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Sample records for magnetic proton recoil

  1. Design of magnetic analysis system for magnetic proton recoil spectrometer

    International Nuclear Information System (INIS)

    Qi Jianmin; Jiang Shilun; Zhou Lin; Peng Taiping

    2010-01-01

    Magnetic proton recoil (MPR) spectrometer is a novel diagnostic instrument with high performance for measurements of the neutron spectra from inertial confinement fusion (ICF) experiments and high power fusion devices. The design of the magnetic analysis system, which is a key part of the compact MPR-type spectrometer, has been completed through two-dimensional beam transport simulations and three-dimensional particle transport simulation. The analysis of the system's parameters and performances was performed, as well as system designs based on preferential principles of energy resolution, detection efficiency, and count rate, respectively. The results indicate that the magnetic analysis system can achieve a detection efficiency of 10 -5 ∼ 10 -4 level at the resolution range of 1.5% to 3.0% and fulfill the design goals of the compact MPR spectrometer. (authors)

  2. Calibration of a compact magnetic proton recoil neutron spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Jianfu, E-mail: zhang_jianfu@163.com [School of Nuclear Science and Technology, Xi' an Jiaotong University, Xi' an 710049 (China); Northwest Institute of Nuclear Technology, Xi' an 710024 (China); Ouyang, Xiaoping; Zhang, Xianpeng [School of Nuclear Science and Technology, Xi' an Jiaotong University, Xi' an 710049 (China); Northwest Institute of Nuclear Technology, Xi' an 710024 (China); Ruan, Jinlu [Northwest Institute of Nuclear Technology, Xi' an 710024 (China); Zhang, Guoguang [Applied Institute of Nuclear Technology, China Institute of Atomic Energy, Beijing 102413 (China); Zhang, Xiaodong [Northwest Institute of Nuclear Technology, Xi' an 710024 (China); Qiu, Suizheng, E-mail: szqiu@mail.xjtu.edu.cn [School of Nuclear Science and Technology, Xi' an Jiaotong University, Xi' an 710049 (China); Chen, Liang; Liu, Jinliang; Song, Jiwen; Liu, Linyue; Yang, Shaohua [Northwest Institute of Nuclear Technology, Xi' an 710024 (China)

    2016-04-21

    Magnetic proton recoil (MPR) neutron spectrometer is considered as a powerful instrument to measure deuterium–tritium (DT) neutron spectrum, as it is currently used in inertial confinement fusion facilities and large Tokamak devices. The energy resolution (ER) and neutron detection efficiency (NDE) are the two most important parameters to characterize a neutron spectrometer. In this work, the ER calibration for the MPR spectrometer was performed by using the HI-13 tandem accelerator at China Institute of Atomic Energy (CIAE), and the NDE calibration was performed by using the neutron generator at CIAE. The specific calibration techniques used in this work and the associated accuracies were discussed in details in this paper. The calibration results were presented along with Monte Carlo simulation results.

  3. Determination of the Jet Neutron Rate and Fusion Power using the Magnetic Proton Recoil Neutron Spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Sjoestrand, Henrik

    2003-01-01

    In this thesis a new independent method has been developed to enable precise measurements of neutron yields and rates from fusion plasmas and thereby determining the fusion power and fusion energy. The new method, together with the associated diagnostics, can provide information of great importance to present and future high fusion yield experiments, such as the Joint European Torus (JET) tokamak and the International Thermonuclear Experiment Reactor (ITER). The method has been applied to data from high fusion rate experiments from the tritium campaign at JET. By using the count-rate from the Magnetic Proton Recoil (MPR) neutron spectrometer the number of neutrons in the spectrometer's line of sight has been calculated. To be able to do this, all relevant factors between the plasma and the instrument have been evaluated. The number of neutrons in the MPR line of sight has been related to the total number of produced neutrons in the plasma by using information on the neutron emission profile. The achieved results have been compared with other JET neutron diagnostic data and the agreement is shown to be very good.

  4. The thin-foil magnetic proton recoil neutron spectrometer MPRu at JET

    International Nuclear Information System (INIS)

    Andersson Sunden, E.; Sjoestrand, H.; Conroy, S.; Ericsson, G.; Gatu Johnson, M.; Giacomelli, L.; Hellesen, C.; Hjalmarsson, A.; Ronchi, E.; Weiszflog, M.; Kaellne, J.; Gorini, G.; Tardocchi, M.; Combo, A.; Cruz, N.; Batista, A.; Pereira, R.; Fortuna, R.; Sousa, J.; Popovichev, S.

    2009-01-01

    Neutrons are produced in fusion energy experiments with both deuterium (D) and deuterium-tritium (DT) plasmas. Neutron spectroscopy is a valuable tool in the study of the underlying fuel ion populations. The magnetic proton recoil neutron spectrometer, originally installed at JET in 1996 for 14-MeV neutron measurements, has been upgraded, with the main aim of improving its signal-to-background ratio (S/B), making measurements of the 2.5-MeV neutron emission in D plasmas possible. The upgrade includes a new focal-plane detector, based on the phoswich technique and consequently less sensitive to background, and a new custom-designed digital data acquisition system based on transient recorder cards. Results from JET show that the upgraded MPRu can measure 2.5-MeV neutrons with S/B=5, an improvement by a factor of 50 compared with the original MPR. S/B of 2.8x10 4 in future DT experiments is estimated. The performance of the MPRu is exemplified with results from recent D plasma operations at JET, concerning both measurements with Ohmic, ion cyclotron resonance (ICRH) and neutral beam injection (NBI) plasma heating, as well as measurements of tritium burn-up neutrons. The upgraded instrument allows for 2.5-MeV neutron emission and deuterium ion temperature measurements in plasmas with low levels of tritium, a feature necessary for the ITER experiment.

  5. Commissioning of a proton-recoil spectrometer

    International Nuclear Information System (INIS)

    Nunes, J.C.; Faught, R.T.

    2000-01-01

    Measurements of neutron fluence spectra in fields from bare and heavy-water-moderated 252 Cf were made with a commercially available proton-recoil spectrometer (PRS) that covers 50 keV to 4.5 MeV. Data obtained from these measurements were compared with data from Bonner sphere spectrometry, Monte Carlo simulation and the open literature. Alterations to the input data file used in unfolding recoil-proton pulse-height distributions were made. Understanding the reasons for these changes and considering the effects of some of the results in an appreciation of the significance of parameters used in the unfolding. An uncertainty of 10% is estimated for values of fluence and ambient dose equivalent for the energy region covered by this PRS. (author)

  6. Recoil-proton fast-neutron counter telescope

    Energy Technology Data Exchange (ETDEWEB)

    Pavan, P.; Toniolo, D.; Zago, G.; Zannoni, R. (Padua Univ. (Italy). Ist. di Fisica); Galeazzi, G.; Bressanini, G.

    1981-12-01

    A recoil-proton neutron counter telescope is described composed of a solid-state silicon transmission detector and a NE 102 A plastic scintillator, measuring the energy loss, the energy of the recoil protons and the time of flight between the two detectors. The counter exposed to monoenergetic neutron beams of energy from 6 to 20 MeV presents a low background and a moderate energy resolution. Its absolute efficiency is calculated up to 50 MeV.

  7. Recoil-proton fast-neutron-counter telescope

    Energy Technology Data Exchange (ETDEWEB)

    Galeazzi, G.; Pavan, P.; Toniolo, D.; Zago, G.; Zannoni, R.; Bressanini, G.

    1981-01-01

    A proton-recoil neutron counter telescope is described composed of a solid state silicon transmission detector and a NE 102 A plastic scintillator, measuring the energy loss, the energy of the recoil protons and the time-of-flight between the two detectors. The counter exposed to monoenergetic neutron beams of energy from 6 to 20 MeV, presents a low background and a moderate energy resolution. Its absolute efficiency is calculated up to 50 MeV.

  8. A recoil-proton fast-neutron counter telescope

    International Nuclear Information System (INIS)

    Pavan, P.; Toniolo, D.; Zago, G.; Zannoni, R.; Galeazzi, G.; Bressanini, G.

    1981-01-01

    A recoil-proton neutron counter telescope is described composed of a solid-state silicon transmission detector and a NE 102 A plastic scintillator, measuring the energy loss, the energy of the recoil protons and the time of flight between the two detectors. The counter exposed to monoenergetic neutron beams of energy from 6 to 20 MeV presents a low background and a moderate energy resolution. Its absolute efficiency is calculated up to 50 MeV. (author)

  9. Nuclear reactions excited by recoil protons on a nuclear reactor

    International Nuclear Information System (INIS)

    Mukhammedov, S.; Khaydarov, A.; Barsukova, E.G.

    2006-01-01

    The nuclear reactions excited by recoil protons and of the detection possibility of the various chemical elements with the use of these secondary nucleus reactions were investigated. The recoil protons are produced on a nuclear reactor in the result of (n, p) inelastic and elastic scattering interaction of fast neutrons with nuclei of hydrogen. It is well known that the share of fast neutrons in energetic spectrum of reactor's neutrons in comparison with the share of thermal neutrons is small. . Consequently, the share of recoil protons produced in the result of fast neutron interaction with nuclei of light elements, capable to cause the nuclear reactions, is also small, des, due to Coulomb barrier of nuclei the recoil protons can cause the nuclear reactions only on nuclei of light and some middle elements. Our studies show that observable yields have radio nuclides excited in the result of nuclear reactions on Li, B, O, V and Cu. Our experimental results have demonstrated that the proton activation analysis based on the application of secondary nuclear reactions is useful technique to determine large contents of various light and medium chemical elements. Detection limits for studied chemical elements are estimated better than 10 ppm

  10. The recoil proton polarization in πp elastic scattering

    International Nuclear Information System (INIS)

    Seftor, C.J.

    1988-09-01

    The polarization of the recoil proton for π + p and π - p elastic scattering has been measured for various angles at 547 MeV/c and 625 MeV/c by a collaboration involving The George Washington University; the University of California, Los Angeles; and Abilene Christian University. The experiment was performed at the P 3 East experimental area of the Los Alamos Meson Physics Facility. Beam intensities varied from 0.4 to 1.0 x 10 7 π - 's/sec and from 3.0 to 10.0 x 10 7 π + 's/sec. The beam spot size at the target was 1 cm in the horizontal direction by 2.5 cm in the vertical direction. A liquid-hydrogen target was used in a flask 5.7 cm in diameter and 10 cm high. The scattered pion and recoil proton were detected in coincidence using the Large Acceptance Spectrometer (LAS) to detect and momentum analyze the pions and the JANUS recoil proton polarimeter to detect and measure the polarization of the protons. Results from this experiment are compared with previous measurements of the polarization, with analyzing power data previously taken by this group, and to partial-wave analysis predictions. 12 refs., 53 figs., 18 tabs

  11. Calculations of Total and Differential Solid Angles for a Proton Recoil Solid State Detector

    Energy Technology Data Exchange (ETDEWEB)

    Konijn, J; Lauber, A; Tollander, B

    1963-08-15

    The solid angles have been computed for a proton recoil counter consisting of a circular hydrogenous foil viewed by an isotropic neutron point source at different distances from the target foil. Tables are given for the total subtended solid angle as well as the differential energy distribution function of the proton recoil spectrum. The influence of finite foil thickness has also been studied.

  12. Proton-recoil proportional counter tests at TREAT

    International Nuclear Information System (INIS)

    Fink, C.L.; Eichholz, J.J.; Burrows, D.R.; DeVolpi, A.

    1979-01-01

    A methane filled proton-recoil proportional counter will be used as a fission neutron detector in the fast-neutron hodoscope. To provide meaningful fuel-motion information the proportional counter should have: a linear response over a wide range of reactor powers background ratio (the number of high energy neutrons detected must be maximized relative to low energy neutrons, and gamma ray sensitivity must be kept small); and a detector efficiency for fission neutrons above 1 MeV of approximately 1%. In addition, it is desirable that the detector and the associated amplifier/discriminator be capable of operating at counting rates in excess of 500 kHz. This paper reports on tests that were conducted on several proportional counters at the TREAT reactor

  13. Electric form factor of the proton through recoil polarization

    International Nuclear Information System (INIS)

    Punjabi, V.

    2000-01-01

    The electromagnetic form factors of the nucleon, G E and G M , describe the charge and current distribution inside the nucleon and thus are quite intimately related to its structure. Jefferson Lab experiment 93-027 measured P l and Pt, the longitudinal and transverse recoil proton polarization, respectively, for the 1 H(e-vector,e'p-vector) reaction in the four-momentum transfer squared range of 0.5 to 3.5 GeV 2 , using the Hall A facility with two high resolution spectrometers and a Focal Plane Polarimeter. The ratio G Ep /G Mp is directly proportional to the ratio P t /P l . These data have unprecedented precision, and show for the first time that the Q 2 dependence of G Ep and G Mp is very different. (author)

  14. Proceedings of the symposium on measurements of neutron energy spectra using recoil proton proportional counters

    International Nuclear Information System (INIS)

    Urabe, Itsumasa

    1986-01-01

    This is a report of the symposium on measurements of neutron energy spectra using recoil proton proportional counters held at the Research Reactor Institute of Kyoto University on January 27 in 1986. An energy resolution, wall effects of response functions, n · γ discrimination methods and other fundamental properties of recoil proton counters are discussed for a new development of an application of this counter. (author)

  15. Probing the structure of unstable nuclei through the recoiled proton tagged knockout reaction

    International Nuclear Information System (INIS)

    Ye, Y.; Cao, Z.; Jiang, D.

    2010-01-01

    Recoiled proton tagged knockout reaction experiments were carried-out for 8 He at 82,5 MeV/u in RIKEN and for 6 He at 65 MeV/u in Lanzhou. The very preliminary results for the distinguish of the reaction mechanism are presented and compared to the kinematics calculation. (authors)

  16. Development of a digital trigger system to identify recoil protons at COMPASS-II

    Energy Technology Data Exchange (ETDEWEB)

    Buechele, Maximilian; Fischer, Horst; Gorzellik, Matthias; Grussenmeyer, Tobias; Herrmann, Florian; Joerg, Philipp; Koenigsmann, Kay; Kremser, Paul; Schopferer, Sebastian [Albert-Ludwigs-Universitaet Freiburg (Germany)

    2014-07-01

    The GANDALF framework has been developed to deliver a high precision, high performance detector readout and trigger system for particle physics experiments such as the COMPASS-II experiment at CERN. Combining the high performance pulse digitization and feature extraction capabilities of twelve GANDALF modules, each comprising a Virtex-5 SX95T, with the strong computation power of a Virtex-6 SX315T FGPA operated on the TIGER module, we present a digital trigger system for a recoil proton detector. The trigger system was setup and commissioned successfully during a data taking period in 2012. It was mainly used for the calibration of the recoil proton detector and in tagging mode to identify proton tracks online.

  17. Recoil-proton polarization in πp elastic scattering at 547 and 625 MeV/c

    International Nuclear Information System (INIS)

    Seftor, C.J.; Adrian, S.D.; Briscoe, W.J.; Mokhtari, A.; Taragin, M.F.; Sadler, M.E.; Barlow, D.B.; Nefkens, B.M.K.; Pillai, C.

    1989-01-01

    The polarization of the recoil proton in π + p and π - p elastic scattering using a liquid-hydrogen target has been measured for backward angles at 547 and 625 MeV/c. The scattered pion and recoil proton were detected in coincidence using the large-acceptance spectrometer to detect and analyze the momentum of the pions and the JANUS polarimeter to identify and measure the polarization of the protons. Results from this experiment agree with other measurements of the recoil polarization, with analyzing-power data previously taken by this group, and with predictions of partial-wave analyses

  18. Some aspects of the use of proton recoil proportional counters for fast neutron personnel dosimeters

    International Nuclear Information System (INIS)

    Yule, T.J.; Bennett, E.F.

    1984-01-01

    Gas-filled proton recoil proportional counters have been used extensively for the measurement of neutron spectra in degraded fission-spectrum environments. Some considerations relating to the use of these counters for personnel dosimetry are here described. High sensitivity and good accuracy in the determination of dose-equivalent can be obtained if relatively high pressure hydrogen-filled proportional counters are used as the active element in a dosimeter system

  19. Measurement of recoil photon polarisation in the electron-proton elastic scattering

    International Nuclear Information System (INIS)

    Buon, Jean

    1965-02-01

    This research thesis reports and discusses an experiment which aimed at checking the validity of the Born approximation at the first order in the elastic scattering of high energy electrons on protons. In this experiment, the recoil proton polarisation is measured in an elastic scattering of electrons with energy of 950 MeV and scattering at about 90 degrees in the mass centre system. The author describes the experimental installation, its operation and data collection, reports the analysis of photos and polarisation calculations and errors [fr

  20. Conception of a New Recoil Proton Telescope for Real-Time Neutron Spectrometry in Proton-Therapy

    Science.gov (United States)

    Combe, Rodolphe; Arbor, Nicolas; el Bitar, Ziad; Higueret, Stéphane; Husson, Daniel

    2018-01-01

    Neutrons are the main type of secondary particles emitted in proton-therapy. Because of the risk of secondary cancer and other late occurring effects, the neutron dose should be included in the out-of-field dose calculations. A neutron spectrometer has to be used to take into account the energy dependence of the neutron radiological weighting factor. Due to its high dependence on various parameters of the irradiation (beam, accelerator, patient), the neutron spectrum should be measured independently for each treatment. The current reference method for the measurement of the neutron energy, the Bonner Sphere System, consists of several homogeneous polyethylene spheres with increasing diameters equipped with a proportional counter. It provides a highresolution reconstruction of the neutron spectrum but requires a time-consuming work of signal deconvolution. New neutron spectrometers are being developed, but the main experimental limitation remains the high neutron flux in proton therapy treatment rooms. A new model of a real-time neutron spectrometer, based on a Recoil Proton Telescope technology, has been developed at the IPHC. It enables a real-time high-rate reconstruction of the neutron spectrum from the measurement of the recoil proton trajectory and energy. A new fast-readout microelectronic integrated sensor, called FastPixN, has been developed for this specific purpose. A first prototype, able to detect neutrons between 5 and 20 MeV, has already been validated for metrology with the AMANDE facility at Cadarache. The geometry of the new Recoil Proton Telescope has been optimized via extensive Geant4 Monte Carlo simulations. Uncertainty sources have been carefully studied in order to improve simultaneously efficiency and energy resolution, and solutions have been found to suppress the various expected backgrounds. We are currently upgrading the prototype for secondary neutron detection in proton therapy applications.

  1. On unfolding counting-rate spectra of recoil-proton neutron detectors

    International Nuclear Information System (INIS)

    Yeivin, Yehuda

    1983-01-01

    This note proposes a possible scheme for unfolding recoil-proton neutron detector data, in which at first the undistorted proton source spectrum is derived. The main argument in favour of this scheme is that, compared with the conventional scheme, it necessitates somewhat weaker assumptions with respect to the unknown spectrum above the detector's upper energy cutoff, and would therefore be more reliable. We also demonstrate a simple, elementary proof of the wall effect correction for spherical detectors, and, in order to gain insight of the potential merits of the proposed unfolding scheme, illustrate our main argument by considering a hypothetic linear range-energy relation, in which case complete unfolding becomes possible with no assumptions at all on the proton spectrum above the cutoff energy. (author)

  2. The design of a proton recoil telescope for 14 MeV neutron spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Hawkes, N.P.; Bond, D.S.; Croft, S.; Jarvis, O.N. E-mail: onj@jet.uk; Sherwood, A.C

    2002-01-01

    As part of the design effort for a 14 MeV neutron spectrometer for the Joint European Torus (JET), computer codes were developed to calculate the response of a proton recoil telescope comprising a proton radiator film mounted in front of a proton detector. The codes were used to optimise the geometrical configuration in terms of efficiency and resolution, bearing in mind the constraints imposed by the proposed application as a JET neutron diagnostic for the Deuterium-Tritium phase. A prototype instrument was built according to the optimised design, and tested with monoenergetic 14 MeV neutrons from the Harwell 500 keV Van de Graaff accelerator. The measured energy resolution and absolute efficiency were found to be in acceptable agreement with the calculations. Based on this work, a multi-radiator production version of the spectrometer has now been constructed and successfully deployed at JET.

  3. The design of a proton recoil telescope for 14 MeV neutron spectrometry

    International Nuclear Information System (INIS)

    Hawkes, N.P.; Bond, D.S.; Croft, S.; Jarvis, O.N.; Sherwood, A.C.

    2002-01-01

    As part of the design effort for a 14 MeV neutron spectrometer for the Joint European Torus (JET), computer codes were developed to calculate the response of a proton recoil telescope comprising a proton radiator film mounted in front of a proton detector. The codes were used to optimise the geometrical configuration in terms of efficiency and resolution, bearing in mind the constraints imposed by the proposed application as a JET neutron diagnostic for the Deuterium-Tritium phase. A prototype instrument was built according to the optimised design, and tested with monoenergetic 14 MeV neutrons from the Harwell 500 keV Van de Graaff accelerator. The measured energy resolution and absolute efficiency were found to be in acceptable agreement with the calculations. Based on this work, a multi-radiator production version of the spectrometer has now been constructed and successfully deployed at JET

  4. Commissioning and performance studies of a proton recoil detector at the COMPASS-II experiment

    Energy Technology Data Exchange (ETDEWEB)

    Joerg, Philipp; Buechele, Maximilian; Fischer, Horst; Gorzellik, Matthias; Grussenmeyer, Tobias; Herrmann, Florian; Koenigsmann, Kay; Kremser, Paul; Schopferer, Sebastian [Physikalisches Institut, Albert-Ludwigs-Universitaet Freiburg (Germany); Collaboration: COMPASS Collaboration

    2014-07-01

    The COMPASS-II experiment is a fixed target experiment situated at CERN. A tertiary myon beam from the SPS scattered of protons from a liquid hydrogen target is used to measure Deeply Virtual Compton Scattering (DVCS) and Hard Exclusive Meson Production (HEMP). These processes offer a unique way to determine Generalized Parton Distributions, which are related to the total angular momentum of quarks, antiquarks and gluons in the nucleon by Ji's Sum Rule. One of the major parts of the COMPASS-II upgrade is the CAMERA detector. CAMERA is a proton recoil detector surrounding the COMPASS-II liquid hydrogen target. Its purpose is to measure the recoiled target proton in DVCS and HEMP reactions and viz to act as a veto to ensure the exclusivity of the measurement. The talk gives an outline of the detector and its readout electronics. It is focused on the commissioning and performance of the CAMERA detector and gives a brief insight into the ongoing DVCS analysis.

  5. Proton recoil spectra in spherical proportional counters calculated with finite element and Monte Carlo methods

    Energy Technology Data Exchange (ETDEWEB)

    Benmosbah, M. [Laboratoire de Chimie Physique et Rayonnement Alain Chambaudet, UMR CEA E4, Universite de Franche-Comte, 16 route de Gray, 25030 Besancon Cedex (France); Groetz, J.E. [Laboratoire de Chimie Physique et Rayonnement Alain Chambaudet, UMR CEA E4, Universite de Franche-Comte, 16 route de Gray, 25030 Besancon Cedex (France)], E-mail: jegroetz@univ-fcomte.fr; Crovisier, P. [Service de Protection contre les Rayonnements, CEA Valduc, 21120 Is/Tille (France); Asselineau, B. [Laboratoire de Metrologie et de Dosimetrie des Neutrons, IRSN, Cadarache BP3, 13115 St Paul-lez-Durance (France); Truffert, H.; Cadiou, A. [AREVA NC, Etablissement de la Hague, DQSSE/PR/E/D, 50444 Beaumont-Hague Cedex (France)

    2008-08-11

    Proton recoil spectra were calculated for various spherical proportional counters using Monte Carlo simulation combined with the finite element method. Electric field lines and strength were calculated by defining an appropriate mesh and solving the Laplace equation with the associated boundary conditions, taking into account the geometry of every counter. Thus, different regions were defined in the counter with various coefficients for the energy deposition in the Monte Carlo transport code MCNPX. Results from the calculations are in good agreement with measurements for three different gas pressures at various neutron energies.

  6. A proton-recoil neutron spectrometer for time-dependent ion temperatures on the National Ignition Facility

    International Nuclear Information System (INIS)

    Murphy, T.J.

    1995-01-01

    Ion temperatures from inertial confinement fusion targets are usually determined by measuring the Doppler broadening of the neutron spectrum using the time-of-flight method. Measurement systems are generally designed so that the contribution of the duration of neutron production (∼100 ps) to the width of the neutron signal is negligible. This precludes the possibility of time-dependent ion temperature. If, however, one could measure the neutron energy and arrival time at a detector independently, then time-dependent neutron spectra could be obtained, and ion temperature information deduced. A concept utilizing a proton-recoil neutron spectrometer has been developed in which recoil protons from a small plastic foil are measured. From the energy, arrival time, and recoil angle of the recoil proton, the birth time and energy of the incident neutron can be deduced. The sensitivity of the system is low, but the higher anticipated neutron yields from the proposed National Ignition Facility may make the technique feasible. Large scintillator arrays currently in use on the Nova facility for neutron spectral measurements consist of ∼1,000 channels and detect between 50 and 500 counts for typical time-integrated data. Time-dependent results would then require about an order of magnitude larger system. Key issues for making this system feasible will be keeping the cost per channel low while allowing adequately time (∼ 50 ps), energy (20 keV), and angular resolution (2 mrad) for each of the proton detectors

  7. Hydrogen determination using secondary processes of recoil proton interaction with sample material

    International Nuclear Information System (INIS)

    Muminov, V.A.; Khajdarov, R.A.; Navalikhin, L.V.; Pardaev, Eh.

    1980-01-01

    Possibilities of hydrogen content determination in different materials according to secondary processes of interaction of recoil protons(irradiation in the field of fast neutrons) with sample material resulting in the appearance of characteristic X-ray irradiation are studied. Excitated irradiation is recorded with a detector placed in the protective screen and located at a certain distance from the object analyzed and neutron source. The method is tested taking as an example analysis of bromine-containing samples (30% Br, 0.5% H) and tungsten dioxide. The determination limit of hydrogen content constitutes 0.05% at confidence coefficient of 0.9. Neutron flux constituted 10 3 neutrons/cm 2 xs, the time of measurement being 15-20 minutes, the distance from the sample to the detector being 12-15 cm [ru

  8. Systematic investigation of background sources in neutron flux measurements with a proton-recoil silicon detector

    Energy Technology Data Exchange (ETDEWEB)

    Marini, P., E-mail: marini@cenbg.in2p3.fr [CENBG, CNRS/IN2P3-Université de Bordeaux, Chemin du Solarium B.P. 120, 33175 Gradignan (France); Mathieu, L. [CENBG, CNRS/IN2P3-Université de Bordeaux, Chemin du Solarium B.P. 120, 33175 Gradignan (France); Acosta, L. [Instituto de Física, Universidad Nacional Autónoma de México, Apartado Postal 20-364, México D.F. 01000 (Mexico); Aïche, M.; Czajkowski, S.; Jurado, B.; Tsekhanovich, I. [CENBG, CNRS/IN2P3-Université de Bordeaux, Chemin du Solarium B.P. 120, 33175 Gradignan (France)

    2017-01-01

    Proton-recoil detectors (PRDs), based on the well known standard H(n,p) elastic scattering cross section, are the preferred instruments to perform precise quasi-absolute neutron flux measurements above 1 MeV. The limitations of using a single silicon detector as PRD at a continuous neutron beam facility are investigated, with the aim of extending such measurements to neutron energies below 1 MeV. This requires a systematic investigation of the background sources affecting the neutron flux measurement. Experiments have been carried out at the AIFIRA facility to identify these sources. A study on the role of the silicon detector thickness on the background is presented and an energy limit on the use of a single silicon detector to achieve a neutron flux precision better than 1% is given.

  9. A new Recoil Proton Telescope for energy and fluence measurement of fast neutron fields

    Energy Technology Data Exchange (ETDEWEB)

    Lebreton, Lena; Bachaalany, Mario [IRSN / LMDN (Institut de Radioprotection et de Surete nucleaire / Laboratoire de Metrologie et de dosimetrie des neutrons), Cadarache Bat.159, 13115 Saint Paul-lez-Durance, (France); Husson, Daniel; Higueret, Stephane [IPHC / RaMsEs (Institut Pluridisciplinaire Hubert Curien / Radioprotection et Mesures Environnementales), 23 rue du loess - BP28, 67037 Strasbourg cedex 2, (France)

    2015-07-01

    The spectrometer ATHENA (Accurate Telescope for High Energy Neutron metrology Applications), is being developed at the IRSN / LMDN (Institut de Radioprotection et de Surete nucleaire / Laboratoire de Metrologie et de dosimetrie des neutrons) and aims at characterizing energy and fluence of fast neutron fields. The detector is a Recoil Proton Telescope and measures neutron fields in the range of 5 to 20 MeV. This telescope is intended to become a primary standard for both energy and fluence measurements. The neutron detection is achieved by a polyethylene radiator for n-p conversion, three 50{sub m} thick silicon sensors that use CMOS technology for the proton tracking and a 3 mm thick silicon diode to measure the residual proton energy. This first prototype used CMOS sensors called MIMOSTAR, initially developed for heavy ion physics. The use of CMOS sensors and silicon diode increases the intrinsic efficiency of the detector by a factor of ten compared with conventional designs. The first prototype has already been done and was a successful study giving the results it offered in terms of energy and fluence measurements. For mono energetic beams going from 5 to 19 MeV, the telescope offered an energy resolution between 5 and 11% and fluence difference going from 5 to 7% compared to other home standards. A second and final prototype of the detector is being designed. It will hold upgraded CMOS sensors called FastPixN. These CMOS sensors are supposed to run 400 times faster than the older version and therefore give the telescope the ability to support neutron flux in the order of 107 to 108cm{sup 2}:s{sup 1}. The first prototypes results showed that a 50 m pixel size is enough for a precise scattering angle reconstruction. Simulations using MCNPX and GEANT4 are already in place for further improvements. A DeltaE diode will replace the third CMOS sensor and will be installed right before the silicon diode for a better recoil proton selection. The final prototype with

  10. Properties enhancement and recoil loop characteristics for hot deformed nanocrystalline NdFeB permanent magnets

    International Nuclear Information System (INIS)

    Liu, Z. W.; Huang, Y. L.; Hu, S. L.; Zhong, X. C.; Yu, H. Y.; Gao, X. X.

    2013-01-01

    Nanocrystalline NdFeB magnets were prepared by spark plasma sintering (SPS) and SPS followed by HD using melt spun ribbons as the starting materials. The microstructure of SPSed and HDed magnets were analyzed. The effects of process including temperature and compression ratio on the microstructure and properties were investigated. High magnetic properties were obtained in anisotropic HDed magnets. The combination of Zn and Dy additions was successfully employed to improve the coercivity and thermal stability of the SPSed magnets. Open recoil loops were found in these magnets with Nd-rich composition and without soft magnetic phase for the first time. The relationship between the recoil loops and microstructure for SPS and HD NdFeB magnets were investigated. The investigations showed that the magnetic properties of SPS+HDed magnets are related to the extent of the aggregation of Nd-rich phase, which was formed during HD due to existence of porosity in SPSed precursor. Large local demagnetization fields induced by the Nd-rich phase aggregation leads to the open loops and significantly reduced the coercivity. By reducing the recoil loop openness, the magnetic properties of HDed NdFeB magnets were successfully improved. (author)

  11. Experiments with a magnetic separator for heavy recoil ions

    International Nuclear Information System (INIS)

    Mosler, E.

    1981-01-01

    Using a triple-focusing (position and momentum), crescent-shaped separator for heavy recoil-ions different experiments were performed. The improvement consists in the enhancement of the transmission from 8% to 25% for 500 keV recoil ions from the reaction 238 U(α, 3n)sup(239m)Pu. For sup(237m)Pu the electromagnetic decay of the 1.1 μs shape isomer into the 82 ns shape isomer was searched for. The upper limit for gamma decay is 1.25 +- 1.25% for Esub(γ) = 200 keV and for electron decay 0.29 +- 0.29% in comparison to isomeric fission. The upper limit for interband transitions is 2.5% (2 delta), from which the upper limit of the partial half-life for the electromagnetic decay of the 1.1 μs isomer is calculated to 44 μs. Due to the performed interpretation the spin difference between both isomers extends at least to ΔI = 3. For sup(238m)U the back-decay into the 1. minimum by the EO-transition and the converted 2 + → 0 + transition in the first decay and the decay by alpha articles was looked for both in single measurements as in a coincidence measurement to L-X-ray quanta. The upper limits are GAMMAsub(EO) = 2.0, GAMMAsub(α)/GAMMAsub(F) = 0.4 and GAMMA(back-decay)/GAMMAsub(F) approx. equal to 100. (orig./HSI) [de

  12. Neutron spectrometry for D-T plasmas in JET, using a tandem annular-radiator proton-recoil spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Hawkes, N.P.; Bond, D.S.; Kiptily, V.; Jarvis, O.N. E-mail: onj@jet.uk; Conroy, S.W

    2002-01-01

    A selection of the 14-MeV neutron spectra obtained at the JET Joint Undertaking tokamak during the deuterium-tritium operating campaign in 1997 are presented and analyzed. While several neutron spectrometers were operational during this campaign, the present paper is concerned solely with one: the tandem annular-radiator proton-recoil spectrometer (or proton recoil telescope, for brevity). During neutral beam heating with combined d- and t-beams, analysis of the spectra can define the core fuel composition (D:T) ratio. The spectra are sensitive to the population balance of the fast ions streaming in directions parallel and opposite to that of the injected beams. During ICRF heating of minority deuterium in bulk tritium plasmas, the spectra provide measurements of the effective temperature of the fast-deuteron energy tail and of its relative strength, which vary with the deuterium concentration. This information contributes to the overall understanding of the fusion performance of the various operating scenarios.

  13. Recoil proton polarization of neutral pion photoproduction from proton in the energy range between 400 MeV and 1142 MeV

    International Nuclear Information System (INIS)

    Kato, S.; Miyachi, T.; Sugano, K.; Toshioka, K.; Ukai, K.

    1979-08-01

    The recoil proton polarization of the reaction γp → π 0 p were measured at a C.M. angle of 100 0 for incident photon energies between 451 and 1106 MeV, and at an angle of 130 0 for energies from 400 MeV to 1142 MeV. One photon decayed from a π 0 -meson and a recoil proton were detected in coincidence. Two kinds of polarization scatterers were employed. In the range of proton kinetic energy less than 420 MeV and higher than 346 MeV, carbon plates and liquid hydrogen were used for determining the polarization. Results are compared with recent phenomenological analyses. From the Comparison between the present data and the asymmetry data given by the polarized target, the contribution of the invariant amplitudes A 3 can be estimated to be small at 100 0 . (author)

  14. Proton-recoil proportional-counter array for neutron-image construction

    International Nuclear Information System (INIS)

    Fink, C.L.; Eichholz, J.J.; DeVolpi, A.

    1984-01-01

    The fuel-motion measurement capability of the fast-neutron hodoscope has been upgraded by the addition of a 360-detector proton-recoil proportional-counter array, which detects high-energy fission neutrons. The current sensitive amplifier/discriminator module for each detector fits into a 12.7 by 12.7 by 102 mm package and cost less than $100 per module. It has a 50 ns rise time, a noise level of 100 nA, and a deadtime per event of 200 ns. Provision has been provided for the independent adjustment of the input current versus discriminator voltage for each module. The new proportional-counters cost approximately $400 each. Each detector has been tested to have the same gain versus voltage response. A space-charge model relating count-rate changes to space-charge effects has also been developed. The new detector array has been operational for approximately two years and has become the main detector system in fuel-motion analysis. It has significantly improved the linearity, stability, count-rate capability, and setup ease of the hodoscope

  15. Analysis of accelerator based neutron spectra for BNCT using proton recoil spectroscopy

    International Nuclear Information System (INIS)

    Wielopolski, L.; Ludewig, H.; Powell, J.R.; Raparia, D.; Alessi, J.G.; Lowenstein, D.I.

    1998-01-01

    using a proton recoil spectroscopy detection system. Comparison was also made between in phantom 10 BF 3 readings made at the BMRR and those made at the RARAF accelerator facility

  16. Measurement of recoil proton polarization in the process of. pi. /sup -/ photoproduction from neutrons in the energy range between 700 and 1200 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Takeda, H; Arai, I; Fujii, T; Ikeda, H; Iwasaki, H; Kajiura, N; Kamae, T; Kawabata, S; Ogawa, K; Sumiyoshi, T [Tokyo Univ. (Japan). Dept. of Physics

    1980-05-01

    The recoil proton polarization for ..gamma..n ..-->.. ..pi../sup -/p was measured around the third resonance region. Both momentum vectors of the proton and the pion were determined by the magnetic spectrometers. The proton polarization was measured by means of proton-carbon scattering in the polarization analyzer located behind the proton spectrometer. Below 900 MeV incident photon energy, our data are consistent with the other existing experimental data (THETA*sub..pi.. = 90/sup 0/) and the predictions of partial-wave analyses. Above 1000 MeV, however, a large discrepancy was observed between our data and the predictions of the partial-wave analyses. This discrepancy stands out as the pion c.m. angle increases. A new partial-wave analysis was made for ..gamma..n ..-->.. ..pi../sup -/p including our polarization data, and the accuracy of the experimentally determined electromagnetic coupling constants of the third resonances were greatly improved. In particular, a finite amount of the helicity 3/2 amplitude for the ..gamma..n ..-->.. F/sub 15/(1688) resonance was obtained against the predictions of the quark models, by Copley, Karl and Obryk and by Feynman, Kislinger and Ravendal but in agreement with the relativistic quark models of Sugimoto and Toya, and Kubota and Ohta.

  17. Velocity dependence of enhanced dynamic hyperfine field for Pd ions swiftly recoiling in magnetized Fe

    International Nuclear Information System (INIS)

    Stuchbery, A.E.; Ryan, G.C.; Bolotin, H.H.; Sie, S.H.

    1980-01-01

    The velocity-dependence of the magnitude of the enchanced dynamic hyperfine magnetic field (EDF) manifest at nuclei of 108 Pd ions swiftly recoiling through thin magnetized Fe has been investigated at ion velocities higher than have heretofore been examined for the heavier nuclides (i.e., at initial recoil velocities (v/Zv 0 )=0.090 and 0.160, v 0 =c/137). These results for 108 Pd, when taken in conjunction with those of prior similar measurements for 106 Pd at lower velocities, and fitted to a velocity dependence for the EDF, give for the Pd isotopes over the extended velocity range 1.74 0 )<=7.02, p=0.41+-0.15; a result incompatible with previous attributions of a linear velocity dependence for the field

  18. Velocity dependence of transient hyperfine field at Pt ions rapidly recoiling through magnetized Fe

    International Nuclear Information System (INIS)

    Stuchbery, A.E.; Ryan, C.G.; Bolotin, H.H.

    1981-01-01

    The velocity-dependence of the transient hyperfine magnetic field acting at nuclei of 196 Pt ions rapidly recoiling through thin magnetized Fe was investigated at a number of recoil velocities. The state of interest (2 1 + ) was populated by Coulomb excitation using beams of 80- and 120-MeV 32 S and 150- and 220-MeV 58 Ni ions. The 2 1 + →0 1 + γ-ray angular distribution precession measurements were carried out in coincidence with backscattered projectiles. From these results, the strength of the transient field acting on Pt ions recoiling through magnetized Fe with average velocities in the extended range 2.14<=v/vsub(o)<=4.82 (vsub(o) = c/137) was found to be consistent with a linear velocity dependence and to be incompatible with the specific vsup(0.45+-0.18) dependence which has been previously reported to account well for all ions in the mass range from oxygen through samarium. This seemingly singular behaviour for Pt and other ions in the Pt mass vicinity is discussed

  19. The G_E/G_M-ratio of the proton by recoil polarization measurement in e+parrow e'+p

    Science.gov (United States)

    Punjabi, Vina; Jones, Mark; Perdrisat, Charles F.; Quemener, Gilles

    1998-10-01

    The recently commissioned Hall A high resolution spectrometers (HRS) and the focal plane polarimeter (FPP) were used to obtain the ratio of the electric and magnetic form factors of the proton, G_E/G_M. This form factor ratio is proportional to the measured ratio of the transverse, P_t, to longitudinal, P_l, components of the recoiling proton polarization. The method takes advantage of the precession of the proton magnetic moment in the hadron HRS, which rotates the longitudinal polarization component into the plane of the FPP analyzer; this allows simultaneous measurement of both components of the polarization. The ratio P_t/P_l is independent of both the electron beam polarization and the polarimeter analyzing power. Most of the data were obtained with polarized beams of 100 μ A with polarization of ~ 0.39 incident on the 15 cm cell of the high power LH2 target. We will report the results for G_E/GM at several values of Q^2 between 0.5 and 3.5 GeV^2.

  20. Measurement of the proton form factors ratio GE/GM to Q2 = 5.6 GeV2 by recoil polarimetry

    Energy Technology Data Exchange (ETDEWEB)

    Gayou, Olivier [College of William and Mary, Williamsburg, VA (United States)

    2002-01-01

    In this thesis, we present the results of the experiment E99-007, which measured the ratio of the electric to magnetic form factors of the proton to the four momentum transfer square Q2 = 5.6 GeV2, by recoil polarimetry. Data were taken in 2000 at the Thomas Jefferson National Accelerator Facility in Virginia, USA. A 4.6 GeV polarized electron beam was scattered off a cryogenic hydrogen target. The polarization of the recoil proton was measured in the Focal Plane Polarimeter, located after one of the two High Resolution Spectrometers in the hall. The ratio of the transverse to longitudinal components of the recoil proton polarization is proportional to the ratio of the form factors. Elastic events were selected by detecting the scattered electron in a large acceptance lead-glass calorimeter. The main result of this experiment is the linear decrease of the form factor ratio with increasing Q2, corresponding to different spatial distributions of the electric charge and the magnetization. Numerous theoretical calculations show that relativistic effects, such as mixing of spin states due to Lorentz boosts, are important to account for the observed data in this critical intermediate kinematic region.

  1. Detection of low momentum protons with the new HERMES recoil detector

    Energy Technology Data Exchange (ETDEWEB)

    Vilardi, Ignazio

    2008-10-15

    In this theis the recoil detector for the HERMES experiment at HERA is described. It consists of a silicon strip detector, a scintillating fiber tracker, and a photon detector for the {delta}{sup +} background rejection, all surrounded by a superconducting 1 Tesla solenoid. Results of cosmic ray tests are presented. (HSI)

  2. Detection of low momentum protons with the new HERMES recoil detector

    International Nuclear Information System (INIS)

    Vilardi, Ignazio

    2008-10-01

    In this theis the recoil detector for the HERMES experiment at HERA is described. It consists of a silicon strip detector, a scintillating fiber tracker, and a photon detector for the Δ + background rejection, all surrounded by a superconducting 1 Tesla solenoid. Results of cosmic ray tests are presented. (HSI)

  3. Spectral flux of the p-7Li(C Q-M neutron source measured by proton recoil telescope

    Directory of Open Access Journals (Sweden)

    Simakov S.P.

    2010-10-01

    Full Text Available The cyclotron-based fast neutron source at NPI produces mono-energetic neutron fields up to 35 MeV neutron energy using the p + 7Li(carbon backing reactions. To be applied for activation cross-section measurements, not only the intensity of neutron peak, but also the contribution of low-energy continuum in the spectra must be well determined. Simulations of the spectral flux from present source at a position of irradiated samples were performed using CYRIC TOF-data validated in the present work against LA150h by calculations with the transport Monte Carlo code MCNPX. Simulated spectra were tested by absolute measurements using a proton-recoil telescope technique. The recoil-proton spectrometer consisted of a shielded scattering chamber with polyethylene and carbon radiators and the ΔE1-ΔE2-E telescope of silicon-surface detectors located to the neutron beam axis at 45° in the laboratory system. Si-detectors were handled by usual data acquisition system. Dead-time – and pulse-overlap losses of events were determined from the count rate of pulse generator registered during duty cycle of accelerator operation. The proton beam charge and data were taken in the list mode for later replay and analysis. The calculations for 7Li(p,n and 12C(p,n reactions reasonably reproduce CYRIC TOF neutron source spectra. The influence of neutron source set-up (proton beam dimensions, 7Li-foil, carbon stopper, cooling medium, target support/chamber and the geometry-arrangement of irradiated sample on the spectral flux is discussed in details.

  4. Neutron spectrometry with proton recoil proportional counters at the research and measurement reactor Braunschweig - status of the technique

    International Nuclear Information System (INIS)

    Knauf, K.; Wittstock, J.

    1987-07-01

    This status report is concerned with the facilities set up for neutron spectrometry at the Research and Measurement Reactor Braunschweig, based on proton recoil proportional counters. Cylindrical counters for irradiation by a neutron beam normal to the counter wire and commercial spherical counters are employed. They can be filled with hydrogen or a hydrogeneous gas up to a pressure of 1 MPa depending on their use. The filling method and the electronic pulse processing are described. The pulse analysis system includes a pulse shape discrimination branch in order to separate γ-ray induced pulses. Finally, experimental investigations with spherical counters are discussed regarding the region of proportionality and the influence of the counter voltage on the shape of the response function. (orig./HP) [de

  5. Recoil curve properties and coercive force decrease ratio in NdFeB sintered magnets

    Energy Technology Data Exchange (ETDEWEB)

    Matsuura, Yutaka, E-mail: Yutaka_Matsuura@hitachi-metals.co.jp; Kitai, Nobuyuki; Ishii, Rintaro; Natsumeda, Toshimitsu; Hoshijima, Jun

    2013-11-15

    It is examined that whether a reverse domain and magnetic domain wall exist in a lower demagnetization area than the coercive force and whether the observed demagnetization ratio curve can be explained using the alignment distribution function or not. From measurements of the recoil curve in the low demagnetization field, it was confirmed that minor demagnetization occurred in every demagnetization field and magnets of every grade of coercive force. The alignment distribution of Nd{sub 2}Fe{sub 14}B grains was also measured by electron back-scattering diffraction (EBSD). The alignments and the coercive force decrease ratios were calculated using these alignment distributions. These data were compared against the results obtained from magnetization measurements. From EBSD data, it was found that the alignment distributions of magnets used in this experiment were close to a Gaussian distribution. It was also found that there was no difference in the alignment distribution between magnets with Dy and without Dy, even though the coercive force decrease ratios were Dy dependent. The calculated alignments using the alignment distribution functions were close to the values of magnetization measurements. However, it was found that the calculated coercive force decrease ratios were different from the results obtained from magnetization measurement. - Highlights: • Reverse magnetic domains already exist lower magnetic field than coercive force. • Demagnetization happens not only from surface but also from inside of magnets. • Calculated alignment agrees well with that of the magnetic properties measurement. • Coercive force decrease ratio could not explain from alignment distribution. • We could not find any difference with and without Dy magnets in alignment distribution.

  6. The Magnetic Recoil Spectrometer for time-resolved neutron measurements (MRSt) at the NIF

    Science.gov (United States)

    Parker, C. E.; Frenje, J. A.; Wink, C. W.; Gatu Johnson, M.; Lahmann, B.; Li, C. K.; Seguin, F. H.; Petrasso, R. D.; Hilsabeck, T. J.; Kilkenny, J. D.; Bionta, R.; Casey, D. T.; Khater, H. Y.; Forrest, C. J.; Glebov, V. Yu.; Sorce, C.; Hares, J. D.; Siegmund, O. H. W.

    2017-10-01

    The next-generation Magnetic Recoil Spectrometer, called MRSt, will provide time-resolved measurements of the DT-neutron spectrum. These measurements will provide critical information about the time evolution of the fuel assembly, hot-spot formation, and nuclear burn in Inertial Confinement Fusion (ICF) implosions at the National Ignition Facility (NIF). The neutron spectrum in the energy range 12-16 MeV will be measured with high accuracy ( 5%), unprecedented energy resolution ( 100 keV) and, for the first time ever, time resolution ( 20 ps). An overview of the physics motivation, conceptual design for meeting these performance requirements, and the status of the offline tests for critical components will be presented. This work was supported in part by the U.S. DOE, LLNL, and LLE.

  7. The magnetic recoil spectrometer for measurements of the absolute neutron spectrum at OMEGA and the NIF

    International Nuclear Information System (INIS)

    Casey, D. T.; Frenje, J. A.; Gatu Johnson, M.; Séguin, F. H.; Li, C. K.; Petrasso, R. D.; Glebov, V. Yu.; Katz, J.; Magoon, J.; Meyerhofer, D. D.; Sangster, T. C.; Shoup, M.; Ulreich, J.; Ashabranner, R. C.; Bionta, R. M.; Carpenter, A. C.; Felker, B.; Khater, H. Y.; LePape, S.; MacKinnon, A.

    2013-01-01

    The neutron spectrum produced by deuterium-tritium (DT) inertial confinement fusion implosions contains a wealth of information about implosion performance including the DT yield, ion-temperature, and areal-density. The Magnetic Recoil Spectrometer (MRS) has been used at both the OMEGA laser facility and the National Ignition Facility (NIF) to measure the absolute neutron spectrum from 3 to 30 MeV at OMEGA and 3 to 36 MeV at the NIF. These measurements have been used to diagnose the performance of cryogenic target implosions to unprecedented accuracy. Interpretation of MRS data requires a detailed understanding of the MRS response and background. This paper describes ab initio characterization of the system involving Monte Carlo simulations of the MRS response in addition to the commission experiments for in situ calibration of the systems on OMEGA and the NIF.

  8. Measuring the absolute DT neutron yield using the Magnetic Recoil Spectrometer at OMEGA and the NIF

    Energy Technology Data Exchange (ETDEWEB)

    Mackinnon, A; Casey, D; Frenje, J A; Johnson, M G; Seguin, F H; Li, C K; Petrasso, R D; Glebov, V Y; Katz, J; Knauer, J; Meyerhofer, D; Sangster, T; Bionta, R; Bleuel, D; Hachett, S P; Hartouni, E; Lepape, S; Mckernan, M; Moran, M; Yeamans, C

    2012-05-03

    A Magnetic Recoil Spectrometer (MRS) has been installed and extensively used on OMEGA and the National Ignition Facility (NIF) for measurements of the absolute neutron spectrum from inertial confinement fusion (ICF) implosions. From the neutron spectrum measured with the MRS, many critical implosion parameters are determined including the primary DT neutron yield, the ion temperature, and the down-scattered neutron yield. As the MRS detection efficiency is determined from first principles, the absolute DT neutron yield is obtained without cross-calibration to other techniques. The MRS primary DT neutron measurements at OMEGA and the NIF are shown to be in excellent agreement with previously established yield diagnostics on OMEGA, and with the newly commissioned nuclear activation diagnostics on the NIF.

  9. The magnetic recoil spectrometer for measurements of the absolute neutron spectrum at OMEGA and the NIF.

    Science.gov (United States)

    Casey, D T; Frenje, J A; Johnson, M Gatu; Séguin, F H; Li, C K; Petrasso, R D; Glebov, V Yu; Katz, J; Magoon, J; Meyerhofer, D D; Sangster, T C; Shoup, M; Ulreich, J; Ashabranner, R C; Bionta, R M; Carpenter, A C; Felker, B; Khater, H Y; LePape, S; MacKinnon, A; McKernan, M A; Moran, M; Rygg, J R; Yeoman, M F; Zacharias, R; Leeper, R J; Fletcher, K; Farrell, M; Jasion, D; Kilkenny, J; Paguio, R

    2013-04-01

    The neutron spectrum produced by deuterium-tritium (DT) inertial confinement fusion implosions contains a wealth of information about implosion performance including the DT yield, ion-temperature, and areal-density. The Magnetic Recoil Spectrometer (MRS) has been used at both the OMEGA laser facility and the National Ignition Facility (NIF) to measure the absolute neutron spectrum from 3 to 30 MeV at OMEGA and 3 to 36 MeV at the NIF. These measurements have been used to diagnose the performance of cryogenic target implosions to unprecedented accuracy. Interpretation of MRS data requires a detailed understanding of the MRS response and background. This paper describes ab initio characterization of the system involving Monte Carlo simulations of the MRS response in addition to the commission experiments for in situ calibration of the systems on OMEGA and the NIF.

  10. Fast neutron spectroscopy by gas proton-recoil methods at the light water reactor pressure vessel simulator

    International Nuclear Information System (INIS)

    Rogers, J.W.

    1980-10-01

    Fast neutron spectrum measurements were made in a Light Water Reactor (LWR) Pressure Vessel Simulator (PVS) to provide neutron spectral definition required to appropriately perform and interpret neutron dosimetry measurements related to fast neutron damage in LWR-PV steels. Proton-recoil proportional counter methods using hydrogen and methane gas-filled detectors were applied to obtain the proton spectra from which the neutron spectra were derived. Cylindrical and spherical geometry detectors were used to cover the neutron energy range between 50 keV and 2 MeV. Results show that the neutron spectra shift in energy distribution toward lower energy between the front and back of a PVS. The relative neutron flux densities increase in this energy range with increasing thickness of the steel. Neutron spectrum fine structure shapes and changes are observed. These results should assist in the generation of more accurate effective cross sections and fluences for use in LWR-PV fast neutron dosimetry and materials damage analyses

  11. Automatic detection of recoil-proton tracks and background rejection criteria in liquid scintillator-micro-capillary-array fast neutron spectrometer

    Science.gov (United States)

    Mor, Ilan; Vartsky, David; Dangendorf, Volker; Tittelmeier, Kai.; Weierganz, Mathias; Goldberg, Mark Benjamin; Bar, Doron; Brandis, Michal

    2018-06-01

    We describe an analysis procedure for automatic unambiguous detection of fast-neutron-induced recoil proton tracks in a micro-capillary array filled with organic liquid scintillator. The detector is viewed by an intensified CCD camera. This imaging neutron detector possesses the capability to perform high position-resolution (few tens of μm), energy-dispersive transmission-imaging using ns-pulsed beams. However, when operated with CW or DC beams, it also features medium-quality spectroscopic capabilities for incident neutrons in the energy range 2-20 MeV. In addition to the recoil proton events which display a continuous extended track structure, the raw images exhibit complex ion-tracks from nuclear interactions of fast-neutrons in the scintillator, capillaries quartz-matrix and CCD. Moreover, as expected, one also observes a multitude of isolated scintillation spots of varying intensity (henceforth denoted "blobs") that originate from several different sources, such as: fragmented proton tracks, gamma-rays, heavy-ion reactions as well as events and noise that occur in the image-intensifier and CCD. In order to identify the continuous-track recoil proton events and distinguish them from all these background events, a rapid, computerized and automatic track-recognition-procedure was developed. Based on an appropriately weighted analysis of track parameters such as: length, width, area and overall light intensity, the method is capable of distinguishing a single continuous-track recoil proton from typically surrounding several thousands of background events that are found in each CCD frame.

  12. First measurement of the VESUVIO neutron spectrum in the 30–80 MeV energy range using a Proton Recoil Telescope technique

    International Nuclear Information System (INIS)

    Cazzaniga, C; Tardocchi, M; Croci, G; Grosso, G; Rebai, M; Gorini, G; Frost, C; Rhodes, N J; Schooneveld, E M; Giacomelli, L; Hjalmarsson, A

    2013-01-01

    Measurements of the fast neutron energy spectrum at the ISIS spallation source are reported. The measurements were performed with a Proton Recoil Telescope consisting of a thin plastic foil placed in the neutron beam and two scintillator detectors. Results in the neutron energy range 30 MeV n < 80 MeV are in good agreement with Monte Carlo simulations of the neutron spectrum

  13. First measurement of the VESUVIO neutron spectrum in the 30-80 MeV energy range using a Proton Recoil Telescope technique

    Science.gov (United States)

    Cazzaniga, C.; Tardocchi, M.; Croci, G.; Frost, C.; Giacomelli, L.; Grosso, G.; Hjalmarsson, A.; Rebai, M.; Rhodes, N. J.; Schooneveld, E. M.; Gorini, G.

    2013-11-01

    Measurements of the fast neutron energy spectrum at the ISIS spallation source are reported. The measurements were performed with a Proton Recoil Telescope consisting of a thin plastic foil placed in the neutron beam and two scintillator detectors. Results in the neutron energy range 30 MeV < En < 80 MeV are in good agreement with Monte Carlo simulations of the neutron spectrum.

  14. Recoil properties of radionuclides formed in the interaction of 1--300-GeV protons with gold

    International Nuclear Information System (INIS)

    Kaufman, S.B.; Steinberg, E.P.; Weisfield, M.W.

    1978-01-01

    The thick-target recoil properties of a number of nuclides, varying from 22 Na to 196 AU, formed in the interaction of 1--300-GeV protons with 197 Au have been measured in order to study the systematics of their variation with product mass and incident energy. The forward-to-backward ratios (F/B) of many of the products have a peak at 3 GeV and decrease at higher energies, with products in the mass region 46 or approx. = 140 decrease montonically between 1 and 300 GeV. The results are analyzed by the two-step model of high-energy reactions and discussed in terms of the different reaction mechanisms, spallation, fission and fragmentation. Fission contributes appreciably to the formation of products in the mass region 46 < or = A < or =103 at 1 GeV bombarding energy, but other mechanisms predominate at and above 11.5 GeV. The results are compared to the predictions of intranuclear cascade-evaporation calculations, and are in reasonable agreement at 1 and 3 GeV, although the calculations predict more forward momentum transfer than is observed. At higher energies the relation between forward momentum and mean deposition energy derived from the calculations must break down, because nuclides requiring high deposition energies for their formation have little or no forward momentum. Some possible explanations for this phenomenon are discussed

  15. Internal magnetic target of proton synchrotron

    International Nuclear Information System (INIS)

    Gachurin, V.V.; Kats, M.M.; Kondrat'ev, L.N.; Rogal', A.D.; Rusinov, V.Yu.

    1988-01-01

    Proton extraction from a synchrotron by means of an internal target of magnetized iron is described. The particles that are aimed at the target pass directly through it and are deflected by the internal magnetic field of the target in the extraction direction. The general properties of magnetic targets are examined theoretically and a specific devices and results of its testing are described

  16. Measurement of the proton recoil spectrum in neutron beta decay with the spectrometer aSPECT. Study of systematic effects

    Energy Technology Data Exchange (ETDEWEB)

    Konrad, Gertrud Emilie

    2012-01-24

    Free neutron decay, n{yields}pe anti {nu}{sub e}, is the simplest nuclear beta decay, well described as a purely left-handed, vector minus axial-vector interaction within the framework of the Standard Model (SM) of elementary particles and fields. Due to its highly precise theoretical description, neutron beta decay data can be used to test certain extensions to the SM. Possible extensions require, e.g., new symmetry concepts like left-right symmetry, new particles, leptoquarks, supersymmetry, or the like. Precision measurements of observables in neutron beta decay address important open questions of particle physics and cosmology, and are generally complementary to direct searches for new physics beyond the SM in high-energy physics. In this doctoral thesis, a measurement of the proton recoil spectrum with the neutron decay spectrometer aSPECT is described. From the proton spectrum the antineutrinoelectron angular correlation coefficient a can be derived. In our first beam time at the Forschungs-Neutronenquelle Heinz Maier-Leibnitz in Munich, Germany (2005-2006), background instabilities due to particle trapping and the electronic noise level of the proton detector prevented us from presenting a new value for a. In the latest beam time at the Institut Laue-Langevin (ILL) in Grenoble, France (2007-2008), the trapped particle background has been reduced sufficiently and the electronic noise problem has essentially been solved. For the first time, a silicon drift detector was used. As a result of the data analysis, we identified and fixed a problem in the detector electronics which caused a significant systematic error. The target figure of the latest beam time was a new value for a with a total relative error well below the present literature value of 4 %. A statistical accuracy of about 1.4% was reached, but we could only set upper limits on the correction of the problem in the detector electronics, which are too high to determine a meaningful result. The present

  17. Measurement of the proton recoil spectrum in neutron beta decay with the spectrometer aSPECT. Study of systematic effects

    International Nuclear Information System (INIS)

    Konrad, Gertrud Emilie

    2012-01-01

    Free neutron decay, n→pe anti ν e , is the simplest nuclear beta decay, well described as a purely left-handed, vector minus axial-vector interaction within the framework of the Standard Model (SM) of elementary particles and fields. Due to its highly precise theoretical description, neutron beta decay data can be used to test certain extensions to the SM. Possible extensions require, e.g., new symmetry concepts like left-right symmetry, new particles, leptoquarks, supersymmetry, or the like. Precision measurements of observables in neutron beta decay address important open questions of particle physics and cosmology, and are generally complementary to direct searches for new physics beyond the SM in high-energy physics. In this doctoral thesis, a measurement of the proton recoil spectrum with the neutron decay spectrometer aSPECT is described. From the proton spectrum the antineutrinoelectron angular correlation coefficient a can be derived. In our first beam time at the Forschungs-Neutronenquelle Heinz Maier-Leibnitz in Munich, Germany (2005-2006), background instabilities due to particle trapping and the electronic noise level of the proton detector prevented us from presenting a new value for a. In the latest beam time at the Institut Laue-Langevin (ILL) in Grenoble, France (2007-2008), the trapped particle background has been reduced sufficiently and the electronic noise problem has essentially been solved. For the first time, a silicon drift detector was used. As a result of the data analysis, we identified and fixed a problem in the detector electronics which caused a significant systematic error. The target figure of the latest beam time was a new value for a with a total relative error well below the present literature value of 4 %. A statistical accuracy of about 1.4% was reached, but we could only set upper limits on the correction of the problem in the detector electronics, which are too high to determine a meaningful result. The present doctoral

  18. Chemical effects of 13N produced by recoil protons and deuterons in pile-irradiated methanol and methanol-d4

    International Nuclear Information System (INIS)

    Sensui, Y.; Tomura, K.; Matsuura, T.

    1982-01-01

    The stabilized chemical forms of 13 N resulting from the reactions 13 C(p,n) 13 N by a recoil proton and 12 C(d,n) 13 N by a recoil deuteron, were studied in pile-irradiated methanol and methanol-d 4 in the temperature range from 77 to 295 K. Contrary to the target of benzene, cyclohexane, acetone and diethyl ether previously studied, the relative yield of 13 N-compounds did not depend on the irradiation temperature in the present media. In the yield of 13 N-compounds no marked change was observed between methanol and methanol-d 4 , differing from the results between benzene and benzene-d 6 . A mechanism is proposed to explain the results. (author)

  19. Focussing magnets for proton Linac of ADS

    International Nuclear Information System (INIS)

    Malhotra, Sanjay; Mahapatra, U.; Singh, Pitamber; Choudhury, R.K.; Goel, Priyanshu; Verma, Vishnu; Bhattacharya, S.; Srivastava, G.P.; Kailas, S.; Sahni, V.C.

    2009-01-01

    A linear accelerator comprising of Radio frequency quadruple (RFQ) and drift tube linac (DTL) is being developed by BARC. The Alvarez type post-coupled cw DTL accelerates protons from an energy of 3 MeV to 20 MeV. The drift tube linac is excited in TM010 mode, wherein the particles are accelerated by longitudinal electric fields at the gap crossings between drift tubes. The particles are subjected to transverse RF defocusing forces at the gap crossings due to the increasing electric fields in the gap. The transverse defocusing is corrected by housing magnetic quadrupole focussing lenses inside the drift tubes. The permanent magnet quadrupoles (PMQs) are placed inside the hermetically sealed drift tubes and provide a constant magnetic field gradient in the beam aperture. This paper discusses various aspects of magnetic design, selection of magnetic materials and the engineering development involved in the prototype development of these drift tubes for proton Linac. (author)

  20. Proton capture by magnetic monopoles

    International Nuclear Information System (INIS)

    Olaussen, K.; Olsen, H.A.; Oeverboe, I.; Osland, P.

    1983-09-01

    In the Kazama-Yang approximation, the lowest monopole-proton bound states have binding energies of 938 MeV, 263 keV, 105 eV, and 0.04 eV. The cross section for radiative capture to these states is for velocities β = 10 -5 - 10 -3 found to be of the order of 10 -28 - 10 -26 cm 2 . For the state that has a binding energy of 263 keV, the capture length in water is 171 x (β/10 -4 )sup(0.48) m. Observation of photons from the capture process would indicate the presence of monopoles. (orig.)

  1. Light response of YAP:Ce and LaBr{sub 3}:Ce scintillators to 4–30 MeV protons for applications to Telescope Proton Recoil neutron spectrometers

    Energy Technology Data Exchange (ETDEWEB)

    Cazzaniga, C., E-mail: carlo.cazzaniga@stfc.ac.uk [ISIS Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Didcot OX11 0QX (United Kingdom); Istituto di Fisica del Plasma “P. Caldirola”, Associazione EURATOM-ENEA/CNR, Via Cozzi 53, Milano (Italy); Cremona, A. [Istituto di Fisica del Plasma “P. Caldirola”, Associazione EURATOM-ENEA/CNR, Via Cozzi 53, Milano (Italy); Nocente, M.; Rebai, M.; Rigamonti, D. [Istituto di Fisica del Plasma “P. Caldirola”, Associazione EURATOM-ENEA/CNR, Via Cozzi 53, Milano (Italy); Università degli Studi di Milano-Bicocca, Dipartimento di Fisica, Piazza della Scienza 3, Milano (Italy); Tardocchi, M. [Istituto di Fisica del Plasma “P. Caldirola”, Associazione EURATOM-ENEA/CNR, Via Cozzi 53, Milano (Italy); Croci, G. [Istituto di Fisica del Plasma “P. Caldirola”, Associazione EURATOM-ENEA/CNR, Via Cozzi 53, Milano (Italy); Università degli Studi di Milano-Bicocca, Dipartimento di Fisica, Piazza della Scienza 3, Milano (Italy); Ericsson, G. [Department of Physics and Astronomy, EURATOM-VR Association, Uppsala University, Uppsala (Sweden); Fazzi, A. [Department of Energy of the Politecnico di Milano, via Lambruschini 4, I-20156 Milano (Italy); Hjalmarsson, A. [Department of Physics and Astronomy, EURATOM-VR Association, Uppsala University, Uppsala (Sweden); Mazzocco, M.; Strano, E. [Dipartimento di Fisica e Astronomia, Universitá di Padova, and INFN, Sez. di Padova, I-35131 Padova (Italy); and others

    2016-06-01

    The light response of two thin inorganic scintillators based on YAP:Ce and LaBr{sub 3}:Ce crystals has been measured with protons in the 4–8 MeV energy range at the Uppsala tandem accelerator and in the 8–26 MeV energy range at the Legnaro tandem accelerator. The crystals have been calibrated in situ with {sup 137}Cs and {sup 60}Co γ-ray sources. The relative light yields of protons with respect to gammas have been measured and are here reported to be (96±2)% and (80±2)% for YAP:Ce and LaBr{sub 3}:Ce, respectively. The results open up to the development of a Telescope Proton Recoil spectrometer based on either of the two crystals as alternative to a silicon based spectrometer for applications to high neutron fluxes.

  2. Magnetic monopole catalysis of proton decay

    International Nuclear Information System (INIS)

    Marciano, W.J.; Salvino, D.

    1986-09-01

    Catalysis of proton decay by GUT magnetic monopoles (the Rubakov-Callan effect) is discussed. Combining a short-distance cross section calculation by Bernreuther and Craigie with the long-distance velocity dependent distortion factors of Arafune and Fukugita, catalysis rate predictions which can be compared with experiment are obtained. At present, hydrogen rich detectors such as water (H 2 O) and methane (CH 4 ) appear to be particularly well suited for observing catalysis by very slow monopoles. 17 refs., 1 fig

  3. Recoil ions

    International Nuclear Information System (INIS)

    Cocke, C.L.; Olson, R.E.

    1991-01-01

    The collision of a fast moving heavy ion with a neutral atomic target can produce very highly charged but slowly moving target ions. This article reviews experimental and theoretical work on the production and use of recoil ions beyond the second ionization state by beams with specific energies above 0.5 MeV/amu. A brief historical survey is followed by a discussion of theoretical approaches to the problem of the removal of many electrons from a neutral target by a rapid, multiply charged projectile. A discussion of experimental techniques and results for total and differential cross sections for multiple ionization of atomic and molecular targets is given. Measurements of recoil energy are discussed. The uses of recoil ions for in situ spectroscopy of multiply charged ions, for external beams of slow, highly charged ions and in ion traps are reviewed. Some possible future opportunities are discussed. (orig.)

  4. Detecting neutrons by forward recoil protons at the Energy & Transmutation facility: Detector development and calibration with 14.1-MeV neutrons

    Science.gov (United States)

    Afanasev, S.; Vishnevskiy, A.; Vishnevskiy, D.; Rogachev, A.; Tyutyunnikov, S.

    2017-05-01

    As part of the Energy & Transmutation project, we are developing a detector for neutrons with energies in the 10-100 MeV range emitted from the target irradiated by a charged-particle beam. The neutron is detected by measuring the time-of-flight and total kinetic energy of the forward-going recoil proton [1] knocked out at a small angle from a thin layer of plastic scintillator, which has to be selected against an intense background created by γ quanta, scattered neutrons, and charged particles. On the other hand, neutron energy has to be measured over the full range with no extra tuning of the detector operation regime. Initial measurements with a source of 14.1-MeV neutrons are reported.

  5. The HERMES recoil detector

    International Nuclear Information System (INIS)

    Airapetian, A.; Belostotski, S.

    2013-02-01

    For the final running period of HERA, a recoil detector was installed at the HERMES experiment to improve measurements of hard exclusive processes in charged-lepton nucleon scattering. Here, deeply virtual Compton scattering is of particular interest as this process provides constraints on generalised parton distributions that give access to the total angular momenta of quarks within the nucleon. The HERMES recoil detector was designed to improve the selection of exclusive events by a direct measurement of the four-momentum of the recoiling particle. It consisted of three components: two layers of double-sided silicon strip sensors inside the HERA beam vacuum, a two-barrel scintillating fibre tracker, and a photon detector. All sub-detectors were located inside a solenoidal magnetic field with an integrated field strength of 1Tm. The recoil detector was installed in late 2005. After the commissioning of all components was finished in September 2006, it operated stably until the end of data taking at HERA end of June 2007. The present paper gives a brief overview of the physics processes of interest and the general detector design. The recoil detector components, their calibration, the momentum reconstruction of charged particles, and the event selection are described in detail. The paper closes with a summary of the performance of the detection system.

  6. The HERMES recoil detector

    Energy Technology Data Exchange (ETDEWEB)

    Airapetian, A. [Giessen Univ. (Germany). Physikalisches Inst.; Michigan Univ., Ann Arbor, MI (United States). Randall Laboratory of Physics; Aschenauer, E.C. [DESY, Zeuthen (Germany); Belostotski, S. [B.P. Konstantinov Petersburg Nuclear Physics Insitute, Gatchina (Russian Federation)] [and others; Collaboration: HERMES Recoil Detector Group

    2013-02-15

    For the final running period of HERA, a recoil detector was installed at the HERMES experiment to improve measurements of hard exclusive processes in charged-lepton nucleon scattering. Here, deeply virtual Compton scattering is of particular interest as this process provides constraints on generalised parton distributions that give access to the total angular momenta of quarks within the nucleon. The HERMES recoil detector was designed to improve the selection of exclusive events by a direct measurement of the four-momentum of the recoiling particle. It consisted of three components: two layers of double-sided silicon strip sensors inside the HERA beam vacuum, a two-barrel scintillating fibre tracker, and a photon detector. All sub-detectors were located inside a solenoidal magnetic field with an integrated field strength of 1Tm. The recoil detector was installed in late 2005. After the commissioning of all components was finished in September 2006, it operated stably until the end of data taking at HERA end of June 2007. The present paper gives a brief overview of the physics processes of interest and the general detector design. The recoil detector components, their calibration, the momentum reconstruction of charged particles, and the event selection are described in detail. The paper closes with a summary of the performance of the detection system.

  7. Simulation Study of Using High-Z EMA to Suppress Recoil Protons Crosstalk in Scintillating Fiber Array for 14.1 MeV Neutron Imaging

    Science.gov (United States)

    Jia, Qinggang; Hu, Huasi; Zhang, Fengna; Zhang, Tiankui; Lv, Wei; Zhan, Yuanpin; Liu, Zhihua

    2013-12-01

    This paper studies the effect of a high-Z extra mural absorber (EMA) to improve the spatial resolution of a plastic (polystyrene) scintillating fiber array for 14.1 MeV fusion neutron imaging. Crosstalk induced by recoil protons was studied, and platinum (Pt) was selected as EMA material, because of its excellent ability to suppress the recoil protons penetrating the fibers. Three common fiber arrays (cylindrical scintillating fibers in square and hexagonal packing arrangements and square scintillating fibers) were simulated using the Monte Carlo method for evaluating the effect of Pt-EMA in improving spatial resolution. It is found that the resolution of the 100 μm square fiber array can be improved from 1.7 to 3.4 lp/mm by using 10- μm-thick Pt-EMA; comparatively, using an array with thinner square fibers (50 μm) only obtains a resolution of 2.1 lp/mm. The packing fraction decreases with the increase of EMA thickness. Our results recommend the use of 10 μm Pt-EMA for the square and the cylindrical (hexagonal packing) scintillating fiber arrays with fibers of 50-200 μm in the cross-sectional dimension. Besides, the dead-zone material should be replaced by high-Z material for the hexagonal packing cylindrical fiber array with fibers of 50-200 μm in diameter. Tungsten (W) and gold (Au) are also used as EMA in the three fiber arrays as a comparison. The simulation results show that W can be used at a lower cost, and Au does not have any advantages in cost and resolution improvement.

  8. The magnetic recoil spectrometer (MRSt) for time-resolved measurements of the neutron spectrum at the National Ignition Facility (NIF)

    Energy Technology Data Exchange (ETDEWEB)

    Frenje, J. A., E-mail: jfrenje@psfc.mit.edu; Wink, C. W.; Gatu Johnson, M.; Li, C. K.; Séguin, F. H.; Petrasso, R. D. [Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Hilsabeck, T. J.; Kilkenny, J. D. [General Atomics, San Diego, California 92186 (United States); Bell, P.; Bionta, R.; Cerjan, C. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States)

    2016-11-15

    The next-generation magnetic recoil spectrometer for time-resolved measurements of the neutron spectrum has been conceptually designed for the National Ignition Facility. This spectrometer, called MRSt, represents a paradigm shift in our thinking about neutron spectrometry for inertial confinement fusion applications, as it will provide simultaneously information about the burn history and time evolution of areal density (ρR), apparent ion temperature (T{sub i}), yield (Y{sub n}), and macroscopic flows during burn. From this type of data, an assessment of the evolution of the fuel assembly, hotspot, and alpha heating can be made. According to simulations, the MRSt will provide accurate data with a time resolution of ∼20 ps and energy resolution of ∼100 keV for total neutron yields above ∼10{sup 16}. At lower yields, the diagnostic will be operated at a higher-efficiency, lower-energy-resolution mode to provide a time resolution of ∼20 ps.

  9. The magnetic recoil spectrometer (MRSt) for time-resolved measurements of the neutron spectrum at the National Ignition Facility (NIF).

    Science.gov (United States)

    Frenje, J A; Hilsabeck, T J; Wink, C W; Bell, P; Bionta, R; Cerjan, C; Gatu Johnson, M; Kilkenny, J D; Li, C K; Séguin, F H; Petrasso, R D

    2016-11-01

    The next-generation magnetic recoil spectrometer for time-resolved measurements of the neutron spectrum has been conceptually designed for the National Ignition Facility. This spectrometer, called MRSt, represents a paradigm shift in our thinking about neutron spectrometry for inertial confinement fusion applications, as it will provide simultaneously information about the burn history and time evolution of areal density (ρR), apparent ion temperature (T i ), yield (Y n ), and macroscopic flows during burn. From this type of data, an assessment of the evolution of the fuel assembly, hotspot, and alpha heating can be made. According to simulations, the MRSt will provide accurate data with a time resolution of ∼20 ps and energy resolution of ∼100 keV for total neutron yields above ∼10 16 . At lower yields, the diagnostic will be operated at a higher-efficiency, lower-energy-resolution mode to provide a time resolution of ∼20 ps.

  10. Measuring the absolute deuterium-tritium neutron yield using the magnetic recoil spectrometer at OMEGA and the NIF.

    Science.gov (United States)

    Casey, D T; Frenje, J A; Gatu Johnson, M; Séguin, F H; Li, C K; Petrasso, R D; Glebov, V Yu; Katz, J; Knauer, J P; Meyerhofer, D D; Sangster, T C; Bionta, R M; Bleuel, D L; Döppner, T; Glenzer, S; Hartouni, E; Hatchett, S P; Le Pape, S; Ma, T; MacKinnon, A; McKernan, M A; Moran, M; Moses, E; Park, H-S; Ralph, J; Remington, B A; Smalyuk, V; Yeamans, C B; Kline, J; Kyrala, G; Chandler, G A; Leeper, R J; Ruiz, C L; Cooper, G W; Nelson, A J; Fletcher, K; Kilkenny, J; Farrell, M; Jasion, D; Paguio, R

    2012-10-01

    A magnetic recoil spectrometer (MRS) has been installed and extensively used on OMEGA and the National Ignition Facility (NIF) for measurements of the absolute neutron spectrum from inertial confinement fusion implosions. From the neutron spectrum measured with the MRS, many critical implosion parameters are determined including the primary DT neutron yield, the ion temperature, and the down-scattered neutron yield. As the MRS detection efficiency is determined from first principles, the absolute DT neutron yield is obtained without cross-calibration to other techniques. The MRS primary DT neutron measurements at OMEGA and the NIF are shown to be in excellent agreement with previously established yield diagnostics on OMEGA, and with the newly commissioned nuclear activation diagnostics on the NIF.

  11. Proton magnetic resonance spectroscopy in schizophrenia

    International Nuclear Information System (INIS)

    Bertolino, Alessandro; Weinberger, Daniel R.

    1999-01-01

    Proton magnetic resonance spectroscopy (MRS) has become an important tool to study in vivo certain biochemical aspects of brain disorders. In the last decade this technique has been applied to the in vivo investigation of pathophysiological aspects of psychiatric disorders, extending knowledge of the related brain alterations. This review will focus on providing some background to clarify technical and biochemical issues and it will describe the studies that have been performed in schizophrenia. The results will be framed in a more general context to highlight what we have learned and what remains to be understood from the application of this technique to schizophrenia

  12. Porphyrin Protonation Studied by Magnetic Circular Dichroism

    Czech Academy of Sciences Publication Activity Database

    Štěpánek, Petr; Andrushchenko, Valery; Ruud, K.; Bouř, Petr

    2012-01-01

    Roč. 116, č. 1 (2012), s. 778-783 ISSN 1089-5639 R&D Projects: GA ČR GAP208/11/0105; GA ČR GA203/09/2037; GA ČR GAP208/10/0559; GA MŠk(CZ) LH11033 Institutional research plan: CEZ:AV0Z40550506 Keywords : magnetic circular dichroism ( MCD ) * TPPS * spectra simulations * porphyrin protonation Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 2.771, year: 2012

  13. Recoil properties of antimony isotopes produced by the reaction of 570 MeV and 18.2 GeV protons with uranium

    CERN Document Server

    Hagebø, E

    1969-01-01

    Using the method of thick target and thick catchers, the ranges and other recoil properties of 13 (12) antimony isotopes between A = 115 and A = 131 (130) have been measured for the reaction of 570 MeV (18·2 GeV) protons with uranium. The kinetic energies T are almost independent of product mass number at 570 MeV but show a strong dependence at 18·2 GeV, the lightest isotopes having only about half the kinetic energy of the heavy ones. \\\\ \\\\The cascade deposition energies for production of antimony isotopes are almost equal at 570 MeV and 18·2 GeV and fit well to straight lines of the form E$^{∗}$ (A, Z) = E$^{∗}$ (A$_{0}$, Z) + b(A − A$_{0}$). Exceptions are the cascade deposition energies for $^{115}$Sb and $^{116}$Sb which seem to be somewhat too high at 18·2 GeV. By comparison with other work it seems that the slope $b$ of these lines is independent of product element, target and of proton irradiation energy above 450 MeV. \\\\ \\\\If we assume at 570 MeV, that the fissioning nucleus is a uranium ...

  14. Proton magnetic resonance spectroscopy in the fetus.

    Science.gov (United States)

    Story, Lisa; Damodaram, Mellisa S; Allsop, Joanna M; McGuinness, Amy; Wylezinska, Marzena; Kumar, Sailesh; Rutherford, Mary A

    2011-09-01

    Magnetic Resonance Imaging (MRI) has become an established technique in fetal medicine, providing complementary information to ultrasound in studies of the brain. MRI can provide detailed structural information irrespective of the position of the fetal head or maternal habitus. Proton Magnetic Resonance Spectroscopy ((1)HMRS) is based on the same physical principles as MRI but data are collected as a spectrum, allowing the biochemical and metabolic status of in vivo tissue to be studied in a non-invasive manner. (1)HMRS has been used to assess metabolic function in the neonatal brain but fetal studies have been limited, primarily due to fetal motion. This review will assess the technique and findings from fetal studies to date. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  15. Strange magnetism and the anapole structure of the proton

    International Nuclear Information System (INIS)

    Hasty, R.; Beck, D.H.; Danagoulian, A.; Blake, A.; Carr, R.; Covrig, S.; Filipoone, B.W.; Ito, T.M.; Gao, J.; Jones, C.E.; Lee, P.; McKeown, R.D.; Savu, V.; Beise, E.J.; Breuer, H.; Spayde, D.T.; Tieulent, R.; Herda, M.C.; Barkhuff, D.; Dodson, G.; Dow, K.; Farkhondeh, M.; Kowalski, S.; Tsentalovich, E.; Yang, B.; Zwart, T.; Hawthorne-Allen, A.M.; Pitt, M.; Ritter, J.; Korsch, W.; Mueller, B.; Wells, S.P.; Averett, T.; Roche, J.; Kramer, K.

    2000-01-01

    The violation of mirror symmetry in the weak force provides a powerful tool to study the internal structure of the proton. Experimental results have been obtained that address the role of strange quarks in generating nuclear magnetism. The measurement reported here provides an unambiguous constraint on strange quark contributions to the proton's magnetic moment through the electron-proton weak interaction. We also report evidence for the existence of a parity-violating electromagnetic effect known as the anapole moment of the proton. The proton's anapole moment is not yet well understood theoretically, but it could have important implications for precision weak interaction studies in atomic systems such as cesium.

  16. Energy calibration for the INDRA multidetector using recoil protons from {sup 12}C+{sup 1}H scattering

    Energy Technology Data Exchange (ETDEWEB)

    Trzcinski, A.; Lukasik, J.; Mueller, W.F.J.; Trautmann, W.; Zwieglinski, B. E-mail: bzw@fuw.edu.pl; Auger, G.; Bacri, Ch.O.; Begemann-Blaich, M.L.; Bellaize, N.; Bittiger, R.; Bocage, F.; Borderie, B.; Bougault, R.; Bouriquet, B.; Buchet, Ph.; Charvet, J.L.; Chbihi, A.; Dayras, R.; Dore, D.; Durand, D.; Frankland, J.D.; Galichet, E.; Gourio, D.; Guinet, D.; Hudan, S.; Hurst, B.; Lautesse, P.; Lavaud, F.; Laville, J.L.; Leduc, C.; Le Fevre, A.; Legrain, R.; Lopez, O.; Lynen, U.; Nalpas, L.; Orth, H.; Plagnol, E.; Rosato, E.; Saija, A.; Schwarz, C.; Sfienti, C.; Steckmeyer, J.C.; Tabacaru, G.; Tamain, B.; Turzo, K.; Vient, E.; Vigilante, M.; Volant, C

    2003-04-01

    An efficient method of energy scale calibration for the CsI(Tl) modules of the INDRA multidetector (rings 6-12) using elastic and inelastic {sup 12}C+{sup 1}H scattering at E({sup 12}C)=30 MeV per nucleon is presented. Background-free spectra for the binary channels are generated by requiring the coincident detection of the light and heavy ejectiles. The gain parameter of the calibration curve is obtained by fitting the proton total charge spectra to the spectra predicted with Monte-Carlo simulations using tabulated cross section data. The method has been applied in multifragmentation experiments with INDRA at GSI.

  17. Energy calibration for the INDRA multidetector using recoil protons from sup 1 sup 2 C+ sup 1 H scattering

    CERN Document Server

    Trzcinski, A; Müller, W F J; Trautmann, W; Zwieglinski, B; Auger, G; Bacri, C O; Begemann-Blaich, M L; Bellaize, N; Bittiger, R; Bocage, F; Borderie, B; Bougault, R; Bouriquet, B; Buchet, P; Charvet, J L; Chbihi, A; Dayras, R; Doré, D; Durand, D; Frankland, J D; Galíchet, E; Gourio, D; Guinet, D; Hudan, S; Hurst, B; Lautesse, P; Lavaud, F; Laville, J L; Leduc, C; Lefèvre, A; Legrain, R; López, O; Lynen, U; Nalpas, L; Orth, H; Plagnol, E; Rosato, E; Saija, A; Schwarz, C; Sfienti, C; Steckmeyer, J C; Tabacaru, G; Tamain, B; Turzó, K; Vient, E; Vigilante, M; Volant, C

    2003-01-01

    An efficient method of energy scale calibration for the CsI(Tl) modules of the INDRA multidetector (rings 6-12) using elastic and inelastic sup 1 sup 2 C+ sup 1 H scattering at E( sup 1 sup 2 C)=30 MeV per nucleon is presented. Background-free spectra for the binary channels are generated by requiring the coincident detection of the light and heavy ejectiles. The gain parameter of the calibration curve is obtained by fitting the proton total charge spectra to the spectra predicted with Monte-Carlo simulations using tabulated cross section data. The method has been applied in multifragmentation experiments with INDRA at GSI.

  18. Observational limits on the magnetic-monopole structure of protons

    International Nuclear Information System (INIS)

    Broderick, J.J.; Ficenec, J.R.; Teplitz, D.C.; Teplitz, V.L.

    1979-01-01

    We report the results of a search for absorption of 42-cm radiation in neutral galactic hydrogen. One explanation of a positive result would be the existence of a type of anomalous proton whose magnetic moment arises from a distribution of magnetic charge rather than from a distribution of circulating currents. No absorption of 42-cm radiation was seen; this implies an upper limit of 2.3 x 10 -4 for the abundance of this type of anomalous proton relative to protons which radiate at 21 cm. The observed absence of anomalous protons also implies an absence of primordial anomalous protons since they could not have been swept up by heavier elements during cosmic nucleosynthesis. The observation is sensitive only to anomalous protons with exactly the same value for their magnetic moment that conventional ones have

  19. Combined proton-recoil and neutron time-of-flight spectrometer for 14 MeV neutrons

    International Nuclear Information System (INIS)

    Grosshoeg, G.; Aronsson, D.; Arvidsson, E.; Beimer, K.-H.; Pekkari, L.-O.; Rydz, R.; Sjoestrand, N.G.

    1983-05-01

    The main effort put into this work is the foundation of a reliable physical basis for a 12-16 MeV neutron-spectrometer at JET. The essential problem is the amount of scatterer that can be incorporated without losing resolution. We have found two possible methods, the use of a pure hydrogen scatterer and the use of a polyethylene foil scatterer. The pure hydrogen solution gives a very complicated spectrometer with large detectors. The polyethylene solution is limited by the thickness and the width of the foil. We judge the solution with the polyethylene foil to be the most promising one for a reliable spectrometer. However, a large foil area is needed. This gives a spectrometer design with an annular foil, an annular neutron detection system, and a central proton-detector. An efficiency of 10 - 6 counts/s per n/cm 2 ,s at the foil can be obtained with a resolution in the order of 100 keV for 14 MeV neutrons. Following the General Requirements given in the contract of this work, we concluded that an instrument with the desired properties can be made. The instruments is able to give useful information about the plasma from plasma temperatures of about 5 keV. (Authors)

  20. Measurements of the deuteron and proton magnetic form factors at large momentum transfers

    International Nuclear Information System (INIS)

    Bosted, P.E.; Katramatou, A.T.; Arnold, R.G.; Benton, D.; Clogher, L.; DeChambrier, G.; Lambert, J.; Lung, A.; Petratos, G.G.; Rahbar, A.; Rock, S.E.; Szalata, Z.M.; Debebe, B.; Frodyma, M.; Hicks, R.S.; Hotta, A.; Peterson, G.A.; Gearhart, R.A.; Alster, J.; Lichtenstadt, J.; Dietrich, F.; van Bibber, K.

    1990-01-01

    Measurements of the deuteron elastic magnetic structure function B(Q 2 ) are reported at squared four-momentum transfer values 1.20≤Q 2 ≤2.77 (GeV/c) 2 . Also reported are values for the proton magnetic form factor G Mp (Q 2 ) at 11 Q 2 values between 0.49 and 1.75 (GeV/c) 2 . The data were obtained using an electron beam of 0.5 to 1.3 GeV. Electrons backscattered near 180 degree were detected in coincidence with deuterons or protons recoiling near 0 degree in a large solid-angle double-arm spectrometer system. The data for B(Q 2 ) are found to decrease rapidly from Q 2 =1.2 to 2 (GeV/c) 2 , and then rise to a secondary maximum around Q 2 =2.5 (GeV/c) 2 . Reasonable agreement is found with several different models, including those in the relativistic impulse approximation, nonrelativistic calculations that include meson-exchange currents, isobar configurations, and six-quark configurations, and one calculation based on the Skyrme model. All calculations are very sensitive to the choice of deuteron wave function and nucleon form factor parametrization. The data for G Mp (Q 2 ) are in good agreement with the empirical dipole fit

  1. Programmable Power Supply for AC Switching Magnet of Proton Accelerator

    CERN Document Server

    Jeong, Seong-Hun; Kang Heung Sik; Lee, Chi-Hwan; Lee, Hong-Gi; Park, Ki-Hyeon; Ryu, Chun-Kil; Sik Han, Hong; Suck Suh, Hyung

    2005-01-01

    The 100-MeV PEFP proton linac has two proton beam extraction lines for user' experiment. Each extraction line has 5 beamlines and has 5 Hz operating frequency. An AC switching magnet is used to distribute the proton beam to the 5 beamlines, An AC switching magnet is powered by PWM-controlled bipolar switching-mode converters. This converter is designed to operate at ±350A, 5 Hz programmable step output. The power supply is employed IGBT module and has controlled by a DSP (Digital Signal Process). This paper describes the design and test results of the power supply.

  2. High-resolution measurements of the DT neutron spectrum using new CD foils in the Magnetic Recoil neutron Spectrometer (MRS) on the National Ignition Facility

    Energy Technology Data Exchange (ETDEWEB)

    Gatu Johnson, M., E-mail: gatu@psfc.mit.edu; Frenje, J. A.; Li, C. K.; Petrasso, R. D.; Séguin, F. H. [Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Bionta, R. M.; Casey, D. T.; Eckart, M. J.; Grim, G. P.; Hartouni, E. P.; Hatarik, R.; Sayre, D. B.; Skulina, K.; Yeamans, C. B. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); Farrell, M. P.; Hoppe, M.; Kilkenny, J. D.; Reynolds, H. G.; Schoff, M. E. [General Atomics, San Diego, California 92186 (United States)

    2016-11-15

    The Magnetic Recoil neutron Spectrometer (MRS) on the National Ignition Facility measures the DT neutron spectrum from cryogenically layered inertial confinement fusion implosions. Yield, areal density, apparent ion temperature, and directional fluid flow are inferred from the MRS data. This paper describes recent advances in MRS measurements of the primary peak using new, thinner, reduced-area deuterated plastic (CD) conversion foils. The new foils allow operation of MRS at yields 2 orders of magnitude higher than previously possible, at a resolution down to ∼200 keV FWHM.

  3. Sensitive detection of hydrogen in a-Si:H by coincidence measurement of elastically scattered 100 MeV /sup 3/He/sup 2 +/ ions and recoil protons

    Energy Technology Data Exchange (ETDEWEB)

    Fukada, Noboru; Imura, Takeshi; Hiraki, Akio [Osaka Univ., Suita (Japan). Faculty of Engineering; Itahashi, Takahisa; Fukuda, Tomokazu; Tanaka, Masayoshi

    1982-09-01

    We have drastically improved the sensitivity of the nuclear elastic scattering (NES) method for determining hydrogen concentrations in hydrogenated amorphous silicon (a-Si:H) films. A beam of 100 MeV /sup 3/He/sup 2 +/ ions was used in the experiment. By taking the coincidence of detection of the scattered /sup 3/He ion with that of the recoil proton, we could achieve a sensitivity of 0.1 atomic percent with a precision of about 1 percent for 1 ..mu..m films.

  4. Determination of lifetimes of nuclear excited states using the Recoil Distance Doppler Shift Method in combination with magnetic spectrometers

    Energy Technology Data Exchange (ETDEWEB)

    Doncel, M. [Universidad de Salamanca, Laboratorio de Radiaciones Ionizantes, Salamanca (Spain); Royal Institute of Technology, Department of Physics, Stockholm (Sweden); University of Liverpool, Department of Physics, Oliver Lodge Laboratory, Liverpool (United Kingdom); Gadea, A. [CSIC-University of Valencia, Istituto de Fisica Corpuscular, Valencia (Spain); Valiente-Dobon, J.J. [INFN, Laboratori Nazionali di Legnaro, Legnaro (Italy); Quintana, B. [Universidad de Salamanca, Laboratorio de Radiaciones Ionizantes, Salamanca (Spain); Modamio, V. [INFN, Laboratori Nazionali di Legnaro, Legnaro (Italy); University of Oslo, Oslo (Norway); Mengoni, D. [Dipartimento di Fisica e Astronomia, Universita di Padova, Padova (Italy); Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Padova (Italy); Moeller, O.; Pietralla, N. [Technische Universitaet Darmstadt, Institut fuer Kernphysik, Darmstadt (Germany); Dewald, A. [Institut fuer Kernphysik, Universitaet Koeln (Germany)

    2017-10-15

    The current work presents the determination of lifetimes of nuclear excited states using the Recoil Distance Doppler Shift Method, in combination with spectrometers for ion identification, normalizing the intensity of the peaks by the ions detected in the spectrometer as a valid technique that produces results comparable to the ones obtained by the conventional shifted-to-unshifted peak ratio method. The technique has been validated using data measured with the γ-ray array AGATA, the PRISMA spectrometer and the Cologne plunger setup. In this paper a test performed with the AGATA-PRISMA setup at LNL and the advantages of this new approach with respect to the conventional Recoil Distance Doppler Shift Method are discussed. (orig.)

  5. Parity Violation in Elastic Electron-Proton Scattering and the Proton's Strange Magnetic Form Factor

    International Nuclear Information System (INIS)

    Spayde, D. T.; Averett, T.; Barkhuff, D.; Beck, D. H.; Beise, E. J.; Benson, C.; Breuer, H.; Carr, R.; Covrig, S.; DelCorso, J.

    2000-01-01

    We report a new measurement of the parity-violating asymmetry in elastic electron scattering from the proton at backward scattering angles. This asymmetry is sensitive to the strange magnetic form factor of the proton as well as electroweak axial radiative corrections. The new measurement of A=-4.92±0.61±0.73 ppm provides a significant constraint on these quantities. The implications for the strange magnetic form factor are discussed in the context of theoretical estimates for the axial corrections. (c) 2000 The American Physical Society

  6. Magnetic properties of point defects in proton irradiated diamond

    Energy Technology Data Exchange (ETDEWEB)

    Makgato, T.N., E-mail: Thuto.Makgato@students.wits.ac.za [School of Physics, University of the Witwatersrand, Johannesburg 2050 (South Africa); Sideras-Haddad, E. [School of Physics, University of the Witwatersrand, Johannesburg 2050 (South Africa); Center of Excellence in Strong Materials, Physics Building, University of the Witwatersrand, Johannesburg 2050 (South Africa); Ramos, M.A. [CMAM, Centro de Micro-Analisis de Materiales, Universidad Autónoma de Madrid, C/Faraday 3, Campus de Cantoblanco, E-28049 Madrid (Spain); Departamento de Fisica de la Materia Condensada, Condensed Matter Physics Center (IFIMAC) and Instituto Nicolás Cabrera, Universidad Autónoma de Madrid, 28049 Madrid (Spain); García-Hernández, M. [Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, E-28049 Madrid (Spain); Climent-Font, A.; Zucchiatti, A.; Muñoz-Martin, A. [CMAM, Centro de Micro-Analisis de Materiales, Universidad Autónoma de Madrid, C/Faraday 3, Campus de Cantoblanco, E-28049 Madrid (Spain); Shrivastava, S. [School of Physics, University of the Witwatersrand, Johannesburg 2050 (South Africa); Erasmus, R. [School of Physics, University of the Witwatersrand, Johannesburg 2050 (South Africa); Center of Excellence in Strong Materials, Physics Building, University of the Witwatersrand, Johannesburg 2050 (South Africa)

    2016-09-01

    We investigate the magnetic properties of ultra-pure type-IIa diamond following irradiation with proton beams of ≈1–2 MeV energy. SQUID magnetometry indicate the formation of Curie type paramagnetism according to the Curie law. Raman and Photoluminescence spectroscopy measurements show that the primary structural features created by proton irradiation are the centers: GR1, ND1, TR12 and 3H. The Stopping and Range of Ions in Matter (SRIM) Monte Carlo simulations together with SQUID observations show a strong correlation between vacancy production, proton fluence and the paramagnetic factor. At an average surface vacancy spacing of ≈1–1.6 nm and bulk (peak) vacancy spacing of ≈0.3-0.5 nm Curie paramagnetism is induced by formation of ND1 centres with an effective magnetic moment μ{sub eff}~(0.1–0.2)μ{sub B}. No evidence of long range magnetic ordering is observed in the temperature range 4.2-300 K. - Highlights: • Proton macro-irradiation of pure diamond creates fluence dependent paramagnetism. • The effective magnetic moment is found to be in the range μ{sub eff}~(0.1–0.2)μ{sub B}. • No evidence of long range magnetic ordering is observed.

  7. Magnetic properties of point defects in proton irradiated diamond

    International Nuclear Information System (INIS)

    Makgato, T.N.; Sideras-Haddad, E.; Ramos, M.A.; García-Hernández, M.; Climent-Font, A.; Zucchiatti, A.; Muñoz-Martin, A.; Shrivastava, S.; Erasmus, R.

    2016-01-01

    We investigate the magnetic properties of ultra-pure type-IIa diamond following irradiation with proton beams of ≈1–2 MeV energy. SQUID magnetometry indicate the formation of Curie type paramagnetism according to the Curie law. Raman and Photoluminescence spectroscopy measurements show that the primary structural features created by proton irradiation are the centers: GR1, ND1, TR12 and 3H. The Stopping and Range of Ions in Matter (SRIM) Monte Carlo simulations together with SQUID observations show a strong correlation between vacancy production, proton fluence and the paramagnetic factor. At an average surface vacancy spacing of ≈1–1.6 nm and bulk (peak) vacancy spacing of ≈0.3-0.5 nm Curie paramagnetism is induced by formation of ND1 centres with an effective magnetic moment μ eff ~(0.1–0.2)μ B . No evidence of long range magnetic ordering is observed in the temperature range 4.2-300 K. - Highlights: • Proton macro-irradiation of pure diamond creates fluence dependent paramagnetism. • The effective magnetic moment is found to be in the range μ eff ~(0.1–0.2)μ B . • No evidence of long range magnetic ordering is observed.

  8. Mercury's Surface Magnetic Field Determined from Proton-Reflection Magnetometry

    Science.gov (United States)

    Winslow, Reka M.; Johnson, Catherine L.; Anderson, Brian J.; Gershman, Daniel J.; Raines, Jim M.; Lillis, Robert J.; Korth, Haje; Slavin, James A.; Solomon, Sean C.; Zurbuchen, Thomas H.; hide

    2014-01-01

    Solar wind protons observed by the MESSENGER spacecraft in orbit about Mercury exhibit signatures of precipitation loss to Mercury's surface. We apply proton-reflection magnetometry to sense Mercury's surface magnetic field intensity in the planet's northern and southern hemispheres. The results are consistent with a dipole field offset to the north and show that the technique may be used to resolve regional-scale fields at the surface. The proton loss cones indicate persistent ion precipitation to the surface in the northern magnetospheric cusp region and in the southern hemisphere at low nightside latitudes. The latter observation implies that most of the surface in Mercury's southern hemisphere is continuously bombarded by plasma, in contrast with the premise that the global magnetic field largely protects the planetary surface from the solar wind.

  9. The n,{gamma} discrimination in recoil-proton proportional counters. Application to the measurement of fast neutron spectra; Discrimination n,{gamma} dans les compteurs proportionnels a protons de recul. Application a la mesure des spectres de neutrons rapides

    Energy Technology Data Exchange (ETDEWEB)

    Jeandidier, C [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    A description is given of a spectrometry chain working in the energy range of a few keV to 1 MeV, and designed for measurement of fast neutron spectra. It consists of detectors, recoil proton proportional counters built especially for this work by R. COMTE (DEG/SER) and which make it possible to cover the energy range and also associated electronic equipment. A brief description is first given of the physical processes involved: (n,p) collisions in the gas, influence of {gamma} radiation; the method of discrimination is then presented. It is based on the difference in the rise-times of the pulses. In the experiments described here the use of a bi-parametric system made it possible to employ the most simple discrimination device, based on the fact that the high frequency gamma pulse components are, at a given energy, weaker than those of the neutron pulses. Results are given of measurements carried out on the Van der Graaff (mono-energetic neutrons for testing the linearity of the chain and the resolving power of the counters), and of those made in a sub-critical system Hug at Cadarache. (author) [French] On decrit une chaine de spectrometrie travaillant dans le domaine d'energie de quelques keV a 1 MeV destinee a la mesure des spectres de neutrons rapides. Elle comprend les detecteurs, compteurs proportionnels a protons de recul, realises specialement pour cette etude par M. R. COMTE (DEG/SER), permettant de couvrir la gamme d'energie et l'electronique associee. Apres un rappel des processus physiques mis en jeu: chocs (n,p) dans les gaz, influence des rayonnements {gamma}, on expose la methode de discrimination utilisee. Celle-ci est basee sur la difference des temps de montee des impulsions. Au cours des experiences rapportees ici, la mise en oeuvre d'un ensemble bi-parametrique a permis d'utiliser le dispositif de discrimination le plus simple, base sur la remarque que les composantes a haute frequence des impulsions {gamma} sont, a energie egale, plus faibles

  10. The n,{gamma} discrimination in recoil-proton proportional counters. Application to the measurement of fast neutron spectra; Discrimination n,{gamma} dans les compteurs proportionnels a protons de recul. Application a la mesure des spectres de neutrons rapides

    Energy Technology Data Exchange (ETDEWEB)

    Jeandidier, C. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    A description is given of a spectrometry chain working in the energy range of a few keV to 1 MeV, and designed for measurement of fast neutron spectra. It consists of detectors, recoil proton proportional counters built especially for this work by R. COMTE (DEG/SER) and which make it possible to cover the energy range and also associated electronic equipment. A brief description is first given of the physical processes involved: (n,p) collisions in the gas, influence of {gamma} radiation; the method of discrimination is then presented. It is based on the difference in the rise-times of the pulses. In the experiments described here the use of a bi-parametric system made it possible to employ the most simple discrimination device, based on the fact that the high frequency gamma pulse components are, at a given energy, weaker than those of the neutron pulses. Results are given of measurements carried out on the Van der Graaff (mono-energetic neutrons for testing the linearity of the chain and the resolving power of the counters), and of those made in a sub-critical system Hug at Cadarache. (author) [French] On decrit une chaine de spectrometrie travaillant dans le domaine d'energie de quelques keV a 1 MeV destinee a la mesure des spectres de neutrons rapides. Elle comprend les detecteurs, compteurs proportionnels a protons de recul, realises specialement pour cette etude par M. R. COMTE (DEG/SER), permettant de couvrir la gamme d'energie et l'electronique associee. Apres un rappel des processus physiques mis en jeu: chocs (n,p) dans les gaz, influence des rayonnements {gamma}, on expose la methode de discrimination utilisee. Celle-ci est basee sur la difference des temps de montee des impulsions. Au cours des experiences rapportees ici, la mise en oeuvre d'un ensemble bi-parametrique a permis d'utiliser le dispositif de discrimination le plus simple, base sur la remarque que les composantes a haute frequence des impulsions {gamma} sont, a

  11. A magnetically switched kicker for proton extraction

    International Nuclear Information System (INIS)

    Dinkel, J.; Biggs, J.

    1989-03-01

    The application of magnetic current amplification and switching techniques to the generation of precise high current pulses for switching magnets is described. The square loop characteristic of Metglas tape wound cores at high excitation levels provides excellent switching characteristics for microsecond pulses. The rugged and passive nature of this type pulser makes it possible to locate the final stages of amplification at the load for maximum efficiency. 12 refs., 8 figs

  12. The coincidence counting technique for orders of magnitude background reduction in data obtained with the magnetic recoil spectrometer at OMEGA and the NIF

    International Nuclear Information System (INIS)

    Casey, D. T.; Frenje, J. A.; Seguin, F. H.; Li, C. K.; Rosenberg, M. J.; Rinderknecht, H.; Manuel, M. J.-E.; Gatu Johnson, M.; Schaeffer, J. C.; Frankel, R.; Sinenian, N.; Childs, R. A.; Petrasso, R. D.; Glebov, V. Yu.; Sangster, T. C.; Burke, M.; Roberts, S.

    2011-01-01

    A magnetic recoil spectrometer (MRS) has been built and successfully used at OMEGA for measurements of down-scattered neutrons (DS-n), from which an areal density in both warm-capsule and cryogenic-DT implosions have been inferred. Another MRS is currently being commissioned on the National Ignition Facility (NIF) for diagnosing low-yield tritium-hydrogen-deuterium implosions and high-yield DT implosions. As CR-39 detectors are used in the MRS, the principal sources of background are neutron-induced tracks and intrinsic tracks (defects in the CR-39). The coincidence counting technique was developed to reduce these types of background tracks to the required level for the DS-n measurements at OMEGA and the NIF. Using this technique, it has been demonstrated that the number of background tracks is reduced by a couple of orders of magnitude, which exceeds the requirement for the DS-n measurements at both facilities.

  13. Measurements of fuel and ablator ρR in Symmetry-Capsule implosions with the Magnetic Recoil neutron Spectrometer (MRS) on the National Ignition Facility

    Energy Technology Data Exchange (ETDEWEB)

    Gatu Johnson, M., E-mail: gatu@psfc.mit.edu; Frenje, J. A.; Li, C. K.; Séguin, F. H.; Petrasso, R. D. [Plasma Science and Fusion Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Bionta, R. M.; Casey, D. T.; Caggiano, J. A.; Hatarik, R.; Khater, H. Y.; Sayre, D. B. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); Knauer, J. P.; Sangster, T. C. [Laboratory for Laser Energetics, University of Rochester, Rochester, New York 14623 (United States); Herrmann, H. W. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Kilkenny, J. D. [General Atomics, San Diego, California 92186 (United States)

    2014-11-15

    The Magnetic Recoil neutron Spectrometer (MRS) on the National Ignition Facility (NIF) measures the neutron spectrum in the energy range of 4–20 MeV. This paper describes MRS measurements of DT-fuel and CH-ablator ρR in DT gas-filled symmetry-capsule implosions at the NIF. DT-fuel ρR's of 80–140 mg/cm{sup 2} and CH-ablator ρR's of 400–680 mg/cm{sup 2} are inferred from MRS data. The measurements were facilitated by an improved correction of neutron-induced background in the low-energy part of the MRS spectrum. This work demonstrates the accurate utilization of the complete MRS-measured neutron spectrum for diagnosing NIF DT implosions.

  14. The coincidence counting technique for orders of magnitude background reduction in data obtained with the magnetic recoil spectrometer at OMEGA and the NIF.

    Science.gov (United States)

    Casey, D T; Frenje, J A; Séguin, F H; Li, C K; Rosenberg, M J; Rinderknecht, H; Manuel, M J-E; Gatu Johnson, M; Schaeffer, J C; Frankel, R; Sinenian, N; Childs, R A; Petrasso, R D; Glebov, V Yu; Sangster, T C; Burke, M; Roberts, S

    2011-07-01

    A magnetic recoil spectrometer (MRS) has been built and successfully used at OMEGA for measurements of down-scattered neutrons (DS-n), from which an areal density in both warm-capsule and cryogenic-DT implosions have been inferred. Another MRS is currently being commissioned on the National Ignition Facility (NIF) for diagnosing low-yield tritium-hydrogen-deuterium implosions and high-yield DT implosions. As CR-39 detectors are used in the MRS, the principal sources of background are neutron-induced tracks and intrinsic tracks (defects in the CR-39). The coincidence counting technique was developed to reduce these types of background tracks to the required level for the DS-n measurements at OMEGA and the NIF. Using this technique, it has been demonstrated that the number of background tracks is reduced by a couple of orders of magnitude, which exceeds the requirement for the DS-n measurements at both facilities.

  15. The magnetic moments of the proton and the antiproton

    CERN Document Server

    Ulmer, S.; Blaum, K.; Braeuninger, S.; Franke, K.; Kracke, H.; Leiteritz, C.; Matsuda, Y.; Nagahama, H.; Ospelkaus, C.; Rodegheri, C.C.; Quint, W.; Schneider, G.; Smorra, C.; Van Gorp, S.; Walz, J.; Yamazaki, Y.

    2014-01-01

    Recent exciting progress in the preparation and manipulation of the motional quantum states of a single trapped proton enabled the first direct detection of the particle's spin state. Based on this success the proton magnetic moment $\\mu_p$ was measured with ppm precision in a Penning trap with a superimposed magnetic field inhomogeneity. An improvement by an additional factor of 1000 in precision is possible by application of the so-called double Penning trap technique. In a recent paper we reported the first demonstration of this method with a single trapped proton, which is a major step towards the first direct high-precision measurement of $\\mu_p$. The techniques required for the proton can be directly applied to measure the antiproton magnetic moment $\\mu_{\\bar{p}}$. An improvement in precision of $\\mu_{\\bar{p}}$ by more than three orders of magnitude becomes possible, which will provide one of the most sensitive tests of CPT invariance. To achieve this research goal we are currently setting up the Baryo...

  16. Experimental validation of a Monte Carlo proton therapy nozzle model incorporating magnetically steered protons

    International Nuclear Information System (INIS)

    Peterson, S W; Polf, J; Archambault, L; Beddar, S; Bues, M; Ciangaru, G; Smith, A

    2009-01-01

    The purpose of this study is to validate the accuracy of a Monte Carlo calculation model of a proton magnetic beam scanning delivery nozzle developed using the Geant4 toolkit. The Monte Carlo model was used to produce depth dose and lateral profiles, which were compared to data measured in the clinical scanning treatment nozzle at several energies. Comparisons were also made between measured and simulated off-axis profiles to test the accuracy of the model's magnetic steering. Comparison of the 80% distal dose fall-off values for the measured and simulated depth dose profiles agreed to within 1 mm for the beam energies evaluated. Agreement of the full width at half maximum values for the measured and simulated lateral fluence profiles was within 1.3 mm for all energies. The position of measured and simulated spot positions for the magnetically steered beams agreed to within 0.7 mm of each other. Based on these results, we found that the Geant4 Monte Carlo model of the beam scanning nozzle has the ability to accurately predict depth dose profiles, lateral profiles perpendicular to the beam axis and magnetic steering of a proton beam during beam scanning proton therapy.

  17. Proton nuclear magnetic resonance imaging of regionally ischemic canine hearts: effects of paramagnetic proton signal enhancement

    International Nuclear Information System (INIS)

    Brady, T.J.; Goldman, M.R.; Pykett, I.L.; Buonanno, F.S.; Kistler, J.P.; Newhouse, J.H.; Burt, C.T.; Hinshaw, W.S.; Pohost, G.M.

    1982-01-01

    In a study to evaluate the potential of proton nuclear magnetic resonance (NMR) imaging with and without manganese contrast enhancement for detecting acute myocardial infarction, 12 dogs underwent 90-minute occlusion of the left circumflex coronary artery. Transverse-section NMR images of the excised, nonbeating heart were obtained at 1-cm intervals using the steady-state-free-precession (SSFP) technique. All NMR images revealed detailed structure of the heart. The three hearts without manganese showed no difference in intensity between the normal and the ischemic posterior regions, whereas those with manganese demonstrated a clearly demarcated zone of reduced signal intensity consistent with the ischemic zone. It is concluded that high-resolution tomograms of the excised canine myocardium can be obtained using proton NMR imaging. With the SSFP imaging technique, proton signal enhancement with manganese infusion is necessary to differentiate between ischemic and nonischemic myocardium after 90 minutes of coronary occlusion

  18. Effect of neutron and proton radiations on magnetization of biotite

    CERN Document Server

    Abdurakhimov, A U; Sharipov, S M; Yugaj, V P; Granovskij, A B; Radkovskaya, A A

    2002-01-01

    One analyzes curves of field dependence of magnetization of biotite measured in the initial state under 4.2 K temperature subsequent to irradiation of 14 MeV energy and 1.2 x 10 sup 1 sup 3 cm sup - sup 2 dose neutrons and by 3 MeV energy and 2.2 x 10 sup 1 sup 4 cm sup - sup 2 dose protons, as well as, subsequent to annealing under 1000 deg temperature during 15 min. Irradiation by neutrons and protons was determined to result in increase of magneto-ordered phase content in biotite and, thus, in increase of magnetization of specimen. It is accounted for by formation of oxides in melt radiation thermal peaks and by freezing of high-temperature phase states corresponding to magnetite or solid solution of magnetite and hematite there. Thermal treatment does not change content of magneto-ordered phase in specimens

  19. Hydrogen analysis by elastic recoil spectrometry

    International Nuclear Information System (INIS)

    Tirira, J.; Trocellier, P.

    1989-01-01

    An absolute, quantitative procedure was developed to determine the hydrogen content and to describe its concentration profile in the near-surface region of solids. The experimental technique used was the elastic recoil detection analysis of protons induced by 4 He beam bombardment in the energy range <=1.8 MeV. The hydrogen content was calculated using a new recoil cross section expression. The analyses were performed in silicon crystals implanted with hydrogen at 10 keV. The implantation dose was evaluated with an accuracy of 10% and the hydrogen depth profile with that of +-10 nm around 200 nm. (author) 10 refs.; 3 figs

  20. Superconducting Magnet Technology for Future High Energy Proton Colliders

    Science.gov (United States)

    Gourlay, Stephen

    2017-01-01

    Interest in high field dipoles has been given a boost by new proposals to build a high-energy proton-proton collider to follow the LHC and programs around the world are taking on the task to answer the need. Studies aiming toward future high-energy proton-proton colliders at the 100 TeV scale are now being organized. The LHC and current cost models are based on technology close to four decades old and point to a broad optimum of operation using dipoles with fields between 5 and 12T when site constraints, either geographical or political, are not a factor. Site geography constraints that limit the ring circumference can drive the required dipole field up to 20T, which is more than a factor of two beyond state-of-the-art. After a brief review of current progress, the talk will describe the challenges facing future development and present a roadmap for moving high field accelerator magnet technology forward. This work was supported by the Director, Office of Science, High Energy Physics, US Department of Energy, under contract No. DE-AC02-05CH11231.

  1. Clinical applications of proton magnetic resonance spectroscopy of the brain

    International Nuclear Information System (INIS)

    Laubenberger, J.; Bayer, S.; Thiel, T.; Hennig, J.; Langer, M.

    1998-01-01

    In spite of all the scientific advances of the past few years, proton magnetic resonance spectroscopy of the brain has not attained the status of a routine examination technique with clinically accepted indications. The method should be considered as an additional option to MR imaging for inherited and acquired encephalopathic changes as well as, in future, for localization diagnosis of epilepsies. A proton magnetic resonance spectroscopic investigation without a prior intensive clinical and imaging investigation is not useful. Above all, factors influencing metabolite distribution such as for example, serum osmolability must be known. Methodological prerequisites for the clinical application of proton resonance spectroscopy are, first of all, a high stability of the chosen technique as well as a sufficiently certain quantification of metabolites and the availability of a reference group. The use of short echo times is necessary for the quantification of glutamine and the osmolyte myo-inositol. Indications for individual cases in which clinical investigations and MR topography cannot provide sufficient certainty and spectroscopy can furnish additional information are, in addition to uses in neuropediatrics, the suspicion of Alzheimer's dementia, HIV encephalopathy in early manifestations, and unclarified depressions of consciousness accompanying liver cirrhosis. (orig.) [de

  2. On the importance of exchangeable NH protons in creatine for the magnetic coupling of creatine methyl protons in skeletal muscle

    NARCIS (Netherlands)

    Kruiskamp, M.J.; Nicolaij, K.

    2001-01-01

    The methyl protons of creatine in skeletal muscle exhibit a strong off-resonance magnetization transfer effect. The mechanism of this process is unknown. We previously hypothesized that the exchangeable amide/amino protons of creatine might be involved. To test this the characteristics of the

  3. Exclusive compton scattering on the proton

    International Nuclear Information System (INIS)

    Chen, J.P.; Chudakov, E.; DeJager, C.; Degtyarenko, P.; Ent, R.; Gomez, J.; Hansen, O.; Keppel, C.; Klein, F.; Kuss, M.

    1999-01-01

    An experiment is proposed to measure the cross sections for Real Compton Scattering from the proton in the energy range 3-6 GeV and over a wide angular range, and to measure the longitudinal and transverse components of the polarization transfer to the recoil proton at a single kinematic point. Together, these measurements will test models of the reaction mechanism and determine new structure functions of the proton that are related to the same non-forward parton densities that determine the elastic electron scattering form factors and the parton densities. The experiment utilizes an untagged Bremsstrahlung photon beam and the standard Hall A cryogenic targets. The scattered photon is detected in a photon spectrometer, currently under construction. The coincident recoil proton is detected in one of the Hall A magnetic spectrometers and its polarization components are measured in the existing Focal Plane Polarimeter. This proposal extends and supersedes E97 - 108 which was approved by PAC13. (author)

  4. Exclusive compton scattering on the proton

    Energy Technology Data Exchange (ETDEWEB)

    Chen, J.P.; Chudakov, E.; DeJager, C.; Degtyarenko, P.; Ent, R.; Gomez, J.; Hansen, O.; Keppel, C.; Klein, F.; Kuss, M. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)] [and others

    1999-07-01

    An experiment is proposed to measure the cross sections for Real Compton Scattering from the proton in the energy range 3-6 GeV and over a wide angular range, and to measure the longitudinal and transverse components of the polarization transfer to the recoil proton at a single kinematic point. Together, these measurements will test models of the reaction mechanism and determine new structure functions of the proton that are related to the same non-forward parton densities that determine the elastic electron scattering form factors and the parton densities. The experiment utilizes an untagged Bremsstrahlung photon beam and the standard Hall A cryogenic targets. The scattered photon is detected in a photon spectrometer, currently under construction. The coincident recoil proton is detected in one of the Hall A magnetic spectrometers and its polarization components are measured in the existing Focal Plane Polarimeter. This proposal extends and supersedes E97 - 108 which was approved by PAC13. (author)

  5. Exclusive Compton Scattering on the Proton

    International Nuclear Information System (INIS)

    Chen, J. P.; Chudakov, E.; DeJager, C.; Degtyarenko, P.; Ent, R.; Gomez, J.; Hansen, O.; Keppel, C.; Klein, F.; Kuss, M.; LeRose, J.; Liang, M.; Michaels, R.; Mitchell, J.; Liyanage, N.; Rutt, P.; Saha, A.; Wojtsekhowski, B.; Bouwhuis, M.; Chang, T.H.; Holt, R. J.; Nathan, A. M.; Roedelbronn, M.; Wijesooriya, K.; Williamson, S. E.; Dodge, G.; Hyde-Wright, C.; Radyushkin, A.; Sabatie, F.; Weinstein, L. B.; Ulmer, P.; Bosted, P.; Finn, J. M.; Jones, M.; Churchwell, S.; Howell, C.; Gilman, R.; Glashausser, C.; Jiang, X.; Ransome, R.; Strauch, S.; Berthot, J.; Bertin, P.; Fonvielle, H.; Roblin, Y.; Bertozzi, W.; Gilad, S.; Rowntree, D.; Zu, Z.; Brown, D.; Chang, G.; Afanasev, A.; Egiyan, K.; Hoohauneysan, E.; Ketikyan, A.; Mailyan, S.; Petrosyan, A.; Shahinyan, A.; Voskanyan, H.; Boeglin, W.; Markowitz, P.; Hines, J.; Strobel, G.; Templon, J.; Feldman, G.; Morris, C. L.; Gladyshev, V.; Lindgren, R. A.; Calarco, J.; Hersman, W.; Leuschner, M.; Gasparian, A.

    1999-01-01

    An experiment is proposed to measure the cross sections for Real Compton Scattering from the proton in the energy range 3-6 GeV and over a wide angular range; and to measure the longitudinal and transverse components of the polarization transfer to the recoil proton at a single kinematic point. Together; these measurements will test models of the reaction mechanism and determine new structure functions of the proton that are related to the same nonforward parton densities that determine the elastic electron scattering form factors and the parton densities. The experiment utilizes an untagged bremsstrahlung photon beam and the standard Hall A cryogenic targets. The scattered photon is detected in a photon spectrometer; currently under construction. The coincident recoil proton is detected in one of the Hall A magnetic spectrometers and its polarization components are measured in the existing Focal Plane Polarimeter. This proposal extends and supercedes E97-108 which was approved by PAC13

  6. Evaluation of human thyroid tumors by proton nuclear magnetic resonance

    International Nuclear Information System (INIS)

    deCertaines, J.; Herry, J.Y.; Lancien, G.; Benoist, L.; Bernard, A.M.; LeClech, G.

    1982-01-01

    Proton nuclear magnetic resonance (NMR) was used in a study of 40 patients with thyroid tumors following partial or total thyroidectomy. Three patient groups were considered: those with nodules showing increased uptake, those with solitary nodules with decreased uptake, and those with multinodular goiters. Spin-lattice and spin-spin relaxation times (T 1 and T 2 ) were measured on samples of nodular and extranodular tissue from each patient. Increased T 1 and T 2 were observed for benign cold nodules, an increase in T 1 alone for nodules with increased uptake, and a wide fluctuation in T 1 and T 2 for multinodular goiters. The four cancers in the series did not show a distinctive proton NMR pattern in comparison with the other nodular structures studied. The results point to the feasibility of applying NMR techniques to the detection of thyroid disease

  7. Proton magnetic resonance spectroscopy and perfusion magnetic resonance imaging in the evaluation of musculoskeletal tumors

    International Nuclear Information System (INIS)

    Costa, Flavia Martins; Setti, Marcela; Vianna, Evandro Miguelote; Domingues, Romulo Cortes; Meohas, Walter; Rezende, Jose Francisco; Gasparetto, Emerson Leandro

    2009-01-01

    Objective: To assess the role of proton magnetic resonance spectroscopy and dynamic contrast-enhanced magnetic resonance imaging in the differentiation between malignant and benign musculoskeletal tumors. Materials And Methods: Fifty-five patients with musculoskeletal tumors (27 malignant and 28 benign) were studied. The examinations were performed in a 1.5 T magnetic resonance scanner with standard protocol, and single voxel proton magnetic resonance spectroscopy with 135 msec echo time. The dynamic contrast study was performed using T1-weighted gradient-echo sequence after intravenous gadolinium injection. Time signal intensity curves and slope values were calculated. The statistical analysis was performed with the Levene's test, followed by a Student's t-test, besides the Pearson's chi-squared and Fischer's exact tests. Results: Proton magnetic resonance spectroscopy sensitivity, specificity and accuracy were, respectively, 87.5%, 92.3% and 90.9% (p < 0.0001). Statistically significant difference was observed in the slope (%/min) between benign (mean, 27.5%/min) and malignant (mean, 110.9%/min) lesions (p < 0.0001). Conclusion: The time-intensity curve and slope values using dynamic-enhanced perfusion magnetic resonance imaging in association with the presence of choline peak demonstrated by single voxel magnetic resonance spectroscopy study are useful in the differentiation between malignant and benign musculoskeletal tumors. (author)

  8. Magnetic moment of extremely proton-rich nucleus 23Al

    International Nuclear Information System (INIS)

    Nagatomo, T; Matsuta, K; Ozawa, A; Nakashima, Y; Matsumiya, R; Mihara, M; Yasuno, T; Chiba, A; Yamada, K; Momota; Ohtsubo, T; Ohta, M; Shinojima, D; Izumikawa, T; Tanaka, H; Yamaguchi, T; Nakajima, S; Maemura, H; Muranaka, K; Kumashiro, S; Fujiwara, H; Yoshida, K; Sumikama, T; Tanaka, K; Ogura, M; Minamisono, K; Fukuda, M; Minamisono, T; Nojiri, Y; Suzuki, T; Tanihata, I; Alonso, J R; Krebs, G F; Symons, T J M

    2005-01-01

    The g-factor of the extremely proton-rich nucleus 23 Al (T 1/2 = 0.47 s) has been measured by means of the β-NMR method for the first time. The g-factor were determined as |g| = 1.557(88) from the obtained NMR spectra. From the comparison between the experimental value and the shell model calculation, the spin parity of the ground state of 23 Al was determined as I π = 5/2 + . Thus, the magnetic moment of 23 Al was determined as vertical bar μvertical bar = 3.89(22)μ N

  9. Proton magnetic resonance spectroscopic imaging in neurodegenerative diseases

    International Nuclear Information System (INIS)

    Schuff, Norbert; Vermathen, Peter; Maudsley, Andrew A.; Weiner, Michael W.

    1999-01-01

    Proton magnetic resonance spectroscopic imaging ( 1 H MRSI) was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1 H MRSI of the human brain, without volume pre selection offers considerable advantage over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectral curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtain full volumetric brain coverage and data acquisition at short spin-echo times (TE<30 ms) for the detection of metabolites. (author)

  10. Pion Production from Proton Synchrotron Radiation under Strong Magnetic Field in Relativistic Quantum Approach

    Directory of Open Access Journals (Sweden)

    Maruyama Tomoyuki

    2016-01-01

    Full Text Available We study pion production from proton synchrotron radiation in the presence of strong magnetic fields by using the exact proton propagator in a strong magnetic field and explicitly including the anomalous magnetic moment. Results in this exact quantum-field approach do not agree with those obtained in the semi-classical approach. Furthermore, we also find that the anomalous magnetic moment of the proton greatly enhances the production rate about by two orders of magnitude, and that the polar angle of an emitted pion is the same as that of an initial proton.

  11. Some recoil corrections to the hydrogen hyperfine splitting

    International Nuclear Information System (INIS)

    Bodwin, G.T.; Yennie, D.R.

    1988-01-01

    We compute all of the recoil corrections to the ground-state hyperfine splitting in hydrogen, with the exception of the proton polarizability, that are required to achieve an accuracy of 1 ppm. Our approach includes a unified treatment of the corrections that would arise from a pointlike Dirac proton and the corrections that are due to the proton's non-QED structure. Our principal new results are a calculation of the relative order-α 2 (m/sub e//m/sub p/) contributions that arise from the proton's anomalous magnetic moment and a systematic treatment of the relative order-α(m/sub e//m/sub p/) contributions that arise from form-factor corrections. In the former calculation we introduce some new technical improvements and are able to evaluate all of the expressions analytically. In the latter calculation, which has been the subject of previous investigations by other authors, we express the form-factor corrections in terms of two-dimensional integrals that are convenient for numerical evaluation and present numerical results for the commonly used dipole parametrization of the form factors. Because we use a parametrization of the form factors that differs slightly from the ones used in previous work, our numerical results are shifted from older ones by a small amount

  12. Fabrication of miniature magnetic magnet pole for validate simulation of magnetic cyclotron proton 13 MeV

    International Nuclear Information System (INIS)

    Subroto; Sukiya; Tony R

    2013-01-01

    A fabrication of miniature magnetic pole field has been made to validate the simulation system 13 MeV magnet of proton cyclotron using mild steel material. This electromagnet of magnetic pole at the end of the magnetic pole is divided into 8 parts of the valley and the hill interval to produce different magnetic field. Pole magnetic field fabrication is meet to match the design of the system simulation results 13 MeV cyclotron magnet. This requires strong cyclotron magnetic field average at 1.275 T magnetic field strength of each piece was different. So that the ion beam passing through a magnetic field. Will be focused before mashing target. The surface of magnetic pole is circular with a diameter of 100 mm and 32 mm pole spacing. Miniature of electrical pole diameter is only one-tenth the diameter of 960 mm designed this requires current 10 A with voltage 30 V to produce field strength of 0.3 T. To measure the magnetic field strength tesla meter is used and to measure the relationship curve in pole position with a magnetic field strength magnets cylinder directions X and Y the used mini lathe. Field strength measurement results with a straight, oblique and circular position show nearly equal to curve simulation results using a 3D module TOSCA opera program. (author)

  13. Proton nuclear magnetic resonance spectroscopy of plasma lipoproteins in malignancy

    International Nuclear Information System (INIS)

    Nabholtz, J.M.; Rossignol, A.; Farnier, M.; Gambert, P.; Tremeaux, J.C.; Friedman, S.; Guerrin, J.

    1988-01-01

    A recent study described a method of detecting malignant tumors by water-supressed proton nuclear magnetic resonance (1 H NMR) study of plasma. We performed a similar study of the W 1/2, a mean of the full width at half height of the resonances of the methyl and methylene groups of the lipids of plasma lipoproteins which is inversely related to the spin-spin apparent relaxation time (T 2 * ). W 1/2 values were measured at a fixed baseline width of 310 Hz. The study was prospective and blinded and comprised 182 subjects consisting of 40 controls, 68 patients with untreated malignancies, 45 with malignant tumors undergoing therapy and 29 benign tumor patients. No differences were seen between any groups that could serve as a basis for a useful clinical test. The major difficulty in the determination of W 1/2 was due to interference of metabolite protons (particularly lactate) within the lipoprotein resonance signal. Triglyceride level was seen to correlate inversely with W 1/2 within malignant patient groups. These discrepant results may be related to differing triglyceride-rich very low density lipoprotein (VLDL) levels in the ;atient populations of each study. We conclude that the water-suppressed 1H NMR of plasma lipoproteins is not a valid measurement for assessing malignancy. (orig.)

  14. Pion Production from Proton Synchrotron Radiation under Strong Magnetic Field in a Relativistic Quantum Approach

    Directory of Open Access Journals (Sweden)

    Maruyama Tomoyuki

    2016-01-01

    Full Text Available We study pion production from proton synchrotron radiation in the presence of strong magnetic fields by using the exact proton propagator in a strong magnetic field and explicitly including the anomalous magnetic moment. Results in this exact quantum approach do not agree with those obtained in the semi-classical approach. Then, we find that the anomalous magnetic moment of the proton greatly enhances the production rate by about two orders magnitude, and that the decay width satisfies a robust scaling law.

  15. Electromagnetic radiation of protons in edge fields of synchrotron dipole magnets

    International Nuclear Information System (INIS)

    Smolyakov, N.V.

    1986-01-01

    Effect of the edge shape of magnetic field of a dipole on the short-wave part of electromagnetic radiation spectrum of a proton beam is investigated. In some cases short-wave photons are shown to be shaped in the ranges of largest edge curvature of the magnetic field. Universality of edge radiation spectrum is proved. Spectral characteristics of proton edge radiation in a superconducting magnetic dipole of the storage-accelerator complex are obtained

  16. Regional-Scale Surface Magnetic Fields and Proton Fluxes to Mercury's Surface from Proton-Reflection Magnetometry

    Science.gov (United States)

    Winslow, R. M.; Johnson, C. L.; Anderson, B. J.; Gershman, D. J.; Raines, J. M.; Lillis, R. J.; Korth, H.; Slavin, J. A.; Solomon, S. C.; Zurbuchen, T.

    2014-12-01

    The application of a recently developed proton-reflection magnetometry technique to MESSENGER spacecraft observations at Mercury has yielded two significant findings. First, loss-cone observations directly confirm particle precipitation to Mercury's surface and indicate that solar wind plasma persistently bombards the planet not only in the magnetic cusp regions but over a large fraction of the southern hemisphere. Second, the inferred surface field strengths independently confirm the north-south asymmetry in Mercury's global magnetic field structure first documented from observations of magnetic equator crossings. Here we extend this work with 1.5 additional years of observations (i.e., to 2.5 years in all) to further probe Mercury's surface magnetic field and better resolve proton flux precipitation to the planet's surface. We map regions where proton loss cones are observed; these maps indicate regions where protons precipitate directly onto the surface. The augmentation of our data set over that used in our original study allows us to examine the proton loss cones in cells of dimension 10° latitude by 20° longitude in Mercury body-fixed coordinates. We observe a transition from double-sided to single-sided loss cones in the pitch-angle distributions; this transition marks the boundary between open and closed field lines. At the surface this boundary lies between 60° and 70°N. Our observations allow the estimation of surface magnetic field strengths in the northern cusp region and the calculation of incident proton fluxes to both hemispheres. In the northern cusp, our regional-scale observations are consistent with an offset dipole field and a dipole moment of 190 nT RM3, where RM is Mercury's radius, implying that any regional-scale variations in surface magnetic field strengths are either weak relative to the dipole field or occur at length scales smaller than the resolution of our observations (~300 km). From the global proton flux map (north of 40° S

  17. Multivoxel proton magnetic resonance spectroscopy in heat stroke

    International Nuclear Information System (INIS)

    Li, J.; Zhang, X.Y.; Wang, B.; Zou, Z.M.; Li, H.F.; Wang, P.Y.; Xia, J.K.

    2015-01-01

    Aim: To assess the role of proton MR spectroscopy (MRS) in the detection of changes in metabolite levels of the cerebellum after heat stroke (HS). Materials and methods: The study group consisted of eight patients after HS, with a Glasgow Coma Scale (GCS) score of 3–9. The MR studies were performed with a 1.5 T system. MR spectra were recorded from a normal-appearing cerebellum region. Spectra from patients were compared with a control group including seven age-matched healthy volunteers recorded with the same techniques. Metabolites ratios including N-acetyl aspartate/creatine (NAA/Cr), N-acetyl aspartate/creatine2 (NAA/Cr2), choline/creatine (Cho/Cr), choline/creatine2 (Cho/Cr2), and N-acetyl aspartate/choline (NAA/Cho) were calculated and the differences between the two groups were evaluated using the Mann–Whitney U-test. Pearson correlation analysis was used to analyse the relationship between NAA/Cr ratios and GCS scores for eight patients after HS. Results: In the cerebellum of the patients after HS, NAA/Cr ratios were found to be significantly decreased compared to normal controls (p = 0.004) and Cho/Cr ratios were found to be decreased compared to normal controls (p = 0.032). Significant positive correlation was found between NAA/Cr ratios and GCS scores for eight patients after HS (r = 0.748, p = 0.033). Conclusions: Metabolite abnormalities were seen in normal-appearing cerebellum structures in patients after HS. Proton MRS is a useful tool for evaluating major changes in metabolite levels of the cerebellum after HS and the severity of the disease can be effectively evaluated by NAA/Cr ratios. - Highlights: • Proton magnetic resonance spectroscopy offers important information in patients with heat stroke. • Significantly different NAA/Cr ratios were found between heat stroke and controls. • The severity of heat stroke can be effectively evaluated by NAA/Cr ratios

  18. S.C. correction coils and magnets for the HERA proton ring

    International Nuclear Information System (INIS)

    Daum, C.; Geerinck, J.; Schmueser, P.

    1986-05-01

    The quadrupole and sextupole correction coils of the HERA proton ring are mounted on the cold beam pipe inside the main dipole magnets. Superferric dipole magnets for orbit correction are located adjacent to the main quadrupole magnets in a common cryostat which also contains the beam monitor. The design, manufacture and performance of both types of correction elements are described. (orig.)

  19. Magnetic quadrupoles lens for hot spot proton imaging in inertial confinement fusion

    Energy Technology Data Exchange (ETDEWEB)

    Teng, J. [Science and Technology on Plasma Physics Laboratory, Laser Fusion Research Center, China Academy of Engineering Physics, Mianyang 621900 (China); Gu, Y.Q., E-mail: yqgu@caep.cn [Science and Technology on Plasma Physics Laboratory, Laser Fusion Research Center, China Academy of Engineering Physics, Mianyang 621900 (China); Center for Applied Physics and Technology, HEDPS, Peking University, Beijing 100871 (China); Chen, J.; Zhu, B.; Zhang, B.; Zhang, T.K.; Tan, F.; Hong, W.; Zhang, B.H. [Science and Technology on Plasma Physics Laboratory, Laser Fusion Research Center, China Academy of Engineering Physics, Mianyang 621900 (China); Wang, X.Q. [Academy of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026 (China)

    2016-08-01

    Imaging of DD-produced protons from an implosion hot spot region by miniature permanent magnetic quadrupole (PMQ) lens is proposed. Corresponding object-image relation is deduced and an adjust method for this imaging system is discussed. Ideal point-to-point imaging demands a monoenergetic proton source; nevertheless, we proved that the blur of image induced by proton energy spread is a second order effect therefore controllable. A proton imaging system based on miniature PMQ lens is designed for 2.8 MeV DD-protons and the adjust method in case of proton energy shift is proposed. The spatial resolution of this system is better than 10 μm when proton yield is above 10{sup 9} and the spectra width is within 10%.

  20. Proton nuclear magnetic resonance studies on brain edema

    International Nuclear Information System (INIS)

    Naruse, S.; Horikawa, Y.; Tanaka, C.; Hirakawa, K.; Nishikawa, H.; Yoshizaki, K.

    1982-01-01

    The water in normal and edematous brain tissues of rats was studied by the pulse nuclear magnetic resonance (NMR) technique, measuring the longitudinal relaxation time (T1) and the transverse relaxation time (T2). In the normal brain, T1 and T2 were single components, both shorter than in pure water. Prolongation and separation of T2 into two components, one fast and one slow, were the characteristic findings in brain edema induced by both cold injury and triethyl tin (TET), although some differences between the two types of edema existed in the content of the lesion and in the degree of changes in T1 and T2 values. Quantitative analysis of T1 and T2 values in their time course relating to water content demonstrated that prolongation of T1 referred to the volume of increased water in tissues examined, and that two phases of T2 reflected the distribution and the content of the edema fluid. From the analysis of the slow component of T2 versus water content during edema formation, it was demonstrated that the increase in edema fluid was steady, and its content was constant during formation of TET-induced edema. On the contrary, during the formation of cold-injury edema, water-rich edema fluid increased during the initial few hours, and protein-rich edema fluid increased thereafter. It was concluded that proton NMR relaxation time measurements may provide new understanding in the field of brain edema research

  1. Proton magnetic resonance spectroscopy in disturbances of cortical development

    International Nuclear Information System (INIS)

    Kaminaga, T.; Kobayashi, M.; Abe, T.

    2001-01-01

    Proton magnetic resonance spectroscopy( 1 H-MRS) can be used for looking at cerebral metabolites in vivo. However, measurement of concentrations of cerebral metabolites in patients with disturbances of cerebral development have not been successful. Our purpose was to measure the concentrations of cerebral metabolites in such patients. We carried out quantitative 1 H-MRS in eight patients with cortical dysplasia, four with lissencephaly and three with heterotopic grey matter and six age-matched normal controls. Regions of interest for 1 H-MRS were set over the affected cortex in the patients and the occipital cortex in controls. The calculated concentration of N-acetylaspartate (NAA) was significantly lower in the affected cortex in patients with cortical dysplasia (P < 0.05), lissencephaly (P < 0.01), and heterotopia (P < 0.05) than in controls, idnicating a decreased number and/or immaturity or dysfunction of neurones in the affected cortex. The concentration of choline (Cho) was significantly lower in patients with lissencephaly (P < 0.01) than in controls, indicating glial proliferation and/or membrane abnormality. (orig.)

  2. Proton magnetic resonance spectroscopy in ecstasy (MDMA) users.

    Science.gov (United States)

    Daumann, Jörg; Fischermann, Thomas; Pilatus, Ulrich; Thron, Armin; Moeller-Hartmann, Walter; Gouzoulis-Mayfrank, Euphrosyne

    2004-05-20

    The popular recreational drug 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) has well-recognized neurotoxic effects upon central serotonergic systems in animal studies. In humans, the use of MDMA has been linked to cognitive problems, particularly to deficits in long-term memory and learning. Recent studies with proton magnetic resonance spectroscopy (1H MRS) have reported relatively low levels of the neuronal marker N-acetylaspartate (NAA) in MDMA users, however, these results have been ambiguous. Moreover, the only available 1H MRS study of the hippocampus reported normal findings in a small sample of five MDMA users. In the present study, we compared 13 polyvalent ecstasy users with 13 matched controls. We found no differences between the NAA/creatine/phosphocreatine (Cr) ratios of users and controls in neocortical regions, and only a tendency towards lower NAA/Cr ratios in the left hippocampus of MDMA users. Thus, compared with cognitive deficits, 1H MRS appears to be a less sensitive marker of potential neurotoxic damage in ecstasy users. Copyright 2004 Elsevier Ireland Ltd.

  3. Recoil transporter devices

    International Nuclear Information System (INIS)

    Madhavan, N.

    2005-01-01

    The study of sparsely produced nuclear reaction products in the direction of intense primary beam is a challenging task, the pursuit of which has given rise to the advent or several types of selective devices. These range from a simple parallel plate electrostatic deflector to state-of-the-art electromagnetic separators. There is no single device which can satisfy all the requirements of an ideal recoil transporter, simultaneously. An overview of such devices and their building blocks is presented, which may help in the proper choice of the device as per the experimental requirements. (author)

  4. Recoiling D-branes

    International Nuclear Information System (INIS)

    Nakamura, Shin

    2005-01-01

    We propose a new method to describe a recoiling D-brane that is elastically scattered by closed strings in the nonrelativistic region. We utilize the low-energy effective field theory on the worldvolume of the D-brane, and the velocity of the D-brane is described by the time derivative of the expectation values of the massless scalar fields on the worldvolume. The effects of the closed strings are represented by a source term for the massless fields in this method. The momentum conservation condition between the closed strings and the D-brane is derived up to the relative sign of the momentum of the D-brane

  5. Effects of proton irradiation on electronic structure of NdFeB permanent magnets

    Energy Technology Data Exchange (ETDEWEB)

    Yang, L. [School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001 (China); Zhen, L. [School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001 (China)], E-mail: lzhen@hit.edu.cn; Xu, C.Y.; Sun, X.Y.; Shao, W.Z. [School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001 (China)

    2009-09-15

    Effects of proton irradiation on electronic structure and atomic local structure of N35EH-type NdFeB permanent magnet were investigated by soft X-ray absorption spectrometry and Moessbauer spectrometry. The local coordination environment of Fe atoms changes after proton irradiation, and the average hyperfine field H{sub in} of the magnets decreases from 288.4 to 286.9 kOe. The effects of irradiation on Fe atoms local environment at different lattice sites are different. The near edge structure of Fe L{sub 3} edge is changed, indicating the density of unoccupied state of Fe 3d electrons increases after proton irradiation.

  6. Proton nuclear magnetic resonance in paramagnetic CoCl2.6H2O

    International Nuclear Information System (INIS)

    Oravcova, J.; Murin, J.; Rakos, M.; Olcak, D.

    1978-01-01

    Nuclear magnetic resonance (NMR) is studied of protons of the crystal water of paramagnetic CoCl 2 .6H 2 O. The measurements were carried out on powdered samples at room temperature, for values of the external magnetic field ranging from 0.3 to 1.0 T. The NMR signals of protons of the crystal water exhibit asymmetric shape which changes with the applied external magnetic field. We found that the second moment of the resonance line shows a linear dependence on the square of the induction of the externally applied magnetic field. The cause of the asymmetry of the NMR line of protons of the crystal water and the dependence of the second moment of the resonance line on the induction of external magnetic field are interpreted. (author)

  7. Magnetically scanned proton therapy beams: rationales and techniques

    International Nuclear Information System (INIS)

    Jones, D.T.L.; Schreuder, A.N.

    2000-01-01

    Perhaps the most important advantages of beam scanning systems for proton therapy in comparison with conventional passive beam spreading systems are: (1) Intensity modulation and inverse planning are possible. (2) There is negligible reduction in the range of the beam. (3) Integral dose is reduced as dose conformation to the proximal edge of the lesion is possible. (4) In principle no field-specific modifying devices are required. (5) There is less activation of the surroundings. (6) Scanning systems axe almost infinitely flexible. The main disadvantages include: (1) Scanning systems are more complicated and therefore potentially less reliable and more dangerous. (2) The development of such systems is more demanding in terms of cost, time and manpower. (3) More stable beams are required. (4) Dose and beam position monitoring are more difficult. (5) The problems associated with patient and organ movement axe more severe. There are several techniques which can be used for scanning. For lateral beam spreading, circular scanning (wobbling) or linear scanning can be done. In the latter case the beam can be scanned continuously or in a discrete fashion (spot scanning). Another possibility is to undertake the fastest scan in one dimension (strip scanning) and translate the patient or the scanning magnet in the other dimension. Depth variation is achieved by interposing degraders in the beam (cyclotrons) or by changing the beam energy (synchrotrons). The aim of beam scanning is to deliver a predetermined dose at any point in the body. Special safety precautions must be taken because of the high instantaneous dose rates. The beam position and the dose delivered at each point must be accurately and redundantly determined. (author)

  8. Interpreting Recoil for Undergraduate Students

    Science.gov (United States)

    Elsayed, Tarek A.

    2012-01-01

    The phenomenon of recoil is usually explained to students in the context of Newton's third law. Typically, when a projectile is fired, the recoil of the launch mechanism is interpreted as a reaction to the ejection of the smaller projectile. The same phenomenon is also interpreted in the context of the conservation of linear momentum, which is…

  9. Proton ring trapping in a gated magnetic mirror

    International Nuclear Information System (INIS)

    Pedrow, P.D.; Greenly, J.B.; Hammer, D.A.; Sudan, R.N.

    1985-01-01

    An axis-encircling proton ring has been trapped for times (roughly-equal4 μs) much longer than the ion cyclotron period (roughly-equal80 ns). The rings, with mean radius 10 cm and with particle energies 15 protons during the first pass and 2 x 10 13 protons during the eighth and final pass. With a central solenoidal field of 0.8 T, the peak diamagnetism and azimuthal current density of the injected ring were typically 10 mT (100 G) and 10 A/cm 2 , respectively

  10. Proton GE/GM from beam-target asymmetry

    International Nuclear Information System (INIS)

    Mark Jones; Aram Aghalaryan; Abdellah Ahmidouch; Razmik Asaturyan; Frederic Bloch; Werner Boeglin; Peter Bosted; Cedric Carasco; Roger Carlini; Jinseok Cha; Jian-Ping Chen; Michael Christy; Leon Cole; Luminita Coman; Donald Crabb; Samuel Danagoulian; Donal Day; James Dunne; Mostafa Elaasar; Rolf Ent; Howard Fenker; Emil Frlez; David Gaskell; Liping Gan; Javier Gomez; Bitao Hu; Juerg Jourdan; Christopher Keith; Cynthia Keppel; Mahbubul Khandaker; Andreas Klein; Laird Kramer; Yongguang Liang; Jechiel Lichtenstadt; Richard Lindgren; David Mack; Paul McKee; Dustin McNulty; David Meekins; Hamlet Mkrtchyan; Rakhsha Nasseripour; Maria-Ioana Niculescu; Kristoff Normand; Blaine Norum; Dinko Pocanic; Yelena Prok; Brian Raue; Joerg Reinhold; Julie Roche; Daniela Rohe; Oscar Rondon-Aramayo; Nikolai Savvinov; Bradley Sawatzky; Mikell Seely; Ingo Sick; Karl Slifer; C. Smith; Gregory Smith; S. Stepanyan; Liguang Tang; Shigeyuki Tajima; Giuseppe Testa; William Vulcan; Kebin Wang; Glen Warren; Frank Wesselmann; Stephen Wood; Chen Yan; Lulin Yuan; Junho Yun; Markus Zeier; Hong Guo Zhu

    2006-01-01

    The ratio of the proton's electric to magnetic form factor, G E /G M , can be extracted in elastic electron-proton scattering by measuring either cross sections, beam-target asymmetry or recoil polarization. Separate determinations of G E /G M by cross sections and recoil polarization observables disagree for Q 2 > 1 (GeV/c) 2 . Measurement by a third technique might uncover an unknown systematic error in either of the previous measurements. The beam-target asymmetry has been measured for elastic electron-proton scattering at Q 2 = 1.51 (GeV/c) 2 for target spin orientation aligned perpendicular to the beam momentum direction. This is the largest Q 2 at which G E /G M has been determined by a beam-target asymmetry experiment. The result, μG E /G M = 0.884 +/- 0.027 +/- 0.029, is compared to previous world data

  11. High energy proton induced radiation damage of rare earth permanent magnet quadrupoles

    Science.gov (United States)

    Schanz, M.; Endres, M.; Löwe, K.; Lienig, T.; Deppert, O.; Lang, P. M.; Varentsov, D.; Hoffmann, D. H. H.; Gutfleisch, O.

    2017-12-01

    Permanent magnet quadrupoles (PMQs) are an alternative to common electromagnetic quadrupoles especially for fixed rigidity beam transport scenarios at particle accelerators. Using those magnets for experimental setups can result in certain scenarios, in which a PMQ itself may be exposed to a large amount of primary and secondary particles with a broad energy spectrum, interacting with the magnetic material and affecting its magnetic properties. One specific scenario is proton microscopy, where a proton beam traverses an object and a collimator in which a part of the beam is scattered and deflected into PMQs used as part of a diagnostic system. During the commissioning of the PRIOR (Proton Microscope for Facility for Antiproton and Ion Research) high energy proton microscope facility prototype at Gesellschaft für Schwerionenforschung in 2014, a significant reduction of the image quality was observed which was partially attributed to the demagnetization of the used PMQ lenses and the corresponding decrease of the field quality. In order to study this phenomenon, Monte Carlo simulations were carried out and spare units manufactured from the same magnetic material—single wedges and a fully assembled PMQ module—were deliberately irradiated by a 3.6 GeV intense proton beam. The performed investigations have shown that in proton radiography applications the above described scattering may result in a high irradiation dose in the PMQ magnets. This did not only decrease the overall magnetic strength of the PMQs but also caused a significant degradation of the field quality of an assembled PMQ module by increasing the parasitic multipole field harmonics which effectively makes PMQs impractical for proton radiography applications or similar scenarios.

  12. Proton magnetic resonance spectroscopy (1H-MRS) for the evaluation of treatment of brain tumours

    International Nuclear Information System (INIS)

    Houkin, K.; Kamada, K.; Sawamura, Y.; Iwasaki, Y.; Abe, H.; Kashiwaba, T.

    1995-01-01

    We investigated metabolic changes in brain tumours following treatment, using proton magnetic resonance spectroscopy. In meningiomas, effective therapeutic embolisation led to an acute increase in lactate. In radiosensitive tumours such as malignant lymphoma, a decrease in lactate and in increase in N-acetyl-aspartate occurred after radiotherapy, which preceded changes observed on magnetic resonance imaging. On the other hand, no significant changes in spectral patterns were observed in malignant gliomas resistant to therapy. Tissue characterisation of brain tumours by spectral patterns on proton magnetic resonance spectroscopy remains controversial. However, we have shown it to be sensitive to metabolic changes following treatment, which may reflect the efficacy of the therapy. (orig.)

  13. Enhancing the sensitivity of recoil-beta tagging

    International Nuclear Information System (INIS)

    Henderson, J; Jenkins, D G; Davies, P J; Henry, T W; Joshi, P; Nichols, A J; Ruotsalainen, P; Scholey, C; Auranen, K; Grahn, T; Greenlees, P T; Herzáň, A; Jakobsson, U; Julin, R; Juutinen, S; Konki, J; Leino, M; Pakarinen, J; Lotay, G; Obertelli, A

    2013-01-01

    Tagging with β-particles at the focal plane of a recoil separator has been shown to be an effective technique for the study of exotic proton-rich nuclei. This article describes three new pieces of apparatus used to greatly improve the sensitivity of the recoil-beta tagging technique. These include a highly-pixelated double-sided silicon strip detector, a plastic phoswich detector for discriminating high-energy β-particles, and a charged-particle veto box. The performance of these new detectors is described and characterised, and the resulting improvements are discussed.

  14. Characterization of human breast disease using phosphorus magnetic resonance spectroscopy and proton magnetic resonance imaging

    International Nuclear Information System (INIS)

    Merchant, T.E.

    1992-01-01

    This thesis provides the fundamental characterization and differentiation of breast tissues using in vivo and ex vivo MR techniques in the hope that these techniques and experimental findings will be used on a larger scale and in a predictive manner in order to improve the specificity of diagnosis and treatment of breast cancer. In this dissertation, clinical studies were performed using proton magnetic resonance imaging and phosphorus magnetic resonance spectro-scopy ( 31 P MRS) to characterize and differentiate malignant breast tumors, benign breast tumors and normal breast tissues in vivo. These studies were carried out following the methodical characterization of chemical extracts of malignant breast tumor, benign breast tumor and normal breast parenchymal surgical tissue specimens using high resolution 31 P MRS. Alterations in breast tissue metabolism, as a result of pathological processes, were postulated to be responsible for measurable differences between malignant breast tumors, benign breast tumors and normal breast tissues using magnetic resonance techniques. (author). 365 refs.; 37 figs.; 25 tabs

  15. Design of the proposed 250 MeV superconducting cyclotron magnet for proton therapy

    International Nuclear Information System (INIS)

    Dey, M.K.; Ahmed, M.; Murali, S.; Duttagupta, A.; Chaudhuri, J.; Mallik, C.; Bhandari, R.K.

    2006-01-01

    Here we describe the design calculations for the superconducting magnet of a 250 MeV proton cyclotron to be used for therapeutic purpose. Hard-edge approximation method has been adopted for finding the poletip geometry to meet the basic focusing requirements of the beam. Then the uniform-magnetization method has been applied to calculate the 3D magnetic field distribution due to saturated iron poletips, to verify the beam dynamical issues. (author)

  16. A recoil detector of Koala experiment at HESR

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Huagen [Forschungszentrum Juelich (Germany)

    2015-07-01

    The concept of the luminosity detector for the PANDA experiment is based on measuring antiproton-proton elastic scattering in the Coulomb-nuclear interference region by 4 planes of HV-MAPS tracking detectors. The absolute precision is limited by the lack of existing data of the physics quantities σ{sub tot}, ρ and b describing the differential cross section as a function of squared 4-momentum transfer t in the relevant beam momentum region. Therefore, the so-called Koala experiment has been proposed to measure antiproton-proton elastic scattering. The goal of Koala experiment is to measure a wide range of t-distribution to determine the parameters σ{sub tot}, ρ and b. The idea is to measure the scattered beam antiprotons at forward angles by tracking detectors and the recoil target protons near 90 {sup circle} by energy detectors. In order to validate this method a recoil detector has been designed and built. Commissioning of the recoil detector by measuring proton-proton elastic scattering has been performed at COSY. Preliminary results of the commissioning are presented.

  17. D0-brane recoil revisited

    Energy Technology Data Exchange (ETDEWEB)

    Craps, Ben [Theoretische Natuurkunde, Vrije Universiteit Brussel and The International Solvay Institutes, Pleinlaan 2, B-1050 Brussels (Belgium); Evnin, Oleg [California Institute of Technology 452-48, Pasadena, CA 91125 (United States); Nakamura, Shin [Physics Department, Hanyang University, Seoul, 133-791 (Korea, Republic of)

    2006-12-15

    One-loop string scattering amplitudes computed using the standard D0-brane conformal field theory (CFT) suffer from infrared divergences associated with recoil. A systematic framework to take recoil into account is the worldline formalism, where fixed boundary conditions are replaced by dynamical D0-brane worldlines. We show that, in the worldline formalism, the divergences that plague the CFT are automatically cancelled in a non-trivial way. The amplitudes derived in the worldline formalism can be reproduced by deforming the CFT with a specific 'recoil operator', which is bilocal and different from the ones previously suggested in the literature.

  18. Proton radiography of magnetic field in laser produced plasma

    International Nuclear Information System (INIS)

    Le Pape, S.; Patel, P.; Chen, S.; Town, R.; Mackinnon, A.

    2009-01-01

    Electromagnetic fields generated by the interaction with plasmas of long-pulse laser beams relevant to inertial confinement fusion have been measure. A proton beam generated by the interaction of an ultra intense laser with a thin metallic foil is used to probe the B-fields. The proton beam then generated is temporally short (of the order of a ps), highly laminar and hence equivalent to a virtual point which makes it an ideal source for radiography. We have investigated, using face-on radiography, B fields at intensity around 10 14 W/cm 2 due to the non co-linearity of temperature and density gradients. (authors)

  19. Calculation of fusion gain in fast ignition with magnetic target by relativistic electrons and protons

    International Nuclear Information System (INIS)

    Parvazian, A.; Javani, A.

    2010-01-01

    Fast ignition is a new method for inertial confinement fusion in which the compression and ignition steps are separated. In the first stage, fuel is compressed by laser or ion beams. In the second phase, relativistic electrons are generated by pettawat laser in the fuel. Also, in the second phase 5-35 MeV protons can be generated in the fuel. Electrons or protons can penetrate in to the ultra-dense fuel and deposit their energy in the fuel. More recently, cylindrical rather than spherical fuel chambers with magnetic control in the plasma domain have been also considered. This is called magnetized target fusion. Magnetic field has effects on relativistic electrons energy deposition rate in fuel. In this work, fast ignition method in cylindrical fuel chambers is investigated and transportation of the relativistic electrons and protons is calculated using MCNPX and FLUKA codes with 0.25 and 0.5 tesla magnetic field in single and dual hot spot. Furthermore, the transfer rate of relativistic electrons and high energy protons to the fuel and fusion gain are calculated. The results show that the presence of external magnetic field guarantees higher fusion gain, and relativistic electrons are much more appropriate objects for ignition. Magnetized target fusion in dual hot spot can be considered as an appropriate substitution for the current inertial confinement fusion techniques.

  20. WE-D-17A-04: Magnetically Focused Proton Irradiation of Small Volume Targets

    Energy Technology Data Exchange (ETDEWEB)

    McAuley, G; Slater, J [Loma Linda University, Loma Linda, CA (United States); Wroe, A [Loma Linda University Medical Center, Loma Linda, CA (United States)

    2014-06-15

    Purpose: To explore the advantages of magnetic focusing for small volume proton irradiations and the potential clinical benefits for radiosurgery targets. The primary goal is to create narrow elongated proton beams of elliptical cross section with superior dose delivery characteristics compared to current delivery modalities (eg, collimated beams). In addition, more general beam shapes are also under investigation. Methods: Two prototype magnets consisting of 24 segments of samarium-cobalt (Sm2Co17) permanent magnetic material adhered into hollow cylinders were manufactured for testing. A single focusing magnet was placed on a positioning track on our Gantry 1 treatment table and 15 mm diameter proton beams with energies and modulation relevant to clinical radiosurgery applications (127 to 186 MeV, and 0 to 30 mm modulation) were delivered to a terminal water tank. Beam dose distributions were measured using a PTW diode detector and Gafchromic EBT2 film. Longitudinal and transverse dose profiles were analyzed and compared to data from Monte Carlo simulations analogous to the experimental setup. Results: The narrow elongated focused beam spots showed high elliptical symmetry indicating high magnet quality. In addition, when compared to unfocused beams, peak-to-entrance depth dose ratios were 11 to 14% larger (depending on presence or extent of modulation), and minor axis penumbras were 11 to 20% smaller (again depending on modulation) for focused beams. These results suggest that the use of rare earth magnet assemblies is practical and could improve dose-sparing of normal tissue and organs at risk while delivering enhanced dose to small proton radiosurgery targets. Conclusion: Quadrapole rare earth magnetic assemblies are a promising and inexpensive method to counteract particle out scatter that tends to degrade the peak to entrance performance of small field proton beams. Knowledge gained from current experiments will inform the design of a prototype treatment

  1. Account of magnetic field effects of polarized proton target on charged particle trajectories in experiments with magnetic spectrometers

    International Nuclear Information System (INIS)

    Telegin, Yu.N.; Ranyuk, Yu.N.; Karnaukhov, I.M.; Lukhanin, A.A.; Sporov, E.A.

    1980-01-01

    Some effects of the influence of magnetic field of a polarized proton target (PPT) on trajectories of secondary particles in experiments using magnetic spectrometers are considered. It is shown that these effects can be eliminated by the target shift relatively to the spectrometer rotation axis and variation of the spectrometer installation angle. Numerical calculations of the correction values were performed for emitted particle momenta of 100-800 MeB/s and working intensity of the H 0 magnetic field H 0 =27 kG. The influence of the PPT magnetic field on the functions of angular and energy resolution in the γp→π + n experiment is investigated. The results obtained can be used in experiments with a polarized proton target

  2. Cage effect in recoil studies

    International Nuclear Information System (INIS)

    Berei, K.

    1983-09-01

    The role of cage effect is one of the most discussed questions of hot atom chemistry in condensed organic systems. So far no direct evidence is available for assessing the exact contribution of thermal recombinations occurring in the liquid cage to the stabilization processes of recoil atoms. However, some conclusions can be drawn from experimental observations concerning the influence on product yield of hot atom recoil spectra, the effects of density, phase and long range order of the medium as well as from comparisons with systems providing cage walls of different chemical reactivities towards the recoil atom. Recent developments in this field are reviewed based primarily on the investigations of recoil halogen reactions in aliphatic and aromatic hydrocarbons and their haloderivatives. (author)

  3. Calculation of fusion gain in fast ignition with magnetic target by relativistic electrons and protons

    Directory of Open Access Journals (Sweden)

    A Parvazian

    2010-12-01

    Full Text Available Fast ignition is a new method for inertial confinement fusion (ICF in which the compression and ignition steps are separated. In the first stage, fuel is compressed by laser or ion beams. In the second phase, relativistic electrons are generated by pettawat laser in the fuel. Also, in the second phase 5-35 MeV protons can be generated in the fuel. Electrons or protons can penetrate in to the ultra-dense fuel and deposit their energy in the fuel . More recently, cylindrical rather than spherical fuel chambers with magnetic control in the plasma domain have been also considered. This is called magnetized target fusion (MTF. Magnetic field has effects on relativistic electrons energy deposition rate in fuel. In this work, fast ignition method in cylindrical fuel chambers is investigated and transportation of the relativistic electrons and protons is calculated using MCNPX and FLUKA codes with 0. 25 and 0. 5 tesla magnetic field in single and dual hot spot. Furthermore, the transfer rate of relativistic electrons and high energy protons to the fuel and fusion gain are calculated. The results show that the presence of external magnetic field guarantees higher fusion gain, and relativistic electrons are much more appropriate objects for ignition. MTF in dual hot spot can be considered as an appropriate substitution for the current ICF techniques.

  4. Magnetic Resonance Studies of Proton Loss from Carotenoid Radical Cations

    Energy Technology Data Exchange (ETDEWEB)

    Kispert, Lowell D [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Focsan, A Ligia [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Konovalova, Tatyana A [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Lawrence, Jesse [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bowman, Michael K [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Dixon, David A [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Molnar, Peter [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Deli, Jozsef [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2007-06-11

    Carotenoids, intrinsic components of reaction centers and pigment-protein complexes in photosynthetic membranes, play a photoprotective role and serve as a secondary electron donor. Before optimum use of carotenoids can be made in artificial photosynthetic systems, their robust nature in living materials requires extensive characterization of their electron transfer, radical trapping ability, stability, structure in and on various hosts, and photochemical behavior. Pulsed ENDOR and 2D-HYSCORE studies combined with DFT calculations reveal that photo-oxidation of natural zeaxanthin (I) and violaxanthin (II) on silica-alumina produces not only the carotenoid radical cations (Car•+) but also neutral radicals (#Car•) by proton loss from the methyl groups at positions 5 or 5', and possibly 9 or 9' and 13 or 13'. Notably, the proton loss favored in I at the 5 position by DFT calculations, is unfavorable in II due to the epoxide at the 5, 6 position. DFT calculations predict the isotropic methyl proton couplings of 8-10 MHz for Car•+ which agree with the ENDOR for carotenoid α-conjugated radical cations. Large α-proton hyperfine coupling constants (>10 MHz) determined from HYSCORE are assigned from the DFT calculations to neutral carotenoid radicals. Proton loss upon photolysis was also examined as a function of carotenoid polarity [Lycopene (III) versus 8'-apo-β-caroten-8'-al (IV)]; hydrogen bonding [Lutein (V) versus III]; host [silica-alumina versus MCM-41 molecular sieve]; and substituted metal in MCM-41. Loss of H+ from the 5(5'), 9(9') or 13(13') methyl positions has importance in photoprotection. Photoprotection involves nonphotochemical quenching (NPQ) in which 1Ch1* decays via energy transfer to the carotenoid which returns to the ground state by thermal dissipation; or via electron transfer to form a charge transfer state (I •+…Chl•-), lower in energy than 1Chl*. Formation of I •+ results in bond

  5. Magnetic Resonance Studies of Proton Loss from Carotenoid Radical Cations

    International Nuclear Information System (INIS)

    Kispert, Lowell D.; Focsan, A. Ligia; Konovalova, Tatyana A.; Lawrence, Jesse; Bowman, Michael K.; Dixon, David A.; Molnar, Peter; Deli, Jozsef

    2007-01-01

    Carotenoids, intrinsic components of reaction centers and pigment-protein complexes in photosynthetic membranes, play a photoprotective role and serve as a secondary electron donor. Before optimum use of carotenoids can be made in artificial photosynthetic systems, their robust nature in living materials requires extensive characterization of their electron transfer, radical trapping ability, stability, structure in and on various hosts, and photochemical behavior. Pulsed ENDOR and 2D-HYSCORE studies combined with DFT calculations reveal that photo-oxidation of natural zeaxanthin (I) and violaxanthin (II) on silica-alumina produces not only the carotenoid radical cations (Car ·+ ) but also neutral radicals ((number s ign)Car · ) by proton loss from the methyl groups at positions 5 or 5(prime), and possibly 9 or 9(prime) and 13 or 13(prime). Notably, the proton loss favored in I at the 5 position by DFT calculations, is unfavorable in II due to the epoxide at the 5, 6 position. DFT calculations predict the isotropic methyl proton couplings of 8-10 MHz for Car # center d ot# + which agree with the ENDOR for carotenoid π-conjugated radical cations. Large α-proton hyperfine coupling constants (>10 MHz) determined from HYSCORE are assigned from the DFT calculations to neutral carotenoid radicals. Proton loss upon photolysis was also examined as a function of carotenoid polarity (Lycopene (III) versus 8(prime)-apo-β-caroten-8(prime)-al (IV)); hydrogen bonding (Lutein (V) versus III); host (silica-alumina versus MCM-41 molecular sieve); and substituted metal in MCM-41. Loss of H + from the 5(5(prime)), 9(9(prime)) or 13(13(prime)) methyl positions has importance in photoprotection. Photoprotection involves nonphotochemical quenching (NPQ) in which 1 Ch1* decays via energy transfer to the carotenoid which returns to the ground state by thermal dissipation; or via electron transfer to form a charge transfer state (I # center d ot# + ...Chl # center d ot# - ), lower in

  6. Neutron electric form factor via recoil polarimetry

    International Nuclear Information System (INIS)

    Richard Madey; Andrei Semenov; Simon Taylor; Aram Aghalaryan; Erick Crouse; Glen MacLachlan; Bradley Plaster; Shigeyuki Tajima; William Tireman; Chenyu Yan; Abdellah Ahmidouch; Brian Anderson; Razmik Asaturyan; O. Baker; Alan Baldwin; Herbert Breuer; Roger Carlini; Michael Christy; Steve Churchwell; Leon Cole; Samuel Danagoulian; Donal Day; Mostafa Elaasar; Rolf Ent; Manouchehr Farkhondeh; Howard Fenker; John Finn; Liping Gan; Kenneth Garrow; Paul Gueye; Calvin Howell; Bitao Hu; Mark Jones; James Kelly; Cynthia Keppel; Mahbubul Khandaker; Wooyoung Kim; Stanley Kowalski; Allison Lung; David Mack; D. Manley; Pete Markowitz; Joseph Mitchell; Hamlet Mkrtchyan; Allena Opper; Charles Perdrisat; Vina Punjabi; Brian Raue; Tilmann Reichelt; Joerg Reinhold; Julie Roche; Yoshinori Sato; Wonick Seo; Neven Simicevic; Gregory Smith; Samuel Stepanyan; Vardan Tadevosyan; Liguang Tang; Paul Ulmer; William Vulcan; John Watson; Steven Wells; Frank Wesselmann; Stephen Wood; Chen Yan; Seunghoon Yang; Lulin Yuan; Wei-Ming Zhang; Hong Guo Zhu; Xiaofeng Zhu

    2003-01-01

    The ratio of the electric to the magnetic form factor of the neutron, G En /G Mn , was measured via recoil polarimetry from the quasielastic d((pol-e),e(prime)(pol-n)p) reaction at three values of Q 2 [viz., 0.45, 1.15 and 1.47 (GeV/c) 2 ] in Hall C of the Thomas Jefferson National Accelerator Facility. Preliminary data indicate that G En follows the Galster parameterization up to Q 2 = 1.15 (GeV/c) 2 and appears to rise above the Galster parameterization at Q 2 = 1.47 (GeV/c) 2

  7. Proton compton scattering in the resonance region

    International Nuclear Information System (INIS)

    Ishii, Takanobu.

    1979-12-01

    Differential cross sections of the proton Compton scattering have been measured in the energy range between 400 and 1150 MeV at CMS angles of 130 0 , 100 0 and 70 0 . The recoil proton was detected with a magnetic spectrometer using multi-wire proportional chambers and wire spark chambers. In coincidence with the proton, the scattered photon was detected with a lead glass Cerenkov counter of the total absorption type with a lead plate converter, and horizontal and vertical scintillation counter hodoscopes. The background due to the neutral pion photoproduction, was subtracted by using the kinematic relations between the scattered photon and the recoil proton. Theoretical calculations based on an isobar model with two components, that is, the resonance plus background, were done, and the photon couplings of the second resonance region were determined firstly from the proton Compton data. The results are that the helicity 1/2 photon couplings of P 11 (1470) and S 11 (1535), and the helicity 3/2 photon coupling of D 13 (1520) are consistent with those determined from the single pion photoproduction data, but the helicity 1/2 photon coupling of D 13 (1520) has a somewhat larger value than that from the single pion photoproduction data. (author)

  8. Magnetic dipole moment of the doubly closed-shell plus one proton nucleus $^{49}$Sc

    CERN Multimedia

    Gaulard, C V; Walters, W; Nishimura, K; Muto, S; Bingham, C R

    It is proposed to measure the magnetic moment of $^{49}$Sc by the Nuclear Magnetic Resonance on Oriented Nuclei (NMR-ON) method using the NICOLE on-line nuclear orientation facility. $^{49}$Sc is the neutron rich, doubly closed-shell, nucleus $^{48}$Ca plus one proton. Results will be used to deduce the effective g-factors in the $^{48}$Ca region with reference to nuclear structure and meson exchange current effects.

  9. Preliminary analysis of proton magnetic resonance 1D spectra of cerebrospinal fluid and brain cancer extracts

    International Nuclear Information System (INIS)

    Toczylowska, B.; Jozwik, A.; Kierul, K.; Matysiak, Z.; Sidor, M.; Wojcik, J.

    1999-01-01

    In series of cerebrospinal fluid samples from 25 patients proton spectra of magnetic resonance were measured. The spectra were measured also for series of brain tumor tissue extracts received from another 25 patients. This paper presents an attempt to apply statistical methods of image recognition for spectra analysis of the two measured series

  10. Glutamatergic Effects of Divalproex in Adolescents with Mania: A Proton Magnetic Resonance Spectroscopy Study

    Science.gov (United States)

    Strawn, Jeffrey R.; Patel, Nick C.; Chu, Wen-Jang; Lee, Jing-Huei; Adler, Caleb M.; Kim, Mi Jung; Bryan, Holly S.; Alfieri, David C.; Welge, Jeffrey A.; Blom, Thomas J.; Nandagopal, Jayasree J.; Strakowski, Stephen M.; DelBello, Melissa P.

    2012-01-01

    Objectives: This study used proton magnetic resonance spectroscopy ([superscript 1]H MRS) to evaluate the in vivo effects of extended-release divalproex sodium on the glutamatergic system in adolescents with bipolar disorder, and to identify baseline neurochemical predictors of clinical remission. Method: Adolescents with bipolar disorder who were…

  11. Conceptual design of the superconducting magnet for the 250 MeV proton cyclotron.

    Science.gov (United States)

    Ren, Yong; Liu, Xiaogang; Gao, Xiang

    2016-01-01

    The superconducting cyclotron is of great importance to treat cancer parts of the body. To reduce the operation costs, a superconducting magnet system for the 250 MeV proton cyclotron was designed to confirm the feasibility of the superconducting cyclotron. The superconducting magnet system consists of a pair of split coils, the cryostat and a pair of binary high temperature superconductor current leads. The superconducting magnet can reach a central magnetic field of about 1.155 T at 160 A. The three GM cryocooler with cooling capacities of 1.5 W at 4.5 K and 35 W at 50 K and one GM cryocooler of 100 W at 50 K were adopted to cool the superconducting magnet system through the thermosiphon technology. The four GM cryocoolers were used to cool the superconducting magnet to realize zero evaporation of the liquid helium.

  12. Proton transport model in the ionosphere. 2. Influence of magnetic mirroring and collisions on the angular redistribution in a proton beam

    Directory of Open Access Journals (Sweden)

    M. Galand

    1998-10-01

    Full Text Available We investigate the influence of magnetic mirroring and elastic and inelastic scattering on the angular redistribution in a proton/hydrogen beam by using a transport code in comparison with observations. H-emission Doppler profiles viewed in the magnetic zenith exhibit a red-shifted component which is indicative of upward fluxes. In order to determine the origin of this red shift, we evaluate the influence of two angular redistribution sources which are included in our proton/hydrogen transport model. Even though it generates an upward flux, the redistribution due to magnetic mirroring effect is not sufficient to explain the red shift. On the other hand, the collisional angular scattering induces a much more significant red shift in the lower atmosphere. The red shift due to collisions is produced  by <1 -keV protons and is so small as to require an instrumental bandwidth <0.2 nm. This explains the absence of measured upward proton/hydrogen fluxes in the Proton I rocket data because no useable data concerning protons <1 keV are available. At the same time, our model agrees with measured ground-based H-emission Doppler profiles and suggests that previously reported red shift observations were due mostly to instrumental bandwidth broadening of the profile. Our results suggest that Doppler profile measurements with higher spectral resolution may enable us to quantify better the angular scattering in proton aurora.Key words. Auroral ionosphere · Particle precipitation

  13. Sunflower oil ozonation. Following of the reaction by proton Nuclear Magnetic Resonance

    International Nuclear Information System (INIS)

    Diaz Gomez, Maritza F.

    2005-01-01

    Previous studies have demonstrated that the technique of Proton Nuclear Magnetic Resonance can be used for the pursuit of the reaction between the ozone and the unsaturated fatty acids. It's carried out the sunflower oil ozonization to different applied dose of ozone and the index of peroxides and the concentration of aldehydes are determined. The main reaction products were identified by Proton Nuclear Magnetic Resonance Spectroscopy (NMR 1 H). The intensities of the signs were used to follow the advance of the reaction between the ozone and the sunflower oil. It is was carried out until obtaining an index of peroxides of 1 202 mmol-equiv/kg. The intensities of the signs of the olefinic protons diminish with a gradual increment in the dose of applied ozone, but without ending up disappearing completely. The ozonides of Criegee obtained to applied dose of ozone of 107,1 mg/g were approximately bigger 7,4 times that those obtained at the beginning from the reaction to applied dose of ozone of 15,3 mg/g. The aldehydes protons were observed as a sign of weak intensity in all the spectra. The signs belonging to the olenifics protons of the hydroperoxides in d = 5,55 ppm increases with the increment of the applied dose of ozone. You concludes that to higher applied dose of ozone, haggler is the advance of the ozonization reaction, what belongs together with a bigger formation of oxygenated compounds

  14. Chemical effects of fission recoils

    International Nuclear Information System (INIS)

    Meisels, G.G.; Freeman, J.P.; Gregory, J.P.; Richardson, W.C.; Sroka, G.J.

    1978-01-01

    The production of nitrogen from nitrous oxide at high density was employed to investigate the energy deposition efficiency of fission recoils produced from fission of U 235 in uranium-palladium foils clad with platinum. Nitrogen production varied linearly with fission recoil dose from 1.1 x 10 20 to 9.0 x 10 20 eV, and was independent of density between 12.5 and 127.5 g l -1 N 2 O. 16.2 +- 0.8% of the fission recoil energy was deposited external to the foil. Electron microprobe analysis showed some unevenness of new foil and polymer buildup on the surface after irradiation of ethylene-oxygen mixtures. Subsequent irradiation in the presence of nitrous oxide restored some of the original efficiency. This is ascribed to chemical oxidation of the polymer induced by reactive intermediates produced from nitrous oxide. (author)

  15. Proton magnetic resonance spectroscopy of tubercular breast abscess: report of a case.

    Science.gov (United States)

    Das, Chandan Jyoti; Medhi, Kunjahari

    2008-01-01

    In vivo proton magnetic resonance spectroscopy (H-MRS) is a functional imaging modality. When magnetic resonance imaging is coupled with H-MRS, it results in accurate metabolic characterization of various lesions. Proton magnetic resonance spectroscopy has an established role in evaluating malignant breast lesions, and the increasing number of published literature supports the role of H-MRS in patients with breast cancer. However, H-MRS can be of help in evaluating benign breast disease. We present a case of tubercular breast abscess, initial diagnosis of which was suggested based on characteristic lipid pick on H-MRS and was subsequently confirmed by fine needle aspiration biopsy of the breast lesion.

  16. Pulsed high field magnets. An efficient way of shaping laser accelerated proton beams for application

    Energy Technology Data Exchange (ETDEWEB)

    Kroll, Florian; Schramm, Ulrich [Helmholtz-Zentrum Dresden - Rossendorf, 01328 Dresden (Germany); Technische Universitaet Dresden, 01062 Dresden (Germany); Bagnoud, Vincent; Blazevic, Abel; Busold, Simon [GSI Helmholtzzentrum fuer Schwerionenforschung, 64291 Darmstadt (Germany); Helmholtz Institut Jena, 07734 Jena (Germany); Brabetz, Christian; Schumacher, Dennis [GSI Helmholtzzentrum fuer Schwerionenforschung, 64291 Darmstadt (Germany); Deppert, Oliver; Jahn, Diana; Roth, Markus [Technische Universitaet Darmstadt, 64289 Darmstadt (Germany); Karsch, Leonhard; Masood, Umar [OncoRay-National Center for Radiation Research in Oncology, TU Dresden, 01307 Dresden (Germany); Kraft, Stephan [Helmholtz-Zentrum Dresden - Rossendorf, 01328 Dresden (Germany)

    2015-07-01

    Compact laser-driven proton accelerators are a potential alternative to complex, expensive conventional accelerators, enabling unique beam properties, like ultra-high pulse dose. Nevertheless, they still require substantial development in reliable beam generation and transport. We present experimental studies on capture, shape and transport of laser and conventionally accelerated protons via pulsed high-field magnets. These magnets, common research tools in the fields of solid state physics, have been adapted to meet the demands of laser acceleration experiments.Our work distinctively shows that pulsed magnet technology makes laser acceleration more suitable for application and can facilitate compact and efficient accelerators, e.g. for material research as well as medical and biological purposes.

  17. Proton probe measurement of fast advection of magnetic fields by hot electrons

    International Nuclear Information System (INIS)

    Willingale, L; Thomas, A G R; Nilson, P M; Kaluza, M C; Dangor, A E; Evans, R G; Fernandes, P; Haines, M G; Kamperidis, C; Kingham, R J; Ridgers, C P; Sherlock, M; Wei, M S; Najmudin, Z; Krushelnick, K; Bandyopadhyay, S; Notley, M; Minardi, S; Rozmus, W; Tatarakis, M

    2011-01-01

    A laser generated proton beam was used to measure the megagauss strength self-generated magnetic fields from a nanosecond laser interaction with an aluminum target. At intensities of 10 15 W cm −2 , the significant hot electron production and strong heat fluxes result in non-local transport becoming important to describe the magnetic field dynamics. Two-dimensional implicit Vlasov–Fokker–Planck modeling shows that fast advection of the magnetic field from the focal region occurs via the Nernst effect at significantly higher velocities than the sound speed, v N /c s ≈ 10.

  18. Role of proton magnetic resonance spectroscopy in diagnosis of ...

    African Journals Online (AJOL)

    Mohammed Mahmoud Donia

    2012-01-23

    Jan 23, 2012 ... Subjects and methods: This study included seven pediatric patients ... ton magnetic resonance spectroscopy was done using either single or multi-voxel technique. ... with increased NAA/Cr ratio (2.32 ± 1.1). ... Table 1 Summary of the spectroscopic MRI findings in the seven patients included in the study.

  19. Motor-Generator powering the PS (Proton Synchrotron) main magnets

    CERN Multimedia

    1983-01-01

    This motor-generator,30 MW peak, 1500 r.p.m.,pulsed power supply for the PS main magnet replaced in 1968 the initial 3000 r.p.m. motor-generator-flywheel set which had served from the PS start-up in 1959 until end 1967. See also photo 8302337 and its abstract.

  20. Role of proton magnetic resonance spectroscopy in diagnosis of ...

    African Journals Online (AJOL)

    Background: Pilocytic astrocytomas are the second overall most common pediatric brain tumor. Magnetic resonance (MR) imaging is widely used in the diagnosis and follow up of pediatric patients with pilocytic astrocytomas because of its ability to provide anatomical detail. However conventional MR imaging does not ...

  1. Alternating-gradient canted cosine theta superconducting magnets for future compact proton gantries

    Directory of Open Access Journals (Sweden)

    Weishi Wan

    2015-10-01

    Full Text Available We present a design of superconducting magnets, optimized for application in a gantry for proton therapy. We have introduced a new magnet design concept, called an alternating-gradient canted cosine theta (AG-CCT concept, which is compatible with an achromatic layout. This layout allows a large momentum acceptance. The 15 cm radius of the bore aperture enables the application of pencil beam scanning in front of the SC-magnet. The optical and dynamic performance of a gantry based on these magnets has been analyzed using the fields derived (via Biot-Savart law from the actual windings of the AG-CCT combined with the full equations of motion. The results show that with appropriate higher order correction, a large 3D volume can be rapidly scanned with little beam shape distortion. A very big advantage is that all this can be done while keeping the AG-CCT fields fixed. This reduces the need for fast field ramping of the superconducting magnets between the successive beam energies used for the scanning in depth and it is important for medical application since this reduces the technical risk (e.g., a quench associated with fast field changes in superconducting magnets. For proton gantries the corresponding superconducting magnet system holds promise of dramatic reduction in weight. For heavier ion gantries there may furthermore be a significant reduction in size.

  2. Effectiveness of revascularization surgery evaluated by proton magnetic resonance spectroscopy and single photon emission computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Uno, Masaaki; Ueda, Shin; Hondo, Hideki; Matsumoto, Keizo; Harada, Masafumi [Tokushima Univ. (Japan). School of Medicine

    1996-08-01

    Proton magnetic resonance spectroscopy (MRS) and single photon emission computed tomography (SPECT) were used to evaluate chronic ischemic regions in 26 stroke patients before and 1, 3, and 6 months after revascularization surgery. The volume of interest for proton MRS was placed in an area including part of the frontal and temporal opercula, insular cortex, and basal ganglia. Twenty healthy volunteers served as controls for proton MRS. Patients were divided into three groups according to the preoperative proton MRS. Group A (n=12) had significantly lower N-acetylaspartate/choline (NAA/Cho) and N-acetylaspartate/creatine (NAA/Cr) ratios on the operative side compared to those on the contralateral side, and also lower than those in normal subjects. In seven patients in Group A, postoperative serial proton MRS demonstrated no recovery of these ratios on the operative side. However, proton MRS of the other five patients indicated gradual improvement in these ratios on the operative side at 3 to 6 months after surgery, and SPECT indicated an increase in cerebral blood flow on the operative side in four of these five patients. In Group B (n=9), proton MRS and SPECT showed no laterality before revascularization and no remarkable change during the postoperative course. In Group C (n=5), NAA/Cho or NAA/Cr decreased on the contralateral side preoperatively. Two patients showed fluctuating values of NAA/Cho or NAA/Cr during the postoperative period. Serial proton MRS and SPECT Studies may be useful for the evaluation of revascularization surgery on ischemic regions. The efficacy of revascularization surgery on the metabolism may appear gradually within 3-6 months. (author)

  3. Effects of High-Energy Proton-Beam Irradiation on the Magnetic Properties of ZnO Nanorods

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jun Kue; Kwon, Hyeok-Jung; Cho, Yong Sub [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    There are still many problem for the application due to its unstable magnetism state and too small magnetization values. Here we investigate magnetic properties of ZnO nanorods after high-energy proton-beam irradiation. Electron spin resonance (ESR) measurement on temperature was made to identify intrinsic or extrinsic defects as well as to observe magnetic ordering after irradiation. Understanding the effects of proton beam irradiation on magnetic behavior may help to shed light on the mechanism responsible for the magnetic ordering in this material. We have investigated proton-beam irradiation effects on the magnetic properties of ZnO nanorods. After irradiation a broad ESR line is observed, indicating emergence of ferromagnetic ordering up to room temperature. In M-H curve, stronger coercive field is observed after irradiation.

  4. SU-D-304-02: Magnetically Focused Proton Irradiation of Small Field Targets

    International Nuclear Information System (INIS)

    McAuley, GA; Slater, JM; Slater, JD; Wroe, AJ

    2015-01-01

    Purpose: To investigate the use of magnetic focusing for small field proton irradiations. It is hypothesized that magnetic focusing will provide significant dose distribution benefits over standard collimated beams for fields less than 10 mm diameter. Methods: Magnets consisting of 24 segments of radiation hard samarium-cobalt adhered into hollow cylinders were designed and manufactured. Two focusing magnets were placed on a positioning track on our Gantry 1 treatment table. Proton beams with energies of 127 and 157 MeV, 15 and 30 mm modulation, and 8 mm initial diameters were delivered to a water tank using single-stage scattering. Depth dose distributions were measured using a PTW PR60020 diode detector and transverse profiles were measured with Gafchromic EBT3 film. Monte Carlo simulations were also performed - both for comparison with experimental data and to further explore the potential of magnetic focusing in silica. For example, beam spot areas (based on the 90% dose contour) were matched at Bragg depth between simulated 100 MeV collimated beams and simulated beams focused by two 400 T/m gradient magnets. Results: Preliminary experimental results show 23% higher peak to entrance dose ratios and flatter spread out Bragg peak plateaus for 8 mm focused beams compared with uncollimated beams. Monte Carlo simulations showed 21% larger peak to entrance ratios and a ∼9 fold more efficient dose to target delivery compared to spot-sized matched collimated beams. Our latest results will be presented. Conclusion: Our results suggest that rare earth focusing magnet assemblies could reduce skin dose and beam number while delivering dose to nominally spherical radiosurgery targets over a much shorter time compared to unfocused beams. Immediate clinical applications include those associated with proton radiosurgery and functional radiosurgery of the brain and spine, however expanded treatment sites can be also envisaged

  5. SU-D-304-02: Magnetically Focused Proton Irradiation of Small Field Targets

    Energy Technology Data Exchange (ETDEWEB)

    McAuley, GA; Slater, JM [Loma Linda University, Loma Linda, CA (United States); Slater, JD; Wroe, AJ [Loma Linda University Medical Center, Loma Linda, CA (United States)

    2015-06-15

    Purpose: To investigate the use of magnetic focusing for small field proton irradiations. It is hypothesized that magnetic focusing will provide significant dose distribution benefits over standard collimated beams for fields less than 10 mm diameter. Methods: Magnets consisting of 24 segments of radiation hard samarium-cobalt adhered into hollow cylinders were designed and manufactured. Two focusing magnets were placed on a positioning track on our Gantry 1 treatment table. Proton beams with energies of 127 and 157 MeV, 15 and 30 mm modulation, and 8 mm initial diameters were delivered to a water tank using single-stage scattering. Depth dose distributions were measured using a PTW PR60020 diode detector and transverse profiles were measured with Gafchromic EBT3 film. Monte Carlo simulations were also performed - both for comparison with experimental data and to further explore the potential of magnetic focusing in silica. For example, beam spot areas (based on the 90% dose contour) were matched at Bragg depth between simulated 100 MeV collimated beams and simulated beams focused by two 400 T/m gradient magnets. Results: Preliminary experimental results show 23% higher peak to entrance dose ratios and flatter spread out Bragg peak plateaus for 8 mm focused beams compared with uncollimated beams. Monte Carlo simulations showed 21% larger peak to entrance ratios and a ∼9 fold more efficient dose to target delivery compared to spot-sized matched collimated beams. Our latest results will be presented. Conclusion: Our results suggest that rare earth focusing magnet assemblies could reduce skin dose and beam number while delivering dose to nominally spherical radiosurgery targets over a much shorter time compared to unfocused beams. Immediate clinical applications include those associated with proton radiosurgery and functional radiosurgery of the brain and spine, however expanded treatment sites can be also envisaged.

  6. [Dementias: diagnostic contribution of imaging and proton magnetic resonance spectroscopy].

    Science.gov (United States)

    Arana, E; Martínez-Granados, B; Marti-Bonmati, L; Martínez-Bisbal, M C; Gil, A; Blasco, C; Celda, B

    2007-06-01

    The objective is analyze the complementarity between 1H magnetic resonance spectroscopy (MRS) and magnetic resonance (MR) imaging in the global diagnosis of Alzheimer's disease (AD) or vascular dementia (VD). We studied 168 patients with cognitive impairment from AD, VD, mild cognitive impairment (MCI) and major depression. All patients were evaluated by brain MR imaging and MRS using two sample volumes localized at right medial temporal gyrus and posterior parietal gyrus. Metabolites analyzed were N-acetylaspartate (NAA), myo-Inositol (mI), Choline (Cho) and creatine (Cr), as standard references for obtaining the Co/Cr, mI/Cr and NAA/Cr ratios. Imaging and spectroscopy alterations were graded from 0 to 4 and the average of both was used to draw ROC and SROC curves. Area under ROC curve (Az) was used as a measure of discriminative ability. Combination of MR imaging and MRS significantly improved AD diagnosis (Global Az: 0.722 vs. MR imaging Az: 0.624; p: 0.003). However, the combination of MR imaging and MRS did not improve VD diagnosis. SROC curve obtained for the diagnosis of global dementia was Az: 0.6658 with 0.67 sensitivity and 0.65 specificity. Combination of both MR techniques significantly improved AD diagnosis versus MR imaging alone. More studies are needed to enhance VD classification. Metabolic data found by MRS can be useful to differentiate cognitive impairment

  7. Determination of scutellarin in breviscapine preparations using quantitative proton nuclear magnetic resonance spectroscopy

    Directory of Open Access Journals (Sweden)

    Zhenzuo Jiang

    2016-04-01

    Full Text Available The objective of the present study was to develop the selection criteria of proton signals for the determination of scutellarin using quantitative nuclear magnetic resonance (qNMR, which is the main bioactive compound in breviscapine preparations for the treatment of cerebrovascular disease. The methyl singlet signal of 3-(trimethylsilylpropionic-2,2,3,3-d4 acid sodium salt was selected as the internal standard for quantification. The molar concentration of scutellarin was determined by employing different proton signals. To obtain optimum proton signals for the quantification, different combinations of proton signals were investigated according to two selection criteria: the recovery rate of qNMR method and quantitative results compared with those obtained with ultra-performance liquid chromatography. As a result, the chemical shift of H-2′ and H-6′ at δ 7.88 was demonstrated as the most suitable signal with excellent linearity range, precision, and recovery for determining scutellarin in breviscapine preparations from different manufacturers, batch numbers, and dosage forms. Hierarchical cluster analysis was employed to evaluate the determination results. The results demonstrated that the selection criteria of proton signals established in this work were reliable for the qNMR study of scutellarin in breviscapine preparations.

  8. Proton magnetic resonance studies in solutions of o- and p-hydroxy benzoic acids in dioxan

    International Nuclear Information System (INIS)

    Arulmozhi, V.; Srinivasa Rao, A.; Balasubramanian, V.

    1990-01-01

    High resolution proton(NMR) studies were carried out in solutions of o- and p-hydroxy benzoic acids(OHBA and PHBA) in dioxan (D) for several solute concentrations in the range of 0.01 to 0.10 mole fraction (mf). The spectra corresponding to OH and COOH protons could be distinguished in solutions of OHBA in D whereas solution of PHBA in D show only peak in the range of chemical shifts attributable to OH and COOH protons. In the solution of OHBA in dioxan the chemical shift of the proton of the hydroxyl group increases with increase of solute concentration and attains a maximum at a solute concentration of 0.04 mf and then decreases with further increase of solute concentration. For the carboxyl group, the chemical shift increase with increase of solute concentration and attians a maximum at 0.08 mf solute concentration. In solutions of PHBA in D the chemical shift of the single line observed increases with increase of solute concentration and attains a maximum at a solute concentration of 0.05 mf. The data are interpreted as due to formation of hydrogen bonds between the molecule of OHBA and PHBA and dioxan. The proton magnetic relaxation studies in the above solutions also confirm the above findings. (author). 6 refs., 5 figs

  9. Design of the dipole and quadrupole magnets of the dedicated proton synchrotron for hadron therapy

    International Nuclear Information System (INIS)

    Kukarnikov, S.I.; Makoveev, V.K.; Minashkin, V.F.; Molodozhentsev, A.Yu.; Shevtsov, V.F.; Sidorov, G.I.

    1998-01-01

    The 2D-calculation results of magnetic elements of the PRAMES (Prague Medical Synchrotron) are presented. This machine is a dedicated accelerator for cancer therapy. The output energy of the beam should be variable in the range 60-220 MeV. The maximum magnetic field of the dipole magnet should be 1.2 T, the maximum magnetic field ramp - less than 8 T/s. The focusing structure of the proton synchrotron consists of 8 dipole and 18 quadrupole magnets. All magnets are laminated to minimize leakage currents. The dipoles are parallel-edge, H-type magnets. The field uniformity should be of the order of ± 1 x 10 -4 in the working area (± 63 mm and ± 27 mm in the horizontal and vertical planes, respectively). The maximum magnetic field on the pole of the quadrupole lenses should be less than 1 T. The gradient uniformity of quadrupole magnets in the working region should be less than ± 3.5 x 10 -4

  10. NuMI proton kicker extraction magnet termination resistor system

    Energy Technology Data Exchange (ETDEWEB)

    Reeves, S.R.; Jensen, C.C.; /Fermilab

    2005-05-01

    The temperature stability of the kicker magnet termination resistor assembly directly affects the field flatness and amplitude stability. Comprehensive thermal enhancements were made to the existing Main Injector resistor assembly design to satisfy NuMI performance specifications. Additionally, a fluid-processing system utilizing Fluorinert{reg_sign} FC-77 high-voltage dielectric was built to precisely control the setpoint temperature of the resistor assembly from 70 to 120F, required to maintain constant resistance during changing operational modes. The Fluorinert{reg_sign} must be continually processed to remove hazardous breakdown products caused by radiation exposure to prevent chemical attack of system components. Design details of the termination resistor assembly and Fluorinert{reg_sign} processing system are described. Early performance results will be presented.

  11. Importance of Proton Magnetic Resonance Spectroscopy in Diagnosis of Brain Tumors

    International Nuclear Information System (INIS)

    Polacek, H.; Zelenak, K.; Bittsansky, M.; Cisarikova, V.; DeRiggo, J.; Tichterova, R.

    2011-01-01

    Most brain tumors are routinely examined by CT and magnetic resonance (MR). MR plays a crucial role in the preoperative diagnosis and postoperative monitoring. In some cases, proton MR spectroscopy (MRS) provides additional diagnostic information to standard MR results. MRS analyzes important cerebral biochemical substances containing choline, N-acetylaspartate and more. We present a case of 42-year old patient with high-grade glioblastoma examined using MRS in addition to MR imaging before and after surgery. (author)

  12. Design summary of the magnet support structures for the proton storage ring injection line upgrade

    International Nuclear Information System (INIS)

    Bernardin, J.D.; Ledford, J.E.; Smith, B.G.

    1997-05-01

    This report summarizes the technical engineering and design issues associated with the Proton Storage Ring (PSR) Injection Line upgrade of the Los Alamos Neutron Science Center (LANSCE). The main focus is on the engineering design calculations of several magnet support structures. The general procedure based upon a set number of design criteria is outlined, followed by a case-by-case summary of the engineering design analyses, reutilization or fabrication callouts and design safety factors

  13. Application of random numbers at computerized simulation of proton magnetic resonance signals

    International Nuclear Information System (INIS)

    Populyakh, S.N.; Sapiga, A.V.

    2006-01-01

    One calculated numerically spectra of proton magnetic resonance of water molecules diffusing along the regular positions in a natrolite. One reached adequate conformity of the experimental and the calculated spectra within wide temperature range including a transition region. To ensure calculations one used generators of the pseudorandom Markov sequences. The numerical analysis, in particular, has shown that at the binary Markov process the time period when physical value remains unchanged is described by the random value with exponential distribution [ru

  14. Medulloblastoma: correlation among findings of conventional magnetic resonance imaging, diffusion-weighted imaging and proton magnetic resonance spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Fonte, Mariana Vieira de Melo da; Otaduy, Maria Concepcion Garcia; Lucato, Leandro Tavares; Reed, Umbertina Conti; Leite, Claudia da Costa [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Hospital das Clinicas. Inst. de Radiologia]. E-mail: mvmfonte@uol.com.br; Costa, Maria Olivia Rodrigues; Amaral, Raquel Portugal Guimaraes [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Faculdade de Medicina. Dept. de Radiologia; Reed, Umbertina Conti [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Faculdade de Medicina. Dept. de Neurologia; Rosemberg, Sergio [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Hospital das Clinicas. Dept. de Patologia

    2008-11-15

    To correlate imaging findings of medulloblastomas at conventional magnetic resonance imaging, diffusion-weighted imaging and proton magnetic resonance spectroscopy, comparing them with data in the literature. Preoperative magnetic resonance imaging studies of nine pediatric patients with histologically confirmed medulloblastomas (eight desmoplastic medulloblastoma, and one giant cell medulloblastoma) were retrospectively reviewed, considering demographics as well as tumors characteristics such as localization, morphology, signal intensity, contrast-enhancement, dissemination, and diffusion-weighted imaging and spectroscopy findings. In most of cases the tumors were centered in the cerebellar vermis (77.8%), predominantly solid (88.9%), hypointense on T 1-weighted images and intermediate/hyperintense on T 2-FLAIR-weighted images, with heterogeneous enhancement (100%), tumor dissemination/extension (77.8%) and limited water molecule mobility (100%). Proton spectroscopy acquired with STEAM technique (n = 6) demonstrated decreased Na a / Cr ratio (83.3%) and increased Co/Cr (100%) and ml/Cr (66.7%) ratios; and with PRESS technique (n = 7) demonstrated lactate peak (57.1%). Macroscopic magnetic resonance imaging findings in association with biochemical features of medulloblastomas have been useful in the differentiation among the most frequent posterior fossa tumors. (author)

  15. Medulloblastoma: correlation among findings of conventional magnetic resonance imaging, diffusion-weighted imaging and proton magnetic resonance spectroscopy

    International Nuclear Information System (INIS)

    Fonte, Mariana Vieira de Melo da; Otaduy, Maria Concepcion Garcia; Lucato, Leandro Tavares; Reed, Umbertina Conti; Leite, Claudia da Costa; Costa, Maria Olivia Rodrigues; Amaral, Raquel Portugal Guimaraes; Reed, Umbertina Conti; Rosemberg, Sergio

    2008-01-01

    To correlate imaging findings of medulloblastomas at conventional magnetic resonance imaging, diffusion-weighted imaging and proton magnetic resonance spectroscopy, comparing them with data in the literature. Preoperative magnetic resonance imaging studies of nine pediatric patients with histologically confirmed medulloblastomas (eight desmoplastic medulloblastoma, and one giant cell medulloblastoma) were retrospectively reviewed, considering demographics as well as tumors characteristics such as localization, morphology, signal intensity, contrast-enhancement, dissemination, and diffusion-weighted imaging and spectroscopy findings. In most of cases the tumors were centered in the cerebellar vermis (77.8%), predominantly solid (88.9%), hypointense on T 1-weighted images and intermediate/hyperintense on T 2-FLAIR-weighted images, with heterogeneous enhancement (100%), tumor dissemination/extension (77.8%) and limited water molecule mobility (100%). Proton spectroscopy acquired with STEAM technique (n = 6) demonstrated decreased Na a / Cr ratio (83.3%) and increased Co/Cr (100%) and ml/Cr (66.7%) ratios; and with PRESS technique (n = 7) demonstrated lactate peak (57.1%). Macroscopic magnetic resonance imaging findings in association with biochemical features of medulloblastomas have been useful in the differentiation among the most frequent posterior fossa tumors. (author)

  16. Study of resonant magnet exciting system for the 3 GeV proton synchrotron

    Energy Technology Data Exchange (ETDEWEB)

    Koseki, Shoichiro; Zhang, Fengqing; Watanabe, Yasuhiro; Tani, Norio [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Adachi, Toshikazu; Someya, Hirohiko [High Energy Accelerator Research Organization, Tsukuba, Ibaraki (Japan)

    2001-07-01

    Exciting system for magnets of the 3 GeV Proton synchrotron is under consideration. A resonant exciting system is studied, and two type of power supply are compared. One is a parallel supply that is used generally. Another is a modified series supply. Either of them uses IGBT sinusoidal converters. Capacity of the power converter of the series supply for bending magnets becomes 28.8 MVAp. This is lager more than twice compared with the parallel supply. In the other hand, the series supply has good control performance and flexibility. More study is necessary to decide finally. (author)

  17. Upgrade of the CERN Proton Synchrotron Booster bending magnets for 2 GeV Operation

    CERN Document Server

    Newborough, A; Chritin, R

    2013-01-01

    Since its first operation in 1972 at an energy of 800MeV the CERN Proton Synchrotron Booster, which consists of 4 super imposed synchrotrons, has seen two upgrades: once to 1.0 GeV in 1988 and then to 1.4 GeV in 1999. During this time the main magnets of the machine have remained largely unchanged with small differences (<1%) between the inner and outer gaps of the main bending magnet fields being compensated by trim power supplies. The future upgrade of the machine will demand to extract protons at an energy of 2.0 GeV and require almost double the original dipole field. At this field, due to saturation effects, the inner and outer gaps of the main dipole magnets will differ by up to 4%. This paper presents the design and implementation of a modification of the magnetic circuit strongly reducing these effects. We also discuss the results of experimental tests concerning the effects on field quality and eddy current transients, including the implications for the real-time magnetic field measurement system ...

  18. Recoil Distance Method lifetime measurements via gamma-ray and charged-particle spectroscopy at NSCL

    Science.gov (United States)

    Voss, Philip Jonathan

    The Recoil Distance Method (RDM) is a well-established technique for measuring lifetimes of electromagnetic transitions. Transition matrix elements derived from the lifetimes provide valuable insight into nuclear structure. Recent RDM investigations at NSCL present a powerful new model-independent tool for the spectroscopy of nuclei with extreme proton-to-neutron ratios that exhibit surprising behavior. Neutron-rich 18C is one such example, where a small B(E2; 2+1 → 0+gs) represented a dramatic shift from the expected inverse relationship between the B(E2) and 2+1 excitation energy. To shed light on the nature of this quadrupole excitation, the RDM lifetime technique was applied with the Koln/NSCL plunger. States in 18C were populated by the one-proton knockout reaction of a 19N secondary beam. De-excitation gamma rays were detected with the Segmented Germanium Array in coincidence with reaction residues at the focal plane of the S800 Magnetic Spectrometer. The deduced B(E2) and excitation energy were both well described by ab initio no-core shell model calculations. In addition, a novel extension of RDM lifetime measurements via charged-particle spectroscopy of exotic proton emitters has been investigated. Substituting the reaction residue degrader of the Koln/NSCL plunger with a thin silicon detector permits the study of short-lived nuclei beyond the proton dripline. A proof of concept measurement of the mean lifetime of the two-proton emitter 19Mg was conducted. The results indicated a sub-picosecond lifetime, one order of magnitude smaller than the published results, and validate this new technique for lifetime measurements of charged-particle emitters.

  19. Structure of events with a particle at large transverse momentum in proton-proton collisions at the CERN ISR

    International Nuclear Information System (INIS)

    Herr, W.F.

    1985-01-01

    The structure of events with a particle with large transverse momentum has been studied for proton-proton collisions at a centre-of-mass energy of √s=62.2 GeV. The experiment was performed with the Split-Field-Magnet detector at the CERN Intersecting Storage Rings and events were recorded with high-psub(T) particles with psub(T)>2 GeV/c produced at polar angles around 45 0 and 20 0 . The distributions of charged particles in the jet recoiling against the high-psub(T) particle have been measured as a function of the fragmentation variable xsub(E)=psub(T)/psub(T)sup(tri). The production of high-psub(T) particles is usually interpreted in the quark parton model as the hard collision of proton constituents. The asymmetry and charge composition of the recoil jet and their correlation with the flavour of the high-psub(T) particle supports this qualitative picture. Model calculations using first order Quantum Chromodynamics (QCD) and phenomenological fragmentation model cannot explain the particle distribution in the recoil jet. (orig.) [de

  20. Proton magnetic spectroscopy agreed better with magnetic resonance image to lateralization of epileptogenic zone than with surface electroencephalography

    Directory of Open Access Journals (Sweden)

    Ricardo Andre Amorim Leite

    2013-09-01

    Full Text Available Objective To analyze the agreement rate of proton magnetic spectroscopy with magnetic resonance image (MRI and surface electroence-phalography (EEG in extratemporal neocortical epilepsies. Methods A cross-sectional study, type series of cases included 33 patients, age range 13–59 years old, of both gender, presenting structural alteration identified by MRI (75.8% or by neurophysiologic techniques (72.7%. The variables were alterations of N-acetyl-aspartate/choline, N-acetyl-aspartate/creatine, choline/creatine, and N-acetyl-aspartate/cho-line+creatine coefficient of asymmetry. Results Agreement rates of lateralization by coefficient of asymmetry of NAA/Cho, NAA/Cr, Co/Cr, and NAA/Cho+Cr with MRI, independent of alteration of surface EEG, were equal to 93.3, 57.9, 15.4, and 93.3%, respectively, modifying to 100, 33.3, 0, and 100%, in 16 patients, with lateralization agreement of MRI and surface EEG. Conclusion Proton magnetic spectroscopy agreed better with MRI to lateralization of epileptogenic zone than with surface EEG.

  1. An experimentally derived magnetic moment for the f7/2 proton in trans-lead nuclei

    International Nuclear Information System (INIS)

    Stuchbery, A.E.; Byrne, A.P.; Dracoulis, G.D.

    1992-12-01

    An experimental value for the g-factor of the 1f 7/2 proton is derived from the measured magnetic moment of the 14 + 1 state in 214 Ra using the multiparticle octupole coupling model. The result, g(f 7/2 ) = 1.41(2), is smaller than anticipated by theories which assume first order core polarization corrections to the proton spin g-factor together with an anomalous orbital magnetism of about 0.12. The experimental value suggests the proton spin g-factor g s may be quenched, in this orbital, to about half the bare-nucleon value, similar to that found for the 0h 9/2 and 0i 13/2 protons, or, alternatively, that the anomalous orbital magnetism is much reduced for the 1f 7/2 orbital. 15 refs., 2 tabs

  2. Proton NMR for Measuring Quantum Level Crossing in the Magnetic Molecular Ring Fe10

    International Nuclear Information System (INIS)

    Julien, M.; Jang, Z.H.; Borsa, F.; Julien, M.; Lascialfari, A.; Borsa, F.; Horvatic, M.; Caneschi, A.; Gatteschi, D.

    1999-01-01

    The proton nuclear spin-lattice relaxation rate 1/T 1 has been measured as a function of temperature and magnetic field (up to 15thinspthinspT) in the molecular magnetic ring Fe 10 ( OCH 3 ) 20 (O 2 CCH 2 Cl) 10 (Fe10). Striking enhancement of 1/T 1 is observed around magnetic field values corresponding to a crossing between the ground state and the excited states of the molecule. We propose that this is due to a cross-relaxation effect between the nuclear Zeeman reservoir and the reservoir of the Zeeman levels of the molecule. This effect provides a powerful tool to investigate quantum dynamical phenomena at level crossing. copyright 1999 The American Physical Society

  3. Magnetic measurements on the ring dipoles and quadrupoles for the Los Alamos proton storage ring

    International Nuclear Information System (INIS)

    Schermer, R.I.; Blind, B.; Jason, A.J.; Sawyer, G.A.

    1985-01-01

    This paper discusses magnetic measurements and shimming performed on the ring dipoles and quadrupoles for the Los Alamos Proton Storage Ring (PSR). For the dipoles, point-by-point field maps were obtained using a search coil that could be scanned over a three-dimensional grid. By appropriate machining of removable end blocks, all magnet lengths were adjusted to within 0.01% of a nominal value and all integrated multipoles were set within tolerance. Integrated fields of 20 PSR quadrupoles were measured using a rotating ''Morgan Coil'' and a digital spectrum analyzer. The magnets were shimmed to specifications by adjusting steel bolts threaded through the field clamps. 3 refs., 5 figs., 4 tabs

  4. Uniform magnetic field in the bending magneto for the compact proton synchrotron

    CERN Document Server

    Tokura, S; Miyauchi, Y; Nakajima, S; Arakawa, M

    2003-01-01

    Radiation therapy using high-energy protons is a very effective method of cancer treatment. To attain the necessary beam energy for cancer therapy using a very compact synchrotron, the magnetic field of the normal-conductive bending magnet must be excited up to 3-5 T. However, increasing the field up to 4 T produces a sextupole component in the field. The sextupole component can be reduced by changing the geometry of the coil, but establishing the optimal geometry is very time-consuming. A new optimization method has been developed to establish the uniform field in the bending magnet. As a result, the optimal geometry is obtained with less calculation time. (author)

  5. Exclusive ρ0 production measured with the HERMES recoil detector

    International Nuclear Information System (INIS)

    Perez Benito, Roberto Francisco

    2010-12-01

    The Hermes experiment (HERa MEasurement of Spin) at Desy was designed to study the spin structure of the nucleon in semi-inclusive deep inelastic scattering. The internal structure of the nucleon has been investigated in detail and it has been measured that the intrinsic quark spin contribution is only about 30% of the total spin of the nucleon. A formalism to describe the internal structure of the nucleon called Generalised Patron Distributions (GPDs) was developed recently to understand the fundamental structure of the nucleon. These GPDs can be accessed by the measurement of hard exclusive reactions and hard exclusive processes that can be understood in terms of GPDs. The accumulated Hermes data offer access to GPDs in different combinations of beam charge and beam and target helicity asymmetries. To improve exclusivity and to enhance the resolution of kinematic variables to study hard exclusive processes which provide access to the GPDs and hence to the orbital angular momentum of the quarks, in January 2006 a Recoil Detector was installed that surrounded the internal gas target of the Hermes experiment. The Hermes Recoil Detector consisted of three components: a silicon strip detector inside the vacuum, a scintillating fiber tracker and the photon detector. All three detectors were located inside a solenoidal magnet which provided a 1T longitudinal magnetic field. The Recoil Detector improves the selection of exclusive events by a direct measurement of the momentum and track position of the recoiling particle as well as by rejecting non-exclusive background. This detector was an ideal novel tool to combine energy and position measurements for charged particles in a momentum range of 0.1 to 1.4 GeV/c. The Recoil Detector was fully commissioned and operating. Data was taken continuously until the final Hera shutdown in July of 2007. In this thesis we report on the performance of the Recoil Detector and more specifically about the scintillating fiber tracker

  6. Influence of the interface on the magnetic properties of NiZn ferrite thin films treated by proton irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, X.D. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education, Lanzhou University, Lanzhou 730000 (China); Guo, D.W. [Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education, Lanzhou University, Lanzhou 730000 (China); Zhang, C.H., E-mail: c.h.zhang@impcas.ac.cn [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Fan, X.L.; Chai, G.Z. [Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education, Lanzhou University, Lanzhou 730000 (China); Xue, D.S., E-mail: xueds@lzu.edu.cn [Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education, Lanzhou University, Lanzhou 730000 (China)

    2015-09-01

    In order to systematically investigate the influence of the interface on the magnetic properties, polycrystalline NiZn ferrite thin films were irradiated with 60 keV proton in the dose range from 5 × 10{sup 12} to 5 × 10{sup 16} ions/cm{sup 2}. A non-destructive approach by proton irradiation was found to finely adjust the magnetic properties of polycrystalline NiZn ferrite thin films such as coercivity, perpendicular magnetic anisotropy as well as the effective g value. The coercivity is about 725 Oe for high proton dose ferrite, which is twice larger than the unirradiated one. The ferromagnetic resonance measurements indicated that perpendicular magnetic anisotropy and the effective g value increase with the irradiation dose. Our finding indicates that all modifications of these magnetic properties were associated with the change of interface due to the diffusion and the stress induced by proton irradiation. The change of the effective g value is a result of lattice expansion and the decrease of the magnetic dipole interaction between the columnar grains. This work provides a feasible way to tailor the magnetic properties of thin films by ion irradiation and promotes investigations for the stability of magnetic thin film devices in space or unclear radiation environments.

  7. A superconducting magnet mandrel with minimum symmetry laminations for proton therapy

    Science.gov (United States)

    Caspi, S.; Arbelaez, D.; Brouwer, L.; Dietderich, D. R.; Felice, H.; Hafalia, R.; Prestemon, S.; Robin, D.; Sun, C.; Wan, W.

    2013-08-01

    The size and weight of ion-beam cancer therapy gantries are frequently determined by a large aperture, curved, ninety degree, dipole magnet. The higher fields achievable with superconducting technology promise to greatly reduce the size and weight of this magnet and therefore also the gantry as a whole. This paper reports advances in the design of winding mandrels for curved, canted cosine-theta (CCT) magnets in the context of a preliminary magnet design for a proton gantry. The winding mandrel is integral to the CCT design and significantly affects the construction cost, stress management, winding feasibility, eddy current power losses, and field quality of the magnet. A laminated mandrel design using a minimum symmetry in the winding path is introduced and its feasibility demonstrated by a rapid prototype model. Piecewise construction of the mandrel using this laminated approach allows for increased manufacturing techniques and material choices. Sectioning the mandrel also reduces eddy currents produced during field changes accommodating the scan of beam energies during treatment. This symmetry concept can also greatly reduce the computational resources needed for 3D finite element calculations. It is shown that the small region of symmetry forming the laminations combined with periodic boundary conditions can model the entire magnet geometry disregarding the ends.

  8. The HERMES recoil detector. Particle identification and determination of detector efficiency of the scintillating fiber tracker

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Xianguo

    2009-11-15

    HERMES is a fixed target experiment using the HERA 27.6 GeV polarized electron/positron beams. With the polarized beams and its gas targets, which can be highly polarized, HERMES is dedicated to study the nucleon spin structure. One of its current physics programs is to measure deeply virtual Compton scattering (DVCS). In order to detect the recoiling proton the Recoil Detector was installed in the target region in the winter of 2005, taking data until the HERA-shutdown in the summer of 2007. The Recoil Detector measured energy loss of the traversing particles with its sub-detectors, including the silicon strip detector and the scintillating fiber tracker. This enables particle identification for protons and pions. In this work a systematic particle identification procedure is developed, whose performance is quantified. Another aspect of this work is the determination of the detector efficiency of the scintillating fiber tracker. (orig.)

  9. Strange magnetic form factor of the proton at $Q^2 = 0.23$ GeV$^2$

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Ping; Leinweber, Derek; Thomas, Anthony; Young, Ross

    2009-06-01

    We determine the $u$ and $d$ quark contributions to the proton magnetic form factor at finite momentum transfer by applying chiral corrections to quenched lattice data. Heavy baryon chiral perturbation theory is applied at next to leading order in the quenched, and full QCD cases for the valence sector using finite range regularization. Under the assumption of charge symmetry these values can be combined with the experimental values of the proton and neutron magnetic form factors to deduce a relatively accurate value for the strange magnetic form factor at $Q^2=0.23$ GeV$^2$, namely $G_M^s=-0.034 \\pm 0.021$ $\\mu_N$.

  10. 3D microscopy of hydrogen and magnetic force on proton implanted microstructures in graphite

    International Nuclear Information System (INIS)

    Reichart, P.; Cluitmans, J.F.J.; Pakes, C.; Orbons, S.; Jamieson, D.N.

    2005-01-01

    We investigated the depth dependence of magnetic signals in proton irradiated graphite using a tilted microspot implantation followed by combined AFM/MFM analysis. This study is motivated by the not yet independently reproduced discovery of ferromagnetism in carbon materials created by proton irradiation. We present results of 3D hydrogen analysis of pristine and irradiated highly oriented pyrolytic graphite (HOPG). These results, previously presented in collaboration with universities in Leipzig and Munich, are summarized here and reveal a hydrogen level in pristine HOPG less than 0.3 at-ppm and that 2.25 MeV implanted hydrogen is located within a peak confined to the end of range with no evidence of diffusion broadening. For implanted microspots, up to 40 at-% of the implanted hydrogen is not detected, providing support for lateral hydrogen diffusion. Up to 10 16 H-atoms/cm 2 are detected in the near-surface region on all samples, which has not yet been considered in possible mechanisms for creation of ferromagnetism. As theoretical models propose that hydrogen could play a major role in carbon ferromagnetism, this result raises the hypothesis for an effect restricted to the surface. Our preliminary data on magnetic force microscopy of tilted implants show a strong magnetic phase shift localized on the beam entrance point only. (author). 14 refs., 5 figs

  11. The effect of polymer coatings on proton transverse relaxivities of aqueous suspensions of magnetic nanoparticles

    International Nuclear Information System (INIS)

    Carroll, Matthew R J; House, Michael J; Woodward, Robert C; St Pierre, Timothy G; Huffstetler, Phillip P; Miles, William C; Goff, Jonathon D; Davis, Richey M; Riffle, Judy S

    2011-01-01

    Iron oxide magnetic nanoparticles are good candidates for magnetic resonance imaging (MRI) contrast agents due to their high magnetic susceptibilities. Here we investigate 19 polyether-coated magnetite nanoparticle systems comprising three series. All systems were synthesized from the same batch of magnetite nanoparticles. A different polyether was used for each series. Each series comprised systems with systematically varied polyether loadings per particle. A highly significant (p < 0.0001) linear correlation (r = 0.956) was found between the proton relaxivity and the intensity-weighted average diameter measured by dynamic light scattering in the 19 particle systems studied. The intensity-weighted average diameter measured by dynamic light scattering is sensitive to small number fractions of larger particles/aggregates. We conclude that the primary effect leading to differences in proton relaxivity between systems arises from the small degree of aggregation within the samples, which appears to be determined by the nature of the polymer and, for one system, the degree of polymer loading of the particles. For the polyether coatings used in this study, any changes in relaxivity from differences in water exclusion or diffusion rates caused by the polymer are minor in comparison with the changes in relaxivity resulting from variations in the degree of aggregation.

  12. The effect of polymer coatings on proton transverse relaxivities of aqueous suspensions of magnetic nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Carroll, Matthew R J; House, Michael J; Woodward, Robert C; St Pierre, Timothy G [School of Physics, University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009 (Australia); Huffstetler, Phillip P; Miles, William C; Goff, Jonathon D; Davis, Richey M; Riffle, Judy S, E-mail: stpierre@physics.uwa.edu.au [Macromolecules and Interfaces Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 (United States)

    2011-08-12

    Iron oxide magnetic nanoparticles are good candidates for magnetic resonance imaging (MRI) contrast agents due to their high magnetic susceptibilities. Here we investigate 19 polyether-coated magnetite nanoparticle systems comprising three series. All systems were synthesized from the same batch of magnetite nanoparticles. A different polyether was used for each series. Each series comprised systems with systematically varied polyether loadings per particle. A highly significant (p < 0.0001) linear correlation (r = 0.956) was found between the proton relaxivity and the intensity-weighted average diameter measured by dynamic light scattering in the 19 particle systems studied. The intensity-weighted average diameter measured by dynamic light scattering is sensitive to small number fractions of larger particles/aggregates. We conclude that the primary effect leading to differences in proton relaxivity between systems arises from the small degree of aggregation within the samples, which appears to be determined by the nature of the polymer and, for one system, the degree of polymer loading of the particles. For the polyether coatings used in this study, any changes in relaxivity from differences in water exclusion or diffusion rates caused by the polymer are minor in comparison with the changes in relaxivity resulting from variations in the degree of aggregation.

  13. Characterization of the ELIMED Permanent Magnets Quadrupole system prototype with laser-driven proton beams

    Science.gov (United States)

    Schillaci, F.; Pommarel, L.; Romano, F.; Cuttone, G.; Costa, M.; Giove, D.; Maggiore, M.; Russo, A. D.; Scuderi, V.; Malka, V.; Vauzour, B.; Flacco, A.; Cirrone, G. A. P.

    2016-07-01

    Laser-based accelerators are gaining interest in recent years as an alternative to conventional machines [1]. In the actual ion acceleration scheme, energy and angular spread of the laser-driven beams are the main limiting factors for beam applications and different solutions for dedicated beam-transport lines have been proposed [2,3]. In this context a system of Permanent Magnet Quadrupoles (PMQs) has been realized [2] by INFN-LNS (Laboratori Nazionali del Sud of the Instituto Nazionale di Fisica Nucleare) researchers, in collaboration with SIGMAPHI company in France, to be used as a collection and pre-selection system for laser driven proton beams. This system is meant to be a prototype to a more performing one [3] to be installed at ELI-Beamlines for the collection of ions. The final system is designed for protons and carbons up to 60 MeV/u. In order to validate the design and the performances of this large bore, compact, high gradient magnetic system prototype an experimental campaign have been carried out, in collaboration with the group of the SAPHIR experimental facility at LOA (Laboratoire d'Optique Appliquée) in Paris using a 200 TW Ti:Sapphire laser system. During this campaign a deep study of the quadrupole system optics has been performed, comparing the results with the simulation codes used to determine the setup of the PMQ system and to track protons with realistic TNSA-like divergence and spectrum. Experimental and simulation results are good agreement, demonstrating the possibility to have a good control on the magnet optics. The procedure used during the experimental campaign and the most relevant results are reported here.

  14. Metabolic imaging of human kidney triglyceride content: reproducibility of proton magnetic resonance spectroscopy.

    Directory of Open Access Journals (Sweden)

    Sebastiaan Hammer

    Full Text Available OBJECTIVE: To assess the feasibility of renal proton magnetic resonance spectroscopy for quantification of triglyceride content and to compare spectral quality and reproducibility without and with respiratory motion compensation in vivo. MATERIALS AND METHODS: The Institutional Review Board of our institution approved the study protocol, and written informed consent was obtained. After technical optimization, a total of 20 healthy volunteers underwent renal proton magnetic resonance spectroscopy of the renal cortex both without and with respiratory motion compensation and volume tracking. After the first session the subjects were repositioned and the protocol was repeated to assess reproducibility. Spectral quality (linewidth of the water signal and triglyceride content were quantified. Bland-Altman analyses and a test by Pitman were performed. RESULTS: Linewidth changed from 11.5±0.4 Hz to 10.7±0.4 Hz (all data pooled, p<0.05, without and with respiratory motion compensation respectively. Mean % triglyceride content in the first and second session without respiratory motion compensation were respectively 0.58±0.12% and 0.51±0.14% (P = NS. Mean % triglyceride content in the first and second session with respiratory motion compensation were respectively 0.44±0.10% and 0.43±0.10% (P = NS between sessions and P = NS compared to measurements with respiratory motion compensation. Bland-Altman analyses showed narrower limits of agreement and a significant difference in the correlated variances (correlation of -0.59, P<0.05. CONCLUSION: Metabolic imaging of the human kidney using renal proton magnetic resonance spectroscopy is a feasible tool to assess cortical triglyceride content in humans in vivo and the use of respiratory motion compensation significantly improves spectral quality and reproducibility. Therefore, respiratory motion compensation seems a necessity for metabolic imaging of renal triglyceride content in vivo.

  15. PMR spectra and proton magnetic relaxation in uranyl nitrate-hexamethylenetetramine-urea-water gel forming system

    International Nuclear Information System (INIS)

    Vashman, A.A.; Pronin, I.S.; Brylkina, T.V.; Makarov, V.M.

    1979-01-01

    PMR spectra and proton relaxation in the nitrate-hexamethylenetetramine (HMTA)-urea-water gelling system are studied. According to PMR spectra products of HMTA chemical decomposition, which are supposed to be formed in the gelling process, have not been detected. Effect of hydrogen exchange upon PMR spectra of urea and water in the presence of HMTA and uranyl nitrate is studied. Periods of spin-lattice and spin-spin relaxations of water and HMTA protons in gels on the base of uranyl nitrate are found. Data on relaxation permitted to make qualitative conclusions upon the gel structure and HMTA molecule distribution over ''phases''. Nonproducibility of the results of period measurements in gels is the result of nonproducibility of the gel structure in the course of transformation of liquid solution into gel. Temperature dependences of proton relaxation in the gels are impossible yet to interpret on the basis of temperature behaviour of one correlation period, controlling dipole-dipole nuclear magnetic relaxation, and obeying Arrhenius dependence on the temperature

  16. Elastic neutron-proton differential cross section at 647 MeV

    International Nuclear Information System (INIS)

    Evans, M.L.

    1979-04-01

    The differential cross section for n-p elastic scattering in the angular range 51 0 was measured with high statistical accuracy using the 647 MeV monoenergetic neutron beam of the Los Alamos Meson Physics Facility. A proton recoil magnetic spectrometer was used for momentum analysis of the charge exchange protons from the reaction n+p→p+n. Absolute normalization of the cross section was established to within 7% using existing cross section data for the reaction p+p→π + +d. The results differ significantly from previous Dubna and PPA cross sections but agree well with recent Saclay data except at extreme backward angles. 41 references

  17. Measurements of beam current density and proton fraction of a permanent-magnet microwave ion source

    Energy Technology Data Exchange (ETDEWEB)

    Waldmann, Ole; Ludewigt, Bernhard [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720 (United States)

    2011-11-15

    A permanent-magnet microwave ion source has been built for use in a high-yield, compact neutron generator. The source has been designed to produce up to 100 mA of deuterium and tritium ions. The electron-cyclotron resonance condition is met at a microwave frequency of 2.45 GHz and a magnetic field strength of 87.5 mT. The source operates at a low hydrogen gas pressure of about 0.15 Pa. Hydrogen beams with a current density of 40 mA/cm{sup 2} have been extracted at a microwave power of 450 W. The dependence of the extracted proton beam fraction on wall materials and operating parameters was measured and found to vary from 45% for steel to 95% for boron nitride as a wall liner material.

  18. Measurements of beam current density and proton fraction of a permanent-magnet microwave ion source.

    Science.gov (United States)

    Waldmann, Ole; Ludewigt, Bernhard

    2011-11-01

    A permanent-magnet microwave ion source has been built for use in a high-yield, compact neutron generator. The source has been designed to produce up to 100 mA of deuterium and tritium ions. The electron-cyclotron resonance condition is met at a microwave frequency of 2.45 GHz and a magnetic field strength of 87.5 mT. The source operates at a low hydrogen gas pressure of about 0.15 Pa. Hydrogen beams with a current density of 40 mA/cm(2) have been extracted at a microwave power of 450 W. The dependence of the extracted proton beam fraction on wall materials and operating parameters was measured and found to vary from 45% for steel to 95% for boron nitride as a wall liner material. © 2011 American Institute of Physics

  19. Monitoring temozolomide treatment of low-grade glioma with proton magnetic resonance spectroscopy

    DEFF Research Database (Denmark)

    Murphy, P. S.; Viviers, L; Abson, C

    2004-01-01

    Assessment of low-grade glioma treatment response remains as much of a challenge as the treatment itself. Proton magnetic resonance spectroscopy ((1)H-MRS) and imaging were incorporated into a study of patients receiving temozolomide therapy for low-grade glioma in order to evaluate and monitor...... tumour metabolite and volume changes during treatment. Patients (n=12) received oral temozolomide (200 mg m(-2) day(-1)) over 5 days on a 28-day cycle for 12 cycles. Response assessment included baseline and three-monthly magnetic resonance imaging studies (pretreatment, 3, 6, 9 and 12 months) assessing...... months, a significant reduction in the mean choline signal was observed compared with the pretreatment (P=0.035) and 3-month scan (P=0.021). The reduction in the tumour choline/water signal paralleled tumour volume change and may reflect the therapeutic effect of temozolomide...

  20. Methylmalonic aciduria and propionic acidaemia studied by proton nuclear magnetic resonance spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Iles, R A; Hind, A J; Chalmers, R A

    1986-12-15

    Proton nuclear magnetic resonance spectroscopy has been used to monitor changes in urinary metabolites in a patient with propionic acidaemia over a period of 10 months and in a patient with methylmalonic aciduria over a period of 11 days. Results could be obtained within 5-10 min of sample receipt. In the spectra on the patient with propionic acidaemia not only could fluctuations in 3-hydroxypropionate and propionylglycine excretion be followed, but also variations in creatine, glycine and betaine, which were often present at millimolar concentrations. The patient with methylmalonic aciduria had an acute episode of severe ketoacidosis during which the glycine excretion fell but creatine excretion rose and then fell on recovery from the episode. The changes in the creatine excretion may reflect disorders in intracellular energy supply. Nuclear magnetic resonance is a powerful technique for monitoring metabolic perturbations in the organic acidurias in 'real-time', allowing the planning and evaluation of therapy. (Auth.). 18 refs.; 4 figs.; 3 tabs.

  1. Methylmalonic aciduria and propionic acidaemia studied by proton nuclear magnetic resonance spectroscopy

    International Nuclear Information System (INIS)

    Iles, R.A.; Hind, A.J.; Chalmers, R.A.

    1986-01-01

    Proton nuclear magnetic resonance spectroscopy has been used to monitor changes in urinary metabolites in a patient with propionic acidaemia over a period of 10 months and in a patient with methylmalonic aciduria over a period of 11 days. Results could be obtained within 5-10 min of sample receipt. In the spectra on the patient with propionic acidaemia not only could fluctuations in 3-hydroxypropionate and propionylglycine excretion be followed, but also variations in creatine, glycine and betaine, which were often present at millimolar concentrations. The patient with methylmalonic aciduria had an acute episode of severe ketoacidosis during which the glycine excretion fell but creatine excretion rose and then fell on recovery from the episode. The changes in the creatine excretion may reflect disorders in intracellular energy supply. Nuclear magnetic resonance is a powerful technique for monitoring metabolic perturbations in the organic acidurias in 'real-time', allowing the planning and evaluation of therapy. (Auth.)

  2. Magnetic sublevel population in 1s-2p excitation of helium by fast electrons and protons

    Energy Technology Data Exchange (ETDEWEB)

    Godunov, A.L.; McGuire, J.H. [Department of Physics, Tulane University, New Orleans, LA (United States); Merabet, H.; Bruch, R.; Hanni, J. [Department of Physics, University of Nevada Reno, Reno, NV (United States); Schipakov, V.S. [Troitsk Institute for Innovation and Fusion Research, Troitsk, (Russian Federation)

    2001-07-14

    We report experimental and theoretical results for the magnetic sublevel population of the helium atom in collisions with fast (v{sub i}=3-9 au) electrons and protons. Cross sections for excitation of magnetic sublevels with M=0 and {+-}1 have been obtained using polarization measurements of emitted radiation in combination with differential cross sections. Calculations have been carried out using the expansion of the transition amplitude in the Born series over the projectile-target interaction through the second order. Results of calculations are in agreement with experimental data. We find that the particle-antiparticle Z{sup {+-}} difference exceeds the statistical error of measurement up to collision velocities v{sub i}{approx}6 au for excitation of sublevels with M=0. (author)

  3. Non-destructive ripeness sensing by using proton NMR [Nuclear Magnetic Resonance

    International Nuclear Information System (INIS)

    Cho, Seong In; Krutz, G.W.; Stroshine, R.L.

    1990-01-01

    More than 80 kinds of fruits and vegetables are available in the United States. But only about 6 of them have their quality standards (Dull, 1986). In the 1990 Fresh Trends survey (Zind, 1990), consumers were asked to rate 16 characteristics important to their decision to purchase fresh produce. The four top ranking factors were ripeness/freshness, taste/flavor, appearance/condition and nutritional value. Of these surveyed, 96% rated ripeness/freshness as extremely important or very important. Therefore, the development of reliable grading or sorting techniques for fresh commodities is essential. Determination of fruit quality often involves cutting and tasting. Non-destructive quality control in fruit and vegetables is a goal of growers and distributors, as well as the food processing industry. Many nondestructive techniques have been evaluated including soft x-ray, optical transmission, near infrared radiation, and machine vision. However, there are few reports of successful non-destructive measurement of sugar content directly in fruit. Higher quality fruit could be harvested and available to consumers if a nondestructive sensor that detects ripeness level directly by measuring sugar content were available. Using proton Nuclear Magnetic Resonance (NMR) principle is the possibility. A nondestructive ripeness (or sweetness) sensor for fruit quality control can be developed with the proton NMR principle (Cho, 1989). Several feasibility studies were necessary for the ripeness sensor development. Main objectives in this paper was to investigate the feasibilities (1) to detect ripeness (or sweetness level) of raw fruit tissue with an high resolution proton NMR spectroscopy (200 MHz) and (2) to measure sugar content of intact fruit with a low resolution proton NMR spectroscopy (10 MHz). 7 refs., 4 figs

  4. Non-destructive Ripeness Sensing by Using Proton NMR [Nuclear Magnetic Resonance

    Science.gov (United States)

    Cho, Seong In; Krutz, G. W.; Stroshine, R. L.; Bellon, V.

    1990-01-01

    More than 80 kinds of fruits and vegetables are available in the United States. But only about 6 of them have their quality standards (Dull, 1986). In the 1990 Fresh Trends survey (Zind, 1990), consumers were asked to rate 16 characteristics important to their decision to purchase fresh produce. The four top ranking factors were ripeness/freshness, taste/flavor, appearance/condition and nutritional value. Of these surveyed, 96% rated ripeness/freshness as extremely important or very important. Therefore, the development of reliable grading or sorting techniques for fresh commodities is essential. Determination of fruit quality often involves cutting and tasting. Non-destructive quality control in fruit and vegetables is a goal of growers and distributors, as well as the food processing industry. Many nondestructive techniques have been evaluated including soft x-ray, optical transmission, near infrared radiation, and machine vision. However, there are few reports of successful non-destructive measurement of sugar content directly in fruit. Higher quality fruit could be harvested and available to consumers if a nondestructive sensor that detects ripeness level directly by measuring sugar content were available. Using proton Nuclear Magnetic Resonance (NMR) principle is the possibility. A nondestructive ripeness (or sweetness) sensor for fruit quality control can be developed with the proton NMR principle (Cho, 1989). Several feasibility studies were necessary for the ripeness sensor development. Main objectives in this paper was to investigate the feasibilities (1) to detect ripeness (or sweetness level) of raw fruit tissue with an high resolution proton NMR spectroscopy (200 MHz) and (2) to measure sugar content of intact fruit with a low resolution proton NMR spectroscopy (10 MHz).

  5. Lactate quantification by proton magnetic resonance spectroscopy using a clinical MRI machine: a basic study

    International Nuclear Information System (INIS)

    Isobe, T.; Muraishi, H.; Matsumura, A.; Kawamura, H.; Shibata, Y.; Anno, I.; Minami, M.

    2007-01-01

    The purpose of this study was to establish quantification method of lactate concentration by proton magnetic resonance spectroscopy (MRS) carried out using a conventional 1.5-T MRI machine. We used a lactate phantom with known concentrations (1, 1.5, 3, 6, 12 and 14 mmol/L). As a clinical example, a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) was evaluated. Proton MRS was carried out using a clinical 1.5-T super-conducting magnetic resonance whole-body system. Data were acquired by point resolved spectroscopy. A coupling constant of J = 7.35 Hz (2/7 = 272 ms) and two long in-phase echo time of 272 ms and 544 ms were used to calculate the T2 relaxation time. The tissue water signal was used as an internal standard to quantify lactate. The correlation coefficient R between the calculated lactate concentrations and the known concentration of lactate was 0.99 with a constant factor of 0.32 (1/3.14). In patients with MELAS, the lactate concentration measured by MRS was 6.2 mmol/kg wet weight, which is similar to the value obtained in previous studies. In the present study, we have established a reliable method for lactate quantification in a phantom study and have shown a sample of clinical case of MELAS

  6. Sequential observations of brain edema with proton magnetic resonance imaging and spectroscopy

    International Nuclear Information System (INIS)

    Kamada, Kyousuke

    1996-01-01

    The purpose of this study was to assess the relationship between morphological and metabolic changes in brain edema using proton magnetic resonance systems. The serial changes during the first 24 hours in the cold-injury trauma rat brain model were investigated by proton magnetic resonance imaging ( 1 H MRI) and high-resolution proton MR spectroscopy ( 1 H MRS). We also analyzed the efficacy of AVS 1,2-bis (nicotinamide)-propane which can scavenge free radicals to the edema in this experiment. The edema was developing extensively via the corpus callosum in ipsi- and contralateral hemispheres as shown by gradually increased signal intensity on 1 H MRI. 1 H MRS initially showed accumulation of acetate and lactate, and transient increasing of glutamine. After 24 hours, the increased glutamine decreased below the control, alanine increased, and N-acetyl aspartate decreased with the edema development. AVS-treatment significantly suppressed edema development, increases of lactate and alanine and decreases of N-acetyl aspartate. We suggest that the cold-induced lesion contains anaerobic glycolysis deterioration and results in severe brain tissue breakdown. AVS is proved valuable for the treatment of this edema lesion. Clinical 1 H MRS showed prolonged lactate elevation and significant decreases of other metabolites in human ischemic stroke edema. In peritumoral edema, decreased N-acetyl aspartate gradually improved, and slightly elevated lactate disappeared after tumor removal. 1 H MRS feasibly characterizes the ischemic and peritumoral edema and makes a quantitative analysis in human brain metabolism. We believe the combined 1 H MRI and MRS study is a practical method to monitor the brain conditions and will make it easy and possible to find new therapeutic agents to some brain disorders. (author)

  7. Measurement of the relaxation rate of the magnetization in Mn12O12-acetate using proton NMR echo

    Science.gov (United States)

    Jang; Lascialfari; Borsa; Gatteschi

    2000-03-27

    We present a novel method to measure the relaxation rate W of the magnetization of Mn 12O (12)-acetate (Mn12) magnetic molecular cluster in its S = 10 ground state at low T. It is based on the observation of an exponential growth in time of the proton NMR signal during the thermal equilibration of the magnetization of the molecules. We can explain the novel effect with a simple model which relates the intensity of the proton echo signal to the microscopic reversal of the magnetization of each individual Mn12 molecule during the equilibration process. The method should find wide application in the study of magnetic molecular clusters in off-equilibrium conditions.

  8. Measurement of the Relaxation Rate of the Magnetization in Mn12O12 -Acetate Using Proton NMR Echo

    International Nuclear Information System (INIS)

    Jang, Z. H.; Lascialfari, A.; Borsa, F.; Gatteschi, D.

    2000-01-01

    We present a novel method to measure the relaxation rate W of the magnetization of Mn 12 O 12 -acetate (Mn12) magnetic molecular cluster in its S=10 ground state at low T . It is based on the observation of an exponential growth in time of the proton NMR signal during the thermal equilibration of the magnetization of the molecules. We can explain the novel effect with a simple model which relates the intensity of the proton echo signal to the microscopic reversal of the magnetization of each individual Mn12 molecule during the equilibration process. The method should find wide application in the study of magnetic molecular clusters in off-equilibrium conditions. (c) 2000 The American Physical Society

  9. Recoil momenta distributions in the double photoionization

    International Nuclear Information System (INIS)

    Amusia, M Ya; Liverts, E Z; Drukarev, E G; Mikhai, A I

    2014-01-01

    We calculate the distributions in recoil momenta for the high energy double photoionization of helium caused by quasifree mechanism. The distributions obtain local maxima at small values of the recoil momenta. This agrees with earlier predictions and recent experimental data. Angular correlations which reach the largest value for 'back-to-back' configuration of photoelectrons are also obtained.

  10. Measurements of the ballistic-phonon component resulting from nuclear and electron recoils in crystalline silicon

    International Nuclear Information System (INIS)

    Lee, A.T.; Cabrera, B.; Dougherty, B.L.; Penn, M.J.; Pronko, J.G.; Tamura, S.

    1996-01-01

    We present measurements of the ballistic-phonon component resulting from nuclear and electron recoils in silicon at ∼380 mK. The detectors used for these experiments consist of a 300-μm-thick monocrystal of silicon instrumented with superconducting titanium transition-edge sensors. These sensors detect the initial wavefront of athermal phonons and give a pulse height that is sensitive to changes in surface-energy density resulting from the focusing of ballistic phonons. Nuclear recoils were generated by neutron bombardment of the detector. A Van de Graaff proton accelerator and a thick 7 Li target were used. Pulse-height spectra were compared for neutron, x-ray, and γ-ray events. A previous analysis of this data set found evidence for an increase in the ballistic-phonon component for nuclear recoils compared to electron recoils at a 95% confidence level. An improved understanding of the detector response has led to a change in the result. In the present analysis, the data are consistent with no increase at the 68% confidence level. This change stems from an increase in the uncertainty of the result rather than a significant change in the central value. The increase in ballistic phonon energy for nuclear recoils compared to electron recoils as a fraction of the total phonon energy (for equal total phonon energy events) was found to be 0.024 +0.041 -0.055 (68% confidence level). This result sets a limit of 11.6% (95% confidence level) on the ballistic phonon enhancement for nuclear recoils predicted by open-quote open-quote hot spot close-quote close-quote and electron-hole droplet models, which is the most stringent to date. To measure the ballistic-phonon component resulting from electron recoils, the pulse height as a function of event depth was compared to that of phonon simulations. (Abstract Truncated)

  11. SU-F-T-211: Evaluation of a Dual Focusing Magnet System for the Treatment of Small Proton Targets

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, TT; McAuley, GA; Heczko, S; Slater, J [Loma Linda University, Loma Linda, CA (United States); Wroe, A [Loma Linda University, Loma Linda, CA (United States); Loma Linda University Medical Center, Loma Linda, CA (United States)

    2016-06-15

    Purpose: To investigate magnetic focusing for small volume proton targets using a doublet combination of quadrupole rare earth permanent magnet Halbach cylinder assemblies Methods: Monte Carlo computer simulations were performed using the Geant4 toolkit to compare dose depositions of proton beams transported through two focusing magnets or in their absence. Proton beams with energies of 127 MeV and initial diameters of 5, 8 and 10 mm were delivered through two identical focusing magnets similar to those currently in experimental use at Loma Linda University Medical Center. Analogous experiments used optimized configurations based on the simulation results. Dose was measured by a diode detector and Gafchromic EBT3 film and compared to simulation data. Based on results from the experimental data, an additional set of simulations was performed with an initial beam diameter of 18 mm and a two differing length magnets (40mm & 68mm). Results: Experimental data matched well with Monte Carlo simulations. However, under conditions necessary to produce circular beam spots at target depth, magnetically focused beams using two identical 40 mm length magnets did not meet all of our performance criteria of circular beam spots, improved peak to entrance (P/E) dose ratios and dose delivery efficiencies. The simulations using the longer 68 mm 2nd magnet yielded better results with 34% better P/E dose ratio and 20–50% better dose delivery efficiencies when compared to unfocused 10 mm beams. Conclusion: While magnetic focusing using two magnets with identical focusing power did not yield desired results, ongoing Monte Carlo simulations suggest that increasing the length of the 2nd magnet to 68 mm could improve P/E dose ratios and dose efficiencies. Future work includes additional experimental validation of the longer 2nd magnet setup as well as experiments with triplet magnet systems. This project was sponsored with funding from the Department of Defense (DOD# W81XWH-BAA-10-1).

  12. Lifetime measurements using the recoil distance method - achievements and perspectives

    International Nuclear Information System (INIS)

    Kruecken, R.

    2001-01-01

    The recoil distance method (RDM) for measuring pico-second nuclear level lifetimes and its use in nuclear structure studies is reviewed and perspectives for the future are presented. High precision measurements in the mass-130 region, studies of multi-phonon states in rare earth nuclei, the investigation of shape coexistence and the recently discovered phenomenon of 'magnetic rotation' are reviewed. Prospects for lifetime measurements in exotic regions of nuclei such as the measurement of lifetimes in neutron rich nuclei populated via spontaneous and heavy-ion induced fission are discussed. Other prospects include the use of the RDM technique in conjunction with recoil separators. The relevance of these techniques for experiments with radioactive ion beams will be discussed

  13. Tests of prototype magnets and study on a MCP based proton detector for the neutron lifetime experiment PENeLOPE

    International Nuclear Information System (INIS)

    Materne, Stefan

    2013-01-01

    The precision experiment PENeLOPE will store ultra-cold neutrons in a magnetic trap and determine the neutron lifetime via the time-resolved counting of the decay-protons. The thesis reports on training and performance tests of prototypes of the superconducting coils. Additionally, a magnetic field mapper for PENeLOPE was characterized. In the second part of the thesis, microchannel plates (MCPs) were studied with alpha particles and protons as a possible candidate for the decay particle detector in PENeLOPE.

  14. Effect of the energy of recoil atoms on conductivity compensation in moderately doped n-Si and n-SiC under irradiation with MeV electrons and protons

    Energy Technology Data Exchange (ETDEWEB)

    Kozlovski, V.V. [St. Petersburg State Polytechnic University, St. Petersburg 195251 (Russian Federation); Lebedev, A.A., E-mail: shura.lebe@mail.ioffe.ru [Ioffe Physical Technical Institute, Russian Academy of Sciences, St. Petersburg 194021 (Russian Federation); National Research University of Information Technologies, Mechanics, and Optics, St. Petersburg 197101 (Russian Federation); Emtsev, V.V.; Oganesyan, G.A. [Ioffe Physical Technical Institute, Russian Academy of Sciences, St. Petersburg 194021 (Russian Federation)

    2016-10-01

    Processes of radiation defect formation and conductivity compensation in silicon and silicon carbide irradiated with 0.9 MeV electrons are considered in comparison with the electron irradiation at higher energies. The experimental values of the carrier removal rate at the electron energy of 0.9 MeV are nearly an order of magnitude smaller than the similar values of the parameter for higher energy electrons (6–9 MeV). At the same time, the formation cross-section of primary radiation defects (Frenkel pairs, FPs) is nearly energy-independent in this range. It is assumed that these differences are due to the influence exerted by the energy of primary knocked-on atoms (PKAs). As the PKA energy increases, the average distance between the genetically related FPs grows and, as a consequence, the fraction of FPs unrecombined under irradiation becomes larger. The FP recombination radius is estimated (∼1.1 nm), which makes it possible to ascertain the charge state of the recombining components. Second, the increase in the PKA energy enables formation of new, more complex secondary radiation defects. At electron energies exceeding 15 MeV, the average PKA energies are closer to the values obtained under irradiation with 1 MeV protons, compared with an electron irradiation at the same energy. As for the radiation-induced defect formation, the irradiation of silicon with MeV protons can be, in principle, regarded as a superposition of the irradiation with 1 MeV electrons and that with silicon ions having energy of ∼1 keV, with the “source” of silicon ions generating these ions uniformly across the sample thickness.

  15. Implantation, recoil implantation, and sputtering

    International Nuclear Information System (INIS)

    Kelly, R.

    1984-01-01

    Underlying ion-beam modification of surfaces is the more basic subject of particle-surface interaction. The ideas can be grouped into forward and backward features, i.e. those affecting the interior of the target and those leading to particle expulsion. Forward effects include the stopping of the incident particles and the deposition of energy, both governed by integral equations which are easily set up but difficult to solve. Closely related is recoil implantation where emphasis is placed not on the stopping of the incident particles but on their interaction with target atoms with resulting implantation of these atoms. Backward effects, all of which are denoted as sputtering, are in general either of collisional, thermal, electronic, or exfoliational origin. (Auth.)

  16. Recoil-ion momentum spectroscopy

    International Nuclear Information System (INIS)

    Ullrich, J.; Moshammer, R.; Doerner, R.; Jagutzki, O.; Mergel, V.; Schmidt-Boecking, H.; Spielberger, L.

    1996-10-01

    High-resolution recoil-ion momentum spectroscopy (RIMS) is a novel technique to determine the charge state and the complete final momentum vector P R of a recoiling target ion emerging from an ionising collision of an atom with any kind of radiation. It offers a unique combination of superior momentum resolution in all three spatial directions of ΔP R = 0.07 a.u. with a large detection solid angle of ΔΩ R /4π≥ 98%. Recently, low-energy electron analysers based on rigorously new concepts and reaching similar specifications were successfully integrated into RIM spectrometers yielding so-called ''reaction microscopes''. Exploiting these techniques, a large variety of atomic reactions for ion, electron, photon and antiproton impact have been explored in unprecedented detail and completeness. Among them first kinematically complete experiments on electron capture, single and double ionisation in ion-atom collisions at projectile energies between 5 keV and 1.4 GeV. Double photoionisation of He has been investigated at energies E γ close to the threshold (E γ = 80 eV) up to E γ = 58 keV. At E γ >8 keV the contributions to double ionisation after photoabsorption and Compton scattering were kinematically separated for the first time. These and many other results will be reviewed in this article. In addition, the experimental technique is described in some detail and emphasis is given to envisage the rich future potential of the method in various fields of atomic collision physics with atoms, molecules and clusters. (orig.)

  17. Search for magnetic monopoles with the MoEDAL prototype trapping detector in 8 TeV proton-proton collisions at the LHC

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    The MoEDAL experiment is designed to search for magnetic monopoles and other highly-ionising particles produced in high-energy collisions at the LHC. The largely passive MoEDAL detector, deployed at Interaction Point 8 on the LHC ring, relies on two dedicated direct detection techniques. The first technique is based on stacks of nuclear-track detectors with surface area ∼18 m2, sensitive to particle ionisation exceeding a high threshold. These detectors are analysed offline by optical scanning microscopes. The second technique is based on the trapping of charged particles in an array of roughly 800 kg of aluminium samples. These samples are monitored offline for the presence of trapped magnetic charge at a remote superconducting magnetometer facility. We present here the results of a search for magnetic monopoles using a 160 kg prototype MoEDAL trapping detector exposed to 8 TeV proton-proton collisions at the LHC, for an integrated luminosity of 0.75 fb−1. No magnetic charge exceeding 0.5gD (where gD is ...

  18. Search for magnetic monopoles with the MoEDAL prototype trapping detector in 8 TeV proton-proton collisions at the LHC

    CERN Document Server

    Acharya, B.

    2016-08-10

    The MoEDAL experiment is designed to search for magnetic monopoles and other highly-ionising particles produced in high-energy collisions at the LHC. The largely passive MoEDAL detector, deployed at Interaction Point 8 on the LHC ring, relies on two dedicated direct detection techniques. The first technique is based on stacks of nuclear-track detectors with surface area $\\sim$18 m$^2$, sensitive to particle ionisation exceeding a high threshold. These detectors are analysed offline by optical scanning microscopes. The second technique is based on the trapping of charged particles in an array of roughly 800 kg of aluminium samples. These samples are monitored offline for the presence of trapped magnetic charge at a remote superconducting magnetometer facility. We present here the results of a search for magnetic monopoles using a 160 kg prototype MoEDAL trapping detector exposed to 8 TeV proton-proton collisions at the LHC, for an integrated luminosity of 0.75 fb$^{-1}$. No magnetic charge exceeding $0.5g_{\\rm...

  19. Clinical perspectives of hybrid proton-fluorine magnetic resonance imaging and spectroscopy.

    Science.gov (United States)

    Wolters, Martijn; Mohades, Seyede G; Hackeng, Tilman M; Post, Mark J; Kooi, Marianne E; Backes, Walter H

    2013-05-01

    The number of applications of fluorine 19 (19F) magnetic resonance (MR) imaging and spectroscopy in biomedical and clinical research is steadily growing. The 100% natural abundance of fluorine and its relatively high sensitivity for MR (83% to that of protons) make it an interesting nucleus for a wide range of MR applications. Fluorinated contrast media have a number of advantages over the conventionally used gadolinium-based or iron-based contrast agents. The absence of an endogenous fluorine background intensity in the human body facilitates reliable quantification of fluorinated contrast medium or drugs. Anatomy can be visualized separately with proton MR imaging, creating the application of hybrid hydrogen 1 (1H)/19F MR imaging. The availability of 2 channels (ie, the 1H and 19F channels) enables dual-targeted molecular imaging. Recently, novel developments have emerged on fluorine-based contrast media in preclinical studies and imaging techniques. The developments in fluorine MR seem promising for clinical applications, with contributions in therapy monitoring, assessment of lung function, angiography, and molecular imaging. This review outlines the translation from recent advances in preclinical MR imaging and spectroscopy to future perspectives of clinical hybrid 1H/19/F MR imaging applications.

  20. Spin flipping a stored polarized proton beam with an rf magnetic field

    International Nuclear Information System (INIS)

    Hu, S.Q.; Blinov, B.B.; Caussyn, D.D.

    1995-01-01

    The authors studied the spin flipping of a vertically polarized, stored 139 MeV proton beam with an rf solenoid magnetic field. By sweeping the rf frequency through an rf depolarizing resonance, they made the spin flip. The spin flipping was more efficient for slower ramp times, and the spin flip efficiency peaked at some optimum ramp time that is not yet fully understood. Since frequent spin flipping could significantly reduce the systematic errors in scattering experiments using a stored polarized beam, it is very important to minimize the depolarization after each spin flip. In this experiment, with multiple spin flips, the authors found a polarization loss of 0.0000 ± 0.0005 per spin flip under the best conditions; this loss increased significantly for small changes in the conditions

  1. Proton magnetic resonance spectroscopy reflects metabolic decompensation in maple syrup urine disease

    Energy Technology Data Exchange (ETDEWEB)

    Heindel, W. [Dept. of Diagnostic Radiology, Univ. Koeln (Germany); Kugel, H. [Dept. of Diagnostic Radiology, Univ. Koeln (Germany); Wendel, U. [Children`s Hospital, Univ. Duesseldorf (Germany); Roth, B. [Children`s Hospital, Univ. Koeln (Germany); Benz-Bohm, G. [Dept. of Diagnostic Radiology, Univ. Koeln (Germany)

    1995-06-01

    Using localized proton magnetic resonance spectroscopy ({sup 1}H-MRS), accumulation of branchedchain amino acids (BCAA) and their corresponding 2-oxo acids (BCOA) could be non-invasively demonstrated in the brain of a 9-year-old girl suffering from classical maple syrup urine disease. During acute metabolic decompensation, the compounds caused a signal at a chemical shift of 0.9 ppm which was assigned by in vitro experiments. The brain tissue concentration of the sum of BCAA and BCOA could be estimated as 0.9 mmol/l. Localized {sup 1}H-MRS of the brain appears to be suitable for examining patients suffering from maple syrup urine disease in different metabolic states. (orig.)

  2. Quantification of brain metabolites in amyotrophic lateral sclerosis by localized proton magnetic resonance spectroscopy

    DEFF Research Database (Denmark)

    Gredal, O; Rosenbaum, S; Topp, S

    1997-01-01

    We performed proton magnetic resonance spectroscopy (1H-MRS) in patients with motor neuron disease (MND) to determine the absolute in vivo concentrations in the brain of the metabolites N-acetyl aspartate (NAA), choline (Cho), and creatine (Cr/PCr). We examined the spectra acquired from a 20 x 20 x...... subjects. We estimated the concentrations of the metabolites using the water signal as an internal standard. The concentrations of Cho and Cr/PCr in both brain regions, as well as the concentration of NAA in the cerebellum, were unaltered in the MND patients compared with the controls. Only MND patients...... with both upper and lower motor neuron signs had a significantly decreased concentration of NAA (9.13 +/- 0.28 mM, mean +/- SEM) in the primary motor cortex when compared with healthy controls (10.03 +/- 0.22 mM). In conclusion, the slightly decreased concentration of NAA in the primary motor cortex from...

  3. Second law analysis of the helium refrigerators for the HERA proton magnet ring

    International Nuclear Information System (INIS)

    Ziegler, B.O.

    1986-01-01

    Each of the three refrigerators for the HERA proton magnet ring must provide 6.775 kW of refrigeration at 4.3 0 K plus 20.5 g/s of helium at 2.5 bar and 4.5 0 K for leads cooling and 20 kW of refrigeration at 40-80 0 K for shield cooling. The capital cost of large refrigerators is small compared with operating costs. Therefore the refrigeration process was analysed on the basis of exergy. This means the irreversibility of each component is expressed as power input into the plant. The process realised consists of the turbine cycle, divided into two streams with 5 gas bearing turbines all together, and the Joule Thomson cycle. Special attention was paid to the cold end of the plant. The optimization resulted in a new configuration with two turboexpanders running in parallel on different temperature levels

  4. Cerebral metabolic abnormalities in congestive heart failure detected by proton magnetic resonance spectroscopy.

    Science.gov (United States)

    Lee, C W; Lee, J H; Kim, J J; Park, S W; Hong, M K; Kim, S T; Lim, T H; Park, S J

    1999-04-01

    Using proton magnetic resonance spectroscopy, we investigated cerebral metabolism and its determinants in congestive heart failure (CHF), and the effects of cardiac transplantation on these measurements. Few data are available about cerebral metabolism in CHF. Fifty patients with CHF (ejection fraction OGM) and parietal white matter (PWM). Absolute levels of the metabolites (N-acetylaspartate, creatine, choline, myo-inositol) were calculated. In PWM only creatine level was significantly lower in CHF than in control subjects, but in OGM all four metabolite levels were decreased in CHF. The creatine level was independently correlated with half-recovery time and duration of heart failure symptoms in PWM (r = -0.56, p OGM (r = 0.58, p < 0.05). Cerebral metabolic abnormalities were improved after successful cardiac transplantation. This study shows that cerebral metabolism is abnormally deranged in advanced CHF and it may serve as a potential marker of the disease severity.

  5. Proton magnetic resonance spectroscopy reflects metabolic decompensation in maple syrup urine disease

    International Nuclear Information System (INIS)

    Heindel, W.; Kugel, H.; Wendel, U.; Roth, B.; Benz-Bohm, G.

    1995-01-01

    Using localized proton magnetic resonance spectroscopy ( 1 H-MRS), accumulation of branchedchain amino acids (BCAA) and their corresponding 2-oxo acids (BCOA) could be non-invasively demonstrated in the brain of a 9-year-old girl suffering from classical maple syrup urine disease. During acute metabolic decompensation, the compounds caused a signal at a chemical shift of 0.9 ppm which was assigned by in vitro experiments. The brain tissue concentration of the sum of BCAA and BCOA could be estimated as 0.9 mmol/l. Localized 1 H-MRS of the brain appears to be suitable for examining patients suffering from maple syrup urine disease in different metabolic states. (orig.)

  6. Gas powered fluid gun with recoil mitigation

    Science.gov (United States)

    Grubelich, Mark C; Yonas, Gerold

    2013-11-12

    A gas powered fluid gun for propelling a stream or slug of a fluid at high velocity toward a target. Recoil mitigation is provided that reduces or eliminates the associated recoil forces, with minimal or no backwash. By launching a quantity of water in the opposite direction, net momentum forces are reduced or eliminated. Examples of recoil mitigation devices include a cone for making a conical fluid sheet, a device forming multiple impinging streams of fluid, a cavitating venturi, one or more spinning vanes, or an annular tangential entry/exit.

  7. Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder

    Science.gov (United States)

    Corrigan, Neva M.; Shaw, Dennis. W. W.; Richards, Todd L.; Estes, Annette M.; Friedman, Seth D.; Petropoulos, Helen; Artru, Alan A.; Dager, Stephen R.

    2012-01-01

    Brain mitochondrial dysfunction has been proposed as an etiologic factor in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopic imaging ([superscript 1]HMRS) and MRI were used to assess for evidence of brain mitochondrial dysfunction in longitudinal samples of children with ASD or developmental delay (DD), and cross-sectionally…

  8. Accurate classification of brain gliomas by discriminate dictionary learning based on projective dictionary pair learning of proton magnetic resonance spectra.

    Science.gov (United States)

    Adebileje, Sikiru Afolabi; Ghasemi, Keyvan; Aiyelabegan, Hammed Tanimowo; Saligheh Rad, Hamidreza

    2017-04-01

    Proton magnetic resonance spectroscopy is a powerful noninvasive technique that complements the structural images of cMRI, which aids biomedical and clinical researches, by identifying and visualizing the compositions of various metabolites within the tissues of interest. However, accurate classification of proton magnetic resonance spectroscopy is still a challenging issue in clinics due to low signal-to-noise ratio, overlapping peaks of metabolites, and the presence of background macromolecules. This paper evaluates the performance of a discriminate dictionary learning classifiers based on projective dictionary pair learning method for brain gliomas proton magnetic resonance spectroscopy spectra classification task, and the result were compared with the sub-dictionary learning methods. The proton magnetic resonance spectroscopy data contain a total of 150 spectra (74 healthy, 23 grade II, 23 grade III, and 30 grade IV) from two databases. The datasets from both databases were first coupled together, followed by column normalization. The Kennard-Stone algorithm was used to split the datasets into its training and test sets. Performance comparison based on the overall accuracy, sensitivity, specificity, and precision was conducted. Based on the overall accuracy of our classification scheme, the dictionary pair learning method was found to outperform the sub-dictionary learning methods 97.78% compared with 68.89%, respectively. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  9. Three-dimensional proton magnetic resonance spectroscopic imaging with and without an endorectal coil: a prostate phantom study

    NARCIS (Netherlands)

    Ma, C.; Chen, L.; Scheenen, T.W.J.; Lu, J.; Wang, J

    2015-01-01

    Proton magnetic resonance spectroscopic imaging (MRSI) of the prostate has been used with only a combination of external surface coils. The quality of spectral fitting of the (choline + creatine)/citrate ([Cho + Cr]/Cit) ratio at different field strengths and different coils is important for

  10. [Possibilities in the differential diagnosis of brain neoplasms using the long and short time sequences of proton magnetic resonance spectroscopy

    NARCIS (Netherlands)

    Gajewicz, W.; Goraj, B.M.

    2004-01-01

    Currently to perform proton magnetic resonance spectroscopy (1H MRS) with single voxel spectroscopy (SVS) technique long and/or short echo time sequences are used in order to provide complementary information. PURPOSE: The aim of the study was to compare the usefulness of STEAM (time echo, TE, 20

  11. N-acetylated metabolites in urine: proton nuclear magnetic resonance spectroscopic study on patients with inborn errors of metabolism.

    NARCIS (Netherlands)

    Engelke, U.F.H.; Liebrand-van Sambeek, M.L.F.; Jong, J.G.N. de; Leroy, J.G.; Morava, E.; Smeitink, J.A.M.; Wevers, R.A.

    2004-01-01

    BACKGROUND: There is no comprehensive analytical technique to analyze N-acetylated metabolites in urine. Many of these compounds are involved in inborn errors of metabolism. In the present study, we examined the potential of proton nuclear magnetic resonance ((1)H-NMR) spectroscopy as a tool to

  12. Correction magnetic field in electromagnet of proton accelerator using CST software; Correcao do campo magnetico em um eletroima de um acelerador de protons usando o software CST

    Energy Technology Data Exchange (ETDEWEB)

    Rabelo, L.A.; Campos, T.P.R., E-mail: luisarabelo88@gmail.com [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte (Brazil). Dept. de Engenharia Nuclear

    2016-07-01

    The aim of this paper is to present the study and simulation of uniform magnetic field electromagnets new circular accelerator model for protons with energy range between 15 MeV and 64 MeV. In addition, investigating materials and the changes induced by the presence of 'gaps' synchronism correction. The electromagnet simulations, predefined, were made in electromagnetic field simulation software CST EM Studio® 3D 2015. The results showed an even distribution of the magnetic field in the compact electromagnet with the same homogenization structures. The results showed regular distribution of the magnetic field in the compact electromagnet with homogenization structures. In conclusion, the electromagnetic model proposed shown to be feasible for a circular accelerator and comply the synchronization requirements. (author)

  13. Cosmic ray-induced spallation recoil tracks in meteoritic phosphates: simulation at the CERN synchrocyclotron

    Energy Technology Data Exchange (ETDEWEB)

    Perron, C [Centre National de la Recherche Scientifique (CNRS), 75 - Paris (France). Inst. d` Astrophysique; [Museum National d` Histoire Naturelle, 75 - Paris (France)

    1994-12-31

    Annealed meteoritic phosphate crystals have been irradiated by 600 MeV protons to simulate cosmic ray irradiation in space. Spallation recoil tracks were then revealed, which mimic fission tracks, specially when observed in the SEM. A production yield of 9.3 {+-} 2.2 x 10{sup 8} spallation track per proton has been obtained for merrillite, and a substantially lower value (2.5 per proton) for apatite. A nominal production yield in space of 6 tracks per year has been derived, which may be used for a rough estimate of spallation track densities in chondritic merrillite. (Author).

  14. Proton nuclear magnetic resonance and spectrophotometric studies of nickel(II)-iron(II) hybrid hemoglobins

    International Nuclear Information System (INIS)

    Shibayama, N.; Inubushi, T.; Morimoto, H.; Yonetani, T.

    1987-01-01

    Ni(II)-Fe(II) hybrid hemoglobins, α(Fe) 2 β(Ni) 2 and α(Ni) 2 β(Fe) 2 , have been characterized by proton nuclear magnetic resonance with Ni(II) protoporphyrin IX (Ni-PP) incorporated in apoprotein, which serves as a permanent deoxyheme. α(Fe) 2 β(Ni) 2 , α(Ni) 2 β(Fe) 2 , and NiHb commonly show exchangeable proton resonances at 11 and 14 ppm, due to hydrogen-bonded protons in a deoxy-like structure. Upon binding of carbon monoxide (CO) to α(Fe) 2 β(Ni) 2 , these resonances disappear at pH 6.5 to pH 8.5. On the other hand, the complementary hybrid α(Ni) 2 β(Fe-CO) 2 showed the 11 and 14 ppm resonances at low pH. Upon raising pH, the intensities of both resonances are reduced, although these changes are not synchronized. Electronic absorption spectra and hyperfine-shifted proton resonances indicate that the ligation of CO in the β(Fe) subunits induced changes in the coordination and spin states of Ni-PP in the α subunits. In a deoxy-like structure, the coordination of Ni-PP in the α subunits is predominantly in a low-spin (S = 0) four-coordination state, whereas in an oxy-like structure the contribution of a high-spin (S = 1) five-coordination state markedly increased. Ni-PP in the β subunits always takes a high-spin five-coordination state regardless of solution conditions and the state of ligation in the partner α(Fe) subunits. In the β(Ni) subunits, a significant downfield shift of the proximal histidyl N/sub δ/H resonance and a change in the absorption spectrum of Ni-PP were detected, upon changing the quaternary structure of the hybrid. The chemical shifts were analyzed in terms of the E11-Val methyls vs. the porphyrin rings in hybrid Hbs

  15. An improved permanent magnet quadrupole design with larger good field region for high intensity proton linacs

    Energy Technology Data Exchange (ETDEWEB)

    Mathew, Jose V., E-mail: josev.mathew@gmail.com; Rao, S.V.L.S.; Krishnagopal, S.; Singh, P.

    2013-11-01

    The Low Energy High Intensity Proton Accelerator (LEHIPA), being developed at the Bhabha Atomic Research Centre (BARC) will produce a 20 MeV, 30 mA, continuous wave (CW) proton beam. At these low velocities, space-charge forces dominate, and could lead to larger beam sizes and beam halos. Hence in the design of the focusing lattice of the LEHIPA drift tube linac (DTL) using permanent magnet quadrupoles (PMQs), a larger good field region is preferred. Here we study, using the two dimensional (2D) and three dimensional (3D) simulation codes PANDIRA and RADIA, four different types of cylindrical PMQ designs: 16-segment trapezoidal Halbach configuration, bullet-nosed geometry and 8- and 16-segment rectangular geometries. The trapezoidal Halbach geometry is used in a variety of accelerators since it provides very high field gradients in small bores, while the bullet-nosed geometry, which is a combination of the trapezoidal and rectangular designs, is used in some DTLs. This study shows that a larger good field region is possible in the 16-segment rectangular design as compared to the Halbach and bullet-nosed designs, making it more attractive for high-intensity proton linacs. An improvement in good-field region by ∼16% over the Halbach design is obtained in the optimized 16-segment rectangular design, although the field gradient is lower by ∼20%. Tolerance studies show that the rectangular segment PMQ design is substantially less sensitive to the easy axis orientation errors and hence will be a better choice for DTLs. -- Highlights: • An improved permanent magnet quadrupole (PMQ) design with larger good field region is proposed. • We investigate four PMQ designs, including the widely used Halbach and bullet nosed designs. • Analytical calculations are backed by 2D as well as 3D numerical solvers, PANDIRA and RADIA. • The optimized 16 segment rectangular PMQ design is identified to exhibit the largest good field region. • The effect of easy axis orientation

  16. An improved permanent magnet quadrupole design with larger good field region for high intensity proton linacs

    International Nuclear Information System (INIS)

    Mathew, Jose V.; Rao, S.V.L.S.; Krishnagopal, S.; Singh, P.

    2013-01-01

    The Low Energy High Intensity Proton Accelerator (LEHIPA), being developed at the Bhabha Atomic Research Centre (BARC) will produce a 20 MeV, 30 mA, continuous wave (CW) proton beam. At these low velocities, space-charge forces dominate, and could lead to larger beam sizes and beam halos. Hence in the design of the focusing lattice of the LEHIPA drift tube linac (DTL) using permanent magnet quadrupoles (PMQs), a larger good field region is preferred. Here we study, using the two dimensional (2D) and three dimensional (3D) simulation codes PANDIRA and RADIA, four different types of cylindrical PMQ designs: 16-segment trapezoidal Halbach configuration, bullet-nosed geometry and 8- and 16-segment rectangular geometries. The trapezoidal Halbach geometry is used in a variety of accelerators since it provides very high field gradients in small bores, while the bullet-nosed geometry, which is a combination of the trapezoidal and rectangular designs, is used in some DTLs. This study shows that a larger good field region is possible in the 16-segment rectangular design as compared to the Halbach and bullet-nosed designs, making it more attractive for high-intensity proton linacs. An improvement in good-field region by ∼16% over the Halbach design is obtained in the optimized 16-segment rectangular design, although the field gradient is lower by ∼20%. Tolerance studies show that the rectangular segment PMQ design is substantially less sensitive to the easy axis orientation errors and hence will be a better choice for DTLs. -- Highlights: • An improved permanent magnet quadrupole (PMQ) design with larger good field region is proposed. • We investigate four PMQ designs, including the widely used Halbach and bullet nosed designs. • Analytical calculations are backed by 2D as well as 3D numerical solvers, PANDIRA and RADIA. • The optimized 16 segment rectangular PMQ design is identified to exhibit the largest good field region. • The effect of easy axis orientation

  17. On recoil energy dependent void swelling in pure copper: Theoretical treatment

    International Nuclear Information System (INIS)

    Golubov, S.I.; Singh, B.N.; Trinkaus, H.

    2000-06-01

    Over the years, an enormous amount of experimental results have been reported on damage accumulation (e.g. void swelling) in metals and alloys irradiated under vastly different recoil energy conditions. Unfortunately, however, very little is known either experimentally or theoretically about the effect of recoil energy on damage accumulation. Recently, dedicated irradiation experiments using 2.5 MeV electrons, 3.0 MeV protons and fission neutrons have been carried out to determine the effect of recoil energy on the damage accumulation behaviour in pure copper and the results have been reported in Part I of this paper (Singh, Eldrup, Horsewell, Ehrhart and Dworschak 2000). The present paper attempts to provide a theoretical framework within which the effect of recoil energy on damage accumulation behaviour can be understood. The damage accumulation under Frenkel pair production (e.g. 2.5 MeV electron) has been treated in terms of the standard rate theory (SRT) model whereas the evolution of the defect microstructure under cascade damage conditions (e.g. 3.0 MeV protons and fission neutrons) has been calculated within the framework of the production bias model (PBM). Theoretical results, in agreement with experimental results, show that the damage accumulation behaviour is very sensitive to recoil energy and under cascade damage conditions can be treated only within the framework of the PBM. The intracascade clustering of self-interstitial atoms (SIAs) and the properties of SIA clusters such as one-dimensional diffusional transport and thermal stability are found to be the main reasons for the recoil energy dependent vacancy supersaturation. The vacancy supersaturation is the main driving force for the void nucleation and void swelling. In the case of Frenkel pair production, the experimental results are found to be consistent with the SRT model with a dislocation bias value of 2 %. (au)

  18. Sonic Rarefaction Wave Low Recoil Gun

    National Research Council Canada - National Science Library

    Kathe, E

    2002-01-01

    A principal challenge faced by the U.S. Army TACOM-ARDEC Benet Laboratories in the design of armaments for lightweight future fighting vehicles with lethality overmatch is mitigating the deleterious effects of large caliber cannon recoil...

  19. Search for Magnetic Monopoles with the MoEDAL Forward Trapping Detector in 13 TeV Proton-Proton Collisions at the LHC

    Science.gov (United States)

    Acharya, B.; Alexandre, J.; Baines, S.; Benes, P.; Bergmann, B.; Bernabéu, J.; Branzas, H.; Campbell, M.; Caramete, L.; Cecchini, S.; de Montigny, M.; De Roeck, A.; Ellis, J. R.; Fairbairn, M.; Felea, D.; Flores, J.; Frank, M.; Frekers, D.; Garcia, C.; Hirt, A. M.; Janecek, J.; Kalliokoski, M.; Katre, A.; Kim, D.-W.; Kinoshita, K.; Korzenev, A.; Lacarrère, D. H.; Lee, S. C.; Leroy, C.; Lionti, A.; Mamuzic, J.; Margiotta, A.; Mauri, N.; Mavromatos, N. E.; Mermod, P.; Mitsou, V. A.; Orava, R.; Parker, B.; Pasqualini, L.; Patrizii, L.; Pǎvǎlaş, G. E.; Pinfold, J. L.; Popa, V.; Pozzato, M.; Pospisil, S.; Rajantie, A.; Ruiz de Austri, R.; Sahnoun, Z.; Sakellariadou, M.; Sarkar, S.; Semenoff, G.; Shaa, A.; Sirri, G.; Sliwa, K.; Soluk, R.; Spurio, M.; Srivastava, Y. N.; Suk, M.; Swain, J.; Tenti, M.; Togo, V.; Tuszyński, J. A.; Vento, V.; Vives, O.; Vykydal, Z.; Whyntie, T.; Widom, A.; Willems, G.; Yoon, J. H.; Zgura, I. S.; MoEDAL Collaboration

    2017-02-01

    MoEDAL is designed to identify new physics in the form of long-lived highly ionizing particles produced in high-energy LHC collisions. Its arrays of plastic nuclear-track detectors and aluminium trapping volumes provide two independent passive detection techniques. We present here the results of a first search for magnetic monopole production in 13 TeV proton-proton collisions using the trapping technique, extending a previous publication with 8 TeV data during LHC Run 1. A total of 222 kg of MoEDAL trapping detector samples was exposed in the forward region and analyzed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges exceeding half the Dirac charge are excluded in all samples and limits are placed for the first time on the production of magnetic monopoles in 13 TeV p p collisions. The search probes mass ranges previously inaccessible to collider experiments for up to five times the Dirac charge.

  20. Search for Magnetic Monopoles with the MoEDAL Forward Trapping Detector in 13 TeV Proton-Proton Collisions at the LHC.

    Science.gov (United States)

    Acharya, B; Alexandre, J; Baines, S; Benes, P; Bergmann, B; Bernabéu, J; Branzas, H; Campbell, M; Caramete, L; Cecchini, S; de Montigny, M; De Roeck, A; Ellis, J R; Fairbairn, M; Felea, D; Flores, J; Frank, M; Frekers, D; Garcia, C; Hirt, A M; Janecek, J; Kalliokoski, M; Katre, A; Kim, D-W; Kinoshita, K; Korzenev, A; Lacarrère, D H; Lee, S C; Leroy, C; Lionti, A; Mamuzic, J; Margiotta, A; Mauri, N; Mavromatos, N E; Mermod, P; Mitsou, V A; Orava, R; Parker, B; Pasqualini, L; Patrizii, L; Păvălaş, G E; Pinfold, J L; Popa, V; Pozzato, M; Pospisil, S; Rajantie, A; Ruiz de Austri, R; Sahnoun, Z; Sakellariadou, M; Sarkar, S; Semenoff, G; Shaa, A; Sirri, G; Sliwa, K; Soluk, R; Spurio, M; Srivastava, Y N; Suk, M; Swain, J; Tenti, M; Togo, V; Tuszyński, J A; Vento, V; Vives, O; Vykydal, Z; Whyntie, T; Widom, A; Willems, G; Yoon, J H; Zgura, I S

    2017-02-10

    MoEDAL is designed to identify new physics in the form of long-lived highly ionizing particles produced in high-energy LHC collisions. Its arrays of plastic nuclear-track detectors and aluminium trapping volumes provide two independent passive detection techniques. We present here the results of a first search for magnetic monopole production in 13 TeV proton-proton collisions using the trapping technique, extending a previous publication with 8 TeV data during LHC Run 1. A total of 222 kg of MoEDAL trapping detector samples was exposed in the forward region and analyzed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges exceeding half the Dirac charge are excluded in all samples and limits are placed for the first time on the production of magnetic monopoles in 13 TeV pp collisions. The search probes mass ranges previously inaccessible to collider experiments for up to five times the Dirac charge.

  1. Search for magnetic monopoles with the MoEDAL forward trapping detector in 13 TeV proton-proton collisions at the LHC

    CERN Document Server

    Acharya, B.; Baines, S.; Benes, P.; Bergmann, B.; Bernabéu, J.; Branzas, H.; Campbell, M.; Caramete, L.; Cecchini, S.; de Montigny, M.; De Roeck, A.; Ellis, J.R.; Fairbairn, M.; Felea, D.; Flores, J.; Frank, M.; Frekers, D.; Garcia, C.; Hirt, A.M.; Janecek, J.; Kalliokoski, M.; Katre, A.; Kim, D.-W.; Kinoshita, K.; Korzenev, A.; Lacarrère, D.H.; Lee, S.C.; Leroy, C.; Lionti, A.; Mamuzic, J.; Margiotta, A.; Mauri, N.; Mavromatos, N.E.; Mermod, P.; Mitsou, V.A.; Orava, R.; Parker, B.; Pasqualini, L.; Patrizii, L.; Păvălaş, G.E.; Pinfold, J.L.; Popa, V.; Pozzato, M.; Pospisil, S.; Rajantie, A.; Ruiz de Austri, R.; Sahnoun, Z.; Sakellariadou, M.; Sarkar, S.; Semenoff, G.; Shaa, A.; Sirri, G.; Sliwa, K.; Soluk, R.; Spurio, M.; Srivastava, Y.N.; Suk, M.; Swain, J.; Tenti, M.; Togo, V.; Tuszyński, J.A.; Vento, V.; Vives, O.; Vykydal, Z.; Whyntie, T.; Widom, A.; Willems, G.; Yoon, J.H.; Zgura, I.S.

    2017-02-10

    MoEDAL is designed to identify new physics in the form of long-lived highly-ionising particles produced in high-energy LHC collisions. Its arrays of plastic nuclear-track detectors and aluminium trapping volumes provide two independent passive detection techniques. We present here the results of a search for magnetic monopole production in 13 TeV proton-proton collisions using the trapping technique, extending a previous publication with 8~TeV data during LHC run-1. A total of 222~kg of MoEDAL trapping detector samples were exposed in the forward region and analysed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges exceeding half the Dirac charge are excluded in all samples and limits are placed for the first time on the production of magnetic monopoles in 13 TeV collisions. The search probes mass ranges previously inaccessible to collider experiments for up to five times the Dirac charge.

  2. Electron Cloud Generation and Trapping in a Quadrupole Magnet at the Los Alamos Proton Storage Ring

    International Nuclear Information System (INIS)

    Macek, Robert J.; Browman, Andrew A.; Ledford, John E.; TechSource, Santa Fe; Los Alamos; Borden, Michael J.; O'Hara, James F.; McCrady, Rodney C.; Rybarcyk, Lawrence J.; Spickermann, Thomas; Zaugg, Thomas J.; Pivi, Mauro T.F.

    2008-01-01

    Recent beam physics studies on the two-stream e-p instability at the LANL proton storage ring (PSR) have focused on the role of the electron cloud generated in quadrupole magnets where primary electrons, which seed beam-induced multipacting, are expected to be largest due to grazing angle losses from the beam halo. A new diagnostic to measure electron cloud formation and trapping in a quadrupole magnet has been developed, installed, and successfully tested at PSR. Beam studies using this diagnostic show that the 'prompt' electron flux striking the wall in a quadrupole is comparable to the prompt signal in the adjacent drift space. In addition, the 'swept' electron signal, obtained using the sweeping feature of the diagnostic after the beam was extracted from the ring, was larger than expected and decayed slowly with an exponential time constant of 50 to 100 (micro)s. Other measurements include the cumulative energy spectra of prompt electrons and the variation of both prompt and swept electron signals with beam intensity. Experimental results were also obtained which suggest that a good fraction of the electrons observed in the adjacent drift space for the typical beam conditions in the 2006 run cycle were seeded by electrons ejected from the quadrupole

  3. Proton nuclear magnetic resonance study on the barrier function of pig corneal epithelium and endothelium

    International Nuclear Information System (INIS)

    Yokoi, Norihiko; Kinoshita, Shigeru; Morimoto, Taketoshi; Yoshizaki, Kazuo.

    1995-01-01

    Using gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) as a tracer, the barrier function of the corneal epithelium and endothelium was evaluated by proton nuclear magnetic resonance. Whole pig eyes and cornea excised with scleral rim, which had been incubated in dextran-added Gd-DTPA solution, were subjected to T 1 relaxation measurement and magnetic resonance imaging (MRI). After incubation, the T 1 relaxation rate (1/T 1 ) of the excised cornea increased to a steady value, whereas that of the cornea from the whole eye increased only slightly. These results indicated that the increase in the T 1 relaxation rate of the excised cornea was attributable to Gd-DTPA penetration from the corneal endothelium and that the corneal epithelium exhibited a strong barrier function against Gd-DTPA entry. The MRI study also confirmed the strong barrier, enhanced signals being detected within the aqueous fluid in the T 1 -weighted image only when the corneal epithelium was abraded. Since Gd-DTPA scarcely penetrates the intact corneal epithelium, Gd-DTPA-enhanced MRI shows potential as a quantitative tracer in evaluating epithelial barrier disruption. (author)

  4. Electron cloud generation and trapping in a quadrupole magnet at the Los Alamos proton storage ring

    Directory of Open Access Journals (Sweden)

    Robert J. Macek

    2008-01-01

    Full Text Available Recent beam physics studies on the two-stream e-p instability at the LANL proton storage ring (PSR have focused on the role of the electron cloud generated in quadrupole magnets where primary electrons, which seed beam-induced multipacting, are expected to be largest due to grazing angle losses from the beam halo. A new diagnostic to measure electron cloud formation and trapping in a quadrupole magnet has been developed, installed, and successfully tested at PSR. Beam studies using this diagnostic show that the “prompt” electron flux striking the wall in a quadrupole is comparable to the prompt signal in the adjacent drift space. In addition, the “swept” electron signal, obtained using the sweeping feature of the diagnostic after the beam was extracted from the ring, was larger than expected and decayed slowly with an exponential time constant of 50 to 100  μs. Other measurements include the cumulative energy spectra of prompt electrons and the variation of both prompt and swept electron signals with beam intensity. Experimental results were also obtained which suggest that a good fraction of the electrons observed in the adjacent drift space for the typical beam conditions in the 2006 run cycle were seeded by electrons ejected from the quadrupole.

  5. The HERMES recoil photon detector and the study of deeply virtual Compton scattering

    Energy Technology Data Exchange (ETDEWEB)

    Hulse, Charlotte van

    2011-03-15

    The study of deeply virtual Compton scattering (DVCS) gives information about the contribution of the quark orbital angular momentum to the spin of the proton. DVCS has been studied at the HERMES experiment at DESY in Hamburg. Here 27.6 GeV longitudinally polarized electrons and positrons were scattered off a gaseous proton target. For the analysis of DVCS the recoiling proton could not be detected, but was reconstructed via its missing mass. This method suffers, however, from a 14% background contribution, mainly originating from associated DVCS. In this process the proton does not stay in its ground state but is excited to a {delta}{sup +} resonance. In order to reduce the background contribution down to less than 1%, a recoil detector was installed in the HERMES experiment beginning of 2006. This detector consists of three subcomponents, of which one is the photon detector. The main function of the photon detector is the detection of {delta}{sup +} decay photons. The photon detector was started up and commissioned for the analysis of (associated) DVCS. Subsequently DVCS and associated DVCS were analyzed using the recoil detector. (orig.)

  6. Search for magnetic monopoles with the MoEDAL prototype trapping detector in 8 TeV proton-proton collisions at the LHC

    Science.gov (United States)

    Acharya, B.; Alexandre, J.; Bendtz, K.; Benes, P.; Bernabéu, J.; Campbell, M.; Cecchini, S.; Chwastowski, J.; Chatterjee, A.; de Montigny, M.; Derendarz, D.; De Roeck, A.; Ellis, J. R.; Fairbairn, M.; Felea, D.; Frank, M.; Frekers, D.; Garcia, C.; Giacomelli, G.; Hasegan, D.; Kalliokoski, M.; Katre, A.; Kim, D.-W.; King, M. G. L.; Kinoshita, K.; Lacarrère, D. H.; Lee, S. C.; Leroy, C.; Lionti, A.; Margiotta, A.; Mauri, N.; Mavromatos, N. E.; Mermod, P.; Milstead, D.; Mitsou, V. A.; Orava, R.; Parker, B.; Pasqualini, L.; Patrizii, L.; Păvălas, G. E.; Pinfold, J. L.; Platkevič, M.; Popa, V.; Pozzato, M.; Pospisil, S.; Rajantie, A.; Sahnoun, Z.; Sakellariadou, M.; Sarkar, S.; Semenoff, G.; Sirri, G.; Sliwa, K.; Soluk, R.; Spurio, M.; Srivastava, Y. N.; Staszewski, R.; Suk, M.; Swain, J.; Tenti, M.; Togo, V.; Trzebinski, M.; Tuszynski, J. A.; Vento, V.; Vives, O.; Vykydal, Z.; Whyntie, T.; Widom, A.; Willems, G.; Yoon, J. H.

    2016-08-01

    The MoEDAL experiment is designed to search for magnetic monopoles and other highly-ionising particles produced in high-energy collisions at the LHC. The largely passive MoEDAL detector, deployed at Interaction Point 8 on the LHC ring, relies on two dedicated direct detection techniques. The first technique is based on stacks of nucleartrack detectors with surface area ~18m2, sensitive to particle ionisation exceeding a high threshold. These detectors are analysed offline by optical scanning microscopes. The second technique is based on the trapping of charged particles in an array of roughly 800 kg of aluminium samples. These samples are monitored offline for the presence of trapped magnetic charge at a remote superconducting magnetometer facility. We present here the results of a search for magnetic monopoles using a 160 kg prototype MoEDAL trapping detector exposed to 8TeV proton-proton collisions at the LHC, for an integrated luminosity of 0.75 fb-1. No magnetic charge exceeding 0:5 g D (where g D is the Dirac magnetic charge) is measured in any of the exposed samples, allowing limits to be placed on monopole production in the mass range 100 GeV≤ m ≤ 3500 GeV. Model-independent cross-section limits are presented in fiducial regions of monopole energy and direction for 1 g D ≤ | g| ≤ 6 g D, and model-dependent cross-section limits are obtained for Drell-Yan pair production of spin-1/2 and spin-0 monopoles for 1 g D ≤ | g| ≤ 4 g D. Under the assumption of Drell-Yan cross sections, mass limits are derived for | g| = 2 g D and | g| = 3 g D for the first time at the LHC, surpassing the results from previous collider experiments.

  7. A free-jet Hg target operating in a high magnetic field intersecting a high-power proton beam

    Science.gov (United States)

    Van Graves; Spampinato, Philip; Gabriel, Tony; Kirk, Harold; Simos, Nicholas; Tsang, Thomas; McDonald, Kirk; Peter Titus; Fabich, Adrian; Haseroth, Helmut; Lettry, Jacques

    2006-06-01

    A proof-of-principal experiment to investigate the interaction of a proton beam, high magnetic field, and high- Z target is planned to take place at CERN in early 2007. This experiment is part of the Muon Collider Collaboration, with participants from Brookhaven National Laboratory, Princeton University, Massachusetts Institute Of Technology, European Organization for Nuclear Research-CERN, Rutherford Appleton Laboratory, and Oak Ridge National Laboratory. An unconstrained mercury jet target system that interacts with a high power (1 MW) proton beam in a high magnetic field (15 T) is being designed. The Hg jet diameter is 1-cm with a velocity up to 20 m/s. A laser optical diagnostic system will be incorporated into the target design to permit observation of the dispersal of the jet resulting from interaction with a 24 GeV proton beam with up to 20×10 12 ppp. The target system includes instruments for sensing mercury vapor, temperature, flow rate, and sump tank level, and the means to position the jet relative to the magnetic axis of a solenoid and the proton beam. The design considerations for the system include all issues dealing with safely handling approximately 23 l of Hg, transporting the target system and the mercury to CERN, decommissioning the experiment, and returning the mildly activated equipment and Hg to the US.

  8. Ground-state magnetization of the molecular cluster Mn12O12-acetate as seen by proton NMR

    International Nuclear Information System (INIS)

    Furukawa, Y.; Watanabe, K.; Kumagai, K.; Jang, Z. H.; Lascialfari, A.; Borsa, F.; Gatteschi, D.

    2000-01-01

    1 H nuclear magnetic resonance (NMR) measurements have been carried out in Mn 12 O 12 -acetate clusters at low temperature in order to investigate microscopically the static and dynamic magnetic properties of the molecule in its high-spin S=10 ground state. Below liquid helium temperature it is found that the local hyperfine fields at the proton sites are static as expected for the very slow superparamagnetic relaxation of Mn 12 O 12 at low temperature. The magnitude and distribution of the hyperfine fields can be reproduced to a good approximation by considering only the dipolar interaction of protons with the local Mn magnetic moments and by assigning the magnitude and orientation of the local moments of the different Mn 3+ and Mn 4+ ions according to an accepted coupling scheme for the total S=10 ground state. The relaxation time of the macroscopic magnetization of the cluster was measured by monitoring the change of the intensity of the 1 H-NMR shifted lines following inversion of the applied magnetic field. This is possible because the sudden change of the field orientation changes the sign of the shift of the NMR lines in the proton spectrum. Although important differences are noticed, the relaxation time of the magnetization as measured indirectly by the 1 H-NMR method is comparable to the one obtained directly with a superconducting quantum interference device magnetometer. In particular we could reproduce the minima in the relaxation time as a function of magnetic field at the fields for level crossing, minima which are considered to be a signature of the quantum tunneling of the magnetization

  9. TU-H-CAMPUS-TeP1-03: Magnetically Focused Proton Irradiation of Small Volume Radiosurgery Targets

    Energy Technology Data Exchange (ETDEWEB)

    McAuley, GA; Slater, JM [Loma Linda University, Loma Linda, CA (United States); Wroe, AJ [Loma Linda University, Loma Linda, CA (United States); Loma Linda University Medical Center, Loma Linda, CA (United States)

    2016-06-15

    Purpose: To investigate the use of magnetic focusing for small volume proton radiosurgery targets using a triplet combination of quadrupole rare earth permanent magnet Halbach cylinder assemblies Methods: Fourteen quadrupole magnets consisting of 24 segments of radiation hard samarium-cobalt adhered into k=3 Halbach cylinders with various field gradients (100 to 250 T/m) were designed and manufactured. Triplet combinations of the magnets were placed on a positioning track on our Gantry 1 treatment table. Unmodulated 127 MeV proton beams with initial diameters of 3 to 20 mm were delivered to a water tank using single-stage scattering. Depth and transverse dose distributions were measured using a PTW PR60020 diode detector and EBT3 film, respectively. This data was compared with unfocused passively collimated beams. Monte Carlo simulations were also performed - both for comparison with experimental data and to further investigate the potential of triplet magnetic focusing. Results: Experimental results using 150 T/m gradient magnets and 15 to 20 mm initial diameter beams show peak to entrance dose ratios that are ∼ 43 to 48 % larger compared with spot size matched 8 mm collimated beams (ie, transverse profile full-widths at 90% maximum dose match within 0.5 mm of focused beams). In addition, the focusing beams were ∼ 3 to 4.4 times more efficient per MU in dose to target delivery. Additional results using different magnet combinations will also be presented. Conclusion: Our results suggest that triplet magnetic focusing could reduce entrance dose and beam number while delivering dose to small (∼≤ 10 mm diameter) radiosurgery targets in less time compared to unfocused beams. Immediate clinical applications include those associated with proton radiosurgery and functional radiosurgery of the brain and spine, however other treatment sites can be also envisioned. This project was sponsored with funding from the Department of Defense (DOD# W81XWH-BAA-10-1).

  10. The hippocampus in patients treated with electroconvulsive therapy: a proton magnetic resonance spectroscopic imaging study.

    Science.gov (United States)

    Ende, G; Braus, D F; Walter, S; Weber-Fahr, W; Henn, F A

    2000-10-01

    We monitored the effect of electroconvulsive therapy (ECT) on the nuclear magnetic resonance-detectable metabolites N-acetylaspartate, creatine and phosphocreatine, and choline-containing compounds in the hippocampus by means of hydrogen 1 magnetic resonance spectroscopic imaging. We hypothesized that if ECT-induced memory deterioration was associated with neuronal loss in the hippocampus, the N-acetylaspartate signal would decrease after ECT and any increased membrane turnover would result in an increase in the signal from choline-containing compounds. Seventeen patients received complete courses of ECT, during which repeated proton magnetic resonance spectroscopic imaging studies of the hippocampal region were performed. Individual changes during the course of ECT were compared with values obtained in 24 healthy control subjects and 6 patients remitted from major depression without ECT. No changes in the hippocampal N-acetylaspartate signals were detected after ECT. A significant mean increase of 16% of the signal from choline-containing compounds after 5 or more ECT treatments was observed. Despite the mostly unilateral ECT application (14 of 17 patients), the increase in the choline-containing compound signal was observed bilaterally. Lactate or elevated lipid signals were not detected. All patients showed clinical amelioration of depression after ECT. Electroconvulsive therapy is not likely to induce hippocampal atrophy or cell death, which would be reflected by a decrease in the N-acetylaspartate signal. Compared with an age-matched control group, the choline-containing compounds signal in patients with a major depressive episode was significantly lower than normal, before ECT and normalized during ECT.

  11. Commissioning of the recoil silicon detector for the HERMES experiment

    International Nuclear Information System (INIS)

    Pickert, N.C.

    2008-02-01

    The reconstruction of the missing mass is limited by the position and momentum resolution of the HERMES spectrometer. In order to reach a higher accuracy in the measurements the backscattered nucleon must also be detected. A detector suited for this must give the possibility, to determine the momentum of the particles over a very large range: from minimally ionizing particles up to protons, which are stopped in the detector. The detector must also be able to discriminate hadrons and mesons as well as cover the complete spatial region around the target. In the winter 2005-2006 such a recoil detector was installed in the HERMES experiment. The detector sonsists of three partial detectors, a silicon counter within the scattering chamber, a sintillating-fiber detector and a photon detector. Before the installation of the detector the silicon modules were tested in a bench test and checked together with the other particle detectors in a test experiment. A large part of this dissertation is dedicated to the planning and performance of these tests as well to the evaluation of them. It could be show, that the modules worked accordly to their specifications, however because of unexpectedly high noise a signal correction became necessary. Different models for the correction were developed and tested in the framework of these thesis. In spite of the high noise cosmic muons could be detected and their energy deposition measured with a signal-to-noise ratio of 2:1. In the winter break 2005-2006 the recoil detector was installed into the HERMES experiment. First diagnosis and analysis software was developed. The silicon detector measured successfully energy depositions of minimally ionizing particles up to protons stopped in the sensor. Minimally ionizing particles could be detected with a signal-to-noise ratio of 5:1. By means of track information of the scintillating-fiber detector protons could be discriminated from pions and other mesons by the silicon detector. The HERMES

  12. Commissioning of the recoil silicon detector for the HERMES experiment

    Energy Technology Data Exchange (ETDEWEB)

    Pickert, N C

    2008-02-15

    The reconstruction of the missing mass is limited by the position and momentum resolution of the HERMES spectrometer. In order to reach a higher accuracy in the measurements the backscattered nucleon must also be detected. A detector suited for this must give the possibility, to determine the momentum of the particles over a very large range: from minimally ionizing particles up to protons, which are stopped in the detector. The detector must also be able to discriminate hadrons and mesons as well as cover the complete spatial region around the target. In the winter 2005-2006 such a recoil detector was installed in the HERMES experiment. The detector sonsists of three partial detectors, a silicon counter within the scattering chamber, a sintillating-fiber detector and a photon detector. Before the installation of the detector the silicon modules were tested in a bench test and checked together with the other particle detectors in a test experiment. A large part of this dissertation is dedicated to the planning and performance of these tests as well to the evaluation of them. It could be show, that the modules worked accordly to their specifications, however because of unexpectedly high noise a signal correction became necessary. Different models for the correction were developed and tested in the framework of these thesis. In spite of the high noise cosmic muons could be detected and their energy deposition measured with a signal-to-noise ratio of 2:1. In the winter break 2005-2006 the recoil detector was installed into the HERMES experiment. First diagnosis and analysis software was developed. The silicon detector measured successfully energy depositions of minimally ionizing particles up to protons stopped in the sensor. Minimally ionizing particles could be detected with a signal-to-noise ratio of 5:1. By means of track information of the scintillating-fiber detector protons could be discriminated from pions and other mesons by the silicon detector. The HERMES

  13. Chiral discrimination of sibutramine enantiomers by capillary electrophoresis and proton nuclear magnetic resonance spectroscopy.

    Science.gov (United States)

    Lee, Yong-Jae; Choi, Seungho; Lee, Jinhoo; Nguyen, NgocVan Thi; Lee, Kyungran; Kang, Jong Seong; Mar, Woongchon; Kim, Kyeong Ho

    2012-03-01

    Capillary electrophoresis (CE) and proton nuclear magnetic resonance spectroscopy ((1)H-NMR) have been used to discriminate the enantiomers of sibutramine using cyclodextrin derivatives. Possible correlation between CE and (1)H-NMR was examined. Good correlation between the (1)H-NMR shift non-equivalence data for sibutramine and the degree of enantioseparation in CE was observed. In CE study, a method of enantiomeric separation and quantitation of sibutramine was developed using enantiomeric standards. The method was based on the use of 50 mM of phosphate buffer of pH 3.0 with 10 mM of methyl-beta-cyclodextrin (M-β-CD). 0.05% of LOD, 0.2% of LOQ for S-sibutramine enantiomer was achieved, and the method was validated and applied to the quantitative determination of sibutramine enantiomers in commercial drugs. On a 600 MHz (1)H-NMR analysis, enantiomer signal separation of sibutramine was obtained by fast diastereomeric interaction with a chiral selector M-β-CD. For chiral separation and quantification, N-methyl proton peaks (at 2.18 ppm) were selected because of its being singlet and simple for understanding of diastereomeric interaction. Effects of temperature and concentration of chiral selector on enantiomer signal separation were investigated. The optimum condition was 0.5 mg/mL of sibutramine and 10 mg/mL of M-β-CD at 10°C. Distinguishment of 0.5% of S-sibutramine in R-sibutramine was found to be possible by (1)H-NMR with M-β-CD as chiral selector. Host-guest interaction between sibutramine and M-β-CD was confirmed by (1)H-NMR studies and CE studies. A Structure of the inclusion complex was proposed considering (1)H-NMR and 2D ROESY studies.

  14. Effects of proton irradiation on structure of NdFeB permanent magnets studied by X-ray diffraction and X-ray absorption fine structure

    International Nuclear Information System (INIS)

    Yang, L.; Zhen, L.; Xu, C.Y.; Sun, X.Y.; Shao, W.Z.

    2011-01-01

    The effects of proton irradiation on the structure of NdFeB permanent magnet were investigated by X-ray diffraction and X-ray absorption fine structure (XAFS). The results reveal that proton irradiation has no effect on the long-range structure, but significantly affects the atomic local structure of the NdFeB magnet. The alignment degree of the magnet decreases and the internal stress of the lattice increases after proton irradiation. XAFS results show that the coordination number of Fe-Nd in the first neighboring coordination shell of the Fe atoms decreases and the disorder degree increases.

  15. Effects of proton irradiation on structure of NdFeB permanent magnets studied by X-ray diffraction and X-ray absorption fine structure

    Energy Technology Data Exchange (ETDEWEB)

    Yang, L. [School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001 (China); Zhen, L., E-mail: lzhen@hit.edu.c [School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001 (China); Xu, C.Y.; Sun, X.Y.; Shao, W.Z. [School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001 (China)

    2011-01-15

    The effects of proton irradiation on the structure of NdFeB permanent magnet were investigated by X-ray diffraction and X-ray absorption fine structure (XAFS). The results reveal that proton irradiation has no effect on the long-range structure, but significantly affects the atomic local structure of the NdFeB magnet. The alignment degree of the magnet decreases and the internal stress of the lattice increases after proton irradiation. XAFS results show that the coordination number of Fe-Nd in the first neighboring coordination shell of the Fe atoms decreases and the disorder degree increases.

  16. A Measurement of the Recoil Polarization of Electroproduced Λ(1116)

    Energy Technology Data Exchange (ETDEWEB)

    McAleer, Simeon B. [Florida State Univ., Tallahassee, FL (United States)

    2002-01-01

    The CEBAF Large Acceptance Spectrometer at the Thomas Jefferson National Laboratory was used to study the reaction e + p → e' + K+ + Λ(1116) for events where Λ(1116) subsequently decayed via the channel Λ(1116) → p + π-. Data were taken at incident electron beam energies of 2.5, 4.0, and 4.2 GeV during the 1999 E1C run period. They hyperon production spectra span the Q2 range from 0.5 to 2.8 GeV2 and nearly the entire range in the center of mass angles. The proton angular distribution in the Λ(1116) rest frame is used to deduce the recoil polarization of the hyperon, and the W and cos θ$K+\\atop{cm}$ dependence of the recoil polarization will be presented. The data show sizeable negative polarizations for the Λ(1116) as a function of both cos θ$K+\\atop{cm}$ and W.

  17. Status of intense permanent magnet proton source for China-accelerator driven sub-critical system Linac.

    Science.gov (United States)

    Wu, Q; Ma, H Y; Yang, Y; Sun, L T; Zhang, X Z; Zhang, Z M; Zhao, H Y; He, Y; Zhao, H W

    2016-02-01

    Two compact intense 2.45 GHz permanent magnet proton sources and their corresponding low energy beam transport (LEBT) system were developed successfully for China accelerator driven sub-critical system in 2014. Both the proton sources operate at 35 kV potential. The beams extracted from the ion source are transported by the LEBT, which is composed of two identical solenoids, to the 2.1 MeV Radio-Frequency Quadrupole (RFQ). In order to ensure the safety of the superconducting cavities during commissioning, an electrostatic-chopper has been designed and installed in the LEBT line that can chop the continuous wave beam into a pulsed one. The minimum width of the pulse is less than 10 μs and the fall/rise time of the chopper is about 20 ns. The performance of the proton source and the LEBT, such as beam current, beam profile, emittance and the impact to RFQ injection will be presented.

  18. Status of intense permanent magnet proton source for China-accelerator driven sub-critical system Linac

    Science.gov (United States)

    Wu, Q.; Ma, H. Y.; Yang, Y.; Sun, L. T.; Zhang, X. Z.; Zhang, Z. M.; Zhao, H. Y.; He, Y.; Zhao, H. W.

    2016-02-01

    Two compact intense 2.45 GHz permanent magnet proton sources and their corresponding low energy beam transport (LEBT) system were developed successfully for China accelerator driven sub-critical system in 2014. Both the proton sources operate at 35 kV potential. The beams extracted from the ion source are transported by the LEBT, which is composed of two identical solenoids, to the 2.1 MeV Radio-Frequency Quadrupole (RFQ). In order to ensure the safety of the superconducting cavities during commissioning, an electrostatic-chopper has been designed and installed in the LEBT line that can chop the continuous wave beam into a pulsed one. The minimum width of the pulse is less than 10 μs and the fall/rise time of the chopper is about 20 ns. The performance of the proton source and the LEBT, such as beam current, beam profile, emittance and the impact to RFQ injection will be presented.

  19. Status of intense permanent magnet proton source for China-accelerator driven sub-critical system Linac

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Q., E-mail: wuq@impcas.ac.cn; Ma, H. Y.; Yang, Y.; Sun, L. T.; Zhang, X. Z.; Zhang, Z. M.; Zhao, H. Y.; He, Y.; Zhao, H. W. [Institute of Modern Physics (IMP), Chinese Academy of Sciences, Lanzhou 730000 (China)

    2016-02-15

    Two compact intense 2.45 GHz permanent magnet proton sources and their corresponding low energy beam transport (LEBT) system were developed successfully for China accelerator driven sub-critical system in 2014. Both the proton sources operate at 35 kV potential. The beams extracted from the ion source are transported by the LEBT, which is composed of two identical solenoids, to the 2.1 MeV Radio-Frequency Quadrupole (RFQ). In order to ensure the safety of the superconducting cavities during commissioning, an electrostatic-chopper has been designed and installed in the LEBT line that can chop the continuous wave beam into a pulsed one. The minimum width of the pulse is less than 10 μs and the fall/rise time of the chopper is about 20 ns. The performance of the proton source and the LEBT, such as beam current, beam profile, emittance and the impact to RFQ injection will be presented.

  20. Direct measurement of kilo-tesla level magnetic field generated with laser-driven capacitor-coil target by proton deflectometry

    Science.gov (United States)

    Law, K. F. F.; Bailly-Grandvaux, M.; Morace, A.; Sakata, S.; Matsuo, K.; Kojima, S.; Lee, S.; Vaisseau, X.; Arikawa, Y.; Yogo, A.; Kondo, K.; Zhang, Z.; Bellei, C.; Santos, J. J.; Fujioka, S.; Azechi, H.

    2016-02-01

    A kilo-tesla level, quasi-static magnetic field (B-field), which is generated with an intense laser-driven capacitor-coil target, was measured by proton deflectometry with a proper plasma shielding. Proton deflectometry is a direct and reliable method to diagnose strong, mm3-scale laser-produced B-field; however, this was not successful in the previous experiment. A target-normal-sheath-accelerated proton beam is deflected by Lorentz force in the laser-produced magnetic field with the resulting deflection pattern recorded on a radiochromic film stack. A 610 ± 30 T of B-field amplitude was inferred by comparing the experimental proton pattern with Monte-Carlo calculations. The amplitude and temporal evolutions of the laser-generated B-field were also measured by a differential magnetic probe, independently confirming the proton deflectometry measurement results.

  1. Noninvasive evaluation of adult onset myopathy from carnitine palmitoyl transferase II deficiency using proton magnetic resonance spectroscopy.

    Science.gov (United States)

    Videen, J S; Haseler, L J; Karpinski, N C; Terkeltaub, R A

    1999-08-01

    The adult onset metabolic myopathy of carnitine palmitoyl transferase II (CPT II) deficiency is under-recognized, in part due to variable degrees of enzyme deficiency and symptomatology, as well as limitations in means for noninvasive evaluation. We describe a proton magnetic resonance spectroscopy (MRS) technique, using a standard clinical magnetic resonance imaging scanner, to diagnose and help monitor the response to therapy in adult CPT II deficiency. A 53-year-old woman presented with a long standing history of diffuse aching and fatigue provoked by high fat intake, fasting, or prolonged exertion. Muscle biopsy revealed myopathic features and a deficiency (33% of control) of CPT II activity with elevated palmitoyl carnitine. Proton MRS of the soleus muscle was performed using a 1.5 Tesla scanner before and during dietary therapy. Proton MRS revealed shortening of the transverse relaxation time (T2), consistent with increased acetylation of the carnitine pool. The symptoms resolved completely by treatment with frequent feedings of a high carbohydrate diet low in long chain fatty acids supplemented with medium chain triglycerides and L-carnitine. Recovery of normal muscle MRS and carnitine T2 relaxation was documented by the third month of therapy. Proton MRS is a novel, potentially useful, and readily available adjunct in the diagnosis and therapeutic monitoring of muscle CPT II deficiency.

  2. Diffusion-weighted imaging and magnetic resonance proton spectroscopy following preterm birth

    International Nuclear Information System (INIS)

    Hart, A.R.; Smith, M.F.; Whitby, E.H.; Alladi, S.; Wilkinson, S.; Paley, M.N.; Griffiths, P.D.

    2014-01-01

    Aim: To study the associations between magnetic resonance proton spectroscopy (MRS) data and apparent diffusion coefficients (ADC) from the preterm brain with developmental outcome at 18 months corrected age and clinical variables. Materials and methods: A prospective observational cohort study of 67 infants born before 35 weeks gestational age who received both magnetic resonance imaging of the brain between 37 and 44 weeks corrected gestational age and developmental assessment around 18 months corrected age. Results: No relationships were found between ADC values and MRS results or outcome. MRS ratios involving N-acetyl aspartate (NAA) from the posterior white matter were associated with ''severe'' and ''moderate to severe'' difficulties, and fine motor scores were significantly lower in participants with a visible lactate doublet in the posterior white matter. The presence of a patent ductus arteriosus (PDA) was the only clinical factor related to NAA ratios. Conclusion: Altered NAA levels in the posterior white matter may reflect subtle white matter injury associated with neuro-developmental difficulties, which may be related to a PDA. Further work is needed to assess the longer-term neuro-developmental implications of these findings, and to study the effect of PDAs on developmental outcome in later childhood/adolescence. - Highlights: • ADC values around term corrected age from a wide area of the brain are not associated with developmental outcome. • NAA ratios from the posterior white matter are associated with adverse outcome. • No relationship between MRS data and ADC values exist when measured from the same region of the cerebral white matter. • The presence of a patent ductus arterious was associated with NAA ratios from the posterior white matter, but not outcome

  3. Analysis of the brain proton magnetic resonance spectroscopy - differences between normal grey and white matter

    International Nuclear Information System (INIS)

    Krukowski, P.; Podgorski, P.; Guzinski, M.; Szewczyk, P.; Sasiadek, M.

    2010-01-01

    Background: The proton magnetic resonance spectroscopy (HMRS) is a non-invasive diagnostic method that allows for an assessment of the metabolite concentration in tissues. The sources of the strongest resonance signals within the brain are N-acetylaspartate (NAA), creatine (Cr), choline (Cho), myoinositol (mI) and water. The aim of our study was to analyse the ratios of metabolite signals within the brain in HMRS in the healthy population, to define the differences between the grey and white matter spectra. Material/Methods: We studied prospectively 90 subjects aged from 8 to 80 years (mean 43.3 years, SD=17.9), without neurological symptoms or abnormalities in magnetic resonance imaging. In all patients, brain HMRS with Signa HDx 1.5 T MR unit (GE Healthcare) was performed with PRESS sequence, using a single voxel method, at TE of 35 ms and TR of 1500 ms. Spectroscopic evaluation involved voxels placed in the white matter of parietal lobe (PWM) and the grey matter of posterior cingulate gyrus (PGM). On the basis of the intensity of NAA, Cr, Cho, mI and water signals, the proportions of these signals were calculated, as well as the ratio of the analyzed metabolite signal to the sum of signals of NAA, Cho, Cr and mI (%Met) in the PGM and PWM voxels. We compared the proportions in the same patients in PGM and PWM voxels. Results: There has been a statistically significant difference between the proportions of a majority of the metabolite ratios evaluated in PGM and PWM, indicating the higher concentration of NAA, Cr and mI in grey matter, and higher concentration of Cho in white matter. Conclusions: HMRS spectra of the brain grey and white matter differ significantly. The concentrations of NAA, Cr and mI are higher in grey matter, while of choline - in the white matter. (authors)

  4. Recoil detector test for the day-one experiment at HESR

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Qiang [Institute of Modern Physics, CAS, 730000 Lanzhou (China); Forschungszentrum Juelich, 52425 Juelich (Germany); Xu, Huagen; Ritman, James [Forschungszentrum Juelich, 52425 Juelich (Germany)

    2013-07-01

    The proposed day-one experiment at HESR is a dedicated measurement of antiproton-proton elastic scattering. The aim of the day-one experiment is to determine the elastic differential parameters (total cross section σ{sub T}, the ratio of real to imaginary part of the forward scattering amplitude ρ, and the slope parameter B) by measuring a large range of 4-momentum transfer squared t (0.0008-0.1 GeV{sup 2}). The conceptual design of the day-one experiment is to measure the elastic scattered antiproton and recoil proton, by a tracking detector in the small polar angle range and by an energy detector near 90 , respectively. The recoil arm covers a maximum polar angle range from 71 to 90 and consists of two silicon strip detectors (76.8(length) x 50.0(width) x 1.0(thickness) mm{sup 3}) and two germanium detectors (80.4(length) x 50.0(width) x 5.0 (11.0) (thickness) mm{sup 3}). All detectors are single sided structure with 1.2 mm pitch. The silicon detectors will be used to detect recoil protons with energy up to about 12 MeV and the germanium detectors will be used to detect protons with energy from 12 MeV to 60 MeV. At present, one recoil arm is being constructed and the test for the detectors with radioactive sources is on-going. Preliminary test results indicate that all detectors are operational and work properly. The latest test results of these detectors are presented.

  5. Double-trap measurement of the proton magnetic moment at 0.3 parts per billion precision.

    Science.gov (United States)

    Schneider, Georg; Mooser, Andreas; Bohman, Matthew; Schön, Natalie; Harrington, James; Higuchi, Takashi; Nagahama, Hiroki; Sellner, Stefan; Smorra, Christian; Blaum, Klaus; Matsuda, Yasuyuki; Quint, Wolfgang; Walz, Jochen; Ulmer, Stefan

    2017-11-24

    Precise knowledge of the fundamental properties of the proton is essential for our understanding of atomic structure as well as for precise tests of fundamental symmetries. We report on a direct high-precision measurement of the magnetic moment μ p of the proton in units of the nuclear magneton μ N The result, μ p = 2.79284734462 (±0.00000000082) μ N , has a fractional precision of 0.3 parts per billion, improves the previous best measurement by a factor of 11, and is consistent with the currently accepted value. This was achieved with the use of an optimized double-Penning trap technique. Provided a similar measurement of the antiproton magnetic moment can be performed, this result will enable a test of the fundamental symmetry between matter and antimatter in the baryonic sector at the 10 -10 level. Copyright © 2017, American Association for the Advancement of Science.

  6. [Clinical application of proton magnetic resonance spectroscopy in children with idiopathic epilepsy].

    Science.gov (United States)

    Shao, Xiao-Li; Zhou, Zhong-Shu; Hong, Wen

    2010-06-01

    This study examined the biochemical metabolism by proton magnetic resonance spectroscopy ('H-MRS) in order to explore the value of 'H-MRS in idiopathic epilepsy in children. Thirty-three children with idiopathic epilepsy (14 cases with history of febrile seizures and 19 cases without) and six normal controls experienced MRI of the skull and brain and single-voxel 'H-MRS examinations of the hippocampi-temporal lobe. The signal intensities of N-acetylaspartate (NAA), eatine+phosphocreatine (Cr), choline-containing compounds (Cho) and lactate (Lac) and the ratios of NAA/ (Cho+Cr) and Lac/Cr were compared between the patients and normal controls. MRI examination showed that only one child with epilepsy had myelin dysplasia. 'H-MRS examination showed that the ratio of NAA/ (Cho+Cr) in the epilepsy group was lower than that in the control group (0.64+/-0.07 vs 0.73+/-0.05; Pepilepsy and the control groups. 'H-MRS may provide early information on brain injury sensitively and non-invasively in children with epilepsy. It may be used for diagnosis and prognosis evaluation of epilepsy.

  7. Proton magnetic resonance with parahydrogen induced polarization. Imaging strategies and continuous generation

    Energy Technology Data Exchange (ETDEWEB)

    Dechent, Jan Falk Frederik

    2012-12-17

    A major challenge in imaging is the detection of small amounts of molecules of interest. In the case of magnetic resonance imaging (MRI) their signals are typically concealed by the large background signal of e.g. the tissue of the body. This problem can be tackled by hyperpolarization which increases the NMR signals up to several orders of magnitude. However, this strategy is limited for {sup 1}H, the most widely used nucleus in NMR and MRI, because the enormous number of protons in the body screen the small amount of hyperpolarized ones. Here, I describe a method giving rise to high {sup 1}H MRI contrast for hyperpolarized molecules against a large background signal. The contrast is based on the J-coupling induced rephasing of the NMR signal of molecules hyperpolarized via parahydrogen induce polarization (PHIP) and it can easily be implemented in common pulse sequences. Hyperpolarization methods typically require expensive technical equipment (e.g. lasers or microwaves) and most techniques work only in batch mode, thus the limited lifetime of the hyperpolarization is limiting its applications. Therefore, the second part of my thesis deals with the simple and efficient generation of an hyperpolarization. These two achievements open up alternative opportunities to use the standard MRI nucleus {sup 1}H for e.g. metabolic imaging in the future.

  8. Proton magnetic resonance spectroscopy in children with fetal alcohol spectrum disorders

    Energy Technology Data Exchange (ETDEWEB)

    Goncalves, Rita de Cassia Ferreira; Vasconcelos, Marcio Moacyr; Faleiros, Leticia Oliveira; Brito, Adriana Rocha; Werner Junior, Jairo; Herdy, Gesmar Volga Haddad [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Faculdade de Medicina], e-mail: rcgonc@hotmail.com; Cruz Junior, Luiz Celso Hygino da; Domingues, Romeu Cortes [Multi-Imagem, Rio de Janeiro, RJ (Brazil)

    2009-06-15

    To analyze the metabolic constitution of brain areas through proton magnetic resonance spectroscopy in children affected with fetal alcohol spectrum disorder compared with normal children. Method: The sample of this case-control study included eight boys with epidemiologic history of in utero exposure to alcohol (median age 13.6{+-}3.8 years) who were diagnosed with fetal alcohol spectrum disorder, and eight controls (median age 12.1{+-}3,4 years). An 8 cm{sup 3} single voxel approach was used, with echo time 30 ms, repetition time 1500 ms, and 128 acquisitions in a 1.5T scanner, and four brain areas were analyzed: anterior cingulate, left frontal lobe, left striatum, and left cerebellar hemisphere. Peaks and ratios of metabolites N-acetylaspartate, choline, creatine, and myo-inositol were measured. Results: Children with fetal alcohol spectrum disorder showed a decrease in choline/creatine ratio (p=0.020) in left striatum and an increase in myo-inositol/creatine ratio (p=0.048) in left cerebellum compared with controls. There was no statistically significant difference in all peaks and ratios from the anterior cingulate and frontal lobe between the two groups. Conclusion: This study found evidence that the left striatum and left cerebellum are affected by intrauterine exposure to alcohol. Additional studies with larger samples are necessary to expand our knowledge of the effects of fetal exposure to alcohol. (author)

  9. Amide Proton Transfer (APT) MR imaging and Magnetization Transfer (MT) MR imaging of pediatric brain development

    International Nuclear Information System (INIS)

    Zhang, Hong; Kang, Huiying; Peng, Yun; Zhao, Xuna; Jiang, Shanshan; Zhang, Yi; Zhou, Jinyuan

    2016-01-01

    To quantify the brain maturation process during childhood using combined amide proton transfer (APT) and conventional magnetization transfer (MT) imaging at 3 Tesla. Eighty-two neurodevelopmentally normal children (44 males and 38 females; age range, 2-190 months) were imaged using an APT/MT imaging protocol with multiple saturation frequency offsets. The APT-weighted (APTW) and MT ratio (MTR) signals were quantitatively analyzed in multiple brain areas. Age-related changes in MTR and APTW were evaluated with a non-linear regression analysis. The APTW signals followed a decreasing exponential curve with age in all brain regions measured (R"2 = 0.7-0.8 for the corpus callosum, frontal and occipital white matter, and centrum semiovale). The most significant changes appeared within the first year. At maturation, larger decreases in APTW and lower APTW values were found in the white matter. On the contrary, the MTR signals followed an increasing exponential curve with age in the same brain regions measured, with the most significant changes appearing within the initial 2 years. There was an inverse correlation between the MTR and APTW signal intensities during brain maturation. Together with MT imaging, protein-based APT imaging can provide additional information in assessing brain myelination in the paediatric population. (orig.)

  10. Localised proton magnetic resonance spectroscopy of the brain after perinatal hypoxia: a preliminary report

    International Nuclear Information System (INIS)

    Chateil, J.F.; Quesson, B.; Thiaudiere, E.; Delalande, C.; Canioni, P.; Brun, M.; Diard, F.; Sarlangue, J.; Billeaud, C.

    1999-01-01

    Objectives. Perinatal hypoxic ischaemic injury is a significant cause of neurodevelopmental impairment. The aim of this study was to evaluate localised proton magnetic resonance spectroscopy ( 1 H-MRS) after birth asphyxia. Materials and methods. Thirty newborn infants suspected of having perinatal asphyxia (Apgar score 1 H-MRS was recorded in a single voxel, localised in white matter, using a STEAM sequence. Results. Image quality was good in 25 of 30 babies. 1 H-MRS was performed in 19 of 30 subjects, with adequate quality in 16. Choline, creatine/phosphocreatine and N-acetylaspartate peaks and peak-area ratios were analysed. Lactate was detected in four infants. The N-acetylaspartate/choline ratio was lower in infants with an impaired neurological outcome, but the difference was not statistically significant. Conclusions. This study suggests that 1 H-MRS may be useful for assessing cerebral metabolism in the neonate. A raised lactate level and decreased N-acetylaspartate/choline ratio may be predictive of a poor outcome. However, in our experience this method is limited by the difficulty in performing the examination during the first hours after birth in critically ill babies, the problems related to use of a monovoxel sequence, the dispersion of the ratios and the lack of determination of the absolute concentration of the metabolites. (orig.)

  11. Characterization of urban aerosol using aerosol mass spectrometry and proton nuclear magnetic resonance spectroscopy

    Science.gov (United States)

    Cleveland, M. J.; Ziemba, L. D.; Griffin, R. J.; Dibb, J. E.; Anderson, C. H.; Lefer, B.; Rappenglück, B.

    2012-07-01

    Particulate matter was measured during August and September of 2006 in Houston as part of the Texas Air Quality Study II Radical and Aerosol Measurement Project. Aerosol size and composition were determined using an Aerodyne quadrupole aerosol mass spectrometer. Aerosol was dominated by sulfate (4.1 ± 2.6 μg m-3) and organic material (5.5 ± 4.0 μg m-3), with contributions of organic material from both primary (˜32%) and secondary (˜68%) sources. Secondary organic aerosol appears to be formed locally. In addition, 29 aerosol filter samples were analyzed using proton nuclear magnetic resonance (1H NMR) spectroscopy to determine relative concentrations of organic functional groups. Houston aerosols are less oxidized than those observed elsewhere, with smaller relative contributions of carbon-oxygen double bonds. These particles do not fit 1H NMR source apportionment fingerprints for identification of secondary, marine, and biomass burning organic aerosol, suggesting that a new fingerprint for highly urbanized and industrially influenced locations be established.

  12. Proton magnetic resonance with parahydrogen induced polarization. Imaging strategies and continuous generation

    International Nuclear Information System (INIS)

    Dechent, Jan Falk Frederik

    2012-01-01

    A major challenge in imaging is the detection of small amounts of molecules of interest. In the case of magnetic resonance imaging (MRI) their signals are typically concealed by the large background signal of e.g. the tissue of the body. This problem can be tackled by hyperpolarization which increases the NMR signals up to several orders of magnitude. However, this strategy is limited for 1 H, the most widely used nucleus in NMR and MRI, because the enormous number of protons in the body screen the small amount of hyperpolarized ones. Here, I describe a method giving rise to high 1 H MRI contrast for hyperpolarized molecules against a large background signal. The contrast is based on the J-coupling induced rephasing of the NMR signal of molecules hyperpolarized via parahydrogen induce polarization (PHIP) and it can easily be implemented in common pulse sequences. Hyperpolarization methods typically require expensive technical equipment (e.g. lasers or microwaves) and most techniques work only in batch mode, thus the limited lifetime of the hyperpolarization is limiting its applications. Therefore, the second part of my thesis deals with the simple and efficient generation of an hyperpolarization. These two achievements open up alternative opportunities to use the standard MRI nucleus 1 H for e.g. metabolic imaging in the future.

  13. Fragile X syndrome: a pilot proton magnetic resonance spectroscopy study in premutation carriers

    LENUS (Irish Health Repository)

    Hallahan, Brian P

    2012-08-30

    AbstractPurposeThere is increasing evidence that neurodevelopmental differences in people with Fragile X syndrome (FraX) may be explained by differences in glutamatergic metabolism. Premutation carriers of FraX were originally considered to be unaffected although several recent reports demonstrate neuroanatomical, cognitive, and emotional differences from controls. However there are few studies on brain metabolism in premutation carriers of FraX.MethodsWe used proton magnetic resonance spectroscopy to compare neuronal integrity of a number of brain metabolites including N-Acetyl Aspartate, Creatine + Phosphocreatinine, Choline, myoInositol, and Glutamate containing substances (Glx) in 17 male premutation carriers of FraX and 16 male healthy control individuals.ResultsThere was no significant between-group difference in the concentration of any measured brain metabolites. However there was a differential increase in N-acetyl aspartate with aging in premutation FraX individuals compared to controls.ConclusionsThis is the first 1 H-MRS study to examine premutation FraX individuals. Although we demonstrated no difference in the concentration of any of the metabolites examined between the groups, this may be due to the large age ranges included in the two samples. The differential increase in NAA levels with aging may reflect an abnormal synaptic pruning process.

  14. Proton magnetic resonance spectroscopy: normal findings in the cerebellar hemisphere in childhood

    International Nuclear Information System (INIS)

    Costa, Maria Olivia R.; Lacerda, Maria Teresa C.; Garcia Otaduy, Maria C.; Cerri, Giovanni Guido; Costa Leite, Claudia de

    2002-01-01

    The cerebellar hemispheres (CER) are different from the supratentorial white and gray matter embryologically, in cytoarchitecture, and probably in metabolic activity. Proton magnetic resonance spectroscopy ( 1 H MRS) can provide a noninvasive biochemical analysis of this region.Objective. To study, with 1 H MRS, metabolite concentrations in CER as a function of age and compare these metabolic data with those of parietoccipital white matter (PO WM) in healthy children.Materials and methods. Using single-voxel 1 H MRS, we studied 37 volunteers (3-18 years) with normal MRI scans of the brain. 1 H MRS was performed using the PRESS technique in CER and PO WM. The NAA/Cr, Cho/Cr, NAA/H 2 O, Cr/H 2 O, and Cho/H 2 O ratios were analyzed as a function of age. Metabolic data from these regions were compared.Results. The NAA/Cr ratio tended to increase with age in CER. Mean NAA/Cr and Cho/Cr ratios were found to be lower in CER than in PO WM. Mean NAA/H 2 O, Cr/H 2 O, and Cho/H 2 O ratios in CER were higher than in the PO WM.Conclusion. Our data confirm the regional variations between CER and PO WM metabolite ratios, and demonstrate a tendency of age-dependent change of the NAA/Cr ratio in CER. The creatine concentration was significantly higher in the cerebellum than in the PO WM. (orig.)

  15. Proton magnetic spectroscopic imaging of the child's brain: the response of tumors to treatment

    International Nuclear Information System (INIS)

    Tzika, A.A.; Young Poussaint, T.; Astrakas, L.G.; Barnes, P.D.; Goumnerova, L.; Scott, R.M.; Black, P.McL.; Anthony, D.C.; Billett, A.L.; Tarbell, N.J.

    2001-01-01

    Our aim was to determine and/or predict response to treatment of brain tumors in children using proton magnetic resonance spectroscopic imaging (MRSI). We studied 24 patients aged 10 months to 24 years, using MRI and point-resolved spectroscopy (PRESS; TR 2000 TE 65 ms) with volume preselection and phase-encoding in two dimensions on a 1.5 T imager. Multiple logistic regression was used to establish independent predictors of active tumor growth. Biologically vital cell metabolites, such as N-acetyl aspartate and choline-containing compounds (Cho), were significantly different between tumor and control tissues (P<0.001). The eight brain tumors which responded to radiation or chemotherapy, exhibited lower Cho (P=0.05), higher total creatine (tCr) (P=0.02) and lower lactate and lipid (L) (P=0.04) than16 tumors which were not treated (except by surgery) or did not respond to treatment. The only significant independent predictor of active tumor growth was tCr (P<0.01). We suggest that tCr is useful in assessing response of brain tumors to treatment. (orig.)

  16. Anterior insula GABA levels correlate with emotional aspects of empathy: a proton magnetic resonance spectroscopy study.

    Directory of Open Access Journals (Sweden)

    Qianfeng Wang

    Full Text Available Empathy is a multidimensional construct referring to the capacity to understand and share the emotional and affective states of another person. Cerebral γ-aminobutyric acid (GABA-ergic levels are associated with a variety of neurological and psychiatric disorders. However, the role of the GABA system in different dimensions of empathy has not been investigated.Thirty-two right-handed healthy volunteers took part in this study. We used proton magnetic resonance spectroscopy to determine GABA concentrations in the anterior insula (AI and the anterior cingulate cortex (ACC and to examine the relationship between the GABA concentrations and the subcomponents of empathy evaluated by the Interpersonal Reactivity Index (IRI.Pearson correlation analyses (two-tailed showed that AI GABA was significantly associated with the empathy concern score (r = 0.584, p<0.05 and the personal distress score (r = 0.538, p<0.05 but not significantly associated with other empathy subscales. No significant correlation was found between ACC GABA and empathy subscores.Left AI GABA was positively correlated with the emotional aspects of empathy. These preliminary findings call into question whether AI GABA alterations might predict empathy dysfunction in major psychiatric disorders such as autism and schizophrenia, which have been described as deficits in emotional empathic abilities.

  17. Absolute quantification of carnosine in human calf muscle by proton magnetic resonance spectroscopy

    International Nuclear Information System (INIS)

    Oezdemir, Mahir S; Reyngoudt, Harmen; Deene, Yves de; Sazak, Hakan S; Fieremans, Els; Delputte, Steven; D'Asseler, Yves; Derave, Wim; Lemahieu, Ignace; Achten, Eric

    2007-01-01

    Carnosine has been shown to be present in the skeletal muscle and in the brain of a variety of animals and humans. Despite the various physiological functions assigned to this metabolite, its exact role remains unclear. It has been suggested that carnosine plays a role in buffering in the intracellular physiological pH i range in skeletal muscle as a result of accepting hydrogen ions released in the development of fatigue during intensive exercise. It is thus postulated that the concentration of carnosine is an indicator for the extent of the buffering capacity. However, the determination of the concentration of this metabolite has only been performed by means of muscle biopsy, which is an invasive procedure. In this paper, we utilized proton magnetic resonance spectroscopy ( 1 H MRS) in order to perform absolute quantification of carnosine in vivo non-invasively. The method was verified by phantom experiments and in vivo measurements in the calf muscles of athletes and untrained volunteers. The measured mean concentrations in the soleus and the gastrocnemius muscles were found to be 2.81 ± 0.57/4.8 ± 1.59 mM (mean ± SD) for athletes and 2.58 ± 0.65/3.3 ± 0.32 mM for untrained volunteers, respectively. These values are in agreement with previously reported biopsy-based results. Our results suggest that 1 H MRS can provide an alternative method for non-invasively determining carnosine concentration in human calf muscle in vivo

  18. Proton magnetic resonance spectroscopy in children with fetal alcohol spectrum disorders

    International Nuclear Information System (INIS)

    Goncalves, Rita de Cassia Ferreira; Vasconcelos, Marcio Moacyr; Faleiros, Leticia Oliveira; Brito, Adriana Rocha; Werner Junior, Jairo; Herdy, Gesmar Volga Haddad

    2009-01-01

    To analyze the metabolic constitution of brain areas through proton magnetic resonance spectroscopy in children affected with fetal alcohol spectrum disorder compared with normal children. Method: The sample of this case-control study included eight boys with epidemiologic history of in utero exposure to alcohol (median age 13.6±3.8 years) who were diagnosed with fetal alcohol spectrum disorder, and eight controls (median age 12.1±3,4 years). An 8 cm 3 single voxel approach was used, with echo time 30 ms, repetition time 1500 ms, and 128 acquisitions in a 1.5T scanner, and four brain areas were analyzed: anterior cingulate, left frontal lobe, left striatum, and left cerebellar hemisphere. Peaks and ratios of metabolites N-acetylaspartate, choline, creatine, and myo-inositol were measured. Results: Children with fetal alcohol spectrum disorder showed a decrease in choline/creatine ratio (p=0.020) in left striatum and an increase in myo-inositol/creatine ratio (p=0.048) in left cerebellum compared with controls. There was no statistically significant difference in all peaks and ratios from the anterior cingulate and frontal lobe between the two groups. Conclusion: This study found evidence that the left striatum and left cerebellum are affected by intrauterine exposure to alcohol. Additional studies with larger samples are necessary to expand our knowledge of the effects of fetal exposure to alcohol. (author)

  19. Antisickling activity evaluation of 4 aromatic aldehydes using proton magnetic relaxation

    International Nuclear Information System (INIS)

    Falcon Dieguez, J.E.; Grisel del Toro Garcia; Yamirka Alonso Geli; Lores Guevara, M.A.

    2006-12-01

    The formation of a Shiff base aduct hemoglobin-aromatic aldehyde, has been reported as inhibitor of the hemoglobin S polymerization. Using the Proton Magnetic Resonance methodology, the polymerization kinetics can be studied and the delay time can be determined. Our studies in vitro show the inhibitor effect of the isovanillin, o-vanillin, m-hydroxybenzaldehyde and the p-hydroxybenzaldehyde, using molar ratio (hemoglobin S/compound) 1:1, 1:4 and 1:8. The td increment (expressed in percents) obtained for each one of the molar ratio was the following: isovanillin: 34±6% (1:1), 68±16% (1:4), ovanillin: 26±10% (1:1), 63±20% (1:4), m-hydroxybelzaldehyde: 16±4% (1:1), 44±12% (1:4) and the phydroxybenzaldehyde: 10±3% (1:1), 32±8% (1:4). In the case of 1:8, the characteristic kinetics curve was not obtained. At the used concentrations, hemolytic activity was not found on the red blood cell. These results confirm the antisickling activity of these aromatic aldehydes, for a technique different to that reported in literature that also allows the quantification of concentration effect. The same ones will facilitate the study of the therapeutic usefulness of these compounds in the sickle cell anemia treatment. (author)

  20. Amide Proton Transfer (APT) MR imaging and Magnetization Transfer (MT) MR imaging of pediatric brain development

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Hong; Kang, Huiying; Peng, Yun [Beijing Children' s Hospital, Capital Medical University, Imaging Center, Department of Radiology, Beijing (China); Zhao, Xuna [Philips Healthcare, Beijing (China); Jiang, Shanshan; Zhang, Yi; Zhou, Jinyuan [Johns Hopkins University, Division of MR Research, Department of Radiology, Baltimore, MD (United States)

    2016-10-15

    To quantify the brain maturation process during childhood using combined amide proton transfer (APT) and conventional magnetization transfer (MT) imaging at 3 Tesla. Eighty-two neurodevelopmentally normal children (44 males and 38 females; age range, 2-190 months) were imaged using an APT/MT imaging protocol with multiple saturation frequency offsets. The APT-weighted (APTW) and MT ratio (MTR) signals were quantitatively analyzed in multiple brain areas. Age-related changes in MTR and APTW were evaluated with a non-linear regression analysis. The APTW signals followed a decreasing exponential curve with age in all brain regions measured (R{sup 2} = 0.7-0.8 for the corpus callosum, frontal and occipital white matter, and centrum semiovale). The most significant changes appeared within the first year. At maturation, larger decreases in APTW and lower APTW values were found in the white matter. On the contrary, the MTR signals followed an increasing exponential curve with age in the same brain regions measured, with the most significant changes appearing within the initial 2 years. There was an inverse correlation between the MTR and APTW signal intensities during brain maturation. Together with MT imaging, protein-based APT imaging can provide additional information in assessing brain myelination in the paediatric population. (orig.)

  1. Measurement of the free neutron-proton analyzing power and spin transfer parameters in the charge exchange region at 790 MeV

    International Nuclear Information System (INIS)

    Ransome, R.D.

    1981-07-01

    The free neutron-proton analyzing power and the spin transfer parameters (K/sub NN/, K/sub SS/, K/sub SL/, and K/sub LL/) were measured at the Los Alamos Meson Physics Facility at 790 MeV between 165 0 and 180 0 center of mass. A 40% polarized neutron beam incident on a liquid hydrogen target was used. The recoil protons were momentum analyzed with a magnetic spectrometer to isolate elastic scatters. A large solid angle carbon polarimeter was used to measure the proton polarization. The measurements are the first at this energy and are in basic agreement with pre-existing phase shift solutions. The proton-carbon analyzing power was measured between 500 and 750 MeV. An empirical fit to the proton-carbon analyzing power between 100 and 750 MeV was done

  2. Vector analyzing power in elastic electron-proton scattering

    International Nuclear Information System (INIS)

    Diaconescu, L.; Ramsey-Musolf, M.J.

    2004-01-01

    We compute the vector analyzing power (VAP) for the elastic scattering of transversely polarized electrons from protons at low energies using an effective theory of electrons, protons, and photons. We study all contributions through second order in E/M, where E and M are the electron energy and nucleon mass, respectively. The leading-order VAP arises from the imaginary part of the interference of one- and two-photon exchange amplitudes. Subleading contributions are generated by the nucleon magnetic moment and charge radius as well as recoil corrections to the leading-order amplitude. Working to O(E/M) 2 , we obtain a prediction for A n that is free of unknown parameters and that agrees with the recent measurement of the VAP in backward angle ep scattering

  3. An Expansion Method to Unfold Proton Recoil Spectra

    Energy Technology Data Exchange (ETDEWEB)

    Kockum, J

    1970-07-01

    A method is given to obtain a good estimate of the input neutron spectrum from a pulse-height distribution measured with proportional counters filled with a hydrogenous gas. The method consists of expanding the sought estimate as a product of two functions where one is obtained by differentiating the pulse-height distribution and the other is a power series of the neutron energy. The coefficients of this series are determined by a least-squares fit of the calculated pulse-height distribution to the measured one. The method has been tested on pulse-height distributions obtained by calculations from a realistic neutron spectrum and response functions for a spherical counter 3. 94 cm in diameter and filled with 7 atm. of methane and 1 atm. of hydrogen, respectively. In the former case it is possible with the method described, to unfold pulse-height distributions up to a neutron energy of about 3 MeV to within 10 % of the input spectrum. The differentiating procedure included in the method ensures that all spectral details not smoothed out by the finite resolution of the counter, are kept in the spectrum estimate. A realistic estimate of the statistical uncertainty of each neutron spectrum value is given. Some of the possible systematical errors caused by uncertainties in input data have been investigated.

  4. Search for magnetic monopoles with the MoEDAL prototype trapping detector in 8 TeV proton-proton collisions at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Acharya, B. [Theoretical Particle Physics & Cosmology Group, Physics Dept., King’s College London (United Kingdom); International Centre for Theoretical Physics, Trieste (Italy); Alexandre, J. [Theoretical Particle Physics & Cosmology Group, Physics Dept., King’s College London (United Kingdom); Bendtz, K. [Physics Department, Stockholm University, Stockholm (Sweden); Benes, P. [IEAP, Czech Technical University in Prague (Czech Republic); Collaboration: The MoEDAL collaboration; and others

    2016-08-10

    The MoEDAL experiment is designed to search for magnetic monopoles and other highly-ionising particles produced in high-energy collisions at the LHC. The largely passive MoEDAL detector, deployed at Interaction Point 8 on the LHC ring, relies on two dedicated direct detection techniques. The first technique is based on stacks of nuclear-track detectors with surface area ∼18 m{sup 2}, sensitive to particle ionisation exceeding a high threshold. These detectors are analysed offline by optical scanning microscopes. The second technique is based on the trapping of charged particles in an array of roughly 800 kg of aluminium samples. These samples are monitored offline for the presence of trapped magnetic charge at a remote superconducting magnetometer facility. We present here the results of a search for magnetic monopoles using a 160 kg prototype MoEDAL trapping detector exposed to 8 TeV proton-proton collisions at the LHC, for an integrated luminosity of 0.75 fb{sup −1}. No magnetic charge exceeding 0.5g{sub D} (where g{sub D} is the Dirac magnetic charge) is measured in any of the exposed samples, allowing limits to be placed on monopole production in the mass range 100 GeV≤m≤ 3500 GeV. Model-independent cross-section limits are presented in fiducial regions of monopole energy and direction for 1g{sub D}≤|g|≤6g{sub D}, and model-dependent cross-section limits are obtained for Drell-Yan pair production of spin-1/2 and spin-0 monopoles for 1g{sub D}≤|g|≤4g{sub D}. Under the assumption of Drell-Yan cross sections, mass limits are derived for |g|=2g{sub D} and |g|=3g{sub D} for the first time at the LHC, surpassing the results from previous collider experiments.

  5. Studies of (p, γ) reactions with the Daresbury Recoil Separator at ORNL'S HRIBF

    International Nuclear Information System (INIS)

    Fitzgerald, R.; Abbotoy, E.; Bardayan, D.W.; Blackmon, J.C.; Champagne, A.E.; Chen, A.A.; Greife, U.; Hill, D.W.; James, A.N.; Kozub, R.L.; Lewis, T.A.; Livesay, R.; Ma, Z.; Mahan, S.L.; McConnell, J.W.; Milner, W.T.; Moazen, B.H.; Parker, P.D.; Pierce, D.E.; Roettger, M.E.; Sahin, L.; Shapira, D.; Smith, M.S.; Strieder, F.; Swartz, K.B.; Thomas, J.S.; Visser, D.W.

    2005-01-01

    The fusion of protons with radioactive nuclei is important in stellar explosions such as novae and X-ray bursts and for the production of neutrinos in the sun. The Daresbury Recoil Separator and a windowless gas target system have been installed at ORNL's Holifield Radioactive Ion Beam Facility (HRIBF) for measurements of proton capture reactions in inverse kinematics with radioactive ion beams. The performance of the system has been characterized with a number of experiments using stable ion beams. We report on results from these commissioning measurements and plans for measurements of the 1 H( 17 F, 18 Ne) and 1 H( 7 Be, 8 B) reactions

  6. Alteration of the magnitude of the proton magnetic moment in nuclear magnetons in connection with the changes in the atomic mass values

    Energy Technology Data Exchange (ETDEWEB)

    Mamyrin, B.A.; Aruev, N.N.; Alekseenko, S.A.

    1983-06-01

    In connection with the revision of the table values of the atomic masses and the forthcoming coordination of the values of the fundamental physical constants, the result of measurement of the proton magnetic moment in nuclear Magnetons obtained in 1971 is re-examined by taking into account recent data. With the atomic masses recognized in 1982 the proton magnetic moment expressed in nuclear magnetons without a correction for diamagnetic screening of the proton in a water molecule is found to be ..mu..sub(p)'/..mu..sub(n)=2.7927729+-0.0000012 (4.3x10/sup -5/%).

  7. Proton nuclear magnetic resonance study of water + t-butyl alcohol ...

    African Journals Online (AJOL)

    The water proton resonance initially shifts to higher frequencies (low fields) as the cosolvent is added to water, and the shift to higher frequency is strongly temperature dependent, the effect being greatly enhanced at lower temperatures. As the proportion of cosolvent increases the hydroxyl proton signals in the water + ...

  8. A proton nuclear magnetic resonance-based metabonomics study of metabolic profiling in immunoglobulin a nephropathy

    International Nuclear Information System (INIS)

    Sui, Weiguo; Che, Wenti; Guimai, Zuo; Chen, Jiejing; Li, Liping; Li, Wuxian; Dai, Yong

    2012-01-01

    Objectives: Immunoglobulin A nephropathy is the most common cause of chronic renal failure among primary glomerulonephritis patients. The ability to diagnose immunoglobulin A nephropathy remains poor. However, renal biopsy is an inconvenient, invasive, and painful examination, and no reliable biomarkers have been developed for use in routine patient evaluations. The aims of the present study were to identify immunoglobulin A nephropathy patients, to identify useful biomarkers of immunoglobulin A nephropathy and to establish a human immunoglobulin A nephropathy metabolic profile. Methods: Serum samples were collected from immunoglobulin A nephropathy patients who were not using immunosuppressants. A pilot study was undertaken to determine disease-specific metabolite biomarker profiles in three groups: healthy controls (N = 23), low-risk patients in whom immunoglobulin A nephropathy was confirmed as grades I-II by renal biopsy (N = 23), and high-risk patients with nephropathies of grades IV-V (N = 12). Serum samples were analyzed using proton nuclear magnetic resonance spectroscopy and by applying multivariate pattern recognition analysis for disease classification. Results: Compared with the healthy controls, both the low-risk and high-risk patients had higher levels of phenylalanine, myo-inositol, lactate, L6 lipids ( CH-CH 2 -CH = O), L5 lipids (-CH 2 -C = O), and L3 lipids (-CH 2 -CH 2 -C = O) as well as lower levels of β-glucose, α-glucose, valine, tyrosine, phosphocholine, lysine, isoleucine, glycerolphosphocholine, glycine, glutamine, glutamate, alanine, acetate, 3-hydroxybutyrate, and 1-methylhistidine. Conclusions: These metabolites investigated in this study may serve as potential biomarkers of immunoglobulin A nephropathy. Point scoring of pattern recognition analysis was able to distinguish immunoglobulin A nephropathy patients from healthy controls. However, there were no obvious differences between the low-risk and high-risk groups in our research

  9. Localised proton magnetic resonance spectroscopy of the brain after perinatal hypoxia: a preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Chateil, J.F. [Service de Radiologie A, Hopital Pellegrin, Bordeaux (France)]|[Unite de Radiopediatrie, Hopital Pellegrin, Bordeaux (France); Quesson, B.; Thiaudiere, E.; Delalande, C.; Canioni, P. [Resonance Magnetique des Systemes Biologiques, CNRS, Bordeaux (France); Brun, M.; Diard, F. [Service de Radiologie A, Hopital Pellegrin, Bordeaux (France); Sarlangue, J.; Billeaud, C. [Service de Neonatalogie, Hopital Pellegrin, Bordeaux (France)

    1999-03-01

    Objectives. Perinatal hypoxic ischaemic injury is a significant cause of neurodevelopmental impairment. The aim of this study was to evaluate localised proton magnetic resonance spectroscopy ({sup 1}H-MRS) after birth asphyxia. Materials and methods. Thirty newborn infants suspected of having perinatal asphyxia (Apgar score < 3) were studied. The mean gestational age was 37 weeks, mean age at the MR examination was 18 days and mean weight was 2.9 kg. A 1.5-T unit was used for imaging and spectroscopy. None of the babies had mechanically assisted ventilation. No sedation was used. Axial T1-weighted and T2-weighted images were obtained. {sup 1}H-MRS was recorded in a single voxel, localised in white matter, using a STEAM sequence. Results. Image quality was good in 25 of 30 babies. {sup 1}H-MRS was performed in 19 of 30 subjects, with adequate quality in 16. Choline, creatine/phosphocreatine and N-acetylaspartate peaks and peak-area ratios were analysed. Lactate was detected in four infants. The N-acetylaspartate/choline ratio was lower in infants with an impaired neurological outcome, but the difference was not statistically significant. Conclusions. This study suggests that {sup 1}H-MRS may be useful for assessing cerebral metabolism in the neonate. A raised lactate level and decreased N-acetylaspartate/choline ratio may be predictive of a poor outcome. However, in our experience this method is limited by the difficulty in performing the examination during the first hours after birth in critically ill babies, the problems related to use of a monovoxel sequence, the dispersion of the ratios and the lack of determination of the absolute concentration of the metabolites. (orig.) With 3 figs., 2 tabs., 20 refs.

  10. Proton magnetic resonance spectroscopy and single photon emission CT in patients with olivopontocerebellar atrophy

    International Nuclear Information System (INIS)

    Ikuta, Naomi

    1998-01-01

    Using proton magnetic resonance spectroscopy ( 1 H-MRS) and single photon emission CT (SPECT), the cerebellum of patients with olivopontocerebellar atrophy (OPCA) and of age-matched control subjects was studied. A spectrum was collected from a 27 cm 3 (3 x 3 x 3 cm) voxel in the cerebellum containing white and gray matters in order to measure the distribution and relative signal intensities of N-acetylaspartate (NAA), creatine (Cre) and choline (Cho). In the cerebellum of the patients with OPCA, mean NAA/Cre ratios for OPCA patients were significantly decreased compared with normal control subjects (OPCA, 1.01±0.247; controls, 1.526±0.144: p<0.001). Mean NAA/Cho ratios for OPCA patients were slightly decreased (OPCA, 1.285±0.228; controls 1.702±0.469: p<0.06). Cho/Cre ratios valued in the cerebellum of OPCA patients were not significantly different from those in normal controls (OPCA, 0.793±0.186; controls, 0.946±0.219). The ratio of RI count in the cerebellum to that in the occipital lobe was significantly decreased in OPCA patients (OPCA, 0.947±0.096; controls, 1.06±0.063: p<0.01). Cerebellar signs were assessed including gait ataxia, limb ataxia, dysarthria, saccadic pursuit, and nystagmus separately or in combination. In patients with more severe ataxic gait and dysarthria, MRS revealed slightly lowered NAA/Cre ratio. There was no significant correlation between NAA/Cre ratio and severity of other clinical signs. The MRS and SPECT findings give a confirmative evidence of hypofunction in cerebellum of patients with OPCA. (author)

  11. Proton magnetic resonance spectroscopy in patients with early stages of amyotrophic lateral sclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Sivak, Stefan [Comenius University, Clinic of Neurology, Jessenius Faculty of Medicine, Martin (Slovakia); Jessenius Medical Faculty, Clinic of Neurology, Martin (Slovakia); Bittsansky, Michal; Dobrota, Dusan [Comenius University, Department of Medical Biochemistry, Jessenius Faculty of Medicine, Martin (Slovakia); Kurca, Egon; Turcanova-Koprusakova, Monika; Grofik, Milan; Nosal, Vladimir [Comenius University, Clinic of Neurology, Jessenius Faculty of Medicine, Martin (Slovakia); Polacek, Hubert [Comenius University, Clinic of Radiodiagnostics, Jessenius Faculty of Medicine, Martin (Slovakia)

    2010-12-15

    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder primarily affecting upper and lower motor neurons. Due to relative fast progression of the disease, early diagnosis is essential. Proton magnetic resonance spectroscopy ({sup 1}H-MRS) is used for objectivization of upper motor neuron (UMN) lesions. The aim of this study was to assess the use of {sup 1}H-MRS in the early stages of ALS. Eleven patients with clinically definite (n = 2), probable (n = 7), and probable laboratory-supported (n = 2) diagnosis of ALS with disease duration of less than 14 months were studied. Control group consists of 11 sex- and age-matched healthy subjects. All subjects underwent assessment of functional disability using revised ALS Functional Rating Scale (ALSFRS-R) and single-voxel {sup 1}H-MRS examination of both precentral gyri, pons, medulla oblongata, and occipital lobe. Spectra were evaluated with LCModel software. The mean disease duration was 6.5 {+-} 3.5 months. The median ALSFRS-R was 42. Significant decrease between patient and control groups was found in the NAA/Cre ratio in the left and right precentral gyri (p = 0.008, p = 0.040). Other metabolite ratios in other areas did not show significant differences. Total ALSFRS-R score weakly positively correlated with NAA/Cre ratio in the left precentral gyrus (p = 0.047). {sup 1}H-MRS is sensitive to detect metabolic changes caused by neurodegeneration processes during ALS and can be used for detection of UMN dysfunction. These MRS changes in the early stages of ALS are most prominent in motor cortex. (orig.)

  12. Proton magnetic resonance spectroscopy in patients with early stages of amyotrophic lateral sclerosis

    International Nuclear Information System (INIS)

    Sivak, Stefan; Bittsansky, Michal; Dobrota, Dusan; Kurca, Egon; Turcanova-Koprusakova, Monika; Grofik, Milan; Nosal, Vladimir; Polacek, Hubert

    2010-01-01

    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder primarily affecting upper and lower motor neurons. Due to relative fast progression of the disease, early diagnosis is essential. Proton magnetic resonance spectroscopy ( 1 H-MRS) is used for objectivization of upper motor neuron (UMN) lesions. The aim of this study was to assess the use of 1 H-MRS in the early stages of ALS. Eleven patients with clinically definite (n = 2), probable (n = 7), and probable laboratory-supported (n = 2) diagnosis of ALS with disease duration of less than 14 months were studied. Control group consists of 11 sex- and age-matched healthy subjects. All subjects underwent assessment of functional disability using revised ALS Functional Rating Scale (ALSFRS-R) and single-voxel 1 H-MRS examination of both precentral gyri, pons, medulla oblongata, and occipital lobe. Spectra were evaluated with LCModel software. The mean disease duration was 6.5 ± 3.5 months. The median ALSFRS-R was 42. Significant decrease between patient and control groups was found in the NAA/Cre ratio in the left and right precentral gyri (p = 0.008, p = 0.040). Other metabolite ratios in other areas did not show significant differences. Total ALSFRS-R score weakly positively correlated with NAA/Cre ratio in the left precentral gyrus (p = 0.047). 1 H-MRS is sensitive to detect metabolic changes caused by neurodegeneration processes during ALS and can be used for detection of UMN dysfunction. These MRS changes in the early stages of ALS are most prominent in motor cortex. (orig.)

  13. Phosphorus-31 and proton magnetic resonance spectroscopy of the medial temporal region in schizophrenic patients

    International Nuclear Information System (INIS)

    Yamada, Koichiro

    1996-01-01

    Phosphorus-31 magnetic resonance spectroscopy (MRS) was performed 22 schizophrenic patients and in 22 healthy volunteers. Psychiatric symptoms were estimated on the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Negative Symptoms (SANS) and the Scale for the Assessment of Positive Symptoms (SAPS). The spectra were quantified for phosphomonoesters (PME), inorganic orthophosphate (Pi), phosphodiesters (PDE), phosphocreatine (Pcr) and the γ, α and β phosphates of 5'-adenosine triphosphate (ATP) by peak area measurements. Proton MRS was performed in 15 schizophrenic patients and in 15 healthy volunteers. Psychiatric symptoms were estimated on the Positive and Negative Syndrome Scale (PANSS) and the SANS. The spectra of N-acetylates (NA), choline-containing compounds (Cho) and creatine-phosphocreatine (Cr) were quantified. The patients showed an increase in the % PDE and a decrease in the % β-ATP in the left temporal region. Positive correlations were found between the % PDE and the subscale of positive symptoms on the BPRS and the total score of SAPS. The % β-ATP correlated negatively with the total score on SAPS. The NA/Cho and NA/Cr ratios were significantly lower in patients than in normal subjects. The Cho/Cr ratio was higher in the patient group. The age at onset of illness correlated positively with the NA/Cho and NA/Cr ratios. No significant correlations were observed between the ratios of metabolites and the scores of PANSS and SANS. There were no significant associations between the mole percentages and the ratios and the daily doses of neuroleptics and anticholinergics. These findings suggest that the disturbed membrane phospholipid and high-energy phosphate metabolism in the left medial temporal region may be one of the pathophysiologies of neuroleptic-resistant positive symptoms in schizophrenia and these abnormalities may be related to neuronal loss and/or neuronal dysfunction in this region. (H.O.)

  14. A proton nuclear magnetic resonance-based metabonomics study of metabolic profiling in immunoglobulin a nephropathy

    Energy Technology Data Exchange (ETDEWEB)

    Sui, Weiguo; Che, Wenti; Guimai, Zuo; Chen, Jiejing [181st Hospital Guangxi, Central Laboratory, Laboratory of Metabolic Diseases Research, Guangxi Province (China); Li, Liping [Guangxi Normal University, The Life Science College, Guangxi Province (China); Li, Wuxian [Key Laboratory of Laboratory Medical Diagnostics of Education Ministry, Chongqiong Medical University, Chongqing (China); Dai, Yong [Clinical Medical Research Center, the Second Clinical Medical College of Jinan University (Shenzhen People' s Hospital), Shenzhen, Guangdong Province (China)

    2012-07-01

    Objectives: Immunoglobulin A nephropathy is the most common cause of chronic renal failure among primary glomerulonephritis patients. The ability to diagnose immunoglobulin A nephropathy remains poor. However, renal biopsy is an inconvenient, invasive, and painful examination, and no reliable biomarkers have been developed for use in routine patient evaluations. The aims of the present study were to identify immunoglobulin A nephropathy patients, to identify useful biomarkers of immunoglobulin A nephropathy and to establish a human immunoglobulin A nephropathy metabolic profile. Methods: Serum samples were collected from immunoglobulin A nephropathy patients who were not using immunosuppressants. A pilot study was undertaken to determine disease-specific metabolite biomarker profiles in three groups: healthy controls (N = 23), low-risk patients in whom immunoglobulin A nephropathy was confirmed as grades I-II by renal biopsy (N = 23), and high-risk patients with nephropathies of grades IV-V (N = 12). Serum samples were analyzed using proton nuclear magnetic resonance spectroscopy and by applying multivariate pattern recognition analysis for disease classification. Results: Compared with the healthy controls, both the low-risk and high-risk patients had higher levels of phenylalanine, myo-inositol, lactate, L6 lipids ( CH-CH{sub 2}-CH = O), L5 lipids (-CH{sub 2}-C = O), and L3 lipids (-CH{sub 2}-CH{sub 2}-C = O) as well as lower levels of {beta}-glucose, {alpha}-glucose, valine, tyrosine, phosphocholine, lysine, isoleucine, glycerolphosphocholine, glycine, glutamine, glutamate, alanine, acetate, 3-hydroxybutyrate, and 1-methylhistidine. Conclusions: These metabolites investigated in this study may serve as potential biomarkers of immunoglobulin A nephropathy. Point scoring of pattern recognition analysis was able to distinguish immunoglobulin A nephropathy patients from healthy controls. However, there were no obvious differences between the low-risk and high

  15. Frontal lobe proton magnetic-resonance spectroscopy in Graves' disease: a pilot study

    Energy Technology Data Exchange (ETDEWEB)

    Khushu, S.; Gupta, A.; Sankar, R.; Tripathi, R.P.; Bhatara, V.S. [NMR Research Center and Department of Endocrinology, Institute of Nuclear Medicine and Allied Sciences, Lucknow Marg, Delhi 110054 (India)

    1998-08-01

    Patients with hyperthyroidism may show impaired performance on several neuropsychological tests that require complex visual discrimination, conceptualization, mental flexibility or organization. These neurocognitive impairments appear to be consistent with prefrontal lobe dysfunction. This pilot study was undertaken to characterize the metabolite profile in the right prefrontal cortex in six patients with untreated Graves' disease by using in vivo proton magnetic-resonance spectroscopy ({sup 1}H-MRS). For comparison, {sup 1}H-MRS was also carried out inseven healthy controls. The choline/creatine (Cho/Cr) and N-acetyl aspartate/creatine (Naa/Cr) ratios were determined. Cho/Cr ratios of the hyperthyroid patients were significantly lower than that of controls (means{+-}SD=0.61{+-}0.09 vs. 0.90{+-}0.18, p=.05). The two groups did not differ in their Naa/Cr ratios. Follow-up data after antithyroid treatment were available in three patients: Cho/Cr ratios were higher after treatment (euthyroidism) than before treatment (1.06 vs. 0.55; 0.82 vs. 0.54; 1.15 vs. 0.76). Tentatively, these preliminary data are most consistent with reversible reductions in the concentrations of choline-containing compounds (especially glycerophosphocholine and phosphocholine) in the prefrontal area during hyperthyroidism. However, these findings await confirmation by a definitive study with a larger sample size. A possible explanation of the findings is an altered brain cholinergic-adrenergic balance in hyperthyroidism. (Copyright (c) 1998 Elsevier Science B.V., Amsterdam. All rights reserved.)

  16. Absolute quantitative analysis for sorbic acid in processed foods using proton nuclear magnetic resonance spectroscopy

    International Nuclear Information System (INIS)

    Ohtsuki, Takashi; Sato, Kyoko; Sugimoto, Naoki; Akiyama, Hiroshi; Kawamura, Yoko

    2012-01-01

    Highlights: ► A method using qHNMR was applied and validated to determine SA in processed foods. ► This method has good accuracy, precision, selectiveness, and linearity. ► The proposed method is more rapid and simple than the conventional method. ► We found that the proposed method is reliable for the accurate determination of SA. ► This method can be used for the monitoring of SA in processed foods. - Abstract: An analytical method using solvent extraction and quantitative proton nuclear magnetic resonance (qHNMR) spectroscopy was applied and validated for the absolute quantification of sorbic acid (SA) in processed foods. The proposed method showed good linearity. The recoveries for samples spiked at the maximum usage level specified for food in Japan and at 0.13 g kg −1 (beverage: 0.013 g kg −1 ) were larger than 80%, whereas those for samples spiked at 0.063 g kg −1 (beverage: 0.0063 g kg −1 ) were between 56.9 and 83.5%. The limit of quantification was 0.063 g kg −1 for foods (and 0.0063 g kg −1 for beverages containing Lactobacillus species). Analysis of the SA content of commercial processed foods revealed quantities equal to or greater than those measured using conventional steam-distillation extraction and high-performance liquid chromatography quantification. The proposed method was rapid, simple, accurate, and precise, and provided International System of Units traceability without the need for authentic analyte standards. It could therefore be used as an alternative to the quantification of SA in processed foods using conventional method.

  17. Absolute quantitative analysis for sorbic acid in processed foods using proton nuclear magnetic resonance spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Ohtsuki, Takashi, E-mail: ohtsuki@nihs.go.jp [National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501 (Japan); Sato, Kyoko; Sugimoto, Naoki; Akiyama, Hiroshi; Kawamura, Yoko [National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501 (Japan)

    2012-07-13

    Highlights: Black-Right-Pointing-Pointer A method using qHNMR was applied and validated to determine SA in processed foods. Black-Right-Pointing-Pointer This method has good accuracy, precision, selectiveness, and linearity. Black-Right-Pointing-Pointer The proposed method is more rapid and simple than the conventional method. Black-Right-Pointing-Pointer We found that the proposed method is reliable for the accurate determination of SA. Black-Right-Pointing-Pointer This method can be used for the monitoring of SA in processed foods. - Abstract: An analytical method using solvent extraction and quantitative proton nuclear magnetic resonance (qHNMR) spectroscopy was applied and validated for the absolute quantification of sorbic acid (SA) in processed foods. The proposed method showed good linearity. The recoveries for samples spiked at the maximum usage level specified for food in Japan and at 0.13 g kg{sup -1} (beverage: 0.013 g kg{sup -1}) were larger than 80%, whereas those for samples spiked at 0.063 g kg{sup -1} (beverage: 0.0063 g kg{sup -1}) were between 56.9 and 83.5%. The limit of quantification was 0.063 g kg{sup -1} for foods (and 0.0063 g kg{sup -1} for beverages containing Lactobacillus species). Analysis of the SA content of commercial processed foods revealed quantities equal to or greater than those measured using conventional steam-distillation extraction and high-performance liquid chromatography quantification. The proposed method was rapid, simple, accurate, and precise, and provided International System of Units traceability without the need for authentic analyte standards. It could therefore be used as an alternative to the quantification of SA in processed foods using conventional method.

  18. 100 group displacement cross sections from RECOIL data base

    International Nuclear Information System (INIS)

    Gopalakrishnan, V.

    1995-01-01

    Displacement cross sections in 100 neutron energy groups were calculated from the RECOIL data base using the RECOIL program, for use in DPA (Displacement Per Atom) calculations for FBTR and PFBR materials. 100 group displacement cross sections were calculated using RECOIL-Data Base and RECOIL Program. Modifications were made in the data base to reduce space requirement, and in the program for easy handling on a PC. 2 refs

  19. Laterally and longitudinally dispersive recoil mass separators

    International Nuclear Information System (INIS)

    Wollnik, H.

    1987-01-01

    Principles of laterally dispersive and time-of-flight mass separators are outlined. Special emphasis is given to separators for very energetic recoils for which electrostatic fields would be technologically impossible. The principle of energy isochronous time-of-flight mass separators is shown to be applicable to storage rings. (orig.)

  20. INS gas-filled recoil isotope separator

    International Nuclear Information System (INIS)

    Miyatake, M.; Nomura, T.; Kawakami, H.

    1986-09-01

    The characteristics and performance of a small sized gas-filled recoil isotope separator recently made at INS are described. The total efficiency and the ΔBρ/Bρ values have been measured using low velocity 16 O, 40 Ar and 68 As ions and found to be 10 and 5 %, respectively. The Z-dependence of the mean charge is discussed. (author)

  1. Electrochemical etching amplification of low-let recoil particle tracks in polymers for fast neutron dosimetry

    International Nuclear Information System (INIS)

    Sohrabi, M.; Morgan, K.Z.

    1975-11-01

    An electrochemical etching method for the amplification of fast-neutron-induced recoil particle tracks in polymers was investigated. The technique gave superior results over those obtained by conventional etching methods especially when polycarbonate foils were used for recoil particle track amplification. Electrochemical etching systems capable of multi-foil processing were designed and constructed to demonstrate the feasibility of the techniques for large-scale neutron dosimetry. Electrochemical etching parameters were studied including the nature or type of the polymer foil used, foil thickness and its effect on etching time, the applied voltage and its frequency, the chemical composition, concentration, and temperature of the etchant, distance and angle between the electrodes, and the type of particles such as recoil particles including protons. Recoil particle track density, mean track diameter, and optical density as functions of the mentioned parameters were determined. Each parameter was found to have a distinct effect on the etching results in terms of the measured responses. Several new characteristics of this fast neutron dosimetry method were studied especially for personnel dosimetry using various radiation sources such as nuclear reactors, medical cyclotrons, and isotopic neutron sources. The dose range, neutron energy dependence, directional response, fading characteristics, neutron threshold energy, etc. were investigated

  2. Cerebrospinal fluid metabolic profiles in multiple sclerosis and degenerative dementias obtained by high resolution proton magnetic resonance spectroscopy

    International Nuclear Information System (INIS)

    Vion-Dury, J.; Confort-Gouny, S.; Maillet, S.; Cozzone, P.J.; Nicoli, F.; Gastaut, J.L.

    1996-01-01

    We have analyzed the cerebrospinal fluid (CSF) of 19 patients with multiple sclerosis (MS), 12 patients with degenerative dementia and 17 control patients using in vitro high resolution proton magnetic resonance spectroscopy (MRS) at 400 MHz. The CSF metabolic profile is slightly modified in MS patients (increased lactate and fructose concentrations, decreased creatinine and phenylalanine concentrations) and is not correlated with the intensity of the intrathecal inflammation. Proton MRS of CSF does not differentiate relapsing-remitting MS and primary progressive MS. We have not detected any specific abnormal resonance in native or lyophilized CSF. The CSF metabolic profile of demented patients is much more altered (increased concentration of lactate, pyruvate, alanine, lysine, valine, leucine-isoleucine, tyrosine, glutamine) and is in agreement with a brain oxidative metabolism impairment as already described in Alzheimer's disease. Unassigned abnormal but non specific or constant resonances have been detected on MR spectra of demented patients. CSF inositol concentration is also increased in the CSF of patients with Alzheimer's disease. In vitro high resolution proton MRS of the CSF constitutes a new and original way to explore CSF for the differential and/or early diagnosis of dementias, as a complement to in vivo proton cerebral MRS. (authors). 22 refs., 4 figs., 2 tabs

  3. Cerebrospinal fluid metabolic profiles in multiple sclerosis and degenerative dementias obtained by high resolution proton magnetic resonance spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Vion-Dury, J.; Confort-Gouny, S.; Maillet, S.; Cozzone, P.J. [Centre Hospitalier Universitaire de la Timone, 13 - Marseille (France); Nicoli, F. [Centre Hospitalier Universitaire de la Timone, 13 - Marseille (France)]|[Hopital Sainte-Marguerite, 13 - Marseille (France); Gastaut, J.L. [Hopital Sainte-Marguerite, 13 - Marseille (France)

    1996-07-01

    We have analyzed the cerebrospinal fluid (CSF) of 19 patients with multiple sclerosis (MS), 12 patients with degenerative dementia and 17 control patients using in vitro high resolution proton magnetic resonance spectroscopy (MRS) at 400 MHz. The CSF metabolic profile is slightly modified in MS patients (increased lactate and fructose concentrations, decreased creatinine and phenylalanine concentrations) and is not correlated with the intensity of the intrathecal inflammation. Proton MRS of CSF does not differentiate relapsing-remitting MS and primary progressive MS. We have not detected any specific abnormal resonance in native or lyophilized CSF. The CSF metabolic profile of demented patients is much more altered (increased concentration of lactate, pyruvate, alanine, lysine, valine, leucine-isoleucine, tyrosine, glutamine) and is in agreement with a brain oxidative metabolism impairment as already described in Alzheimer`s disease. Unassigned abnormal but non specific or constant resonances have been detected on MR spectra of demented patients. CSF inositol concentration is also increased in the CSF of patients with Alzheimer`s disease. In vitro high resolution proton MRS of the CSF constitutes a new and original way to explore CSF for the differential and/or early diagnosis of dementias, as a complement to in vivo proton cerebral MRS. (authors). 22 refs., 4 figs., 2 tabs.

  4. MO-G-18C-07: Improving T2 Determination and Quantification of Lipid Methylene Protons in Proton Magnetic Resonance Spectroscopy at 3 T

    Energy Technology Data Exchange (ETDEWEB)

    Breitkreutz, D. [of Oncology, University of Alberta, Edmonton, AB (Canada); Fallone, B. G.; Yahya, A. [of Oncology, University of Alberta, Edmonton, AB (Canada); Department of Medical Physics, Cross Cancer Institute, Edmonton, AB (Canada)

    2014-06-15

    Purpose: To improve proton magnetic resonance spectroscopy (MRS) transverse relaxation (T{sub 2}) determination and quantification of lipid methylene chain (1.3 ppm) protons by rewinding their J-coupling evolution. Methods: MRS experiments were performed on four lipid phantoms, namely, almond, corn, sunflower and oleic acid, using a 3 T Philips MRI scanner with a transmit/receive birdcage head coil. Two PRESS (Point RESolved Spectroscopy) pulse sequences were used. The first PRESS sequence employed standard bandwidth (BW) (∼550 Hz) RF (radiofrequency) refocussing pulses, while the second used refocussing pulses of narrow BW (∼50 Hz) designed to rewind J-coupling evolution of the methylene protons in the voxel of interest. Signal was acquired with each sequence from a 5×5×5 mm{sup 3} voxel, with a repetition time (TR) of 3000 ms, and with echo times (TE) of 100 to 200 ms in steps of 20 ms. 2048 sample points were measured with a 2000 Hz sampling bandwidth. Additionally, 30 mm outer volume suppression slabs were used to suppress signal outside the voxel of interest. The frequency of the RF pulses was set to that of the methylene resonance. Methylene peak areas were calculated and fitted in MATLAB to a monexponentially decaying function of the form M{sub 0}exp(-TE/T{sub 2}), where M{sub 0} is the extrapolated area when TE = 0 ms and yields a measure of concentration. Results: The determined values of M{sub 0} and T{sub 2} increased for all fatty acids when using the PRESS sequence with narrow BW refocussing pulses. M{sub 0} and T{sub 2} values increased by an average amount (over all the phantoms) of 31% and 14%, respectively. Conclusion: This investigation has demonstrated that J-coupling interactions of lipid methylene protons causes non-negligible signal losses which, if not accounted for, Result in underestimations of their levels and T{sub 2} values when performing MRS measurements. Funded by the Natural Sciences and Engineering Research Council of Canada

  5. Study of the magnetic characteristics of ferrites with a view to their application in a proton synchrotron

    International Nuclear Information System (INIS)

    Nguyen, K.C.

    1966-10-01

    In this report magnetic properties of some Ni Zn ferrites available in France are investigated for the purpose of their use in accelerating cavities of proton synchrotron. An attempt is made to measure permeability and quality factor of ferrite versus various physical parameters such as frequency F, the induction B, the magnetic bias field Hp and the temperature, the investigation ranges being: F ≤ 40 Mc/s; B ≤ 10 -2 Tesla; Hp ≤ 5000 AT/m; T ≤ 100 C. The measurements were carried out with the one hand, conventional impedance bridge (Q-meter, RX-meter) and on the other hand, with resonating method using an inductive ferrite loaded cavity in parallel with an external capacity. The latter method is of particular interest for the measurements in function of induction and magnetic bias field. (author) [fr

  6. Duchenne muscular dystrophy carriers. Proton spin-lattice relaxation times of skeletal muscles on magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Matsumura, K.; Nakano, I. (Shimoshizu National Hospital, Chiba (Japan). Dept. of Neurology); Fukuda, N.; Ikehira, H.; Tateno, Y. (National Inst. of Radiological Sciences, Chiba (Japan). Div. of Clinical Research); Aoki, Y. (National Inst. of Radiological Sciences, Chiba (Japan))

    1989-11-01

    By means of magnetic resonance imaging (MRI), the proton spin-lattice relaxation times (T1 values) of the skeletal muscles were measured in Duchenne muscular dystrophy (DMD) carriers and normal controls. The bound water fraction (BWF) was calculated from the T1 values obtained, according to the fast proton diffusion model. In the DMD carriers, T1 values of the gluteus maximus and quadriceps femoris muscles were significantly higher, and BWFs of these muscles were significantly lower than in normal control. Degenerative muscular changes accompanied by interstitial edema were presumed responsible for this abnormality. No correlation was observed between the muscle T1 and serum creatine kinase values. The present study showed that MRI could be a useful method for studying the dynamic state of water in both normal and pathological skeletal muscles. Its possible utility for DMD carrier detection was discussed briefly. (orig.).

  7. Model for bremsstrahlung emission accompanying interactions between protons and nuclei from low energies up to intermediate energies: Role of magnetic emission

    Science.gov (United States)

    Maydanyuk, Sergei P.

    2012-07-01

    A model of the bremsstrahlung emission which accompanies proton decay and collisions of protons off nuclei in the low- to intermediate-energy region has been developed. This model includes spin formalism, a potential approach for describing the interaction between protons and nuclei, and an emission that includes a component of the magnetic emission (defined on the basis of the Pauli equation). For the problem of bremsstrahlung during proton decay the role of magnetic emission is studied by using such a model. For the 146Tm nucleus the following has been studied: (1) How much does the magnetic emission change the full bremsstrahlung spectrum? (2) At which angle is the magnetic emission the most intensive relative to the electric emission? (3) Is there some spatial region where the magnetic emission increases strongly relative to the electric emission? (4) How intensive is the magnetic emission in the tunneling region? (5) Which is the maximal probability? Which value does it equal to at the zero-energy limit of the emitted photons? It is demonstrated that the model is able to describe well enough experimental data of bremsstrahlung emission which accompanies collisions of protons off 9C, 64Cu, and 107Ag nuclei at an incident energy of Tlab=72 MeV (at a photon energy up to 60 MeV) and off 9Be, 12C, and 208Pb nuclei at an incident energy of Tlab=140 MeV (at a photon energy up to 120 MeV).

  8. Ionization and scintillation of nuclear recoils in gaseous xenon

    Energy Technology Data Exchange (ETDEWEB)

    Renner, J., E-mail: jrenner@lbl.gov [Lawrence Berkeley National Laboratory (LBNL), 1 Cyclotron Road, Berkeley, CA 94720 (United States); Department of Physics, University of California, Berkeley, CA 94720 (United States); Gehman, V.M.; Goldschmidt, A.; Matis, H.S.; Miller, T.; Nakajima, Y.; Nygren, D.; Oliveira, C.A.B.; Shuman, D. [Lawrence Berkeley National Laboratory (LBNL), 1 Cyclotron Road, Berkeley, CA 94720 (United States); Álvarez, V. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, 46980 Paterna, Valencia (Spain); Borges, F.I.G. [Departamento de Fisica, Universidade de Coimbra, Rua Larga, 3004-516 Coimbra (Portugal); Cárcel, S. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, 46980 Paterna, Valencia (Spain); Castel, J.; Cebrián, S. [Laboratorio de Física Nuclear y Astropartículas, Universidad de Zaragoza, Calle Pedro Cerbuna 12, 50009 Zaragoza (Spain); Cervera, A. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, 46980 Paterna, Valencia (Spain); Conde, C.A.N. [Departamento de Fisica, Universidade de Coimbra, Rua Larga, 3004-516 Coimbra (Portugal); and others

    2015-09-01

    Ionization and scintillation produced by nuclear recoils in gaseous xenon at approximately 14 bar have been simultaneously observed in an electroluminescent time projection chamber. Neutrons from radioisotope α-Be neutron sources were used to induce xenon nuclear recoils, and the observed recoil spectra were compared to a detailed Monte Carlo employing estimated ionization and scintillation yields for nuclear recoils. The ability to discriminate between electronic and nuclear recoils using the ratio of ionization to primary scintillation is demonstrated. These results encourage further investigation on the use of xenon in the gas phase as a detector medium in dark matter direct detection experiments.

  9. Proton beam transport experiments with pulsed high-field magnets at the Dresden laser acceleration source Draco

    Energy Technology Data Exchange (ETDEWEB)

    Kroll, Florian; Schramm, Ulrich [Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany); Technische Universitaet Dresden, Dresden (Germany); Kraft, Stephan; Metzkes, Josefine; Schlenvoigt, Hans-Peter; Zeil, Karl [Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany)

    2016-07-01

    Compact laser-driven ion accelerators are a potential alternative to large and expensive conventional accelerators. High-power short-pulse lasers, impinging on e.g. thin metal foils, enable multi-MeV ion acceleration on μm length and fs to ps time scale. The generated ion bunches (typically protons) show unique beam properties, like ultra-high pulse dose. Nevertheless, laser accelerators still require substantial development in reliable beam generation and transport. Recently developed pulsed magnets meet the demands of laser acceleration and open up new research opportunities: We present a pulsed solenoid for effective collection and focusing of laser-accelerated protons that acts as link between fundamental research and application. The solenoid is powered by a capacitor-based pulse generator and can reach a maximum magnetic field of 20 T. It was installed in the target chamber of the Draco laser at HZDR. The transported beam was detected by means of radiochromic film, scintillator and Thomson parabola spectrometer. We present the characterization of the solenoid with regard to future application in radiobiological irradiation studies. Furthermore, a detailed comparison to previous experiments with a similar magnet at the PHELIX laser at GSI, Darmstadt is provided.

  10. Nuclear Magnetic Resonance Spectroscopy Applications: Proton NMR In Biological Objects Subjected To Magic Angle Spinning

    International Nuclear Information System (INIS)

    Wind, Robert A.; Hu, Jian Zhi

    2005-01-01

    Proton NMR in Biological Objects Submitted to Magic Angle Spinning, In Encyclopedia of Analytical Science, Second Edition (Paul J. Worsfold, Alan Townshend and Colin F. Poole, eds.), Elsevier, Oxford 6:333-342. Published January 1, 2005. Proposal Number 10896

  11. Monitoring of organic contaminants in sediments using low field proton nuclear magnetic resonance

    Science.gov (United States)

    Zhang, Chi; Rupert, Yuri

    2016-04-01

    The effective monitoring of soils and groundwater contaminated with organic compounds is an important goal of many environmental restoration efforts. Recent geophysical methods such as electrical resistivity, complex conductivity, and ground penetrating radar have been successfully applied to characterize organic contaminants in the subsurface and to monitor remediation process both in laboratory and in field. Low field proton nuclear magnetic resonance (NMR) is a geophysical tool sensitive to the molecular-scale physical and chemical environment of hydrogen-bearing fluids in geological materials and shows promise as a novel method for monitoring contaminant remediation. This laboratory research focuses on measurements on synthetic samples to determine the sensitivity of NMR to the presence of organic contaminants and improve understanding of relationships between NMR observables, hydrological properties of the sediments, and amount and state of contaminants in porous media. Toluene, a light non-aqueous phase liquid (LNAPL) has been selected as a representative organic contaminant. Three types of porous media (pure silica sands, montmorillonite clay, and various sand-clay mixtures with different sand/clay ratios) were prepared as synthetic sediments. NMR relaxation time (T2) and diffusion-relaxation (D - T2) correlation measurements were performed in each sediment saturated with water and toluene mixed fluid at assorted concentrations (0% toluene and 100% water, 1% toluene and 99% water, 5% toluene and 95% water, 25% toluene and 75% water, and 100% toluene and 0% water) to 1) understand the effect of different porous media on the NMR responses in each fluid mixture, 2) investigate the role of clay content on T2 relaxation of each fluid, 3) quantify the amount hydrocarbons in the presence of water in each sediment, and 4) resolve hydrocarbons from water in D - T2 map. Relationships between the compositions of porous media, hydrocarbon concentration, and hydraulic

  12. Novel use of proton magnetic resonance spectroscopy (1HMRS to non-invasively assess placental metabolism.

    Directory of Open Access Journals (Sweden)

    Fiona C Denison

    Full Text Available Placental insufficiency is a major cause of antepartum stillbirth and fetal growth restriction (FGR. In affected pregnancies, delivery is expedited when the risks of ongoing pregnancy outweigh those of prematurity. Current tests are unable to assess placental function and determine optimal timing for delivery. An accurate, non-invasive test that clearly defines the failing placenta would address a major unmet clinical need. Proton magnetic resonance spectroscopy ((1H MRS can be used to assess the metabolic profile of tissue in-vivo. In FGR pregnancies, a reduction in N-acetylaspartate (NAA/choline ratio and detection of lactate methyl are emerging as biomarkers of impaired neuronal metabolism and fetal hypoxia, respectively. However, fetal brain hypoxia is a late and sometimes fatal event in placental compromise, limiting clinical utility of brain (1H MRS to prevent stillbirth. We hypothesised that abnormal placental (1H MRS may be an earlier biomarker of intrauterine hypoxia, affording the opportunity to optimise timing of delivery in at-risk fetuses.We recruited three women with severe placental insufficiency/FGR and three matched controls. Using a 3T MR system and a combination of phased-array coils, a 20×20×40 mm(1H MRS voxel was selected along the 'long-axis' of the placenta with saturation bands placed around the voxel to prevent contaminant signals. A significant choline peak (choline/lipid ratio 1.35-1.79 was detected in all healthy placentae. In contrast, in pregnancies complicated by FGR, the choline/lipid ratio was ≤0.02 in all placentae, despite preservation of the lipid peak (p<0.001.This novel proof-of-concept study suggests that in severe placental insufficiency/FGR, the observed 60-fold reduction in the choline/lipid ratio by (1H MRS may represent an early biomarker of critical placental insufficiency. Further studies will determine performance of this test and the potential role of 1H-MRS in the in-vivo assessment of

  13. Listing of 502 Times When the Ulysses Magnetic Fields Instrument Observed Waves Due to Newborn Interstellar Pickup Protons

    International Nuclear Information System (INIS)

    Cannon, Bradford E.; Smith, Charles W.; Isenberg, Philip A.; Vasquez, Bernard J.; Joyce, Colin J.; Murphy, Neil; Nuno, Raquel G.

    2017-01-01

    In two earlier publications we analyzed 502 intervals of magnetic waves excited by newborn interstellar pickup protons that were observed by the Ulysses spacecraft. Due to the considerable effort required in identifying these events, we provide a list of the times for the 502 wave event intervals previously identified. In the process, we provide a brief description of how the waves were found and what their properties are. We also remind the reader of the conditions that permit the waves to reach observable levels and explain why the waves are not seen more often.

  14. Listing of 502 Times When the Ulysses Magnetic Fields Instrument Observed Waves Due to Newborn Interstellar Pickup Protons

    Energy Technology Data Exchange (ETDEWEB)

    Cannon, Bradford E. [Physics Department, Florida State University, Tallahassee, Florida (United States); Smith, Charles W.; Isenberg, Philip A.; Vasquez, Bernard J.; Joyce, Colin J. [Physics Department and Space Science Center, Institute for the Study of Earth, Oceans, and Space, University of New Hampshire, Durham, New Hampshire (United States); Murphy, Neil [Jet Propulsion Laboratory, Mail Stop 180-600, 4800 Oak Grove Drive, Pasadena, California (United States); Nuno, Raquel G., E-mail: bc13h@my.fsu.edu, E-mail: Charles.Smith@unh.edu, E-mail: Phil.Isenberg@unh.edu, E-mail: Bernie.Vasquez@unh.edu, E-mail: Colin.Joyce@unh.edu, E-mail: Neil.Murphy@jpl.nasa.gov, E-mail: rgnuno@ucla.edu [Department of Earth, Planetary, and Space Sciences, University of California, Los Angeles, Los Angeles, CA (United States)

    2017-05-01

    In two earlier publications we analyzed 502 intervals of magnetic waves excited by newborn interstellar pickup protons that were observed by the Ulysses spacecraft. Due to the considerable effort required in identifying these events, we provide a list of the times for the 502 wave event intervals previously identified. In the process, we provide a brief description of how the waves were found and what their properties are. We also remind the reader of the conditions that permit the waves to reach observable levels and explain why the waves are not seen more often.

  15. Envelope model for passive magnetic focusing of an intense proton or ion beam propagating through thin foils

    Directory of Open Access Journals (Sweden)

    Steven M. Lund

    2013-04-01

    Full Text Available Ion beams (including protons with low emittance and high space-charge intensity can be propagated with normal incidence through a sequence of thin metallic foils separated by vacuum gaps of order the characteristic transverse beam extent to transport/collimate the beam or to focus it to a small transverse spot. Energetic ions have sufficient range to pass through a significant number of thin foils with little energy loss or scattering. The foils reduce the (defocusing radial electric self-field of the beam while not altering the (focusing azimuthal magnetic self-field of the beam, thereby allowing passive self-beam focusing if the magnetic field is sufficiently strong relative to the residual electric field. Here we present an envelope model developed to predict the strength of this passive (beam generated focusing effect under a number of simplifying assumptions including relatively long pulse duration. The envelope model provides a simple criterion for the necessary foil spacing for net focusing and clearly illustrates system focusing properties for either beam collimation (such as injecting a laser-produced proton beam into an accelerator or for magnetic pinch focusing to a small transverse spot (for beam driven heating of materials. An illustrative example is worked for an idealization of a recently performed laser-produced proton-beam experiment to provide guidance on possible beam focusing and collimation systems. It is found that foils spaced on the order of the characteristic transverse beam size desired can be employed and that envelope divergence of the initial beam entering the foil lens must be suppressed to limit the total number of foils required to practical values for pinch focusing. Relatively modest proton-beam current at 10 MeV kinetic energy can clearly demonstrate strong magnetic pinch focusing achieving a transverse rms extent similar to the foil spacing (20–50  μm gaps in beam propagation distances of tens of mm

  16. Magnetic resonance imaging and proton magnetic resonance spectroscopy of the brain in the diagnostic evaluation of developmental delay

    NARCIS (Netherlands)

    Verbruggen, Krijn T.; Meiners, Linda C.; Sijens, Paul E.; Lunsing, Roelineke J.; van Spronsen, Francjan J.; Brouwer, Oebele F.

    Aim: To assess the contribution of MRI and proton spectroscopy (1HMRS) in establishing an etiological diagnosis in children with developmental delay (DD) and to assess whether the chance of finding specific abnormalities correlates with the presence of neurological signs and/or abnormal head

  17. Self-triggering detectors for recoil nuclei

    International Nuclear Information System (INIS)

    Aleksanyan, A.S.; Asatiani, T.I.; Gasparyan, A.O.

    1975-01-01

    Hybrid α-detectors consisting of wide gap spark chambers and signal α detectors are described. The investigations have been carried out with γ-beams of Yerevan Electron Synchrotron. The possibility of using such detectors in the experiments on particle photoproduction on gas helium with the determination of the interaction point, emission angle of the recoil nucleus and its energy by means of range measurement has been shown. It has been shown that self - triggering wide gap spark chamber allows to detect and measure the range of the recoil nuclei α-particles with energies Esub(α) > or approximately (1 - 2) Mev which correspond to momentum transfers apprxomation (10 -2 - 10 -3 ) (GeV/c) 2

  18. Dama annual modulation from electron recoils

    OpenAIRE

    Foot, R.

    2018-01-01

    Plasma dark matter, which arises in dissipative dark matter models, can give rise to large annual modulation signals from keV electron recoils. Previous work has argued that the DAMA annual modulation signal might be explained in such a scenario. Detailed predictions are difficult due to the inherent complexities involved in modelling the halo plasma interactions with Earth bound dark matter. Here, we consider a simplified phenomenological model for the dark matter density and temperature nea...

  19. Experiments with recoil ions and other considerations

    Energy Technology Data Exchange (ETDEWEB)

    Cocke, C.L.

    1987-01-01

    Some opportunities in collisions physics with slow, multiply charged ions are addressed. A distinction between inner and outer shell collisions is drawn. The applicability of recoil ion sources to outer shell collision systems is discussed, with emphasis on the quality of the beam desired. An example of an inner shell collision is discussed, and the usefulness of not pushing the collision energy too low is pointed out. 13 refs., 14 figs.

  20. Hydrogen depth profiling using elastic recoil detection

    International Nuclear Information System (INIS)

    Doyle, B.L.; Peercy, P.S.

    1979-01-01

    The elastic recoil detection (ERD) analysis technique for H profiling in the near surface regions of solids is described. ERD is shown to have the capability of detecting H and its isotopes down to concentrations of approx. 0.01 at. % with a depth resolution of a few hundred angstroms. Is is demonstrated that 2.4-MeV He ions can be used successfully to profile 1 H and 2 D using this technique. 12 figures

  1. Recoil Considerations for Shoulder-Fired Weapons

    Science.gov (United States)

    2012-05-01

    than would be deduced from the force levels defined by the pressure-time curve of the cartridge. Further and just like a large-caliber weapon mounted...force. If each of the force curves over the time interval were integrated, the result should be the same as that derived from a ballistic pendulum...Kathe, E.; Dillon, R. Sonic Rarefaction Wave Low Recoil Gun; Report ARCCB-TR-2001; U.S. Army Armament Research, Development, and Engineering Center

  2. Atom location using recoil ion spectroscopy

    International Nuclear Information System (INIS)

    O'Connor, D.J.

    1985-01-01

    Low energy ion scattering (LEIS) using inert gas and alkali ions is widely used in studies of the surface atomic layer. The extreme surface sensitivity of this technique ensures that it yields both compositional and structural information on clean and adsorbate covered surfaces. Low Energy Negative recoil Spectroscopy (LENRS) has been applied to a study of oxygen on Ni(110) to gauge the sensitivity to coverage and site location

  3. Elastic recoil detection analysis of ferroelectric films

    Energy Technology Data Exchange (ETDEWEB)

    Stannard, W.B.; Johnston, P.N.; Walker, S.R.; Bubb, I.F. [Royal Melbourne Inst. of Tech., VIC (Australia); Scott, J.F. [New South Wales Univ., Kensington, NSW (Australia); Cohen, D.D.; Dytlewski, N. [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia)

    1996-12-31

    There has been considerable progress in developing SrBi{sub 2}Ta{sub 2}O{sub 9} (SBT) and Ba{sub O.7}Sr{sub O.3}TiO{sub 3} (BST) ferroelectric films for use as nonvolatile memory chips and for capacitors in dynamic random access memories (DRAMs). Ferroelectric materials have a very large dielectric constant ( {approx} 1000), approximately one hundred times greater than that of silicon dioxide. Devices made from these materials have been known to experience breakdown after a repeated voltage pulsing. It has been suggested that this is related to stoichiometric changes within the material. To accurately characterise these materials Elastic Recoil Detection Analysis (ERDA) is being developed. This technique employs a high energy heavy ion beam to eject nuclei from the target and uses a time of flight and energy dispersive (ToF-E) detector telescope to detect these nuclei. The recoil nuclei carry both energy and mass information which enables the determination of separate energy spectra for individual elements or for small groups of elements In this work ERDA employing 77 MeV {sup 127}I ions has been used to analyse Strontium Bismuth Tantalate thin films at the heavy ion recoil facility at ANSTO, Lucas Heights. 9 refs., 5 figs.

  4. Elastic recoil detection analysis of ferroelectric films

    Energy Technology Data Exchange (ETDEWEB)

    Stannard, W B; Johnston, P N; Walker, S R; Bubb, I F [Royal Melbourne Inst. of Tech., VIC (Australia); Scott, J F [New South Wales Univ., Kensington, NSW (Australia); Cohen, D D; Dytlewski, N [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia)

    1997-12-31

    There has been considerable progress in developing SrBi{sub 2}Ta{sub 2}O{sub 9} (SBT) and Ba{sub O.7}Sr{sub O.3}TiO{sub 3} (BST) ferroelectric films for use as nonvolatile memory chips and for capacitors in dynamic random access memories (DRAMs). Ferroelectric materials have a very large dielectric constant ( {approx} 1000), approximately one hundred times greater than that of silicon dioxide. Devices made from these materials have been known to experience breakdown after a repeated voltage pulsing. It has been suggested that this is related to stoichiometric changes within the material. To accurately characterise these materials Elastic Recoil Detection Analysis (ERDA) is being developed. This technique employs a high energy heavy ion beam to eject nuclei from the target and uses a time of flight and energy dispersive (ToF-E) detector telescope to detect these nuclei. The recoil nuclei carry both energy and mass information which enables the determination of separate energy spectra for individual elements or for small groups of elements In this work ERDA employing 77 MeV {sup 127}I ions has been used to analyse Strontium Bismuth Tantalate thin films at the heavy ion recoil facility at ANSTO, Lucas Heights. 9 refs., 5 figs.

  5. Proton nuclear magnetic resonance studies on bulge-containing DNA oligonucleotides from a mutational hot-spot sequence

    International Nuclear Information System (INIS)

    Woodson, S.A.; Crothers, D.M.

    1987-01-01

    A series of bulge-containing and normal double-helical synthetic oligodeoxyribonucleotides, of sequence corresponding to a frame-shift mutational hot spot in the λ C/sub I/ gene, are compared by proton magnetic resonance spectroscopy at 500 MHz. The imino proton resonances are assigned by one-dimensional nuclear Overhauser effect spectroscopy. Nonselective T 1 inversion-recovery experiments are used to determine exchangeable proton lifetimes and to compare helix stability and dynamics of the three duplexes. An extra adenosine flanking the internal G-C base pairs has a strongly localized effect on helix stability, but the destabilizing effect of an extra cytidine in a C tract is delocalized over the entire G-C run. These data lead to the conclusion that the position of the bulge migrates along the run in the fast-exchange limit on the NMR time scale. Rapid migration of the bulge defect in homopolymeric sequences may help rationalize both frame-shift mutagenesis and translational frame shifting. The authors estimate that the unfavorable free energy of a localized bulge defect is 2.9-3.2 kcal/mol, in good agreement with earlier estimates for RNA helices

  6. Effects of magnetic non-linearities on a stored proton beam and their implications for superconducting storage rings

    International Nuclear Information System (INIS)

    Cornacchia, M.; Evans, L.

    1985-06-01

    A nonlinear lens may be used to study the effect of high-order multipolar field imperfections on a stored proton beam. Such a nonlinear lens is particulary suitable to simulate field imperfections of the types encountered in coil dominated superconducting magnets. We have studied experimentally at the SPS the effect of high order (5th and 8th) single isolated resonances driven by the nonlinear lens. The width of these resonances is of the order one expects to be caused by field errors in superconducting magnets of the SSC type. The experiment shows that, in absence of tune modulation, these resonances are harmless. Slow crossings of the resonance, on the other hand, have destructive effects on the beam, much more so than fast crossings caused by synchrotron oscillations. In the design of future storage rings, sources of low-frequency tune modulation should be avoided as a way to reduce the harmful effects of high order multipolar field imperfection

  7. Proton drip-line studies at HRIBF

    International Nuclear Information System (INIS)

    Rykaczewski, K.P.; Batchelder, J.C.; Bingham, C.R.; Bryan, R.E.; Davinson, T.; Woods, P.J.; Ginter, T.N.; Hamilton, J. H.; Gross, C.J.; Grzywacz, R.; Janas, Z.; Karny, M.; MacDonald, B.D.; McConnell, J.W.; Toth, K.S.; Piechaczek, A.; Zganjar, E.F.; Szerypo, J.; Walters, W. B.

    2000-01-01

    Proton radioactivity studies performed at the Holifield Radioactive Ion Beam Facility (HFBR) within the last few years are reviewed. The discovery of five new proton radioactivities 140 Ho, 141m Ho, 145 Tm, 150m Lu and 151m Lu is presented together with a recent observation of fine structure in proton emission from 146gs,m Tm. These proton emitters were produced by means of fusion-evaporation reactions and studied with the HFBR Recoil Mass Separator and detection system based on a Double-sided Silicon Strip Detector. For 113 Cs and 151 Lu, the studies of level structure were extended beyond the proton-emitting states via the measurements with a clover array Clarion using Recoil Decay Tagging

  8. Study of the interactions of 13.8 GeV/c protons with the heavy nuclei of the emulsions exposed in magnetic fuel of 170 kgauss

    International Nuclear Information System (INIS)

    Gomez Aleixandre, J. L.

    1967-01-01

    145 stars with N h >8 produced by the interactions of 13.8 GeV/c protons with Ag and Br nuclei have been analysed. The emulsion stack was irradiated in a 170 K gauss magnetic field. Statistical results concerning the main characteristics of the different particles emitted are given and the energy balance is evaluated. The main features of both 24 GeV/c protons and 17 GeV/c π- interactions are compared with those we have found for 13.8 GeV/c protons interactions. (Author) 27 refs

  9. Complementary scattered and recoiled ion data from TOF-E heavy ion elastic recoil detection analysis

    International Nuclear Information System (INIS)

    Johnston, P.N.; El Bouanani, M.; Stannard, W.B.; Bubb, I.F.; Cohen, D.D.; Dytlewski, N.; Siegele, R.

    1998-01-01

    The advantage of Time of Flight and Energy (ToF-E) Heavy Ion Elastic Recoil Detection Analysis (HIERDA) over Rutherford Backscattering (RBS) analysis is its mass and energy dispersive capabilities. The mass resolution of ToF-E HIERDA deteriorates for very heavy elements. The limitation is related to the poor energy resolution of Si detectors for heavy ions. While the energy spectra from ToF-E HIERDA data are normally used to extract depth profiles, this work discusses the benefits of using the time spectra of both the recoiled and the scattered ions for depth profiling. The simulation of the complementary scattered and recoiled ion time spectra improves depth profiling and reduced current limitations when dealing with very heavy ions, such as Pt, Bi, Ta. (authors)

  10. Measurement of the Relaxation Rate of the Magnetization in Mn{sub 12}O{sub 12} -Acetate Using Proton NMR Echo

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Z. H. [Department of Physics and Astronomy, Ames Laboratory, Iowa State University, Ames, Iowa 50011 (United States); Lascialfari, A. [Dipartimento di Fisica ' ' A. Volta' ' e Unita' , INFM di Pavia, Via Bassi 6, 27100 Pavia, (Italy); Borsa, F. [Department of Physics and Astronomy, Ames Laboratory, Iowa State University, Ames, Iowa 50011 (United States); Dipartimento di Fisica ' ' A. Volta' ' e Unita' , INFM di Pavia, Via Bassi 6, 27100 Pavia, (Italy); Gatteschi, D. [Department of Chemistry, University of Florence, Via Maragliano 77, 50144 Firenze, (Italy)

    2000-03-27

    We present a novel method to measure the relaxation rate W of the magnetization of Mn{sub 12}O {sub 12} -acetate (Mn12) magnetic molecular cluster in its S=10 ground state at low T . It is based on the observation of an exponential growth in time of the proton NMR signal during the thermal equilibration of the magnetization of the molecules. We can explain the novel effect with a simple model which relates the intensity of the proton echo signal to the microscopic reversal of the magnetization of each individual Mn12 molecule during the equilibration process. The method should find wide application in the study of magnetic molecular clusters in off-equilibrium conditions. (c) 2000 The American Physical Society.

  11. Measurement of the analysing power of elastic proton-proton scattering at 582 MeV

    International Nuclear Information System (INIS)

    Berdoz, A.; Favier, B.; Foroughi, F.; Weddigen, C.

    1984-01-01

    The authors have measured the analysing power of elastic proton-proton scattering at 582 MeV for 14 angles from 20 to 80 0 CM. The angular range was limited to >20 0 by the energy loss of the recoil protons. The experiment was performed at the PM1 beam line at SIN. A beam intensity of about 10 8 particles s -1 was used. (Auth.)

  12. Exclusive {rho}{sup 0} production measured with the HERMES recoil detector

    Energy Technology Data Exchange (ETDEWEB)

    Perez Benito, Roberto Francisco

    2010-12-15

    The Hermes experiment (HERa MEasurement of Spin) at Desy was designed to study the spin structure of the nucleon in semi-inclusive deep inelastic scattering. The internal structure of the nucleon has been investigated in detail and it has been measured that the intrinsic quark spin contribution is only about 30% of the total spin of the nucleon. A formalism to describe the internal structure of the nucleon called Generalised Patron Distributions (GPDs) was developed recently to understand the fundamental structure of the nucleon. These GPDs can be accessed by the measurement of hard exclusive reactions and hard exclusive processes that can be understood in terms of GPDs. The accumulated Hermes data offer access to GPDs in different combinations of beam charge and beam and target helicity asymmetries. To improve exclusivity and to enhance the resolution of kinematic variables to study hard exclusive processes which provide access to the GPDs and hence to the orbital angular momentum of the quarks, in January 2006 a Recoil Detector was installed that surrounded the internal gas target of the Hermes experiment. The Hermes Recoil Detector consisted of three components: a silicon strip detector inside the vacuum, a scintillating fiber tracker and the photon detector. All three detectors were located inside a solenoidal magnet which provided a 1T longitudinal magnetic field. The Recoil Detector improves the selection of exclusive events by a direct measurement of the momentum and track position of the recoiling particle as well as by rejecting non-exclusive background. This detector was an ideal novel tool to combine energy and position measurements for charged particles in a momentum range of 0.1 to 1.4 GeV/c. The Recoil Detector was fully commissioned and operating. Data was taken continuously until the final Hera shutdown in July of 2007. In this thesis we report on the performance of the Recoil Detector and more specifically about the scintillating fiber tracker

  13. Controllability analysis and testing of a novel magnetorheological absorber for field gun recoil mitigation

    Science.gov (United States)

    Ouyang, Qing; Zheng, Jiajia; Li, Zhaochun; Hu, Ming; Wang, Jiong

    2016-11-01

    This paper aims to analyze the effects of combined working coils of magnetorheological (MR) absorber on the shock mitigation performance and verify the controllability of MR absorber as applied in the recoil system of a field gun. A physical scale model of the field gun is established and a long-stroke MR recoil absorber with four-stage parallel electromagnetic coils is designed to apply separate current to each stage and generate variable magnetic field distribution in the annular flow channel. Based on dynamic analysis and firing stability conditions of the field gun, ideal recoil force-stroke profiles of MR absorber at different limiting firing angles are obtained. The experimental studies are carried out on an impact test rig under different combinations of current loading: conventional unified control mode, separate control mode and timing control mode. The fullness degree index (FDI) is defined as the quantitative evaluation criterion of the controllability of MR absorber during the whole recoil motion. The results show that the force-stroke profile of the novel MR absorber can approach the ideal curve within 25 degrees of the limiting firing angle through judicious exploitation of the adjustable rheological properties of MR fluid.

  14. Development of Superconducting Combined Function Magnets for the Proton Transport Line for the J-PARC Neutrino Experiments

    CERN Document Server

    Nakamoto, Tatsushi; Anerella, Michael; Escallier, John; Fujii, T; Fukui, Yuji; Ganetis, George; Gupta, Ramesh C; Harrison, Michael; Hashiguchi, E; Higashi, Norio; Ichikawa, Atsuko; Iwamoto, Yosuke; Jain, Animesh K; Kanahara, T; Kimura, Nobuhiro; Kobayashi, Takashi; Makida, Yasuhiro; Muratore, Joseph F; Obana, Tetsuhiro; Ogitsu, T; Ohhata, Hirokatsu; Okamura, T; Orikasa, T; Parker, Brett; Sasaki, Ken Ichi; Takasaki, Minoru; Tanaka, Ken Ichi; Terashima, Akio; Tomaru, Takayuki; Wanderer, Peter; Yamamoto, Akira

    2005-01-01

    A second generation of long-baseline neutrino oscillation experiments has been proposed as one of the main projects at J-PARC jointly built by JAERI and KEK. Superconducting combined function magnets, SCFMs, will be utilized for the 50 GeV, 750 kW proton beam line for the neutrino experiment and an R&D program is in underway at KEK. The magnet is designed to provide a combined function of a dipole field of 2.6 T with a quadrupole field of 19 T/m in a coil aperture of 173.4 mm. A series of 28 magnets in the beam line will be operated DC in supercritical helium cooling below 5 K. A design feature of the SCFM is the left-right asymmetry of the coil cross section: current distributions for superimposed dipole- and quadrupole- fields are combined in a single layer coil. Another design feature is the adoption of glass-fiber reinforced phenolic plastic spacers to replace the conventional metallic collars. To evaluate this unique design, fabrication of full-scale prototype magnets is in progress at KEK and the fi...

  15. BNL alternating gradient synchrotron with four helical magnets to minimize the losses of the polarized proton beam

    Directory of Open Access Journals (Sweden)

    N. Tsoupas

    2013-04-01

    Full Text Available The principle of using multiple partial helical magnets to preserve the polarization of the proton beam during its acceleration was applied successfully to the alternating gradient synchrotron (AGS which currently operates with two partial helical magnets. In this paper we further explore this idea by using four partial helical magnets placed symmetrically in the AGS ring. This provides many advantages over the present setup of the AGS, which uses two partial helical magnets. First, the symmetric placement of the four helical magnets and their relatively lower field of operation allows for better control of the AGS optics with reduced values of the beta functions especially near beam injection and allows both the vertical and horizontal tunes to be placed within the “spin tune gap,” therefore eliminating the horizontal and vertical intrinsic spin resonances of the AGS during the acceleration cycle. Second, it provides a wider spin tune gap. Third, the vertical spin direction during beam injection and extraction is closer to vertical. Although the spin tune gap, which is created with four partial helices, can also be created with a single or two partial helices, the high field strength of a single helical magnet which is required to generate such a spin tune gap makes the use of the single helical magnet impractical, and that of the two helical magnets rather difficult. In this paper we will provide results on the spin tune and on the optics of the AGS with four partial helical magnets, and compare them with those from the present setup of the AGS that uses two partial helical magnets. Although in this paper we specifically discuss the effect of the four partial helices on the AGS, this method which can eliminate simultaneously the vertical and horizontal intrinsic spin resonances is a general method and can be applied to any medium energy synchrotron which operates in similar energy range like the AGS and provides the required space to

  16. arXiv Search for magnetic monopoles with the MoEDAL forward trapping detector in 2.11 fb$^{-1}$ of 13 TeV proton-proton collisions at the LHC

    CERN Document Server

    Acharya, B.; The MoEDAL collaboration; Baines, S.; Benes, P.; Bergmann, B.; Bernabéu, J.; Bevan, A.; Branzas, H.; Campbell, M.; Caramete, L.; Cecchini, S.; de Montigny, M.; De Roeck, A.; Ellis, J.R.; Fairbairn, M.; Felea, D.; Frank, M.; Frekers, D.; Garcia, C.; Hays, J.; Hirt, A.M.; Janecek, J.; Kim, D.-W; Kinoshita, K.; Korzenev, A.; Lacarrère, D.H.; Lee, S.C.; Leroy, C.; Levi, G.; Lionti, A.; Mamuzic, J.; Margiotta, A.; Mauri, N.; Mavromatos, N.E.; Mermod, P.; Mitsou, V.A.; Orava, R.; Ostrovskiy, I.; Parker, B.; Patrizii, L.; Păvălaş, G.E.; Pinfold, J.L.; Popa, V.; Pozzato, M.; Pospisil, S.; Rajantie, A.; Ruiz de Austri, R.; Sahnoun, Z.; Sakellariadou, M.; Santra, A.; Sarkar, S.; Semenoff, G.; Shaa, A.; Sirri, G.; Sliwa, K.; Soluk, R.; Spurio, M.; Srivastava, Y.N.; Suk, M.; Swain, J.; Tenti, M.; Togo, V.; Tuszyński, J.A.; Vento, V.; Vives, O.; Vykydal, Z.; Widom, A.; Willems, G.; Yoon, J.H.; Zgura, I.S.

    2018-07-10

    We update our previous search for trapped magnetic monopoles in LHC Run 2 using nearly six times more integrated luminosity and including additional models for the interpretation of the data. The MoEDAL forward trapping detector, comprising 222~kg of aluminium samples, was exposed to 2.11~fb$^{-1}$ of 13 TeV proton-proton collisions near the LHCb interaction point and analysed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges equal to the Dirac charge or above are excluded in all samples. The results are interpreted in Drell-Yan production models for monopoles with spins 0, 1/2 and 1: in addition to standard point-like couplings, we also consider couplings with momentum-dependent form factors. The search provides the best current laboratory constraints for monopoles with magnetic charges ranging from two to five times the Dirac charge.

  17. A Direct Search for Stable Magnetic Monopoles Produced in Positron-Proton Collisions at HERA

    CERN Document Server

    Aktas, A.; Anthonis, T.; Aplin, S.; Asmone, A.; Babaev, A.; Backovic, S.; Bahr, J.; Baghdasaryan, A.; Baranov, P.; Barrelet, E.; Bartel, W.; Baudrand, S.; Baumgartner, S.; Becker, J.; Beckingham, M.; Behnke, O.; Behrendt, O.; Belousov, A.; Berger, Ch.; Berger, N.; Bizot, J.C.; Boenig, M.-O.; Boudry, V.; Bracinik, J.; Brandt, G.; Brisson, V.; Brown, D.P.; Bruncko, D.; Busser, F.W.; Bunyatyan, A.; Buschhorn, G.; Bystritskaya, L.; Campbell, A.J.; Caron, S.; Cassol-Brunner, F.; Cerny, K.; Chekelian, V.; Contreras, J.G.; Coughlan, J.A.; Cox, B.E.; Cozzika, G.; Cvach, J.; Dainton, J.B.; Dau, W.D.; Daum, K.; Delcourt, B.; Demirchyan, R.; De Roeck, A.; Desch, K.; De Wolf, E.A.; Diaconu, C.; Dodonov, V.; Dubak, A.; Eckerlin, Guenter; Efremenko, V.; Egli, S.; Eichler, R.; Eisele, F.; Ellerbrock, M.; Elsen, E.; Erdmann, W.; Essenov, S.; Faulkner, P.J.W.; Favart, L.; Fedotov, A.; Felst, R.; Ferencei, J.; Finke, L.; Fleischer, M.; Fleischmann, P.; Fleming, Y.H.; Flucke, G.; Fomenko, A.; Foresti, I.; Formanek, J.; Franke, G.; Frising, G.; Frisson, T.; Gabathuler, E.; Garutti, E.; Gayler, J.; Gerhards, R.; Gerlich, C.; Ghazaryan, Samvel; Ginzburgskaya, S.; Glazov, A.; Glushkov, I.; Goerlich, L.; Goettlich, M.; Gogitidze, N.; Gorbounov, S.; Goyon, C.; Grab, C.; Greenshaw, T.; Gregori, M.; Grindhammer, Guenter; Gwilliam, C.; Haidt, D.; Hajduk, L.; Haller, J.; Hansson, M.; Heinzelmann, G.; Henderson, R.C.W.; Henschel, H.; Henshaw, O.; Herrera, G.; Herynek, I.; Heuer, R.-D.; Hildebrandt, M.; Hiller, K.H.; Hoffmann, D.; Horisberger, R.; Hovhannisyan, A.; Ibbotson, M.; Ismail, M.; Jacquet, M.; Janauschek, L.; Janssen, X.; Jemanov, V.; Jonsson, L.; Johnson, D.P.; Jung, H.; Kapichine, M.; Karlsson, M.; Katzy, J.; Keller, N.; Kenyon, I.R.; Kiesling, Christian M.; Klein, M.; Kleinwort, C.; Klimkovich, T.; Kluge, T.; Knies, G.; Knutsson, A.; Korbel, V.; Kostka, P.; Koutouev, R.; Krastev, K.; Kretzschmar, J.; Kropivnitskaya, A.; Kruger, K.; Kuckens, J.; Landon, M.P.J.; Lange, W.; Lastovicka, T.; Laycock, P.; Lebedev, A.; Leiner, B.; Lendermann, V.; Levonian, S.; Lindfeld, L.; Lipka, K.; List, B.; Lobodzinska, E.; Loktionova, N.; Lopez-Fernandez, R.; Lubimov, V.; Lucaci-Timoce, A.-I.; Lueders, H.; Luke, D.; Lux, T.; Lytkin, L.; Makankine, A.; Malden, N.; Malinovski, E.; Mangano, S.; Marage, P.; Marshall, R.; Martisikova, M.; Martyn, H.-U.; Maxeld, S.J.; Meer, D.; Mehta, A.; Meier, K.; Meyer, A.B.; Meyer, H.; Meyer, J.; Mikocki, S.; Milcewicz-Mika, I.; Milstead, D.; Mohamed, A.; Moreau, F.; Morozov, A.; Morris, J.V.; Mozer, Matthias Ulrich; Muller, K.; Murin, P.; Nankov, K.; Naroska, B.; Naumann, J.; Naumann, Th.; Newman, Paul R.; Niebuhr, C.; Nikiforov, A.; Nikitin, D.; Nowak, G.; Nozicka, M.; Oganezov, R.; Olivier, B.; Olsson, J.E.; Osman, S.; Ozerov, D.; Pascaud, C.; Patel, G.D.; Peez, M.; Perez, E.; Perez-Astudillo, D.; Perieanu, A.; Petrukhin, A.; Pitzl, D.; Placakyte, R.; Poschl, R.; Portheault, B.; Povh, B.; Prideaux, P.; Raicevic, N.; Reimer, P.; Rimmer, A.; Risler, C.; Rizvi, E.; Robmann, P.; Roland, B.; Roosen, R.; Rostovtsev, A.; Rurikova, Z.; Rusakov, S.; Salvaire, F.; Sankey, D.P.C.; Sauvan, E.; Schatzel, S.; Scheins, J.; Schilling, F.-P.; Schmidt, S.; Schmitt, S.; Schmitz, C.; Schoeffel, L.; Schoning, A.; Schroder, V.; Schultz-Coulon, H.-C.; Schwanenberger, C.; Sedlak, K.; Sefkow, F.; Sheviakov, I.; Shtarkov, L.N.; Sirois, Y.; Sloan, T.; Smirnov, P.; Soloviev, Y.; South, D.; Spaskov, V.; Specka, Arnd E.; Stella, B.; Stiewe, J.; Strauch, I.; Straumann, U.; Tchoulakov, V.; Thompson, Graham; Thompson, P.D.; Tomasz, F.; Traynor, D.; Truoel, Peter; Tsakov, I.; Tsipolitis, G.; Tsurin, I.; Turnau, J.; Tzamariudaki, E.; Urban, Marcel; Usik, A.; Utkin, D.; Valkar, S.; Valkarova, A.; Vallee, C.; Van Mechelen, P.; Van Remortel, N.; Vargas Trevino, A.; Vazdik, Y.; Veelken, C.; Vest, A.; Vinokurova, S.; Volchinski, V.; Vujicic, B.; Wacker, K.; Wagner, J.; Weber, G.; Weber, R.; Wegener, D.; Werner, C.; Werner, N.; Wessels, M.; Wessling, B.; Wigmore, C.; Winter, G.-G.; Wissing, Ch.; Wolf, R.; Wunsch, E.; Xella, S.; Yan, W.; Yeganov, V.; Zacek, J.; Zalesak, J.; Zhang, Z.; Zhelezov, A.; Zhokin, A.; Zimmermann, J.; Zohrabyan, H.; Zomer, F.

    2005-01-01

    A direct search has been made for magnetic monopoles produced in e^+ p collisions at a centre of mass energy of 300 GeV at HERA. The beam pipe surrounding the interaction region in 1995-1997 was investigated using a SQUID magnetometer to look for stopped magnetic monopoles. During this time an integrated luminosity of 62 pb^{-1} was delivered. No magnetic monopoles were observed and charge and mass dependent upper limits on the e^+ p production cross section are set.

  18. Recoil mixing in high-fluence ion implantation

    International Nuclear Information System (INIS)

    Littmark, U.; Hofer, W.O.

    1979-01-01

    The effect of recoil mixing on the collection and depth distribution of implanted projectiles during high-fluence irradiation of a random solid is investigated by model calculations based on a previously published transport theoretical approach to the general problem of recoil mixing. The most pronounced effects are observed in the maximum implantable amount of projectiles and in the critical fluence for saturation. Both values are significantly increased by recoil mixing. (Auth.)

  19. Heavy quark symmetry at large recoil: The case of baryons

    International Nuclear Information System (INIS)

    Koerner, J.G.; Kroll, P.

    1992-02-01

    We analyze the large recoil behaviour of heavy baryon transition form factors in semi-leptonic decays. We use a generalized Brodsky-Lepage hard scattering formalism where diquarks are considered as quasi-elementary constituents of baryons. In the limit of infinitely heavy quark masses the large recoil form factors exhibit a new model-independent heavy quark symmetry which is reminiscent but not identical to the Isgur-Wise symmetry at low recoil. (orig.)

  20. Scintillation efficiency of nuclear recoil in liquid xenon

    CERN Document Server

    Arneodo, F; Badertscher, A; Benetti, P; Bernardini, E; Bettini, A; Borio di Tigliole, A A; Brunetti, R; Bueno, A G; Calligarich, E; Campanelli, M; Carpanese, C; Cavalli, D; Cavanna, F; Cennini, P; Centro, Sandro; Cesana, A; Cline, D; De Mitri, I; Dolfini, R; Ferrari, A; Gigli-Berzolari, A; Matthey, C; Mauri, F; Mazza, D; Mazzone, L; Meng, G; Montanari, C; Nurzia, G; Otwinowski, S; Palamara, O; Pascoli, D; Pepato, Adriano; Petrera, S; Periale, L; Piano Mortari, G; Piazzoli, A; Picchi, P; Pietropaolo, F; Rancati, T; Rappoldi, A; Raselli, G L; Rebuzzi, D; Revol, Jean Pierre Charles; Rico, J; Rossella, M; Rossi, C; Rubbia, André; Rubbia, Carlo; Sala, P; Scannicchio, D A; Sergiampietri, F; Suzuki, S; Terrani, M; Tian, W; Ventura, Sandro; Vignoli, C; Wang, H; Woo, J; Xu, Z

    2000-01-01

    We present the results of a test done with a Liquid Xenon (LXe) detector for 'Dark Matter' search, exposed to a neutron beam to produce nuclear recoil events simulating those which would be generated by WIMP's elastic scattering. The aim of the experiment was to measure directly the scintillation efficiency of nuclear recoil. The nuclear recoil considered in the test was in the tens of keV range. The ratio of measured visible energy over the true recoil energy was evaluated to be about 20%, in good agreement with the theoretical predictions.

  1. Recoil ion spectroscopy with heavy ions

    International Nuclear Information System (INIS)

    Beyer, H.F.; Mann, R.

    1984-01-01

    This chapter examines the production of very high charge state ions in single ion-atom collisions. Topics considered include some aspects of highly ionized atoms, experimental approaches, the production of highly charged target ions (monoatomic targets, recoil energy distribution, molecular fragmentation, outer-shell rearrangement, lifetime measurements, a comparison of projectile-, target-, and plasma-ion stripping), and secondary collision experiments (selective electron capture, potential applications). The heavy-ion beams for the described experiments were provided by accelerators such as tandem Van de Graaff facility and the UNILAC

  2. Deuterium electrodisintegration at high recoil momentum

    International Nuclear Information System (INIS)

    Steenholen, G.

    1996-01-01

    The availability of continuous electron beams made it possible to carry out various deuterium electro-disintegration experiments in kinematical domains corresponding to a high recoil momentum. Three such experiments are discussed: 1) the left-right asymmetry with respect to the direction of the momentum transfer has been measured with good precision; 2) cross sections have been obtained in a kinematical region well above the quasi-elastic peak; 3) data have been taken in quasi-elastic kinematics that can be used to study high-momentum components in the deuterium wave function [ru

  3. Idiopathic Dilated Cardiomyopathy-proton magnetic resonance spectroscopy ( 1 H MRS ) in evaluation of myocardial metabolism. Preliminary study

    International Nuclear Information System (INIS)

    Michalak, M.; Walecki, J.; Michalak, E.; Bilinska, Z.; Ruzyllo, W.

    2002-01-01

    Primary dilated cardiomyopathy is a disease of unknown etiology and it leads to serious cardiac insufficiency. Abnormalities in cardiac metabolism can play an important role in clinical manifestation and prognosis in this group. The aim of this study was an attempt to assess cardiac metabolism using proton spectroscopy magnetic resonance method (1H MRS) and to find a relationship between cardiac metabolites and functional class NYHA and left ventricular function parameters obtained by echocardiography. Proton spectroscopy magnetic resonance was performed in 15 patients with angiographically documented idiopathic dilated cardiomyopathy and 12 healthy volunteers with voxel localized at interventricular septum area. The contents of total creatine (CR) e.g. creatine+phosphocreatine, lipids (LIP) lactates (LAC) and their ratios (CR1A, CR2A, CR1/H20, CR2/H20, CR2/CR1, LIPA, LIP/H20, LIP/CR1, LACA, LAC/H20, LAC/CR1) were examined. Patents with dilated cardiomyopathy had significantly lower level of creatine CR1A (5.04I0.88 vs. 5.94I1.15, p<0.02) and ratios LIP/H20 (4.34I2.3 vs. 15.46I20.39, p<0.04) and LIP/CR1 (24.49I21.26 vs. 34.08I13.36, p<0.05) compared to healthy volunteers. Significant correlations between NYHA functional class and ratios CR2/CR1, CR2/H20 (r=0.59 p<0.038, r=0.59 p<0.02) and between %EFLV and LIP/CR1 (r=0.64, p<0.036), as well as between the duration of the disease (CTCH) and LIP/CR1 (r=0.67, p<0.046) were found. Preliminary study with proton spectroscopy magnetic resonance (1H MRS) showed impairment cardiac metabolism in patients with idiopathic dilated cardiomyopathy. A tendency to lowered values of creatine, lipids and some ratios of these metabolites were observed in dilated cardiomyopathy group compared to healthy subjects. Our results needs further study. (author)

  4. In vivo proton magnetic resonance spectroscopy of intraventricular tumours of the brain

    International Nuclear Information System (INIS)

    Majos, Carles; Aguilera, Carles; Cos, Monica; Camins, Angels; Samitier, Alex; Castaner, Sara; Sanchez, Juan J.; Candiota, Ana P.; Delgado-Goni, Teresa; Mato, David; Acebes, Juan J.; Arus, Carles

    2009-01-01

    The aim of this study was to assess the usefulness of proton MR spectroscopy in the diagnosis of intraventricular tumours. Fifty-two intraventricular tumours pertaining to 16 different tumour types were derived from our database. All cases had single-voxel proton MR spectroscopy performed at TE at both 30 and 136 ms at 1.5 T. The Mann-Whitney U test was used to search for the most discriminative datapoints each tumour type. Characteristic trends were found for some groups: high Glx and Ala in meningiomas (p<0.001 and p<0.01, respectively), high mobile lipids in metastasis (p<0.001), high Cho in PNET (p<0.001), high mI+Gly in ependymoma (p<0.001), high NAC (p<0.01) in the absence of the normal brain parenchyma pattern in colloid cysts, and high mI/Gly and Ala in central neurocytoma. Proton MR spectroscopy provides additional metabolic information that could be useful in the diagnosis of intraventricular brain tumors. (orig.)

  5. In vivo proton magnetic resonance spectroscopy of intraventricular tumours of the brain

    Energy Technology Data Exchange (ETDEWEB)

    Majos, Carles; Aguilera, Carles [Hospital Universitari de Bellvitge, Institut de Diagnostic per la Imatge (IDI). Centre Bellvitge, L' Hospitalet de Llobregat, Barcelona (Spain); Biomateriales y Nanomedicina (CIBER-BBN), Centro de Investigacion Biomedica en Red en Bioingenieria, Cerdanyola del Valles (Spain); Cos, Monica; Camins, Angels; Samitier, Alex; Castaner, Sara; Sanchez, Juan J. [Hospital Universitari de Bellvitge, Institut de Diagnostic per la Imatge (IDI). Centre Bellvitge, L' Hospitalet de Llobregat, Barcelona (Spain); Candiota, Ana P.; Delgado-Goni, Teresa [Biomateriales y Nanomedicina (CIBER-BBN), Centro de Investigacion Biomedica en Red en Bioingenieria, Cerdanyola del Valles (Spain); Unitat de Bioquimica de Biociencies, Department de Bioquimica i Biologia Molecular, Cerdanyola del Valles (Spain); Mato, David [Hospital Universitari de Bellvitge, Department of Neurosurgery, L' Hospitalet de Llobregat, Barcelona (Spain); Acebes, Juan J. [Hospital Universitari de Bellvitge, Department of Neurosurgery, L' Hospitalet de Llobregat, Barcelona (Spain); Biomateriales y Nanomedicina (CIBER-BBN), Centro de Investigacion Biomedica en Red en Bioingenieria, Cerdanyola del Valles (Spain); Arus, Carles [Unitat de Bioquimica de Biociencies, Department de Bioquimica i Biologia Molecular, Cerdanyola del Valles (Spain); Biomateriales y Nanomedicina (CIBER-BBN), Centro de Investigacion Biomedica en Red en Bioingenieria, Cerdanyola del Valles (Spain)

    2009-08-15

    The aim of this study was to assess the usefulness of proton MR spectroscopy in the diagnosis of intraventricular tumours. Fifty-two intraventricular tumours pertaining to 16 different tumour types were derived from our database. All cases had single-voxel proton MR spectroscopy performed at TE at both 30 and 136 ms at 1.5 T. The Mann-Whitney U test was used to search for the most discriminative datapoints each tumour type. Characteristic trends were found for some groups: high Glx and Ala in meningiomas (p<0.001 and p<0.01, respectively), high mobile lipids in metastasis (p<0.001), high Cho in PNET (p<0.001), high mI+Gly in ependymoma (p<0.001), high NAC (p<0.01) in the absence of the normal brain parenchyma pattern in colloid cysts, and high mI/Gly and Ala in central neurocytoma. Proton MR spectroscopy provides additional metabolic information that could be useful in the diagnosis of intraventricular brain tumors. (orig.)

  6. ZZ RECOIL/B, Heavy Charged Particle Recoil Spectra Library for Radiation Damage Calculation

    International Nuclear Information System (INIS)

    Gabriel, T.A.; Amburgey, J.D.; Greene, N.M.

    1983-01-01

    1 - Description of problem or function: Format: GAM-II group structure; Number of groups: 104 neutron and Recoil-energy groups; Nuclides: Elements Included in Charged-Particle Recoil Data Base: Al, W, Ti, Pb, V, Mg, Cr, Be, Mn, C, Fe, Au, Co, Si, Ni, B-10, Cu, B-11, Zr, N, Nb, Li-6, Mo, Li-7, Ta (Data for Ta-181,Ta-182), O, Origin: ENDF/B-IV cross-section data. A heavy charged-particle recoil data base (primary knock-on atom (PKA) spectra) and an analysis program have been created to assist experimentalists in studying, evaluating, and correlating radiation-damage effects in different neutron environments. Since experimentally obtained controlled thermo-nuclear-reactor-type neutron spectra are not presently available, the data base can be extremely useful in relating currently obtainable radiation damage to that which is anticipated in future fusion devices. However, the usefulness of the data base is not restricted to just CTR needs. Most of the elements of interest to the radiation-damage community and all neutron reactions of any significance for these elements have been processed, using available ENDF/B-IV cross-section data, and are included in the data base. Calculated data such as primary recoil spectra, displacement rates, and gas-production rates, obtained with the data base, for different radiation environments are presented and compared with previous calculations. Primary neutrons with energies up to 20 MeV have been considered. The elements included in the data base are listed in Table I. All neutron reactions of significance for these elements (i.e., elastic, inelastic, (n,2n), (n,3n), (n,p), (n,sigma), (n,gamma), etc.,) which have cross sections available from ENDF/B-IV have been processed and placed in the data base. Table I - Elements Included in Charged-Particle Recoil Data Base: Al, W, Ti, Pb, V, Mg, Cr, Be, Mn, C, Fe, Au, Co, Si, Ni, 10 B, Cu, 11 B, Zr, N, Nb, 6 Li, Mo, 7 Li, Ta (Data for Ta 181 ,Ta 182 ), O. 2 - Method of solution: The neutron

  7. Temperature mapping using proton phase shift on a 0.3 T permanent magnet open MRI system

    International Nuclear Information System (INIS)

    Komura, Kazumi; Takahashi, Tetsuhiko; Dohi, Michiko; Harada, Junta

    2000-01-01

    Temperature mapping using proton phase shift (PPS) was evaluated for ex vivo objects. The evaluation was done on a 0.3 T permanent magnet open magnetic resonance imaging (MRI) machine, like those widely used for clinical diagnosis. Temperature maps were acquired using a gradient echo sequence (TR/TE =80/30 ms, flip angle =60 degrees, field of view =200 x 200 mm, slice thickness =8 mm, matrix size =128 x 128, data acquisition number =1, and imaging time =10.2 s). Specific first order data correction was performed to eliminate calculated temperature fluctuation due to magnetic field instability. A ham, 10 cm in diameter, was heated with a Nd: YAG laser with a wavelength of 1064 nm. The laser fiber was inserted into the ham to a depth of 3 cm. The laser power was 5, 8, or 10 W. Magnetic resonance images were taken continually during and after irradiation. Temperature maps were taken every 15 s. The maps taken during laser ablation showed color changes for the heated areas. Temperatures measured by the MRI and thermocouple had a linear relationship of r 2 =0.80. The inter-image standard deviation of the temperature maps of a non-heated object was 2.07 degrees for a 4.68 x 4.68 x 8 mm volume. This value is negligible for a monitored laser heating process since temperature rise is typically larger than 30 degrees. These results show that temperature mapping based on PPS is feasible for a 0.3 T permanent magnet open MRI system. (author)

  8. Magnetic field perturbation in proton MR imaging - A study of a contrast agent and of distortions due to metallic implants

    International Nuclear Information System (INIS)

    Olsson, M.

    1992-01-01

    Perturbations of the static magnetic field in proton MR imaging (NMR imaging, MRI, MRT) result in image distortion and/or signal loss. An investigation of a superparamagnetic contrast agent for MR imaging has been performed. Magnetite particles were embedded in biodegradable starch spheres with a diameter of one micrometer. Animal experiments showed that the agent was quickly accumulated in the reticulo-endothelial system (RES), causing a decrease in signal intensity in this region. Diffusion within the locally generated magnetic field perturbation is responsible for signal loss in spin-echo images. Furthermore, the magnetic properties of various aneurysm clips were investigated to determine which clips could be used safely in a clinical MR investigation. MR artifacts caused by the metallic clips were studied using a geometric phantom. Non-ferromagnetic clips were concluded to be safe for examinations with medium field (0.3 tesla) MR imaging systems. A comparison study between MR and CT was performed on patients harbouring intracranial, nonferromagnetic aneurysm clips. The artifacts close to the clips were equally serve for MR and CT, but at some distance, the MR images were much less affected than the CT images. Finally, a computer program capable of simulating any realistic MR imaging situation has been developed. Raw data matrices are obtained by solving the Bloch equations. Corrections for intravascular spin behaviour have been implemented together with efficient algorithms. A quantitative investigation of signal displacement and signal loss, caused by small metallic implants, has been performed by computer simulation. An exact expression for the magnetic field outside a homogeneous ellipsoid in an external magnetic field has been derived. Distortions in MR images, caused by perturbing ellipsoids of different shapes and orientations, were studied. (30 refs.) (au)

  9. Continuous monitoring of the zinc-phosphate acid-base cement setting reaction by proton nuclear magnetic relaxation

    International Nuclear Information System (INIS)

    Apih, T.; Lebar, A.; Pawlig, O.; Trettin, R.

    2001-01-01

    Proton nuclear magnetic relaxation is a well-established technique for continuous and non destructive monitoring of hydration of conventional Portland building cements. Here, we demonstrate the feasibility of nuclear magnetic resonance (NMR) monitoring of the setting reaction of zinc-phosphate acid-base dental cements, which harden in minutes as compared to days, as in the case of Portland cements. We compare the setting of cement powder (mainly, zinc oxide) prepared with clinically used aluminum-modified orthophosphoric acid solution with the setting of a model system where cement powder is mixed with pure orthophosphoric acid solution. In contrast to previously published NMR studies of setting Portland cements, where a decrease of spin-lattice relaxation time is attributed to enhanced relaxation at the growing internal surface, spin-lattice relaxation time T 1 increases during the set of clinically used zinc-phosphate cement. Comparison of these results with a detailed study of diffusion, viscosity, and magnetic-field dispersion of T 1 in pure and aluminum-modified orthophosphoric acid demonstrates that the increase of T 1 in the setting cement is connected with the increase of molecular mobility in the residual phosphoric acid solution. Although not taken into account so far, such effects may also significantly influence the relaxation times in setting Portland cements, particularly when admixtures with an effect on water viscosity are used. [copyright] 2001 American Institute of Physics

  10. Recoil 18F-chemistry in fluoroalkanes

    International Nuclear Information System (INIS)

    Linde, K.D. van der.

    1982-01-01

    This thesis describes the study of the chemical reactions of recoil 18 F-atoms in gaseous fluoromethanes and fluoroethanes. A brief survey of the organic hot atom chemistry is given in Chapter I. Chapter II deals with the experimental procedures used in this investigation. The irradiation facilities, the vapour phase radio-chromatography and the identification, including the synthesis of some fluorocarbons, are described in detail. Chapter III consists of a study on the applicability of perfluoropropene, C 3 F 6 , as scavenger for thermal 18 F-atoms and radicals. Chapters IV, V, VI and VII deal with 18 F-recoil chemistry in gaseous fluoroethanes, using H 2 S as scavenger. Chapter VIII is a short discussion on the hot 18 F-atom based production of 18 F-labeled organic compounds via decay of the intermediate 18 Ne. A target system is proposed for production of this isotope in high energy and ultra high flux particle beams, which possibly would become available in fast breeders and fusion reactors. (Auth.)

  11. Synchrotron-radiation experiments with recoil ions

    International Nuclear Information System (INIS)

    Levin, J.C.

    1989-01-01

    Studies of atoms, ions and molecules with synchrotron radiation have generally focused on measurements of properties of the electrons ejected during, or after, the photoionization process. Much can also be learned, however, about the atomic or molecular relaxation process by studies of the residual ions or molecular fragments following inner-shell photoionization. Measurements are reported of mean kinetic energies of highly charged argon, krypton, and xenon recoil ions produced by vacancy cascades following inner-shell photoionization using white and monochromatic synchrotron x radiation. Energies are much lower than for the same charge-state ions produced by charged-particle impact. The results may be applicable to design of future angle-resolved ion-atom collision experiments. Photoion charge distributions are presented and compared with other measurements and calculations. Related experiments with synchrotron-radiation produced recoil ion, including photoionization of stored ions and measurement of shakeoff in near-threshold excitation, are briefly discussed. 24 refs., 6 figs., 1 tab

  12. Investigation of proton spin relaxation in water with dispersed silicon nanoparticles for potential magnetic resonance imaging applications

    Science.gov (United States)

    Kargina, Yu. V.; Gongalsky, M. B.; Perepukhov, A. M.; Gippius, A. A.; Minnekhanov, A. A.; Zvereva, E. A.; Maximychev, A. V.; Timoshenko, V. Yu.

    2018-03-01

    Porous and nonporous silicon (Si) nanoparticles (NPs) prepared by ball-milling of electrochemically etched porous Si layers and crystalline Si wafers were studied as potential agents for enhancement of the proton spin relaxation in aqueous media. While nonporous Si NPs did not significantly influence the spin relaxation, the porous ones resulted in strong shortening of the transverse relaxation times. In order to investigate an effect of the electron spin density in porous Si NPs on the proton spin relaxation, we use thermal annealing of the NPs in vacuum or in air. The transverse relaxation rate of about 0.5 l/(g s) was achieved for microporous Si NPs, which were thermally annealing in vacuum to obtain the electron spin density of the order of 1017 g-1. The transverse relaxation rate was found to be almost proportional to the concentration of porous Si NPs in the range from 0.1 to 20 g/l. The obtained results are discussed in view of possible biomedical applications of Si NPs as contrast agents for magnetic resonance imaging.

  13. Measurements of the Backstreaming Proton IONS in the Self-Magnetic Pinch (SMP) Diode Utilizing Copper Activation Technique

    Science.gov (United States)

    Mazarakis, Michael; Cuneo, Michael; Fournier, Sean; Johnston, Mark; Kiefer, Mark; Leckbee, Joshua; Simpson, Sean; Renk, Timothy; Webb, Timothy; Bennett, Nichelle

    2016-10-01

    The results presented here were obtained with an SMP diode mounted at the front high voltage end of the 8-10-MV RITS Self-Magnetically Insulated Transmission Line (MITL) voltage adder. Our experiments had two objectives: first, to measure the contribution of the back-streaming proton currents emitted from the anode target, and second, to evaluate the energy of those ions and hence the actual Anode-Cathode (A-K) gap voltage. The accelerating voltage quoted in the literature is estimated utilizing para-potential flow theories. Thus, it is interesting to have another independent measurement of the A-K voltage. We have measured the back-streaming protons emitted from the anode and propagating through a hollow cathode tip for various diode configurations and different techniques of target cleaning treatment, namely, heating at very high temperatures with DC and pulsed current, with RF plasma cleaning, and with both plasma cleaning and heating. We have also evaluated the A-K gap voltage by energy filtering techniques. Sandia is operated by Sandia Corporation, a subsidiary of Lockheed Martin Company, for the US DOE NNSA under Contract No. DE-AC04-94AL85000.

  14. Magnetization transfer from macromolecules to water protons in murine dental tissues as revealed by 500 MHz 1H-NMR

    International Nuclear Information System (INIS)

    Nakamura, Koji; Era, Seiichi; Nagai, Naoki; Sogami, Masaru; Takasaki, Akihiko; Kato, Kazuo.

    1997-01-01

    Although much is known about magnetization transfer phenomena in biological soft tissues, little is known about those in hard tissues. Using a 500 MHz 1 H-NMR spectrometer, we studied the spin-lattice relaxation time (T 1 (H 2 O)) and the intermolecular cross-relaxation times (T IS (H 2 O)) from irradiated macromolecular protons to observed water protons in murine lower incisors (hard tissue) and compared with those in murine lens tissue (soft tissue). Mean values for the water content (%) of murine lower incisors and lens tissue were 16.02±2.39 (n=14) and 67.20±4.60 (n=15), respectively. These findings were consistent with the large different in water content between soft tissues and hard tissues. T IS (H 2 O) values obtained by f 2 -irradiation at 7.13 or -4.00 ppm showed no significant difference between lower incisors and lens tissue. Plots of 1/T IS (H 2 O) values vs. tissue dry weight (W(%)) for lower incisor tissue approximated a straight line with slope approximately equal for that obtained for lens tissue. These results suggest that the state of water in hard tissue may be similar to that in soft tissues, in spite of the significant difference in water content. Thus, saturation transfer NMR techniques such as measurement of T IS (H 2 O) values may be applicable to the study of water-macromolecule interactions in both biological soft and hard tissues. (author)

  15. Characterization of proton and neutron irradiated low resistivity p-on-n magnetic Czochralski ministrip sensors and diodes

    International Nuclear Information System (INIS)

    Pacifico, Nicola; Dolenc Kittelmann, Irena; Fahrer, Manuel; Moll, Michael; Militaru, Otilia

    2011-01-01

    Transient Current Technique (TCT) and Charge Collection Efficiency (CCE) measurements were performed on low resistivity (280Ωcm) n-bulk, p-readout magnetic Czochralski ministrip sensors and diodes. The detectors were irradiated with neutrons and 24 GeV/c protons up to a total NIEL equivalent fluence of 8×10 15 /cm 2 . The study was addressed to assess the radiation tolerance of the detectors up to fluences expected in the next generations of High Energy Physics experiments. The charge collection efficiency after irradiation was found to be much higher than for standard FZ silicon p-in-n sensors. The underlying physics of this remarkable result was investigated by performing Edge-TCT measurements on one of the neutron irradiated ministrip sensors to extract detailed informations about the field and efficiency profiles of the detector.

  16. Characterization of proton and neutron irradiated low resistivity p-on-n magnetic Czochralski ministrip sensors and diodes

    Energy Technology Data Exchange (ETDEWEB)

    Pacifico, Nicola, E-mail: nicola.pacifico@cern.ch [CERN, Geneva (Switzerland); Dolenc Kittelmann, Irena; Fahrer, Manuel; Moll, Michael [CERN, Geneva (Switzerland); Militaru, Otilia [UCL, Louvain (Belgium)

    2011-12-01

    Transient Current Technique (TCT) and Charge Collection Efficiency (CCE) measurements were performed on low resistivity (280{Omega}cm) n-bulk, p-readout magnetic Czochralski ministrip sensors and diodes. The detectors were irradiated with neutrons and 24 GeV/c protons up to a total NIEL equivalent fluence of 8 Multiplication-Sign 10{sup 15}/cm{sup 2}. The study was addressed to assess the radiation tolerance of the detectors up to fluences expected in the next generations of High Energy Physics experiments. The charge collection efficiency after irradiation was found to be much higher than for standard FZ silicon p-in-n sensors. The underlying physics of this remarkable result was investigated by performing Edge-TCT measurements on one of the neutron irradiated ministrip sensors to extract detailed informations about the field and efficiency profiles of the detector.

  17. Proton radiography of dynamic electric and magnetic fields in laser-produced high-energy-density plasmas

    International Nuclear Information System (INIS)

    Li, C. K.; Seguin, F. H.; Frenje, J. A.; Manuel, M.; Casey, D.; Sinenian, N.; Petrasso, R. D.; Amendt, P. A.; Landen, O. L.; Rygg, J. R.; Town, R. P. J.; Betti, R.; Meyerhofer, D. D.; Delettrez, J.; Knauer, J. P.; Marshall, F.; Sangster, T. C.; Smalyuk, V. A.; Soures, J. M.; Shvarts, D.

    2009-01-01

    Time-gated, monoenergetic-proton radiography provides unique measurements of the electric (E) and magnetic (B) fields produced in laser-foil interactions and during the implosion of inertial-confinement-fusion capsules. These experiments resulted in the first observations of several new and important features: (1) observations of the generation, decay dynamics, and instabilities of megagauss B fields in laser-driven planar plastic foils, (2) the observation of radial E fields inside an imploding capsule, which are initially directed inward, reverse direction during deceleration, and are likely related to the evolution of the electron pressure gradient, and (3) the observation of many radial filaments with complex electromagnetic field striations in the expanding coronal plasmas surrounding the capsule. The physics behind and implications of such observed fields are discussed.

  18. The investigations on the use of proton magnetic resonance in the quantitative analysis of organis compounds. Part 1. Review of analytical methods

    International Nuclear Information System (INIS)

    Ciercierska-Stoklosa, D.

    1976-01-01

    The review of papers on the application of proton magnetic resonance in quantitative analyisis of organic compounds in multicomponent mixtures has been presented. The applied techniques have been described and unified way of presentation of formulas used in calculations has been propsed. The information about precision, accuracy and detectability of the method and the possibility of improving of determination has been given. (author)

  19. Pattern recognition analysis of proton nuclear magnetic resonance spectra of brain tissue extracts from rats anesthetized with propofol or isoflurane.

    Directory of Open Access Journals (Sweden)

    Hiroshi Kawaguchi

    Full Text Available BACKGROUND: General anesthesia is routinely used as a surgical procedure and its safety has been endorsed by clinical outcomes; however, its effects at the molecular level have not been elucidated. General anesthetics influence glucose metabolism in the brain. However, the effects of anesthetics on brain metabolites other than those related to glucose have not been well characterized. We used a pattern recognition analysis of proton nuclear magnetic resonance spectra to visualize the changes in holistic brain metabolic phenotypes in response to the widely used intravenous anesthetic propofol and the volatile anesthetic isoflurane. METHODOLOGY/PRINCIPAL FINDINGS: Rats were randomized into five groups (n = 7 each group. Propofol and isoflurane were administered to two groups each, for 2 or 6 h. The control group received no anesthesia. Brains were removed directly after anesthesia. Hydrophilic compounds were extracted from excised whole brains and measured by proton nuclear magnetic resonance spectroscopy. All spectral data were processed and analyzed by principal component analysis for comparison of the metabolite profiles. Data were visualized by plotting principal component (PC scores. In the plots, each point represents an individual sample. The propofol and isoflurane groups were clustered separately on the plots, and this separation was especially pronounced when comparing the 6-h groups. The PC scores of the propofol group were clearly distinct from those of the control group, particularly in the 6-h group, whereas the difference in PC scores was more subtle in the isoflurane group and control groups. CONCLUSIONS/SIGNIFICANCE: The results of the present study showed that propofol and isoflurane exerted differential effects on holistic brain metabolism under anesthesia.

  20. Proton therapy device

    International Nuclear Information System (INIS)

    Tronc, D.

    1994-01-01

    The invention concerns a proton therapy device using a proton linear accelerator which produces a proton beam with high energies and intensities. The invention lies in actual fact that the proton beam which is produced by the linear accelerator is deflected from 270 deg in its plan by a deflecting magnetic device towards a patient support including a bed the longitudinal axis of which is parallel to the proton beam leaving the linear accelerator. The patient support and the deflecting device turn together around the proton beam axis while the bed stays in an horizontal position. The invention applies to radiotherapy. 6 refs., 5 figs

  1. Clinical applications of proton magnetic resonance spectroscopy of the brain; Klinische Anwendungen der Protonen-Magnetresonanzspektroskopie des Gehirns

    Energy Technology Data Exchange (ETDEWEB)

    Laubenberger, J.; Bayer, S.; Thiel, T.; Hennig, J.; Langer, M. [Radiologische Universitaetsklinik Freiburg (Germany). Abt. Roentgendiagnostik

    1998-06-01

    In spite of all the scientific advances of the past few years, proton magnetic resonance spectroscopy of the brain has not attained the status of a routine examination technique with clinically accepted indications. The method should be considered as an additional option to MR imaging for inherited and acquired encephalopathic changes as well as, in future, for localization diagnosis of epilepsies. A proton magnetic resonance spectroscopic investigation without a prior intensive clinical and imaging investigation is not useful. Above all, factors influencing metabolite distribution such as for example, serum osmolability must be known. Methodological prerequisites for the clinical application of proton resonance spectroscopy are, first of all, a high stability of the chosen technique as well as a sufficiently certain quantification of metabolites and the availability of a reference group. The use of short echo times is necessary for the quantification of glutamine and the osmolyte myo-inositol. Indications for individual cases in which clinical investigations and MR topography cannot provide sufficient certainty and spectroscopy can furnish additional information are, in addition to uses in neuropediatrics, the suspicion of Alzheimer`s dementia, HIV encephalopathy in early manifestations, and unclarified depressions of consciousness accompanying liver cirrhosis. (orig.) [Deutsch] Die Protonen-Magnetresonanzspektroskopie des Gehirns ist trotz aller wissenschaftlicher Fortschritte der letzten Jahre noch nicht zu einer Routineuntersuchung mit anerkannter klinischer Indikationsstellung geworden. Die Untersuchung muss bei angeborenen und erworbenen enzephalopathischen Veraenderungen sowie in Zukunft in der Lokalisationsdiagnostik von Epilepsien als Zusatzoption zur MR-Bildgebung erachtet werden. Eine protonenspektroskopische Untersuchung ohne ausgiebige klinische und bildgebende Basisuntersuchung ist nicht sinnvoll. Insbesondere muessen Einflussfaktoren, wie z

  2. Detector for recoil nuclei stopping in the spark chamber gas

    International Nuclear Information System (INIS)

    Aleksanyan, A.S.; Asatiani, T.L.; Ivanov, V.I.; Mkrtchyan, G.G.; Pikhtelev, R.N.

    1974-01-01

    A detector consisting of the combination of a drift and a wide gap spark chambers and designed to detect recoil nuclei stopping in the spark chamber gas is described. It is shown, that by using an appropriate discrimination the detector allows to detect reliably the recoil nuclei in the presence of intensive electron and γ-quanta beams

  3. Nuclear targets, recoil ion catchers and reaction chambers

    NARCIS (Netherlands)

    Dionisio, JS; Vieu, C; Schuck, C; Collatz, R; Meunier, R; Ledu, D; Folger, H; Lafoux, A; Lagrange, JM; Pautrat, M; Waast, B; Phillips, WR; Blunt, D; Durell, JL; Varley, BJ; Dagnall, PG; Dorning, SJ; JONES, MA; Smith, AG; Bacelar, JCS; Rzaca-Urban, T; Amzal, N; Meliani, Z; Vanhorenbeeck, J; Passoja, A; Urban, W

    1998-01-01

    The main features of nuclear targets, recoil ion catchers and reaction chambers used in nuclear spectroscopic investigations involving in-beam multi-e-gamma spectrometers are discussed. The relative importance of the F-ray background due to the accelerated ion-target and the recoil-ion-target

  4. Comparison of the Recoil of Conventional and Electromagnetic Cannon

    Directory of Open Access Journals (Sweden)

    Edward M. Schmidt

    2001-01-01

    Full Text Available The recoil from an electromagnetic (EM railgun is discussed and compared with that from conventional, propellant gas driven cannon. It is shown that, under similar launch conditions, the recoil of the EM gun is less than that of the powder gun; however, use of a muzzle brake on a powder gun can alter this relative behavior.

  5. Transportation system of recoil nucleus by helium jet

    International Nuclear Information System (INIS)

    Cabral, S.C.; Borges, A.M.; Lemos Junior, O.F.; Auler, L.T.; Silva, A.G. da

    1981-01-01

    The transportation system of recoil nucleus by helium jet, is studied. It is used a technique aiming to put in the detection area (region of low background) the recoils, produced by nuclear reactions between target and particle beams, those produced with the help of cyclotron CV-28. (E.G.) [pt

  6. 7 Tesla proton magnetic resonance spectroscopic imaging in adult X-linked adrenoleukodystrophy

    Science.gov (United States)

    Ratai, Eva; Kok, Trina; Wiggins, Christopher; Wiggins, Graham; Grant, Ellen; Gagoski, Borjan; O'Neill, Gilmore; Adalsteinsson, Elfar; Eichler, Florian

    2010-01-01

    Background Adult patients with X-linked adrenoleukodystrophy (X-ALD) remain at risk for progressive neurological deterioration. Phenotypes vary in their pathology, ranging from axonal degeneration to inflammatory demyelination. The severity of symptoms is poorly explained by conventional imaging. Objective To test the hypothesis that neurochemistry in normal appearing brain differs among adult phenotypes of X-ALD, and that neurochemical changes correlate with the severity of symptoms. Patients and Methods Using a 7 Tesla scanner we performed structural and proton MRSI in 13 adult patients with X-ALD, including 4 patients with adult cerebral ALD (ACALD), 5 with adrenomyeloneuropathy (AMN) and 4 female heterozygotes. Studies were also performed in nine healthy controls. Results Among adult X-ALD phenotypes, MI/Cr was 46% higher and Cho/Cr 21% higher in normal appearing white matter of ACALD compared to AMN (p Tesla proton MRSI reveals differences in the neurochemistry of ACALD but is unable to distinguish AMN from female heterozygotes. MI/Cr correlates with the severity of the symptoms and may be a meaningful biomarker in adult X-ALD. PMID:19001168

  7. Development of Selective Excitation Methods in Nuclear Magnetic Resonance: Investigation of Hemoglobin Oxygenation in Erythrocytes Using Proton and Phosphorus -31 Nuclear Magnetic Resonance

    Science.gov (United States)

    Fetler, Bayard Keith

    1993-01-01

    Nuclear magnetic resonance (NMR) offers a potential method for making measurements of the percent oxygenation of hemoglobin (Hb) in living tissue non-invasively. As a demonstration of the feasibility of such measurements, we measured the percent oxygenation of Hb in red blood cells (erythrocytes) using resonances in the proton-NMR (^1H-NMR) spectrum which are characteristic of oxyhemoglobin (oxy-Hb) and deoxyhemoglobin (deoxy-Hb), and are due to the unique magnetic properties of these molecules. To perform these measurements, we developed a new NMR method of selectively exciting signals in a region of interest with uniform phase and amplitude, while suppressing the signal of the water resonance. With this method, we are able to make exact calculations distinguishing between uniform phase excitation produced at large flip-angles using the non-linear properties of the Bloch equations, and uniform phase excitation produced at small flip-angles using asymmetric pulse excitation functions. We measured the percent oxygenation of three characteristic ^1H-NMR resonances of Hb: two from deoxy-Hb, originating from the N_delta H protons of histidine residue F8, which occur at different frequencies for the alpha and beta chains of Hb; and one from oxy-Hb, originating from the gamma_2 -CH_3 protons of valine residue E11. We performed experiments both on fresh erythrocytes and on erythrocytes depleted of 2,3-diphosphoglycerate (2,3-DPG), and found that oxygen is more tightly bound to Hb in the former case. In both fresh and 2,3-DPG-depleted samples, we found that: (i) from the deoxy-Hb marker resonances, there is a small but significant difference in the oxygen saturation between the alpha and beta chains; (ii) the decrease in the areas of the deoxy-Hb marker resonances correlates well with the increase in the percent oxygenation of Hb as measured optically; (iii) the area of the oxy-Hb marker resonance may be up to ~15% less than the optically measured Hb saturation. We are

  8. Lifetime measurements using the recoil distance method—achievements and perspectives

    Science.gov (United States)

    Krücken, R.

    2001-07-01

    The recoil distance method (RDM) for measuring pico-second nuclear level lifetimes and its use in nuclear structure studies is reviewed and perspectives for the future are presented. High precision measurements in the mass-130 region, studies of multi-phonon states in rare earth nuclei, the investigation of shape coexistence and the recently discovered phenomenon of "magnetic rotation" are reviewed. Prospects for lifetime measurements in exotic regions of nuclei such as the measurement of lifetimes in neutron rich nuclei populated via spontaneous and heavy-ion induced fission are discussed. Other prospects include the use of the RDM technique in conjunction with recoil separators. The relevance of these techniques for experiments with radioactive ion beams will be discussed.

  9. Selection and acquisition of data for the measurement of the spin rotation parameters in pion-proton scattering at high energies

    International Nuclear Information System (INIS)

    Raoul, Jean-Claude

    1971-01-01

    The experiment consists in measuring the polarisation of the recoil protons from elastic scattering of positive or negative pions on a polarised proton target (L. M. N.). The polarimeter consists in carbon plates alternated with wire spark chambers, The associated electronics has the following main functions: selective triggering of the spark chambers, acquisition and transcription on magnetic tape of all relevant information, continuous check of the various parts of the equipment. About one hundred scintillation counters provide information on the geometry of the pion-proton scattering. A fast logic treats these information. This logic, made of integrated circuits MECL, generates the selective trigger with a transit time of less than 150 ns, it reduces the triggering rate on background events by almost one order of magnitude. A small computer is used for acquisition and transcription of the data, and for the control of the experiment. (author) [fr

  10. D-Brane Recoil Mislays Information

    CERN Document Server

    Ellis, Jonathan Richard; Nanopoulos, Dimitri V

    1998-01-01

    We discuss the scattering of a light closed-string state off a $D$ brane, taking into account quantum recoil effects on the latter, which are described by a pair of logarithmic operators. The light-particle and $D$-brane subsystems may each be described by a world-sheet with an external source due to the interaction between them. This perturbs each subsystem away from criticality, which is compensated by dressing with a Liouville field whose zero mode we interpret as time. The resulting evolution equations for the $D$ brane and the closed string are of Fokker-Planck and modified quantum Liouville type, respectively. The apparent entropy of each subsystem increases as a result of the interaction between them, which we interpret as the loss of information resulting from non-observation of the other entangled subsystem. We speculate on the possible implications of these results for the propagation of closed strings through a dilute gas of virtual $D$ branes.

  11. Range calculations for spallation recoils in ThF4 by use of the computer code 'Marlowe'

    International Nuclear Information System (INIS)

    Westmeier, W.; Roessler, K.

    1978-12-01

    The determination of cross sections of spallation reactions requires a knowledge of the target thickness since only the products recoiling from the target are measured and their yield depends on the range. The effective target thickness is a function of the projectile's Z, A and spallation recoil energy and, thus, varies for the individual products. The computer code MARLOWE was used to evaluate energy vs. range curves in the binary collisions approximation. The program was extended to the high energy regime taking into account the stripping of electrons from the projectile and the concomitant changes in the interaction potentials especially for the inelastic part of the collisions. A complementary computer program LATTIC was developed for the parameterization of the lattice description. This code enables the application of MARLOWE to target materials with complicated crystallographic structure. Test calculations for a series of projectile/target combinations showed a reasonable agreement with experimental recoil ranges of Pd, Ag, Os and Ir isotopes from proton induced spallation in Ag, In and Pb targets, respectively. MARLOWE was then applied to calculate product ranges of the 232 Th(p,spall)X-reaction in the ployatomic system ThF 4 . The calculated energy vs. range curves enabled the evaluation of the mean spallation recoil ranges for all possible products, e.g. 170.8 μg/cm 2 for 192 Tl, 115.2 μg/cm 2 for 208 At and 37.1 μg/cm 2 for 223 Ac. (orig.)

  12. Proton magnetic resonance chemical shift imaging (1H CSI)-directed stereotactic biopsy

    International Nuclear Information System (INIS)

    Son, B.-C.; Kim, B.-C.; Kang, J.-K.; Choi, B.-G.; Kim, E.-N.; Baik, H.-M.; Choe, B.-Y.; Naruse, S.

    2001-01-01

    Introduction. To add metabolic information during stereotactic biopsy target selection, the authors adopted proton chemical shift imaging ( 1 H CSI)-directed stereotactic biopsy. Currently, proton single voxel spectroscopy (SVS) technique has been reported in stereotactic biopsy. We performed 1 H CSI in combination with a stereotactic headframe and selected targets according to local metabolic information, and evaluated the pathological results. Patients and Method. The 1 H CSI-directed stereotactic biopsy was performed in four patients. 1 H CSI and conventional Gd-enhancement stereotactic MRI were performed simultaneously after the fitting of a stereotactic frame. After reconstructing the metabolic maps of N-acetylaspartate (NAA)/phosphocreatine (Cr), phosphocholine (Cho)/Cr, and Lactate/Cr ratios, focal areas of increased Cho/Cr ratio and Lac/Cr ratios were selected as target sites in the stereotactic MR images. Result. 1 H CSI is possible with the stereotactic headframe in place. No difficulty was experienced performing 1 H CSI or making a diagnosis. Pathological samples taken from areas of increased Cho/Cr ratios and decreased NAA/Cr ratios provided information upon increased cellularity, mitoses and cellular atypism, and facilitated diagnosis. Pathological samples taken from areas of increased Lac/ Cr ratio snowed predominant feature of necrosis. Conclusion. 1 H CSI was feasible with the stereotactic headframe in place. The final pathological results obtained were concordant with the local metabolic information from 1 H CSI. We believe that 1 H CSI-directed stereotactic biopsy has the potential to significantly improve the accuracy of stereotactic biopsy targeting. (author)

  13. A direct search for stable magnetic monopoles produced in positron proton collisions at HERA

    Czech Academy of Sciences Publication Activity Database

    Aktas, A.; Andreev, V.; Anthonis, T.; Cvach, Jaroslav; Herynek, Ivan; Reimer, Petr; Sedlák, Kamil; Zálešák, Jaroslav

    2005-01-01

    Roč. 41, - (2005), s. 133-144 ISSN 1434-6044 Institutional research plan: CEZ:AV0Z10100502 Keywords : HI experiment * ep scattering * magnetic monopoles Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 3.209, year: 2005

  14. Noninvasive monitoring of radiation-induced treatment response using proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging in a colorectal tumor model

    International Nuclear Information System (INIS)

    Seierstad, Therese; Roe, Kathrine; Olsen, Dag Rune

    2007-01-01

    Background and purpose: To examine whether in vivo proton magnetic resonance spectroscopy ( 1 H MRS) and diffusion-weighted magnetic resonance imaging (DW-MRI) can monitor radiation-induced changes in HT29 xenografts in mice. Materials and methods: HT29 xenografts in mice received a dose of 15 Gy. In vivo 1 H MRS and DW-MRI were acquired pretreatment and 1, 3, 6 and 10 days post-irradiation. After imaging, tumors were excised for histological analysis. The amounts of necrosis, fibrosis and viable cells in the cross sections were scored and compared to changes in apparent diffusion coefficient (ADC) and choline/water ratio. Results: Radiation-induced necrosis in the xenografts was observed as increased tumor ADC. In-growth of fibrosis three days post-irradiation restricting water mobility was accompanied by decreased tumor ADC. Choline/water ratio correlated with metabolic activity and tumor growth. Conclusions: ADC and choline/water ratio assessed by in vivo DW-MRI and 1 H MRS depicts radiation-induced changes in HT29 xenografts following irradiation

  15. Effects of acupuncture therapy on abdominal fat and hepatic fat content in obese children: a magnetic resonance imaging and proton magnetic resonance spectroscopy study.

    Science.gov (United States)

    Zhang, Hong; Peng, Yun; Liu, ZuXiang; Li, Shilian; Lv, Zhongli; Tian, LiFang; Zhu, Jie; Zhao, XuNa; Chen, Min

    2011-05-01

    The aim of this study was to use magnetic resonance imaging (MRI) together with proton magnetic resonance spectroscopy ((1)H-MRS) to study the influence of acupuncture therapy on abdominal fat and hepatic fat content in obese children. The design was a longitudinal, clinical intervention study of acupuncture therapy. SUBJECTS were 10 healthy, obese children (age: 11.4 ± 1.65 years, body-mass index [BMI]: 29.03 ± 4.81 kg/m(2)). Measurements included various anthropometric parameters, abdominal fat (assessed by MRI) and hepatic fat content (assessed by (1)H-MRS) at baseline and after 1 month of acupuncture therapy. One (1) month of acupuncture therapy significantly reduced the subjects' BMI by 3.5% (p = 0.005), abdominal visceral adipose tissue (VAT) volume by 16.04% (p  0.05). There was a significant correlation between the level of abdominal fat (SAT, VAT) and anthropometric parameters (weight, BMI, waist circumferences, hip circumferences). There was no statistically significant correlation between IHTG and anthropometric parameters or abdominal fat content. The first direct experimental evidence is provided demonstrating that acupuncture therapy significantly reduces BMI and abdominal adipose tissue by reducing abdominal VAT content without significant changes in body weight, waist circumference, hip circumference, WHR, abdominal SAT, or IHTG content. Thus, the use of acupuncture therapy to selectively target a reduction in abdominal VAT content should become more important and more popular in the future.

  16. Optically transmitted and inductively coupled electric reference to access in vivo concentrations for quantitative proton-decoupled ¹³C magnetic resonance spectroscopy.

    Science.gov (United States)

    Chen, Xing; Pavan, Matteo; Heinzer-Schweizer, Susanne; Boesiger, Peter; Henning, Anke

    2012-01-01

    This report describes our efforts on quantification of tissue metabolite concentrations in mM by nuclear Overhauser enhanced and proton decoupled (13) C magnetic resonance spectroscopy and the Electric Reference To access In vivo Concentrations (ERETIC) method. Previous work showed that a calibrated synthetic magnetic resonance spectroscopy-like signal transmitted through an optical fiber and inductively coupled into a transmit/receive coil represents a reliable reference standard for in vivo (1) H magnetic resonance spectroscopy quantification on a clinical platform. In this work, we introduce a related implementation that enables simultaneous proton decoupling and ERETIC-based metabolite quantification and hence extends the applicability of the ERETIC method to nuclear Overhauser enhanced and proton decoupled in vivo (13) C magnetic resonance spectroscopy. In addition, ERETIC signal stability under the influence of simultaneous proton decoupling is investigated. The proposed quantification method was cross-validated against internal and external reference standards on human skeletal muscle. The ERETIC signal intensity stability was 100.65 ± 4.18% over 3 months including measurements with and without proton decoupling. Glycogen and unsaturated fatty acid concentrations measured with the ERETIC method were in excellent agreement with internal creatine and external phantom reference methods, showing a difference of 1.85 ± 1.21% for glycogen and 1.84 ± 1.00% for unsaturated fatty acid between ERETIC and creatine-based quantification, whereas the deviations between external reference and creatine-based quantification are 6.95 ± 9.52% and 3.19 ± 2.60%, respectively. Copyright © 2011 Wiley Periodicals, Inc.

  17. Detection of forward-scattered protons in photon-induced reactions on the nucleon

    International Nuclear Information System (INIS)

    Koop, Karsten

    2015-01-01

    The study of excitation spectra of hadrons can contribute to a better understanding of the strong interaction. A method is the photoproduction of mesons on the nucleon. Because of the width of the excited states a consideration of polarization observables is helpful in order to be abble to separate overlapping states. In this thesis an experiment for the study of the polarization of the recoil proton is presented. The setup presented here is part of the BGO-OD experiment at the ELSA electron accelerator of the Bonn university. BGO-OD consists of an electromagnetic calorimeter, which surrounds the target, several track detectors in forward direction, and a dipole magnet for the momentum measurement of charged particles. The presented detector is located immediately behind the liquid hydrogen target. In order to be able to determine the polarization of the recoil proton these are scattered on an analyzer, whereby the distribution of the scattering angles is polarization dependent. In this thesis a detector was developed in order to determine the track of the charged particles before and behind the target and by this the scattering angle. Furthermore simulations were performed, which show the realizability of the experiment.

  18. Neurodegenerative evidences during early onset of depression in CMS rats as detected by proton magnetic resonance spectroscopy at 7 T.

    Science.gov (United States)

    Hemanth Kumar, B S; Mishra, Sushanta Kumar; Rana, Poonam; Singh, Sadhana; Khushu, Subash

    2012-06-15

    Depression is a complex psychiatric disorder characterized by anhedonia and feeling of sadness and chronic mild stress (CMS) seems to be a valuable animal model of depression. CMS animal model was induced and validated using behavioral studies. In the present study we investigated the neuro-metabolite changes occurring in prefrontal cortex and hippocampus during the onset of depression, in CMS rat model using in vivo proton magnetic resonance spectroscopy ((1)H MRS) at field strength of 7 T. Results showed that CMS caused depression-like behavior in rats, as indicated by the decrease in sucrose consumption and locomotor activity. (1)H MRS was performed in both control and CMS rats (n=10, in each group) and the quantitative assessment of the neurometabolites was done using LC model. Relative concentrations of all the metabolites along with the macromolecules were calculated for analysis. The results revealed a significant decrease of glutamate (Glu), glutamine (Gln), NAA+NAAG, Glx and GABA levels in both hippocampus and prefrontal cortex of CMS animals and an elevated level of myo-ionisitol (mI) and taurine (Tau) was observed only in hippocampus. These metabolite fluctuations revealed by proton MRS indicate that there might be change in the neuronal integrity of the glial cells and neurons within prefrontal cortex and hippocampus in CMS model of depression. The present study also suggests that there may be a degenerative process concerning the brain morphology in the CMS rats. The overall finding using (1)H MRS suggests that, there might be a major role of the glia and neuron in the onset of depression. Copyright © 2012 Elsevier B.V. All rights reserved.

  19. A gun recoil system employing a magnetorheological fluid damper

    International Nuclear Information System (INIS)

    Li, Z C; Wang, J

    2012-01-01

    This research aims to design and control a full scale gun recoil buffering system which works under real firing impact loading conditions. A conventional gun recoil absorber is replaced with a controllable magnetorheological (MR) fluid damper. Through dynamic analysis of the gun recoil system, a theoretical model for optimal design and control of the MR fluid damper for impact loadings is derived. The optimal displacement, velocity and optimal design rules are obtained. By applying the optimal design theory to protect against impact loadings, an MR fluid damper for a full scale gun recoil system is designed and manufactured. An experimental study is carried out on a firing test rig which consists of a 30 mm caliber, multi-action automatic gun with an MR damper mounted to the fixed base through a sliding guide. Experimental buffering results under passive control and optimal control are obtained. By comparison, optimal control is better than passive control, because it produces smaller variation in the recoil force while achieving less displacement of the recoil body. The optimal control strategy presented in this paper is open-loop with no feedback system needed. This means that the control process is sensor-free. This is a great benefit for a buffering system under impact loading, especially for a gun recoil system which usually works in a harsh environment. (paper)

  20. High-resolution elastic recoil detection utilizing Bayesian probability theory

    International Nuclear Information System (INIS)

    Neumaier, P.; Dollinger, G.; Bergmaier, A.; Genchev, I.; Goergens, L.; Fischer, R.; Ronning, C.; Hofsaess, H.

    2001-01-01

    Elastic recoil detection (ERD) analysis is improved in view of depth resolution and the reliability of the measured spectra. Good statistics at even low ion fluences is obtained utilizing a large solid angle of 5 msr at the Munich Q3D magnetic spectrograph and using a 40 MeV 197 Au beam. In this way the elemental depth profiles are not essentially altered during analysis even if distributions with area densities below 1x10 14 atoms/cm 2 are measured. As the energy spread due to the angular acceptance is fully eliminated by ion-optical and numerical corrections, an accurate and reliable apparatus function is derived. It allows to deconvolute the measured spectra using the adaptive kernel method, a maximum entropy concept in the framework of Bayesian probability theory. In addition, the uncertainty of the reconstructed spectra is quantified. The concepts are demonstrated at 13 C depth profiles measured at ultra-thin films of tetrahedral amorphous carbon (ta-C). Depth scales of those profiles are given with an accuracy of 1.4x10 15 atoms/cm 2

  1. Characterization of the ELIMED Permanent Magnets Quadrupole system prototype with laser-driven proton beams

    Czech Academy of Sciences Publication Activity Database

    Schillaci, F.; Pommarel, L.; Romano, F.; Cuttone, G.; Costa, M.; Giove, D.; Maggiore, M.; Russo, A.D.; Scuderi, Valentina; Malka, V.; Vauzour, B.; Flacco, A.; Cirrone, G.A.P.

    2016-01-01

    Roč. 11, Jul (2016), s. 1-16, č. článku T07005. ISSN 1748-0221 R&D Projects: GA MŠk EF15_008/0000162; GA MŠk LQ1606 Grant - others:ELI Beamlines(XE) CZ.02.1.01/0.0/0.0/15_008/0000162 Institutional support: RVO:68378271 Keywords : cceleration cavities and magnets superconducting * beam dynamics * Accelerator modelling and simulations * Beam Optics Subject RIV: BL - Plasma and Gas Discharge Physics OBOR OECD: Fluids and plasma physics (including surface physics) Impact factor: 1.220, year: 2016

  2. Glutamatergic system dysfunction in schizophrenia. A proton magnetic resonance spectroscopy (1H MRS) study

    International Nuclear Information System (INIS)

    Szulc, A.; Galinska, B.; Czernikiewicz, A.; Tarasow, E.; Kubas, B.; Dzienis, W.; Walecki, J.

    2004-01-01

    The present study was performed to determine whether there are any differences in metabolite levels as measured by 1 H MRS between chronic and first-episode schizophrenic patients. 17 patients with the diagnosis of chronic schizophrenia and 31 patients with first-episode schizophrenia (ICD-10) were included into the study. The patients were assessed by means of PANSS, CGI and Calgary scales.We also examined 13 healthy persons as control group. MRI and MRS procedures: Proton resonance spectroscopy was performed on a 1,5 MR scanner, PRESS sequence, TR=1500 ms, TE=35 ms, number of repetition=192 and included suppression of water by MOIST sequence. Each volume element (voxel) had dimension of 2x2x2 cm and was localised in the left frontal lobe, in the left temporal lobe and in left thalamus. Complex containing glutamine (Gln), glutamate (Glu) and gamma-aminobutyric acid (GABA) was measured. Ratios of metabolite to creatine and unsuppressed water signal were analysed. We didn't find any significant differences in Glx levels between chronic and first-episode patients and between chronic patients and controls in all studied regions.In the left temporal lobe Glx/Cr ratio was significantly higher in first-episode patients in comparison to controls.We observed significant positive correlation between Glx/Cr level in the left temporal lobe and CGI and PANSS-Negative scores, and negative correlation between Glx/H 2 0 level in the left temporal lobe and PANSS-Positive score. Increased Glx level in the left temporal lobe in first-episode patients suggest that altered glutamatergic activity in this region is present at the onset of disease and doesn't progress over time. (author)

  3. Measurement of the analyzing power for pion-proton elastic scattering between 471 and 687 MeV/c

    International Nuclear Information System (INIS)

    Mokhtari-Amirmajdi, A.

    1984-01-01

    The analyzing power, A/sub N/, has been measured for π/sup +/-/p → π/sup +/-/p at 471, 547, 625, and 687 MeV/c in an angular range corresponding to -0.9 less than or equal to cos(theta)/sub cm/ less than or equal to 0.8. A polarized proton target with polarization axis normal to the scattering plane was used. The scattered pion and recoil proton were detected in coincidence, using a magnetic spectrometer and a wire chamber/scintillator array, except in cases where one of the particles was kinematically inaccessible. Statistical uncertainties in the data are as low as 0.02; systematic uncertainties are estimated to be less than 5%. The π - p data are characterized by large values of analyzing power, and rapid variations in the angular distribution with incident momentum. The measurements are compared with the results of existing partical wave analysis

  4. Nonlinear Alfvén waves, discontinuities, proton perpendicular acceleration, and magnetic holes/decreases in interplanetary space and the magnetosphere: intermediate shocks?

    Directory of Open Access Journals (Sweden)

    B. T. Tsurutani

    2005-01-01

    Full Text Available Alfvén waves, discontinuities, proton perpendicular acceleration and magnetic decreases (MDs in interplanetary space are shown to be interrelated. Discontinuities are the phase-steepened edges of Alfvén waves. Magnetic decreases are caused by a diamagnetic effect from perpendicularly accelerated (to the magnetic field protons. The ion acceleration is associated with the dissipation of phase-steepened Alfvén waves, presumably through the Ponderomotive Force. Proton perpendicular heating, through instabilities, lead to the generation of both proton cyclotron waves and mirror mode structures. Electromagnetic and electrostatic electron waves are detected as well. The Alfvén waves are thus found to be both dispersive and dissipative, conditions indicting that they may be intermediate shocks. The resultant 'turbulence' created by the Alfvén wave dissipation is quite complex. There are both propagating (waves and nonpropagating (mirror mode structures and MDs byproducts. Arguments are presented to indicate that similar processes associated with Alfvén waves are occurring in the magnetosphere. In the magnetosphere, the 'turbulence' is even further complicated by the damping of obliquely propagating proton cyclotron waves and the formation of electron holes, a form of solitary waves. Interplanetary Alfvén waves are shown to rapidly phase-steepen at a distance of 1AU from the Sun. A steepening rate of ~35 times per wavelength is indicated by Cluster-ACE measurements. Interplanetary (reverse shock compression of Alfvén waves is noted to cause the rapid formation of MDs on the sunward side of corotating interaction regions (CIRs. Although much has been learned about the Alfvén wave phase-steepening processfrom space plasma observations, many facets are still not understood. Several of these topics are discussed for the interested researcher. Computer simulations and theoretical developments will be particularly useful in making further progress in

  5. The HERMES recoil photon-detector and nuclear p{sub t}-Broadening at HERMES

    Energy Technology Data Exchange (ETDEWEB)

    Haarlem, Y. van

    2007-09-15

    The first part of this work consists of hardware research and development done in order to construct and test a photon-detector as one of the three detectors of the HERMES recoil detector. The HERMES recoil detector consists of a target cell, a silicon-detector, a scintillating fiber tracker, and a photon-detector. All are inside a super-conducting magnet. The silicon detector uses energy deposition to determine the momentum of the particle because in its energy range the energy deposition is an unambiguous function of the momentum of the particle. The scintillating fiber tracker is located outside the beam-vacuum and is surrounded by the photon-detector. It consists of two barrels with layers of scintillating fibers. It detects particles by converting their energy deposition into light. It measures two space points of a charged particle and from the bending of the assigned track (in the magnetic field provided by the super-conducting magnet) a momentum measurement can be derived. The photon-detector is located between the scintillating fiber tracker and the magnet. It consists (from the inside out) of three layers of tungsten showering material followed by scintillating strips. The second part of this work is an analysis performed concerning the transverse momentum broadening of hadrons produced in deep-inelastic scattering on a nuclear target compared to a D target. (orig.)

  6. Single event upsets calculated from new ENDF/B-VI proton and neutron data up to 150 MeV

    International Nuclear Information System (INIS)

    Chadwick, M.B.

    1999-01-01

    Single-event upsets (SEU) in microelectronics are calculated from newly-developed silicon nuclear reaction recoil data that extend up to 150 MeV, for incident protons and neutrons. Calculated SEU cross sections are compared with measured data

  7. Clinical value of proton magnetic resonance spectroscopy for differentiating recurrent or residual brain tumor from delayed cerebral necrosis

    International Nuclear Information System (INIS)

    Taylor, June S.; Langston, James W.; Reddick, Wilburn E.; Kingsley, Peter B.; Ogg, Robert J.; Pui, Margaret H.; Kun, Larry E.; Jenkins, Jesse J.; Gang, Chen; Ochs, Judith J.; Sanford, Robert A.; Heideman, Richard L.

    1996-01-01

    Purpose: Delayed cerebral necrosis (DN) is a significant risk for brain tumor patients treated with high-dose irradiation. Although differentiating DN from tumor progression is an important clinical question, the distinction cannot be made reliably by conventional imaging techniques. We undertook a pilot study to assess the ability of proton magnetic resonance spectroscopy ( 1 H MRS) to differentiate prospectively between DN or recurrent/residual tumor in a series of children treated for primary brain tumors with high-dose irradiation. Methods and Materials: Twelve children (ages 3-16 years), who had clinical and MR imaging (MRI) changes that suggested a diagnosis of either DN or progressive/recurrent brain tumor, underwent localized 1 H MRS prior to planned biopsy, resection, or other confirmatory histological procedure. Prospective 1 H MRS interpretations were based on comparison of spectral peak patterns and quantitative peak area values from normalized spectra: a marked depression of the intracellular metabolite peaks from choline, creatine, and N-acetyl compounds was hypothesized to indicate DN, and median-to-high choline with easily visible creatine metabolite peaks was labeled progressive/recurrent tumor. Subsequent histological studies identified the brain lesion as DN or recurrent/residual tumor. Results: The patient series included five cases of DN and seven recurrent/residual tumor cases, based on histology. The MRS criteria prospectively identified five out of seven patients with active tumor, and four out of five patients with histologically proven DN correctly. Discriminant analysis suggested that the primary diagnostic information for differentiating DN from tumor lay in the normalized MRS peak areas for choline and creatine compounds. Conclusions: Magnetic resonance spectroscopy shows promising sensitivity and selectivity for differentiating DN from recurrent/progressive brain tumor. A novel diagnostic index based on peak areas for choline and

  8. GABA concentration in schizophrenia patients and the effects of antipsychotic medication: a proton magnetic resonance spectroscopy study.

    Science.gov (United States)

    Tayoshi, Shin'Ya; Nakataki, Masahito; Sumitani, Satsuki; Taniguchi, Kyoko; Shibuya-Tayoshi, Sumiko; Numata, Shusuke; Iga, Jun-ichi; Ueno, Shu-ichi; Harada, Masafumi; Ohmori, Tetsuro

    2010-03-01

    Gamma-amino butyric acid (GABA) is thought to play a role in the pathophysiology of schizophrenia. High magnetic field proton magnetic resonance spectroscopy ((1)H-MRS) provides a reliable measurement of GABA in specific regions of the brain. This study measured GABA concentration in the anterior cingulate cortex (ACC) and in the left basal ganglia (ltBG) in 38 patients with chronic schizophrenia and 29 healthy control subjects. There was no significant difference in GABA concentration between the schizophrenia patients and the healthy controls in either the ACC (1.36+/-0.45 mmol/l in schizophrenia patients and 1.52+/-0.54 mmol/l in control subjects) or the ltBG (1.13+/-0.26 mmol/l in schizophrenia patients and 1.18+/-0.20 mmol/l in control subjects). Among the right handed schizophrenia patients, the GABA concentration in the ltBG was significantly higher in patients taking typical antipsychotics (1.25+/-0.24 mmol/l) than in those taking atypical antipsychotics (1.03+/-0.24 mmol/l, p=0.026). In the ACC, the GABA concentration was negatively correlated with the dose of the antipsychotics (rs=-0.347, p=0.035). In the ltBG, the GABA concentration was positively correlated with the dose of the anticholinergics (rs=0.403, p=0.015). To the best of our knowledge, this is the first study to have directly measured GABA concentrations in schizophrenia patients using (1)H-MRS. Our results suggest that there are no differences in GABA concentrations in the ACC or the ltBG of schizophrenia patients compared to healthy controls. Antipsychotic medication may cause changes in GABA concentration, and atypical and typical antipsychotics may have differing effects. It is possible that medication effects conceal inherent differences in GABA concentrations between schizophrenia patients and healthy controls. (c) 2009 Elsevier B.V. All rights reserved.

  9. Thermal Fluctuations in the Magnetic Ground State of the Molecular Cluster Mn12O12 Acetate from μSR and Proton NMR Relaxation

    International Nuclear Information System (INIS)

    Lascialfari, A.; Borsa, F.; Carretta, P.; Jang, Z.H.; Borsa, F.; Gatteschi, D.

    1998-01-01

    Measurements of the spin-lattice relaxation rate are reported for muons and protons as a function of temperature for different values of the applied magnetic field in the Mn 12 O 12 molecular cluster. Strongly field dependent maxima in the relaxation rate versus temperature are observed below 50thinspthinspK. The results are explained in terms of thermal fluctuations of the total magnetization of the cluster among the different orientations with respect to the anisotropy axis. The lifetimes of the different m components of the total spin, S T =10 , of the molecule are obtained from the experiment and shown to be consistent with the ones expected from a spin-phonon coupling mechanism. No clear evidence for macroscopic quantum tunneling was observed in the field dependence of the proton relaxation rate at low T . copyright 1998 The American Physical Society

  10. 7T Proton Magnetic Resonance Spectroscopy of Gamma-Aminobutyric Acid, Glutamate, and Glutamine Reveals Altered Concentrations in Patients With Schizophrenia and Healthy Siblings

    DEFF Research Database (Denmark)

    Thakkar, Katharine N; Rösler, Lara; Wijnen, Jannie P

    2017-01-01

    BACKGROUND: The N-methyl-D-aspartate receptor hypofunction model of schizophrenia predicts dysfunction in both glutamatergic and gamma-aminobutyric acidergic (GABAergic) transmission. We addressed this hypothesis by measuring GABA, glutamate, glutamine, and the sum of glutamine plus glutamate...... concentrations in vivo in patients with schizophrenia using proton magnetic resonance spectroscopy at 7T, which allows separation of metabolites that would otherwise overlap at lower field strengths. In addition, we investigated whether altered levels of GABA, glutamate, glutamine, and the sum of glutamine plus...... glutamate reflect genetic vulnerability to schizophrenia by including healthy first-degree relatives. METHODS: Proton magnetic resonance spectroscopy at 7T was performed in 21 patients with chronic schizophrenia who were taking medication, 23 healthy first-degree relatives of patients with schizophrenia...

  11. A proton nuclear magnetic resonance investigation of proximal histidyl residues in human normal and abnormal hemoglobins: a probe for the heme pocket

    International Nuclear Information System (INIS)

    Takahashi, S.; Lin, A.K.L.; Ho, C.

    1982-01-01

    Proton nuclear magnetic resonance spectroscopy at 250 MHz has been used to investigate the conformations of proximal histidyl residues of human normal adult hemoglobin, hemoglobin Kempsey [K145(HC2) Tyr #betta# Asp], and hemoglobin McKees Rocks [K145(HC2) Tyr #betta# Term] around neutral pH in H 2 O at 27 0 C, all in the deoxy form. Two resonances that occur between 58 and 76 ppm downfield from the water proton signal have been assigned to the hyperfine shifted proximal histidyl NH-exchangeable protons of the J and K-chains of deoxyhemoglobin. These two resonances are sensitive to the quaternary state of hemoglobin, amino acid substitutions in the J 1 K 2 -subunit interface and in the carboxy-terminal region of the K-chain, and the addition of organic phosphates. The experimental results show that there are differences in the heme pockets among these four hemoglobins studied. The structural and dynamic information derived from the hyperfine shifted proximal histidyl NH-exchangeable proton resonances complement that obtained from the ferrous hyperfine shifted and exchangeable proton resonances of deoxyhemoglobin over the spectral region from 5 to 20 ppm downfield from H 2 O. The relationship between these findings and Perutz's stereochemical mechanism for the cooperative oxygenation of hemoglobin is discussed

  12. Clinical application of proton magnetic resonance spectroscopy in differential diagnosis of intracranial lesions with ring-like enhancement

    International Nuclear Information System (INIS)

    Lai Ying; Cheng Kailiang; Zhang Mengchao; Liu Yunxia; Wang Wei

    2009-01-01

    Objective: To study the value of clinical application of 1 H proton magnetic resonance spectroscopy ( 1 H MRS) in the differential diagnosis of intracranial lesions with ring-like enhancement. Methods: 28 cases were diagnosed of intracranial lesions with ring-like enhancement by clinical examination and pathologic test. A total of 28 ratios cases included 6 cases high grade glioma, 10 cases of metastatic carcinoma (n=10) and 12 cases of brain abscess, after examined with 1HMRS, the ratios of various metabolites in focal center, enhancement ring,perifocal edema region and normal control group were detected and compared. Results: The ratios of NAA/Cho, Cho/Cr and NAA/Cr in focal center had no significantly differences between high grade glioma and metastatic carcinoma (P>0.05). The peak of NAA was significantly different between high grade glioma and metastatic carcinoma (P 0.05). The peak of AA was characteristic of brain abscess. The ratio of Cho/Cr 0 in brain abscess was significantly lower than those in high grade glioma and metastatic carcinoma (P 0 denoted the Cho content of contralateral normal brain region). These results accorded with the result of pathological examination. Conclusion: 1 HMRS can improve the diagnostic accuracy of intracranial lesions with ring-like enhancement. (authors)

  13. Proton magnetic resonance spectroscopy ((1H-MRS reveals geniculocalcarine and striate area degeneration in primary glaucoma.

    Directory of Open Access Journals (Sweden)

    Yan Zhang

    Full Text Available BACKGROUND: Glaucoma is a collection of neurodegenerative diseases that affect both the retina and the central visual pathway. We investigated whether metabolites' concentrations changed in the geniculocalcarine (GCT and the striate area of occipital lobe by proton magnetic resonance spectroscopy ((1H-MRS, suggesting neurodegeneration of the central visual pathway in primary glaucoma. METHODOLOGY/PRINCIPAL FINDINGS: 20 patients with glaucoma in both eyes were paired with 20 healthy volunteers in same gender and an age difference less than 3 years. All the participants were examined by MR imaging including T1 Flair, T2 FSE and (1H-MRS. The T1 intensity and T2 intensity of their GCTs and striate areas were measured. The ratio of N-acetylaspartate (NAA/Creatine (Cr, Choline (Cho/Cr, glutamine and glutamate (Glx/Cr were derived by multi-voxels (1H-MRS in the GCT and the striate area of each brain hemisphere. The T1 intensity and T2 intensity had no difference between the groups. Significant decreases in NAA/Cr and Cho/Cr but no difference in Glx/Cr was found between the groups in both the GCT and the striate area. CONCLUSIONS/SIGNIFICANCE: Primary glaucoma affects metabolites' concentrations in the GCT and the striate area suggesting there is ongoing neurodegenerative process.

  14. Correlation between memory, proton magnetic resonance spectroscopy, and interictal epileptiform discharges in temporal lobe epilepsy related to mesial temporal sclerosis.

    Science.gov (United States)

    Mantoan, Marcele Araújo Silva; Caboclo, Luís Otávio Sales Ferreira; de Figueiredo Ferreira Guilhoto, Laura Maria; Lin, Katia; da Silva Noffs, Maria Helena; de Souza Silva Tudesco, Ivanda; Belzunces, Erich; Carrete, Henrique; Bussoletti, Renato Tavares; Centeno, Ricardo Silva; Sakamoto, Américo Ceiki; Yacubian, Elza Márcia Targas

    2009-11-01

    The aim of the study described here was to examine the relationship between memory function, proton magnetic resonance spectroscopy ((1)H-MRS) abnormalities, and interictal epileptiform discharge (IED) lateralization in patients with temporal lobe epilepsy (TLE) related to unilateral mesial temporal sclerosis. We assessed performance on tests of memory function and intelligence quotient (IQ) in 29 right-handed outpatients and 24 controls. IEDs were assessed on 30-minute-awake and 30-minute-sleep EEG samples. Patients had (1)H-MRS at 1.5 T. There was a negative correlation between IQ (P=0.031) and Rey Auditory Verbal Learning Test results (P=0.022) and epilepsy duration; between(1)H-MRS findings and epilepsy duration (P=0.027); and between N-acetylaspartate (NAA) levels and IEDs (P=0.006) in contralateral mesial temporal structures in the left MTS group. (1)H-MRS findings, IEDs, and verbal function were correlated. These findings suggest that IEDs and NAA/(Cho+Cr) ratios reflecting neural metabolism are closely related to verbal memory function in mesial temporal sclerosis. Higher interictal activity on the EEG was associated with a decline in total NAA in contralateral mesial temporal structures.

  15. In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain

    Directory of Open Access Journals (Sweden)

    Joo Chan-Gyu

    2009-06-01

    Full Text Available Abstract Background In vivo proton magnetic resonance spectroscopy (1H-MRS studies of HIV-infected humans have demonstrated significant metabolic abnormalities that vary by brain region, but the causes are poorly understood. Metabolic changes in the frontal cortex, basal ganglia and white matter in 18 SIV-infected macaques were investigated using MRS during the first month of infection. Results Changes in the N-acetylaspartate (NAA, choline (Cho, myo-inositol (MI, creatine (Cr and glutamine/glutamate (Glx resonances were quantified both in absolute terms and relative to the creatine resonance. Most abnormalities were observed at the time of peak viremia, 2 weeks post infection (wpi. At that time point, significant decreases in NAA and NAA/Cr, reflecting neuronal injury, were observed only in the frontal cortex. Cr was significantly elevated only in the white matter. Changes in Cho and Cho/Cr were similar across the brain regions, increasing at 2 wpi, and falling below baseline levels at 4 wpi. MI and MI/Cr levels were increased across all brain regions. Conclusion These data best support the hypothesis that different brain regions have variable intrinsic vulnerabilities to neuronal injury caused by the AIDS virus.

  16. Use of chemical fractionation and proton nuclear magnetic resonance to probe the physical structure of the primary plant cell wall

    International Nuclear Information System (INIS)

    Taylor, I.E.P.; Wallace, J.C.; MacKay, A.L.; Volke, F.

    1990-01-01

    Proton magnetic resonance has been used to monitor the microscopic physical properties of etiolated hypocotyl cell walls from Phaseolus vulgaris L. at all stages in a series of chemical fractionations with ammonium oxalate and potassium hydroxide. Solid echo measurements indicate that 75% of the polymers in the intact cell wall, including the cellulose and most of the hemicelluloses, are arranged such that there is almost complete restraint of molecular motion. The chemical fractionations generally altered the physical structures of the remaining cell wall components. Digestion with 0.25% ammonium oxalate/oxalic acid solubilized the pectin and increased the mobility of the hemicellulose I component. Extraction with 4% potassium hydroxide removed the hemicellulose I component and loosened the hemicellulose II. Further extraction with 24% potassium hydroxide removed the hemicellulose II and loosened some of the cellulose. The cellulose crystallinity, as monitored by Jeener echo measurements decreased from 83% to 63% during these fractionations. We conclude that, while hemicellulose I is firmly attached to hemicellulose II, it is not in a closely packed structure. Hemicellulose II is strongly bound to cellulose and has a much more closely packed structure

  17. Proton magnetic resonance spectroscopy shows lower intramyocellular lipid accumulation in middle-aged subjects predisposed to familial longevity.

    Science.gov (United States)

    Wijsman, C A; van Opstal, A M; Kan, H E; Maier, A B; Westendorp, R G J; Slagboom, P E; Webb, A G; Mooijaart, S P; van Heemst, D

    2012-02-01

    Families predisposed to longevity show enhanced glucose tolerance and skeletal muscle insulin sensitivity compared with controls, independent of body composition and physical activity. Intramyocellular lipid (IMCL) accumulation in skeletal muscle has been associated with insulin resistance. Here, we assessed whether subjects enriched for familial longevity have lower IMCL levels. We determined IMCL levels in 48 subjects from the Leiden Longevity Study, comprising 24 offspring of nonagenarian siblings and 24 partners thereof as control subjects. IMCL levels were assessed noninvasively using short echo time proton magnetic resonance spectroscopy ((1)H-MRS) of the tibialis anterior muscle with a 7 Tesla human MR scanner. IMCL levels were calculated relative to the total creatine (tCr) CH3 signal. Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ). After correction for age, sex, BMI, and physical activity, offspring of long-lived nonagenarian siblings tended to show lower IMCL levels compared with controls (IMCL/tCr: 3.1 ± 0.5 vs. 4.5 ± 0.5, respectively, P = 0.051). In a pairwise comparison, this difference reached statistical significance (P = 0.038). We conclude that offspring of nonagenarian siblings predisposed to longevity show lower IMCL levels compared with environmentally matched control subjects. Future research should focus on assessing what mechanisms may explain the lower IMCL levels in familial longevity.

  18. Detection of inflammatory bowel disease by proton magnetic resonance spectroscopy (1H MRS using an animal model

    Directory of Open Access Journals (Sweden)

    Dolenko Brion

    2007-11-01

    Full Text Available Abstract Background The aim of this study was to analyze the potential of proton magnetic resonance spectroscopy (1H MRS in diagnosing early inflammatory bowel disease (IBD. Methods Thirty male Sprague Dawley rats were fed 2% carrageenan in their diet for either 1 or 2 weeks. 1H MRS was performed ex-vivo on colonic mucosal samples (n = 123 and the spectra were analyzed by a multivariate method of analysis. The results of the multivariate analysis were correlated with histological analysis performed using H & E stain for the presence of inflammation in the samples from each group. Results Multivariate analysis classified the samples in their respective groups with an accuracy of 82%. Our region selection algorithm identified four regions in the spectra as being discriminatory. The metabolites assigned to these regions include creatine, phosphatidylcholine, the -CH2HC= group in fatty acyl chain, and the glycerol backbone of lipids. The differences in concentration of these metabolites in each group offer insight into the biochemical changes occurring during IBD and confer diagnostic potential to 1H MRS as a tool to study colonic inflammation in conjunction with biopsy. Conclusion 1H MRS is a sensitive tool to detect early colonic inflammation in an animal model of IBD.

  19. Proton Magnetic Resonance Spectroscopy Study on the Metabolism Changes of Cerebellum in Patients with Post-Stroke Depression.

    Science.gov (United States)

    Zhang, Lei; Sui, Ru-Bo

    2017-01-01

    To study the metabolic changes of cerebellum by proton magnetic resonance Spectroscopy (1H-MRS) and discuss the relationships between the cerebellar changes and depression severity in patients with post-stroke depression. Data of demographic characteristics, individual history and life style of all subjects were collected. 40 patients with stroke and 20 controls were enrolled. All groups received T1WI, T2WI, DWI and 1H-MRS examination. The cerebral infarction volume and the distribution and severity of leukoaraiosis were evaluated. The ratios of NAA/Cr, Cho/Cr and Cho/NAA in the cerebellum were calculated. There were no statistical significant difference in the NAA/Cr, Cho/Cr and Cho/NAA ratios in bilateral cerebellum between CONT group and NORM group. The Cho/Cr and Cho/NAA ratios in the cerebellum contralateral to the stroke region were higher in PSD group than those in NORM and CONT groups, and the Cho/Cr and Cho/NAA ratios in the cerebellum ipsilateral to the stroke region were similar with those in NORM and CONT groups. However, there were no statistical significant difference in the NAA/Cr ratios in bilateral cerebellum among three groups. The result shows preliminarily that the cerebellum involves in the development of post-stroke depression. © 2017 The Author(s). Published by S. Karger AG, Basel.

  20. Compton recoil electron tracking with silicon strip detectors

    International Nuclear Information System (INIS)

    O'Neill, T.J.; Ait-Ouamer, F.; Schwartz, I.; Tumer, O.T.; White, R.S.; Zych, A.D.

    1992-01-01

    The application of silicon strip detectors to Compton gamma ray astronomy telescopes is described in this paper. The Silicon Compton Recoil Telescope (SCRT) tracks Compton recoil electrons in silicon strip converters to provide a unique direction for Compton scattered gamma rays above 1 MeV. With strip detectors of modest positional and energy resolutions of 1 mm FWHM and 3% at 662 keV, respectively, 'true imaging' can be achieved to provide an order of magnitude improvement in sensitivity to 1.6 x 10 - 6 γ/cm 2 -s at 2 MeV. The results of extensive Monte Carlo calculations of recoil electrons traversing multiple layers of 200 micron silicon wafers are presented. Multiple Coulomb scattering of the recoil electron in the silicon wafer of the Compton interaction and the next adjacent wafer is the basic limitation to determining the electron's initial direction

  1. RITA, a promising Monte Carlo code for recoil implantation

    International Nuclear Information System (INIS)

    Desalvo, A.; Rosa, R.

    1982-01-01

    A computer code previously set up to simulate ion penetration in amorphous solids has been extended to handle with recoil phenomena. Preliminary results are compared with existing experimental data. (author)

  2. Analysis of metabolic changes of brain in HIV-1 seropositive patients with proton magnetic resonance spectroscopy

    International Nuclear Information System (INIS)

    Koltowska, A.; Hendrich, B.; Sokolska, V.; Mis, M.; Lubkowska, K.; Szewczyk, P.; Sasiadek, M.; Furdal, M.; Knysz, B.; Gasiorowski, J.; Gladysz, A.

    2010-01-01

    Background: Asymptomatic central nervous system involvement may occur in the early stages of the HIV infection. The aim of the study was to evaluate early brain metabolic changes by means of proton MR spectroscopy (H1MRS) in the HIV-1 seropositive patients without neurological deficits or significant abnormalities in the plain MR study. Material/Methods: The H1MRS examinations were performed with the use of a MR GE Signa 1,5 T system. There were 39 subjects examined, aged 21 to 57 years (mean age 35 years) were examined, including 25 patients infected with HIV-1 and 14 healthy volunteers who constituted a control group. The examinations were performed using the Single Voxel Spectroscopy technique with the PRESS sequence, with following parameters: TR=1500 ms, TE=35 ms, number of acquisitions =128, time of acquisition =3 min. 43 sec. Voxels of 8 cm 3 (20 x 20 x 20 mm) in size were located in the following 5 regions: posterior cingulate gyrus, grey matter of the frontal area, left basal ganglia, white matter of the left parietal area and white matter of the frontal area. The NAA/Cr, Cho/Cr, mI/Cr ratios in the defined regions of interest were statistically analyzed. Results: There was a statistically significant decrease (p < 0.05) in the NAA/Cr ratios in the posterior cingulate area and white matter of the left parietal area in HIV-1 seropositive patients, as compared to the control group. Other metabolite ratios in all the above mentioned locations showed no statistically significant differences, as was also the case for NAA/Cr ratios in grey matter of the frontal area, left basal ganglia and white matter of the frontal area. Conclusions: The reduction of NAA/Cr values revealed in H1MRS studies suggests loss of neurons/neuronal activity in the posterior cingulate area and white matter of the left parietal area, in patients with HIV-1 at the stage before clinical manifestations of retroviral infection and structural changes in the plain MR study. This may reflect a

  3. Cerebral proton magnetic resonance spectroscopy demonstrates reversibility of N-acetylaspartate/creatine in gray matter after delayed encephalopathy due to carbon monoxide intoxication

    DEFF Research Database (Denmark)

    Hansen, Marco Bo; Kondziella, Daniel; Danielsen, Else Rubæk

    2014-01-01

    with cerebral proton magnetic resonance spectroscopy showed a dramatically decrease in N-acetylaspartate to total creatine ratios and elevated lactate levels in the gray matter. Subsequently, our patient received six additional sessions of hyperbaric oxygen therapy with only minimal recovery. At six...... reversal of N-acetylaspartate to total creatine ratios in gray matter has, to our knowledge, never been described before and shows that severe, initial measurements may not predict poor long-term patient outcome....

  4. RECOILING SUPERMASSIVE BLACK HOLES IN SPIN-FLIP RADIO GALAXIES

    International Nuclear Information System (INIS)

    Liu, F. K.; Wang Dong; Chen Xian

    2012-01-01

    Numerical relativity simulations predict that coalescence of supermassive black hole (SMBH) binaries leads not only to a spin flip but also to a recoiling of the merger remnant SMBHs. In the literature, X-shaped radio sources are popularly suggested to be candidates for SMBH mergers with spin flip of jet-ejecting SMBHs. Here we investigate the spectral and spatial observational signatures of the recoiling SMBHs in radio sources undergoing black hole spin flip. Our results show that SMBHs in most spin-flip radio sources have mass ratio q ∼> 0.3 with a minimum possible value q min ≅ 0.05. For major mergers, the remnant SMBHs can get a kick velocity as high as 2100 km s –1 in the direction within an angle ∼< 40° relative to the spin axes of remnant SMBHs, implying that recoiling quasars are biased to be with high Doppler-shifted broad emission lines while recoiling radio galaxies are biased to large apparent spatial off-center displacements. We also calculate the distribution functions of line-of-sight velocity and apparent spatial off-center displacements for spin-flip radio sources with different apparent jet reorientation angles. Our results show that the larger the apparent jet reorientation angle is, the larger the Doppler-shifting recoiling velocity and apparent spatial off-center displacement will be. We investigate the effects of recoiling velocity on the dust torus in spin-flip radio sources and suggest that recoiling of SMBHs would lead to 'dust-poor' active galactic nuclei. Finally, we collect a sample of 19 X-shaped radio objects and for each object give the probability of detecting the predicted signatures of recoiling SMBH.

  5. Energy and depth resolution in elastic recoil coincidence spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Szilagyi, E., E-mail: szilagyi@rmki.kfki.h [KFKI Research Institute for Particle and Nuclear Physics, P.O. Box 49, H-1525 Budapest (Hungary)

    2010-06-15

    Elastic recoil coincidence spectrometry was implemented into the analytical ion beam simulation program DEPTH. In the calculations, effective detector geometry and multiple scattering effects are considered. Mott's cross section for the identical, spin zero particles is included. Spectra based on the individual detector signal and summing the energy of the recoiled and scattered particles originating from the same scattering events can also be calculated. To calculate this latter case, the dependency of the energy spread contributions had to be reconsidered.

  6. Energy and depth resolution in elastic recoil coincidence spectrometry

    International Nuclear Information System (INIS)

    Szilagyi, E.

    2010-01-01

    Elastic recoil coincidence spectrometry was implemented into the analytical ion beam simulation program DEPTH. In the calculations, effective detector geometry and multiple scattering effects are considered. Mott's cross section for the identical, spin zero particles is included. Spectra based on the individual detector signal and summing the energy of the recoiled and scattered particles originating from the same scattering events can also be calculated. To calculate this latter case, the dependency of the energy spread contributions had to be reconsidered.

  7. Proton-proton bremsstrahlung

    International Nuclear Information System (INIS)

    Fearing, H.W.

    1990-01-01

    We summarize some of the information about the nucleon-nucleon force which has been obtained by comparing recent calculations of proton-proton bremsstrahlung with cross section and analyzing power data from the new TRIUMF bremsstrahlung experiment. Some comments are made as to how these results can be extended to neutron-proton bremsstrahlung. (Author) 17 refs., 6 figs

  8. Investigation of the biochemical state of paramagnetic ions in vivo using the magnetic field dependence of 1/T1 of tissue protons (NMRD profile): applications to contrast agents for magnetic resonance imaging

    International Nuclear Information System (INIS)

    Koenig, S.H.; Brown, R.D. III; Spiller, M.; Wolf, G.L.

    1988-01-01

    Nuclear magnetic relaxation dispersion (NMRD) profiles of protons are obtained in homogenous aqueous solutions of the paramagnetic ions, Mn 2+ and Gd 3+ and their chelate and macromolecular complexes in vitro, giving information regarding the biochemical state of these ions. Similarly NMRD profiles of protons of excised rabbit tissues containing Mn 2+ and Gd 3+ complexes are obtained. These NMRD profiles are shown to be very useful for determining the fate of potentially useful paramagnetic NMR imaging contrast agents in vivo. (U.K.)

  9. A Proton Magnetic Resonance Spectroscopic Study in Autism Spectrum Disorder Using a 3-Tesla Clinical Magnetic Resonance Imaging (MRI) System: The Anterior Cingulate Cortex and the Left Cerebellum.

    Science.gov (United States)

    Ito, Hiromichi; Mori, Kenji; Harada, Masafumi; Hisaoka, Sonoka; Toda, Yoshihiro; Mori, Tatsuo; Goji, Aya; Abe, Yoko; Miyazaki, Masahito; Kagami, Shoji

    2017-07-01

    The pathophysiology of autism spectrum disorder (ASD) is not fully understood. We used proton magnetic resonance spectroscopy to investigate metabolite concentration ratios in the anterior cingulate cortex and left cerebellum in ASD. In the ACC and left cerebellum studies, the ASD group and intelligence quotient- and age-matched control group consisted of 112 and 114 subjects and 65 and 45 subjects, respectively. In the ASD group, γ-aminobutyric acid (GABA)+/ creatine/phosphocreatine (Cr) was significantly decreased in the anterior cingulate cortex, and glutamate (Glu)/Cr was significantly increased and GABA+/Cr was significantly decreased in the left cerebellum compared to those in the control group. In addition, both groups showed negative correlations between Glu/Cr and GABA+/Cr in the left cerebellum, and positive correlations between GABA+/Cr in the anterior cingulate cortex and left cerebellum. ASD subjects have hypoGABAergic alterations in the anterior cingulate cortex and hyperglutamatergic/hypoGABAergic alterations in the left cerebellum.

  10. Optimizing Higgs factories by modifying the recoil mass

    Energy Technology Data Exchange (ETDEWEB)

    Gu, Jiayin [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Chinese Academy of Sciences, Beijing (China). Center for Future High Energy Physics; Li, Ying-Ying [Hong Kong Univ. of Science and Technology, Kowloon (China). Dept. of Physics

    2017-10-15

    It is difficult to measure the WW-fusion Higgs production process (e{sup +}e{sup -}→ν anti νh) at a lepton collider with a center of mass energy of 240-250 GeV due to its small rate and the large background from the Higgsstrahlung process with an invisible Z (e{sup +}e{sup -}→hZ, Z→ν anti ν). We construct a modified recoil mass variable, m{sup p}{sub recoil}, defined using only the 3-momentum of the reconstructed Higgs particle, and show that it can better separate the WW-fusion and Higgsstrahlung events than the original recoil mass variable m{sub recoil}. Consequently, the m{sup p}{sub recoil} variable can be used to improve the overall precisions of the extracted Higgs couplings, in both the conventional framework and the effective-field-theory framework. We also explore the application of the m{sup p}{sub recoil} variable in the inclusive cross section measurements of the Higgsstrahlung process, while a quantitive analysis is left for future studies.

  11. Optimizing Higgs factories by modifying the recoil mass

    Science.gov (United States)

    Gu, Jiayin; Li, Ying-Ying

    2018-02-01

    It is difficult to measure the WW-fusion Higgs production process ({{{e}}}+{{{e}}}-\\to {{ν }}\\bar{{{ν }}}{{h}}) at a lepton collider with a center of mass energy of 240-250 GeV due to its small rate and the large background from the Higgsstrahlung process with an invisible Z ({{{e}}}+{{{e}}}-\\to {{hZ}},{{Z}}\\to {{ν }}\\bar{{{ν }}}). We construct a modified recoil mass variable, {m}{{recoil}}p, defined using only the 3-momentum of the reconstructed Higgs particle, and show that it can separate the WW-fusion and Higgsstrahlung events better than the original recoil mass variable m recoil. Consequently, the {m}{{recoil}}p variable can be used to improve the overall precisions of the extracted Higgs couplings, in both the conventional framework and the effective-field-theory framework. We also explore the application of the {m}{{recoil}}p variable in the inclusive cross section measurements of the Higgsstrahlung process, while a quantitive analysis is left for future studies. JG is Supported by an International Postdoctoral Exchange Fellowship Program between the Office of the National Administrative Committee of Postdoctoral Researchers of China (ONACPR) and DESY. YYL is Supported by Hong Kong PhD Fellowship (HKPFS) and the Collaborative Research Fund (CRF) (HUKST4/CRF/13G)

  12. Characterization of proton exchange membrane materials for fuel cells by solid state nuclear magnetic resonance

    Energy Technology Data Exchange (ETDEWEB)

    Kong, Zueqian [Iowa State Univ., Ames, IA (United States)

    2010-01-01

    Solid-state nuclear magnetic resonance (NMR) has been used to explore the nanometer-scale structure of Nafion, the widely used fuel cell membrane, and its composites. We have shown that solid-state NMR can characterize chemical structure and composition, domain size and morphology, internuclear distances, molecular dynamics, etc. The newly-developed water channel model of Nafion has been confirmed, and important characteristic length-scales established. Nafion-based organic and inorganic composites with special properties have also been characterized and their structures elucidated. The morphology of Nafion varies with hydration level, and is reflected in the changes in surface-to-volume (S/V) ratio of the polymer obtained by small-angle X-ray scattering (SAXS). The S/V ratios of different Nafion models have been evaluated numerically. It has been found that only the water channel model gives the measured S/V ratios in the normal hydration range of a working fuel cell, while dispersed water molecules and polymer ribbons account for the structures at low and high hydration levels, respectively.

  13. Proton magnetic resonance spectroscopy of periventricular white matter and hippocampus in obstructive sleep apnea patients

    International Nuclear Information System (INIS)

    Kızılgöz, Volkan; Aydın, Hasan; Tatar, İdil Güneş; Hekimoğlu, Baki; Ardıç, Sadık; Fırat, Hikmet; Dönmez, Cem

    2013-01-01

    The purpose of this study was to diagnose the hypoxic impairment by Magnetic resonance spectroscopy (MRS), an advanced MR imaging technique, which could not be visualised by routine imaging methods in patients with obstructive sleep apnea (OSA). 20 OSA patients and 5 controls were included in this prospective research. MRS was performed on these 25 subjects to examine cerebral hypoxemia in specific regions (periventricular white matter and both hippocampi). Polysomnography was assumed as the gold standard. Statistical analysis was assessed by Mann-Whitney U test and Receiver operating characteristics (ROC) curve for NAA/Cho, NAA/Cr and Cho/Cr ratios. In the periventricular white matter, NAA/Cho ratio in OSA patients was significantly lower than in the control group (p<0.05). There were no statistical differences between the OSA and the control group for NAA/Cho, NAA/Cr and Cho/Cr ratios for both hippocampal regions. Additionally, Cho/Cr ratio in the periventricular white matter region of OSA group was higher than in the control group (p<0.05). Hypoxic impairment induced by repeated episodes of apnea leads to significant neuronal damage in OSA patients. MRS provides valuable information in the assessment of hypoxic ischemic impairment by revealing important metabolite ratios for the specific areas of the brain

  14. Proton magnetic resonance imaging for assessment of lung function and respiratory dynamics

    International Nuclear Information System (INIS)

    Eichinger, Monika; Tetzlaff, Ralf; Puderbach, Michael; Woodhouse, Neil; Kauczor, H.-U.

    2007-01-01

    Since many pulmonary diseases present with a variable regional involvement, modalities for assessment of regional lung function gained increasing attention over the last years. Together with lung perfusion and gas exchange, ventilation, as a result of the interaction of the respiratory pump and the lungs, is an indispensable component of lung function. So far, this complex mechanism is still mainly assessed indirectly and globally. A differentiation between the individual determining factors of ventilation would be crucial for precise diagnostics and adequate treatment. By dynamic imaging of the respiratory pump, the mechanical components of ventilation can be assessed regionally. Amongst imaging modalities applicable to this topic, magnetic resonance imaging (MRI), as a tool not relying on ionising radiation, is the most attractive. Recent advances in MRI technology have made it possible to assess diaphragmatic and chest wall motion, static and dynamic lung volumes, as well as regional lung function. Even though existing studies show large heterogeneity in design and applied methods, it becomes evident that MRI is capable to visualise pulmonary function as well as diaphragmatic and thoracic wall movement, providing new insights into lung physiology. Partly contradictory results and conclusions are most likely caused by technical limitations, limited number of studies and small sample size. Existing studies mainly evaluate possible imaging techniques and concentrate on normal physiology. The few studies in patients with lung cancer and emphysema already give a promising outlook for these techniques from which an increasing impact on improved and quantitative disease characterization as well as better patient management can be expected

  15. Investigating the Dissolution Performance of Amorphous Solid Dispersions Using Magnetic Resonance Imaging and Proton NMR

    Directory of Open Access Journals (Sweden)

    Francesco Tres

    2015-09-01

    Full Text Available We have investigated the dissolution performance of amorphous solid dispersions of poorly water-soluble bicalutamide in a Kollidon VA64 polymeric matrix as a function of the drug loading (5% vs. 30% bicalutamide. A combined suite of state-of-the-art analytical techniques were employed to obtain a clear picture of the drug release, including an integrated magnetic resonance imaging UV-Vis flow cell system and 1H-NMR. Off-line 1H-NMR was used for the first time to simultaneously measure the dissolution profiles and rates of both the drug and the polymer from a solid dispersion. MRI and 1H-NMR data showed that the 5% drug loading compact erodes linearly, and that bicalutamide and Kollidon VA64 are released at approximately the same rate from the molecular dispersion. For the 30% extrudate, data indicated a slower water ingress into the compact which corresponds to a slower dissolution rate of both bicalutamide and Kollidon VA64.

  16. Classification of brain tumors by means of proton nuclear magnetic resonance (NMR) spectroscopy

    International Nuclear Information System (INIS)

    Sottile, V.S.; Zanchi, D.E.

    2017-01-01

    In the present work, at the request of health professionals, a computer application named “ViDa” was developed. The aim of this study is to differentiate brain lesions according to whether or not they are tumors, and their subsequent classification into different tumor types using magnetic resonance spectroscopy (SVS) with an echo time of 30 milliseconds. For this development, different areas of knowledge were integrated, among which are Artificial intelligence, physics, programming, physiopathology, images in medicine, among others. Biomedical imaging can be divided into two stages: the pre-processing, performed by the resonator, and post-processing software, performed by ViDa, for the interpretation of the data. This application is included within the Medical Informatics area, as it provides assistance for clinical decision making. The role of the biomedical engineer is fulfilled by developing a health technology in response to a manifested real-life problem. The tool developed shows promising results achieving a 100% Sensitivity, 73% Specificity, 77% Positive Predictive Value and 100% Negative Predictive Value reported in 21 cases tested. The correct classifications of the tumor’s origin reach 70%, the classification of non-astrocytic lesions achieves 67% of correct classifications in that the gradation of astrocytomas achieves a 57% of gradations that agree with biopsies and 43% of slight errors. It was possible to develop an application of assistance to the diagnosis, which together with others medical tests, will make it possible to sharpen the diagnoses of brain tumors. (authors) [es

  17. Design of a mannequin for spectroscopy magnetic resonance of proton. Preliminary results of its application; Diseno de un maniqui para espectroscopia por resonancia magnetica de proton. resultados preliminares de su aplicacion

    Energy Technology Data Exchange (ETDEWEB)

    Parra Osoirio, V.; Galan Montenegro, P.; Moreno Saiz, C.; Garcia-Alvarez, R.; Arrabal Nunez, S.; Caudepon Moreno, F.; Navarro Guirado, F.; Asensjo Garcia, B.

    2013-07-01

    The proton magnetic resonance spectroscopy is a technique of metabolic Imaging allowing in vivo measurement of the levels of different metabolites. Is under increasing development and has shown an improvement of diagnostic indexes and therapeutic, since it allows: differential diagnosis between injuries, determination of tumor grade of Pre surgical form, determination of the presence of a lesion until it is clear, definition of progress and evaluation of the effects of a treatment. The aim in this work is to have a mannequin that allows analyze and adjust various parameters involved in the spectroscopic process, and establish a quantification of these parameters. (Author)

  18. 7T Proton Magnetic Resonance Spectroscopy of the Anterior Cingulate Cortex in First-Episode Schizophrenia.

    Science.gov (United States)

    Reid, Meredith A; Salibi, Nouha; White, David M; Gawne, Timothy J; Denney, Thomas S; Lahti, Adrienne C

    2018-01-29

    Recent magnetic resonance spectroscopy (MRS) studies suggest that abnormalities of the glutamatergic system in schizophrenia may be dependent on illness stage, medication status, and symptomatology. Glutamatergic metabolites appear to be elevated in the prodromal and early stages of schizophrenia but unchanged or reduced below normal in chronic, medicated patients. However, few of these studies have measured metabolites with high-field 7T MR scanners, which offer higher signal-to-noise ratio and better spectral resolution than 3T scanners and facilitate separation of glutamate and glutamine into distinct signals. In this study, we examined glutamate and other metabolites in the dorsal anterior cingulate cortex (ACC) of first-episode schizophrenia patients. Glutamate and N-acetylaspartate (NAA) were significantly lower in schizophrenia patients vs controls. No differences were observed in levels of glutamine, GABA, or other metabolites. In schizophrenia patients but not controls, GABA was negatively correlated with the total score on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) as well as the immediate memory and language subscales. Our findings suggest that glutamate and NAA reductions in the ACC may be present early in the illness, but additional large-scale studies are needed to confirm these results as well as longitudinal studies to determine the effect of illness progression and treatment. The correlation between GABA and cognitive function suggests that MRS may be an important technique for investigating the neurobiology underlying cognitive deficits in schizophrenia. © The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  19. Proton magnetic resonance spectroscopy of a boron neutron capture therapy 10B-carrier, L-p-boronophenylalanine-fructose complex

    Energy Technology Data Exchange (ETDEWEB)

    Timonen, M.

    2010-07-01

    Boron neutron capture therapy (BNCT) is a radiotherapy that has mainly been used to treat malignant brain tumours, melanomas, and head and neck cancer. In BNCT, the patient receives an intravenous infusion of a 10B-carrier, which accumulates in the tumour area. The tumour is irradiated with epithermal or thermal neutrons, which result in a boron neutron capture reaction that generates heavy particles to damage tumour cells. In Finland, boronophenylalanine fructose (BPA-F) is used as the 10B-carrier. Currently, the drifting of boron from blood to tumour as well as the spatial and temporal accumulation of boron in the brain, are not precisely known. Proton magnetic resonance spectroscopy (1H MRS) could be used for selective BPA-F detection and quantification as aromatic protons of BPA resonate in the spectrum region, which is clear of brain metabolite signals. This study, which included both phantom and in vivo studies, examined the validity of 1H MRS as a tool for BPA detection. In the phantom study, BPA quantification was studied at 1.5 and 3.0 T with single voxel 1H MRS, and at 1.5 T with magnetic resonance imaging (MRSI). The detection limit of BPA was determined in phantom conditions at 1.5 T and 3.0 T using single voxel 1H MRS, and at 1.5 T using MRSI. In phantom conditions, BPA quantification accuracy of +- 5% and +- 15% were achieved with single voxel MRS using external or internal (internal water signal) concentration references, respectively. For MRSI, a quantification accuracy of <5% was obtained using an internal concentration reference (creatine). The detection limits of BPA in phantom conditions for the PRESS sequence were 0.7 (3.0 T) and 1.4 mM (1.5 T) mM with 20 x 20 single voxel MRS, and 1.0 mM with acquisition-weighted MRSI, respectively. In the in vivo study, an MRSI or single voxel MRS or both was performed for ten patients (patients 1-10) on the day of BNCT. Three patients had glioblastoma multiforme (GBM), and five patients had a recurrent or

  20. Analysis of hard exclusive scattering processes of the HERMES recoil experiment

    International Nuclear Information System (INIS)

    Brodski, Irina

    2014-11-01

    Deeply virtual Compton Scattering (DVCS), ep → epγ is the simplest reaction giving indication of generalized parton distributions (GPD) of the nucleon. The DVCS process has the same final state as the Bethe-Heitler process (BH). For this reason the access is taken not through the cross-sections directly but through asymmetries between DVCS events depending on charge and polarization of the 27.6 GeV beam. For the first time the azimuthal asymmetry amplitudes according the charge of the lepton beam are extracted using a kinematically complete reconstruction method at the HERMES experiment. The recoil detector installed in 2006 allows the reconstruction of recoiling protons that completes the measurements of the forward detector to cover almost the complete angle range around the vertex. This approach allows suppressing the background processes by almost a complete magnitude compared to the traditional method using only the information of the forward spectrometer. The analysis of the asymmetries was carried out at different values of the kinematic variables t c' x B and Q 2 to investigate the dependence of these variables. This work pushes the limits of the readability of data and shows which periods have been found to be unstable in the data acquisition. It points out the impact of this finding to previous HERMES publications.

  1. Proton: the particle.

    Science.gov (United States)

    Suit, Herman

    2013-11-01

    The purpose of this article is to review briefly the nature of protons: creation at the Big Bang, abundance, physical characteristics, internal components, and life span. Several particle discoveries by proton as the experimental tool are considered. Protons play important roles in science, medicine, and industry. This article was prompted by my experience in the curative treatment of cancer patients by protons and my interest in the nature of protons as particles. The latter has been stimulated by many discussions with particle physicists and reading related books and journals. Protons in our universe number ≈10(80). Protons were created at 10(-6) -1 second after the Big Bang at ≈1.37 × 10(10) years beforethe present. Proton life span has been experimentally determined to be ≥10(34) years; that is, the age of the universe is 10(-24)th of the minimum life span of a proton. The abundance of the elements is hydrogen, ≈74%; helium, ≈24%; and heavier atoms, ≈2%. Accordingly, protons are the dominant baryonic subatomic particle in the universe because ≈87% are protons. They are in each atom in our universe and thus involved in virtually every activity of matter in the visible universe, including life on our planet. Protons were discovered in 1919. In 1968, they were determined to be composed of even smaller particles, principally quarks and gluons. Protons have been the experimental tool in the discoveries of quarks (charm, bottom, and top), bosons (W(+), W(-), Z(0), and Higgs), antiprotons, and antineutrons. Industrial applications of protons are numerous and important. Additionally, protons are well appreciated in medicine for their role in radiation oncology and in magnetic resonance imaging. Protons are the dominant baryonic subatomic particle in the visible universe, comprising ≈87% of the particle mass. They are present in each atom of our universe and thus a participant in every activity involving matter. Copyright © 2013 Elsevier Inc. All

  2. Proton: The Particle

    Energy Technology Data Exchange (ETDEWEB)

    Suit, Herman

    2013-11-01

    The purpose of this article is to review briefly the nature of protons: creation at the Big Bang, abundance, physical characteristics, internal components, and life span. Several particle discoveries by proton as the experimental tool are considered. Protons play important roles in science, medicine, and industry. This article was prompted by my experience in the curative treatment of cancer patients by protons and my interest in the nature of protons as particles. The latter has been stimulated by many discussions with particle physicists and reading related books and journals. Protons in our universe number ≈10{sup 80}. Protons were created at 10{sup −6} –1 second after the Big Bang at ≈1.37 × 10{sup 10} years beforethe present. Proton life span has been experimentally determined to be ≥10{sup 34} years; that is, the age of the universe is 10{sup −24}th of the minimum life span of a proton. The abundance of the elements is hydrogen, ≈74%; helium, ≈24%; and heavier atoms, ≈2%. Accordingly, protons are the dominant baryonic subatomic particle in the universe because ≈87% are protons. They are in each atom in our universe and thus involved in virtually every activity of matter in the visible universe, including life on our planet. Protons were discovered in 1919. In 1968, they were determined to be composed of even smaller particles, principally quarks and gluons. Protons have been the experimental tool in the discoveries of quarks (charm, bottom, and top), bosons (W{sup +}, W{sup −}, Z{sup 0}, and Higgs), antiprotons, and antineutrons. Industrial applications of protons are numerous and important. Additionally, protons are well appreciated in medicine for their role in radiation oncology and in magnetic resonance imaging. Protons are the dominant baryonic subatomic particle in the visible universe, comprising ≈87% of the particle mass. They are present in each atom of our universe and thus a participant in every activity involving matter.

  3. Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type 1 diabetes mellitus

    International Nuclear Information System (INIS)

    Sarac, K.; Alkan, A.; Baysal, T.; Akinci, A.; Aslan, M.; Oezcan, C.

    2005-01-01

    The metabolite changes in the brains of children with poorly controlled type 1 diabetes mellitus (DM) were investigated by proton magnetic resonance spectroscopy (MRS). A total of 30 subjects and 14 age-matched healthy volunteers underwent single-voxel MRS (TE: 136). The duration of disease, medication, presence of hypoglycaemia episodes and the level of haemoglobin A1C (HbA1C) in the patients were noted. Voxels were placed in the pons, left basal ganglion (LBG) and left posterior parietal white matter (PPWM). N-acetylaspartate (NAA)/creatinine (Cr) and choline (Cho)/Cr ratios were calculated. The average HbA1c level was 11.9±3.4 (8.2-19.4). The average number of keto-acidosis episodes was 1.9±2.2 (0-9) and the average number of daily insulin injections was 2.8±0.97 (2-4). MRS revealed lower NAA/Cr and Cho/Cr ratios in the pons and lower NAA/Cr ratio in the PPWM of patients with DM than in control subjects. No significant correlation was observed between the number of hypoglycaemia episodes and metabolite ratios. Metabolic abnormalities have been observed by MRS in the brain of poorly controlled type 1 DM children. These metabolic changes, in particular in the pons region, include a decrease in NAA, indicating neuronal loss or functional impairment, and likely explanations for a decrease in Cho may be dynamic changes in membrane lipids and/or decreased membrane turnover. (orig.)

  4. Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type 1 diabetes mellitus

    Energy Technology Data Exchange (ETDEWEB)

    Sarac, K.; Alkan, A.; Baysal, T. [Inonu University School of Medicine, Department of Radiology, Malatya (Turkey); Akinci, A.; Aslan, M. [Inonu University School of Medicine, Department of Paediatric Endocrinology, Malatya (Turkey); Oezcan, C. [Inonu University School of Medicine, Department of Neurology, Malatya (Turkey)

    2005-07-01

    The metabolite changes in the brains of children with poorly controlled type 1 diabetes mellitus (DM) were investigated by proton magnetic resonance spectroscopy (MRS). A total of 30 subjects and 14 age-matched healthy volunteers underwent single-voxel MRS (TE: 136). The duration of disease, medication, presence of hypoglycaemia episodes and the level of haemoglobin A1C (HbA1C) in the patients were noted. Voxels were placed in the pons, left basal ganglion (LBG) and left posterior parietal white matter (PPWM). N-acetylaspartate (NAA)/creatinine (Cr) and choline (Cho)/Cr ratios were calculated. The average HbA1c level was 11.9{+-}3.4 (8.2-19.4). The average number of keto-acidosis episodes was 1.9{+-}2.2 (0-9) and the average number of daily insulin injections was 2.8{+-}0.97 (2-4). MRS revealed lower NAA/Cr and Cho/Cr ratios in the pons and lower NAA/Cr ratio in the PPWM of patients with DM than in control subjects. No significant correlation was observed between the number of hypoglycaemia episodes and metabolite ratios. Metabolic abnormalities have been observed by MRS in the brain of poorly controlled type 1 DM children. These metabolic changes, in particular in the pons region, include a decrease in NAA, indicating neuronal loss or functional impairment, and likely explanations for a decrease in Cho may be dynamic changes in membrane lipids and/or decreased membrane turnover. (orig.)

  5. Correlative study of proton magnetic resonance spectroscopy and histopathology in a neonatal piglet model of hypoxic-ischemic encephalopathy

    International Nuclear Information System (INIS)

    Wang Xiaoming; Guo Qiyong; Lin Nan; Ding Changwei; Wang Shuxuan; Chen Liying; Lv Qingjie; Jiang Weiguo

    2005-01-01

    Objective: To evaluate proton magnetic resonance spectroscopy ( 1 H-MRS) in the diagnosis of hypoxic ischemic brain damage (HIBD) in hyperacute period using an animal model. Methods: Twenty-five term piglets at the age of 3 to 7 days were subjected and divided into one control group (n=5) and two experimental groups. 1 H spectrum curve was measured continuously in all cases at 0-6, 20-24, 44-48, and 68-72 h after hypoxic ischemia in frontoparietal region, basal ganglia, and hippocampus. Lac/Cr was calculated. Histopathologic examination included hematoxylin and glial fibrillary acidic protein (GFAP) stain, teminal transferase mediated dUTP-biotin nick- end eosin (HE) stain, labeling (TUNEL) stain, and transmission electron microscope. Results: Lac/Cr in hippocampus region was 0.95 ± 0.88 in control group compared with 5.65 ± 1.93 in model group 1 and 8.93 ± 6.95 in model group 2. Model group 1 showed significantly glial cells swelling in hippocampus region on histopathologic examination. Model group 2 showed neurons and glial cells swelling significantly in hippocampus, and prominent apoptosis was seen in the peripheral neurons and glial cells. Further more Lac/Cr remained high within 72 h. Lac /Cr was 0.41 ± 0.03 in basal ganglia in control group compared with no significant elevation in model group 1 and 13.59 ± 10.23 in model group 2. Model group 1 did not show significant neuron and glial cell pathological changes in basal ganglia. Model group 2 showed obvious glial cell swelling, while neurons changed mildly. Lac/Cr was high within 48 h, and then declined. Lac/Cr in frontoparietal region also increased, but the value was lower than the former two regions. Conclusion: Neurons have an acute energy consumption after hypoxic ischemia, and Lac/Cr reflectes the extent of lesions correctly. (authors)

  6. Metabolic changes in the visual cortex of binocular blindness macaque monkeys: a proton magnetic resonance spectroscopy study.

    Directory of Open Access Journals (Sweden)

    Lingjie Wu

    Full Text Available PURPOSE: To evaluate proton magnetic resonance spectroscopy ((1H-MRS in a study of cross-modal plasticity in the visual cortex of binocular blindness macaque monkeys. MATERIALS AND METHODS: Four healthy neonatal macaque monkeys were randomly divided into 2 groups, with 2 in each group. Optic nerve transection was performed in both monkeys in the experimental group (group B to obtain binocular blindness. Two healthy macaque monkeys served as a control group (group A. After sixteen months post-procedure, (1H-MRS was performed in the visual cortex of all monkeys. We compared the peak areas of NAA, Cr, Cho, Glx and Ins and the ratios of NAA/Cr, Cho/Cr, Glx/Cr and Ins/Cr of each monkey in group B with group A. RESULTS: The peak area of NAA and the NAA/Cr ratio in the visual cortex of monkey 4 in group B were found to be dramatically decreased, the peak area of NAA slightly decreased and the NAA/Cr ratio clearly decreased in visual cortex of monkey 3 in group B than those in group A. The peak area of Ins and the Ins/Cr ratio in the visual cortex of monkey 4 in group B slightly increased. The peak area of Cho and the Cho/Cr ratio in the visual cortex of all monkeys in group B dramatically increased compared with group A. The peak area of Glx in the visual cortex of all monkeys in group B slightly increased compared with group A. CONCLUSIONS: (1H-MRS could detect biochemical and metabolic changes in the visual cortex and therefore this technique can be used to provide valuable information for investigating the mechanisms of cross-modal plasticity of binocular blindness in a macaque monkey model.

  7. Hemodynamic and metabolic characterization of orthotopic rat prostate carcinomas using dynamic MRI and proton magnetic resonance spectroscopy

    International Nuclear Information System (INIS)

    Kiessling, F.; Lichy, M.; Kauczor, H.U.; Schlemmer, H.P.; Grobholz, R.; Heilmann, M.; Meding, J.; Huber, P.E.; Peschke, P.

    2003-01-01

    The aim of this study was the noninvasive characterization of prostate carcinoma orthotopically implanted in rats using Gd-DTPA-assisted dynamic MRI (dMRI) and proton magnetic resonance spectroscopy ( 1 H-MRS). After surgical exposure of the prostate, Dunning R3327 orthotopic prostate carcinoma was induced by injecting cells of the MAT-LyLu subline. Six rats were examined 5 and 14 days after tumor induction with dMRI and 1 H-MRS at 1.5 T. Six tumor-free rats served as controls. Using an open two-compartment model, the parameters A (amplitude) and k ep (exchange rate constants) were calculated from the signal time curves of the dMRI. The relative signal intensities (Cho/Cr) of the resonances of choline (Cho) and the creatine-phosphocreatine complex (Cr) were computed from the MR spectra. Already after 5 days, the tumors in the prostate could be clearly identified based on the decrease in signal intensity to T2w and increase of A and k ep . High Cho/Cr levels and resonances of two lipid fractions (Lip 1 at 0.8-1.5 ppm and Lip 2 at 2.0-2.2 ppm) were observed by MRS in the highly necrotic tumors. The orthotopic rat prostate carcinoma model resembles human prostate carcinoma in regard to MR morphology, dMRI, and 1 H-MRS. The noninvasive characterization of perfusion and metabolism makes a comparative examination of different treatment modalities possible. (orig.) [de

  8. Proton magnetic resonance spectroscopy reveals neuroprotection by oral minocycline in a nonhuman primate model of accelerated NeuroAIDS.

    Directory of Open Access Journals (Sweden)

    Eva-Maria Ratai

    2010-05-01

    Full Text Available Despite the advent of highly active anti-retroviral therapy (HAART, HIV-associated neurocognitive disorders continue to be a significant problem. In efforts to understand and alleviate neurocognitive deficits associated with HIV, we used an accelerated simian immunodeficiency virus (SIV macaque model of NeuroAIDS to test whether minocycline is neuroprotective against lentiviral-induced neuronal injury.Eleven rhesus macaques were infected with SIV, depleted of CD8+ lymphocytes, and studied until eight weeks post inoculation (wpi. Seven animals received daily minocycline orally beginning at 4 wpi. Neuronal integrity was monitored in vivo by proton magnetic resonance spectroscopy and post-mortem by immunohistochemistry for synaptophysin (SYN, microtubule-associated protein 2 (MAP2, and neuronal counts. Astrogliosis and microglial activation were quantified by measuring glial fibrillary acidic protein (GFAP and ionized calcium binding adaptor molecule 1 (IBA-1, respectively. SIV infection followed by CD8+ cell depletion induced a progressive decline in neuronal integrity evidenced by declining N-acetylaspartate/creatine (NAA/Cr, which was arrested with minocycline treatment. The recovery of this ratio was due to increases in NAA, indicating neuronal recovery, and decreases in Cr, likely reflecting downregulation of glial cell activation. SYN, MAP2, and neuronal counts were found to be higher in minocycline-treated animals compared to untreated animals while GFAP and IBA-1 expression were decreased compared to controls. CSF and plasma viral loads were lower in MN-treated animals.In conclusion, oral minocycline alleviates neuronal damage induced by the AIDS virus.

  9. Metabolomics by proton nuclear magnetic resonance spectroscopy of the response to chloroethylnitrosourea reveals drug efficacy and tumor adaptive metabolic pathways.

    Science.gov (United States)

    Morvan, Daniel; Demidem, Aicha

    2007-03-01

    Metabolomics of tumors may allow discovery of tumor biomarkers and metabolic therapeutic targets. Metabolomics by two-dimensional proton high-resolution magic angle spinning nuclear magnetic resonance spectroscopy was applied to investigate metabolite disorders following treatment by chloroethylnitrosourea of murine B16 melanoma (n = 33) and 3LL pulmonary carcinoma (n = 31) in vivo. Treated tumors of both types resumed growth after a delay. Nitrosoureas provoke DNA damage but the metabolic consequences of genotoxic stress are little known yet. Although some differences were observed in the metabolite profile of untreated tumor types, the prominent metabolic features of the response to nitrosourea were common to both. During the growth inhibition phase, there was an accumulation of glucose (more than x10; P < 0.05), glutamine (x3 to 4; P < 0.01), and aspartate (x2 to 5; P < 0.01). This response testified to nucleoside de novo synthesis down-regulation and drug efficacy. However, this phase also involved the increase in alanine (P < 0.001 in B16 melanoma), the decrease in succinate (P < 0.001), and the accumulation of serine-derived metabolites (glycine, phosphoethanolamine, and formate; P < 0.01). This response witnessed the activation of pathways implicated in energy production and resumption of nucleotide de novo synthesis, thus metabolic pathways of DNA repair and adaptation to treatment. During the growth recovery phase, it remained polyunsaturated fatty acid accumulation (x1.5 to 2; P < 0.05) and reduced utilization of glucose compared with glutamine (P < 0.05), a metabolic fingerprint of adaptation. Thus, this study provides the proof of principle that metabolomics of tumor response to an anticancer agent may help discover metabolic pathways of drug efficacy and adaptation to treatment.

  10. Proton Nuclear Magnetic Resonance-Spectroscopic Discrimination of Wines Reflects Genetic Homology of Several Different Grape (V. vinifera L.) Cultivars

    Science.gov (United States)

    Zhu, Yong; Wen, Wen; Zhang, Fengmin; Hardie, Jim W.

    2015-01-01

    Background and Aims Proton nuclear magnetic resonance spectroscopy coupled multivariate analysis (1H NMR-PCA/PLS-DA) is an important tool for the discrimination of wine products. Although 1H NMR has been shown to discriminate wines of different cultivars, a grape genetic component of the discrimination has been inferred only from discrimination of cultivars of undefined genetic homology and in the presence of many confounding environmental factors. We aimed to confirm the influence of grape genotypes in the absence of those factors. Methods and Results We applied 1H NMR-PCA/PLS-DA and hierarchical cluster analysis (HCA) to wines from five, variously genetically-related grapevine (V. vinifera) cultivars; all grown similarly on the same site and vinified similarly. We also compared the semi-quantitative profiles of the discriminant metabolites of each cultivar with previously reported chemical analyses. The cultivars were clearly distinguishable and there was a general correlation between their grouping and their genetic homology as revealed by recent genomic studies. Between cultivars, the relative amounts of several of the cultivar-related discriminant metabolites conformed closely with reported chemical analyses. Conclusions Differences in grape-derived metabolites associated with genetic differences alone are a major source of 1H NMR-based discrimination of wines and 1H NMR has the capacity to discriminate between very closely related cultivars. Significance of the Study The study confirms that genetic variation among grape cultivars alone can account for the discrimination of wine by 1H NMR-PCA/PLS and indicates that 1H NMR spectra of wine of single grape cultivars may in future be used in tandem with hierarchical cluster analysis to elucidate genetic lineages and metabolomic relations of grapevine cultivars. In the absence of genetic information, for example, where predecessor varieties are no longer extant, this may be a particularly useful approach. PMID

  11. Binge Toluene Exposure Alters Glutamate, Glutamine and GABA in the Adolescent Rat Brain as Measured by Proton Magnetic Resonance Spectroscopy*

    Science.gov (United States)

    Perrine, Shane A.; O'Leary-Moore, Shonagh K.; Galloway, Matthew P.; Hannigan, John H.; Bowen, Scott E.

    2010-01-01

    Despite the high incidence of toluene abuse in adolescents, little is known regarding the effect of binge exposure on neurochemical profiles during this developmental stage. In the current study, the effects of binge toluene exposure during adolescence on neurotransmitter levels were determined using high-resolution proton magnetic resonance spectroscopy ex vivo at 11.7 T. Adolescent male Sprague-Dawley rats were exposed to toluene (0, 8,000 , or 12,000 ppm) for 15 min twice daily from postnatal day 28 (P28) through P34 and then euthanized either one or seven days later (on P35 or P42) to assess glutamate, glutamine, and GABA levels in intact tissue punches from the medial prefrontal cortex (mPFC), anterior striatum and hippocampus. In the mPFC, toluene reduced glutamate one day after exposure, with no effect on GABA, while after seven days, glutamate was no longer affected but there was an increase in GABA levels. In the hippocampus, neither GABA nor glutamate was altered one day after exposure, whereas seven days after exposure, increases were observed in GABA and glutamate. Striatal glutamate and GABA levels measured after either one or seven days were not altered after toluene exposure. These findings show that one week of binge toluene inhalation selectively alters these neurotransmitters in the mPFC and hippocampus in adolescent rats, and that some of these effects endure at least one week after the exposure. The results suggest that age-dependent, differential neurochemical responses to toluene may contribute to the unique behavioral patterns associated with drug abuse among older children and young teens. PMID:21126832

  12. Amide Proton Transfer Magnetic Resonance Imaging of Alzheimer′s Disease at 3.0 Tesla: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Rui Wang

    2015-01-01

    Full Text Available Background: Amide proton transfer (APT imaging has recently emerged as an important contrast mechanism for magnetic resonance imaging (MRI in the field of molecular and cellular imaging. The aim of this study was to evaluate the feasibility of APT imaging to detect cerebral abnormality in patients with Alzheimer′s disease (AD at 3.0 Tesla. Methods: Twenty AD patients (9 men and 11 women; age range, 67-83 years and 20 age-matched normal controls (11 men and 9 women; age range, 63-82 years underwent APT and traditional MRI examination on a 3.0 Tesla MRI system. The magnetic resonance ratio asymmetry (MTR asym values at 3.5 ppm of bilateral hippocampi (Hc, temporal white matter regions, occipital white matter regions, and cerebral peduncles were measured on oblique axial APT images. MTR asym (3.5 ppm values of the cerebral structures between AD patients and control subjects were compared with independent samples t-test. Controlling for age, partial correlation analysis was used to investigate the associations between mini-mental state examination (MMSE and the various MRI measures among AD patients. Results: Compared with normal controls, MTR asym (3.5 ppm values of bilateral Hc were significantly increased in AD patients (right 1.24% ± 0.21% vs. 0.83% ± 0.19%, left 1.18% ± 0.18% vs. 0.80%± 0.17%, t = 3.039, 3.328, P = 0.004, 0.002, respectively. MTR asym (3.5 ppm values of bilateral Hc were significantly negatively correlated with MMSE (right r = −0.559, P = 0.013; left r = −0.461, P = 0.047. Conclusions: Increased MTR asym (3.5 ppm values of bilateral Hc in AD patients and its strong correlations with MMSE suggest that APT imaging could potentially provide imaging biomarkers for the noninvasive molecular diagnosis of AD.

  13. Multimodality imaging using proton magnetic resonance spectroscopic imaging and 18F-fluorodeoxyglucose-positron emission tomography in local prostate cancer

    Science.gov (United States)

    Shukla-Dave, Amita; Wassberg, Cecilia; Pucar, Darko; Schöder, Heiko; Goldman, Debra A; Mazaheri, Yousef; Reuter, Victor E; Eastham, James; Scardino, Peter T; Hricak, Hedvig

    2017-01-01

    AIM To assess the relationship using multimodality imaging between intermediary citrate/choline metabolism as seen on proton magnetic resonance spectroscopic imaging (1H-MRSI) and glycolysis as observed on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in prostate cancer (PCa) patients. METHODS The study included 22 patients with local PCa who were referred for endorectal magnetic resonance imaging/1H-MRSI (April 2002 to July 2007) and 18F-FDG-PET/CT and then underwent prostatectomy as primary or salvage treatment. Whole-mount step-section pathology was used as the standard of reference. We assessed the relationships between PET parameters [standardized uptake value (SUVmax and SUVmean)] and MRSI parameters [choline + creatine/citrate (CC/Cmax and CC/Cmean) and total number of suspicious voxels] using spearman’s rank correlation, and the relationships of PET and 1H-MRSI index lesion parameters to surgical Gleason score. RESULTS Abnormal intermediary metabolism on 1H-MRSI was present in 21/22 patients, while abnormal glycolysis on 18F-FDG-PET/CT was detected in only 3/22 patients. Specifically, index tumor localization rates were 0.95 (95%CI: 0.77-1.00) for 1H-MRSI and 0.14 (95%CI: 0.03-0.35) for 18F-FDG-PET/CT. Spearman rank correlations indicated little relationship (ρ = -0.36-0.28) between 1H-MRSI parameters and 18F-FDG-PET/CT parameters. Both the total number of suspicious voxels (ρ = 0.55, P = 0.0099) and the SUVmax (ρ = 0.46, P = 0.0366) correlated weakly with the Gleason score. No significant relationship was found between the CC/Cmax, CC/Cmean or SUVmean and the Gleason score (P = 0.15-0.79). CONCLUSION The concentration of intermediary metabolites detected by 1H MRSI and glycolytic flux measured 18F-FDG PET show little correlation. Furthermore, only few tumors were FDG avid on PET, possibly because increased glycolysis represents a late and rather ominous event in the progression of PCa. PMID:28396727

  14. Serial changes in metabolism and histology in the cold-injury trauma rat brain model. Proton magnetic resonance imaging and spectroscopy study

    Energy Technology Data Exchange (ETDEWEB)

    Kamada, Kyousuke; Houkin, Kiyohiro; Hida, Kazutoshi; Iwasaki, Yoshinobu; Abe, Hiroshi [Hokkaido Univ., Sapporo (Japan). School of Medicine

    1995-01-01

    The serial changes in metabolism and histology during the first 24 hours in the cold-injury trauma rat brain model were investigated by proton magnetic resonance (MR) imaging and high-resolution proton MR spectroscopy. Edema developed extensively via the corpus callosum in the ipsi- and contralateral hemispheres during observation as shown by gradually increased signal intensity on proton MR images. Proton MR spectroscopy showed increased levels of acetate (Ace), lactate (Lac), and glutamine (Glmi) 1 hour after lesion formation. The elevated Glmi level slightly decreased, the level of alanine (Ala) increased substantially, and that of N-acetyl-aspartate (NAA) decreased markedly after 24 hours. Increased Lac, Ace, and Ala might reflect anaerobic glycolysis associated with mitochondrial dysfunction, while decreased Glmi and NAA reveal brain tissue breakdown. The relationship between brain edema and tissue viability can be analyzed in detail using this simple traumatic model and MR techniques which will be useful in the development of therapeutic agents for brain injury. (author).

  15. Graphene oxide-Fe{sub 3}O{sub 4} nanoparticle composite with high transverse proton relaxivity value for magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Venkatesha, N.; Srivastava, Chandan, E-mail: csrivastava@materials.iisc.ernet.in [Department of Materials Engineering, Indian Institute of Science, Bangalore 560012 (India); Poojar, Pavan; Geethanath, Sairam [Medical Imaging Research Centre, Dayananda Sagar Institutions, Bangalore 560078 (India); Qurishi, Yasrib [Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012 (India)

    2015-04-21

    The potential of graphene oxide–Fe{sub 3}O{sub 4} nanoparticle (GO-Fe{sub 3}O{sub 4}) composite as an image contrast enhancing material in magnetic resonance imaging has been investigated. Proton relaxivity values were obtained in three different homogeneous dispersions of GO-Fe{sub 3}O{sub 4} composites synthesized by precipitating Fe{sub 3}O{sub 4} nanoparticles in three different reaction mixtures containing 0.01 g, 0.1 g, and 0.2 g of graphene oxide. A noticeable difference in proton relaxivity values was observed between the three cases. A comprehensive structural and magnetic characterization revealed discrete differences in the extent of reduction of the graphene oxide and spacing between the graphene oxide sheets in the three composites. The GO-Fe{sub 3}O{sub 4} composite framework that contained graphene oxide with least extent of reduction of the carboxyl groups and largest spacing between the graphene oxide sheets provided the optimum structure for yielding a very high transverse proton relaxivity value. It was found that the GO-Fe{sub 3}O{sub 4} composites possessed good biocompatibility with normal cell lines, whereas they exhibited considerable toxicity towards breast cancer cells.

  16. Mechanical-property changes of structural composite materials after low-temperature proton irradiation: Implications for use in SSC magnet systems

    International Nuclear Information System (INIS)

    Morena, J.; Snead, C.L. Jr.; Czajkowski, C.; Skaritka, J.

    1993-01-01

    Longterm physical, mechanical, electrical, and other properties of advanced composites, plastics, and other polymer materials are greatly affected by high-energy proton, neutron, electron, and gamma radiation. The effects of high-energy particles on materials is a critical design parameter to consider when choosing polymeric structural, nonstructural, and elastomeric matrix resin systems. Polymer materials used for filled resins, laminates, seals, gaskets, coatings, insulation and other nonmetallic components must be chosen carefully, and reference data viewed with caution. Most reference data collected in the high-energy physics community to date reflects material property degradation using other than proton irradiations. In most instances, the data were collected for room-temperature irradiations, not 4.2 K or other cryogenic temperatures, and at doses less than 10 8 --10 9 Rad. Energetic proton (and the accompanying spallation-product particles) provide good simulation fidelity to the expected radiation fields predicted for the cold-mass regions of the SSC magnets, especially the corrector magnets. The authors present here results for some structural composite materials which were part of a larger irradiation-characterization of polymeric materials for SSC applications

  17. Two-processor automatized system to control fast measurements of the magnetic field index of the JINR 10 GeV proton synchrotron

    International Nuclear Information System (INIS)

    Chernykh, E.V.

    1981-01-01

    A two-processor system comprizing a hard-wired module and ES-1010 computer to control measurements of the magnetic field index of the JINR 10 GeV proton synchrotron is described. The system comprises the control module, a computer interface and a parallel branch driver residing in CAMAC system crate. The control module controls analogue multiplexer and analogue-to-digital converter through their front panels and writes down the information into a buffer memory module through the CAMAC highway. The computer controls the system, reads the information into core memory, writes down it on a magnetic tape, processes it and outputs n=f(r) plots on TV monitor and printer. The system provides the measurement up to 100 points during a magnetic field rise and minimal time of measurement 50 μs [ru

  18. Submillisecond elastic recoil reveals molecular origins of fibrin fiber mechanics.

    Science.gov (United States)

    Hudson, Nathan E; Ding, Feng; Bucay, Igal; O'Brien, E Timothy; Gorkun, Oleg V; Superfine, Richard; Lord, Susan T; Dokholyan, Nikolay V; Falvo, Michael R

    2013-06-18

    Fibrin fibers form the structural scaffold of blood clots. Thus, their mechanical properties are of central importance to understanding hemostasis and thrombotic disease. Recent studies have revealed that fibrin fibers are elastomeric despite their high degree of molecular ordering. These results have inspired a variety of molecular models for fibrin's elasticity, ranging from reversible protein unfolding to rubber-like elasticity. An important property that has not been explored is the timescale of elastic recoil, a parameter that is critical for fibrin's mechanical function and places a temporal constraint on molecular models of fiber elasticity. Using high-frame-rate imaging and atomic force microscopy-based nanomanipulation, we measured the recoil dynamics of individual fibrin fibers and found that the recoil was orders of magnitude faster than anticipated from models involving protein refolding. We also performed steered discrete molecular-dynamics simulations to investigate the molecular origins of the observed recoil. Our results point to the unstructured αC regions of the otherwise structured fibrin molecule as being responsible for the elastic recoil of the fibers. Copyright © 2013 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  19. Submillisecond Elastic Recoil Reveals Molecular Origins of Fibrin Fiber Mechanics

    Science.gov (United States)

    Hudson, Nathan E.; Ding, Feng; Bucay, Igal; O’Brien, E. Timothy; Gorkun, Oleg V.; Superfine, Richard; Lord, Susan T.; Dokholyan, Nikolay V.; Falvo, Michael R.

    2013-01-01

    Fibrin fibers form the structural scaffold of blood clots. Thus, their mechanical properties are of central importance to understanding hemostasis and thrombotic disease. Recent studies have revealed that fibrin fibers are elastomeric despite their high degree of molecular ordering. These results have inspired a variety of molecular models for fibrin’s elasticity, ranging from reversible protein unfolding to rubber-like elasticity. An important property that has not been explored is the timescale of elastic recoil, a parameter that is critical for fibrin’s mechanical function and places a temporal constraint on molecular models of fiber elasticity. Using high-frame-rate imaging and atomic force microscopy-based nanomanipulation, we measured the recoil dynamics of individual fibrin fibers and found that the recoil was orders of magnitude faster than anticipated from models involving protein refolding. We also performed steered discrete molecular-dynamics simulations to investigate the molecular origins of the observed recoil. Our results point to the unstructured αC regions of the otherwise structured fibrin molecule as being responsible for the elastic recoil of the fibers. PMID:23790375

  20. Recoil polarization measurements in $\\pi^{0}$ electroproduction at the peak of the Delta (1232)

    CERN Document Server

    Sarty, A J

    2001-01-01

    This talk presents a status report, along with some preliminary/on line results, from the Thomas Jefferson National Accelerator Facility (JLab) experiment E91011 which was performed in Hall A at JLab during the summer of 2000. The experiment measured angular distributions for the differential cross section and recoil proton polarizations in the reaction p(e, e'p) pi /sup 0/. Kinematics were chosen to be centered at a CMS energy of W=1232 MeV, and a squared four momentum transfer of Q/sup 2/=1.0 (GeV/c)/sup 2/. The primary objectives of the experiment are to isolate contributions from the resonant quadrupole N to Delta , multipole S/sub 1+/, and to clarify the role of other, small nonresonant multipole contributions to the reaction. Details of the experiment itself will be given, along with sample spectra illustrating the quality and coverage of the data obtained. (10 refs) .

  1. Particle unstable excited states in /sup 9/Be influence of beta recoil and width on delayed particle spectra

    CERN Document Server

    Nyman, G H; Jonson, B; Kratz, K L; Larsson, P O; Mattsson, S; Ziegert, W

    1981-01-01

    The light nucleus /sup 9/Be has been studied through the emission of beta-delayed neutrons and alpha particles from /sup 9/Li. The activity is produced at the ISOLDE facility in fragmentation reactions induced either by 600 MeV proton or 910 MeV /sup 3/He beams from the CERN Synchro-cyclotron. After mass separation neutron spectra are recorded using /sup 3/He-filled proportional counters, while surface barrier detectors are used for the spectroscopy of alpha particles. Effects on the spectrum shape induced by recoil and polarization phenomena as well as large widths of the intermediate states are discussed. (14 refs).

  2. The Differential Cross Section and Λ Recoil Polarization from γδ -> Κ0(ρ)

    Energy Technology Data Exchange (ETDEWEB)

    Compton, Nicholas [Ohio Univ., Athens, OH (United States); Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2017-04-30

    Presented is the analysis of the differential cross section and Λ recoil polarization from the reaction γδ -> Κ0(ρ). This work measured these observables over beam energies from 0.90 GeV to 3.0 GeV. These measurements are the first in this channel to cover such a wide range of energies. The data were taken using the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Laboratory (JLAB) along with a tagged photon beam. This analysis was completed by identifying events of interest that decayed into the final state topology of π-π+,π-&rho'(ρ). Through conservation of energy and momentum, the Κ0, Λ and missing mass of the spectator proton were reconstructed. Utilizing the same analysis techniques, the observables were measured on two different experiments with good agreement. Photoproduction of strange mesons from the neutron are difficult to measure, consequently there are only a few measurements of this kind. Despite that, these reactions supply essential complementary data to those on the proton. The differential cross sections and the recoil polarization extracted, span the region where new nucleon resonances have been found from studies of the reaction γρ -> Κ+Λ. Comparisons between the Κ+Λ and Κ0Λ cross section demonstrate that possible interference terms near 1900 MeV are less pronounced in the latter. This unexpected result inspired a partial wave analyses (PWA) to be fitted to the data. The fit solution shows that this measurement fostered an improvement on the knowledge of observed resonance parameters, necessary to understanding these excited states. The study of nucleon resonances is a key motivating factor since the resonance masses can be calculated from the theory of the strong nuclear force, called quantum chromodynamics, or QCD.

  3. Shallow doping of gallium arsenide by recoil implantation

    International Nuclear Information System (INIS)

    Sadana, D.K.; Souza, J.P. de; Rutz, R.F.; Cardone, F.; Norcott, M.H.

    1989-01-01

    Si atoms were recoil-implanted into GaAs by bombarding neutral (As + ) or dopant (Si + ) ions through a thin Si cap. The bombarded samples were subsequently rapid thermally or furnace annealed at 815-1000 degree C in Ar or arsine ambient. The presence of the recoiled Si in GaAs and resulting n + -doping was confirmed by secondary ion mass spectrometry and Hall measurements. It was found that sheet resistance of 19 cm 3 and the annealing temperature was > 850 degree C. The present electrical data show that the recoil implant method is a viable alternative to direct shallow implant for n + doping of GaAs. 7 refs., 3 figs., 1 tab

  4. Recoil effects of neutron-irradiated metal salts

    International Nuclear Information System (INIS)

    Lee, B.H.

    1980-01-01

    The distribution of sup(56)Mn and sup(38)Cl recoil species following radiative neutron capture permanganates, chlorates and perchlorates has been investigated by using ion-exchange chromatography method. The whole of the sup(56)Mn radioactivity in permanganates appeared in two valence states, the sup(38)Cl radioactivity in chlorates in two valence states and also the sup(38)Cl radioactivity in perchlorates in three valence states. Recoil energy was calculated. The internal conversion of sup(38m)Cl isomer transition affects the retention value. The greater the radii of the cation, the higher is the probability of the recoil atom breaking through the secondary cage. In ammonium salt, the ammonium ion behaves as a reducing agent. Crystal structures with their greater free space have shown by retention. (Author)

  5. Recoil release of fission products from nuclear fuel

    International Nuclear Information System (INIS)

    Wise, C.

    1985-01-01

    An analytical approximation is developed for calculating recoil release from nuclear fuel into gas filled interspaces. This expression is evaluated for a number of interspace geometries and shown to be generally accurate to within about 10% by comparison with numerical calculations. The results are applied to situations of physical interest and it is demonstrated that recoil can be important when modelling fission product release from low temperature CAGR pin failures. Furthermore, recoil can contribute significantly in experiments on low temperature fission product release, particularly where oxidation enhancement of this release is measured by exposing the fuel to CO 2 . The calculations presented here are one way of allowing for this, other methods are suggested. (orig.)

  6. Time-of-flight scattering and recoiling spectrometry

    International Nuclear Information System (INIS)

    Rabalais, J.W.

    1991-01-01

    Ion scattering and recoiling spectrometry consists of directing a collimated beam of monoenergetic ions towards a surface and measuring the flux of scattered and recoiled particles from this surface. When the neutral plus ion flux is velocity selected by measuring the flight times from the sample to the detector, the technique is called time-of-flight scattering and recoiling spectrometry (TOF-SARS). TOF-SARS is capable of (1) surface elemental analysis by applying classical mechanics to the velocities of the particles, (2) surface structural analysis by monitoring the angular anisotropies in the particle flux, and (3) ion-surface electron exchange probabilities by analysis of the ion/neutral fractions in the particle flux. Examples of these three areas are presented herein

  7. Study of the magnetic characteristics of ferrites with a view to their application in a proton synchrotron; Etudes des caracteristiques magnetiques des ferrites en vue de leur application dans un synchrotron a protons

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, K C [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1966-10-01

    In this report magnetic properties of some Ni Zn ferrites available in France are investigated for the purpose of their use in accelerating cavities of proton synchrotron. An attempt is made to measure permeability and quality factor of ferrite versus various physical parameters such as frequency F, the induction B, the magnetic bias field Hp and the temperature, the investigation ranges being: F {<=} 40 Mc/s; B {<=} 10{sup -2} Tesla; Hp {<=} 5000 AT/m; T {<=} 100 C. The measurements were carried out with the one hand, conventional impedance bridge (Q-meter, RX-meter) and on the other hand, with resonating method using an inductive ferrite loaded cavity in parallel with an external capacity. The latter method is of particular interest for the measurements in function of induction and magnetic bias field. (author) [French] Ce travail consiste a etudier les proprietes magnetiques d'un certain nombre de ferrites de Ni Zn disponibles sur le marche francais en vue de leur utilisation dans les cavites acceleratrices d'un synchrotron a protons. On se propose de mesurer la permeabilite et le facteur de qualite du ferrite en fonction de divers parametres physiques tels que la frequence F, l'induction B, le champ magnetique de polarisation Hp et la temperature T, avec: F {<=} 40 Mc/s; B {<=} 10{sup -2} Tesla; Hp {<=} 5000 AT/m; T {<=} 100 C. On effectue les mesures d'une part a l'aide des ponts d'impedance classiques (Q-metre, RX-metre) et d'autre part par la methode du resonateur qui consiste a mettre en parallele une cavite inductive chargee de ferrite et une capacite exterieure. Cette derniere methode est particulierement interessante pour les mesures en fonction de l'induction et du champ magnetique polarisant. (auteur)

  8. RECOILING MASSIVE BLACK HOLES IN GAS-RICH GALAXY MERGERS

    International Nuclear Information System (INIS)

    Guedes, Javiera; Madau, Piero; Mayer, Lucio; Callegari, Simone

    2011-01-01

    The asymmetric emission of gravitational waves produced during the coalescence of a massive black hole (MBH) binary imparts a velocity 'kick' to the system that can displace the hole from the center of its host. Here, we study the trajectories and observability of MBHs recoiling in three (one major, two minor) gas-rich galaxy merger remnants that were previously simulated at high resolution, and in which the pairing of the MBHs had been shown to be successful. We run new simulations of MBHs recoiling in the major merger remnant with Mach numbers in the range 1≤M≤6 and use simulation data to construct a semi-analytical model for the orbital evolution of MBHs in gas-rich systems. We show the following. (1) In major merger remnants the energy deposited by the moving hole into the rotationally supported, turbulent medium makes a negligible contribution to the thermodynamics of the gas. This contribution becomes significant in minor merger remnants, potentially allowing for an electromagnetic signature of MBH recoil. (2) In major merger remnants, the combination of both deeper central potential well and drag from high-density gas confines even MBHs with kick velocities as high as 1200 km s -1 within 1 kpc from the host's center. (3) Kinematically offset nuclei may be observable for timescales of a few Myr in major merger remnants in the case of recoil velocities in the range 700-1000 km s -1 . (4) In minor merger remnants the effect of gas drag is weaker, and MBHs with recoil speeds in the range 300-600 km s -1 will wander through the host halo for longer timescales. When accounting for the probability distribution of kick velocities, however, we find that the likelihood of observing recoiling MBHs in gas-rich galaxy mergers is very low even in the best-case scenario.

  9. Detection of exclusive reactions in the Hermes Recoil Fiber Tracker

    International Nuclear Information System (INIS)

    Keri, Tibor

    2008-08-01

    (Recoil Detector) with an unpolarized target at this position. This detector consists of the Silicon Strip Detector, the SFT (Scintillating Fiber Tracker), the Photon Detector and is surrounded by a 1T superconducting magnet. It provides several space points for tracking and thus momentum reconstruction. The energy deposition in the various detectors is used to achieve particle identification. The main part of the thesis work was the implementation of the SFT and the RD readout system. Before the installation of the RD a series of test runs were carried out to proof the concept of the detector, to measure the internal alignment and to prepare the installation. These test runs for the SFT are described and major results are shown. Furthermore a preliminary analysis of the latest data 06d/06d0 was carried out to show the performance of the installed Recoil Detector in combination with the HERMES forward spectrometer. (orig.)

  10. Detection of exclusive reactions in the Hermes Recoil Fiber Tracker

    Energy Technology Data Exchange (ETDEWEB)

    Keri, Tibor

    2008-08-15

    the RD (Recoil Detector) with an unpolarized target at this position. This detector consists of the Silicon Strip Detector, the SFT (Scintillating Fiber Tracker), the Photon Detector and is surrounded by a 1T superconducting magnet. It provides several space points for tracking and thus momentum reconstruction. The energy deposition in the various detectors is used to achieve particle identification. The main part of the thesis work was the implementation of the SFT and the RD readout system. Before the installation of the RD a series of test runs were carried out to proof the concept of the detector, to measure the internal alignment and to prepare the installation. These test runs for the SFT are described and major results are shown. Furthermore a preliminary analysis of the latest data 06d/06d0 was carried out to show the performance of the installed Recoil Detector in combination with the HERMES forward spectrometer. (orig.)

  11. Computer-aided method for recognition of proton track in nuclear emulsion

    International Nuclear Information System (INIS)

    Ruan Jinlu; Li Hongyun; Song Jiwen; Zhang Jianfu; Chen Liang; Zhang Zhongbing; Liu Jinliang

    2014-01-01

    In order to overcome the shortcomings of the manual method for proton-recoil track recognition in nuclear emulsions, a computer-aided track recognition method was studied. In this method, image sequences captured by a microscope system were processed through image convolution with composite filters, binarization by multi thresholds, track grains clustering and redundant grains removing to recognize the track grains in the image sequences. Then the proton-recoil tracks were reconstructed from the recognized track grains through track reconstruction. The proton-recoil tracks in the nuclear emulsion irradiated by the neutron beam at energy of 14.9 MeV were recognized by the computer-aided method. The results show that proton-recoil tracks reconstructed by this method consist well with those reconstructed by the manual method. This compute-raided track recognition method lays an important technical foundation of developments of a proton-recoil track automatic recognition system and applications of nuclear emulsions in pulsed neutron spectrum measurement. (authors)

  12. Drift tube with an electro-quadrupole magnet made with a conventional enamel wire for the proton engineering frontier project drift tube linac

    Science.gov (United States)

    Kim, Y. H.; Kwon, H. J.; Cho, Y. S.

    2006-12-01

    The proton engineering frontier project (PEFP) drift tube linac (DTL) chose the new type of electro-quadrupole magnet (EQM) using an enameled wire for a drift tube. By using this kind of EQM, we could simplify the drift tube structure. We verified the structural stability and thermal stability of this drift tube structure through a computational analysis and a simple experiment. We also verified the stability of the enameled wire regarding corrosion through a long period test of about 1 year. It was concluded that the design and fabrication of the drift tube and the EQM were successful.

  13. Drift tube with an electro-quadrupole magnet made with a conventional enamel wire for the proton engineering frontier project drift tube linac

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Y.H. [PEFP, KAERI, DaeJeon (Korea, Republic of)]. E-mail: yhkim72@kaeri.re.kr; Kwon, H.J. [PEFP, KAERI, DaeJeon (Korea, Republic of); Cho, Y.S. [PEFP, KAERI, DaeJeon (Korea, Republic of)

    2006-12-21

    The proton engineering frontier project (PEFP) drift tube linac (DTL) chose the new type of electro-quadrupole magnet (EQM) using an enameled wire for a drift tube. By using this kind of EQM, we could simplify the drift tube structure. We verified the structural stability and thermal stability of this drift tube structure through a computational analysis and a simple experiment. We also verified the stability of the enameled wire regarding corrosion through a long period test of about 1 year. It was concluded that the design and fabrication of the drift tube and the EQM were successful.

  14. Drift tube with an electro-quadrupole magnet made with a conventional enamel wire for the proton engineering frontier project drift tube linac

    International Nuclear Information System (INIS)

    Kim, Y.H.; Kwon, H.J.; Cho, Y.S.

    2006-01-01

    The proton engineering frontier project (PEFP) drift tube linac (DTL) chose the new type of electro-quadrupole magnet (EQM) using an enameled wire for a drift tube. By using this kind of EQM, we could simplify the drift tube structure. We verified the structural stability and thermal stability of this drift tube structure through a computational analysis and a simple experiment. We also verified the stability of the enameled wire regarding corrosion through a long period test of about 1 year. It was concluded that the design and fabrication of the drift tube and the EQM were successful

  15. Prognostic value of proton magnetic resonance spectroscopy findings in near drowning patients: reversibility of the early metabolite abnormalities relates with a good outcome

    Energy Technology Data Exchange (ETDEWEB)

    Aragao, Maria de Fatima Vasco; Law, Meng; Prola Netto, Joao; Naidich, Thomas [Mount Sinai School of Medicine, New York, NY (United States). Dept. of Radiology], e-mail: aragao@truenet.com; Valenca, Marcelo Moraes [Federal University of Pernambuco (UFPE), Recife, PE (Brazil). Dept. of Neuropsychiatry and Behavioral Studies

    2009-03-15

    In two children with near drowning hypoxic encephalopathy and normal-appearing structural MRI, acute proton magnetic resonance spectroscopy ({sup 1}H MRS) showed biochemical alterations that correctly indicated prognosis and helped to guide management decisions. Elevation of the lipid-lactate and glutamine-glutamate peaks, on the early (72 hour) {sup 1}H MRS, predicts a poor prognosis. Absence of lipid-lactate and glutamine-glutamate peaks on the early {sup 1}H MRS and reversibility of early mild metabolite abnormalities on follow up examination relates with good outcome. (author)

  16. Prognostic value of proton magnetic resonance spectroscopy findings in near drowning patients: reversibility of the early metabolite abnormalities relates with a good outcome

    International Nuclear Information System (INIS)

    Aragao, Maria de Fatima Vasco; Law, Meng; Prola Netto, Joao; Naidich, Thomas; Valenca, Marcelo Moraes

    2009-01-01

    In two children with near drowning hypoxic encephalopathy and normal-appearing structural MRI, acute proton magnetic resonance spectroscopy ( 1 H MRS) showed biochemical alterations that correctly indicated prognosis and helped to guide management decisions. Elevation of the lipid-lactate and glutamine-glutamate peaks, on the early (72 hour) 1 H MRS, predicts a poor prognosis. Absence of lipid-lactate and glutamine-glutamate peaks on the early 1 H MRS and reversibility of early mild metabolite abnormalities on follow up examination relates with good outcome. (author)

  17. Reorientations in [Mg(H2O)6](CLO4)2 studied by the proton magnetic resonance and the quasielastic neutron scattering methods

    International Nuclear Information System (INIS)

    Svare, I.; Fimland, B.O.; Janik, J.A.; Janik, J.M.; Mikuli, E.; Migdal-Mikuli, A.

    1980-01-01

    Proton magnetic relaxation measurements carried out for [Mg(H 2 O)XL6](CLO 4 ) 2 revealed two processes responsible for T 1 vs temperature dependence: one connected with H 2 O 180deg flips about the symmetry axes and second connected with a tumbling of the complex cation. Quasielastic neutron scattering measurements gave another evidence of H 2 O 180deg flips. The reorientational corelation times, which in the 273 K - 325 K region are of the order of picoseconds, as derived from NMR coincide perfectly well with those derived from QNS. (author)

  18. Early time course of N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline in the brain after acute stroke. A proton magnetic resonance spectroscopy study

    DEFF Research Database (Denmark)

    Gideon, P; Henriksen, O; Sperling, B

    1992-01-01

    BACKGROUND AND PURPOSE: The early time course after acute stroke of cerebral N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline was studied in vivo by means of localized water-suppressed proton magnetic resonance spectroscopy. METHODS: Eight patients with acute stroke......, with the loss appearing to occur between 6 and 24 hours after the stroke incident. The reduction in N-acetylaspartate content was greater in the central part than in the peripheral part of the infarcted area. Creatine and phosphocreatine were also reduced in the infarcted area, whereas no significant change...

  19. Proton magnetic resonance study of the influence of chemical modification, mutation, quaternary state, and ligation state on dynamic stability of the heme pocket in hemoglobin as reflected in the exchange of the proximal histidyl ring labile proton

    International Nuclear Information System (INIS)

    Han, K.H.; La Mar, G.N.; Nagai, K.

    1989-01-01

    Proton nuclear magnetic resonance spectroscopy has been utilized to investigate the rates of exchange with deuterium of the proximal histidyl ring protons in a series of chemically modified and mutated forms of Hb A. Differences in rates of exchange are related to differences in the stability of the deformed or partially unfolded intermediates from which exchange with bulk solvent takes place. Each modified/mutated Hb exhibited kinetic subunit heterogeneity in the reduced ferrous state, with the alpha subunit exhibiting faster exchange than the beta subunit. Modification or mutation resulted in significant increases in the His F8 ring NH exchange rates primarily for the affected subunit and only if the modification/mutation occurs at the allosterically important alpha 1 beta 2 subunit interface. Moreover, this enhancement in exchange rate is observed primarily in that quaternary state of the modified/mutated Hb in which the modified/substituted residue makes the intersubunit contact. This confirms the importance of allosteric constraints in determining the dynamic properties of the heme pocket. Using modified or mutated Hbs that can switch between the alternate quaternary states within a given ligation state or ligate within a given quaternary state, we show that the major portion of the enhanced exchange rate in R-state oxy Hb relative to T-state deoxy Hb originates from the quaternary switch rather than from ligation. However, solely ligation effects are not negligible. The exchange rates of the His F8 ring labile protons increase dramatically upon oxidizing the iron to the ferric state, and both the subunit kinetic heterogeneity and the allosteric sensitivity to the quaternary state are essentially abolished

  20. Direct Measurement of Photon Recoil from a Levitated Nanoparticle

    Science.gov (United States)

    Jain, Vijay; Gieseler, Jan; Moritz, Clemens; Dellago, Christoph; Quidant, Romain; Novotny, Lukas

    2016-06-01

    The momentum transfer between a photon and an object defines a fundamental limit for the precision with which the object can be measured. If the object oscillates at a frequency Ω0 , this measurement backaction adds quanta ℏΩ0 to the oscillator's energy at a rate Γrecoil, a process called photon recoil heating, and sets bounds to coherence times in cavity optomechanical systems. Here, we use an optically levitated nanoparticle in ultrahigh vacuum to directly measure Γrecoil. By means of a phase-sensitive feedback scheme, we cool the harmonic motion of the nanoparticle from ambient to microkelvin temperatures and measure its reheating rate under the influence of the radiation field. The recoil heating rate is measured for different particle sizes and for different excitation powers, without the need for cavity optics or cryogenic environments. The measurements are in quantitative agreement with theoretical predictions and provide valuable guidance for the realization of quantum ground-state cooling protocols and the measurement of ultrasmall forces.

  1. Fabrication and testing of the recoil mass spectrometer at Bombay ...

    Indian Academy of Sciences (India)

    A recoil mass spectrometer (RMS) has been designed, fabricated and installed ... first order and only mass dispersion is obtained at the focal plane of the ... more details, like, the specifications and a typical beam profile through the ... Further experiments are now in progress to characterize the spectrometer, i.e., to measure.

  2. The Performance of the HRIBF Recoil Mass Spectrometry

    International Nuclear Information System (INIS)

    Ginter, T.N.

    1998-01-01

    The Recoil Mass Spectrometer (RMS) is a mass separator located at the Holifield Radioactive Ion Beam Facility (HRIBF) at Oak Ridge National Laboratory. This paper describes the RMS, its performance, its detector systems, and discusses some experiments to illustrate its capabilities

  3. Recoil range distribution measurement in 20Ne + 181Ta reaction

    International Nuclear Information System (INIS)

    Tripathi, R.; Sudarshan, K.; Goswami, A.; Guin, R.; Reddy, A.V.R.

    2005-01-01

    In order to investigate linear momentum transfer in various transfer channels in 20 Ne + 181 Ta, recoil range distribution measurements have been carried out at E lab = 180 MeV, populating significant number of l-waves above l crit

  4. Elastic recoil detection (ERD) with extremely heavy ions

    International Nuclear Information System (INIS)

    Forster, J.S.; Davies, J.A.; Siegele, R.; Wallace, S.G.; Zelenitsky, D.

    1996-01-01

    Extremely heavy-ion beams such as 209 Bi in elastic recoil detection (ERD) make ERD a uniquely valuable technique for thin-film analysis of elements with mass ≤100. We report ERD measurements of compositional analysis of dinosaur eggshells and bones. We also show the capability of the ERD technique on studies of thin-film, high-temperature superconductors. (orig.)

  5. Elevated prefrontal cortex γ-aminobutyric acid and glutamate-glutamine levels in schizophrenia measured in vivo with proton magnetic resonance spectroscopy.

    Science.gov (United States)

    Kegeles, Lawrence S; Mao, Xiangling; Stanford, Arielle D; Girgis, Ragy; Ojeil, Najate; Xu, Xiaoyan; Gil, Roberto; Slifstein, Mark; Abi-Dargham, Anissa; Lisanby, Sarah H; Shungu, Dikoma C

    2012-05-01

    Postmortem studies have found evidence of γ-aminobutyric acid (GABA) deficits in fast-spiking, parvalbumin-positive interneurons in the prefrontal cortex in schizophrenia. Magnetic resonance spectroscopy studies in unmedicated patients have reported glutamine or glutamate-glutamine (Glx) elevations in this region. Abnormalities in these transmitters are thought to play a role in cognitive impairments in the illness. To measure GABA and Glx levels in vivo in 2 prefrontal brain regions in unmedicated and medicated patients with schizophrenia and healthy controls. Case-control study. Inpatient psychiatric research unit and associated outpatient clinic. Sixteen unmedicated patients with schizophrenia, 16 medicated patients, and 22 healthy controls matched for age, sex, ethnicity, parental socioeconomic status, and cigarette smoking. Proton magnetic resonance spectroscopy with a 3-T system and the J-edited spin-echo difference method. The GABA and Glx levels were measured in the dorsolateral and medial prefrontal cortex and normalized to the simultaneously acquired water signal. Working memory performance was assessed in all subjects. The GABA and Glx concentrations determined by proton magnetic resonance spectroscopy. In the medial prefrontal cortex region, 30% elevations were found in GABA (P = .02) and Glx (P = .03) levels in unmedicated patients compared with controls. There were no alterations in the medicated patients or in either group in the dorsolateral prefrontal cortex. Both regions showed correlations between GABA and Glx levels in patients and controls. No correlations with working memory performance were found. To our knowledge, this study presents the first GABA concentration measurements in unmedicated patients with schizophrenia, who showed elevations in both GABA and Glx levels in the medial prefrontal cortex but not the dorsolateral prefrontal cortex. Medicated patients did not show these elevations, suggesting possible normalization of levels with

  6. Study of the interactions of 13.8 GeV/c protons with the heavy nuclei of the emulsions exposed in magnetic fuel of 170 kgauss; Estudio de las interacciones de protones de 13,8 geV/c con los nucleos pesados de emusiones

    Energy Technology Data Exchange (ETDEWEB)

    Gomez Aleixandre, J L

    1967-07-01

    145 stars with N{sub h}>8 produced by the interactions of 13.8 GeV/c protons with Ag and Br nuclei have been analysed. The emulsion stack was irradiated in a 170 K gauss magnetic field. Statistical results concerning the main characteristics of the different particles emitted are given and the energy balance is evaluated. The main features of both 24 GeV/c protons and 17 GeV/c {pi}- interactions are compared with those we have found for 13.8 GeV/c protons interactions. (Author) 27 refs.

  7. Repeatability of two-dimensional chemical shift imaging multivoxel proton magnetic resonance spectroscopy for measuring human cerebral choline-containing compounds.

    Science.gov (United States)

    Puri, Basant K; Egan, Mary; Wallis, Fintan; Jakeman, Philip

    2018-03-22

    To investigate the repeatability of proton magnetic resonance spectroscopy in the in vivo measurement of human cerebral levels of choline-containing compounds (Cho). Two consecutive scans were carried out in six healthy resting subjects at a magnetic field strength of 1.5 T. On each occasion, neurospectroscopy data were collected from 64 voxels using the same 2D chemical shift imaging (CSI) sequence. The data were analyzed in the same way, using the same software, to obtain the values for each voxel of the ratio of Cho to creatine. The Wilcoxon related-samples signed-rank test, coefficient of variation (CV), repeatability coefficient (RC), and intraclass correlation coefficient (ICC) were used to assess the repeatability. The CV ranged from 2.75% to 33.99%, while the minimum RC was 5.68%. There was excellent reproducibility, as judged by significant ICC values, in 26 voxels. Just three voxels showed significant differences according to the Wilcoxon related-samples signed-rank test. It is therefore concluded that when CSI multivoxel proton neurospectroscopy is used to measure cerebral choline-containing compounds at 1.5 T, the reproducibility is highly acceptable.

  8. The Final Merger of Massive Black Holes: Recoils, Gravitational Waves, and Electromagnetic Signatures

    Science.gov (United States)

    Centrella, Joan M.

    2010-01-01

    The final merger of two massive black holes produces a powerful burst of gravitational radiation, emitting more energy than all the stars in the observable universe combined. The resulting gravitational waveforms will be easily detectable by the space-based LISA out to redshifts z greater than 10, revealing the masses and spins of the black holes to high precision. If the merging black holes have unequal masses, or asymmetric spins, the final black hole that forms can recoil with a velocity exceeding 1000 km/s. And, when the black holes merge in the presence of gas and magnetic fields, various types of electromagnetic signals may also be produced. For more than 30 years, scientists have tried to compute black hole mergers using the methods of numerical relativity. The resulting computer codes have been plagued by instabilities, causing them to crash well before the black holes in the binary could complete even a single orbit. Within the past few years, however, this situation has changed dramatically, with a series of remarkable breakthroughs. This talk will focus on new results that are revealing the dynamics and waveforms of binary black hole mergers, recoil velocities, and the possibility of accompanying electromagnetic outbursts.

  9. Dynamical effects in proton breakup from exotic nuclei

    International Nuclear Information System (INIS)

    Bonaccorso, Angela; Kumar, Ravinder

    2012-01-01

    This contribution discusses dynamical effects in proton breakup from a weakly bound state in an exotic nucleus on a heavy target. The Coulomb interactions between the proton and the core and the proton and the target are treated to all orders, including also the full multipole expansion of the Coulomb potential. The dynamics of proton Coulomb breakup is compared to that of an equivalent neutron of larger binding energy in order to elucidate the differences with the well understood neutron breakup mechanism. A number of experimentally measurable observables such as parallel momentum distributions, proton angular distributions and total breakup cross sections can be calculated. With respect to nuclear breakup it is found that a proton behaves exactly as a neutron of larger binding energy. The extra “effective energy” is due to the combined core-target Coulomb barrier. In Coulomb breakup we distinguish the effect of the core-target Coulomb potential (called recoil effect), with respect to which the proton behaves again as a more bound neutron, from the direct proton-target Coulomb potential. The latter gives cross sections about an order of magnitude larger than the recoil term. The two effects give rise to complicated interferences in the parallel momentum distributions. They are instead easily separable in the proton angular distributions which are therefore suggested as a very useful observable for future experimental studies.

  10. ZGS beam transport for transverse or longitudinally polarized protons

    International Nuclear Information System (INIS)

    Colton, E.; Auer, I.P.; Beretvas, A.

    1977-01-01

    A combination of dipole magnets and a superconducting solenoid is utilized to transform the spin direction of transversely polarized protons from the Argonne ZGS for use in proton-proton scattering experiments

  11. Quantitative proton magnetic resonance spectroscopy of the normal liver and malignant hepatic lesions at 3.0 Tesla

    International Nuclear Information System (INIS)

    Fischbach, F.; Thormann, M.; Ricke, J.; Schirmer, T.; Freund, T.; Bruhn, H.

    2008-01-01

    This comparative study of tumour patients and volunteers aimed at differentiating liver parenchyma from neoplastic lesions by using localised 1 H MRS at 3.0 T as an adjunct to MRI. In total 186 single-voxel proton spectra of the liver were acquired at 3.0 T using the body transmit receive coil. Consecutive stacks of breath-hold spectra were acquired in the PRESS technique at a short echo time of 35 ms and a repetition time of 2,000 ms. Processing of the spectra included spectral alignment with the software package SAGE and quantitative processing with LCModel. The resulting metabolite concentrations were presented in arbitrary units relative to the internal water. In general, the spectra showed four main groups of resonances originating from the methyl protons (0.8-1.1 ppm) and methylene protons of the lipids (1.1-1.5 ppm; 2.0-2.2 ppm) as well as the methyl protons of choline-containing compounds (CCC) at 3.2 ppm. Overall, the CCC and lipid values in malignant liver tumours showed no significant differences to liver parenchyma. On average, total lipid measurements in normal liver parenchyma increased with age, while those of the CCC did not show pertinent changes. Significant differences between the contents of CCC in malignant liver tumours and normal liver parenchyma were not observed, because in patients and volunteers normal liver tissue showed a large variability in the content of CCC. (orig.)

  12. Hard two-photon contribution to elastic lepton-proton scattering determined by the OLYMPUS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, B.S. [Massachusetts Institute of Technology, Cambridge, MA (United States); Ice, L.D. [Arizona State Univ., Tempe, AZ (United States); Khaneft, D. [Mainz Univ. (Germany); Collaboration: OLYMPUS Collaboration; and others

    2016-12-15

    The OLYMPUS collaboration reports on a precision measurement of the positron-proton to electron-proton elastic cross section ratio, R{sub 2γ}, a direct measure of the contribution of hard two- photon exchange to the elastic cross section. In the OLYMPUS measurement, 2.01 GeV electron and positron beams were directed through a hydrogen gas target internal to the DORIS storage ring at DESY. A toroidal magnetic spectrometer instrumented with drift chambers and time-of-flight scintillators detected elastically scattered leptons in coincidence with recoiling protons over a scattering angle range of ∼20 to 80 . The relative luminosity between the two beam species was monitored using tracking telescopes of interleaved GEM and MWPC detectors at 12 , as well as symmetric Moeller/Bhabha calorimeters at 1.29 . A total integrated luminosity of 4.5 fb{sup -1} was collected. In the extraction of R{sub 2γ}, radiative effects were taken into account using a Monte Carlo generator to simulate the convolutions of internal bremsstrahlung with experiment-specific conditions such as detector acceptance and reconstruction efficiency. The resulting values of R{sub 2γ}, presented here for a wide range of virtual photon polarization 0.456<ε<0.978, are smaller than some hadronic two-photon exchange calculations predict, but are in reasonable agreement with a subtracted dispersion model and a phenomenological fit to the form factor data.

  13. Hard Two-Photon Contribution to Elastic Lepton-Proton Scattering Determined by the OLYMPUS Experiment

    Science.gov (United States)

    Henderson, B. S.; Ice, L. D.; Khaneft, D.; O'Connor, C.; Russell, R.; Schmidt, A.; Bernauer, J. C.; Kohl, M.; Akopov, N.; Alarcon, R.; Ates, O.; Avetisyan, A.; Beck, R.; Belostotski, S.; Bessuille, J.; Brinker, F.; Calarco, J. R.; Carassiti, V.; Cisbani, E.; Ciullo, G.; Contalbrigo, M.; de Leo, R.; Diefenbach, J.; Donnelly, T. W.; Dow, K.; Elbakian, G.; Eversheim, P. D.; Frullani, S.; Funke, Ch.; Gavrilov, G.; Gläser, B.; Görrissen, N.; Hasell, D. K.; Hauschildt, J.; Hoffmeister, Ph.; Holler, Y.; Ihloff, E.; Izotov, A.; Kaiser, R.; Karyan, G.; Kelsey, J.; Kiselev, A.; Klassen, P.; Krivshich, A.; Lehmann, I.; Lenisa, P.; Lenz, D.; Lumsden, S.; Ma, Y.; Maas, F.; Marukyan, H.; Miklukho, O.; Milner, R. G.; Movsisyan, A.; Murray, M.; Naryshkin, Y.; Perez Benito, R.; Perrino, R.; Redwine, R. P.; Rodríguez Piñeiro, D.; Rosner, G.; Schneekloth, U.; Seitz, B.; Statera, M.; Thiel, A.; Vardanyan, H.; Veretennikov, D.; Vidal, C.; Winnebeck, A.; Yeganov, V.; Olympus Collaboration

    2017-03-01

    The OLYMPUS Collaboration reports on a precision measurement of the positron-proton to electron-proton elastic cross section ratio, R2 γ , a direct measure of the contribution of hard two-photon exchange to the elastic cross section. In the OLYMPUS measurement, 2.01 GeV electron and positron beams were directed through a hydrogen gas target internal to the DORIS storage ring at DESY. A toroidal magnetic spectrometer instrumented with drift chambers and time-of-flight scintillators detected elastically scattered leptons in coincidence with recoiling protons over a scattering angle range of ≈20 ° to 80°. The relative luminosity between the two beam species was monitored using tracking telescopes of interleaved gas electron multiplier and multiwire proportional chamber detectors at 12°, as well as symmetric Møller or Bhabha calorimeters at 1.29°. A total integrated luminosity of 4.5 fb-1 was collected. In the extraction of R2 γ, radiative effects were taken into account using a Monte Carlo generator to simulate the convolutions of internal bremsstrahlung with experiment-specific conditions such as detector acceptance and reconstruction efficiency. The resulting values of R2 γ, presented here for a wide range of virtual photon polarization 0.456 <ɛ <0.978 , are smaller than some hadronic two-photon exchange calculations predict, but are in reasonable agreement with a subtracted dispersion model and a phenomenological fit to the form factor data.

  14. A recoil resilient lumen support, design, fabrication and mechanical evaluation

    Science.gov (United States)

    Mehdizadeh, Arash; Ali, Mohamed Sultan Mohamed; Takahata, Kenichi; Al-Sarawi, Said; Abbott, Derek

    2013-06-01

    Stents are artificial implants that provide scaffolding to a cavity inside the body. This paper presents a new luminal device for reducing the mechanical failure of stents due to recoil, which is one of the most important issues in stenting. This device, which we call a recoil-resilient ring (RRR), is utilized standalone or potentially integrated with existing stents to address the problem of recoil. The proposed structure aims to minimize the need for high-pressure overexpansion that can induce intra-luminal trauma and excess growth of vascular tissue causing later restenosis. The RRR is an overlapped open ring with asymmetrical sawtooth structures that are intermeshed. These teeth can slide on top of each other, while the ring is radially expanded, but interlock step-by-step so as to keep the final expanded state against compressional forces that normally cause recoil. The RRRs thus deliver balloon expandability and, when integrated with a stent, bring both radial rigidity and longitudinal flexibility to the stent. The design of the RRR is investigated through finite element analysis (FEA), and then the devices are fabricated using micro-electro-discharge machining of 200-µm-thick Nitinol sheet. The standalone RRR is balloon expandable in vitro by 5-7 Atm in pressure, which is well within the recommended in vivo pressure ranges for stenting procedures. FEA compression tests indicate 13× less reduction of the cross-sectional area of the RRR compared with a typical stainless steel stent. These results also show perfect elastic recovery of the RRR after removal of the pressure compared to the remaining plastic deformations of the stainless steel stent. On the other hand, experimental loading tests show that the fabricated RRRs have 2.8× radial stiffness compared to a two-column section of a commercial stent while exhibiting comparable elastic recovery. Furthermore, testing of in vitro expansion in a mock artery tube shows around 2.9% recoil, approximately 5-11

  15. A recoil resilient lumen support, design, fabrication and mechanical evaluation

    International Nuclear Information System (INIS)

    Mehdizadeh, Arash; Al-Sarawi, Said; Abbott, Derek; Ali, Mohamed Sultan Mohamed; Takahata, Kenichi

    2013-01-01

    Stents are artificial implants that provide scaffolding to a cavity inside the body. This paper presents a new luminal device for reducing the mechanical failure of stents due to recoil, which is one of the most important issues in stenting. This device, which we call a recoil-resilient ring (RRR), is utilized standalone or potentially integrated with existing stents to address the problem of recoil. The proposed structure aims to minimize the need for high-pressure overexpansion that can induce intra-luminal trauma and excess growth of vascular tissue causing later restenosis. The RRR is an overlapped open ring with asymmetrical sawtooth structures that are intermeshed. These teeth can slide on top of each other, while the ring is radially expanded, but interlock step-by-step so as to keep the final expanded state against compressional forces that normally cause recoil. The RRRs thus deliver balloon expandability and, when integrated with a stent, bring both radial rigidity and longitudinal flexibility to the stent. The design of the RRR is investigated through finite element analysis (FEA), and then the devices are fabricated using micro-electro-discharge machining of 200-µm-thick Nitinol sheet. The standalone RRR is balloon expandable in vitro by 5–7 Atm in pressure, which is well within the recommended in vivo pressure ranges for stenting procedures. FEA compression tests indicate 13× less reduction of the cross-sectional area of the RRR compared with a typical stainless steel stent. These results also show perfect elastic recovery of the RRR after removal of the pressure compared to the remaining plastic deformations of the stainless steel stent. On the other hand, experimental loading tests show that the fabricated RRRs have 2.8× radial stiffness compared to a two-column section of a commercial stent while exhibiting comparable elastic recovery. Furthermore, testing of in vitro expansion in a mock artery tube shows around 2.9% recoil, approximately 5

  16. Measurement of proton momentum distributions using a direct geometry instrument

    International Nuclear Information System (INIS)

    Senesi, R; Andreani, C; Kolesnikov, A I

    2014-01-01

    We report the results of inelastic neutron scattering measurements on bulk water and ice using the direct geometry SEQUOIA chopper spectrometer at the Spallation Neutron Source (USA), with incident energy E i = 6 eV. In this set up the measurements allow to access the Deep Inelastic Neutron Scattering regime. The scattering is centred at the proton recoil energy given by the impulse approximation, and the shape of the recoil peak conveys information on the proton momentum distribution in the system. The comparison with the performance of inverse geometry instruments, such as VESUVIO at the ISIS source (UK), shows that complementary information can be accessed by the use of direct and inverse geometry instruments. Analysis of the neutron Compton profiles shows that the proton kinetic energy in ice at 271 K is larger than in room temperature liquid water, in agreement with previous measurements on VESUVIO

  17. Proton storage rings

    International Nuclear Information System (INIS)

    Rau, R.R.

    1978-04-01

    A discussion is given of proton storage ring beam dynamic characteristics. Topics considered include: (1) beam energy; (2) beam luminosity; (3) limits on beam current; (4) beam site; (5) crossing angle; (6) beam--beam interaction; (7) longitudinal instability; (8) effects of scattering processes; (9) beam production; and (10) high magnetic fields. Much of the discussion is related to the design parameters of ISABELLE, a 400 x 400 GeV proton---proton intersecting storage accelerator to be built at Brookhaven National Laboratory

  18. Recoil properties of radionuclides formed in photospallation reactions on complex nuclei at intermediate energies

    International Nuclear Information System (INIS)

    Haba, Hiromitsu; Oura, Yasuji; Shibata, Seiichi; Furukawa, Michiaki; Fujiwara, Ichiro

    2001-01-01

    A short review is given on our studies of recoil properties of radionuclides formed in photospallation reactions induced by bremsstrahlung of end-point energies (E 0 ) from 600 to 1100 MeV, in which the thick-target thick-catcher method was employed. The measurements have been successful on 14, 24, 26, 31, 21 and 20 nuclides from nat V, nat Cu, 93 Nb, nat Ag, nat Ta, and 197 Au, respectively. Reflecting the resonance character in a photonuclear reaction, the mean ranges FW and BW in the forward and backward directions, respectively, are E 0 -independent at the studied energies and classified into two groups accounting for the (γ, xn) (x ≥ 1) and (γ, xnyp) (x, y ≥ 1) processes. The forward-to-backward ratios (F/B) are independent of the mass difference (ΔA) between a product (A p ) and a target (A t ) and also of A t . The kinematic properties of the product nuclei were analyzed by the two-step vector velocity model. The forward velocity ν after the first step of photon-reaction is quite different from that of proton-reaction at proton energies of E p ≤ 3 GeV, though the difference disappears at higher energies. On the other hand, the mean kinetic energy T of the residual nucleus in the second step is almost equal to that of proton-reaction irrespective of E p . A comparison with T values calculated by the PICA (Photon-Induced Intranuclear Cascade Analysis) code at E 0 =400 MeV was also performed. It was found that although the code well reproduces the experimental results of nat V and nat Cu, the same calculation for heavier targets gives T values lower than the experimental results, indicating some nuclear-structure effect, such as a medium effect notably at A t ≥ 100. An average kinetic energy carried off by the emitted particles ε s =T/(ΔA/A t ) of both photon- and proton-reactions seem to increase with an increase of A t up to around A t =100, and become almost constant at larger A t , implying some change in the nuclear structure effect in this

  19. Preliminary results of proton ring current observations in time of magnetic perturbations with the 'Molniya-1' satellite

    International Nuclear Information System (INIS)

    Grechin, A.N.; Kovrygina, L.M.; Kovtyukh, A.S.

    1975-01-01

    The experimental results of observation on the injection of the annular current protons (30< Esub(r)<380 KeV) into the radiation band during the storm on October 28, 1973 and three storms on January 1, 1974, July 12 and 21, 1974, with the maximum values of Dsup(st) of 65, 30, and 20γ, respectively, are described. During the main phases of the storms the assymetry of the annular current of protons relative to the mid-day-mid-night meridian was observed. The injection of the particles was being accompanied by variation of the shape of the spectrum on the internal edge of the annular current. The possible effect of the ion-cyclotron instability on the formation of the initial edge of the annular current has been analyzed. Immediately after the main phases of the storms on July 12 and 21, 1974, a gap in the spectum within the pre-mid-night sector, with the energies amounting to several dozens of KeV was observed. The formation of this gap may be explained by the development of the instability which results in the pinch-angular diffusion of protons and their decay in the region of plasmapause

  20. Proton nuclear magnetic resonance study of the ferrous derivatives of the dimeric and tetrameric hemoglobin from the mollusc Scapharca inaequivalvis

    International Nuclear Information System (INIS)

    Inubushi, Toshiero; Yonetani, Takahashi; Chiancone, E.; Univ. 'La Sapienza', Rome

    1988-01-01

    Proton NMR spectra have been measured for the two hemoglobins from the mollusc Scapharca inaequivalvis: HbI, a homodimer, and HbII, a heterotetramer. These hemoglobins are endowed with a unique subunit assembly, since the heme carrying E and F helices are involved in the major intersubunit contact. In the far-downfield region of hyperfine-shifted resonances the spectra of HbI and HbII in the deoxy state show respectively one (66.7 ppm) and two (67.8 and 63.6 ppm) exchangeable signals of the proximal histidine N/sub delta/H groups, the resonance position being indicative of a significant strain in the iron-imidazole interaction. In the hydrogen-bonded proton region, inter-and intrasubunit hydrogen-bonded proton signals have been detected for both hemoglobins. Deoxy-HbI shows two unique downfied resonances at 11.83 and 11.51 ppm which disappear in the oxygenated state, suggesting that the corresponding hydrogen bonds are iinvolved in the stabilization of the tertiary and/or quaternary structure of the deoxy form. HbII shows even smaller changes in this region upon changes in ligation state. These results therefore provide further proof that, at variance with the vertebrate hemoglobin tetramer, the unique subunit assembly of these proteins is stabilized mainly by hydrophobic interactions

  1. Elastic recoil detection analysis of hydrogen in polymers

    Energy Technology Data Exchange (ETDEWEB)

    Winzell, T R.H.; Whitlow, H J [Lund Univ. (Sweden); Bubb, I F; Short, R; Johnston, P N [Royal Melbourne Inst. of Tech., VIC (Australia)

    1997-12-31

    Elastic recoil detection analysis (ERDA) of hydrogen in thick polymeric films has been performed using 2.5 MeV He{sup 2+} ions from the tandem accelerator at the Royal Melbourne Institute of Technology. The technique enables the use of the same equipment as in Rutherford backscattering analysis, but instead of detecting the incident backscattered ion, the lighter recoiled ion is detected at a small forward angle. The purpose of this work is to investigate how selected polymers react when irradiated by helium ions. The polymers are to be evaluated for their suitability as reference standards for hydrogen depth profiling. Films investigated were Du Pont`s Kapton and Mylar, and polystyrene. 11 refs., 3 figs.

  2. Elastic recoil detection analysis of hydrogen in polymers

    Energy Technology Data Exchange (ETDEWEB)

    Winzell, T.R.H.; Whitlow, H.J. [Lund Univ. (Sweden); Bubb, I.F.; Short, R.; Johnston, P.N. [Royal Melbourne Inst. of Tech., VIC (Australia)

    1996-12-31

    Elastic recoil detection analysis (ERDA) of hydrogen in thick polymeric films has been performed using 2.5 MeV He{sup 2+} ions from the tandem accelerator at the Royal Melbourne Institute of Technology. The technique enables the use of the same equipment as in Rutherford backscattering analysis, but instead of detecting the incident backscattered ion, the lighter recoiled ion is detected at a small forward angle. The purpose of this work is to investigate how selected polymers react when irradiated by helium ions. The polymers are to be evaluated for their suitability as reference standards for hydrogen depth profiling. Films investigated were Du Pont`s Kapton and Mylar, and polystyrene. 11 refs., 3 figs.

  3. Recoil distance lifetime measurements in 122,124Xe

    Science.gov (United States)

    Govil, I. M.; Kumar, A.; Iyer, H.; Li, H.; Garg, U.; Ghugre, S. S.; Johnson, T.; Kaczarowski, R.; Kharraja, B.; Naguleswaran, S.; Walpe, J. C.

    1998-02-01

    Lifetimes of the lower-excited states in 122,124Xe are measured using the recoil-distance Doppler-shift technique. The reactions 110Pd(16O,4n)122Xe and 110Pd(18O,4n)124Xe at a beam energy of 66 MeV were used for this experiment. The lifetimes of the 2+, 4+, 6+, and 8+ states of the ground state band were extracted using the computer code LIFETIME including the corrections due to the side feeding and the nuclear deorientation effects. The lifetime of the 2+ state in 122Xe agrees with the recoil distance method (RDM) measurements but for the 124Xe it does not agree with the RDM measurements but agrees with the Coulomb-excitation experiment. The measured B(E2) values for both the nuclei are compared with the standard algebraic and the multishell models.

  4. Superheated superconducting granule detector tested with nuclear recoil measurements

    International Nuclear Information System (INIS)

    Berger, C.; Czapek, G.; Diggelmann, U.; Flammer, I.; Frei, D.; Furlan, M.; Gabutti, A.; Janos, S.; Moser, U.; Pretzl, K.; Schmiemann, K.; Perret-Gallix, D.; Brandt, B. van den; Konter, J.A.; Mango, S.

    1993-01-01

    The presented results are part of a superheated superconducting granule (SSG) detector development for neutrino and dark matter. The aim of the experiment was to measure the sensitivity of the detector to nuclear recoil energies when exposed to a 70 MeV neutron beam. The detector consists of a small readout coil (diameter 5 mm, length 10 mm) filled with aluminum granules of average diameter 23 μm embedded in an Al 2 O 3 granulate with a 6% volume filling factor. The neutron scattering angles were determined using a scintillator hodoscope. Coincidences between the SSG and the hodoscope signals have been clearly established. Data were taken at an operating temperature of 120 mK for different SSG intrinsic thresholds. The results prove the sensitivity of the detector to nuclear recoils around 10 keV. (orig.)

  5. Dynamical Formation of Horizons in Recoiling D Branes

    CERN Document Server

    Ellis, Jonathan Richard; Nanopoulos, Dimitri V; Ellis, John

    2000-01-01

    A toy calculation of string/D-particle interactions within a world-sheet approach indicates that quantum recoil effects - reflecting the gravitational back-reaction on space-time foam due to the propagation of energetic particles - induces the appearance of a microscopic event horizon, or `bubble', inside which stable matter can exist. The scattering event causes this horizon to expand, but we expect quantum effects to cause it to contract again, in a `bounce' solution. Within such `bubbles', massless matter propagates with an effective velocity that is less than the velocity of light in vacuo, which may lead to observable violations of Lorentz symmetry that may be tested experimentally. The conformal invariance conditions in the interior geometry of the bubbles select preferentially three for the number of the spatial dimensions, corresponding to a consistent formulation of the interaction of D3 branes with recoiling D particles, which are allowed to fluctuate independently only on the D3-brane hypersurface.

  6. The fuzzy bag and baryonic properties with center of mass and recoil corrections

    International Nuclear Information System (INIS)

    Pilotto, F.

    2003-01-01

    The fuzzy bag is a hadronic model which has features both of the bag model (energy-momentum conservation, QCD vacuum energy) and of relativistic potential models (confinement achieved through a potential). It is also a chiral model, with the unique property that the pion field is suppressed in the interior of the bag by means of a scalar potential, and yet chiral symmetry is preserved. This scalar potential allows one to control how far the pion field can penetrate in the interior of the bag. We calculate the masses of the fundamental baryon octet taking into account the center of mass, one-gluon exchange and one-pion exchange corrections. We also calculate the nucleon axial charge, charge radii and magnetic moments including center of mass and recoil corrections. The agreement with experiment is excellent, and the results indicate that the pion field is suppressed only very close to the center of the bag. (orig.)

  7. High energy neutron recoil scattering from liquid 4He

    International Nuclear Information System (INIS)

    Holt, R.S.; Needham, L.M.; Paoli, M.P.

    1987-10-01

    The neutron recoil scattering from liquid 4 He at 4.2 K and 1.6 K has been observed for a momentum transfer of 150 A -1 using the Electron Volt Spectrometer on the pulsed neutron source, ISIS. The experiment yielded mean atomic kinetic energy values = 14.8 +- 3 K at 4.2 K and = 14.6 +- 3.2 K at 1.6 K in good agreement with values obtained at lower momentum transfers. (author)

  8. Recoil corrected bag model calculations for semileptonic weak decays

    International Nuclear Information System (INIS)

    Lie-Svendsen, Oe.; Hoegaasen, H.

    1987-02-01

    Recoil corrections to various model results for strangeness changing weak decay amplitudes have been developed. It is shown that the spurious reference frame dependence of earlier calculations is reduced. The second class currents are generally less important than obtained by calculations in the static approximation. Theoretical results are compared to observations. The agreement is quite good, although the values for the Cabibbo angle obtained by fits to the decay rates are somewhat to large

  9. Penetration of HEPA filters by alpha recoil aerosols

    International Nuclear Information System (INIS)

    McDowell, W.J.; Seeley, F.G.; Ryan, M.T.

    1976-01-01

    The self-scattering of alpha-active substances has long been recognized and is attributed to expulsion of aggregates of atoms from the surface of alpha-active materials by alpha emission recoil energy, and perhaps to further propulsion of these aggregates by subsequent alpha recoils. Workers at the University of Lowell recently predicted that this phenomenon might affect the retention of alpha-active particulate matter by HEPA filters, and found support in experiments with 212 Pb. Tests at Oak Ridge National Laboratory have confirmed that alpha-emitting particulate matter does penetrate high-efficiency filter media, such as that used in HEPA filters, much more effectively than do non-radioactive or beta-gamma active aerosols. Filter retention efficiencies drastically lower than the 99.9 percent quoted for ordinary particulate matter were observed with 212 Pb, 253 Es, and 238 Pu sources, indicating that the phenomenon is common to all of these and probably to all alpha-emitting materials of appropriate half-life. Results with controlled air-flow through filters in series are consistent with the picture of small particles dislodged from the ''massive'' surface of an alpha-active material, and then repeatedly dislodged from positions on the filter fibers by subsequent alpha recoils. The process shows only a small dependence on the physical form of the source material. Oxide dust, nitrate salt, and plated metal all seem to generate the recoil particles effectively. The amount penetrating a series of filters depends on the total amount of activity in the source material, its specific activity, and the length of time of air flow

  10. New developments of the recoil distance doppler-shift method

    Energy Technology Data Exchange (ETDEWEB)

    Fransen, Christoph; Blazhev, Andrey; Braunroth, Thomas; Dewald, Alfred; Goldkuhle, Alina; Jolie, Jan; Litzinger, Julia; Mueller-Gatermann, Claus; Woelk, Dorothea; Zell, Karl-Oskar [Institut fuer Kernphysik, Universitaet zu Koeln (Germany)

    2016-07-01

    The recoil distance Doppler-shift (RDDS) method is a very valuable technique for measuring lifetimes of excited nuclear states in the picosecond range to deduce absolute transition strengths between nuclear excitations independent on the reaction mechanism. Dedicated plunger devices were built by our group for measurements with this method for a broad range of beam energies ranging from few MeV/u up to relativistic energies of the order of 100 MeV/u. Those were designed to match the constraints defined by state-of-the art γ-ray spectrometers like AGATA, Galileo, Gammasphere. Here we give an overview about recent experiments of our group to determine transition strengths from level lifetimes in exotic nuclei where also recoil separators or mass spectrographs were used for an identification of the recoiling reaction products. The aim is to learn about phenomena like shape phase coexistence in exotic regions and the evolution of the shell structure far from the valley of stability. We also review new plunger devices that are developed by our group for future experimental campaigns with stable and radioactive beams in different energy regimes, e.g., a plunger for HIE-ISOLDE.

  11. D-particle Recoil Space Times and "Glueball" Masses

    CERN Document Server

    Mavromatos, Nikolaos E; Mavromatos, Nick E.; Winstanley, Elizabeth

    2001-01-01

    We discuss the properties of matter in a D-dimensional anti-de-Sitter-type space time induced dynamically by the recoil of a very heavy D(irichlet)-particle defect embedded in it. The particular form of the recoil geometry, which from a world-sheet view point follows from logarithmic conformal field theory deformations of the pertinent sigma-models, results in the presence of both infrared and ultraviolet (spatial) cut-offs. These are crucial in ensuring the presence of mass gaps in scalar matter propagating in the D-particle recoil space time. The analogy of this problem with the Liouville-string approach to QCD, suggested earlier by John Ellis and one of the present authors, prompts us to identify the resulting scalar masses with those obtained in the supergravity approach based on the Maldacena's conjecture, but without the imposition of any supersymmetry in our case. Within reasonable numerical uncertainties, we observe that agreement is obtained between the two approaches for a particular value of the ra...

  12. Recoiling Black Holes: Electromagnetic Signatures, Candidates, and Astrophysical Implications

    Directory of Open Access Journals (Sweden)

    S. Komossa

    2012-01-01

    Full Text Available Supermassive black holes (SMBHs may not always reside right at the centers of their host galaxies. This is a prediction of numerical relativity simulations, which imply that the newly formed single SMBH, after binary coalescence in a galaxy merger, can receive kick velocities up to several 1000 km/s due to anisotropic emission of gravitational waves. Long-lived oscillations of the SMBHs in galaxy cores, and in rare cases even SMBH ejections from their host galaxies, are the consequence. Observationally, accreting recoiling SMBHs would appear as quasars spatially and/or kinematically offset from their host galaxies. The presence of the “kicks” has a wide range of astrophysical implications which only now are beginning to be explored, including consequences for black hole and galaxy assembly at the epoch of structure formation, black hole feeding, and unified models of active galactic nuclei (AGN. Here, we review the observational signatures of recoiling SMBHs and the properties of the first candidates which have emerged, including follow-up studies of the candidate recoiling SMBH of SDSSJ092712.65+294344.0.

  13. A new recoil filter for {gamma}-detector arrays

    Energy Technology Data Exchange (ETDEWEB)

    Heese, J; Lahmer, W; Maier, K H [Hahn-Meitner-Institut Berlin GmbH (Germany); Janicki, M; Meczynski, W; Styczen, J [Institute of Nuclear Physics, Cracow (Poland)

    1992-08-01

    A considerable improvement of gamma spectra recorded in heavy ion induced fusion evaporation residues can be achieved when gamma rays are detected in coincidence with the recoiling evaporations residues. This coincidence suppresses gamma rays from fission processes, Coulombic excitation, and reactions with target contaminations, and therefore cleans gamma spectra and improves the peak to background ratio. A sturdy detector for evaporation residues has been designed as an additional detector for the OSIRIS spectrometer. The recoil filter consists of two rings of six and twelve detector elements. In each detector element, nuclei hitting a thin Mylar foil produce secondary electrons, which are electrostatically accelerated and focussed onto a thin plastic scintillator. Recoiling evaporation residues are discriminated from other reaction products and scattered beam by the pulse height of the scintillation signal and time of flight. The detector signal is fast enough to allow the detection of an evaporation residue even if the scattered beam hits the detector first. In-beam experiment were performed with the reactions {sup 40}Ar+{sup 124}Sn, {sup 40}Ar+{sup 152}Sm at 185 MeV beam energy, and {sup 36}Ar+{sup 154,156}Gd at 175 MeV. In the latter two cases, fission amount to 50-75% of the total fusion cross section. 10 refs., 4 figs.

  14. Investigation of the structure of isobutylene oligomers, used in the capacity of stock for succinimide additives, by the method of proton magnetic resonance

    Energy Technology Data Exchange (ETDEWEB)

    Iarmoliuk, V.M.; Garun, Ia.E.; Ostroverkhov, V.G.; Pustovit, V.E.; Tikhonov, V.P.

    1980-01-01

    By the method of proton magnetic resonance, investigation was made of the structure of hydrocarbon framework of isobutylene oligomers of the Salavatsk petrochemical plant, produced by the cation polymerization of the isobutane isobutylene fraction at a temperature from -10 to +20/sup 0/ with A1C1/sub 3/ and used in the production of succinide additives. Determination was made of the qualitative and quantitative compositions of the various structures in the oligomers. It is shown, that as a rule, oligobutenes are not pure oligomers of isobutylene, but represent, at least, fragments of four structures, which can be formed on the basis of isobutylene. The content of the given structures does not affect the reaction capacity of the oligomers in respect to the maleic anhydride. It was established, that the low molecular fraction, contained in oligomers up to 5%, are not isobutylene oligomers, but represent a low molecular polymer of butene-2 and its copolymer with isobutylene.

  15. In-Vivo Proton Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate in Isocitrate Dehydrogenase-Mutated Gliomas: A Technical Review for Neuroradiologists

    International Nuclear Information System (INIS)

    Kim, Hyeonjin; Kim, Sungjin; Lee, Hyeong Hun; Heo, Hwon

    2016-01-01

    The diagnostic and prognostic potential of an onco-metabolite, 2-hydroxyglutarate (2HG) as a proton magnetic resonance spectroscopy (1H-MRS) detectable biomarker of the isocitrate dehydrogenase (IDH)-mutated (IDH-MT) gliomas has drawn attention of neuroradiologists recently. However, due to severe spectral overlap with background signals, quantification of 2HG can be very challenging. In this technical review for neuroradiologists, first, the biochemistry of 2HG and its significance in the diagnosis of IDH-MT gliomas are summarized. Secondly, various 1H-MRS methods used in the previous studies are outlined. Finally, wereview previous in vivo studies, and discuss the current status of 1H-MRS in the diagnosis of IDH-MT gliomas

  16. In-Vivo Proton Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate in Isocitrate Dehydrogenase-Mutated Gliomas: A Technical Review for Neuroradiologists

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyeonjin [Department of Radiology, Seoul National University Hospital, Seoul 03080 (Korea, Republic of); Department of Biomedical Sciences, Seoul National University, Seoul 03087 (Korea, Republic of); Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul 03080 (Korea, Republic of); Kim, Sungjin [Department of Radiology, Seoul National University Hospital, Seoul 03080 (Korea, Republic of); Lee, Hyeong Hun; Heo, Hwon [Department of Biomedical Sciences, Seoul National University, Seoul 03087 (Korea, Republic of)

    2016-11-01

    The diagnostic and prognostic potential of an onco-metabolite, 2-hydroxyglutarate (2HG) as a proton magnetic resonance spectroscopy (1H-MRS) detectable biomarker of the isocitrate dehydrogenase (IDH)-mutated (IDH-MT) gliomas has drawn attention of neuroradiologists recently. However, due to severe spectral overlap with background signals, quantification of 2HG can be very challenging. In this technical review for neuroradiologists, first, the biochemistry of 2HG and its significance in the diagnosis of IDH-MT gliomas are summarized. Secondly, various 1H-MRS methods used in the previous studies are outlined. Finally, wereview previous in vivo studies, and discuss the current status of 1H-MRS in the diagnosis of IDH-MT gliomas.

  17. Signal yields of keV electronic recoils and their discrimination from nuclear recoils in liquid xenon

    Science.gov (United States)

    Aprile, E.; Aalbers, J.; Agostini, F.; Alfonsi, M.; Amaro, F. D.; Anthony, M.; Arneodo, F.; Barrow, P.; Baudis, L.; Bauermeister, B.; Benabderrahmane, M. L.; Berger, T.; Breur, P. A.; Brown, A.; Brown, E.; Bruenner, S.; Bruno, G.; Budnik, R.; Bütikofer, L.; Calvén, J.; Cardoso, J. M. R.; Cervantes, M.; Cichon, D.; Coderre, D.; Colijn, A. P.; Conrad, J.; Cussonneau, J. P.; Decowski, M. P.; de Perio, P.; di Gangi, P.; di Giovanni, A.; Diglio, S.; Eurin, G.; Fei, J.; Ferella, A. D.; Fieguth, A.; Fulgione, W.; Gallo Rosso, A.; Galloway, M.; Gao, F.; Garbini, M.; Geis, C.; Goetzke, L. W.; Grandi, L.; Greene, Z.; Grignon, C.; Hasterok, C.; Hogenbirk, E.; Howlett, J.; Itay, R.; Kaminsky, B.; Kazama, S.; Kessler, G.; Kish, A.; Landsman, H.; Lang, R. F.; Lellouch, D.; Levinson, L.; Lin, Q.; Lindemann, S.; Lindner, M.; Lombardi, F.; Lopes, J. A. M.; Mahlstedt, J.; Manfredini, A.; Maris, I.; Marrodán Undagoitia, T.; Masbou, J.; Massoli, F. V.; Masson, D.; Mayani, D.; Messina, M.; Micheneau, K.; Molinario, A.; Morâ, K.; Murra, M.; Naganoma, J.; Ni, K.; Oberlack, U.; Pakarha, P.; Pelssers, B.; Persiani, R.; Piastra, F.; Pienaar, J.; Pizzella, V.; Piro, M.-C.; Plante, G.; Priel, N.; Ramírez García, D.; Rauch, L.; Reichard, S.; Reuter, C.; Rizzo, A.; Rupp, N.; Saldanha, R.; Dos Santos, J. M. F.; Sartorelli, G.; Scheibelhut, M.; Schindler, S.; Schreiner, J.; Schumann, M.; Scotto Lavina, L.; Selvi, M.; Shagin, P.; Shockley, E.; Silva, M.; Simgen, H.; Sivers, M. V.; Stein, A.; Thers, D.; Tiseni, A.; Trinchero, G.; Tunnell, C.; Vargas, M.; Wang, H.; Wang, Z.; Wei, Y.; Weinheimer, C.; Wittweg, C.; Wulf, J.; Ye, J.; Zhang, Y.; Zhu, T.; Xenon Collaboration

    2018-05-01

    We report on the response of liquid xenon to low energy electronic recoils below 15 keV from beta decays of tritium at drift fields of 92 V /cm , 154 V /cm and 366 V /cm using the XENON100 detector. A data-to-simulation fitting method based on Markov Chain Monte Carlo is used to extract the photon yields and recombination fluctuations from the experimental data. The photon yields measured at the two lower fields are in agreement with those from literature; additional measurements at a higher field of 366 V /cm are presented. The electronic and nuclear recoil discrimination as well as its dependence on the drift field and photon detection efficiency are investigated at these low energies. The results provide new measurements in the energy region of interest for dark matter searches using liquid xenon.

  18. Roles of the β 146 histidyl residue in the molecular basis of the Bohr Effect of hemoglobin: A proton nuclear magnetic resonance study

    International Nuclear Information System (INIS)

    Busch, M.R.; Mace, J.E.; Ho, N.T.; Ho, Chien

    1991-01-01

    Assessment of the roles of the carboxyl-terminal β146 histidyl residues in the alkaline Bohr effect in human and normal adult hemoglobin by high-resolution proton nuclear magnetic resonance spectroscopy requires assignment of the resonances corresponding to these residues. By a careful spectroscopic study of human normal adult hemoglobin, enzymatically prepared des(His146β)-hemoglobin, and the mutant hemoglobins Cowtown (β146His → Leu) and York (β146His → Pro), the authors have resolved some of these conflicting results. By a close incremental variation of pH over a wide range in chloride-free 0.1 M N-(2-hydroxyethyl)piperazine-N'-2-ethanesulfonic acid buffer, a single resonance has been found to be consistently missing in the proton nuclear magnetic resonance spectra of these hemoglobin variants. The results indicate that the contribution of the β146 histidyl residues is 0.52 H + /hemoglobin tetramer at pH 7.6, markedly less than 0.8 H + /hemoglobin tetramer estimated by study of the mutant hemoglobin Cowtown (β146His → Leu) by Shih and Perutz. They have found that at least two histidyl residues in the carbonmonoxy form of this mutant have pK values that are perturbed, and they suggest that these pK differences may in part account for this discrepancy. The results show that the pK values of β146 histidyl residues in the carbonmonoxy form of hemoglobin are substantially affected by the presence of chloride and other anions in the solvent, and thus, the contribution of this amino acid residue to the alkaline Bohr effect can be shown to vary widely in magnitude, depending on the solvent composition. These results demonstrate that the detailed molecular mechanisms of the alkaline Bohr effect are not unique but are affected both by the hemoglobin structure and by the interactions with the solvent components in which the hemoglobin molecule resides

  19. 7T Proton Magnetic Resonance Spectroscopy of Gamma-Aminobutyric Acid, Glutamate, and Glutamine Reveals Altered Concentrations in Patients With Schizophrenia and Healthy Siblings.

    Science.gov (United States)

    Thakkar, Katharine N; Rösler, Lara; Wijnen, Jannie P; Boer, Vincent O; Klomp, Dennis W J; Cahn, Wiepke; Kahn, René S; Neggers, Sebastiaan F W

    2017-03-15

    The N-methyl-D-aspartate receptor hypofunction model of schizophrenia predicts dysfunction in both glutamatergic and gamma-aminobutyric acidergic (GABAergic) transmission. We addressed this hypothesis by measuring GABA, glutamate, glutamine, and the sum of glutamine plus glutamate concentrations in vivo in patients with schizophrenia using proton magnetic resonance spectroscopy at 7T, which allows separation of metabolites that would otherwise overlap at lower field strengths. In addition, we investigated whether altered levels of GABA, glutamate, glutamine, and the sum of glutamine plus glutamate reflect genetic vulnerability to schizophrenia by including healthy first-degree relatives. Proton magnetic resonance spectroscopy at 7T was performed in 21 patients with chronic schizophrenia who were taking medication, 23 healthy first-degree relatives of patients with schizophrenia, and 24 healthy nonrelatives. Glutamate, glutamine, and GABA were measured cortically and subcortically in bilateral basal ganglia and occipital cortex. Patients with schizophrenia had reduced cortical GABA compared with healthy relatives and the combined sample of healthy relatives and healthy nonrelatives, suggesting that altered GABAergic systems in schizophrenia are associated with either disease state or medication effects. Reduced cortical glutamine relative to healthy control subjects was observed in patients with schizophrenia and the combined sample of healthy relatives and patients with schizophrenia, suggesting that altered glutamatergic metabolite levels are associated with illness liability. No group differences were found in the basal ganglia. Taken together, these findings are consistent with alterations in GABAergic and glutamatergic systems in patients with schizophrenia and provide novel insights into these systems in healthy relatives. Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

  20. Hydrogenated graphenes by birch reduction: influence of electron and proton sources on hydrogenation efficiency, magnetism, and electrochemistry

    Czech Academy of Sciences Publication Activity Database

    Eng, A.Y.S.; Sofer, Z.; Huber, Š.; Bouša, D.; Maryško, Miroslav; Pumera, M.

    2015-01-01

    Roč. 21, č. 7 (2015), 16828-16838 ISSN 0947-6539 Institutional support: RVO:68378271 Keywords : hydrogenated graphenes * birch reduction * magnetism * electrochemistry * hydrogenation efficiency Subject RIV: CA - Inorganic Chemistry Impact factor: 5.771, year: 2015