uma figura pato/coelho de Jastrow. RESULTADOS: Os resultados obtidos mostram que as crianças com diagnóstico de Dislexia do desenvolvimento perceberam número menor de figuras em relação às do grupo controle. CONCLUSÃO: O exame do processamento visual de crianças com Dislexia do desenvolvimento para figuras ambíguas é alterado quando comparado ao de crianças leitoras normais.OBJECTIVE: Evaluate the visual response of children with developmental dyslexia when ambiguous figure was presented in comparison with normal readers children. METHODS: 39 children from basic school was randomly chosen. 26 were normal readers. 13 were diagnosed developmental dyslexia.Were presented the Boring figure, Rubin vessels figure and Jastrow figure. RESULTS: Participants in the clinical group with dyslexia performed marginally less well than those in the control group. CONCLUSION: The visual response of children with developmental dyslexia when ambiguous figure was presented is less well in comparison with normal readers children.

Exenatida (Bydureon®) d’administració setmanal: tractament de la diabetis mellitus tipus 2 en combinació amb: metformina, sulfonilurea, tiazolidinediona, metformina + sulfonilurea o metformina + tiazolidinediona

OpenAIRE

2014-01-01

Per tal de garantir la utilització efectiva i eficient dels medicaments amb recepta mèdica oficial del CatSalut, la qualitat i seguretat en la seva prescripció i la optimització de recursos s’ha creat el Programa d’Harmonització Farmacoterapèutica de medicaments en l’àmbit de l’atenció primària i comunitària (PHF-APC). Aquest document ha estat elaborat en el marc d’aquest Programa, amb el suport tècnic de l’Agència de Qualitat i Avaluació Sanitàries de Catalunya.

Pretractament amb hidròlisi parcial de residus lignocel·lulòsics

OpenAIRE

González i Anadón, Glòria

1985-01-01

Aquest resum recull el treball realitzat sobre la hidròlisi àcida de la fracció hemicel?lulòsica de residus agrícoles, com un pretractament de la cel?lulosa present, cara a la hidròlisi enzimàtica. S'ha treballat amb palla de blat, a la qual s'ha sotmès a un procés de mòlta i garbellat a fi d'aconseguir un substrat el més homogeni possible. Un cop seleccionades les variables d'operació, s'han dut a terme experiències a diferents concentracions d'àcid sulfíric i diverses tem...

Gestió de factures electròniques amb .NET (Visual Studio Tools for Office)

OpenAIRE

Gimeno Capín, Pablo

2008-01-01

Creació d¿un software de gestió de factures electròniques desenvolupat en aquesta plataforma tecnològica, amb indicació expressa d¿utilització de les eines VSTO (Visual Studio Tools for Office) en la seva última versió. Creación de un software de gestión de facturas electrónicas desarrollado en esta plataforma tecnológica, con indicación expresa de utilización de las herramientas VSTO (Visual Studio Tools for Office) en su última versión. Creation of electronic invoice management softwa...

El clima social de l'aula entre els alumnes repetidors amb els seus companys a través de Agent SocialMetric

Directory of Open Access Journals (Sweden)

Antonieta Kuz

2015-12-01

Full Text Available En aquest article descriurem una plataforma computacional web, anomenada Agent SocialMetric que simplifica al docent l'obtenció, gestió i mostra del clima de l'aula donat pel grau i estructura de les relacions dels alumnes a la classe, a través d'un agent d'interfície conversacional anomenat Albert, amb el qual el docent interactua en llenguatge natural. Agent SocialMetric possibilitarà que els docents coneguin els alumnes a través de les seves relacions reticulars, establint l'estructura social de la classe. Circumscriurem l'aplicació a un cas pràctic en l'àmbit d'Educació Secundària i coneixerem el clima social de la classe on hi ha alumnes repetidors i determinarem si aquests estan integrats amb aquells que no ho són.

Frequency domain indirect identification of AMB rotor systems based on fictitious proportional feedback gain

Energy Technology Data Exchange (ETDEWEB)

Ahn, Hyeong Joon [Dept. of Mechanical Engineering, Soongsil University, Seoul (Korea, Republic of); Kim, Chan Jung [Dept. of Mechanical Design Engineering, Pukyong National University, Busan(Korea, Republic of)

2016-12-15

It is very difficult to directly identify an unstable system with uncertain dynamics from frequency domain input-output data. Hence, in these cases, closed-loop frequency responses calculated using a fictitious feedback could be more identifiable than open-loop data. This paper presents a frequency domain indirect identification of AMB rotor systems based on a Fictitious proportional feedback gain (FPFG). The closed-loop effect due to the FPFG can enhance the detectability of the system by moving the system poles, and significantly weigh the target mode in the frequency domain. The effectiveness of the proposed identification method was verified through the frequency domain identification of active magnetic bearing rotor systems.

Disseny de calefacció amb terra radiant d'una casa a l'horta de Lleida mitjançant energia geotèrmica

OpenAIRE

Fillat Sobrino, Jordi

2008-01-01

S'ha realitzat el disseny de calefacció d'una vivenda mitjançant energia geotèrmica de baixa temperatura, amb un bescanviador vertical de 80 m de profunditat. El sistema de calefacció és de terra radiant en forma d'espiral.

Anàlisi de la resposta als tractaments combinats amb cisplatí en el càncer d'ovari: Factors implicats en la quimioresistència

OpenAIRE

Mir Cantos, Roser

2012-01-01

[cat] El càncer d’ovari (CaOV) és el quart càncer ginecològic més comú després del càncer de mama, endometri i cèrvix i representa la cinquena causa de mort per càncer en la població femenina. El CaOV epitelial (EOC) representa el 90% de tots els tumors ovàrics i és el més letal, amb una mort anual mundial de 115.000 dones, aproximadament. La majoria de les pacients amb CaOV es diagnostiquen quan la malaltia està molt avançada. El tractament es basa en citorreducció quirúrgica seguit de quimi...

Suport d’escultura amb decoració vegetal procedent del forum de Mago (Maó, Menorca)

OpenAIRE

Gómez Pons, Mireia; Garrido Elena, Anna

2013-01-01

L’any 2007 es va trobar. en unes excavacions d’urgència a Maó, una peça reutilitzada com a part d’una premsa d’oli o de vi, que anteriorment havia estat utilitzada com a pedestal d’una escultura que segurament devia tenir un text epigràfic que no ha arribat als nostres dies. Procediria del forum de la ciutat romana de Mago, Menorca, i a la seva part superior presenta dues motllures amb decoració vegetal que rodegen la totalitat del seu perímetre. Les característiques estilístiques i tècniques...

Condicionament d'un centre de telecomunicacions a Lleida mitjançant free-cooling amb evaporació adiabàtica i aire condicionat per pics. Anàlisi comparatiu amb energies renovables (geotèrmia i solar fotovoltaica)

OpenAIRE

Romero Ortuño, Yolanda

2014-01-01

El present treball respon a la necessitat de millorar el sistema de climatització existent d’un centre de telecomunicacions a Lleida. El centre té un consum intensiu i continuat d’energia per part de les emissores de telecomunicacions, i en canvi l’ús dels sistemes de climatització és variable en funció de les càrregues tèrmiques de cada moment. El treball presenta dos objectius, primer, estudiar la viabilitat d’un sistema de refrigeració eficient basat en free-cooling amb suport ...

50 curie Am-Be neutron source in determining impurities in various materials

International Nuclear Information System (INIS)

Rastikerdar, S.

1998-01-01

The neutrons from a 50 Curies Am-Be neutron source after being thermalized have been used to study the impurities in various materials by measuring the gamma rays emitted from the activated samples. To get good resolution two HPGe detectors, one of them suitable for low energy gamma rays as well as X-rays and the other suitable for measuring the gamma-ray energies up to 10 MeV have been used. The resolution of the detectors were measured and proved to be better than 1.8 keV for 60 Co gamma rays. During the measurements the detectors were placed in thick lead chambers. In these chambers the background was reduced dramatically. To make the whole system safe and also for saving time in activation analysis a fully computerized control rabbit device has been coupled to the system. Our main purpose is to set up a portable, cheap and reliable system for activation analysis for research institutions that are not able to have reactors due to various reasons. Although our tests and analysis is still in progress we think that the system is very promising. In this paper we will discuss about the details and the future prospects. (author)

Millora de l’eficiència energètica d’un edifici mitjançant energia solar fotovoltaica i aerotèrmica. Comparativa amb l’energia solar tèrmica

OpenAIRE

Casellas Sanz, Lluís

2014-01-01

Aquest projecte pretén realitzar un anàlisi de l’impacte que suposa la implantació d’una instal·lació fotovoltaica conjuntament amb una bomba de calor aerotèrmica sobre la qualificació energètica d’un habitatge. Per això, es dissenya una solució que combina les dues tecnologies esmentades (fotovoltaica i aerotèrmica) i posteriorment es compara amb el cas estàndard homòleg, que és l’energia solar tèrmica. En primer lloc es realitza l’avaluació energètica de l’habitatge en qüestió, on es car...

Monte Carlo study of a flexible device for in situ PGNAA using 241Am-Be source: application to total chlorine determination

International Nuclear Information System (INIS)

Khelifi, R.; Bode, P.

2016-01-01

MCNP5 has been used to optimize the design of a Prompt gamma ray neutron activation analysis (PGNAA) facility, which was subsequently constructed for quantification of total chlorine in water to simulate neutron transport from an 241 AmBe source into a PGNAA set-up. Modeling calculations were performed to optimize the experimental set-up for Cl measurements in water. The optimization with MCNP5 was focused on maximizing the thermal neutrons flux which leads to improving the gamma prompt production after neutron capture in a water sample. The influence of dimensions and materials for the neutron collimation as well as the dimensions of the sample together were studied. A PGNAA facility with an 241 AmBe neutron source was built based on the optimized configuration and used to determine chlorine concentration. Measured values of the chlorine count rate were plotted versus the NaCl in water. The count rate versus amount of chlorine show a good coefficient of correlation of the linear fit. The result permits PGNAA to be a valuable diagnostic tool for getting an indication of the salinity contamination of water. (author)

Models for dynamic analysis of backup ball bearings of an AMB-system

Science.gov (United States)

Halminen, Oskari; Aceituno, Javier F.; Escalona, José L.; Sopanen, Jussi; Mikkola, Aki

2017-10-01

Two detailed models of backup bearing are introduced for dynamic analysis of the dropdown event of a rotor supported by an active magnetic bearing (AMB). The proposed two-dimensional models of the backup bearings are based on a multibody approach. All parts of the bearing are modeled as rigid bodies with geometrical surfaces and the bodies interact with each other through contact forces. The first model describes a backup bearing without a cage, and the second model describes a backup bearing with a cage. The introduced models, which incorporate a realistic elastic contact model, are compared with previously presented simplified models through parametric study. In order to ensure the durability of backup bearings in challenging applications where ball bearings with an oversized bore are necessary, analysis of the forces affecting the bearing's cage and balls is required, and the models introduced in this work assist in this task as they enable optimal properties for the bearing's cage and balls to be found.

The k0-NAA Standardization Method Using an Am-Be Neutron Source

International Nuclear Information System (INIS)

Soliman, N.F.; Mohamed, G.Y.; Hassan, M.F.; Ali, M.A.

2012-01-01

Instrumental neutron activation analysis is a well established technique for the analysis of trace elements in different samples. Precise elemental concentrations of Al, Mn, Mg and Na in two unknown geological samples were determined by using the k 0 -standardization method. For such measurements two sets of standard monitors of Gold (Au), Indium (In), Tungsten (W) and Titanium (Ta) were used. One set is bare and the other is cadmium covered. These monitors were used for measuring the irradiation position factors f and α and using the cadmium ratios of the 115 In(n,γ) 116 In and 182 Ta(n,γ) 183 Ta interactions. Neutrons were obtained from CNIF 2 facility that uses an Am-Be radio-isotopic neutron source with a modification to have thermal and epi-thermal neutrons. Measurements were carried out using a gamma-ray spectrometer consisting of a hyper pure germanium detector and necessary associated electronics. The k 0 -standardization method can be used for quality control tests.

Simulació d'un tir parabòlic amb un applet de física

OpenAIRE

Fàbregas Cuadrada, Josep Manel

2016-01-01

Aquest projecte té un vessant clarament pedagògica, en un intent d'apropar l'ensenyament a l'aula a partir de la informàtica en les seves infinites aplicacions. En particular l'assignatura que es pretén portar a l'aula des de la informàtica és la Física. I de forma més concreta un tema anomenat cinemàtica, i amb més precisió el 'tir parabòlic'. L'objectiu principal ha estat crear un applet de simulació d'un tir parabòlic, per tal de poder ser observat i descrit a classe. I per facilitar als a...

Determination of vanadium, manganese and tungsten in steels with an 241 Am-Be isotopic neutron source

International Nuclear Information System (INIS)

Galdino, S.M.L.

1985-09-01

A non-destructive neutron activation method was developed for determination of vanadium, manganese, and tungsten in alloy-steel, with the aid of an Am-Be 1,85x10 11 Bq(5Ci) isotopic neutron source, employing NaI (T1) detector well type 2x2 in. The 51 V (n,γ) 52 V, 55 Mn (n,γ) 56 Mn, and 186 W (n,γ) 187 W nuclear reactions are induced in steel samples subject to activation by thermal neutron. After irradiation, the activity of the samples was measured by γ-spectrometry under the 1434 KeV 52 V, 847KeV 56 Mn, and 686 KeV 187 W photopeaks. Possible interferences due to other radionuclides activity were investigated by determining the 52 V, 56 Mn, and 187 W half-lifes. The time of analysis for vanadium determination was 11 min, with 1,5% of precision and 3,4% of average absolute deviation. The time of analysis for manganese determination was 22,8 min with 4,0% of precision and 3,4% of average absolute deviation. The time of analysis for tungsten determination was 44,62 min with 3,8% of precision and 3,1% of average absolute deviation. The activation analysis method is adequated for steel quality control in industry. (Author) [pt

Determination of the hydrogen content of oil samples from Nigeria using an Am-Be neutron source

International Nuclear Information System (INIS)

Jonah, S.A.; Elegba, S.B.; Zakari, I.I.

1998-01-01

A 5 Ci Am-Be neutron source-based facility, which utilises the principles of thermal neutron reflection technique in combination with foil activation method, has been used to determine the total hydrogen content of commercial oil samples from Nigeria. With an established detection limit of 0.25 H w% for oil matrix of volume 600-ml, the total hydrogen contents of the samples were found to be in the range of 11.11-14.22 H w%. The facility is economical and suitable for the determination of moisture in solid samples. A brief description of the ongoing projects and future plans concerning the CRP are enumerated. (author)

Design of Robust AMB Controllers for Rotors Subjected to Varying and Uncertain Seal Forces

DEFF Research Database (Denmark)

Lauridsen, Jonas Skjødt; Santos, Ilmar

2017-01-01

This paper demonstrates the design and simulation results of model based controllers for AMB systems, subjectedto uncertain and changing dynamic seal forces. Specifically, a turbocharger with a hole-pattern seal mounted acrossthe balance piston is considered. The dynamic forces of the seal, which...... are dependent on the operational conditions,have a significant effect on the overall system dynamics. Furthermore, these forces are considered uncertain.The nominal and the uncertainty representation of the seal model are established using results from conventionalmodelling approaches, i.e. CFD and Bulkflow......, and experimental results. Three controllers are synthesized: I) AnH∞ controller based on nominal plant representation, II) A µ controller, designed to be robust against uncertaintiesin the dynamic seal model and III) a Linear Parameter Varying (LPV) controller, designed to provide a unifiedperformance over a large...

Biosynthesis and the conjugation of magnetite nanoparticles with luteinizing hormone releasing hormone (LHRH)

Energy Technology Data Exchange (ETDEWEB)

Obayemi, J.D. [Department of Materials Science and Engineering, African University of Science and Technology (AUST) Abuja, Federal Capital Territory (Nigeria); Department of Materials Science and Engineering, Kwara State University, Malete, Kwara State (Nigeria); Dozie-Nwachukwu, S. [Department of Materials Science and Engineering, African University of Science and Technology (AUST) Abuja, Federal Capital Territory (Nigeria); Sheda Science and Technology Complex (SHESTCO) Abuja, Federal Capital Territory (Nigeria); Danyuo, Y. [Department of Materials Science and Engineering, African University of Science and Technology (AUST) Abuja, Federal Capital Territory (Nigeria); Department of Electronics and Electricals Engineering, Nigerian Turkish Nile University, Abuja (Nigeria); Odusanya, O.S. [Department of Materials Science and Engineering, African University of Science and Technology (AUST) Abuja, Federal Capital Territory (Nigeria); Sheda Science and Technology Complex (SHESTCO) Abuja, Federal Capital Territory (Nigeria); Anuku, N. [Department of Chemistry, Bronx Community College, New York, NY 10453 (United States); Princeton Institute of Science and Technology of Materials (PRISM), Princeton, NJ 08544 (United States); Malatesta, K. [Princeton Institute of Science and Technology of Materials (PRISM), Princeton, NJ 08544 (United States); Department of Mechanical and Aerospace Engineering, Princeton University, NJ 08544 (United States); Soboyejo, W.O., E-mail: soboyejo@princeton.edu [Department of Materials Science and Engineering, African University of Science and Technology (AUST) Abuja, Federal Capital Territory (Nigeria); Princeton Institute of Science and Technology of Materials (PRISM), Princeton, NJ 08544 (United States); Department of Mechanical and Aerospace Engineering, Princeton University, NJ 08544 (United States)

2015-01-01

This paper presents the results of an experimental study of the biosynthesis of magnetite nanoparticles (BMNPs) with particle sizes between 10 nm and 60 nm. The biocompatible magnetic nanoparticles are produced from Magnetospirillum magneticum (M.M.) bacteria that respond to magnetic fields. M.M. bacteria were cultured and used to synthesize magnetite nanoparticles. This was done in an enriched magnetic spirillum growth medium (EMSGM) at different pH levels. The nanoparticle concentrations were characterized with UV–Visible (UV–Vis) spectroscopy, while the particle shapes were elucidated via transmission electron microscopy (TEM). The structure of the particles was studied using X-ray diffraction (XRD), while the hydrodynamic radii, particle size distributions and polydispersity of the nanoparticles were characterized using dynamic light scattering (DLS). Carbodiimide reduction was also used to functionalize the BMNPs with a molecular recognition unit (luteinizing hormone releasing hormone, LHRH) that attaches specifically to receptors that are over-expressed on the surfaces of most breast cancer cell types. The resulting nanoparticles were examined using Fourier Transform Infrared (FTIR) spectroscopy and quantitative image analysis. The implications of the results are then discussed for the potential development of magnetic nanoparticles for the specific targeting and treatment of breast cancer. - Highlights: • Biosynthesis of MNPs with clinically relevant sizes between 10 and 60 nm. • New insights into the effects of pH and processing time on nanoparticle shapes and sizes. • Successful conjugation of biosynthesized magnetite nanoparticles to LHRH ligands. • Conjugated BMNPs that are monodispersed with potential biomedical relevance. • Magnetic properties of biosynthesized MNPs suggest potential for MRI enhancement.

Biosynthesis and the conjugation of magnetite nanoparticles with luteinizing hormone releasing hormone (LHRH)

International Nuclear Information System (INIS)

Obayemi, J.D.; Dozie-Nwachukwu, S.; Danyuo, Y.; Odusanya, O.S.; Anuku, N.; Malatesta, K.; Soboyejo, W.O.

2015-01-01

This paper presents the results of an experimental study of the biosynthesis of magnetite nanoparticles (BMNPs) with particle sizes between 10 nm and 60 nm. The biocompatible magnetic nanoparticles are produced from Magnetospirillum magneticum (M.M.) bacteria that respond to magnetic fields. M.M. bacteria were cultured and used to synthesize magnetite nanoparticles. This was done in an enriched magnetic spirillum growth medium (EMSGM) at different pH levels. The nanoparticle concentrations were characterized with UV–Visible (UV–Vis) spectroscopy, while the particle shapes were elucidated via transmission electron microscopy (TEM). The structure of the particles was studied using X-ray diffraction (XRD), while the hydrodynamic radii, particle size distributions and polydispersity of the nanoparticles were characterized using dynamic light scattering (DLS). Carbodiimide reduction was also used to functionalize the BMNPs with a molecular recognition unit (luteinizing hormone releasing hormone, LHRH) that attaches specifically to receptors that are over-expressed on the surfaces of most breast cancer cell types. The resulting nanoparticles were examined using Fourier Transform Infrared (FTIR) spectroscopy and quantitative image analysis. The implications of the results are then discussed for the potential development of magnetic nanoparticles for the specific targeting and treatment of breast cancer. - Highlights: • Biosynthesis of MNPs with clinically relevant sizes between 10 and 60 nm. • New insights into the effects of pH and processing time on nanoparticle shapes and sizes. • Successful conjugation of biosynthesized magnetite nanoparticles to LHRH ligands. • Conjugated BMNPs that are monodispersed with potential biomedical relevance. • Magnetic properties of biosynthesized MNPs suggest potential for MRI enhancement

Producció enantioselectiva de diols vicinals i αhidroxicetones amb oxidoreductases de llevat. Aplicació de tècniques d’autoclonació per la generación d’enzims i soques modificades

OpenAIRE

Calam Cervera, Eduard

2015-01-01

Les transformacions catalitzades per enzims s'utilitzen cada cop més per a la síntesis d'intermediaris útils destinats a les indústries farmacèutiques, agroalimentàries i de química fina. La utilització d'enzims en síntesi química compleix amb els principis de la "química verda", com per exemple en la utilització de solvents més segurs (les reaccions enzimàtiques són realitzades usualment, en medi aquós), en el disseny de reaccions amb millor eficiència energètica (les reaccions enzimàtiques ...

Application of the neutron irradiator with AmBe sources for inorganic elements in commercial fertilizers determination; Aplicacao do irradiador de neutrons com fontes de AmBe para determinacao de elementos inorganicos em fertilizantes comerciais

Energy Technology Data Exchange (ETDEWEB)

Madi Filho, Tufic; Armelin, Maria Jose Aguirre; Fulas, Paulo Marcelo Marangon [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)]. E-mail: tmfilho@ipen.br; Figueira, Rubens Cesar Lopes [Universidade Cruzeiro do Sul (UNICSUL), SP (Brazil); Trevizam, Anderson Ricardo [Centro de Energia Nuclear na Agricultura (CENA), Piracicaba, SP (Brazil)

2005-07-01

The rational use of fertilizers, for the soil fertility correction, contributes to the increase of agricultural production, using the same areas previously available. The quality of products could be improved with reduced costs. Therefore, knowledge of the chemical characteristics of the correctives used is required to streamline the application and avoid excesses or deficiencies. The studied characteristics are generally limited to the essential nutrients for the nutrition of plants and animals, e.g.: Mn, Zn, P, K, Cu and those known toxic, such as: As, Cd, Hg and Pb. Neutron activation analysis (NAA) is a highly sensitive non destructive technique, for the determination of the elemental composition in samples. It has been particularly useful in the simultaneous determination of inorganic elements in complex samples of several kinds. Several analysis methods for activation are used, such as: comparative and absolute. Commercial fertilizers were analyzed applying the absolute and comparative methods. Using the absolute method, samples were submitted to neutron flux generated by an Irradiator with two AmBe sources. The obtained results were compared with those obtained by the comparative method using neutrons generated in the IEA-R1 Reactor. (author)

Schedules of Controlled Substances: Temporary Placement of Six Synthetic Cannabinoids (5F-ADB, 5F-AMB, 5F-APINACA, ADB-FUBINACA, MDMB-CHMICA and MDMB-FUBINACA) into Schedule I. Temporary Scheduling Order.

Science.gov (United States)

2017-04-10

The Administrator of the Drug Enforcement Administration is issuing this temporary scheduling order to schedule six synthetic cannabinoids: methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate [5F-ADB; 5F-MDMB-PINACA]; methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3-methylbutanoate [5F-AMB]; N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide [5F-APINACA, 5F-AKB48]; N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide [ADB-FUBINACA]; methyl 2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate [MDMB-CHMICA, MMB-CHMINACA] and methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate [MDMB-FUBINACA], and their optical, positional, and geometric isomers, salts, and salts of isomers into schedule I pursuant to the temporary scheduling provisions of the Controlled Substances Act. This action is based on a finding by the Administrator that the placement of these synthetic cannabinoids into schedule I of the Controlled Substances Act is necessary to avoid an imminent hazard to the public safety. As a result of this order, the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances will be imposed on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis, or possess), or propose to handle, 5F-ADB, 5F-AMB, 5F-APINACA, ADB-FUBINACA, MDMB-CHMICA or MDMB-FUBINACA.

Recovery of 241Am/Be neutron sources, Wooster, Ohio

International Nuclear Information System (INIS)

Tompkins, J.A.; Wannigman, D.; Hatler, V.

1998-07-01

In August 1997, the Nuclear Regulatory Commission (NRC) submitted to the US Department of Energy (DOE) a partial list of licensed radioactive sealed sources to be recovered under a pilot project initiating Radioactive Source Recovery Program (RSRP) operations. The first of the pilot project recoveries was scheduled for September 1997 at Eastern Well Surveys in Wooster, Ohio, a company with five unwanted sealed sources on the NRC list. The sources were neutron emitters, each containing 241 Am/Be with activities ranging from 2.49 to 3.0 Ci. A prior radiological survey had established that one of these sources, a Gulf Nuclear Model 71-1 containing 3 Ci of 241 Am, was contaminated with 241 Am and might be leaking. The other four sources were obsolete and could no longer be used by Eastern Well Surveys for their intended application in well-logging applications due to NRC decertification of these sources. All of the sources exceeded the limits established for Class C waste under 10 CFR 61.55 and, as a result, are the ultimate responsibility of the DOE under the provisions of PL 99-240. This report describes the cooperative effort between the DOE and NRC to recover the sources and transport them to Los Alamos National Laboratory (LANL) for deactivation under the RSRP. This operation alleviated any potential risk to the public health and safety from the site which might result from the leaking neutron sources or the potential mismanagement of unwanted sources. The on-site recovery occurred on September 23, 1997, and was performed by personnel from LANL and its contractor and was observed by staff from the Region III office of the NRC. All aspects of the recovery were successfully accomplished, and the sources were received at LANL on September 29, 1997. Experience gained during this operation will be used to formulate operational poilicies and procedures which will contribute to the eventual routine recovery operations of a full-scale RSRP

Estudi preliminar d’expansió d’àrids reciclats estabilitzats amb ciment per a capes de base i subbase de carreteres

OpenAIRE

Forte Genescà, Marc

2012-01-01

[ANGLÈS] Aiming to promote the use of the mixed granular materials obtained from the enhanced CDW processed in recycling plants, it is studied, in a preliminary way, the properties and characteristics of these and their behavior when treated with normal Portland cement. It is also studied the effect of contamination by sulfates in the volumetric stability of these products (recycled aggregates stabilized with cement) for use as a base and sub-base’s roads. [CATALÀ] Amb l’object...

Metabolism of the synthetic cannabinoids AMB-CHMICA and 5C-AKB48 in pooled human hepatocytes and rat hepatocytes analyzed by UHPLC-(IMS)-HR-MSE.

Science.gov (United States)

Mardal, Marie; Dalsgaard, Petur Weihe; Qi, Bing; Mollerup, Christian Brinch; Annaert, Pieter; Linnet, Kristian

2018-04-15

The main analytical targets of synthetic cannabinoids are often metabolites. With the high number of new psychoactive substances entering the market, suitable workflows are needed for analytical target identification in biological samples. The aims of this study were to identify the main metabolites of the synthetic cannabinoids, AMB-CHMICA and 5C-AKB48, using an in silico-assisted workflow with analytical data acquired using ultra-high-performance liquid chromatography-(ion mobility spectroscopy)-high resolution-mass spectrometry in data-independent acquisition mode (UHPLC-(IMS)-HR-MS E ). The metabolites were identified after incubation with rat and pooled human hepatocytes using UHPLC-HR-MS E , followed by UHPLC-IMS-HR-MS E . Metabolites of AMB-CHMICA and 5C-AKB48 were predicted with Meteor (Lhasa Ltd) and imported to the UNIFI software (Waters). The predicted metabolites were assigned to analytical components supported by the UNIFI in silico fragmentation tool. The main metabolic pathway of AMB-CHMICA was O-demethylation and hydroxylation of the methylhexyl moiety. For 5C-AKB48, the main metabolic pathways were hydroxylation(s) of the adamantyl moiety and oxidative dechlorination with subsequent oxidation to the ω-COOH. The matrix components in the metabolite spectra were reduced with IMS, which improved the accuracy of the spectral interpretation; however, this left fewer fragment ions for assigning sites of metabolism. Meteor was able to predict the majority of the metabolites, with the most notable exception being the oxidative dechlorination and, consequently, all metabolites that underwent that transformation pathway. Oxidative dechlorination of ω-chloroalkanes in humans has not been previously reported in the literature. The postulated metabolites can be used for screening of biological samples, with four-dimensional identification based on retention time, collision cross section, precursor ion, and fragment ions. Copyright © 2018 Elsevier B.V. All

Characterization of neutron flux spectra in the irradiation sites of a 37 GBq {sup 241}Am-Be isotopic source

Energy Technology Data Exchange (ETDEWEB)

Yücel, Haluk [Ankara University, Institute of Nuclear Sciences, 06100 Tandogan, Ankara (Turkey); Budak, Mustafa Guray, E-mail: mbudak@gazi.edu.tr [Gazi University, Gazi Education Faculty, 06500 Teknikokullar, Ankara (Turkey); Karadag, Mustafa [Gazi University, Gazi Education Faculty, 06500 Teknikokullar, Ankara (Turkey); Yüksel, Alptuğ Özer [Ankara University, Institute of Nuclear Sciences, 06100 Tandogan, Ankara (Turkey)

2014-11-01

Highlights: • An irradiation unit was installed using a 37 GBq {sup 241}Am-Be neutron source. • The source neutrons moderated by using both water and paraffin. • Irradiation unit was shielded by boron oxide and lead against neutrons and gammas. • There are two sites for irradiations, one of them has a pneumatic transfer system. • Cadmium ratio method was used for irradiation site characterization. - Abstract: For the applicability of instrumental neutron activation analysis (NAA) technique, an irradiation unit with a 37 GBq {sup 241}Am-Be neutron source was installed at Institute of Nuclear Sciences of Ankara University. Design and configuration properties of the irradiation unit are described. It has two different sample irradiation positions, one is called site #1 having a pneumatic sample transfer system and the other is site #2 having a location for manual use. In order to characterize neutron flux spectra in the irradiation sites, the measurement results were obtained for thermal (φ{sub th}) and epithermal neutron fluxes (φ{sub epi}), thermal to epithermal flux ratio (f) and epithermal spectrum shaping factors (α) by employing cadmium ratios of gold (Au) and molybdenum (Mo) monitors. The activities produced in these foils were measured by using a p-type, 44.8% relative efficiency HPGe well detector. For the measured γ-rays, self-absorption and true coincidence summing effects were taken into account. Additionally, thermal neutron self-shielding and resonance neutron self-shielding effects were taken into account in the measured results. For characterization of site #1, the required parameters were found to be φ{sub th} = (2.11 ± 0.05) × 10{sup 3} n cm{sup −2} s{sup −1}, φ{sub epi} = (3.32 ± 0.17) × 10{sup 1} n cm{sup −2} s{sup −1}, f = 63.6 ± 1.5, α = 0.045 ± 0.009, respectively. Similarly, those parameters were measured in site #2 as φ{sub th} = (1.49 ± 0.04) × 10{sup 3} n cm{sup −2} s{sup −1}, φ{sub epi} = (2.93 ± 0

Trets comuns de les start up amb èxit a Catalunya

Directory of Open Access Journals (Sweden)

Montserrat Casanovas

2014-12-01

Full Text Available Objecte: El treball que presentem en aquest document és la primera part d’una investigació realitzada per el Grup de Treball de la Comissió de Valoració d’Empreses de l’ACCID, que té com a objectiu analitzar els factors d’èxit de les empreses de nova creació. En concret en aquest primera part del treball hem analitzat els factors financers que defineixen l’èxit de les empreses que han estat creades a Catalunya en els últims cinc anys. Disseny/metodologia: Per la realització de l’estudi s’han analitzat determinats ratis financers de les empreses que han estat creades a Catalunya en els últims cinc anys. Les dades s’han obtingut a partir de la base de dades SABI. El període de referència han estat el 2010-2012. Aportacions i resultats: Els resultats obtinguts mostren que el sector on hi ha un major nombre d’empreses amb èxit és el de comerç tan a l’ engròs com al detall. Però el que mostra uns millors ratis financers és el sector sanitari. Valor afegit: Determinar quins son els factors d’èxit de les empreses de nova creació catalanes.

Bioinspired synthesis of magnetic nanoparticles

Energy Technology Data Exchange (ETDEWEB)

David, Anand [Iowa State Univ., Ames, IA (United States)

2009-01-01

The synthesis of magnetic nanoparticles has long been an area of active research. Magnetic nanoparticles can be used in a wide variety of applications such as magnetic inks, magnetic memory devices, drug delivery, magnetic resonance imaging (MRI) contrast agents, and pathogen detection in foods. In applications such as MRI, particle uniformity is particularly crucial, as is the magnetic response of the particles. Uniform magnetic particles with good magnetic properties are therefore required. One particularly effective technique for synthesizing nanoparticles involves biomineralization, which is a naturally occurring process that can produce highly complex nanostructures. Also, the technique involves mild conditions (ambient temperature and close to neutral pH) that make this approach suitable for a wide variety of materials. The term 'bioinspired' is important because biomineralization research is inspired by the naturally occurring process, which occurs in certain microorganisms called 'magnetotactic bacteria'. Magnetotactic bacteria use biomineralization proteins to produce magnetite crystals having very good uniformity in size and morphology. The bacteria use these magnetic particles to navigate according to external magnetic fields. Because these bacteria synthesize high quality crystals, research has focused on imitating aspects of this biomineralization in vitro. In particular, a biomineralization iron-binding protein found in a certain species of magnetotactic bacteria, magnetospirillum magneticum, AMB-1, has been extracted and used for in vitro magnetite synthesis; Pluronic F127 gel was used to increase the viscosity of the reaction medium to better mimic the conditions in the bacteria. It was shown that the biomineralization protein mms6 was able to facilitate uniform magnetite synthesis. In addition, a similar biomineralization process using mms6 and a shorter version of this protein, C25, has been used to synthesize cobalt ferrite

Methodology for Quantitative Analysis of Large Liquid Samples with Prompt Gamma Neutron Activation Analysis using Am-Be Source

International Nuclear Information System (INIS)

Idiri, Z.; Mazrou, H.; Beddek, S.; Amokrane, A.

2009-01-01

An optimized set-up for prompt gamma neutron activation analysis (PGNAA) with Am-Be source is described and used for large liquid samples analysis. A methodology for quantitative analysis is proposed: it consists on normalizing the prompt gamma count rates with thermal neutron flux measurements carried out with He-3 detector and gamma attenuation factors calculated using MCNP-5. The relative and absolute methods are considered. This methodology is then applied to the determination of cadmium in industrial phosphoric acid. The same sample is then analyzed by inductively coupled plasma (ICP) method. Our results are in good agreement with those obtained with ICP method.

Com es conformen les relacions cosmopolites amb els refugiats a l’àmbit pedagògic a Finlàndia?

OpenAIRE

Medina Ponce, Míriam

2017-01-01

Aquesta investigació intenta donar resposta, de d’una sociologia interpretativa, a com es conformen les relacions cosmopolites amb els refugiats a l’àmbit educatiu a Finlàndia tal com les entén U. Beck. La utilització de tècniques qualitatives (entrevistes i observació participant) esdevenen eines clau per respondre a les qüestions plantejades durant la investigació. En aquest món cada cop més globalitzat, on tots ens trobem interconnectats, les relacions cosmopolites esdevenen el resultat d’...

La Pet amb 11c-metionina com a factor pronòstic i en la caracterització dels gliomes

OpenAIRE

Mestre i Fusco, Antoni

2015-01-01

Antecedents: La PET amb metionina és una eina de diagnòstic per la imatge útil per al diagnòstic i seguiment de tumors cerebrals. S'ha descrit la seva utilitat en la valoració de l'agressivitat tumoral tant per a la gradació tumoral com per a la valoració de la proliferació cel·lular en gliomes. No obstant hi ha poca evidència de la PET com a factor pronòstic, especialment en estudis multivariants, i per a la caracterització immunohistoquímica o molecular en gliomes. Els objectius del treball...

Disseny didàctic amb ús intencionat de TIC per potenciar l'aprenentatge dels estudiants d'embriohistología

OpenAIRE

Reyes Hernández, Héctor Félix; González Wong, Yurnet

2014-01-01

Aquest article tracta de la implementació d’un disseny didàctic amb ús intencionat de TIC com a conseqüència de la importància que ha adquirit a l’actualitat, i en particular en el context de l’educació superior. La perspectiva és potenciar la docència i l’aprenentatge en estudiants universitaris, atès que la nostra experiència docent ens demostra que no sempre s’utilitza el recurs TIC en un disseny didàtic adequat. Aquest estudi va tenir com a objectiu avaluar l’efectivitat de l’aplicació a ...

Application of the neutron irradiator with AmBe sources for inorganic elements in commercial fertilizers determination

International Nuclear Information System (INIS)

Madi Filho, Tufic; Armelin, Maria Jose Aguirre; Fulas, Paulo Marcelo Marangon; Figueira, Rubens Cesar Lopes; Trevizam, Anderson Ricardo

2005-01-01

The rational use of fertilizers, for the soil fertility correction, contributes to the increase of agricultural production, using the same areas previously available. The quality of products could be improved with reduced costs. Therefore, knowledge of the chemical characteristics of the correctives used is required to streamline the application and avoid excesses or deficiencies. The studied characteristics are generally limited to the essential nutrients for the nutrition of plants and animals, e.g.: Mn, Zn, P, K, Cu and those known toxic, such as: As, Cd, Hg and Pb. Neutron activation analysis (NAA) is a highly sensitive non destructive technique, for the determination of the elemental composition in samples. It has been particularly useful in the simultaneous determination of inorganic elements in complex samples of several kinds. Several analysis methods for activation are used, such as: comparative and absolute. Commercial fertilizers were analyzed applying the absolute and comparative methods. Using the absolute method, samples were submitted to neutron flux generated by an Irradiator with two AmBe sources. The obtained results were compared with those obtained by the comparative method using neutrons generated in the IEA-R1 Reactor. (author)

A cytogenetic study on persons exposed to 241Am-Be neutron source

International Nuclear Information System (INIS)

Bai Yushu; Zhang Xiuxia; Guan Shurong; Xie Feng; Lu Meiying

1988-01-01

An 241 Am-Be neutron source of 120 millicrocurie was stolen by a boy on April the 3rd, 1982. He brought it to his home. The neutron source was broken and the radioactive substance contaminated the whole family. He and his other family members did not leave the contaminated environment for 70 days. There were altogether 14 persons exposed to the radioactive substances. Chromosome aberrations of peripheral blood lymphocytes of six exposed cases were analysed on an early day of June 1982. The exposure doses were estimated by the frequency of chromosome aberration. Biological dose absorbed by the boy who stole the source was about 96 ∼ 128 mGy (physical dose about 120 mGy), the others were about 10 ∼ 30 mGy (physical dose about 10 ∼ 30 mGy). The results indicated that biological dose were quite approximate to the physical doses. One and half years after the accident, the analysis of stable chromosome aberrations for 14 exposed persons showed that the frequencies of chromosome aberrations of the irradiated individuals were still higher than those of the controls. The differences between them are very significant

Collimator duct for neutron radiographs using a source of 241Am-Be

International Nuclear Information System (INIS)

Oliveira, K.A.M. de; Crispim, V.R.; Silva, A.X.

2009-01-01

With the aim of designing a collimator system to realize Neutron Radiographs using source of 241 Am-Be, a collimator was designed using two removable modules. One parameter of merit to be considered in the building of a collimator is the intensity of the neutron beam on the image plane. Therefore, the choice of the inner coating material is of utmost importance. As the scattered neutrons can reduce the resolution of the neutron radiographic image, it would be opportune to capture them so that the neutron beam is aligned. Thus, an aligning module made of an absorbent material was designed, to coat the wall end extensions of the collimator. Two other parameters are essential to configure a collimator system: the length, L, and diameter of the opening, D. Geometric resolution of the neutron radiographic image is defined by the ratio L/D, as well as the neutron flux on the image plane. Simulations with code MCNP-4B were conducted to select the geometry of the collimator, the materials for the structure and coating and the dimensions for the L and D parameters and aluminum was chosen as the structural material and cadmium for coating. (author)

Neutron Fluence Evaluation using an Am-Be Neutron Sources Assembly and P ADC Detectors

International Nuclear Information System (INIS)

Seddik, U.

2008-01-01

An assembly of four 241 Am-Be sources has been constructed at Nuclear Reactions Unit (NRU) of Nuclear Research Center (NRU) to perform analysis of different materials using thermal and fast neutrons. In the present paper, we measure the value of transmittance (T) in percentage of etched CR-39 detectors using a spectrophotometer at different neutron fluences ,to relate the transmittance of the detector with the neutron fluence values. The exposed samples to neutrons with accumulated fluence of order between 10 10 and 10 12 cm -2 were etched for 15 time intervals between 10-600 min in 6.25 N NaOH at 70 degree C. The etched samples were analyzed using Tech 8500 II spectrophotometer. A trend of the sample transmission and the etching time is observed which is different for each fluence value. A linear relation between the transmittance decay constant and the neutron fluence is observed which could be used as a calibration to determine unknown neutron fluence

Interference with effects of amphotericin B on Candida albicans cells by 2-chloroethyl-1-nitrosoureas.

OpenAIRE

Brajtburg, J; Elberg, S; Kobayashi, G S; Medoff, G

1988-01-01

Two nitrosoureas, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU), with strong carbamoylating and weak alkylating activities, interfered with the induction of potassium leakage and lethal action of amphotericin B (AmB) on Candida albicans. 2-Cyclohexyl isocyanate, the product of decomposition of CCNU, and 2-chloroethyl isocyanate, the product of decomposition of BCNU, also interfered with the anticandidal actions of AmB. In contrast, two ni...

Measurement of the removal sechtion of biological protection concretes in the spectrum of an AmBe source

International Nuclear Information System (INIS)

Sandin, C.; Tenrreiro, J.; Desdin, L.; Sarria, P.; Monne, G.; Tellez, E.; Csikai, J

1992-01-01

A method to measure the neutron removal cross sections in cuban concrete for biological protection using the average spectrum of a radioisotopic source was developed. The method was verified by the measurements of different materials with know removal cross sections like Pb, paraffin and water. These spetial cuban concrete are elaborated on the basis of arids of limestone, limonite, magnetite, baryte and serpentine. The aim of this work is to contribute to the characterization of those concretes for its use in cuban nuclear installations. In the experiments were used an AmBe source with an strength of 10 6 n/s. and a long counter detector with associated electronics. It can be seen in the table that the concretes of magnetite and limonite have the best shielding properties for neutrons

Anàlisi teòrica dels antecedents i conseqüències de la identificació de l'alumnat amb la universitat i de la seva percepció de qualitat universitària

Directory of Open Access Journals (Sweden)

Irene Trullas

2011-04-01

Full Text Available Objecte: L'objectiu d’aquest article és desenvolupar un model conceptual centrat en els antecedents de la identificació de l'alumnat amb la universitat i la seva percepció de la qualitat universitària, perquè investigacions futures puguin provar des d’un punt de vista empíric les proposicions assenyalades.Disseny/metodologia: La metodologia consisteix en una anàlisi de la literatura empírica existent i del models teòrics actuals enfocats en el màrqueting a nivell universitari. Resultats: La identificació de l’estudiant amb la universitat i la seva percepció de qualitat de la institució són dos variables claus per a la captació i la retenció de l’alumnat. Aquest article proposa que la identificació depèn del suport institucional percebut per l'estudiant, que al seu torn està positivament relacionat amb: la comunicació corporativa, la relació universitat-alumne i la relació alumne-alumne. D’altra banda, l’ocupabilitat d’una institució educativa és relaciona positivament amb la percepció de qualitat universitària per part de l’estudiant i aquesta percepció ve determinada per la bona reputació de la universitat i per la percepció de l’estudiant que la universitat fomenta l’ocupabilitat en la seva formació. Limitacions: El model presentat es fonamenta des d’un punt de vista teòric i per tant és un punt de partida de línies futures de caràcter empíric.Implicacions pràctiques: Aquest article teòric pretén donar un punt de sortida i nou enfocament al màrqueting universitari. Esperem que aquest article ajudi a accelerar el progrés en l’àmbit del màrqueting universitari, posant de relleu qüestions fonamentals que necessiten investigació futura.Implicacions socials: La confirmació del model conceptual donaria les eines necessàries perquè les universitats desenvolupin les seves estratègies de captació i retenció d'estudiants basant-se en el màrqueting i en la segmentació, fet que

Gestió de la comunicació interactiva amb els empleats: Efectes de les senyals de presència social, personalització, i velocitat de retroalimentació

Directory of Open Access Journals (Sweden)

Xavier Armengol-Vila

2015-06-01

Full Text Available Objecte: Cada vegada més, les organitzacions estan més conscienciades que l’èxit empresarial s’aconsegueix amb el treball constant i enèrgic de tots els seus integrants. Aspectes com el compromís i la motivació son cabdals. Aquest article, fa referencia a la necessitat cada vegada més creixent d’utilitzar els canals de comunicació en línia per gestionar més eficaçment les relacions amb els empleats. Disseny/metodologia: Prenent com a base la teoria de la riquesa dels mitjans de comunicació, es fa una proposta per a examinarels factors que afecten en una comunicació eficaç, relacionant les senyals d’informació, la personalització, i la velocitat en dues situacions diferents. Aportacions i resultats: Aquest treball ofereix vuit propostes per tal d’estimular la investigació futura en els canals emergents. Limitacions: En l’estudi només es consideren dos canals de comunicació basats en internet: correu electrònic i missatgeria instantània. Implicacions pràctiques: Conèixer la percepció dels treballadors és fonamental per tal de millorar els processos comunicatius en organitzacions i institucions. Els resultats d’aquest recerca poden oferir una visió clara dels efectes de l’ús eficient de nous canals de comunicació. Implicacions socials: La capacitat dels nous dispositius mòbils amb connexió permanent online ha afavorit l’ús massiu de nous canals de comunicació. Conèixer els factors determinats que influeixen en la percepció dels usuaris sobre els nous canals, és un factor determinat en l’elecció dels mitjans de comunicació. Valor afegit: Tot i què es manifest l’ús intensiu dels nous canals de comunicació, són pocs els estudis que analitzin els efectes i repercussions del seu ús en organitzacions i institucions.

Detection and dosimetry studies on the response of silicon diodes to an 241Am-Be source

International Nuclear Information System (INIS)

Lotfi, Y; Dizaji, H Zaki; Davani, F Abbasi

2014-01-01

Silicon diode detectors show potential for the development of an active personal dosimeter for neutron and photon radiation. Photons interact with the constituents of the diode detector and produce electrons. Fast neutrons interact with the constituents of the diode detector and converter, producing recoil nuclei and causing (n,α) and (n,p) reactions. These photon- and neutron-induced charged particles contribute to the response of diode detectors. In this work, a silicon pin diode was used as a detector to produce pulses created by photon and neutron. A polyethylene fast neutron converter was used as a recoil proton source in front of the detector. The total registered photon and neutron efficiency and the partial contributions of the efficiency, due to interactions with the diode and converter, were calculated. The results show that the efficiency of the converter-diode is a function of the incident photon and neutron energy. The optimized thicknesses of the converter for neutron detection and neutron dosimetry were found to be 1 mm and 0.1 mm respectively. The neutron records caused by the (n,α) and (n,p) reactions were negligible. The photon records were strongly dependent upon the energy and the depletion layer of the diode. The photons and neutrons efficiency of the diode-based dosimeter was calculated by the MCNPX code, and the results were in good agreement with experimental results for photons and neutrons from an 241 Am-Be source

Determination of boron in water solution by an indirect neutron activation technique from a 241Am/Be source

International Nuclear Information System (INIS)

Sales, H.B.

1981-08-01

Boron content in water solutions has been analysed by Indirect Activation Technique a twin 241 Am/Be neutron source with a source strength of 9x10 6 n/seg. The boron concentration was inferred from the measurement of the activity induced in a vanadium flux monitor. The vanadium rod was located inside the boron solution in a standart geometrical set up with respect to the neutron source. Boron concentrations in the range of 100 to 1000 ppm were determined with an overall accuracy of about 2% during a total analysis time of about 20 minutes. Eventhough the analysis is not selective for boron yet due the rapid, simple and precise nature, it is proposed for the analysis of boron in the primary coolant circuit of Nuclear Power Plants of PWR type. (Author) [pt

Efectivitat de la hipoteràpia en nens amb paràlisi cerebral espàstica. Una revisió sistemàtica

OpenAIRE

Tarragó Coletas, Mariona

2017-01-01

PREGUNTA DE LA REVISIÓ. És efectiva la hipoteràpia en nens amb paràlisi cerebral espàstica? OBJETIUS. General: Revisar i avaluar l’efectivitat de la hipoteràpia en el tractament de PCI espàstica. Específics: Realitzar una recerca bibliogràfica dels beneficis que aporta la hipoteràpia com a tractament de la PCI espàstica. Avaluar si existeix una millora de la qualitat de vida utilitzant la hipoteràpia com a tractament de la PCI espàstica. Determinar com afecta el tractament sobre la funcion...

Amphotericin B induced interdigitation of apolipoprotein stabilized nanodisk bilayers

Energy Technology Data Exchange (ETDEWEB)

Nguyen, T; Weers, P M; Sulchek, T; Hoeprich, P D; Ryan, R O

2006-12-07

Amphotericin B nanodisks (AMB-ND) are ternary complexes of AMB, phospholipid (PL) and apolipoprotein organized as discrete nanometer scale disk-shaped bilayers. In gel filtration chromatography experiments, empty ND lacking AMB elute as a single population of particles with a molecular weight in the range of 200 kDa. AMB-ND formulated at a 4:1 PL:AMB weight ratio, separated into two peaks. Peak 1 eluted at the position of control ND lacking AMB while the second peak, containing all of the AMB present in the original sample, eluted in the void volume. When ND prepared with increased AMB (1:1 phospholipid:AMB molar ratio) were subjected to gel filtration chromatography, an increased proportion of phospholipid and apolipoprotein were recovered in the void volume with the AMB. Prior to gel filtration the AMB-ND sample could be passed through a 0.22 {micro}m filter without loss of AMB while the voided material was lost. Native gel electrophoresis studies corroborated the gel permeation chromatography data. Far UV circular dichroism analyses revealed that apoA-I associated with AMB-ND denatures at a lower guanidine HCl concentration than apoA-I associated with ND lacking AMB. Atomic force microscopy revealed that AMB induces compression of the ND bilayer thickness consistent with bilayer interdigitation, a phenomenon that is likely related to the ability of AMB to induce pore formation in susceptible membranes.

Schedules of Controlled Substances: Temporary Placement of Six Synthetic Cannabinoids (5F-ADB, 5F-AMB, 5F-APINACA, ADB-FUBINACA, MDMB-

Science.gov (United States)

2016-12-21

The Administrator of the Drug Enforcement Administration is issuing this notice of intent to temporarily schedule six synthetic cannabinoids: methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate [5F-ADB; 5F-MDMB-PINACA]; methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3-methylbutanoate [5F-AMB]; N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide [5F-APINACA, 5F-AKB48]; N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide [ADB-FUBINACA]; methyl 2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate [MDMB-CHMICA, MMB-CHMINACA] and methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate [MDMB-FUBINACA], into schedule I pursuant to the temporary scheduling provisions of the Controlled Substances Act (CSA). This action is based on a finding by the Administrator that the placement of these synthetic cannabinoids into schedule I of the Controlled Substances Act is necessary to avoid an imminent hazard to the public safety. Any final order will impose the administrative, civil, and criminal sanctions and regulatory controls applicable to schedule I substances under the Controlled Substances Act on the manufacture, distribution, possession, importation, exportation of, and research and conduct with, instructional activities of these synthetic cannabinoids.

Comparison between {sup 241}AmBe (α, n) sources in the calibration of survey monitors for neutrons in magnitude H⁎(10); Comparação entre fontes de {sup 241}AmBe (α,n) na calibração de monitores de área para nêutrons na grandeza H⁎(10)

Energy Technology Data Exchange (ETDEWEB)

Pereira, W.W.; Filho, C.A.L.S.; Silva, F.S.; Patrão, K.C.S., E-mail: walsanwagner@gmail.com [Instituto de Radioproteção e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Estrada, J.J.S. [Fundação Técnico Educacional Souza Marques, Rio de Janeiro, RJ (Brazil); Alves, C.F.E.; Magalhães, L.A.G.; Leite, S.P. [Universidade do Estado do Rio de Janeiro (UERJ), RJ (Brazil)

2017-07-01

Recently the Laboratório de Ciências Radiológicas (LCR / UERJ) characterized a {sup 241}AmBe (α, n) neutron source for metrological use. This source comes from the Oil Company and it was originally used in well logging tools. In this work, this source was used in the calibration of an survey meter using procedures and facilities of the Laboratório Nacional de Metrologia das Radiações Ionizantes (LN/LNMRI). The results of the calibration with the LCR neutron source agreed with those obtained when the LN/LNMRI neutron source was used. (author)

The anthraquinones rubiadin and its 1-methyl ether isolated from Heterophyllaea pustulata reduces Candida tropicalis biofilms formation.

Science.gov (United States)

Marioni, Juliana; da Silva, María Angel; Cabrera, José Luis; Montoya, Susana C Núñez; Paraje, María Gabriela

2016-11-15

Candida tropicalis is increasingly becoming among the most commonly isolated pathogens causing fungal infections with an important biofilm-forming capacity. This study addresses the antifungal effect of rubiadin (AQ1) and rubiadin 1-methyl ether (AQ2), two photosensitizing anthraquinones (AQs) isolated from Heterophyllaea pustulata, against C. tropicalis biofilms, by studying the cellular stress and antioxidant response in two experimental conditions: darkness and irradiation. The combination with Amphotericin B (AmB) was assayed to evaluate the synergic effect. Biofilms of clinical isolates and reference strain of Candida tropicalis were treated with AQs (AQ1 or AQ2) and/or AmB, and the biofilms depletion was studied by crystal violet and confocal scanning laser microscopy (CSLM). The oxidant metabolites production and the response of antioxidant defense system were also evaluated under dark and irradiation conditions, being the light a trigger for photo-activation of the AQs. The Reactive Oxygen Species (ROS) were detected by the reduction of Nitro Blue Tetrazolium test, and Reactive Nitrogen Intermediates (RNI) by the Griess assay. ROS accumulation was also detected inside biofilms by using 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA) probe, which was visualized by CSLM. Superoxide dismutase (SOD) activity and the total antioxidant capacity of biofilms were measured by spectrophotometric methods. The minimun inhibitory concentration for sessile cells (SMIC) was determined for each AQs and AmB. The fractional inhibitory concentration index (FICI) was calculated for the combinations of each AQ with AmB by the checkerboard microdilution method. Biofilm reduction of both strains was more effective with AQ1 than with AQ2. The antifungal effect was mediated by an oxidative and nitrosative stress under irradiation, with a significant accumulation of endogenous ROS detected by CSLM and an increase in the SOD activity. Thus, the prooxidant-antioxidant balance was

Tractament dietètic de la resistència a la insulina amb compostos bioactius i els seus efectes en el mitocondri

OpenAIRE

Casañé Riera, Anna

2014-01-01

La síndrome metabòlica és una epidèmia creixent a tot el món i consisteix en un conjunt de factors de risc per a la malaltia cardiovascular i diabetis tipus 2. Es caracteritza per l’obesitat central, la hiperlipidèmia, la hipertensió i la resistència a la insulina; uns factors que estan vinculats amb els canvis de l’estil de vida de la població, causats pel consum de dietes hipercalòriques i d’un estil de vida sedentari. Les primeres línies de tractament per reduir la síndrome ...

NanoDisk containing super aggregated amphotericin B: a high therapeutic index antifungal formulation with enhanced potency

Directory of Open Access Journals (Sweden)

Burgess BL

2013-12-01

Full Text Available Braydon L Burgess,1,2 Yumin He,1 Mandie M Baker,1,2 Bing Luo,2 Stephen F Carroll,2 Trudy M Forte,2 Michael N Oda11Children's Hospital Oakland Research Institute, Oakland, CA, USA; 2Lypro Biosciences, Berkeley, CA, USAObjectives: NanoDisk–amphotericin B (ND-AMB is a protein-phospholipid bioparticle containing a “super aggregate” form of antifungal AMB. While lipid-based formulations of AMB, including liposomal AMB (L-AMB, are safer than the deoxycholate (DOC solubilized form (DOC-AMB, the potency of lipid-based formulations is attenuated. We have developed an AMB-based therapy that is both well tolerated and fully efficacious.Methods: Potency was determined using broth culture growth-inhibition assays and candidacidal kinetics by quantitative culture plating. Toxicology studies were performed in healthy mice. Efficacy was assessed using both immune-competent and leukopenic murine models of systemic Candida albicans infection.Results: ND-AMB C. albicans and Aspergillus fumigatus minimum inhibitory concentrations were fourfold and sixfold lower, respectively, than that observed for L-AMB. ND-AMB exhibited candidacidal activity at 0.125 mg/L, 16-fold lower than L-AMB. In mice, ND-AMB produced no statistically significant kidney or liver toxicity at 15 mg/kg, the highest dose tested. When evaluated in immune-competent mice infected with C. albicans, ND-AMB was at least as effective as DOC-AMB or L-AMB. In a leukopenic model of candidiasis, the 50% effective dose of ND-AMB was around threefold lower than L-AMB.Conclusion: These results indicate that ND-AMB exhibits a more favorable safety profile while maintaining uncompromised antifungal properties compared to both DOC-AMB and L-AMB. ND-AMB is a promising therapy for the treatment of invasive fungal infections.Keywords: nanoparticles, infectious diseases, drug delivery, candidiasis, apolipoprotein A-I

Measurement of thermal neutron cross-sections and resonance integrals for sup 7 sup 1 Ga(n,gamma) sup 7 sup 2 Ga and sup 7 sup 5 As(n,gamma) sup 7 sup 6 As by using sup 2 sup 4 sup 1 Am-Be isotopic neutron source

CERN Document Server

Karadag, M; Tan, M; Oezmen, A

2003-01-01

Thermal neutron cross-sections and resonance integrals for the sup 7 sup 1 Ga(n,gamma) sup 7 sup 2 Ga and sup 7 sup 5 As(n,gamma) sup 7 sup 6 As reactions were measured by the activation method. The experimental samples with and without a cylindrical Cd shield case in 1 mm wall thickness were irradiated in an isotropic neutron field of the sup 2 sup 4 sup 1 Am-Be neutron source. The induced activities in the samples were measured by high-resolution gamma-ray spectrometry with a calibrated reverse-electrode germanium detector. Thermal neutron cross-sections for 2200 m/s neutrons and resonance integrals for the sup 7 sup 1 Ga(n,gamma) sup 7 sup 2 Ga and sup 7 sup 5 As(n,gamma) sup 7 sup 6 As reactions have been obtained relative to the reference values, sigma sub 0 =13.3+-0.1 b and I sub 0 =14.0+-0.3 b for the sup 5 sup 5 Mn(n,gamma) sup 5 sup 6 Mn reaction as a single comparator. The necessary correction factors for gamma attenuation, thermal neutron and resonance neutron self-shielding effects were taken into...

Performance assessment of auxiliary bearing in HTR-10 AMB helium circulator on the event of rotor drop

International Nuclear Information System (INIS)

Xiao Zhen; Yang Guojun; Li Yue; Shi Zhengang; Yu Suyuan

2014-01-01

In this paper, a model for analyzing internal contact stress arid external load of ball bearing from rotor displacement was developed based on the Hertz contact theory and applied to the analysis of the rotor drop test in HTR-10 helium circulator equipped with AMB (Active Magnetic Bearing) to gain a better understanding of auxiliary bearing performance at different stages after the rotor drop. It was shown that the auxiliary bearing can well resist axial impact produced by rotor drop, avoiding of internal severe plastic deformation and damage to the performance of the auxiliary bearing. Rotor's rotary motion and the heat accumulation of the inner ring resulted from the initial acute acceleration are the main contributor of radial load during the rotor idling and may cause the failure of auxiliary bearing. This paper analyzed the influence of this load and confirmed that the auxiliary bearing can still work in its loading limits. (authors)

Aluminium and copper analysis in metallic alloys by neutron activation analysis from an 241 Am-Be source

International Nuclear Information System (INIS)

Carvalho, J. de.

1980-01-01

Aluminium and copper have been determined in aluminium alloys by the method of activation with neutrons from an 241 Am-Be source of intensity 9,8 x 10 6 n/s. The activity induced due to reactions 27 Al (n, γ) 28 Al and 63 Cu (n, γ) 64 Cu have been measured with a NaI (Tl) detector coupled to a single channel system. In order to obtain the samples and standards of about the same composition, the material to be irradiated was powdered. In view of low intensity of neutron source it was necessary to use samples of up to 50 g. A series of preliminary irradiations were carried out to ensure that the geometry for the irradiation and for the counting are reproducible. The results have been compared with those obtained by chemical methods. Assuming that the results obtained by chemical method is exact, a maximum relative error of 3,6% is obtained by this method. The method has a good reproducibility. The time needed for analysis of aluminium and copper are 18 min and 2 hours 40 minutes respectively. Four different samples were analysed. The average of five measurements for one of the samples was: 88.0% for aluminium and 10.0% for copper. The standard deviation and coefficient of variation were 0,8 and 1.0% for aluminium and 0,2 and 2.0% for copper. (author)

Effects of VPAC1 activation in nucleus ambiguus neurons.

Science.gov (United States)

Gherghina, Florin Liviu; Tica, Andrei Adrian; Deliu, Elena; Abood, Mary E; Brailoiu, G Cristina; Brailoiu, Eugen

2017-02-15

The pituitary adenylyl cyclase-activating polypeptide (PACAP) and its G protein-coupled receptors, PAC1, VPAC1 and VPAC2 form a system involved in a variety of biological processes. Although some sympathetic stimulatory effects of this system have been reported, its central cardiovascular regulatory properties are poorly characterized. VPAC1 receptors are expressed in the nucleus ambiguus (nAmb), a key center controlling cardiac parasympathetic tone. In this study, we report that selective VPAC1 activation in rhodamine-labeled cardiac vagal preganglionic neurons of the rat nAmb produces inositol 1,4,5-trisphosphate receptor-mediated Ca 2+ mobilization, membrane depolarization and activation of P/Q-type Ca 2+ channels. In vivo, this pathway converges onto transient reduction in heart rate of conscious rats. Therefore we demonstrate a VPAC1-dependent mechanism in the central parasympathetic regulation of the heart rate, adding to the complexity of PACAP-mediated cardiovascular modulation. Copyright © 2017 Elsevier B.V. All rights reserved.

Use of CITATION code for flux calculation in neutron activation analysis with voluminous sample using an Am-Be source

International Nuclear Information System (INIS)

Khelifi, R.; Idiri, Z.; Bode, P.

2002-01-01

The CITATION code based on neutron diffusion theory was used for flux calculations inside voluminous samples in prompt gamma activation analysis with an isotopic neutron source (Am-Be). The code uses specific parameters related to the energy spectrum source and irradiation system materials (shielding, reflector). The flux distribution (thermal and fast) was calculated in the three-dimensional geometry for the system: air, polyethylene and water cuboidal sample (50x50x50 cm). Thermal flux was calculated in a series of points inside the sample. The results agreed reasonably well with observed values. The maximum thermal flux was observed at a distance of 3.2 cm while CITATION gave 3.7 cm. Beyond a depth of 7.2 cm, the thermal flux to fast flux ratio increases up to twice and allows us to optimise the detection system position in the scope of in-situ PGAA

Glycosylation of alpha(2)delta(1) subunit: a sweet talk with Ca(v)1.2 channels

Czech Academy of Sciences Publication Activity Database

Lazniewska, Joanna; Weiss, Norbert

2016-01-01

Roč. 35, č. 3 (2016), s. 239-242 ISSN 0231-5882 R&D Projects: GA ČR GA15-13556S; GA MŠk 7AMB15FR015 Institutional support: RVO:61388963 Keywords : calcium channel * Ca(v)1.2 channel * ancillary subunit * alpha(2)delta(1) subunit * glycosylation * trafficking Subject RIV: CE - Biochemistry Impact factor: 1.170, year: 2016

Estudi de l’energia geotèrmica a Catalunya i la seva implementació a l’edificació. Comparativa amb l’energia solar tèrmica

OpenAIRE

Roca Subirana, Laura

2010-01-01

Aquest projecte pretén analitzar l’estat actual de l’energia geotèrmica a Catalunya i estudiarne la seva implementació en l’edificació. A més, pretén realitzar un estudi comparatiu entre aquesta energia renovable i l’energia solar tèrmica. Primerament, es realitza un balanç sobre el consum i la producció actuals d’energia a Catalunya. Aquest balanç es complementa amb una incisió sobre l’estat actual de les energies renovables a Catalunya, com també el futur que se’ls hi depara....

Aproximació a la història de vida a partir d’un taller de formació amb l’alumnat de 1r de Grau d’Educació Social

Directory of Open Access Journals (Sweden)

Nieves Martin-Bermudez

2014-04-01

Full Text Available Els esforços realitzats per adaptar els continguts i les metodologies docents a l’Espai Europeu d‘Educació Superior (EEES s’han centrat, entre d’altres coses, en la formació per competències, l’avaluació continuada o l’aprenentatge actiu, autònom i participatiu. En concret, hem considerat l’ús del taller didàctic per afavorir la construcció del coneixement des de l’aula, facilitant la posada en pràctica de continguts teòrics. Això ens ha facilitat transformar la metodologia d’una assignatura eminentment teòrica en una altra en què l’alumnat mateix participa construint el contingut mitjançant l’inici a la investigació emprant la tècnica de la història de vida. Presentem en aquest article el procés i resultat de l’experiència amb alumnat del Grau d’Educació Social de la Universitat Pablo d’ Olavide (Sevilla durant dos cursos acadèmics. El treball posa de manifest un alt consens sobre la importància d’integrar l’ús del taller didàctic a les aules.

Com obtenir un Model de Regressió Logística Binària amb SPSS

Directory of Open Access Journals (Sweden)

Vanesa Berlanga-Silvente

2014-04-01

Full Text Available Els models de regressió logística són models estadístics en què es desitja conèixer la relació entre: una variable dependent qualitativa dicotòmica (regressió logística binària o binomial i una o més variables explicatives independents, o covariables, ja siguin qualitatives o quantitatives. També és possible una variable dependent qualitativa amb més de dos valors (regressió logística multinomial, encara que en aquesta fitxa ens centrarem en la regressió logística binària. En qualsevol cas, l'equació inicial del model és de tipus exponencial, si bé la seva transformació logarítmica (logit permet el seu ús com una funció lineal. L'objectiu primordial que resol aquesta tècnica és el de modelar com influeixen la probabilitat d'aparició d'un succés, habitualment dicotòmic, la presència o no de diversos factors, i el valor o nivell dels mateixos. Aquesta fitxa sobre la Regressió Logística Binària explica les opcions que té el programa estadístic SPSS (mètodes automàtics "per passos" i la interpretació dels principals resultats.

Effect of sample moisture and bulk density on performance of the 241Am-Be source based prompt gamma rays neutron activation analysis setup. A Monte Carlo study

International Nuclear Information System (INIS)

Almisned, Ghada

2010-01-01

Monte Carlo simulations were carried out using the dependence of gamma ray yield on the bulk density and moisture content for five different lengths of Portland cement samples in a thermal neutron capture based Prompt Gamma ray Neutron Activation Analysis (PGNAA) setup for source inside moderator geometry using an 241 Am-Be neutron source. In this study, yields of 1.94 and 6.42 MeV prompt gamma rays from calcium in the five Portland cement samples were calculated as a function of sample bulk density and moisture content. The study showed a strong dependence of the 1.94 and 6.42 MeV gamma ray yield upon the sample bulk density but a weaker dependence upon sample moisture content. For an order of magnitude increase in the sample bulk density, an order of magnitude increase in the gamma rays yield was observed, i.e., a one-to-one correspondence. In case of gamma ray yield dependence upon sample moisture content, an order of magnitude increase in the moisture content of the sample resulted in about 16-17% increase in the yield of 1.94 and 6.42 MeV gamma rays from calcium. (author)

Projecte de les instal·lacions elèctriques per a l'execució d'una obra de construcció de túnel amb màquina tuneladora

OpenAIRE

Hernández Briones, Rafael

2009-01-01

En primer terme comentar que es tracta d’un projecte real dut a la pràctica durant la meva activitat professional en una empresa constructora. El projecte defineix les instal·lacions elèctriques per a l’execució d’un túnel amb tuneladora, pertanyent a la futura Línia 9 del Metro de Barcelona. L’abast del projecte comprèn des del subministrament per part de la Companyia Elèctrica a 25 KV, el centre de recepció i mesura, l’alimentació a 20Kv de la tuneladora i resta d’instal·l...

Programa de prevenció del consum d’alcohol i altres drogues amb alumnes de secundària a la Unitat Terapèutica i Educativa del Centre Penitenciari de Villabona

OpenAIRE

Palasí Luna, Eva; Valverde Molina, Jesús; , Elisabet

2014-01-01

El consum de substàncies tòxiques per part dels joves és un fenomen social molt present. Des de l’administració pública i també des d’entitats socials i del tercer sector es duen a terme diversitat de campanyes i iniciatives orientades a la prevenció d’aquests consums amb orientacions i objectius diversos. En aquest article presentem una programa de prevenció que es desenvolupa a la Unitat Terapèutica i Educativa del Centre Penitenciari de Villabona, en el qual participen les persones interne...

Avrupa Merkez Bankası'nın (AMB Euro Yönetimindeki Etkinlik Sorununun Analizi ( Efficiency Management Problem Of European Central Bank (ECB About The Euro

Directory of Open Access Journals (Sweden)

Hüseyin ÖZDEŞER

2015-12-01

Full Text Available The necessity of a monetary integration process in the European Union is inarguable. Monetary Union has a corner stone role for letting Economy in the EU to act as a whole. Only 19 members of the EU take place in the Euro Zone. In this case; there is a long time needed for completion the monetary integration process. European Central Bank (ECB which is responsible for the monetary policy application in Euro Zone, will have serious weakness and desperation and having them is inevitable; because the economic and political integration of the EU is not completed yet. All kinds of conflicts in political and economic integration process of the EU and economic crises, will have negative impacts on the EU and also on Euro. ECB is helpless about any negative developments that take place or may take place in European Monetary Union (EMU Area and it does not have an efficient intervention chance for preventing the negative impacts occurring on the Euro. The aim of the study is to present the weakness and desperation of the ECB about applying policies for a stable Euro. Avrupa Birliği'nde (AB Parasal Birlik sürecinin gerekliliği tartışılmazdır. Parasal Birlik; ekonominin AB içerisinde bir bütünsel olarak hareketliliğinin sağlanabilmesi açısından köşe taşı niteliğindedir. AB'nde şu an için toplam 28 olan AB üyesi ülkeden yalnızca 19 üye euro bölgesinde yer almaktadır. Bu durum parasal entegrasyonun tamamlanabilmesi için uzun süreye ihtiyaç olduğunun göstergesidir. Euro bölgesinde para politikalarının uygylanmasından sorumlu olan Avrupa Merkez Bankası (AMB, AB'nin ekonomik ve siyasi entegrasyonunun tamamlanmamasından dolayı ciddi zaaflar ve çaresizlikler yaşamaktadır; ve yaşaması da kaçınılmazdır. AB ve euro bölgesinde yaşanan her türlü sayasi ve ekonomik entegrasyon süreçlerindeki çatışmalar ve aynı zamanda ekonomik krizler; AB'ni ve euroyu olumsuz etkilemektedir. Yalnızca euronun y

Optimization of shadow cone length and mass for determination the amount of scattered radiation dose in the calibration laboratory of Am/Be neutron source

International Nuclear Information System (INIS)

Raisali, G.; Hamidi, S.; Hallajfard, E.; Shahvar, A.; Hajiloo, N.

2007-01-01

The shadow cone technique is one of the methods which is used for determining the contribution of scattered particles on the response of neutron detectors. This technique is used for neutron field calibration in Agriculture, Medicine and Industry Research School. In this investigation, we have designed and constructed an optimized shadow cone. According to the calculated neutron dose equivalent attenuation factors, a cone with 20 cm of iron and 30 cm of polyethylene has been found as optimum. For this cone, the neutron dose equivalent attenuation factor for 241 Am/Be neutron source, is 0.00035 for which the contribution of scattered neutrons in Agriculture, Medicine and Industry Research School neutron calibration laboratory according to the calculation and measurement results, can be evaluated with less than 0.5% of error

Reflexions sociològiques figuratives i de procés sobre l’esport i la globalització: algunes observacions conceptuals i teòriques, amb especial referència al futbol

OpenAIRE

Dunning, Eric

2009-01-01

Aquest article es divideix en tres parts. La primera consisteix en un comentari conceptual teòric sobre la globalització i en diversos exemples del món globalitzat de l’esport; la segona és un comentari sobre el desenvolupament i l’extensió global del futbol; i la tercera exposa el comentari d’algunes patologies relacionades amb l’esport. Tot al llarg de l’article s’aplica l’enfocament sociològic figuratiu i de procés desenvolupat per Norbert Elias. En resum, aquest treball és fonamentalment ...

Enhanced antifungal effects of amphotericin B-TPGS-b-(PCL-ran-PGA nanoparticles in vitro and in vivo

Directory of Open Access Journals (Sweden)

Tang X

2014-11-01

Full Text Available Xiaolong Tang,1,2,* He Zhu,3,* Ledong Sun,4,* Wei Hou,2 Shuyu Cai,1 Rongbo Zhang,1 Feng Liu5 1Stem Cell Engineering Research Center, School of Medicine, Anhui University of Science and Technology, Huainan, People’s Republic of China; 2State Key Laboratory of Virology, Life Sciences College, Wuhan University, Wuhan, Hubei, People’s Republic of China; 3Institute of Skin Damage and Repair, General Hospital of Beijing Military Command, Beijing, People’s Republic of China; 4Department of Dermatology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 5Department of Anesthesiology, Children’s Hospital, Chongqing Medical University; Key Laboratory of Child Development and Disorders of the Ministry of Education, Chongqing, People’s Republic of China *These authors contributed equally to this work Background: Amphotericin B (AMB is a polyene antibiotic with broad spectrum antifungal activity, but its clinical toxicities and poor solubility limit the wide application of AMB in clinical practice. Recently, new drug-loaded nanoparticles (NPs – diblock copolymer D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide (PLGA-TPGS – have received special attention for their reduced toxicity, and increased effectiveness of drug has also been reported. This study aimed to develop AMB-loaded PLGA-TPGS nanoparticles (AMB-NPs and evaluate their antifungal effects in vitro and in vivo.Methods: AMB-NPs were prepared with a modified nanoprecipitation method and then characterized in terms of physical characteristics, in vitro drug release, stability, drug-encapsulation efficiency, and toxicity. Finally, the antifungal activity of AMB-NPs was investigated in vitro and in vivo.Results: AMB-NPs were stable and spherical, with an average size of around 110 nm; the entrapment efficacy was closed to 85%, and their release exhibited a typically biphasic pattern. The actual

Preparation and characterization of amorphous amphotericin B nanoparticles for oral administration through liquid antisolvent precipitation.

Science.gov (United States)

Zu, Yuangang; Sun, Wei; Zhao, Xiuhua; Wang, Weiguo; Li, Yong; Ge, Yunlong; Liu, Ying; Wang, Kunlun

2014-03-12

We prepared amphotericin B (AmB) nanoparticles through liquid antisolvent precipitation (LAP) and by freeze-drying to improve the solubility of AmB for oral administration. The LAP was optimized through a single-factor experiment. We determined the effects of surfactants and their concentration, the stirring time, the precipitation temperature, the stirring intensity, the drug concentration and the volume ratio of antisolvent to solvent on the mean particle size (MPS) of the AmB nanoparticles. Increased stirring intensity and precipitation time favored AmB nanoparticles with smaller MPS, but precipitation times exceeding 30 min did not further reduce the MPS. Increased Tween-80 concentration and the drug concentration decreased the MPS of the AmB nanoparticles. Increased precipitation temperature and antisolvent to solvent volume ratio initially decreased the MPS of the AmB nanoparticles, which increased thereafter. Optimum conditions produced AmB nanoparticles with an MPS of 135.1 nm. The AmB nanoparticles were characterized through scanning electron microscopy (SEM), mass spectrometry (MS), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermal gravimetric analysis (TG), solvent residue, drug purity test, and dissolution testing. The analyses indicated that the chemical structure of AmB remained unchanged in the nanoparticles, but the structure was changed from crystalline to amorphous. The residual DMSO in the nanoparticles was 0.24% less than the standard set by the International Conference on Harmonization limit for class III solvents. The AmB nanoparticles exhibited 2.1 times faster dissolution rates and 13 times equilibrium solubility compared with the raw drug. The detection results indicate that the AmB nanoparticles potentially improved the oral absorption of AmB. Copyright © 2013 Elsevier B.V. All rights reserved.

Comparació de l’activitat muscular de determinats músculs del tronc i de les extremitats inferiors en la marxa de dones joves amb peus en supinació, pronació i neutre

OpenAIRE

Khodaveisi, Hamideh; Sadeghi, Haydar; Memar, Raghad; Anbarian, Mehrdad

2016-01-01

  Els canvis de l’estructura anatómica del peu en redueixen la capacitat de funcionament normal. Aquest estudi tingué l’objectiu de comparar determinats músculs del tronc i les extremitats inferiors durant la marxa de persones amb diferents tipus de peu. Es classificaren 45 estudiants dones en 3 grups, segons l’estructura del peu, és a dir, en pronació, en supinació i neutre. Un metge especialista definí els tipus de peu mitjançant l’índex postural i raigs X. Es registraren les activitats ele...

Investigation of the response characteristics of OSL albedo neutron dosimeters in a 241AmBe reference neutron field

Science.gov (United States)

Liamsuwan, T.; Wonglee, S.; Channuie, J.; Esoa, J.; Monthonwattana, S.

2017-06-01

The objective of this work was to systematically investigate the response characteristics of optically stimulated luminescence Albedo neutron (OSLN) dosimeters to ensure reliable personal dosimetry service provided by Thailand Institute of Nuclear Technology (TINT). Several batches of InLight® OSLN dosimeters were irradiated in a reference neutron field generated by the in-house 241AmBe neutron irradiator. The OSL signals were typically measured 24 hours after irradiation using the InLight® Auto 200 Reader. Based on known values of delivered neutron dose equivalent, the reading correction factor to be used by the reader was evaluated. Subsequently, batch homogeneity, dose linearity, lower limit of detection and fading of the OSLN dosimeters were examined. Batch homogeneity was evaluated to be 0.12 ± 0.05. The neutron dose response exhibited a linear relationship (R2=0.9974) within the detectable neutron dose equivalent range under test (0.4-3 mSv). For this neutron field, the lower limit of detection was between 0.2 and 0.4 mSv. Over different post-irradiation storage times of up to 180 days, the readings fluctuated within ±5%. Personal dosimetry based on the investigated OSLN dosimeter is considered to be reliable under similar neutron exposure conditions, i.e. similar neutron energy spectra and dose equivalent values.

Highly Efficient Method for the Synthesis of Activated Mesoporous Biocarbons with Extremely High Surface Area for High-Pressure CO2 Adsorption.

Science.gov (United States)

Singh, Gurwinder; Lakhi, Kripal S; Kim, In Young; Kim, Sungho; Srivastava, Prashant; Naidu, Ravi; Vinu, Ajayan

2017-09-06

A simple and efficient way to synthesize activated mesoporous biocarbons (AMBs) with extremely high BET surface area and large pore volume has been achieved for the first time through a simple solid state activation of freely available biomass, Arundo donax, with zinc chloride. The textural parameters of the AMB can easily be controlled by varying the activation temperature. It is demonstrated that the mesoporosity of AMB can be finely tuned with a simple adjustment of the amount of activating agent. AMB with almost 100% mesoporosity can be achieved using the activating agent and the biomass ratio of 5 and carbonization at 500 °C. Under the optimized conditions, AMB with a BET surface area of 3298 m 2 g -1 and a pore volume of 1.9 cm 3 g -1 can be prepared. While being used as an adsorbent for CO 2 capture, AMB registers an impressively high pressure CO 2 adsorption capacity of 30.2 mmol g -1 at 30 bar which is much higher than that of activated carbon (AC), multiwalled carbon nanotubes (MWCNTs), highly ordered mesoporous carbons, and mesoporous carbon nitrides. AMB also shows high stability with excellent regeneration properties under vacuum and temperatures of up to 250 °C. These impressive textural parameters and high CO 2 adsorption capacity of AMB clearly reveal its potential as a promising adsorbent for high-pressure CO 2 capture and storage application. Also, the simple one-step synthesis strategy outlined in this work would provide a pathway to generate a series of novel mesoporous activated biocarbons from different biomasses.

Oral administration of amphotericin B nanoparticles: antifungal activity, bioavailability and toxicity in rats.

Science.gov (United States)

Radwan, Mahasen A; AlQuadeib, Bushra T; Šiller, Lidija; Wright, Matthew C; Horrocks, Benjamin

2017-11-01

Amphotericin B (AMB) is used most commonly in severe systemic life-threatening fungal infections. There is currently an unmet need for an efficacious (AMB) formulation amenable to oral administration with better bioavailability and lower nephrotoxicity. Novel PEGylated polylactic-polyglycolic acid copolymer (PLGA-PEG) nanoparticles (NPs) formulations of AMB were therefore studied for their ability to kill Candida albicans (C. albicans). The antifungal activity of AMB formulations was assessed in C. albicans. Its bioavalability was investigated in nine groups of rats (n = 6). Toxicity was examined by an in vitro blood hemolysis assay, and in vivo nephrotoxicity after single and multiple dosing for a week by blood urea nitrogen (BUN) and plasma creatinine (PCr) measurements. The MIC of AMB loaded to PLGA-PEG NPs against C. albicans was reduced two to threefold compared with free AMB. Novel oral AMB delivery loaded to PLGA-PEG NPs was markedly systemically available compared to Fungizone® in rats. The addition of 2% of GA to the AMB formulation significantly (p bioavailability from 1.5 to 10.5% and the relative bioavailability was > 790% that of Fungizone®. The novel AMB formulations showed minimal toxicity and better efficacy compared to Fungizone®. No nephrotoxicity in rats was detected after a week of multiple dosing of AMB NPs based on BUN and PCr, which remained at normal levels. An oral delivery system of AMB-loaded to PLGA-PEG NPs with better efficacy and minimal toxicity was formulated. The addition of glycyrrhizic acid (GA) to AMB NPs formulation resulted in a significant oral absorption and improved bioavailability in rats.

Das amarras do poder às entrelinhas do discurso: a pedagogia ambígua da favela em Capão Pecado, de Ferréz

Directory of Open Access Journals (Sweden)

Juan Filipe Stacul

2016-12-01

Full Text Available Pretende-se, no presente trabalho, investigar como o narrador de Capão Pecado propõe um contraponto ao código de moral da marginalidade, assumindo um tom pedagógico ambíguo que, ao mesmo tempo, critica o “sistema” e valoriza as regras de moralidade por este pregoadas. Para tal análise, pretende-se relacionar a instância narrativa da obra em questão com os pressupostos teóricos de Michel Foucault sobre a dissolução das relações de poder, representada pela figura do panóptico. Verifica-se, com isso, que os valores morais da sociedade tradicional burguesa dissolvem-se nas mais diversas estruturas, diluindo, nesse processo, algumas fronteiras entre centro e margem para se estabelecer como norma até mesmo onde são questionados e subvertidos.

Post-exposure treatment with nasal atropine methyl bromide protects against microinstillation inhalation exposure to sarin in guinea pigs

International Nuclear Information System (INIS)

Che, Magnus M.; Conti, Michele; Chanda, Soma; Boylan, Megan; Sabnekar, Praveena; Rezk, Peter; Amari, Ethery; Sciuto, Alfred M.; Gordon, Richard K.; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.

2009-01-01

We evaluated the protective efficacy of nasal atropine methyl bromide (AMB) which does not cross the blood-brain barrier against sarin inhalation exposure. Age and weight matched male guinea pigs were exposed to 846.5 mg/m 3 sarin using a microinstillation inhalation exposure technique for 4 min. The survival rate at this dose was 20%. Post-exposure treatment with nasal AMB (2.5 mg/kg, 1 min) completely protected against sarin induced toxicity (100% survival). Development of muscular tremors was decreased in animals treated with nasal AMB. Post-exposure treatment with nasal AMB also normalized acute decrease in blood oxygen saturation and heart rate following sarin exposure. Inhibition of blood AChE and BChE activities following sarin exposure was reduced in animals treated with nasal AMB, indicating that survival increases the metabolism of sarin or expression of AChE. The body weight loss of animals exposed to sarin and treated with nasal AMB was similar to saline controls. No differences were observed in lung accessory lobe or tracheal edema following exposure to sarin and subsequent treatment with nasal AMB. Total bronchoalveolar lavage fluid (BALF) protein, a biomarker of lung injury, showed trends similar to saline controls. Surfactant levels post-exposure treatment with nasal AMB returned to normal, similar to saline controls. Alkaline phosphatase levels post-exposure treatment with nasal AMB were decreased. Taken together, these data suggest that nasal AMB blocks the copious airway secretion and peripheral cholinergic effects and protects against lethal inhalation exposure to sarin thus increasing survival.

Properties of An Oral Nanoformulation of A Molecularly Dispersed Amphotericin B Comprising A Composite Matrix of Theobroma Oil and Bee’S Wax

Directory of Open Access Journals (Sweden)

Chloe See Wei Tan

2014-12-01

Full Text Available An amphotericin B-containing (AmB solid lipid nanoparticulate drug delivery system intended for oral administration, comprised of bee’s wax and theobroma oil as lipid components was formulated with the aim to ascertain the location of AmB within the lipid matrix: (a a homogenous matrix; (b a drug-enriched shell; or (c a drug enriched core. Both the drug-loaded and drug-free nanoparticles were spherical with AmB contributing to an increase in both the z-average diameter (169 ± 1 to 222 ± 2 nm and zeta potential (40.8 ± 0.9 to 50.3 ± 1.0 mV of the nanoparticles. A maximum encapsulation efficiency of 21.4% ± 3.0%, corresponding to 10.7 ± 0.4 mg encapsulated AmB within the lipid matrix was observed. Surface analysis and electron microscopic imaging indicated that AmB was dispersed uniformly within the lipid matrix (option (a above and, therefore, this is the most suitable of the three models with regard to modeling the propensity for uptake by epithelia and release of AmB in lymph.

Outcomes associated with conventional versus lipid-based formulations of amphotericin B in propensity-matched groups

Directory of Open Access Journals (Sweden)

Campbell RS

2013-10-01

Full Text Available Rebecca S Campbell,1 Paresh Chaudhari,2 Harlen D Hays,1 Robert J Taylor,1 Brian H Nathanson,3 Samuel A Bozzette,1 David Horn4 1Cerner Research, Culver City, CA, USA; 2Astellas Scientific and Medical Affairs, Inc., Northbrook, IL, USA; 3OptiStatim, LLC, Longmeadow, MA, USA; 4David Horn LLC, Doylestown, PA, USA Background: Lipid-based formulations of amphotericin B (LF-AMB are indicated for treatment of invasive fungal infections in patients intolerant to conventional amphotericin B (CAB or with refractory infections. Physicians still may choose to administer CAB to such patients. We described the use of CAB and LF-AMB in this population and quantified differences in post-amphotericin B length of stay (LOS among survivors and hospital mortality in matched patients. Methods: Data were extracted from Health Facts (Cerner Corporation, Kansas City, MO, USA for a retrospective cohort analysis. Inpatients aged ≥18 years with evidence of fungal infection and with orders for LF-AMB or CAB on  ≥2 days from January 2001 to June 2010 were identified. Patients were required to have renal insufficiency or other relative contraindications to use of CAB, exposure to nephrotoxic agents, or evidence of a CAB-refractory infection. Multilevel (hierarchical mixed-effects logistic regression was used to determine factors associated with initial exposure to LF-AMB versus CAB. Multivariate adjustment of outcomes was done using propensity score matching. Results: 655 patients were identified: 322 patients initiated therapy with CAB and 333 initiated treatment with LF-AMB. Compared to those initiating CAB, patients initiating LF-AMB had greater acuity and underlying disease severity. In unadjusted analyses, hospital mortality was significantly higher in the LF-AMB group (32.2% versus 23.7%; P = 0.02. After propensity score matching and covariate adjustment, mortality equalized and observed differences in LOS after amphotericin B initiation decreased. Conclusion

Efficacy of a poly-aggregated formulation of amphotericin B in treating systemic sporotrichosis caused by Sporothrix brasiliensis.

Science.gov (United States)

Ishida, Kelly; Castro, Rafaela Alves; Torrado, Juan J; Serrano, Dolores Remedios; Borba-Santos, Luana Pereira; Quintella, Leonardo Pereira; de Souza, Wanderley; Rozental, Sonia; Lopes-Bezerra, Leila M

2018-04-01

In severe cases of sporotrichosis, it is recommended to use amphotericin B deoxycholate (D-AMB) or its lipid formulations and/or in association with itraconazole (ITC). Our aim was to evaluate the antifungal efficacy of a poly-aggregated amphotericin B (P-AMB), a nonlipid formulation, compared with D-AMB on systemic sporotrichosis caused by Sporothrix brasiliensis. In vitro assays showed that Sporothrix schenckii sensu stricto and S. brasiliensis yeast clinical isolates were susceptible to low concentrations of P-AMB and D-AMB. Although P-AMB presented a higher minimal inhibitory concentration (MIC) compared to D-AMB, its cytotoxic effect on renal cells and erythrocytes was lower. For the in vivo assays, male BALB/c mice were intravenously infected with S. brasiliensis yeasts, and P-AMB or D-AMB was administered 3 days post-infection. The efficacy of five therapeutic regimens was tested: intravenous monotherapy with P-AMB or D-AMB, intravenous pulsed-therapy with P-AMB or D-AMB, and intravenous therapy with P-AMB, followed by oral ITC. These treatments increased murine survival and controlled the fungal burden in the liver, spleen, lungs, and kidneys. However, only D-AMB monotherapy or the pulsed-therapies with D-AMB or P-AMB led to 100% survival of the mice 45 days post-infection; only pulsed administration of D-AMB was able to control the fungal load in all organs 45 days post-infection. Accordingly, the histopathological findings showed reductions in the fungal burden and inflammatory reactions in these treatment regimens. Together, our results suggest that the P-AMB formulation could be considered as an alternative drug to D-AMB for treating disseminated sporotrichosis.

[Activity of amphotericin B and anidulafungin, alone and combined, against Candida tropicalis biofilms developed on Teflon® and titanium].

Science.gov (United States)

Fernández-Rivero, Marcelo Ernesto; Del Pozo, José L; Valentín, Amparo; Fornes, Victoria; Molina de Diego, Araceli; Pemán, Javier; Cantón, Emilia

Current therapeutic strategies have a limited efficacy against Candida biofilms that form on the surfaces of biomedical devices. Few studies have evaluated the activity of antifungal agents against Candida tropicalis biofilms. To evaluate the activity of amphotericin B (AMB) and anidulafungin (AND), alone and in combination, against C. tropicalis biofilms developed on polytetrafluoroethylene (teflon -PTFE) and titanium surfaces using time-kill assays. Assays were performed using the CDC Biofilm Reactor equipped with PTFE and titanium disks with C. tropicalis biofilms after 24h of maturation. The concentrations assayed were 40mg/l for AMB and 8mg/l for AND, both alone and combined. After 24, 48 and 72h of exposure to the antifungals, the cfu/cm 2 was determined by a vortexing-sonication procedure. AMB reduced biofilm viable cells attached to PTFE and titanium by ≥99% and AND by 89.3% on PTFE and 96.8% on titanium. The AMB+AND combination was less active than AMB alone, both on PTFE (decrease of cfu/cm 2 3.09 Log 10 vs. 1.08 when combined) and titanium (4.51 vs. 1.53 when combined), being the interaction irrelevant on both surfaces. AMB is more active than AND against C. tropicalis biofilms. Yeast killing rates are higher on titanium than on PTFE surfaces. The combination of AMB plus AND is less effective than AMB alone on both surfaces. Copyright © 2017 Asociación Española de Micología. Publicado por Elsevier España, S.L.U. All rights reserved.

Considerações sobre eficiência administrativa relacionado aos exames de ultra-sonografia, tomografia computadorizada e ressonância magnética nas afecções orbitárias Reasons for the administrative efficiency related to ultrassonography, computed tomography and magnetic resonance imaging tests in orbital diseases

Directory of Open Access Journals (Sweden)

Magno Watanabe

2007-12-01

Full Text Available OBJETIVOS: Enfocar os exames de ultra-sonografia (US, tomografia computadorizada (TC e ressonância magnética (RM, levantando, revisando e discutindo as seguintes medidas na melhoria da eficiência destes procedimentos na órbita: 1- Defasagem dos honorários médicos; 2- Vantagens e desvantagens dos exames; 3- Diretrizes clínicas. MÉTODOS: No período de julho de 2002 a março de 2003, realizou-se um levantamento dos valores dos exames orbitários de US, TC e RM pagos pelo Sistema Único de Saúde - SUS, operadoras de planos e seguros de saúde e particulares cobrados em três clínicas oftalmológicas e três clínicas radiológicas referenciadas. Pesquisa bibliográfica e revisão na literatura dos referidos exames e suas diretrizes clínicas nas afecções orbitárias. RESULTADOS: 1- Valores dos exames em reais (R$: US: 9,05 - SUS / 81,77 - AMB 90 / 57,01 - AMB/CIEFAS 93 / 102,00 - AMB/LPM 99 / 158,33 - particular. TC: 86,76 - SUS / 193,70 - AMB 90 / 196,30 - AMB/CIEFAS 93 / 204,12 - AMB/LPM 99 / 255,33 - particular. RM: 268,75 - SUS / 475,80 - AMB 90 e AMB/CIEFAS 93 / 472,50 - AMB/LPM 99 / 563,33 - particular; 2- Vantagens e desvantagens dos exames descritos de acordo com a revisão da literatura; 3- As doenças da órbita não têm ainda listadas suas diretrizes. CONCLUSÃO: Estes exames são os mais utilizados e consagrados pela sua eficácia no estudo da órbita. Para uma maior eficiência, devemos considerar as seguintes recomendações administrativas: 1- Modernização e atualização das tabelas de honorários com índices mínimos e mais justos na remuneração dos exames com reembolso dos insumos utilizados como filmes radiológicos e contrastes: 2- Promover e estimular a educação médica continuada, evitando o excesso de exames desnecessários ou inapropriados: 3- Elaboração e implementação de diretrizes e protocolos clínicos baseados em evidências nas principais doenças orbitárias que possam ser utilizados como refer

Contribution of thin slice (1 mm) oblique coronal proton density-weighted MR images for assessment of anteromedial and posterolateral bundle damage in anterior cruciate ligament injuries

Energy Technology Data Exchange (ETDEWEB)

Gokalp, Gokhan, E-mail: drgokhangokalp@yahoo.com [Department of Radiology, Uludag University Medical Faculty, Gorukle, Bursa (Turkey); Demirag, Burak, E-mail: bdemirag@uludag.edu.tr [Department of Orthopedy, Uludag University Medical Faculty, Gorukle, Bursa (Turkey); Nas, Omer Fatih, E-mail: omerfatihnas@gmail.com [Department of Radiology, Uludag University Medical Faculty, Gorukle, Bursa (Turkey); Aydemir, Mehmet Fatih, E-mail: fatiha@yahoo.com [Department of Orthopedy, Uludag University Medical Faculty, Gorukle, Bursa (Turkey); Yazici, Zeynep, E-mail: zyazici@uludag.edu.tr [Department of Radiology, Uludag University Medical Faculty, Gorukle, Bursa (Turkey)

2012-09-15

Purpose: To evaluate the diagnostic efficacy of using additional oblique coronal 1 mm proton density-weighted (PDW) MR imaging of the knee for detection and grading anterior cruciate ligament (ACL), anteromedial bundle (AMB) and posterolateral bundle (PLB) injuries. Materials and methods: We prospectively assessed preoperative MR images of 50 patients (36 men, 14 women; age range, 18–62 years). First, we compared the diagnostic performance of routine sagittal (3 mm) and additional oblique coronal images (1 mm) for ACL tears. Then, we compared the tear types (AMB or PLB) and grade presumed from oblique coronal MR imaging with arthroscopy. Results: Arthroscopy revealed ACL tear in 24 (48%) patients. There was significant difference between sagittal images and arthroscopy results for ACL tear recognition (p < 0.001). No significant difference was detected for oblique coronal images when compared with arthroscopy results (p = 0.180). Sensitivity and specificity values for ACL tear diagnosis were 37.04% and 95.65% for sagittal images; 74.07% and 91.30% for oblique coronal images. There was no significant difference between arthroscopy and oblique coronal MR images in grading AMB and PLB injuries (p > 0.05). Conclusion: Addition of thin slice oblique coronal images to conventional sequences could better contribute to better verifying the presence of ACL tear and in determining its grade.

Inhalation of amphotericin B formulations for prevention and treatment of invasive pulmonary aspergillosis : an experimental study in rats

NARCIS (Netherlands)

E.J. Ruijgrok (Elisabeth)

2002-01-01

textabstractBecause current knowledge of inhalational AMB is limited, a rigorous scientific approach is warranted to establish opt"1mal dose, frequency and durat"1on of administration. We therefore decided to study in detail the fu II potential of nebulised AMB in different formulations, with the

Nonlinear dynamics near resonances of a rotor-active magnetic bearings system with 16-pole legs and time varying stiffness

Science.gov (United States)

Wu, R. Q.; Zhang, W.; Yao, M. H.

2018-02-01

In this paper, we analyze the complicated nonlinear dynamics of rotor-active magnetic bearings (rotor-AMB) with 16-pole legs and the time varying stiffness. The magnetic force with 16-pole legs is obtained by applying the electromagnetic theory. The governing equation of motion for rotor-active magnetic bearings is derived by using the Newton's second law. The resulting dimensionless equation of motion for the rotor-AMB system is expressed as a two-degree-of-freedom nonlinear system including the parametric excitation, quadratic and cubic nonlinearities. The averaged equation of the rotor-AMB system is obtained by using the method of multiple scales when the primary parametric resonance and 1/2 subharmonic resonance are taken into account. From the frequency-response curves, it is found that there exist the phenomena of the soft-spring type nonlinearity and the hardening-spring type nonlinearity in the rotor-AMB system. The effects of different parameters on the nonlinear dynamic behaviors of the rotor-AMB system are investigated. The numerical results indicate that the periodic, quasi-periodic and chaotic motions occur alternately in the rotor-AMB system.

Multi-pulse chaotic motions of a rotor-active magnetic bearing system with time-varying stiffness

International Nuclear Information System (INIS)

Zhang, W.; Yao, M.H.; Zhan, X.P.

2006-01-01

In this paper, we investigate the Shilnikov type multi-pulse chaotic dynamics for a rotor-active magnetic bearings (AMB) system with 8-pole legs and the time-varying stiffness. The stiffness in the AMB is considered as the time-varying in a periodic form. The dimensionless equation of motion for the rotor-AMB system with the time-varying stiffness in the horizontal and vertical directions is a two-degree-of-freedom nonlinear system with quadratic and cubic nonlinearities and parametric excitation. The asymptotic perturbation method is used to obtain the averaged equations in the case of primary parametric resonance and 1/2 subharmonic resonance. It is found from the numerical results that there are the phenomena of the Shilnikov type multi-pulse chaotic motions for the rotor-AMB system. A new jumping phenomenon is discovered in the rotor-AMB system with the time-varying stiffness

Africa Development - Vol 38, No 1&2 (2013)

African Journals Online (AJOL)

US Foreign Policy under President Barack Obama and the Promotion of Multilateralism and the Rule of Law · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. AMB Mangu, 171-190 ...

Antifungal prophylaxis in chemotherapy-associated neutropenia: a retrospective, observational study

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Martin Thomas

2007-07-01

Full Text Available Abstract Background In August 2002, the antifungal prophylaxis algorithm for neutropenic hematology/oncology (NHO patients at the Medical Center was changed from conventional amphotericin (AMB to an azole (AZ based regimen (fluconazole [FLU] in low-risk and voriconazole [VOR] in high-risk patients. The aim of our study was to compare outcomes associated with the two regimens, including breakthrough fungal infection, adverse drug events, and costs. Methods Adult, non-febrile, NHO patients who received prophylactic AMB from 8/01/01-7/30/02 or AZ from 8/01/02-7/30/03 were retrospectively evaluated. Results A total of 370 patients (AMB: n = 181; AZ: n = 216 associated with 580 hospitalizations (AMB: n = 259; AZ: n = 321 were included. The incidence of probable/definite breakthrough Aspergillus infections was similar among regimens (AMB: 1.9% vs AZ: 0.6%; p=0.19. A greater incidence of mild/moderate (24.7% vs. 5.3%; p $9,000 increase in mean total costs/hospitalization, the mean acquisition cost associated with AZ was only $947/hospitalization more than AMB. Conclusion While an AZ-based regimen is associated with increased cost, the reduced rate of nephrotoxicity and availability of oral dosage forms, suggests that azoles be used preferentially over AMB. However, an increased rate of severe hepatic toxicity may be associated with VOR.

Protective and antifungal properties of Nanodisk-Amphotericin B over commercially available Amphotericin B

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Do-Yeon Cho

2017-03-01

Full Text Available Objective: Amphotericin B (AMB, a potent antifungal agent, has been employed as topical and systemic therapy for sinonasal fungal infections. A novel formulation of nanodisc (ND containing super aggregated AMB (ND-AMB for the treatment of fungal infections has been recently developed to provide greater protection from AMB toxicity than current, clinically approved lipid-based formulations. The objective of the current study was to evaluate the safety and potency of ND-AMB for sinonasal delivery using an in vitro model. Methods: Human sinonasal tissue was harvested during endoscopic sinus surgery and grown at air–liquid interface until well-differentiated. Cultures were exposed to ND-AMB vs AMB and changes in K+ permeability and resistance were measured and recorded via Ussing chamber assay. Ciliary beat frequency (CBF was analyzed in parallel as well as cytotoxic assay. Potency was assessed using real-time PCR measurement of the Aspergillus fumigatus 18S rRNA. Results: Ussing chamber studies revealed K+ currents that increased rapidly within 30 s of adding AMB (10 μg/mL to the apical side, indicating apical membranes had become permeable to K+ ions. In contrast, negligible induction of K+ current was obtained following addition of ND-AMB [AMB = (107.7 ± 15.9 μA/cm2 AMB vs ND-AMB = (2.3 ± 0.7 μA/cm2 ND-AMB; P = 0.005]. ND-AMB also protected nasal epithelial cells from cytotoxicity of AMB (P < 0.05. There was no difference in ciliary beat frequency between the two groups (P = 0.96. The expression of A. fumigatus 18S rRNA with exposure of lower dose of ND-AMB was significantly lower compared to that with AMB (P < 0.05. Conclusions: Data from the present study suggests ND-AMB protects human nasal epithelia membranes from AMB toxicity by protecting against apical cell K+ permeability while maintaining uncompromised antifungal property compared to AMB. ND-AMB could provide

Contribution of thin slice (1 mm) oblique coronal proton density-weighted MR images for assessment of anteromedial and posterolateral bundle damage in anterior cruciate ligament injuries

International Nuclear Information System (INIS)

Gokalp, Gokhan; Demirag, Burak; Nas, Omer Fatih; Aydemir, Mehmet Fatih; Yazici, Zeynep

2012-01-01

Purpose: To evaluate the diagnostic efficacy of using additional oblique coronal 1 mm proton density-weighted (PDW) MR imaging of the knee for detection and grading anterior cruciate ligament (ACL), anteromedial bundle (AMB) and posterolateral bundle (PLB) injuries. Materials and methods: We prospectively assessed preoperative MR images of 50 patients (36 men, 14 women; age range, 18–62 years). First, we compared the diagnostic performance of routine sagittal (3 mm) and additional oblique coronal images (1 mm) for ACL tears. Then, we compared the tear types (AMB or PLB) and grade presumed from oblique coronal MR imaging with arthroscopy. Results: Arthroscopy revealed ACL tear in 24 (48%) patients. There was significant difference between sagittal images and arthroscopy results for ACL tear recognition (p 0.05). Conclusion: Addition of thin slice oblique coronal images to conventional sequences could better contribute to better verifying the presence of ACL tear and in determining its grade

Effects of regular physical activity on anthropometric and functional parameters in young and old women

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Sebastião Gobbi

2001-12-01

Full Text Available The aim of the present study was to verify the strength levels and the arm cross-sectional-area (AMB of young and old women who practice physical activity regularly. Thirty female subjects were selected and distributed into two groups: young (G1 and old (G2. They were evaluated on maximal voluntary strength of elbow flexor muscle by 1RM (one-maximal repetition test (“biceps curl”, and the AMB, through the measures of arm circumference (CB and triceps skinfold (DCTr, which were then used with the equation proposed by Frisancho (1984: AMB (cm2 = [(CB - pDCTr2 / 4p] - 6.5, in both dominant (MD and non dominant (MND arms. Strength (kg and AMB (cm2 were analyzed by ANOVA to a significance level of 5%. The G2 strength level was significantly (p RESUMO O presente estudo teve como objetivo verificar os níveis de força e a área muscular do braço (AMB de mulheres jovens e idosas praticantes de atividade física regular. Para isso foram selecionados 30 sujeitos do sexo feminino, distribuídos em dois grupos: jovem (G1 e idoso (G2. Avaliou-se a força voluntária máxima dos músculos flexores do cotovelo pelo teste de 1RM (repetição máxima exercício “rosca unilateral” , e a AMB, através das medidas de circunferência de braço (CB e dobra cutânea tricipital (DCTr, que posteriormente foram incluídas na equação proposta por Frisancho (1984: AMB (cm = [(CB - pDCTr2 / 4p] - 6.5, em ambos os membros dominante (MD e não dominante (MND. Os valores de força (em kg e AMB (em cm2 foram analisados por ANOVA com nível de significância pré-estabelecido em 5%. O nível de força do G2 foi significativamente (p<0,01 menor que G1, tanto no MD quanto no MND. Em relação à AMB, o MND de G2 mostrou-se maior que G1, o que não ocorreu com o MD. A partir da análise dos resultados, concluiu-se que apesar do envelhecimento, a prática regular de atividade física pode prevenir a perda de massa muscular (MM. Contudo, a capacidade para gerar for

Effect of endothelin antagonism on apnea frequency following chronic intermittent hypoxia.

Science.gov (United States)

Donovan, Lucas M; Liu, Yuzhen; Weiss, J Woodrow

2014-04-01

Chronic hypoxia increases the hypoxic ventilatory response (HVR). Augmented HVR contributes to central apneas seen in heart failure and complex sleep apnea. Endothelin receptor (ETR) antagonism decreases carotid body afferent activity following chronic intermittent hypoxia (CIH). We speculated ETR antagonism would reduce HVR and apneas following CIH. HVR and apneas were measured after exposure to CIH and room air sham (SHAM). ETR blocker Ambrisentan was administered via the chow of CIH-exposed animals from days 1 to 12 of CIH (CIH/AMB). A separate crossover group was exposed to CIH and fed normal chow (placebo) days 1-6, and Ambrisentan days 7-12 (CIH/PLA-AMB). SHAM and CIH/PLA animals were fed placebo days 1-12. The CIH/AMB and CIH/PLA-AMB rats had reduced HVR compared to CIH/PLA, similar HVR compared to sham exposed animals, and reduced apnea frequency compared to CIH/PLA animals. The reduced HVR and post-hypoxic apneas resulting from Ambrisentan administration suggests ETR antagonists may have utility in reducing central apneas following CIH. Copyright © 2014 Elsevier B.V. All rights reserved.

Experimental Evaluation of Superconductor Flywheel Energy Storage System with Hybrid Type Active Magnetic Bearing

International Nuclear Information System (INIS)

Lee, J. P.; Kim, H. G.; Han, S. C.

2012-01-01

In this paper, we designed Active Magnetic Bearing (AMB) for large scale Superconductor Flywheel Energy Storage System (SFESS) and PD controller for AMB. And we experimentally evaluated SFESS including hybrid type AMB. The radial AMB was designed to provide force slew rate that was sufficient for the unbalance disturbances at the maximum operating speed. The thrust AMB is a hybrid type where a permanent magnet carries the weight of the flywheel and an electromagnetic actuator generates the dynamic control force. We evaluated the design performance of the manufactured AMB through comparison of FEM analysis and the results of experimental force measurement. In order to obtain gains of PD controller and design a notch filter, the system identification was performed through measuring frequency response including dynamics for the AMBs, a power amp and a sensor using a sine swept test method after levitating the flywheel. Through measuring the current input of the AMBs and the orbit of a flywheel according to rotational speed, we verified excellent control performance of the AMBs with small amount current for the large scale SFESS.

The Arabidopsis mitogen-activated protein kinase 6 is associated with γ-tubulin on microtubules, phosphorylates EB1c and maintains spindle orientation under nitrosative stress

Czech Academy of Sciences Publication Activity Database

Kohoutová, Lucie; Kourová, Hana; Nagy, S. K.; Volc, Jindřich; Halada, Petr; Mészáros, T.; Meskiene, I.; Bögre, L.; Binarová, Pavla

2015-01-01

Roč. 207, č. 4 (2015), s. 1061-1074 ISSN 0028-646X R&D Projects: GA MŠk 7AMB13AT013; GA ČR GAP501/12/2333 Institutional support: RVO:61388971 Keywords : Arabidopsis * cell division * EB1c Subject RIV: EE - Microbiology, Virology Impact factor: 7.210, year: 2015

Transcriptional Profiles of the Response to Ketoconazole and Amphotericin B in Trichophyton rubrum▿ †

Science.gov (United States)

Yu, Lu; Zhang, Wenliang; Wang, Lingling; Yang, Jian; Liu, Tao; Peng, Junping; Leng, Wenchuan; Chen, Lihong; Li, Ruoyu; Jin, Qi

2007-01-01

Trichophyton rubrum is a pathogenic filamentous fungus of increasing medical concern. Two antifungal agents, ketoconazole (KTC) and amphotericin B (AMB), have specific activity against dermatophytes. To identify the mechanisms of action of KTC and AMB against T. rubrum, a cDNA microarray was constructed from the expressed sequence tags of the cDNA library from different developmental stages, and transcriptional profiles of the responses to KTC and AMB were determined. T. rubrum was exposed to subinhibitory concentrations of KTC and AMB for 12 h, and microarray analysis was used to examine gene transcription. KTC exposure induced transcription of genes involved in lipid, fatty acid, and sterol metabolism, including ERG11, ERG3, ERG25, ERG6, ERG26, ERG24, ERG4, CPO, INO1, DW700960, CPR, DW696584, DW406350, and ATG15. KTC also increased transcription of the multidrug resistance gene ABC1. AMB exposure increased transcription of genes involved in lipid, fatty acid, and sterol metabolism (DW696584, EB801458, IVD, DW694010, DW688343, DW684992), membrane transport (Git1, DW706156, DW684040, DMT, DW406136, CCH1, DW710650), and stress-related responses (HSP70, HSP104, GSS, AOX, EB801455, EB801702, TDH1, UBI4) but reduced transcription of genes involved in maintenance of cell wall integrity and signal transduction pathways (FKS1, SUN4, DW699324, GAS1, DW681613, SPS1, DW703091, STE7, DW703091, DW695308) and some ribosomal proteins. This is the first report of the use of microarray analysis to determine the effects of drug action in T. rubrum. PMID:17060531

Seasonal variability in nitrate and phosphate uptake kinetics in a forested headwater stream using pulse nutrient additions

Science.gov (United States)

Griffiths, N. A.; Mulholland, P. J.

2011-12-01

We used the Tracer Additions for Spiraling Curve Characterization (TASCC) approach to quantify seasonal variability in ambient nutrient spiraling metrics and nutrient uptake kinetics in the West Fork of Walker Branch, a forested headwater stream in eastern Tennessee, USA. We performed instantaneous additions of nitrate (NO3-) and phosphate (PO4-3) separately with a conservative tracer (chloride, Cl-) during the following biologically-important time periods: autumn (during leaf fall, high organic matter [OM] standing stocks), winter (low OM standing stocks), spring (prior to canopy closure), and summer (closed canopy). We predicted that nutrient demand would be highest during autumn and spring, as OM inputs fuel heterotrophic respiration and high light availability stimulates autotrophic production, respectively. The measured ambient PO4-3 uptake rates (Vf-amb) followed our predictions, with the highest Vf-amb rates in autumn (Vf-amb = 2.8 mm/min) and spring (Vf-amb = 2.9 mm/min), and undetectable uptake in winter. Further, maximum areal PO4-3 uptake rates (Umax) were higher in autumn (Umax = 297 μg/m2/min) than spring (Umax = 106 μg/m2/min), possibly due to greater nutrient demand of heterotrophs on leaf litter accumulations. Contrary to our predictions, ambient NO3- uptake rates were highest in autumn and winter (autumn: Vf-amb = 2.8 mm/min, winter: Vf-amb = 2.4 mm/min), and lowest in spring (Vf-amb = 1.0 mm/min). The higher than expected Vf-amb rate in winter may be due to higher stream metabolism rates and thus greater nitrogen demand; the lower than expected Vf-amb rate in spring may reflect an alleviation of nitrogen demand due to high ammonium concentrations during this time. As the demand for both nitrogen and phosphorus in Walker Branch is greatest in autumn, future work will characterize how nutrient metrics change during this dynamic time period (i.e., before, during, and after leaf fall).

Costo-efficacia dell’amfotericina B liposomiale nella terapia dell’aspergillosi invasiva

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Mario Eandi

2004-03-01

Full Text Available Invasive aspergillosis (IA is a common and life-threatening infectious complication of immune system depression. Amphotericin B deoxycholate (AMB-d has been considered standard therapy for IA for over 40 years, despite the fact that success rates rarely exceed 40% and adverse effects are quite common. At present two more recent pharmacological agents are available for the treatment of IA: liposomal amphotericin B (L-AMB and voriconazole (VOR. In this article, we present a pharmaco-economical study comparing the relative costeffectiveness of 5 alternative strategies in the treatment of invasive aspergillosis, analysed from the point of view of the Italian hospital: administration of L-AMB as first line therapy, followed by no rescue treatment in case of failure (L-AMB I°; administration of L-AMB as first line therapy, followed by VOR in case of failure (LAMB I° + VOR rescue; AMB-d as first line, followed by L-AMB in case of failure (L-AMB rescue; AMB-d as first line, followed by other antifungals as needed (AMB-d I° and VOR as first line, followed by rescue treatments in case of failure (VOR I°. The cost-effectiveness analysis was conducted using decision tree modelling techniques: efficacy data were obtained from published clinical trials; costs parameters were fitted on the Italian setting. The results indicate that two strategies, L-AMB rescue and VOR I°, are dominated, i.e. induce higher costs and lower success rates than the alternatives. The three remaining strategies are neither dominated nor dominate the others, but are associated with different clinical and economical outcomes: AMB-d I° has the lowest total cost, but also the highest cost-effectiveness ratio and the lowest overall efficacy; L-AMB I° has the best cost-effectiveness, but requires the willingness to pay 2,100 euro for each additional success; L-AMB I° + VOR rescue is the most effective treatment, but this choice is associated with incremental costs of 17,200 euro

Nonlinear Control of an Active Magnetic Bearing System Achieved Using a Fuzzy Control with Radial Basis Function Neural Network

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Seng-Chi Chen

2014-01-01

Full Text Available Studies on active magnetic bearing (AMB systems are increasing in popularity and practical applications. Magnetic bearings cause less noise, friction, and vibration than the conventional mechanical bearings; however, the control of AMB systems requires further investigation. The magnetic force has a highly nonlinear relation to the control current and the air gap. This paper proposes an intelligent control method for positioning an AMB system that uses a neural fuzzy controller (NFC. The mathematical model of an AMB system comprises identification followed by collection of information from this system. A fuzzy logic controller (FLC, the parameters of which are adjusted using a radial basis function neural network (RBFNN, is applied to the unbalanced vibration in an AMB system. The AMB system exhibited a satisfactory control performance, with low overshoot, and produced improved transient and steady-state responses under various operating conditions. The NFC has been verified on a prototype AMB system. The proposed controller can be feasibly applied to AMB systems exposed to various external disturbances; demonstrating the effectiveness of the NFC with self-learning and self-improving capacities is proven.

CACNA1H missense mutations associated with amyotrophic lateral sclerosis alter Ca(v)3.2 T-type calcium channel activity and reticular thalamic neuron firing

Czech Academy of Sciences Publication Activity Database

Rzhepetskyy, Yuriy; Lazniewska, Joanna; Blesneac, I.; Pamphlett, R.; Weiss, Norbert

2016-01-01

Roč. 10, č. 6 (2016), s. 466-477 ISSN 1933-6950 R&D Projects: GA ČR GA15-13556S; GA MŠk 7AMB15FR015 Institutional support: RVO:61388963 Keywords : ALS * amyotrophic lateral sclerosis * biophysics * CACNA1H * Ca(v)3 * 2 channel Subject RIV: CE - Biochemistry Impact factor: 2.042, year: 2016

Application of active magnetic bearings in flexible rotordynamic systems - A state-of-the-art review

Science.gov (United States)

Siva Srinivas, R.; Tiwari, R.; Kannababu, Ch.

2018-06-01

In this paper a critical review of literature on applications of Active Magnetic Bearings (AMBs) systems in flexible rotordynamic systems have been presented. AMBs find various applications in rotating machinery; however, this paper mainly focuses on works in vibration suppression and associated with the condition monitoring using AMBs. It briefly introduces reader to the AMB working principle, provides details of various hardware components of a typical rotor-AMB test rig, and presents a background of traditional methods of vibration suppression in flexible rotors and the condition monitoring. It then moves on to summarize the basic features of AMB integrated flexible rotor test rigs available in literature with necessary instrumentation and its main objectives. A couple of lookup tables provide summary of important information of test rigs in papers within the scope of this article. Finally, future directions in AMB research within the paper's scope have been suggested.

Heme oxygenase-1 dependant pathway contributes to protection by tetramethylpyrazine against chronic hypoxic injury on medulla oblongata in rats.

Science.gov (United States)

Ding, Yan; Hou, Xuefei; Chen, Li; Zhou, Hua; Gong, Yanju; Dai, Liqun; Zheng, Yu

2016-02-15

Tetramethylpyrazine (TMP), one of the active ingredients of the Chinese herb Lingusticum Wallichii (Chuan Xiong) has been proved to protect the medulla oblongata from chronic hypoxia injury. However, the underlying mechanism remains unclear. The purpose of this study was to determine whether the protective effects of TMP are associated with the heme oxygenase-1 (HO-1) dependant pathway in adult rats. The morphological changes of neurons in the hypoglossal nucleus (12N), the nucleus ambiguus (Amb), the nucleus tractus solitarius (NTS), and the pre-Bötzinger complex (pre-BötC) were investigated by Nissl staining; the malondialdehyde (MDA) content and superoxide dismutase (SOD) activity were measured to evaluate the anti-oxidant effect; some apoptosis parameters, Bax mRNA and Bcl-2 mRNA, were tested; and the double immunochemistry staining of active caspase-3/NeuN was performed. Meanwhile, the HO-1 protein expression and heme oxygenase (HO) activity were examined. Tin-protoporphyrin (SnPP), a potent inhibitor of HO, was used to further confirm the effect of HO-1. We found that TMP ameliorated the neuron loss in 12N, Amb and NTS, the decrease in SOD activity and the increase in MDA content, the decrease in Bcl-2 mRNA of medulla oblongata (Pmedulla oblongata in the rats. Copyright © 2015 Elsevier B.V. All rights reserved.

La decisió artística i les seves condicions de producció: parlant amb un equip de rodatge Artistic Decision-making and its conditions for production: Talking to a TV crew La decisió artística i les seves condicions de producció: parlant amb un equip de rodatge

Directory of Open Access Journals (Sweden)

Dafne Muntanyola Saura

2012-07-01

Full Text Available

Em proposo destriar les condicions de producció de la mirada televisiva. La meva tasca sociològica en estudiar les pràctiques i decisions artístiques rau en fer explícits els contextos socials d’aquesta activitat professional. Expliquem aquesta pràctica tant discursiva com pragmática a partir d’una anàlisi de contingut temàtic de 20 entrevistes a participants d’un rodatge televisiu. Amb l’aplicació del programa ATLAS.ti, s’han definit les pràctiques socials que constitueixen el motor de reproducció de la distinció social. Aquesta anàlisi qualitiativa m’ha permès concretar operadors teòrics polivalents com són habitus i capital (Bourdieu, 1979; 1994; 1998, sovint massa ambigus per a ser emprats empíricament. La font de legitimitat de les decisions artístiques prové d’un tipus d’habitus artístic, que hem anomenat habitus televisiu. La dimensió relacional i instrumental del rodatge passa a un segon pla pels entrevistats. En definitiva, contractes de dependència que s’amaguen mitjançant l’exercici de la violència simbòlica quotidiana configuren les identitats professionals del món de la televisió.

My aim is to explain the production conditions of a TV crew. My sociological task is to study the practices and artistic decision-making in order to make explicit the social contexts of this activity. I will explain these discursive and pragmatic practices with the thematic content analysis of 20 interviews to participants of a TV production set. Thanks to the ATLAS.ti I defined the social practices that make the reproduction of social distinction possible. Qualitative analysis has made polivalent terms such as habitus and capital (Bourdieu, 1979; 1994; 1998, otherwise too ambiguous to be applied empirically, more specific. The legitimacy of artistic decision-making arises from a type of artistic habitus, which we defined as the “TV habitus”. The interviewees consider the relational and

Characteristics of motorized spindle supported by active magnetic bearings

Directory of Open Access Journals (Sweden)

Xie Zhenyu

2014-12-01

Full Text Available A motorized spindle supported by active magnetic bearings (AMBs is generally used for ultra-high-speed machining. Iron loss of radial AMB is very great owing to high rotation speed, and it will cause severe thermal deformation. The problem is particularly serious on the occasion of large power application, such as all electric aero-engine. In this study, a prototype motorized spindle supported by five degree-of-freedom AMBs is developed. Homopolar and heteropolar AMBs are independently adopted as radial bearings. The influences of the two types of radial AMBs on the dynamic characteristics of the motorized spindle are comparatively investigated by theoretical analysis, test modal analysis and actual operation of the system. The iron loss of the two types of radial AMBs is analyzed by finite element software and verified through run-down experiments of the system. The results show that the structures of AMB have less influence on the dynamic characteristics of the motorized spindle. However, the homopolar structure can effectively reduce the iron loss of the radial AMB and it is useful for improving the overall performance of the motorized spindle.

Targeting the oxidative stress response system of fungi with safe, redox-potent chemosensitizing agents

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Jong H. eKim

2012-03-01

Full Text Available The cellular antioxidation system is a target in the antifungal action of amphotericin B (AMB and itraconazole (ITZ, in filamentous fungi. The sakAΔ mutant of Aspergillus fumigatus, a mitogen-activated protein kinase (MAPK gene deletion mutant in the antioxidation system, was found to be more sensitive to AMB or ITZ than other A. fumigatus strains, a wild type and a mpkCΔ mutant (MAPK gene deletion mutant in polyalcohol sugar utilization system. The sakAΔ mutant showed no growth at 0.5 μg mL-1 of ITZ or reduced growth at 1.0 to 2.0 μg mL-1 of AMB, while the other strains exhibited robust growth. Complete fungal kill (≥ 99.9% by ITZ or AMB was achieved by much lower dosages for the sakAΔ mutant than for the other strains. SakA and MpkC appear to have overlapping roles in marshalling the oxidative stress response under treatment by an organic peroxide, tert-butyl hydroperoxide (t-BuOOH, or hydrogen peroxide (H2O2. The SakA signalling pathway was found to be responsible for fungal tolerance to AMB or ITZ toxicity. It appears msnA, an Aspergillus ortholog to Saccharomyces cerevisiae MSN2 (encoding a stress-responsive C2H2-type zinc-finger regulator and sakA and/or mpkC (upstream MAPKs are in the same stress response network under t-BuOOH-, H2O2- or AMB-triggered toxicity. Of note is that ITZ-sensitive yeast pathogens (Candida krusei and Cryptococcus neoformans were also sensitive to t-BuOOH, showing a connection between ITZ toxicity and oxidative stress response. This was shown by enhanced antifungal activity of AMB or ITZ when co-applied with redox-potent natural compounds, 2,3-dihydroxybenzaldehyde, thymol or salicylaldehyde, as chemosensitizing agents. Hence, redox compounds, which target the antioxidation system in fungi, possess a potent chemosensitizing capacity to enhance efficacy of conventional drugs inducing oxidative stress. Such chemosensitization can reduce costs and alleviate negative side effects associated with current

Amphotericin B, alone or followed by itraconazole therapy, is effective in the control of experimental disseminated sporotrichosis by Sporothrix brasiliensis.

Science.gov (United States)

Ishida, Kelly; de Castro, Rafaela Alves; Borba Dos Santos, Luana Pereira; Quintella, Leonardo Pereira; Lopes-Bezerra, Leila M; Rozental, Sonia

2015-01-01

Sporothrix brasiliensis is a highly virulent member of the S. schenckii complex, which is responsible for the emergence of the epidemic sporotrichosis in southeastern Brazil over the last two decades. There are no in vivo studies on the sensitivity of S. brasiliensis to the therapeutic regimens used to treat sporotrichosis. Here, we evaluated the efficacy and safety of antifungal treatments against S. brasiliensis using a murine model of disseminated sporotrichosis. In vitro, S. brasiliensis yeasts were sensitive to low concentrations of amphotericin B-deoxycholate (AMB-d) and itraconazole (ITZ), the latter having greater selectivity toward the fungus. The following treatment regimens were tested in vivo: intravenous AMB-d for 7 days post-infection (p.i.), oral ITZ for up to 30 days p.i., and AMB-d followed by ITZ (AMB-d/ITZ). AMB-d and AMB-d/ITZ led to 100% survival of infected mice at the end of the 45-day experimental period. Although all treatments extended mice survival, only AMB-d and AMB-d/ITZ significantly reduced fungal load in all organs, but AMB-d/ITZ led to a more consistent decrease in overall fungal burden. No treatment increased the levels of serum toxicity biomarkers. Taken together, our results indicate that AMB-d/ITZ is the best therapeutic option for controlling disseminated sporotrichosis caused by S. brasiliensis. © The Author 2014. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Diet Matters: Endotoxin in the Diet Impacts the Level of Allergic Sensitization in Germ-Free Mice

Czech Academy of Sciences Publication Activity Database

Schwarzer, M.; Šrůtková, Dagmar; Hermanová, Petra; Leulier, F.; Kozáková, Hana; Schabussova, I.

2017-01-01

Roč. 12, č. 1 (2017), s. 1-15, č. článku e0167786. E-ISSN 1932-6203 R&D Projects: GA ČR GA303/09/0449; GA ČR(CZ) GA16-06326S; GA MŠk 7AMB12AT020; GA MŠk 7AMB15AT025 Institutional support: RVO:61388971 Keywords : REGULATORY T-CELLS * BET V 1 * COMMENSAL BACTERIA Subject RIV: EC - Immunology OBOR OECD: Immunology Impact factor: 2.806, year: 2016

Pickering emulsion stabilized by cashew gum- poly-l-lactide copolymer nanoparticles: Synthesis, characterization and amphotericin B encapsulation.

Science.gov (United States)

Richter, A R; Feitosa, J P A; Paula, H C B; Goycoolea, F M; de Paula, R C M

2018-04-01

In this work, we provide proof-of-concept of formation, physical characteristics and potential use as a drug delivery formulation of Pickering emulsions (PE) obtained by a novel method that combines nanoprecipitation with subsequent spontaneous emulsification process. To this end, pre-formed ultra-small (d.∼10 nm) nanoprecipitated nanoparticles of hydrophobic derivatives of cashew tree gum grafted with polylactide (CGPLAP), were conceived to stabilize Pickering emulsions obtained by spontaneous emulsification. These were also loaded with Amphotericin B (AmB), a drug of low oral bioavailability used in the therapy of neglected diseases such as leishmaniasis. The graft reaction was performed in two CG/PLA molar ratio conditions (1:1 and 1:10). Emulsions were prepared by adding the organic phase (Miglyol 812 ® ) in the aqueous phase (nanoprecipitated CGPLAP), resulting the immediate emulsion formation. The isolation by centrifugation does not destabilize or separate the nanoparticles from oil droplets of the PE emulsion. Emulsions with CGPLAP 1:1 presented unimodal distributions at different CGPLA concentration, lower values in size and PDI and the best stability over time. The AmB was incorporated in the emulsions with a process efficiency of 21-47%, as determined by UV-vis. AmB in CGPLAP emulsions is in less aggregated state than observed in commercial AmB formulation. Copyright © 2018 Elsevier B.V. All rights reserved.

Physical characterization and in vivo pharmacokinetic study of self-assembling amphotericin B-loaded lecithin-based mixed polymeric micelles

Science.gov (United States)

Chen, Ying-Chen; Su, Chia-Yu; Jhan, Hua-Jun; Ho, Hsiu-O; Sheu, Ming-Thau

2015-01-01

To alleviate the inherent problems of amphotericin B (AmB), such as poor water solubility and nephrotoxicity, a novel self-assembling mixed polymeric micelle delivery system based on lecithin and combined with amphiphilic polymers, Pluronic®, Kolliphor®, d-alpha tocopheryl polyethylene glycol succinate, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy(poly(ethylene glycol)-2000 (DSPE-PEG2K) was developed. An optimal formulation (Ambicelles) composed of AmB:lecithin:DSPE-PEG2K in a 1:1:10 weight ratio was obtained. The particle size, polydispersion index, drug encapsulation efficiency, and drug loading were 187.20±10.55 nm, 0.51±0.017, 90.14%, and 7.51%, respectively, and the solubility was increased from 0.001 to 5 mg/mL. Compared with that of Fungizone®, the bioavailability of Ambicelles administered intravenously and orally increased 2.18- and 1.50-fold, respectively. Regarding the in vitro cytotoxicity, Ambicelles had a higher cell viability than free AmB solution or Fungizone® did. With pretreatment of 50 μg/mL ethanolic extract of Taiwanofungus camphoratus followed by AmB to HT29 colon cancer cells, the 50% inhibitory concentration of AmB solution was 12 μg/mL, whereas that of Ambicelles was 1 μg/mL, indicating that Ambicelles exerted a greater synergistic anticancer effect. PMID:26664117

Physical characterization and in vivo pharmacokinetic study of self-assembling amphotericin B-loaded lecithin-based mixed polymeric micelles.

Science.gov (United States)

Chen, Ying-Chen; Su, Chia-Yu; Jhan, Hua-Jun; Ho, Hsiu-O; Sheu, Ming-Thau

2015-01-01

To alleviate the inherent problems of amphotericin B (AmB), such as poor water solubility and nephrotoxicity, a novel self-assembling mixed polymeric micelle delivery system based on lecithin and combined with amphiphilic polymers, Pluronic(®), Kolliphor(®), d-alpha tocopheryl polyethylene glycol succinate, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy(poly(ethylene glycol)-2000 (DSPE-PEG2K) was developed. An optimal formulation (Ambicelles) composed of AmB:lecithin:DSPE-PEG2K in a 1:1:10 weight ratio was obtained. The particle size, polydispersion index, drug encapsulation efficiency, and drug loading were 187.20±10.55 nm, 0.51±0.017, 90.14%, and 7.51%, respectively, and the solubility was increased from 0.001 to 5 mg/mL. Compared with that of Fungizone(®), the bioavailability of Ambicelles administered intravenously and orally increased 2.18- and 1.50-fold, respectively. Regarding the in vitro cytotoxicity, Ambicelles had a higher cell viability than free AmB solution or Fungizone(®) did. With pretreatment of 50 μg/mL ethanolic extract of Taiwanofungus camphoratus followed by AmB to HT29 colon cancer cells, the 50% inhibitory concentration of AmB solution was 12 μg/mL, whereas that of Ambicelles was 1 μg/mL, indicating that Ambicelles exerted a greater synergistic anticancer effect.

Guia per al càlcul simplificat de corbes de valoració

OpenAIRE

Núñez Burcio, Oscar; Serrano i Plana, Núria; Subirats i Vila, Xavier

2016-01-01

La guia descriu com calcular corbes de valoració d'acids i bases, utilitzant simplificacions, a partir de la seva concentració i de les constants de dissociació. Els casos presentats són els següents: - Valoració d’un àcid fort amb una base forta - Valoració d’una base forta amb un àcid fort - Valoració d’un àcid feble monopròtic amb una base forta - Valoració d’una base feble monopròtica amb un àcid fort - Valoració d’un àcid feble dipròtic amb una base forta - Valoració d...

Mild heating of amphotericin B-desoxycholate: effects on ultrastructure, in vitro activity and toxicity, and therapeutic efficacy in severe candidiasis in leukopenic mice

NARCIS (Netherlands)

E.W.M. van Etten (Els); W. van Vianen (Wim); P. Roovers; P.M. Frederik

2000-01-01

textabstractHeated (20 min at 70 degrees C) amphotericin B-desoxycholate (hAMB-DOC) was further characterized, as was another formulation obtained after centrifugation (60 min, 3000 x g), hcAMB-DOC. Conventional AMB-DOC consisted of individual micelles (approximately 4

Bubble detectors as a tool of the dosimetry and microdosimetry in neutron fields

International Nuclear Information System (INIS)

Spurny, F.; Vlcek, B.; Rannou, A.

1998-01-01

Two types of bubble detector were studied: the Bubble Damage Neutron Detector (BDND) and the Superheated Drop Detector (SDD). The detectors were tested in neutron beams and fields. The relative response of the detectors varied with the average neutron energy. The response of SDD 100 started to decrease at higher energies than for BDND's, at 100 keV it was only about 1/4 of the response to AmBe neutrons. The responses of SDD 1000 and SDD 6000 decreased with the average neutron energy in a rather similar way. Starting from the AmLi source they represented less than 0.1 of the response to AmBe neutrons. Their response to high energy neutrons was practically the same as to AmBe neutrons. This is important for individual air crew dosimetry on board aircraft. (M.D.)

Peptide stabilized amphotericin B nanodisks

Science.gov (United States)

Tufteland, Megan; Pesavento, Joseph B.; Bermingham, Rachelle L.; Hoeprich, Paul D.; Ryan, Robert O.

2007-01-01

Nanometer scale apolipoprotein A-I stabilized phospholipid disk complexes (nanodisks; ND) have been formulated with the polyene antibiotic amphotericin B (AMB). The present studies were designed to evaluate if a peptide can substitute for the function of the apolipoprotein component of ND with respect to particle formation and stability. An 18-residue synthetic amphipathic α-helical peptide, termed 4F (Ac-D-W-F-K-A-F-Y-D-K-V-A-E-K-F-K-E-A-F-NH2), solubilized vesicles comprised of egg phosphatidylcholine (egg PC), dipentadecanoyl PC or dimyristoylphosphatidylcholine (DMPC) at rates greater than or equal to solubilization rates observed with human apolipoprotein A-I (apoA-I; 243 amino acids). Characterization studies revealed that interaction with DMPC induced a near doubling of 4F tryptophan fluorescence emission quantum yield (excitation 280 nm) and a ~7 nm blue shift in emission wavelength maximum. Inclusion of AMB in the vesicle substrate resulted in formation of 4F AMB-ND. Spectra of AMB containing particles revealed the antibiotic is a highly effective quencher of 4F tryptophan fluorescence emission, giving rise to a Ksv = 7.7 × 104. Negative stain electron microscopy revealed that AMB-ND prepared with 4F possessed a disk shaped morphology similar to ND prepared without AMB or prepared with apoA-I. In yeast and pathogenic fungi growth inhibition assays, 4F AMB-ND was as effective as apoA-I AMB-ND. The data indicate that AMB-ND generated using an amphipathic peptide in lieu of apoA-I form a discrete population of particles that possess potent biological activity. Given their intrinsic versatility, peptides may be preferred for scale up and clinical application of AMB-ND. PMID:17293004

Metallurgical Laboratory Hazardous Waste Management Facility groundwater monitoring report

International Nuclear Information System (INIS)

Thompson, C.Y.

1993-03-01

During fourth quarter 1992, samples from 18 groundwater monitoring wells of the AMB series at the Metallurgical Laboratory Hazardous Waste Management Facility were analyzed for certain heavy metals, indicator parameters, radionuclides, volatile organic compounds, and other constituents. Six parameters exceeded final Primary Drinking Water Standards (PDWS) and the Savannah River Site Flag 2 criteria during the quarter. The results for fourth quarter 1992 are fairly consistent with the rest of the year's data. Tetrachloroethylene exceeded the final PDWS in well AMB 4D only two of the four quarters; in the other three wells in which it was elevated, it was present at similar levels throughout the year. Trichloroethylene consistently exceeded its PDWS in wells AMB 4A, 4B, 4D, 5, and 7A during the year. Trichloroethylene was elevated in well AMB 6 only during third and fourth quarters and in well AMB 7 only during fourth quarter. Total alpha-emitting radium was above the final PDWS for total radium in well AMB 5 at similar levels throughout the year and exceeded the PDWS during one of the three quarters it was analyzed for (third quarter 1992) in well AMB 10B

La tasca legislativa del Consell d'Europa davant la utilització d'Internet amb finalitats terroristes

Directory of Open Access Journals (Sweden)

Alicia Chicharro Lázaro

2009-12-01

, posades en conjunció, permetran fer front a aquests comportaments delictius: la Convenció sobre Cibercrim de l'any 2001 i la Convenció per a la Prevenció del Terrorisme de l'any 2005. L'adaptació de la legislació interna a aquests instruments proporcionarà als estats una cobertura adequada per a perseguir els crims associats a l'ús d'Internet amb fins terroristes.

Budget impact analysis of liposomal amphotericin B and amphotericin B lipid complex in the treatment of invasive fungal infections in the United States.

Science.gov (United States)

Yang, Hongbo; Chaudhari, Paresh; Zhou, Zheng-Yi; Wu, Eric Q; Patel, Chad; Horn, David L

2014-02-01

Liposomal amphotericin B (L-AMB) and amphotericin B lipid complex (ABLC) are both indicated for treating invasive fungal infections (IFIs) caused by Aspergillus, Candida and Cryptococcus spp. among patients who are refractory to or intolerant of conventional amphotericin B (CAB). Prior studies have suggested similar efficacies but differences in adverse event (AE) profiles between L-AMB and ABLC. Our objective was to conduct a cost-minimisation and budget impact analysis for the treatment of IFIs with L-AMB and ABLC in a US hospital setting. A Microsoft® Excel-based budget impact model was developed to estimate the costs associated with using L-AMB and ABLC for the treatment of adult patients with Aspergillus, Candida and Cryptococcus spp. infections, who are refractory to or intolerant of CAB, during a hospital stay. The model was built from a hospital perspective, and included drug costs of L-AMB and ABLC, and costs for treating drug-related AEs (i.e. nephrotoxicity with/without dialysis, infusion-related reactions, anaphylaxis, hypomagnesaemia and hypokalaemia). Average sales price was used as the drug cost estimate in the base-case analyses. The treatment duration and rates of AEs for L-AMB and ABLC were mainly obtained from a retrospective study of these two drugs in the target population using the Cerner Health Facts data. Treatment costs of AEs were obtained from the publicly available sources. The budget impact ($US, year 2011 values) was evaluated for a hypothetical hospital with 100 administrations where L-AMB and ABLC are used for the treatment of the target population by changing the market share of L-AMB and ABLC from 32/68% to an anticipated market share of 60/40% in the base-case analysis. Sensitivity analyses were conducted by varying drug costs, rates of AEs, costs of AEs and anticipated market shares of L-AMB and ABLC. The estimated per-patient cost per hospital episode associated with L-AMB and ABLC use were $US14,563 and $US16,748, respectively

Monitoratge de la glicèmia en el pacient crític: Protocols d'insulinoterapia intensiva i ús del catèter arterial per a l'extracció de mostres de sang

OpenAIRE

Raurell Torredà, Marta

2013-01-01

Antecedents del tema Posteriorment a l’estudi de Van den Berghe, es van anar aplicant a les diferents UCI’s els protocols de Intensive Insulin Therapy (IIT, insulinoteràpia intensiva) en base a la disminució de la morbimortalitat en pacients tractats amb IIT respecte el tractament amb Conventional Insulin Therapy (CIT, insulinoteràpia subcutània convencional amb sliding-scales). Els protocols de IIT van comportar un increment de la incidència d’hipoglicèmia greu, que es va relacionar amb ...

Determination of amphotericin B in PLA-PEG blend nanoparticles by HPLC-PDA

Directory of Open Access Journals (Sweden)

Caroline Danziato Rodrigues

2014-12-01

Full Text Available In this work, we developed and validated an effective reversed-phase HPLC method with photodiode array (PDA detection for the quantitative analysis of amphotericin B (AmB in poly(lactide-poly(ethylene glycol (PLA-PEG blend nanoparticles. Chromatographic runs were performed on a reverse phase C18 column using a mobile phase comprising a 9% acetic acid and acetonitrile mixture (40:60, v/v under isocratic elution with a flow rate of 1 mL/min. AmB was detected at a wavelength of 408 nm. The validation process was performed considering the selectivity, linearity, precision, accuracy, robustness, limit of detection (LOD and limit of quantitation (LOQ of the method. A concentration range of 1-20 µg/mL was used to construct a linear calibration curve. The LOQ and LOD were 55 and 18 ng/mL, respectively. The mean recovery of AmB from the samples was 99.92% (relative standard deviation (RSD = 0.34%, n=9, and the method was robust for changes in the flow rate of the mobile phase (maximum RSD=4.82%. The intra- and inter-assay coefficients of variation were less than 0.59%. The method was successfully used to determine the entrapment efficiency of AmB in PLA-PEG blend nanoparticles.

Novel approaches to singlet oxygen photosensitization in the nano- and bio-era

OpenAIRE

Planas Marquès, Oriol

2017-01-01

En aquesta tesis es detallen noves aproximacions nano- i biomoleculars amb l’objectiu de millorar la fotosensibilització i detecció d’oxigen singlet en medi biològic. En primer lloc es presenta una nova reacció fluoro- i cromogènica pel marcatge de proteïnes i nanopartícules amb derivats de porficè. Concretament, la reacció de porficens isotiocianat amb amines primàries i secundaries generen 2-aminotiazolo[4,5-c]poricè derivats amb un desplaçament concomitant en els seus espectres d’absor...

Periodismo inmersivo: Fundamentos para una forma periodística basada en la interfaz y la acción

OpenAIRE

Domínguez Martín, Eva Maria

2013-01-01

L'impacte de tecnologies com la realitat virtual juntament amb la influència narrativa dels videojocs han afavorit el que anomenem una retòrica immersiva, una forma de relatar amb recursos visuals i interactius per tal d’aconseguir un alt grau d'immersió de l'usuari. Entenem per periodisme immersiu una pràctica periodística emergent que aplica les tecnologies i recursos necessaris amb aquest objectiu. Per bé que el periodisme immersiu té la seva expressió màxima amb l'aplicació de la tecnolog...

Xarxes educatives 2.1. Mitjans socials, entorns col·laboratius i processos d'ensenyament i aprenentatge

OpenAIRE

Levis, Diego; Diéguez, Sol; Rey, Eugenia

2011-01-01

El projecte Xarxes Educatives 2.1 es proposa indagar les possibilitats que ofereixen els mitjans socials i els entorns col·laboratius a internet en els processos d'ensenyament i aprenentatge. Per a això, en cursos presencials i en cursos de capacitació docent de modalitat semipresencial fem servir una aplicació de la web 2.0 destinada a la creació de xarxes socials. L'aplicació es va configurar d'acord amb els objectius pedagògics de cada un dels cursos inclosos en el projecte. Es va establir...

Spectroscopic investigation of the aggregation state of amphotericin B during loading, freeze-drying, and reconstitution of polymeric micelles.

Science.gov (United States)

Adams, Monica; Kwon, Glen S

2004-11-22

To investigate the relative aggregation state of amphotericin B (AmB) during loading and reconstitution of polymeric micelles. Hexanoate and stearate derivatives of PEO-b-p (L-Asp) were prepared. The polymers and AmB were dissolved in methanol (MeOH). Milli-Q water was then added slowly, and the MeOH was removed via rotary evaporation. The solutions were freeze-dried in the presence of trehalose. During micelle preparation, the aggregation state of AmB was assessed using absorption spectroscopy. Upon reconstitution, the samples were analyzed using vapor-pressure osmometry, size-exclusion chromatography (SEC), and absorption spectroscopy. The absorption spectrum of AmB in the presence of the block copolymers was compared to that of AmB alone under the same conditions. AmB was loaded into micelles prepared from acyl derivatives of PEO-b-p (L-Asp). Absorption spectroscopy indicated that the aggregation state was preserved during the loading process. AmB exists in a self-aggregated state in polymeric micelles containing hexanoate ester cores and in a relatively monomeric state in polymeric micelles containing stearate ester cores. Vapor-pressure osmometry confirmed the isotonicity of the formulations, while SEC indicated that the micelles were approximately 10(6) g/mol. Depending on the polymer structure and assembly conditions, it is possible to encapsulate AmB in a relatively nonaggregated or aggregated state in micelles prepared from acyl derivatives of PEO-b-p (L-Asp). In polymeric micelles containing stearate side chains, AmB was loaded in a nearly monomeric state, possibly due to interaction with the stearate side chains. The final aggregation state of the drug is preserved during lyophilization and reconstitution of polymeric micelles prepared by a novel solvent evaporation procedure.

Quantitative and qualitative analysis of the antifungal activity of allicin alone and in combination with antifungal drugs.

Directory of Open Access Journals (Sweden)

Young-Sun Kim

Full Text Available The antifungal activity of allicin and its synergistic effects with the antifungal agents flucytosine and amphotericin B (AmB were investigated in Candida albicans (C. albicans. C. albicans was treated with different conditions of compounds alone and in combination (allicin, AmB, flucytosine, allicin + AmB, allicin + flucytosine, allicin + AmB + flucytosine. After a 24-hour treatment, cells were examined by scanning electron microscopy (SEM and atomic force microscopy (AFM to measure morphological and biophysical properties associated with cell death. The clearing assay was conducted to confirm the effects of allicin. The viability of C. albicans treated by allicin alone or with one antifungal drug (AmB, flucytosine in addition was more than 40% after a 24-hr treatment, but the viability of groups treated with combinations of more than two drugs was less than 32%. When the cells were treated with allicin alone or one type of drug, the morphology of the cells did not change noticeably, but when cells were treated with combinations of drugs, there were noticeable morphological changes. In particular, cells treated with allicin + AmB had significant membrane damage (burst or collapsed membranes. Classification of cells according to their cell death phase (CDP allowed us to determine the relationship between cell viability and treatment conditions in detail. The adhesive force was decreased by the treatment in all groups compare to the control. Cells treated with AmB + allicin had a greater adhesive force than cells treated with AmB alone because of the secretion of molecules due to collapsed membranes. All cells treated with allicin or drugs were softer than the control cells. These results suggest that allicin can reduce MIC of AmB while keeping the same efficacy.

Intraspecies differences in natural susceptibility to amphotericine B of clinical isolates of Leishmania subgenus Viannia.

Directory of Open Access Journals (Sweden)

Carlos Franco-Muñoz

Full Text Available Amphotericin B (AmB is a recommended medication for the treatment of cutaneous and mucosal leishmaniasis in cases of therapeutic failure with first-line medications; however, little is known about the in vitro susceptibility to AmB of clinical isolates of the subgenus Viannia, which is most prevalent in South America. This work aimed to determine the in vitro susceptibility profiles to AmB of clinical isolates of the species L. (V. panamensis, L. (V. guyanensis and L. (V. braziliensis. In vitro susceptibility to AmB was evaluated for 65 isolates. Macrophages derived from the U937 cell line were infected with promastigotes and exposed to different AmB concentrations. After 96 hours, the number of intracellular amastigotes was quantified by qPCR, and median effective concentration (EC50 was determined using the PROBIT model. The controls included sensitive strains and experimentally derived less sensitive strains generated in vitro, which presented EC50 values up to 7.57-fold higher than the values of the sensitive strains. The isolates were classified into groups according to their in vitro susceptibility profiles using Ward's hierarchical method. The susceptibility to AmB differed in an intraspecies-specific manner as follows: 28.21% (11/39 of L. (V. panamensis strains, 50% (3/6 of L. (V. guyanensis strains and 34.61% (9/26 of L. (V. braziliensis strains were classified as less sensitive. The latter subset featured three susceptibility groups. We identified Colombian isolates with different AmB susceptibility profiles. In addition, the capacity of species of subgenus Viannia to develop lower susceptibility to AmB was demonstrated in vitro. These new findings should be considered in the pharmacovigilance of AmB in Colombia and South America.

Metodologia

OpenAIRE

Carreras i Quilis, Josep Maria

2009-01-01

En aquest article s'expliciten els procediments metodològics que s'han utilitzat per determinar els 10.630 municipis urbans i les 104 aglomeracions metropolitanes europees. També s'hi fa una comparació amb els resultats amb l'edició de 2002 i amb els d'altres estudis de referència.

Source term determination from subcritical multiplication measurements at Koral-1 reactor

International Nuclear Information System (INIS)

Blazquez, J.B.; Barrado, J.M.

1978-01-01

By using an AmBe neutron source two independent procedures have been settled for the zero-power experimental fast-reactor Coral-1 in order to measure the source term which appears in the point kinetical equations. In the first one, the source term is measured when the reactor is just critical with source by taking advantage of the wide range of the linear approach to critical for Coral-1. In the second one, the measurement is made in subcritical state by making use of the previous calibrated control rods. Several applications are also included such as the measurement of the detector dead time, the determinations of the reactivity of small samples and the shape of the neutron importance of the source. (author)

Posaconazole Enhances the Activity of Amphotericin B against Aspergillus Hyphae In Vitro▿

OpenAIRE

Perkhofer, Susanne; Lugger, Helene; Dierich, Manfred P.; Lass-Flörl, Cornelia

2006-01-01

The MICs and fractional inhibitory concentrations of posaconazole (POS) and voriconazole (VRZ), alone and in combination with amphotericin B (AMB), for the conidia and hyphae of 100 Aspergillus isolates were evaluated. POS-AMB had more synergistic activity against hyphae (75% of isolates) than VRZ-AMB (37%) and significantly more synergistic activity against hyphae than against conidia (12%).

Concurrent use of magnetic bearings for rotor support and force sensing for the nondestructive evaluation of manufacturing processes

Science.gov (United States)

Kasarda, Mary; Imlach, Joseph; Balaji, P. A.; Marshall, Jeremy T.

2000-06-01

Active magnetic bearings are a proven technology in turbomachinery applications and they offer considerable promise for improving the performance of manufacturing processes. The Active Magnetic Bearing (AMB) is a feedback mechanism that supports a spinning shaft by levitating it in a magnetic field. AMBs have significantly higher surface speed capability than rolling element bearings and they eliminate the potential for product contamination by eliminating the requirement for bearing lubrication. In addition, one of the most promising capabilities for manufacturing applications is the ability of the AMB to act concurrently as both a support bearing and non-invasive force sensor. The feedback nature of the AMB allows for its use as a load cell to continuously measure shaft forces necessary for levitation based on information about the magnetic flux density in the air gaps. This measurement capability may be exploited to improve the process control of such products as textile fibers and photographic films where changes in shaft loads may indicate changes in product quality. This paper discusses the operation of AMBs and their potential benefits in manufacturing equipment along with results from research addressing accurate AMB force sensing performance in field applications. Specifically, results from the development of enhanced AMB measurement algorithms to better account for magnetic fringing and leakage effects to improve the accuracy of this technique are presented. Results from the development of a new on-line calibration procedure for robust in-situ calibration of AMBs in a field application such as a manufacturing plant scenario are also presented including results of Magnetic Finite Element Analysis (MFEA) verification of the procedure.

Study of resistance to deformation dependence on temperature and strain degree during working with different rates for ABM-1 alloy

International Nuclear Information System (INIS)

Kharlamov, V.V.; Dvinskij, V.M.; Vashlyaev, Eh.V.; Dyblenko, Z.A.; Khamatov, R.I.; Zverev, K.P.

1981-01-01

On the basis of approximation of the experimental curves partial differential equations relating ABM-1 alloy deformation resistance to the deformation parameters are obtained. Using statistical processing of the experimental data the regression equations of the dependence of the deformation resistance on temperature rate and relative reduction of the samples are found. In the 2.1-23.6 1/c deformation rate range hardening and weakening rates of the AMB-1 alloy increases with the increase of the latter. The data obtained permit to calculate the deformation parameters of the studied alloy for different processes of metal plastic working in the studied temperature range [ru

Pharmacophore modeling for COX-1 and-2 inhibitors with LigandScout in comparison to Discovery Studio

Czech Academy of Sciences Publication Activity Database

Temml, V.; Kaserer, T.; Kutil, Zsófia; Landa, Přemysl; Vaněk, Tomáš; Schuster, D.

2014-01-01

Roč. 6, č. 17 (2014), s. 1869-1881 ISSN 1756-8919 R&D Projects: GA MŠk 7AMB13AT008 Institutional support: RVO:61389030 Keywords : CYCLOOXYGENASE INHIBITION * DRUG DESIGN * SELECTIVE-INHIBITION Subject RIV: EC - Immunology Impact factor: 3.744, year: 2014

The contribution of work satisfaction to the life satisfaction of chilean workers

OpenAIRE

Loewe Pujol-Xicoy, Nicolás

2015-01-01

Aquesta tesi se centra en el concepte de la satisfacció amb la vida en el context de Xile. Després de revisar múltiples factors que influeixen sobre el nivell de satisfacció general amb la vida de les persones, es proposa un model de satisfacció amb la vida basat en el nivell de satisfacció amb múltiples aspectes importants de la vida com són la salut, la família i la feina. Comparant la importància que els treballadors xilens atorguen a cadascun d'aquests aspectes, aquesta tesi contribueix a...

Aplicación de un score semiquantitativo de tac-ar para el control y evaluación del pronóstico de pacientes con fibrosis pulmonar idiopática

OpenAIRE

Peris i Sanchez, Ricardo

2012-01-01

Estudi prospectiu amb 36 pacients, on definírem un score semiquantitatiu per a diferents patrons de FPI a la TCAR, i la suma resultant (Score Total). Estudiàrem la relació amb paràmetres funcionals i cel.lularitat del RBA, analitzant-se'n les diferències amb els pacients morts. Trobàrem correlació entre el score de bresca (honeycomb) i total amb alguns paràmetres funcionals, prova de marxa de 6 minuts i la gasometria arterial. Els morts hi tenien major score total i tendència a la neutrofília...

Design of amphotericin B oral formulation for antifungal therapy.

Science.gov (United States)

Liu, Min; Chen, Meiwan; Yang, Zhiwen

2017-11-01

Amphotericin B (AmB) remains the "gold standard" for systemic antifungal therapy, even though new drugs are emerging as the attractive antifungal agents. Since AmB has negligible oral absorption as a consequence of its unfavorable physicochemical characterizations, its use is restricted to parenteral administration which is accompanied by severe side effects. As greater understanding of the gastrointestinal tract has developed, the advanced drug delivery systems are emerging with the potential to overcome the barriers of AmB oral delivery. Much research has demonstrated that oral AmB formulations such as lipid formulations may have beneficial therapeutic efficacy with reduced adverse effects and suitable for clinical application. Here we reviewed the different formulation strategies to enhance oral drug efficacy, and discussed the current trends and future perspectives for AmB oral administration in the treatment of antifungal infections.

L-Asparaginase of Leishmania donovani: Metabolic target and its role in Amphotericin B resistance

Directory of Open Access Journals (Sweden)

Jasdeep Singh

2017-12-01

Full Text Available Emergence of Amphotericin B (AmB resistant Leishmania donovani has posed major therapeutic challenge against the parasite. Consequently, combination therapy aimed at multiple molecular targets, based on proteome wise network analysis has been recommended. In this regard we had earlier identified and proposed L-asparaginase of Leishmania donovani (LdAI as a crucial metabolic target. Here we report that both LdAI overexpressing axenic amastigote and promastigote forms of L. donovani survives better when challenged with AmB as compared to wild type strain. Conversely, qRT-PCR analysis showed an upregulation of LdAI in both forms upon AmB treatment. Our data demonstrates the importance of LdAI in imparting immediate protective response to the parasite upon AmB treatment. In the absence of structural and functional information, we modeled LdAI and validated its solution structure through small angle X-ray scattering (SAXS analysis. We identified its specific inhibitors through ligand and structure-based approach and characterized their effects on enzymatic properties (Km, Vmax, Kcat of LdAI. We show that in presence of two of the inhibitors L1 and L2, the survival of L. donovani is compromised whereas overexpression of LdAI in these cells restores viability. Taken together, our results conclusively prove that LdAI is a crucial metabolic enzyme conferring early counter measure against AmB treatment by Leishmania. Keywords: Leishmania donovani, L-asparaginase, Amphotericin B resistance, Metabolic target

[A Matter of Balance: strategy for implementation in Dutch homecare organizations].

Science.gov (United States)

de Jonge, M C; van der Poel, A; van Haastregt, J C M; Du Moulin, M F T M; Zijlstra, G A R; Voordouw, I

2013-02-01

The Dutch version of A Matter of Balance (AMB-NL) is a cognitive behavioral group program to reduce fear of falling and related activity avoidance in community-living older persons. This paper presents the strategy for implementation of AMB-NL in Dutch homecare organizations and the outcomes of this implementation. The aim was to implement AMB-NL in at least 50 % of 64 homecare organizations in The Netherlands in 2009 and 2010. The implementation strategy was based on the four phases of the Replicating Effective Interventions: pre-conditions, pre-implementation, implementation, and maintenance and evolution. After preparing the implementation activities, such as identifying implementation barriers, consulting stakeholders, preparing the materials involved in the implementation, and training the facilitators of the program (n = 53), AMB-NL was implemented in 16 of the 64 homecare organizations (25 %). Another five homecare organizations indicated that they would shortly include AMB-NL in their care program. These organizations conducted the intervention 19 times to a total of 178 participants. After the implementation phase another 16 facilitators were trained, and program materials were successfully disseminated. The implementation of AMB-NL was well performed. The targeted aim is not fully reached within the two-year timeframe, but the program is well received by participants, trainers and homecare organizations. Further implementation and maintenance of AMB-NL in primary health care is recommended.

Evaluating the potential of cubosomal nanoparticles for oral delivery of amphotericin B in treating fungal infection

Directory of Open Access Journals (Sweden)

Yang Z

2014-01-01

Full Text Available Zhiwen Yang,1,3 Meiwan Chen,2 Muhua Yang,1 Jian Chen,1 Weijun Fang,1 Ping Xu11Department of Pharmacy, Songjiang Hospital Affiliated The First People's Hospital, Shanghai Jiao Tong University, Shanghai, 2State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 3Shanghai Songjiang Hospital Affiliated Nanjing Medical University, Nanjing, People's Republic of ChinaAbstract: The oral administration of amphotericin B (AmB has a major drawback of poor bioavailability. The aim of this study was to investigate the potential of glyceryl monoolein (GMO cubosomes as lipid nanocarriers to improve the oral efficacy of AmB. Antifungal efficacy was determined in vivo in rats after oral administration, to investigate its therapeutic use. The human colon adenocarcinoma cell line (Caco-2 was used in vitro to evaluate transport across a model of the intestinal barrier. In vivo antifungal results showed that AmB, loaded in GMO cubosomes, could significantly enhance oral efficacy, compared against Fungizone®, and that during a 2 day course of dosage 10 mg/kg the drug reached effective therapeutic concentrations in renal tissue for treating fungal infections. In the Caco-2 transport studies, GMO cubosomes resulted in a significantly larger amount of AmB being transported into Caco-2 cells, via both clathrin- and caveolae-mediated endocytosis, but not macropinocytosis. These results suggest that GMO cubosomes, as lipid nanovectors, could facilitate the oral delivery of AmB.Keywords: glyceryl monoolein cubosomes, oral delivery, amphotericin B, antifungal activity, absorption mechanism

Study on the controllability for active magnetic bearings

International Nuclear Information System (INIS)

Jiang, Z F; Wu, H C; Lu, H; Li, C R

2005-01-01

One of the main challenges in AMB is its controllability which means it is difficult to get a stable spindle and controller. To solve this problem, some methods have been developed previously, but the value of the controllability of AMB was not calculated. The subject of our study is to develop a new method and find a mathematical model that aims to research the controllability of AMB, the status at passing through levitation process, running, a critical speed and achieve high-speed rotation. The stiffness and damping of AMB, which changes randomly along with the rotor running, are determined by the controller system. How to get the relationship between the stiffness and damping with dynamic coefficients of rotor-AMB system is a key problem to get an optimization controller. In this paper, a mathematical model of the relationship is established. Stiffness and damping of AMB can change if the parameter of controller modulated. Based on rotor dynamics theory, the dynamic characteristics of rotors such as critical speeds, system stability and unbalanced excitation are analyzed. Computer simulations are carried out and the effectiveness of the presented procedure is investigated

Amphotericin B releasing topical nanoemulsion for the treatment of candidiasis and aspergillosis.

Science.gov (United States)

Sosa, Lilian; Clares, Beatriz; Alvarado, Helen L; Bozal, Nuria; Domenech, Oscar; Calpena, Ana C

2017-10-01

The present study was designed to develop a nanoemulsion formulation of Amphotericin B (AmB) for the treatment of skin candidiasis and aspergillosis. Several ingredients were selected on the basis of AmB solubility and compatibility with skin. The formulation that exhibited the best properties was selected from the pseudo-ternary phase diagram. After physicochemical characterization its stability was assessed. Drug release and skin permeation studies were also accomplished. The antifungal efficacy and skin tolerability of developed AmB nanoemulsion was demonstrated. Finally, our results showed that the developed AmB formulation could provide an effective local antifungal effect without theoretical systemic absorption, based on its skin retention capacity, which might avoid related side effect. These results suggested that the nanoemulsion may be an optimal therapeutic alternative for the treatment of skin fungal infections with AmB. Copyright © 2017 Elsevier Inc. All rights reserved.

Proportions of myosin heavy chain mRNAs, protein isoforms and fiber types in the slow and fast skeletal muscles are maintained after alterations of thyroid status in rats

Czech Academy of Sciences Publication Activity Database

Soukup, Tomáš; Diallo, Michael

2015-01-01

Roč. 64, č. 1 (2015), s. 111-118 ISSN 0862-8408 R&D Projects: GA ČR(CZ) GA304/08/0256; GA MŠk(CZ) 7AMB12SK158; GA MŠk(CZ) 7AMB14SK123; GA MŠk(CZ) EE2.3.30.0025 Grant - others:EC(XE) LSH-CT-2004-511978 Institutional support: RVO:67985823 Keywords : thyroid hormones * muscle gene expression * MyHC isoforms and muscle fiber types * quantitative real time RT-PCR * SDS-PAGE and 2-D Stereological analysis Subject RIV: EA - Cell Biology Impact factor: 1.643, year: 2015

Anàlisi i integració de models de programació paral·lels en SoC Tegra 2

OpenAIRE

Prat Robles, David

2011-01-01

Anàlisi i integració de models de programació paral.lels en SoC Tegra 2 Instal·lació Linux i verificació del funcionament Benchmarks amb altres processadors Escalabilitat de Pthreads VS OpenMP Muntatge del clúster amb MPI Mesures des la xarxa Ethernet Portar StarSs amb NANOS++ a ARMv7 Mesures de consum i temperatura Conclusions i prediccions

Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity

Czech Academy of Sciences Publication Activity Database

Kutil, Zsófia; Temml, V.; Maghradze, D.; Přibylová, Marie; Dvořáková, Marcela; Schuster, D.; Vaněk, Tomáš; Landa, Přemysl

2014-01-01

Roč. 2014, UNSP 178931 (2014) ISSN 0962-9351 R&D Projects: GA MŠk(CZ) LD11005; GA MŠk 7AMB13AT008 Institutional support: RVO:61389030 Keywords : HEART - DISEASE * PLATELET-AGGREGATION * CARDIOVASCULAR- DISEASE Subject RIV: GM - Food Processing Impact factor: 3.236, year: 2014

Efficacy of intravenous amphotericin B-polybutylcyanoacrylate nanoparticles against cryptococcal meningitis in mice

Directory of Open Access Journals (Sweden)

Chen JH

2011-04-01

Full Text Available Nan Xu1,2, Julin Gu3, Yuanjie Zhu3, Hai Wen3, Qiushi Ren1, Jianghan Chen31Institute for Laser Medicine and Biophotonics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People's Republic of China; 2Department of Dermatology, Shanghai East Hospital, Shanghai, People's Republic of China; 3Department of Dermatology, Shanghai Changzheng Hospital, Shanghai, People's Republic of ChinaAbstract: Amphotericin B deoxycholate (AmB, a classic antifungal drug, remains the initial treatment of choice for deep fungal infections, but it is not appropriate for treatment of cryptococcal meningitis due to its inability to pass through the blood–brain barrier (BBB. We examined the efficacy of amphotericin B-polybutylcyanoacrylate nanoparticles (AmB-PBCA-NPs modified with polysorbate 80 that had a mean particle diameter less than 100 nanometers (69.0 ± 28.6 nm. AmB-PBCA-NPs were detected in the brain 30 minutes after systemic administration into BALB/c mice and had a higher concentration than systemically administered AmB liposome (AmB-L, P < 0.05; AmB was not detected in the brain. Following infection for 24 hours and then 7 days of treatment, the survival rate of mice in the AmB-PBCA-NP group (80% was significantly higher than that of the AmB (0% or AmB-L (60% treatment groups. Fungal load was also lower when assessed by colony-forming unit counts obtained after plating infected brain tissue (P < 0.05. Our study indicates that AmB-PBCA-NPs with polysorbate 80 coating have the capacity to transport AmB across the BBB and is an efficient treatment against cryptococcal meningitis in a mouse model.Keywords: cryptococcal meningitis, polybutylcyanoacrylate (PBCA, nanoparticles, brain targeting

Physical characterization and in vivo pharmacokinetic study of self-assembling amphotericin B-loaded lecithin-based mixed polymeric micelles

Directory of Open Access Journals (Sweden)

Chen YC

2015-12-01

Full Text Available Ying-Chen Chen,* Chia-Yu Su,* Hua-Jun Jhan, Hsiu-O Ho, Ming-Thau Sheu School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan *These authors contributed equally to this work Abstract: To alleviate the inherent problems of amphotericin B (AmB, such as poor water solubility and nephrotoxicity, a novel self-assembling mixed polymeric micelle delivery system based on lecithin and combined with amphiphilic polymers, Pluronic®, Kolliphor®, d-alpha tocopheryl polyethylene glycol succinate, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy(poly(ethylene glycol-2000 (DSPE-PEG2K was developed. An optimal formulation (Ambicelles composed of AmB:lecithin:DSPE-PEG2K in a 1:1:10 weight ratio was obtained. The particle size, polydispersion index, drug encapsulation efficiency, and drug loading were 187.20±10.55 nm, 0.51±0.017, 90.14%, and 7.51%, respectively, and the solubility was increased from 0.001 to 5 mg/mL. Compared with that of Fungizone®, the bioavailability of Ambicelles administered intravenously and orally increased 2.18- and 1.50-fold, respectively. Regarding the in vitro cytotoxicity, Ambicelles had a higher cell viability than free AmB solution or Fungizone® did. With pretreatment of 50 µg/mL ethanolic extract of Taiwanofungus camphoratus followed by AmB to HT29 colon cancer cells, the 50% inhibitory concentration of AmB solution was 12 µg/mL, whereas that of Ambicelles was 1 µg/mL, indicating that Ambicelles exerted a greater synergistic anticancer effect. Keywords: amphotericin B, micelle, amphiphilic polymer, lecithin, DSPE-PEG

Compartir fitxers amb Dropbox

OpenAIRE

Torres, Begoña; Halbaut, Lyda; Aróztegui Trenchs, Montserrat

2013-01-01

Dropbox és un servei d’allotjament de fitxers en línia, que ens permet emmagatzemar els nostres documents al núvol de manera gratuïta. Es mostra pas a pas com donar-se d'alta al Dropbox i compartir documents.

Comunicacions unificades amb Elastix

OpenAIRE

Martín Jiménez, Alejandro

2016-01-01

The effectiveness of their communications largely determines the success of the company. Today, any technology Officer must make important decisions about the evolution of their systems. Thus, the presence on the market increasingly popular new unified communications products require to consider the various options offered. About this, is proposed to design a solution based on the free software Elastix due to the competitive corporate world offers a cost/performance very important. This proje...

Finite element analysis on the electromagnetic fields of active magnetic bearing

Energy Technology Data Exchange (ETDEWEB)

Ren, S; Liu, J [School of Mechanical Engineering, Shenyang Ligong University, Shenyang, 110168 (China); Bian, C [Institute of Information Science and Engineering, Northeastern University, Shenyang, 110004 (China)], E-mail: renshy@sina.com

2008-02-15

To increase the carrying capacity and reduce the weight and size of AMBs, it is necessary to use a ferromagnetic material with high magnetic flux density, which can make AMBs run in the nonlinear region. The simple linear model before is not gratifying, so some more precise analysis methods are demanded, the finite element method(shorted as FEM) is one of such methods. In this paper, the mathematic model and the simplified calculation of AMB rotor are introduced, and the finite elemental model and its boundary condition are produced. Then, the coupling phenomena of the magnetic fields and the effects of different parameters on the magnetic fields of AMB with a non-homocentric rotor are simulated using the FEM analysis software of ANSYS. The distributions of 2D magnetic lines of force and the flux density in rotor and stator are given. The conclusions are of instructed meaning for the design of AMBs.

Finite element analysis on the electromagnetic fields of active magnetic bearing

International Nuclear Information System (INIS)

Ren, S; Liu, J; Bian, C

2008-01-01

To increase the carrying capacity and reduce the weight and size of AMBs, it is necessary to use a ferromagnetic material with high magnetic flux density, which can make AMBs run in the nonlinear region. The simple linear model before is not gratifying, so some more precise analysis methods are demanded, the finite element method(shorted as FEM) is one of such methods. In this paper, the mathematic model and the simplified calculation of AMB rotor are introduced, and the finite elemental model and its boundary condition are produced. Then, the coupling phenomena of the magnetic fields and the effects of different parameters on the magnetic fields of AMB with a non-homocentric rotor are simulated using the FEM analysis software of ANSYS. The distributions of 2D magnetic lines of force and the flux density in rotor and stator are given. The conclusions are of instructed meaning for the design of AMBs

Monitoring Amphotericin B and Fluconazole Concentrations in the Plasma and Cerebrospinal Fluid of Patients with Cryptococcal Meningitis

Directory of Open Access Journals (Sweden)

Sílvia Regina Cavani Jorge Santos

2012-10-01

Full Text Available Objectives: To determine whether amphotericin B (AmB and fluconazole cross the blood-brain barrier in a similar manner in patients with HIV-associated cryptococcal meningitis based on the cerebrospinal fluid (CSF/plasma drug ratio through a comparative study. Methods: This prospective, open-label clinical protocol included 21 male and female patients, 28-55 years of age. The patients were infected with HIV (CD4 50-200 cells/mL and cryptococcal meningitis and were receiving AmB (1 mg/kg daily, infusion of four hours; 6-10 weeks and fluconazole (400 mg 12 qh; until CSF was negative for fungal growth. The patients were informed in detail about all procedures to be performed in the hospital, including blood and CSF sample collection, if required. The study protocol was approved by the hospital’s ethical committee. Plasma samples were obtained by centrifugation at 2800 g for 30 min, and CSF samples were collected by the physician to relieve symptoms caused by intracranial hypertension. The drug concentrations of both antifungal agents were determined in the biological samples using HPLC. Results: The mean drug plasma: CSF concentrations were 2.30:0.3 μg/mL and 31.7:19.4 μg/mL for AmB and fluconazole, respectively. The CSF:plasma ratios were 0.20 (AmB and 0.67 (fluconazole. Conclusions: Unlike fluconazole, the conventional AmB formulation did not reach the optimum CSF drug concentration. However, a high-dose regimen of fluconazole contributes to the outcome of HIV inpatients with severe cryptococcal meningitis.

Isolation and characterization of Magnetospirillum sp strain 15-1 as a representative anaerobic toluene-degrader from a constructed wetland model

DEFF Research Database (Denmark)

Meyer-Cifuentes, Ingrid; Lavanchy, Paula Maria Martinez; Marin-Cevada, Vianey

2017-01-01

-independent approaches indicated also that microbes capable of anaerobic toluene degradation were abundant. Therefore, we aimed at isolating anaerobic-toluene degraders from one of these PFRs. From the obtained colonies which consisted of spirilli-shaped bacteria, a strain designated 15-1 was selected for further...

Positive in vitro wound healing effects of functional inclusion bodies of a lipoxygenase from the Mexican axolotl.

Science.gov (United States)

Stamm, Anne; Strauß, Sarah; Vogt, Peter; Scheper, Thomas; Pepelanova, Iliyana

2018-04-07

AmbLOXe is a lipoxygenase, which is up-regulated during limb-redevelopment in the Mexican axolotl, Ambystoma mexicanum, an animal with remarkable regeneration capacity. Previous studies have shown that mammalian cells transformed with the gene of this epidermal lipoxygenase display faster migration and wound closure rate during in vitro wound healing experiments. In this study, the gene of AmbLOXe was codon-optimized for expression in Escherichia coli and was produced in the insoluble fraction as protein aggregates. These inclusion bodies or nanopills were shown to be reservoirs containing functional protein during in vitro wound healing assays. For this purpose, functional inclusion bodies were used to coat cell culture surfaces prior cell seeding or were added directly to the medium after cells reached confluence. In both scenarios, AmbLOXe inclusion bodies led to faster migration rate and wound closure, in comparison to controls containing either no AmbLOXe or GFP inclusion bodies. Our results demonstrate that AmbLOXe inclusion bodies are functional and may serve as stable reservoirs of this enzyme. Nevertheless, further studies with soluble enzyme are also necessary in order to start elucidating the exact molecular substrates of AmbLOXe and the biochemical pathways involved in the wound healing effect.

Evolució del marc constitucional de la Unió Europea en la regulació de la inversió estrangera directa

Directory of Open Access Journals (Sweden)

Hector López Bofill

2015-12-01

Full Text Available Amb l’entrada en vigor del Tractat de Lisboa la Unió Europea (UE ha assumit competències en matèria d’inversió estrangera directa. Aquest article descriu el sistema de distribució competencial entre la Unió i els estats membres en aquest àmbit, remarca les competències retingudes pels estats i exercides a través dels tractats bilaterals d’inversió i perfila els instruments que poden fer compatible la política d’inversions de la UE amb la política d’inversions desplegada pels estats. En particular, el text se centra en el desenvolupament de la política de la UE a partir dels nous acords globals d’inversió a punt de ser ratificats o en fase de negociació (com en el cas de l’acord amb el Canadà, de l’acord amb Singapur o de l’acord amb els Estats Units i aprofundeix en les conseqüències derivades de l’establiment d’un sistema de resolució de controvèrsies inversor/estat previst en aquests acords i la seva compatibilitat amb el principi d’autonomia del dret de la UE.

Adaptive Spindle Balancing Using Magnetically Levitated Bearings

International Nuclear Information System (INIS)

BARNEY, PATRICK S.; LAUFFER, JAMES P.; PETTEYS, REBECCA; REDMOND, JAMES M.; SULLIVAN, WILLIAM N.

1999-01-01

A technological break through for supporting rotating shafts is the active magnetic bearing (AMB). Active magnetic bearings offer some important advantages over conventional ball, roller or journal bearings such as reduced frictional drag, no physical contact in the bearing, no need for lubricants, compatibility with high vacuum and ultra-clean environments, and ability to control shaft position within the bearing. The disadvantages of the AMB system are the increased cost and complexity, reduced bearing stiffness and the need for a controller. Still, there are certain applications, such as high speed machining, biomedical devices, and gyroscopes, where the additional cost of an AMB system can be justified. The inherent actuator capabilities of the AMB offer the potential for active balancing of spindles and micro-shaping capabilities for machine tools, The work presented in this paper concentrates on an AMB test program that utilizes the actuator capability to dynamically balance a spindle. In this study, an unbalanced AMB spindle system was enhanced with an LMS (Least Mean Squares) algorithm combined with an existing PID (proportional, integral, differential) control. This enhanced controller significantly improved the concentricity of an intentionally unbalanced shaft. The study included dynamic system analysis, test validation, control design and simulation, as well as experimental implementation using a digital LMS controller

Visual Management Vinotec V.1.0

OpenAIRE

Miquel Jorba, Toni

2007-01-01

El projecte amb nom clau Visual Management Vinotec neix de la necessitat d'administrar i gestionar el catàleg de productes d'una empresa que es dedica a la distribució de licors espirituosos (conyacs i whiskies), generesos (Jerez), vins i caves. Es tracta d'una eina web destinada als professionals del món dels destil·lats i del món vinícola. El proyecto con nombre clave Visual Management Vinotec nace de la necesitado de administrar y gestionar el catálogo de productos de una empresa que se...

Effects of long-term thyroid hormone level alterations, n-3 polyunsaturated fatty acid supplementation and statin administration in rats

Czech Academy of Sciences Publication Activity Database

Soukup, Tomáš

2014-01-01

Roč. 63, Suppl.1 (2014), S119-S131 ISSN 0862-8408 R&D Projects: GA ČR(CZ) GA304/08/0256; GA ČR(CZ) GA305/09/1228; GA ČR(CZ) GAP304/12/0259; GA MŠk(CZ) LH12058; GA MŠk(CZ) 7AMB12SK158; GA MŠk(CZ) 7AMB14SK123 Grant - others:EC(XE) LSH-CT-2004-511978 Institutional support: RVO:67985823 Keywords : thyroid hormones * n-3 polyunsaturated fatty acids (n-3 PUFA) * statin s * rat muscle proteins * cardiac remodeling Subject RIV: ED - Physiology Impact factor: 1.293, year: 2014

Numerical analysis of magnetically suspended rotor in HTR-10 helium circulator being dropped into auxiliary bearings

International Nuclear Information System (INIS)

Zhao Jingxiong; Yang Guojun; Li Yue; Yu Suyuan

2012-01-01

Active magnetic bearings (AMB) have been selected to support the rotor of primary helium circulator in commercial 10 Mega-Walt High Temperature Gas-cooled Reactor (HTR-10). In an AMB system, the auxiliary bearings are necessary to protect the AMB components in case of losing power. This paper performs the impact simulation of Magnetically Suspended Rotor in HTR-10 Helium Circulator being dropped into the auxiliary bearings using the finite element program ABAQUS. The dynamic response and the strain field of auxiliary bearings are analyzed. The results achieved by the numerical analysis are in agreement with the experiment results. Therefore, the feasibility of the design of auxiliary bearing and the possibility of using the AMB system in the HTR are proved. (authors)

Solubility of amphotericin B in water-lecithin-dispersions and lecithin-based submicron emulsions.

Science.gov (United States)

Salerno, Claudia; Perez, Sebastian; Monteagudo, Ezequiel; Carlucci, Adriana; Bregni, Carlos

2013-01-01

The aim of this work was to evaluate water-lecithin-dispersions (WLDs) as carriers for amphotericin B (AmB) and to compare the drug solubility in WLDs and O/W lecithin-based submicron emulsions (SMEs) in order to evaluate the influence of lecithin content on the dosage form solubilization of the active compound. WLDs and different SMEs with either 1.2 or 2.4% of lecithin were prepared. WLD with 2.4% lecithin show a 10-fold increase in solubilization of AmB compared with 1.2% lecithin WLD. SMEs with 1.2% lecithin show an increase of over 400 times in solubilization compared with WLD containing the same concentration of lecithin, whereas SMEs with 2.4% lecithin show an increase of over 40 times compared with the corresponding WLD. Drug solubilization in SMEs with 2.4% lecithin is not significantly greater than in those containing 1.2% lecithin. The content of surfactant Brij 97 ® had a significant influence on drug solubilization in SMEs (P < 0.05). Results indicate that indicate that SMEs are proper systems to solubilize AmB. It can be assumed that solubilization is due to the formulation microstructure and not to the separate components themselves.

Terbinafine inhibits Cryptococcus neoformans growth and modulates fungal morphology

Directory of Open Access Journals (Sweden)

Caroline Rezende Guerra

2012-08-01

Full Text Available Cryptococcus neoformans is an encapsulated fungus that causes cryptococcosis. Central nervous system infection is the most common clinical presentation followed by pulmonary, skin and eye manifestations. Cryptococcosis is primarily treated with amphotericin B (AMB, fluconazole (FLC and itraconazole (ITC. In the present work, we evaluated the in vitro effect of terbinafine (TRB, an antifungal not commonly used to treat cryptococcosis. We specifically examined the effects of TRB, either alone or in conjunction with AMB, FLC and ITC, on clinical C. neoformans isolates, including some isolates resistant to AMB and ITC. Broth microdilution assays showed that TRB was the most effective drug in vitro. Antifungal combinations demonstrated synergism of TRB with AMB, FLC and ITC. The drug concentrations used for the combination formulations were as much as 32 and 16-fold lower than the minimum inhibitory concentration (MIC values of FLC and AMB alone, respectively. In addition, calcofluor white staining revealed the presence of true septa in hyphae structures that were generated after drug treatment. Ultrastructural analyses demonstrated several alterations in response to drug treatment, such as cell wall alterations, plasma membrane detachment, presence of several cytoplasmic vacuoles and mitochondrial swelling. Therefore, we believe that the use of TRB alone or in combination with AMB and azoles should be explored as an alternative treatment for cryptococcosis patients who do not respond to standard therapies.

Roles of superconducting magnetic bearings and active magnetic bearings in attitude control and energy storage flywheel

International Nuclear Information System (INIS)

Tang Jiqiang; Fang Jiancheng; Ge, Shuzhi Sam

2012-01-01

Compared with conventional energy storage flywheel, the rotor of attitude control and energy storage flywheel (ACESF) used in space not only has high speed, but also is required to have precise and stable direction. For the presented superconducting magnetic bearing (SMB) and active magnetic bearing (AMB) suspended ACESF, the rotor model including gyroscopic couples is established originally by taking the properties of SMB and AMB into account, the forces of SMB and AMB are simplified by linearization within their own neighbors of equilibrium points. For the high-speed rigid discal rotor with large inertia, the negative effect of gyroscopic effect of rotor is prominent, the radial translation and tilting movement of rotor suspended by only SMB, SMB with equivalent PMB, or SMB together with PD controlled AMB are researched individually. These analysis results proved originally that SMB together with AMB can make the rotor be stable and make the radial amplitude of the vibration of rotor be small while the translation of rotor suspended by only SMB or SMB and PM is not stable and the amplitude of this vibration is large. For the stability of the high-speed rotor in superconducting ACESF, the AMB can suppress the nutation and precession of rotor effectively by cross-feedback control based on the separated PD type control or by other modern control methods.

Effects of formulation on the bioavailability of lutein and zeaxanthin: a randomized, double-blind, cross-over, comparative, single-dose study in healthy subjects.

Science.gov (United States)

Evans, Malkanthi; Beck, Mareike; Elliott, James; Etheve, Stephane; Roberts, Richard; Schalch, Wolfgang

2013-06-01

Lutein and zeaxanthin are macular pigments with a protective function in the retina. These xanthophylls must be obtained from the diet or added to foods or supplements via easy-to-use, stable formulations. The technique employed to produce these formulations may affect the bioavailability of the xanthophylls. Forty-eight healthy volunteers were randomized into this double-blind, cross-over study investigating the plasma kinetics of lutein provided as two different beadlet formulations. Subjects (n = 48) received a single dose of 20 mg of lutein as either a starch-matrix ("SMB", FloraGLO® Lutein 5 %) or as a cross-linked alginate-matrix beadlet ("AMB", Lyc-O-Lutein 20 %) formulation. Plasma concentrations of lutein and zeaxanthin were measured at 0, 1, 3, 6, 9, 12, 14, 24, 26, 28, 32, 36, 48, 72, 168, and 672 h. The mean plasma AUC(0-72h), AUC(0-672h), and C(max) for total lutein and zeaxanthin and their all-E-isomers were significantly increased (p < 0.001) from pre-dose concentrations in response to SMB and AMB. There was no difference in lutein T max between the two test articles. However, by 14 h post-dose, total plasma lutein increased by 7 % with AMB and by 126 % with SMB. Total lutein AUC(0-72h) and AUC(0-672h) were 1.8-fold and 1.3-fold higher, respectively, for SMB compared to AMB. Both formulations were well tolerated by subjects in this study. These findings confirm that the bioavailability of lutein and zeaxanthin critically depends on the formulation used and document a superiority of the starch-based over the alginate-based product in this study.

Effect of amalgam cuspal coverage on the fracture resistance of endodontically treated teeth

Directory of Open Access Journals (Sweden)

Mahshid Mohammdi Basir

2013-05-01

Full Text Available   Background and Aims: Endodontically treated teeth are prone to fracture because they loose a big amount of their structure. The treatment plan of those teeth is completed when they are rehabilitated with a strong and functional restoration. The purpose of this study was to evaluate the fracture resistance of endodontically treated teeth restored with amalgam cuspal coverage in comparison with other restorative techniques.   Materials and Methods: 40 human healthy maxillary premolars were divided into 4 groups: group1 (S: sound teeth, group 2(Co: endodontically treated teeth with MOD cavity restored with bonding and composite, group 3(Am-B: endodontically treated teeth with MOD cavity restored with bonding and amalgam and group 4 (Am-CC: endodontically treated teeth with MOD cavity restored with amalgam cuspal coverage. Then the restorations were stored in water and room temperature for 100 days at then thermocycled for 500 cycles between water baths at (5.5 ± 1 and (55 ± 1 0 C. The fracture resistance was evaluated by universal testing machine (Instron, 1195 UK with the compressive force of about 2000 N in 0.5 mm/min. The fracture modes were evaluated in four groups by a stereomicroscope. Statistical analysis (Scheffe test was done for all groups (P0.05. The lowest fracture resistance was found in group 2 (Co (384 ± 137.4 N that had no significant difference with group 3 (Am-B (P>0.05. The fracture resistance in group 4 was significantly higher than group 2 (Co and 3 (Am-B. The fracture mode in group 1 was cohesive within tooth and in group 2 (Co and 3 (Am-B was mixed cohesive and adhesive, and in group 4 was cohesive within in restorative material.   Conclusion: The highest fracture resistance was found in teeth that received amalgam cuspal coverage.

Neonatal colonization of germ-free mice with Bifidobacterium longum prevents allergic sensitization to major birch pollen allergen Bet v 1

Czech Academy of Sciences Publication Activity Database

Schwarzer, Martin; Šrůtková, Dagmar; Schabussova, I.; Hudcovic, Tomáš; Akgün, J.; Wiedermann, U.; Kozáková, Hana

2013-01-01

Roč. 31, č. 46 (2013), s. 5405-5412 ISSN 0264-410X R&D Projects: GA ČR GA303/09/0449; GA MŠk 7AMB12AT020 Institutional support: RVO:61388971 Keywords : Allergy * Bifidobacterium * Germ-free mice Subject RIV: EC - Immunology Impact factor: 3.485, year: 2013

Sistema predictiu per a evolució de pacients. Aplicació al cas d'asma infantil

OpenAIRE

Rubia Galera, Ivan de La

2015-01-01

[CATALÀ] S'ha dissenyat una aplicació que permet treballar amb dades de pacients i episodis, preprocessar-les i entrenar models amb algorismes d'aprenentatge automàtic que ofereixen bons resultats. S'ha experimentat amb dades de pacients d'asma infantil de l'hospital de Sant Joan de Déu. [ANGLÈS] We've developed an application that can deal with patient data, preprocess it and train models with machine learning algorithms that have given good results. We've experimented with data from Hosp...

Blockchain per l'educació

OpenAIRE

Arcas Sanz, Joan Manel

2017-01-01

La tecnologia Blockchain o de cadena de blocs va sorgir com a suport de la xarxa de monedes virtuals Bitcoin, però amb la recent aparició dels Smart Contracts existeix la possibilitat de crear infinitud d'aplicacions que funcionin de manera distribuïda i sense la necessitat d'entitats intermediàries. En aquest article es presenta una introducció a la tecnologia Blockchain, des dels seus inicis amb Bitcoin fins a l'actualitat amb la utilització dels Smart Contracts. Posteriorment es comparen a...

Response of CR-39 Detector Against Fast Neutron Using D-Polyethylene and H-Polyethylene Radiator

International Nuclear Information System (INIS)

Sofyan, Hasnel

1996-01-01

The research on the response of detector CR-39 by using D-Polyethylene and H-Polyethylene radiator has been carried out. The optimum number of nuclear tracks was found with the use of 30 % NaOH at 80 + 0,5oC for 80 minutes of etching time. The comparison of CR-39 detector response caused by D-Polyethylene radiator against H-Polyethylene radiator of irradiation in air, were found to be 1.18 and 0.84 for 241Am-Be neutron source and neutron source from reactor respectively. For phantom irradiation, the results were found to be 1.75 for 241Am-Be neutron source, and 0.77 for neutron source from reactor

Registre d'entrades i eixides per a l'administració pública

OpenAIRE

Oliver Company, Alfredo

2005-01-01

Aquesta memòria representa la definició del meu projecte final de carrera amb una aplicació destinada al registre d'entrades i eixides de l'Administració pública. He emprat eines de plataformes lliures i obertes per al desenvolupament del projecte, amb tecnologia J2EE. A més, hi ha l'objectiu de fer servir i provar arquitectures d'última generació com Enterprise JavaBeans Preview_2 (EJB) 3.0 (5/11/04) per a la lògica de negoci, Hibernate 3.0 alpha (actualment hi ha la beta 1.0 publicada el 20...

ART PÚBLIC. REPTES I OPORTUNITATS (II. LA CONSOLIDACIÓ DELS LLENGUATGES

Directory of Open Access Journals (Sweden)

Antoni Remesar

2016-01-01

El lector pot seguir el text o aturar-se en els quadres. Combinar el text amb els quadres. Usar les possibilitats de realitat augmentada. El treball conclou amb un estudi de cas dedicat a Josep M Subirachs.

«Cual doctora en cielo graduada... ». La poesia femenina per als certàmens literaris amb motiu de la beatificació i canonització de Teresa de Jesús (València, 1614 i 1621; Barcelona, 1614

Directory of Open Access Journals (Sweden)

Verònica Zaragoza Gómez

2015-12-01

Full Text Available L’objectiu d’aquest estudi és examinar les composicions poètiques aportades per dones als tres certàmens celebrats a València i Barcelona, amb motiu de la beatificació (1614 i posterior canonització (1622 de Teresa de Jesús; dos moments clau per a la consolidació de la fama de la carmelitana avilesa que van possibilitar l’exhibició pública i impressió de poesia femenina. Analitzem també la participació femenina catalana al certamen celebrat a Saragossa el 1614 per la beatificació. L’estudi està enfocat des d’una perspectiva femenina, a través de la revisió de dihuit poesies amb signatura de dones que ens han transmès les extenses relacions impreses. Al llarg del comentari dels poemes, analitzem la percepció general que aquestes dones tenen de Teresa de Jesús y ens centrem en algunes de les imatges tòpiques sobre la vida i l’obra de la fundadora. Incidim en la documentació biogràfica de les autores, setze poetes ‘de circumstàncies’ conegudes tan sols per un nom i cognom(s estampats a la rúbrica. A més, proporcionem unes breus pinzellades sobre la recepció femenina de la figura de la carmelita avilesa a l’àmbit lingüístic català. The aim of this study is to examine the poetic compositions made by women in the three contests held in Valencia and Barcelona on the occasion of the beatification (1614 and subsequent canonization (1622 of Teresa of Jesus; two special moments for the consoli-dation of the fame of the Carmelite nun which allowed the public display and then its printing of feminine poetry. We also analyze the Catalan female participation in the con-test held in Zaragoza in 1614 for the beatification. The study is focused from a female perspective, through the review of eighteen poems signed by women which arrived to us through extensive printed relations. Throughout the commentary of the poems, we analyze the general perception that these women have about Teresa of Jesus and we focus on some

Common ragweed (Ambrosia artemisiifolia L.): allergenicity and molecular characterization of pollen after plant exposure to elevated NO2.

Science.gov (United States)

Zhao, Feng; Elkelish, Amr; Durner, Jörg; Lindermayr, Christian; Winkler, J Barbro; Ruёff, Franziska; Behrendt, Heidrun; Traidl-Hoffmann, Claudia; Holzinger, Andreas; Kofler, Werner; Braun, Paula; von Toerne, Christine; Hauck, Stefanie M; Ernst, Dieter; Frank, Ulrike

2016-01-01

Ragweed pollen is the main cause of allergenic diseases in Northern America, and the weed has become a spreading neophyte in Europe. Climate change and air pollution are speculated to affect the allergenic potential of pollen. The objective of this study was to investigate the effects of NO2 , a major air pollutant, under controlled conditions, on the allergenicity of ragweed pollen. Ragweed was exposed to different levels of NO2 throughout the entire growing season, and its pollen further analysed. Spectroscopic analysis showed increased outer cell wall polymers and decreased amounts of pectin. Proteome studies using two-dimensional difference gel electrophoresis and liquid chromatography-tandem mass spectrometry indicated increased amounts of several Amb a 1 isoforms and of another allergen with great homology to enolase Hev b 9 from rubber tree. Analysis of protein S-nitrosylation identified nitrosylated proteins in pollen from both conditions, including Amb a 1 isoforms. However, elevated NO2 significantly enhanced the overall nitrosylation. Finally, we demonstrated increased overall pollen allergenicity by immunoblotting using ragweed antisera, showing a significantly higher allergenicity for Amb a 1. The data highlight a direct influence of elevated NO2 on the increased allergenicity of ragweed pollen and a direct correlation with an increased risk for human health. © 2015 John Wiley & Sons Ltd.

Ammonium Bicarbonate Transport in Anion Exchange Membranes for Salinity Gradient Energy

KAUST Repository

Geise, Geoffrey M.

2013-09-17

Many salinity gradient energy technologies such as reverse electrodialysis (RED) rely on highly selective anion transport through polymeric anion exchange membranes. While there is considerable interest in using thermolytic solutions such as ammonium bicarbonate (AmB) in RED processes for closed-loop conversion of heat energy to electricity, little is known about membrane performance in this electrolyte. The resistances of two commercially available cation exchange membranes in AmB were lower than their resistances in NaCl. However, the resistances of commercially available anion exchange membranes (AEMs) were much larger in AmB than in NaCl, which would adversely affect energy recovery. The properties of a series of quaternary ammonium-functionalized poly(phenylene oxide) and Radel-based AEMs were therefore examined to understand the reasons for increased resistance in AmB to overcome this performance penalty due to the lower mobility of bicarbonate, 4.59 × 10-4 cm2/(V s), compared to chloride, 7.90 × 10-4 cm2/(V s) (the dilute aqueous solution mobility ratio of HCO3 - to Cl- is 0.58). Most membrane resistances were generally consistent with the dilute solution mobilities of the anions. For a few key samples, however, increased water uptake in AmB solution reduced the ionic resistance of the polymer compared to its resistance in NaCl solution. This increased water uptake was attributed to the greater hydration of the bicarbonate ion compared to the chloride ion. The increased resistance due to the use of bicarbonate as opposed to chloride ions in AEMs can therefore be mitigated by designing polymers that swell more in AmB compared to NaCl solutions, enabling more efficient energy recovery using AmB thermolytic solutions in RED. © 2013 American Chemical Society.

Ammonium Bicarbonate Transport in Anion Exchange Membranes for Salinity Gradient Energy

KAUST Repository

Geise, Geoffrey M.; Hickner, Michael A.; Logan, Bruce E.

2013-01-01

Many salinity gradient energy technologies such as reverse electrodialysis (RED) rely on highly selective anion transport through polymeric anion exchange membranes. While there is considerable interest in using thermolytic solutions such as ammonium bicarbonate (AmB) in RED processes for closed-loop conversion of heat energy to electricity, little is known about membrane performance in this electrolyte. The resistances of two commercially available cation exchange membranes in AmB were lower than their resistances in NaCl. However, the resistances of commercially available anion exchange membranes (AEMs) were much larger in AmB than in NaCl, which would adversely affect energy recovery. The properties of a series of quaternary ammonium-functionalized poly(phenylene oxide) and Radel-based AEMs were therefore examined to understand the reasons for increased resistance in AmB to overcome this performance penalty due to the lower mobility of bicarbonate, 4.59 × 10-4 cm2/(V s), compared to chloride, 7.90 × 10-4 cm2/(V s) (the dilute aqueous solution mobility ratio of HCO3 - to Cl- is 0.58). Most membrane resistances were generally consistent with the dilute solution mobilities of the anions. For a few key samples, however, increased water uptake in AmB solution reduced the ionic resistance of the polymer compared to its resistance in NaCl solution. This increased water uptake was attributed to the greater hydration of the bicarbonate ion compared to the chloride ion. The increased resistance due to the use of bicarbonate as opposed to chloride ions in AEMs can therefore be mitigated by designing polymers that swell more in AmB compared to NaCl solutions, enabling more efficient energy recovery using AmB thermolytic solutions in RED. © 2013 American Chemical Society.

Inductive displacement sensors with a notch filter for an active magnetic bearing system.

Science.gov (United States)

Chen, Seng-Chi; Le, Dinh-Kha; Nguyen, Van-Sum

2014-07-15

Active magnetic bearing (AMB) systems support rotating shafts without any physical contact, using electromagnetic forces. Each radial AMB uses two pairs of electromagnets at opposite sides of the rotor. This allows the rotor to float in the air gap, and the machine to operate without frictional losses. In active magnetic suspension, displacement sensors are necessary to detect the radial and axial movement of the suspended object. In a high-speed rotating machine equipped with an AMB, the rotor bending modes may be limited to the operating range. The natural frequencies of the rotor can cause instability. Thus, notch filters are a useful circuit for stabilizing the system. In addition, commercial displacement sensors are sometimes not suitable for AMB design, and cannot filter the noise caused by the natural frequencies of rotor. Hence, implementing displacement sensors based on the AMB structure is necessary to eliminate noises caused by natural frequency disturbances. The displacement sensor must be highly sensitive in the desired working range, and also exhibit a low interference noise, high stability, and low cost. In this study, we used the differential inductive sensor head and lock-in amplifier for synchronous demodulation. In addition, an active low-pass filter and a notch filter were used to eliminate disturbances, which caused by natural frequencies. As a consequence, the inductive displacement sensor achieved satisfactory linearity, high sensitivity, and disturbance elimination. This sensor can be easily produced for AMB applications. A prototype of these displacement sensors was built and tested.

Classificació de proves no paramètriques. Com aplicar-les en SPSS

Directory of Open Access Journals (Sweden)

Vanesa Berlanga-Silvente

2012-07-01

Full Text Available Les proves no paramètriques engloben una sèrie de proves estadístiques, que tenen com a denominador comú l'absència de assumpcions sobre la llei de probabilitat que segueix la població de la qual ha estat extreta la mostra. Per aquesta raó és comú referir-s'hi com a proves de distribució lliure. A l'article es descriuen i treballen les proves no paramètriques ressaltant el seu fonament i les indicacions per al seu ús quan es tracta d'una sola mostra (Chi-quadrat, de dues mostres amb dades independents (U de Mann-Whitney, de dues mostres amb dades relacionades (T de Wilcoxon, de diverses mostres amb dades independents (H de Kruskal-Wallis i de diverses mostres amb dades relacionades (Friedman.

Control Design of Active Magnetic Bearings for Rotors Subjected to Destabilising Seal Forces - Theory & Experiment

DEFF Research Database (Denmark)

Lauridsen, Jonas Skjødt

. At present, there is no generally accepted method for determination of dynamic seal forces. Therefore, large uncertainties must be expected when modelling dynamic seal forces and consequently also in rotor-dynamic stability analysis. This thesis focuses on i) closed loop identification of uncertain AMB...... parameters, ii) closed loop identification of unknown stiffness and damping coefficients of a dynamicseal model and iii) the design of AMB controllers to handle dynamic seal forces. Controllers that can guarantee stability and performance in the presence of uncertainseal forces are of special interest...... the uncertaintiesin seal forces and for LPV control synthesis, to compensate for known changes in seal forces due to changes in operating conditions. A rotor dynamic test facility with a rigid rotor, two radial AMBs and one annular test seal is used for i) closed loop identification of parameters in the AMB...

Design of Active Magnetic Bearing Controllers for Rotors Subjected to Gas Seal Forces

DEFF Research Database (Denmark)

Lauridsen, Jonas Skjødt; Santos, Ilmar F.

2018-01-01

Proper design of feedback controllers is crucial for ensuring high performance of Active Magnetic Bearing (AMB) supported rotor dynamic systems. Annular seals in those systems can contribute with significant forces, which, in many cases, are hard to model in advance due to complex geometries...... of the seal and multiphase fluids. Hence, it can be challenging to design AMB controllers that will guarantee robust performance for these kinds of systems. This paper demonstrates the design, simulation and experimental results of model based controllers for AMB systems, subjected to dynamic seal forces....... The controllers are found using H-infinity - and µ synthesis and are based on a global rotor dynamic model in-which the seal coefficients are identified in-situ. The controllers are implemented in a rotor-dynamic test facility with two radial AMBs and one annular seal with an adjustable inlet pressure. The seal...

A Ca(v)3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane

Czech Academy of Sciences Publication Activity Database

Rzhepetskyy, Yuriy; Lazniewska, Joanna; Proft, Juliane; Campiglio, M.; Flucher, B. E.; Weiss, Norbert

2016-01-01

Roč. 10, č. 5 (2016), s. 346-354 ISSN 1933-6950 R&D Projects: GA ČR GA15-13556S; GA MŠk 7AMB15FR015 Institutional support: RVO:61388963 Keywords : Ca(v)3 * 2 channel * Stac adaptor protein * trafficking * T-type calcium channel Subject RIV: CE - Biochemistry Impact factor: 2.042, year: 2016

Comunidad Hispana de Everquest 2

OpenAIRE

Ybáñez Domínguez, Ainhoa

2011-01-01

Comunidad Hispana de Everquest 2 programada en PHP, incluye administración propia de secciones, integración con login de foro vBulletin 4, integración con login de galería multimedia Coppermine, e integración con login de wiki Mediawiki de forma parcial. Comunitat Hispana d'Everquest 2 programada en PHP, inclou administració pròpia de seccions, integració amb identificació a fòrum vBulletin 4, integració amb identificació a galeria multimèdia Coppermine, i integració amb identificació a wi...

Disseny d’una sèrie de motors de baixa velocitat i parell elevat

OpenAIRE

Arranz Bernal, Guillermo

2016-01-01

El present projecte té com a principal objectiu el disseny d’una sèrie formada per nou motors de baixa velocitat i elevat parell, coneguts com Direct Drive o Motors Torque. Aquests motors seran d’una tipologia de màquina síncrona amb imants permanents interiors/exteriors de Neodimi amb un bobinat concentrat. El punt de partida són les especificacions de parell i velocitat juntament amb les limitacions econòmiques específiques per aquesta sèrie sencera. A més, aquesta tind...

Estudio comparativo de RM perfusión en pacientes diagnosticados de hidrocefalia normotensiva con pacientes controles.

OpenAIRE

Carrascosa Bisquert, Blanca

2012-01-01

Diversos estudis han demostrat que existeix una disminució en la irrigació de la substància blanca periventricular en pacients diagnosticats d'hidrocefàlia normotensiva quan es comparen amb subjectes normals. Amb l'objectiu de demostrar aquestes troballes, pacients afectes d'aquesta patología es van sotmetre a una RM cerebral morfológica, un estudi de dinàmica de fluxe de LCR i un estudi de perfusió. Amb aquestes exploracions es va demostrar un augment en l'índex d'Evans i una disminución del...

Ensenyar i aprendre coneixements gramaticals al voltant de la frase : una experiència a cicle inicial

OpenAIRE

Méndez i Navarro, Anna

2012-01-01

Amb l’objectiu de donar suport als centres en el tractament de les llengües en el context de l’actual diversitat lingüística i cultural, el Departament d’Ensenyament promou des del curs 2007-2008 el nou Projecte d’actualització de la metodologia d’Immersió Lingüística. El projecte consisteix bàsicament en facilitar a les escoles integrants els recursos formatius necessaris per assolir amb èxit aquest repte. Una de les activitats de les diverses accions formatives es complementa amb unes sessi...

Elastic behavior of MFI-type zeolites: Compressibility of H-ZSM-5 in penetrating and non-penetrating media

International Nuclear Information System (INIS)

Quartieri, Simona; Montagna, Gabriele; Arletti, Rossella; Vezzalini, Giovanna

2011-01-01

The elastic behavior of H-ZSM-5 was investigated by in-situ synchrotron X-ray powder diffraction, using both silicone oil (s.o.) and (16:3:1) methanol:ethanol:water (m.e.w.) as 'non-penetrating' and 'penetrating' pressure transmitting media, respectively. From P amb to 6.2 GPa the volume reduction observed in s.o. is 16.6%. This testifies that H-ZSM-5 is one of the most flexible microporous materials up to now compressed in s.o. Volume reduction observed in m.e.w. up to 7.6 GPa is 14.6%. A strong increase in the total electron number of the extraframework system, due to the penetration of water/alcohol molecules in the pores, is observed in m.e.w. This effect is the largest up to now observed in zeolites undergoing this phenomenon without cell volume expansion. The higher compressibility in s.o. than in m.e.w. can be ascribed to the penetration of the extra-water/alcohol molecules, which stiffen the structure and contrast the channel deformations. - Graphical abstract: High-pressure behavior of H-ZSM-5 compressed in (16:3:1) methanol:ethanol:water: (a) projection of the structure along the [0 1 0] direction at P amb , 2 GPa and after pressure release to original ambient conditions (P amb (rev)), and (b) P-dependence of the extraframework content expressed as total number of electrons (gray square represents the number of the extraframework electrons at P amb after decompression). Highlights: → X-ray powder diffraction study of H-ZSM-5 compressibility. → H-ZSM-5 is one of the softest porous material compressed in silicon oil. → Penetration of additional water/alcohol molecules upon compression in m.e.w. → Extra molecules contribute to stiffen the structure and to contrast HP effects.

Inductive Displacement Sensors with a Notch Filter for an Active Magnetic Bearing System

Directory of Open Access Journals (Sweden)

Seng-Chi Chen

2014-07-01

Full Text Available Active magnetic bearing (AMB systems support rotating shafts without any physical contact, using electromagnetic forces. Each radial AMB uses two pairs of electromagnets at opposite sides of the rotor. This allows the rotor to float in the air gap, and the machine to operate without frictional losses. In active magnetic suspension, displacement sensors are necessary to detect the radial and axial movement of the suspended object. In a high-speed rotating machine equipped with an AMB, the rotor bending modes may be limited to the operating range. The natural frequencies of the rotor can cause instability. Thus, notch filters are a useful circuit for stabilizing the system. In addition, commercial displacement sensors are sometimes not suitable for AMB design, and cannot filter the noise caused by the natural frequencies of rotor. Hence, implementing displacement sensors based on the AMB structure is necessary to eliminate noises caused by natural frequency disturbances. The displacement sensor must be highly sensitive in the desired working range, and also exhibit a low interference noise, high stability, and low cost. In this study, we used the differential inductive sensor head and lock-in amplifier for synchronous demodulation. In addition, an active low-pass filter and a notch filter were used to eliminate disturbances, which caused by natural frequencies. As a consequence, the inductive displacement sensor achieved satisfactory linearity, high sensitivity, and disturbance elimination. This sensor can be easily produced for AMB applications. A prototype of these displacement sensors was built and tested.

Heat acclimation responses of an ultra-endurance running group preparing for hot desert-based competition.

Science.gov (United States)

Costa, Ricardo J S; Crockford, Michael J; Moore, Jonathan P; Walsh, Neil P

2014-01-01

Heat acclimation induces adaptations that improve exercise tolerance in hot conditions. Here we report novel findings into the effects of ultra-marathon specific exercise load in increasing hot ambient conditions on indices of heat acclimation. Six male ultra-endurance runners completed a standard pre-acclimation protocol at 20°C ambient temperature (T amb), followed by a heat acclimation protocol consisting of six 2 h running exercise-heat exposures (EH) at 60% VO2max on a motorised treadmill in an environmental chamber. Three EH were performed at 30°C T amb, followed by another three EH at 35°C T amb. EH were separated by 48 h within T amb and 72 h between T amb. Nude body mass (NBM), blood and urine samples were collected pre-exercise; while NBM and urine were collected post-exercise. Rectal temperature (T re), heart rate (HR), thermal comfort rating (TCR) and rating of perceived exertion were measured pre-exercise and monitored every 5 min during exercise. Water was provided ad libitum during exercise. Data were analysed using a repeated measures and one-way analysis of variance (ANOVA), with post hoc Tukey's HSD. Significance was accepted as Pheat acclimation in all ultra-endurance runners. Further, heat acclimation responses occurred with increasing EH to 35°C T amb. Preventing exertional heat illnesses and optimising performance outcomes in ultra-endurance runners may occur with exposure to at least 2 h of exercise-heat stress on at least two occasions in the days leading up to multi-stage ultra-marathon competition in the heat.

Effects of Dissolved Oxygen Concentration and Iron Addition on Immediate-early Gene Expression of Magnetospirillum gryphiswaldense MSR-1

DEFF Research Database (Denmark)

Zhuang, Shiwen; Anyaogu, Diana Chinyere; Kasama, Takeshi

2017-01-01

in cultures at 0.5% O2 compared to those at higher oxygen tensions. Moreover, expression of katG (catalase-peroxidase gene) and feoB2 (ferrous transport protein B2 gene) was reduced markedly by iron addition, regardless of oxygen conditions. The data provides a greater understanding of molecular response...

46 CFR Table 151.05 to Subpart 151... - Summary of Minimum Requirements

Science.gov (United States)

2010-10-01

... Vent F Yes .55-1(e) NA NA G Potassium hydroxide solution, see Caustic potash solution iso-Propanolamine... chlorate solution (50% or less) Atmos. Amb. III 1 i 2 i Integral Gravity Open Open II G-1 NR Vent N No .50...

Què ha de tenir en compte l'usuari d'ordinador?

OpenAIRE

Valls Oriol, Maria Mercè

2014-01-01

El treball que aquí es presenta és la creació d'un curs online pilot amb la plataforma online i gratuïta Chamilo per realitzar formació en l'empresa Consorci Sanitari (que no té plataforma virtual d'aprenentatge implantada). La temàtica del curs es basa en tot el que fa referència a l'ergonomia relacionada amb la utilització dels ordinadors. La creació del curs s'ha realitzat amb la metodologia ADDIE obtenint resultats positius, fet que conclou que la implementació d'una plataforma virtual d'...

Inmunodeficiencias primarias en el adulto : estudio de los déficits de subclases de la IgG /

OpenAIRE

Gracia Roldán, Javier de

2009-01-01

Consultable des del TDX Títol obtingut de la portada digitalitzada El dèficit d'IgG2 han estat estudiats a la població infantil i demostrada la seva relació de causalitat amb patologia pulmonar; tanmateix, existeixen pocs estudis, amb resultats contradictoris, amb relació a la població adulta. Respecte del dèficit selectiu d'IgG3 i IgG4 com a causa de patologia, no existeix unanimitat de criteris degut a la baixa sensibilitat i especificitat de les de tècniques de quantificació de les s...

Petardos, coetes y mucha química

OpenAIRE

Prada Pérez de Azpeitia, Fernando Ignacio de

2014-01-01

Els espectaculars efectes que produeixen els petards i coets estan relacionats amb la ciència, per la qual cosa poden ser aprofitats com un inusual i atractiu recurs didàctic per a la química. Amb això es pretén aconseguir augmentar l'interès dels estudiants cap a la ciència, alhora que ampliar el coneixement sobre les reaccions químiques relacionades amb la vida quotidiana. Les experiències proposades han estat realitzades per estudiants davant un públic molt variat en fires de ciència di...

Les cavitats de la Serra de na Burguesa. Zona 9: Son Boronat-L'Hostalet (2a part) (Calvià, Mallorca)

OpenAIRE

Ginard, Antelm; Bover, Pere; Vicens, Damià; Crespí, Damià; Vadell, Mateu; Barceló, Miquel Àngel

2009-01-01

Es presenta la descripció i topografia de 7 cavitats naturals i 1 mina del SO de la serra de na Burguesa (serra de Tramuntana, Mallorca), entre les quals destaquen la cova-avenc de na Picacento per presentar un conducte de dissolució, la cova des Coral·loides amb 324 m de recorregut i 27 m de desnivell i l’avenc de s’Eriçó amb un desnivell de 36 m. També s’ha topografiat una mina destinada a l’extracció de guix. A la cova des Coral·loides es va trobar l’esquelet d’un individu de Myotragus bal...

Proteomic and Transcriptomic Analysis of Aspergillus fumigatus on Exposure to Amphotericin B▿ †

Science.gov (United States)

Gautam, Poonam; Shankar, Jata; Madan, Taruna; Sirdeshmukh, Ravi; Sundaram, Curam Sreenivasacharlu; Gade, Wasudev Namdeo; Basir, Seemi Farhat; Sarma, Puranam Usha

2008-01-01

Amphotericin B (AMB) is the most widely used polyene antifungal drug for the treatment of systemic fungal infections, including invasive aspergillosis. It has been our aim to understand the molecular targets of AMB in Aspergillus fumigatus by genomic and proteomic approaches. In transcriptomic analysis, a total of 295 genes were found to be differentially expressed (165 upregulated and 130 downregulated), including many involving the ergosterol pathway, cell stress proteins, cell wall proteins, transport proteins, and hypothetical proteins. Proteomic profiles of A. fumigatus alone or A. fumigatus treated with AMB showed differential expression levels for 85 proteins (76 upregulated and 9 downregulated). Forty-eight of them were identified with high confidence and belonged to the above-mentioned categories. Differential expression levels for Rho-GDP dissociation inhibitor (Rho-GDI), secretory-pathway GDI, clathrin, Sec 31 (a subunit of the exocyst complex), and RAB GTPase Ypt51 in response to an antifungal drug are reported here for the first time and may represent a specific response of A. fumigatus to AMB. The expression of some of these genes was validated by real-time reverse transcription-PCR. The AMB responsive genes/proteins observed to be differentially expressed in A. fumigatus may be further explored for novel drug development. PMID:18838595

Proteomic and transcriptomic analysis of Aspergillus fumigatus on exposure to amphotericin B.

Science.gov (United States)

Gautam, Poonam; Shankar, Jata; Madan, Taruna; Sirdeshmukh, Ravi; Sundaram, Curam Sreenivasacharlu; Gade, Wasudev Namdeo; Basir, Seemi Farhat; Sarma, Puranam Usha

2008-12-01

Amphotericin B (AMB) is the most widely used polyene antifungal drug for the treatment of systemic fungal infections, including invasive aspergillosis. It has been our aim to understand the molecular targets of AMB in Aspergillus fumigatus by genomic and proteomic approaches. In transcriptomic analysis, a total of 295 genes were found to be differentially expressed (165 upregulated and 130 downregulated), including many involving the ergosterol pathway, cell stress proteins, cell wall proteins, transport proteins, and hypothetical proteins. Proteomic profiles of A. fumigatus alone or A. fumigatus treated with AMB showed differential expression levels for 85 proteins (76 upregulated and 9 downregulated). Forty-eight of them were identified with high confidence and belonged to the above-mentioned categories. Differential expression levels for Rho-GDP dissociation inhibitor (Rho-GDI), secretory-pathway GDI, clathrin, Sec 31 (a subunit of the exocyst complex), and RAB GTPase Ypt51 in response to an antifungal drug are reported here for the first time and may represent a specific response of A. fumigatus to AMB. The expression of some of these genes was validated by real-time reverse transcription-PCR. The AMB responsive genes/proteins observed to be differentially expressed in A. fumigatus may be further explored for novel drug development.

SPiDer: Smart Pill Dispenser

OpenAIRE

Moreno Vázquez, Jonatan

2013-01-01

Aquest projecte proposa el sistema SPiDer el qual te l'objectiu d'assistir a la gent gran en el procés de medicar-se evitant els problemes associats amb la baixa adherència existent actualment amb els calendaris farmacològics receptats pels doctors.

Active Magnetic Bearings Stiffness and Damping Identification from Frequency Characteristics of Control System

Directory of Open Access Journals (Sweden)

Chaowu Jin

2016-01-01

Full Text Available At present, the stiffness and damping identification for active magnetic bearings (AMBs are still in the stage of theoretical analysis. The theoretical analysis indicates that if the mechanical structure and system parameters are determined, AMBs stiffness and damping are only related to frequency characteristic of control system, ignoring operating condition. More importantly, few verification methods are proposed. Considering the shortcomings of the theoretical identification, this paper obtains these coefficients from the experiment by using the magnetic bearing as a sine exciter. The identification results show that AMBs stiffness and damping have a great relationship with the control system and rotating speed. Specifically, at low rotating speed, the stiffness and damping can be obtained from the rotor static suspension by adding the same excitation frequency. However, at high speed, different from the static suspension situation, the AMBs supporting coefficients are not only related to the frequency characteristics of control system, but also related to the system operating conditions.

Ambazone-lipoic acid salt: Structural and thermal characterization

Energy Technology Data Exchange (ETDEWEB)

Kacso, Irina [National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath street, 400293 Cluj-Napoca (Romania); Racz, Csaba-Pal; Santa, Szabolcs [Babes-Bolyai' University, Faculty of Chemistry, 11 Arany Janos street, Cluj-Napoca (Romania); Rus, Lucia [' Iuliu Hatieganu' University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Louis Pasteur street, 400349 Cluj-Napoca (Romania); Dadarlat, Dorin; Borodi, Gheorghe [National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath street, 400293 Cluj-Napoca (Romania); Bratu, Ioan, E-mail: ibratu@gmail.com [National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath street, 400293 Cluj-Napoca (Romania)

2012-12-20

Highlights: Black-Right-Pointing-Pointer Salt of Ambazone with lipoic acid obtained by solvent-drop grinding. Black-Right-Pointing-Pointer Ambazone lipoate salt crystallizes in monoclinic system. Black-Right-Pointing-Pointer FTIR data suggest the deprotonation of the lipoic acid. Black-Right-Pointing-Pointer Thermal behaviour different of ambazone salt as compared to the starting compounds. - Abstract: A suitable method for increasing the solubility, dissolution rate and consequently the bioavailability of poor soluble acidic or basic drugs is their salt formation. The aim of this study is to investigate the structural and thermal properties of the compound obtained by solvent drop grinding (SDG) method at room temperature, starting from the 1:1 molar ratios of ambazone (AMB) and {alpha}-lipoic acid (LA). The structural characterization was performed with X-ray powder diffraction (XRPD) and infrared spectroscopy (FTIR). The thermal behaviour of the obtained compound (AMB{center_dot}LA) was investigated by differential scanning calorimetry (DSC) and thermogravimetry (TG). The photopyroelectric calorimetry, in front detection configuration (FPPE), was applied to measure and compare the room temperature values of one dynamic thermal parameter (thermal effusivity) for starting and resulting compounds. Both structural and supporting calorimetric techniques pointed out a salt structure for AMB{center_dot}LA compound as compared to those of the starting materials.

Dímero-D y resultados clínicos a corto plazo en el embolismo pulmonar: papel del tamaño del coágulo en la arteria pulmonar

OpenAIRE

García Gómez, Raquel

2013-01-01

Introducció: Existeixen factors pronòstics en el embolisme pulmonar (EP) que influeixen en la gravetat del mateix i és necessari estudiar-los. -Objectiu: comparar nivells de dímer-D amb la grandària del coàgul en l'artèria pulmonar en pacients amb EP. -Material i mètodes: Cohorts retrospectiu en pacients amb EP simptomàtic entre 2008-2010 en un hospital comarcal. -Resultats: Els nivells de dímer-D van ser de 4068±2764 ng/ml. En el 46,9% el coàgul es va situar centralment, en el 31,3% va ser s...

Pla d'intervenció individual en la dislèxia i suport a les famílies en el trastorn per dèficit d'atenció i hiperactivitat

OpenAIRE

Jubert Anfrons, Maria Victoria

2013-01-01

Aquest projecte té com a objectiu principal la intervenció en un context d'educació formal, obtenir experiència professional i definir quin és realment el paper del psicopedagog. Consta de tres activitats: un taller per a pares i mares de nens amb TDAH, un pla reeducatiu per a una alumna amb dislèxia i un taller de competència social per a nens amb TEA. El procés d'investigació-acció ha regit tot el procés, el qual es basa en els principis bàsics de la LEC (12/2009) de qualitat i equitat educ...

L'alè del mar: Intercanvis oceà-atmosfera i canvi global

OpenAIRE

Simó, Rafel

2004-01-01

La biosfera contribueix fortament a regular la composició de l'atmosfera de la Terra i, amb la composició, en regula també les propietats de reactivitat química, de reflexió de la radiació i d'acumulació de calor. És a dir, que la vida no solament s'adapta a l'entorn fisicoquímic (que està determinat per les condicions geològiques i climàtiques) sinó que a la vegada el modifica. Aquesta relació bidireccional de la vida amb l'entorn (també amb el clima) fa que el sistema Terra tingui un funcio...

Efectivitat de la teràpia craneosacral en el dolor lumbar crònic no específic: estudi experimental i aleatoritzat.

OpenAIRE

Grañó Martí, Sílvia

2015-01-01

Pregunta clínica: És més efectiu el tractament convencional del dolor crònic lumbar no específic en l'edat adulta si li afegim el tractament amb teràpia craneosacral? Objectiu: Valorar l'efectivitat de la teràpia craneosacral en persones en edat adulta amb dolor crònic lumbar no específic. Metodologia: Es realitzarà un estudi experimental a partir d'un assaig clínic aleatoritzat i amb un simple cec. Es durà a terme durant l'any 2016 i mitjans de 2017 a la població de Lleida. La mostra e...

16. El conflicte d'Ucraïna el 2014: Causes i conseqüències de la crisi

OpenAIRE

Kudryashev, Ivan

2015-01-01

Des de finals de 2013 Ucraïna està vivint una greu crisi. Les tímides i preteses intencions de l’Executiu del país d’aproximar-se a la UE, han provocat un esclat de protestes, que amb el pas del temps han conduït al país a una guerra civil. La decisió del govern de no firmar un acord d’Associació amb la UE, i el posterior anunci d’un acord comercial amb Rússia, ha fet patent la participació d’un nou actor en el conflicte: Rússia. Aquest clima de tensió, de radicalització de les protestes i d’...

Lipoamino acid-based micelles as promising delivery vehicles for monomeric amphotericin B.

Science.gov (United States)

Serafim, Cláudia; Ferreira, Inês; Rijo, Patrícia; Pinheiro, Lídia; Faustino, Célia; Calado, António; Garcia-Rio, Luis

2016-01-30

Lipoamino acid-based micelles have been developed as delivery vehicles for the hydrophobic drug amphotericin B (AmB). The micellar solubilisation of AmB by a gemini lipoamino acid (LAA) derived from cysteine and its equimolar mixtures with the bile salts sodium cholate (NaC) and sodium deoxycholate (NaDC), as well as the aggregation sate of the drug in the micellar systems, was studied under biomimetic conditions (phosphate buffered-saline, pH 7.4) using UV-vis spectroscopy. Pure surfactant systems and equimolar mixtures were characterized by tensiometry and important parameters were determined, such as critical micelle concentration (CMC), surface tension at the CMC (γCMC), maximum surface excess concentration (Γmax), and minimum area occupied per molecule at the water/air interface (Amin). Rheological behaviour from viscosity measurements at different shear rates was also addressed. Solubilisation capacity was quantified in terms of molar solubilisation ratio (χ), micelle-water partition coefficient (KM) and Gibbs energy of solubilisation (ΔGs°). Formulations of AmB in micellar media were compared in terms of drug loading, encapsulation efficiency, aggregation state of AmB and in vitro antifungal activity against Candida albicans. The LAA-containing micellar systems solubilise AmB in its monomeric and less toxic form and exhibit in vitro antifungal activity comparable to that of the commercial formulation Fungizone. Copyright © 2015 Elsevier B.V. All rights reserved.

The SLUGGS survey: a comparison of total-mass profiles of early-type galaxies from observations and cosmological simulations, to ˜4 effective radii

Science.gov (United States)

Bellstedt, Sabine; Forbes, Duncan A.; Romanowsky, Aaron J.; Remus, Rhea-Silvia; Stevens, Adam R. H.; Brodie, Jean P.; Poci, Adriano; McDermid, Richard; Alabi, Adebusola; Chevalier, Leonie; Adams, Caitlin; Ferré-Mateu, Anna; Wasserman, Asher; Pandya, Viraj

2018-06-01

We apply the Jeans Anisotropic Multi-Gaussian Expansion dynamical modelling method to SAGES Legacy Unifying Globulars and GalaxieS (SLUGGS) survey data of early-type galaxies in the stellar mass range 1010 physical processes shaping the mass distributions of galaxies in cosmological simulations are still incomplete. For galaxies with M* > 1010.7 M⊙ in the Magneticum simulations, we identify a significant anticorrelation between total-mass density profile slopes and the fraction of stellar mass formed ex situ (i.e. accreted), whereas this anticorrelation is weaker for lower stellar masses, implying that the measured total-mass density slopes for low-mass galaxies are less likely to be determined by merger activity.

Screening of antifungal susceptibility in cave-dwelling aspergilli and report of an amphotericin B-resistant Aspergillus flavus

Directory of Open Access Journals (Sweden)

Erika L.S. Taylor

2017-09-01

Full Text Available Caves are stable environments that favour the development of several microorganisms. The aspergilli represent a large number of species isolated from caves including strains capable of causing serious invasive opportunistic infections in humans. Considering that caves may harbour resistant strains to many antibiotics, investigation on the response of opportunistic aspergilli, isolated from pristine and tourist caves to antifungal agents and the mechanisms involved in resistance might be clinically relevant. A total of 32 strains of the species Aspergillus candidus, A. flavus, A. fumigatus, A. niger, A. tamarii, and A. terreus were isolated from caves in the iron quadrangle in Brazil. The strains were tested for their susceptibility to amphotericin B (AMB, itraconazole, voriconazole and terbinafine. One strain was analysed for the mechanism involved in the AMB-resistance, i.e., ergosterol content, lipid peroxidation and enzymatic activity of the antioxidant system. Terbinafine minimum inhibitory concentrations (MICs ranged between 0.003 and 1.0 µg/mL; voriconazole MICs ranged between 2.0 and >16.0 µg/mL; itraconazole MICs ranged between 0.25 and 8.0 µg/mL and amphotericin B MICs ranged between 0.03 and 4.0 µg/mL. The AMB-resistant strain of A. flavus was detected with MIC value of 4 µg/mL. Resistance to AMB relied on higher ergosterol levels and increased enzymatic activity of the peroxidase and superoxide-dismutase, with lower lipid peroxidation. These results enhance the knowledge of natural antifungal resistance in the subterranean ecosystem, and broaden the knowledge about the subterranean microbiota.

Acrophialophora fusispora Brain Abscess in a Child with Acute Lymphoblastic Leukemia: Review of Cases and Taxonomy

Science.gov (United States)

Al-Mohsen, I. Z.; Sutton, D. A.; Sigler, L.; Almodovar, E.; Mahgoub, N.; Frayha, H.; Al-Hajjar, S.; Rinaldi, M. G.; Walsh, T. J.

2000-01-01

A 12-year-old girl with acute lymphoblastic leukemia was referred to King Faisal Specialist Hospital and Research Center. The diagnosis without central nervous system (CNS) involvement was confirmed on admission, and chemotherapy was initiated according to the Children Cancer Group (CCG) 1882 protocol for high-risk-group leukemia. During neutropenia amphotericin B (AMB) (1 mg/kg of body weight/day) was initiated for presumed fungal infection when a computed tomography (CT) scan of the chest revealed multiple nodular densities. After 3 weeks of AMB therapy, a follow-up chest CT revealed progression of the pulmonary nodules. The patient subsequently suffered a seizure, and a CT scan of the brain was consistent with infarction or hemorrhage. Because of progression of pulmonary lesions while receiving AMB, antifungal therapy was changed to liposomal AMB (LAMB) (6 mg/kg/day). Despite 26 days of LAMB, the patient continued to have intermittent fever, and CT and magnetic resonance imaging of the brain demonstrated findings consistent with a brain abscess. Aspiration of brain abscess was performed and the Gomori methenamine silver stain was positive for hyphal elements. Culture of this material grew Acrophialophora fusispora. Lung biopsy showed necrotizing fungal pneumonia with negative culture. The dosage of LAMB was increased, and itraconazole (ITRA) was added; subsequently LAMB was discontinued and therapy was continued with ITRA alone. The patient demonstrated clinical and radiological improvement. In vitro, the isolate was susceptible to low concentrations of AMB and ITRA. A. fusispora is a thermotolerant, fast-growing fungus with neurotropic potential. We report the first case of human infection involving the CNS. Acrophialophora resembles Paecilomyces but differs in having colonies that become dark and in the development of phialides along the sides or at the tips of echinulate brown conidiophores. Conidia are borne in long chains and are smooth or ornamented with

Exhaled carbon monoxide: a non-invasive biomarker of short-term exposure to outdoor air pollution

Directory of Open Access Journals (Sweden)

Herve Lawin

2017-04-01

Full Text Available Abstract Background In urban settings of Africa with rapidly increasing population, traffic-related air pollution is a major contributor to outdoor air pollution (OAP. Although OAP has been identified as a leading cause of global morbidity and mortality, there is however, lack of a simple biomarker to assess levels of exposure to OAP in resource-poor settings. This study evaluated the role of exhaled carbon monoxide (exhCO as a potential biomarker of exposure to ambient carbon monoxide (ambCO from OAP. Methods This was a descriptive study conducted among male commercial motorcycle riders in Cotonou – the economic capital of Benin. The participants’ AmbCO was measured using a portable carbon monoxide (CO data logger for 8 h during the period of their shift. ExhCO was measured just before and immediately after their shift (8-h Participants were asked not to cook or to smoke during the day of the measurements. Linear regression analysis was used to assess the association between ambCO and exhCO for the last 2, 4 and 6 h of their shift. Results Of 170 participants who completed the study, their mean ± SD age was 42.2 ± 8.4 years, and their mean ± SD daily income was 7.3 ± 2.7$. Also, 95% of the participants’ used solid fuels for cooking and only 2% had ever smoked. Average exhCO increased by 5.1 ppm at the end of the shift (p = 0.004. Post-shift exhCO was significantly associated to ambCO, this association was strongest for the last 2 h of OAP exposure before exhCO measurement (β = 0.34, p < 0.001. Conclusion ExhCO level was associated with recent exposure to ambCO from OAP with measurable increase after 8 h of exposure. These findings suggest that ExhCO may be a potential biomarker of short-term exposure to OAP.

Projecte d'implantació d'energia solar fotovoltaica al municipi d'Albanyà

OpenAIRE

Molins i Galas, Albert

2008-01-01

Disseny d’una instal·lació d’energia solar fotovoltaica per als edificis públics del municipi d’Albanyà (Alt Empordà) per connectar-la a la xarxa i amb un estudi sobre la substitució dels actuals fanals de l’enllumenat públic per fanals alimentats amb energia solar fotovoltaica

Anti-osteoporosis activity of Astragalus membranaceus Bunge ...

African Journals Online (AJOL)

Method: Female Sprague-Dawley rats were randomly divided into six groups: control group, ovariectomy (OVX) with vehicle group, OVX with 17β-estradiol (E2, 25 μg/kg/day) group, and OVX with AMBE doses (60, 120 ... Conclusion: The findings of this study indicate that AMBE prevents OVX-induced osteoporosis in rats.

Utilization of carbon 13-labelled stable isotopes for studying drug toxicity on cellular metabolism

International Nuclear Information System (INIS)

Herve, M.; Wietzerbin, J.; Tran-Dinh, S.

1994-01-01

A new approach for studying the effects of two drugs, amphotericine B (AMB), an anti-fungal antibiotic, and 2-deoxy-D-glucose (DG), on the glucose metabolism in brewer yeast cells (Saccharomyces cerevisiae), is presented; AMB interacts with the membrane sterols, inducing formation of pores through which ions and small molecules can pass. DG may enter in the cytosol, where it is phosphoryled by hexokinase into deoxy-D-glucose 6-phosphate (DG6P) which disappears very slowly. DG slows down the glycolysis process and induces the formation of new substances. This paper shows the advantages of utilizing carbon 13-labelled substrates combined to the NMR-13C and NMR-1H techniques. 6 figs., 5 refs

Novel oral amphotericin B formulation (iCo-010) remains highly effective against murine systemic candidiasis following exposure to tropical temperature.

Science.gov (United States)

Wasan, Kishor M; Sivak, Olena; Bartlett, Karen; Wasan, Ellen K; Gershkovich, Pavel

2015-01-01

To evaluate the antifungal activity of amphotericin B (AmB) in a mouse model of systemic candidiasis following administration of a novel oral AmB formulation (iCo-010) that has been pre-exposed to tropical temperatures. Amphotericin B (AmB) was prepared as a 5 mg/mL dispersion in a mixture of Peceol, Gelucire 44/14 and VitE-TPGS 2,3 (iCo-010). The formulation was protected from light and incubated in a sealed container at 43 °C for 60 days. Mice infected with Candida albicans were treated with either iCo-010 formulation pre-incubated at 43 °C for 60 days or freshly prepared iCo-010 formulation at doses of 5, 10 and 20 mg/kg once daily for five consecutive days. Single intravenous 5 mg/kg dose of AmBisome® was used as a positive control group. Seven days following the last dose, the kidney, liver, spleen, lung, heart and brain were removed and the number of colony forming units (CFUs) was determined as a measure of tissue fungal load. In addition, the concentration of AmB within each tissue was determined using high performance liquid chromatography (HPLC). There were no significant differences in the reduction of CFUs and the concentration of AmB recovered in all organs at all iCo-010 doses tested between the freshly prepared iCo-010 formulation compared to the formulation that was incubated at 43 °C for 60 days. A novel oral AmB formulation, iCo-010, incubated at 43 °C for 60 days to simulate the exposure of the formulation to tropical temperatures remained highly effective against murine systemic candidiasis.

Bon Pastor (Barcelona un territori en construcció

Directory of Open Access Journals (Sweden)

Xavier Salas Ramos

2016-04-01

Full Text Available L'article desenvolupa alguns dels aspectes de la tesi doctoral de l'autor (Sales, 2015. Es planteja una anàlisi de l'evolució del territori en el qual es troba el barri del Bon Pastor (Barcelona, posant l'accent en l'entorn construït. Per a això, la narrativa històrica es complementa amb documentació gràfica, part d'ella a partir dels diversos tallers de participació que l'autor ha desenvolupat i continua desenvolupant-se en aquest barri, en cooperació amb l'Associació de Veïns i l'Ajuntament de Barcelona (Districte de Sant Andreu amb l'objectiu de desenvolupar intervencions en l'espai públic de la zona en relació amb la preservació de la memòria cívica de Bon Pastor i en el context d'avançar en els processos de governaza urbana basada en la participació creativa dels veïns  Alhora s'organitzaven els primers processos participatius, vam començar a documentar la història de Bon Pastor. També a fer rutes pel barri per veure les seves característiques urbanes actuals i recopilar informació sobre els plans urbanístics vigents. Els següents paràgrafs són una síntesi del relat literari de la història de Bon Pastor i les seves principals característiques urbanes. Com va succeir amb Baró de Viver, és un relat que s'haurà d'anar completant a mesura que es desenvolupin els diferents processos participatius amb els relats de les vivències de la població, així com la diferent documentació que ens puguin aportar

Pensar la in/visibilitat. Papers de treball

Directory of Open Access Journals (Sweden)

Meri Torras

2011-01-01

Full Text Available Aquest text recull uns papers de treball al voltant de la in/visibilitat, amb el propòsit de revisar una categoria que ha creuat la trajectòria d’existència lèsbica, gai, queer, així com la teorització i el pensament a propòsit d’aquestes subjectivitats (i de la seva pròpia subjecció. L’associació de la visibilitat amb l’existència ha constituit un axioma. No obstant, la visibilitat no és sempre necessàriament la millor manera de fer-se visible o, immediatament, la millor estratègia política per a l’afirmació de la nostra existència. En aquests papers de treball parteixo de la formulació d’unes hipòtesis/propostes de reflexió, per continuar dialogant amb el volum Manifiestos gays, lesbianos, queer. Testimonios de una lucha (1969-1994, editat per Rafael M. Mérida, i acabo amb un breu testimoni de l’escriptora catalana Maria Mercè Marçal.

Structure design and simulation research of active magnetic bearing for helium centrifugal cold compressor

Science.gov (United States)

Y Zhang, S.; Pan, W.; Wei, C. B.; Wu, J. H.

2017-12-01

Helium centrifugal cold compressors are utilized to pump gaseous helium from saturated liquid helium tank to obtain super-fluid helium in cryogenic refrigeration system, which is now being developed at TIPC, CAS. Active magnetic bearing (AMB) is replacing traditional oil-fed bearing as the optimal supporting assembly for cold compressor because of its many advantages: free of contact, high rotation speed, no lubrication and so on. In this paper, five degrees of freedom for AMB are developed for the helium centrifugal cold compressor application. The structure parameters of the axial and radial magnetic bearings as well as hardware and software of the electronic control system is discussed in detail. Based on modal analysis and critical speeds calculation, a control strategy combining PID arithmetic with other phase compensators is proposed. Simulation results demonstrate that the control method not only stables AMB system but also guarantees good performance of closed-loop behaviour. The prior research work offers important base and experience for test and application of AMB experimental platform for system centrifugal cold compressor.

Lindernia procumbens (Krock.) Borbás

Czech Academy of Sciences Publication Activity Database

Píšová, Soňa; Šumberová, Kateřina; Hroudová, Zdenka

2013-01-01

Roč. 48, č. 1 (2013), s. 97-98 ISSN 1211-5258 R&D Projects: GA MŠk 7AMB12AT015 Institutional support: RVO:67985939 Keywords : endangered species * new locality * wetlands Subject RIV: EF - Botanics

Study for correction of neutron scattering in the calibration of the albedo individual monitor from the Neutron Laboratory (LN), IRD/CNEN-RJ, Brazil

International Nuclear Information System (INIS)

Freitas, B.M.; Silva, A.X. da

2014-01-01

The Instituto de Radioprotecao e Dosimetria (IRD) runs a neutron individual monitoring service with albedo type monitor and thermoluminescent detectors (TLD). Moreover the largest number of workers exposed to neutrons in Brazil is exposed to 241 Am-Be fields. Therefore a study of the response of albedo dosemeter due to neutron scattering from 241 Am-Be source is important for a proper calibration. In this work, it has been evaluated the influence of the scattering correction in two distances at the Low Scattering Laboratory of the Neutron Laboratory of the Brazilian National Laboratory (Lab. Nacional de Metrologia Brasileira de Radiacoes Ionizantes) in the calibration of that albedo dosemeter for a 241 Am-Be source. (author)

Successful Treatment of Candida parapsilosis Fungemia in Two Preterms with Voriconazole

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Emel Altuncu

2015-01-01

Full Text Available Herein, we report two preterms with invasive candidiasis refractory to liposomal amphotericin B (AMB treatment in spite of low MIC levels (MIC: 0.5 mcg/mL. Both of the patients’ blood cultures were persistently positive for C. parapsilosis despite high therapeutic doses (AMB: 7 mg/kg per day. After starting voriconazole blood cultures became negative and both of the patients were treated successfully without any side effects. In conclusion, although it is not a standard treatment in neonatal patients, our limited experience with these patients suggests that voriconazole appears to be a safe antifungal agent to be used in critically ill preterm infants with persistent fungemia despite AMB treatment.

Editorial

OpenAIRE

Menéndez Varela, José Luis

2015-01-01

Aquest número comença amb l´article de Mireia Alcón i José Luis Menéndez sobre el paradigma de l´avaluació autèntica i la contribució específica de les rúbriques al disseny i implantació de sistemes d´avaluació coherents amb el paradigma esmentat. La literatura especialitzada ha insistit en la vinculació de l´avaluació autèntica amb la idea d´una avaluació posada al servei de l´aprenentatge. Així ho demostra l´èmfasi en que l´avaluació se centri en l´acompliment dels estudiants respect...

16. EL CONFLICTE D'UCRAÏNA EL 2014: CAUSES I CONSEQÜÈNCIES DE LA CRISI

OpenAIRE

Kudryashev, Ivan

2015-01-01

Des de finals de 2013 Ucraïna està vivint una greu crisi. Les tímides i preteses intencions de l’Executiu del país d’aproximar-se a la UE, han provocat un esclat de protestes, que amb el pas del temps han conduït al país a una guerra civil. La decisió del govern de no firmar un acord d’Associació amb la UE, i el posterior anunci d’un acord comercial amb Rússia, ha fet patent la participació d’un nou actor en el conflicte: Rússia.Aquest clima de tensió, de radicalització de les protestes i d’i...

Minimal RED Cell Pairs Markedly Improve Electrode Kinetics and Power Production in Microbial Reverse Electrodialysis Cells

KAUST Repository

Cusick, Roland D.

2013-12-17

Power production from microbial reverse electrodialysis cell (MRC) electrodes is substantially improved compared to microbial fuel cells (MFCs) by using ammonium bicarbonate (AmB) solutions in multiple RED cell pair stacks and the cathode chamber. Reducing the number of RED membranes pairs while maintaining enhanced electrode performance could help to reduce capital costs. We show here that using only a single RED cell pair (CP), created by operating the cathode in concentrated AmB, dramatically increased power production normalized to cathode area from both acetate (Acetate: from 0.9 to 3.1 W/m 2-cat) and wastewater (WW: 0.3 to 1.7 W/m2), by reducing solution and charge transfer resistances at the cathode. A second RED cell pair increased RED stack potential and reduced anode charge transfer resistance, further increasing power production (Acetate: 4.2 W/m2; WW: 1.9 W/m2). By maintaining near optimal electrode power production with fewer membranes, power densities normalized to total membrane area for the 1-CP (Acetate: 3.1 W/m2-mem; WW: 1.7 W/m2) and 2-CP (Acetate: 1.3 W/m2-mem; WW: 0.6 W/m2) reactors were much higher than previous MRCs (0.3-0.5 W/m2-mem with acetate). While operating at peak power, the rate of wastewater COD removal, normalized to reactor volume, was 30-50 times higher in 1-CP and 2-CP MRCs than that in a single chamber MFC. These findings show that even a single cell pair AmB RED stack can significantly enhance electrical power production and wastewater treatment. © 2013 American Chemical Society.

Minimal RED Cell Pairs Markedly Improve Electrode Kinetics and Power Production in Microbial Reverse Electrodialysis Cells

KAUST Repository

Cusick, Roland D.; Hatzell, Marta; Zhang, Fang; Logan, Bruce E.

2013-01-01

Power production from microbial reverse electrodialysis cell (MRC) electrodes is substantially improved compared to microbial fuel cells (MFCs) by using ammonium bicarbonate (AmB) solutions in multiple RED cell pair stacks and the cathode chamber. Reducing the number of RED membranes pairs while maintaining enhanced electrode performance could help to reduce capital costs. We show here that using only a single RED cell pair (CP), created by operating the cathode in concentrated AmB, dramatically increased power production normalized to cathode area from both acetate (Acetate: from 0.9 to 3.1 W/m 2-cat) and wastewater (WW: 0.3 to 1.7 W/m2), by reducing solution and charge transfer resistances at the cathode. A second RED cell pair increased RED stack potential and reduced anode charge transfer resistance, further increasing power production (Acetate: 4.2 W/m2; WW: 1.9 W/m2). By maintaining near optimal electrode power production with fewer membranes, power densities normalized to total membrane area for the 1-CP (Acetate: 3.1 W/m2-mem; WW: 1.7 W/m2) and 2-CP (Acetate: 1.3 W/m2-mem; WW: 0.6 W/m2) reactors were much higher than previous MRCs (0.3-0.5 W/m2-mem with acetate). While operating at peak power, the rate of wastewater COD removal, normalized to reactor volume, was 30-50 times higher in 1-CP and 2-CP MRCs than that in a single chamber MFC. These findings show that even a single cell pair AmB RED stack can significantly enhance electrical power production and wastewater treatment. © 2013 American Chemical Society.

Large Mass Flux Differences for Opposite Flow Directions of a Condensable Gas through an Asymmetric Porous Membrane

Czech Academy of Sciences Publication Activity Database

Uchytil, Petr; Loimer, T.

2014-01-01

Roč. 470, NOV 15 (2014), s. 451-457 ISSN 0376-7388 R&D Projects: GA MŠk 7AMB12AT010; GA MŠk(CZ) 7AMB14AT011 Institutional support: RVO:67985858 Keywords : condensation * vapor permeation * asymmetric membrane s Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 5.056, year: 2014

Influence of the Flow Direction on the Mass Transport of Vapors through Membranes Consisting of Several Layers

Czech Academy of Sciences Publication Activity Database

Loimer, T.; Uchytil, Petr

2015-01-01

Roč. 67, OCT 2015 (2015), s. 2-5 ISSN 0894-1777 R&D Projects: GA MŠk 7AMB12AT010; GA MŠk(CZ) 7AMB14AT011 Institutional support: RVO:67985858 Keywords : porous media * phase change * vapor flow Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 2.128, year: 2015

First record of Rhizoscyphus ericae in Southern Hemisphere´s Ericaceae

Czech Academy of Sciences Publication Activity Database

Bruzone, M. C.; Fehrer, Judith; Fontenla, S. B.; Vohník, Martin

2017-01-01

Roč. 27, č. 2 (2017), s. 147-163 ISSN 0940-6360 R&D Projects: GA MŠk(CZ) 7AMB14AR003; GA MŠk 7AMB12AR014 Institutional support: RVO:67985939 Keywords : ericoid mycorrhiza * Rhizoscipus Ericae * Southern Hemisphere Subject RIV: EH - Ecology, Behaviour OBOR OECD: Ecology Impact factor: 3.047, year: 2016

Instal·lació i configuració d'aules d'informàtica a un institut

OpenAIRE

González Canet, Alicia

2013-01-01

Instal·lació i configuració d'aules d'informàtica a un institut amb Ubuntu 12.04 i gestió de la xarxa amb MikroTik. Instalación y configuración de aulas de informática en un instituto con Ubuntu 12.04 y gestión de la red con MikroTik.

Polítiques d’habitatge sostenible a Dinamarca

DEFF Research Database (Denmark)

Jørgensen, Michael Søgaard

2011-01-01

relacionades amb l’habitatge sostenible, centrades tant en la construcció de nous habitatges, com en la rehabilitació del parc existent. Finalment, es mostren algunes experiències recents per a la defensa del medi ambient del Taller de la Ciència de la Universitat Tecnològnica de Dinamarca en col·laboració amb...

Design and Experiment of Auxiliary Bearing for Helium Blower of HTR-PM

International Nuclear Information System (INIS)

Yang Guojun; Shi Zhengang; Liu Xingnan; Zhao Jingjing

2014-01-01

The helium blower is the important equipment for HTR-PM. Active magnetic bearing (AMB) instead of mechanical bearing is selected to support the rotor of the helium blower. However, one implication of AMB is the requirement to provide the auxiliary bearing to mitigate the effects of failures or overload conditions. The auxiliary bearing is used to support the rotor when the AMB fails to work. It must support the dropping rotor and bear the great impact force and friction heat. The design of the auxiliary bearing is one of the challenging problems in the whole system. It is very important for the helium blower with AMB of HTR-PM to make success. The rotor’s length of helium blower of HTR-PM is about 3.3 m, its weight is about 4000 kg and the rotating speed is 4000 r/min. The axial load is 4500kg, and the radial load is 1950kg. The angular contact ball bearing was selected as the auxiliary bearing. The test rig has been finished. It is difficult to analyze the falling course of the rotor. The preliminary analysis of the dropping rotor was done in the special condition. The impact force of auxiliary bearing was computed for the axial and radial load. And the dropping test of the blower rotor for HTR-10 will be introduced also in this paper. Results offer the important theoretical base for the protector design of the helium blower with AMB for HTR-PM. (author)

Targeting the Oxidative Stress Response System of Fungi with Redox-Potent Chemosensitizing Agents

Science.gov (United States)

Kim, Jong H.; Chan, Kathleen L.; Faria, Natália C. G.; Martins, M. de L.; Campbell, Bruce C.

2012-01-01

The cellular antioxidant system is a target in the antifungal action of amphotericin B (AMB) and itraconazole (ITZ), in filamentous fungi. The sakAΔ mutant of Aspergillus fumigatus, a mitogen-activated protein kinase (MAPK) gene deletion mutant in the antioxidant system, was found to be more sensitive to AMB or ITZ than other A. fumigatus strains, a wild type and a mpkCΔ mutant (a MAPK gene deletion mutant in the polyalcohol sugar utilization system). Complete fungal kill (≥99.9%) by ITZ or AMB was also achieved by much lower dosages for the sakAΔ mutant than for the other strains. It appears msnA, an Aspergillus ortholog to Saccharomyces cerevisiae MSN2 (encoding a stress-responsive C2H2-type zinc-finger regulator) and sakA and/or mpkC (upstream MAPKs) are in the same stress response network under tert-butyl hydroperoxide (t-BuOOH)-, hydrogen peroxide (H2O2)- or AMB-triggered toxicity. Of note is that ITZ-sensitive yeast pathogens were also sensitive to t-BuOOH, showing a connection between ITZ sensitivity and antioxidant capacity of fungi. Enhanced antifungal activity of AMB or ITZ was achieved when these drugs were co-applied with redox-potent natural compounds, 2,3-dihydroxybenzaldehyde, thymol or salicylaldehyde, as chemosensitizing agents. We concluded that redox-potent compounds, which target the antioxidant system in fungi, possess a chemosensitizing capacity to enhance efficacy of conventional drugs. PMID:22438852

Activation analysis of some seaweeds of Myanmar

Energy Technology Data Exchange (ETDEWEB)

Myint, U; Myint, Aye Myint [Yangon Univ. (Myanmar). Dept. of Chemistry

1994-11-01

Activation analysis of some seaweed samples occurring off the coastline areas of Myanmar is described. Na, K and I were determined using Am(Be) radionuclide neutron source and low level [beta]-counting. (author) 3 refs.; 1 fig.; 2 tabs.

Determination of gold in some Myanmar indigenous medicines by neutron activation analysis

International Nuclear Information System (INIS)

Myint U.; Sein Sein Yi

1995-01-01

Gold has been determined in two Myanmar indigenous medicines TMF 14 (Devaauthada), TMF 15 (Shwe Thwe Say) by neutron activation analysis using an Am(Be) radionuclide neutron source. The activity of 411 keV of the 198 Au has been measured. (author). 2 refs., 1 fig., 1 tab

Anisotropy of neutrons sources of the Neutron Metrology Laboratory

International Nuclear Information System (INIS)

Silva, A.C.F.; Silva, F.S.; Creazolla, P.G.; Patrão, K.C.S.; Fonseca, E.S. da; Pereira, W.W.

2017-01-01

The anisotropy measurements have as main objective to define the emission of the radiation by different angles of an encapsulated neutron source. Measurements were performed using a Precision Long Counter (PLC) detector in the Laboratório de Baixo Espalhamento of the LNMRI / IRD. In this study were used an 241 AmBe (α,n) 5.92 GBq and a 238 PuBe (α,n) 1.85 TBq. The anisotropy factor was 8.65% to 241 AmBe and 4.36% to 238 PuBe, due to variations in the source encapsulation. The results in this work will focus mainly on the area of radiation protection and studies that will improve the process of routine measurements in laboratories and instrument calibrations. (author)

Anisotropy of neutrons sources of the Neutron Metrology Laboratory; Anisotropia de fontes de nêutrons do Laboratório de Metrologia de Nêutrons

Energy Technology Data Exchange (ETDEWEB)

Silva, A.C.F., E-mail: alexander.camargo@oi.com.br [Fundação Técnico Educacional Souza Marques, Rio de Janeiro, RJ (Brazil); Silva, F.S.; Creazolla, P.G.; Patrão, K.C.S.; Fonseca, E.S. da; Pereira, W.W. [Instituto de Radioproteção e Dosimetria (LNMRI/IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Laboratório Nacional de Metrologia das Radiações Ionizantes

2017-07-01

The anisotropy measurements have as main objective to define the emission of the radiation by different angles of an encapsulated neutron source. Measurements were performed using a Precision Long Counter (PLC) detector in the Laboratório de Baixo Espalhamento of the LNMRI / IRD. In this study were used an {sup 241}AmBe (α,n) 5.92 GBq and a {sup 238}PuBe (α,n) 1.85 TBq. The anisotropy factor was 8.65% to {sup 241}AmBe and 4.36% to {sup 238}PuBe, due to variations in the source encapsulation. The results in this work will focus mainly on the area of radiation protection and studies that will improve the process of routine measurements in laboratories and instrument calibrations. (author)

Determination of manganese in some pyrolusite ores of Myanmar by neutron activation analysis

International Nuclear Information System (INIS)

Myint, U.; Swe, M.T.

1994-01-01

Manganese in pyrolusite ores from various regions of Myanmar was determined by thermal neutron activation analysis using an Am(Be) neutron source. The induced activities of 56 Mn were monitored by a γ-counting technique. (author) 2 refs.; 1 tab

Determination of manganese in some pyrolusite ores of Myanmar by neutron activation analysis

Energy Technology Data Exchange (ETDEWEB)

Myint, U; Swe, M T [Yangon Univ. (Myanmar). Dept. of Chemistry

1994-05-17

Manganese in pyrolusite ores from various regions of Myanmar was determined by thermal neutron activation analysis using an Am(Be) neutron source. The induced activities of [sup 56]Mn were monitored by a [gamma]-counting technique. (author) 2 refs.; 1 tab.

Two-Fluid 2.5D MHD-Code for Simulations in the Solar Atmosphere

Czech Academy of Sciences Publication Activity Database

Piantschitsch, I.; Amerstorfer, U.; Thalmann, J.; Utz, D.; Hanslmeier, A.; Bárta, Miroslav; Thonhofer, S.; Lemmerer, B.

2014-01-01

Roč. 38, č. 1 (2014), s. 59-66 ISSN 1845-8319 R&D Projects: GA MŠk(CZ) 7AMB14AT022 Institutional support: RVO:67985815 Keywords : MHD simulation * chromosphere * reconnection Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

Ruralserv: Un instrumento de medición de la calidad del servicio en alojamientos rurales con autenticidad local

OpenAIRE

Cuellar Salazar, Maria Sonia

2009-01-01

Màster tesi què pretén determinar quins atributs han de ser considerats per a mesurar la qualitat del servei en establiments rurals amb autenticitat local. Proposa un nou instrument de medició, que l’autor ha anomenat RURALSERV. Se segueix el model SERVQUAL, però amb un format de mesura basat exclusivament en la percepció del visitant

Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast

Czech Academy of Sciences Publication Activity Database

Rinnerthaler, M.; Büttner, S.; Laun, P.; Heeren, G.; Felder, T. K.; Klinger, H.; Weinberger, M.; Stolze, K.; Groušl, Tomáš; Hašek, Jiří; Benada, Oldřich; Frýdlová, Ivana; Klocker, A.; Simon-Nobbe, B.; Jansko, B.; Breitenbach-Koller, B.; Eisenberg, T.; Gourlay, C. W.; Madeo, F.; Burhans, W. C.; Breitenbach, M.

2012-01-01

Roč. 109, č. 22 (2012), s. 8658-8663 ISSN 0027-8424 R&D Projects: GA ČR GA204/09/1924; GA MŠk MEB060902; GA MŠk 7AMB12AT002; GA MŠk LC545 Institutional research plan: CEZ:AV0Z50200510 Keywords : cell cycle * integral membrane reductase * wiskostatin Subject RIV: EE - Microbiology, Virology Impact factor: 9.737, year: 2012

A verification plan of rotor dynamics of turbo-machine system supported by AMB for the GTHTR300 (step 1)

International Nuclear Information System (INIS)

Takizuka, Takakazu; Takada, Shoji; Kosugiyama, Shinichi; Kunitomi, Kazuhiko; Xing, Yan

2003-01-01

A program for research and development on magnetic bearing suspended rotor dynamics was planned for the Gas Turbine High Temperature Reactor (GTHTR300) plant. The magnetic bearing to suspend the turbo-machine rotor of GTHTR300 is unique because the required load capacity is much larger than that of existing one. The turbo-compressor and generator rotors, each of which is suspended by two radial bearings, pass over the first and the second critical speeds to bending mode, respectively. The rotor design fulfilled the standard limit of vibration amplitude of 75 μm at the rated rotational speed by optimising the stiffness of the magnetic bearings. A test apparatus was designed in the program. The test apparatus is composed of 1/3-scale two test rotors simulating turbo-compressor and generator rotors which are connected by a flexible coupling or a rigid coupling. Because the load capacity is almost in proportion to the projected area of the bearing, the load capacity of the magnetic bearing is almost 1/10 of the actual one. The test rotors were designed so that their critical speeds and vibration modes match the actual ones. The test will verify the rotor design and demonstrate the rotor vibration control technology of the magnetic bearing. This paper shows the outline of the test device and the test plan for the magnetic bearing suspended rotor system. The present study is entrusted from the Ministry of Education, Culture, Sports, Science and Technology of Japan. (author)

eBook: Temps líquids per a les biblioteques públiques

Directory of Open Access Journals (Sweden)

Juan Soriano, Emili

2012-06-01

Full Text Available Què fem amb els llibres electrònics?, és la pregunta que s’estan plantejant molts bibliotecaris mentre assisteixen perplexos a una competició frenètica sobre la distribucióde continguts digitals i a la cursa accelerada de les empreses tecnològiques per presentar dispositius de lectura electrònica amb més prestacions.La resposta no és senzilla, per això, les biblioteques públiques contemplen aquesta nova realitat amb un cert neguit, i alhora, com un nou repte per continuar sent una institució cultural central en la vida de les persones posicionant-se i adaptant els serveis i els continguts a les noves demandes dels usuaris, tenint present que, a dia de hui, el món digital i el món imprès no són excloents sinó complementaris.El present article intenta analitzar aquesta nova realitat i planteja algunes de les accions a adoptar per part de les biblioteques públiques amb les incerteses pròpies dels “tempslíquids” que travessa la nostra societat.

[RAGWEED ALLERGY IN THE SOUTH OF RUSSIA - IN THE CHECHEN REPUBLIC].

Science.gov (United States)

Macharadze, D; Janaeva, H; Avilov, K

2017-05-01

Allergy to ragweed pollen and other weeds is a global problem due to the rapid spread of these grasses around the world. In addition, pollen of short ragweed (Ambrosia, Amb) and mugwort (Artemisia, Art) - one of the main causes of respiratory allergy - seasonal allergic rhinoconjunctivitis (hay fever) with/without bronchial asthma patients living in the South of Russia. Epidemiological studies on the prevalence of Allergy to Amb and Art among patients living in Chechen Republic, absent. Aim - of this retrospective study was to investigate the prevalence of sensitization to weed pollen in patients of Chechnya. We surveyed аllergy (skin prick tests with 13 inhalant allergens) from 845 patients aged 4-68 years, in Urus-Martan for the period 2013-2016 yrs. Polisensitization was defined as the presence of positive skin tests to 2 or more extracts of different groups of allergens. ~26% and 21% of patients in the Chechen Republic have an allergy to Amb and Art, respectively. Further studies at the molecular level will help to establish the geographical variation of the sensitization profile to the major component of Amb and Art, which could have clinical significance in the proper selection of specific immunotherapy.

Significance of Algal Polymer in Designing Amphotericin B Nanoparticles

Directory of Open Access Journals (Sweden)

Saurabh Bhatia

2014-01-01

Full Text Available Development of oral amphotericin B (AmB loaded nanoparticles (NPs demands a novel technique which reduces its toxicity and other associated problems. Packing of AmB in between two oppositely charged ions by polyelectrolyte complexation technique proved to be a successful strategy. We have developed a novel carrier system in form of polyelectrolyte complex of AmB by using chitosan (CS and porphyran (POR as two oppositely charged polymers with TPP as a crosslinking agent. Initially POR was isolated from Porphyra vietnamensis followed by the fact that its alkali induced safe reduction in molecular weight was achieved. Formulation was optimized using three-factor three-level (33 central composite design. High concentration of POR in NPs was confirmed by sulfated polysaccharide (SP assay. Degradation and dissolution studies suggested the stability of NPs over wide pH range. Hemolytic toxicity data suggested the safety of prepared formulation. In vivo and in vitro antifungal activity demonstrated the high antifungal potential of optimized formulation when compared with standard drug and marketed formulations. Throughout the study TPP addition did not cause any significant changes. Therefore, these experimental oral NPs may represent an interesting carrier system for the delivery of AmB.

Magnetostatic analysis of a rotor system supported by radial active magnetic bearings

Directory of Open Access Journals (Sweden)

Ferfecki P.

2009-06-01

Full Text Available The development and the design of a radial active magnetic bearing (AMB reflects a complex process of the multidisciplinary rotor dynamics, electromagnetism and automatic control analysis. Modelling is performed by application of the physical laws from different areas, e.g. Newton's laws of motion and Maxwell's equations. The new approach in the numerical modelling of radial AMB and design methodology allowing automatic generation of primary dimensions of the radial AMB is proposed. Instead of the common way of computation of electromagnetic forces by linearizing at the centre position of the rotor with respect to rotor displacement and coil current, the finite element computation of electromagnetic forces is used. The heteropolar radial AMB consisting of eight pole shoes was designed by means of the built up algorithms for rotor system with two discs fixed on the cantilever shaft. A study of the influence of the nonlinear magnetization characteristics of a rotor and stator material on the equilibrium position of a rotor system is carried out. The performed numerical study shows that results obtained from the analytical nonlinear relation for electromagnetic forces can be considerably different from forces computed with magnetostatic finite element analysis.

Is the prominent ericoid mycorrhizal fungus Rhizoscyphus ericae absent in the Southern Hemisphere’s Ericaceae? A case study on the diversity of root mycobionts in Gaultheria spp. from northwest Patagonia, Argentina

Czech Academy of Sciences Publication Activity Database

Brusone, M. C.; Fontenla, S. B.; Vohník, Martin

2015-01-01

Roč. 25, č. 1 (2015), s. 25-40 ISSN 0940-6360 R&D Projects: GA MŠk 7AMB12AR014 Institutional support: RVO:67985939 Keywords : ericoid mycorrhiza * Gaultheria * Patagonia Subject RIV: EF - Botanics Impact factor: 3.252, year: 2015

L’ensenyament-aprenentatge de la recerca a Llatinoamèrica. Acostament des d’ALAS Costa Rica

Directory of Open Access Journals (Sweden)

José Torres Frías

2018-01-01

Full Text Available El present text inclou l’anàlisi de treballs presentats en el XXX Congreso Latinoamericano de Sociología ALAS Costa Rica, celebrat el 2015, coordinat per l’Asociación Latinoamericana de Sociología (ALAS. Es prenen en consideració vuit treballs relacionats amb el procés d’ensenyament-aprenentatge de la recerca i es recuperen les principals aportacions que han fet sobre el tema. Es discuteix sobre com s’aborda el procés d’ensenyament-aprenentatge de la recerca en el context llatinoamericà. S’evidencia que, malgrat les diferències contextuals i institucionals, a Llatinoamèrica prevalen problemàtiques compartides sobre formació per a la recerca. Alguns dels principals aspectes que es posen de manifest estan relacionats amb la dificultat que tenen els formadors per desenvolupar el procés d’ensenyament-aprenentatge en el marc de les ciències socials i humanitats. Altres aspectes es vinculen amb l’experiència en recerca del formador mateix, amb l’estil que té per dur a terme la seva pròpia recerca i guiar tesis, i amb l’estil de docència que utilitza. També són un factor de rellevància els estils dels estudiants, així com les creences que tots dos actors tenen sobre la formació per a la recerca. Finalment, l’existència o no d'una cultura de recerca s’aprecia com una problemàtica que cal tenir en compte.

Com crear un grup amb Diigo

OpenAIRE

Torres, Begoña; Halbaut, Lyda; Aróztegui Trenchs, Montserrat

2013-01-01

Diigo és un marcador social molt utilitzat actualment ja que és una eina senzilla i molt intuïtiva que et permet emmagatzemar els teus marcadors de forma que es poden consultar des de qualsevol ordinador connectat a la xarxa o crear grups públics o privats per a compartir aquests marcadors. Nosaltres exposarem com crear grups i compartir marcadors.

High Temperature Latent Heat Thermal Energy Storage to Augment Solar Thermal Propulsion for Microsatellites

Science.gov (United States)

2015-08-30

radiosity calculations into the finite difference solutions at the boundary. 7.2.1 Radiation Shielding Integration Radiation shielding was included in the...exterior nodes 1 through n, the radiosity per unit area Bn is calculated as Bn = nσn(T 4 n − T 4amb) + ρnHn (7.1) where is the emissivity, σ is the

Ubiquitination and proteasome-mediated degradation of voltage-gated Ca2+ channels and potential pathophysiological implications

Czech Academy of Sciences Publication Activity Database

Felix, R.; Weiss, Norbert

2017-01-01

Roč. 36, č. 1 (2017), s. 1-5 ISSN 0231-5882 R&D Projects: GA ČR GA15-13556S; GA MŠk 7AMB15FR015 Institutional support: RVO:61388963 Keywords : Ca2+ channels * ubiquitination * UPS * VGCC Subject RIV: CE - Biochemistry OBOR OECD: Biochemistry and molecular biology Impact factor: 1.170, year: 2016

Respiratory water loss during rest and flight in European Starlings (Sturnus vulgaris)

NARCIS (Netherlands)

Engel, Sophia; Suthers, Roderick A.; Biebach, Herbert; Visser, G. Henk

2006-01-01

Respiratory water loss in Starlings (Sturnus vulgaris) at rest and during flight at ambient temperatures (T-amb) between 6 and 25 degrees C was calculated from respiratory airflow and exhaled air temperature. At rest, breathing frequency f(1.4 +/- 0.3 Hz) and tidal volume V-t (1.9 +/- 0.4 ml) were

Efficacy of an oral and tropically stable lipid-based formulation of Amphotericin B (iCo-010) in an experimental mouse model of systemic candidiasis.

Science.gov (United States)

Ibrahim, Fady; Sivak, Olena; Wasan, Ellen K; Bartlett, Karen; Wasan, Kishor M

2013-10-29

An oral lipid based formulation that exhibits tropical stability (iCo-010) was developed to enhance the absorption of orally administered amphotericin B (AmB). iCo-010 has previously shown high efficacy in an acute model of systemic candidiasis in rats, directing the focus of this study to be its efficacy in a chronic model of systemic candidiasis in mice. Mice were infected with 0.6 to 1×108 CFUs of Candida albicans ATCC 18804 strain by tail vein injection and were left for three days to develop the infection after which time treatment was initiated. The infected animals were assigned to the following treatment groups: no treatment (control) or iCo-010 at 5, 10 and 20 mg/kg administered by oral gavage once daily (QD) for 5 consecutive days. The animals were sacrificed 7 days after the last dose and the concentration of AmB and the fungal burden were assessed within the liver, kidneys, heart, lungs, spleen and brain. Although the infection was relatively low (~ 60-100 CFUs/ 1 ml tissue homogenate) in the liver, lungs and heart, the infection level was very high (70 000 CFUs / 1 ml tissue homogenate) in the kidney tissues for the control group. The highest concentrations of AmB were recovered in the kidneys and the spleen. The fungal burden in the tissues was lowered by 69-96% in the treatment groups when compared to the control group. Oral iCo-010 is an effective treatment of systemic candidiasis in the mouse model.

Catalytic degradation of Amlodipine Besylate using ZnO, Cu doped ZnO, and Fe doped ZnO nanoparticles from an aqueous solution: Investigating the effect of different parameters on degradation efficiency

Science.gov (United States)

Alizadeh, Elahe; Baseri, Hadi

2018-04-01

Some common nanoparticles, such as Zinc Oxide have been used as nanocatalysts in many processes, but they also have an important application in water purification processes. In this research, ZnO based nanoparticles were used for the degradation of Amlodipine Besylate (AMB) and the effect of some main parameters, e.g. initial concentration of AMB, nanocatalysts dose, pH of the solution, temperature of the solution, H2O2 dose, and the time of visible light irradiation, were investigated. The destruction amount was determined by UV-Vis spectroscopy. The synthesized nanoparticles were characterized by FE-SEM, XRD, FT-IR, BET, BJH, EDS, XRF and UV-Vis techniques. The maximum degradation of AMB was about 90% in 60 min of visible light irradiation with 100 μL of H2O2.

Gratiola neglecta Torr

Czech Academy of Sciences Publication Activity Database

Šumberová, Kateřina

2013-01-01

Roč. 48, č. 1 (2013), s. 92-93 ISSN 1211-5258 R&D Projects: GA MŠk 7AMB12AT015 Institutional research plan: CEZ:AV0Z60050516 Institutional support: RVO:67985939 Keywords : Neophyte * new locality * wetlands Subject RIV: EF - Botanics

Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation in ERG11 and Exhibiting Cross-Resistance to Azoles and Amphotericin B

NARCIS (Netherlands)

Hull, Claire M.; Parker, Josie E.; Bader, Oliver; Weig, Michael; Gross, Uwe; Warrilow, Andrew G. S.; Kelly, Diane E.; Kelly, Steven L.

We identified a clinical isolate of Candida glabrata (CG156) exhibiting flocculent growth and cross-resistance to fluconazole (FLC), voriconazole (VRC), and amphotericin B (AMB), with MICs of >256, >256, and 32 mu g ml(-1), respectively. Sterol analysis using gas chromatography-mass spectrometry

In vino veritas... Is there truth in wine? Drinking and intemperance in Great Moravian and Early Czech legislation (Antique traditions in the Byzantine and Slavonic world)

Czech Academy of Sciences Publication Activity Database

Havlíková, Lubomíra

2014-01-01

Roč. 72, 1-2 (2014), s. 98-121 ISSN 0007-7712 R&D Projects: GA MŠk 7AMB12SK161 Institutional support: RVO:68378017 Keywords : Great Moravia * Great- Moravian law * Slavonic law * Bohemia * Cyril * Methodius * Byzantium * antique traditions Subject RIV: AB - History

Trafficking of neuronal calcium channels

Czech Academy of Sciences Publication Activity Database

Weiss, Norbert; Zamponi, G. W.

2017-01-01

Roč. 1, č. 1 (2017), č. článku NS20160003. ISSN 2059-6553 R&D Projects: GA ČR GA15-13556S; GA MŠk 7AMB15FR015 Institutional support: RVO:61388963 Keywords : calcium channel * neuron * trafficing Subject RIV: ED - Physiology OBOR OECD: Physiology (including cytology) http://www.neuronalsignaling.org/content/1/1/NS20160003

Neutron beam design for low intensity neutron and gamma-ray radioscopy using small neutron sources

CERN Document Server

Matsumoto, T

2003-01-01

Two small neutron sources of sup 2 sup 5 sup 2 Cf and sup 2 sup 4 sup 1 Am-Be radioisotopes were used for design of neutron beams applicable to low intensity neutron and gamma ray radioscopy (LINGR). In the design, Monte Carlo code (MCNP) was employed to generate neutron and gamma ray beams suited to LINGR. With a view to variable neutron spectrum and neutron intensity, various arrangements were first examined, and neutron-filter, gamma-ray shield and beam collimator were verified. Monte Carlo calculations indicated that with a suitable filter-shield-collimator arrangement, thermal neutron beam of 3,900 ncm sup - sup 2 s sup - sup 1 with neutron/gamma ratio of 7x10 sup 7 , and 25 ncm sup - sup 2 s sup - sup 1 with very large neutron/gamma ratio, respectively, could be produced by using sup 2 sup 5 sup 2 Cf(122 mu g) and a sup 2 sup 4 sup 1 Am-Be(37GBq)radioisotopes at the irradiation port of 35 cm from the neutron sources.

Molecular identification and amphotericin B susceptibility testing of clinical isolates of Aspergillus from 11 hospitals in Korea.

Science.gov (United States)

Heo, Min Seok; Shin, Jong Hee; Choi, Min Ji; Park, Yeon Joon; Lee, Hye Soo; Koo, Sun Hoe; Lee, Won Gil; Kim, Soo Hyun; Shin, Myung Geun; Suh, Soon Pal; Ryang, Dong Wook

2015-11-01

We investigated the species distribution and amphotericin B (AMB) susceptibility of Korean clinical Aspergillus isolates by using two Etests and the CLSI broth microdilution method. A total of 136 Aspergillus isolates obtained from 11 university hospitals were identified by sequencing the internal transcribed spacer (ITS) and β-tubulin genomic regions. Minimal inhibitory concentrations (MICs) of AMB were determined in Etests using Mueller-Hinton agar (Etest-MH) and RPMI agar (Etest-RPG), and categorical agreement with the CLSI method was assessed by using epidemiological cutoff values. ITS sequencing identified the following six Aspergillus species complexes: Aspergillus fumigatus (42.6% of the isolates), A. niger (23.5%), A. flavus (17.6%), A. terreus (11.0%), A. versicolor (4.4%), and A. ustus (0.7%). Cryptic species identifiable by β-tubulin sequencing accounted for 25.7% (35/136) of the isolates. Of all 136 isolates, 36 (26.5%) had AMB MICs of ≥2 μg/mL by the CLSI method. The categorical agreement of Etest-RPG with the CLSI method was 98% for the A. fumigatus, A. niger, and A. versicolor complexes, 87% for the A. terreus complex, and 37.5% for the A. flavus complex. That of Etest-MH was ≤75% for the A. niger, A. flavus, A. terreus, and A. versicolor complexes but was higher for the A. fumigatus complex (98.3%). Aspergillus species other than A. fumigatus constitute about 60% of clinical Aspergillus isolates, and reduced AMB susceptibility is common among clinical isolates of Aspergillus in Korea. Molecular identification and AMB susceptibility testing by Etest-RPG may be useful for characterizing Aspergillus isolates of clinical relevance.

Using long-term ecosystem service and biodiversity data to study the impacts and adaptation options in response to climate change: insights from the global ILTER sites network

Czech Academy of Sciences Publication Activity Database

Vihervaara, P.; D'Amato, D.; Forsius, M.; Angelstam, P.; Baessler, C.; Balvanera, P.; Boldgiv, B.; Bourgeron, P.; Dick, J.; Kanka, R.; Klotz, S.; Maass, M.; Melecis, V.; Petřík, Petr; Shibata, H.; Tang, J.; Thompson, J.; Zacharias, S.

2013-01-01

Roč. 5, č. 1 (2013), s. 53-66 ISSN 1877-3435 R&D Projects: GA MŠk 7AMB12SK156 Institutional support: RVO:67985939 Keywords : climate change * long-term ecological monitoring * prmanen research plot Subject RIV: EF - Botanics Impact factor: 2.758, year: 2013

Understanding Drug Release Data through Thermodynamic Analysis.

Science.gov (United States)

Freire, Marjorie Caroline Liberato Cavalcanti; Alexandrino, Francisco; Marcelino, Henrique Rodrigues; Picciani, Paulo Henrique de Souza; Silva, Kattya Gyselle de Holanda E; Genre, Julieta; Oliveira, Anselmo Gomes de; Egito, Eryvaldo Sócrates Tabosa do

2017-06-13

Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively. Release profiles from the DDSs were performed, and the mathematical modeling of the data was carried out. Activation energy, enthalpy, entropy and Gibbs free energy of the drug release process were determined. AmB release profiles showed that the relationship to overcome the enthalpic barrier was PVA-fiber > PVA-film > PLA-fiber > PLA-film. Drug release kinetics from the fibers and the films were better fitted on the Peppas-Sahlin and Higuchi models, respectively. The thermodynamic parameters corroborate these findings, revealing that the AmB release from the evaluated systems was an endothermic and non-spontaneous process. Thermodynamic parameters can be used to explain the drug kinetic release profiles. Such an approach is of utmost importance for DDS containing insoluble compounds, such as AmB, which is associated with an erratic bioavailability.

El diàleg paradigmàtic en Educació Social: la simulació com una manera d'ensenyar i aprendre en les aules universitàries

Directory of Open Access Journals (Sweden)

José Antonio Caride Gómez

2012-12-01

Full Text Available El text presenta una pràctica de simulació a l'aula, realitzada -en els últims anys- amb estudiants que han cursat l'assignatura de 'Pedagogia Social' a la Diplomatura d'Educació Social i en la Llicenciatura de Pedagogia (ara Graus, a la Facultat de Ciències de l'Educació de la Universitat de Santiago de Compostel la. Amb un enfocament didàctic innovador, en què els alumnes adquireixen un protagonisme directe en els processos d'ensenyament-aprenentatge que es proposen, els seus plantejaments metodològics es projecten en un 'diàleg paradigmàtic' que pren com a referència els tres models de racionalitat teòrica (teories als que sol remetre la Pedagogia-Educació Social: tecnològic, interpretatiu i soci-crític. Generant una dinàmica que implica tot l'alumnat, mitjançant un joc de rols col · lectiu, les teories i els que les 'representen' comprometen seves respectives mirades amb persones i realitats concretes -en aquest cas, la pobresa en les seves dimensions macro i microsocials-, d’una manera participativa i reflexiu, amb nivells d'implicació (des de la lectura fins al debat en grups i desenvolupament dels coneixements molt estimables.

Understanding Drug Release Data through Thermodynamic Analysis

Science.gov (United States)

Freire, Marjorie Caroline Liberato Cavalcanti; Alexandrino, Francisco; Marcelino, Henrique Rodrigues; Picciani, Paulo Henrique de Souza; Silva, Kattya Gyselle de Holanda e; Genre, Julieta; de Oliveira, Anselmo Gomes; do Egito, Eryvaldo Sócrates Tabosa

2017-01-01

Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively. Release profiles from the DDSs were performed, and the mathematical modeling of the data was carried out. Activation energy, enthalpy, entropy and Gibbs free energy of the drug release process were determined. AmB release profiles showed that the relationship to overcome the enthalpic barrier was PVA-fiber > PVA-film > PLA-fiber > PLA-film. Drug release kinetics from the fibers and the films were better fitted on the Peppas–Sahlin and Higuchi models, respectively. The thermodynamic parameters corroborate these findings, revealing that the AmB release from the evaluated systems was an endothermic and non-spontaneous process. Thermodynamic parameters can be used to explain the drug kinetic release profiles. Such an approach is of utmost importance for DDS containing insoluble compounds, such as AmB, which is associated with an erratic bioavailability. PMID:28773009

Neutron activation analysis: Modelling studies to improve the neutron flux of Americium-Beryllium source

Energy Technology Data Exchange (ETDEWEB)

Didi, Abdessamad; Dadouch, Ahmed; Tajmouati, Jaouad; Bekkouri, Hassane [Advanced Technology and Integration System, Dept. of Physics, Faculty of Science Dhar Mehraz, University Sidi Mohamed Ben Abdellah, Fez (Morocco); Jai, Otman [Laboratory of Radiation and Nuclear Systems, Dept. of Physics, Faculty of Sciences, Tetouan (Morocco)

2017-06-15

Americium–beryllium (Am-Be; n, γ) is a neutron emitting source used in various research fields such as chemistry, physics, geology, archaeology, medicine, and environmental monitoring, as well as in the forensic sciences. It is a mobile source of neutron activity (20 Ci), yielding a small thermal neutron flux that is water moderated. The aim of this study is to develop a model to increase the neutron thermal flux of a source such as Am-Be. This study achieved multiple advantageous results: primarily, it will help us perform neutron activation analysis. Next, it will give us the opportunity to produce radio-elements with short half-lives. Am-Be single and multisource (5 sources) experiments were performed within an irradiation facility with a paraffin moderator. The resulting models mainly increase the thermal neutron flux compared to the traditional method with water moderator.

Development of radiometric assays for quantification of enzyme activities of the key enzymes of thyroid hormones metabolism

Czech Academy of Sciences Publication Activity Database

Pavelka, Stanislav

2014-01-01

Roč. 63, Suppl.1 (2014), S133-S140 ISSN 0862-8408 R&D Projects: GA MŠk(CZ) 7AMB12SK158; GA ČR(CZ) GA304/08/0256 Institutional support: RVO:67985823 Keywords : enzyme * metabolism * radiometric assay * thyroid hormone Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition Impact factor: 1.293, year: 2014

It takes two T to shape immunity: emerging role for T-type calcium channels in immune cells

Czech Academy of Sciences Publication Activity Database

Lacinová, L.; Weiss, Norbert

2016-01-01

Roč. 35, č. 4 (2016), s. 393-396 ISSN 0231-5882 R&D Projects: GA ČR GA15-13556S; GA MŠk 7AMB15FR015 Institutional support: RVO:61388963 Keywords : calcium channel * T-type channel * Ca(v)3.1 * immune cells Subject RIV: CE - Biochemistry Impact factor: 1.170, year: 2016

Design and suspension experiments of the full-size active magnetic bearing test rig for the HTR-10GT

International Nuclear Information System (INIS)

Lu Qiyue; Shi Lei; Zhao Lei; Yu Suyuan

2005-01-01

In this paper, we introduce the fundamental properties of the full-size active magnetic bearing experimental set system (AMB-F), including control unit, data I/O channel, feedback unit and executor. Besides, the 72-hours continuously running experiment of the AMB-F, with special attention to the vibration of stators' shell, is presented. This experiment is designed mainly for validating the total system's stability. It is the basis of further characteristic experiments. (authors)

Estudi de les unitats fraseológiques de la tercera esfera des d'una perspectiva diacrònica

Directory of Open Access Journals (Sweden)

Maria Àngels Fuster Ortuño

2014-03-01

que conformen la tercera esfera. Tractarem amb més profunditat la definició, l’origen i el tipus d’unitats que s’apleguen sota aquest terme. A continuació, analitzarem amb més aprofundiment un parell d’exemples representatius, com són una oronella no fa estiu i fer orelles sordes. Aquests exemples ens permetran observar les característiques generals del processos de fraseologització i canvi fraseològic.

Estudio sobre el software libre orientado a personas con discapacidad visual

OpenAIRE

Palomá Parra, Esaú

2015-01-01

Se pretende realizar un estudio sobre las herramientas TIC accesibles a las personas con discapacidad visual, que permita sugerir el diseño de un sistema universal accesible orientado a personas con discapacidad visual. Es pretén realitzar un estudi sobre les eines TIC accessibles a les persones amb discapacitat visual, que permeti suggerir el disseny d'un sistema universal accessible orientat a persones amb discapacitat visual. Master thesis for the Free Software program.

Proteomic analysis of changes in the protein composition of MCF-7 human breast cancer cells induced by all-trans retinoic acid, 9-cis retinoic acid, and their combination

Czech Academy of Sciences Publication Activity Database

Flodrová, Dana; Benkovská, Dagmar; Macejová, D.; Bialesova, L.; Hunakova, L.; Brtko, J.; Bobálová, Janette

2015-01-01

Roč. 232, č. 1 (2015), s. 226-232 ISSN 0378-4274 R&D Projects: GA MŠk(CZ) 7AMB12SK151 Institutional support: RVO:68081715 Keywords : retinoic acid * polyacrylamide gel electrophoresis * MALDI TOF MS Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 3.522, year: 2015

Modulation of cardiac connexin-43 by omega-3 fatty acid ethyl-ester supplementation demonstrated in spontaneously diabetic rats

Czech Academy of Sciences Publication Activity Database

Radošinská, J.; Kurahara, L. H.; Hiraishi, K.; Viczenczová, C.; Egan Beňová, T.; Szeiffová Bačová, B.; Dosenko, V.; Navarová, J.; Obšitník, B.; Imanaga, I.; Soukup, Tomáš; Tribulová, N.

2015-01-01

Roč. 64, č. 6 (2015), s. 795-806 ISSN 0862-8408 R&D Projects: GA MŠk(CZ) 7AMB14SK123 Institutional support: RVO:67985823 Keywords : diabetes * omega-3 fatty acids * cardiac connexin-43 * PKC * ultrastructure Subject RIV: ED - Physiology Impact factor: 1.643, year: 2015

Low-Cost Production of Composite Bushings for Jet Engine Applications

Science.gov (United States)

Gray, Robert A.

1998-01-01

The objectives of this research program were to reduce the manufacturing costs of variable stator vane bushings by 1) eliminating the expensive carbon fiber braiding operation, 2) replacing the batch mode impregnation, B-stage, and cutting operations with a continuous process, and 3) reducing the molding cycle and machining operations with injection molding to achieve near-net shapes. Braided bushings were successfully fabricated with both AMB-17XLD and AMB-TPD resin systems. The composite bushings achieved high glass transition temperature after post-cure (+300 C) and comparable weight loss to the PNM-15 bushings. ANM-17XLD bushings made with "batch-mode" molding compound (at 0.5 in. fiber length) achieved a +300 lb-force flange break strength which was superior to the continuous braided-fiber reinforced bushing. The non-MDA resin technology developed in this contract appears attractive for bushing applications that do not exceed a 300 C use temperature. Two thermoplastic polyimide resins were synthesized in order to generate injection molding compound powders. Excellent processing results were obtained at injection temperatures in excess of 300 C. Micro-tensile specimens were produced from each resin type and the Tg measurements (by TMA) for these samples were equivalent to AURUM(R). Thermal Gravimetric Analysis (TGA) conducted at 10 C/min showed that the non-MDA AMB-type polyimide thermoplastics had comparable weight loss to PMR-15 up to 500 C.

Thermal neutron capture cross-section and resonance integral measurements of {sup 139}La(n, γ){sup 140}La and {sup 140}Ce(n, γ){sup 141}Ce using a Am-Be neutron source

Energy Technology Data Exchange (ETDEWEB)

Panikkath, Priyada; Mohanakrishnan, P. [Manipal University, Manipal Centre for Natural Sciences, Karnataka (India)

2017-03-15

Thermal neutron capture cross-sections and resonance integrals of {sup 139}La(n, γ){sup 140}La and {sup 140}Ce (n, γ){sup 141}Ce are measured with respect to reference reactions {sup 197}Au(n, γ){sup 198}Au and {sup 55}Mn(n, γ){sup 56}Mn using the neutron activation technique. Measurements are carried out using neutrons from an Am-Be source located inside a concrete bunker. Two different methods are used for determining self-shielding factors of activation foils as well as for finding the epithermal neutron spectrum shape factor. For {sup 139}La with reference to {sup 197}Au and {sup 55}Mn the measured thermal cross sections are 9.24 ± 0.25 b and 9.28 ± 0.37 b, respectively, while the measured resonance integrals are 12.18 ± 0.67 b and 11.81 ± 0.94 b, respectively. For {sup 140}Ce with reference to {sup 197}Au and {sup 55}Mn the measured thermal cross sections are 0.44 ± 0.01 b and 0.44 ± 0.02 b, respectively, while the measured resonance integrals are 0.55 ± 0.03 b and 0.54 ± 0.04 b, respectively. The present measurements are compared with earlier measurements and evaluations. Presently estimated values confirm the established {sup 139}La(n, γ){sup 140}La cross-sections. The presently measured thermal capture cross-section {sup 140}Ce(n, γ){sup 141}Ce, though lower than the evaluated data, is having higher accuracy compared to previous measurements with large uncertainties. The resonance integral measured is higher (like most previous measurements) than most evaluations requiring a revision of the evaluated data. (orig.)

Study of the association degree between cerebral magnetic resonance signal and the transcranial sonography Estudio del grado de asociación entre la señal de resonancia magnética cerebral y la ecografía transcraneal Estudi del grau d'associació entre el senya de ressonancia magnètica cerebral i l'ecografia transcranial

OpenAIRE

Carrascosa Morales, Rafael

2012-01-01

El coregistre d'una imatge d'ecografia transcraneal amb un volum de ressonància magnètica cerebral i estudi del grau d'associació entre elles. Projecte el·laborat amb Transmural Biotech SL English: The study tries to achieve a multimodal registration between a transcranial sonography (TCS) and a cerebral magnetic resonance volume. After the registration stage, a statistical analysis of each brain matter (white matter, gray matter and cerebrospinal fluid) was performed to demonstrate the...

AFM study of advanced composite materials for organic photovoltaic cells with active layer based on P3HT:PCBM and chiral photosensitive liquid crystalline dopants

Czech Academy of Sciences Publication Activity Database

Iwan, A.; Sikora, A.; Hamplová, Věra; Bubnov, Alexej

2015-01-01

Roč. 42, č. 7 (2015), s. 964-972 ISSN 0267-8292 R&D Projects: GA MŠk 7AMB13PL041; GA ČR GA13-14133S; GA MŠk(CZ) LD14007; GA MŠk 7AMB13PL038 Grant - others:AVČR(CZ) M100101204 Institutional support: RVO:68378271 Keywords : AFM * chiral liquid crystal * organic solar cells * azo compounds * photovoltaic s Subject RIV: JJ - Other Materials Impact factor: 2.244, year: 2015

Stability of Durum Wheat Genotypes in Some Agronomic Traits Under Bursa Ecological Conditions

Directory of Open Access Journals (Sweden)

Esra Aydoğan Çiftçi

2017-11-01

Full Text Available In the study it is aimed to determine the stabilities of some agronomic traits of 10 different durum wheats over the years in conditions of Bursa. Research was carried out in randomized complete block design with three replications between the years of 2008-2013. Averages of genotypes of agronomic characteristics, Eberhart and Russell’s regression coefficient and deviation from regression, Francis and Kannenberg’s coefficient of variation and environmental variance used as stability parameters. When the results of the study evaluated at the stability analysis, Amb × Çak-30 lines were determined to be stable in most of the agronomic traits. As for grain yield, which is of great importance for the producer, breeding lines of Amb × Çak -26 and Amb × Çak-30 were determined in good harmony at Bursa under different climatic conditions over five years.

Neutron activation analysis: Modelling studies to improve the neutron flux of Americium–Beryllium source

Directory of Open Access Journals (Sweden)

Abdessamad Didi

2017-06-01

Full Text Available Americium–beryllium (Am-Be; n, γ is a neutron emitting source used in various research fields such as chemistry, physics, geology, archaeology, medicine, and environmental monitoring, as well as in the forensic sciences. It is a mobile source of neutron activity (20 Ci, yielding a small thermal neutron flux that is water moderated. The aim of this study is to develop a model to increase the neutron thermal flux of a source such as Am-Be. This study achieved multiple advantageous results: primarily, it will help us perform neutron activation analysis. Next, it will give us the opportunity to produce radio-elements with short half-lives. Am-Be single and multisource (5 sources experiments were performed within an irradiation facility with a paraffin moderator. The resulting models mainly increase the thermal neutron flux compared to the traditional method with water moderator.

Control of Surge in Centrifugal Compressors by Active Magnetic Bearings Theory and Implementation

CERN Document Server

Yoon, Se Young; Allaire, Paul E

2013-01-01

Control of Surge in Centrifugal Compressors by Active Magnetic Bearings sets out the fundamentals of integrating the active magnetic bearing (AMB) rotor suspension technology in compressor systems, and describes how this relatively new bearing technology can be employed in the active control of compressor surge. The authors provide a self-contained and comprehensive review of rotordynamics and the fundamentals of the AMB technology. The active stabilization of compressor surge employing AMBs in a machine is fully explored, from the modeling of the instability and the design of feedback controllers, to the implementation and experimental testing of the control algorithms in a specially-constructed, industrial-size centrifugal compression system. The results of these tests demonstrate the great potential of the new surge control method developed in this text. This book will be useful for engineers in industries that involve turbocompressors and magnetic bearings, as well as for researchers and graduate students...

Influence of the Alkyl Side Chain Length on the Thermophysical Properties of Chiral Ionic Liquids with a (1R,2S,5R)-(–)-Menthol Substituent and Data Treatment by Means of Mathematical Gnostics.

Czech Academy of Sciences Publication Activity Database

Andresová, Adéla; Bendová, Magdalena; Schwarz, Jaroslav; Wagner, Zdeněk; Feder-Kubis, J.

2017-01-01

Roč. 242, SEP 2017 (2017), s. 336-348 ISSN 0167-7322 R&D Projects: GA MŠk(CZ) 7AMB14PL005 Grant - others:NSC(PL) 2011/01/B/ST5/06659 Institutional support: RVO:67985858 Keywords : chiral ionic liquids * thermophysical properties * mathematical gnostics Subject RIV: CF - Physical ; Theoretical Chemistry OBOR OECD: Physical chemistry Impact factor: 3.648, year: 2016

Pseudospectra in non-Hermitian quantum mechanics

Czech Academy of Sciences Publication Activity Database

Krejčiřík, David; Siegl, Petr; Tater, Miloš; Viola, J.

2015-01-01

Roč. 56, č. 10 (2015), s. 103513 ISSN 0022-2488 R&D Projects: GA ČR(CZ) GA14-06818S; GA MŠk 7AMB12FR020 Institutional support: RVO:61389005 Keywords : quadratic differential operators * magnetic field Subject RIV: BE - Theoretical Physics Impact factor: 1.234, year: 2015

Molecular Dynamics Simulations of a Cyclic DP-240 Amylose Fragment in a Periodic Cell: Glass Transition Temperature and Water Diffusion

Science.gov (United States)

Molecular dynamics simulations using AMB06C, an in-house carbohydrate force field, (NPT ensembles, 1atm) were carried out on a periodic cell that contained a cyclic-DP-240 amylose fragment and TIP3P water molecules. Molecular conformation and movement of the amylose fragment and water molecules at ...

Lactic acid derivatives with three-phenyl ring molecular core: design and mesomorphic properties

Czech Academy of Sciences Publication Activity Database

Hamplová, Věra; Novotná, Vladimíra; Kašpar, Miroslav

2014-01-01

Roč. 468, č. 1 (2014), s. 18-27 ISSN 0015-0193 R&D Projects: GA ČR GA13-14133S; GA MŠk 7AMB13PL038 Institutional support: RVO:68378271 Keywords : liquid crystals * smectic phases * ferroelectricity Subject RIV: JJ - Other Materials Impact factor: 0.469, year: 2014

The growth of zinc phthalocyanine thin films by pulsed laser deposition

Czech Academy of Sciences Publication Activity Database

Novotný, Michal; Šebera, Jakub; Bensalah-Ledoux, A.; Guy, S.; Bulíř, Jiří; Fitl, Přemysl; Vlček, Jan; Zákutná, D.; Marešová, Eva; Hubík, Pavel; Kratochvílová, Irena; Vrňata, M.; Lančok, Ján

2016-01-01

Roč. 31, č. 1 (2016), s. 163-172 ISSN 0884-2914 R&D Projects: GA MŠk(CZ) LM2011029; GA ČR(CZ) GA14-10279S; GA MŠk(CZ) 7AMB14FR010 Institutional support: RVO:68378271 Keywords : organometallic * film * laser ablation Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.673, year: 2016

Transpermeance Amplifier Applied to Magnetic Bearings

Directory of Open Access Journals (Sweden)

Jossana Ferreira

2017-02-01

Full Text Available The most conventional approach of controlling magnetic forces in active magnetic bearings (AMBs is through current feedback amplifiers: transconductance. This enables the operation of the AMB to be understood in terms of a relatively simple current-based model as has been widely reported on in the literature. The alternative notion of using transpermeance amplifiers, which approximate the feedback of gap flux rather than current, has been in commercial use in some form for at least thirty years, however is only recently seeing more widespread acceptance as a commercial standard. This study explores how such alternative amplifiers should be modeled and then examines the differences in behavior between AMBs equipped with transconductance and transpermeance amplifiers. The focus of this study is on two aspects. The first is the influence of rotor displacement on AMB force, commonly modeled as a constant negative equivalent mechanical stiffness, and it is shown that either scheme actually leads to a finite bandwidth effect, but that this bandwidth is much lower when transpermeance is employed. The second aspect is the influence of eddy currents. Using a very simple model of eddy currents (a secondary short-circuited coil, it is demonstrated that transpermeance amplifiers can recover significant actuator bandwidth compared with transconductance, but at the cost of needing increased peak current headroom.

An identification method of orbit responses rooting in vibration analysis of rotor during touchdowns of active magnetic bearings

Science.gov (United States)

Liu, Tao; Lyu, Mindong; Wang, Zixi; Yan, Shaoze

2018-02-01

Identification of orbit responses can make the active protection operation more easily realize for active magnetic bearings (AMB) in case of touchdowns. This paper presents an identification method of the orbit responses rooting on signal processing of rotor displacements during touchdowns. The recognition method consists of two major steps. Firstly, the combined rub and bouncing is distinguished from the other orbit responses by the mathematical expectation of axis displacements of the rotor. Because when the combined rub and bouncing occurs, the rotor of AMB will not be always close to the touchdown bearings (TDB). Secondly, we recognize the pendulum vibration and the full rub by the Fourier spectrum of displacement in horizontal direction, as the frequency characteristics of the two responses are different. The principle of the whole identification algorithm is illustrated by two sets of signal generated by a dynamic model of the specific rotor-TDB system. The universality of the method is validated by other four sets of signal. Besides, the adaptability of noise is also tested by adding white noises with different strengths, and the result is promising. As the mathematical expectation and Discrete Fourier transform are major calculations of the algorithm, the calculation quantity of the algorithm is low, so it is fast, easily realized and embedded in the AMB controller, which has an important engineering value for the protection of AMBs during touchdowns.

Understanding Drug Release Data through Thermodynamic Analysis

Directory of Open Access Journals (Sweden)

Marjorie Caroline Liberato Cavalcanti Freire

2017-06-01

Full Text Available Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively. Release profiles from the DDSs were performed, and the mathematical modeling of the data was carried out. Activation energy, enthalpy, entropy and Gibbs free energy of the drug release process were determined. AmB release profiles showed that the relationship to overcome the enthalpic barrier was PVA-fiber > PVA-film > PLA-fiber > PLA-film. Drug release kinetics from the fibers and the films were better fitted on the Peppas–Sahlin and Higuchi models, respectively. The thermodynamic parameters corroborate these findings, revealing that the AmB release from the evaluated systems was an endothermic and non-spontaneous process. Thermodynamic parameters can be used to explain the drug kinetic release profiles. Such an approach is of utmost importance for DDS containing insoluble compounds, such as AmB, which is associated with an erratic bioavailability.

Oral Candida in Patients with Fixed Orthodontic Appliance: In Vitro Combination Therapy.

Science.gov (United States)

Alhamadi, Wisam; Al-Saigh, Rafal J; Al-Dabagh, Nebras N; Al-Humadi, Hussam W

2017-01-01

Fixed orthodontic appliance (FOA) increases the cariogenic microorganisms of mouth including candida. The aim was to evaluate the pharmacodynamic effects of some antibacterial drugs in combination with most applicable antifungal agents on candida isolated from patients with FOA. Three antifungal agents (amphotericin B (AMB), ketoconazole (KET), and itraconazole (ITZ)) and three antibacterial drugs (ciprofloxacin (CIP), doxycycline (DOX), and metronidazole (MET)) with serial concentrations have been used and microdilution broth method has been done for single and combination therapy, then fungal growth was assessed spectrophotometrically, and the combinations were evaluated by bliss independent analysis. According to bliss independent interaction, the synergistic interactions depended on Δ E values that showed the best for CIP was with AMB (Δ E = 55.14) followed with KET (Δ E = 41.23) and lastly ITR (Δ E = 39.67) at CIP = 150 mg/L. DOX was optimal with KET (Δ E = 42.11) followed with AMB (Δ E = 40.77) and the lowest with ITR (Δ E = 9.12) at DOX = 75 mg/L. MET is the best with AMB (Δ E = 40.95) and then with ITR (Δ E = 35.45) and finally KET (Δ E = 15.15) at MET 200 mg/L. Moreover, usage of higher concentrations of antibacterial agents revealed inhibitory effects. This study uncovers the optimum antibiotic combination therapy against cariogenic candida with FOA by usage of low therapeutic concentrations.

Insuficiència cardíaca i fallida renal : quan tot s'ajunta

OpenAIRE

Zamora, Elisabet

2008-01-01

Un dels problemes que coexisteixen amb la insuficiència cardíaca és la insuficiència renal. Els autors d'aquest article proposen un mètode alternatiu per poder detectar de manera més precisa la presència d'aquesta fallida renal en els pacients amb insuficiència cardíaca, ja que els mètodes habituals, basats únicament en la determinació de la creatinina en sang, són menys sensibles.

Study regarding magnetospirillum griphyswaldenses bacteria biochemical changes using FTIR and Raman spectroscopy

International Nuclear Information System (INIS)

Mihai, C.; Institute of Biology, Bucharest; Mihaela, M.; Ioan, A.; Ovidius University, Constanta

2011-01-01

Complete text of publication follows. Spectroscopy using Fourier transform and Raman spectroscopy can be used to enlighten functional groups that belong to different biomolecules that are specific to cells (proteins, lipids, carbohydrates, nucleic acids), thus obtaining valuable information regarding bacteria's biochemical composition. Since microorganisms react very promptly to the culture medium changes, the apparition of a stress agent produces a modification of the cellular enzymatic print in order to compensate for the effect of those factors, thus the bacteria self adapting to those changes. These methods can be used to highlight the metabolically modifications in cells which respond to stress factors. The biochemical modification are important in bioremediation processes like biosorption of metal contaminated waste water from metallurgical baths or even from irradiator pool, heavy water from nuclear power plant. The main targets are to analyze the biochemical modification appeared in presence or absence of two metals, Fe and Co. The presence of Fe is benefit for bacteria because she can absorb iron and deposit as magnetic inside the cell. The presence of Co determines changes in metabolism with the loss of many polar bindings but the growth was not inhibited even in concentration like 100 mM.

On the Use of the Field Sunset Semi-continuous Analyzer to Measure Equivalent Black Carbon Concentrations.

Czech Academy of Sciences Publication Activity Database

Zíková, Naděžda; Vodička, Petr; Ludwig, W.; Hitzenberger, R.; Schwarz, Jaroslav

2016-01-01

Roč. 50, č. 3 (2016), s. 284-296 ISSN 0278-6826 R&D Projects: GA ČR(CZ) GBP503/12/G147; GA MŠk 7AMB12AT021 Institutional support: RVO:67985858 Keywords : black carbon * aerosols * aethalometer Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.926, year: 2016

In silico prediction of ErbB signal activation from receptor expression ...

Indian Academy of Sciences (India)

85

Annals of biomedical engineering 35 1012-1025. Machado D, Costa RS, Rocha M, Ferreira EC, Tidor B, Rocha I 2011 Modeling formalisms in Systems Biology. AMB Express 1 45. McCabe Pryor M, et al. 2015 Orchestration of ErbB3 signaling through heterointeractions and homointeractions. Mol Biol Cell 26 4109-4123.

Three Peaks of 2011 Draconid Activity Including that Connected with Pre-1900 Material

Czech Academy of Sciences Publication Activity Database

Koten, Pavel; Vaubaillon, J.; Tóth, J.; Margonis, A.; Ďuriš, F.

2014-01-01

Roč. 112, 1-4 (2014), s. 15-31 ISSN 0167-9295 R&D Projects: GA ČR GA205/09/1302; GA MŠk 7AMB13FR006 Institutional support: RVO:67985815 Keywords : meteors * meteor showers * Draconids Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 0.667, year: 2014

Amphotericin B: an antifungal drug in nanoformulations for the treatment of paracoccidioidomycosis

Directory of Open Access Journals (Sweden)

Mônica Pereira Garcia

2013-12-01

Full Text Available The use of magnetic nanoparticles (MNPs in drug delivery vehicles must address issues such as drugloading capacity, desired release profile, aqueous dispersion stability, biocompatibility with cells and tissue, and retention of magnetic properties after interaction with macromolecules or modification via chemical reactions. Amphotericin B (AmB is still the first choice for the treatment of severe paracoccidioidomycosis, an important systemic fungal infection caused by Paracoccidoides brasiliensis. Unfortunately, AmB causes acute side effects (mainly urinary problems following intravenous administration, which limits its clinical use. The use of magnetic nanoparticles stabilized with biocompatible substances, together with the possibility of their conjugation with drugs has become a new nanotechnological strategy in the treatment of diseases for drug delivery to specific locations, such as the lungs in paracoccidoidiodomycosis. This review provides an overview of the disease, its etiologic agent and treatment with emphasis on the main strategies to improve the use of AmB in nanoformulations.

The effect of baryons in the cosmological lensing PDFs

Science.gov (United States)

Castro, Tiago; Quartin, Miguel; Giocoli, Carlo; Borgani, Stefano; Dolag, Klaus

2018-05-01

Observational cosmology is passing through a unique moment of grandeur with the amount of quality data growing fast. However, in order to better take advantage of this moment, data analysis tools have to keep up the pace. Understanding the effect of baryonic matter on the large-scale structure is one of the challenges to be faced in cosmology. In this work, we have thoroughly studied the effect of baryonic physics on different lensing statistics. Making use of the Magneticum Pathfinder suite of simulations we show that the influence of luminous matter on the 1-point lensing statistics of point sources is significant, enhancing the probability of magnified objects with μ > 3 by a factor of 2 and the occurrence of multiple-images by a factor 5 - 500 depending on the source redshift and size. We also discuss the dependence of the lensing statistics on the angular resolution of sources. Our results and methodology were carefully tested in order to guarantee that our uncertainties are much smaller than the effects here presented.

Projection Mapping amb Shadertoy i openFrameworks

OpenAIRE

Borràs Massaguer, Lluís

2015-01-01

El projection mapping és un món molt complex, cada projecció explica una història diferent i hi ha molts perfils de persona treballant-hi al darrera, des del dissenyador gràfic, passant pels tècnics de vídeo i so fins a l’autor de la història. Les aplicacions que s’utilitzen per fer projection mapping, de les quals les més conegudes: ’Resolume Arena’, ’Mad Mapper’ i ’arkaos GrandVJ XT’ són aplicacions comercials a gran escala. És un tipus de software molt específic i, per tant, ...

Pàgina web amb gestor de continguts

OpenAIRE

Castells Gonzalbo, Pau

2014-01-01

En aquest informe es detalla l'anàlisi previ i posterior a la implementació del projecte, que consta del disseny i implementació d'una eina per gestionar el contingut d'una pàgina web, concretament una web orientada a músics. En este informe se detalla el análisis previo y posterior a la implementación del proyecto, que consta del diseño e implementación de una herramienta para gestionar el contenido de una página web, concretamente una web orientada a músicos.

2530-IJBCS-Article-Alain S A Ambe

African Journals Online (AJOL)

hp

2015 International Formulae Group. All rights ... Mots clés: Mode de préparation, Candida albicans, cytotoxicité, Cellules HFF ; Enantia polycarpa. ... marché et utilisées en thérapeutique ont perdu ...... Manque d'Accès aux Médicaments.

2530-IJBCS-Article-Alain S A Ambe

African Journals Online (AJOL)

hp

vitro sur des cellules HFF a mis en évidence des effets cytotoxiques de la plante sur les cellules humaines à des ... compte le coût élevé des médicaments ..... solubilisés dans du diméthylsulfoxyde. (DMSO) 10 mM puis l'absorbance ou la densité optique (DO) a été mesuré. La mesure de la densité optique (DO) de chaque ...

Algunos aspectos sobre blockchains y smart contracts en educación superior

OpenAIRE

Amorós Poveda, Lucía

2018-01-01

Els conceptes de cadenes de blocs (blockchains) i contractes intel·ligents (smart contracts) ofereixen una alternativa sostenible en educació superior. Des d’aquest objectiu, es presenta una revisió d’ambdós conceptes i la seva relació amb els termes bitcoin, ledger, edublock i educoin. En un segon moment, s’atén a les xarxes en educació superior basades en tecnologia de cadenes de blocs, el seu vincle amb els contractes intel·ligents i les possibilitats a dia d’avui.

Cruise speed reduction for air traffic flow management

OpenAIRE

Delgado Muñoz, Luis

2013-01-01

Avui dia un considerable nombre d’infraestructures del transport aeri tenen problemes de congestió. Aquesta situació es veu empitjorada amb l’increment de trànsit existent i amb la seva densitat deguda al sistema de hub i spoke utilitzat per les companyies aèries. Aquesta congestió es veu agreujada puntualment per disminucions de capacitat per causes com la meteorologia. Per mitigar aquests desequilibris, normalment són implementades mesures de gestió del flux de transit aeri (ATFM), sent el ...

Efectivitat de la fisioteràpia en la paràlisi cerebral infantil espàstica.

OpenAIRE

Tella Aldomà, Àurea

2015-01-01

Pregunta de revisió: Quina intervenció terapèutica de fisioteràpia: vibroteràpia, hidroteràpia, hipoteràpia, estiraments, Bobath o electroteràpia, és més efectiva en pacients amb Paràlisi Cerebral Infantil (PCI) espàstica? Objectiu: Revisar i comparar l’efectivitat dels diferents tractaments de fisioteràpia actuals per tractar la espasticitat en nens amb PCI. Metodologia: S’han utilitzat bases de dades com Scopus, Pubmed, PEDro, Journal of Orthopaedic & Sports Physical Thera...

Noves dades sobre el mecanisme neural de la consolidació de la memòria: una oportunitat per a atenuar l’impacte emocional de les experiències traumàtiques

OpenAIRE

Lanuza, Enrique

2016-01-01

Durant la major part del segle xx, els estudis científics sobre la memòria assumien que les memòries eren immutables una vegada es consolidaven, tot i que podien perdre qualitat amb el pas del temps. Dades recents han revelat que les memòries, tot i estar ja consolidades, es tornen làbils durant la seua rememoració. Aquest descobriment implica que poden ser modificades i per tant emmagatzemades de nou amb aquestes modificacions. Aquestes investigacions obrin noves possibilitats...

Les Variacions Goldberg

OpenAIRE

Gallén Muñoz, Andreu

2011-01-01

L’Ària amb diverses variacions BWV 988, quarta part dels Clavier-übung, de Johann Sebastian Bach, és una obra que ha estat objecte de molts estudis. La seva extrema bellesa, el sobrenom amb què avui la coneixem, Variacions Goldberg -a partir de la llegenda que explica Forkel sobre un comte que patia insomni i el seu clavecinista Goldberg- i la seva estructura interna tan perfectament calculada, alhora que generadora de grans preguntes complexes de respondre, fan d’aquesta obra un mite indiscu...

Boron nitride nanosheets reinforced glass matrix composites

Czech Academy of Sciences Publication Activity Database

Saggar, Richa; Porwal, H.; Tatarko, P.; Dlouhý, Ivo; Reece, M. J.

2015-01-01

Roč. 114, SEP (2015), S26-S32 ISSN 1743-6753 R&D Projects: GA MŠk(CZ) 7AMB14SK155 EU Projects: European Commission(XE) 264526 Institutional support: RVO:68081723 Keywords : Boron nitride nanosheets * Borosilicate glass * Mechanical properties Subject RIV: JL - Materials Fatigue, Friction Mechanics Impact factor: 1.162, year: 2015

Inhomogeneous molecular ring around the B[e] supergiant LHA 120-S 73

Czech Academy of Sciences Publication Activity Database

Kraus, Michaela; Cidale, L.S.; Arias, M.L.; Maravelias, Grigorios; Nickeler, Dieter Horst; Torres, A.F.; Borges Fernandes, M.; Aret, A.; Curé, M.; Vallverdú, R.; Barbá, R.H.

2016-01-01

Roč. 593, September (2016), s. 1-14 ISSN 0004-6361 R&D Projects: GA ČR(CZ) GA14-21373S; GA MŠk(CZ) 7AMB14AR017 Institutional support: RVO:67985815 Keywords : circumstellar matter * early-type stars * supergiants Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.378, year: 2014

Schrodinger operators with delta-interactions supported on conical surfaces

Czech Academy of Sciences Publication Activity Database

Behrndt, J.; Exner, Pavel; Lotoreichik, V.

2014-01-01

Roč. 47, č. 35 (2014), s. 355202 ISSN 1751-8113 R&D Projects: GA ČR(CZ) GA14-06818S; GA MŠk 7AMB13AT010 Institutional support: RVO:61389005 Keywords : Schrödinger operator * delta potential * infinite discrete spectrum Subject RIV: BE - Theoretical Physics Impact factor: 1.583, year: 2014

An alternative method for the measurement of neutron flux

Indian Academy of Sciences (India)

dose rate. We have used a 241AmBe neutron source for neutron irradiation, and the neutron dose rate and count rate were ... neutron sources, e.g., for the characterization of superheated droplet detectors (SDD). [1–6]. The SDD is a .... Grants Commission (UGC) for the financial assistance provided for this work. References.

Mayflies of the Caucasus Mountains. II. Description of the first representative of the subgenus Helvetoraeticus Bauernfeind & Soldán, 2012 (Heptageniidae: Ecdyonurus)

Czech Academy of Sciences Publication Activity Database

Kluge, N. J.; Godunko, Roman J.; Apanaskevich, D. A.

2013-01-01

Roč. 3608, č. 1 (2013), s. 51-66 ISSN 1175-5326 R&D Projects: GA ČR GA206/08/1389 Grant - others:Ministerstvo školství(CZ) MOBILITY 7AMB12SK144 Institutional support: RVO:60077344 Keywords : Ephemeroptera * new species * Georgia Subject RIV: EG - Zoology Impact factor: 1.060, year: 2013 http://www.mapress.com/zootaxa/2013/f/z03608p066f.pdf

Dítě ve velkomoravských právních památkách

Czech Academy of Sciences Publication Activity Database

Havlíková, Lubomíra

2012-01-01

Roč. 5, č. 1 (2012), s. 1-10 ISSN 1337-8740 R&D Projects: GA MŠk 7AMB12SK161 Institutional support: RVO:68378017 Keywords : history * gender studies * Great Moravian law * Slavonic law * Byzantine law * child * woman * matrimony * Great Moravia * Constanrtine and Methodius Subject RIV: AB - History http://www.ukm.ff.ukf.sk/wp-content/uploads/2012/09/konstantinove-listy-2012text.pdf

Functional diversity of staphylinid beetles (Coleoptera: Staphylinidae) in maize fields: testing the possible effect of genetically modified, insect resistant maize

Czech Academy of Sciences Publication Activity Database

Svobodová, Zdeňka; Skoková Habuštová, Oxana; Boháč, J.; Sehnal, František

2016-01-01

Roč. 106, č. 4 (2016), s. 432-445 ISSN 0007-4853 R&D Projects: GA MZe QH91093 Grant - others:GA JU(CZ) 038/2014/P; project MOBILITY(CZ) 7AMB14SK096 Program:7A Institutional support: RVO:60077344 Keywords : GM crops * Bt maize * Cry3Bb1 Subject RIV: GF - Plant Pathology, Vermin, Weed, Plant Protection Impact factor: 1.758, year: 2016

The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca2+ currents by altering calnexin-dependent trafficking of Ca(v)3.2 channels

Czech Academy of Sciences Publication Activity Database

Proft, Juliane; Rzhepetskyy, Yuriy; Lazniewska, Joanna; Zhang, F. X.; Cain, S. M.; Snutch, T. P.; Zamponi, G. W.; Weiss, Norbert

2017-01-01

Roč. 7, Sep 14 (2017), č. článku 11513. ISSN 2045-2322 R&D Projects: GA ČR GA15-13556S; GA MŠk 7AMB15FR015 Institutional support: RVO:61388963 Keywords : asparagine-linked glycosylation * idiopathic generalized epilepsies * voltage-activated currents Subject RIV: ED - Physiology OBOR OECD: Physiology (including cytology) Impact factor: 4.259, year: 2016 https://www.nature.com/articles/s41598-017-11591-5

Single-sphere multiple-detector neutron spectrometer. Final report on Phase 1

International Nuclear Information System (INIS)

Sinclair, F.; Stern, I.; Hahn, R.W.; Entine, G.

1987-07-01

To address the problem of accurate, timely estimates of the neutron spectral flux, researchers are developing a monitoring instrument based on a single moderating sphere with a large number of independent sensors. Such a single-sphere spectrometer would allow easy measurement of quality factors. This is made possible by the recent development of a novel digital sensor which detects radiation induced errors in a dynamic random-access memory. During Phase I of the SBIR program, researchers constructed a first prototype of the single-sphere spectrometer, measured its response in a neutron flux from an isotopic Am-Be source in several geometries, and compared these with the results of Monte Carlo simulations of neutron transport. The preliminary results show that the approach is feasible and relatively straightforward

Una tercera via...digital: noves tecnologies i creativitat a la Xina contemporània

Directory of Open Access Journals (Sweden)

Xavier Ortells Nicolau

2011-05-01

Full Text Available La reforma econòmica i social de la Xina, iniciada a principi dels anys vuitanta, ha coincidit amb una revolució global en la creació i la difusió de continguts. A més de contribuir a la seva obertura a l'exterior i al seu espectacular creixement econòmic, a la Xina les noves tecnologies han ofert innovadores possibilitats per a negociar un context social i polític altament sensible, caracteritzat per restriccions en els continguts i les plataformes d'expressió. Tant els nous mitjans i formats de comunicació (blogs, xats, fòrums com les tecnologies digitals de creació d'imatges (3-D, realitat virtual, realitat augmentada han aportat flexibilitat i han esperonat usuaris, artistes i investigadors a trobar noves i creatives formes d'interacció amb la societat. L'article destaca la incidència d'aquestes noves plataformes i tecnologies amb relació amb dos aspectes: d'una banda, l'adequació de l'horitzontalitat i la flexibilitat de les TIC a la rapidesa dels processos de transformació social i política a la Xina contemporània, i d'altra banda, les condicions i oportunitats per a la negociació social de la història generades pel nacionalisme governamental, ocupat en un intens procés de revisionisme de l'època tardoimperial.

«Temeritats enlluernadores»: La ciutat en la poesia de Bartomeu Rosselló-Pòrcel

Directory of Open Access Journals (Sweden)

Enric Bou

2015-12-01

Full Text Available La poesia de Rosselló-Pòrcel és una obra de dimensió limitada, però d’una gran diversitat. En els últims anys s’ha estudiat amb precisió la presència d’un llegat postsimbolista. En aquest article s’analitza un aspecte menystingut: el sentit de la presència de mons urbans en la poesia de Rosselló-Pòrcel. El poeta experimenta amb un nou concepte de la metàfora i incorpora els elements que componen l’escenari urbà nomenats amb ajuda d’un lèxic despullat del tabú del prosaisme. L’adjectivació, a més, farà possible unir l’experiència del que és descriptiu amb la desrealització de l’objecte contemplat. L’anàlisi detinguda de tres poemes complementa la reflexió. Rosselló-Pòrcel’s poetry is a work of limited extension, but of great diversity. In recent years critics have studied with precision the presence of a post-symbolist legacy. In this article I take a look at an undervalued aspect of it: the meaning and uses of urban worlds in his poetry. The poet experimented with a new concept of metaphor and incorporates elements from the urban scene using a lexicon that includes prosaic elements. Adjectives make possible the combination of description with object contemplation. The thorough analysis of three poems completes the reevaluation.

Antifungal activity of oral (Tragacanth/acrylic acid) Amphotericin B carrier for systemic candidiasis: in vitro and in vivo study.

Science.gov (United States)

Mohamed, Heba A; Radwan, Rasha R; Raafat, Amany I; Ali, Amr El-Hag

2018-02-01

In an effort to increase the oral bioavailability of Amphotericin B (AmB), a pH-sensitive drug carrier composed of Tragacanth (Trag) and acrylic acid (AAc) was prepared using γ-irradiation. The swelling behavior of (Trag/AAc) hydrogels was characterized as a function of pH and ionic strength of the swelling medium. The obtained swelling indices revealed the ability of the prepared hydrogel to protect a loaded drug in stomach-simulated medium (Fickian behavior) and to release such drug in intestinal-simulated medium (non-Fickian behavior). In vitro release studies of the antifungal (AmB) were performed to evaluate the hydrogel potential as a drug carrier. The antifungal activity of the prepared oral formulation was investigated in a mouse model of systemic candidiasis. Data revealed that (Trag/AAc)-AmB has a potent antifungal efficacy as demonstrated by prolonging the survival time and reducing the tissue fungal burden, serum antibody titers, as well as inflammatory cytokines in kidney and liver tissues. Furthermore, in vivo toxicity of (Trag/AAc)-AmB was assessed via measuring kidney and liver functions, and results displayed the safety of this novel AmB formulation which was confirmed by histopathological examination. Overall, results indicated that the prepared (Trag/AAc)-AmB is an effective oral delivery system for AmB with better bioavailability and minimal toxicity and could represent a promising approach for improving the therapeutic index of the drug.

Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats

Czech Academy of Sciences Publication Activity Database

Špolcová, Andrea; Mikulášková, Barbora; Kršková, K.; Gajdošechová, L.; Zórad, Š.; Olszanecki, R.; Suski, M.; Bujak-Gizycka, B.; Železná, Blanka; Maletínská, Lenka

2014-01-01

Roč. 15, Sep 25 (2014), 111/1-111/8 ISSN 1471-2202 R&D Projects: GA ČR GAP303/12/0576; GA MŠk 7AMB12FR011 Institutional support: RVO:61388963 Keywords : Zucker fa/fa rats * insulin resistance * obesity * GSK-3 beta * Tau protein Subject RIV: CE - Biochemistry Impact factor: 2.665, year: 2014

Formaldehyde fixation is detrimental to actin cables in glucose-depleted S. cerevisiae cells

Czech Academy of Sciences Publication Activity Database

Vašicová, Pavla; Rinnerthaler, M.; Hašková, Danuša; Nováková, Lenka; Malcová, Ivana; Breitenbach, M.; Hašek, Jiří

2016-01-01

Roč. 3, č. 5 (2016), s. 206-214 E-ISSN 2311-2638 R&D Projects: GA ČR GAP305/12/0480; GA ČR(CZ) GA16-05497S; GA MŠk(CZ) 7AMB16AT006 Institutional support: RVO:61388971 Keywords : Abp140-GFP * Abp1-RFP * Actin cables Subject RIV: EE - Microbiology, Virology

Essential spectrum of Schrödinger operators with delta-interactions on the union of compact Lipschitz hypersurfaces

Czech Academy of Sciences Publication Activity Database

Behrndt, J.; Exner, Pavel; Lotoreichik, V.

2013-01-01

Roč. 13, č. 1 (2013), s. 523-524 ISSN 1617-7061. [84th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM). 18.3.2013-22.3.2013, Novi Sad ] R&D Projects: GA MŠk 7AMB13AT010 Institutional support: RVO:61389005 Keywords : Schrodinger operators * delta interactioan Subject RIV: BE - Theoretical Physics

Author Details

African Journals Online (AJOL)

Mangu, AMB. Vol 38, No 1&2 (2013) - Articles US Foreign Policy under President Barack Obama and the Promotion of Multilateralism and the Rule of Law Abstract PDF. ISSN: 0850-3907. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

Probing the localization of charge and the extent of disorder through electronic transport on Au nanoparticle–copper phthalocyanine multijunction networks

Czech Academy of Sciences Publication Activity Database

Balliou, A.; Kazim, Samrana; Pfleger, Jiří; Rakušan, J.; Skoulatakis, G.; Kennou, S.; Glezos, N.

2016-01-01

Roč. 253, č. 5 (2016), s. 1009-1019 ISSN 0370-1972 R&D Projects: GA MŠk(CZ) 7AMB12GR022; GA ČR(CZ) GAP108/12/1143 Institutional support: RVO:61389013 Keywords : Au nanoparticles * carrier localization * electrical transport Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 1.674, year: 2016

Double station observation of Draconid meteor outburst from two moving aircraft

Czech Academy of Sciences Publication Activity Database

Koten, Pavel; Vaubaillon, J.; Margonis, A.; Toth, J.; Ďuriš, F.; McAulliffe, J.; Oberst, J.

2015-01-01

Roč. 118, December (2015), s. 112-119 ISSN 0032-0633 R&D Projects: GA ČR GA14-25251S; GA ČR(CZ) GAP209/11/1382; GA MŠk 7AMB13FR006 Institutional support: RVO:67985815 Keywords : meteors * meteor showers * Draconids Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 1.942, year: 2015

Investigation of electrical and optical properties of Ge-Ga-As-S glasses doped with rare-earth ions

Czech Academy of Sciences Publication Activity Database

Zavadil, Jiří; Kubliha, M.; Kostka, Petr; Iovu, M.; Labaš, V.; Ivanova, Z.G.

-, č. 377 (2013), s. 85-89 ISSN 0022-3093 R&D Projects: GA ČR GAP106/12/2384; GA MŠk 7AMB12SK147 Institutional support: RVO:67985882 ; RVO:67985891 Keywords : Chalcogenide glass * Direct electrical conductivity * Photoluminescence Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering; DB - Geology ; Mineralogy (USMH-B) Impact factor: 1.716, year: 2013

Probing the ejecta of evolved massive stars in transition A VLT/SINFONI K-band survey

Czech Academy of Sciences Publication Activity Database

Oksala, Mary E.; Kraus, Michaela; Cidale, L.S.; Muratore, M.F.; Borges Fernandes, M.

2013-01-01

Roč. 558, October (2013), A17/1-A17/20 ISSN 0004-6361 R&D Projects: GA ČR(CZ) GAP209/11/1198; GA MŠk 7AMB12AR021 Institutional support: RVO:67985815 Keywords : infrared stars * spectroscopic techniques * massive stars Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.479, year: 2013

Species assemblages of ladybirds including the harlequin ladybird Harmonia axyridis: a comparison at large spatial scale in urban habitats

Czech Academy of Sciences Publication Activity Database

Viglášová, S.; Nedvěd, Oldřich; Zach, P.; Kulfan, J.; Parák, M.; Honěk, A.; Martinková, Z.; Roy, H. E.

2017-01-01

Roč. 62, č. 3 (2017), s. 409-421 ISSN 1386-6141 R&D Projects: GA MŠk(CZ) 7AMB14SK016 Institutional support: RVO:60077344 Keywords : Aphids * Coleoptera * community Subject RIV: EH - Ecology, Behaviour OBOR OECD: Ecology Impact factor: 1.918, year: 2016 https://link.springer.com/article/10.1007/s10526-017-9793-0

L'escriptura i el llibre a la Catalunya Central als segles XIII i XIV

OpenAIRE

Torras i Cortina, Miquel

2004-01-01

Consultable des del TDX Títol obtingut de la portada digitalitzada Aquesta investigació reconstrueix la vida cultural de la ciutat de Manresa, a la Catalunya Central, al llarg dels segles XIII i XIV, amb el còdex baixmedieval com a fil conductor. L'estudi es basa en l'anàlisi de 305 documents amb mencions libràries (editats conjuntament), pràcticament tots ells inèdits, que procedeixen d'un buidatge exhaustiu dels fons notarials que custodien l'Arxiu Històric Comarcal de Manresa i l'Arx...

Cydia pomonella (L.) (LEPIDOPTERA: TORTRICIDAE). Aspectos de su taxonomía, comportamiento y monitoreo aplicados a programas de control en grandes áreas

OpenAIRE

Fernández, Darío E.

2012-01-01

La carpocapsa [Cydia pomonella (L.) (Lepidoptera: Tortricidae)] és una de les plagues més importants dels fruiters de llavor (pereres, pomeres i codonyers) i dels noguers. El seu control és crític per a assolir una producció sostenible i amb qualitat per a l’exportació. La implementació de programes de control d’abast regional de grans àrees ha demostrat ser una estratègia molt efectiva que permet assolir molt bons resultats de control amb nivell de danys baixos i una reducc...

Plan de comunicación para la ONG Petits Detalls

OpenAIRE

Bello de Haro, Manuel

2017-01-01

Aquest treball tracta sobre un pla de comunicació per a "Petits Detalls", una ONG amb actuació a Uganda que treu endavant projectes autogestionables per al desenvolupament de les comunitats. Està enfocada principalment a ls nens, vol procurar-los educació i salut bàsica, mitjançant la cooperació. Amb aquest pla es busca donar solució a uns problemes de comunicació establint uns objectius, a partir d'aquests una sèrie d'estratègies i finalment unes accions de publicitat i relacions públiques p...

Un bou que era una planta (Bounegre : Bu nerzo/nerjo): contribucióal lèxic tamazight dels Gelida (Argelita, Castelló)

OpenAIRE

Barceló, Miquel

1996-01-01

El nom de la partida rural de Bounegre a Argelita (Castelló), amb un origen desconegut fins ara, és posat en relació amb un terme del lèxic botànic tamazight (berber). El cas concret serveix per començar a caracteritzar la variant dialectal parlada pels Gelida, immigrats a al-Andalus abans del segle X. The place-name of Bounegre (Argelita,Castelló) -up to now without an specific etymologicai identification- is possibly related to a botanichal word of the kabylian boundle of tarnazight. Thi...

Nintendo Papercraft. Del 3D en pantalla al 3D en cartolina

OpenAIRE

Iborra i Mondéjar, Vicent Juli

2013-01-01

XVIII Jornades de Foment de la Investigació de la Facultat de Ciències Humanes i Socials (Any 2013) El marc d'aquest article se centra en els personatges de les consoles Nintendo passats a cartolina. L’anomenat papercraft és una construcció de figures tridimensionals de paper o cartolina, similar a l'origami. No obstant això, difereix de l'origami perquè els seus patrons poden consistir en moltes peces de paper tallades amb tisores o cúter i unides amb cola, cosa que no pot succeir a...

Psicologia social

OpenAIRE

José Marques

2000-01-01

El treball comença explicant què és la psicologia social, condició indispensable per poder veure, a continuació, la relació que hi ha entre la sociolingüística i la psicologia social. Limitem a sis els factors analitzats: els factors socials que influeixen en l'aprenentatge de llengües; la identitat social i l'acomodació, amb una consideració de la teoria de la identitat social formulada per Tajfel; la vitalitat etnolingüística, que té un ventall de correlacions amb aspectes socio...

Competències i factors clau per a l’èxit educatiu des de la perspectiva dels estudiants universitaris fills/es dels immigrants

OpenAIRE

Cano García, Elena

2013-01-01

L’estudi realitzat ha abordat quines són les competències i els factors clau que estudiants universitaris d’origen immigrant consideren que han estat claus per arribar a la universitat, assolint així l’èxit educatiu. S’han escollit estudiants que haguessin fet l’escolaritat obligatòria total o parcialment a Catalunya.Per dur a terme la recerca s’ha treballat amb relats de vida (un total de 13 escrits) i narracions audiovisuals (amb un total de 4 produccions), essent finalment 17 les evidèncie...

Frequência dos tipos de cefaleia no centro de atendimento terciário do Hospital das Clínicas da Universidade Federal de Minas Gerais

OpenAIRE

Silva Junior,Ariovaldo Alberto da; Tavares,Rafael Mattos; Lara,Rodrigo Pinto; Faleiros,Bruno Engler; Gomez,Rodrigo Santiago; Teixeira,Antônio Lúcio

2012-01-01

OBJETIVO: Avaliar a frequência dos diferentes diagnósticos de cefaleias do Ambulatório de Cefaleias do Hospital das Clínicas da Universidade Federal de Minas Gerais (AmbCef-UFMG). MÉTODOS: Estudo transversal e descritivo com 289 pacientes atendidos consecutivamente no AmbCef-UFMG. O diagnóstico da cefaleia baseou-se nos critérios da Classificação Internacional das Cefaleias (ICDH-2004). RESULTADOS: A idade média dos pacientes foi 42,6 anos, sendo a maioria do sexo feminino (86,9%) e com menos...

Debtoid : Una aplicació de gestió de deutes per a Android

OpenAIRE

Bueno Moreno, Víctor

2015-01-01

Aquesta memòria recull l'elaboració d'una aplicació per a dispositius mòbils amb sistema operatiu Android. L'aplicació Debtoid neix com a resultat de les inquietuds personals envers el sistema operatiu Android i la possibilitat de crear una aplicació per registrar pagaments a mitges. L'objectiu final de l'aplicació consisteix en un sistema que permet al dispositiu mòbil registrar els deutes i pagaments introduïts per l'usuari, amb la possibilitat d'enviar a altres usuaris notificacions mitjan...

Relacions tòxiques : Adolescència i dependència afectiva. Causes i conseqüències.

OpenAIRE

Clemente Hernández, Paula

2015-01-01

Les relacions tòxiques entre adolescents i joves són una realitat inqüestionable en el nostre entorn. Això xoca amb una suposada llibertat femenina sexual sense precedents. No obstant això, comportaments abusius, ruptures i retrobaments cíclics, o relacions basades en la dependència extrema dominen la societat. Aquest treball pretén treballar la realitat de les relacions tòxiques com a concepte i introduir-lo com a gran problema social. Per poder, a partir del recull teòric i l'entrevista amb...

Estudio y diseño de una quilla con propela incorporada para la propulsión de una tabla de surf

OpenAIRE

Corpas Amills, Andreu

2018-01-01

El treball desenvolupat en aquest document recull totes les etapes contingudes en la fase de disseny d’una quilla amb propela incorporada. La finalitat d’aquest disseny és proporcionar una impuls extra al surfista mantenint així l’essència del surf; les remades. El principal objectiu del treball doncs, consisteix en reduir l’esforç de la remada d’un surfista. Per fer-ho possible, cal realitzar el disseny d’un prototip de quilla amb les millors prestacions hidrodinàmiques possibles a més a ...

Bitcoin: A source of fairness

OpenAIRE

Torner López, Javier

2017-01-01

El present treball desenvolupa en primer lloc una descripció del funcionament intern de Bitcoin, per donar en una segona part un tractament a la seva aplicació amb finalitats no monetàries, com altres aplicacions de la tecnologia Blockchain en què es basa, centrant-se principalment en el seu ús per implementar aplicacions miltiparte de joc net, com a loteries i càlculs distribuïts amb entrades secretes, en les quals es garanteixi un desenvolupament independent de confiança mútua entre les ...

New chiral liquid crystal with unconventional dioxane terminal unit

Czech Academy of Sciences Publication Activity Database

Perkowski, P.; Bubnov, Alexej; Mrukiewicz, M.; Pociecha, D.; Piecek, W.; Hamplová, Věra; Kašpar, Miroslav

2014-01-01

Roč. 87, 10-11 (2014), s. 1024-1037 ISSN 0141-1594 R&D Projects: GA MŠk 7AMB13PL041; GA MŠk(CZ) LD14007; GA MŠk(CZ) 7AMB14PL035; GA ČR GA13-14133S Grant - others:AV ČR(CZ) M100101211; AVČR(CZ) M100101204; EU - ICT (XE) COST Action IC1208 Institutional support: RVO:68378271 Keywords : chiral liquid crysta * pentaglyform unit * structural properties * smectic phase * hexagonal ordering * self-assembling Subject RIV: JJ - Other Materials Impact factor: 0.954, year: 2014

Quina Agenda 21?

OpenAIRE

García, Ernest

2002-01-01

El programa definit a la Cimera de Rio s'ha desenvolupat amb grans dificultats, augmentades encara més per la dinàmica de mundialització dels mercats. La idea central d'aquest programa, el desenvolupament sostenible, no ha trobat encara una definició conceptual lliure d'equívocs. Una primera fase de debats teòrics ha donat pas a una sèrie d'intents d'elaborar esquemes operacionals, amb la consegüent proliferació de sistemes d'indicadors i mesures integrades, sovint divergents i incompatibles....

Estudio de fabricación de un masterbatch biodegradable

OpenAIRE

Sordo Rebollo, Laura

2014-01-01

En el present Treball Final de Grau es desenvolupa el procés de fabricació d´un masterbatch biodegradable, un concentrat de color per aplicar a polímers biodegradables, concretamente, es tracta d´un masterbatch de color verd fabricat amb base polímèrica de PLA 2003D. Producte relativamente nou, innovador, diferent i amb moltes possiblitats en un futur pròxim, la finalitat principal del qual es fer-se un espai en el mercat dels plàstics convencionals i substituir-los poc a po...

Efecte diferencial de la burnout laboral en diverses professions assistencials: el paper de la personalitat, la salut i el clima social

OpenAIRE

Palau Domingo, Ona

2016-01-01

Aquest estudi va ser dissenyat amb la finalitat de comparar la percepció de la burnout entre quatre col•lectius professionals de la província de Lleida que fan feines assistencials. La mostra estudiada ha estat de 596 subjectes entre 19 i 60 anys (282 mestres, 83 infermers, 60 cuidadors i 171 mossos d’esquadra). La burnout s’ha mesurat amb el Maslach Burnout Inventory; la personalitat s’ha mesurat a través d’un inventari dels cinc grans factors de personalitat (BFQ), i la personalitat resiste...

Theoretical and Experimental Investigation of Force Estimation Errors Using Active Magnetic Bearings with Embedded Hall Sensors

DEFF Research Database (Denmark)

Voigt, Andreas Jauernik; Santos, Ilmar

2012-01-01

to ∼ 20% of the nominal air gap the force estimation error is found to be reduced by the linearized force equation as compared to the quadratic force equation, which is supported by experimental results. Additionally the FE model is employed in a comparative study of the force estimation error behavior...... of AMBs by embedding Hall sensors instead of mounting these directly on the pole surfaces, force estimation errors are investigated both numerically and experimentally. A linearized version of the conventionally applied quadratic correspondence between measured Hall voltage and applied AMB force...

Sobre el teorema fonamental de l’àlgebra

OpenAIRE

Font i Reverter, Jordi

2016-01-01

El teorema fonamental de l àlgebra és un enunciat matemàtic que s ha fet servir en múltiples ocasions durant la carrera. No obstant mai s hi ha dedicat temps a fer-li un estudi detallat, com a molt alguna demostració de passada. Aquest treball es basa en provar el teorema amb diferents eines apreses durant el grau en matemàtiques. La idea principal és que es pugui utilitzar per fer-lo arribar amb més facilitat a l alumnat.

Formal Multilevel Hierarchical Verification of Synchronous MOS VLSI Circuits.

Science.gov (United States)

1987-06-01

Thoasietor R.AMbS .. ................... 166 12.2 Bootstrap Driver ... . .. .. .. .................. 167 List of Tables 1.1 TheSigalLvelVrusthe Dgtal Lvel ...THIS RESEARCH 35 Protocols Functional Lvel Sequential Systes 0io" L"ve Figure 1.7: Silica Pithecus’s place in the verifier community. The only direct...athematial structere underlyisg it behavior When thin mathematical structue is sot mae explicis a weaiw will eithe fadl or sakea very .Mg time. The

Diseño de metodologías para la adquisición de resonancia magnética funcional a 1,5t

OpenAIRE

Guiu Hernández, Esther

2009-01-01

Projecte fet en col.laboració amb Pontificia Universidad Católica de Chile. Escuela de Ingeniería La resonancia magnética funcional (fMRI) es una técnica mediante la cual se puede mapear el cerebro, tanto anatómica como fisiológicamente, sin necesidad de realizar estudios invasivos. A fin de obtener mapas de activación cerebral, el sujeto en estudio debe realizar alguna tarea o estar expuesto a un estímulo externo. Paralelamente se adquieren, mediante resonancia magnética, una gran cantida...

Correlação entre a dinamometria e teste funcional em atletas de handebol

Directory of Open Access Journals (Sweden)

Fabiano Fernandes da Silva

2014-06-01

Full Text Available INTRODUÇÃO: São poucas as informações que relacionam testes funcionais com testes mais precisos, como a dinamometria isocinética. OBJETIVO: Correlacionar as variáveis isocinéticas pico de torque (PT, potência média (PM e trabalho total (TT de rotadores internos de ombro em atletas de handebol do gênero masculino com o teste funcional de arremesso de medicine ball (AMB. MÉTODOS: Participaram desse estudo 25 atletas amadores de handebol do gênero masculino com idade média 17,72 ± 2,16 anos. A coleta de dados foi realizada em dois dias diferentes, respeitando intervalo mínimo de 48 horas entre as sessões. De maneira aleatória, definida por sorteio, os atletas faziam o teste isocinético ou o teste de AMB. Para o teste de AMB, o atleta deveria arremessar uma medicine ball de 3 kg a maior distância possível. Para análise isocinética, foram utilizadas as velocidades de 60°/s e 180°/s avaliando a capacidade muscular dos músculos rotadores internos de ombro. Para análise de associações foram utilizados os testes de correlação de Pearson e regressão linear simples. RESULTADOS: Foram observadas associações moderadas (0,60 ≤ r < 0,70; p<0,05 para as variáveis PT, PM e TT e o teste de AMB na velocidade de 60°/s. Além disso, observaram-se associações altas (r ≥ 0,70; p<0,05 entre as variáveis estudadas na velocidade de 180°/s. CONCLUSÃO: As variáveis isocinéticas PT, PM e TT, de rotadores internos de ombro do braço dominante de atletas de handebol do gênero masculino apresentam correlação moderada a alta com o teste funcional de AMB.

Properties of the photodiode PiN as neutron detector

International Nuclear Information System (INIS)

Adamiec, G.; Iniguez, M.P.; Lorente, A.; Gallego, E.; Voytchev, M.

2005-01-01

The photodiode can be used to measure the ambient dose equivalent for an Am-Be source, as well placed in a paraffin sphere with LiF 6 converter as nude with a PE converter. The ratio between the counting rate and the ambient dose equivalent is linear in the two cases. The sensitivity of the diode with the converter 6 LiF is evaluated to 8.4 shocks by micro sievert by square centimeter of active surface of diode. The photodiode with the PE converter has a sensitivity lower of 2.1 shocks by micro sievert by square centimeter (for the Am-Be source) of active surface of diode. About the disadvantages, the disadvantage of photodiode inside the paraffin sphere is its size and weight; the disadvantage of the diode with the PE converter is its sensitivity to the orientation of the neutron flux and the necessity to calibrate for the source type. (N.C.)

Muons in air showers at the Pierre Auger Observatory: measurement of atmospheric production depth

Czech Academy of Sciences Publication Activity Database

Aab, A.; Abreu, P.; Aglietta, M.; Boháčová, Martina; Chudoba, Jiří; Ebr, Jan; Mandát, Dušan; Nečesal, Petr; Palatka, Miroslav; Pech, Miroslav; Prouza, Michael; Řídký, Jan; Schovánek, Petr; Trávníček, Petr; Vícha, Jakub

2014-01-01

Roč. 90, č. 1 (2014), "012012-1"-"012012-15" ISSN 1550-7998 R&D Projects: GA ČR(CZ) GA14-17501S; GA MŠk(CZ) 7AMB14AR005; GA MŠk(CZ) LG13007 Institutional support: RVO:68378271 Keywords : Pierre Auger Observatory * detector * cosmic rays * muons * air shower s Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 4.643, year: 2014

Highly enhanced vapor sensing of multi-walled carbon nanotube network sensors by n-butylamine functionalization

Czech Academy of Sciences Publication Activity Database

Slobodian, P.; Říha, Pavel; Cavallo, P.; Barbero, C.A.; Cvelbar, U.; Benlikaya, R.; Petras, D.; Sáha, P.

2014-01-01

Roč. 2014, August (2014), Article ID 589627 ISSN 1687-4110 Grant - others:UTB Zlín(CZ) IGA/FT/2014/013; GA MŠk(CZ) ED2.1.00/03.0111; GA MŠk(CZ) 7AMB13AR019 Institutional support: RVO:67985874 Keywords : carbon nanotube (CNT) * multiwall carbon nanotube (MWCNT) * nanotube networks * volatile organic compounds (VOC) Subject RIV: BK - Fluid Dynamics Impact factor: 1.644, year: 2014

Monte Carlo Simulation on Compensated Neutron Porosity Logging in LWD With D-T Pulsed Neutron Generator

International Nuclear Information System (INIS)

Zhang Feng; Hou Shuang; Jin Xiuyun

2010-01-01

The process of neutron interaction induced by D-T pulsed neutron generator and 241 Am-Be source was simulated by using Monte Carlo method. It is concluded that the thermal neutron count descend exponentially as the spacing increasing. The smaller porosity was, the smaller the differences between the two sources were. When the porosity reached 40%, the ratio of thermal neutron count generated by D-T pulsed neutron source was much larger than that generated by 241 Am-Be neutron source, and its distribution range was wider. The near spacing selected was 20-30 cm, and that of far spacing was about 60-70 cm. The detection depth by using D-T pulsed neutron source was almost unchanged under condition of the same sapcing, and the sensitivity of measurement to the formation porosity decreases. The results showed that it can not only guarantee the statistic of count, but also improve detection sensitivity and depth at the same time of increasing spacing. Therefore, 241 Am-Be neutron source can be replaced by D-T neutron tube in LWD tool. (authors)

[Fungal infectivities of implanted catheters due to Candida sp. Biofilms formation and resistance].

Science.gov (United States)

Seddiki, S M L; Boucherit-Otmani, Z; Boucherit, K; Kunkel, D

2015-06-01

Candidemia are the most common fungal infections in hospitals. However, the catheters are subject to be altered by Candida biofilms which increase the risk of invasive nosocomial infections due to the high resistance to antifungal agents. Therefore, the minimum inhibitory concentrations of planktonic (MIC) and sessile cells (CIMS) were evaluated. To review the in vivo biofilms structures of Candida sp. formed on the inner and/or external surfaces of collected catheters, we used scanning electron microscopy (SEM). The level of biofilm resistance was assessed against two conventional antifungal agents: amphotericin B (AmB), which belongs to the class of polyenes, and fluconazole (FLZ) which is an azole. The SEM observation of biofilms of Candida sp. reveals complex structures. Compared to MICs, the calculation of CIMS showed an increase of 32 times with AmB and of 128 times with FLZ. Catheters offer an ideal surface to Candida sp. to form biofilms. This complex structure induces the increase of the resistance of sessile cells against two antifungal agents, AmB and FLZ. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

MCNP SIMULATION OF THE HP(10) ENERGY RESPONSE OF A BRAZILIAN TLD ALBEDO NEUTRON INDIVIDUAL DOSEMETER, FROM THERMAL TO 20 MeV.

Science.gov (United States)

Freitas, B M; Martins, M M; Pereira, W W; da Silva, A X; Mauricio, C L P

2016-09-01

The Brazilian Instituto de Radioproteção e Dosimetria (IRD) runs a neutron individual monitoring system with a home-made TLD albedo dosemeter. It has already been characterised and calibrated in some reference fields. However, the complete energy response of this dosemeter is not known, and the calibration factors for all monitored workplace neutron fields are difficult to be obtained experimentally. Therefore, to overcome such difficulties, Monte Carlo simulations have been used. This paper describes the simulation of the HP(10) neutron response of the IRD TLD albedo dosemeter using the MCNPX transport code, for energies from thermal to 20 MeV. The validation of the MCNPX modelling is done comparing the simulated results with the experimental measurements for ISO standard neutron fields of (241)Am-Be, (252)Cf, (241)Am-B and (252)Cf(D2O) and also for (241)Am-Be source moderated with paraffin and silicone. Bare (252)Cf are used for normalisation. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Transició i orientació: Interrelacions, estratègies i recomanacions des de la investigació

Directory of Open Access Journals (Sweden)

Pilar Figuera Gazo

2015-07-01

Full Text Available La investigació centrada en els problemes de la transició ha motivat els autors d'aquest assaig a compartir amb els seus col·legues nacionals i internacionals les seves troballes i les seves innovacions. L'article revisa el concepte de transició des d'una perspectiva múltiple i sintetitza diferents investigacions fetes aquesta última dècada per l'equip Transicions Acadèmiques i Laborals (TRALS. Unes, centrades en transicions convencionals i d’altres en problemes no tan convencionals. L'anàlisi, molt succinta, de les investigacions més significatives exposa els objectius, la metodologia, les característiques i les fonts de cada treball. Les repercussions de diferents investigacions en la política educativa global de l'evitació del abandonisme escolar i acadèmic, es veuen complementades amb una sèrie de suggeriments per la intervenció psicopedagógica, amb l’objectiu d’orientar a persones en transició seguint models didàctics i psicològics d'autors clàssics en el tema.

Increasing the Fungicidal Action of Amphotericin B by Inhibiting the Nitric Oxide-Dependent Tolerance Pathway

Directory of Open Access Journals (Sweden)

Kim Vriens

2017-01-01

Full Text Available Amphotericin B (AmB induces oxidative and nitrosative stresses, characterized by production of reactive oxygen and nitrogen species, in fungi. Yet, how these toxic species contribute to AmB-induced fungal cell death is unclear. We investigated the role of superoxide and nitric oxide radicals in AmB’s fungicidal activity in Saccharomyces cerevisiae, using a digital microfluidic platform, which enabled monitoring individual cells at a spatiotemporal resolution, and plating assays. The nitric oxide synthase inhibitor L-NAME was used to interfere with nitric oxide radical production. L-NAME increased and accelerated AmB-induced accumulation of superoxide radicals, membrane permeabilization, and loss of proliferative capacity in S. cerevisiae. In contrast, the nitric oxide donor S-nitrosoglutathione inhibited AmB’s action. Hence, superoxide radicals were important for AmB’s fungicidal action, whereas nitric oxide radicals mediated tolerance towards AmB. Finally, also the human pathogens Candida albicans and Candida glabrata were more susceptible to AmB in the presence of L-NAME, pointing to the potential of AmB-L-NAME combination therapy to treat fungal infections.

Aspectos fundamentais no desenvolvimento de sistemas microemulsionados contendo anfotericina B para uso oftálmico

Directory of Open Access Journals (Sweden)

Walteçá Louis Lima Silveira

2013-01-01

Full Text Available A exemplo do que ocorre com outros fármacos, a biodisponibilidade da anfotericina B (AmB através da via ocular repreesenta um grande desafio para a pesquisa científica. Na verdade, a baixa biodisponibilidade apresentada por tal molécula é devido, principalmente, a presença das barreiras oculares que impedem a absorção deste fármaco para os tecidos internos. A toxicidade associada a este fármaco, assim como a sua baixa capacidade em permear a córnea íntegra também consiste em um problema associado ao seu uso clínico. Novos veículos seguros e eficazes para a liberação ocular da AmB são, portanto, necessários. As microemulsões (MEs aparecem como um interessante sistema devido à sua transparência, estabilidade termodinâmica e favorável viscosidade. O conhecimento do processo de formação das MEs contendo AmB, assim como a compreensão de toda a sua caracterização físicoquímica correspondem a aspectos importantes para se determinar as condições favoráveis para que estes sistemas venham a ser empregados como colírios. Esta revisão tem como objetivo, portanto, abordar este tema enfatizando os principais aspectos relacionados com a utilização de MEs como sistemas de liberação para a AmB através da via tópica oftálmica.

Espai públic en polígons d’habitatge: Montbau i Ciutat Meridiana (Barcelona

Directory of Open Access Journals (Sweden)

José Luis Castro Mellado

2017-10-01

Full Text Available A Barcelona, els polígons d’habitatge massiu van evolucionant en diferents tipologies que culminen en el període de màxima immigració entre els anys 52 i 75, amb la major producció d’habitatge i el desenvolupament de grans conjunts que es desenvolupen sobre la base de la ciutat funcional, l’estandardització de la unitat d’habitatge com a estratègia d’eficiència econòmica i el caràcter unitari de les operacions, el que en termes tipològics es tradueix en l’adopció d’una composició repetitiva i seriada sobre la base del bloc aïllat i amb espais de gran extensió entre les edificacions destinats a àrea verda, el qual porta com a conseqüència problemes amb una posició desarticulada amb la resta del teixit urbà, poca definició de l’espai públic, manca d’equipaments i infraestructura col·lectiva. L’aplicació d’aquest estàndard com a solució eficient a la demanda d’habitatge des d’un aspecte quantitatiu, va tenir com a conseqüència conjunts urbans que tindran diferents resultats en els seus processos d’integració futura a la ciutat, per la qual cosa es fa necessari determinar i descobrir quines són aquests altres factors que faciliten o dificulten el conjunt d’esdeveniments i processos per transformar-se en peces de ciutat

Coating nanodiamonds with biocompatible shells for applications in biology and medicine

Czech Academy of Sciences Publication Activity Database

Neburková, Jitka; Vávra, Jan; Cígler, Petr

2017-01-01

Roč. 21, č. 1 (2017), s. 43-53 ISSN 1359-0286 R&D Projects: GA ČR(CZ) GA16-16336S; GA MZd(CZ) NV15-33094A; GA MŠk(CZ) 7AMB16FR029 Institutional support: RVO:61388963 Keywords : polymer * core- shell * antifouling Subject RIV: CD - Macromolecular Chemistry OBOR OECD: Polymer science Impact factor: 6.938, year: 2016

Probing the radio emission from air showers with polarization measurements

Czech Academy of Sciences Publication Activity Database

Aab, A.; Abreu, P.; Aglietta, M.; Boháčová, Martina; Chudoba, Jiří; Ebr, Jan; Mandát, Dušan; Nečesal, Petr; Nožka, Libor; Palatka, Miroslav; Pech, Miroslav; Prouza, Michael; Řídký, Jan; Schovánek, Petr; Trávníček, Petr; Vícha, Jakub

2014-01-01

Roč. 89, č. 5 (2014), "052002-1"-"052002-18" ISSN 1550-7998 R&D Projects: GA MŠk(CZ) LG13007; GA TA ČR TA01010517; GA MŠk(CZ) 7AMB12AR013 Institutional support: RVO:68378271 Keywords : Pierre Auger Observatory * detector * cosmic rays Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 4.643, year: 2014

L'aprenentatge basat en problemes. Desenvolupat

OpenAIRE

Font Ribas, Antoni; Ramírez i Sunyer, Josep Ignasi

2016-01-01

L’aprenentatge basat en problemes (ABP). 1. En què consisteix l’ABP?. 2. Les fases del treball amb l’ABP . 3. El problema. 4. El tutor. 5. L’avaluació . 6. L’ABP en grups grans. 7. Avantatges i limitacions de l’ABP. Problemes per a l’aprenentatge en el grau de Bioquímica . L’aprenentatge del Dret basat en problemes

Macroclumping as solution of the discrepancy between Hα and P v mass loss diagnostics for O-type stars

Czech Academy of Sciences Publication Activity Database

Šurlan, Brankica; Hamann, W.-R.; Aret, A.; Kubát, Jiří; Oskinova, L.M.; Torres, A.F.

2013-01-01

Roč. 559, November (2013), A130/1-A130/17 ISSN 0004-6361 R&D Projects: GA ČR(CZ) GAP209/11/1198; GA MŠk 7AMB12AR021 Grant - others: NASA (US) NNX09AF08G Institutional support: RVO:67985815 Keywords : stars * winds * outflows Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.479, year: 2013

Photoluminescent polysaccharide-coated germanium(IV) oxide nanoparticles

Czech Academy of Sciences Publication Activity Database

Lobaz, Volodymyr; Rabyk, Mariia; Pánek, Jiří; Doris, E.; Nallet, F.; Štěpánek, Petr; Hrubý, Martin

2016-01-01

Roč. 294, č. 7 (2016), s. 1225-1235 ISSN 0303-402X R&D Projects: GA MŠk(CZ) 7AMB14FR027; GA ČR(CZ) GA13-08336S; GA MZd(CZ) NV15-25781A Institutional support: RVO:61389013 Keywords : germanium oxide nanoparticles * polysaccharide coating * photoluminescent label Subject RIV: CD - Macromolecular Chemistry Impact factor: 1.723, year: 2016

Exploring the circumstellar disk-like structure of the B[e] supergiant LHA 120-S 73

Czech Academy of Sciences Publication Activity Database

Torres, A.F.; Cidale, L.S.; Kraus, Michaela; Arias, M.L.; Maravelias, Grigorios; Borges Fernandes, M.; Vallverdú, R.

2016-01-01

Roč. 58, č. 1 (2016), s. 120-122 E-ISSN 1669-9521 R&D Projects: GA MŠk(CZ) 7AMB14AR017; GA MŠk LG14013 Institutional support: RVO:67985815 Keywords : stars * early-type * circumstellar matter Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics http://www.astronomiaargentina.org.ar/b58/2016baaa...58...120T.pdf

Searches for anisotropies in the arrival directions of the highest energy cosmic rays detected by the Pierre Auger Observatory

Czech Academy of Sciences Publication Activity Database

Aab, A.; Abreu, P.; Aglietta, M.; Boháčová, Martina; Chudoba, Jiří; Ebr, Jan; Mandát, Dušan; Nečesal, Petr; Palatka, Miroslav; Pech, Miroslav; Prouza, Michael; Řídký, Jan; Schovánek, Petr; Trávníček, Petr; Vícha, Jakub

2015-01-01

Roč. 804, č. 1 (2015), s. 15 ISSN 0004-637X R&D Projects: GA MŠk(CZ) LG13007; GA MŠk(CZ) 7AMB14AR005; GA ČR(CZ) GA14-17501S Institutional support: RVO:68378271 Keywords : acceleration of particles * astroparticle physics Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 5.909, year: 2015

A mini atlas of K-band spectra of southern symbiotic stars

Czech Academy of Sciences Publication Activity Database

Marchiano, P.E.; Cidale, L.S.; Arias, M.L.; Borges Fernandes, M.; Kraus, Michaela

2015-01-01

Roč. 57, č. 1 (2015), s. 87-89 E-ISSN 1669-9521 R&D Projects: GA ČR(CZ) GA14-21373S; GA MŠk(CZ) 7AMB14AR017 Institutional support: RVO:67985815 Keywords : binaries * symbiotic * stars Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics http://www. astronomia argentina.org.ar/b57/2015BAAA...57...87M.pdf

Carbon nanotubes overgrown and ingrown with nanocrystalline diamonddeposited by different CVD plasma systems

Czech Academy of Sciences Publication Activity Database

Varga, Marián; Vretenár, V.; Ižák, Tibor; Skákalová, V.; Kromka, Alexander

2014-01-01

Roč. 251, č. 12 (2014), s. 2413-2419 ISSN 0370-1972 R&D Projects: GA ČR(CZ) GBP108/12/G108; GA MŠk(CZ) 7AMB14SK037 Institutional support: RVO:68378271 Keywords : carbon nanotubes * chemical vapour deposition * composites * gas composition * nanocrystalline diamond Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.489, year: 2014

3-Bromopyruvate as an Alternative Option for the Treatment of Protothecosis.

Science.gov (United States)

Jagielski, Tomasz; Niedźwiecka, Katarzyna; Roeske, Katarzyna; Dyląg, Mariusz

2018-01-01

Protothecosis is an unusual infection of both humans and animals caused by opportunistically pathogenic microalgae of the genus Prototheca . Until now, no standardized treatment protocols exist for the protothecal disease, boosted by a remarkable resistance of Prototheca spp. to a wide array of antimicrobial agents currently available in clinical use. Consequently, there is an urgent need for new effective drugs against Prototheca algae. In this study, the anti- Prototheca activity of 3-bromopyruvate (3BP), either alone or in combination with amphotericin B (AMB) was assessed in vitro , as well as the cytotoxicity of 3BP toward the bovine mammary epithelial cells and murine skin fibroblasts. The mean minimum inhibitory concentrations (MIC) and minimum algaecidal concentrations (MAC) were 0.85 ± 0.21 and 2.25 ± 0.54 mM for Prototheca wickerhamii , 1.25 ± 0.47 and 4.8 ± 1.03 mM for Prototheca blaschkeae , and 1.55 ± 0.69 and 5.6 ± 1.3 mM for Prototheca zopfii gen. 2, respectively. For all Prototheca strains tested, a synergistic interaction between 3BP and AMB was observed, resulting in about 4-fold reduction of their individual MICs, when used together. The elevated content of intracellular glutathione (GSH) was associated with a decreased susceptibility to 3BP. Both epithelial and fibroblast cells retained high viability upon treatment with 3BP at concentrations equivalent to the highest MIC recorded (3 mM) and 10-fold higher (30 mM), with the mean cell viability exceeding 80%, essentially the same as for the untreated cells. The results from these in vitro studies emphasize the high activity of 3BP against the Prototheca algae, its synergistic effect when used in combination with AMB, and the safety of the drug toward the tested mammalian cells. Along with the advantageous physico-chemical and pharmacokinetic properties, 3BP may be considered an effective and safe novel agent against the protothecal disease.

3-Bromopyruvate as an Alternative Option for the Treatment of Protothecosis

Directory of Open Access Journals (Sweden)

Tomasz Jagielski

2018-04-01

Full Text Available Protothecosis is an unusual infection of both humans and animals caused by opportunistically pathogenic microalgae of the genus Prototheca. Until now, no standardized treatment protocols exist for the protothecal disease, boosted by a remarkable resistance of Prototheca spp. to a wide array of antimicrobial agents currently available in clinical use. Consequently, there is an urgent need for new effective drugs against Prototheca algae. In this study, the anti-Prototheca activity of 3-bromopyruvate (3BP, either alone or in combination with amphotericin B (AMB was assessed in vitro, as well as the cytotoxicity of 3BP toward the bovine mammary epithelial cells and murine skin fibroblasts. The mean minimum inhibitory concentrations (MIC and minimum algaecidal concentrations (MAC were 0.85 ± 0.21 and 2.25 ± 0.54 mM for Prototheca wickerhamii, 1.25 ± 0.47 and 4.8 ± 1.03 mM for Prototheca blaschkeae, and 1.55 ± 0.69 and 5.6 ± 1.3 mM for Prototheca zopfii gen. 2, respectively. For all Prototheca strains tested, a synergistic interaction between 3BP and AMB was observed, resulting in about 4-fold reduction of their individual MICs, when used together. The elevated content of intracellular glutathione (GSH was associated with a decreased susceptibility to 3BP. Both epithelial and fibroblast cells retained high viability upon treatment with 3BP at concentrations equivalent to the highest MIC recorded (3 mM and 10-fold higher (30 mM, with the mean cell viability exceeding 80%, essentially the same as for the untreated cells. The results from these in vitro studies emphasize the high activity of 3BP against the Prototheca algae, its synergistic effect when used in combination with AMB, and the safety of the drug toward the tested mammalian cells. Along with the advantageous physico-chemical and pharmacokinetic properties, 3BP may be considered an effective and safe novel agent against the protothecal disease.

Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation in ERG11 and Exhibiting Cross-Resistance to Azoles and Amphotericin B

Science.gov (United States)

Hull, Claire M.; Parker, Josie E.; Bader, Oliver; Weig, Michael; Gross, Uwe; Warrilow, Andrew G. S.; Kelly, Diane E.

2012-01-01

We identified a clinical isolate of Candida glabrata (CG156) exhibiting flocculent growth and cross-resistance to fluconazole (FLC), voriconazole (VRC), and amphotericin B (AMB), with MICs of >256, >256, and 32 μg ml−1, respectively. Sterol analysis using gas chromatography-mass spectrometry (GC-MS) revealed that CG156 was a sterol 14α-demethylase (Erg11p) mutant, wherein 14α-methylated intermediates (lanosterol was >80% of the total) were the only detectable sterols. ERG11 sequencing indicated that CG156 harbored a single-amino-acid substitution (G315D) which nullified the function of native Erg11p. In heterologous expression studies using a doxycycline-regulatable Saccharomyces cerevisiae erg11 strain, wild-type C. glabrata Erg11p fully complemented the function of S. cerevisiae sterol 14α-demethylase, restoring growth and ergosterol synthesis in recombinant yeast; mutated CG156 Erg11p did not. CG156 was culturable using sterol-free, glucose-containing yeast minimal medium (glcYM). However, when grown on sterol-supplemented glcYM (with ergosta 7,22-dienol, ergosterol, cholestanol, cholesterol, Δ7-cholestenol, or desmosterol), CG156 cultures exhibited shorter lag phases, reached higher cell densities, and showed alterations in cellular sterol composition. Unlike comparator isolates (harboring wild-type ERG11) that became less sensitive to FLC and VRC when cultured on sterol-supplemented glcYM, facultative sterol uptake by CG156 did not affect its azole-resistant phenotype. Conversely, CG156 grown using glcYM with ergosterol (or with ergosta 7,22-dienol) showed increased sensitivity to AMB; CG156 grown using glcYM with cholesterol (or with cholestanol) became more resistant (MICs of 2 and >64 μg AMB ml−1, respectively). Our results provide insights into the consequences of sterol uptake and metabolism on growth and antifungal resistance in C. glabrata. PMID:22615281

Development of new type boron-coating proportional counter and its experimental investigation and simulation calculation

International Nuclear Information System (INIS)

Zhang Zixia; Wei Zhiyong; Fang Meihua; Qiang Peng; Zhu Li; Chen Guoyun

2015-01-01

Three materials wherein suitable proportion of isotope enriched 10 B powder, 1, 2-ethylene dichloride and formvar resin were blended to make 10 B neutron sensitive coating by oneself. A new type proportional counter that coated with 10 B neutron sensitive coating was made. Furthermore, in order to increase the character and quality of the neutron detector, a set of 14 annulus epoxy sheets which were sided with 10 B film were placed in the tube. A series performance tests were done by 241 Am-Be neutron source. The tests of 3.7 × 10 9 Bq 211 Am-Be neutron source show that the plateau length of detector is 150 V from 750 V to 900 V, while the plateau slope is 8.2%/100 V. When the working voltage is 800 V, the count rate of new type boron-coating proportional counter is 50 s -1 . The level of sensitivity is 0.71 cm 2 . Compared with the detector only coated with 10 B film in the inner walls of detector, neutron sensitivity area of the new detector increases to 3.15 times. The results show that the plateau length increases from 80 V to 150 V, and the plateau slope is improved from 12.4%/100 V to 7.58%/100 V, while the neutron sensitivity increases to 2.63 times. Using Geant4 software based on Monte Carlo method, this paper presented the response and detection efficiency of new type boron-coating proportional counter, which was covered with φ55 mm × 250 mm cylinder high density polyethylene moderator material. The simulation results of Geant4 are in agreement with the results of 241 Am-Be neutron source experiment. It shows the reliability of simulation application. (authors)

The ambivalent relation between state and illegal actors: piracy retail in Mexico A relação ambígua entre o Estado e os atores ilegais: o mercado da pirataria no México

Directory of Open Access Journals (Sweden)

José Carlos G. Aguiar

2011-02-01

Full Text Available In the rise of democratic governments across Latin America, the neoliberal law-and-order perspective has been the most influential model of security in the region. This approach is based on the opposition between state and illegal agents, as if they were two different sets of actors. Influenced by this model, Mexican president Vicente Fox launched an extensive anti-piracy programme to eradicate retail of counterfeit. Based on ethnographic material gathered in the San Juan de Dios market in Guadalajara, I discuss on the exchanges between piracy sellers and police officers. My argument is that law enforcement programmes have not affected the political economy of corruption, they overlook the net of ambiguous loyalties where state and illegal actors are entrenched. The anthropology of the state provides the rationale for a critique on neoliberal security policies.Quando surgiram os governos democráticos na América Latina, a perspetiva neoliberal da lei e da ordem constituiu-se como o modelo de segurança dominante na região. Esta abordagem baseia-se na oposição entre o Estado e os agentes da ilegalidade, como se fossem dois conjuntos de atores distintos. Influenciado por este modelo, o presidente mexicano Vicente Fox lançou um programa alargado contra a pirataria, pretendendo erradicar a venda da contrafação. A partir de material etnográfico recolhido no mercado de San Juan de Dios, em Guadalajara, examino as interações entre vendedores de mercadoria pirata e agentes da polícia. Argumento que os programas para a aplicação da lei não afetaram a economia política da corrupção e que ignoram a rede de lealdades ambíguas que envolvem o Estado e os atores ilegais. A antropologia do Estado oferece os princípios para uma crítica sobre as políticas de segurança neoliberais.

Disseny d’actuacions per a la millora de la mobilitat i de la gestió del transport de superfície a la ciutat de Barcelona

OpenAIRE

Castellví Moyes, Montserrat

2010-01-01

L’objectiu d’aquest projecte és fer un anàlisi comparatiu del carril bus de Barcelona amb el de dues ciutats europees, Londres i Brussel·les. Per altra banda també s’aportaran propostes de millora per a un punt conflictiu concret de la xarxa de carril bus de Barcelona, la plaça Francesc Macià. Per la primera part del projecte s’ha hagut de contactar amb les entitats encarregades del transport de Londres (TfL) i de Brussel·les (Stib) per tal de recopilar les dades necessàries ...

Danses històriques: una alternativa interdisciplinària

OpenAIRE

Cañabate Ortiz, Dolors; Rigau, Mercè

1997-01-01

Sovint sentim parlar sobre la interdisciplinarietat entre la música i l’educació física. Per això ens hem animat a oferir-vos una experiència viscuda a l’Arc, taller de música de Barcelona, amb alumnes de Música i d’Educació Física, a càrrec de la professora Anna Yepes. L’experiència es va basar a relacionar el llenguatge musical amb el llenguatge corporal. Els alumnes tocaven i dansaven alternativament les danses històriques, experimentant com el llenguatge musical, la forma, el temps corres...

Diseño y construcción de un convertidor de potencia para la transmisión inalámbrica de energía

OpenAIRE

Borrallo Maldonado, Víctor

2016-01-01

En el present projecte, s’ha dissenyat i posteriorment construït un convertidor de potència. Concretament un ondulador, en configuració de mig pont amb una càrrega ressonant LC per a la transmissió sense fils d’energia. D’altra banda, s’ha desenvolupat també un receptor amb la mateixa configuració que la càrrega ressonant de l’ondulador. Mitjançant acoblament magnètic entre les bobines de l’emissor i el receptor, les quals funcionen com a antenes, es transmet l’energia al receptor. Tot ...

Análisis de la normativa y aplicación de auditorías energéticas térmicas en el sector industrial

OpenAIRE

Brau Morales, Guillem

2011-01-01

El present projecte tracta d'analitzar les auditories energètiques tèrmiques aplicades al sector industrial, des d'un punt de vista d'aplicació i també normatiu. Per a dur-ho a terme s'analitzarà l'eina informàtica EINSTEIN, desenvolupada en el si d'un consorci europeu que compta amb una àmplia experiència en el subministrament eficient d'energia tèrmica. S'estudiarà la seva metodologia d'auditoria i les seves qualitats com a eina informàtica. També es realitzarà una comparació amb altres ...

L'influx de Hofstadter sobre una versió nova del compatibilisme

OpenAIRE

Beltran Munar, Miquel A.

1993-01-01

Una de les idees principals dels llibres més venuts de Hofstadter Gödel, Escher, Bach: un Etern Or Braid és la seva concepció de l'estranya bucle. Aquest article és sobre l'ús que Michael Morden fa d'aquesta idea, tot argumentant a favor de compatibilisme (la doctrina segons la qual el lliure albir és compatible amb el determinisme) contra algunes crítiques formulades pel llibertarisme. Amb la idea de l'auto-referència com a guia, el lliure albir és vist com els símbols de la ment. En ...

La inteligencia emocional y el ajuste psicológico: un estudio transcultural

OpenAIRE

Fulquez Castro, Sandra Carina

2011-01-01

La intel·ligència emocional (IE) és una competència de l'ésser humà. Així mateix, elements psicològics com l'autoestima, l-autoconfiança, les relacions amb els iguals i les relacions amb els pares -en el cas dels adolescents- constitueixen eines que guien la salut mental i l'adaptació social de l'individu. L'estudi que es presenta demostra l'associació existent entre la IE (atenció emocional -AE- claredat emocional -CE- i reparació emocional -RE) i les variables d'ajust psicològic, així com d...

Gelatin coated hybrid lipid nanoparticles for oral delivery of amphotericin B

DEFF Research Database (Denmark)

Jain, Sanyog; Valvi, Pankaj U; Swarnakar, Nitin K

2012-01-01

Amphotericin B (AmB) loaded polymer lipid hybrid nanoparticles (AmB-PLNs) comprised of lecithin (anionic lipid) and gelatin (Type A, cationic below its isoelectric point 7.0-9.0) were prepared by a two-step desolvation method to improve the oral bioavailability of AmB. The optimized AmB-PLNs were......) and fluorescent resonance energy transfer (FRET) analysis confirmed the orientation of the lecithin (located in the core) and gelatin (exterior coat) within the system. The developed formulation exhibited a sustained drug release profile with a release pattern best fitted to Higuchi kinetics. Experiments on Caco...

Modificacions de les Propietats Fisicoquímiques de les "Lies" de Segona Fermentació durant la Criança del Cava

OpenAIRE

Gallardo Chacón, Joan Josep

2010-01-01

[cat] Els caves són vins escumosos que es distingeixen per la seva criança particular en contacte amb els llevats de la segona fermentació per un període no inferior a 9 mesos. Com més es perllonga la criança, se suposa una millor qualitat del vi. Així, la categoria “Gran Reserva” implica com a mínim 30 mesos d’envelliment en rima. Tanmateix, encara no s'han esclarit els mecanismes que involucren l’autòlisi amb la qualitat organolèptica dels vins escumosos. En aquest treball s’ha proposat...

Movilidad y vida cotidiana : la construcción del espacio doméstico en las comunidades de la prehistoria reciente del nordeste de Iberia

OpenAIRE

Gonzalez Marcén, Paloma; Montón Subías, Sandra; Picazo Gurina, Marina

2005-01-01

En aquest article s'analitzen els canvis que experimentà l'organització de les activitats de manteniment en els assentaments litorals i prelitorals del nord-est de la península Ibèrica, des del segle VIII fins el segle III aC, i el que implicaren aquestes transformacions en les pautes de mobilitat de les dones. Amb aquest objectiu, es considera l'evidència arqueològica dels assentaments del Bronze final i de l'Edat del Ferro al Vallès i l'Empordà. Aquests canvis es posen en relació amb el mar...

Cultura lúdica i pràctiques mediàtiques

Directory of Open Access Journals (Sweden)

Elisenda Ardèvol

2007-05-01

Full Text Available En aquest article volem explorar la relació entre els videojocs i altres pràctiques relacionades amb els mitjans audiovisuals en la vida quotidiana; en concret, ens interessa examinar fins a quin punt el videojoc, com a forma cultural que combina la narració audiovisual i el plaer del joc, pot ser útil per a comprendre transformacions culturals més àmplies en relació amb la producció cultural en el nou context mediàtic que obren les tecnologies de la informació i de la comunicació. Text complet (PDF

Disseny i prototipatge d'un programari per l'ús dels dispositius mòbils en l'aprenentatge online

OpenAIRE

Cartanyà Yárnoz, Ana

2012-01-01

L'objectiu d'aquest projecte és crear una aplicació per dispositius mòbils que permeti interactuar amb Moodle, un entorn d'aprenentatge en línia. Actualment s'ha estès molt els smartphones, i cada vegada hi ha més gent connectada al mon web les 24h amb aquests aparells. I s'estan acostumant a rebre alertes cada vegada que reben un correu, un tweet, un missatge a Facebook... lo que fa que la gent estigui sempre assabentada de tot en qualsevol lloc i moment. El objetivo de este proyecto es ...

Atròfia muscular espinal: mecanismes patogènics i estratègies terapèutiques en models murins de la malaltia

OpenAIRE

Cerveró Cebrià, Clàudia

2016-01-01

L’atròfia muscular espinal (AME) és una malaltia genètica que cursa amb mort de motoneurones espinals i atròfia muscular. S’ha caracteritzat un model murí d’AME, l’Smn2B/-, amb una clínica menys severa que la mostrada per altres models més extensament utilitzats. S’ha evidenciat una alteració multisistèmica acompanyant a la clàssicament coneguda del sistema neuromuscular. S’han estudiat les sinapsis colinèrgiques tipus C en l’AME i testat el paper del PRE-084 (agonista del receptor sigm...

Sostenibilitat, participació i educació: les concepcions del món i de la tecnociència en la transformació dels conflictes socioambientals. Una aproximació metodològica per al desenvolupament de capacitats de sostenibilitat activa des de l'aprenentatge de la tecnologia

OpenAIRE

Lobera Serrano, Josep A.

2010-01-01

L'ésser humà sempre ha estat en contínua interacció amb el seu medi, una interacció que no ha estat exempta de tensions. Des de l'antiguitat diversos registres mostren en diverses societats la consciència de la interdependència entre les societats humanes i el medi natural en què es troben, que habitualment es tradueix en un interès pragmàtic per conservar l'entorn de què depenen per a la seva supervivència. En el moment actual, aquestes interaccions de les societats humanes amb el seu ambien...

Interannual nest reuse by Redshank (Tringa totanus)

OpenAIRE

Bertolero, Albert

2002-01-01

Es descriu per primera vegada la reutilització interanual de nius en la gamba roja. Dels vuit nius dels quals es va poder comprovar la situació en anys successius, en quatre es va constatar que van eclosionar amb èxit i que van ser reutilitzats l'any següent. Dels nius no reutilitzats, un no va eclosionar amb èxit, mentre que es desconeix el resultat dels altres tres. Com que els adults no es van marcar, no es pot assegurar si són les mateixes parelles les que reutilitzen els nius en anys con...

El papel de la monarquía en la Inglaterra del siglo XVIII

OpenAIRE

Black, Jeremy

2005-01-01

En aquest article, Black es planteja una nova visió del paper de la monarquia anglesa per acabar amb la idea d’excepcionalitat britànica basada en una monarquia parlamentària com a fil conductor de la història anglesa. Aquest estudi es focalitza en el segle XVIII, sobre el qual hi ha poques investigacions destinades a conèixer el paper de la monarquia britànica. L’autor compara la situació anglesa amb la circumstància política que es vivia en l’àmbit europeu i mundial del moment, tot destacan...

Eliminació d'Acid Yellow 25 i Acid Blue 92 mitjançant el mètode de la coagulació - floculació

OpenAIRE

Murcia Comas, Rosa

2008-01-01

La indústria tèxtil genera cada any milers de tones d’efluents residuals amb components colorants procedents del propi procés de tintat. Per tal d’evitar abocaments d’aquests residus al riu o mar, és necessari tractar aquests efluents per tal d’eliminar al màxim les substàncies colorants que contenen. Actualment hi ha moltes tècniques per al tractament d’aigües, des de la biodegradació, la fotodescomposició, la nanofiltració i moltes més, però aquestes són tècniques amb un alt ...

Prevalença i perfil sociodemogràfic del maltractament psíquic, físic i sexual en les pacients d’urgències a la regió de Múrcia

OpenAIRE

González Morga, Natalia; García Guillamón, Glória; Brando Asensio, Immaculada

2014-01-01

La violència de gènere és un fenomen parcialment visible en la societat del segle XXI. Amb aquest estudi es pretén determinar la prevalença de violència de gènere en dones que van a urgències per altres patologies i relacionar la presència del maltractament psicològic, físic i sexual amb diferents variables sociodemogràfiques per establir el perfil de la dona víctima del maltractament encobert en l’escenari estudiat. Per fer-ho, 151 dones, pacients de l’Hospital General Universitari Morales M...

Pacientes con fractura de cadera. Valoración de la cirugía precoz en estados de antiagregación plaquetaria

OpenAIRE

Mas i Atance, Jaume

2014-01-01

El tractament estàndard de la fractura de maluc és la cirurgia precoç sota anestèsia raquídia . S'ha descrit un augment de les complicacions quan el tractament es posposa més enllà de les 48 hores, sigui quin sigui el motiu de la demora . El maneig dels pacients amb fractura de maluc que a més es troben en tractament amb antiagregants plaquetaris ha generat controvèrsia, perquè en limitar la possibilitat d'una anestèsia regional, es tendeix a demorar la intervenció per evitar el risc d'una...

Diferències pronòstiques en les pancreatitis agudes greus d'origen biliar i enòlic

OpenAIRE

Farré i Font, Roser

2012-01-01

Introducció: Les Pancreatitis Agudes (PA) es diagnostiquen amb dos dels tres criteris d'Atlanta: dolor abdominal, elevació d'amilases tres vegades per sobre del valor alt de la normalitat i TAC diagnòstic de PA. L'etiologia més prevalent en el nostre medi és la biliar (40-60%) seguit de l'alcohòlica (10-25%). Un 80% dels casos tenen un curs lleu amb reintroducció de la dieta i alta precoç mentre que un 20% són greus i requereixen tractament intensiu multidisciplinar. En el grup de PAG (pancre...

Influencia de los valores y las orientaciones motivacionales del entrenador sobre el compromiso en la práctica deportiva de nadadores con discapacidad física

OpenAIRE

Arévalo Navinés, Maria Ángeles

2017-01-01

En el present estudi es pretén avaluar la relació entre els valors, l'orientació motivacional, els motius i el compromís de l'entrenador i del nedador per practicar la natació. S'analitzen aquestes relacions per establir possibles valors i motivacions que influeixen en el compromís que el nedador amb discapacitat física federat estableix amb la pràctica d'aquest esport. Per a això s'estudien 77 nedadors i 23 entrenadors de 21 clubs de natació de territori català i espanyol, mitjançant l'a...

Motion analysis in terms of wireless video capsule endoscopy

OpenAIRE

Autengruber, Markus

2009-01-01

El treball presentat suposa una visió general de l'"Endoscopia amb Càpsula de Vídeo Wireless" i la inspecció de sequències de contraccions intestinals amb les últimes tecnologies de visió per computador. Després de la observació preliminar dels fonaments mèdics requerits, la aplicació de visió per computador es presenta en aquestos termes. En essència, aquest treball proveïx una exhaustiva selecció, descripció i avaluació de cert conjunt de mètodes de processament d'imatges respecte a l'anàli...

Passaport a la professió en el Grau de Farmàcia

Directory of Open Access Journals (Sweden)

Carmen Escolano Mirón

2014-12-01

Full Text Available La incorporació del sistema universitari espanyol al Espai Europeu d’Educació Superior (EEES ha implicat una sèrie d’adaptacions dels graus. Entre aquests s’ha de destacar un període de pràctiques externes a la pròpia universitat, lo que ha comportar una sèrie de canvis considerables en els plans d’estudis de manera que s’aconsegueixi un balanç més equilibrat entre la formació teòrica i pràctica rebuda pels estudiants. Aquest nou marc de treball ha estat confirmat legalment pel Govern espanyol (Real Decreto 1393/2007, de 20 d’octubre i Real Decreto 1707/2011 de 18 de novembre i en el cas de la Universitat de Barcelona amb la publicació d’una normativa de pràctiques (Normativa de pràctiques acadèmiques externes dels estudiants de la Universitat de Barcelona. Aprofitant aquesta oportunitat per adaptar el Grau de Farmàcia a la realitat social actual, l’equip deganal de la Facultat de Farmàcia amb el recolzament del personal administratiu i el Servei d’atenció a l’estudiant, va assumir el repte d’incloure una nova assignatura en el pla docent del Grau de Farmàcia, que es va denominar “Pràctiques en empreses”. En paral·lel a la posta en marxa d’aquesta assignatura, es va iniciar una nova activitat per assegurar que els estudiants escollirien adequadament la companyia/departament/lloc de treball i donar-los les nocions bàsiques per poder afrontar amb les millors garanties d’èxit l’entrevista laboral. Sota el nom “Passaport a la professió”, s’han programat una sèrie de deu sessions per cada any acadèmic. Aquestes sessions inclouen temes d’una amplia varietat per proveir als estudiants amb les eines bàsiques per aprofitar al màxim el període de practiques i afrontar amb èxit el seu futur professional quan acabin els estudis de grau. A més, s’han celebrat tres workshops i dos taules rodones per apropar el mon de l’empresa a la universitat. S’ha de destacar que el projecte s�

Prototype muon detectors for the AMIGA component of the Pierre Auger Observatory

Czech Academy of Sciences Publication Activity Database

Aab, A.; Abreu, P.; Aglietta, M.; Blažek, Jiří; Boháčová, Martina; Chudoba, Jiří; Ebr, Jan; Mandát, Dušan; Nečesal, Petr; Palatka, Miroslav; Pech, Miroslav; Prouza, Michael; Řídký, Jan; Schovánek, Petr; Trávníček, Petr; Vícha, Jakub

2016-01-01

Roč. 11, Feb (2016), 1-27, č. článku P02012. ISSN 1748-0221 R&D Projects: GA MŠk(CZ) LG13007; GA MŠk(CZ) 7AMB14AR005; GA ČR(CZ) GA14-17501S Institutional support: RVO:68378271 Keywords : detector design and construction technologies and materials * particle detectors * overall mechanics design Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.220, year: 2016

Search for correlations between the arrival directions of IceCube neutrino events and ultrahigh-energy cosmic rays detected by the Pierre Auger Observatory and the Telescope Array

Czech Academy of Sciences Publication Activity Database

Aartsen, M.G.; Abraham, K.; Ackermann, M.; Blažek, Jiří; Boháčová, Martina; Chudoba, Jiří; Ebr, Jan; Mandát, Dušan; Nečesal, Petr; Palatka, Miroslav; Pech, Miroslav; Prouza, Michael; Řídký, Jan; Schovánek, Petr; Trávníček, Petr; Vícha, Jakub

2016-01-01

Roč. 1, Jan (2016), 1-34, č. článku 037. ISSN 1475-7516 R&D Projects: GA MŠk(CZ) LG13007; GA MŠk(CZ) 7AMB14AR005; GA ČR(CZ) GA14-17501S Institutional support: RVO:68378271 Keywords : neutrino experiments * ultra high energy cosmic rays * cosmic ray experiments * neutrino astronomy Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 4.734, year: 2016

Optimization of the Critical Parameters of the Spherical Agglomeration Crystallization Method by the Application of the Quality by Design Approach

Directory of Open Access Journals (Sweden)

Orsolya Gyulai

2018-04-01

Full Text Available This research work presents the use of the Quality by Design (QbD concept for optimization of the spherical agglomeration crystallization method in the case of the active agent, ambroxol hydrochloride (AMB HCl. AMB HCl spherical crystals were formulated by the spherical agglomeration method, which was applied as an antisolvent technique. Spherical crystals have good flowing properties, which makes the direct compression tableting method applicable. This means that the amount of additives used can be reduced and smaller tablets can be formed. For the risk assessment, LeanQbD Software was used. According to its results, four independent variables (mixing type and time, dT (temperature difference between solvent and antisolvent, and composition (solvent/antisolvent volume ratio and three dependent variables (mean particle size, aspect ratio, and roundness were selected. Based on these, a 2–3 mixed-level factorial design was constructed, crystallization was accomplished, and the results were evaluated using Statistica for Windows 13 program. Product assay was performed and it was revealed that improvements in the mean particle size (from ~13 to ~200 µm, roundness (from ~2.4 to ~1.5, aspect ratio (from ~1.7 to ~1.4, and flow properties were observed while polymorphic transitions were avoided.

Optimization of the Critical Parameters of the Spherical Agglomeration Crystallization Method by the Application of the Quality by Design Approach.

Science.gov (United States)

Gyulai, Orsolya; Kovács, Anita; Sovány, Tamás; Csóka, Ildikó; Aigner, Zoltán

2018-04-20

This research work presents the use of the Quality by Design (QbD) concept for optimization of the spherical agglomeration crystallization method in the case of the active agent, ambroxol hydrochloride (AMB HCl). AMB HCl spherical crystals were formulated by the spherical agglomeration method, which was applied as an antisolvent technique. Spherical crystals have good flowing properties, which makes the direct compression tableting method applicable. This means that the amount of additives used can be reduced and smaller tablets can be formed. For the risk assessment, LeanQbD Software was used. According to its results, four independent variables (mixing type and time, dT (temperature difference between solvent and antisolvent), and composition (solvent/antisolvent volume ratio)) and three dependent variables (mean particle size, aspect ratio, and roundness) were selected. Based on these, a 2⁻3 mixed-level factorial design was constructed, crystallization was accomplished, and the results were evaluated using Statistica for Windows 13 program. Product assay was performed and it was revealed that improvements in the mean particle size (from ~13 to ~200 µm), roundness (from ~2.4 to ~1.5), aspect ratio (from ~1.7 to ~1.4), and flow properties were observed while polymorphic transitions were avoided.

The Surface and Bulk Magnetic Properties of Fe-Al Alloys

Czech Academy of Sciences Publication Activity Database

Hendrych, A.; Žitovsky, O.; Jirásková, Yvonna; Matko, I.

2014-01-01

Roč. 126, č. 1 (2014), s. 58-59 ISSN 0587-4246. [CSMAG Czech and Slovak Conference on Magnetism /15./. Košice, 17.06.2013-21.06.2013] R&D Projects: GA MŠk 7AMB12SK009 Institutional support: RVO:68081723 Keywords : Fe-Al * MOKE * Surface properties * MFM Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.530, year: 2014

Depth of maximum of air-shower profiles at the Pierre Auger Observatory. II. Composition implications

Czech Academy of Sciences Publication Activity Database

Aab, A.; Abreu, P.; Aglietta, M.; Boháčová, Martina; Chudoba, Jiří; Ebr, Jan; Mandát, Dušan; Nečesal, Petr; Palatka, Miroslav; Pech, Miroslav; Prouza, Michael; Řídký, Jan; Schovánek, Petr; Trávníček, Petr; Vícha, Jakub

2014-01-01

Roč. 90, č. 12 (2014), "122006-1"-"122006-12" ISSN 1550-7998 R&D Projects: GA MŠk(CZ) LG13007; GA MŠk(CZ) 7AMB14AR005; GA ČR(CZ) GA14-17501S Institutional support: RVO:68378271 Keywords : Pierre Auger Observatory * air- shower * fluorescence telescopes Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 4.643, year: 2014

Improved limit to the diffuse flux of ultrahigh energy neutrinos from the Pierre Auger Observatory

Czech Academy of Sciences Publication Activity Database

Aab, A.; Abreu, P.; Aglietta, M.; Boháčová, Martina; Chudoba, Jiří; Ebr, Jan; Mandát, Dušan; Nečesal, Petr; Palatka, Miroslav; Pech, Miroslav; Prouza, Michael; Řídký, Jan; Schovánek, Petr; Trávníček, Petr; Vícha, Jakub

2015-01-01

Roč. 91, č. 9 (2015), "092008-1"-"092008-14" ISSN 1550-7998 R&D Projects: GA MŠk(CZ) LG13007; GA MŠk(CZ) 7AMB14AR005; GA ČR(CZ) GA14-17501S Institutional support: RVO:68378271 Keywords : cosmic rays * Pierre Auger * ultrahigh energy * surface detector Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 4.643, year: 2014

The Cyrillo-Methodian tradition in the work of Milada Paulová as a historical discourse

Czech Academy of Sciences Publication Activity Database

Havlíková, Lubomíra

2013-01-01

Roč. 71, 1-2 (2013), s. 31-46 ISSN 0007-7712 R&D Projects: GA MŠk 7AMB12SK161 Institutional support: RVO:68378017 Keywords : Byzantium * Byzantine studies * history * historiography * Constantine-Cyrillus * Methodius * Cyrilo-Methodian tradition * Great Moravia * Milada Paulová (1897-1970) * Cyrillo-Methodian anniversary * Emmaus Monastery * Emperor Charles IV * 14th century * Byzantine-Slav relations Subject RIV: AB - History

Instrumentation for comparing night sky quality and atmospheric conditions of CTA site candidates

Czech Academy of Sciences Publication Activity Database

Fruck, C.; Gaug, M.; Ernenwein, J.-P.; Mandát, Dušan; Schweizer, T.; Häfner, D.; Bulik, T.; Cieslar, M.; Costantini, H.; Dominik, M.; Ebr, Jan; Garczarczyk, M.; Lorentz, E.; Pareschi, I.; Pech, Miroslav; Puerto-Giménez, I.; Teshima, M.

2015-01-01

Roč. 10, Apr (2015), P04012 ISSN 1748-0221 R&D Projects: GA MŠk(CZ) 7AMB12AR013; GA MŠk LE13012; GA MŠk LG14019 Institutional support: RVO:68378271 Keywords : large detector systems for particle and astroparticle physics * gamma telescopes * instrument optimisation * gamma detectors Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.310, year: 2015

Selection of astrophysical/astronomical/solar sites at the Argentina East Andes range taking into account atmospheric components

Czech Academy of Sciences Publication Activity Database

Piacentini, R.D.; García, B.; Micheletti, M.I.; Salum, G.; Freire, M.; Maya, J.; Mancilla, A.; Crinó, E.; Mandát, Dušan; Pech, M.; Bulik, T.

2016-01-01

Roč. 57, č. 12 (2016), s. 2559-2574 ISSN 0273-1177 R&D Projects: GA MŠk(CZ) 7AMB14AR005; GA MŠk LE13012; GA MŠk LG14019; GA MŠk LM2015046 Institutional support: RVO:68378271 Keywords : astrophysical * astronomical * solar: sites * Argentina -Andes: atmospheric components Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 1.401, year: 2016

Effect of chiral photosensitive liquid crystalline dopants on theperformance of organic solar cells

Czech Academy of Sciences Publication Activity Database

Iwan, A.; Boharewicz, B.; Tazbir, I.; Hamplová, Věra; Bubnov, Alexej

2015-01-01

Roč. 104, Feb (2015), s. 53-60 ISSN 0038-1101 R&D Projects: GA MŠk 7AMB13PL041; GA ČR GA13-14133S; GA MŠk(CZ) LD14007 Grant - others:AVČR(CZ) M100101204 Institutional support: RVO:68378271 Keywords : organic solar cell * composite with liquid crystal Subject RIV: CG - Electrochemistry Impact factor: 1.345, year: 2015

Pleiotropic preconditioning-like cardioprotective effects of hypolipidemic drugs in acute ischemia–reperfusion in normal and hypertensive rats

Czech Academy of Sciences Publication Activity Database

Ravingerová, T.; Ledvényiová-Farkašová, V.; Ferko, M.; Barteková, M.; Bernátová, I.; Pecháňová, O.; Adameová, A.; Kolář, František; Lazou, A.

2015-01-01

Roč. 93, č. 7 (2015), s. 495-503 ISSN 0008-4212 R&D Projects: GA MŠk(CZ) 7AMB14SK115 Grant - others:AV ČR(CZ) SAV-15-15 Program:Bilaterální spolupráce Institutional support: RVO:67985823 Keywords : myocardial ischemia * cardioprotection * hypolipidemic drugs Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 1.704, year: 2015

The Ascoli property for function spaces

Czech Academy of Sciences Publication Activity Database

Gabriyelyan, S.; Grebík, Jan; Kąkol, Jerzy; Zdomskyy, L.

2016-01-01

Roč. 214, 1 December (2016), s. 35-50 ISSN 0166-8641 R&D Projects: GA ČR(CZ) GF15-34700L; GA ČR GF16-34860L; GA MŠk(CZ) 7AMB15AT035 Institutional support: RVO:67985840 Keywords : ascoli * paracompact * scattered Subject RIV: BA - General Mathematics Impact factor: 0.377, year: 2016 http://www.sciencedirect.com/science/article/pii/S0166864116302152

A review of the methods for neuronal response latency estimation

Czech Academy of Sciences Publication Activity Database

Leváková, Marie; Tamborrino, M.; Ditlevsen, S.; Lánský, Petr

2015-01-01

Roč. 136, Oct 2015 (2015), s. 23-34 ISSN 0303-2647 R&D Projects: GA ČR(CZ) GA15-08066S; GA MŠk 7AMB15AT010 Institutional support: RVO:67985823 Keywords : change point analysis * evoked activity * maximum likelihood estimation * Bayesian analysis * spike trains * extracellular recordings in neurons Subject RIV: BD - Theory of Information Impact factor: 1.495, year: 2015

El silencio de los Homeless. Ciencia de la marginalidad y segregación discursiva de los sin techo

Directory of Open Access Journals (Sweden)

Walter Baroni

2013-03-01

Full Text Available L’article examina les formes de categorització cognitiva amb les que els professionals dels serveis socials es refereixen als sense sostre. A aquests efectes, es pren en consideració i s’analitza material d’investigació recopilat en un estudi etnogràfic realitzat a Gènova en relació amb els serveis socials que ofereixen assistència als sense sostre. Es consideren les definicions sobre la condició sense sostre dels treballadors locals del tercer sector, juntament amb l’European Typology of Homelessness and Housing Exclusión (ETHOS- una classificació de la condició sense sostre de referència a nivell europeu -, per entendre com es relacionen les dues tipologies, i si estan produïdes per el mateix mecanisme lingüístic. L’anàlisi també es centra en la representació dels sense sostre que es pot veure a la revista de carrer més important d’Itàlia, Scarp de’tenis [Sabatilla de tenis], que expressa el punt de vista catòlic sobre la pobresa i la condició sense sostre. Amb la mateixa finalitat, s’ha considerat igualment la forma de narrar la vida d’una parella sense sostre a La Bocca del Lupo [La boa del llop], un documental premiat a festivals internacionals, que ha estat produït i gravat a Gènova. L’objectiu és mostrar com el sentit comú professional, recolzat per un sostén científic, produeix un discurs paradoxal sobre la condició sense sostre. Es considera que els sense sostre presenten mancances morals, cognitives i lingüístiques; no obstant, per ser reeducats d’acord amb els estàndards socials han de mostrar les capacitats que es suposa que no posseeixen. Tots els textos objecte d’examen, des de les entrevistes dels treballadors socials al documental, es poden veure com efectes discursius d’aquesta paradoxa, que els intenten fer funcionar sense èxit. El que aconsegueixen és, en canvi, confinar encara més als sense sostre a la gàbia de les seves incapacitats, impossibilitant que s�

Synergy and antagonism between iron chelators and antifungal drugs in Cryptococcus.

Science.gov (United States)

Lai, Yu-Wen; Campbell, Leona T; Wilkins, Marc R; Pang, Chi Nam Ignatius; Chen, Sharon; Carter, Dee A

2016-10-01

Fungal infections remain very difficult to treat, and developing new antifungal drugs is difficult and expensive. Recent approaches therefore seek to augment existing antifungals with synergistic agents that can lower the therapeutic dose, increase efficacy and prevent resistance from developing. Iron limitation can inhibit microbial growth, and iron chelators have been employed to treat fungal infections. In this study, chequerboard testing was used to explore combinations of iron chelators with antifungal agents against pathogenic Cryptococcus spp. with the aim of determining how disruption to iron homeostasis affects antifungal susceptibility. The iron chelators ethylenediaminetetraacetic acid (EDTA), deferoxamine (DFO), deferiprone (DFP), deferasirox (DSX), ciclopirox olamine and lactoferrin (LF) were paired with the antifungal agents amphotericin B (AmB), fluconazole, itraconazole, voriconazole and caspofungin. All chelators except for DFO increased the efficacy of AmB, and significant synergy was seen between AmB and LF for all Cryptococcus strains. Addition of exogenous iron rescued cells from the antifungal effect of LF alone but could not prevent inhibition by AmB + LF, indicating that synergy was not due primarily to iron chelation but to other properties of LF that were potentiated in the presence of AmB. Significant synergy was not seen consistently for other antifungal-chelator combinations, and EDTA, DSX and DFP antagonised the activity of azole drugs in strains of Cryptococcus neoformans var. grubii. This study highlights the range of interactions that can be induced by chelators and indicates that most antifungal drugs are not enhanced by iron limitation in Cryptococcus. Copyright © 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Research on dynamics and experiments about auxiliary bearings for the helium circulator of the 10 MW high temperature gas-cooled reactor

International Nuclear Information System (INIS)

Zhao, Yulan; Yang, Guojun; Liu, Xingnan; Shi, Zhengang; Zhao, Lei

2016-01-01

Highlights: • The research in this paper is based on the AMB helium circulator of HTR-10. • The dynamic rotor performance is analyzed by processing experimental data. • The mechanical bearing without lubrication can be applied in the HTR-10 system. - Abstract: The 10 MW high-temperature gas-cooled reactor (HTR-10) was constructed by the Institute of Nuclear and New Energy Technology (INET) of Tsinghua University. The auxiliary bearing is utilized in this system to meet particular requirements for the reactor. The main role of the auxiliary bearing is to constrain rotor displacements and also to support the rotor when the rotor drops down, which is caused by the active magnetic bearing (AMB) failure. The auxiliary bearing needs to endure huge impact, rapid angular acceleration and thermal shock. On the one hand, complex geometrical constructions and forces applied on the system bring difficulties and restrictions to establish an appropriate model to reveal the actual dynamic process. On the other hand, large volumes of data obtained from experiments show velocities and displacements of the rotor during the rotor drop process and then can indicate the actual dynamic interactions to a great extent. The research in this paper is based on the test rig of the AMB helium circulator of HTR-10. This paper aims to analyze the dynamic performance and contact forces of the rotor by processing experimental data. A measurement to estimate forces developed due to impacts of the rotor and the auxiliary bearings is presented. It is of great significance and provides certain foundation to elaborate the rotor drop process for the AMB helium circulator of HTR-10.

Els «criteris de visibilització de les dones» en català: límits sintacticosemàntics i discursius

Directory of Open Access Journals (Sweden)

Neus Nogué Serrano

2013-07-01

Full Text Available L’objectiu d’aquest article és analitzar els principals criteris que les guies d’estil recomanen per a visibilitzar les dones —o per fer un ús no sexista del llenguatge— des de dos punts de vista: el sintacticosemàntic i el discursiu. Des del punt de vista sintacticosemàntic, s’estudien bàsicament els fenòmens relacionats amb la coordinació, la concordança i la repetició o elisió d’elements (per exemple, especificadors del nom, i la manera com les diferents opcions afecten el significat oracional. Des del punt de vista discursiu, s’analitzen els fenòmens relacionats amb la coreferència; és a dir, la relació entre les diferents maneres d’expressar un mateix referent per mitjà d’elements nominals al llarg del text, i l’efecte que provoquen en el text en conjunt. Amb aquest objectiu, l’estudi analitza des d’un punt de vista qualitatiu les dades proporcionades per un corpus de textos procedents de tres àmbits (polític, administratiu i educatiu en què s’apliquen sovint aquesta mena de criteris.

La comprensió de les clàusules de relatiu en català infantil

Directory of Open Access Journals (Sweden)

Anna Gavarró

2013-07-01

Full Text Available Les clàusules de relatiu han estat objecte d’un nombre important de treballs en el camp de la gramàtica adulta, la gramàtica infantil i l’afàsia. Aquí emprenen el primer estudi de la comprensió de les clàusules de relatiu de subjecte i d’objecte en català infantil. Repliquem un experiment dissenyat per a l’italià per Adani (2008, en concret una tasca d’identificació d’agent, amb 33 nens parlants del català central d’edats compreses entre els 3,5 i els 6,2 anys. L’anàlisi dels resultats indica que els nens assoleixen nivells adults de comprensió de les relatives de subjecte primerencament, mentre que la comprensió de les relatives d’objecte progressa però no assoleix nivells adults fins a l’edat de 5,6 anys. Les relatives d’objecte amb subjecte postverbal majoritàriament s’interpreten de forma errònia com a relatives de subjecte per a tots els grups examinats, en clar contrast amb el comportament adult.

Transcriptional profiling of Bordetella pertussis reveals requirement of RNA chaperone Hfq for Type III secretion system functionality

Czech Academy of Sciences Publication Activity Database

Bíbová, Ilona; Hot, D.; Keidel, Kristina; Amman, F.; Slupek, S.; Černý, Ondřej; Gross, R.; Večerek, Branislav

2015-01-01

Roč. 12, č. 2 (2015), s. 175-185 ISSN 1547-6286 R&D Projects: GA ČR(CZ) GAP302/11/1940; GA MŠk(CZ) EE2.3.20.0055; GA MŠk(CZ) EE2.3.30.0003; GA MŠk(CZ) 7AMB14AR028; GA MŠk(CZ) ED1.1.00/02.0109 Institutional support: RVO:61388971 Keywords : Bsp22 * Hfq * infection Subject RIV: CE - Biochemistry Impact factor: 4.076, year: 2015

Nanosecond-level time synchronization of autonomous radio detector stations for extensive air showers

Czech Academy of Sciences Publication Activity Database

Aab, A.; Abreu, P.; Aglietta, M.; Boháčová, Martina; Chudoba, Jiří; Ebr, Jan; Mandát, Dušan; Nečesal, Petr; Palatka, Miroslav; Pech, Miroslav; Prouza, Michael; Řídký, Jan; Schovánek, Petr; Trávníček, Petr; Vícha, Jakub

2016-01-01

Roč. 11, Jan (2016), 1-31, č. článku P01018. ISSN 1748-0221 R&D Projects: GA MŠk(CZ) LG13007; GA MŠk(CZ) 7AMB14AR005; GA ČR(CZ) GA14-17501S Institutional support: RVO:68378271 Keywords : pattern recognition * cluster finding * calibration and fitting methods * timing detectors * detector alignment and calibration methods Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.220, year: 2016

Computational modeling of magnetic hysteresis with thermal effects

Czech Academy of Sciences Publication Activity Database

Kružík, Martin; Valdman, Jan

2018-01-01

Roč. 145, č. 1 (2018), s. 90-105 ISSN 0378-4754 R&D Projects: GA ČR GA13-18652S; GA ČR(CZ) GF16-34894L; GA ČR(CZ) GA17-04301S; GA MŠk(CZ) 7AMB16AT015 Institutional support: RVO:67985556 Keywords : Dissipative processes * hysteresis * micromagnetics Subject RIV: BA - General Mathematics Impact factor: 1.218, year: 2016 http://library.utia.cas.cz/separaty/2017/MTR/kruzik-0474872.pdf

Disseny d'una microxarxa amb generació renovable

OpenAIRE

Durich Serra, Ruben

2016-01-01

El present projecte pretén abordar l’estudi dels costs de generació d’energia elèctrica renovable de la tecnologia solar-fotovoltaica per tal de formar part del disseny d’una microxarxa de generació d’energia elèctrica. Durant la realització del projecte s’ha realitzat una breu introducció a les microxarxes de distribució d’energia elèctrica i als seus reptes. Per estudiar el cost de generació d’energia fotovoltaica s’ha utilitzat la metodologia del Levelized Cost of Energy ...

L'evolució del rol dramàtic de la Bella Dorment i Malèfica a les adaptacions cinematogràfiques homònimes de 1959 i 2014

OpenAIRE

Escobar Pérez, Marina

2015-01-01

Aquest treball de recerca i investigació és el resultat d'un anàlisi qualitatiu i de gènere realitzat d'acord amb la teoria audiovisual narrativa i la teoria fílmica feminista sobre la representació cinematogràfica dels personatges de la Bella Dorment i Malèfica a les pel•lícules homònimes dels anys 1959 i 2014 amb l'objectiu de determinar l'evolució del seu rol dramàtic. Este trabajo de investigación es el resultado de un análisis cualitativo y de género realizado en base a la teoría audi...

Projecte d’un centre d’equinoteràpia al terme municipal de Camallera

OpenAIRE

Blanch Pascual, Lidia

2012-01-01

L’objectiu del projecte és la construcció d’una hípica d’equinoteràpia, eugassada de cavalls de Pura Raça Espanyola i pupil•latge al municipi de Saus, Camallera i Llampaies, de la comarca de l’Alt Empordà, província de Girona. La finca, de propietat dels promotors, és una parcel•la rural, sense construccions, amb dos pous d’aigua oberts. La classe de sòl és rústica, actualment d’ús agrari amb una superfície de 122.541 m2, repartits en pins per fusta de 2,1136 ha, arbustos de 0,...