WorldWideScience

Sample records for madness eoliennes nouveau

  1. Art Nouveau i Skt. Petersborg

    DEFF Research Database (Denmark)

    Trier Mørch, Andreas

    2010-01-01

    Omhandler de fire smukkeste art nouveau bygninger i Skt. Petersborg. De to første: Singer bygningen og Jelisejevs Købmandsbutik har begge hentet deres inspiration fra den midt-europæiske tradition og de to sidste: Vitebsk Banegården og Revolutionsmuseet er hybrider mellem denne og den skandinaviske...... - eller rettere finske - art nouveau....

  2. Mad Cow Disease

    Science.gov (United States)

    ... Safe Videos for Educators Search English Español Mad Cow Disease KidsHealth / For Teens / Mad Cow Disease What's ... are people to get it? What Is Mad Cow Disease? Mad cow disease is an incurable, fatal ...

  3. [Madness in Foucault: art and madness, madness and unreason].

    Science.gov (United States)

    Providello, Guilherme Gonzaga Duarte; Yasui, Silvio

    2013-10-01

    After presenting the ideas on madness and its interface with art as expressed in the writings of Michel Foucault, Peter Pál Pelbart, and Gilles Deleuze, the article explores how these authors question the relationship between art and madness. It begins with the notion that madness does not tell the truth about art, and vice versa, but that there are links between both that must be delved into if we are to engage in deeper reflection on the topic. The text problematizes the statement that madness is the absence of an oeuvre and examines how this impacts the possibility of achieving an artistic oeuvre. It further problematizes the idea of madness as excluded language, that is, the idea that madness implies not only the exclusion of the body but also the disqualification of discourse.

  4. Mad Cow Disease (For Parents)

    Science.gov (United States)

    ... Safe Videos for Educators Search English Español Mad Cow Disease KidsHealth / For Parents / Mad Cow Disease What's ... Is Being Done About It Print About Mad Cow Disease Mad cow disease has been in the ...

  5. EOLICARE project: airborne wind turbine; Projet EOLICARE: eolienne aeroportee

    Energy Technology Data Exchange (ETDEWEB)

    Benhaiem, Pierre

    2010-09-15

    1 -- Introduction : a) General context b) Actual schematics of wind energy c)Towards a method for converting upper-level winds energy d) Planned airborne operating systems using kites. 2 - Study of the method called OrthoKiteBunch (OKB) :a) Technical aspects and comments of schematics in appendix b) Advantages and estimated costs) 3 - System implementation of OKB in the energy mix, study of synergies and possible complementarities :a) OKB installations-thermal plant b) Nuclear installation-OKB. 4 - Conclusion. References. Schematics. Appendices. Illustrations. [French] 1 -- Introduction : a) Contexte general b) Schemas actuels de l'energie eolienne c)Vers une methode de conversion de l'energie des vents de haute altitude d) Systemes d'exploitation aeroportes envisages mettant en oeuvre des cerfs-volants. 2 - Etude de la methode dite OrthoKiteBunch (OKB) :a) Aspects techniques et commentaires des schemas en annexe b) Avantages et couts estimes) 3 - Implantation du systeme OKB au sein du bouquet energetique,etude des synergies et complementarites possibles :a) Installations OKB-centrale thermique b) Installations nucleaire-OKB. 4 - Conclusion.References.Schemas annexes.Illustrations.

  6. Rundt om Mad Men

    DEFF Research Database (Denmark)

    Nielsen, Jakob Isak

    2011-01-01

    Artiklen gør rede for Mad Mens tilblivelse, dens populærkulturelle efterdønninger, multimediale forgreninger og værkæstetiske karakteristika. "Story Matters Here" lyder AMCs motto, men Mad Men tilbyder et bredspektret engagement, der går langt ud over at følge med i en vedkommende fortælling...

  7. Mad Cow Disease

    Indian Academy of Sciences (India)

    Mad Cow Disease, or bovine spongiform encephalopathy (BSE) is one of ... humoral immunity is developed against such infections. ... Most infecti ve agents, ranging from the more complex protozoans to bacteri(! and viruses, contain nucleic.

  8. MADS Users' Guide

    Science.gov (United States)

    Moerder, Daniel D.

    2014-01-01

    MADS (Minimization Assistant for Dynamical Systems) is a trajectory optimization code in which a user-specified performance measure is directly minimized, subject to constraints placed on a low-order discretization of user-supplied plant ordinary differential equations. This document describes the mathematical formulation of the set of trajectory optimization problems for which MADS is suitable, and describes the user interface. Usage examples are provided.

  9. MAD Phasing with Krypton

    International Nuclear Information System (INIS)

    Cohen, A.

    2001-01-01

    Phasing of two proteins, the 17 kDa Fe protein myoglobin from sperm whale (P. catodon) and an 18 kDa protein (SP18) from green abalone (H. fulgens), using Kr-edge MAD with frozen crystals demonstrates the feasibility of this technique as a routine method for structure determination

  10. MadEvent: automatic event generation with MadGraph

    International Nuclear Information System (INIS)

    Maltoni, Fabio; Stelzer, Tim

    2003-01-01

    We present a new multi-channel integration method and its implementation in the multi-purpose event generator MadEvent, which is based on MadGraph. Given a process, MadGraph automatically identifies all the relevant subprocesses, generates both the amplitudes and the mappings needed for an efficient integration over the phase space, and passes them to MadEvent. As a result, a process-specific, stand-alone code is produced that allows the user to calculate cross sections and produce unweighted events in a standard output format. Several examples are given for processes that are relevant for physics studies at present and forthcoming colliders. (author)

  11. Madness as disability.

    Science.gov (United States)

    Gilman, Sander L

    2014-12-01

    How does society imagine mental illness? Does this shift radically over time and with different social attitudes as well as scientific discoveries about the origins and meanings of mental illness? What happens when we begin to think about mental illness as madness, as a malleable concept constantly shifting its meaning? We thus look at the meanings associated with 'general paralysis of the insane' in the nineteenth century and autism today in regard to disability. In this case study we examine the claims by scholars such as the anthropologist Emily Martin and the psychiatrist Kay Jamison as to the relationship between mental illness, disability and creativity. Today, the health sciences have become concerned with mental illness as a form of disability. How does this change the meaning of madness for practitioners and patients? © The Author(s) 2014.

  12. Madness in Shakespeare's Characters

    Directory of Open Access Journals (Sweden)

    Nuno Borja-Santos

    2014-10-01

    Full Text Available This paper begins with an introduction where the aims are explained: a psychopathological analysis of a Shakespearean character - Othello – followed by the discussion of the English dramatist’s importance in helping us understand madness in the emergent world of Renaissance. The main characteristics of Othello’s personality, which allowed the development of his jealousy delusion, are described. Finally, the conclusions underline the overlap of the symptoms developed by the character with the DSM-IV classification.

  13. [Surrealism and madness].

    Science.gov (United States)

    Flora, Κ

    2017-01-01

    This article attempts an approach of madness by surrealism, as reflected in the pathway of the surrealist movement. In the light of enlargement of the concept of mental illness and the experience of madness, an approach is being attempted regarding the early surrealist views as they precursory appear e.g. from the case of Hieronymus Bosch to the meeting of the dominant psychiatry and the surrealist movement in the 19th and 20th century. Then, the paper attempts to present the main positions of representatives of the movement, such as Breton, Dali and Kalas. These three surrealists were chosen among others, for this brief report, as the representatives of three remarkable moments in the surrealistic route. Breton introduces the element of fiction and hyper-reality while he questions the distinction between normal and abnormal element. Dali with his paranoid critical method reconciles actual representations with mythical and symbolic elements, breaking through the limits between objectivity and subjectivity. Kalas puts forward the social origin of insanity along with the fundamental surrealist notions of individual freedom and will. For a more complete understanding of this attempt, it was considered useful to include elements of the main views on madness from the standpoint of a critical approach in psychiatry and psychology. The surrealistic view seems to be close to this critical approach which is likely to have been affected by it on the level in which the movements and scientific fields meet and interact. The relationship between surrealism, the notion and expression of madness and the absurd seems to be inherent to the very development of the movement through its core and individual pursuits. In conclusion, the relationship between surrealism and the notion and expression of the madness and the absurd seems to be inherent to the very birth of the movement through its main positions and pursuits. The question of so-called reality, its overshoot and the vision of

  14. MAD parsing and conversion code

    International Nuclear Information System (INIS)

    Mokhov, Dmitri N.

    2000-01-01

    The authors describe design and implementation issues while developing an embeddable MAD language parser. Two working applications of the parser are also described, namely, MAD-> C++ converter and C++ factory. The report contains some relevant details about the parser and examples of converted code. It also describes some of the problems that were encountered and the solutions found for them

  15. MAD data collection - current trends

    International Nuclear Information System (INIS)

    Dementieva, I.; Evans, G.; Joachimiak, A.; Sanishvili, R.; Walsh, M. A.

    1999-01-01

    The multi-wavelength anomalous diffraction, or MAD, method of determining protein structure is becoming routine in protein crystallography. An increase in the number of tuneable synchrotrons beamlines coupled with the widespread availability position-sensitive X-ray detectors based on charged-coupled devices and having fast readout raised MAD structure determination to a new and exciting level. Ultra-fast MAD data collection is now possible. Recognition of the value of selenium for phasing protein structures and improvement of methods for incorporating selenium into proteins in the form of selenomethionine have attracted greater interest in the MAD method. Recent developments in crystallographic software are complimenting the above advances, paving the way for rapid protein structure determination. An overview of a typical MAD experiment is described here, with emphasis on the rates and quality of data acquisition now achievable at beamlines developed at third-generation synchrotrons sources

  16. evaluation du nouveau ne par cesarienne

    OpenAIRE

    MERAD, Atif Djelloul; BOUARFA, Wahiba

    2014-01-01

    L’étude rétrospective des dossiers montre un recueil des données anamnestiques peu satisfaisant. L’anamnèse reste l’élément essentiel qui permet de faire le point sur l’enfant nouveau-né adressé pour soins appropriés, elle doit retracer l’histoire de la grossesse jusqu’à l’accouchement. L’étude du profil de nos patientes montre que La césarienne concerne particulièrement les primipares qui représentent plus de la moitié de nos femmes. Le risque de césarienne augmente statistiquement lorsqu...

  17. [Travelers, mad, wandering].

    Science.gov (United States)

    Vaschetto, Emilio

    2014-01-01

    This article explores the notion of "wandering" through the use of some phenomena enrolled at the dawn of modernity such as the Rousseau dromomanie's philosopher and writer, the origin of the first mad traveler (Albert Dadas), epidemics of mad travelers Europe and romantic tourism (with renewed acquires significance in the "beat generation" of the twentieth century). These historical facts are "mounting" as play contemporary manifestations such as loss, disorientation, to lose one's way, and wandering without reducing them only to clinical psychosis. Readings of classic psychiatrists such as Régis, Foville, Sérieux and Capgras, Tissié, go hand in hand with the current readings of the philosopher Ian Hacking and critics of pop culture as S. Reynolds and D. Diederichsen, illustrating how the travel's phenomenon can make different subjective configurations depending on historical times. In conclusion it is noted that not only psychosis exposes the wandering soul of suffering but there are also subject positions (as will be exemplified in a clinical case) and go no further nesting wandering into human existence.

  18. MadGraph/MadEvent. The new web generation

    International Nuclear Information System (INIS)

    Alwall, J.

    2007-01-01

    The new web-based version of the automatized process and event generator MadGraph/MadEvent is now available. Recent developments are: New models, notably MSSM, 2HDM and a framework for addition of user-defined models, inclusive sample generation and on-line hadronization and detector simulation. Event generation can be done on-line on any of our clusters. (author)

  19. A direct role of Mad1 in the spindle assembly checkpoint beyond Mad2 kinetochore recruitment

    DEFF Research Database (Denmark)

    Kruse, Thomas; Larsen, Marie Sofie Yoo; Sedgwick, Garry G

    2014-01-01

    in the SAC beyond recruitment of C-Mad2 to kinetochores has not yet been addressed. Here, we show that Mad1 is required for mitotic arrest even when C-Mad2 is artificially recruited to kinetochores, indicating that it has indeed an additional function in promoting the checkpoint. The C-terminal globular...... domain of Mad1 and conserved residues in this region are required for this unexpected function of Mad1........ The conversion of O-Mad2 into C-Mad2 at unattached kinetochores is thought to be a key step in activating the SAC. The "template model" proposes that this is achieved by the recruitment of soluble O-Mad2 to C-Mad2 bound at kinetochores through its interaction with Mad1. Whether Mad1 has additional roles...

  20. Mad Honey Disease

    Directory of Open Access Journals (Sweden)

    Laurentiu Broscaru

    2017-11-01

    Full Text Available A 46-years old woman presented with acute onset of nausea, vomiting and prostration in the ER. She appeared ill and was poorly responsive to verbal stimuli. The physical examination showed a systolic blood pressure of 60 mmHg and a pulse of 40 bpm. ECG was notable for slight ST-elevations in the inferior leads. Right ventricular myocardial infarction with cardiogenic shock and bradycardia was suspected. Supportive therapy with catecholamines was initiated and a emergency coronary angiography was arranged. However, lab results showed normal troponin levels and a subsequent echocardiogram showed the absence of abnormal wall motions. By thorough history taking with the spouse it turned out that the patient had consumed a Turkish honey approximately an hour before the beginning of the symptoms. The patient made a full recovery within 24 hours with only supportive therapy. In retrospect the clinical presentation was highly indicative of poisoning with Grayanotoxins from a plant, Rhododendron, which is found as contaminant in some sorts of honey in the Black Sea area. A pollen analysis confirmed the presence of Rhododendron in a honey sample.  Historically this poisoning is mentioned over the millennia as mad honey disease. The ST-elevations in the ECG were a sign of early repolarization, a non-pathological finding.

  1. L'internet nouveau est dans les "starting-blocks"

    CERN Multimedia

    Jennotte, A

    2001-01-01

    De nombreux chercheurs trouvent internet trop lent et limité. C'est pourquoi, ils travaillent sur un nouveau réseau : le Grid. Le Grid permettra de mieux partager les ressources informatiques en réseau (1 page).

  2. Madness in Sartre's "The Room"

    NARCIS (Netherlands)

    Jongeneel, E.C.S.

    2009-01-01

    In "The Room," part of his short story collection, The Wall (1938), Jean-Paul Sartre investigates madness as an alternative way of bourgeois life and thus takes a stand in the contemporary debate on the existential status of mental illness. "The Room" is a case-study of a "limit situation," as well

  3. Abject Magic: Reasoning Madness in Justine Larbalestier's "Magic or Madness" Trilogy

    Science.gov (United States)

    Potter, Troy

    2013-01-01

    This paper explores the representation of magic and madness in Justine Larbalestier's "Magic or Madness" trilogy (2005-2007). Throughout the series, magic is constructed as an abject and disabling force that threatens to disable magic-wielders, either through madness or death. Despite being represented as a ubiquitous force, the…

  4. MADS-box gene evolution - structure and transcription patterns

    DEFF Research Database (Denmark)

    Johansen, Bo; Pedersen, Louise Buchholt; Skipper, Martin

    2002-01-01

    Mads-box genes, ABC model, Evolution, Phylogeny, Transcription patterns, Gene structure, Conserved motifs......Mads-box genes, ABC model, Evolution, Phylogeny, Transcription patterns, Gene structure, Conserved motifs...

  5. Elizabethan madness: on London's stage.

    Science.gov (United States)

    Dalby, J T

    1997-12-01

    During the reign of Elizabeth I (1558-1603) a renaissance of both literary and political history occurred. The stage was transformed from primitive echoes of the morality plays to a vibrant and diverse exploration of human endeavor and man's place in the universe. The titanic literary figure of Shakespeare today veils a group of friends and challengers whose pens strove for the same goal. The depiction of madness was ubiquitous during plays of this time and reflection on the views of this group of men gives us a more reliable insight into mental illness then and today.

  6. Madness Decolonized?: Madness as Transnational Identity in Gail Hornstein's Agnes's Jacket.

    Science.gov (United States)

    Miller, Gavin

    2017-02-13

    The US psychologist Gail Hornstein's monograph, Agnes's Jacket: A Psychologist's Search for the Meanings of Madness (2009), is an important intervention in the identity politics of the mad movement. Hornstein offers a resignified vision of mad identity that embroiders the central trope of an "anti-colonial" struggle to reclaim the experiential world "colonized" by psychiatry. A series of literal and figurative appeals makes recourse to the inner world and (corresponding) cultural world of the mad as well as to the ethno-symbolic cultural materials of dormant nationhood. This rhetoric is augmented by a model in which the mad comprise a diaspora without an origin, coalescing into a single transnational community. The mad are also depicted as persons displaced from their metaphorical homeland, the "inner" world "colonized" by the psychiatric regime. There are a number of difficulties with Hornstein's rhetoric, however. Her "ethnicity-and-rights" response to the oppression of the mad is symptomatic of Western parochialism, while her proposed transmutation of putative psychopathology from limit upon identity to parameter of successful identity is open to contestation. Moreover, unless one accepts Hornstein's porous vision of mad identity, her self-ascribed insider status in relation to the mad community may present a problematic "re-colonization" of mad experience.

  7. The richness of plants in Art Nouveau gardens

    Directory of Open Access Journals (Sweden)

    Krystyna Pudelska

    2015-07-01

    Full Text Available The turn of the 19th and the 20th centuries signified the appearance of a new trend in art called Art Nouveau in England, Stile floreale in Italy, and in Poland – secesja. It was an attempt to escape from the style that copied historical forms and set a new direction of development. The main inspiration for the creators of this period became nature, its asymmetry, variety of textures, subtle colors or smooth, and wavy lines. Artistic motifs were drawn from the richness of native flora and fauna. Flowering shrubs, perennials and creepers were especially inseparable decorative and compositional elements of a garden.  Secession had a significant impact on painting, sculpture, architecture, and garden design. The space surrounding people was treated comprehensively by blurring the boundaries between different arts. A multitude of shrubs – especially roses and lots of perennials such as Lilium, Iris, and Phlox, gave the impression of architecture immersing in the surrounding garden. The aim of the paper was to briefly analyze the Art Nouveau style and present the diversity of species used in the gardens of that period.

  8. Relationship with BSE (Mad Cow Disease)

    Science.gov (United States)

    ... Disease (CWD) Prion Diseases Relationship with BSE (Mad Cow Disease) Evidence Recommend on Facebook Tweet Share Compartir ... macaque monkeys inoculated with brain tissue obtained from cattle with BSE had clinical and neuropathological features strikingly ...

  9. Turned Back: Mad Men as Intermedial Melodrama

    Directory of Open Access Journals (Sweden)

    Monique Rooney

    2012-09-01

    Full Text Available This essay draws on definitions of gesture (Giorgio Agamben and Peter Brooks and catachresis (Peter Brooks, Jacques Derrida to examine the primacy of non-verbal signifiers as communicators of meaning in AMC’s Mad Men. Beginning with an analysis of Mad Men’s credit sequence, it draws attention to Mad Men’s use of gesture and catachresis in relation to melodrama’s privileging of non-verbal and naturalistic expression and its persistence as an intermedial mode that has moved back and forth between various media (theatre, novel, cinema, television and now digital formats. It argues that Mad Men’s melodramatic aesthetic is one that obliquely, and via a gestural and rhetorical ‘turned back’, communicates its relation to the past and the present.

  10. MAD-X Training Course – 2016

    CERN Multimedia

    2016-01-01

    MAD-X 2016 is a annual course series at CERN, within the framework of the 2016 Technical Training Programme on the MAD-X tool used around the world for designing, studying and simulating beam physics for particle accelerators. The lecturer is Laurent Deniau from BE-APB, who has led the MAD team since 2011.    Two courses are available: Methodical Accelerator Design MAD-X: Beginners Session: 1-2 March (half day: mornings)   Methodical Accelerator Design MAD-X: Intermediate Session: 10-11 March (half day: mornings) Target audience: Designed for those needing to become familiar with and acquire some practical experience of particle accelerator design with MAD-X. Pre-requirements: The course requires some prior knowledge of accelerators and beam physics (e.g. optics) as the theory is not detailed. The series will be composed of 4 half-day lectures, given in English with questions and answers also possible in French. Participation in all lectures ...

  11. IBA of iridescent Art Nouveau glass - comparative studies

    International Nuclear Information System (INIS)

    Maeder, M.; Jembrih-Simbuerger, D.; Neelmeijer, C.; Schreiner, Manfred

    2005-01-01

    Simultaneous PIXE, PIGE, and RBS in air were employed to characterise the surface structure of iridescent Art Nouveau glass artefacts produced around 1900 by Tiffany, USA and Loetz, Austria. Using PIXE and PIGE, the chemical composition of the bulk glass and the overlays was determined in a non-destructive manner. Furthermore, the combination of PIXE and RBS enabled the layer structure of the analysed glasses (bulk, overlays, and iridescent layers) and the thicknesses of the thin layers in the near-surface domain to be determined. The measurement and evaluation procedure is demonstrated on blue iridescent glass fragments of Tiffany and Loetz by way of example. The initial results showing similarities but also differences in the layered glass structure of Tiffany and Loetz objects are presented

  12. Alimentation du nouveau-ne et du nourrisson dans la region ...

    African Journals Online (AJOL)

    Alimentation du nouveau-ne et du nourrisson dans la region centrale du togo : pratiques familiales et communautaires avant la mise en oeuvre de la strategie « prise en charge integree des maladies de l'enfant »

  13. KERNEL MAD ALGORITHM FOR RELATIVE RADIOMETRIC NORMALIZATION

    Directory of Open Access Journals (Sweden)

    Y. Bai

    2016-06-01

    Full Text Available The multivariate alteration detection (MAD algorithm is commonly used in relative radiometric normalization. This algorithm is based on linear canonical correlation analysis (CCA which can analyze only linear relationships among bands. Therefore, we first introduce a new version of MAD in this study based on the established method known as kernel canonical correlation analysis (KCCA. The proposed method effectively extracts the non-linear and complex relationships among variables. We then conduct relative radiometric normalization experiments on both the linear CCA and KCCA version of the MAD algorithm with the use of Landsat-8 data of Beijing, China, and Gaofen-1(GF-1 data derived from South China. Finally, we analyze the difference between the two methods. Results show that the KCCA-based MAD can be satisfactorily applied to relative radiometric normalization, this algorithm can well describe the nonlinear relationship between multi-temporal images. This work is the first attempt to apply a KCCA-based MAD algorithm to relative radiometric normalization.

  14. Un mur contre la malaria : Du nouveau dans la prévention des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le nouveau site Web facilitera l'enregistrement des événements démographiques afin d'améliorer l'accès aux services pour tous. Le nouveau site Web et la nouvelle bibliothèque de ressources aideront à améliorer les systèmes d'information et d'enregistrement des faits d'état civil dans les pays en développement.

  15. Exit Planning at Anette's Mad APS

    DEFF Research Database (Denmark)

    Nellemann, Camilla

    2017-01-01

    This is a Danish version. The 60-year old Anette Hansen established her catering firm Anette's Mad in 2012. She wants to sell her company within 7 years but so far hasn't thought a lot about ownership transfer. Anette's Mad employs 5 people and has a yearly turnover of about DKK200,000. The company...... benefits from Anette's strong, local network. At this point, Anette has invested DKK1.5 million in her business which she hopes to get back once she sells the company. The question is how Anette can prepare her business for sale so that it may sell at the price that she aims at....

  16. Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint

    DEFF Research Database (Denmark)

    Sironi, L; Melixetian, M; Faretta, M

    2001-01-01

    Mad2 is a key component of the spindle checkpoint, a device that controls the fidelity of chromosome segregation in mitosis. The ability of Mad2 to form oligomers in vitro has been correlated with its ability to block the cell cycle upon injection into Xenopus embryos. Here we show that Mad2 forms...

  17. Cultural Mediators Seduced by Mad Men:

    DEFF Research Database (Denmark)

    Kristensen, Nete Nørgaard; Hellman, Heikki; Riegert, Kristina

    2017-01-01

    Based on theories about the role of cultural mediators in cultural production and using the TV series Mad Men as a case, this article investigates how cultural journalists in the Nordic countries have contributed to legitimizing “quality TV series” as a worthy field of aesthetic consumption. Key...

  18. Trans meets cis in MADS science

    NARCIS (Netherlands)

    Folter, de S.; Angenent, G.C.

    2006-01-01

    The interaction between a transcription factor and its binding site at the DNA is an integral part of transcriptional regulatory networks, which is fundamental for an understanding of biological processes. An example is the family of MADS domain transcription factors, which represent key regulators

  19. MADS goes genomic in conifers: towards determining the ancestral set of MADS-box genes in seed plants.

    Science.gov (United States)

    Gramzow, Lydia; Weilandt, Lisa; Theißen, Günter

    2014-11-01

    MADS-box genes comprise a gene family coding for transcription factors. This gene family expanded greatly during land plant evolution such that the number of MADS-box genes ranges from one or two in green algae to around 100 in angiosperms. Given the crucial functions of MADS-box genes for nearly all aspects of plant development, the expansion of this gene family probably contributed to the increasing complexity of plants. However, the expansion of MADS-box genes during one important step of land plant evolution, namely the origin of seed plants, remains poorly understood due to the previous lack of whole-genome data for gymnosperms. The newly available genome sequences of Picea abies, Picea glauca and Pinus taeda were used to identify the complete set of MADS-box genes in these conifers. In addition, MADS-box genes were identified in the growing number of transcriptomes available for gymnosperms. With these datasets, phylogenies were constructed to determine the ancestral set of MADS-box genes of seed plants and to infer the ancestral functions of these genes. Type I MADS-box genes are under-represented in gymnosperms and only a minimum of two Type I MADS-box genes have been present in the most recent common ancestor (MRCA) of seed plants. In contrast, a large number of Type II MADS-box genes were found in gymnosperms. The MRCA of extant seed plants probably possessed at least 11-14 Type II MADS-box genes. In gymnosperms two duplications of Type II MADS-box genes were found, such that the MRCA of extant gymnosperms had at least 14-16 Type II MADS-box genes. The implied ancestral set of MADS-box genes for seed plants shows simplicity for Type I MADS-box genes and remarkable complexity for Type II MADS-box genes in terms of phylogeny and putative functions. The analysis of transcriptome data reveals that gymnosperm MADS-box genes are expressed in a great variety of tissues, indicating diverse roles of MADS-box genes for the development of gymnosperms. This study is

  20. The pineapple AcMADS1 promoter confers high level expression in tomato and arabidopsis flowering and fruiting tissues, but AcMADS1 does not complement the tomato LeMADS-RIN (rin) mutant

    Science.gov (United States)

    A previous EST study identified a MADS box transcription factor coding sequence, AcMADS1, that is strongly induced during non-climacteric pineapple fruit ripening. Phylogenetic analyses place the AcMADS1 protein in the same superclade as LeMADS-RIN, a master regulator of fruit ripening upstream of e...

  1. Cloning and Functional Analysis of the MADS-box CiMADS9 Gene from Carya illinoinensis

    Directory of Open Access Journals (Sweden)

    Zhang Jiyu

    2015-07-01

    Full Text Available A MADS-box gene, CiMADS9, was cloned from the male flowers of Carya illinoinensis by rapid amplification of cDNA ends. The gene was 1 077 bp with a 768 bp open reading frame encoding 255 amino acids. Multiple sequence comparisons revealed that CiMADS9 is a typical MIKC-type MADS-box gene with a MADS-box domain and a K semi-conserved region. Phylogenetic analysis indicated that CiMADS9 belongs to the AGL15 group of the MADS-box gene family. Quantitative reverse transcription polymerase chain reaction analysis indicated that the expression levels in reproductive organs (i.e., flowers and young fruits were considerably higher than in vegetative tissues (i.e., leaves and branches. The highest expression levels were observed in male flowers. An overexpression vector for CiMADS9 was constructed and the gene was inserted into the Arabidopsis thaliana genome. CiMADS9 expression was confirmed in all transgenic lines. Compared with wild-type plants, transgenic A. thaliana plants overexpressing CiMADS9 exhibited delayed flowering and an increased number of leaves.

  2. MAD-X progress and future plans

    CERN Document Server

    Deniau, L

    2012-01-01

    The design efforts for the High Luminosity upgrade of the Large Hadron Collider (HL-LHC) will require significant extensions of the MAD-X code widely used for designing and simulating particles accelerators. These changes are framed into a global redesign of the MADX architecture meant to consolidate its structure, increase its robustness and flexibility, and improve its performance. Some examples of recent extensions to MAD-X like the RF-Multipole element will be presented. Improvement for models and algorithms selection providing better consistency of the results and a wider range of use will be discussed. The computation efficiency will also be addressed to profit better of modern technologies. In this paper, we will describe the last improvements and the future plans of the project.

  3. Evaluation of the aerodynamic performances of a new vertical axis wind turbine type derived from the Savonius rotor; Prevision des performances aerodynamiques d'un nouveau type d'eolienne a axe vertical derivee du rotor Savonius

    Energy Technology Data Exchange (ETDEWEB)

    Jean-Luc Menet [Ecole Nationale Superieure d' Ingenieurs en Informatique Automatique Mecanique energetique electronique de Valenciennes, Universite de Valenciennes, Le Mont Houy F-59313 Valenciennes Cedex 9, (France); Andrew Leiper [Department of Engineering, University of Aberdeen, Aberdeen, Scotland (United Kingdom)

    2005-07-01

    The Savonius rotor is a slow running vertical axis wind turbine, the advantages of which are numerous; however, it has a poor aerodynamic efficiency. We present a study aiming to raise this efficiency by adjusting several geometrical parameters, in particular the overlap of the paddles and their respective position. The results are coming from a bidimensional numerical simulation, using the CFD code Fluent v6.0. First the numerical model is validated on the conventional Savonius rotor. Then the geometry of an optimised Savonius rotor is proposed, the overlap ratio of which is 0.242. Last a different positioning of the paddles leads to an optimal paddle angle of about 55 degrees, corresponding to the maximum of the mean starting torque coefficient. (authors)

  4. California and Irony in Mad Men

    OpenAIRE

    Taveira, Rodney

    2012-01-01

    The combination of melodramatic and art cinematic techniques and influences in AMC’s television series Mad Men (2007¬–) reveals how a melodramatic televisuality can image novel modes of social and intimate relations and an alternative to the archetypal American narrative of the self-made man. Set in 1960s’ America, the series uses a contemporaneous and cosmopolitan California to triangulate the formal and narrative insistence of the past on the present. This triangulation is played out by Don...

  5. Automated MAD and MIR structure solution

    International Nuclear Information System (INIS)

    Terwilliger, Thomas C.; Berendzen, Joel

    1999-01-01

    A fully automated procedure for solving MIR and MAD structures has been developed using a scoring scheme to convert the structure-solution process into an optimization problem. Obtaining an electron-density map from X-ray diffraction data can be difficult and time-consuming even after the data have been collected, largely because MIR and MAD structure determinations currently require many subjective evaluations of the qualities of trial heavy-atom partial structures before a correct heavy-atom solution is obtained. A set of criteria for evaluating the quality of heavy-atom partial solutions in macromolecular crystallography have been developed. These have allowed the conversion of the crystal structure-solution process into an optimization problem and have allowed its automation. The SOLVE software has been used to solve MAD data sets with as many as 52 selenium sites in the asymmetric unit. The automated structure-solution process developed is a major step towards the fully automated structure-determination, model-building and refinement procedure which is needed for genomic scale structure determinations

  6. A case of acute hepatitis following mad honey ingestion

    Directory of Open Access Journals (Sweden)

    Fatma Sari Dogan

    2015-12-01

    Full Text Available Acute hepatitis is characterized by liver inflammation and liver cell necrosis. The most frequently observed underlying cause thereof is viruses, but various other causes, such as alcohol, medication, or toxins may also lead thereto.In this paper, a case of acute hepatitis presenting with bradycardia, hypotension, and a prominent increase in liver enzymes following mad honey ingestion is discussed. Since there are only few cases of acute hepatitis following mad honey ingestion in the literature, we want to present this subject matter. Keywords: Mad honey poisoning, Mad honey intoxication, Bradycardia, Hypotension, Acute hepatitis

  7. Nouveau partenariat pour le développement de l'Afrique | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    22 juil. 2011 ... Devant elle, la promesse d'un avenir meilleur lui est offerte par le Nouveau partenariat pour le développement de l'Afrique (NEPAD), un plan radical qui offre ... Les populations africaines réclament de vraies élections, un débat public plus libre et un gouvernement plus responsable et respectueux des lois.

  8. Un nouveau centre de recherche soutient les efforts d'adaptation ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    9 juil. 2014 ... Image satellite du delta du Nil. José Alberto Gonçalves Pereira. Entretien avec. Mohamed Abdrabo est le directeur général de l'Alexandria Research Centre for Adaptation to Climate Change (ARCA), un nouveau centre de recherche qui soutient les politiques d'adaptation adoptées par le gouvernement ...

  9. Un nouveau centre de recherche soutient les efforts d'adaptation ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    9 juil. 2014 ... Mohamed Abdrabo est le directeur général de l'Alexandria Research Centre for Adaptation to Climate Change (ARCA), un nouveau centre de recherche qui soutient les politiques d'adaptation adoptées par le gouvernement égyptien au regard du delta du Nil.

  10. MADS interactomics : towards understanding the molecular mechanisms of plant MADS-domain transcription factor function

    NARCIS (Netherlands)

    Smaczniak, C.D.

    2013-01-01

    Protein-protein and protein-DNA interactions are essential for the molecular action of transcription factors. By combinatorial binding to target gene promoters, transcription factors are able to up- or down-regulate the expression of these genes. MADS-domain proteins comprise a large family of

  11. Interdisciplinary Critical Inquiry: Teaching about the Social Construction of Madness

    Science.gov (United States)

    Connor-Greene, Patricia A.

    2006-01-01

    Theories and treatments of mental illness reflect the social, philosophical, and historical context in which they developed. This article describes ways to invite students to grapple with complex questions about "madness" from an interdisciplinary perspective. Looking at the construct of madness through multiple lenses (e.g., literature,…

  12. Bovine Spongiform Encephalopathy (BSE, Mad Cow Disease

    Directory of Open Access Journals (Sweden)

    G. K. Bruckner

    1997-07-01

    Full Text Available Mad Cow Disease or BSE (Bovine Spongiform Encephalopathy became a household name internationally and also in South Africa. International hysteria resulted following reports of a possible link between a disease diagnosed in cattle in Britain and a variant of the disease diagnosed in humans after the presumed ingestion or contact with meat from infected cattle. The European Union instituted a ban on the importation of beef from the United Kingdom during March 1996 that had a severe effect on the beef industry in the UK and also resulted in a world wide consumer resistance against beef consumption.

  13. Web life: The Evil Mad Scientist Project

    Science.gov (United States)

    2009-04-01

    What is it? Have you ever tried to electrocute a hot dog? Wondered how to make a robot out of a toothbrush, watch battery and phone-pager motor? Seen a cantaloupe melon and thought, "Hmm, I could make this look like the Death Star from the original Star Wars films"? If you have not, but you would like to - preferably as soon as you can find a pager motor - then this is the site for you. The Evil Mad Scientist Project (EMSP) blog is packed full of ideas for unusual, silly and frequently physics-related creations that bring science out of the laboratory and into kitchens, backyards and tool sheds.

  14. Zsolnai Állami Főreáliskola, Art Nouveau Building and its Painted Decorations

    Directory of Open Access Journals (Sweden)

    Grúňová Zuzana

    2017-06-01

    Full Text Available The historic art nouveau building of the former high school in Žilina - Zsolnai Állami Főreáliskola - is nowadays one of the University of Žilina buildings. Empty, awaiting much needed renovation is school building a subject of the various researches of its art-historical and architectural features. Paper deals with wall painting as a one type decoration among preserved ones in this building. Lack of funds during its initial building and decoration works created rather limited amount motifs and simple technologies. If the whole scope of architectural works of Orth and Somló architectural studio (and the whole set of art nouveau buildings in Žilina is taken into account, even these simple, but elegant painting in well thought palette of colours could be valuable basis for renovation.

  15. Zsolnai Állami Főreáliskola, Art Nouveau Building and its Painted Decorations

    Science.gov (United States)

    Grúňová, Zuzana; Borošová Michalcová, Miloslava

    2017-06-01

    The historic art nouveau building of the former high school in Žilina - Zsolnai Állami Főreáliskola - is nowadays one of the University of Žilina buildings. Empty, awaiting much needed renovation is school building a subject of the various researches of its art-historical and architectural features. Paper deals with wall painting as a one type decoration among preserved ones in this building. Lack of funds during its initial building and decoration works created rather limited amount motifs and simple technologies. If the whole scope of architectural works of Orth and Somló architectural studio (and the whole set of art nouveau buildings in Žilina) is taken into account, even these simple, but elegant painting in well thought palette of colours could be valuable basis for renovation.

  16. Fag Men: Mad Men, Homosexuality and Televisual Style

    OpenAIRE

    Wallace, Lee

    2012-01-01

    Among the many retro-fittings achieved by Mad Men—Matthew Weinerʼs still unfurling television series set in the advertising world of the early 1960s—is the representation of the homosexual closet as a thing of the past. This essay approaches Mad Men’s account of the homophobic past in order to think about sexuality and televisual style. A landmark programme coterminous with American television transferring from analogue to digital signal, Mad Men allegorizes another moment in television histo...

  17. Développement d'un nouveau vaccin contre la PPCC à partir d'une ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les chèvres seront vaccinées à l'aide du nouveau vaccin recombinant vivant ou inactivé, puis infectées de façon expérimentale par la bactérie Mccp afin de déterminer si le vaccin offre une protection. Ce projet utilisera des outils de biologie synthétique de pointe pour mettre au point un vaccin contre la PPCC qui se ...

  18. 'The verses of madness': schizophrenia and poetry.

    Science.gov (United States)

    Hankir, Ahmed Khaldoon; Holloway, David; Agius, Mark; Zaman, Rashid

    2012-12-20

    In the early 19th century, Lombroso introduced the concept of hereditary taint to describe the coexistence of 'madness' and creativity. In a recent investigation, Rust et al reported a study designed to test the traditionally assumed relationship between creativity and schizophrenia. They uncovered an association between creative originality and the positive cognitive aspects of schizotypal thinking. Poetry is not only the 'product' of psychopathology but it can also be utilised as a form of therapy: "My name is David Holloway, I am a 33 year old poet/blogger with paranoid schizophrenia. A poet called Charles Bukowski has described poetry as the 'ultimate psychiatrist', and I am a firm believer in this. The strongest part of my personality is my belief in the power of love. My recovery has relied heavily on medication, diet and exercise. However it is the power of poetry that has been my true inspiration."

  19. Recent developments in MAD version 8

    International Nuclear Information System (INIS)

    Grote, H.; Iselin, F.C.

    1990-01-01

    In view of experience with the language decoder and memory manager, large parts of MAD have been rewritten recently. The dynamic memory manager is replaced by the CERN-written ZEBRA package which has been used successfully in more than 100 other programs for HEP data analysis. A new dynamic table handler keeps large tables in memory as long as they fit; it dumps them on disk or to the Cray SSD (solid-state storage device) if necessary. Tables are accessed by simple subroutine calls in a manner transparent to the user. The input language has been extended to use a more object-oriented approach. Accelerator elements are described in terms of classes of objects, providing easy selection of single elements in a large machine. A powerful mechanism has been implemented for writting tables of selected optical functions and/or element parameters in selected positions of the machine. These tables are generated and written under control of the table handler, and can be read directly by the LEP control system. MAD contains a plot module with various options to plot data from internal tables. The tables can also be fed into a stand-alone plot program. At present the following program modulus are complete: Command Decoder; Optical Functions Calculation; Closed-Orbit Correction; Harmon (chromaticity calculation); Plotting. It is foreseen that by the end of 1989 the following other modules will be ready: Matching, including some new features; Lie Algebraic Analysis: Tracking by TRANSPORT and Lie Algebraic Methods; Electron Beam Parameters; Polarization. (orig.)

  20. Bovine Spongiform Encephalopathy (BSE), or Mad Cow Disease

    Science.gov (United States)

    ... the CDC Bovine Spongiform Encephalopathy (BSE), or Mad Cow Disease Note: Javascript is disabled or is not ... spongiform encephalopathy) is a progressive neurological disorder of cattle that results from infection by an unusual transmissible ...

  1. VLT-MAD Observations of Trumpler 14

    Science.gov (United States)

    Rochau, B.; Brandner, W.; Stolte, A.; Henning, T.; da Rio, N.; Gennaro, M.; Hormuth, F.; Marchetti, E.; Amico, P.

    We present H and KS observations of the young massive cluster Trumpler 14 obtained with the MCAO system VLT-MAD which provides homogeneous Strehl ratios over a large field of view. We derived maximum Strehl ratios of 9.8% and 12.6% with mean Strehl ratios of 6.0% and 5.9% with in H and K_S, respectively, revealing significant improvement of the spatial PSF stability compared to SCAO systems. We detected 2-3 times more sources than comparable seeing-limited observations, and comparison of the colour-magnitude diagram with isochrones reveals a very young cluster that originated in a starburst-like event 1 ± 0.5 Myr ago. We also tentatively detect hints for an older population of 3 Myr. The mass function between 0.25 Msun and 3.2 Msun appears as a broken power law with a change of the power law slope at m_c ˜ 0.53+0.12-0.10 Msun. Shallow power law slopes are found to be Gamma_{PD,PMS1} = ˜ 0.48 ± 0.11 above m_c and Gamma_{PD,PMS2} = 0.68 ± 0.30 below m_c.

  2. California and Irony in Mad Men

    Directory of Open Access Journals (Sweden)

    Rodney Taveira

    2012-09-01

    Full Text Available The combination of melodramatic and art cinematic techniques and influences in AMC’s television series Mad Men (2007¬– reveals how a melodramatic televisuality can image novel modes of social and intimate relations and an alternative to the archetypal American narrative of the self-made man. Set in 1960s’ America, the series uses a contemporaneous and cosmopolitan California to triangulate the formal and narrative insistence of the past on the present. This triangulation is played out by Don Draper’s relations with his family, women, and his former identities and by the representation of homosexuality throughout the series. The application of Lee Edelman’s concept of “sinthomosexuality” and Richard Rorty’s “liberal ironist” reveal a queer, visual rhetoric to the show’s narrative and formal structures, forming a queer irony that allows the show to straddle the aesthetic extremes of “quality TV” (Jane Feuer and soap opera, which, in turn, queers the exemplary American heterosexuality of Don Draper.

  3. The design of the MAD Design Program

    International Nuclear Information System (INIS)

    Niederer, J.

    1992-01-01

    The study of long term stability in particle accelerators has long been served by a group of widely circulated computer programs. The progress in these programs has mirrored the growth and versatility in accelerator size, complexity, and purpose, as well as evolving technologies in computing software and hardware. A number of large accelerator projects during the last decade were designed with the aid of physics programs either written for, or tailored for the project at hand, each invariably benefiting from contributions of previous workers. This paper outlines the recent history of of expample of an accelerator lattice model tool kit, the Methodical Accelerator Design (MAD) Program, which has tried to knit together this collective wisdom of the accelerator community, The ideas behind the software design of the program itself are traced here; the accelerator physics contents and origins are thoroughly documented elsewhere. These informal notes have a Brookhaven flavor, in part because of early BNL efforts to generalize the ways that technical problems are organized and presented to computers. Some recent BNL applications not covered in the extensive CERN documentation are also included

  4. Mapping bipolar worlds: lived geographies of 'madness' in autobiographical accounts.

    Science.gov (United States)

    Chouinard, Vera

    2012-03-01

    This article aims to advance our understanding of women's and men's experiences of negotiating bipolar 'madness' in society and space. It addresses gaps in the clinical literature on life with bipolar and geographic accounts of 'madness' and psycho-emotional distress by considering altered ways of being in place that bipolar 'madness' entails and how narrative sense is made of these. Conceptually, I build on Cosgrove's (2000) approach to psycho-emotional distress and geographic insights about being 'mad' in place. Methodologically and empirically, I draw on thematic narrative analysis of autobiographies of living with bipolar. Key findings include altered paradoxically (dis)embodied ways of being-in-place, 'fractured' or 'whole' senses of self and ways of relating to people/places, 'straddling' 'real' and 'delusional' worlds and bipolar ways of negotiating places are not straightforwardly 'irrational'. While narrative accounts most often invoke dominant discourses about bipolar, sometimes these are challenged through 'rescripting' and 'revaluing mad' identities and ways of being in place. In conclusion, key findings and avenues for future geographical research are discussed. Copyright © 2011 Elsevier Ltd. All rights reserved.

  5. [Madness in the German cinema (1913-1933].

    Science.gov (United States)

    Aulas, J J

    1980-01-01

    During these twenty years, from 1913 to 1933, of the history of the German cinema, the cinematographic representation of madness varies according to the fluctuations of the social and economical background. The political and ideological chaos of the immediate post-war years was symbolized in the allegorical imagery of unreason in the expressionist cinema. The same equivalence, the same symbolization can be found in the cinema of the thirties when the crash of Wall-Street foretells a crisis like the former. On the contrary in the course of the so-called "relative stabilization" (1924-1929) the meaning of the representation of madness is totally different from the representation of the previous period. At this period of economical restoration, madness which could henceforth be cured on the psychoanalyst's couch (acc. G. W. Pabst's film: "Geheimnisse einer Seele") became the symbol of the absolute power rediscovered by Germany.

  6. Poetic Recuperations: The Ideology and Praxis of Nouveau Réalisme

    Directory of Open Access Journals (Sweden)

    Roberdeau, Wood

    2012-08-01

    Full Text Available Taking previously un-translated writings of critic Pierre Restany as a primary source, this article demonstrates how his vision for the Nouveau Réaliste movement of the 1950s and 1960s demands a detailed and theoretical (rather than historically contextual exploration of its attempt to reconcile visual art with the quotidian. Accordingly, Bürger's criticism of the historical and neo-avant-gardes is weighed against theories of aesthetics and politics from Adorno to Rancière. In addition, Heidegger's work on the art object, alongside Benjamin's interest in Hölderlin, serves to inform an analysis of Restany's investment in a concept of the 'poetry of the real'. Individual works by Niki de Saint-Phalle, Daniel Spoerri and Yves Klein are also investigated as exemplars of the Nouveau Réaliste ideology. My interest in Restany's life and work stems from recent art world concentrations on the banal or 'infra-ordinary' and its relation to similar concerns within sociology.

  7. 33 CFR 147.839 - Mad Dog Truss Spar Platform safety zone.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Mad Dog Truss Spar Platform... SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.839 Mad Dog Truss Spar Platform safety zone. (a) Description. Mad Dog Truss Spar Platform, Green Canyon 782 (GC 782), located at position...

  8. MADS box genes expressed in developing inflorescences of rice and sorghum

    NARCIS (Netherlands)

    Greco, R.; Stagi, L.; Colombo, L.; Angenent, G.C.; Sari-Gorla, M.; Pé, M.E.

    1997-01-01

    With the aim of elucidating the complex genetic system controlling flower morphogenesis in cereals, we have characterized two rice and two sorghum MADS box genes isolated from cDNA libraries made from developing inflorescences. The rice clones OsMADS24 and OsMADS45, which share high homology with

  9. [The representation of madness in William Shakespeare's characters].

    Science.gov (United States)

    Stompe, Thomas; Ritter, Kristina; Friedmann, Alexander

    2006-08-01

    Shakespeare is one of the great creators of human characters of the 16(th) century. Like for many of his contemporaries madness was a central topic of his work. The first part of this paper discusses the sociocultural environment and the semantic field of madness in the Elizabethan age, which forms the background for Shakespeare's characters. In the second part we try to analyze the clinical pictures of the fictive characters of Othello, Hamlet, Lear and Macbeth. While we find melancholy, delusions and hallucinations, other diseases such as schizophrenia are missing entirely. Schizophrenia only appears in the literature more than two hundred years later, in the beginning of modern age.

  10. Don, Betty and Jackie Kennedy: On Mad Men and Periodisation

    Directory of Open Access Journals (Sweden)

    Prudence Black

    2012-09-01

    Full Text Available Why is it that we watch Mad Men and think it represents a period? Flashes of patterned wallpaper, whiskey neat, babies born that are never mentioned, contact lining for kitchen drawers, Ayn Rand, polaroids, skinny ties, Hilton hotels, Walter Cronkite, and a time when Don Draper can ask ‘What do women want?’ and dry old Roger Sterling can reply ‘Who Cares?’ This essay explores the embrace of period detail in Mad Men finding it to be both loving and fetishistic, and belonging, like all period film, to the politics of the present.

  11. Molecular cloning, identification, and chromosomal localization of two MADS box genes in peach (Prunus persica).

    Science.gov (United States)

    Zhang, Lin; Xu, Yong; Ma, Rongcai

    2008-06-01

    MADS box proteins play an important role in floral development. To find genes involved in the floral transition of Prunus species, cDNAs for two MADS box genes, PpMADS1 and PpMADS10, were cloned using degenerate primers and 5'- and 3'-RACE based on the sequence database of P. persica and P. dulcis. The full length of PpMADS1 cDNA is 1,071 bp containing an open reading frame (ORF) of 717 bp and coding for a polypeptide of 238 amino acid residues. The full length of PpMADS10 cDNA is 937 bp containing an ORF of 633 bp and coding for a polypeptide of 210 amino acid residues. Sequence comparison revealed that PpMADS1 and PpMADS10 were highly homologous to genes AP1 and PI in Arabidopsis, respectively. Phylogenetic analysis indicated that PpMADS1 belongs to the euAP1 clade of class A, and PpMADS10 is a member of GLO/PI clade of class B. RT-PCR analysis showed that PpMADS1 was expressed in sepal, petal, carpel, and fruit, which was slightly different from the expression pattern of AP1; PpMADS10 was expressed in petal and stamen, which shared the same expression pattern as PI. Using selective mapping strategy, PpMADS1 was assigned onto the Bin1:50 on the G1 linkage group between the markers MCO44 and TSA2, and PpMADS10 onto the Bin1:73 on the same linkage group between the markers Lap-1 and FGA8. Our results provided the basis for further dissection of the two MADS box gene function.

  12. The regulation of MADS-box gene expression during ripening of banana and their regulatory interation with ethylene

    Science.gov (United States)

    MADS-box genes (MaMADS1-6), potential components of the developmental control of ripening have been cloned from Grand Nain banana cultivar. Similarity of these genes to tomato LeRIN is very low and neither MaMADS2 nor MaMADS1 complement the tomato rin mutation. Nevertheless, the expression patterns...

  13. Le Peer to Peer: Vers un Nouveau Modèle de Civilization

    Directory of Open Access Journals (Sweden)

    Michel Bauwens

    2006-06-01

    Full Text Available Le « peer to peer » est la dynamique intersubjective caractéristique des réseaux distribués. Le but de cet essai est de montrer qu'il s'agit d'une véritable nouvelle forme d’organisation sociale, apte à produire et échanger des biens, à créer de la valeur. Celle-ci est la conséquence d'un nouvel imaginaire social, et possède le potentiel de devenir le pilier d'un nouveau mode d'économie politique, voire d'un nouveau type de civilisation. Pour cela, nous allons d'abord définir le P2P, décrire en bref ces manifestations, et le différencier d'autres modalités d'échange intersubjectif tel que le marché, la hiérarchie, l'économie du don.Comme principale modalité P2P nous distinguons: Les processus de production P2P, comme troisième mode de production, qui n'est ni géré par un mode hiérarchique ou par l'état, ni répondant à des impératifs de profit ou qui sont modulés par le biais des prix. Les processus de gouvernance P2P, qui gouverne ces processus de production. Les formes de propriété P2P, qui sont destine a empecher l’appropriation prive de cette production pour le commun.Afin d’examiner les characteristiques de cette nouvelle dynamique sociale, nous utilisons la typologie intersubjective de l’anthropologue Alan Page Fisque, qui distingue: 1. l'échange égalitaire (Equality Matching, c..a.d l’economie du don. 2. La relation d’autorité (Authority Ranking tel qu’elle s’exprime dans le mode hierarchique. 3. le marché (Market Pricing. 4. la participation commune (Communal Shareholding.En conclusion, nous examinons les possibilites d’expansion de ce nouveau mode sociale et son insertion dans l’economie capitaliste, en nous nous posons la question: le P2P peut-il etre concu comme alternative sociale et economique aux modeles existants.

  14. TrMADS3, a new MADS-box gene, from a perennial species Taihangia rupestris (Rosaceae) is upregulated by cold and experiences seasonal fluctuation in expression level.

    Science.gov (United States)

    Du, Xiaoqiu; Xiao, Qiying; Zhao, Ran; Wu, Feng; Xu, Qijiang; Chong, Kang; Meng, Zheng

    2008-06-01

    In many temperate perennial plants, floral transition is initiated in the first growth season but the development of flower is arrested during the winter to ensure production of mature flowers in the next spring. The molecular mechanisms of the process remain poorly understood with few well-characterized regulatory genes. Here, a MADS-box gene, named as TrMADS3, was isolated from the overwintering inflorescences of Taihangia rupestris, a temperate perennial in the rose family. Phylogenetic analysis reveals that TrMADS3 is more closely related to the homologs of the FLOWERING LOCUS C lineage than to any of the other MIKC-type MADS-box lineages known from Arabidopsis. The TrMADS3 transcripts are extensively distributed in inflorescences, roots, and leaves during the winter. In controlled conditions, the TrMADS3 expression level is upregulated by a chilling exposure for 1 to 2 weeks and remains high for a longer period of time in warm conditions after cold treatment. In situ hybridization reveals that TrMADS3 is predominantly expressed in the vegetative and reproductive meristems. Ectopic expression of TrMADS3 in Arabidopsis promotes seed germination on the media containing relatively high NaCl or mannitol concentrations. These data indicate that TrMADS3 in a perennial species might have its role in both vegetative and reproductive meristems in response to cold.

  15. Cloning and analysis of two Ceratopteris thalictroides MADS-box genes

    Directory of Open Access Journals (Sweden)

    XU Daolan

    2014-06-01

    Full Text Available MADS-box transcription factors,as a large gene family,play an important role in plant growth and development,especially act as key regulators in controlling the identities of floral organs in flowering plants.They are also significant in the evolutionary revelation.In order to understand MADS-box genes,we need more information of MADS-box genes in non flowering plant.MADS-box genes of Ceratopteris thalictroides were selected to clone and analysis by using RACE method.Two MADS-box genes,designated CtMADS1 and CtMADS2 in C. thalictroides,were cloned.Analysis indicates that CtMADS1 is belonged to MIKC*-clade,while CtMADS2 is belonged to MIKCc-clade.Phylogeny suggests that these two MADS-box genes of C. thalictroides have a close relationship with flowering plants,the data indicates that at least two different MADS-box genes are homologous to floral homeotic genes existed in the last common ancestor of contemporary vascular plants.

  16. Cassandra in the Classroom: Teaching and Moral Madness

    Science.gov (United States)

    Santoro, Doris A.

    2017-01-01

    Moral madness is a symptom of the moral violence experienced by teachers who are expected to exercise responsibility for their students and their work, but whose moral voice is misrecognized as self-interest and whose moral agency is suppressed. I conduct a feminist ethical analysis of the figure of Cassandra to examine the ways in which teachers…

  17. Reviewing the Link between Creativity and Madness: A Postmodern Perspective

    Science.gov (United States)

    Koh, Caroline

    2006-01-01

    Researchers on creativity and psychology have long been fascinated with the high incidence of psychotic behavior amongst geniuses and individuals of exceptional creativity. The aims of this paper are first, to review the existing findings for a better insight into the socio-contextual factors underpinning the mad genius conundrum, and secondly, to…

  18. [The madness of Herakles in Euripides and Sophocles].

    Science.gov (United States)

    Charlier, Philippe

    2003-01-01

    In the ancient Greek world madness was conceived as a punishment sent by the gods to men found guilty of various sins. Heralkes, who kills his wife Megara and their sons, is the best example of Greek literature offers of the tragic consequences of mental disease. The article conducts a medical observation of Sophocles' and Euripides' descriptions of Herakles' insanity.

  19. Music, madness and the body: symptom and cure.

    Science.gov (United States)

    MacKinnon, Dolly

    2006-03-01

    Building on Sander L. Gilman's exemplary work on images of madness and the body, this article examines images of music, madness and the body by discussing the persistent cultural beliefs stemming from Classical Antiquity that underpin music as medicinal. These images reflect the body engaged in therapeutic musical activities, as well as musical sounds forming part of the evidence of the mental diagnostic state of a patient in case records. The historiography of music as medicinal has been overlooked in the history of psychiatry. This article provides a brief background to the cultural beliefs that underlie examples of music as both symptom and cure in 19th- and 20th-century asylum records in Australia, Britain, Europe and North America.

  20. The world of Mad Men: power, surface and passion.

    Science.gov (United States)

    Gerson, Mary-Joan

    2011-12-01

    Mad Men is disturbing to post-millennium viewers, particularly those of a "certain" age, on three counts. First, it invokes a particular historical context of gender oppression; second it captures the prevailing post-War injunction that emotional distress is unseemly and distasteful; and third, it captures the zeitgeist's celebration of surface over substance in relationship. However, just as disturbing as these historically situated interpersonal premises is the niggling question that each relationship pairing and each episode leaves with the viewer. To wit: How much of the disconnection and the unrequited longings are reflective of a particular historical era, and to what degree do they reflect timeless aspects of character and relationship? Thus Mad Men provides an exquisitely rendered sociocultural tableau in which the viewer struggles, however articulated or not, with one of the essential knots of psychoanalytic as well as couples treatment: the complicated interpenetration of culture and character, of time and timelessness.

  1. Extensions of MAD Version 8 to Include Beam Acceleration

    International Nuclear Information System (INIS)

    Raubenheimer, Tor O

    2000-01-01

    In this paper, the authors describe modifications to MAD version 8.23 to include linear accelerator cavities and beam acceleration. An additional energy variable has been added which is modified as the beam passes through LCAV elements (linear accelerator cavities) and can be used as a constraint in matching commands. The calculation of the beta functions and phase advance is consistent with that in other codes that treat acceleration such as TRANSPORT or DIMAD. These modifications allow this version of MAD to be used for the design and modeling of linacs and the authors present examples from the Next Linear Collider design as well as a muon acceleration complex. The code is available from CERN or SLAC

  2. Slow ventricular response atrial fibrillation related to mad honey poisoning

    Science.gov (United States)

    Osken, A.; Yaylacı, S.; Aydın, E.; Kocayigit, İ; Cakar, M.A.; Tamer, A.; Gündüz, H.

    2012-01-01

    Mad honey poisoning which is induced by Grayanotoxin (Andromedotoxin), is also known to have adverse effects in the cardiovascular system leading to different clinical entities. This toxin is produced by a member of the Rhododendron genus of plants of two R. Luteum and R. Panticum. In this article, we presented a case of slow ventricular response atrial fibrillation complaints with nausea, vomiting, dizziness and chest pain about an hour after eating honey produced in the Black Sea Region. PMID:22923947

  3. Slow ventricular response atrial fibrillation related to mad honey poisoning

    OpenAIRE

    Osken, A.; Yaylacı, S.; Aydın, E.; Kocayigit, İ; Cakar, M.A.; Tamer, A.; Gündüz, H.

    2012-01-01

    Mad honey poisoning which is induced by Grayanotoxin (Andromedotoxin), is also known to have adverse effects in the cardiovascular system leading to different clinical entities. This toxin is produced by a member of the Rhododendron genus of plants of two R. Luteum and R. Panticum. In this article, we presented a case of slow ventricular response atrial fibrillation complaints with nausea, vomiting, dizziness and chest pain about an hour after eating honey produced in the Black Sea Region.

  4. Fag Men: Mad Men, Homosexuality and Televisual Style

    Directory of Open Access Journals (Sweden)

    Lee Wallace

    2012-09-01

    Full Text Available Among the many retro-fittings achieved by Mad Men—Matthew Weinerʼs still unfurling television series set in the advertising world of the early 1960s—is the representation of the homosexual closet as a thing of the past. This essay approaches Mad Men’s account of the homophobic past in order to think about sexuality and televisual style. A landmark programme coterminous with American television transferring from analogue to digital signal, Mad Men allegorizes another moment in television history when the medium was defined not by convergence and time-shifting but by liveness, scheduling flow, mass-market demographics and synchronous viewing. Though it confines its gay content to minor characters and narrative arcs that phase in and out in relation to open-ended long-form needs, the programme’s representation of homophobia as a thing of the past provides a useful lens on the complex temporal co-ordinates of contemporary television.

  5. Le Peer to Peer: Vers un Nouveau Modèle de Civilisation

    Directory of Open Access Journals (Sweden)

    Michel Bauwens

    2006-06-01

    Full Text Available Le « peer to peer » est la dynamique intersubjective caractéristique des réseaux distribués. Le but de cet essai est de montrer qu’il s’agit d’une véritable nouvelle forme d’organisation sociale, apte à produire et échanger des biens, à créer de la valeur. Celle-ci est la conséquence d’un nouvel imaginaire social, et possède le potentiel de devenir le pilier d’un nouveau mode d’économie politique, voire d’un nouveau type de civilisation. Pour cela, nous allons d’abord définir le P2P, décrire en bref ces manifestations, et le différencier d’autres modalités d’échange intersubjectif tel que le marché, la hiérarchie, l’économie du don. Comme principale modalité P2P nous distinguons: Les processus de production P2P, comme troisième mode de production, qui n’est ni géré par un mode hiérarchique ou par l’état, ni répondant à des impératifs de profit ou qui sont modulés par le biais des prix. Les processus de gouvernance P2P, qui gouverne ces processus de production. Les formes de propriété P2P, qui sont destine a empecher l’appropriation prive de cette production pour le commun. Afin d’examiner les characteristiques de cette nouvelle dynamique sociale, nous utilisons la typologie intersubjective de l’anthropologue Alan Page Fisque, qui distingue: 1. l’échange égalitaire (Equality Matching, c..a.d l’economie du don. 2. La relation d’autorité (Authority Ranking tel qu’elle s’exprime dans le mode hierarchique. 3. le marché (Market Pricing. 4. la participation commune (Communal Shareholding. En conclusion, nous examinons les possibilites d’expansion de ce nouveau mode sociale et son insertion dans l’economie capitaliste, en nous nous posons la question: le P2P peut-il etre concu comme alternative sociale et economique aux modeles existants. Abstract: “Peer to peer” is hypothesized as a new social formation with intersubjective dynamics characteristic of distributed

  6. Validação da Échelle Douleur Inconfort Nouveau-Né para a cultura brasileira

    Directory of Open Access Journals (Sweden)

    Flávia de Souza Barbosa Dias

    2018-02-01

    Full Text Available RESUMO Objetivo Avaliar a confiabilidade e a validade da versão brasileira da Échelle Douleur Inconfort Nouveau-Né, que mensura a dor prolongada em recém-nascidos. Método Estudo metodológico realizado junto com recém-nascidos. Para a coleta foram utilizadas as versões brasileiras da Échelle Douleur Inconfort Nouveau-Né e da Children’s and Infants’ Postoperative Pain Scale. Para a confiabilidade, foram consideradas a equivalência, mensurada pela concordância entre observadores, e a homogeneidade. Para avaliar a validade, foi considerada a abordagem de construto convergente correlacionando as versões brasileiras da Échelle Douleur Inconfort Nouveau-Né e da Children’s and Infants’ Postoperative Pain Scale. Resultados Compuseram a amostra final 96 recém-nascidos. Na avaliação da confiabilidade, o coeficiente de concordância entre observadores variou entre 0,64 e 0,85 para os itens que compõem o instrumento e 0,96 para o escore total. O alfa de Cronbach foi de 0,82. Na avaliação da validade convergente, o coeficiente de correlação de Spearman entre os valores encontrados para as duas escalas foi de 0,79 (p< 0,0001. Conclusão A versão brasileira da Échelle Douleur Inconfort Nouveau-Né é um instrumento confiável e válido para avaliar a dor prolongada em recém-nascidos.

  7. Prognosis End-Time: Madness and Prophecy in Melancholia and Take Shelter

    Directory of Open Access Journals (Sweden)

    Briohny Doyle

    2013-05-01

    Full Text Available This paper discusses two films released in 2011, Lars Von Trier's Melancholia and Jeff Nichols Take Shelter in the context of the history of dominant conceptions of madness as laid out in Foucault's History of Madness. I argue that these films allegorise protagonists' experiences of depression and schizophrenia in order to critique the present moment in North America as well as to restore a poetic link between madness, prophecy and apocalypse in the popular imagination.

  8. The regulation of MADS-box gene expression during ripening of banana and their regulatory interaction with ethylene.

    Science.gov (United States)

    Elitzur, Tomer; Vrebalov, Julia; Giovannoni, James J; Goldschmidt, Eliezer E; Friedman, Haya

    2010-03-01

    Six MaMADS-box genes have been cloned from the banana fruit cultivar Grand Nain. The similarity of these genes to tomato LeRIN is low and neither MaMADS2 nor MaMADS1 complement the tomato rin mutation. Nevertheless, the expression patterns, specifically in fruit and the induction during ripening and in response to ethylene and 1-MCP, suggest that some of these genes may participate in ripening. MaMADS1, 2, and 3, are highly expressed in fruit only, while the others are expressed in fruit as well as in other organs. Moreover, the suites of MaMADS-box genes and their temporal expression differ in peel and pulp during ripening. In the pulp, the increase in MaMADS2, 3, 4, and 5 expression preceded an increase in ethylene production, but coincides with the CO(2) peak. However, MaMADS1 expression in pulp coincided with ethylene production, but a massive increase in its expression occurred late during ripening, together with a second wave in the expression of MaMADS2, 3, and 4. In the peel, on the other hand, an increase in expression of MaMADS1, 3, and to a lesser degree also of MaMADS4 and 2 coincided with an increase in ethylene production. Except MaMADS3, which was induced by ethylene in pulp and peel, only MaMADS4, and 5 in pulp and MaMADS1 in peel were induced by ethylene. 1-MCP applied at the onset of the increase in ethylene production, increased the levels of MaMADS4 and MaMADS1 in pulp, while it decreased MaMADS1, 3, 4, and 5 in peel, suggesting that MaMADS4 and MaMADS1 are negatively controlled by ethylene at the onset of ethylene production only in pulp. Only MaMADS2 is neither induced by ethylene nor by 1-MCP, and it is expressed mainly in pulp. Our results suggest that two independent ripening programs are employed in pulp and peel which involve the activation of mainly MaMADS2, 4, and 5 and later on also MaMADS1 in pulp, and mainly MaMADS1, and 3 in peel. Hence, our results are consistent with MaMADS2, a SEP3 homologue, acting in the pulp upstream of the

  9. The vocabulary of madness from Homer to Hippocrates. Part 1: the verbal group of mualphaiotanuomicronmualphaiota.

    Science.gov (United States)

    Perdicoyianni-Paléologou, Hélène

    2009-09-01

    In Part 1 of this two-part paper, I examine the evolution of the concept of madness expressed by the various forms--verbal and nominal, simple and compound--of the verbal group of mualphaiotanuomicronmualphaiota in the archaic and classical periods. I point out how the divine madness is contrasted to pathological madness considered as a psychic and mental disease and foreseeable by doctors as well as curable by medications. This new procedure highlights rational knowledge of the Greeks about the cause and the medical care of madness.

  10. Technical Training: Annonce de nouveau cours: Utilisation des fichiers PDF avec ACROBAT 6.0

    CERN Multimedia

    Monique Duval

    2005-01-01

    CERN Technical Training 2005: Learning for the LHC! Un nouveau cours pratique sur Adobe Acrobat version 6.0 est proposé à l'ensemble du personnel par le service de l'Enseignement Technique, pour répondre aux besoins de formation des utilisateurs des documents PDF. La première session aura lieu le 1er mars 2005. Objectifs : Maîtriser les différentes fonctions d'Adobe Acrobat 6.0. Programme : Présentation d'Adobe Acrobat 6.0. Création de fichiers PDF depuis Microsoft Office et d'autres applications. Création de fichiers Postscript. Modification de fichiers PDF, enregistrement et exportation. Protection par mot de passe et par signature numérique. Navigation dans les documents : interactivité, vignettes et pages, signets, liens, articles, affichage et ouverture des PDF, recherche. Travail en commun: Ajout de commentaires, révision par messagerie électronique Dur&e...

  11. Number 13 / Part I. Music. 3. Mad Scenes: A Warning against Overwhelming Passions

    Directory of Open Access Journals (Sweden)

    Marisi Rossella

    2017-03-01

    Full Text Available This study focuses on mad scenes in poetry and musical theatre, stressing that, according to Aristotle’s theory on catharsis and the Affektenlehre, they had a pedagogical role on the audience. Some mad scenes by J.S. Bach, Handel and Mozart are briefly analyzed, highlighting their most relevant textual and musical characteristics.

  12. Designing and recasting LHC analyses with MadAnalysis 5

    CERN Document Server

    Conte, Eric; Fuks, Benjamin; Wymant, Chris

    2014-01-01

    We present an extension of the expert mode of the MadAnalysis 5 program dedicated to the design or reinterpretation of high-energy physics collider analyses. We detail the predefined classes, functions and methods available to the user and emphasize the most recent developments. The latter include the possible definition of multiple sub-analyses and a novel user-friendly treatment for the selection criteria. We illustrate this approach by two concrete examples: a CMS search for supersymmetric partners of the top quark and a phenomenological analysis targeting hadronically decaying monotop systems.

  13. Environmental analysis report for the proposed development of a wind turbine array near the town of Thetford Mines and the municipalities of Saint-Jean-de-Brebeuf and Kinnear's Mills by Energie Eolienne Des Moulins S.E.C

    International Nuclear Information System (INIS)

    Dupont, C.; Theberge, M.C.

    2010-01-01

    Energie Eolienne Des Moulins S.E.C. has responded to Hydro-Quebec's call for tenders to construct a wind turbine array in the Chaudiere Appalache area, north of Thetford Mines to meet the future energy needs of the region. This document described the reasons for the project and provided a general description of the project. The company will install 78 wind turbines, of which 75 are 2 MW and 3 are 2.3 MW for a total capacity of 156.9 MW. This project requires a certificate of authorization from the provincial government and must undergo an environmental assessment. As part of the process, public inquiries were held in September and October 2009 to consult with stakeholders, project proponents and those opposed to the project. The main challenges facing the project include concerns by local residents regarding the local economy, visual aesthetics of the project, noise pollution, and hazards for birds and bats. This document also covered other considerations, such as drinking water sources; public security and emergency procedures; telecommunications; electromagnetic interference; shadow effect; eco-tourism; waste management; dust and particulates; forest management; endangered plant species; soil management; wetlands; surface waters; aquatic ecosystems; and deer. Upon review of all these considerations, a follow-up committee at the Quebec Ministry of Sustainable Development, Environment and Parks decided that the project is justifiable and acceptable from an environmental point of view and has recommended that the project proceed. 47 refs., 3 tabs., 3 figs., 4 appendices.

  14. Status of MAD (version 8.5) and future plans

    International Nuclear Information System (INIS)

    Iselin, F.C.

    1993-01-01

    The MAD computer code project was started in 1981 at the European Organization for Nuclear Research (CERN) to provide a flexible framework for particle optical computations. From the beginning various features were considered important. Open-ended and modular design of the program would allow easy addition of new features. Format-free input language would facilitate data preparation. Later the requirement was added that the language should be understood by a variety of other programs. When moving data to other programs this would avoid extensive translations of the data with the corresponding danger of making errors. The internal data structure would describe the machine in a flexible manner and access to this structure should be simple. The program should be easy to maintain. Canonical variables should be used throughout the computations. All these features should not hamper the computational efficiency. This article describes the features of the MAD code. This is followed by two sections giving a general description of the ''standard input language'' and extensions to this language. Finally the data structures introduced and future plans are summarized. (Author)

  15. Involvement of CNOT3 in mitotic progression through inhibition of MAD1 expression

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, Akinori [Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639 (Japan); Kikuguchi, Chisato [Cell Signal Unit, Okinawa Institute of Science and Technology, Kunigami, Okinawa 904-0412 (Japan); Morita, Masahiro; Shimodaira, Tetsuhiro; Tokai-Nishizumi, Noriko; Yokoyama, Kazumasa; Ohsugi, Miho; Suzuki, Toru [Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639 (Japan); Yamamoto, Tadashi, E-mail: tyamamot@ims.u-tokyo.ac.jp [Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639 (Japan); Cell Signal Unit, Okinawa Institute of Science and Technology, Kunigami, Okinawa 904-0412 (Japan)

    2012-03-09

    Highlights: Black-Right-Pointing-Pointer CNOT3 depletion increases the mitotic index. Black-Right-Pointing-Pointer CNOT3 inhibits the expression of MAD1. Black-Right-Pointing-Pointer CNOT3 destabilizes the MAD1 mRNA. Black-Right-Pointing-Pointer MAD1 knockdown attenuates the CNOT3 depletion-induced mitotic arrest. -- Abstract: The stability of mRNA influences the dynamics of gene expression. The CCR4-NOT complex, the major deadenylase in mammalian cells, shortens the mRNA poly(A) tail and contributes to the destabilization of mRNAs. The CCR4-NOT complex plays pivotal roles in various physiological functions, including cell proliferation, apoptosis, and metabolism. Here, we show that CNOT3, a subunit of the CCR4-NOT complex, is involved in the regulation of the spindle assembly checkpoint, suggesting that the CCR4-NOT complex also plays a part in the regulation of mitosis. CNOT3 depletion increases the population of mitotic-arrested cells and specifically increases the expression of MAD1 mRNA and its protein product that plays a part in the spindle assembly checkpoint. We showed that CNOT3 depletion stabilizes the MAD1 mRNA, and that MAD1 knockdown attenuates the CNOT3 depletion-induced increase of the mitotic index. Basing on these observations, we propose that CNOT3 is involved in the regulation of the spindle assembly checkpoint through its ability to regulate the stability of MAD1 mRNA.

  16. Involvement of CNOT3 in mitotic progression through inhibition of MAD1 expression

    International Nuclear Information System (INIS)

    Takahashi, Akinori; Kikuguchi, Chisato; Morita, Masahiro; Shimodaira, Tetsuhiro; Tokai-Nishizumi, Noriko; Yokoyama, Kazumasa; Ohsugi, Miho; Suzuki, Toru; Yamamoto, Tadashi

    2012-01-01

    Highlights: ► CNOT3 depletion increases the mitotic index. ► CNOT3 inhibits the expression of MAD1. ► CNOT3 destabilizes the MAD1 mRNA. ► MAD1 knockdown attenuates the CNOT3 depletion-induced mitotic arrest. -- Abstract: The stability of mRNA influences the dynamics of gene expression. The CCR4–NOT complex, the major deadenylase in mammalian cells, shortens the mRNA poly(A) tail and contributes to the destabilization of mRNAs. The CCR4–NOT complex plays pivotal roles in various physiological functions, including cell proliferation, apoptosis, and metabolism. Here, we show that CNOT3, a subunit of the CCR4–NOT complex, is involved in the regulation of the spindle assembly checkpoint, suggesting that the CCR4–NOT complex also plays a part in the regulation of mitosis. CNOT3 depletion increases the population of mitotic-arrested cells and specifically increases the expression of MAD1 mRNA and its protein product that plays a part in the spindle assembly checkpoint. We showed that CNOT3 depletion stabilizes the MAD1 mRNA, and that MAD1 knockdown attenuates the CNOT3 depletion-induced increase of the mitotic index. Basing on these observations, we propose that CNOT3 is involved in the regulation of the spindle assembly checkpoint through its ability to regulate the stability of MAD1 mRNA.

  17. Le maschere senza volto. Gli eroi “tragici” del nouveau roman

    Directory of Open Access Journals (Sweden)

    Andrea Chiurato

    2017-11-01

    Full Text Available Tra i vari movimenti sperimentali affermatisi nel corso del secondo Novecento il nouveau roman offre un’occasione quanto mai preziosa a chi volesse riconsiderare il mutevole valore e le innumerevoli funzioni attribuite al “tragico” alle soglie dell’era postmoderna. Posta al centro del dibattito critico da Alain Robbe-Grillet, la riflessione sull’ambiguo statuto di questo peculiare genere ha d’altronde rappresentato un momento cruciale nella definizione dell’identità dell’école du regard e del suo peculiare rapporto con la tradizione del canone occidentale. Robbe-Grillet, dal canto suo, pur ispirandosi alla vicenda di Edipo nella sua opera d’esordio, non esiterà in seguito a condannare la tragedia come ingannevole forma di compromesso tra l’uomo e le choses e a rifiutare, insieme a essa, la “metafisica della presenza” di cui sarebbe espressione. Altri nouveaux romanciers – tra cui Michel Butor – preferiranno invece sfruttarne le potenzialità in maniera inedita, ritenendola uno sfondo mitopoietico ideale su cui far emergere i tratti essenziali di una condizione esistenziale all’insegna del crollo delle grandi narrazioni. Al di là delle diverse intenzioni, la rivisitazione della “forma” in sé (in chiave parodica o attualizzante ha di conseguenza svolto un ruolo cruciale sia nella decostruzione del “personaggio-uomo”, sia nella contestazione delle cosiddette “nozioni scadute” tanto indigeste a questa eterogenea collection d’écrivains. Da Les gommes (1953 a L’emploi du temps (1956, per arrivare sino a Sphinx en chapeau (1984, si potrebbero menzionare numerosi esempi a tal riguardo, segno di una fascinazione costante, ma non per questo meno conflittuale, destinata a esercitare una profonda influenza su alcuni dei maggiori dei successi editoriali dello sperimentalismo francese. Un’influenza di cui oggi, ormai esauritisi gli accesi toni dello scandalo e della provocazione che accompagnarono l

  18. The horror of madness in Estrella distante and Nocturno de Chile

    Directory of Open Access Journals (Sweden)

    Bernardo Rocco

    2017-03-01

    Full Text Available The article examines the thematic dimension of madness present in the novels Estrella distante and Nocturno de Chile by Roberto Bolaño in order to determine the various ways by which the narrator subjectivity develops a critical consciousness of madness from the traumatic experience of the Chilean dictatorship. Also, this dimension evidences the articulation of a language of madness as literary aesthetics of artistic experience of limits: the horror. Accordingly, a preliminary analysis of contemporary history as a meeting place between violent media versus artistic media that account for the chiaroscuro of Latin American modernity is offered.

  19. GENDERED DOLLARS: Pin Money, Mad Money, and Changing Notions of a Woman’s Proper Place

    Directory of Open Access Journals (Sweden)

    Janice Traflet

    2008-01-01

    Full Text Available This essay examines the evolution in the meaning and usage of two types of special currencies: pin money and mad money. At the start of the twentieth century, both currencies were considered a woman’s money. By the end of the century, however, both pin money and mad money had lost a large measure of their original gendered connotations. By situating the evolving meanings of these currencies alongside concepts of domesticity, virtuous womanhood, and a woman’s proper place, this essay strives to illuminate the rise and fall of pin money and mad money as uniquely “women’s dollars." 

  20. Mad Men’s Deceptive (Critique Of Creativity

    Directory of Open Access Journals (Sweden)

    Julie Robert

    2012-09-01

    Full Text Available This article analyses Mad Men’s relationship to creativity. Considering popular, industry-specific and scholarly understandings, it uses close readings of the show and its narratological techniques to demonstrate how these potentially contradictory concepts and practices of creativity overlap in the show’s fourth season. The points at which these understandings collide become sources of tension between characters and are marked by narrative gaps that conceal deceptive creativity. The conflicts centre on three primary debates: a the role of alcohol in the creative process, b industry-specific norms of creativity, and c the popular perception that creativity is about expression. Consequently, this article approaches questions about creativity using the show’s own partially elided debates and undermines widely-held romantic beliefs about the creative ‘type’ and the what exactly it means to sell creativity in a corporate setting.

  1. Sanctified madness: the God-intoxicated saints of Bengal.

    Science.gov (United States)

    Morinis, A

    1985-01-01

    The saintly madman is a familiar character in South Asia. To outer appearances he is no different from a lunatic, but the mad saint comes to be revered because his idiocy is popularly believed to arise from a different cause than ordinary madness. The common psychopath neglects social conventions because his consciousness is dimmed by incapacity; the saintly madman also breaches convention, but does so because his heightened consciousness has liberated him from the bonds of convention that entrap ordinary people. In the terms of Hinduism, he has tasted the divine nectar of God-realization and has returned to the human realm intoxicated by the experience. In this paper two popular God intoxicated saints of Bengal are discussed. The question is posed whether 'God intoxication' can be considered a culture-bound syndrome of Bengal. The concept of 'culture bound syndrome' is found to be too narrow to encompass the most significant issues to arise from reflection on the characteristics of the God intoxicated. These larger issues have to do with the relationship between cultural practices and models and mental states (whether deviant, as implied by the term 'syndrome' although deviance does not always carry the negative connotation implicit in 'syndrome', or normal). It is suggested that all cultures culture a limited range of mental states and thus the questions posed by the notion of culture bound syndromes are subsumed by larger questions about the relationship of all mind-states to the socio-cultural environment which conditions them. The conclusion is that God intoxication is indeed a uniquely Bengali mental condition, with variants throughout South Asia and kinship to other mystical states, but that the concept of 'syndrome' is not useful.

  2. Emotional and deliberative reactions to a public crisis: Mad Cow disease in France.

    Science.gov (United States)

    Sinaceur, Marwan; Heath, Chip; Cole, Steve

    2005-03-01

    Although most theories of choice are cognitive, recent research has emphasized the role of emotions. We used a novel context--the Mad Cow crisis in France--to investigate how emotions alter choice even when consequences are held constant. A field study showed that individuals reduced beef consumption in months after many newspaper articles featured the emotional label "Mad Cow," but beef consumption was unaffected after articles featured scientific labels for the same disease. The reverse pattern held for the disease-related actions of a government bureaucracy. A lab study showed that the Mad Cow label induces people to make choices based solely on emotional reactions, whereas scientific labels induce people to consider their own probability judgments. Although the Mad Cow label produces less rational behavior than scientific labels, it is two to four times more common in the environment.

  3. Changes in ethylene signaling and MADS box gene expression are associated with banana finger drop.

    Science.gov (United States)

    Hubert, O; Piral, G; Galas, C; Baurens, F-C; Mbéguié-A-Mbéguié, D

    2014-06-01

    Banana finger drop was examined in ripening banana harvested at immature (iMG), early (eMG) and late mature green (lMG) stages, with contrasting ripening rates and ethylene sensitivities. Concomitantly, 11 ethylene signal transduction components (ESTC) and 6 MADS box gene expressions were comparatively studied in median (control zone, CZ) and pedicel rupture (drop zone DZ) areas in peel tissue. iMG fruit did not ripen or develop finger drop while eMG and lMG fruits displayed a similar finger drop pattern. Several ESTC and MADS box gene mRNAs were differentially induced in DZ and CZ and sequentially in eMG and lMG fruits. MaESR2, 3 and MaEIL1, MaMADS2 and MaMADS5 had a higher mRNA level in eMG and acted earlier, whereas MaERS1, MaCTR1, MaEIL3/AB266319, MaEIL4/AB266320 and MaEIL5/AB266321, MaMADS4 and to a lesser extent MaMADS2 and 5 acted later in lMG. In this fruit, MaERS1 and 3, MaCTR1, MaEIL3, 4 and MaEIL5/AB266321, and MaMADS4 were enhanced by finger drop, suggesting their specific involvement in this process. MaEIL1, MaMADS1 and 3, induced at comparable levels in DZ and CZ, are probably related to the overall fruit ripening process. These findings led us to consider that developmental cues are the predominant finger drop regulation factor. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  4. Materials and technologies in Art Nouveau architecture: Facade decoration cases in Italy, Portugal and Poland for a consistent restoration

    Directory of Open Access Journals (Sweden)

    Sandrolini, F.

    2011-12-01

    Full Text Available The results of a diagnostic survey on the materials of representative Art Nouveau buildings in Italy, Portugal and Poland are here presented and compared, as a contribution to their understanding and, hence, to support compatible restoration. In particular, the facade decorations were investigated for the appraisal of their materials and technologies, often neglected in current maintenance/restoration works and so cancelled, leading to a severe loss in architectural image. The ongoing diagnostic campaign, in collaboration among different universities, is aimed to set up a database on materials and technologies of Art Nouveau facade decorations at a European scale, as a technical-scientific background for the highlighting of preservation guidelines.

    En este trabajo se presentan los resultados de un estudio de diagnóstico sobre materiales representativos de edificios del periodo del Modernismo en Italia, Portugal y Polonia. Con la comparación de estos resultados se pretende contribuir a incrementar el conocimiento de los materiales usados en este patrimonio, que permita realizar más eficazmente las futuras intervenciones de restauración. En particular, se analizan las decoraciones de las fachadas, pasando por el reconocimiento de sus materiales constituyentes y de las tecnologías usadas, que muchas veces no son adecuadamente estudiados en intervenciones de mantenimiento y/o restauración, provocando graves pérdidas en su imagen y lenguaje arquitectónico original. Con la campaña de trabajos de diagnóstico, en colaboración con varias universidades, se pretende crear una base de datos sobre materiales y tecnologías usados en las decoraciones de fachada en el periodo del Modernismo a una escala europea. El material podrá constituirse en una herramienta técnico-científica de soporte al desarrollo de directrices y recomendaciones para la preservación de este patrimonio.

  5. A balance of Mad and Myc expression dictates larval cell apoptosis and adult stem cell development during Xenopus intestinal metamorphosis.

    Science.gov (United States)

    Okada, Morihiro; Miller, Thomas C; Wen, Luan; Shi, Yun-Bo

    2017-05-11

    The Myc/Mad/Max network has long been shown to be an important factor in regulating cell proliferation, death and differentiation in diverse cell types. In general, Myc-Max heterodimers activate target gene expression to promote cell proliferation, although excess of c-Myc can also induce apoptosis. In contrast, Mad competes against Myc to form Mad-Max heterodimers that bind to the same target genes to repress their expression and promote differentiation. The role of the Myc/Mad/Max network during vertebrate development, especially, the so-called postembryonic development, a period around birth in mammals, is unclear. Using thyroid hormone (T3)-dependent Xenopus metamorphosis as a model, we show here that Mad1 is induced by T3 in the intestine during metamorphosis when larval epithelial cell death and adult epithelial stem cell development take place. More importantly, we demonstrate that Mad1 is expressed in the larval cells undergoing apoptosis, whereas c-Myc is expressed in the proliferating adult stem cells during intestinal metamorphosis, suggesting that Mad1 may have a role in cell death during development. By using transcription activator-like effector nuclease-mediated gene-editing technology, we have generated Mad1 knockout Xenopus animals. This has revealed that Mad1 is not essential for embryogenesis or metamorphosis. On the other hand, consistent with its spatiotemporal expression profile, Mad1 knockout leads to reduced larval epithelial apoptosis but surprisingly also results in increased adult stem cell proliferation. These findings not only reveal a novel role of Mad1 in regulating developmental cell death but also suggest that a balance of Mad and Myc controls cell fate determination during adult organ development.

  6. The encounter with God in myth and madness.

    Science.gov (United States)

    Doerr, Otto; Velásquez, Oscar

    2007-07-03

    It is well known how often psychiatric patients report religious experiences. These are especially frequent in schizophrenic and epileptic patients as the subject of their delusions. The question we pose is: are there differences between this kind of religious experiences and those we find in religious texts or in the mythological tradition? An overview on famous mythological narratives, such as The Aeneid, allows us to establish that the divinities become recognizable to the human being at the moment of their departure. Thus, Aeneas does not recognise his mother, Venus, when she appears to him in the middle of the forest at the coast of Africa. A dialogue between the two takes place, and only at the end of the encounter, when she is going away and already with her back to Aeneas, she shows her son the signs of her divinity: the rose-flush emanating from her neck, her hair perfume and the majesty of her gait. Something analogous can be observed in the encounter of Moses with Yahweh on Mount Sinai. Moses asks God: "Show me your glory, I beg you". And God replies, among other things: "you shall see the back of me, but my face is not to be seen". In the same sense, the Emmaus disciples do not recognise Jesus till the moment of his disappearance ("but he had vanished from their sight"), and Saul of Tars falls off his horse just in the moment when he feels the divine presence. In short, the direct encounter with the divinity seems not to occur in the realm of myth or in religious tradition. The realm of madness is exactly the opposite. Our research on religious experiences in schizophrenic and epileptic patients leads us to conclude that God appears to them face to face, and the patient describes God the father, Jesus or the Virgin Mary in intimate detail, always in an everyday setting. So, the divinity is seen in the garden, or in the bedroom, or maybe above the wardrobe, without any of its majesty. The nearness to God also tends to be so extreme that even an

  7. Mad, terroir og tv: Smag på Danmark!

    Directory of Open Access Journals (Sweden)

    Dorthe Refslund Christensen

    2008-09-01

    Full Text Available Mad fylder mere i medierne, men hvordan underholder fx et madprogram på tv? Med afsæt i de 13 afsnit af Claus Meyer-serien Smag på Danmark! undersøger vi, hvordan serien er konstrueret og fortalt. Især ser vi på, hvilken rolle de 13 forskellige steder, som serien foregår på, har. Vi diskuterer begreber som terroir og mytologisering. Serien etablerer dobbeltheder og relationer, og i tråd med dette forlenes sted som terroir både med al og med ingen betydning. Mad knyttes som et tegn, med Barthes in mente, til stedet, men på en måde, der leverer rum for seerens eget forestillingsarbejde. Serien demonstrerer for seerne, hvordan smagsdomme kan foregå med Meyer som seerens stedfortræder i et ferie- og fritidsunivers. Den nydelse, som serien konstant etablerer, demonstrerer og anticiperer, kan seeren deltage i med sit eget fantasiarbejde: Det er god underholdning, fordi så meget er overladt til seernes forestillingsarbejde. Food, Terroir, and Television: Taste Denmark! Food has become more dominant in the media landscape, but how does a food programme on television entertain us? We analyse how the 13 episodes of the Claus Meyer series Smag på Danmark (Taste Denmark!are constructed and narrated. We pay particular attention to the different locations of the episodes and discuss the terms terroir and mythologization. The series establishes ambiguities and relations, and in this connection the location understood as terroir means everything – and at the same time means nothing at all. With reference to Barthes, the series links food as a sign to location, but in such a way that room is left for the viewer’s own imagination. The series demonstrates to the viewers how judgements of taste can be made in a time of leisure and a universe of holidays, with Meyer acting as the viewer’s proxy. The series is constantly establishing, demonstrating and anticipating a pleasure in which the viewer can participate in his or her own imagination

  8. The encounter with God in myth and madness

    Directory of Open Access Journals (Sweden)

    Doerr Otto

    2007-07-01

    Full Text Available Abstract Background It is well known how often psychiatric patients report religious experiences. These are especially frequent in schizophrenic and epileptic patients as the subject of their delusions. The question we pose is: are there differences between this kind of religious experiences and those we find in religious texts or in the mythological tradition? Results An overview on famous mythological narratives, such as The Aeneid, allows us to establish that the divinities become recognizable to the human being at the moment of their departure. Thus, Aeneas does not recognise his mother, Venus, when she appears to him in the middle of the forest at the coast of Africa. A dialogue between the two takes place, and only at the end of the encounter, when she is going away and already with her back to Aeneas, she shows her son the signs of her divinity: the rose-flush emanating from her neck, her hair perfume and the majesty of her gait. Something analogous can be observed in the encounter of Moses with Yahweh on Mount Sinai. Moses asks God: "Show me your glory, I beg you". And God replies, among other things: "you shall see the back of me, but my face is not to be seen". In the same sense, the Emmaus disciples do not recognise Jesus till the moment of his disappearance ("but he had vanished from their sight", and Saul of Tars falls off his horse just in the moment when he feels the divine presence. In short, the direct encounter with the divinity seems not to occur in the realm of myth or in religious tradition. The realm of madness is exactly the opposite. Our research on religious experiences in schizophrenic and epileptic patients leads us to conclude that God appears to them face to face, and the patient describes God the father, Jesus or the Virgin Mary in intimate detail, always in an everyday setting. So, the divinity is seen in the garden, or in the bedroom, or maybe above the wardrobe, without any of its majesty. The nearness to God

  9. User's guide to program MAD: a computer program for the organization and manipulation of magnetic tape directories

    International Nuclear Information System (INIS)

    Gray, W.H.

    1979-05-01

    MAD is a computer program for the organization and manipulation of the information contained in magnetic tape directories. Program MAD creates, updates, and interrogates a set of four random access files collectively called the MAD unified data base. Although program MAD was originally intended as an information compression mechanism, it has evolved into an organization system with the added feature of an approximately 60% reduction in the space required to store the data. This program is easy to use, relatively fast, efficient in its use of disk space, and available to all users of the Fusion Energy Division DECsystem-10

  10. Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast

    International Nuclear Information System (INIS)

    Shimada, Midori; Yamamoto, Ayumu; Murakami-Tonami, Yuko; Nakanishi, Makoto; Yoshida, Takashi; Aiba, Hirofumi; Murakami, Hiroshi

    2009-01-01

    The spindle checkpoint is a surveillance mechanism that ensures the fidelity of chromosome segregation in mitosis. Here we show that fission yeast casein kinase II (CK2) is required for this checkpoint function. In the CK2 mutants mitosis occurs in the presence of a spindle defect, and the spindle checkpoint protein Mad2p fails to localize to unattached kinetochores. The CK2 mutants are sensitive to the microtubule depolymerising drug thiabendazole, which is counteracted by ectopic expression of mad2 + . The level of Mad2p is low in the CK2 mutants. These results suggest that CK2 has a role in the spindle checkpoint by regulating Mad2p.

  11. Restoring Madness to History in J.M. Coetzee’s In the Heart of the Country

    Directory of Open Access Journals (Sweden)

    William Collins

    2015-01-01

    Full Text Available This article interrogates the curious dismissal of madness from the critical landscape surrounding J. M. Coetzee’s In the Heart of the Country, and makes suggestions concerning how madness works in the novel and why—given certain critical and historical pressures—it has been persistently sidelined. An analysis of the novel in light of Coetzee’s scholarship on Samuel Beckett suggests that Magda’s discourse, like those of many Beckettian narrators, follows patterns of affirmation and auto-negation, constituting a fiction of what Coetzee calls “net zero.” In particular, Magda extends this pattern to the taking on and casting off of identities, perhaps in the style of the hermit crab she puts forward as an image of herself. An intertextual examination of the semantic and rhetorical range of madness as it appears in Coetzee’s other fiction and scholarship reveals that madness, for Coetzee, consistently denotes: on the one hand, a contagious force moving throughout a social body, and on the other hand, the labor of writing under the threat of illegibility—a threat conditioned in large part by the madness of the social body. By infecting the writer who might record its workings in history and thereby inhibiting or distorting that record, madness likewise appears in historical record as “net zero.” Thus, rather than simply being mad, Magda’s relationship with madness is emblematic of the (disappearance of madness in and from history.

  12. Madness in blaise cendrars' novels: moravagine and company.

    Science.gov (United States)

    Tatu, Laurent; Bogousslavsky, Julien

    2013-01-01

    The literary work of Blaise Cendrars (1887-1961), né Frédéric Sauser, one of the major French-speaking authors of the 20th century, is imbued with references to neuropsychiatry. This theme is a constant presence in his writing as a result of his involvement of the First World War and his personal experiences, which were punctuated with neurologic and psychiatric events. Cendrars' own particular ideas on the genesis of mental disorders went against the more traditional views on psychiatry. He remained skeptical about hysteria and did not subscribe to psychoanalysis. His ideas were enriched by his experience with the war-related neuropsychiatric problems developed by soldiers. He thus proposed the notion of 'pathological fear' surrounding these disorders. There are a number of characters suffering from 'borderline' mental disorders in Cendrars' work, including two shocking, mad murderers, Moravagine and Fébronio. The character Moravagine, a neurology patient suffering from a brain tumor, enabled Cendrars to delve into the grey areas that can exist between neurologic and psychiatric diseases. Fébronio, a real psychotic, enabled Cendrars to explore ethnopsychiatry. Copyright © 2013 S. Karger AG, Basel.

  13. Agave tequilana MADS genes show novel expression patterns in meristems, developing bulbils and floral organs.

    Science.gov (United States)

    Delgado Sandoval, Silvia del Carmen; Abraham Juárez, María Jazmín; Simpson, June

    2012-03-01

    Agave tequilana is a monocarpic perennial species that flowers after 5-8 years of vegetative growth signaling the end of the plant's life cycle. When fertilization is unsuccessful, vegetative bulbils are induced on the umbels of the inflorescence near the bracteoles from newly formed meristems. Although the regulation of inflorescence and flower development has been described in detail for monocarpic annuals and polycarpic species, little is known at the molecular level for these processes in monocarpic perennials, and few studies have been carried out on bulbils. Histological samples revealed the early induction of umbel meristems soon after the initiation of the vegetative to inflorescence transition in A. tequilana. To identify candidate genes involved in the regulation of floral induction, a search for MADS-box transcription factor ESTs was conducted using an A. tequilana transcriptome database. Seven different MIKC MADS genes classified into 6 different types were identified based on previously characterized A. thaliana and O. sativa MADS genes and sequences from non-grass monocotyledons. Quantitative real-time PCR analysis of the seven candidate MADS genes in vegetative, inflorescence, bulbil and floral tissues uncovered novel patterns of expression for some of the genes in comparison with orthologous genes characterized in other species. In situ hybridization studies using two different genes showed expression in specific tissues of vegetative meristems and floral buds. Distinct MADS gene regulatory patterns in A. tequilana may be related to the specific reproductive strategies employed by this species.

  14. Derrida, Foucault and “Madness, the Absence of an Œuvre”

    Directory of Open Access Journals (Sweden)

    Seferin James

    Full Text Available This article argues that Foucault's 1964 paper “La folie, l'absence d'œuvre” ought to be understood as a response to Derrida's 1963 paper “Cogito et histoire de la folie”. I clarify the chronology of the exchange between these two thinkers and follow commentators Bennington and Flynn in emphasising themes other than the status of madness in Descartes. I undertake a thematic investigation of Foucault's 1961 characterisation of madness as the absence of an œuvre and the role of this characterisation in Derrida's 1963 paper. Then I turn to an investigation of Foucault's substantial change in position on these key themes with his 1964 paper. I argue that Foucault seeks to minimise the initial importance he attributed to his characterisation of madness as the absence of an œuvre, altering his understanding of the relation between madness and language as well as shifting the event that silences madness from Descartes to Freud. Derrida's reconsideration of Foucault's Folie et déraison in 1991 treats Freud as the new locus of the exchange. This is an implicit recognition by Derrida of Foucault's “La folie, l'absence d'œuvre” and confirmation of its place within the exchange.

  15. Hydraulic analysis, Mad River at State Highway 41, Springfield, Ohio

    Science.gov (United States)

    Mayo, Ronald I.

    1977-01-01

    A hydraulic analysis of the lad River in a reach at Springfield, Ohio was made to determine the effects of relocating State Highway 41 in 1S76. The main channel was cleaned by dredging in the vicinity cf the new highway bridge and at the Detroit, Toledo and Ironton Railway bridge upstream. The new highway was placed on a high fill with relief structures for flood plain drainage consisting of a 12-foot corrugated metal pipe culvert and a bridge opening to accommodate the Detroit, Toledo and Ironton Railway and a property access road. The effect of the new highway embankment on drainage from the flood plain was requested. Also requested was the effect that might be expected on the elevation of flood waters above the new highway embankment if the access road through the new highway embankment were raised.The study indicates that the improvement in the capacity of the main channel to carry water was such that, up to a discharge equivalent to a 25-year frequency flood, the water-surface elevation in the reach upstream from the Detroit, Toledo and Ironton Railway bridge would be about 0.6 foot lower than under conditions prior to the construction on State Highway 41. Diversion through the Mad River left bank levee break above the Detroit, Toledo and Ironton Railway bridge to the flood Flain would be decreased about one-half in terms of rate of discharge in cubic feet per second. The maximum difference in elevation cf the flood water between the upstream and downstream side of the new State Highway 41 embankment would be about 0.2 foot, with an additional 0.4 foot to be expected if the access road were raised 1.5 feet.

  16. Multivariate Alteration Detection (MAD) and MAF Postprocessing in Multispectral, Bitemporal Image Data: New Approaches to Change Detection Studies

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg; Conradsen, Knut; Simpson, James J.

    1998-01-01

    type analyses of simple difference images. Case studies with AHVRR and Landsat MSS data using simple linear stretching and masking of the change images show the usefulness of the new MAD and MAF/MAD change detection schemes. Ground truth observations confirm the detected changes. A simple simulation...

  17. Characterization of a Smad motif similar to Drosophila mad in the mouse Msx 1 promoter.

    Science.gov (United States)

    Alvarez Martinez, Cristina E; Binato, Renata; Gonzalez, Sayonara; Pereira, Monica; Robert, Benoit; Abdelhay, Eliana

    2002-03-01

    Mouse Msx 1 gene, orthologous of the Drosophila msh, is involved in several developmental processes. BMP family members are major proteins in the regulation of Msx 1 expression. BMP signaling activates Smad 1/5/8 proteins, which associate to Smad 4 before translocating to the nucleus. Analysis of Msx 1 promoter revealed the presence of three elements similar to the consensus established for Mad, the Smad 1 Drosophila counterpart. Notably, such an element was identified in an enhancer important for Msx 1 regulation. Gel shift analysis demonstrated that proteins from 13.5 dpc embryo associate to this enhancer. Remarkably, supershift assays showed that Smad proteins are present in the complex. Purified Smad 1 and 4 also bind to this fragment. We demonstrate that functional binding sites in this enhancer are confined to the Mad motif and flanking region. Our data suggest that this Mad motif may be functional in response to BMP signaling. ©2002 Elsevier Science (USA).

  18. madSTORM: a superresolution technique for large-scale multiplexing at single-molecule accuracy

    Science.gov (United States)

    Yi, Jason; Manna, Asit; Barr, Valarie A.; Hong, Jennifer; Neuman, Keir C.; Samelson, Lawrence E.

    2016-01-01

    Investigation of heterogeneous cellular structures using single-molecule localization microscopy has been limited by poorly defined localization accuracy and inadequate multiplexing capacity. Using fluorescent nanodiamonds as fiducial markers, we define and achieve localization precision required for single-molecule accuracy in dSTORM images. Coupled with this advance, our new multiplexing strategy, madSTORM, allows accurate targeting of multiple molecules using sequential binding and elution of fluorescent antibodies. madSTORM is used on an activated T-cell to localize 25 epitopes, 14 of which are on components of the same multimolecular T-cell receptor complex. We obtain an average localization precision of 2.6 nm, alignment error of 2.0 nm, and molecules within structures. Probing the molecular topology of complex signaling cascades and other heterogeneous networks is feasible with madSTORM. PMID:27708141

  19. Generating QCD amplitudes in the color-flow basis with MadGraph

    International Nuclear Information System (INIS)

    Hagiwara, Kaoru; Takaesu, Yoshitaro

    2011-01-01

    We propose to make use of the off-shell recursive relations with the color-flow decomposition in the calculation of QCD amplitudes on MadGraph. We introduce colored quarks and their interactions with nine gluons in the color-flow basis plus an Abelian gluon on MadGraph, such that it generates helicity amplitudes in the color-flow basis with off-shell recursive formulae for multi-gluon sub-amplitudes. We demonstrate calculations of up to 5-jet processes such as gg→5g, u anti u→5g and uu→uuggg. Although our demonstration is limited, it paves the way to evaluate amplitudes with more quark lines and gluons with MadGraph. (orig.)

  20. The Regularized Iteratively Reweighted MAD Method for Change Detection in Multi- and Hyperspectral Data

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg

    2007-01-01

    This paper describes new extensions to the previously published multivariate alteration detection (MAD) method for change detection in bi-temporal, multi- and hypervariate data such as remote sensing imagery. Much like boosting methods often applied in data mining work, the iteratively reweighted...... to observations that show little change, i.e., for which the sum of squared, standardized MAD variates is small, and small weights are assigned to observations for which the sum is large. Like the original MAD method, the iterative extension is invariant to linear (affine) transformations of the original...... an agricultural region in Kenya, and hyperspectral airborne HyMap data from a small rural area in southeastern Germany are given. The latter case demonstrates the need for regularization....

  1. Menti opache. Mad Men e la rappresentazione dell’interiorità nelle serie TV

    Directory of Open Access Journals (Sweden)

    Gianluigi Rossini

    2014-06-01

    Full Text Available One of the most visible features of Mad Men is the opposition between the lavish visual surface and the lack of depth in the description of characters. It's very difficult to empathise with Don Draper and many other Mad Men's characters, because their psychology often seems completely inaccessible or unexpressed, contrary to what happens in most contemporary TV series. The aim of this essay is to show how and why the authorial agency conveys an 'opacity effect' that clouds the spectator's understanding of the thoughts and feelings of the characters. In doing this, I will place Mad Men inside a tradition of TV series centred on the psychology and emotions of characters. The analysis will be carried out within two theoretical frameworks: James Phelan's rethorical theory of narrative and Celestino Deleyto's model of film narrative.

  2. A "His Story" of Insanity: Madness and Masculinity in Twentieth-Century American Literature

    OpenAIRE

    Bumeistere, Lilita

    2013-01-01

    This thesis is an interdisciplinary study of the largely neglected relationship between madness and masculinity based on three American literary works written during different periods of the twentieth century. The study utilizes literary, social, and medical research in order to provide a holistic view of madness and masculinity as two social constructs that interact with and are contingent on each other. In Sherwood Anderson’s “Hands,” Ken Kesey’s One Flew Over the Cuckoo’s Nest, and David F...

  3. The secular and the supernatural: madness and psychiatry in the short stories of Muriel Spark.

    Science.gov (United States)

    Beveridge, A W

    2015-01-01

    Edinburgh-born Muriel Spark is one of modern Scotland's greatest writers. Examination of her work reveals that the subjects of madness and psychiatry are recurrent themes in her writing. She herself had a mental breakdown when she was a young woman and she took an interest in the world of psychiatry and psychoanalysis. In her short stories, Spark approaches the subject of madness in a variety of ways: she relates it to the supernatural; to writing fiction; and to religion. She frequently juxtaposes secular and supernatural explanations of mental disturbance. Spark adopts a sceptical and, at times, mocking view of psychiatrists and psychiatric treatment. Both psychoanalysis and pills are seen as problematic.

  4. GENDERED DOLLARS: Pin Money, Mad Money, and Changing Notions of a Woman’s Proper Place

    OpenAIRE

    Janice Traflet

    2008-01-01

    This essay examines the evolution in the meaning and usage of two types of special currencies: pin money and mad money. At the start of the twentieth century, both currencies were considered a woman’s money. By the end of the century, however, both pin money and mad money had lost a large measure of their original gendered connotations. By situating the evolving meanings of these currencies alongside concepts of domesticity, virtuous womanhood, and a woman’s proper place, this essay strives t...

  5. A rare case of Kounis syndrome provoked by mad honey poisoning

    Directory of Open Access Journals (Sweden)

    Yakup Alsancak

    2016-06-01

    Full Text Available Kounis syndrome, resulting in acute coronary syndromes, as a result of allergic or hypersensitivity reaction is triggered by several factors. Vasospasm which is mediated by mediators released after mast cell activation, is the responsible mechanism for comprising of type 2-myocardial infarction. Mad honey containing grayanotoxin is previously shown to be associated with gastrointestinal, neurological and cardiac disorders. In this case report, we presented a Kounis syndrome that has occurred after the mad honey intake and treated successfully, previously not mentioned in the literature.

  6. [Existence, Absence and Power of Madness: A Critical Review of Michel Foucault's Writings on the History and Philosophy of Madness].

    Science.gov (United States)

    Brückner, Burkhart; Iwer, Lukas; Thoma, Samuel

    2017-03-01

    This article discusses Michel Foucault's main writings on "madness and psychiatry" from his early works up to the 1970s. On the one hand, we reconstruct the overall theoretical and methodological development of his positions over the course of the different periods in his oeuvre. On the other hand, we also take a closer look at Foucault's philosophical considerations regarding the subjects of his investigations. After an initial introduction of our conceptual approach, we draw on the most recent research on Foucault to show to what extent the phenomenological description of the topic at hand and the historical-critical perspective that are reflected in his early writings of 1954 (the Introduction to Binswanger's Dream and Existence and Mental Illness and Personality) laid the ground for his later work. Moving on to Foucault's work during the 1960s, we look at the core features and methodological bases of his 1961 classic Folie et déraison (History of Madness). His propositions regarding the "absence of madness" in modernity are conceptualized as an inherently contradictory attempt to liberate the topic under study from the common assumptions at that time. We then situate his 1973/74 lectures on Psychiatric Power in the context of his shift towards analyzing the dynamics of power and highlight the renewed shift of focus in his statements on the "productivity" of madness as an effect of power. Finally, we sum up our critique by taking into account the history of the reception of Foucault's writings and ask about their potential significance for the contemporary philosophy and history of psychiatry.

  7. Conformation-specific anti-Mad2 monoclonal antibodies for the dissection of checkpoint signaling

    DEFF Research Database (Denmark)

    Sedgwick, Garry G; Larsen, Marie Sofie Yoo; Lischetti, Tiziana

    2016-01-01

    The spindle assembly checkpoint (SAC) ensures accurate chromosome segregation during mitosis by delaying the activation of the anaphase-promoting complex/cyclosome (APC/C) in response to unattached kinetochores. The Mad2 protein is essential for a functional checkpoint because it binds directly t...

  8. The contaminated Western Hero and other madness during the Atomic Age

    International Nuclear Information System (INIS)

    Herzog, Rudolph

    2012-01-01

    The book on mad activities during the Atomic Age includes the following topics: The second most hazardous invention in all time; the red bomb; the story on the tactic nuclear war; the contaminated Western hero or how the bomb came to Alaska; swords into plowshares; the apocalypse machine; flying reactors; how safe is safe?; atomic Australia; nuclear medicine on wrong ways; broken arrows.

  9. An Act of Methodology: A Document in Madness--Writing Ophelia

    Science.gov (United States)

    Steinnes, Jenny

    2012-01-01

    This paper is an attempt to stage some questions concerning methodology and education, inspired by Ophelia in Shakespeare's "Hamlet" and by Jacques Derrida's poetic philosophical oeuvres. What are at stake are the long traditions of preferences of sanity over madness, friend over enemy, male over female and of clean, unambiguous univocal language…

  10. Automatic Radiometric Normalization of Multitemporal Satellite Imagery with the Iteratively Re-weighted MAD Transformation

    DEFF Research Database (Denmark)

    Canty, Morton John; Nielsen, Allan Aasbjerg

    2008-01-01

    A recently proposed method for automatic radiometric normalization of multi- and hyper-spectral imagery based on the invariance property of the Multivariate Alteration Detection (MAD) transformation and orthogonal linear regression is extended by using an iterative re-weighting scheme involving no...

  11. MAD about the Large Magellanic Cloud Preparing for the era of Extremely Large Telescopes

    NARCIS (Netherlands)

    Fiorentino, G.; Tolstoy, E.; Diolaiti, E.; Valenti, E.; Cignoni, M.; Mackey, A. D.

    We present J, H, K-s photometry from the the Multi conjugate Adaptive optics Demonstrator (MAD), a visitor instrument at the VLT, of a resolved stellar population in a small crowded field in the bar of the Large Magellanic Cloud near the globular cluster NGC 1928. In a total exposure time of 6, 36

  12. pikelet MADS develo S-box opmen genes nt and m maize

    African Journals Online (AJOL)

    SAM

    ze plant. (B) M e spikelet. Late e floret of female in female ens in the up elet bearing efore, unisex ... e plant MADS members of a ..... and their role in the development and evolution of flowering plants. Mol. .... Classification and phylogeny of.

  13. Eesti parima lühifilmi tegi Madli Lääne

    Index Scriptorium Estoniae

    2007-01-01

    Pimedate Ööde filmifestivali tudengi- ja lühifilmide alafestivali Sleepwalkers parimaks tunnistati Poola tudengi Jan Wagneri lühimängufilm "Porno". Eesti võistluse võitis Madli Lääne dokfilm "Tähelepanu, start!". Parim mängufilm oli Rootsi "Korterikaaslased" (režii Magnus Mork) ja animafilm USA "Erinevad asjaolud"

  14. The Sad, the Mad and the Bad: Co-Existing Discourses of Girlhood

    Science.gov (United States)

    Brown, Marion

    2011-01-01

    Three significant, prevailing and overlapping narratives of teenage girls have dominated North American popular consciousness since the early 1990s: the sad girl, victimized by male privilege and misogyny of adolescence and beyond; the mad grrrls who rejected this vulnerability through music and media; and the bad girls of much current popular…

  15. Proteomics and SSH analyses of ALA-promoted fruit coloration and evidence for the involvement of a MADS-box gene, MdMADS1

    Directory of Open Access Journals (Sweden)

    Xinxin Feng

    2016-11-01

    Full Text Available Skin color is a key quality attribute of fruits and how to improve fruit coloration has long been a major concern. 5-Aminolevulinic acid (ALA, a natural plant growth regulator, can significantly increase anthocyanin accumulation in fruit skin and therefore effectively improve coloration of many fruits, including apple. However, the molecular mechanism how ALA stimulates anthocyanin accumulation in fruit skin remains unknown. Here, we investigated the impact of ALA on apple skin at the protein and mRNA levels. A total of 85 differentially expressed proteins in apple skins between ALA and water treatment (control were identified by complementary gel-based and gel-freeseparation techniques. Most of these differentially expressed proteins were up-regulated by ALA. Function analysis suggested that 87.06% of the ALA-responsive proteins were associated with fruit ripening. To further screen ALA-responsive regulators, we constructed a subtracted cDNA library (tester: ALA treatment; driver: control and obtained 104 differentially expressed unigenes, of which 38 unigenes were indicators for the fruit ripening-related gene. The differentially changed proteins and transcripts did not correspond well at an individual level, but showed similar regulated direction in function at the pathway level. Among the identified fruit ripening-related genes, the expression of MdMADS1, a developmental transcription regulator of fruit ripening, was positively correlated with expression of anthocyanin biosynthetic genes (MdCHS, MdDFR, MdLDOX and MdUFGT in apple skin under ALA treatment. Moreover, overexpression of MdMADS1 enhanced anthocyanin content in transformed apple calli, which was further enhanced by ALA. The anthocyanin content in MdMADS1-silenced calli was less than that in the control with ALA treatment, but higher than that without ALA treatment. These results indicated that MdMADS1 is involved in ALA-induced anthocyanin accumulation. In addition, anthocyanin

  16. Environmental analysis report for the proposed development of a wind turbine array near the town of Thetford Mines and the municipalities of Saint-Jean-de-Brebeuf and Kinnear's Mills by Energie Eolienne Des Moulins S.E.C.; Rapport d'analyse environnementale pour le projet d'amenagement du parc eolien Des Moulins sur le territoire de la ville de Thetford Mines ainsi que des municipalites de Saint-Jean-de-Brebeuf et de Kinnear's Mills par Energie Eolienne Des Moulins S.E.C.

    Energy Technology Data Exchange (ETDEWEB)

    Dupont, C.; Theberge, M.C. [Quebec Ministere du Developpement durable, de l' Environnement et des Parcs, Quebec, PQ (Canada). Direction des evaluations environnementales, Services des projets en milieu terrestre

    2010-10-06

    Energie Eolienne Des Moulins S.E.C. has responded to Hydro-Quebec's call for tenders to construct a wind turbine array in the Chaudiere Appalache area, north of Thetford Mines to meet the future energy needs of the region. This document described the reasons for the project and provided a general description of the project. The company will install 78 wind turbines, of which 75 are 2 MW and 3 are 2.3 MW for a total capacity of 156.9 MW. This project requires a certificate of authorization from the provincial government and must undergo an environmental assessment. As part of the process, public inquiries were held in September and October 2009 to consult with stakeholders, project proponents and those opposed to the project. The main challenges facing the project include concerns by local residents regarding the local economy, visual aesthetics of the project, noise pollution, and hazards for birds and bats. This document also covered other considerations, such as drinking water sources; public security and emergency procedures; telecommunications; electromagnetic interference; shadow effect; eco-tourism; waste management; dust and particulates; forest management; endangered plant species; soil management; wetlands; surface waters; aquatic ecosystems; and deer. Upon review of all these considerations, a follow-up committee at the Quebec Ministry of Sustainable Development, Environment and Parks decided that the project is justifiable and acceptable from an environmental point of view and has recommended that the project proceed. 47 refs., 3 tabs., 3 figs., 4 appendices.

  17. Identification and Characterization of the MADS-Box Genes and Their Contribution to Flower Organ in Carnation (Dianthus caryophyllus L.).

    Science.gov (United States)

    Zhang, Xiaoni; Wang, Qijian; Yang, Shaozong; Lin, Shengnan; Bao, Manzhu; Bendahmane, Mohammed; Wu, Quanshu; Wang, Caiyun; Fu, Xiaopeng

    2018-04-04

    Dianthus is a large genus containing many species with high ornamental economic value. Extensive breeding strategies permitted an exploration of an improvement in the quality of cultivated carnation, particularly in flowers. However, little is known on the molecular mechanisms of flower development in carnation. Here, we report the identification and description of MADS-box genes in carnation ( DcaMADS ) with a focus on those involved in flower development and organ identity determination. In this study, 39 MADS-box genes were identified from the carnation genome and transcriptome by the phylogenetic analysis. These genes were categorized into four subgroups (30 MIKC c , two MIKC*, two Mα, and five Mγ). The MADS-box domain, gene structure, and conserved motif compositions of the carnation MADS genes were analysed. Meanwhile, the expression of DcaMADS genes were significantly different in stems, leaves, and flower buds. Further studies were carried out for exploring the expression of DcaMADS genes in individual flower organs, and some crucial DcaMADS genes correlated with their putative function were validated. Finally, a new expression pattern of DcaMADS genes in flower organs of carnation was provided: sepal (three class E genes and two class A genes), petal (two class B genes, two class E genes, and one SHORT VEGETATIVE PHASE ( SVP )), stamen (two class B genes, two class E genes, and two class C), styles (two class E genes and two class C), and ovary (two class E genes, two class C, one AGAMOUS-LIKE 6 ( AGL6 ), one SEEDSTICK ( STK ), one B sister , one SVP , and one Mα ). This result proposes a model in floral organ identity of carnation and it may be helpful to further explore the molecular mechanism of flower organ identity in carnation.

  18. Identification and Characterization of the MADS-Box Genes and Their Contribution to Flower Organ in Carnation (Dianthus caryophyllus L.

    Directory of Open Access Journals (Sweden)

    Xiaoni Zhang

    2018-04-01

    Full Text Available Dianthus is a large genus containing many species with high ornamental economic value. Extensive breeding strategies permitted an exploration of an improvement in the quality of cultivated carnation, particularly in flowers. However, little is known on the molecular mechanisms of flower development in carnation. Here, we report the identification and description of MADS-box genes in carnation (DcaMADS with a focus on those involved in flower development and organ identity determination. In this study, 39 MADS-box genes were identified from the carnation genome and transcriptome by the phylogenetic analysis. These genes were categorized into four subgroups (30 MIKCc, two MIKC*, two Mα, and five Mγ. The MADS-box domain, gene structure, and conserved motif compositions of the carnation MADS genes were analysed. Meanwhile, the expression of DcaMADS genes were significantly different in stems, leaves, and flower buds. Further studies were carried out for exploring the expression of DcaMADS genes in individual flower organs, and some crucial DcaMADS genes correlated with their putative function were validated. Finally, a new expression pattern of DcaMADS genes in flower organs of carnation was provided: sepal (three class E genes and two class A genes, petal (two class B genes, two class E genes, and one SHORT VEGETATIVE PHASE (SVP, stamen (two class B genes, two class E genes, and two class C, styles (two class E genes and two class C, and ovary (two class E genes, two class C, one AGAMOUS-LIKE 6 (AGL6, one SEEDSTICK (STK, one B sister, one SVP, and one Mα. This result proposes a model in floral organ identity of carnation and it may be helpful to further explore the molecular mechanism of flower organ identity in carnation.

  19. Sequence motifs in MADS transcription factors responsible for specificity and diversification of protein-protein interaction.

    Directory of Open Access Journals (Sweden)

    Aalt D J van Dijk

    Full Text Available Protein sequences encompass tertiary structures and contain information about specific molecular interactions, which in turn determine biological functions of proteins. Knowledge about how protein sequences define interaction specificity is largely missing, in particular for paralogous protein families with high sequence similarity, such as the plant MADS domain transcription factor family. In comparison to the situation in mammalian species, this important family of transcription regulators has expanded enormously in plant species and contains over 100 members in the model plant species Arabidopsis thaliana. Here, we provide insight into the mechanisms that determine protein-protein interaction specificity for the Arabidopsis MADS domain transcription factor family, using an integrated computational and experimental approach. Plant MADS proteins have highly similar amino acid sequences, but their dimerization patterns vary substantially. Our computational analysis uncovered small sequence regions that explain observed differences in dimerization patterns with reasonable accuracy. Furthermore, we show the usefulness of the method for prediction of MADS domain transcription factor interaction networks in other plant species. Introduction of mutations in the predicted interaction motifs demonstrated that single amino acid mutations can have a large effect and lead to loss or gain of specific interactions. In addition, various performed bioinformatics analyses shed light on the way evolution has shaped MADS domain transcription factor interaction specificity. Identified protein-protein interaction motifs appeared to be strongly conserved among orthologs, indicating their evolutionary importance. We also provide evidence that mutations in these motifs can be a source for sub- or neo-functionalization. The analyses presented here take us a step forward in understanding protein-protein interactions and the interplay between protein sequences and

  20. Situation de la pêche aux petits métiers après l'ouverture du nouveau chenal dans la lagune de Nador

    Directory of Open Access Journals (Sweden)

    Mohamed NAJIH

    2015-01-01

    Full Text Available Artisanal fishing is the main socioeconomic activity in Nador lagoon, located on the Mediterranean coast in the North East of Morocco. This activity is not part of the official circuit. In 2009, after the deterioration of water quality, public authorities have decided to open an artificial channel with the aim of improving the circulation of water in the lagoon. This work aims to be an update of the state of knowledge of artisanal fishing in the Nador lagoon, after the opening of the new channel, through a diagnosis based on the exploitation and analysis of socioeconomic indicators. The analysis shows that fishermen operate with six jobs. The annual fishing effort is estimated at 72,385 fishing trips. The overall catch is estimated at 1,157 tons annually for a raw product of 28,180,146 MAD. The economic analysis shows that invested capital is 20,723,000 MAD. For a number of 15.4 fishing trips per month, the monthly net profit per boat is 2,465 MAD. The added value produced by all boats is about 6.3 million MAD.

  1. Treatment of ovarian cancer by targeting the tumor stem cell-associated carbohydrate antigen, Sialyl-Thomsen-nouveau.

    Science.gov (United States)

    Starbuck, Kristen; Al-Alem, Linah; Eavarone, David A; Hernandez, Silvia Fatima; Bellio, Chiara; Prendergast, Jillian M; Stein, Jenna; Dransfield, Daniel T; Zarrella, Bianca; Growdon, Whitfield B; Behrens, Jeff; Foster, Rosemary; Rueda, Bo R

    2018-05-01

    Recurrent ovarian cancer (OvCa) is thought to result in part from the inability to eliminate rare quiescent cancer stem cells (CSCs) that survive cytotoxic chemotherapy and drive tumor resurgence. The Sialyl-Thomsen-nouveau antigen (STn) is a carbohydrate moiety present on protein markers of CSCs in pancreatic, colon, and gastric malignancies. We have demonstrated that human OvCa cell lines contain varying levels of cells that independently express either STn or the ovarian CSC marker CD133. Here we determine co-expression of STn and CD133 in a subset of human OvCa cell lines. Analyses of colony and sphere forming capacity and of response to standard-of-care cytotoxic therapy suggest a subset of OvCa STn + cells display some CSC features. The effect of the anti-STn antibody-drug conjugates (ADCs) S3F-CL-MMAE and 2G12-2B2-CL-MMAE on OvCa cell viability in vitro and in vivo was also assessed. Treatment with S3F-CL-MMAE reduced the viability of two of three OvCa cell lines in vitro and exposure to either S3F-CL-MMAE or 2G12-2B2-CL-MMAE reduced OVCAR3-derived xenograft volume in vivo , depleting STn + tumor cells. In summary, STn + cells demonstrate some stem-like properties and specific therapeutic targeting of STn in ovarian tumors may be an effective clinical strategy to eliminate both STn + CSC and STn + non-CSC populations.

  2. L’exposition prolongée des consommateurs à un nouveau produit permet-elle d’accroître son adoption ?

    OpenAIRE

    Masson, Josselin; Aurier, Philippe; D'hauteville, François

    2010-01-01

    Cette recherche évalue l’effet de la consommation à domicile d’un nouveau produit (le vin à teneur réduite en alcool) sur son acceptabilité à long terme par les consommateurs, et suppose que l’exposition au produit et l’information non-sensorielle influenceront leurs évaluations hédoniques. Deux groupes de consommateurs ont alors été exposés soit à un vin normal, soit à un vin à teneur réduite en alcool, en condition aveugle le premier mois puis avec l’indication de leurs teneurs en alcool le...

  3. Multivariate alteration detection (MAD) in multispectral, bi-temporal image data: A new approach to change detction studies

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg; Conradsen, Knut

    This paper introduces a new orthogonal transformation, the multivariate alteration detection (MAD) transformation, based on an established multivariate statistical technique canonical correlation analysis. The theory for canonical correlation analysis is sketched and a result necessary...... for the definition of the MAD transformation is proven. As opposed to traditional univariate change detection schemes our scheme transforms two sets of multivariate observations (e.g. two multispectral satellite images covering the same geographical area acquired at different points in time) into a difference...... between two linear combinations of the original variables explaining maximal change (i.e. the difference explaining maximal variance) in all variables simultaneously. The MAD transformation is invariant to linear scaling. The MAD transformation can be used iteratively. First, it can be used to detect...

  4. Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast

    Energy Technology Data Exchange (ETDEWEB)

    Shimada, Midori [Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601 (Japan); Yamamoto, Ayumu [Department of Chemistry, Shizuoka University, 836 Ohya, Suruga-ku, Sizuoka 422-8529 (Japan); Murakami-Tonami, Yuko; Nakanishi, Makoto; Yoshida, Takashi [Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601 (Japan); Aiba, Hirofumi [Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa-ku, Nagoya 464-8601 (Japan); Murakami, Hiroshi, E-mail: hmura@med.nagoya-cu.ac.jp [Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601 (Japan)

    2009-10-23

    The spindle checkpoint is a surveillance mechanism that ensures the fidelity of chromosome segregation in mitosis. Here we show that fission yeast casein kinase II (CK2) is required for this checkpoint function. In the CK2 mutants mitosis occurs in the presence of a spindle defect, and the spindle checkpoint protein Mad2p fails to localize to unattached kinetochores. The CK2 mutants are sensitive to the microtubule depolymerising drug thiabendazole, which is counteracted by ectopic expression of mad2{sup +}. The level of Mad2p is low in the CK2 mutants. These results suggest that CK2 has a role in the spindle checkpoint by regulating Mad2p.

  5. Analysis of MADS-Box Gene Family Reveals Conservation in Floral Organ ABCDE Model of Moso Bamboo (Phyllostachys edulis

    Directory of Open Access Journals (Sweden)

    Zhanchao Cheng

    2017-05-01

    Full Text Available Mini chromosome maintenance 1, agamous, deficiens, and serum response factor (MADS-box genes are transcription factors which play fundamental roles in flower development and regulation of floral organ identity. However, till date, identification and functions of MADS-box genes remain largely unclear in Phyllostachys edulis. In view of this, we performed a whole-genome survey and identified 34 MADS-box genes in P. edulis, and based on phylogeny, they were classified as MIKCC, MIKC∗, Mα, and Mβ. The detailed analysis about gene structure and motifs, phylogenetic classification, comparison of gene divergence and duplication are provided. Interestingly, expression patterns for most genes were found similar to those of Arabidopsis and rice, indicating that the well-established ABCDE model can be applied to P. edulis. Moreover, we overexpressed PheMADS15, an AP1-like gene, in Arabidopsis, and found that the transgenic plants have early flowering phenotype, suggesting that PheMADS15 might be a regulator of flowering transition in P. edulis. Taken together, this study provides not only insightful comprehension but also useful information for understanding the functions of MADS-box genes in P. edulis.

  6. MADNESS AND METHOD: THE SYSTEM OF DOCTOR TARR AND PROFESSOR FETHER

    Directory of Open Access Journals (Sweden)

    Luciane Alves Santos

    2014-12-01

    Full Text Available The present study aims to discuss the theme of madness, comparing the narrator’s perspective in “The System of Doctor Tarr and Professor Fether” (1845 and another short stories by Edgar Allan Poe. The analysis illustrates that science in the 19th century aims to remove the fear of the unknown, dominating the natural world and its laws; and that fiction, the presumptive opposite, represents an extension of the same logic under another name. Some writers denied any obligation of loyalty to scientific rationalism and tried to decipher this problem through the dream and the supernatural. Fantastic works of Gothic fiction – Hoffmann’s novels and some of Poe’s stories – illuminate these points. Poe reinterprets the Gothic in the Victorian Age, with an unnamed and often unreliable narrator that insists on his rationality. The comic and grotesque horror result of the psychology of his characters often descended into madness

  7. VISITING THE MUSEUM OF MADNESS: THE EXPERIENCE OF LEARNING ABOUT THE PSYCHIATRIC REFORM

    Directory of Open Access Journals (Sweden)

    Nadja Cristiane Lappann Botti

    2006-04-01

    Full Text Available ABSTRACT: The Museum of Madness in the landscape of the Minas Gerais State is a place where art, history and memory disclose the differences about the Psychiatry approach since the beginning of the last century till nowadays. A qualitative study with 39 nursing undergraduate students was developed, aiming to identify the meaning of the visit to the Museum of Madness. The methodological referential was the Collective Subject Discourse and the theoretical the Brazilian Psychiatric Reform. The data shows the meaning of the visit as potential experience of learning of the dimensions of the Psychiatric Reform when leads the student to question the practice and to know of Psychiatry in the asylum perspective. KEY WORDS: Nursing Education; Mental Health; Health Care Reform.

  8. Mediations on Emergent Occasions: Mad Men, Donald Draper and Frank O’Hara

    Directory of Open Access Journals (Sweden)

    Kate Lilley

    2012-09-01

    Full Text Available Frank O’Hara’s 1957 poetry collection, Meditations in an Emergency, features in Season Two of Mad Men (2008 as a talismanic phrase and object. Pressed into service as Matthew Weiner’s valentine to his returning viewers, the circulation and citation of the book across the season, through different diegetic and extradiegetic levels, aligns poetry, advertising and quality serial television drama as textual modes intent, above all, on creating attachment through feeling. O’Hara’s book is a crucial link in a series of metonymic relays, chain effects and affects, which underwrite Mad Men’s citational poetics to assert its own cultural authority, and the mediating power of television.

  9. Mad og måltider bidrager til dannelse og læring

    DEFF Research Database (Denmark)

    Jacobsen, Mikkel

    2017-01-01

    Vi lever i en kultur der på mange måder knytter vores identitet til mad, fx i forhold til hvad vi poster på sociale medier, om vi køber økologi, stenaldermad, er tykke eller tynde, om vi går op i dyrevelfærd, miljø, osv. Elementer der er med til at skabe vores identitet gennem de valg vi træffer...

  10. Reason and madness in the structure of the Cartesian cogito. Three interpretations of Rene Descartes' Meditation

    Directory of Open Access Journals (Sweden)

    Karachevtseva Larysа Mykolaivna

    2013-06-01

    Full Text Available The article analyses the polemics between Michel Foucault and Jacques Derrida that took place in the sixties of the 20th century. This polemics was dedicated to the elucidation of the role of reason and madness within Cartesian radical doubt – that thought experiment maintained the formula ego cogito ergo sum. The article also examines Emmanuel Levinas's interpretation of Descartes' idea of the infinite. It is shown that the idea of the infinite constitutes cogito.

  11. Evaluation of torque loss value of MAD/MAM zirconia abutments with prefabricated titanium abutments

    OpenAIRE

    Marzieh Alikhasi; Roshanak Baghaie; Nasim khosronejad

    2013-01-01

    Background and Aims: In response to esthetic demand of patients, ceramic abutments have been developed. Despite esthetic of zirconia abutments, machining accuracy of these abutments has always been a question. Any misfit in the abutment-implant interface connection can lead to detorque and screw loosening. The aim of this study was to compare torque loss value of manually aided design/manually aided manufacture (MAD/MAM) zirconia abutments with prefabricated titanium abutments. Materials and ...

  12. Der Sinn des Wahns : Der Mad Scientist und die unmögliche Wissenschaft

    OpenAIRE

    Keller, Felix

    2004-01-01

    Der Text untersucht die Herkunft des verrückten Wissenschaftlers, des Mad Scientist, so wie er in den populären Kultur zelebriert wird. Es wird die Auffassung vertreten, dass der Ursprung der Figur im romantischen Mythos des Genies liegt. Doch wie und weshalb ist es dann zu dieser seltsamen Mutation zum verrückten Wissenschaftler gekommen? Und was berichtet diese Figur über die Wahrnehmung von Wissenschaft?

  13. For a minor art: resonances between art, clinical practice and madness nowadays

    Directory of Open Access Journals (Sweden)

    Elizabeth Maria Freire de Araújo Lima

    2007-01-01

    Full Text Available We discuss the changes that were brought about in Brazil in the 20th century related to the acceptance of works of art produced in clinics or, in any way, other than those conventionally accepted by the artistic community. The enlargement of this field, now including dissenting works of art, seems to indicate a change in contemporary sensibility therefore shifting the relationships between art, clinical practice and madness itself.

  14. A MAD Explanation for the Correlation between Bulk Lorentz Factor and Minimum Variability Timescale

    Science.gov (United States)

    Lloyd-Ronning, Nicole; Lei, Wei-hua; Xie, Wei

    2018-04-01

    We offer an explanation for the anti-correlation between the minimum variability timescale (MTS) in the prompt emission light curve of gamma-ray bursts (GRBs) and the estimated bulk Lorentz factor of these GRBs, in the context of a magnetically arrested disk (MAD) model. In particular, we show that previously derived limits on the maximum available energy per baryon in a Blandford-Znajek jet leads to a relationship between the characteristic MAD timescale in GRBs and the maximum bulk Lorentz factor: tMAD∝Γ-6, somewhat steeper than (although within the error bars of) the fitted relationship found in the GRB data. Similarly, the MAD model also naturally accounts for the observed anti-correlation between MTS and gamma-ray luminosity L in the GRB data, and we estimate the accretion rates of the GRB disk (given these luminosities) in the context of this model. Both of these correlations (MTS - Γ and MTS - L) are also observed in the AGN data, and we discuss the implications of our results in the context of both GRB and blazar systems.

  15. FlyMAD: rapid thermogenetic control of neuronal activity in freely walking Drosophila.

    Science.gov (United States)

    Bath, Daniel E; Stowers, John R; Hörmann, Dorothea; Poehlmann, Andreas; Dickson, Barry J; Straw, Andrew D

    2014-07-01

    Rapidly and selectively modulating the activity of defined neurons in unrestrained animals is a powerful approach in investigating the circuit mechanisms that shape behavior. In Drosophila melanogaster, temperature-sensitive silencers and activators are widely used to control the activities of genetically defined neuronal cell types. A limitation of these thermogenetic approaches, however, has been their poor temporal resolution. Here we introduce FlyMAD (the fly mind-altering device), which allows thermogenetic silencing or activation within seconds or even fractions of a second. Using computer vision, FlyMAD targets an infrared laser to freely walking flies. As a proof of principle, we demonstrated the rapid silencing and activation of neurons involved in locomotion, vision and courtship. The spatial resolution of the focused beam enabled preferential targeting of neurons in the brain or ventral nerve cord. Moreover, the high temporal resolution of FlyMAD allowed us to discover distinct timing relationships for two neuronal cell types previously linked to courtship song.

  16. ["I am but mad north-north-west"--Hamlet's portrayed delusion].

    Science.gov (United States)

    Schulte Herbrüggen, H

    1996-01-01

    Whereas science refers to the real world existing independently and conditioned by cause and effect, the world of literature is fictitious, created by the artist in our imagination by means of language, an artefact conditioned by aesthetic laws, a world sui generis. Accordingly, Hamlet is no person, but a literary figure, doing, saying, thinking and feeling only what the poet dictated him word for word. The essential difference between the two worlds is often overlooked. That "blind spot" has a long-standing tradition in European intellectual history and goes back i.a. to the German "Hamlet experience" in the eighteenth, the "Hamlet fever" and the felt spiritual kinship (Seelenverwandtschaft) in the nineteenth century. Teleological literary criticism, centering around Hamlet's "character" and isolating his psychologically evaluated monologues (e.g. Bradley), refrained from Hamlet's fictionality and role-play and led to blurring beyond recognition the boundaries between real person and literary figure (e.g. Freud, Jones) and assisted in reducing a dramatic role to a medical case history. Speaking of Hamlet, one has to start from Shakespeare's text, our subject matter. A dramatic play being a plot turned into dialogue, the poet's vocabulary used (but indirectly also the vocabulary not used) is particularly informative. When referring to Hamlet's "antic disposition", Shakespeare uses a wide range of over 20 different terms, the most frequented being mad/madness (44 times). Evidence of primary importance are the five occasions after the apparition of his father's ghost, when Hamlet speaks of hist "madness" as an assumed role. In Act I "madness occurs first as a mere possibility when Hamlet informs his friends, he might "put an antic disposition on"; in Act II vis-a-vis Rosencrantz and Guildenstern ("I am but mad north-north-west") it is his deliberate action under certain conditions; in Act III it occurs thrice, first in his declaration of intent ("They are coming to

  17. Patterns of MADS-box gene expression mark flower-type development in Gerbera hybrida (Asteraceae

    Directory of Open Access Journals (Sweden)

    Teeri Teemu H

    2006-06-01

    Full Text Available Abstract Background The inflorescence of the cut-flower crop Gerbera hybrida (Asteraceae consists of two principal flower types, ray and disc, which form a tightly packed head, or capitulum. Despite great interest in plant morphological evolution and the tractability of the gerbera system, very little is known regarding genetic mechanisms involved in flower type specification. Here, we provide comparative staging of ray and disc flower development and microarray screening for differentially expressed genes, accomplished via microdissection of hundreds of coordinately developing flower primordia. Results Using a 9K gerbera cDNA microarray we identified a number of genes with putative specificity to individual flower types. Intrestingly, several of these encode homologs of MADS-box transcription factors otherwise known to regulate flower organ development. From these and previously obtained data, we hypothesize the functions and protein-protein interactions of several gerbera MADS-box factors. Conclusion Our RNA expression results suggest that flower-type specific MADS protein complexes may play a central role in differential development of ray and disc flowers across the gerbera capitulum, and that some commonality is shared with known protein functions in floral organ determination. These findings support the intriguing conjecture that the gerbera flowering head is more than a mere floral analog at the level of gene regulation.

  18. Evaluation of torque loss value of MAD/MAM zirconia abutments with prefabricated titanium abutments

    Directory of Open Access Journals (Sweden)

    Marzieh Alikhasi

    2013-04-01

    Full Text Available Background and Aims: In response to esthetic demand of patients, ceramic abutments have been developed. Despite esthetic of zirconia abutments, machining accuracy of these abutments has always been a question. Any misfit in the abutment-implant interface connection can lead to detorque and screw loosening. The aim of this study was to compare torque loss value of manually aided design/manually aided manufacture (MAD/MAM zirconia abutments with prefabricated titanium abutments. Materials and Methods: Seven titanium abutments (Branemark RP, Easy abutment and seven copy milled abutments which were duplicated from the prefabricated Zirkonzhan (ZirkonZahn, Sand in Taufers, Italy were prepared. After sintering process of zirconia abutment, all abutments were fastened with a torque screw under 35 Ncm. Detorque measurements were performed per group pushing the reverse button of the Torque controller soon after screw tightening with values registered. The mean torque loss were calculated and compared using Student's t test. Results: The mean of torque loss was 12.71 Ncm with standard deviation of 1.70 for prefabricated titanium abutments and 15.50 Ncm with standard deviation of 4.67 for MAD-MAM abutments. The difference between the two groups was not statistically significant (P=0.23. Conclusion: Within the limitation of this study, MAD-MAM ceramic abutments could maintain the applied torque comparing to the prefabricated abutments.

  19. Dual personality of Mad1: regulation of nuclear import by a spindle assembly checkpoint protein.

    Science.gov (United States)

    Cairo, Lucas V; Ptak, Christopher; Wozniak, Richard W

    2013-01-01

    Nuclear transport is a dynamic process that can be modulated in response to changes in cellular physiology. We recently reported that the transport activity of yeast nuclear pore complexes (NPCs) is altered in response to kinetochore-microtubule (KT-MT) interaction defects. Specifically, KT detachment from MTs activates a signaling pathway that prevents the nuclear import of cargos by the nuclear transport factor Kap121p. This loss of Kap121p-mediated import is thought to influence the nuclear environment, including the phosphorylation state of nuclear proteins. A key regulator of this process is the spindle assembly checkpoint protein Mad1p. In response to unattached KTs, Mad1p dynamically cycles between NPCs and KTs. This cycling appears to induce NPC molecular rearrangements that prevent the nuclear import of Kap121p-cargo complexes. Here, we discuss the underlying mechanisms and the physiological relevance of Mad1p cycling and the inhibition of Kap121p-mediated nuclear import, focusing on outstanding questions within the pathway.

  20. The social structure of the medical model of madness and the physician's role.

    Science.gov (United States)

    Fernandez, G

    1981-08-01

    In this paper the origins of the medical model of madness are traced in the sociohistorical context of institutional and professional development. The paper establishes the emergence of the three primary conditions necessary for the medical model to exist: (a) the view that madness is a separate ontological reality which can be differentiated from the insane person; (b) the concept that insane people do not have a completely free will and therefore cannot be held responsible for their actions; and (c) the creation of specific criteria to classify the disease into empirically derived nosologies. These conditions and their acceptance as an explanatory paradigm of insanity result from the political economy of the late Middle Ages and are reflected in the institutional arrangement for insane persons of the 17th and 18th centuries. Finally, the role of the physician-psychiatrist is explained in terms of an ability to (a) serve as a technician for the new political forces, and (b) dislodge the moral entrepreneurs and become the only profession able to offer a proper scientific and secular treatment of madness. The psychiatrist is presented as a by-product of the dominance of the medical model rather than as the agent who created it.

  1. The Duty of the ANARAP-MAD for the Development of Radiation Protection in Madagascar

    International Nuclear Information System (INIS)

    Ratovonjanahary, F.

    2010-01-01

    Association NAtionale de Radio Protection-MADagascar (ANARAP-MAD), to develop the radiation protection in Madagascar; to promote the radiation protection in Madagascar; to set up links with international institutions dealing with the same objectives (I.A.E.A., W.H.O., etc...); to care for the enforcement of the regulation in radiation protection; to propose improvements and amendments; to find solutions to problems relevant to the enforcement of the regulation; to inform and to train in the field of radiation protection; to contribute in the development of the science, all activities carried out by the association are based on the existing legislation in the country. Despite the insufficiency of financial support, the ANARAP-MAD had always made an effort to carry out activities for the development of radiation protection infrastructure in Madagascar. The main problem is also that the regulatory Authority is not yet operational. However, the ANARAP-MAD, with the support of the Madagascar-INSTN, has the challenge to effectively promoting radiation protection in Madagascar

  2. Wind farm development project at Mount Copper and Miller at Murdochville : public inquiry report; Projets d'amenagement des parcs d'eoliennes des monts Copper et Miller a Murdochville : rapport d'enquete et d'audience publique

    Energy Technology Data Exchange (ETDEWEB)

    Harvie, A.

    2004-03-01

    A public hearing was held at the request of the Quebec Minister of the Environment to examine the environmental and socio-economic impacts of a proposed wind farm project at Mount Copper and Mount Miller in Murdochville, Quebec. The first phase of the project involves the construction of a wind turbine array with a capacity of 9 megawatts (MW), followed by a second phase expansion to 45 MW for 2004. The final wind turbine array includes 36 turbines for a total capacity of 54 megawatts (MW). The region is well suited for wind energy projects. Energie Eolienne du Mont Miller Inc. and Northland Power Inc. intend to develop the wind farm at a cost of approximately $90 million. Hydro Quebec has agreed to purchase the electricity. The various impacts of the proposed project were examined, both from an environmental and a socio-economic perspective. The Commission determined that the wind farm would not have significant impacts and that the project is desirable. Certain conditions must be met to ensure sustainable development. In terms of ecology, the Commission would like to have a complete inventory of the bird species and a description of the corridors of migration. It would also like to see the promoters show leadership in minimizing the impacts of the project on the ecotourism activities offered in the area. 17 refs., 1 tab., 1 fig., 2 appendices.

  3. Genome-wide characterization of the MADS-box gene family in radish (Raphanus sativus L. and assessment of its roles in flowering and floral organogenesis

    Directory of Open Access Journals (Sweden)

    Chao Li

    2016-09-01

    Full Text Available The MADS-box gene family is an important transcription factor (TF family that is involved in various aspects of plant growth and development, especially flowering time and floral organogenesis. Although it has been reported in many plant species, the systematic identification and characterization of MADS-box TF family is still limited in radish (Raphanus sativus L.. In the present study, a comprehensive analysis of MADS-box genes was performed, and a total of 144 MADS-box family members were identified from the whole radish genome. Meanwhile, a detailed list of MADS-box genes from other 28 plant species was also investigated. Through the phylogenetic analysis between radish and Arabidopsis thaliana, all the RsMADS genes were classified into two groups including 68 type I (31 Mα, 12 Mβ and 25Mγ and 76 type II (70 MIKCC and 6 MIKC*. Among them, 41 (28.47% RsMADS genes were located in nine linkage groups of radish from R1 to R9. Moreover, the homologous MADS-box gene pairs were identified among radish, A. thaliana, Chinese cabbage and rice. Additionally, the expression profiles of RsMADS genes were systematically investigated in different tissues and growth stages. Furthermore, quantitative real-time PCR analysis was employed to validate expression patterns of some crucial RsMADS genes. These results could provide a valuable resource to explore the potential functions of RsMADS genes in radish, and facilitate dissecting MADS-box gene-mediated molecular mechanisms underlying flowering and floral organogenesis in root vegetable crops.

  4. Clinical and laboratory findings in mad honey poisoning: a single center experience.

    Science.gov (United States)

    Yaylaci, S; Kocayigit, I; Aydin, E; Osken, A; Genc, A B; Cakar, M A; Tamer, A

    2014-01-01

    This study is aimed at analyzing the demographic and clinical characteristics, as well as the hematological-biochemical parameters of patients who admitted to the hospital with the diagnosis of mad honey poisoning. A total of 16 patients who were admitted with mad honey intoxication symptoms and treated in Emergency Department of Sakarya Education and Research Hospital between January 2009 and December 2012 were included in the study. Demographic and clinical characteristics of the patients and hematological, biochemical parameters were obtained from hospital records. Heart rate, systolic and diastolic blood pressure on admission and at discharge were obtained retrospectively. Sixteen patients (10 males and 6 females, mean age 58.5 ± 10 years, range between 41 and 79) were included in our study. Heart rate was 42 ± 6 beats/min, systolic blood pressure was 73 ± 19 mmHg, and diastolic blood pressure was 45 ± 17 mmHg on admission. In the evaluation of the patients' heart rhythms on admission to the emergency room, nine (56.3%) patients had sinus bradycardia, three (18.8%) patients had nodal rhythm, two (12.5%) patients had first degree atrioventricular block, and two (12.5%) patients had atrial fibrillation. Atropine 1.1 ± 0.4 mg and saline 1125 ± 465 ml were used to treat patients. Patients were discharged with a stable condition after an average 27.7 ± 7.2 h of follow-up. Heart rate was 75 ± 8 beats/min, systolic blood pressure was 132 ± 7 mmHg, and diastolic blood pressure was 82 ± 6 mmHg at discharge. Mortality was not observed. Hematological and biochemical parameters measured at the time of admission were within normal ranges. Mad honey poisoning should be considered in previously healthy patients with unexplained symptoms of bradycardia, hypotension, and cardiac dysrhythmias. Therefore, diet history should carefully be obtained from the patients admitted with bradycardia and hypotension, and mad honey intoxication should also be considered in the

  5. Genome-wide identification, characterisation and expression analysis of the MADS-box gene family in Prunus mume.

    Science.gov (United States)

    Xu, Zongda; Zhang, Qixiang; Sun, Lidan; Du, Dongliang; Cheng, Tangren; Pan, Huitang; Yang, Weiru; Wang, Jia

    2014-10-01

    MADS-box genes encode transcription factors that play crucial roles in plant development, especially in flower and fruit development. To gain insight into this gene family in Prunus mume, an important ornamental and fruit plant in East Asia, and to elucidate their roles in flower organ determination and fruit development, we performed a genome-wide identification, characterisation and expression analysis of MADS-box genes in this Rosaceae tree. In this study, 80 MADS-box genes were identified in P. mume and categorised into MIKC, Mα, Mβ, Mγ and Mδ groups based on gene structures and phylogenetic relationships. The MIKC group could be further classified into 12 subfamilies. The FLC subfamily was absent in P. mume and the six tandemly arranged DAM genes might experience a species-specific evolution process in P. mume. The MADS-box gene family might experience an evolution process from MIKC genes to Mδ genes to Mα, Mβ and Mγ genes. The expression analysis suggests that P. mume MADS-box genes have diverse functions in P. mume development and the functions of duplicated genes diverged after the duplication events. In addition to its involvement in the development of female gametophytes, type I genes also play roles in male gametophytes development. In conclusion, this study adds to our understanding of the roles that the MADS-box genes played in flower and fruit development and lays a foundation for selecting candidate genes for functional studies in P. mume and other species. Furthermore, this study also provides a basis to study the evolution of the MADS-box family.

  6. A Modular GIS-Based Software Architecture for Model Parameter Estimation using the Method of Anchored Distributions (MAD)

    Science.gov (United States)

    Ames, D. P.; Osorio-Murillo, C.; Over, M. W.; Rubin, Y.

    2012-12-01

    The Method of Anchored Distributions (MAD) is an inverse modeling technique that is well-suited for estimation of spatially varying parameter fields using limited observations and Bayesian methods. This presentation will discuss the design, development, and testing of a free software implementation of the MAD technique using the open source DotSpatial geographic information system (GIS) framework, R statistical software, and the MODFLOW groundwater model. This new tool, dubbed MAD-GIS, is built using a modular architecture that supports the integration of external analytical tools and models for key computational processes including a forward model (e.g. MODFLOW, HYDRUS) and geostatistical analysis (e.g. R, GSLIB). The GIS-based graphical user interface provides a relatively simple way for new users of the technique to prepare the spatial domain, to identify observation and anchor points, to perform the MAD analysis using a selected forward model, and to view results. MAD-GIS uses the Managed Extensibility Framework (MEF) provided by the Microsoft .NET programming platform to support integration of different modeling and analytical tools at run-time through a custom "driver." Each driver establishes a connection with external programs through a programming interface, which provides the elements for communicating with core MAD software. This presentation gives an example of adapting the MODFLOW to serve as the external forward model in MAD-GIS for inferring the distribution functions of key MODFLOW parameters. Additional drivers for other models are being developed and it is expected that the open source nature of the project will engender the development of additional model drivers by 3rd party scientists.

  7. Systematic notes on Asian birds. 10. The “Nouveau recueil de planches coloriées” of Temminck & Laugier (1820-1839): the little known impression of 1850

    NARCIS (Netherlands)

    Sayako, N.; Dickinson, E.C.

    2001-01-01

    A copy of the reported 1850 impression of the “Nouveau recueil de planches coloriées” that has recently come to light suggests that bound copies would be virtually indistinguishable from the first edition (1820-1839) despite the different publisher. In spite of clear statements by the publisher, we

  8. Characterization of an AGAMOUS-like MADS Box Protein, a Probable Constituent of Flowering and Fruit Ripening Regulatory System in Banana

    Science.gov (United States)

    Roy Choudhury, Swarup; Roy, Sujit; Nag, Anish; Singh, Sanjay Kumar; Sengupta, Dibyendu N.

    2012-01-01

    The MADS-box family of genes has been shown to play a significant role in the development of reproductive organs, including dry and fleshy fruits. In this study, the molecular properties of an AGAMOUS like MADS box transcription factor in banana cultivar Giant governor (Musa sp, AAA group, subgroup Cavendish) has been elucidated. We have detected a CArG-box sequence binding AGAMOUS MADS-box protein in banana flower and fruit nuclear extracts in DNA-protein interaction assays. The protein fraction in the DNA-protein complex was analyzed by mass spectrometry and using this information we have obtained the full length cDNA of the corresponding protein. The deduced protein sequence showed ∼95% amino acid sequence homology with MA-MADS5, a MADS-box protein described previously from banana. We have characterized the domains of the identified AGAMOUS MADS-box protein involved in DNA binding and homodimer formation in vitro using full-length and truncated versions of affinity purified recombinant proteins. Furthermore, in order to gain insight about how DNA bending is achieved by this MADS-box factor, we performed circular permutation and phasing analysis using the wild type recombinant protein. The AGAMOUS MADS-box protein identified in this study has been found to predominantly accumulate in the climacteric fruit pulp and also in female flower ovary. In vivo and in vitro assays have revealed specific binding of the identified AGAMOUS MADS-box protein to CArG-box sequence in the promoters of major ripening genes in banana fruit. Overall, the expression patterns of this MADS-box protein in banana female flower ovary and during various phases of fruit ripening along with the interaction of the protein to the CArG-box sequence in the promoters of major ripening genes lead to interesting assumption about the possible involvement of this AGAMOUS MADS-box factor in banana fruit ripening and floral reproductive organ development. PMID:22984496

  9. Overexpression of a novel MADS-box gene SlFYFL delays senescence, fruit ripening and abscission in tomato

    Science.gov (United States)

    Xie, Qiaoli; Hu, Zongli; Zhu, Zhiguo; Dong, Tingting; Zhao, Zhiping; Cui, Baolu; Chen, Guoping

    2014-03-01

    MADS-domain proteins are important transcription factors involved in many biological processes of plants. In our study, a tomato MADS-box gene, SlFYFL, was isolated. SlFYFL is expressed in all tissues of tomato and significantly higher in mature leave, fruit of different stages, AZ (abscission zone) and sepal. Delayed leaf senescence and fruit ripening, increased storability and longer sepals were observed in 35S:FYFL tomato. The accumulation of carotenoid was reduced, and ethylene content, ethylene biosynthetic and responsive genes were down-regulated in 35S:FYFL fruits. Abscission zone (AZ) did not form normally and abscission zone development related genes were declined in AZs of 35S:FYFL plants. Yeast two-hybrid assay revealed that SlFYFL protein could interact with SlMADS-RIN, SlMADS1 and SlJOINTLESS, respectively. These results suggest that overexpression of SlFYFL regulate fruit ripening and development of AZ via interactions with the ripening and abscission zone-related MADS box proteins.

  10. Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast

    Directory of Open Access Journals (Sweden)

    John C. Meadows

    2017-02-01

    Full Text Available The onset of anaphase is triggered by activation of the anaphase-promoting complex/cyclosome (APC/C following silencing of the spindle assembly checkpoint (SAC. APC/C triggers ubiquitination of Securin and Cyclin B, which leads to loss of sister chromatid cohesion and inactivation of Cyclin B/Cdk1, respectively. This promotes relocalization of Aurora B kinase and other components of the chromosome passenger complex (CPC from centromeres to the spindle midzone. In fission yeast, this is mediated by Clp1 phosphatase-dependent interaction of CPC with Klp9/MKLP2 (kinesin-6. When this interaction is disrupted, kinetochores bi-orient normally, but APC/C activation is delayed via a mechanism that requires Sgo2 and some (Bub1, Mph1/Mps1, and Mad3, but not all (Mad1 and Mad2, components of the SAC and the first, but not second, lysine, glutamic acid, glutamine (KEN box in Mad3. These data indicate that interaction of CPC with Klp9 terminates a Sgo2-dependent, but Mad2-independent, APC/C-inhibitory pathway that is distinct from the canonical SAC.

  11. Regulatory role of OsMADS34 in the determination of glumes fate, grain yield and quality in rice

    Directory of Open Access Journals (Sweden)

    Deyong Ren

    2016-12-01

    Full Text Available Grasses produce seeds on spikelets, a unique type of inflorescence. Despite the importance of grass crops for food, the genetic mechanisms that control spikelet development remain poorly understood. In this study, we used m34-z, a new mutant allele of the rice (Oryza sativa E-class gene OsMADS34, to examine OsMADS34 function in determining the identities of glumes (rudimentary glume and sterile lemma and grain size. In the m34-z mutant, both the rudimentary glume and sterile lemma were homeotically converted to the lemma-like organs and acquired the lemma identity, suggesting that OsMADS34 plays important roles in the development of glumes. In the m34-z mutant, most of the grains from the secondary panicle branches were decreased in size, compared with grains from wild type, but no differences were observed in the grains from the primary panicle branches. The amylose content and gel consistency, and a seed-setting rate from the secondary panicle branches were reduced in the m34-z mutant. Interesting, transcriptional activity analysis revealed that OsMADS34 protein was a transcription repressor and it may influence grain yield by suppressing the expressions of BG1, GW8, GW2 and GL7 in the m34-z mutant. These findings revealed that OsMADS34 largely affects grain yield by affecting the size of grains from the secondary branches.

  12. Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxel.

    Science.gov (United States)

    Tambe, Mahesh; Pruikkonen, Sofia; Mäki-Jouppila, Jenni; Chen, Ping; Elgaaen, Bente Vilming; Straume, Anne Hege; Huhtinen, Kaisa; Cárpen, Olli; Lønning, Per Eystein; Davidson, Ben; Hautaniemi, Sampsa; Kallio, Marko J

    2016-03-15

    The molecular pathways that contribute to the proliferation and drug response of cancer cells are highly complex and currently insufficiently characterized. We have identified a previously unknown microRNA-based mechanism that provides cancer cells means to stimulate tumorigenesis via increased genomic instability and, at the same time, evade the action of clinically utilized microtubule drugs. We demonstrate miR-493-3p to be a novel negative regulator of mitotic arrest deficient-2 (MAD2), an essential component of the spindle assembly checkpoint that monitors the fidelity of chromosome segregation. The microRNA targets the 3' UTR of Mad2 mRNA thereby preventing translation of the Mad2 protein. In cancer cells, overexpression of miR-493-3p induced a premature mitotic exit that led to increased frequency of aneuploidy and cellular senescence in the progeny cells. Importantly, excess of the miR-493-3p conferred resistance of cancer cells to microtubule drugs. In human neoplasms, miR-493-3p and Mad2 expression alterations correlated with advanced ovarian cancer forms and high miR-493-3p levels were associated with reduced survival of ovarian and breast cancer patients with aggressive tumors, especially in the paclitaxel therapy arm. Our results suggest that intratumoral profiling of miR-493-3p and Mad2 levels can have diagnostic value in predicting the efficacy of taxane chemotherapy.

  13. ¿Qué Teoría? La Teoría en Mad Money | What Theory? The Theory in Mad Money

    Directory of Open Access Journals (Sweden)

    Susan STRANGE

    2012-10-01

    Full Text Available Mad Money (Manchester University Press, 1998 es la versión completamente reescrita y actualizada de Casino Capitalism (Blackwells, 1986. Se ha sugerido —de ambos volúmenes— que no había en ellos una teoría subyacente en la discusión de Strange sobre el sistema financiero internacional. Esto, argumenta Strange en este working paper, no es en absoluto el caso. Los dos volúmenes se sustentan, siempre implícitamente y a veces explícitamente, en los temas dominantes del trabajo de Strange desde la publicación de "International Relations and International Economics: A Case of Mutual Neglect", International Affairs, 46, (2, 1970. Se trata de tres temas: primero, una necesidad de privilegiar las políticas del sistema financiero internacional en el estudio de las relaciones internacionales; una disciplina miope desde hace mucho, concentrada en el conflicto violento y en la guerra entre estados, a expensas de todo el resto. Segundo, una necesidad de ir más alla de la teoría política y económica liberal y de reconocer el significado del "poder estructural" en el sistema internacional. Tercero, una necesidad de reconocer que las "áreas de ignorancia significativa" dentro de nuestra comprensión del rol del sistema financiero internacional en una era de revolución tecnológica y globalización son cada vez mayores. Para Strange, el poder estructural del capital no es constante y, por ende, no puede acomodarse en la lógica de la economía liberal. Así, usando la definición de "loco" del diccionario —comportamiento errático, impredecible e irracional que daña no solo a quien lo sufre sino también a otros—, tenemos, como ella dice, un "dinero loco"."Mad Money" (Manchester University Press, 1998 is the completely rewritten and updated version of "Casino Capitalism" (Blackwells, 1986. It has been suggested —of both volumes— that there was no theory underlying Strange's discussion of the international financial system in them

  14. Métallogénie du gîte à PB-ZN-AG de Nicholas-Denys, Nouveau-Brunswick

    OpenAIRE

    Deakin, Michelle Kyle

    2011-01-01

    Le gîte à Pb–Zn–Ag de Nicholas-Denys, dans le camp minier de Bathurst (Nouveau-Brunswick), est constitué de plusieurs lentilles à pyrrhotite–sphalérite–galène, encaissées par le mudstone de la Formation de Millstream du Groupe de Fournier, déposé dans un bassin d’arrière-arc ordovicien. Les lentilles de sulfures sont concordantes avec la foliation régional S1, et sont boudinées parallèlement à la faille de Rocky-Brook Millstream, indiquant que les sulfures prédatent la déformation décrochante...

  15. L’identità narrativa ricœuriana alla prova del «nouveau roman» di Robbe-Grillet

    Directory of Open Access Journals (Sweden)

    Alberto Romele

    2013-12-01

    Full Text Available The present essay aims to connect Ricœur’s notion of narrative identity – developed between the 1980s and 1990s – with the nouveau roman theorized by Alain Robbe-Grillet in writings published between 1956 and 1963 and then collected in Pour un noveau roman. In the first part, the essay will summarize Ricœur’s  Aristotelian –apocalyptic narratology model in the light of a comparison with the work of Frank Kermode. In the second part, noveau roman’s ontic realism will be presented. Finally, in the third part, starting with a comparison with the world of computer games, the essay will trace the effect of the overlapping of noveau roman with narrative identity both on the level of description and prescription.

  16. Socio-Economic Problems of the Russian Construction of Art Nouveau Period (on the Example of A.I. Lishnevsky’s Activity

    Directory of Open Access Journals (Sweden)

    Aleksandr I. Chepel

    2017-09-01

    Full Text Available The author studies the specifics of Russian architect’s work on the example of the activity of prominent architect of Art Nouveau period A.L. Lishnevsky (1868–1942. The special attention is paid to the architect’s relations with the authorities, contractors and workers, as well as with customers and colleagues. The author shows the opinion of citizens about the activities of an architect as a builder and businessman, reveals the main socio-economic problems which the architect faced from the moment of inception and approval of the project prior to its actual implementation. The author attempts to trace the mechanism of professional networking in the architecture environment of that time, and to reveal the peculiarities of private architectural bureaus (“offices”. The attention is paid to the assessment by the architect of their own professional activity. A.L. Lishnevsky’s activity is a good example of architect’s work in the construction business. A native of the city of Kherson, he received the metropolitan education at the Art Academy, then for over six years (1895–1901 he worked as a municipal architect in Elisavetgrad (Kirovograd, since 2016 – Kropivnytsky during the period of rapid economic and cultural growth of the town. After 1901 and up to 1917 he was actively engaged in municipal and private construction in the capital of the Russian Empire, Saint Petersburg. The relevance of the topic is determined by the fact that the Art Nouveau period architect worked in capitalism construction market, and was forced to deal with issues similar to those that the architects of our time solve. The study is based on materials from Russian archives and periodicals of late 19th – early 20th century.

  17. Escherichia coli MltA : MAD phasing and refinement of a tetartohedrally twinned protein crystal structure (vol D61, pg 613, 2005)

    NARCIS (Netherlands)

    Barends, Thomas R.M.; Jong, René M. de; Straaten, Karin E. van; Thunnissen, Andy-Mark W.H.; Dijkstra, Bauke W.

    Crystals were grown of a mutant form of the bacterial cell-wall maintenance protein MltA that diffracted to 2.15 Å resolution. When phasing with molecular replacement using the native structure failed, selenium MAD was used to obtain initial phases. However, after MAD phasing the crystals were found

  18. Divergence of recently duplicated M{gamma}-type MADS-box genes in Petunia.

    Science.gov (United States)

    Bemer, Marian; Gordon, Jonathan; Weterings, Koen; Angenent, Gerco C

    2010-02-01

    The MADS-box transcription factor family has expanded considerably in plants via gene and genome duplications and can be subdivided into type I and MIKC-type genes. The two gene classes show a different evolutionary history. Whereas the MIKC-type genes originated during ancient genome duplications, as well as during more recent events, the type I loci appear to experience high turnover with many recent duplications. This different mode of origin also suggests a different fate for the type I duplicates, which are thought to have a higher chance to become silenced or lost from the genome. To get more insight into the evolution of the type I MADS-box genes, we isolated nine type I genes from Petunia, which belong to the Mgamma subclass, and investigated the divergence of their coding and regulatory regions. The isolated genes could be subdivided into two categories: two genes were highly similar to Arabidopsis Mgamma-type genes, whereas the other seven genes showed less similarity to Arabidopsis genes and originated more recently. Two of the recently duplicated genes were found to contain deleterious mutations in their coding regions, and expression analysis revealed that a third paralog was silenced by mutations in its regulatory region. However, in addition to the three genes that were subjected to nonfunctionalization, we also found evidence for neofunctionalization of one of the Petunia Mgamma-type genes. Our study shows a rapid divergence of recently duplicated Mgamma-type MADS-box genes and suggests that redundancy among type I paralogs may be less common than expected.

  19. From MAD to SAD: The Italian experience for the low-frequency aperture array of SKA1-LOW

    Science.gov (United States)

    Bolli, P.; Pupillo, G.; Virone, G.; Farooqui, M. Z.; Lingua, A.; Mattana, A.; Monari, J.; Murgia, M.; Naldi, G.; Paonessa, F.; Perini, F.; Pluchino, S.; Rusticelli, S.; Schiaffino, M.; Schillirò, F.; Tartarini, G.; Tibaldi, A.

    2016-03-01

    This paper describes two small aperture array demonstrators called Medicina and Sardinia Array Demonstrators (MAD and SAD, respectively). The objectives of these instruments are to acquire experience and test new technologies for a possible application to the low-frequency aperture array of the low-frequency telescope of the Square Kilometer Array phase 1 (SKA1-LOW). The MAD experience was concluded in 2014, and it turned out to be an important test bench for implementing calibration techniques based on an artificial source mounted in an aerial vehicle. SAD is based on 128 dual-polarized Vivaldi antennas and is 1 order of magnitude larger than MAD. The architecture and the station size of SAD, which is along the construction phase, are more similar to those under evaluation for SKA1-LOW, and therefore, SAD is expected to provide useful hints for SKA1-LOW.

  20. [Foucault, Derrida, and the history of madness: notes on a controversy].

    Science.gov (United States)

    Pereira Neto, A F

    1998-01-01

    The publication of the book Folie et Déraison. Histoire de la Folie à l'Age Classique (1961), by Michel Foucault, sparked a debate between the author and philosopher Jacques Derrida during the 1960s and 70s. Derrida criticized the methodological proposal and organization of the History of Madness presented by Foucault in the foreword to the first edition. The controversy appears to have motivated the author to withdraw this same foreword from the second edition. The purpose of this article is to analyze some current points in this controversy. It also presents a research agenda for an understanding of the reasons leading Foucault to take this stance.

  1. The Killer Will Remain Free: On Pat Parker and the Poetics of Madness.

    Science.gov (United States)

    Ali, Kazim

    2015-01-01

    Poet and scholar Kazim Ali reads Pat Parker's Movement in Black intimately, one poet to another, uncovering the shadow-fact of the lives of most people of color: not only the anger that is somehow sublimated into every part of our lives but also the issue that carrying this feeling around has on our mental health itself-that "anger" and "madness" might have sources in one another. Ali concludes that Parker offers a brutal and clear-eyed and ultimately hopeful assessment of the conditions that were faced at the time, and even now, by communities of color.

  2. Automatic change detection in RapidEye data using the combined MAD and kernel MAF methods

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg; Hecheltjen, Antje; Thonfeld, Frank

    2010-01-01

    The IR-MAD components show changes for a large part of the entire subset. Especially phenological changes in the agricultural fields surrounding the open pit are predominant. As opposed to this, kMAF components focus more on changes in the open-cast mine (and changes due to the two clouds...... and their shadows, not visible in the zoom). Ground data were available from bucket-wheel excavators on the extraction side (to the northwest in the open pit) in terms of elevation data for both dates. No ground data were available for changes due to backfill (southeastern part of the open pit) or changes due...

  3. Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer.

    LENUS (Irish Health Repository)

    Furlong, Fiona

    2012-04-01

    Epithelial ovarian cancer (EOC) has an innate susceptibility to become chemoresistant. Up to 30% of patients do not respond to conventional chemotherapy [paclitaxel (Taxol®) in combination with carboplatin] and, of those who have an initial response, many patients relapse. Therefore, an understanding of the molecular mechanisms that regulate cellular chemotherapeutic responses in EOC cells has the potential to impact significantly on patient outcome. The mitotic arrest deficiency protein 2 (MAD2), is a centrally important mediator of the cellular response to paclitaxel. MAD2 immunohistochemical analysis was performed on 82 high-grade serous EOC samples. A multivariate Cox regression analysis of nuclear MAD2 IHC intensity adjusting for stage, tumour grade and optimum surgical debulking revealed that low MAD2 IHC staining intensity was significantly associated with reduced progression-free survival (PFS) (p = 0.0003), with a hazard ratio of 4.689. The in vitro analyses of five ovarian cancer cell lines demonstrated that cells with low MAD2 expression were less sensitive to paclitaxel. Furthermore, paclitaxel-induced activation of the spindle assembly checkpoint (SAC) and apoptotic cell death was abrogated in cells transfected with MAD2 siRNA. In silico analysis identified a miR-433 binding domain in the MAD2 3\\' UTR, which was verified in a series of experiments. Firstly, MAD2 protein expression levels were down-regulated in pre-miR-433 transfected A2780 cells. Secondly, pre-miR-433 suppressed the activity of a reporter construct containing the 3\\'-UTR of MAD2. Thirdly, blocking miR-433 binding to the MAD2 3\\' UTR protected MAD2 from miR-433 induced protein down-regulation. Importantly, reduced MAD2 protein expression in pre-miR-433-transfected A2780 cells rendered these cells less sensitive to paclitaxel. In conclusion, loss of MAD2 protein expression results in increased resistance to paclitaxel in EOC cells. Measuring MAD2 IHC staining intensity may predict

  4. Metformin Protects Neurons against Oxygen-Glucose Deprivation/Reoxygenation -Induced Injury by Down-Regulating MAD2B.

    Science.gov (United States)

    Meng, Xianfang; Chu, Guangpin; Yang, Zhihua; Qiu, Ping; Hu, Yue; Chen, Xiaohe; Peng, Wenpeng; Ye, Chen; He, Fang-Fang; Zhang, Chun

    2016-01-01

    Metformin, the common medication for type II diabetes, has protective effects on cerebral ischemia. However, the molecular mechanisms are far from clear. Mitotic arrest deficient 2-like protein 2 (MAD2B), an inhibitor of the anaphase-promoting complex (APC), is widely expressed in hippocampal and cortical neurons and plays an important role in mediating high glucose-induced neurotoxicity. The present study investigated whether metformin modifies the expression of MAD2B and to exert its neuroprotective effects in primary cultured cortical neurons during oxygen-glucose deprivation/reoxygenation (OGD/R), a widely used in vitro model of ischemia/reperfusion. Primary cortical neurons were cultured, deprived of oxygen-glucose for 1 h, and then recovered with oxygen-glucose for 12 h and 24 h. Cell viability was measured by detecting the levels of lactate dehydrogenase (LDH) in culture medium. The levels of MAD2B, cyclin B and p-histone 3 were measured by Western blot. Cell viability of neurons was reduced under oxygen-glucose deprivation/reoxygenation (OGD/R). The expression of MAD2B was increased under OGD/R. The levels of cyclin B1, which is a substrate of APC, were also increased. Moreover, OGD/R up-regulated the phosphorylation levels of histone 3, which is the induction of aberrant re-entry of post-mitotic neurons. However, pretreatment of neurons with metformin alleviated OGD/R-induced injury. Metformin further decreased the expression of MAD2B, cyclin B1 and phosphorylation levels of histone 3. Metformin exerts its neuroprotective effect through regulating the expression of MAD2B in neurons under OGD/R. © 2016 The Author(s) Published by S. Karger AG, Basel.

  5. Pharmacology and psychiatry at the origins of Greek medicine: The myth of Melampus and the madness of the Proetides.

    Science.gov (United States)

    Olivieri, Matteo F; Marzari, Francesca; Kesel, Andreas J; Bonalume, Laura; Saettini, Francesco

    2017-01-01

    Melampus is a seer-healer of Greek myth attributed with having healed the young princesses of Argos of madness. Analysis of this legend and its sources sheds light on the early stages of the "medicalizing" shift in the history of ancient Greek medicine. Retrospective psychological diagnosis suggests that the descriptions of the youths' madness rose from actual observation of behavioral and mental disorders. Melampus is credited with having healed them by administering hellebore. Pharmacological analysis of botanical specimens proves that Helleborus niger features actual neurological properties effective in the treatment of mental disorders. The discussion aims at examining the rational aspects of the treatment of mental conditions in Greco-Roman antiquity.

  6. Validation of Cut-Points for Evaluating the Intensity of Physical Activity with Accelerometry-Based Mean Amplitude Deviation (MAD.

    Directory of Open Access Journals (Sweden)

    Henri Vähä-Ypyä

    Full Text Available Our recent study of three accelerometer brands in various ambulatory activities showed that the mean amplitude deviation (MAD of the resultant acceleration signal performed best in separating different intensity levels and provided excellent agreement between the three devices. The objective of this study was to derive a regression model that estimates oxygen consumption (VO2 from MAD values and validate the MAD-based cut-points for light, moderate and vigorous locomotion against VO2 within a wide range of speeds.29 participants performed a pace-conducted non-stop test on a 200 m long indoor track. The initial speed was 0.6 m/s and it was increased by 0.4 m/s every 2.5 minutes until volitional exhaustion. The participants could freely decide whether they preferred to walk or run. During the test they carried a hip-mounted tri-axial accelerometer and mobile metabolic analyzer. The MAD was calculated from the raw acceleration data and compared to directly measured incident VO2. Cut-point between light and moderate activity was set to 3.0 metabolic equivalent (MET, 1 MET = 3.5 ml · kg-1 · min-1 and between moderate and vigorous activity to 6.0 MET as per standard use.The MAD and VO2 showed a very strong association. Within individuals, the range of r values was from 0.927 to 0.991 providing the mean r = 0.969. The optimal MAD cut-point for 3.0 MET was 91 mg (milligravity and 414 mg for 6.0 MET.The present study showed that the MAD is a valid method in terms of the VO2 within a wide range of ambulatory activities from slow walking to fast running. Being a device-independent trait, the MAD facilitates directly comparable, accurate results on the intensity of physical activity with all accelerometers providing tri-axial raw data.

  7. The Rhetoric of Madness in Kathy Acker’s Don Quixote

    Directory of Open Access Journals (Sweden)

    Claudia Cao

    2017-07-01

    Full Text Available This essay examines the rhetorical experimentation of Don Quixote by Kathy Acker, starting from a theoretical concept central in the author’s thought: her search for a “language of the body”. A brief introduction to Kathy Acker’s plagiaristic poetics frames her narrative strategies between postmodern rewriting and pastiche. It shows the way in which her Don Quixote transposes the representative scheme of the chivalric quest into the contemporary value system with the aim of questioning Cervantes’ text as one of the canonical works of the Western literary tradition. The following section deepens three focal concepts of Acker’s theoretical works – body, madness, and norm – illuminating the connections between her rhetorical experimentation and the works by Luce Irigaray and Judith Butler. Finally, the paper will demonstrate how these concepts in Acker's rewriting of Don Quixote are strictly related to paradox, which she uses in order to actualize a “language of the body”: in the passage from the former novel to the postmodern work, madness has become the device which, from the semantic level to the rhetorical one, expresses Acker’s idea of language of the body, as an alternative and in contrast to the canonical language of the logos.

  8. MadAnalysis Recast Code for Dark Matter Production in Association with Bottom Quarks

    CERN Document Server

    Biswas, Diptaparna

    The CMS-B2G-15-007 analysis was carried out to investigate the $pp\\rightarrow bb+DM$ process, which is a candidate process of direct Dark Matter production. In this particular work, this process is simulated and analyzed for 13 TeV LHC experiment using MadGraph, Pythia 8 and MadAnalysis C++ API. The recast code is written to reproduce the results obtained by the experimentalists in CMS-B2G-15-007 analysis. The result is interpreted within simplified scalar model in terms of the coupling between the mediator and the DM candidate and evaluated based on the MET distribution. CMS-B2G-15-007 uses a dataset of $2.17fb^{-1}$ of data collected by the CMS experiment in $\\sqrt{s}=13TeV$ proton-proton collisions at LHC. This analysis is sensitive also to DM production processes in association with top quarks. Results are reported as upper limits on the cross section for the b quark and top quark associated production independently, and interpreted within simplified models in terms of the coupling between the mediator an...

  9. TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching.

    Science.gov (United States)

    Ye, Qiaozhen; Rosenberg, Scott C; Moeller, Arne; Speir, Jeffrey A; Su, Tiffany Y; Corbett, Kevin D

    2015-04-28

    The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family. Here we present the structure of the Caenorhabditis elegans TRIP13 ortholog PCH-2, revealing a new family of AAA+ ATPase protein remodelers. PCH-2 possesses a substrate-recognition domain related to those of the protein remodelers NSF and p97, while its overall hexameric architecture and likely structural mechanism bear close similarities to the bacterial protein unfoldase ClpX. We find that TRIP13, aided by the adapter protein p31(comet), converts the HORMA-family spindle checkpoint protein MAD2 from a signaling-active 'closed' conformer to an inactive 'open' conformer. We propose that TRIP13 and p31(comet) collaborate to inactivate the spindle assembly checkpoint through MAD2 conformational conversion and disassembly of mitotic checkpoint complexes. A parallel HORMA protein disassembly activity likely underlies TRIP13's critical regulatory functions in meiotic chromosome structure and recombination.

  10. TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

    Energy Technology Data Exchange (ETDEWEB)

    Ye, Qiaozhen [Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, United States; Rosenberg, Scott C. [Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, United States; Moeller, Arne [National Resource for Automated Molecular Microscopy, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States; Speir, Jeffrey A. [National Resource for Automated Molecular Microscopy, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States; Su, Tiffany Y. [Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, United States; Corbett, Kevin D. [Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, United States; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States

    2015-04-28

    The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family. Here we present the structure of the Caenorhabditis elegans TRIP13 ortholog PCH-2, revealing a new family of AAA+ ATPase protein remodelers. PCH-2 possesses a substrate-recognition domain related to those of the protein remodelers NSF and p97, while its overall hexameric architecture and likely structural mechanism bear close similarities to the bacterial protein unfoldase ClpX. We find that TRIP13, aided by the adapter protein p31(comet), converts the HORMA-family spindle checkpoint protein MAD2 from a signaling-active ‘closed’ conformer to an inactive ‘open’ conformer. We propose that TRIP13 and p31(comet) collaborate to inactivate the spindle assembly checkpoint through MAD2 conformational conversion and disassembly of mitotic checkpoint complexes. A parallel HORMA protein disassembly activity likely underlies TRIP13's critical regulatory functions in meiotic chromosome structure and recombination.

  11. Proceedings of the fourth High-Energy Physics International Conference HEP-MAD 09

    International Nuclear Information System (INIS)

    Narison, S.

    2009-01-01

    This is the 4th of the series of HEP-MAD conference organized regularly every 2 or 3 years in Madagascar, in alternance to the traditional series of QCD-conference held in Montpellier (France) on July. The conference is expected to involve few numbers of physicists from abroad and equal numbers of experimental and theoretical high-energy physicists.Unlike the QCD conference which is a specialized meeting, HEP-MAD aims to have a wide view of physics: from High-Energy to Astro Physics. National contributions cover Nuclear and Environment Physics and the new form of energies (solar,...). This conference is a compromise between a standard one where specialized topics are presented and an introductory school to each subjects.It gives the opportunuity for high-energy physicists to promote the field of high-energy physics (theory and experiments)in Madagascar. In the same time, the meeting will permit to the participants to discover the country (well-known about its bio-diversity and rare animal and plant species) and its tradition and population from different origins.The theoretical and experimental talks cover different aspects of high-energy physics which are in the form of introductional reviews to the field, short contributions and posters. These talks are complemented by other national talks in other areas of physics. The Conference is expected to be published on-line by SLAC in a eConf-proceedings.

  12. Live and let die - the B(sister MADS-box gene OsMADS29 controls the degeneration of cells in maternal tissues during seed development of rice (Oryza sativa.

    Directory of Open Access Journals (Sweden)

    Xuelian Yang

    Full Text Available B(sister genes have been identified as the closest relatives of class B floral homeotic genes. Previous studies have shown that B(sister genes from eudicots are involved in cell differentiation during ovule and seed development. However, the complete function of B(sister genes in eudicots is masked by redundancy with other genes and little is known about the function of B(sister genes in monocots, and about the evolution of B(sister gene functions. Here we characterize OsMADS29, one of three MADS-box B(sister genes in rice. Our analyses show that OsMADS29 is expressed in female reproductive organs including the ovule, ovule vasculature, and the whole seed except for the outer layer cells of the pericarp. Knock-down of OsMADS29 by double-stranded RNA-mediated interference (RNAi results in shriveled and/or aborted seeds. Histological analyses of the abnormal seeds at 7 days after pollination (DAP indicate that the symplastic continuity, including the ovular vascular trace and the nucellar projection, which is the nutrient source for the filial tissue at early development stages, is affected. Moreover, degeneration of all the maternal tissues in the transgenic seeds, including the pericarp, ovular vascular trace, integuments, nucellar epidermis and nucellar projection, is blocked as compared to control plants. Our results suggest that OsMADS29 has important functions in seed development of rice by regulating cell degeneration of maternal tissues. Our findings provide important insights into the ancestral function of B(sister genes.

  13. An Atlas of Type I MADS Box Gene Expression during Female Gametophyte and Seed Development in Arabidopsis[W].

    NARCIS (Netherlands)

    Bemer, M.; Heijmans, K.; Airoldi, C.A.; Davies, B.; Angenent, G.C.

    2010-01-01

    Members of the plant type I MADS domain subfamily have been reported to be involved in reproductive development in Arabidopsis (Arabidopsis thaliana). However, from the 61 type I genes in the Arabidopsis genome, only PHERES1, AGAMOUS-LIKE80 (AGL80), DIANA, AGL62, and AGL23 have been functionally

  14. Towards an ESL design framework for adaptive and fault-tolerant MPSoCs: MADNESS or not?

    NARCIS (Netherlands)

    Cannella, E.; Di Gregorioi, L.; Fiorin, L.; Lindwer, M.; Meloni, P.; Neugebauer, O.; Pimentel, A.

    2011-01-01

    The MADNESS project aims at the definition of innovative system-level design methodologies for embedded MP-SoCs, extending the classic concept of design space exploration in multi-application domains to cope with high heterogeneity, technology scaling and system reliability. The main goal of the

  15. The contaminated Western Hero and other madness during the Atomic Age; Der verstrahlte Westernheld und anderer Irrsinn aus dem Atomzeitalter

    Energy Technology Data Exchange (ETDEWEB)

    Herzog, Rudolph

    2012-11-01

    The book on mad activities during the Atomic Age includes the following topics: The second most hazardous invention in all time; the red bomb; the story on the tactic nuclear war; the contaminated Western hero or how the bomb came to Alaska; swords into plowshares; the apocalypse machine; flying reactors; how safe is safe?; atomic Australia; nuclear medicine on wrong ways; broken arrows.

  16. Genetic and epigenetic alteration among three homoeologous genes of a class E MADS box gene in hexaploid wheat.

    Science.gov (United States)

    Shitsukawa, Naoki; Tahira, Chikako; Kassai, Ken-Ichiro; Hirabayashi, Chizuru; Shimizu, Tomoaki; Takumi, Shigeo; Mochida, Keiichi; Kawaura, Kanako; Ogihara, Yasunari; Murai, Koji

    2007-06-01

    Bread wheat (Triticum aestivum) is a hexaploid species with A, B, and D ancestral genomes. Most bread wheat genes are present in the genome as triplicated homoeologous genes (homoeologs) derived from the ancestral species. Here, we report that both genetic and epigenetic alterations have occurred in the homoeologs of a wheat class E MADS box gene. Two class E genes are identified in wheat, wheat SEPALLATA (WSEP) and wheat LEAFY HULL STERILE1 (WLHS1), which are homologs of Os MADS45 and Os MADS1 in rice (Oryza sativa), respectively. The three wheat homoeologs of WSEP showed similar genomic structures and expression profiles. By contrast, the three homoeologs of WLHS1 showed genetic and epigenetic alterations. The A genome WLHS1 homoeolog (WLHS1-A) had a structural alteration that contained a large novel sequence in place of the K domain sequence. A yeast two-hybrid analysis and a transgenic experiment indicated that the WLHS1-A protein had no apparent function. The B and D genome homoeologs, WLHS1-B and WLHS1-D, respectively, had an intact MADS box gene structure, but WLHS1-B was predominantly silenced by cytosine methylation. Consequently, of the three WLHS1 homoeologs, only WLHS1-D functions in hexaploid wheat. This is a situation where three homoeologs are differentially regulated by genetic and epigenetic mechanisms.

  17. Evaluation d'une approche pedagogique respectant les facons d'apprendre des filles en sciences et en TIC en 9e annee au Nouveau-Brunswick

    Science.gov (United States)

    Lirette-Pitre, Nicole T.

    2009-07-01

    La reussite scolaire des filles les amene de plus en plus a poursuivre une formation postsecondaire et a exercer des professions qui demandent un haut niveau de connaissances et d'expertise scientifique. Toutefois, les filles demeurent toujours tres peu nombreuses a envisager une carriere en sciences (chimie et physique), en ingenierie ou en TIC (technologie d'information et de la communication), soit une carriere reliee a la nouvelle economie. Pour plusieurs filles, les sciences et les TIC ne sont pas des matieres scolaires qu'elles trouvent interessantes meme si elles y reussissent tres bien. Ces filles admettent que leurs experiences d'apprentissage en sciences et en TIC ne leur ont pas permis de developper un interet ni de se sentir confiante en leurs habiletes a reussir dans ces matieres. Par consequent, peu de filles choisissent de poursuivre leurs etudes postsecondaires dans ces disciplines. La theorie sociocognitive du choix carriere a ete choisie comme modele theorique pour mieux comprendre quelles variables entrent en jeu lorsque les filles choisissent leur carriere. Notre etude a pour objet la conception et l'evaluation de l'efficacite d'un materiel pedagogique concu specifiquement pour ameliorer les experiences d'apprentissage en sciences et en TIC des filles de 9e annee au Nouveau-Brunswick. L'approche pedagogique privilegiee dans notre materiel a mis en oeuvre des strategies pedagogiques issues des meilleures pratiques que nous avons identifiees et qui visaient particulierement l'augmentation du sentiment d'auto-efficacite et de l'interet des filles pour ces disciplines. Ce materiel disponible par Internet a l'adresse http://www.umoncton.ca/lirettn/scientic est directement en lien avec le programme d'etudes en sciences de la nature de 9e annee du Nouveau-Brunswick. L'evaluation de l'efficacite de notre materiel pedagogique a ete faite selon deux grandes etapes methodologiques: 1) l'evaluation de l'utilisabilite et de la convivialite du materiel et 2

  18. Silvicultural madness

    DEFF Research Database (Denmark)

    Basnyat, Bijendra; Treue, Thorsten; Pokharel, R.K.

    2018-01-01

    Following a case study approach, this paper explains how scientific forest management plans were developed and implemented in community forests of a mid-hill district in Nepal. Field observations were carried over a period of two years (December 2014 to December 2016) in two community forests. User...... guidelines with little reference to the actual site quality, management objectives, and forest stand conditions. Apart from harvesting of trees, users hardly implemented the plans‘ silvicultural prescriptions and forest restoration activities. Moreover forest officials administratively reduced the number...... of trees that users could harvest to around half of what the plans allow. Accordingly, forest user groups face a paradoxical forest administration that promotes timber harvesting according to so-called scientific principles, which it then brushes aside to satisfy bureaucratic demands. The study concludes...

  19. Mascot Madness

    Science.gov (United States)

    Henderson, Nancy

    2013-01-01

    For institutions around the world, mascots serve many purposes, such as raising school spirit and energizing sports teams. But mascots also can breed discord. In recent decades, some schools have been challenged to replace controversial Native American mascots while others have encountered resistance when introducing different mascot designs.…

  20. MADS specificity

    NARCIS (Netherlands)

    Mourik, van Hilda

    2017-01-01

    Encrypted in the DNA lays most information needed for the development of an organism. The transcription of this information into precise patterns of gene activity results in the development of different cell types, organs, and developmental structures. Moreover, transcriptional regulation enables

  1. El concepto de locura en la obra de Jacques Lacan The Concept Of Madness In The Jacques Lacan Work's

    Directory of Open Access Journals (Sweden)

    Pablo D. Muñoz

    2008-12-01

    Full Text Available Desde sus primeros escritos Lacan distingue el concepto de locura del de psicosis, contradiciendo el uso común que los toma como equivalentes. Esta confusión produce efectos en la clínica psicoanalítica, por lo cual conviene aclarar y mantener su diferencia. Si bien los comentadores de su obra han reconocido esa distinción, no se ha destacado todo lo necesario la transformación que sufre el concepto de locura al final de la misma, ni se ha establecido con precisión su índole, sus alcances y consecuencias. Para hacerlo se propone explorar las diferencias entre locura y psicosis con el recurso de la teoría de nudos que Lacan emplea en dicho período, donde la psicosis es formalizada como una forma particular de anudamiento de los registros distinto del de la neurosis y la locura como su desanudamiento. En este trabajo se realiza un recorrido que enlaza las primeras referencias de Lacan sobre la locura con las recién mencionadas.First Lacan writings differentiates the "madness" concept from the other one of "psychosis", contradicting therefore the common use in language that takes them equivalent. This confusion can carry adverse effects in the psychoanalytic clinic. Thus is better to clarify and maintain its difference. Although Lacan comentators have recognized that distinction is not enough outstanded the transformation of the concept of "madness" at the his latest works, nor has settled down its nature, its reaches and consequences. In order to do it, we will explore the differences between "madness" and "psychosis" with his knots theory support, where the psychosis and neurosis like particular different form of knotting, and also defines "madness" like a registers untied. In this work is carried out a journey that connects the first references of Lacan about the madness with the last ones mentioned.

  2. Accurate Numerical Simulations Of Chemical Phenomena Involved in Energy Production and Storage with MADNESS and MPQC: ALCF-2 Early Science Program Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Vzquez-Mayagoitia, Alvaro [Argonne National Lab. (ANL), Argonne, IL (United States); Hammond, Jeff R. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2013-09-16

    In order to solve the electronic structure of large molecular systems on petascale computers using MADNESS, a numerical tool kit, are required fast and accurate implementations for linear algebra. MADNESS uses multiresolution analysis and low separation rank which translates high dimensional functions in tensor products using Legendre polynomial. The multiple tensor products make to the singular value decomposition and matrix multiplication the most intense operations in MADNESS. This work discusses the interfacing of Eigen3 as a C++ substitute of LAPACK and introduces Elemental for the diagonalization of large matrices. Furthermore, the present paper shows the performance these libraries on Blue Gene/ Q.

  3. A perspective of Middle-Atmosphere Dynamics (MAD) studies at the New International Equatorial Observatory (NIEO)

    Science.gov (United States)

    Yamanaka, M. D.; Fukao, S.

    1989-01-01

    The equatorial region has attracted many MAD studies mainly based on data of limited locations and resolutions. Established at NIEO are: (1) Climatology of the equatorial middle atmosphere (all of the mean zonal flow, the meridional and/or east-west circulations and the planetary/gravity waves are described based on massive, reliable data statistics); (2) Troposphere-stratosphere coupling at the equator (the candidate location of NIEO is just at the stratospheric fountain area where the tracers and waves are pumped up into the middle atmosphere); and (3) Mesosphere-thermosphere coupling at the equator; thermospheric superrotation, which may be caused either by ion drag or by tidal breaking, is examined in detail by observations covering a wide altitude range from the mesosphere through the thermosphere.

  4. MADNESS applied to density functional theory in chemistry and nuclear physics

    International Nuclear Information System (INIS)

    Fann, G I; Harrison, R J; Beylkin, G; Jia, J; Hartman-Baker, R; Shelton, W A; Sugiki, S

    2007-01-01

    We describe some recent mathematical results in constructing computational methods that lead to the development of fast and accurate multiresolution numerical methods for solving quantum chemistry and nuclear physics problems based on Density Functional Theory (DFT). Using low separation rank representations of functions and operators in conjunction with representations in multiwavelet bases, we developed a multiscale solution method for integral and differential equations and integral transforms. The Poisson equation, the Schrodinger equation, and the projector on the divergence free functions provide important examples with a wide range of applications in computational chemistry, nuclear physics, computational electromagnetic and fluid dynamics. We have implemented this approach along with adaptive representations of operators and functions in the multiwavelet basis and low separation rank (LSR) approximation of operators and functions. These methods have been realized and implemented in a software package called Multiresolution Adaptive Numerical Evaluation for Scientific Simulation (MADNESS)

  5. Mad Colonial Narrators in Anglo-Irish Literature: Lemuel Gulliver and Freddie Montgomery

    Directory of Open Access Journals (Sweden)

    Patricia Jones

    2018-03-01

    Full Text Available The following discussion highlights parallels between the narrators, Lemuel Gulliver of Jonathan Swift’s Gulliver’s Travels (1726 and Freddie Montgomery of John Banville’s The Book of Evidence (1989. The argument calls on post-colonialism, Foucaultian theory of “will to truth” and the narrative theory of Shlomith Rimmon-Kenan to emphasize similarities in the rendering of mental degeneration in Gulliver and Montgomery. The colonial-induced mental breakdown of both narrators can be said to unravel, not so much in the tale these narrators think they are relating, but instead between the lines of their stories in narratives which continually focus attention back onto themselves. Despite the 260 years separating these works, the madness of both Gulliver and Montgomery can be interpreted as a reluctance on their respective parts to shed established colonial identities once the colonial stage has receded.

  6. Portfolio optimization using Mean Absolute Deviation (MAD and Conditional Value-at-Risk (CVaR

    Directory of Open Access Journals (Sweden)

    Lucas Pelegrin da Silva

    Full Text Available Abstract This paper investigates the efficiency of traditional portfolio optimization models when the returns of financial assets are highly volatile, e.g., in financial crises periods. We also develop alternative optimization models that combine the mean absolute deviation (MAD and the conditional value at risk (CVaR, attempting to mitigate inefficient, low return and/or high-risk, portfolios. Three methodologies for estimating the probability of the asset’s historical returns are also compared. By using historical data on the Brazilian stock market between 2004 and 2013, we analyze the efficiency of the proposed approaches. Our results show that the traditional models provide portfolios with higher returns, but our propose model are able to generate lower risk portfolios, which might be more attractive in volatile markets. In addition, we find that models that do not use equiprobable scenarios produce better results in terms of return and risk.

  7. From morality to madness: a reappraisal of the asylum movement in psychiatry 1800-1940.

    Science.gov (United States)

    Kosky, R

    1986-06-01

    This essay outlines the history of the asylum movement in psychiatry, but from a somewhat different angle than usual. It attempts to delineate the historical interactions between perceptions of morality and of madness. Changes in these interactions relate to the rise of the asylum movement, around 1800, and its demise, just after World War II. I argue that, whilst insanity was defined against the rational, secular morality of the eighteenth century, it could be separated from immorality and put aside into its asylum. Once mechanistic science and medical scientism began, during the nineteenth century, to include immorality in the systems of disease, the distinction could not hold. The asylums became flooded with the immoral, and management became custodial and nihilistic. This nexus was broken when the asylums were defined, by a few revolutionary superintendents, as instruments of social control. Nevertheless, intellectual paradigms derived from asylum psychiatry persist.

  8. The Overestimation Phenomenon in a Skill-Based Gaming Context: The Case of March Madness Pools.

    Science.gov (United States)

    Kwak, Dae Hee

    2016-03-01

    Over 100 million people are estimated to take part in the NCAA Men's Basketball Tournament Championship bracket contests. However, relatively little is known about consumer behavior in skill-based gaming situations (e.g., sports betting). In two studies, we investigated the overestimation phenomenon in the "March Madness" context. In Study 1 (N = 81), we found that individuals who were allowed to make their own predictions were significantly more optimistic about their performance than individuals who did not make their own selections. In Study 2 (N = 197), all subjects participated in a mock competitive bracket pool. In line with the illusion of control theory, results showed that higher self-ratings of probability of winning significantly increased maximum willingness to wager but did not improve actual performance. Lastly, perceptions of high probability of winning significantly contributed to consumers' enjoyment and willingness to participate in a bracket pool in the future.

  9. From "Downton Abbey" to "Mad Men": TV series as the privileged format for transition eras

    Directory of Open Access Journals (Sweden)

    Marie Maillos

    2016-06-01

    Full Text Available On each side of the Atlantic, the Downton Abbey and Mad Men shows have contributed to the transformation of the period drama genre on television: instead of being set in a single precise era, they take place over periods of historical transition, genuine intervals that are full of contrasts and confrontations and even propel the narrative forward. This new approach to time periods results as much from the TV series format as from its mass medium nature: on the one hand, these shows use the apparent invariability required by the serial form to reveal by contrast the transition at work and provide the narrative with the necessary conflict; on the other hand, through their depictions of transitional eras, they offer a commentary on our contemporary period, a characteristic device of television series. Therefore, both shows, notwithstanding their differences in themes, locations and craftmanship, play a part in making the transition period drama become a serial genre in its own right.

  10. New features of MadAnalysis 5 for analysis design and reinterpretation

    CERN Document Server

    Conte, Eric; Fuks, Benjamin; Schmitt, Thibaut

    2015-01-01

    We present MadAnalysis 5, an analysis package dedicated to phenomenological studies of simulated collisions occurring in high-energy physics experiments. Within this framework, users are invited, through a user-friendly Python interpreter, to implement physics analyses in a very simple manner. A C++ code is then automatically generated, compiled and executed. Very recently, the expert mode of the program has been extended so that analyses with multiple signal/control regions can be handled. Additional observables have also been included, and an interface to several fast detector simulation packages has been developed, one of them being a tune of the Delphes 3 software. As a result, a recasting of existing ATLAS and CMS analyses can be achieved straightforwardly.

  11. Women at Home and Women in the Workplace in Matthew Weiner´s "Mad Men"

    Directory of Open Access Journals (Sweden)

    Susana Sánchez Renieblas

    2013-01-01

    Full Text Available Matthew Weiner´s successful American TV series, Mad Men (2007, set in the 1960s in New York, unmasks the private and the public spaces of the home and the office. In these spaces, not only do the masculine protagonists interact, but also several feminine characters do as well. The three female characters (Betty, Peggy and Joan, who will be analyzed, represent the female stereotypes of this period: the idyllic housewife, the Sandra Dee prototype and the bombshell Marilyn Monroe archetype. In comparing the private and public spaces of the home and the office, these women´s sexuality and submission will be affected and influenced by the spaces they inhabit.

  12. Mad Speculation and Absolute Inhumanism: Lovecraft, Ligotti, and the Weirding of Philosophy

    Directory of Open Access Journals (Sweden)

    Ben Woodard

    2011-03-01

    Full Text Available I want to propose, as a trajectory into the philosophically weird, an absurd theoretical claim and pursue it, or perhaps more accurately, construct it as I point to it, collecting the ground work behind me like the Perpetual Train from China Mieville's Iron Council which puts down track as it moves reclaiming it along the way. The strange trajectory is the following: Kant's critical philosophy and much of continental philosophy which has followed, has been a defense against horror and madness. Kant's prohibition on speculative metaphysics such as dogmatic metaphysics and transcendental realism, on thinking beyond the imposition of transcendental and moral constraints, has been challenged by numerous figures proceeding him.

  13. Philippe Pinel's "Memoir on Madness" of December 11, 1794: a fundamental text of modern psychiatry.

    Science.gov (United States)

    Weiner, D B

    1992-06-01

    Philippe Pinel's "Memoir on Madness" can now be precisely dated. It was read to the Society for Natural History in Paris on Dec. 11, 1794, soon after the fall of the Jacobin dictatorship. It is thus a political document, an appeal to the Revolutionary government to build asylums where the mentally ill could be decently treated. It is translated here for the first time. Philippe Pinel (1745-1826) served as "physician of the infirmaries" at Bicêtre, the public hospice for men near Paris, from 1793 to 1795. In the "Memoir on Madness" he explains his "psychologic treatment," the principles of the humane method that made him the founder of psychiatry in France. Pinel states that mental illness is often curable. To arrive at a diagnosis, the physician must carefully observe a patient's behavior, interview him, listen carefully, and take notes. He must understand the natural history of the disease and the precipitating event and write an accurate case history. Diagnosis and prognosis can then be made. Periodic patterns of mental illness can be helpful for therapy. Usually only one faculty is affected. Patients with delusions may be malicious or murderous. They may have to be restrained; it was Pinel's assistant, Jean Baptiste Pussin, who removed the chains from the insane men at Bicêtre Hospice in 1797 and replaced them with strait-jackets. Pinel followed suit at the Salpêtrière, the public hospice for women, 3 years later. Pinel here states that one must "dominate agitated madmen while respecting human rights."

  14. La locura y sus versiones en la obra de J. Lacan II: locura y psicosis The madness and his versions in the J. Lacan work's II: madness and psychosis

    Directory of Open Access Journals (Sweden)

    Pablo D. Muñoz

    2010-12-01

    Full Text Available Este trabajo presenta parte de las conclusiones del proyecto de investigación UBACyT P601: "Variaciones del concepto de locura en la obra de J. Lacan. Su incidencia en el diagnóstico diferencial neurosis-psicosis", aprobado y financiado para el período 2008-2010. Se aborda especialmente la cuestión problemática de su delimitación conceptual en la obra de Lacan, en la cual el término locura es empleado de diversos modos. Esta variedad se plasma en su articulación con distintos conceptos y con problemas clínicos de diversa índole. La presentación conjunta de estos usos permite obtener una visión bastante amplia de las ventajas que trae servirse de alguna de las versiones de la locura que se presentan en la obra de Lacan. En este trabajo se aplican a la articulación locura-psicosis, abordando no sólo la problemática conceptual en juego en lo atinente a alcanzar una definición más precisa de "locura", sino sobre todo el agudo problema clínico que presentan lo que podríamos designar "psicosis enloquecidas".This paper presents some of the conclusions of the research project UBACyT P601: "Variations of the concept of madness in the work of J. Lacan. Its incidence in the differential diagnosis neurosis psychosis ", approved and funded for the period 2008-2010. It especially addresses the problematic issue of its conceptual delimitation in the Lacan work, in which the term "madness" is used in several senses. This variety is reflected in its theoretical concept articulation and several clinical issues. The whole presentation of these work allows a wider vision of the benefits that brings to use any of the versions of "madness" concept that arise in the work of Lacan. This work apply to the madness-psychosis articulation, addressing not only the conceptual issues, but also achieving a more precise definition of "madness"; and above of all it takes the big clinical problem in what we might call "mad psychosis".

  15. La locura y sus versiones en la obra de J. Lacan: I: locura y neurosis The madness and his versions in the J. Lacan work's: I: madness and neurosis

    Directory of Open Access Journals (Sweden)

    Pablo D. Muñoz

    2010-12-01

    Full Text Available Este trabajo presenta parte de las conclusiones del proyecto de investigación UBACyT P601: "Variaciones del concepto de locura en la obra de J. Lacan. Su incidencia en el diagnóstico diferencial neurosis-psicosis", aprobado y financiado para el período 2008-2010. Se aborda especialmente la cuestión problemática de su delimitación conceptual en la obra de Lacan, en la cual el término locura es empleado de diversos modos. Esta variedad se plasma en su articulación con distintos conceptos y con problemas clínicos de diversa índole. La presentación conjunta de estos usos permite obtener una visión bastante amplia de las ventajas que trae servirse de alguna de las versiones de la locura que se presentan en la obra de Lacan. En este trabajo se aplican a la articulación locura-neurosis, abordando no sólo la problemática conceptual en juego en lo atinente a alcanzar una definición más precisa de "locura", sino sobre todo el agudo problema clínico que presentan lo que podríamos designar "neurosis enloquecidas".This paper presents some of the conclusions of the research project UBACyT P601: "Variations of the concept of madness in the work of J. Lacan. Its incidence in the differential diagnosis neurosis psychosis ", approved and funded for the period 2008-2010. It especially addresses the problematic issue of its conceptual delimitation in the Lacan work, in which the term "madness" is used in several senses. This variety is reflected in its theoretical concept articulation and several clinical issues. The whole presentation of these work allows a wider vision of the benefits that brings to use any of the versions of "madness" concept that arise in the work of Lacan. This work apply to the madness-neurosis articulation, addressing not only the conceptual issues, but also achieving a more precise definition of "madness"; and above of all it takes the big clinical problem in what we might call "mad neurosis".

  16. Périodiques scientifiques Les usagers du CERN entre passage au tout électronique et nouveau modèle de publication

    CERN Document Server

    Bessero, C

    2008-01-01

    Les usagers de la bibliothèque du CERN (Organisation européenne pour la recherche nucléaire) représentent près de la moitié des physiciens des hautes énergies à travers le monde. Les spécificités de cette communauté expliquent sa rapide adoption du format électronique pour l'organisation de sa communication scientifique ; elles permettent également de comprendre l'émergence d'un nouveau modèle de publication en libre accès conçu à son intention. La bibliothèque se révèle être un partenaire indispensable à ces changements, notamment en raison de la constitution d'une collection complémentaire, adaptée à des besoins pointus et diversifiés dans les domaines connexes à la physique des hautes énergies.

  17. Discrimination of solvent from protein regions in native Fouriers as a means of evaluating heavy-atom solutions in the MIR and MAD methods

    International Nuclear Information System (INIS)

    Terwilliger, Thomas C.; Berendzen, Joel

    1999-01-01

    The presence of distinct regions of high and low density variation in electron-density maps is found to be a good indicator of the correctness of a heavy-atom solution in the MIR and MAD methods. An automated examination of the native Fourier is tested as a means of evaluation of a heavy-atom solution in MAD and MIR methods for macromolecular crystallography. It is found that the presence of distinct regions of high and low density variation in electron-density maps is a good indicator of the correctness of a heavy-atom solution in the MIR and MAD methods. The method can be used to evaluate heavy-atom solutions during MAD and MIR structure solutions and to determine the handedness of the structure if anomalous data have been measured

  18. “You can’t be a man. Be a woman, it’s a powerful business when done correctly”:women and work in Mad Men

    OpenAIRE

    Korhonen, M. (Maria)

    2016-01-01

    Abstract The topic of this thesis pertains to how female characters are portrayed in the American period drama TV series Mad Men (2007–2015) that is set in the 1960s, and the main focus is on Margaret ‘Peggy’ Olson, who works as a copywriter at the fictional advertising agency Sterling Cooper. This thesis focuses on three main themes through which Peggy Olson’s journey in Mad Men are analyzed: appearance, obstacles in the w...

  19. Wind power; L'energie eolienne

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-06-15

    This road-map proposes by the Group Total aims to inform the public on the wind power. It presents the principles, the technology takes off, its applications and technology focus, the global market trends and the outlooks and Total commitments in the domain. (A.L.B.)

  20. MadR1, a Mycobacterium tuberculosis cell cycle stress response protein that is a member of a widely conserved protein class of prokaryotic, eukaryotic and archeal origin.

    Science.gov (United States)

    Crew, Rebecca; Ramirez, Melissa V; England, Kathleen; Slayden, Richard A

    2015-05-01

    Stress-induced molecular programs designed to stall division progression are nearly ubiquitous in bacteria, with one well-known example being the participation of the SulA septum inhibiting protein in the SOS DNA damage repair response. Mycobacteria similarly demonstrate stress-altered growth kinetics, however no such regulators have been found in these organisms. We therefore set out to identify SulA-like regulatory proteins in Mycobacterium tuberculosis. A bioinformatics modeling-based approach led to the identification of rv2216 as encoding for a protein with weak similarity to SulA, further analysis distinguished this protein as belonging to a group of uncharacterized growth promoting proteins. We have named the mycobacterial protein encoded by rv2216 morphology altering division regulator protein 1, MadR1. Overexpression of madR1 modulated cell length while maintaining growth kinetics similar to wild-type, and increased the proportion of bent or V-form cells in the population. The presence of MadR1-GFP at regions of cellular elongation (poles) and morphological differentiation (V-form) suggests MadR1 involvement in phenotypic heterogeneity and longitudinal cellular growth. Global transcriptional analysis indicated that MadR1 functionality is linked to lipid editing programs required for growth and persistence. This is the first report to differentiate the larger class of these conserved proteins from SulA proteins and characterizes MadR1 effects on the mycobacterial cell. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. Closure Report for Corrective Action Unit 254: Area 25, R-MAD Decontamination Facility, Nevada Test Site, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    G. N. Doyle

    2002-02-01

    Corrective Action Unit (CAU) 254 is located in Area 25 of the Nevada Test Site (NTS), approximately 100 kilometers (km) (62 miles) northwest of Las Vegas, Nevada. The site is located within the Reactor Maintenance, Assembly and Disassembly (R-MAD) compound and consists of Building 3126, two outdoor decontamination pads, and surrounding areas within an existing fenced area measuring approximately 50 x 37 meters (160 x 120 feet). The site was used from the early 1960s to the early 1970s as part of the Nuclear Rocket Development Station program to decontaminate test-car hardware and tooling. The site was reactivated in the early 1980s to decontaminate a radiologically contaminated military tank. This Closure Report (CR) describes the closure activities performed to allow un-restricted release of the R-MAD Decontamination Facility.

  2. MAdCAM-1 is needed for diabetes development mediated by the T cell clone, BDC-2·5

    Science.gov (United States)

    Phillips, Jenny M; Haskins, Kathryn; Cooke, Anne

    2005-01-01

    The NOD-derived islet-reactive CD4+ T cell clone, BDC-2·5, is able to transfer diabetes to neonatal non-obese diabetic (NOD) mice but is unable to transfer disease to either adult NOD or NOD scid recipients. Transfer of diabetes to adult recipients by BDC-2·5 is only accomplished by cotransfer of CD8+ T cells from a diabetic donor. To understand why this CD4+ T cell clone is able to mediate diabetes in neonatal but not the adult recipients we examined the ability of the clone to traffic in the different recipients. Our studies showed that MAdCAM-1 has a very different expression pattern in the neonatal and adult pancreas. Blockade of this addressin prevents the clone from transferring diabetes to neonatal mice, suggesting that the differential pancreatic expression of MAdCAM-1 in neonatal and adult pancreas provides an explanation of the differences in diabetes development. PMID:16313366

  3. Constructed identities A Chronotopic reading of The Great Gatsby, The Man in the Gray Flannel Suit, and Mad Men

    OpenAIRE

    Yndestad, Ingrid Rivedal

    2016-01-01

    This thesis aims to explore how the past figures in F. Scott Fitzgerald's The Great Gatsby (1925), Sloan Wilson's The Man in the Gray Flannel Suit (1955), and in the AMC series Mad Men (2007-2015), written by Matthew Weiner. Focusing on the main protagonists in these works, namely Jay Gatsby, Thomas Rath, and Donald Draper, this thesis examines how the past makes itself valid in these characters' present lives and how it arguably affects their future lives. In do...

  4. Novel complex MAD phasing and RNase H structural insights using selenium oligonucleotides

    Energy Technology Data Exchange (ETDEWEB)

    Abdur, Rob; Gerlits, Oksana O.; Gan, Jianhua; Jiang, Jiansheng; Salon, Jozef; Kovalevsky, Andrey Y.; Chumanevich, Alexander A.; Weber, Irene T.; Huang, Zhen, E-mail: huang@gsu.edu [Georgia State University, Atlanta, GA 30303 (United States)

    2014-02-01

    Selenium-derivatized oligonucleotides may facilitate phase determination and high-resolution structure determination for protein–nucleic acid crystallography. The Se atom-specific mutagenesis (SAM) strategy may also enhance the study of nuclease catalysis. The crystal structures of protein–nucleic acid complexes are commonly determined using selenium-derivatized proteins via MAD or SAD phasing. Here, the first protein–nucleic acid complex structure determined using selenium-derivatized nucleic acids is reported. The RNase H–RNA/DNA complex is used as an example to demonstrate the proof of principle. The high-resolution crystal structure indicates that this selenium replacement results in a local subtle unwinding of the RNA/DNA substrate duplex, thereby shifting the RNA scissile phosphate closer to the transition state of the enzyme-catalyzed reaction. It was also observed that the scissile phosphate forms a hydrogen bond to the water nucleophile and helps to position the water molecule in the structure. Consistently, it was discovered that the substitution of a single O atom by a Se atom in a guide DNA sequence can largely accelerate RNase H catalysis. These structural and catalytic studies shed new light on the guide-dependent RNA cleavage.

  5. Mad Cows and CJD A Physicist's View of Prion Brain Diseases

    CERN Document Server

    Morrison, Douglas Robert Ogston

    1997-01-01

    The research of Carleton Gajdusek on a stone-age tribe in Papua New Guinea, who suffered from a mysterious disease, kuru, spread by cannibalism, is described and short extracts from his films will be shown. Some deaths from kuru are still occuring after 45 years. This disease is believed to be caused by an entirely new mechanism, not a virus or bacteria, but by a small molecule known as a prion that occurs naturally in many living forms. The Prion Only hypothesis of Stan Prusiner is discussed critically. It has been calculated that 900,000 cows in Britain had the Mad Cow disease, BSE, but most were slaughtered before symptoms were recognised. This epidemic started with 10 cases in the first year, and finally 160,000 were officially classified as having BSE; it is now slowly dying out. The human epidemic, caused by a new version of Creutzfeldt-Jakob Disease, nvCJD, affects mainly young people, has just begun with 10 cases in the first year. The average incubation time may be about 14 years then death follows i...

  6. Method and Madness: An Analysis of Edgar Allan Poe's “The Bells”

    Directory of Open Access Journals (Sweden)

    U. Marie Engemann

    2017-11-01

    Full Text Available In this article, U. Marie Engemann has tried to indicate the method and internal cohesion of “The Bells”: a poem by Edgar Allan Poe, regardless of its apparent madness. This poem consists of four stanzas each of which is a symbol of a stage in the human's life for which a specific bell has been dedicated to. This poem follows trochaic meter in which the poet ingeniously has used catalexis in order to imitate the chime of bells. Throughout the poem, he has used different sound devices such as rhyme, sound patterning, alliteration, and onomatopoeia to create parallelism, and accordingly, he has conformed the chime of the bells to the dominant feature of each stage of life; thus, a meaningful cohesion has been created. This article can show how a poet may use different sound devices of his own language to create a parallelism between sound symbolism and meaning. The structure of the article has been changed a little by inserting the figures and the tables in the appendices into its straight text in translation so that it becomes easier for the readers to make a link between discussions and the data presented in each figure or table.

  7. Perspectives on MADS-box expression during orchid flower evolution and development.

    Science.gov (United States)

    Mondragón-Palomino, Mariana

    2013-01-01

    The diverse morphology of orchid flowers and their complex, often deceptive strategies to become pollinated have fascinated researchers for a long time. However, it was not until the 20th century that the ontogeny of orchid flowers, the genetic basis of their morphology and the complex phylogeny of Orchidaceae were investigated. In parallel, the improvement of techniques for in vitro seed germination and tissue culture, together with studies on biochemistry, physiology, and cytology supported the progress of what is now a highly productive industry of orchid breeding and propagation. In the present century both basic research in orchid flower evo-devo and the interest for generating novel horticultural varieties have driven the characterization of many members of the MADS-box family encoding key regulators of flower development. This perspective summarizes the picture emerging from these studies and discusses the advantages and limitations of the comparative strategy employed so far. I address the growing role of natural and horticultural mutants in these studies and the emergence of several model species in orchid evo-devo and genomics. In this context, I make a plea for an increasingly integrative approach.

  8. Perspectives on MADS-box expression during orchid flower evolution and development

    Directory of Open Access Journals (Sweden)

    Mariana eMondragón Palomino

    2013-09-01

    Full Text Available The diverse morphology of orchid flowers and their complex, often deceptive strategies to become pollinated have fascinated researchers for a long time. However, it was not until the 20th century that the ontogeny of orchid flowers, the genetic basis of their morphology and the complex phylogeny of Orchidaceae were investigated. In parallel, the improvement of techniques for in vitro seed germination and tissue culture, together with studies on biochemistry, physiology and cytology supported the progress of what is now a highly productive industry of orchid breeding and propagation. In the present century both basic research in orchid flower evo-devo and the interest for generating novel horticultural varieties have driven the characterization of many members of the MADS-box family encoding key regulators of flower development. This perspective summarizes the picture emerging from these studies and discusses the advantages and limitations of the comparative strategy employed so far. I address the growing role of natural and horticultural mutants in these studies and the emergence of several model species in orchid evo-devo and genomics. In this context, I make a plea for an increasingly integrative approach.

  9. Voyage au cœur d’un futur inconnu : analyse du genre dans le cinéma de science-fiction chinois du nouveau millénaire

    OpenAIRE

    Yang, Wei

    2017-01-01

    Cet article étudie le cinéma de science-fiction comme nouveau genre du cinéma chinois. Tout en empruntant largement à son équivalent hollywoodien – costumes, décor, intrigue, caractérisation, effets visuels, et ainsi de suite – le cinéma de science-fiction chinois met rarement en scène les conceptions ou explorations scientifiques qui ont marqué un grand nombre de films de science-fiction ambitieux en Occident. En partie à cause du monopole hollywoodien du genre, les films de science-fiction ...

  10. Etude expérimentale sur le comportement d’un nouveau type d’accumulateur d’énergie thermique. Déterminations préliminaires sur l’installation expérimentale

    Directory of Open Access Journals (Sweden)

    Valentin Pavel

    2004-01-01

    Full Text Available On présente la première partie d’une étude concernant le comportement d’un nouveau type d’accumulateur d’énergie thermique. Sont présentées les déterminations se référant au comportement de l’unité centrale de stockage dans la phase de relaxation (refroidissement libre afin d’établir les pertes de chaleur, pour avoir une approche correcte des phénomènes dans les étapes ultérieures des études concernant l’accumulateur.

  11. Les conjonctivites néonatales dans le canton de Glidji au Sud du Togo: une étude transversale à propos de 159 nouveau-nés

    Science.gov (United States)

    Kokou, Vonor; Nidain, Maneh; Kassoula, Nononsaa Batomguela; Kwassi, Fiaty- Amenouvor; Meba, Banla; Patrice, Balo Komi

    2016-01-01

    Introduction Le but de l’étude était décrire les aspects épidémiologiques des conjonctivites néonatales dans le canton de Glidji au Sud du Togo. Methodes Nous avons mené une étude transversale dans les 4 Unités Sanitaires Périphériques du canton de Glidji du 19 Mars au 13 Mai 2009 soit 8 semaines. Tous les nouveau-nés ont été inclus et la conjonctivite néonatale était définie par la présence chez un nouveau-né d'au moins deux des signes suivants: hyperhémie conjonctivale, œdème palpébral, chémosis, sécrétions purulentes, larmoiement. Les paramètres étudiés étaient l’âge, le sexe, les facteurs de risque, les antécédents, la présence ou non de conjonctivite, les germes en causes et l’évolution sous traitement. Resultats Sur la période, 159 nouveau-nés ont été examinés. L’âge moyen était de 10,9 jours avec des extrêmes de 0 à 28 jours. Il y avait 80 garçons pour 79 filles soit un sex-ratio de 1,01. Sur les 159 nouveau-nés, 7 cas de conjonctivite ont été diagnostiqués soit une prévalence de 4,4%. Les facteurs de risque identifiés étaient l'accouchement par voie basse et la présence d'IST chez la mère pendant la grossesse. Sur les 7 cas de conjonctivite, l'examen cytobactériologique a permis d'isoler le staphylococcus aureus dans 2 cas. L’évolution des cas de conjonctivite sous traitement était favorable avec régression des signes dès le 3è jour. Conclusion Les conjonctivites néonatales avaient une prévalence de 4,4% dans le canton de Glidji au sud du Togo et le staphylocoque doré était le germe en cause. Leur prévention passe par un bon suivi lors de la consultation prénatale et l'instillation de collyre antibiotique à la naissance PMID:27642383

  12. Proyecciones Vintage: Mad Men y Cuéntame cómo pasó / Vintage Projections: Mad Men and Cuéntame cómo pasó

    Directory of Open Access Journals (Sweden)

    Laura García Pousa

    2016-09-01

    Full Text Available Las series de televisión han puesto a prueba la capacitación del drama mediante la construcción de un discurso propio y diferenciado, que las convierte en uno de los referentes artísticos contemporáneos de mayor expansión. En este artículo acudimos a su estudio específico como nuevos artefactos culturales que trabajan con múltiples realidades y niveles narrativos creando ficciones capaces de aglutinar éxito comercial y nuevas parcelas audiovisuales que generan reflexiones sobre la representación de la memoria histórica. Aunque distantes en su concepción, desarrollo, producción y tratamiento, nos centramos en Mad Men (AMC: 2007- y en Cuéntame cómo pasó (Grupo Ganga: 2001- por su importante trabajo de contextualización dramática donde la cultura popular, la visión mediatizada y los mitos se convierten en constantes de sus narraciones. El estudio comparativo de dos nudos dramáticos como son el asesinato de John F. Kennedy en Mad Men y el atentado contra Carrero Blanco en Cuéntame cómo pasó nos permitirá iniciar y profundizar en las formas argumentales, discursivas y estéticas de ambas producciones dentro de su desarrollo en continuidad como obras de ficción de largo recorrido.Palabras clave: series de televisión, ficción, memoria, historia, representación, Mad Men, Cuéntame cómo pasó, cultura popular, identidad.AbstractTelevision series have challenged the drama by constructing a personal and differentiated discourse, turning it into one of the contemporary artistic genres experiencing the greatest expansion at the moment. In this article, we’ve undertaken the study of such series as new cultural artifacts that work with multiple realities and narrative levels, creating fictions that garner commercial success, and new audiovisual parcels that generate reflections on the representations of historical memory. Although distinct in their conception, development, production and material, we will focus on the series Mad

  13. Description et usages d’un nouveau dispositif de vidéo-cours : l’encre numérique

    Directory of Open Access Journals (Sweden)

    Marc Trestini

    2011-06-01

    Full Text Available Cet article présente un nouveau design de vidéo-cours pour l’enseignement universitaire : « l’encre numérique ». Il rend compte de son impact sur l’apprentissage et décrit le profil cognitif des étudiants pour qui ce dispositif semble produire les meilleurs résultats. Le dispositif étudié est constitué d’un Tablet PC associé à un cahier de textes en ligne. Le Tablet PC permet de vidéoprojeter ce que l’enseignant avait coutume d’écrire auparavant au tableau et le cahier de textes de restituer, en ligne, l’ensemble des traces du cours (visuelles, sonores, textuelles. L’étude du dispositif s’appuie sur les résultats des étudiants aux examens, la fréquence de consultation des ressources, ainsi que sur la manière dont elles sont consultées. Cette étude met en évidence certaines caractéristiques et affordances du dispositif qui semblent avoir un effet bénéfique sur les apprentissages et ce, en fonction du profil cognitif de l’étudiant.This paper presents a new design of video courses for university teaching. It is called "digital ink". It shows its impact on student learning and describes the cognitive profile of students for which this device seems to produce the best results. The device which is studied consists of a Tablet PC combined with a work agenda on line. The Tablet PC enables one to project what the teacher traditionally wrote on the board. That is to say; explanatory notes, equations and hand-written diagrams. The teacher has a writing tool (digital light pen which allows cursive script (handwriting on a computer. All written records produced by the teacher during the course, accompanied by verbal comments are recorded. The study of this device is based on student performance on exams, how often they consulted the videos as well as the manner of consulting them. This study shows the impact of this new device on student learning according to their cognitive profile.

  14. Seasonal and spatial variations in fish and macrocrustacean assemblage structure in Mad Island Marsh estuary, Texas

    Science.gov (United States)

    Akin, S.; Winemiller, K. O.; Gelwick, F. P.

    2003-05-01

    Fish and macrocrustacean assemblage structure was analyzed along an estuarine gradient at Mad Island Marsh (MIM), Matagorda Bay, TX, during March 1998-August 1999. Eight estuarine-dependent fish species accounted for 94% of the individual fishes collected, and three species accounted for 96% of macrocrustacean abundance. Consistent with evidence from other Gulf of Mexico estuarine studies, species richness and abundance were highest during late spring and summer, and lowest during winter and early spring. Sites near the bay supported the most individuals and species. Associations between fish abundance and environmental variables were examined with canonical correspondence analysis. The dominant gradient was associated with water depth and distance from the bay. The secondary gradient reflected seasonal variation and was associated with temperature, salinity, dissolved oxygen, and vegetation cover. At the scales examined, estuarine biota responded to seasonal variation more than spatial variation. Estuarine-dependent species dominated the fauna and were common throughout the open waters of the shallow lake during winter-early spring when water temperature and salinity were low and dissolved oxygen high. During summer-early fall, sub-optimal environmental conditions (high temperature, low DO) in upper reaches accounted for strong spatial variation in assemblage composition. Small estuarine-resident fishes and the blue crab ( Callinectes sapidus) were common in warm, shallow, vegetated inland sites during summer-fall. Estuarine-dependent species were common at deeper, more saline locations near the bay during this period. During summer, freshwater species, such as gizzard shad ( Dorosoma cepedianum) and gars ( Lepisosteus spp.), were positively associated with water depth and proximity to the bay. The distribution and abundance of fishes in MIM appear to result from the combined effects of endogenous, seasonal patterns of reproduction and migration operating on large

  15. Mad scientists, compassionate healers, and greedy egotists: the portrayal of physicians in the movies.

    Science.gov (United States)

    Flores, Glenn

    2002-07-01

    Cinematic depictions of physicians potentially can affect public expectations and the patient-physician relationship, but little attention has been devoted to portrayals of physicians in movies. The objective of the study was the analysis of cinematic depictions of physicians to determine common demographic attributes of movie physicians, major themes, and whether portrayals have changed over time. All movies released on videotape with physicians as main characters and readily available to the public were viewed in their entirety. Data were collected on physician characteristics, diagnoses, and medical accuracy, and dialogue concerning physicians was transcribed. The results showed that in the 131 films, movie physicians were significantly more likely to be male (p film physicians has declined steadily in recent decades. Movie physicians are most commonly surgeons (33%), psychiatrists (26%), and family practitioners (18%). Physicians were portrayed negatively in 44% of movies, and since the 1960s positive portrayals declined while negative portrayals increased. Physicians frequently are depicted as greedy, egotistical, uncaring, and unethical, especially in recent films. Medical inaccuracies occurred in 27% of films. Compassion and idealism were common in early physician movies but are increasingly scarce in recent decades. A recurrent theme is the "mad scientist," the physician-researcher that values research more than patients' welfare. Portrayals of physicians as egotistical and materialistic have increased, whereas sexism and racism have waned. Movies from the past two decades have explored critical issues surrounding medical ethics and managed care. We conclude that negative cinematic portrayals of physicians are on the rise, which may adversely affect patient expectations and the patient-physician relationship. Nevertheless, films about physicians can serve as useful gauges of public opinion about the medical profession, as tools for medical education, and as

  16. Comunicación en sistemas de múltiples robots desde la metodología MAD-Smart

    Directory of Open Access Journals (Sweden)

    Jovani Alberto Jiménez Builes

    2008-05-01

    Full Text Available Este artículo demuestra la importancia de la comunicación en sistemas de múltiples robots enmarcado desde la me-todología MAD-Smart. La metodología está compuesta por las fases de conceptuación, análisis y diseño de equipos de múltiples robots mediante la definición de un conjunto de actividades. El propósito de MAD-Smart es ayudar al desarrollador a entender mejor el problema a resolver, las características finales que deberá tener el sistema y el papel que cada agente juega en la solución del problema. La metodología se ha validado mediante la implemen-tación de los proyectos Smart (Sistema multiagente robótico, robótica educativa: máquinas inteligentes en educa-ción y modelo de sensórica y percepción en agentes robóticos para la identificación de materiales. MAD-Smart ha demostrado que es más relevante el manejo de roles, que los agentes mismos para el modelo de comunicación. Lo anterior obedece al grado de abstracción buscado en la metodología, ya que un rol como una representación abs-tracta de un comportamiento de alto nivel permite generalizar de mejor manera los escenarios posibles que se pue-den encontrar en un sistema determinado.

  17. Hubungan Metilasi DNA dengan Ekspresi Gen MADS-box pada Buah Mantel Tanaman Kelapa Sawit (Elaeis guineensis Jacq.

    Directory of Open Access Journals (Sweden)

    Maharani Anischan

    2015-03-01

    Full Text Available ABSTRACT The presence of mantled fruit on large-scale clonal production of oil palm had trully decreased the oil productivity. Mantled phenotype is likely to be that of an epigenetic change involving DNA methylation and the MADS-box transcription factor gene which encoded floral organ homeotic transformation. The objectives of this research were to quantify the degree of methylation which determined fruit abnormality through Ultra Performance Liquid Chromatography (UPLC and to study its correlation with the MADS-box EgAGL6, EgAG2, and EgAGA genes expressed on mantled fruit derived from oil palm clonal plants which have been quantified using Quantitative Real-Time PCR (qPCR. This research was arranged in two replications for each gene and cDNA. The expression of the target genes were compared to EF1-α1 as the reference gene. Through the Least Significant Difference (LSD Test at 95% confidence level of qPCR result, EgAGL6 expression was significantly lower in mantled fruit which decreased from 1.88 fold in Abn m to 0.46 fold in Abn. EgAG2 expression was increased non-significantly from 0.91 fold in Abn m to 1.13 fold in Abn, while EgAGA expression was higher in mantled which increased significantly from 1.48 fold in Abn m to 1.71 fold  in Abn. Nuclease S1 digestion and UPLC revealed the genome-wide increase in DNA methylation on mantled fruit (18.33-19.55% compared to its normal counterparts (5.67%. This increased in global DNA methylation was showed by the significant decreased in EgAGL6 transcript level of mantled fruit. This gene assumed to be involved in the development of mantled fruit. Keywords: DNA-methylation, MADS-box genes, Mantled fruit, Quantitative Real-Time PCR

  18. Effect on oxidative stress, hepatic chemical metabolizing parameters, and genotoxic damage of mad honey intake in rats.

    Science.gov (United States)

    Eraslan, G; Kanbur, M; Karabacak, M; Arslan, K; Siliğ, Y; Soyer Sarica, Z; Tekeli, M Y; Taş, A

    2017-01-01

    A total of 66 male Wistar rats were used and six groups (control: 10 animals and experimental: 12 animals) were formed. While a separate control group was established for each study period, mad honey application to the animals in the experimental group was carried out with a single dose (12.5 g kg -1 body weight (b.w.); acute stage), at a dose of 7.5 g kg -1 b.w. for 21 days (subacute stage), and at a dose of 5 g kg -1 b.w. for 60 days (chronic stage). Tissue and blood oxidative stress markers (malondialdehyde (MDA), nitric oxide (NO), 4-hydroxynonenal (HNE), superoxide dismutase, catalase, glutathione (GSH) peroxidase, and glucose-6-phosphate dehydrogenase), hepatic chemical metabolizing parameters in the liver (cytochrome P450 2E1, nicotinamide adenine dinucleotide (NADH)-cytochrome b5 reductase, nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome c reductase (CYTC), GSH S-transferase (GST), and GSH), and micronucleus and comet test in some samples were examined. Findings from the study showed that single and repeated doses given over the period increased MDA, NO, and HNE levels while decreasing/increasing tissue and blood antioxidant enzyme activities. From hepatic chemical metabolizing parameters, GST activity increased in the subacute and chronic stages and CYTC activity increased in the acute period, whereas GSH level decreased in the subacute stage. Changes in tail and head intensities were found in most of the comet results. Mad honey caused oxidative stresses for each exposure period and made some significant changes on the comet test in certain periods for some samples obtained. In other words, according to the available research results obtained, careless consumption of mad honey for different medical purposes is not appropriate.

  19. A MADS box protein interacts with a mating-type protein and is required for fruiting body development in the homothallic ascomycete Sordaria macrospora.

    Science.gov (United States)

    Nolting, Nicole; Pöggeler, Stefanie

    2006-07-01

    MADS box transcription factors control diverse developmental processes in plants, metazoans, and fungi. To analyze the involvement of MADS box proteins in fruiting body development of filamentous ascomycetes, we isolated the mcm1 gene from the homothallic ascomycete Sordaria macrospora, which encodes a putative homologue of the Saccharomyces cerevisiae MADS box protein Mcm1p. Deletion of the S. macrospora mcm1 gene resulted in reduced biomass, increased hyphal branching, and reduced hyphal compartment length during vegetative growth. Furthermore, the S. macrospora Deltamcm1 strain was unable to produce fruiting bodies or ascospores during sexual development. A yeast two-hybrid analysis in conjugation with in vitro analyses demonstrated that the S. macrospora MCM1 protein can interact with the putative transcription factor SMTA-1, encoded by the S. macrospora mating-type locus. These results suggest that the S. macrospora MCM1 protein is involved in the transcriptional regulation of mating-type-specific genes as well as in fruiting body development.

  20. Du Nouveau dans l'enseignement professional au Nouveau Brunswick

    Science.gov (United States)

    Le Blanc, L. F.

    1974-01-01

    In French, the author traces the development of vocational education in New Brunswick; despite a general decrease in school enrollment, adult vocational training has increased. A "modular" carpentry course illustrates an individualized approach minimizing the problem caused by unilingual instruction of students, some of whom speak…

  1. Buying Blood Diamonds and Altering Global Capitalism. Mads Brügger as Unruly Artivist in The Ambassador

    DEFF Research Database (Denmark)

    Reestorff, Camilla Møhring

    2013-01-01

    challenges global inequality in relation to finance and mobility. This critique of global inequality is staged through a peculiar ‘‘unruly artivist’’ provocation. Mads Brügger fictionalises his character and over-identifies with the corrupt diplomat seeking to buy and trade blood diamonds. The film is unruly...... because it rejects any explicit ethical claims and norms of participation, thus reproducing the self-same patterns of inequality that it seeks to document. This article studies the film as an unruly documentary that applies satire, cartoon aesthetics, and culture jamming as its artivist strategy...

  2. PRELIMINARY METHODOLOGICAL PROPOSAL FOR ESTIMATING ENVIRONMENTAL FLOWS IN PROJECTS APPROVED BY THE MINISTRY OF ENVIRONMENT AND SUSTAINABLE DEVELOPMENT (MADS, COLOMBIA

    Directory of Open Access Journals (Sweden)

    Gabriel A. Pinilla Agudelo

    2014-01-01

    Full Text Available ABSTRACT A methodological proposal for estimating environmental flows in large projects approved by Agencia Nacional de Licencias Ambientales (ANLA in Colombian rivers was developed. The project is the result of an agreement between the MADS and the Universidad Nacional de Colombia, Bogotá (UNC. The proposed method begins with an evaluation of hydrological criteria,continues with a hydraulic and water quality validation, and follows with the determination of habitat integrity. This is an iterative process that compares conditions before and after the project construction and allows to obtain the magnitude of a monthly flow that, besides preserving the ecological functions of the river, guarantees the water uses downstream. Regarding to the biotic component, the proposal includes the establishment and monitoring of biotic integrity indices for four aquatic communities (periphyton, macroinvertebrates, riparian vegetation, and fish. The effects that flow reduction may produce in the medium and long term can be assessed by these indices. We present the results of applying the methodology to several projects licensed by the MADS. RESUMEN Se presenta una propuesta metodológica para estimar los caudales ambientales en grandes proyectos licenciados por la Agencia Nacional de Licencias Ambientales (ANLA de Colombia, resultado de un convenio interadministrativo suscrito entre el ahora Ministerio de Ambiente y Desarrollo Sostenible (MADS de Colombia y la Universidad Nacional de Colombia, Bogotá (UNC. El método propuesto parte de garantizar criterios hidrológicos, continúa con una validación hidráulica y de calidad del agua, sigue con la determinación de la integridad del hábitat, en un proceso iterativo que requiere evaluación para las condiciones antes y después de la construcción del proyecto y que permite establecer un caudal que, además de conservar las funciones ecológicas del río, garantiza los usos del recurso aguas abajo. Espec

  3. The influence of media communication on risk perception and behavior related to mad cow disease in South Korea.

    Science.gov (United States)

    Park, Jee-Eun; Sohn, Aeree

    2013-08-01

    The purpose of this study was to ascertain the influence of media communication on risk behavior related to mad cow disease (MCD). Mothers of elementary school students in Seoul were recruited as the survey participants of this study. Media reports affected risk behavior related to MCD. Also, knowledge and attitude toward MCD affects risk behavior. Risk-related information provided by the media should maintain consistency and objectivity. For effective risk communication, there should be an open communication between the government and public, experts, and related industries, who should all collaborate.

  4. Le nouveau monstre du CERN

    CERN Multimedia

    Clot, Philippe

    2007-01-01

    2007 will remain as a key-date in the history of science: in the genevese underground, the LHC is nearly ready to organise and analyse inedites particle collisions. And these infinitely small and fast crashes will give us a new vision of the Universe. (2 pages and numerous photos)

  5. Un Nouveau Monde du Savoir

    International Development Research Centre (IDRC) Digital Library (Canada)

    Si les effets de la mondialisation sur l'économie, la politique ou encore les ..... Il souligne l'importance cruciale d'un plan stratégique d'internationalisation, ...... Lors du recrutement de nouveaux professeurs ( lorsque cette situation est ...

  6. Une proposition de nouveau cartogramme

    Directory of Open Access Journals (Sweden)

    Raymond Badel

    1990-05-01

    Full Text Available Le cartogramme proposé est une technique de recherche-exploration rapide grâce aux possibilités offertes par le micro-ordinateur et sa diffusion. La propriété foncière en vallée d'Aure lui sert de support.

  7. Ferney et son nouveau visage

    CERN Multimedia

    2004-01-01

    Ferney-Voltaire's third annual fête in h. of Voltaire will take place on 26 June. The theme this year is Newton and the emblem is the apple. CERN, which is celebrating its fiftieth anniversary this year, will be participating in the fête, and has sent a magnet to be displayed outside the Town Hall (1 paragraph)

  8. Arabidopsis MADS-Box Transcription Factor AGL21 Acts as Environmental Surveillance of Seed Germination by Regulating ABI5 Expression.

    Science.gov (United States)

    Yu, Lin-Hui; Wu, Jie; Zhang, Zi-Sheng; Miao, Zi-Qing; Zhao, Ping-Xia; Wang, Zhen; Xiang, Cheng-Bin

    2017-06-05

    Seed germination is a crucial checkpoint for plant survival under unfavorable environmental conditions. Abscisic acid (ABA) signaling plays a vital role in integrating environmental information to regulate seed germination. It has been well known that MCM1/AGAMOUS/DEFICIENS/SRF (MADS)-box transcription factors are key regulators of seed and flower development in Arabidopsis. However, little is known about their functions in seed germination. Here we report that MADS-box transcription factor AGL21 is a negative regulator of seed germination and post-germination growth by controlling the expression of ABA-INSENSITIVE 5 (ABI5) in Arabidopsis. The AGL21-overexpressing plants were hypersensitive to ABA, salt, and osmotic stresses during seed germination and early post-germination growth, whereas agl21 mutants were less sensitive. We found that AGL21 positively regulated ABI5 expression in seeds. Consistently, genetic analyses showed that AGL21 is epistatic to ABI5 in controlling seed germination. Chromatin immunoprecipitation assays further demonstrated that AGL21 could directly bind to the ABI5 promoter in plant cells. Moreover, we found that AGL21 responded to multiple environmental stresses and plant hormones during seed germination. Taken together, our results suggest that AGL21 acts as a surveillance integrator that incorporates environmental cues and endogenous hormonal signals into ABA signaling to regulate seed germination and early post-germination growth. Copyright © 2017 The Author. Published by Elsevier Inc. All rights reserved.

  9. The MADS-box transcription factor FgMcm1 regulates cell identity and fungal development in Fusarium graminearum.

    Science.gov (United States)

    Yang, Cui; Liu, Huiquan; Li, Guotian; Liu, Meigang; Yun, Yingzi; Wang, Chenfang; Ma, Zhonghua; Xu, Jin-Rong

    2015-08-01

    In eukaryotic cells, MADS-box genes are known to play major regulatory roles in various biological processes by combinatorial interactions with other transcription factors. In this study, we functionally characterized the FgMCM1 MADS-box gene in Fusarium graminearum, the causal agent of wheat and barley head blight. Deletion of FgMCM1 resulted in the loss of perithecium production and phialide formation. The Fgmcm1 mutant was significantly reduced in virulence, deoxynivalenol biosynthesis and conidiation. In yeast two-hybrid assays, FgMcm1 interacted with Mat1-1-1 and Fst12, two transcription factors important for sexual reproduction. Whereas Fgmcm1 mutants were unstable and produced stunted subcultures, Fgmcm1 mat1-1-1 but not Fgmcm1 fst12 double mutants were stable. Furthermore, spontaneous suppressor mutations occurred frequently in stunted subcultures to recover growth rate. Ribonucleic acid sequencing analysis indicated that a number of sexual reproduction-related genes were upregulated in stunted subcultures compared with the Fgmcm1 mutant, which was downregulated in the expression of genes involved in pathogenesis, secondary metabolism and conidiation. We also showed that culture instability was not observed in the Fvmcm1 mutants of the heterothallic Fusarium verticillioides. Overall, our data indicate that FgMcm1 plays a critical role in the regulation of cell identity, sexual and asexual reproduction, secondary metabolism and pathogenesis in F. graminearum. © 2015 Society for Applied Microbiology and John Wiley & Sons Ltd.

  10. THE DISTANT STRATUM OF UNREASON: EXPRESSIONS OF MADNESS IN THE PORT AND CITY OF MAZATLÁN LATE NINETEENTH CENTURY

    Directory of Open Access Journals (Sweden)

    Griselda Santiago-Pérez

    2017-07-01

    Full Text Available This work deals with aspects of life port, with respect to the inconveniences and constant challenges on the different epidemics and diseases that the inhabitants faced, as well as the role played by the hospital institutions. Aspects taken into account to envision the other side of reality, in opposition to the modernity and progress alluded to by the ruling elite during the Porfirian years, who tried to disguise precariousness in the face of the insolvency of health care. In addition to this, he pays attention mainly to the madness manifestations of demented men and women inside the city and port of Mazatlán in the last years of the XIX century, specifically between 1877 and 1900. The presence of these marked an important guideline between the city for the sake of progress and the ephemeral reality that they faced in relation to the health and order that was intended to have. And in addition it allows to observe the perspective that was had of them, as well as the construction and the association of the causes on the madness. With the participation of these maladjusted individuals, transgressors of order, social deviance and poverty, who tried to be evaded, limiting them to the integration of social coexistence. Under the establishment of disciplinary forms, governed by rules, customs and routines that guided his conduct. The segregation by the mode of behavior, determined the construction of stereotypes by society, the family, doctors and public authorities.

  11. Preliminary methodological proposal for estimating environmental flows in projects approved by the ministry of environment and sustainable development (MADS), Colombia

    International Nuclear Information System (INIS)

    Pinilla Agudelo, Gabriel A; Rodriguez Sandoval, Erasmo A; Camacho Botero, Luis A

    2014-01-01

    A methodological proposal for estimating environmental flows in large projects approved by Agencia Nacional de Licencias Ambientales (ANLA) in Colombian rivers was developed. The project is the result of an agreement between the MADS and the Universidad Nacional de Colombia, Bogota (UNC). The proposed method begins with an evaluation of hydrological criteria, continues with a hydraulic and water quality validation, and follows with the determination of habitat integrity. This is an iterative process that compares conditions before and after the project construction and allows to obtain the magnitude of a monthly flow that, besides preserving the ecological functions of the river, guarantees the water uses downstream. Regarding to the biotic component, the proposal includes the establishment and monitoring of biotic integrity indices for four aquatic communities (periphyton, macro invertebrates, riparian vegetation, and fish). The effects that flow reduction may produce in the medium and long term can be assessed by these indices. We present the results of applying the methodology to several projects licensed by the MADS.

  12. Concurso de Universidades - SB10mad “Ciudad sostenible: la rehabilitación como herramienta”

    Directory of Open Access Journals (Sweden)

    González Díaz, M. J.

    2011-10-01

    Full Text Available The competition was suggested by GBCEspaña and developed by ASA (Sustainability and Architecture Association, according to the items of SB10Mad Conference. The aim was to involve Spain and other Universities abroad in the study of revitalizing existing areas. Contestants had to suggest solutions to reach benefits in a neighborhood selected by themselves, in subjects such as resource’s economy, energy, water, social improvements and mitigating pollution. The success on variety and the quality of solutions suggest this matter as good university training and successful in developing ideas.

    El concurso fue una propuesta de GBCEspaña desarrollada por ASA (Asociación Sostenibilidad y Arquitectura, en concordancia con el Congreso SB10mad, con el objetivo de involucrar a las Universidades (españolas y extranjeras en las estrategias de revitalización de barrios existentes. Los concursantes debían proponer soluciones en materia de economía de recursos, energía, ciclo del agua, mejoras sociales y reducción de contaminación, sobre un barrio de su propia elección. El éxito de participación y calidad en las propuestas permite aventurar esta materia como de gran interés en la formación universitaria y en el desarrollo de soluciones.

  13. L’identification biométrique : vers un nouveau contrôle social ? Biometric Identification: a New Social Control?

    Directory of Open Access Journals (Sweden)

    Gérard Dubey

    2011-02-01

    Full Text Available La biométrie se définit aujourd’hui comme la possibilité d’identifier sur la base de critères purement techniques un individu dans une masse et dans des flux. Elle est indissociable du processus d’informatisation de la société et de l’impéra­tif de traçabilité (des signes, des choses et aujourd’hui des êtres vivants qu’im­pose le recouvrement du monde réel par son image numérique contrôlée et contrôlable. Le déploiement des dispositifs d’identification biométrique illustre ainsi la convergence qui s’opère entre la logique étatique du contrôle à distance et la logique propre au Macro-Système-Technique. Telle est la première thèse défendue dans cet article qui interroge ensuite le type de contrôle et de pouvoir induit par ces nouvelles modalités. La thèse d’un nouveau contrôle social est discutée depuis les données empiriques recueillies auprès des premiers usagers de ces dispositifs et son déterminisme est mis en cause. Le contrôle social auto­matisé, qui épouse les contours du Macro-Système-Technique, mime les mou­vements de la société réelle plus qu’il ne les contrôle. En cela réside sa limite.Biometry is defined today as the possibility of identifying an individual on the basis of purely technical criteria in a mass and in flux. It is indissociable from the process of digitalization of the society and the imperative of traceability (signs, things and today living beings imposed by the covering of the real world by its controlled and controllable numerical image. The spread of biometric identification mechanisms thus illustrates the convergence in operation between the State logic of long-distance control and the logic proper to Technical-Macro-Systems. That is the first thesis defended in this article, which then asks about the type of control and power exercised by these new means. The thesis of a new social control is discussed based on the empirical data gathered among the

  14. L'effet Peltier appliqué à la conception et la réalisation d'un nouveau capteur de débit massique

    Science.gov (United States)

    Wattiau, F.; Gaviot, E.; Thery, P.

    1993-08-01

    éalisation d'un nouveau capteur de débit massique basé sur l'effet Peltier. Le capteur en forme de circuit imprimé bimétallique, comporte plusieurs pistes métalliques continues parallèles entre elles et partiellement recouvertes par un grand nombre de dépôts électrolytiques de nature différente. Un tel circuit se comporte comme un circuit thermoélectrique classique dans lequel les parties homogènes non recouvertes par le dépôt électrolytique constituent le premier conducteur du couple, les parties plaquées constituant le second conducteur. La méthode de mesure consiste à faire passer un courant électrique dans une ou plusieurs pistes constituant le circuit émetteur de façon à générer par effet Peltier des gradients thermiques qui seront détectés par un circuit détecteur identique placé à proximité. Dans le cas particulier d'un fluide au repos, la f.e.m. détectée par le circuit détecteur dépend de la conductivité thermique du fluide. Lorsque le fluide est en mouvement relatif par rapport au circuit, il est possible de détecter une f.e.m. dépendant en grandeur et en signe de la vitesse d'écoulement du fluide. A titre d'application un capteur de débit massique a été réalisé en plaçant les circuits thermoélectriques dans une canalisation parcourue par le fluide en mouvement.

  15. Overexpression of the class D MADS-box gene Sl-AGL11 impacts fleshy tissue differentiation and structure in tomato fruits

    Science.gov (United States)

    MADS-box transcription factors are key elements of the genetic networks controlling flower and fruit development. Among these, the class D clade are involved in seed, ovule, and funiculus development. The tomato genome comprises two class D genes, Sl-AGL11 and Sl-MBP3, both displaying high expressio...

  16. Banana MaMADS transcription factors are necessary for fruit ripening and molecular tools to promote shelf-life and food security

    Science.gov (United States)

    Genetic solutions to postharvest crop loss can reduce cost and energy inputs while increasing food security, especially for banana (Musa acuminata), which is a significant component of worldwide food commerce. We have functionally characterized two banana E class (SEPALLATA3 [SEP3]) MADS box genes, ...

  17. 'Where of is mad al mankynde' : an edition of and introduction to the twenty-four poems in Oxford, Bodleian Library, MS Digby 102

    NARCIS (Netherlands)

    Verheij, Louis Johan Philip

    2009-01-01

    'Where of is Mad al Mankynde' represents a new critical edition of the collection of twenty-four late-medieval anonymous poems contained, among other pieces, in Oxford, Bodleian Library, MS Digby 102. Each poem is introduced with a brief summary and closes with line-for-line explanatory comments.

  18. Identification and quantification of expression levels of three FRUITFULL-like MADS-box genes from the orchid Dendrobium thyrsiflorum (Reichb. f.)

    DEFF Research Database (Denmark)

    Skipper, Martin; Pedersen, Kim B.; Johansen, Louise Buchholt

    2005-01-01

    Orchids serve as useful model plants for the discovery and study of genes involved in novel processes in floral development because of their highly modified flowers. In this study three different FRUITFULL (FUL)-like MADS-box genes, DthyrFL1, -2, and -3 have been isolated from the orchid Dendrobium...

  19. Genome-wide analysis of the MADS-box gene family in polyploid cotton (Gossypium hirsutum) and in its diploid parental species (Gossypium arboreum and Gossypium raimondii).

    Science.gov (United States)

    Nardeli, Sarah Muniz; Artico, Sinara; Aoyagi, Gustavo Mitsunori; de Moura, Stéfanie Menezes; da Franca Silva, Tatiane; Grossi-de-Sa, Maria Fatima; Romanel, Elisson; Alves-Ferreira, Marcio

    2018-06-01

    The MADS-box gene family encodes transcription factors that share a highly conserved domain known to bind to DNA. Members of this family control various processes of development in plants, from root formation to fruit ripening. In this work, a survey of diploid (Gossypium raimondii and Gossypium arboreum) and tetraploid (Gossypium hirsutum) cotton genomes found a total of 147, 133 and 207 MADS-box genes, respectively, distributed in the MIKC, Mα, Mβ, Mγ, and Mδ subclades. A comparative phylogenetic analysis among cotton species, Arabidopsis, poplar and grapevine MADS-box homologous genes allowed us to evaluate the evolution of each MADS-box lineage in cotton plants and identify sequences within well-established subfamilies. Chromosomal localization and phylogenetic analysis revealed that G. raimondii and G. arboreum showed a conserved evolution of the MIKC subclade and a distinct pattern of duplication events in the Mα, Mγ and Mδ subclades. Additionally, G. hirsutum showed a combination of its parental subgenomes followed by a distinct evolutionary history including gene gain and loss in each subclade. qPCR analysis revealed the expression patterns of putative homologs in the AP1, AP3, AGL6, SEP4, AGL15, AG, AGL17, TM8, SVP, SOC and TT16 subfamilies of G. hirsutum. The identification of putative cotton orthologs is discussed in the light of evolution and gene expression data from other plants. This analysis of the MADS-box genes in Gossypium species opens an avenue to understanding the origin and evolution of each gene subfamily within diploid and polyploid species and paves the way for functional studies in cotton species. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  20. Cloning, Structural Characterization, and Phylogenetic Analysis of Flower MADS-Box Genes from Crocus (Crocus sativus L.

    Directory of Open Access Journals (Sweden)

    Athanasios S. Tsaftaris

    2007-01-01

    Full Text Available Crocus (Crocus sativus L. is a crop species cultivated for its flowers and, more specifically, for its red stigmas. The flower of crocus is bisexual and sterile, since crocus is a triploid species. Its perianth consists of six petaloid tepals: three tepals in whorl 1 (outer tepals and three tepals in whorl 2 (inner tepals. The androecium consists of three distinct stamens and the gynoecium consists of a single compound pistil with three carpels, a single three-branched style, and an inferior ovary. The dry form of the stigmas constitutes the commercial saffron used as a food additive, in the coloring industry, and in medicine. In order to uncover and understand the molecular mechanisms controlling flower development in cultivated crocus and its relative wild progenitor species, and characterize a number of crocus flower mutants, we have cloned and characterized different, full-length, cDNA sequences encoding MADS-box transcription factor proteins involved in flower formation.

  1. Madness, Monstrosity and Writing: Towards a Genealogical Analysis in 'El obsceno pájaro de la noche'

    Directory of Open Access Journals (Sweden)

    Santiago Juan-Navarro

    2016-06-01

    Full Text Available Drawing on Foucault’s concept of “genealogy,” this article explores madness, monstrosity and writing in José Donoso´s The Obscene Bird of Night(1970. Like Foucault, Donoso is interested in studying the body as “the inscribed surface of events,” the locus of a dissociated self (adopting the illusion of a substantial unity, and a mass in perpetual disintegration. Like Donoso, Foucault assaults enlightened reason and the principle of reality in order to subvert and transgress the instrumental rationality and normalcy of bourgeois culture. This essay analyzes Donoso’s novel in light of these concepts in order to open a new path for understanding one of the most obscure texts in modern Latin American fiction.

  2. Conifer reproductive development involves B-type MADS-box genes with distinct and different activities in male organ primordia.

    Science.gov (United States)

    Sundström, Jens; Engström, Peter

    2002-07-01

    The Norway spruce MADS-box genes DAL11, DAL12 and DAL13 are phylogenetically related to the angiosperm B-function MADS-box genes: genes that act together with A-function genes in specifying petal identity and with C-function genes in specifying stamen identity to floral organs. In this report we present evidence to suggest that the B-gene function in the specification of identity of the pollen-bearing organs has been conserved between conifers and angiosperms. Expression of DAL11 or DAL12 in transgenic Arabidopsis causes phenotypic changes which partly resemble those caused by ectopic expression of the endogenous B-genes. In similar experiments, flowers of Arabidopsis plants expressing DAL13 showed a different homeotic change in that they formed ectopic anthers in whorls one, two or four. We also demonstrate the capacity of the spruce gene products to form homodimers, and that DAL11 and DAL13 may form heterodimers with each other and with the Arabidopsis B-protein AP3, but not with PI, the second B-gene product in Arabidopsis. In situ hybridization experiments show that the conifer B-like genes are expressed specifically in developing pollen cones, but differ in both temporal and spatial distribution patterns. These results suggest that the B-function in conifers is dual and is separated into a meristem identity and an organ identity function, the latter function possibly being independent of an interaction with the C-function. Thus, even though an ancestral B-function may have acted in combination with C to specify micro- and megasporangia, the B-function has evolved differently in conifers and angiosperms.

  3. Dormancy-Associated MADS-Box (DAM) and the Abscisic Acid Pathway Regulate Pear Endodormancy Through a Feedback Mechanism.

    Science.gov (United States)

    Tuan, Pham Anh; Bai, Songling; Saito, Takanori; Ito, Akiko; Moriguchi, Takaya

    2017-08-01

    In the pear 'Kosui' (Pyrus pyrifolia Nakai), the dormancy-associated MADS-box (PpDAM1 = PpMADS13-1) gene has been reported to play an essential role in bud endodormancy. Here, we found that PpDAM1 up-regulated expression of 9-cis-epoxycarotenoid dioxygenase (PpNCED3), which is a rate-limiting gene for ABA biosynthesis. Transient assays with a dual luciferase reporter system (LUC assay) and electrophoretic mobility shift assay (EMSA) showed that PpDAM1 activated PpNCED3 expression by binding to the CArG motif in the PpNCED3 promoter. PpNCED3 expression was increased toward endodormancy release in lateral flower buds of 'Kosui', which is consistent with the induced levels of ABA, its catabolism (ABA 8'-hydroxylase) and signaling genes (type 2C protein phosphatase genes and SNF1-related protein kinase 2 genes). In addition, we found that an ABA response element (ABRE)-binding transcription factor, PpAREB1, exhibiting high expression concomitant with endodormancy release, bound to three ABRE motifs in the promoter region of PpDAM1 and negatively regulated its activity. Taken together, our results suggested a feedback regulation between PpDAM1 and the ABA metabolism and signaling pathway during endodormancy of pear. This first evidence of an interaction between a DAM and ABA biosynthesis in vitro will provide further insights into bud endodormancy regulatory mechanisms of deciduous trees including pear. © The Author 2017. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  4. Comprehensive Cloning of Prunus mume Dormancy Associated MADS-Box Genes and Their Response in Flower Bud Development and Dormancy

    Directory of Open Access Journals (Sweden)

    Kai Zhao

    2018-02-01

    Full Text Available Dormancy Associated MADS-box genes are SVP/MADs-box members and supposed to play crucial roles in plant dormancy of perennial species. In Prunus mume, PmDAM6 has been previously identified to induce plant dormancy. In the current study, six PmDAMs were cloned in P. mume and functionally analyzed in yeast and tobacco to detect the roles of the genes paralogous to PmDAM6. The expression patterns together with sequence similarities indicate that PmDAMs are divided into two sub-clades within SVP group. Moreover, PmDAMs are verified to take part in the development of different plant organs, specifically the flower buds, in some intricate patterns. Furthermore, the PmDAM proteins are found to have special functions by forming corresponding protein complex during the development of flower bud and induction of dormancy. In particular, when PmDAM1 dominating in flower bud in the warm months, the protein complexes are consisted of PmDAM1 itself or with PmDAM2. With the decrease temperatures in the following months, PmDAM6 was found to be highly expressed and gradually changed the complex structure to PmDAM6-protein complex due to strong binding tendencies with PmDAM1 and PmDAM3. Finally, the homodimers of PmDAM6 prevailed to induce the dormancy. The results obtained in the current study highlight the functions of PmDAMs in the tissue development and dormancy, which provide available suggestions for further explorations of protein-complex functions in association with bud growth and dormancy.

  5. Morphological "primary homology" and expression of AG-subfamily MADS-box genes in pines, podocarps, and yews.

    Science.gov (United States)

    Englund, Marie; Carlsbecker, Annelie; Engström, Peter; Vergara-Silva, Francisco

    2011-01-01

    The morphological variation among reproductive organs of extant gymnosperms is remarkable, especially among conifers. Several hypotheses concerning morphological homology between various conifer reproductive organs have been put forward, in particular in relation to the pine ovuliferous scale. Here, we use the expression patterns of orthologs of the ABC-model MADS-box gene AGAMOUS (AG) for testing morphological homology hypotheses related to organs of the conifer female cone. To this end, we first developed a tailored 3'RACE procedure that allows reliable amplification of partial sequences highly similar to gymnosperm-derived members of the AG-subfamily of MADS-box genes. Expression patterns of two novel conifer AG orthologs cloned with this procedure-namely PodAG and TgAG, obtained from the podocarp Podocarpus reichei and the yew Taxus globosa, respectively-are then further characterized in the morphologically divergent female cones of these species. The expression patterns of PodAG and TgAG are compared with those of DAL2, a previously discovered Picea abies (Pinaceae) AG ortholog. By treating the expression patterns of DAL2, PodAG, and TgAG as character states mapped onto currently accepted cladogram topologies, we suggest that the epimatium-that is, the podocarp female cone organ previously postulated as a "modified" ovuliferous scale-and the canonical Pinaceae ovuliferous scale can be legitimally conceptualized as "primary homologs." Character state mapping for TgAG suggests in turn that the aril of Taxaceae should be considered as a different type of organ. This work demonstrates how the interaction between developmental-genetic data and formal cladistic theory could fruitfully contribute to gymnosperm systematics. © 2011 Wiley Periodicals, Inc.

  6. Le modèle québécois : origines, définition, fondements et adaptation au nouveau contexte économique et social

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    Pierre-Paul Proulx

    2002-10-01

    Full Text Available À partir de plusieurs écrits sur le modèle québécois et le Québec Inc., l’article montre que ces termes prennent plusieurs significations selon les auteurs. Ainsi, pour certains, ils traduisent un corporatiste, un véritable réseau ou un nationalisme économique ; pour d’autres, ils sont l’expression de la présence française en Amérique du nord ou encore un modèle d’émancipation d’un peuple et d’entreprises francophones. Le modèle de développement émerge des grands acteurs socio-économiques de ces dernières soixante années et ses caractéristiques permettent de saisir la notion d’intérêt général comme étant l’expression d’une communauté de personnes et non d’un marché. Plus qu’un concept qui chapeaute une classe d’affaire, Québec Inc serait un véritable projet de société et l’expression d’un modèle de développement fondé sur une alliance particulière entre les pouvoirs économiques public et privé dont l’objectif a été et continu d’être la poursuite d’une politique de croissance par la prise en main des leviers économiques du Québec. Enfin, il n’est rien d’autre qu’un désir "naturel" de concertation dans un monde où le regroupement des forces et des intelligences s’impose. Mais pour un renouvellement du modèle, un partage d’objectifs de la part des acteurs impliqués s’avère important de même qu’une "recapitalisation" sociale. L’article se termine en soulignant l’importance de la concertation et de la solidarité comme du capital social dont un nouveau modèle québécois dans un contexte actuel ne peut en faire l’économie.From several papers on the Quebecois model and Quebec Inc ., the article shows that these terms take several meanings according to the authors. So, for some, they translate a corporatist, a real network or an economic nationalism; for others, they are the expression of the french presence in North America or another model of

  7. Investigating the Impact of a Genome-Wide Supported Bipolar Risk Variant of MAD1L1 on the Human Reward System.

    Science.gov (United States)

    Trost, Sarah; Diekhof, Esther K; Mohr, Holger; Vieker, Henning; Krämer, Bernd; Wolf, Claudia; Keil, Maria; Dechent, Peter; Binder, Elisabeth B; Gruber, Oliver

    2016-10-01

    Recent genome-wide association studies have identified MAD1L1 (mitotic arrest deficient-like 1) as a susceptibility gene for bipolar disorder and schizophrenia. The minor allele of the single-nucleotide polymorphism (SNP) rs11764590 in MAD1L1 was associated with bipolar disorder. Both diseases, bipolar disorder and schizophrenia, are linked to functional alterations in the reward system. We aimed at investigating possible effects of the MAD1L1 rs11764590 risk allele on reward systems functioning in healthy adults. A large homogenous sample of 224 young (aged 18-31 years) participants was genotyped and underwent functional magnetic resonance imaging (fMRI). All participants performed the 'Desire-Reason Dilemma' paradigm investigating the neural correlates that underlie reward processing and active reward dismissal in favor of a long-term goal. We found significant hypoactivations of the ventral tegmental area (VTA), the bilateral striatum and bilateral frontal and parietal cortices in response to conditioned reward stimuli in the risk allele carriers compared with major allele carriers. In the dilemma situation, functional connectivity between prefrontal brain regions and the ventral striatum was significantly diminished in the risk allele carriers. Healthy risk allele carriers showed a significant deficit of their bottom-up response to conditioned reward stimuli in the bilateral VTA and striatum. Furthermore, functional connectivity between the ventral striatum and prefrontal areas exerting top-down control on the mesolimbic reward system was reduced in this group. Similar alterations in reward processing and disturbances of prefrontal control mechanisms on mesolimbic brain circuits have also been reported in bipolar disorder and schizophrenia. Together, these findings suggest the existence of an intermediate phenotype associated with MAD1L1.

  8. An integrin alpha4beta7•IgG heterodimeric chimera binds to MAdCAM-1 on high endothelial venules in gut-associated lymphoid tissue.

    Science.gov (United States)

    Hoshino, Hitomi; Kobayashi, Motohiro; Mitoma, Junya; Sato, Yoshiko; Fukuda, Minoru; Nakayama, Jun

    2011-06-01

    Lymphocyte homing is regulated by a multistep process mediated by sequential adhesive interactions between circulating lymphocytes and high endothelial venules (HEVs). In gut-associated lymphoid tissue (GALT), the initial interactive step, "tethering and rolling," is partly mediated by integrin α4β7 expressed on GALT-homing lymphocytes and its ligand MAdCAM-1, which is exclusively expressed on HEVs in GALT. To probe functional MAdCAM-1 in tissue sections, we developed a soluble integrin α4β7 heterodimeric IgG chimera by joining the extracellular region of mouse integrin α4 and β7 subunits to a human IgG Fc domain. Western blot analysis revealed that co-transfection of HEK 293T cells with expression vectors encoding integrin α4•IgG and β7•IgG results in the formation of α4β7•IgG heterodimeric chimeras. This complex preferentially binds to CHO cells expressing MAdCAM-1 and, to a lesser extent, to cells expressing VCAM-1, but not to cells expressing ICAM-1. Moreover, α4β7•IgG specifically binds to HEVs in GALT in situ in a divalent cation-dependent fashion and inhibits lymphocyte binding to HEVs in GALT. These findings indicate that α4β7•IgG can be used as a probe for functional MAdCAM-1 expressed on HEVs in GALT and could potentially serve as an anti-inflammatory drug inhibiting GALT-specific lymphocyte migration.

  9. "Now he walks and walks, as if he didn't have a home where he could eat": food, healing, and hunger in Quechua narratives of madness.

    Science.gov (United States)

    Orr, David M R

    2013-12-01

    In the Quechua-speaking peasant communities of southern Peru, mental disorder is understood less as individualized pathology and more as a disturbance in family and social relationships. For many Andeans, food and feeding are ontologically fundamental to such relationships. This paper uses data from interviews and participant observation in a rural province of Cuzco to explore the significance of food and hunger in local discussions of madness. Carers' narratives, explanatory models, and theories of healing all draw heavily from idioms of food sharing and consumption in making sense of affliction, and these concepts structure understandings of madness that differ significantly from those assumed by formal mental health services. Greater awareness of the salience of these themes could strengthen the input of psychiatric and psychological care with this population and enhance knowledge of the alternative treatments that they use. Moreover, this case provides lessons for the global mental health movement on the importance of openness to the ways in which indigenous cultures may construct health, madness, and sociality. Such local meanings should be considered by mental health workers delivering services in order to provide care that can adjust to the alternative ontologies of sufferers and carers.

  10. Duplication and diversification of the LEAFY HULL STERILE1 and Oryza sativa MADS5 SEPALLATA lineages in graminoid Poales

    Directory of Open Access Journals (Sweden)

    Christensen Ashley R

    2012-02-01

    Full Text Available Abstract Background Gene duplication and the subsequent divergence in function of the resulting paralogs via subfunctionalization and/or neofunctionalization is hypothesized to have played a major role in the evolution of plant form. The LEAFY HULL STERILE1 (LHS1 SEPALLATA (SEP genes have been linked with the origin and diversification of the grass spikelet, but it is uncertain 1 when the duplication event that produced the LHS1 clade and its paralogous lineage Oryza sativa MADS5 (OSM5 occurred, and 2 how changes in gene structure and/or expression might have contributed to subfunctionalization and/or neofunctionalization in the two lineages. Methods Phylogenetic relationships among 84 SEP genes were estimated using Bayesian methods. RNA expression patterns were inferred using in situ hybridization. The patterns of protein sequence and RNA expression evolution were reconstructed using maximum parsimony (MP and maximum likelihood (ML methods, respectively. Results Phylogenetic analyses mapped the LHS1/OSM5 duplication event to the base of the grass family. MP character reconstructions estimated a change from cytosine to thymine in the first codon position of the first amino acid after the Zea mays MADS3 (ZMM3 domain converted a glutamine to a stop codon in the OSM5 ancestor following the LHS1/OSM5 duplication event. RNA expression analyses of OSM5 co-orthologs in Avena sativa, Chasmanthium latifolium, Hordeum vulgare, Pennisetum glaucum, and Sorghum bicolor followed by ML reconstructions of these data and previously published analyses estimated a complex pattern of gain and loss of LHS1 and OSM5 expression in different floral organs and different flowers within the spikelet or inflorescence. Conclusions Previous authors have reported that rice OSM5 and LHS1 proteins have different interaction partners indicating that the truncation of OSM5 following the LHS1/OSM5 duplication event has resulted in both partitioned and potentially novel gene

  11. A study of the various baffles used in the Marcoule chimneys and the search for a new model (1961); Etude des differents deflecteurs utilises pour les cheminees de Marcoule et recherche d'un nouveau type de deflecteur (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Chassany, J [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires; Parigi, H [Institut de Mecanique des Fluides de Marseille, 13 (France); Salaun-Penquer, G [Centre National de la Recherche Scientifique (CNRS), 75 - Paris (France)

    1961-07-01

    The baffle placed at the top of a chimney determines the shape of the smoke pall for low exit-velocities. The G. 1 type baffle was studied taking into account the characteristics of its collar: totally hollow - partially hollow - solid; on a ribbed chimney or on a plain chimney. The Pu type baffle was also tested. The search for a new type of baffle was limited to variants of the blade - type baffle: - a porous envelope device; - a cone - shaped device and - a deflector of the cupel type. Only the blade-type baffle was rejected, efficient solutions are proposed using the other types or their combinations. (authors) [French] Le deflecteur place au sommet d'une cheminee conditionne l'allure du panache pour les rejets a faible vitesse de sortie. Le deflecteur type Gl a ete etudie en tenant compte de son embase: totalement evidee - partiellement evidee - pleine; sur une cheminee striee et sur une cheminee lisse. Le deflecteur type Pu a ete egalement teste. La recherche d'un nouveau type de deflecteur a porte sur les deflecteurs a aubage: - un dispositif a enveloppe poreuse; - un dispositif en ogive et - le deflecteur en coupelle. Seul le deflecteur a aubage a ete rejete, des solutions efficaces sont proposees avec les autres types ou leur combinaison. (auteurs)

  12. The madness of crowds phenomenon in the collective decision-making by the cells, the cell's metacognition and cancer

    Science.gov (United States)

    Saakian, David B.

    2018-02-01

    Recently it has been found that the collective decision-making in the group is efficient only when the confidences (a version of metacognition) of the members are similar, and it has been assumed that the metacognition (self-reference) in general is crucial for the human cooperation. Our goal is to map the decision making by the cells to decision making by humans, looking the analog of metacognition in the cells, accurately calculate the collective sensing of chemical gradients by the cells, and apply our results to cancer. We formulated the model for the chemeosensing by the cells with different diameters, solved it accurately and found that the collective chemosensing is very similar to the collective decision making by humans. We found that the collective sensing of the ligand concentration can be worse than for the most sensitive cell. We introduced the metacognition of the cells, and verify that the metacognition is impaired for the cancer case. We assume as a hypothesis that the impaired cell metacognition in case of cancer does not allow normal multi-cellularity, and cancer can arise when the "two heads are better than one" principle fails, and there is a "madness of crowds" phenomenon instead.

  13. Madness and the Middle Passage: Warner-Vierya's Juletane as a Paradigm for Writing Caribbean Women's Identities

    Directory of Open Access Journals (Sweden)

    Ann Elizabeth Willey

    1997-06-01

    Full Text Available This article links Glissant's theory of an inherent Caribbean madness due to the originary rupture and alienation from Africa with Foucault's theory of the ritual significance and essential liminality of the madman as exemplified in the medieval figure of the "Ship of Fools." In calling the madman the "passenger par excellence," Foucault implies a connection between sanity and linear narratives, such as that of a voyage. Myriam Warner-Vierya's novel, Juletane , suggests that European paradigms of narrative and voyage are inadequate to provide a sense of self for Caribbean women. The novel takes the form of a diary that chronicles the steadily disintegrating marriage and sanity of Juletane, a Caribbean woman orphaned at ten, raised in Paris, who meets and marries an African student in an effort to find a new identity in her husband and a return to Africa. The novel suggests that the linear narrative of a return to the source in Africa denies the rupture with Africa and the immediate circumstances of Caribbean subject-hood. In her efforts, Juletane ignores the alternative narrative possibilities that the novel presents in the circular and shared narratives of women that do not depend on a sense of closure or arrival, but like the voyage of the madman, remain open to the infinite crossroads of the sea and narration.

  14. Motifs of Madness, Indifference, and Cannibalism as Symbols of a Depraved Society in Lu Xun's Short Stories

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    Tina Ilgo

    2011-07-01

    Full Text Available This article analyzes two short stories by Lu Xun from his collection Outcry, which came into being at the culmination of the Chinese spiritual rebirth between 1818 and 1922. In “Diary of a Madman” and “The True Story of A Q” the author expresses his conviction that the existing system’s depravity produces “cannibalism,” causes a gradual decline in humanity, and exposes the main defects of human character. The impossibility of destroying the “iron house,” or people’s incapacity to change their “cannibalistic” nature, causes the loss of hope on the side of the “madmen” . It forces them to give up their insightfull knowledge and adapt to the majority. With the repetition of motifs such as “madness,” “indifference,” and “cannibalism,” which constantly recur in Lu Xun’s short stories, the author expressed his vision of traditional Chinese society and his pessimism about the future. At the same time these motifs reflect the author’s state of mind and his everlasting journey between hope and despair, “madness” and “indifference,” and tradition and modernity. If the stories are read in the context of twentieth-century China they can be understood as a direct criticism of the established Chinese society, whose values and norms derive from Confucianism, but they also contain deep symbolic meaning that renders them timeless.

  15. Gender, Madness, Religion, and Iranian-American Identity: Observations on a 2006 Murder Trial in Williamsport, Pennsylvania

    Directory of Open Access Journals (Sweden)

    Camron Michael Amin

    2017-08-01

    Full Text Available Using participant observation, oral history interviews, and a study of court transcripts, Internet chats, and press coverage of a 2006 murder trial of an Iranian-American man in Williamsport, Pennsylvania, we can better appreciate the dynamic intersection of ethnicity, religion, and gender in constructing the social identity of Iranian-Americans. Brian Hosayn Yasipour, who immigrated to the United States in 1969, was convicted of murder in the third degree for killing his four-year-old daughter in 2001 during a custody dispute with his estranged, Iranian-born wife. He managed to avoid the death penalty. Debates about his guilt in America hinged on assessments of his mental state at the time of the crime and this, in turn, hinged on debates about how normative his actions would have been in Iran. Until his arrest, Brian had led a highly mobile life—moving back and forth between America, where he lived as a Christian, and Iran, where he visited as a Muslim. Was he a calculating Iranian-Islamic patriarch, outraged at the defiance of his wife and the attitudes of American courts toward his paternal rights? Or was he, per the court transcripts, a “white Christian” and survivor of childhood rape back in Iran, who lapsed into madness under the strain of his second divorce? Brian actively blurred these issues in court appearances before and after the murder—often expressing his agency in terms of preserving his imaginary and physical mobility.

  16. Madness in the movies: An evaluation of the use of cinema to explore mental health issues in nurse education.

    Science.gov (United States)

    McCann, Edward; Huntley-Moore, Sylvia

    2016-11-01

    The research literature on the use of cinema in nurse education is relatively small. This study evaluates student nurses' learning experiences of a new undergraduate elective module called Madness in the Movies. Ethical approval was granted to conduct the study. Data were collected through an online survey and a social media discussion forum. The anonymous online survey responses were collated via Survey Monkey. Content analysis was conducted on the data from the Facebook discussion threads to understand, interpret and conceptualise the meanings from the data. All study participants agreed that their understanding of mental health issues was enriched, their attitudes and beliefs enhanced and their confidence to talk about mental health concerns increased significantly. This module provides a fruitful approach to encourage critical reflection on mental health issues in a safe environment that closely mirrors authentic practice experiences. The module facilitates the development of students' knowledge, values and attitudes in relation to person-centred mental healthcare. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Characterization and Functional Analysis of Five MADS-Box B Class Genes Related to Floral Organ Identification in Tagetes erecta.

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    Ye Ai

    Full Text Available According to the floral organ development ABC model, B class genes specify petal and stamen identification. In order to study the function of B class genes in flower development of Tagetes erecta, five MADS-box B class genes were identified and their expression and putative functions were studied. Sequence comparisons and phylogenetic analyses indicated that there were one PI-like gene-TePI, two euAP3-like genes-TeAP3-1 and TeAP3-2, and two TM6-like genes-TeTM6-1 and TeTM6-2 in T. erecta. Strong expression levels of these genes were detected in stamens of the disk florets, but little or no expression was detected in bracts, receptacles or vegetative organs. Yeast hybrid experiments of the B class proteins showed that TePI protein could form a homodimer and heterodimers with all the other four B class proteins TeAP3-1, TeAP3-2, TeTM6-1 and TeTM6-2. No homodimer or interaction was observed between the euAP3 and TM6 clade members. Over-expression of five B class genes of T. erecta in Nicotiana rotundifolia showed that only the transgenic plants of 35S::TePI showed altered floral morphology compared with the non-transgenic line. This study could contribute to the understanding of the function of B class genes in flower development of T. erecta, and provide a theoretical basis for further research to change floral organ structures and create new materials for plant breeding.

  18. A novel MADS-box gene subfamily with a sister-group relationship to class B floral homeotic genes.

    Science.gov (United States)

    Becker, A; Kaufmann, K; Freialdenhoven, A; Vincent, C; Li, M-A; Saedler, H; Theissen, G

    2002-02-01

    Class B floral homeotic genes specify the identity of petals and stamens during the development of angiosperm flowers. Recently, putative orthologs of these genes have been identified in different gymnosperms. Together, these genes constitute a clade, termed B genes. Here we report that diverse seed plants also contain members of a hitherto unknown sister clade of the B genes, termed B(sister) (B(s)) genes. We have isolated members of the B(s) clade from the gymnosperm Gnetum gnemon, the monocotyledonous angiosperm Zea mays and the eudicots Arabidopsis thaliana and Antirrhinum majus. In addition, MADS-box genes from the basal angiosperm Asarum europaeum and the eudicot Petunia hybrida were identified as B(s) genes. Comprehensive expression studies revealed that B(s) genes are mainly transcribed in female reproductive organs (ovules and carpel walls). This is in clear contrast to the B genes, which are predominantly expressed in male reproductive organs (and in angiosperm petals). Our data suggest that the B(s) genes played an important role during the evolution of the reproductive structures in seed plants. The establishment of distinct B and B(s) gene lineages after duplication of an ancestral gene may have accompanied the evolution of male microsporophylls and female megasporophylls 400-300 million years ago. During flower evolution, expression of B(s) genes diversified, but the focus of expression remained in female reproductive organs. Our findings imply that a clade of highly conserved close relatives of class B floral homeotic genes has been completely overlooked until recently and awaits further evaluation of its developmental and evolutionary importance. Electronic supplementary material to this paper can be obtained by using the Springer Link server located at http://dx.doi.org/10.1007/s00438-001-0615-8.

  19. Expression of paralogous SEP-, FUL-, AG- and STK-like MADS-box genes in wild-type and peloric Phalaenopsis flowers.

    Directory of Open Access Journals (Sweden)

    Roberta eAcri-Nunes-Miranda

    2014-03-01

    Full Text Available The diverse flowers of Orchidaceae are the result of several major morphological transitions, among them the most studied is the differentiation of the inner median tepal into the labellum, a perianth organ key in pollinator attraction. Type A peloria lacking stamens and with ectopic labella in place of inner lateral tepals are useful for testing models on the genes specifying these organs by comparing their patterns of expression between wild-type and peloric flowers. Previous studies focused on DEFICIENS and GLOBOSA-like MADS-box genes because of their conserved role in perianth and stamen development. The ‘orchid code’ model summarizes this work and shows in Orchidaceae there are four paralogous lineages of DEFICIENS/AP3-like genes differentially expressed in each floral whorl. Experimental tests of this model showed the conserved, higher expression of genes from two specific DEF-like gene lineages is associated with labellum development. The present study tests whether eight MADS-box candidate SEP-, FUL-, AG- and STK-like genes have been specifically duplicated in the Orchidaceae and are also differentially expressed in association with the distinct flower organs of Phalaenopsis hyb. Athens. The gene trees indicate orchid-specific duplications. In a way analogous to what is observed in labellum-specific DEF-like genes, a two-fold increase in the expression of SEP3-like gene PhaMADS7 was measured in the labellum-like inner lateral tepals of peloric flowers. The overlap between SEP3-like and DEF-like genes suggests both are associated with labellum specification and similar positional cues determine their domains of expression. In contrast, the uniform messenger levels of FUL-like genes suggest they are involved in the development of all organs and their expression in the ovary suggests cell differentiation starts before pollination. As previously reported AG-like and STK-like are exclusively expressed in gynostemium and ovary, however no

  20. Expression of paralogous SEP-, FUL-, AG- and STK-like MADS-box genes in wild-type and peloric Phalaenopsis flowers.

    Science.gov (United States)

    Acri-Nunes-Miranda, Roberta; Mondragón-Palomino, Mariana

    2014-01-01

    The diverse flowers of Orchidaceae are the result of several major morphological transitions, among them the most studied is the differentiation of the inner median tepal into the labellum, a perianth organ key in pollinator attraction. Type A peloria lacking stamens and with ectopic labella in place of inner lateral tepals are useful for testing models on the genes specifying these organs by comparing their patterns of expression between wild-type and peloric flowers. Previous studies focused on DEFICIENS- and GLOBOSA-like MADS-box genes because of their conserved role in perianth and stamen development. The "orchid code" model summarizes this work and shows in Orchidaceae there are four paralogous lineages of DEFICIENS/AP3-like genes differentially expressed in each floral whorl. Experimental tests of this model showed the conserved, higher expression of genes from two specific DEF-like gene lineages is associated with labellum development. The present study tests whether eight MADS-box candidate SEP-, FUL-, AG-, and STK-like genes have been specifically duplicated in the Orchidaceae and are also differentially expressed in association with the distinct flower organs of Phalaenopsis hyb. "Athens." The gene trees indicate orchid-specific duplications. In a way analogous to what is observed in labellum-specific DEF-like genes, a two-fold increase in the expression of SEP3-like gene PhaMADS7 was measured in the labellum-like inner lateral tepals of peloric flowers. The overlap between SEP3-like and DEF-like genes suggests both are associated with labellum specification and similar positional cues determine their domains of expression. In contrast, the uniform messenger levels of FUL-like genes suggest they are involved in the development of all organs and their expression in the ovary suggests cell differentiation starts before pollination. As previously reported AG-like and STK-like genes are exclusively expressed in gynostemium and ovary, however no evidence for

  1. Overcoming cisplatin resistance in non-small cell lung cancer with Mad2 silencing siRNA delivered systemically using EGFR-targeted chitosan nanoparticles.

    Science.gov (United States)

    Nascimento, Ana Vanessa; Singh, Amit; Bousbaa, Hassan; Ferreira, Domingos; Sarmento, Bruno; Amiji, Mansoor M

    2017-01-01

    Efficiency of chemotherapy is often limited by low therapeutic index of the drug as well as emergence of inherent and acquired drug resistance in cancer cells. As a common strategy to overcome drug resistance, higher doses of chemo-agents are administered. However, adverse side effects are usually increased as a consequence. A potentially effective approach is to combine chemotherapy with other therapeutic strategies such as small interfering RNAs (siRNAs) that allow the use of lower yet efficient doses of the anticancer drugs. We previously developed epidermal growth factor receptor (EGFR)-targeted chitosan (CS) nanoparticles as a versatile delivery system for silencing the essential mitotic checkpoint gene Mad2, and induce cell death. Here, we tested this system as a single therapy and in combination with cisplatin in cisplatin sensitive and resistant lung cancer models, and characterized its in vivo efficacy and safety. Combination treatment resulted in significant improvement in tumor inhibition that was strikingly more effective in cisplatin-resistant tumors. Importantly, effective cisplatin dosage was dramatically reduced in the co-therapy regimen resulting in negligible toxic effects from the drug as confirmed by parameters such as body weight gain, biochemical markers of hepatic and renal function, and histopathology of liver/kidney/spleen tissues. Overall, we demonstrate that the combination of Mad2 siRNA-loaded CS nanoparticles strategy with chemotherapeutic agents such as cisplatin constitutes an efficient and safe approach for the treatment of drug resistant tumors. Lung cancer remains one of the leading killers in the United States and around the world. Platinum agents, including cisplatin, are the first line treatment in lung cancer, including non-small cell lung cancer (NSCLC), which is the predominant form of lung cancer. In this study, we have evaluated Mad2 cell-cycle checkpoint gene silencing using small interfering RNA (siRNA) delivered

  2. Studies of tt+cc production with MadGraph5_aMC@NLO and Herwig++ for the ATLAS experiment

    CERN Document Server

    The ATLAS collaboration

    2016-01-01

    Studies of the simulation of ttcc at the LHC, at a centre-of-mass energy of 13 TeV, based on next-to-leading order calculations with MadGraph5_aMC@NLO matched to Herwig++ are presented. Samples with ttcc in the three flavour scheme, in a next-to-leading order matrix element are compared to an inclusive tt sample with the charm contribution coming from the parton shower. The effects of generator-level cuts, the functional form of the renormalization and factorization scales, and the starting scale of the parton shower are investigated.

  3. A loucura como questão semântica: uma interpretação kantiana Madness as a semantic question: a Kantian interpretation

    Directory of Open Access Journals (Sweden)

    Daniel Omar Perez

    2009-01-01

    Full Text Available Apesar das mudanças do projeto kantiano, é possível identificar o problema da loucura como sendo abordado em duas perspectivas: uma fisiológica, outra semântica. A abordagem fisiológica corresponde ao modelo das ciências dos objetos dos sentidos externos. Já a abordagem semântica da loucura se desenvolve dentro da tarefa crítica da filosofia, isto é, como parte de uma investigação acerca do alcance e dos limites da razão humana. Nesse sentido, a loucura se insere em duas séries diferentes. No primeiro caso aparece vinculada às lesões cerebrais, problemas de percepção ou até mesmo em relação ao consumo de substâncias que alteram o funcionamento físico. No segundo caso se relaciona com o entusiasmo do desvario profético, o fanatismo religioso, o misticismo e até mesmo a ilusão metafísica. Para desenvolver o nosso trabalho apresentaremos elementos da abordagem fisiológica e da abordagem semântica encontradas em alguns dos diferentes textos e, por último, realizaremos algumas considerações sobre a possibilidade do desenvolvimento de um saber sobre a loucura em Kant.Despite of the changes in the kantian project is possible to identify the problem of the madness as being boarded in two perspectives: 1. physiologic, 2. semantic. The physiologic approach corresponds to the model of the sciences about objects of the external senses. The semantic approach of the madness develops inside of the critical task of the philosophy, that is, as part of an investigation concerning the reach and the limits of the human reason. In this sense, the madness is in two different series. In the first case it appears entailed to the cerebral lesions, problems of perception or with the consumption of substances that change the physical operation. In the second case it relates with enthusiasm prophetic, the religious fanaticism, mysticism and even with the metaphysic. To develop our work here will present elements of the physiologic approach

  4. Addendum to the Closure Report for Corrective Action Unit 113: Area 25 R-MAD Facility, Nevada National Security Site, Nevada

    International Nuclear Information System (INIS)

    2011-01-01

    This addendum to the Closure Report for Corrective Action Unit 113: Area 25, Reactor Maintenance, Assembly, and Disassembly Facility, Building 3110, Nevada Test Site, Nevada, DOE/NV--891-VOL I-Rev. 1, dated July 2003, provides details of demolition, waste disposal, and use restriction (UR) modification for Corrective Action Unit 113, Area 25 R-MAD Facility. Demolition was completed on July 15, 2010, when the last of the building debris was disposed. Final field activities were concluded on August 30, 2010, after all equipment was demobilized and UR signs were posted. This work was funded by the American Recovery and Reinvestment Act.

  5. A Novel Sucrose-Regulatory MADS-Box Transcription Factor GmNMHC5 Promotes Root Development and Nodulation in Soybean (Glycine max [L.] Merr.

    Directory of Open Access Journals (Sweden)

    Wei Liu

    2015-08-01

    Full Text Available The MADS-box protein family includes many transcription factors that have a conserved DNA-binding MADS-box domain. The proteins in this family were originally recognized to play prominent roles in floral development. Recent findings, especially with regard to the regulatory roles of the AGL17 subfamily in root development, have greatly broadened their known functions. In this study, a gene from soybean (Glycine max [L.] Merr., GmNMHC5, was cloned from the Zigongdongdou cultivar and identified as a member of the AGL17 subfamily. Real-time fluorescence quantitative PCR analysis showed that GmNMHC5 was expressed at much higher levels in roots and nodules than in other organs. The activation of expression was first examined in leaves and roots, followed by shoot apexes. GmNMHC5 expression levels rose sharply when the plants were treated under short-day conditions (SD and started to pod, whereas low levels were maintained in non-podding plants under long-day conditions (LD. Furthermore, overexpression of GmNMHC5 in transgenic soybean significantly promoted lateral root development and nodule building. Moreover, GmNMHC5 is upregulated by exogenous sucrose. These results indicate that GmNMHC5 can sense the sucrose signal and plays significant roles in lateral root development and nodule building.

  6. A STE12 homologue of the homothallic ascomycete Sordaria macrospora interacts with the MADS box protein MCM1 and is required for ascosporogenesis.

    Science.gov (United States)

    Nolting, Nicole; Pöggeler, Stefanie

    2006-11-01

    The MADS box protein MCM1 controls diverse developmental processes and is essential for fruiting body formation in the homothallic ascomycete Sordaria macrospora. MADS box proteins derive their regulatory specificity from a wide range of different protein interactions. We have recently shown that the S. macrospora MCM1 is able to interact with the alpha-domain mating-type protein SMTA-1. To further evaluate the functional roles of MCM1, we used the yeast two-hybrid approach to identify MCM1-interacting proteins. From this screen, we isolated a protein with a putative N-terminal homeodomain and C-terminal C2/H2-Zn2+ finger domains. The protein is a member of the highly conserved fungal STE12 transcription factor family of proteins and was therefore termed STE12. Furthermore, we demonstrate by means of two-hybrid and far western analysis that in addition to MCM1, the S. macrospora STE12 protein is able to interact with the mating-type protein SMTA-1. Unlike the situation in the closely related heterothallic ascomycete Neurospora crassa, deletion (Delta) of the ste12 gene in S. macrospora neither affects vegetative growth nor fruiting body formation. However, ascus and ascospore development are highly impaired by the Deltaste12 mutation. Our data provide another example of the functional divergence within the fungal STE12 transcription factor family.

  7. Safety assessment document for spent fuel handling, packaging, and storage demonstrations at the E-MAD facility on the Nevada Test Site

    International Nuclear Information System (INIS)

    1985-04-01

    The objectives for spent fuel handling and packaging demonstration are to develop the capability to satisfactorily encapsulate typical commercial nuclear reactor spent fuel assemblies and to establish the suitability of interim dry surface and near surface storage concepts. To accomplish these objectives, spent fuel assemblies from a pressurized water reactor have been received, encapsulated in steel canisters, and emplaced in on-site storage facilities and subjected to other tests. As an essential element of these demonstrations, a thorough safety assessment of the demonstration activities conducted at the E-MAD facility has been completed. This document describes the site location and characteristics, the existing E-MAD facility, and the facility modifications and equipment additions made specifically for the demonstrations. The document also summarizes the Quality Assurance Program utilized, and specifies the principal design criteria applicable to the facility modifications, equipment additions, and process operations. Evaluations have been made of the radiological impacts of normal operations, abnormal operations, and postulated accidents. Analyses have been performed to determine the affects on nuclear criticality safety of postulated accidents and credible natural phenomena. The consequences of postulated accidents resulting in fission product gas release have also been estimated. This document identifies the engineered safety features, procedures, and site characteristics that (1) prevent the occurrence of potential accidents or (2) assure that the consequences of postulated accidents are either insignificant or adequately mitigated

  8. Corrective Action Decision Document for Corrective Action Unit 254: Area 25 R-MAD Decontamination Facility, Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    2000-01-01

    This Corrective Action Decision Document identifies and rationalizes the US Department of Energy, Nevada Operations Office's selection of a recommended corrective action alternative (CAA) appropriate to facilitate the closure of Corrective Action Unit (CAU) 254, R-MAD Decontamination Facility, under the Federal Facility Agreement and Consent Order. Located in Area 25 at the Nevada Test Site in Nevada, CAU 254 is comprised of Corrective Action Site (CAS) 25-23-06, Decontamination Facility. A corrective action investigation for this CAS as conducted in January 2000 as set forth in the related Corrective Action Investigation Plan. Samples were collected from various media throughout the CAS and sent to an off-site laboratory for analysis. The laboratory results indicated the following: radiation dose rates inside the Decontamination Facility, Building 3126, and in the storage yard exceeded the average general dose rate; scanning and static total surface contamination surveys indicated that portions of the locker and shower room floor, decontamination bay floor, loft floor, east and west decon pads, north and south decontamination bay interior walls, exterior west and south walls, and loft walls were above preliminary action levels (PALs). The investigation-derived contaminants of concern (COCs) included: polychlorinated biphenyls, radionuclides (strontium-90, niobium-94, cesium-137, uranium-234 and -235), total volatile and semivolatile organic compounds, total petroleum hydrocarbons, and total Resource Conservation and Recovery Act (Metals). During the investigation, two corrective action objectives (CAOs) were identified to prevent or mitigate human exposure to COCs. Based on these CAOs, a review of existing data, future use, and current operations at the Nevada Test Site, three CAAs were developed for consideration: Alternative 1 - No Further Action; Alternative 2 - Unrestricted Release Decontamination and Verification Survey; and Alternative 3 - Unrestricted

  9. La locura en la obra de Lacan: articulaciones con las nociones de cuerpo, manía y sexuación Madness in the Lacan work's: joints with the body, mania and sexuation

    Directory of Open Access Journals (Sweden)

    Pablo D. Muñoz

    2009-12-01

    Full Text Available En este artículo se presentan algunos avances del proyecto de investigación P601 (2008-2010: "Variaciones del concepto de locura en la obra de J. Lacan. Su incidencia en el diagnóstico diferencial neurosis-psicosis". Con el objetivo de avanzar en la precisión de la formalización del concepto de locura en la enseñanza de Lacan, su traducción en términos clínicos, y ponderar el modo en que dicha formalización reordena las concepciones de la locura desplegadas anteriormente en la psiquiatría y el psicoanálisis, indagamos aquí la relación de la locura con los conceptos de cuerpo, manía y sexuación.We present in this work the state and forward of the project UBACyT 2008-2010 (P601: "Variations of the concept of madness in the work of J. Lacan. Its incidence in the diagnosis differential neurosis-psychosis". With the goal of specify the formalization of the madness concept in Lacan's work, its translation in clinical terms, and analyse the way in which this formalization reorganizes the previous conceptions of madness developed in psychiatry and psychoanalysis, we investigate here the relation of madness with the concepts of body, mania and sexuation.

  10. CERN : Nouveaux records lors d'une période d'exploitation au PS/SPS ; Un nouveau rôle pour les ISR ; Deuxième région d'intersection pour le système pp du SPS ; Détermination de la durée de vie du charme ; Calcul en Sicile et au CERN

    CERN Multimedia

    1979-01-01

    CERN : Nouveaux records lors d'une période d'exploitation au PS/SPS ; Un nouveau rôle pour les ISR ; Deuxième région d'intersection pour le système pp du SPS ; Détermination de la durée de vie du charme ; Calcul en Sicile et au CERN

  11. Ratings Behaving Madly

    DEFF Research Database (Denmark)

    McCutcheon, Marion; Jensen, Pia Majbritt

    that of SBS’s total annual share for people aged 16 years and over, which grew at an average 0.4 per cent over the same time period. As well as attracting a growing audience, Danish dramas also tend to attract larger audiences than other foreign language dramas on SBS although they do not, of course, come...... occupied increasing amounts of screen time on Australian SBS’s television broadcast service, and attracted a growing audience, making Danish drama a vibrant offering in mainstream television in Australia. Australia and SBS thus stand out as the only country/broadcaster outside of Denmark’s wider geo...

  12. ["Stealing madness"--kleptomania].

    Science.gov (United States)

    Polak, D M; Dannon, P N

    2001-06-01

    Kleptomania is one of the common less diagnosed impulse control disorders, which could be treated by the combination of psychological and pharmacological therapy. The most effective treatment regimens include cognitive behavioral therapy and interpersonal psychotherapy in the psychological field, and antidepressants and mood stabilizers as pharmacological treatment. Most of the patients with kleptomania are initially treated only for a comorbid psychiatric disorder, since kleptomaniac symptoms had not been raised in the anamnesis. The aim of our article is to inform the physicians about the possible diagnosis and treatment options for this disorder in order to prevent co-morbidity with other psychiatric disorders. Some specific cases are presented in order to explain symptomatology.

  13. M.A.D

    DEFF Research Database (Denmark)

    Kacunko, Slavko

    2009-01-01

    This essay seeks to delineate the possible mutual benefits that different disciplines such as art history, media studies, computer science, etc. might derive from their specific efforts at formulating requirements and strategies for the appraisal of records and data as well as scientific and othe...

  14. Atraktsioon atraktsioonis / Madli Vitismann

    Index Scriptorium Estoniae

    Vitismann, Madli, 1950-

    2013-01-01

    Teadlaste öö Eesti Meremuuseumis uuris meremeeste hingeelu: vaadata sai näitust "Soolase elu kirjad", Professor Mati Heidmets vestles amatööreksperdi Marko Matverega ruumipsühholoogiast, Teadusajakirjanike Selts andis üle ajakirjandussõbralikuma teadlase auhinna "Ökul" Tarmo Soomerele. Paksus Margaretas saab vaadata laevapostkaartide näitust soome koguja Keijo Polóni kogust ja Lennusadamas USA näituseproduktsioonifirma Premier Exhibitionsi näitust "Titanic"

  15. Marijuana and madness

    National Research Council Canada - National Science Library

    Castle, David J; Murray, Robin, MD, M Phil, MRCP, MRC Psych; D'Souza, Deepak Cyril

    2012-01-01

    .... Effects of cannabis on mood are reviewed, as are its effects on cognition. This new edition has been extensively updated and expanded with 10 new chapters to incorporate major new research findings. This book will be of interest to all members of the mental health team, as well as to neuroscientists, epidemiologists, public health specialists and those involved in drug and alcohol research"--

  16. Normaalsuse uuringud / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2010-01-01

    24.-27. septembrini Slovakkias Nitras toimunud rahvusvahelisest teatrifestivalist "Divadelna Nitra 2010". Pikemalt Dmitri Krõmovi lavastusest "Oopus nr 7", tantsulavastusest "Out of Context: For Pina" ("Kontekstist väljas, Pinale") koreograaf Alain Plateli trupi Les Ballets C de la B esituses ja Christoph Willibald Glucki ooperist "Orpheus ja Eurydike" Mariusz Trelinski lavastuses

  17. Women, 'madness' and exercise.

    Science.gov (United States)

    Hardes, Jennifer Jane

    2018-03-21

    The positive relationship between exercise and mental health is often taken for granted in today's society, despite the lack of academic literature evidencing this symbiosis. Gender is considered a significant determinant in a number of mental health diagnoses. Indeed, women are considered twice as likely as men to experience the most pervasive mental health condition, depression. Exercise for women's mental health is promoted through various macrolevel charity, as well as microlevel, campaigns that influence government healthcare policy and National Health Service guidelines. Indeed, 'exercise prescriptions' in the treatment of depression is not uncommon. Yet, this link between exercise as a treatment for women's mental health has not always been so pervasive. In fact, an examination of asylum reports and medical journals from the late 19th century highlights a significant shift in attitude towards the role of exercise in the treatment of women's emotional states and mental health. This paper specifically examines how this treatment of women's mental health through exercise has moved from what might be regarded as a focus on exercise as a 'cause' of women's mental ailments to exercise promoted as a 'cure'. Unpacking the changing medical attitudes towards exercise for women in line with larger sociopolitical and historic contexts reveals that while this shift towards exercise promotion might prima facie appear as a less essentialist view of women and their mental and physical states, it inevitably remains tied to larger policy and governance agendas. New modes of exercise 'treatment' for women's mental health are not politically neutral and, thus, what appear to emerge as forms of liberation are, in actuality, subtler forms of regulation. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  18. Marijuana and madness

    National Research Council Canada - National Science Library

    Castle, David J; Murray, Robin, MD, M Phil, MRCP, MRC Psych; D'Souza, Deepak Cyril

    2012-01-01

    ...). It outlines the very latest developments in our understanding of the human cannabinoid system, and links this knowledge to clinical and epidemiological facts about the impact of cannabis on mental health...

  19. Madness, Dissidence and Transduction

    Directory of Open Access Journals (Sweden)

    Craig Stewart Walker

    2017-01-01

    Full Text Available El artista disidente ruso Piotr (o Petr Pavlensky recibió atención internacional luego de que en 2013 se transmitiera un video en el que aparecía sentado con los testículos clavados a los adoquines de la Plaza Roja de Moscú. Posteriormente, se reveló que el incidente hacía parte de una serie de acciones artísticas de Pavlensky, que incluyeron coserse la boca, aparecer desnudo dentro de un rollo de alambre de púas frente a la sede de la Asamblea Legislativa, construir una barrera de neumáticos en llamas en el centro de San Petersburgo, haciendo alusión a los levantamientos políticos en Kiev, cortarse su propia oreja mientras se sentaba desnudo en la pared del Hospital Psiquiátrico de Serbsky y prender fuego a las puertas de madera del cuartel general del Servicio Secreto ruso. Aunque las autoridades rusas han intentado en varias ocasiones tratar a Pavlensky como si estuviera criminalmente loco, él sigue defendiendo de manera articulada sus actividades como obras de arte político disidente. Este artículo explora la idea de que Pavlensky usa deliberadamente la transducción como una herramienta por medio de la cual su trabajo cobra sentido. Pavlensky invoca conscientemente dos campos diferentes de interpretación cultural. La primera es la adhesión de las autoridades al Código Penal ruso, que se utiliza para ejercer un control despótico sobre el pueblo ruso. El segundo es el discurso internacional que rodea el arte de vanguardia, que defiende la libertad de expresión, incluidas las obras disidentes. Al asegurar que hay una transducción de su trabajo desde el primer campo al segundo, Pavlensky crea una colisión de opinión en la que la legitimidad de la política estatal de Rusia es desafiada y deslegitimada.

  20. Marijuana and madness

    National Research Council Canada - National Science Library

    Castle, David J; Murray, Robin, MD, M Phil, MRCP, MRC Psych; D'Souza, Deepak Cyril

    2012-01-01

    .... Clinically focused chapters review not only the direct psychomimetic properties of cannabis, but also the impact consumption has on the courses of evolving or established mental illnesses such as schizophrenia...

  1. Constitutive expression of the K-domain of a Vaccinium corymbosum SOC1-like (VcSOC1-K) MADS-box gene is sufficient to promote flowering in tobacco.

    Science.gov (United States)

    Song, Guo-qing; Walworth, Aaron; Zhao, Dongyan; Hildebrandt, Britton; Leasia, Michael

    2013-11-01

    The K-domain of a blueberry-derived SOC1 -like gene promotes flowering in tobacco without negatively impacting yield, demonstrating potential for manipulation of flowering time in horticultural crops. The SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1) and SOC1-likes, belonging to the MIKC(c) (type II) MADS-box gene subfamily, are major floral activators and integrators of plant flowering. Both MADS-domains and K (Keratin)-domains are highly conserved in MIKC(c)-type MADS proteins. While there are many reports on overexpression of intact MIKC(c)-type MADS-box genes, few studies have been conducted to investigate the effects of the K-domains. In this report, a 474-bp K-domain of Vaccinium SOC1-like (VcSOC1-K) was cloned from the cDNA library of the northern highbush blueberry (Vaccinium corymbosum L.). Functional analysis of the VcSOC1-K was conducted by ectopically expressing of 35S:VcSOC1-K in tobacco. Reverse transcription PCR confirmed expression of the VcSOC1-K in T0 plants. Phenotypically, T1 transgenic plants (10 T1 plants/event) flowered sooner after seeding, and were shorter with fewer leaves at the time of flowering, than nontransgenic plants; but seed pod production of transgenic plants was not significantly affected. These results demonstrate that overexpression of the K-domain of a MIKC(c)-type MADS-box gene alone is sufficient to promote early flowering and more importantly without affecting seed production.

  2. Examination using LC-MS/MS determination of grayanotoxin levels in blood, urine, and honey consumed by patients presenting to the emergency department with mad honey intoxication and relations with clinical data: a preliminary study.

    Science.gov (United States)

    Aygun, Ali; Gunduz, Abdulkadir; Turedi, Suleyman; Turkmen, Suha; Karaca, Yunus; Ayaz, Faik Ahmet; Ahn, Su Youn; Kim, Suncheun

    2015-01-01

    Intoxications related to "mad honey" are frequently encountered in the Black Sea region of Turkey. Intoxication is established on the basis of whether honey was consumed when history was taken at presentation. The search for a simple and reliable method for showing the grayanotoxins (GTXs) in mad honey in body fluids and in honey consumed by patients is still at the research stage. The purpose of this preliminary study was to investigate GTX levels in blood, urine, and honey consumed by patients with mad honey intoxication and to determine whether there is an association with clinical status. This descrptive study was conducted at the department of Emergency Medicine of Karadeniz Technical University Medical Faculty in Turkey. Mad honey, blood, and urine samples were obtained from patients between September 2013 and October 2014. Four cases presenting the Department of Emergency Medicine and diagnosed with mad honey intoxication were included in the study. GTX levels in blood, urine, and honey consumed by patients were determined using liquid chromatography-tandem mass spectrometry. Patients' mean blood GTX I level was 30.62 ng/mL, GTX III level 4.917 ng/mL, urine GTX I level 0.447 mg/mL, and GTX III level 1.998 mg/mL. The mean GTX I level in the honey samples consumed was 4.683 mg/g and GTX III level 8.423 mg/g. The present study is unique in representing the first time that GTXs have been determined in human body fluids. There is now an urgent need for a large series of studies to provide statistical evidence whether there is a relationship between levels of toxins in human body fluids and clinical picture.

  3. Neutral illusions, selective nightmares and autopoietic madness Ilusiones neutrales, pesadillas selectivas y locura autopoiética

    Directory of Open Access Journals (Sweden)

    CARLOS Y VALENZUELA

    2010-12-01

    Full Text Available Until now, there are three evolutionary models: I The Synthetic Theory of Evolution (STE also named as the Neo-Darwinian model; II The Neutral Theory of Evolution (NTE with its daughter the Nearly-Neutral Theory of Evolution (NNTE; III The Theory of Evolution by means of Natural Drift (NDTE (Valenzuela 2007, 2009. All these theories accept that variation of genomes of living beings emerges by mutation. They disagree in relation of the causes of the acquisition and maintenance of the living being organization. STE proposes that the main factor for the acquisition and maintenance of fixated organization is selection and a marginal role of genetic drift. NTE proposed that the acquisition and maintenance of fixated organization is drift with a marginal role of selection, its daughter the NNTE includes besides selection with coefficients similar to the mutation rates. NDTE is derived from the conception of living beings as autopoietic processes, thus the acquisition and maintenance of organization occur by natural drift and living beings are always adapted. The extreme importance given to the factors of evolution, within each theory, has lead to absurd exaggerations that seems now illusions, nightmares or simply madness.Hasta el presente existen tres modelos evolutivos: I la Teoría Sintéti ca de la Evolución, (STE también conocida como modelo Neodarwiniano; II La Teoría Neutral de la Evolución (NTE con su hija la Teoría Casi-Neutral de la Evolución (NNTE; III La Teoría de la Evolución por Deriva Natural (NDTE. Todas las teorías aceptan que la variación genómica ocurre por mutación, pero discrepan en la importancia de los factores que llevan a la adquisición y mantención de la organización del ser vivo. La STE establece que el factor principal de la adquisición y mantención de los caracteres es la selección natural y concede un rol marginal a la deriva genética. La NTE establece que el factor principal de adquisición y mantenci

  4. ‘I am not very well I feel nearly mad when I think of you’: Male Jealousy, Murder and Broadmoor in Late-Victorian Britain

    Science.gov (United States)

    Shepherd, Jade

    2017-01-01

    Abstract This article compares the representations of jealousy in popular culture, medical and legal literature, and in the trials and diagnoses of men who murdered or attempted to murder their wives or sweethearts before being found insane and committed into Broadmoor Criminal Lunatic Asylum between 1864 and 1900. It is shown that jealousy was entrenched in Victorian culture, but marginalised in medical and legal discourse and in the courtroom until the end of the period, and was seemingly cast aside at Broadmoor. As well as providing a detailed examination of varied representations of male jealousy in late-Victorian Britain, the article contributes to understandings of the emotional lives of the working-class, and the causes and representations of working-class male madness. PMID:29713114

  5. 'I am not very well I feel nearly mad when I think of you': Male Jealousy, Murder and Broadmoor in Late-Victorian Britain.

    Science.gov (United States)

    Shepherd, Jade

    2017-05-01

    This article compares the representations of jealousy in popular culture, medical and legal literature, and in the trials and diagnoses of men who murdered or attempted to murder their wives or sweethearts before being found insane and committed into Broadmoor Criminal Lunatic Asylum between 1864 and 1900. It is shown that jealousy was entrenched in Victorian culture, but marginalised in medical and legal discourse and in the courtroom until the end of the period, and was seemingly cast aside at Broadmoor. As well as providing a detailed examination of varied representations of male jealousy in late-Victorian Britain, the article contributes to understandings of the emotional lives of the working-class, and the causes and representations of working-class male madness.

  6. Computing decay rates for new physics theories with FeynRules  and MadGraph 5 _aMC@NLO

    CERN Document Server

    Alwall, Johan; Fuks, Benjamin; Mattelaer, Olivier; Öztürk, Deniz Gizem; Shen, Chia-Hsien

    2015-01-01

    We present new features of the FeynRules and MadGraph5/aMC@NLO programs for the automatic computation of decay widths that consistently include channels of arbitrary final-state multiplicity. The implementations are generic enough so that they can be used in the framework of any quantum field theory, possibly including higher-dimensional operators. We extend at the same time the conventions of the Universal FeynRules Output (or UFO) format to include decay tables and information on the total widths. We finally provide a set of representative examples of the usage of the new functions of the different codes in the framework of the Standard Model, the Higgs Effective Field Theory, the Strongly Interacting Light Higgs model and the Minimal Supersymmetric Standard Model and compare the results to available literature and programs for validation purposes.

  7. Un nouveau signalement de plante du Liban

    Directory of Open Access Journals (Sweden)

    Georges Tohmé

    2016-12-01

    Full Text Available Tohmé, G. and Tohmé, H. 2016. A new plant species in Lebanon. Lebanese Science Journal, 17(2: 240-241. In this note, the authors give a description of an Iris from Lebanon cited previously from Syria by Mouterde. They have named it, in 2014, I. persica tauri.

  8. Un nouveau directeur pour le Cern

    CERN Multimedia

    2002-01-01

    CERN's Council, in which the 20 Member States are represented and choose scientific program and decide financial means, held its 123nd session; the appointment of the next Director General, basic plan for 2003-2010 and a new status for non-european countries were among the subjects dealt and accepted (½ page)

  9. Description d'un nouveau brûleur compact. Fonctionnement en régime de gaz prémélangés Description of a New Compact Premixed Gas Burner

    Directory of Open Access Journals (Sweden)

    Minetti R.

    2006-11-01

    Full Text Available On décrit un nouveau brûleur compact à gaz, de haut rendement et d'une puissance variable de 1 à 5 kW. La source de chaleur est une flamme plate d'un prémélange stoechiométrique de gaz naturel et d'air stabilisé sur une grille d'une surface de 100 cm2. Plusieurs grilles en acier inoxydable sont comparées. Elles diffèrent par leur épaisseur, le nombre et la dimension des trous. Un échangeur de chaleur en laiton à circulation d'eau peut être approché jusqu'à 7 mm de la surface du brûleur. La température des gaz frais, le débit et la position de l'échangeur ont été modifiés et les conditions optimales de fonctionnement sont décrites. Les températures à travers les gaz frais, la flamme, les gaz brûlés et les fumées, ont été mesurées. Un modèle simple des échanges de chaleurs est présenté. Il permet une meilleure compréhension des processus de transfert et facilite le choix des conditions opératoires. Dans les meilleures conditions, 93 % du contenu thermique du mélange gazeux est transféré à l'échangeur. Some general characteristics of a compact and efficient gas burner are described (1-5 kW. The heat source is a premixed flat flame stabilized on a 100 cm2 grid fed by a stoechiometric mixture of air and natural gas. Various types of stainless steel grids have been investigated. They differ according to their thickness and to the number and size of the holes. A circulating water heat exchanger made of brass can be approached to the flame as close as 7 mm above the burner surface. The temperature of the inlet gas mixture, the flow rate, and the position of the heat exchanger have been varied. The best working conditions are given as well as the temperature through the fresh gaseous mixture, the temperature profiles of the flame and the temperature of the fumes. From heat transfer calculations a simple model is presented. It gives better insight into the heat transfer processes and facilitates a judicious

  10. The DAL10 gene from Norway spruce (Picea abies) belongs to a potentially gymnosperm-specific subclass of MADS-box genes and is specifically active in seed cones and pollen cones.

    Science.gov (United States)

    Carlsbecker, Annelie; Sundström, Jens; Tandre, Karolina; Englund, Marie; Kvarnheden, Anders; Johanson, Urban; Engström, Peter

    2003-01-01

    Transcription factors encoded by different members of the MADS-box gene family have evolved central roles in the regulation of reproductive organ development in the flowering plants, the angiosperms. Development of the stamens and carpels, the pollen- and seed-bearing organs, involves the B- and C-organ-identity MADS-box genes. B- and C-type gene orthologs with activities specifically in developing pollen- and seed-bearing organs are also present in the distantly related gymnosperms: the conifers and the gnetophytes. We now report on the characterization of DAL10, a novel MADS-box gene from the conifer Norway spruce, which unlike the B- and C-type conifer genes shows no distinct orthology relationship to any angiosperm gene or clade in phylogenetic analyses. Like the B- and C-type genes, it is active specifically in developing pollen cones and seed cones. In situ RNA localization experiments show DAL10 to be expressed in the cone axis, which carry the microsporophylls of the young pollen cone. In contrast, in the seed cone it is expressed both in the cone axis and in the bracts, which subtend the ovuliferous scales. Expression data and the phenotype of transgenic Arabidopsis plants expressing DAL10 suggest that the gene may act upstream to or in concert with the B- and C-type genes in the establishment of reproductive identity of developing cones.

  11. Reply to Mas et al.: Comment on Gebhardt et al. MAD-MEX: Automatic Wall-to-Wall Land Cover Monitoring for the Mexican REDD-MRV Program Using All Landsat Data. Remote Sens. 2014, 6, 3923–3943

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    Michael Schmidt

    2016-06-01

    Full Text Available Mas, J.F. et al. have submitted a paper [1] for publication, which aims to respond to a paper published by Gebhardt et al. [2]. Mas, J.F. et al. had received a consultancy in 2013 to assess the quality of the early prototype products partly described in Gebhardt et al. in 2014. This consultancy, although a formal non-disclosure agreement had not been demanded, was awarded under the mutual understanding that the data handed over to Mas et al. constitute the early development phase of the program. Therefore, Mas et al. had been asked to give an assessment on the quality of the prototypes to obtain a proof of concept for the proposed workflow of MAD-Mex. It was clear that this assessment would suffer from limited availability of high quality training and validation data available in 2013. Mas et al. finally did not execute the consultancy due to the limited vector processing capacities in their lab. In October 2014, we sent the latest products, version 4.2 of the MAD-Mex products, including the more than 200,000 validation points gathered from independent expert interpreters of all Mexican ecosystems. Mas et al. did not respond to this transfer or to our request to collaborate in the quality control and assessment of MAD-Mex.

  12. “I’m in the Hospice, god”: problematizations about the madness, the hospice and the psychiatry in the diary of Maura Lopes Cançado (Brazil, 1959-60

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    Yonissa Wadi

    2017-12-01

    Full Text Available The writer Maura Lopes Cançado circulated in the world of the psychiatric hospitals between the 1950s, 1960s and 1970s. During one of hospitalizations (1959-1960, the third time in the National Psychiatric Center, a hospital complex in Rio de Janeiro, the writer wrote a diary that was later published as the book Hospice is God-Diary I. The bond between the live lived by her and the fiction, which the narrator transited in her diary, creating a unique work from the perspective of academic commentators and literary critics. In the history field of madness and psychiatry, this work offers new possibilities for understanding the configuration of psychiatric care, scientific and therapeutic practices and the various subjects that circulated in the world of Brazilians psychiatric hospitals, in the 1950s, operating a displacement in relation to traditional places of enunciation that are known. In this article, I chose to observe the problematizations of Maura about the institutional daily life and the fact of writing a diary, which oscillate between teaching others and the care of the self. Therefore, I did an enunciative analysis of the narrative, that values the things that were said by her as one of the truths about the psychiatric hospital, medical science and its practices, the mad and the madness.

  13. Aḥmad Muṣṭafā Ṭāshkubrīzāde’s (d. 968/1561 polemical tract against Judaism

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    Schmidtke, Sabine

    2008-06-01

    Full Text Available This article deals with a short polemical tract against Judaism written by the well-known Ottoman scholar Aḥmad Muṣṭafā Ṭāshkubrīzāde (d. 968/1560. The author uses the same arguments known to us from medieval polemics, viz. that the Torah, which was abrogated by Islam, contains references to the Prophet Muḥammad, despite the fact that it was tampered with by the Jews. In addition to the Bible, Ṭāshkubrīzāde quotes a number of later Jewish sources that add an important dimension to his tract. After a brief introduction in which the possibility of the author's indebtedness to Ibn Abī ‘Abd al-Dayyān, a Jewish convert to Islam, is discussed, an edition and translation of the text are provided.

    Este artículo estudia un corto tratado de polémica en contra del judaísmo escrito por el conocido erudito otomano Aḥmad Muṣṭafā Ṭāšhkubrīzāde (m. 968/1560. El autor utiliza los mismos argumentos que conocemos de la polémica religiosa medieval, tales como que la Torah, abrogada por el Islam, contenía referencias al Profeta Muḥammad a pesar de que su texto fue corrompido por los judíos. Además de la Biblia, Ṭāšhkubrīzāde cita una serie de fuentes judías tardías que añaden una importante dimensión a este trabajo. Después de una breve introducción en que se discute la posibilidad de la deuda del autor respecto a la obra de Ibn Abī ‘Abd al-Dayyān, un converso del judaísmo al Islam, se presenta una edición y traducción del texto.

  14. The regulatory mechanism of fruit ripening revealed by analyses of direct targets of the tomato MADS-box transcription factor RIPENING INHIBITOR

    Science.gov (United States)

    Fujisawa, Masaki; Ito, Yasuhiro

    2013-01-01

    The developmental process of ripening is unique to fleshy fruits and a key factor in fruit quality. The tomato (Solanum lycopersicum) MADS-box transcription factor RIPENING INHIBITOR (RIN), one of the earliest-acting ripening regulators, is required for broad aspects of ripening, including ethylene-dependent and -independent pathways. However, our knowledge of direct RIN target genes has been limited, considering the broad effects of RIN on ripening. In a recent work published in The Plant Cell, we identified 241 direct RIN target genes by chromatin immunoprecipitation coupled with DNA microarray (ChIP-chip) and transcriptome analysis. Functional classification of the targets revealed that RIN participates in the regulation of many biological processes including well-known ripening processes such as climacteric ethylene production and lycopene accumulation. In addition, we found that ethylene is required for the full expression of RIN and several RIN-targeting transcription factor genes at the ripening stage. Here, based on our recently published findings and additional data, we discuss the ripening processes regulated by RIN and the interplay between RIN and ethylene. PMID:23518588

  15. Functional and evolutionary analysis of the AP1/SEP/AGL6 superclade of MADS-box genes in the basal eudicot Epimedium sagittatum.

    Science.gov (United States)

    Sun, Wei; Huang, Wenjun; Li, Zhineng; Song, Chi; Liu, Di; Liu, Yongliang; Hayward, Alice; Liu, Yifei; Huang, Hongwen; Wang, Ying

    2014-03-01

    MADS-box transcriptional regulators play important roles during plant development. Based on phylogenetic reconstruction, the AP1/SEP/AGL6 superclade of floral MADS-box genes underwent one or two duplication events in the common ancestor of the core eudicots. However, the functional evolution of the AP1/SEP/AGL6 superclade in basal eudicots remains uncharacterized. Epimedium sagittatum is a basal eudicot species valued for its medicinal properties and showing unique floral morphology. In this study, structural and functional variation of FUL-like (AP1 subfamily), SEP-like and AGL6-like genes in this species was investigated to further our understanding of flower evolution in angiosperms. Detailed investigations into the microsynteny and evolutionary history of the floral A and E class MADS-box genes in eudicots were undertaken and used to trace their genomic rearrangements. One AP1-like gene, two SEP-like genes and one AGL6-like gene were cloned from E. sagittatum. Their expression patterns were examined using quantitative RT-PCR in different vegetative and reproductive organs at two developmental stages. Yeast two-hybrid assays were carried out among AP1/SEP/AGL6 superclade, AP3/PI and AGAMOUS subfamily members for elucidation of dimerization patterns. In addition, possible formation of a ternary complex involving B class proteins with the A class protein EsFUL-like, the E class SEP-like protein EsAGL2-1 or the AGL6-class protein EsAGL6 were detected using yeast three-hybrid assays. Transgenic Arabidopsis or tobacco plants expressing EsFUL-like, EsAGL2-1 and EsAGL6-like under the cauliflower mosaic virus (CaMV) 35S promoter were generated and analysed. Genomic studies of AP1 syntenic regions in arabidopsis, columbine, strawberry, papaya, peach, grapevine and tomato were conducted for microsyntenic analyses. Sequence and phylogenetic analyses showed that EsFUL-like is a member of the AP1 (A class) subfamily, EsAGL2-1 and EsAGL2-2 belong to the SEP-like (E class

  16. Swift J1644+57 gone MAD: the case for dynamically important magnetic flux threading the black hole in a jetted tidal disruption event

    Science.gov (United States)

    Tchekhovskoy, Alexander; Metzger, Brian D.; Giannios, Dimitrios; Kelley, Luke Z.

    2014-01-01

    The unusual transient Swift J1644+57 likely resulted from a collimated relativistic jet, powered by the sudden onset of accretion on to a massive black hole (BH) following the tidal disruption (TD) of a star. However, several mysteries cloud the interpretation of this event, including (1) the extreme flaring and `plateau' shape of the X-ray/γ-ray light curve during the first t - ttrig ˜ 10 d after the γ-ray trigger; (2) unexpected rebrightening of the forward shock radio emission at t - ttrig ˜ months; (3) lack of obvious evidence for jet precession, despite the misalignment typically expected between the angular momentum of the accretion disc and BH; (4) recent abrupt shut-off in the jet X-ray emission at t - ttrig ˜ 1.5 yr. Here, we show that all of these seemingly disparate mysteries are naturally resolved by one assumption: the presence of strong magnetic flux Φ• threading the BH. Just after the TD event, Φ• is dynamically weak relative to the high rate of fall-back accretion dot{M}, such that the accretion disc (jet) freely precesses about the BH axis = our line of sight. As dot{M} decreases, however, Φ• becomes dynamically important, leading to a state of `magnetically arrested disk' (MAD). MAD naturally aligns the jet with the BH spin, but only after an extended phase of violent rearrangement (jet wobbling), which in Swift J1644+57 starts a few days before the γ-ray trigger and explains the erratic early light curve. Indeed, the entire X-ray light curve can be fitted to the predicted power-law decay dot{M} ∝ t^{-α } (α ≃ 5/3 - 2.2) if the TD occurred a few weeks prior to the γ-ray trigger. Jet energy directed away from the line of sight, either prior to the trigger or during the jet alignment process, eventually manifests as the observed radio rebrightening, similar to an off-axis (orphan) γ-ray burst afterglow. As suggested recently, the late X-ray shut-off occurs when the disc transitions to a geometrically thin (jetless) state once

  17. Ifp's New Flexible Hydrocracking Process Combines Maximum Conversion with Production of High Viscosity, High Vi Lube Stocks Le nouveau procédé IFP d'hydrocraquage à haute flexibilité combine conversion maximum et production de bases, huile à haute viscosité et à indice de viscosité élevé

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    Hennico A.

    2006-11-01

    Full Text Available Institut Français du Pétrole (IFP has developed a new dual catalytic system for its hydrocracking process that enables high conversion to middle distillates and production of high viscosity, high VI lube stocks. Although the hydrocracking process is mainly devoted to the conversion of vacuum distillates, deasphalted oil or mixture of both into high quality middle distillates, it can also produce a residue, that after dewaxing will be a very high VI lube base oil. In this presentation major emphasis is put on the possibility to produce very high VI lubes with high viscosity thanks to the development of the new catalytic system. Large flexibility in feedstock selection and easy control of operating variables allow the production of all grades of lube oils associated with high quality middle distillates for a large range of conversion levels. L'Institut Français du Pétrole (IFP a mis au point, pour son procédé d'hydrocraquage, un nouveau système catalytique à 2 catalyseurs qui permet une forte conversion en distillats moyens et la production de fractions lubrifiantes à haute viscosité et indice de viscosité élevé. Si le procédé d'hydrocraquage est essentiellement utilisé pour la conversion de distillats sous vide, d'huile désasphaltée ou d'un mélange des deux en distillats moyens de haute qualité, il peut aussi produire un résidu qui, après déparaffinage, fournira une base pour lubrifiant à indice de viscosité très élevé. Cet article souligne particulièrement la possibilité de produire des lubrifiants à indice de viscosité très élevé et haute viscosité, grâce à ce nouveau système catalytique. Une grande flexibilité dans le choix des produits à traiter et la facilité de contrôle des paramètres opératoires permet la production de toutes les qualités d'huiles lubrifiantes associées à des distillats moyens de haute qualité, pour une large gamme de niveaux de conversion.

  18. Foucault, Derrida e a História da Loucura: notas sobre uma polêmica Foucault, Derrida, and the history of madness: notes on a controversy

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    André de Faria Pereira Neto

    1998-07-01

    Full Text Available A publicação do livro Folie et Déraison. Histoire de la Folie à l'âge Classique (1961, de Michel Foucault, promoveu um debate entre o autor e o filósofo Jacques Derrida, durante os anos 60/70. Derrida criticou a proposta metodológica e a organização da História da Loucura, apresentadas por Foucault, no prefácio da primeira edição. Essa polêmica parece ter motivado o autor a retirar, da segunda edição, o prefácio que abria a primeira versão do livro. O objetivo deste artigo é analisar alguns pontos presentes nesta controvérsia. Além disso, ele apresenta uma agenda de pesquisa para o entendimento das razões que levaram Foucault a tomar tal atitude.The publication of the book Folie et Déraison. Histoire de la Folie à l'âge Classique (1961, by Michel Foucault, sparked a debate between the author and philosopher Jacques Derrida during the 1960s and 70s. Derrida criticized the methodological proposal and organization of the History of Madness presented by Foucault in the foreword to the first edition. The controversy appears to have motivated the author to withdraw this same foreword from the second edition. The purpose of this article is to analyze some current points in this controversy. It also presents a research agenda for an understanding of the reasons leading Foucault to take this stance.

  19. Digital gene expression analysis of male and female bud transition in Metasequoia reveals high activity of MADS-box transcription factors and hormone-mediated sugar pathways.

    Science.gov (United States)

    Zhao, Ying; Liang, Haiying; Li, Lan; Tang, Sha; Han, Xiao; Wang, Congpeng; Xia, Xinli; Yin, Weilun

    2015-01-01

    Metasequoia glyptostroboides is a famous redwood tree of ecological and economic importance, and requires more than 20 years of juvenile-to-adult transition before producing female and male cones. Previously, we induced reproductive buds using a hormone solution in juvenile Metasequoia trees as young as 5-to-7 years old. In the current study, hormone-treated shoots found in female and male buds were used to identify candidate genes involved in reproductive bud transition in Metasequoia. Samples from hormone-treated cone reproductive shoots and naturally occurring non-cone setting shoots were analyzed using 24 digital gene expression (DGE) tag profiles using Illumina, generating a total of 69,520 putative transcripts. Next, 32 differentially and specifically expressed transcripts were determined using quantitative real-time polymerase chain reaction, including the upregulation of MADS-box transcription factors involved in male bud transition and flowering time control proteins involved in female bud transition. These differentially expressed transcripts were associated with 243 KEGG pathways. Among the significantly changed pathways, sugar pathways were mediated by hormone signals during the vegetative-to-reproductive phase transition, including glycolysis/gluconeogenesis and sucrose and starch metabolism pathways. Key enzymes were identified in these pathways, including alcohol dehydrogenase (NAD) and glutathione dehydrogenase for the glycolysis/gluconeogenesis pathway, and glucanphosphorylase for sucrose and starch metabolism pathways. Our results increase our understanding of the reproductive bud transition in gymnosperms. In addition, these studies on hormone-mediated sugar pathways increase our understanding of the relationship between sugar and hormone signaling during female and male bud initiation in Metasequoia.

  20. Digital gene expression analysis of male and female bud transition in Metasequoia reveals high activity of MADS-box transcription factors and hormone-mediated sugar pathways

    Directory of Open Access Journals (Sweden)

    Ying eZhao

    2015-06-01

    Full Text Available Metasequoiaglyptostroboidies is a famous redwood tree of ecological and economic importance, and requires more than 20 years of juvenile-to-adult transition before producing female and male cones. Previously, we induced reproductive buds using a hormone solution in juvenile Metasequoia trees as young as5-to-7years old. In the current study, hormone-treated shoots found in female and male buds were used to identify candidate genes involved in reproductive bud transition in Metasequoia. Samples from hormone-treated cone reproductive shoots and naturally occurring non-cone setting shoots were analyzed using 24 digital gene expression (DGE tag profiles using Illumina, generating a total of 69,520 putative transcripts. Next, 32 differentially and specifically expressed transcripts were determined using quantitative real-time polymerase chain reaction, including the upregulation of MADS-box transcription factors involved in male bud transition and flowering time control proteins involved in female bud transition. These differentially expressed transcripts were associated with 243 KEGG pathways. Among the significantly changed pathways, sugar pathways were mediated by hormone signals during the vegetative-to-reproductive phase transition, including glycolysis/gluconeogenesis and sucrose and starch metabolism pathways. Key enzymes were identified in these pathways, including alcohol dehydrogenase (NAD and glutathione dehydrogenase for the glycolysis/gluconeogenesis pathway, and glucanphosphorylase for sucrose and starch metabolism pathways. Our results increase our understanding of the reproductive bud transition in gymnosperms. In addition, these studies on hormone-mediated sugar pathways increase our understanding of the relationship between sugar and hormone signaling during female and male bud initiation in Metasequoia.

  1. Motherhood and the "Madness of Hunger": "...Want Almal Vra vir My vir 'n Stukkie Brood" ("...Because Everyone Asks Me for a Little Piece of Bread").

    Science.gov (United States)

    Kruger, Lou-Marié; Lourens, Marleen

    2016-03-01

    children can be thought of as evoking a kind of "madness" in low-income mothers.

  2. 3 dimensional distributions of NO2, CHOCHO, and HCHO measured by the University of Colorado 2D-MAX-DOAS during MAD-CAT

    Science.gov (United States)

    Ortega, Ivan; Sinreich, Roman; Volkamer, Rainer

    2014-05-01

    We present results of 2 dimensional Multi Axis-DOAS (2D-MAX-DOAS) measurements to infer 3-dimensional measurements of trace gases by characterizing boundary layer vertical profiles and near surface azimuth horizontal distribution of NO2 (14 angles covering 360°). We combine the established optimal estimation inversion with a new parameterization approach; the first method to derive NO2 tropospheric vertical profiles and boundary layer height and the second one to retrieve the azimuth horizontal distribution of near surface NO2 mixing ratios, both at multiple wavelengths (350 nm, 450 nm, and 560 nm). This was conducted for three cloud-free days in the framework of the intensive Multi Axis DOAS Comparison campaign for Aerosols and Trace gases (MAD-CAT) in Mainz, Germany 2013. By retrieving NO2 at multiple wavelengths range-resolved distributions of NO2 are derived using an 'Onion-peeling' approach, i.e., exploiting the fact that the optical path lengths at different wavelengths probe different horizontal air masses. We also measure glyoxal (CHOCHO) and formaldehyde (HCHO) distributions, and present to our knowledge the first 3-dimesional trace-gas distribution measurements of CHOCHO by a ground-based instrument. We expand the 2D-MAX-DOAS capabilities to calculate azimuth ratios of HCHO-to-NO2 (RFN) and CHOCHO-to-NO2 (RGN) to pinpoint volatile organic compound (VOC) oxidation chemistry and CHOCHO-to-HCHO (RGF) ratios as an indicator of biogenic and/or anthropogenic VOC emissions. The results of RFN correlate well with RGN and we identify azimuth variations that indicate gradients in the VOC/NOx chemistry that leads to O3 and secondary aerosol production. While there is a clear diurnal pattern in the RFN and RGN, no such variations are observed in the RGF, which shows rather constant values below 0.04 throughout the day, consistent with previous measurements, and indicative of urban air masses.

  3. Variations on a theme in fruit development: the PLE lineage of MADS-box genes in tomato (TAGL1) and other species.

    Science.gov (United States)

    Garceau, Danielle C; Batson, Megan K; Pan, Irvin L

    2017-08-01

    This article focuses on the role of TOMATO AGAMOUS-LIKE 1 (TAGL1) on a wide range of ripening functions in tomato. We also examine orthologs of this gene in related species that produce different fruit types and discuss some evolutionary implications. TOMATO AGAMOUS-LIKE 1 (TAGL1) is a MADS-box transcription factor gene that belongs to the PLENA (PLE) lineage within the AGAMOUS (AG) clade. The most well-studied genes in this lineage are the SHATTERPROOF (SHP) genes in Arabidopsis, known to be involved in dehiscence zone formation during silique development. In tomato, TAGL1 has been shown to control several aspects of tomato fruit ripening. Most notably, carotenoid synthesis seems to be controlled by TAGL1, likely via the ethylene synthesis and signaling pathway and in combination with RIPENING INHIBITOR (RIN). In addition, TAGL1 regulates genes involved in cell cycle regulation, flavonoid and lignin biosynthesis, and cuticle development. We discuss many of the genes in these different pathways that are likely controlled by TAGL1, directly or indirectly. We also examine the relationship of TAGL1 with known and putative interaction partners. PLE lineage genes have also been examined in other species such as Antirrhinum, Petunia, and Nicotiana and provide an interesting example of conservation and diversification of function in species that produce very different types of fleshy and dry fruits. The control of lignification may be a common mechanism for this group of genes. Lastly, we discuss future work needed to elucidate the TAGL1 regulatory pathway in tomato and to help better understand the functional diversification of genes in this lineage in related species.

  4. Cloning and Functional Analysis of MADS-box Genes, TaAG-A and TaAG-B, from a Wheat K-type Cytoplasmic Male Sterile Line

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    Wenlong Yang

    2017-06-01

    Full Text Available Wheat (Triticum aestivum L. is a major crop worldwide. The utilization of heterosis is a promising approach to improve the yield and quality of wheat. Although there have been many studies on wheat cytoplasmic male sterility, its mechanism remains unclear. In this study, we identified two MADS-box genes from a wheat K-type cytoplasmic male sterile (CMS line using homology-based cloning. These genes were localized on wheat chromosomes 3A and 3B and named TaAG-A and TaAG-B, respectively. Analysis of TaAG-A and TaAG-B expression patterns in leaves, spikes, roots, and stems of Chinese Spring wheat determined using quantitative RT-PCR revealed different expression levels in different tissues. TaAG-A had relatively high expression levels in leaves and spikes, but low levels in roots, while TaAG-B had relatively high expression levels in spikes and lower expression in roots, stems, and leaves. Both genes showed downregulation during the mononucleate to trinucleate stages of pollen development in the maintainer line. In contrast, upregulation of TaAG-B was observed in the CMS line. The transcript levels of the two genes were clearly higher in the CMS line compared to the maintainer line at the trinucleate stage. Overexpression of TaAG-A and TaAG-B in Arabidopsis resulted in phenotypes with earlier reproductive development, premature mortality, and abnormal buds, stamens, and stigmas. Overexpression of TaAG-A and TaAG-B gives rise to mutants with many deformities. Silencing TaAG-A and TaAG-B in a fertile wheat line using the virus-induced gene silencing (VIGS method resulted in plants with green and yellow striped leaves, emaciated spikes, and decreased selfing seed set rates. These results demonstrate that TaAG-A and TaAG-B may play a role in male sterility in the wheat CMS line.

  5. Functional conservation and divergence of four ginger AP1/AGL9 MADS-box genes revealed by analysis of their expression and protein-protein interaction, and ectopic expression of AhFUL gene in Arabidopsis.

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    Xiumei Li

    Full Text Available Alpinia genus are known generally as ginger-lilies for showy flowers in the ginger family, Zingiberaceae, and their floral morphology diverges from typical monocotyledon flowers. However, little is known about the functions of ginger MADS-box genes in floral identity. In this study, four AP1/AGL9 MADS-box genes were cloned from Alpinia hainanensis, and protein-protein interactions (PPIs and roles of the four genes in floral homeotic conversion and in floral evolution are surveyed for the first time. AhFUL is clustered to the AP1 lineage, AhSEP4 and AhSEP3b to the SEP lineage, and AhAGL6-like to the AGL6 lineage. The four genes showed conserved and divergent expression patterns, and their encoded proteins were localized in the nucleus. Seven combinations of PPI (AhFUL-AhSEP4, AhFUL-AhAGL6-like, AhFUL-AhSEP3b, AhSEP4-AhAGL6-like, AhSEP4-AhSEP3b, AhAGL6-like-AhSEP3b, and AhSEP3b-AhSEP3b were detected, and the PPI patterns in the AP1/AGL9 lineage revealed that five of the 10 possible combinations are conserved and three are variable, while conclusions cannot yet be made regarding the other two. Ectopic expression of AhFUL in Arabidopsis thaliana led to early flowering and floral organ homeotic conversion to sepal-like or leaf-like. Therefore, we conclude that the four A. hainanensis AP1/AGL9 genes show functional conservation and divergence in the floral identity from other MADS-box genes.

  6. Creutzfeldt-Jakob disease a case report, with special attention to the electroencephalogram in this disorder and to its possible relationships to kuru, scrapie and «mad cow disease»

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    A.H. Chapman

    1993-06-01

    Full Text Available A case of Creutzfeldt-Jakob disease in a 58-year-old Brazillian cattle rancher and businessman is presented. The EEG was normal, which is consistent with the fact that it was made during the first half of his illness; in a later stage suppression of normal rhythms by slow moderate voltage waves would be expected. The resemblances of kuru, scrapie and "mad cow disease» to C-J disease are discussed. In each of these 4 illnesses the patient or affected animal (scrapie and «mad cow disease" (a has a widespread spongiform encephalopathy and consequent dementia, myoclonic epilepsy and cerebellar and corticospinal symptoms, (b Each illness is caused by a virus (or virus-like organism called a PrP or prion which is unusually resistant to heat and entirely resistant to ultraviolet light and x-rays, (c This causative agent can be transmitted to other mammals by intracerebral injection or, in the proved cases of 3 of them, by the oral route. Unresolved questions about C-J disease include the following: Are C-J disease, kuru, scrapie and "mad cow disease" essentially similar illnesses caused by the same virus or by subtle variants of it? What is the incubation period of C-J disease, and does its virus exist for long periods of time in some asymptomatic persons, some of whom may never become neurologically ill? How does this virus enter the bodies of most persons with C-J disease, and why does the clinical disease characteristically occur only in middle age?

  7. Iatrogenia e exclusão social: a loucura como objeto do discurso científico no Brasil Iatrogeny and social exclusion: madness as an object of scientific discourse in Brazil

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    Luís Gustavo Vechi

    2004-12-01

    Full Text Available Este trabalho apresenta um retrospecto histórico sobre o discurso científico a respeito da loucura no Brasil, com destaque para a evolução das noções de doença mental e de iatrogenia. O discurso manicomial, eminentemente psiquiátrico, introduziu o gerenciamento científico da loucura, a partir do final do século XIX. De meados do século XX ao final da década de 80, o discurso da saúde mental, organizado pela Psiquiatria e por outras disciplinas, como a Psicanálise, a Sociologia e a Antropologia, sob a perspectiva biopsicossocial de compreensão do homem, representou uma nova tentativa de validar o gerenciamento científico da loucura. A partir do final da década de 80, foi introduzido o discurso da desinstitucionalização que, em vez de propor uma nova validação do discurso científico no gerenciamento da loucura, indicou a necessidade de sua (desconstrução: uma radical operação epistemológica de modificação de suas concepções, como a de doença mental.This paper presents a historical retrospective on the scientific discourse about madness in Brazil, emphasizing the evolution of the notions of mental disease and of iatrogeny. The manicomial discourse, produced by Psychiatry, has introduced the scientific management of madness since the end of the 19th century. From the middle of the 20th century until the end of 1980, the discourse of mental health, organized by Psychiatry and by other disciplines, such as Psychoanalysis, Sociology and Anthropology, using a biopsychossocial understanding of man, represented a new attempt to reinforce the scientific management of madness. At the end of 1980, the deinstitutionalization discourse was introduced and, instead of proposing a new validation for the scientific discourse on madness, it indicated the necessity of its (deconstruction: a radical epistemological operation to modify some of its main notions, such as the notion of the mental disease.

  8. The study of the distribution of Ca{sup 45} with time in the newborn rat by the autoradiography method at - 195 deg; Etude de la distribution du {sup 45}Ca en fonction du temps chez le rat nouveau-ne par la methode d'autoradiographie a -195 deg

    Energy Technology Data Exchange (ETDEWEB)

    Kellershohn, C; Pellerin, P [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1961-07-01

    Ca{sup 45} metabolism has been studied as a function of time by autoradiography at -195 deg. C in the new-born rat after sub-epidermal dorsal injected of 20 micro-curies per animal. This study confirms: 1) The existence of a rapidly exchangeable calcium bone fraction; 2) A considerable intestinal excretion of radio-calcium, much greater than the urinary elimination; 3) A gradual transfer of the activity for the long bones of the epiphyseal to the diaphyseal regions during growth, together with secondary modifications during ossification. (author) [French] Le metabolisme du {sup 45}Ca est etudie en fonction du temps par autoradiographie a -195 deg. C, chez le rat nouveau-ne apres injection sous-epidermique dorsale de 20 microcuries par animal. Cette etude confirme: 1) l'existence d'une fraction calcique osseuse rapidement echangeable; 2) une excretion intestinale considerable du radiocalcium, tres superieure a l'elimination urinaire; 3) un transfert progressif de l'activite pour les os longs des regions epiphysaires aux regions diaphysaires au cours de la croissance, ainsi que les remaniements secondaires au cours de l'ossification. (auteur)

  9. Negative cognitions about the self in patients with persecutory delusions: An empirical study of self-compassion, self-stigma, schematic beliefs, self-esteem, fear of madness, and suicidal ideation.

    Science.gov (United States)

    Collett, Nicola; Pugh, Katherine; Waite, Felicity; Freeman, Daniel

    2016-05-30

    There has been growing awareness of the high prevalence of negative cognitions about the self in patients with persecutory delusions, and it has been proposed that paranoid fears build upon these perceived vulnerabilities. This study aimed to investigate for the first time a wide range of different conceptualisations of the negative self, and to examine associations with suicidal ideation, in patients with persecutory delusions. Twenty-one patients with persecutory delusions and twenty-one non-clinical individuals completed measures relating to negative self cognitions. The delusions group also completed a measure of suicidal ideation. It was found that the patients with persecutory delusions had low self-compassion, low self-esteem, increased fears of being mad, beliefs of inferiority to others, negative self-schemas, and low positive self-schemas when compared to the non-clinical control group. The effect sizes (Cohen's d) were large, and the different conceptualisations of negative self cognitions were highly associated with one another. Self-stigma did not differ between the two groups. Furthermore, suicidal ideation was highly associated with low self-compassion, low self-esteem, fears of madness, and negative self-schema but not self-stigma. This study shows marked negative self cognitions in patients with persecutory delusions. These are likely to prove targets of clinical interventions, with patient preference most likely determining the best conceptualisation of negative self cognitions for clinicians to use. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  10. MAX-DOAS measurements of HONO slant column densities during the MAD-CAT campaign: inter-comparison, sensitivity studies on spectral analysis settings, and error budget

    Directory of Open Access Journals (Sweden)

    Y. Wang

    2017-10-01

    Full Text Available In order to promote the development of the passive DOAS technique the Multi Axis DOAS – Comparison campaign for Aerosols and Trace gases (MAD-CAT was held at the Max Planck Institute for Chemistry in Mainz, Germany, from June to October 2013. Here, we systematically compare the differential slant column densities (dSCDs of nitrous acid (HONO derived from measurements of seven different instruments. We also compare the tropospheric difference of SCDs (delta SCD of HONO, namely the difference of the SCDs for the non-zenith observations and the zenith observation of the same elevation sequence. Different research groups analysed the spectra from their own instruments using their individual fit software. All the fit errors of HONO dSCDs from the instruments with cooled large-size detectors are mostly in the range of 0.1 to 0.3  ×  1015 molecules cm−2 for an integration time of 1 min. The fit error for the mini MAX-DOAS is around 0.7  ×  1015 molecules cm−2. Although the HONO delta SCDs are normally smaller than 6  ×  1015 molecules cm−2, consistent time series of HONO delta SCDs are retrieved from the measurements of different instruments. Both fits with a sequential Fraunhofer reference spectrum (FRS and a daily noon FRS lead to similar consistency. Apart from the mini-MAX-DOAS, the systematic absolute differences of HONO delta SCDs between the instruments are smaller than 0.63  ×  1015 molecules cm−2. The correlation coefficients are higher than 0.7 and the slopes of linear regressions deviate from unity by less than 16 % for the elevation angle of 1°. The correlations decrease with an increase in elevation angle. All the participants also analysed synthetic spectra using the same baseline DOAS settings to evaluate the systematic errors of HONO results from their respective fit programs. In general the errors are smaller than 0.3  ×  1015 molecules cm−2, which is

  11. Suurte kunstnike teater? / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2008-01-01

    2.-18. maini Berliinis toimunud saksakeelse teatri esindusfestivalist "Theatertreffen 2008", mis toimus sel aastal neljakümne viiendat korda. Lavastustest: Simon Stephensi "Pornograafia" (lav. Sebastian Nübling), Signa Sorenseni ja Arthur Köstleri "Martha Rubini ilmumised", Stephan Kimmigi Schilleri-tõlgendus "Maria Stuart", Gerhart Hauptmanni "Rotid" (lav. Michael Thalheimer), Shakespeare "Hamlet" (lav. Jan Bosse), Christoph Marthaleri "Platz Mangel"

  12. Piirid ja piiritus / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2008-01-01

    23.-27. aprillini Poolas Krakowis toimunud 33. teatrifestivalist ""Krakowskie Reminiscencje Teatralne". Pikemalt etendustest: "Rashomon" (lav. Bernhard Mikeska, "mikeska:plus:blendwerk" - Šveitsi), "Little red (play): herstory" (lav. Nicola Nord, "andcompany&Co" - Saksamaa), "Fragile" (lav. Matjazh Pogajc, Teatr Mladinsko - Sloveenia)

  13. The Mad Fox Disease: Rabies.

    Science.gov (United States)

    Keller, Rosanne

    One of a series of instructional materials produced by the Literacy Council of Alaska, this booklet provides information about the control of rabies. Using both simplified sentence structure and vocabulary, it describes how rabies may be spread, its symptoms, its treatment, and ways it can be prevented. (FL)

  14. [Don Quijote, a lucid mad].

    Science.gov (United States)

    Alonso Fernández, Francisco

    2004-01-01

    The case of a 50-year-old hidalgo who believed to be transformed into a knight-errant named Don Quijote is a megalomaniac systematized delusion of transformation of the self, a delusion of metamorphosis in reference to the patient's own identity. The outward projection of this syndrome produces some delusional misidentifications of others, things and animals and include elements of a persecutory delusion which increase the grandiosity of the self. At the same time the hidalgo was maniac with a pathway of bipolar disorder. The phenomenon of donquijotismo is described as the defence of wasted causes and Sancho Panza as an illiterate Sócrates.

  15. Maailma suurim festival / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2008-01-01

    Edinburghis toimuvast rahvusvahelisest teatri- ehk etenduskunstide festivalist Fringe 2008, mis hõlmab sõnateatrit, ooperit, muusikali, kaasaegset tantsu, show-tantsu, balletti, erinevaid komöödiavorme jne. Pikemalt mõnest tantsuetendusest ja Ida-Euroopa programmist

  16. Kasv tuleb europrojektidest / Madli Kents

    Index Scriptorium Estoniae

    Kents, Madli

    2003-01-01

    Audiitorfirmade TOP 50 3. koht. Deloitte & Touche Eesti AS-i nõukogu esimehe Tiit Järve sõnul saavutas ettevõte konkurentsieelise europrojektide ja rahvusvahelise emafirma toetuse tõttu. Diagramm: Tänavu ootab ees parem tulemus. Kommenteerib Mati Nõmmiste

  17. Physics in a mad world

    CERN Document Server

    2016-01-01

    This book tells captivating stories of misadventures of two renowned theoretical physicists in the Soviet Union. The first part is devoted to Friedrich (Fritz) Houtermans, an outstanding Dutch–Austrian–German physicist who was the first to suggest that the source of stars' energy is thermonuclear fusion, and also made a number of other important contributions to cosmochemistry and geochemistry. In 1935, Houtermans, a German communist, in an attempt to save his life from Hilter's Gestapo, fled to the Soviet Union. He took up an appointment at the Kharkov Physico-Technical Institute, working there for two years with the Russian physicist Valentin P Fomin. In the Great Purge of 1937, Houtermans was arrested in December by the NKVD (Soviet Secret Police, KGB's predecessor). He was tortured, and confessed to being a Trotskyist plotter and German spy, out of fear of threats against his wife Charlotte. However, Charlotte had already escaped from the Soviet Union to Denmark, after which she went to England and fi...

  18. Mad Tea Party Cyclic Partitions

    Science.gov (United States)

    Bekes, Robert; Pedersen, Jean; Shao, Bin

    2012-01-01

    Martin Gardner's "The Annotated Alice," and Robin Wilson's "Lewis Carroll in Numberland" led the authors to put this article in a fantasy setting. Alice, the March Hare, the Hatter, and the Dormouse describe a straightforward, elementary algorithm for counting the number of ways to fit "n" identical objects into "k" cups arranged in a circle. The…

  19. Genèse du nouveau master « Histoire des sciences et techniques, humanités numériques et médiations culturelles » : de l'articulation entre la recherche et la formation au Centre François Viète de l'Université de Bretagne Occidentale

    Directory of Open Access Journals (Sweden)

    Chambon Gregory

    2014-01-01

    Full Text Available L'objet de cet article est de montrer comment la dynamique de création simultanée, à Brest et depuis 2008, d'une nouvelle équipe de recherche et d'un nouveau master recherche à distance en 2012 s'est traduit par une proposition originale de formation par la recherche. Nous détaillons les spécificités de cette dernière. D'une part, elle prend fortement appui sur des axes de recherches et des nouvelles méthodologies en histoire des sciences et des techniques, qui s'inspirent des travaux sur la culture matérielle et la compréhension des systèmes complexes. En outre, nous montrons que des questions de recherche et de formation y sont intégrées concernant le développement ou l'usage des outils numériques (web sémantique, réalité virtuelle ou augmentée, etc. pour la recherche en SHS et médiations culturelles. L'équipe de Brest s'inscrit de ce fait dans le champ des travaux de recherches en humanités numériques en très forte collaboration avec notamment des laboratoires d'informatique. Au travers des thématiques traitées, des méthodologies enseignées, d'une pédagogie universitaire basée sur une classe virtuelle ainsi que de la nature des différents partenaires qui y enseignent, nous montrons ainsi que le master en question constituent un laboratoire où il est possible d'expérimenter de nouvelles pratiques de formation par la recherche.

  20. Subverting Sanity by Madness --A Psychoanalysis of the Central Figures in Tender is the Night%疯癫对文明的颠覆——对《夜色温柔》主人公的精神分析

    Institute of Scientific and Technical Information of China (English)

    杨澜

    2012-01-01

    In the novel Tender is the Night, the hero and the heroine exchange their roles of patient and doctor, in- sanity and culture. The interchange between madness and normality is the keynote of the book, as well as a meta- phor. From the perspective of psychoanalysis, the interchange also echoes the complex relations between ego and id, those of domination and counter-strike, of control and break-off.%《夜色温柔》中的男女主人公完成了各自从医生到“疯子”与从病人到正常人的角色互换。疯癫即是小说的主题,也是重要隐喻。从心理分析的角度看,二人的关系接近本能与自我互相制约、互相对抗的关系。

  1. The Dermond vertical axis wind turbine : a suitable solution for remote sites; L'eolienne a axe vertical Dermond : une eolienne particulierement bien adaptee aux milieux isoles

    Energy Technology Data Exchange (ETDEWEB)

    Martel, P. [Genivar, Montreal, PQ (Canada); Dery, J. [Dermond Inc., Ada, MI (United States)

    2005-07-01

    A new prototype of a 100 kW truncated Darrieus type vertical axis wind turbine was put into service at the University of Quebec in Abitibi-Temiscamingue. The prototype was developed by Dermond Inc., a subsidiary of Mckenzie Bay International, and has been connected to the internal power distribution network at the University since October 2004. The Dermond turbine is well suited for isolated communities in northern Canada and is an important part of power management that competes with other small autonomous diesel powered systems. In addition to its simple and reliable mechanics, the innovative turbine is easy to install and maintain. It is omni-directional, and as such, is always oriented towards the wind. It is also equipped with an advanced electronic control system that addresses the problem of power quality in small autonomous networks. Since its installation, the prototype has met its performance targets and Dermond Inc. plans to market a new 200 kW wind turbine in 2006 with improved characteristics. Dermond Inc. is confident that this technology can penetrate the markets of remote areas, including northern communities and islands. This paper described the origins of the vertical axis technology and how Dermond Inc. improved upon it to include the possibility of integrating other energy sources or energy storage for additional power gains. 8 figs.

  2. The MADS Box Genes ABS, SHP1, and SHP2 Are Essential for the Coordination of Cell Divisions in Ovule and Seed Coat Development and for Endosperm Formation in Arabidopsis thaliana.

    Science.gov (United States)

    Ehlers, Katrin; Bhide, Amey S; Tekleyohans, Dawit G; Wittkop, Benjamin; Snowdon, Rod J; Becker, Annette

    2016-01-01

    Seed formation is a pivotal process in plant reproduction and dispersal. It begins with megagametophyte development in the ovule, followed by fertilization and subsequently coordinated development of embryo, endosperm, and maternal seed coat. Two closely related MADS-box genes, SHATTERPROOF 1 and 2 (SHP1 and SHP2) are involved in specifying ovule integument identity in Arabidopsis thaliana. The MADS box gene ARABIDOPSIS BSISTER (ABS or TT16) is required, together with SEEDSTICK (STK) for the formation of endothelium, part of the seed coat and innermost tissue layer formed by the maternal plant. Little is known about the genetic interaction of SHP1 and SHP2 with ABS and the coordination of endosperm and seed coat development. In this work, mutant and expression analysis shed light on this aspect of concerted development. Triple tt16 shp1 shp2 mutants produce malformed seedlings, seed coat formation defects, fewer seeds, and mucilage reduction. While shp1 shp2 mutants fail to coordinate the timely development of ovules, tt16 mutants show less peripheral endosperm after fertilization. Failure in coordinated division of the innermost integument layer in early ovule stages leads to inner seed coat defects in tt16 and tt16 shp1 shp2 triple mutant seeds. An antagonistic action of ABS and SHP1/SHP2 is observed in inner seed coat layer formation. Expression analysis also indicates that ABS represses SHP1, SHP2, and FRUITFUL expression. Our work shows that the evolutionary conserved Bsister genes are required not only for endothelium but also for endosperm development and genetically interact with SHP1 and SHP2 in a partially antagonistic manner.

  3. The MADS Box Genes ABS, SHP1, and SHP2 Are Essential for the Coordination of Cell Divisions in Ovule and Seed Coat Development and for Endosperm Formation in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Katrin Ehlers

    Full Text Available Seed formation is a pivotal process in plant reproduction and dispersal. It begins with megagametophyte development in the ovule, followed by fertilization and subsequently coordinated development of embryo, endosperm, and maternal seed coat. Two closely related MADS-box genes, SHATTERPROOF 1 and 2 (SHP1 and SHP2 are involved in specifying ovule integument identity in Arabidopsis thaliana. The MADS box gene ARABIDOPSIS BSISTER (ABS or TT16 is required, together with SEEDSTICK (STK for the formation of endothelium, part of the seed coat and innermost tissue layer formed by the maternal plant. Little is known about the genetic interaction of SHP1 and SHP2 with ABS and the coordination of endosperm and seed coat development. In this work, mutant and expression analysis shed light on this aspect of concerted development. Triple tt16 shp1 shp2 mutants produce malformed seedlings, seed coat formation defects, fewer seeds, and mucilage reduction. While shp1 shp2 mutants fail to coordinate the timely development of ovules, tt16 mutants show less peripheral endosperm after fertilization. Failure in coordinated division of the innermost integument layer in early ovule stages leads to inner seed coat defects in tt16 and tt16 shp1 shp2 triple mutant seeds. An antagonistic action of ABS and SHP1/SHP2 is observed in inner seed coat layer formation. Expression analysis also indicates that ABS represses SHP1, SHP2, and FRUITFUL expression. Our work shows that the evolutionary conserved Bsister genes are required not only for endothelium but also for endosperm development and genetically interact with SHP1 and SHP2 in a partially antagonistic manner.

  4. The identity of «the Muftī of Oran», Abū l-‘Abbās Aḥmad b. Abī Jum‘ah al-Maghrāwī al-Wahrānī (d. 917/1511

    Directory of Open Access Journals (Sweden)

    Stewart, Devin

    2006-12-01

    Full Text Available This study attempts to identify the “muftī of Oran”, outlining his life and career through an analysis of the available data in North African sources. I suggest that already in the biographical sources of sixteenth century, the biographies of two scholars were conflated, that of the muft himself, Abū l-‘Abbās Aḥmad b. Abī Ŷum‘a (m. 917/1511, and that of his son, Abū ‘Abd Allāh Muḥammad Šaqrūn (d. 929/1523-24. This study endeavors to resolve this conflation. Originally from Oran, Aḥmad studied in Tlemcen and eventually settled in Fez, where he obtained a position as professor of Islamic law. It is likely that he issued his famous fatwā of 910/1504 to the Moriscos there, as one of the prominent jurists of the city, intending to oppose the opinion of his contemporary Aḥmad b. Yaḥyà al- Wanšarīsī (d. 914/1508.

    Esta investigación intenta identificar al “muftí de Orán,” bosquejando su vida y carrera a través de un análisis de los datos disponibles en las fuentes norteafricanas. Quisiera plantear que, ya en las fuentes biográficas del siglo XVI, se han confundido las biografías de dos eruditos, la del muftí, Abū l-‘Abbās Aḥmad b. Abī Ŷum‘a (m. 917/1511, y la de su hijo, Abū ‘Abd Allāh Muḥammad Šaqrūn (m. 929/1523-24. Mi investigación propone resolver esta confusión. Originario de Orán, Aḥmad estudió en Tremecén y acabó por establecerse en Fez, donde consiguió un puesto como profesor de ley islámica. Es probable que haya emitido su famosa fatwā de 910/1504 a los moriscos desde allá, como uno de los juristas prominentes de la ciudad, con la intención de oponerse a la opinión de su contemporáneo Aḥmad b. Yaḥyà al- Wanšarīsī (m. 914/1508.

  5. Imágenes de la locura en la Edad Moderna: escarnio y máscara en el discurso del poder = Images of Madness in the Modern Age: Derision and Mask in the Discourse of the Power

    Directory of Open Access Journals (Sweden)

    Manuel Gil Desco

    2016-05-01

    Full Text Available A finales del siglo XV el tema de la locura irrumpió en el relato del poder a través de varios discursos que utilizaron como elementos retóricos de expresión imágenes textuales y visuales muy heterogéneas. Dichos discursos procedían del ámbito médico, jurídico, social y político, y también del crítico reformista y del religioso contrarreformista. El presente trabajo intenta analizar cómo se configuraron estos discursos desde la dialéctica entre la categoría iconográfica que adquirió el loco en dichas imágenes y como se mostró este en la vida real. El trabajo se centra en el análisis de su peculiar indumentaria: el traje de escarnio identificativo del hospital al que estaba adscrito, y los vestidos de máscara del bufón y botarga. Desde tal presupuesto, planteamos una incursión en los mecanismos que convirtieron a la representación visual y textual del loco en un topos con dimensión moralizante sumamente útil como herramienta pedagógica para adoctrinar a las clases populares urbanas iletradas.In the late fifteenth century the theme of folly broke into the narration of power through various narratives that used different textual expressions and visual images as rhetorical elements. These discourses covered a variety of heterogeneous fields, from medical to legal, social and political, as well as to the critical reformer and the religious counter-reformer. This paper analyzes how these images and their speech were configured in the Modern Age in connection with the dialectic among the way in which madness acquired iconographic category and its real life. The paper analyzes this process through the ridicule clothes, which the mad was forced to wear when he was admitted to certain hospitals, and dress maskes, as the jester or the baffoon. This work proposes an exploration into the mechanisms that converted the visual and textual representation of folly in a topos with moralizing dimension, and extremely

  6. Nouveau déphaseur variable analogique large-bande

    OpenAIRE

    Khoder , Khaled; Le Roy , Marc; Pérennec , André

    2013-01-01

    National audience; Dans cet article, une nouvelle topologie de déphaseur analogique variable est proposée. Elle est obtenue en inter-combinant un déphaseur de Schiffman et un déphaseur passe-tout mixte distribué/localisé. Ce déphaseur compact présente l'avantage d'une forte agilité en phase pour une variation limitée de la capacité de la varicap. Les mesures du dispositif réalisé en technologie hybride microruban confirme une variation continue du déphasage jusqu'à 180° pour un circuit à une ...

  7. Note sur un Lepidocyclina nouveau de Bornéo

    NARCIS (Netherlands)

    Schlumberger, C.

    1899-01-01

    Les travaux des géologues hollandais et de quelques savants anglais nous ont déjà fait connaître un bon nombre de foraminifères fossiles de Java et de Borneo, mais il reste encore à glaner après eux. Je viens de trouver dans une roche calcaire de Borneo que Mons. MARTIN, professeur à Leiden, a bien

  8. Un nouveau rapport indique que les entrepreneurs vietnamiens sont ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    17 juil. 2015 ... New report shows Vietnamese entrepreneurs are growth-oriented. ​More than 70 of Vietnamese entrepreneurs choose to start a business to take advantage of opportunities. View moreNew report shows Vietnamese entrepreneurs are growth-oriented ...

  9. Helicopsyche margaritensis, Trichoptère nouveau des Petites Antilles

    NARCIS (Netherlands)

    Botoşaneanu, L.

    1959-01-01

    J’ai récemment reçu du Dr. P. WAGENAAR HUMMELINCK de Utrecht environ 230 exemplaires (larves, nymphes et fourreaux vides) d’un Helicopsyche, recueillis par lui-même en 1936 en quelques localités de l’île de Margarita (Venezuela). Grâce au fait que les armatures génitales du ♂ et de la ♀ purent être

  10. Le nouveau modèle africain | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    22 juil. 2011 ... L'annulation de la dette, un commerce plus équitable, davantage d'aide : voilà le plan d'action mondial dont on convient qu'il faut de toute urgence mettre en oeuvre en vue d'accélérer le développement en Afrique. Or, ce serait rater le bateau que de ne pas s'engager dans la voie tout autre que les ...

  11. Jean Gadrey, Nouvelle économie, nouveau mythe ?

    Directory of Open Access Journals (Sweden)

    Diane-Gabrielle Tremblay

    2002-10-01

    Full Text Available La « nouvelle économie » est partout dans les médias nord-américains, comme européens. L’ouvrage de Jean Gadrey est rafraîchissant, car il présente une critique et une analyse minutieuse du concept, de son apparition, des développements qui y sont associés, des thèses et idées défendues au nom de la « nouvelle économie ».Comme il le note bien « les mythes mobilisateurs fleurissent, mais la réflexion sur les contours de cet âge et sur les risques sociaux à prévenir est inexistante : les formul...

  12. Nouveau webinaire IWRA/CRDI sur les changements climatiques et ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    18 avr. 2018 ... Contrats d'options d'eau pour l'adaptation aux changements climatiques à Santiago (Chili);. • Adaptation aux changements climatiques dans les bassins hydrographiques en voie d'urbanisation rapide: enseignements issues d'une approche tenant compte des préoccupations et des facteurs de stress ...

  13. Un nouveau tableau de Zurbarán en Normandie

    Directory of Open Access Journals (Sweden)

    Pierre Curie

    2005-09-01

    Full Text Available Actuellement en cours de restauration, cette Apparition de l’Enfant Jésus à saint Antoine de Padoue de Francisco de Zurbarán (1598-1664, récemment découverte dans l’église d’Etreham (Calvados, est intéressante par son thème, rare dans l’œuvre du maître, et par sa qualité plastique. Sa provenance, encore hypothétique, pourrait être un don du comte de Houdetot (1778-1859, artiste, personnalité politique et collectionneur qui posséda plusieurs peintures espagnoles.The painting of the Apparition de l’Enfant Jésus à Saint Antoine de Padoue by Francisco de Zurbarán (1598-1664, recently discovered in the church of Etreham (Calvados is presently undergoing restoration. The painting is interesting in terms of its theme, one rarely dealt with by this master, and in terms of its plastic qualities. The provenance of the painting is uncertain, but it could be a gift of the Comte de Houdetot (1778-1859, artist, political figure and art collector who possessed several Spanish paintings.

  14. Upheavals of Emotions, Madness of Form: Mary M. Talbot’s and Bryan Talbot’s Dotter of Her Father’s Eyes and a Transdiegetised (AutoBiographical Commix

    Directory of Open Access Journals (Sweden)

    Kusek Robert

    2015-07-01

    Full Text Available In 2012, Mary M. Talbot and Bryan Talbot joined the likes of Richard Ellmann, Gordon Bowker and Michael Hastings and in their graphic memoir Dotter of Her Father’s Eyes (2012 offered a new re-telling of James Joyce’s life, focusing, in particular, on the difficult relationship between the great Irish writer, and his daughter Lucia. However, the story of a complicated emotional bond between Joyce and Lucia was only a framework for an autobiographical coming-of age narrative about Mary M. Talbot herself and her violent relationship with James S. Atherton, a celebrated Joycean scholar and her very own “cold mad feary father”. Following Martha C. Nussbaum’s conception about cognitive and narrative structure of emotions postulated in Love’s Knowledge (1990 and Upheavals of Thoughts (2001, this article wishes to argue in favour of an organic connection between the volume’s thematic concerns and its generic affiliation. In other words, it discusses how a specific class of emotions pertaining to Lucia’s gradual mental disintegration can be adequately told only in a specific literary form, i.e. in a transdiegetised “commix”, an (autobiographical account which occupies a threshold space between a comic and a novel, fiction and non-fiction, biography and autobiography, words and pictures.

  15. La imagen del ‘sueño americano’: estética y modelos de belleza de la sociedad americana a través de ‘Mad Men'

    Directory of Open Access Journals (Sweden)

    Francisco Cabezuelo Lorenzo

    2012-04-01

    Full Text Available El presente artículo pretende desgranar la fórmula con la que una serie actual puede desarrollar herramientas para reproducir los modelos de belleza típicamente americanos de los años cincuenta y sesenta, un período histórico que supone para Occidente el nacimiento de la actual sociedad de consumo. Este trabajo analiza la primera temporada de la serie de televisión ‘Mad Men’ ambientada en Nueva York y que cuenta la vida de la agencia de publicidad ficticia ‘Sterling Cooper’ situada en Madison Avenue. A través de sugerentes pinceladas fílmicas, la serie es un retrato de la sociedad y cultura de los primeros años sesenta, haciendo hincapié en problemas sociales, éticos y estéticos como las conductas sexuales, el alcohol, el tabaco, el adulterio, la homofobia, el antisemitismo, o el racismo, de modo que muestra crueles ejemplos de la sociedad del momento. Pero, al mismo tiempo mira con nostalgia al pasado. A su vez, se hace eco de los problemas sociales del momento. Por estos motivos, puede ser considerada una serie que refleja y reproduce la estética de aquellos años que marcaron el nacimiento del ‘sueño americano’ tan ligado a la Publicidad y la Comunicación de Masas.

  16. Simulation numerique de l'accretion de glace sur une pale d'eolienne

    Science.gov (United States)

    Fernando, Villalpando

    The wind energy industry is growing steadily, and an excellent place for the construction of wind farms is northern Quebec. This region has huge wind energy production potential, as the cold temperatures increase air density and with it the available wind energy. However, some issues associated with arctic climates cause production losses on wind farms. Icing conditions occur frequently, as high air humidity and freezing temperatures cause ice to build up on the blades, resulting in wind turbines operating suboptimally. One of the negative consequences of ice accretion is degradation of the blade's aerodynamics, in the form of a decrease in lift and an increase in drag. Also, the ice grows unevenly, which unbalances the blades and induces vibration. This reduces the expected life of some of the turbine components. If the ice accretion continues, the ice can reach a mass that endangers the wind turbine structure, and operation must be suspended in order to prevent mechanical failure. To evaluate the impact of ice on the profits of wind farms, it is important to understand how ice builds up and how much it can affect blade aerodynamics. In response, researchers in the wind energy field have attempted to simulate ice accretion on airfoils in refrigerated wind tunnels. Unfortunately, this is an expensive endeavor, and researchers' budgets are limited. However, ice accretion can be simulated more cost-effectively and with fewer limitations on airfoil size and air speed using numerical methods. Numerical simulation is an approach that can help researchers acquire knowledge in the field of wind energy more quickly. For years, the aviation industry has invested time and money developing computer codes to simulate ice accretion on aircraft wings. Nearly all these codes are restricted to use by aircraft developers, and so they are not accessible to researchers in the wind engineering field. Moreover, these codes have been developed to meet aeronautical industry specifications, which are different from those that must be met in the wind energy industry. Among these differences are the following: wind turbines operate at subsonic speeds; the cords and angles of attack of wind turbine blades are smaller than those of aircraft wings; and a wind turbine can operate with a larger ice mass on its blades than an aircraft can. So, it is important to provide wind energy researchers with tools specifically validated with the operations parameters of a wind turbine. The main goal of this work is to develop a methodology to simulate ice accretion in 2D using Fluent and Matlab, commercial software programs that are available at nearly all research institutions. In this study, we used Gambit, previously the companion tool of Fluent, for mesh generation, and which has now been replaced by ICEM. We decided to stay with Gambit, because we were already deeply involved with the meshing procedure for our simulation of ice accretion at the time Gambit was removed from the market. We validate the methodology with experimental data consisting of iced airfoil contours obtained in a refrigerated wind tunnel using the parameters of actual ice conditions recorded in northern Quebec. This methodology consists of four steps: airfoil meshing, droplet trajectory calculation, thermodynamic model application, and airfoil contour updating. The total simulation time is divided into several time steps, for each of which the four steps are performed until the total time has elapsed. The time step length depends on the icing conditions. (Abstract shortened by UMI.).

  17. The department Charter of the Finistere wind turbines; La charte departementale des eoliennes du Finistere

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-06-01

    In a context favorable to the renewable energies development, the Finistere showed in few months many wind turbines installation projects. Those projects present conflicting stakes: the richest areas in terms of energy are also the most sensitive in term of ecology and environment. The conciliation of these conflicting stakes is difficult because the town planning documents do not take into account these installations specificities. Therefore the Finistere decided to write a department charter for the wind turbines. The first chapter deals with the objectives and the partners engagements, the second chapter presents elements of decision making. (A.L.B.)

  18. A new generation of wind turbines; Une nouvelle generation d'eoliennes

    Energy Technology Data Exchange (ETDEWEB)

    Nica, H. [Tesnic, Laval, PQ (Canada)

    2008-06-15

    Although homeowners have expressed a desire to use wind energy to supply their electricity needs, many technical barriers have stood in the way of installing wind turbines in urban settings. This was due in part to three-bladed vertical axis turbines, high technical costs, limited performances in urban settings and questionable aesthetics. Tesnic has considered these issues and proposed a completely different turbine that uses a different method for extracting energy from the wind. The first approved 3.6 kW model should appear by the end of 2009. This new turbine is based on the same principal of the steam turbine patented in 1913 by Nikola Tesla. Instead of having blades, the Tesla turbine used closely spaced parallel disks and was recognized as being very robust with a high efficiency rating. Tesnic's new wind powered turbine is a vertical axis turbine with a series of valves that directs the wind on a rotor assembly of disk space. A series of blades on its circumference redirects the wind through the assembly of discs and accelerates the rotation of the rotor. The turbine extracts the wind energy in several ways, including conventional drag and lift, adherence and the vortex effect. This gives a 50 per cent added value of efficiency compared to other wind powered turbines. The global market for small wind powered energy is in full expansion. It has been projected that small turbines with 1 kW capacity will be abundant by 2020. It was noted that for household wind powered energy, the market must consider issues of cost, low maintenance, noise pollution, visual aesthetics, durability and safety. Wind energy can also be used in several industries, including plastics, composites, light metals, textiles and electronics. 2 figs.

  19. Proposal of a new architecture for the electricity market. Report for France Energie Eolienne

    International Nuclear Information System (INIS)

    2014-09-01

    In a context of evolution of electricity markets in all European countries, with notably an increasing share of renewable energies (particularly wind and solar energy), and as there are two main objectives for the future electricity market rules (integration of renewable energies within the market, market adaptation to a strong development of these energies), this document reports the development of recommendations for the implementation of a market architecture which would promote these objectives in France. These recommendations concern the access to the grid, the wholesale market, adjustment rules, an additional remuneration for renewable energies, the retail market, and the carbon market

  20. The wind power has a fair wind; L'energie eolienne dans le vent

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    After a presentation of the state of the art concerning the world energy consumption, regulation and the renewable energies situation in the french market, this document details the wind power: this energy origin, the operating and the implementation, the wind energy cost, the environmental effects and impacts, the compatibility with the agriculture, the wind power industry and market and the long-dated evolution perspectives. (A.L.B.)

  1. Report on the safety of wind turbines installations; Rapport sur la securite des installations eoliennes

    Energy Technology Data Exchange (ETDEWEB)

    Guillet, R.; Leteurtrois, J.P.

    2004-07-01

    This report aims to study the regulatory framework governing the safety of wind turbines and proposes improvement actions. It concerns the wind turbines risk assessment, the technical bases of the wind turbines safety, the regulation relative to the safety and possible evolutions. (A.L.B.)

  2. Basics on wind energy; Introduction a l'energie eolienne

    Energy Technology Data Exchange (ETDEWEB)

    Paluch, B. [ONERA, Dept. Mecanique des Structures et de L' endommagement (DMSE), 59 - Lille (France)

    2005-05-01

    Among all the renewable energies, wind energy knows the strongest progression. The EEC, and more particularly Germany, are at the world top position. Many countries now consider offshore as an alternative to land sites saturation. The three-bladed horizontal axis wind turbines largely dominate the market. The tendency lies now in the multi-megawatts wind turbines exceeding 80 m in diameter. Wind energy takes benefits from mature technologies, since there are less and less expensive and easily exploitable. However many technological challenges still remain to raise. In some countries, the obligation to buy the electricity produced by wind energy at attractive rates allowed the growth of a wind industrial sector, exporting technologies and generating employment. Within the framework of sustainable development, the resource durability has direct repercussions on the local economies. (author)

  3. Promotion of terrestrial wind power; Promotion de l'energie eolienne terrestre

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-09-01

    This document, from the French ministries of ecology and sustainable development, of equipment, transports, dwelling, tourism and sea, and of industry, is addressed to the region and departement prefects. It recalls the main trends of the French energy and environmental policy and the role the prefects have to play for the enforcement of this policy. The present document concerns the promotion of terrestrial wind power. The recommendations are the following: 1 - warranting the clarity and transparency of the procedures leading to the building of wind farms and to their connection to the national power grid; 2 - to make easy the local setting up of wind power equipments in the respect of environmental requirements, starting from a good knowledge of the stakes and implemented in a pre-concerned way. Three documents are attached in appendixes: some additional information about the procedures linked with a wind power project, a synthetic table of these procedures, and a synthetic table of the new dispositions of the law no 2003-590 from July 2, 2003 about town planning and accommodation. (J.S.)

  4. Development of wind energy in Morocco; Developpement de l'energie eolienne au Maroc

    Energy Technology Data Exchange (ETDEWEB)

    Enzili, M. [Centre de Developpement des Energies Renouvelables de Maroc, Rabat (Morocco)

    2008-04-15

    Morocco's national energy policy includes the use of renewable energy sources to lessen its reliance on fossil fuels such as coal and oil. Legislation was recently passed to increase the threshold of electrical power from 10 MW to 50 MW. Solar and wind energy are the most abundant renewable energy resources in the country and are recommended for exploitation on a large scale. Feasibility studies conducted by the Centre de Developpement des Energies Renouvelables have shown that Morocco has enough wind energy to produce electricity on a large scale and interconnect it with the national power grid. Wind energy in the country could also be used for on-site power generation in remote villages or for desalination of seawater, particularly in the southern regions of Morocco which are most affected by drought. Essaouira, Tangier, Tetouan, Tarfaya, Dakhla, Laayoune and Taza were among the regions identified with significant wind resources. The total wind energy potential for Morocco is estimated to be 2,650 GW, while the technical wind energy potential is estimated to be 1,600 GW. Several projects have been realized in the areas of electricity production, interconnection to the national power grid, decentralized rural electrification and eventually the introduction of water pumping. It was concluded that exporting green energy to Europe, via the Morocco-Spain route after the restructuring of Morocco's electricity sector will create a viable market for the medium and long-term. 3 figs.

  5. Wind turbines in Switzerland - Bat mortality; Eoliennes en Suisse - Mortalite de chauves-souris

    Energy Technology Data Exchange (ETDEWEB)

    Leuzinger, Y.; Lugon, A.; Bontadina, F.

    2008-03-15

    There are growing concerns about possible negative impact of wind turbines on bats. In this study we evaluated the occurrence of bat mortality caused by wind turbines in Switzerland. From about 20 existing wind turbines in year 2007 we selected five medium to large sized turbines in two hilly regions of Switzerland. Between June and October we searched 10 times in regular intervals for carcasses on the ground (total 50 controls) in a circle of up to 40 m distance to the tower. We measured detectability and bait removal rates by experiments at every site (using 12 dummy bats and 10 dead mice per site, respectively). Two bat carcasses were found at two sites, one of the migrating species N. leisleri in August, another in September, belonging to the non-migrating species P. pipistrellus. The detectability was 74 {+-} 13% (mean {+-} standard deviation). The removal rate was 72 {+-} 25% in the first 2-3 days and an average of 91% in the control intervals of 15 days. Estimates of seasonal bat mortality, corrected for season, detectability and removal rate, revealed an average of 8.2 (range 4.9 - 11.4) dead bats per turbine and season. This study demonstrates the occurrence of bat mortality caused by wind turbines in Switzerland. However, the estimated mortality per season remains in international comparisons small to medium at the studied sites. The mortality of individuals of endangered and protected species is a serious issue, but most important, the long-term effect on populations is difficult to assess. In the case of the investigated wind turbines the negative impact on bats does not generally preclude the development of wind energy sites in Switzerland. We recommend avoiding sites in and near woodlands. The abundance of local and migratory bats at planned sites should be evaluated, obligatory in the case of larger wind parks and at exposed sites (ridge tops, mountain passes, river valleys), in order to consider adequately bat conservation. (author)

  6. OPTIMIZATION OF AEOLIAN ENERGY CONVERSION OPTIMISATION DE LA CONVERSION DE L’ENERGIE EOLIENNE

    Directory of Open Access Journals (Sweden)

    Y. Soufi

    2015-08-01

    Full Text Available The use of renewable energy increases, because people are increasingly concerned with environmental issues. Among renewable, wind power is now widely used. Their study showed that a value of wind speed, there is a maximum mechanical power supplied by the turbine. So, power is supplied are particularly changes with maximum speed.However, the objective of this paper is to present an algorithm for optimal conversion of wind energy based on a criterion optimization that must maintain specific speed of the turbine at optimum speed which corresponds to the maximum power provided by the steady wind turbine. To this end, the object is to preserve the position of any static operating point on the characteristic of optimal.To validate the model and algorithm for optimal conversion of wind energy, a series of numerical simulations carried out using the software MatLab Simulink will be presented is discussed.

  7. Wind energy in Africa; L'energie eolienne en Afrique

    Energy Technology Data Exchange (ETDEWEB)

    Kone, A. [Moncton Univ., NB (Canada)

    2008-04-15

    This article discussed the opportunities that wind energy technology can bring to developing countries in Africa. Solar, hydro and wind energy along with biofuels are among the renewable energy sources being used in Africa, although wind energy is not being used to its potential due to a lack of financial means; constraints in regulatory legislation; lack of structure; lack of knowledge concerning wind energy; and the lack of competent human resources for the installation and management of wind turbines. Technical barriers also exist, such as the lack of interconnection networks and the already existing facilities for power generation. According to a 2004 Canadian study, the greatest potential for wind energy development lies in the northern part of Africa followed by regions in the east, west and south of the continent. Morocco and Tunisia have established regulations regarding wind energy development. Countries such as Algeria and Egypt, which have abundant fossil fuel, would turn to wind energy from an environmental standpoint. The countries of Djibouti, Lesotho, Tchad, Seychelles, Mauritius rely on other forms of renewable energy, including hydro, geothermal, photovoltaic and biofuels. It was concluded that the future of wind energy relies on regional cooperation, technology transfer and subsidies from industrialized nations. 1 fig.

  8. Estranhos interiores: a loucura em triste fim de Policarpo Quaresma Los extraños interiores: la locura en triste fin de Policarpo Quaresma Strange inside: madness in Lima Barreto's triste fim de Policarpo Quaresma

    Directory of Open Access Journals (Sweden)

    Marco Antonio Arantes

    2008-12-01

    suburban, courageous, ironic and combative writer, but also a Black man who was ostracized and misunderstood by many of his contemporaries. He experienced the critics' contempt and his family's indifference towards his vocation as a literary man. Restless in pain and harsh with hypocrites, he had to face madness, alcoholism and racial bias. The article reports the relationships between the madness of his father, João Henriques, and Major Quaresma, the protagonist of Lima Barreto's novel Triste Fim de Policarpo Quaresma. The novel is a mélange involving fantasy and reality, literature and confession. It involves a domestic fact mentioned by his biographer: his father's mental alienation and the family's tragic condition brought about by long and endless neurasthenic crises. Themes are foregrounded by the aesthetics of existence through which life is analyzed as a work of art.

  9. Isolation of the three grape sub-lineages of B-class MADS-box TM6, PISTILLATA and APETALA3 genes which are differentially expressed during flower and fruit development.

    Science.gov (United States)

    Poupin, María Josefina; Federici, Fernán; Medina, Consuelo; Matus, José Tomás; Timmermann, Tania; Arce-Johnson, Patricio

    2007-12-01

    The B class of MADS-box floral homeotic genes specifies petal and stamen identity in angiosperms. While this group is one of the most studied in herbaceous plant species, it has remained largely uncharacterized in woody species such as grapevine. Although the B class PI/GLO and AP3/DEF clades have been extensively characterized in model species, the role of the TM6 subgroup within the AP3 clade is not completely understood, since it is absent in Arabidopsis thaliana. In this study, the coding regions of VvTM6 and VvAP3 and the genomic sequence of VvPI, were cloned. VvPI and AtPI were confirmed to be functional homologues by means of complementation of the pi Arabidopsis mutant. Expression analysis revealed that VvPI and VvAP3 transcripts are restricted almost exclusively to inflorescences, although VvPI was detected at low levels in leaves and roots. VvTM6 expresses throughout the plant, with higher levels in flowers and berries. A detailed chronological study of grape flower progression by light microscopy and temporal expression analysis throughout early and late developmental stages, revealed that VvPI expression increases during pollen maturation and decreases between the events of pollination and fertilization, before the cap fall. On the other hand, VvTM6 is expressed in the last stage of anther development. Specific expression of VvAP3 and VvPI was detected in petals and stamens within the flower, while VvTM6 was also expressed in carpels. Moreover, this work provides the first evidence for expression of a TM6-like gene throughout fruit growth and ripening. Even if these genes belong to the same genetic class they could act in different periods and/or tissues during reproductive organ development.

  10. Non-destructive in situ study of “Mad Meg” by Pieter Bruegel the Elder using mobile X-ray fluorescence, X-ray diffraction and Raman spectrometers

    Energy Technology Data Exchange (ETDEWEB)

    Van de Voorde, Lien, E-mail: lien.vandevoorde@ugent.be [Ghent University, Department of Analytical Chemistry, X-ray Microspectroscopy and Imaging Research Group, Krijgslaan 281 S12, B-9000 Gent (Belgium); Van Pevenage, Jolien [Ghent University, Department of Analytical Chemistry, Raman Spectroscopy Research Group, Krijgslaan 281 S12, B-9000 Gent (Belgium); De Langhe, Kaat [Ghent University, Department of Archaeology, Archaeometry Research Group, Sint-Pietersnieuwstraat 35, B-9000 Gent (Belgium); De Wolf, Robin; Vekemans, Bart; Vincze, Laszlo [Ghent University, Department of Analytical Chemistry, X-ray Microspectroscopy and Imaging Research Group, Krijgslaan 281 S12, B-9000 Gent (Belgium); Vandenabeele, Peter [Ghent University, Department of Archaeology, Archaeometry Research Group, Sint-Pietersnieuwstraat 35, B-9000 Gent (Belgium); Martens, Maximiliaan P.J. [Ghent University, Department of Art, Music and Theatre Sciences, Blandijnberg 2, B-9000 Gent (Belgium)

    2014-07-01

    Mad Meg”, a figure of Flemish folklore, is the subject of a famous oil-on-panel painting by the Flemish renaissance artist Pieter Bruegel the Elder, exhibited in the Museum Mayer van den Bergh (Antwerp, Belgium). This article reports on the in situ chemical characterization of this masterpiece by using currently available state-of-the-art portable analytical instruments. The applied non-destructive analytical approach involved the use of a) handheld X-ray fluorescence instrumentation for retrieving elemental information and b) portable X-ray fluorescence/X-ray diffraction instrumentation and laser-based Raman spectrometers for obtaining structural/molecular information. Next to material characterization of the used pigments and of the different preparation layers of the painting, also the verification of two important historical iconographic hypotheses is performed concerning the economic way of painting by Brueghel, and whether or not he used blue smalt pigment for painting the boat that appears towards the top of the painting. The pigments identified are smalt pigment (65% SiO{sub 2} + 15% K{sub 2}O + 10% CoO + 5% Al{sub 2}O{sub 3}) for the blue color present in all blue areas of the painting, probably copper resinate for the green colors, vermillion (HgS) as red pigment and lead white is used to form different colors. The comparison of blue pigments used on different areas of the painting gives no differences in the elemental fingerprint which confirms the existing hypothesis concerning the economic painting method by Bruegel. - Highlights: • In situ, non-destructive investigation of a famous painting by Pieter Bruegel. • Use of a new, commercial available, portable XRF/XRD instrumentation. • Multi-methodological approach: make also use of a mobile Raman spectrometer. • Used pigments and different preparation layers of the painting are characterized. • The verification of two important historical iconographic hypotheses are performed.

  11. Non-destructive in situ study of “Mad Meg” by Pieter Bruegel the Elder using mobile X-ray fluorescence, X-ray diffraction and Raman spectrometers

    International Nuclear Information System (INIS)

    Van de Voorde, Lien; Van Pevenage, Jolien; De Langhe, Kaat; De Wolf, Robin; Vekemans, Bart; Vincze, Laszlo; Vandenabeele, Peter; Martens, Maximiliaan P.J.

    2014-01-01

    Mad Meg”, a figure of Flemish folklore, is the subject of a famous oil-on-panel painting by the Flemish renaissance artist Pieter Bruegel the Elder, exhibited in the Museum Mayer van den Bergh (Antwerp, Belgium). This article reports on the in situ chemical characterization of this masterpiece by using currently available state-of-the-art portable analytical instruments. The applied non-destructive analytical approach involved the use of a) handheld X-ray fluorescence instrumentation for retrieving elemental information and b) portable X-ray fluorescence/X-ray diffraction instrumentation and laser-based Raman spectrometers for obtaining structural/molecular information. Next to material characterization of the used pigments and of the different preparation layers of the painting, also the verification of two important historical iconographic hypotheses is performed concerning the economic way of painting by Brueghel, and whether or not he used blue smalt pigment for painting the boat that appears towards the top of the painting. The pigments identified are smalt pigment (65% SiO 2 + 15% K 2 O + 10% CoO + 5% Al 2 O 3 ) for the blue color present in all blue areas of the painting, probably copper resinate for the green colors, vermillion (HgS) as red pigment and lead white is used to form different colors. The comparison of blue pigments used on different areas of the painting gives no differences in the elemental fingerprint which confirms the existing hypothesis concerning the economic painting method by Bruegel. - Highlights: • In situ, non-destructive investigation of a famous painting by Pieter Bruegel. • Use of a new, commercial available, portable XRF/XRD instrumentation. • Multi-methodological approach: make also use of a mobile Raman spectrometer. • Used pigments and different preparation layers of the painting are characterized. • The verification of two important historical iconographic hypotheses are performed

  12. A New Apparatus for Inelastic, Quasi-Elastic and Elastic Cold Neutron Measurements; Un nouveau appareil pour les mesures de diffusion inelastique , quasi-elastique et elastique des neutrons lents; Novyj pribor dlya izmereniya neuprugogo, kvaziuprugogo i uprugogo rasseyaniya kholodnykh nejtrohov; Nuevo aparato para mediciones inelastic as, cuasi elasticas y elasticas de neutrones frios

    Energy Technology Data Exchange (ETDEWEB)

    Otnes, K; Palevsky, H [Brookhaven National Laboratory, Upton, NY (United States)

    1963-01-15

    A new chopper apparatus for use at the Brookhaven High Flux Beam Reactor is now under construction. It is a three-element phased rotof system. The rotors are 80 cm in diameter, run at a maximum speed of 15000 rev/min, and are designed to give three neutron bursts of monochromatic neutrons per revolution. Two rotors spin about a horizontal axis whereas the third operates vertically. The system can be operated with either one, two or three of the chopper elements, depending on the type of measurement that is completed. For inelastic measurements where the neutron gains energy, a double rotor system will be most useful. For this configuration the burst time and wave length spread (full widths at 1/2 maximum) will be 16 {mu}s and 0.16 A for 4 A incident neutrons, and the intensity at the sample (4 x 1.6 cm) will be 2 x 10{sup 6} n/s. For quasi-elastic and elastic neutron measurements the three-rotor configuration will be best suited. The corresponding burst time and wave length spread can be as small as 8 {mu}s and 0.04 A giving an intensity of 10{sup 4} n/s on a sample of (4 X 0.8 c m ), The wave length and time resolution are adjustable between the above two limits in such a way as to obtain the maximum neutron intensity for a given experiment. (author) [French] Un nouveau selecteur destine au reacteur a haut flux de Brookhaven est actuellement en construction. Il s'agit d'un dispositif a trois rotors dephasables. Les rotors ont un diametre de 80 cm, tournent a une vitesse maximum de 15 000 tours pat minute et sont concus de maniere a fournir trois bouffees de neutrons monochromatiques a chaque tour. Deux rotors tournent autour d'un axe horizontal, le troisieme, autour d'un axe vertical. Le dispositif peut fonctionner avec un, deux ou trois elements, selon le type de mesure que l'on se propose de faire. Pour les mesures de diffusion inelastique ou les neutrons gagnent de l'energie, un dispositif a deux rotors sera tres utile. Pour cette configuation, la duree et la

  13. Algunas elaboraciones psicoanalíticas en torno del uso del concepto de locura como distinto del concepto de psicosis Some psychoanalytic elaborations about the use of the madness concept like different from the psychosis concept

    Directory of Open Access Journals (Sweden)

    Pablo D. Muñoz

    2009-12-01

    Full Text Available La distinción conceptual locura-psicosis no ha sido objeto de elaboración sistemática en el campo del psicoanálisis. Hasta Jacques Lacan, quien la ha examinado con diversos recursos conceptuales, los psicoanalistas los han tomado habitualmente como equivalentes. Sin embargo, algunos pocos autores han avanzado en ese sentido. En este artículo se propone el análisis de algunos de ellos con un objetivo doble: primero, reconocer esos antecedentes psicoanalíticos para constatar su coincidencia o no con las elaboraciones de Lacan y, en consecuencia, poder ponderar con mayor justeza la novedad conceptual introducida por él; y, segundo, y fundamentalmente, dar respuesta al problema clínico introducido muy tempranamente por Freud, cuando afirma que hay psicosis de defensa que pueden interrumpir episódicamente la trayectoria de una neurosis. Problema al que los teóricos del psicoanálisis han respondido con conceptos como el de caso borderline o estados límites que desde la perspectiva de la teoría lacaniana no resultan suficientes.The conceptual distinction madness-psychosis has not been object of systematic elaboration in psychoanalysis field. Until Jacques Lacan, who has examined it with diverse conceptual resources, the psychoanalysts have been taken them as synonyms. However, some few authors have advanced in the way of a distinction. This article aims analyze some of them with a double goal: first one, to identify and refine this psychoanalytic background to verify coincidence or not with the Lacan working and, consequently, be able to appreciate with greater precision the conceptual originality introduced by him; and, secondly, and essentially, answer the clinical problem introduced by the "early" Freud, when affirms that can be found defense psychoses whose can episodically interrupt a neurosis trajectory. Problem that try to be solved by some psychoanalysis theoreticians with concepts as "case borderline" or states limits, that from

  14. A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3.

    Directory of Open Access Journals (Sweden)

    Géraldine Arrode-Brusés

    2016-06-01

    Full Text Available Mucosal HIV-1 transmission is inefficient. However, certain viral and host characteristics may play a role in facilitating HIV acquisition and systemic expansion. Cells expressing high levels of integrin α4β7 have been implicated in favoring the transmission process and the infusion of an anti-α4β7 mAb (RM-Act-1 prior to, and during a repeated low-dose vaginal challenge (RLDC regimen with SIVmac251 reduced SIV acquisition and protected the gut-associated lymphoid tissues (GALT in the macaques that acquired SIV. α4β7 expression is required for lymphocyte trafficking to the gut lamina propria and gut inductive sites. Several therapeutic strategies that target α4β7 have been shown to be effective in treating inflammatory conditions of the intestine, such as inflammatory bowel disease (IBD. To determine if blocking α4β7 with ELN, an orally available anti-α4 small molecule, would inhibit SHIV-SF162P3 acquisition, we tested its ability to block MAdCAM-1 (α4β7 natural ligand and HIV-gp120 binding in vitro. We studied the pharmacokinetic profile of ELN after oral and vaginal delivery in macaques. Twenty-six macaques were divided into 3 groups: 9 animals were treated with ELN orally, 9 orally and vaginally and 8 were used as controls. All animals were challenged intra-vaginally with SHIV-SF162P3 using the RLDC regimen. We found that ELN did not protect macaques from SHIV acquisition although it reduced the SHIV-induced inflammatory status during the acute phase of infection. Notably, integrins can exist in different activation states and, comparing the effect of ELN and the anti-α4β7 mAb RM-Act-1 that reduced susceptibility to SIV infection, we determined that ELN induces the active conformation of α4β7, while RM-Act-1 inhibits its activation through an allosteric mechanism. These results suggest that inhibition of α4β7 activation may be necessary to reduce susceptibility to SIV/SHIV infection and highlight the complexity of anti

  15. Näitlejaego vs lavastajaterror / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2009-01-01

    1.-18. maini Berliinis toimunud teatrifestivalist "Theatertreffen". Pikemalt J. Meyerhoffi monolavastusest "Alle Toten fliegen hoch" ("Kõik surnud lendavad kõrgel(t)"). Jürgen Goschi töödest - "Hier und jetzt" ("Siin ja praegu", aut. Roland Schimmelpfennig) ja "Kajakas" (A. Tšehhov). Frank Kafka "Protsess" Andreas Kriegenburgi lavastuses. Friedrich Schilleri "Röövlid" Nicholas Stemanni lavastuses. Peter Weissi "Marat, was ist aus unserer Revolution geworden?" ("Marat, mis on küll meie revolutsioonist saanud?) Volker Löschi lavastuses

  16. Appraising the Risks of Reefer Madness

    OpenAIRE

    Murray, Robin

    2015-01-01

    Editor?s Note: Studies that have tied cannabis use to schizophrenia in the developing brain are just the tip of the iceberg when it comes to marijuana. Are different strains and synthetic cannabinoids especially dangerous? Are we doing enough to educate young people on the risks? Does marijuana use lower IQ? Where is the line between medical marijuana and recreational use? Our author, a noted British psychiatrist, offers a European perspective on these issues.

  17. Kes kardab saksa teatrit? / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2007-01-01

    5.-20. maini Berliinis toimunud festivalist "Theatertreffen". Lavastustest: Yasmina Reza "Barbaarsuse jumal" ("Der Gott des Gemetzels"), lavastaja Jürgen Gosch, Schauspielhaus Zürich. Goethe "Noore Wertheri kannatused", lavastaja Jan Bosse, Berliini Gorki teater. Aischylose "Oresteia", lavastaja Michael Thalheimer, kunstnik Olaf Altmann. Moliere'i "Tartuffe", lavastaja Dimiter Gotscheff, Hamburgi Thalia teater

  18. Uljas ja uudishimulik 20-aastane / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2007-01-01

    VAT Teatri lavastustest - Amélie Nothombi romaani järgi "Vaenlase kosmeetika" (lav. Peeter Raudsepp), Kristof Magnussoni "Meeste varjupaik" (lav. Christian Römer), Hans Christian Anderseni järgi "Merineitsi" (lav. Aare Toikka) ja Urmas Vadi "Elvis oli kapis" (lav. Aare Toikka)

  19. The Madness of Weighted Mean Faculty Salaries

    Science.gov (United States)

    Micceri, Theodore

    2009-01-01

    Higher education frequently uses weighted mean faculty salaries to compare either across institutions, or to evaluate an institution's salary growth over time. Unfortunately, faculty salaries are an extraordinarily complex phenomenon that cannot be legitimately reduced to a single number any more than the academic construct of skills, knowledge,…

  20. Being Mad in Early Modern England

    Directory of Open Access Journals (Sweden)

    Aleksandar eDimitrijevic

    2015-11-01

    Full Text Available It has become almost a rule that the birth of scientific psychiatry and what we today term clinical psychology took place in the short period between the last decade of the XVIII century and the 1820s. Everything that happened before that period – every description, diagnosis, and therapy – has been considered ‘pre-scientific,’ outdated, in a way worthless.In this paper, however, I am providing the argument that, first, the roots of contemporary psychiatry reach at least to England of the early modern period, and that, second, it may still turn out that in the field of mental health care historical continuities are more numerous and persistent than discontinuities. Thus, I briefly review the most important surviving documents about the treatment of mental disorders in England of Elizabethan and Jacobian period, organizing the argument around the well-known markers: diagnostics and aetiology, therapy, organization of the asylum, the public image of the mentally ill…

  1. George Tabori - maailma vanim lavastaja / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2006-01-01

    24. mail tähistati Berliinis lavastaja ja näitekirjaniku 92. sünnipäeva. Tema elust, näidenditest, lavastustest. Lähemalt Berliner Ensemble'i mängukavas olevatest tema oma näidendist "Juubel" ja Samuel Beckett'i lavastusest "Godot'd oodates". (Ajalehe rubriigipealdis "SIRP eri : Festivaliteater")

  2. Managers can drive their subordinates mad.

    Science.gov (United States)

    Kets de Vries, M F

    1979-01-01

    This article explores the phenomenon of "folie à deux"--an aberrant relationship between manager and subordinates that is characterized by shared delusions. Though most visible among public figures like Adolf Hitler, J. Edgar Hoover and Jim Jones, the problem also surfaces among private managers and their associates with dangerous implications for the firm. In folie à deux, the unusual behavior patterns of a manager in an isolated setting become mirrored by dependent subordinates, and the organization loses touch with its original goals and strategies. The author describes the dynamics of this phenomenon and details steps to remedy the situation. Once recognized, he suggests that the manager establish a trusting relationship with the instigator as a prelude to altering the behavior patterns, then transfer the subordinates and reorient the work climate so that independence and responsibility are encouraged. If the instigator is a powerful executive, the author suggests enlisting the support of a countervailing force, such as the government or a union, to guide the organization away from possible self-destructive adventures.

  3. MBO: A Method to the Madness.

    Science.gov (United States)

    Graeff, Todd

    1984-01-01

    The management by objective system defines responsibility and evaluates success by setting and measuring the achievement of objectives. The zero based budgeting system starts budget formation at the $0 point and matches dollar amounts to specific goals. Together, these management concepts help develop an organizational structure. (DF)

  4. Aitajaid sel teekonnal pole / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2005-01-01

    11. märtsil esietendus teatris NO98 ja Sine Loco (A. Türnpu projekt) koostöös lavastus "Inimese teekond", mille lähtematerjaliks on J. Bunyani religioosne teos "Palveränduri tee". Lavastaja ja kokkupanija A. Türnpu

  5. Killud Euroopa jazzisuvest / Madli-Liis Parts

    Index Scriptorium Estoniae

    Parts, Madli-Liis, 1969-

    2008-01-01

    2.-5. juulini Riias toimunud jazzifestivalist "Rigas ritmi",11.-13. juulini Rotterdamis toimunud festivalist "North Sea Jazz", Itaalias Perugias toimunud "Umbria Jazzist" ja Norras Moldes toimunud festivalist. Festivalide korraldusest, kontsertidest, esinemispaikadest, esinejatest

  6. Fiktiivne auhinnagala Lõuna-Prantsusmaal / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2007-01-01

    6.-27. juuli - 61. Avignoni festival. Valitud etendusi Avignonist : Ariane Mnouchkine'i "Les Ephemeres", Faustin Linyekula "Dinosaurus", Fernardo Anuanga "Reis tulevikku", Sasha Waltz "insideout", Galin Stojevi "Genees nr 2", multimeediaalase kunsti- ja teatrigrupi Superamasi "Big 3rd episode. Happy/end", Guy Cassiersi "Mefisto for Ever", Krzysztof Warlikowski "Inglid Ameerikas", Raimund Hoghe tantsuetendus "36, Avenue Georges Mandel"

  7. Ministeeriumid toidavad parasiite / Madli Zobel, Kristina Traks

    Index Scriptorium Estoniae

    Zobel, Madli, 1976-

    2000-01-01

    Ministeeriumid peavad üleval kümneid erialaliitusid, mille mõttekus ja kasutegur on küsitav. Tabel: Raha, mis läheb sel aastal liitude toetuseks. Vastuseks vt. Äripäev Mar/29 lk. 26 P. Teppi art., A. Runge art. Äripäev Mar/31 lk. 27, J. Rausi art. Äripäev Apr/6 lk. 27

  8. Cøliaki og mad uden gluten

    DEFF Research Database (Denmark)

    Borre, Mette; Rasholt, Mia; Rasmussen, Jüri Johannes

    Denne pjece henvender sig til dig, der hos lægen eller på sygehuset har fået konstateret cøliaki, eller som har et barn med cøliaki. Pjecen kan også bruges, når familie, venner, daginstitution, skole og andre skal informeres om sygdommen. Cøliaki er en sygdom i tyndtarmen. Sygdommen behandles liv....... Begynder man på diæten, inden diagnosen er stillet, begynder tyndtarmen at hele, og man risikerer at skulle spise gluten i en længere periode igen, før diagnosen kan stilles. Det kan være svært, hvis man har fået det bedre under diæten....

  9. Socrates and the Madness of Method

    Science.gov (United States)

    Schneider, Jack

    2012-01-01

    What do we know about Socrates and the teaching method that, having taken his name, has become widely used from kindergarten through postgraduate seminars? The practitioners employing so-called Socratic methods include vastly different styles, the author says, noting that "we may be mistaking common phrasing for common practice." The differences…

  10. Acerca do conceito de loucura e seus reflexos na assistência de saúde mental Acerca del concepto de loucura y sus reflejos en la atención de salud mental About the concept of madness and its reflexes on mental health care

    Directory of Open Access Journals (Sweden)

    Lia Carneiro Silveira

    2005-08-01

    Full Text Available Trata-se de reflexão teórica acerca de como se deram historicamente a percepção e a conceituação da loucura e, conseqüentemente, das formas de agir perante ela. Essa reflexão reconstrói a trajetória a partir da concepção da Grécia Antiga até os dias atuais, enfocando principalmente os períodos onde ocorreram mudanças na forma de se perceber e atuar perante essa experiência. Conclui-se que a importância em se conhecer as formas históricas do conceito de loucura reside na possibilidade de se poder desnaturalizar as concepções e refletir acerca da prática que são realizadas hoje na assistência às pessoas em sofrimento mental.Ésta es una reflexión teórica acerca de la percepción histórica y conceptualización de la locura y, por consiguiente, de las maneras de actuar ante ella. Abarcamos desde la concepción de Grecia Antigua hasta los días actuales, enfocando los periodos en donde ocurrieron los cambios en la forma de comprender y actuar ante esa experiencia. Concluimos que la importancia de conocer las formas históricas del concepto de locura reside en la posibilidad de desnaturalizar nuestras concepciones y reflejar sobre nuestra práctica actual en la atención a las personas con sufrimiento mental.This is a theoretical reflection on the historical perception and conceptualization of madness and, consequently, on ways of acting towards it. We start from ancient Greek conceptions and move up to the present days, focusing mainly on those periods when perceptions and actions towards madness changed. We conclude that getting to know the historical forms of the madness concept is important to be able to denaturalize our conceptions and reflect about our current practice in care for patients going through mental suffering.

  11. Un percorso di trasformazione nel nuovo assetto detentivo/riabilitativo post OPG: esposizione di un caso / Un processus de transformation dans le nouveau dispositif d’emprisonnement / de réinsertion après la fermeture des hôpitaux psychiatriques judiciaires : une étude de cas / A process of transformation within the new custodial/rehabilitative framework after the closure of the judicial psychiatric hospitals: a case-study

    Directory of Open Access Journals (Sweden)

    Selvino M.S.

    2017-12-01

    Full Text Available L’articolo illustra il lavoro psicologico-clinico effettuato all’interno della “Articolazione per la Tutela della Salute Mentale in Carcere”, nuovo contesto di cura ed assistenza nato alla luce dei radicali cambiamenti attivati dal processo di superamento degli Ospedali Psichiatrici Giudiziari (OPG e che accoglie soggetti autori di reato affetti da patologia psichiatrica, garantendone un’osservazione costante ed interventi riabilitativi ad alta intensità terapeutica. Il caso presentato, attraverso la narrazione del percorso detentivo/riabilitativo di un soggetto, iniziato con la reclusione in regime ordinario, proseguito con l’assegnazione all’OPG e con il successivo approdo presso l’Articolazione SMC (Salute Mentale in Carcere, ed esitato nel trasferimento in un contesto comunitario, mira ad essere esemplificativo della valenza trasformativa di un approccio rivolto al paziente che, nella gestione della patologia psichiatrica, superi i limiti di un assetto prevalentemente custodialistico, spesso predominante nei pregressi contesti ad essa dedicati, e dia priorità alle finalità terapeutico-riabilitative. L’article décrit le travail clinique-psychologique mené dans le « dispositif pour la protection de la santé mentale en prison » géré par les services locaux de santé de Salerne (Italie. Il s’agit d’un nouveau service de santé mentale et de traitement créé grâce aux changements radicaux apportés par la fermeture des hôpitaux psychiatriques judiciaires en Italie. Ce service accueille les criminels souffrant de pathologies psychiatriques, assurant leur contrôle régulier et des traitements de réadaptation à forte intensité thérapeutique. L’étude de cas présentée dans cet article concerne l’histoire d’une personne initialement détenue en prison, puis transférée dans un hôpital psychiatrique judiciaire et, enfin, accueillie par le « dispositif pour la protection de la santé mentale en prison

  12. Gérer les risques liés au travail durant la grossesse. Vers un nouveau modèle de gestion de la santé et sécurité des travailleuses enceintes Risk Management of Work During Pregnancy: Toward a New Health and Safety Management Model for Pregnant Workers Gestión de riesgos laborales durante el embarazo. Hacia un nuevo modelo de gestión de la salud y la seguridad de trabajadoras embarazadas

    Directory of Open Access Journals (Sweden)

    Romaine Malenfant

    2012-11-01

    Full Text Available Le problème de pénurie de main-d’œuvre dans les centres hospitaliers québécois exige de repenser l’organisation du travail dans le respect du droit de retrait préventif de la travailleuse enceinte. Le recours au droit de retrait préventif offre l’occasion de questionner et de transformer, avec la participation de chacune des parties concernées, les façons de faire qui n’offrent pas une efficacité suffisante sur le plan de la santé et sécurité, de la gestion du personnel et de la production. Un nouveau modèle émerge en ce sens. À partir des résultats d’une recherche effectuée dans le secteur hospitalier de trois régions du Québec, l’article fait ressortir comment l’ajout d’une ressource en prévention, dédiée à l’application du droit de retrait préventif et de son intégration dans un plan d’intervention global en santé au travail, permet d’agir efficacement sur les contraintes ergonomiques et organisationnelles et favorise le maintien en emploi durant la grossesse avec une approche constructive et bénéfique pour les travailleuses et pour l’employeur.The workforce shortage problem in Quebec’s hospitals requires that the re-assignment rights of pregnant workers be respected when reconsidering work organization. The right to re-assignment provides an opportunity to question and improve – with the participation of the involved parties – the efficiency of approaches and methods regarding health and safety, production, and staff management. A new model is emerging as a result. Beginning with results from research carried out in hospitals from three Quebec regions, this paper shows how adding a prevention agent who is in charge of applying re-assignment rights makes it possible to effectively influence ergonomic and organizational constraints and to keep women working during pregnancy with a constructive approach that is beneficial for both workers and employers.La escasez de mano de obra en los

  13. Loucura e complexidade na clínica do cotidiano Locura y Complejidad en la clínica del cotidiano Madness and complexity in the daily life clinic

    Directory of Open Access Journals (Sweden)

    Raul Fernando Sotelo Prandoni

    2006-12-01

    las acciones de salud y salud mental; la creación de espacios fértiles en la conquista de la rehabilitación en salud mental y la calidad en el intercambio de informaciones entre los trabajadores de salud mental que son puntos claves para el avance y consolidación de ese nuevo modelo.This paper has the objective to reflect about the Psychiatrist reform for the conduction to the humanization of the madness and the reflection of an anti-mental hospital approach which adheres to a new understanding of the psychic sufferer as a complex subject and self-subjective. This work is supported in the work of Michel Foucault. We make a qualitative research, being the method of production of datum the interview. The analysis of the datum obtained in the interviews is centered in the Interpretative Analytic Method. We have two statements of the analysis. 1 Autonomy: a therapeutic operating 2 Human rights how possibility of relationship of differences. In this way we can see which changes in the conceptions are gradual and the starting point, are all of us, workers, users and relatives. The logic proposed by the Politic of Mental health, the integration of some projects uniting the actions of health and mental health and the creation of fertile fields in the conquest of the recovery in mental health and the quality in the exchange of information among the workers of mental health are key points in the advance and consolidation of this new model.

  14. The social acceptability of wind turbines: some resident are ready to pay to keep their wind turbines; L'acceptabilite sociale des eoliennes: des riverains prets a payer pour conserver leurs eoliennes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-04-15

    The author proposes a synthesis of a survey performed on four wind farms located in different French regions. It appears that only 5 % of residents feel that wind turbines are disturbing, that a dismantling would be detrimental to the resident well-being, that site expansions are well perceived in terms of social well-being, that residents do not really prefer small wind farms. The author outlines that the obtained results cannot be applied to other sites

  15. Georges Darrieus, inventor of vertical axis wind-turbines; Georges Darrieus, pere des eoliennes a axe vertical

    Energy Technology Data Exchange (ETDEWEB)

    Rogier, E.

    2000-10-01

    This article is a short biography of the French man Georges Darrieus (1888-1979) who invented the vertical wind turbine. G.Darrieus can be considered as the first industrial researcher in France, he was a double authority in sciences and in industry machinery. He presented more than 50 patterns and wrote about 700 scientific and technological articles.

  16. The wind energy, a clean and renewable energy; L'energie eolienne, une energie propre et renouvelable

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    Facing the context of greenhouse gases reduction, the France began a national program of fight against the climatic change, in which the development of the renewable energies plays a major part. Among the renewable energy sources, the wind energy is the only one which is cheap and easily used. After a presentation of the leader of the wind energy in Europe (Germany, Spain and Denmark) and the position of the France, the document details the economical and environmental advantages of the wind energy, as the public opinion concerning this energy source. (A.L.B.)

  17. Gallup poll: wind energy perception in France; Sondage perception de l'energie eolienne en France

    Energy Technology Data Exchange (ETDEWEB)

    Chartier, C. [Institut Synovate, 75 - Paris (France)

    2003-01-01

    This gallup poll was carried out in January 2003 by the Synovate institute on request of the French agency of environment and energy mastery (Ademe). It was made on a representative sample of 2090 people from different French regions, and on two over-samples of people living in the vicinity of wind farms in operation or in construction: 300 people in the Aude region and 230 people in the Finistere region. The wind energy remains widely accepted by French people (87%) and even more in areas close to wind farms (Aude: 98%, Finistere: 99%). The ecological and economical aspect of wind energy is the main advantage put forward (92%) while the aesthetics remains the main drawback (45%). (J.S.)

  18. Impact of wind turbines on bats : literature review; Impacts des eoliennes sur les chauves-souris : revue de litterature

    Energy Technology Data Exchange (ETDEWEB)

    Cote, F.

    2006-09-15

    As wind power development intensifies around the world, concerns are being raised regarding the impact on birds and chiroptera. Studies have been conducted to explore the possible causes of bat morality associated with wind power development in Quebec and to determine possible mitigation strategies. It is expected that wind energy development will increase in the province from 100 MW in 2003 to more than 3,500 MW by 2013. The regions that have high potential for wind energy development in Quebec include the Appalachian corridor, the Lower North Shore, the Magdelaine Islands, Anticosti Island, the Gaspe Peninsula and northern Quebec. The migration patterns of bats have been examined through visual and auditory observations during the springtime reproductive and nesting season as well as in the autumn. Possible causes for bat mortality by wind turbines include seasonal migration routes, light, food and ultrasonic attraction. It was concluded that it is imperative to understand the causes of bat mortality in order to develop possible mitigation measures. 40 refs.

  19. Offshore wind power. Recommendation for a national policy; Energie eolienne en mer. Recommandation pour une politique nationale

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-12-15

    In the framework of the international agreements, the France fixed ambitious objectives of electric power production from renewable energies, and among other the wind power. THe offshore chain of this energy seems to be promising, but the first projects show difficulties, because of reluctance from other sea users, uncertainties on the projects profitability or because of the complexity of the regulatory framework. Thus an inter-departmental group has been constituted in order to discuss these problems. This report is a synthesis of their works. It analyzes the today context and proposes possible orientations. (A.L.B.)

  20. La noción kleiniana de Identificación Proyectiva, piedra fundamental de los abordajes de la locura en la Escuela Inglesa de psicoanálisis The notion of Projective Identification as basis of the approach to madness in the English School of psychoanalysis

    Directory of Open Access Journals (Sweden)

    Lucrecia Aurora Musumeli

    2005-12-01

    the English school have opened, taking as point of departure transference situations in which are present hallucinatory or confusional status of mind, ways of thought that both shed light on a fundamental dimension of de analytic transference and allow to tackle madness in a new way. The cornerstone of this advance was Klein's notion of Projective Identification, whose rejection (denial is jointly responsible of a practice which oscillates between speculations about the ultimate ratio of madness - whose compensation lies in the psychiatric knowledge about psychosis - and therapeutic activism which, at best, is only able to clinically reinstall the coordinates previously unleashed. In Klein's mind, the appearance of Projective Identification hinders the anchorage of self's symbolization, promotes an excess of self-mutilating evacuation (similar to Ferenczi's splitting and weakens symbolization. Although, in Klein's view, the Projective Identification was conceived as a basic defense, it acquires the paradoxical quality of being as openly risky as potentially fruitful, like any operation that tries to revert the same thing that feeds it. Its emergence in the cure demands a conduct that combines both, abstinence and accommodation.

  1. Les pays émergents, nouveau moteur de l'aide internationale | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    11 mars 2014 ... La contribution totale que fait un pays aux pays en développement donne donc une meilleure mesure de sa générosité que le seul montant de l'aide, a conclu Mme Adelman. La compassion est l'affaire de tous dans un pays, et pas uniquement du gouvernement. Kelly Haggart est rédactrice principale au ...

  2. A new type of hybrid vehicle in Japan; Un nouveau type de vehicule hybride au Japon

    Energy Technology Data Exchange (ETDEWEB)

    Henry, P.

    2004-04-01

    During the 37. edition of the Tokyo Motor Show in October 2003, several fuel cell hybrid vehicles were presented by Japanese car makers who grant considerable budgets to develop less polluting vehicles. The trend chosen by Japanese car manufacturers concerns the hybrid system combining fuel cell and battery. Stress has been put also on intelligent systems for navigation and safety but also on the design and comfort. However, even if the environment protection is the main challenge of the Japanese automotive industry, the driving pleasure remains the most profitable medium-term market to be exploitable by industrialists. (J.S.)

  3. Les facteurs de localisation d’un nouveau type d’établissements tertiaires : les datacentres

    Directory of Open Access Journals (Sweden)

    Henry Bakis

    2015-02-01

    Full Text Available Les centres de traitement de données ou datacentres (data centers sont de nouveaux types d’établissements tertiaires rendus nécessaires par suite du développement d’Internet (sites web, cloud. Ils assurent notamment l’hébergement de serveurs (housing d’entreprises ou de particuliers en location ou colocation d’espaces. Cet article tente de présenter ce type d’établissements tertiaires et de mettre l’accent sur leurs enjeux en termes de localisation et d’environnement. Il met notamment l’accent sur leur consommation énergétique.

  4. CIDO 2015 : Des chercheurs tentent de combler le nouveau fossé ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    6 juil. 2015 ... La répartition inégale des ressources technologiques et des séries de données disponibles menace-t-elle la participation des pays en développement à la révolution des données ouvertes? Voilà l'une des nombreuses questions que se posaient les participants à 3e Conférence internationale sur les ...

  5. Babel et le Nouveau Monde Babel and the New World Babel y el Nuevo Mundo

    Directory of Open Access Journals (Sweden)

    Néstor Salamanca Leon

    1996-05-01

    Full Text Available L'analyse de la mythologie des Muiscas fait l'objet d'une réflexion stimulante qui montre à quel point le rêve d'une langue originale en Amérique latine est important.The analysis of the mythology of the Muiscas is at the core of a stimulating reflection which shows the extent of the development of the dream of an original tongue in South-America.El análisis de la mitología de los Muiscas como centro de una estimulante reflexión que permite mostrar hasta qué punto ha podido desarrollarse en América Latina el sueño de una lengua original.

  6. Appropriation d’un nouveau protocole antipaludéen au Sénégal

    Directory of Open Access Journals (Sweden)

    Sidy Ba

    2011-04-01

    Full Text Available Cet article documente le processus de mise en œuvre du Traitement préventif intermittent TPI, une stratégie de prévention du paludisme dont l’administration est couplée au Programme élargi de vaccination (PEV dans les services de santé, les réactions des prestataires, des populations et leurs facteurs explicatifs. Les résultats montrent que l’absence de connaissances adéquates à propos du TPI n’a pas empêché son appropriation par les communautés, dans la mesure où les perceptions lui accordent une valeur pratique et l’intègrent dans les besoins ressentis. C’est pourquoi les enfants ont reçu, dans la grande majorité, les médicaments administrés. Certains comportements en décalage s’expliquent plus par des contraintes, des insuffisances du système de santé et de vaccination que par un refus. Chez les prestataires de soins, l’information a été plus disponible du côté les infirmiers étatiques. Cependant, les processus de détournement et les attitudes d’indifférence étaient plus visibles chez ces derniers. En définitive, l’utilité trouvée à la mesure, les contraintes des environnements professionnels et sociaux dans lesquels évoluent les prestataires, ont déterminé les types de comportements ou usages de cette dernière. Cela montre que l’innovation thérapeutique, au-delà de ses dimensions biomédicales et technologiques, est, une fois soumise à application dans les services de santé, enchâssée dans des réalités professionnelles, individuelles qui influencent les conditions et les modalités de sa mise en œuvre et de son appropriation par les prestataires et les bénéficiaires.Appropriation of a new antimalarial protocol in Senegal: Intermittent Preventive Treatment (IPT coupled to Expanded Programme of Immunization (EPIThis article documents the process of implementation of Intermittent Preventive Treatment, a strategy for preventing malaria whose administration is coupled to Extended Programme of Immunization in health services, feedback from providers, populations and their explanatory factors. The results show that the lack of adequate knowledge about IPT did not prevent its appropriation by communities, to the extent that perceptions give it practical value and include it in the felt needs. This is why children have received, in the vast majority, administered drugs. Some shift in attitudes can be explained more by constraints, shortcomings of the health and immunization system than a refusal. Among care providers, information was more available amongst state-recruited nurses. However, diversion processes and attitudes of indifference were more visible in the latter.Ultimately, the utility found in the measure, the constraints of professional and social environments in which providers operate, have determined the types of behaviors or practices of the latter. This shows that therapeutic innovation, beyond its biomedical and technological dimensions, is, once subjected to application in health services, embedded in professional, individual realities that influence the conditions and modalities for its implementation and its appropriation by providers and beneficiaries.Apropiación de un nuevo protocolo antipalúdico en Senegal: el Tratamiento Preventivo Intermitente (TPI acoplado al Programa Ampliado de Vacunación (PAVEste trabajo documenta el proceso de aplicación del Tratamiento Preventivo Intermitente, una estrategia de prevención del paludismo cuya administración queda acoplada con el PEV en los servicios de sanidad, las reacciones de los suministradores de servicios, de las poblaciones y sus factores explicativos. Los resultados muestran que la ausencia de conocimientos adecuados a propósito del TPI no ha impedido su apropiación por las comunidades, en la medida en que las percepciones le dan un valor práctico y lo integran en las necesidades sentidas. Razón por la que los niños han recibido, en su gran mayoría, los medicamentos administrados. Ciertos comportamientos en desfase se explican más bien por unos imperativos, unas insuficiencias del sistema de sanidad y de vacunación que por una negativa. En los suministradores de servicios de tratamientos, la información ha sido más disponible para los enfermeros estatales. No obstante, los procesos de malversación y las actitudes de indiferencia eran más visibles en estos últimos.En definitiva, la utilidad encontrada en esta medida, los imperativos de los ambientes profesionales y sociales en los que evolucionan los suministradores de servicios han determinado los tipos de comportamientos o usos de esta última. Eso muestra que la innovación terapéutica, más allá de sus dimensiones biomédicas y tecnológicas es, una vez sometida a aplicación en los servicios de sanidad, empotrada en unas realidades profesionales individuales que influencian las condiciones y las modalidades de su aplicación y de su apropiación por los suministradores de servicios y los beneficiarios.

  7. The Tricastin incident: another French psychodrama; L'incident du Tricastin: Un nouveau psychodrame francais

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-15

    The author comments the level 1 incident which occurred on the Tricastin site in July 2008 with the release of 30 cubic meters of a uranium-containing solution in the Rhone river. First, he outlines that the Tricastin is not a nuclear power plant, that uranium if more a chemical toxic product than a radiological toxic product. He briefly discusses the presence of uranium in the environment, and states that the event is actually a non-event which has been in fact magnified by the media, and that the action of anti-nuclear organization on this matter was inadequate

  8. La méthanisation agricole - Champ d'activité nouveau pour l'agriculteur

    OpenAIRE

    Claire Etrillard

    2013-01-01

    Traiter la pollution liée aux déchets et aux effluents en produisant de l'énergie renouvelable. Telle est la promesse de la méthanisation agricole actuellement promue par les pouvoirs publics. Le cadre juridique de la méthanisation à la ferme a de ce fait beaucoup évolué ces derniers temps en France. Désormais, les activités de méthanisation exercées par un exploitant agricole sont réputées agricoles, et à ce titre strictement réglementées. Quant aux produits issus de cette méthanisation, l...

  9. Le LHC va peut-être nous révéler un monde nouveau

    CERN Multimedia

    Huet, Sylvestre

    2006-01-01

    Michel Spiro, Director of the National Institue of Nuclear Physics and Particle Physics of the CNRS was member of the team which discovered the W boson at CERN in 1983: it is what made it possible to Carlo Rubbia and Simon van der Meer to be awarded the Nobel Prize in 1984

  10. Pneumoblastome de l'adulte: rapport d'un nouveau cas et revue de ...

    African Journals Online (AJOL)

    Le blastome pulmonaire décrit surtout chez les enfants, est une tumeur rare. Elle représente 0.25 à 0.5% de toutes les tumeurs pulmonaires avec un pronostic très grave. Sur le plan histologique, il s'agit d'une tumeur à double composante: une composante épithéliale et une composante mésenchymateuse. Cliniquement ...

  11. Adoption et intensification du Nouveau Riz pour l'Afrique en Centrafrique

    Directory of Open Access Journals (Sweden)

    Mbétid-Bessane, E.

    2014-01-01

    Full Text Available Adoption and Intensification of New Rice for Africa in the Central African Republic. The objective of the study is to highlight the determinants of adoption and intensification of Nerica (new rice for Africa varieties in order to propose actions to increase sustainably rice production. To achieve this goal, the working method is based on surveys conducted with two passes with 150 rice farmers in the suburban area of Bangui where two varieties of Nerica (irrigated NL60 and rainfed N7 were disseminated. Descriptive analysis and econometric tools have been used for processing the data collected. The results show that the rate of adoption of the Nerica varieties is 33% after two years of introduction and it is determined by social and institutional variables. The level of intensification by improved seeds and chemical fertilizers is however still low and is determined, beside the institutional and social variables, by economic variables. The most decisive variables of rice intensification are agricultural income and access to credit. Thus, actions to implement should focus firstly on the level of intensification of those who have already adopted the inputs, and secondly on improving adoption rates of the different inputs. These actions will involve (i the capacity building of rice producers by literacy, agricultural training and extension, and (ii improving the business environment through access to credit and a better marketing organization.

  12. Description d’un genre nouveau de la famille des Clérides

    NARCIS (Netherlands)

    Fairmaire, L.

    1887-01-01

    Tarsi quadriarticulati. Prothorax haud marginatus, lateribus cum pleuris confusis. Oculi antice emarginati, subtiliter granulati. Antennæ breves, ab articulo 5° late serratae, articulo 4° brevissimo, ultimo emarginato, apice sat acuto. Palpi omnes articulo ultimo elongato, acuto. Elytra apice

  13. Euscelus spiniger Voss (Coleoptera : Attelabidae : Attelabinae), nouveau ravageur du goyavier (Psidium guajava L., Myrtaceae)

    OpenAIRE

    Couturier, Guy; Delgado, C.

    1995-01-01

    Le coléoptère #Attelabidae Euscelus spriniger$ Voss est cité pour la première fois comme nuisible au goyavier (#Psidium guajava$). Les observations ont été réalisées dans la région d'Iquitos, en Amazoniepéruvienne. (Résumé d'auteur)

  14. Évaluation du nouveau programme d'études du College of Health ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ces changements étaient jugés nécessaires pour préparer les professionnels de la santé aux nouvelles exigences de la prestation de services de santé décentralisés, pour juguler les nouvelles pandémies comme celles du VIH/sida et du virus Ébola, ainsi que pour répondre aux besoins des malades dans les zones ...

  15. La dialectique du nouveau et du même dans God's Grace de Bernard Malamud

    OpenAIRE

    Chard-Hutchinson, Martine

    2017-01-01

    What's the use avoiding rats and horror, hiding from Cops and dentists' drills ? Somebody will invent Buchenwald next door. Alan Ginzberg "If it's all right with you," he addressed the gorilla in gratitude, "I'd like to call you George after my late wife's father, who was an accomplished dentist, a wonderful man. He often fixed people's teeth for nothing." Bernard Malamud God's Grace, le dernier roman achevé de Bernard Malamud, est une histoire "pleine de fureur et de bruit" qui se présente ...

  16. Nouveau Programme de Troisième Cycle Interuniversitaire : Phase 2

    International Development Research Centre (IDRC) Digital Library (Canada)

    Social sciences in sub-Saharan Africa are severely underresourced. But an infusion of graduates at the master's and PhD levels in 18 francophone countries in West and Central Africa will increase the region's contribution to global social sciences, especially economics. According to UNESCO's 2010 World Social Science ...

  17. Nouveau télécentre de Manhiça (Mozambique) | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Addressing Africa's unmet need for family planning by intensifying sexual and reproductive and adolescent health research. ... Special journal issue highlights IDRC-supported findings on women's paid work. Policy in Focus publishes a special issue profiling evidence to empower women in the labour market.

  18. Élaboration et distribution d'un nouveau vaccin contre la babésiose ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    13 mars 2018 ... Ce projet utilisera la biotechnologie de pointe pour produire un vaccin à double action : il ... Non seulement, le vaccin préviendra la maladie et la mort des suites de la ... Addressing obesity in South Africa through taxation.

  19. Élaboration et distribution d'un nouveau vaccin contre la babésiose ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    13 mars 2018 ... La criminalité et la pauvreté au Ghana urbain. La manière dont la criminalité et la pauvreté interagissent a été étudiée et débattue dans la littérature de recherche occidentale, mais on sait pe. Voir davantageLa criminalité et la pauvreté au Ghana urbain · Ce que nous faisons · Financement · Ressources ...

  20. Un meilleur accès à la justice pour tous : un nouveau rapport fournit ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Prévenir la violence tout en réduisant la pauvreté. Est-ce qu'un programme de réduction de la pauvreté peut aussi contribuer à réduire la criminalité et la violence? Voir davantagePrévenir la violence tout en réduisant la pauvreté ...

  1. L’écologie industrielle : nouveau paradigme ou slogan à la mode

    Directory of Open Access Journals (Sweden)

    Raphaël Larrère

    2006-12-01

    Full Text Available The project of industrial ecology is to offer guidance to the industrial systems, in order that they function in a cyclic way. After having developed the principal arguments which militate in favour of industrial ecology and having offered an exemplary case, I will examine the limits of the analogy between industrial systems and ecological systems, thus expressing the circumstances and the factors which preclude the former to function at least roughly like the latter. The exemplary case having shown that technological effectiveness is not enough to grant a competitive advantage, I will finish by offering support to the contention that one can regard industrial ecology as a form of Utopia.

  2. Validation d'un nouveau calcul de reference en evolution pour les reacteurs thermiques

    Science.gov (United States)

    Canbakan, Axel

    Resonance self-shielding calculations are an essential component of a deterministic lattice code calculation. Even if their aim is to correct the cross sections deviation, they introduce a non negligible error in evaluated parameters such as the flux. Until now, French studies for light water reactors are based on effective reaction rates obtained using an equivalence in dilution technique. With the increase of computing capacities, this method starts to show its limits in precision and can be replaced by a subgroup method. Originally used for fast neutron reactor calculations, the subgroup method has many advantages such as using an exact slowing down equation. The aim of this thesis is to suggest a validation as precise as possible without burnup, and then with an isotopic depletion study for the subgroup method. In the end, users interested in implementing a subgroup method in their scheme for Pressurized Water Reactors can rely on this thesis to justify their modelization choices. Moreover, other parameters are validated to suggest a new reference scheme for fast execution and precise results. These new techniques are implemented in the French lattice scheme SHEM-MOC, composed of a Method Of Characteristics flux calculation and a SHEM-like 281-energy group mesh. First, the libraries processed by the CEA are compared. Then, this thesis suggests the most suitable energetic discretization for a subgroup method. Finally, other techniques such as the representation of the anisotropy of the scattering sources and the spatial representation of the source in the MOC calculation are studied. A DRAGON5 scheme is also validated as it shows interesting elements: the DRAGON5 subgroup method is run with a 295-eenergy group mesh (compared to 361 groups for APOLLO2). There are two reasons to use this code. The first involves offering a new reference lattice scheme for Pressurized Water Reactors to DRAGON5 users. The second is to study parameters that are not available in APOLLO2 such as self-shielding in a temperature gradient and using a flux calculation based on MOC in the self-shielding part of the simulation. This thesis concludes that: (1) The subgroup method is at least more precise than a technique based on effective reaction rates, only if we use a 361-energy group mesh; (2) MOC with a linear source in a geometrical region gives better results than a MOC with a constant model. A moderator discretization is compulsory; (3) A P3 choc law is satisfactory, ensuring a coherence with 2D full core calculations; (4) SHEM295 is viable with a Subgroup Projection Method for DRAGON5.

  3. Vers un nouveau théâtre politique: William Kentridge et les discours transculturels

    Directory of Open Access Journals (Sweden)

    Liviu DOSPINESCU

    2006-12-01

    Full Text Available This paper is an exploration of what seems to affirm itself as a new form of political theatre in William Kentridge’s work at the Handspring Puppet Company, based in Cape Town (South Africa. Within this framework, I will focus on those aspects of production through which theatricality finds a more silent, yet more effective way to expose the social, cultural and political landscapes of South Africa. There seems to be a link between Kentridge’s multi- and even transdisciplinary artistic approach and the south-african transculturality, which may explain some of the aesthetical, as well as the political sides of theatrical performances, such as Woyzeck on the Highveld (1992, Faustus in Africa (1994, and Ubu and the Truth Commission. These pieces will be analyzed here in order to better understand the moods, as well as the dynamics of the south-african shifting identities and their implications as a dramatic theme on the audience’s reception of what I call a silent politics. In these productions, the political discourse emerges out of the self-referential theme of identity and of its alterations, both at the formal and symbolical levels, as a subtle and effective performative act.

  4. Le CERN affronte le nouveau millénaire avec confiance

    CERN Multimedia

    CERN Press Office. Geneva

    1999-01-01

    The CERN Council, where the representatives of the 20 Member States of the Organization decide on scientific programmes and financial resources, held its 114th session on 17 December under the chairmanship of Dr.Hans Eschelbacher.

  5. 45 Nouveau concept de séchage et de fumage artisanal des aliments

    African Journals Online (AJOL)

    PR BOKO

    and wood of pyrolysis; it is of more modular and built with materials and standard tools of the masonry and the boilermaking. He allows to separate in two different phases, the operations of drying and smoking. The drying of fishes is made by convection, conduction and radiation with smoke ducts. Therefore, we have a.

  6. CIDO 2015 : Des chercheurs tentent de combler le nouveau fossé ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    6 juil. 2015 ... ... pays plus pauvres du capital humain pour transformer des données ouvertes ... pas une croissance récente et une demande accrue de toilettes publiques. ... CIDO 2015 : Présentation du potentiel économique et social des ...

  7. LE MEDICAMENT DU MOIS. Vedolizumab (Entyvio(R)), nouveau traitement des maladies inflammatoires intestinales.

    OpenAIRE

    Van Kemseke, Catherine; Louis, Edouard; Reenaers, Catherine

    2015-01-01

    Anti-TNF agents are highly effective in treating inflammatory bowel diseases, but loss of response and side-effects leading to drug interruption are often reported. New molecules are needed to treat these patients. Vedolizumab is a fully humanized anti-body inhibiting the migration of circulating lymphocytes to the gut by binding the integrin alpha4beta7. In ulcerative colitis, clinical response, remission and mucosal healing were observed at 6 weeks in 47%, 17% and 40% of the patients, respe...

  8. L'intelligence artificielle : nouveau levier de croissance pour les industries pharmaceutiques

    OpenAIRE

    Habbal , Lina

    2017-01-01

    La présente thèse étudie les applications de l’intelligence artificielle dans les différents aspects de la stratégie des industries de santé ainsi que leur apport.En effet, depuis les années 2000, les laboratoires pharmaceutiques font face à une crise liée à une perte d’efficacité générale en termes d’innovation et la tombée de brevet de molécules phares dans le domaine publique.Les décisions prises dans la gestion de cette crise, notamment la multiplication des mouvements de fusion acquisiti...

  9. 25 Utilisation d'un nouveau bio-floculant extrait de cactus marocain ...

    African Journals Online (AJOL)

    AKA BOKO

    chimique (coagulation floculation) afin de traiter des rejets liquides chargés en chrome. (VI). Ce bio-floculant nous a permis de réduire la turbidité d'un effluent industriel, en .... Spectrophotomètre UV-Visible, type UV-160 mode SHIMADZU.

  10. 2005 results making progress again; Resultats 2005 a nouveau en progression

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-03-15

    This document presents and analyses the financial and economical statements of the AREVA Group in 2005, for each division. The organic growth of sales revenue, the current operating income, the operating income, the net income up and the increased dividend proposed at the General Meeting of shareholders are discussed. (A.L.B.)

  11. Le nouveau modèle africain | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    22 juil. 2011 ... Or, ce serait rater le bateau que de ne pas s'engager dans la voie tout autre que les Africains proposent maintenant — à savoir se défaire du syndrome de la dépendance qui afflige l'Afrique depuis des décennies. Le Canada et les autres pays riches du Nord reconnaissent généralement qu'ils ne peuvent ...

  12. New control system: net communications on VAX; Nouveau systeme de controle: communications reseau sur VAX

    Energy Technology Data Exchange (ETDEWEB)

    David, L; Maugeais, C

    1993-12-31

    The control system is made of five different types of processors: a server (VAX 3800), stations (VS4000) as setting interfaces for operators, CAMAC VANTAGE controllers, VME controllers and industrial programmable automates. These automates are treated with the IMAGIN supervision software and with the OSI communication protocol. All the processors are of the VAX family and use DECNET communication protocol on ETHERNET net. (A.B.). 3 figs.

  13. Le nouveau visage de la philanthropie en Inde | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Connectez-vous avec Nirojan sur LinkedIn. La philanthropie est en hausse en Inde et le phénomène devrait continuer à croître. La nouvelle richesse transforme également le visage des dons de charité et retient l'attention du public. Par conséquent, le nombre de conseillers en philanthropie augmente aussi. La relation ...

  14. Le nouveau site Web facilitera l'enregistrement des événements ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ESEC) dans les pays en développement nécessite une mise en commun des connaissances, des conseils d'expert, des ressources pratiques et du soutien. Le Centre d'excellence sur les systèmes ESEC est heureux de ...

  15. Culture engineering examination and metabolism flux distribution system analysis for madding to convert into poly {beta}- hydroxybutyric acid (PHB) using the hydrogen bacteria of organic acid got in liquid-phase oxidation of lignite; Kattan no ekiso sanka de erareru yukisan wo suiso saikin wo riyoshite pori {beta}-hidorokishi rakusan(PHB) ni henkan saseru tameno baiyo kogakuteki kento to taisha ryusoku bunpu shisutemu kaiseki

    Energy Technology Data Exchange (ETDEWEB)

    Tsujimoto, Kinko; Seki, Suito; Shimizu, Kazuyuki; Mae, Kazuhiro; Miura, Koichi

    1999-04-05

    The culture engineering examination for madding to convert into poly {beta} - hydroxy Wisteria (PHB) which glycolic acid. Acetic acid, ant acid, malonic acid got in liquid-phase oxidation of lignite are raw material of biodegradable plastic using hydrogen bacteria Alcaligenes eutrophus was carried out. It was proven that acetic acid was the most efficiently converted into the PHB as a result of cultivating these organic acid as a single carbon source. And, it was utilized to the bacterial cell at the order of ant acid, acetic acid, glycolic acid, when it was cultivated in mixing organic acid, and it was proven to convert into the PHB. Though the malonic acid was not utilized for the bacterial cell breeding, it was indicated that as the result which analyzed metabolism flow distribution by calculating using the culture data, the succinate dehydrogenase of the tricarboxylic acid (TCA) circuit received competitive inhibition, when this is added in culture middle point, and that the flux of griot lysyl acid route and gluconeogenesis route lowers. And, it was proven that it was utilized in the route which comes to the PHB synthesis from acetoacetyl CoA with the lowering of the ammonia concentration on NADPH produced from the isocitric acid, though it was prior consumed to the glutamic acid of tricarboxylic acid cycle in the route, if ammonia concentration is high. (translated by NEDO)

  16. Third order TRANSPORT with MAD [Methodical Accelerator Design] input

    International Nuclear Information System (INIS)

    Carey, D.C.

    1988-01-01

    This paper describes computer-aided design codes for particle accelerators. Among the topics discussed are: input beam description; parameters and algebraic expressions; the physical elements; beam lines; operations; and third-order transfer matrix

  17. Clinical and laboratory findings in mad honey poisoning: A single ...

    African Journals Online (AJOL)

    In the evaluation of the patients' heart rhythms on admission to the emergency room, nine (56.3%) patients had sinus bradycardia, three (18.8%) patients had nodal rhythm, two (12.5%) patients had first degree atrioventricular block, and two (12.5%) patients had atrial fibrillation. Atropine 1.1 ± 0.4 mg and saline 1125 ± 465 ...

  18. Making and Mining Intellectual Capital: Method or Madness?

    Science.gov (United States)

    Cohen, Stephen L.; Backer, Nena K.

    1999-01-01

    A process for creating and managing intellectual capital within an organization has the following stages: (1) inquire about causes and effects and infer the implications; (2) invent solutions and inspire others with a cause for change; and (3) install solutions and inspect over the long term to see what is and is not working. (JOW)

  19. A Case for Preserving the Diversity of Madness

    Science.gov (United States)

    Sarrett, Jennifer C.; Kushner, Howard I.

    2011-01-01

    Watters questions the universality of mental illness and warns of the harms that accompany the exportation of Western typologies to non-Western cultures. He is particularly concerned that these effects will be exacerbated by the upcoming revisions of the "Diagnostic and Statistical Manual of Mental Disorders" ("DSM-V").…

  20. Method or Madness: Federal Oversight Structures for Critical Infrastructure Protection

    Science.gov (United States)

    2007-12-01

    daughters, Amber and Lauren, who always say just the right things to keep this all in perspective. Bike rides and soccer games helped to provide just...security perspective, is shared by the U.S. Department of Agriculture and the Department of Health and Human Services. The USDA monitors the meat ... poultry , and egg sectors, while HHS oversees production of all other food products.90 HHS implements a two-prong strategy to achieve a safe and

  1. The hysterical body. Madness and discipline in the contemporary dance

    Directory of Open Access Journals (Sweden)

    Roberto Giambrone

    2011-12-01

    Full Text Available Disappeared from the medical manuals and hospitals, hysteria has come on stage. That is a natural result for a phenomenon born between the end of the 19th and the beginning of 20th century and plainly marked by theatrical characteristics. As from the experiments carried out by Charcot at the Salpêtrière clinic – where the performances of the hysterical patients were shown to an audience made by doctors, intellectuals, artists and curious persons – to the German expressive dance, to Tanztheater and to the recent performances of the European dance-theatre, the hysterical gesture dominates the twentieth-century and contemporary theatre. At the bottom of this phenomenon, it is possible to find reasons and needs between art and life, and the search – never interrupted during the 20th century – for a theatrical discipline that rules the chaos of Dionysiac impulse.

  2. Mad on radium New Zealand in the atomic age

    CERN Document Server

    Priestley, Rebecca

    2012-01-01

    Although New Zealander Lord Rutherford was the first to split the atom, the country has since been known around the world for its nuclear-free stance. In this engaging and accessible book, an alternative history is revealed of ""nuclear New Zealand""-when there was much enthusiasm for nuclear science and technology. From the first users of X-rays and radium in medicine to the plans for a nuclear power station on the Kaipara Harbour, this account uncovers the long and rich history of New Zealanders' engagement with the nuclear world and the roots

  3. What Mad Pursuit: A Personal View of Scientific Discovery by ...

    Indian Academy of Sciences (India)

    on his further research work in molecular biology, including the genetic code, the triplet- base sequence for amino acids, the "central dogma", messenger RNA, etc. Again he concen tra tes more on the way research is done and the several blind alleys, especially their difficulty in identifying the right RNA that plays the role of ...

  4. [Armourer and mad cow disease: images of veterinarians in music].

    Science.gov (United States)

    Schäffer, J

    2001-01-01

    This contribution is not about animals in music; it rather attempts to describe how veterinary medicine as a discipline and veterinarians as representatives of the profession are perceived of and portrayed in music. Aside from Gioacchino Rossini's "Barber of Seville", in which Count Almaviva impersonates a veterinarian of the day, the most sympathetic veterinarian character ever created by a lyricist or composer in surely Hans Stadinger, the "armourer" and vet in Albert Lortzings opera. In other musical genres such as artsongs and folksongs, the only such figure worthy of musical interpretation seems to have been those masters of the fiery forge who were also wise in the veterinary healing arts. In the past 20 years vets and veterinary medicine have been included in new musical trends: There are musicals and radio plays in which even the youngest members of the audience are exposed to the veterinarian profession. A number of pop groups are also to be mentioned here. For example, animal welfare has been thematized by punk rockers, and a pop group for Hamburg has put a medieval horse blessing to music. Last but not least, a number of vets in Berlin turn their everyday troubles and worries into musical parodies.

  5. Kriisimängud Berliinis : "Theatertreffen 2010" / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2010-01-01

    7.-24. maini Berliinis toimunud teatrifestivalist "Theatertreffen". Lavastustest "Räpased, koledad, alatud" (lav. Karin Beier), "Riesenbutzbach. Igavene koloonia" (lav. Marthaler), Dennis Kelly "Ma olen nii armunud, et võiksin oksendada" (lav. Stephan Kimmig), Roland Schimmelpfennigiti "Kuldne draakon" (lav. R. Schimmelpfennig), Peter Handke "Tund, mil me üksteist midagi ei teadnud" (lav. Viktor Bodo) ja Elfride Jelineki tekstide põhjal "Kaupmehe kontraht" (lav. Nicolas Stemann)

  6. Metasynthetic Madness: What Kind of Monster Have We Created?

    Science.gov (United States)

    Thorne, Sally

    2017-01-01

    From its origins in the 1990s, the qualitative health research metasynthesis project represented a methodological maneuver to capitalize on a growing investment in qualitatively derived study reports to create an interactive dialogue among them that would surface expanded insights about complex human phenomena. However, newer forms positioning themselves as qualitative metasynthesis but representing a much more technical and theoretically superficial form of scholarly enterprise have begun to appear in the health research literature. It seems imperative that we think through the implications of this trend and determine whether it is to be afforded the credibility of being a form of qualitative scholarship and, if so, what kind of scholarship it represents. As the standardization trend in synthesis research marches forward, we will need clarity and a strong sense of purpose if we are to preserve the essence of what the qualitative metasynthesis project was intended to be all about. © The Author(s) 2016.

  7. An undignified bioethics: there is no method in this madness.

    Science.gov (United States)

    De Melo-Martín, Inmaculada

    2012-05-01

    In a recent article, Alasdair Cochrane argues for the need to have an undignified bioethics. His is not, of course, a call to transform bioethics into an inelegant, pathetic discipline, or one failing to meet appropriate disciplinary standards. His is a call to simply eliminate the concept of human dignity from bioethical discourse. Here I argue that he fails to make his case. I first show that several of the flaws that Cochrane identifies are not flaws of the conceptions of dignity he discusses but rather flaws of his, often problematic, understanding of such conceptions. Second, I argue that Cochrane's case against the concept of human dignity goes too far. I thus show that were one to agree that these are indeed flaws that require that we discard our ethical concepts, then following Cochrane's recommendations would commit us not only to an undignified bioethics, i.e. a bioethics without dignity, but to a bioethics without much ethics at all. © 2010 Blackwell Publishing Ltd.

  8. Fiktiivne auhinnagala Lõuna-Prantsusmaal II / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2009-01-01

    Muljeid tänavusest 63. Avignoni teatrifestivalist. Pikemalt järgmistest etendustest: Krzysztof Warlikowski "(A)pollonia", Claude Regy "Ode Maritime" (Fernando Pessoa poeemi järgi), Frederico Leoni "Yo en el futuro" ("Mina tulevikus"), Thierry Bedard'i "Geko košmaarid" jt.

  9. Mad Kids: How To Help Your Child Manage Anger.

    Science.gov (United States)

    Beekman, Susan; Holmes, Jeanne

    2002-01-01

    Children move through the same anger cycle as adults and need similar coping strategies and problem solving skills. This paper presents pre-anger approaches, discussing what to do before the "boil-over" occurs, when the boiling point is reached, and after the boil-over. A sidebar presents a list of questions and activities parents can use with…

  10. On the Madness of Lecturing on Gender: A Psychoanalytic Discussion

    Science.gov (United States)

    Britzman, Deborah P.

    2010-01-01

    This essay comments on the emotional difficulties psychoanalytic discussion introduces to conceptualising the poesis of gender through its reconsideration of the valence of aggression and its development in psychical reality. It returns to the 1936 lectures on the emotional life of gender given by Melanie Klein and Joan Riviere to a public about…

  11. The 'mad scientists': psychoanalysis, dream and virtual reality.

    Science.gov (United States)

    Leclaire, Marie

    2003-04-01

    The author explores the concept of reality-testing as a means of assessing the relationship with reality that prevails in dream and in virtual reality. Based on a model developed by Jean Laplanche, she compares these activities in detail in order to determine their respective independence from the function of reality-testing. By carefully examining the concept of hallucination in the writings of Freud and Daniel Dennett, the author seeks to pinpoint the specific modalities of interaction between perceptions, ideas, wishes and actions that converge in the 'belief' and in the 'sense of reality'. The paper's main thesis consists of the distinction that it draws between immediacy-testing and reality-testing, with the further argument that this distinction not only dissipates the conceptual vagueness that generally surrounds the latter of the two concepts but also that it promotes a more precise analysis of the function of reality in dream and in virtual reality.

  12. Darwin's Invention: Inheritance & the "Mad Dream" of Pangenesis

    Science.gov (United States)

    McComas, William F.

    2012-01-01

    This article recounts the story of the development of pangenesis, a principle proposed by Charles Darwin to describe the rules of inheritance and the source of new variation, two concepts vital to his proposal of evolution by natural selection. Historical accounts such as this are infrequently included in texts and classroom discussions but can…

  13. The Mad Genius Stereotype: Still Alive and Well

    Directory of Open Access Journals (Sweden)

    Tanja Gabriele eBaudson

    2016-03-01

    Full Text Available Scientists and laypeople agree on high ability as a defining feature of giftedness. Yet their views on gifted people’s socioemotional characteristics diverge. Most studies find the gifted to be similar or slightly superior to average-ability persons in these domains (harmony hypothesis. However, subjective conceptions and media representations, most of which have focused on gifted children and youth, stress the socioemotional downsides of giftedness (disharmony hypothesis, affecting highly able individuals and those around them, thus hampering individual development. To date, most studies on gifted stereotypes have examined selective samples, mostly teachers. The present study is the first to provide representative data on conceptions of gifted individuals in general. A brief survey of 1,029 German adults assessed quality and prevalence of stereotypes about gifted individuals, without an explicit focus on children and/or adolescents. Latent class analysis revealed two conceptions of giftedness, with twice as many disharmonious than harmonious raters. Male gender, single parenthood, unemployment, higher income or negative attitudes towards the gifted predicted disharmonious ratings. However, effects were small, suggesting future studies look deeper into the processes of stereotype formation and maintenance.

  14. Clinical and laboratory findings in mad honey poisoning: A single ...

    African Journals Online (AJOL)

    2014-03-15

    Mar 15, 2014 ... [2] These symptoms include a burning sensation in the throat, itching in the mouth and nose, redness on the skin and eyes, vertigo and ... on levotiron therapy and two patients with known valvular heart disease were excluded.

  15. Kriteerium - märkimisväärne / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2006-01-01

    5.-21. maini Berliinis toimunud festivalist Theatertreffen. Vaatluse all lavastused - Friedrich Schilleri näidenditriloogia "Wallenstein" põhjal tehtud dokumentaalne lavastus (autorid Helgard Haug ja Daniel Wetzel), "Der Kick" ("Löök", lavastaja Andreas Veiel), ameerika koreograafi William Forsythe'i tantsulavastus "The Atmospheric Studies", Dimiter Gotscheffi Tshehhovi tõlgendus "Ivanov", Jürgen Goschi Macbeth" ja "Kolm õde" ning Thomas Ostermeieri Ibseni tõlgendus "Hedda Gabler"

  16. Madness and the movies: an undergraduate module for medical students.

    Science.gov (United States)

    Datta, Vivek

    2009-06-01

    Films featuring psychiatrists, psychiatry and the mentally ill abound, for better or for worse. The use of cinema in postgraduate psychiatry training has been gaining increasing acceptability, but its potential for use in undergraduate psychiatry has received little attention in the literature. This paper reports on the rationale behind, and medical students' responses to a special study module for third year medical students at King's College London, which utilized movies to highlight the significance of the social, cultural and historical context in shaping representations of mental illness, psychiatry, and psychiatrists. Medical students were very receptive to the use of film as an educational tool and able to understand both the benefits and limitations. They found the module enjoyable, and subjectively rated their knowledge of psychiatric topics and the history of psychiatry as significantly improved. The results presented are course feedback from medical students (n = 8) who completed the module. Although our findings provide provisional support for the use of film as an educational tool in undergraduate psychiatry, more systematic research is needed to delineate the potential role of cinema in undergraduate psychiatric education.

  17. Anger in Academic Twitter: Sharing, Caring, and Getting Mad Online

    Directory of Open Access Journals (Sweden)

    Karen Gregory

    2018-01-01

    Full Text Available This article examines two different cases or “events” in Twitter to understand the role that negative emotions play in online discussions of academic labor. As academic labor conditions deteriorate and academics take to online spaces, they do so to critique, connect, and organize. We suggest that negative emotions may play a productive role in raising awareness of labor issues, as well as serving as a site for organizing across academic hierarchies and beyond the university. Additionally, negative emotions may fuel the production of new networks, personal, and professional connections. However, as we show, anger online can also provoke substantive repercussions, both personally and institutionally. We suggest that paying attention to the role that negative emotions play on Twitter can help academics gain a better sense of how to use their digital labor for collective action.

  18. Desperate remedies: a Gothic tale of madness and modern medicine.

    Science.gov (United States)

    Scull, A

    1987-08-01

    The theory that many diseases were produced by focal infection or chronic sepsis enjoyed a brief vogue in general medicine in the first quarter of the twentieth century. This paper explores its practical applications in psychiatry, which extended well into the 1930s. The analysis focuses particularly closely on the activities of Henry A. Cotton at the Trenton State Hospital in New Jersey.

  19. [Madness, poverty and society: When poverty becomes mental illness].

    Science.gov (United States)

    Rousseaux, Andrés

    2016-03-01

    The aim of this article is to review the literature on the relationship between homeless and serious mental illness. For both concepts there are different definitions, which will be promptly worked according to the analysis. The study of this issue, particularly outside the scope of our country just highlights the lack of information about this topic in our country. In addition, the following work aims to discuss the relationship between homeless and serious mental illness, as well as a new perspective of work with respect to this issue.

  20. Madness and sanity at the time of Indian independence

    Science.gov (United States)

    Jain, Sanjeev; Murthy, Pratima; Sarin, Alok

    2016-01-01

    The backdrop of the Indian Independence offers glimpses of many ‘metaphors of madness’. In this article, we explore this through a few instances, starting from 1857, around the time of the First War of Independence, to 1947, when India became an independent nation. Such metaphors have their parallels both in historical as well as in contemporary times, where instances of one man's imagination becoming another's concept of irrationality and insanity continue. PMID:28066017

  1. Mad scientist: the unique case of a published delusion.

    Science.gov (United States)

    Shelomi, Matan

    2013-06-01

    In 1951, entomologist Jay Traver published in the Proceedings of the Entomological Society of Washington her personal experiences with a mite infestation of her scalp that resisted all treatment and was undetectable to anyone other than herself. Traver is recognized as having suffered from Delusory Parasitosis: her paper shows her to be a textbook case of the condition. The Traver paper is unique in the scientific literature in that its conclusions may be based on data that was unconsciously fabricated by the author's mind. The paper may merit retraction on the grounds of error or even scientific misconduct "by reason of insanity," but such a retraction raises the issue of discrimination against the mentally ill. This article asks what responsibilities journals have when faced with delusions disguised as science, what right editors have to question the sanity of an author, and what should be done about the Traver paper itself. By placing higher emphasis on article content than author identity, scientific integrity is maintained and a balance is struck between avoiding discrimination against the mentally ill and not preventing patients from seeking needed treatment.

  2. Public outcry: madness masks method on Manhattan's energy exchange

    International Nuclear Information System (INIS)

    Faulkner, P.

    2000-01-01

    Operation of the NYMEX, a division of the New York Mercantile Exchange that deals almost exclusively in crude oil, heating oil, natural gas, electricity, propane, platinum and palladium trading, is described. The NYMEX where the big forces affecting the market such as OPEC, rising demands, limited oil production and tanker capacity, lagging natural gas supplies, pipeline bottlenecks, and cold snaps are translated into economic values, is considered by insiders as the best guarantee against under- or over-pricing, despite the appearance of bedlam and complete chaos. They consider commodity trading a service rather than an added risk in the energy industry. i. e. the NYMEX is seen as a model of order for transactions on a huge scale, aimed at establishing the value, at any given time under any given circumstances, of standardized energy commodities and sales-volume contracts at agreed points. NYMEX's chief strength is that it provides a completely visible and continuous measurement of value. It is also a factory, generating multiple financial instruments for hedging against risks of unfavorable price movements in the future. The anonymity of the buyers and sellers directing the traders is considered a crucial element of the system, ensuring that the market is about the commodity, not about who is producing or using it. Hedging is a key service wherein sellers (mostly oil companies) sell futures contracts to lock in prices to protect their sources of revenue, should market values fall. Buyers make the deals because they believe that prices will go the other way. Industry insiders maintain that hedgers do not try to make a killing on the market. That is the realm of speculators who are most often high income amateurs. By taking the opposite sides of bids or offers, they provide the market with liquidity

  3. MAD with aliens? Interstellar deterrence and its implications

    Science.gov (United States)

    Korhonen, Janne M.

    2013-05-01

    The possibility that extraterrestrial intelligences (ETIs) could be hostile to humanity has been raised as a reason to avoid even trying to contact ETIs. However, there is a distinct shortage of analytical discussion about the risks of an attack, perhaps because of an implicit premise that we cannot analyze the decision making of an alien civilization. This paper argues that we can draw some inferences from the history of the Cold War and nuclear deterrence in order to show that at least some attack scenarios are likely to be exaggerated. In particular, it would seem to be unlikely that the humanity would be attacked simply because it might, sometime in the future, present a threat to the ETI. Even if communication proves to be difficult, rational decision-makers should avoid unprovoked attacks, because their success would be very difficult to assure. In general, it seems believable that interstellar conflicts between civilizations would remain rare. The findings advise caution for proposed interstellar missions, however, as starfaring capability itself might be seen as a threat. On the other hand, attempting to contact ETIs seems to be a relatively low-risk strategy: paranoid ETIs must also consider the possibility that the messages are a deception designed to lure out hostile civilizations and preemptively destroy them.

  4. Marine Activity Dynamics (M.A.D.). Unit S.

    Science.gov (United States)

    Rhode Island State Dept. of Education, Providence. Education Information Center.

    This curriculum guide describes an activity-oriented marine study program, designed for use with middle school children (grade 5). The content focuses primarily upon the life sciences, with some emphasis on chemistry and geology. Following the development of a rationale for the inclusion of marine sciences in the school curriculum, a middle…

  5. Dokumentaalsusest teatris 2015. aasta näitel / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2016-01-01

    Dokumentaalteatri olemusest ning 2015. aastal esietendunud lavastustest "Kodumaa karjed" (NO99), "45 339 km² raba" (Endla), "non-sto SETO" (Taarka pärimusteater), "5 grammi sisemist rahu" (Must Kast), "Õpetaja Tammiku rehabiliteerimine" (Kinoteater), "1i" (Nukuteater), "Ma olen Ivo Linna" (eraprojekt), "Mamma lood" (MTÜ Hiiu Öko), "Kehameel" (Teatri- ja Muusikamuuseum), "kokku kukkumise hetk" (Tartu Uus Teater), "Baskin ehk Nalja põhivormid" (Tartu Uus Teater), "Ajarefrään" (Nukuteater), "Tõelised naised, tõelised mehed ja tõelised teised" (Vaba Lava), "sugu: N" (Vaba Lava), "Fantastika" (NO99)

  6. Globalizing Education, Educating the Local: How Method Made Us Mad

    Science.gov (United States)

    Stronach, Ian

    2011-01-01

    This book offers a critical and deconstructive account of global discourses on education, arguing that these overblown "hypernarratives" are neither economically, technically nor philosophically defensible. Nor even sane. Their "mythic economic instrumentalism" mimic rather than meet the economic needs of global capitalism in…

  7. Taking MAD to the extreme: ultrafast protein structure determination

    International Nuclear Information System (INIS)

    Walsh, M.A.; Dementieva, I.; Evans, G.; Sanishvili, R.; Joachimiak, A.

    1999-01-01

    Multiwavelength anomalous diffraction data were measured in 23 min from a 16 kDa selenomethionyl-substituted protein, producing experimental phases to 2.25 (angstrom) resolution. The data were collected on a mosaic 3 x 3 charge-coupled device using undulator radiation from the Structural Biology Center 19ID beamline at the Argonne National Laboratory's Advanced Photon Source. The phases were independently obtained semiautomatically by two crystallographic program suites, CCP4 and CNS. The quality and speed of this data acquisition exemplify the opportunities at third-generation synchrotron sources for high-throughput protein crystal structure determination

  8. MAD with Aliens? Interstellar deterrence and its implications

    OpenAIRE

    Korhonen, Janne M.

    2013-01-01

    The possibility that extraterrestrial intelligences (ETIs) could be hostile to humanity has been raised as a reason to avoid even trying to contact ETIs. However, there is a distinct shortage of analytical discussion about the risks of an attack, perhaps because of an implicit premise that we cannot analyze the decision making of an alien civilization. This paper argues that we can draw some inferences from the history of the Cold War and nuclear deterrence in order to show that at least some...

  9. Constructing Madness. Discourse analysis of changes in the DSM

    OpenAIRE

    Böröndi, Anita

    2014-01-01

    Understandings of mental disorders have changed over time and related concepts are often contested and definitions. This project used discourse analysis to analyse how the official definition of substance related disorders have changed in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders in comparison with the previous fourth edition (APA, 2000, 2013a). In particular, the analysis focused on how the changes are presented as justified in academic discourse. Three r...

  10. Method in the Madness: Hysteria and the Will to Power

    Directory of Open Access Journals (Sweden)

    Matthew Gildersleeve

    2016-07-01

    Full Text Available At the very start of a chapter on hysteria in her book From Mastery to Analysis: Theories of Gender in Psychoanalytic Feminism, Patricia Elliot cites Nietzsche’s “truths are illusions of which one has forgotten that they are illusions”. This paper follows this connection between hysteria and the work of Nietzsche. This paper will highlight how a Lacanian interpretation of hysteria can elucidate Heidegger’s reading of Nietzsche’s Will to Power and how this interpretation of the Will to Power can better explain the value and importance of hysteria for psychoanalysis and philosophy. I will show that the hysteric’s discourse has a “higher value” than the master’s discourse because it meets Nietzsche’s definition of art, which aims at life’s enhancement rather than the master’s knowledge or truth which aims at the preservation of life. My work will explain how the hysteric’s discourse can transform the master’s discourse into the analyst’s discourse through the Will to Power. This is important, as this is the ultimate aim of psychoanalysis where “At the end of analysis the subject passes to the position of analyst”. This is the ultimate aim of psychoanalysis because “For Lacan, the Discourse of the Analyst is revolutionary because it articulates the truth of the (unconscious subject”. Fundamentally, the objective of this article is to demonstrate that “hysteria is to be understood not as an ‘abnormal’ condition but as one possible manifestation of the subject’s uncanny relationship to itself”.

  11. Eluks ajaks ehitatud kollaažmaja / Madli Maruste

    Index Scriptorium Estoniae

    Maruste, Madli

    2006-01-01

    2006. a. valminud ovaalvormidega betoonist valatud villa Nõmmel. Arhitektuurse lahenduse ja interjööri autorid on omanik Indrek Unt ning Lauri Laisaar ja Gert Sarv. Maja hoovipoolsed küljed on klaasist. Betoonist on valatud paljud mööbliesemed. Metallskulptuuride, metallist kamina, metalltorudest voodite ja diivanite autor on Kalle Pruuden. 2005. a. parim betooneramu. Ill.: I ja II korruse plaan, 11 värv. vaadet

  12. Nycomed SEFA muudab Põlvas ravimi kaubaks / Madli Kents

    Index Scriptorium Estoniae

    Kents, Madli

    2003-01-01

    Põlva ettevõtete 2002. aasta edetabelis teise koha saavutanud ravimitootja Nycomed SEFA tegevjuhi Ants Nurga sõnul jõuti majanduslikult heade tulemusteni tänu müügitöö põhjalikule ümberkorraldamisele. Diagramm: Nycomed Sefa käive ja kasum 1999-2003. Vt. samas: Nycomed parandab Euroopa tervist.

  13. Gustav Naan ja Sigma Tau / Arvo Pesti, Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Arvo, 1956-2010

    2009-01-01

    Füüsik, kosmoloog ja ühiskonnategelane Gustav Naanist. Merle Karusoo dokumentaallavastusest "Sigma Tau-C705", mis põhineb Enn Vetemaa ja Erki Aule näidendil "Gustav Naani hiilgus ja viletsus". Esietendus 16. märtsil 2008 Eesti Draamateatris

  14. Democratic Conscience versus the Madness of Fanatical Terrorism

    DEFF Research Database (Denmark)

    Bouchet, Dominique

    2015-01-01

    Terrorist violence is not religious because it destroys all bonds. Obscurantists who have turned into robots treat others as mere things and seek to spread fear and promote discord and stigmatization in order to generate disorder. The unifying strength of democracy lies in pluralism, diversity, d......, doubt, freedom of speech, education and the fight against all forms of stigmatization. The outrage of the millions who are spontaneously marching in the name of humanity as a whole and not their belonging to a sub-group can bring about a regeneration of democratic ideals....

  15. Lüüriline ingel Baltoscandalil / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2008-01-01

    Rootsi näitleja, laulja, tantsija Charlotte Engelkes, kes Baltoscandalile tuleb oma soololavastuse "Forellen and me" maailmaesietendusega ja 2006. aastal valminud lavastusega "Miss Very Wagner". Lähemalt esimesest lavastusest. Lisaks tutvustus "Esietendused Baltoscandalil"

  16. The Mad Genius Stereotype: Still Alive and Well.

    Science.gov (United States)

    Baudson, Tanja G

    2016-01-01

    Scientists and laypeople agree on high ability as a defining feature of giftedness. Yet their views on gifted people's socioemotional characteristics diverge. Most studies find the gifted to be similar or slightly superior to average-ability persons in these domains ("harmony hypothesis"). However, subjective conceptions and media representations, most of which have focused on gifted children and youth, stress the socioemotional downsides of giftedness ("disharmony hypothesis"), affecting highly able individuals and those around them, thus hampering individual development. To date, most studies on gifted stereotypes have examined selective samples, mostly teachers. The present study is the first to provide representative data on conceptions of gifted individuals in general. A brief survey of 1029 German adults assessed quality and prevalence of stereotypes about gifted individuals, without an explicit focus on children and/or adolescents. Latent class analysis (LCA) revealed two conceptions of giftedness, with twice as many "disharmonious" than "harmonious" raters. Male gender, single parenthood, unemployment, higher income or negative attitudes toward the gifted predicted disharmonious ratings. However, effects were small, suggesting future studies look deeper into the processes of stereotype formation and maintenance.

  17. Managing Madness: Mental Health and Complexity in Public Policy

    Directory of Open Access Journals (Sweden)

    Ian Hickie

    2013-09-01

    Full Text Available This paper explores the concept of collaborative care, particularly in relation to a range of new models of organisation and service that are emerging in response to one of the most problematic areas of public policy – mental health. These emerging models of coordinated mental health care are testing the limits of the evidence supporting coordinated care, and require critical evaluation. Myriad concepts of collaborative or coordinated care in health, including mental health, have created multiple definitions. Once definitional issues have been surmounted, however, the evidence for coordination of health care is reasonably strong. There is considerable research about which treatments and programs are best for people with a mental illness. There are few areas seemingly as complex as mental health, given that responsibility for policy and service lies across all three tiers of Australian government and across multiple jurisdictions. It also engages public, private and non-government sectors. Co-morbidities are commonplace, particularly drug and alcohol problems among younger people. Governments in Australia have traditionally taken responsibility for policy, programs and services, either as direct service providers or through contracting outputs from others. Yet the evidence indicates that for people with a mental illness, the best solutions are often not found in government but in the community and in organisations outside of government. New organisations and new structures are attempting more holistic management approaches, combining clinical care, community support, housing, employment and other services. This paper considers some of these new models in the light of existing evidence. The key challenge facing continued reform in mental health is not uncertainty regarding programs or services, but rather how to drive coordinated care for consumers across departments, governments and providers. This review will highlight the key changes that must be made for the benefit of the millions of Australians with a mental illness. Such changes need to empower users of care systems to choose options that actively support coordinated and efficient care delivery systems.

  18. It's a Mad, Mad Wordle: For a New Take on Text, Try This Fun Word Cloud Generator

    Science.gov (United States)

    Foote, Carolyn

    2009-01-01

    Nation. New. Common. Generation. These are among the most frequently used words spoken by President Barack Obama in his January 2009 inauguration speech as seen in a fascinating visual display called a Wordle. Educators, too, can harness the power of Wordle to enhance learning. Imagine providing students with a whole new perspective on…

  19. Consultation by CSA/France Energie Eolienne of French people living in a municipality at the vicinity of a wind farm. Study report

    International Nuclear Information System (INIS)

    2015-04-01

    This Power Point presentation presents the results of a survey on inhabitants of a municipality located at less than 1.000 meters from a wind farm (the survey was conducted in March 2015 on more than 500 persons and by telephone). Results are presented in terms of feeling, and of available information before the construction, of perceived benefits (mainly ecological rather than economic), of daily impact in terms of noise, of landscape and of image

  20. Directory of the manufacturers and suppliers for the French wind power industry; Annuaire des fabricants et fournisseurs de l'industrie eolienne 2010-2011

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-11-15

    With over 5, 660 MW installed in end-2010, France ranks fourth in Europe, behind Germany, Spain and Italy. The wind power industry currently employs almost 11, 000 people in France throughout the value chain. In 2009, the first edition of this directory listed over one hundred companies working in around twenty different areas. Encouraged by these initial positive results, and with the help of ADEME, the French syndicate for renewable energies (SER) asked Capgemini Consulting to undertake a study to identify and raise awareness among French industrials likely to enter into the wind energy market. The French Ministry for Ecology, Energy, Sustainable Development and the Sea, along with the Ministry for the Economy, Finance and Employment, were involved in the work. 400 companies were questioned as part of the study. Over 150 replies testified to the dynamic character of the wind power market in France and overseas, and the opportunities for diversification that it represents for traditional industries like metallurgy, aeronautics, defence and shipyards, etc. The study led to the creation of the initiative Windustry France, which currently groups over 300 companies either active in the French wind power market or set to enter it. Windustry France is a showcase of the industrial know-how that can be used in the wind power industry both onshore and offshore. It includes local set-ups developed around major fields of activity (e.g. car industry, aeronautics, mechanics, etc.) and industrial port zones (Dunkerque, Rouen/Le Havre, Brest, Nantes Saint-Nazaire, Bordeaux, etc.). Several ministries, regional stakeholders and authorities are also involved (local authorities, Regional directorates for industry, research and the environment (DReal) networks and chambers of commerce and industry), all of which contribute to making Windustry France a collective approach to industrial policy. The 2010-2011 edition of the directory of manufacturers and suppliers for the wind power industry includes 180 actors in the French wind energy industry. Content: 1 - presentation of the French syndicate for renewable energies (SER); 2 - presentation of France Wind energy; 3 - the wind energy value chain; 4 - diagram of the value chain; 5 - list of fields of activity; 6 - regional wind power initiatives; 7 - manufacturers; 8 - suppliers; 9 - Index by field and by region

  1. The wind power state of the art and development outlooks; L'energie eolienne etat de l'art et perspectives de developpement

    Energy Technology Data Exchange (ETDEWEB)

    Bal, J.L. [Agence de l' Environnement et de la Maitrise de l' Energie, ADEME, 75 - Paris (France)

    2005-07-01

    This document presented during the Physics Summer school, deals with the wind power situation in Europe. The wind energy conversion in electric power is explained as the management and implementing of a wind site. The author discusses also the economy of the wind power and the market and development outlooks. (A.L.B.)

  2. Comparative study of energy conversion system dedicated to a small wind turbine; Etude comparative de chaines de conversion d'energie dediees a une eolienne de petite puissance

    Energy Technology Data Exchange (ETDEWEB)

    Mirecki, A

    2005-07-01

    This study presents a comparison of architectures and strategies of energy management dedicated to VAWT turbines such as Savonius. A Maximum Power Point Tracking must be implemented in order to optimize the energetic behavior. A torque or a speed control, or an indirect control of the DC bus current is possible. In the fact that the wind turbine characteristic is unknown, an operational research based on fuzzy logic is proposed. Aiming to minimize the cost of the static conversion structure, simple structures (diode bridge inverter, associated with DC-DC chopper) are analyzed and compared with a system based on a PWM Voltage Source Inverter. A test bench has been realized in the meantime as a system simulation. Comparisons of the provided energy are made for different wind speeds allowing to evaluate the performance of each structure and of the control strategies. (author)

  3. To end with the untruth on the wind energy cost; Pour en finir avec les contre-verites sur le cout de l'energie eolienne

    Energy Technology Data Exchange (ETDEWEB)

    Le Biez, V

    2008-07-01

    In a study published by the Montaigne institute, in July 2008, Vincent Le Biez aimed to criticize the development of the wind energy and more especially its cost. Experts of the SER (Syndicat of the Renewable Energies) and the FEE (France Wind Energy ) answer, in this report, to the criticisms of V. Le Biez. Their analysis shows that the wind energy already constitutes a protection against the increase of the electrical market prices and will offer a real benefit for the collectivity in 2020. The increase of the wind energy in the world shows the trumps of this electricity production form. (A.L.B.)

  4. Wind power installations in Switzerland - Regional planning basics and impact; Eoliennes en Suisse. Bases de planification pour l'amenagement du territoire et effets. Rapport de base

    Energy Technology Data Exchange (ETDEWEB)

    Ott, W.; Kaufmann, Y.; Steiner, P. [Econcept AG, Zuerich (Switzerland); Gilgen, K.; Sartoris, A. [IRAP-HSR, Institut fuer Raumentwicklung an der Hochschule fuer Technik Rapperswil, Rapperswil (Switzerland)

    2008-07-01

    This report published by the Swiss Federal Office of Energy (SFOE) takes a look at the basics of regional planning and its impact on the construction of wind-energy installations in Switzerland. The authors state that the planning and realisation of wind turbine installations is often time and resource consuming: this document presents and discusses the results obtained in a project that aimed to supply consolidated knowledge on project-relevant basics and their effect with respect to wind-energy installations. Experience gained in Switzerland and in other countries is discussed. This report on the basics of wind-energy planning with its detailed information formed the basis of a checklist described in a further report. In nine chapters, regional planning aspects, environment and landscape-relevant aspects, effects on the national and regional economies and social acceptance factors are discussed. Also, success-factors and possible solutions for the successful realisation of wind-energy projects are looked at.

  5. Wind power installations in Switzerland - Checklist for investors in large-scale installations; Eoliennes en Suisse. Liste de controle pour investisseurs de grandes installations

    Energy Technology Data Exchange (ETDEWEB)

    Ott, W.; Kaufmann, Y.; Steiner, P. [Econcept AG, Zuerich (Switzerland); Gilgen, K.; Sartoris, A. [IRAP-HSR, Institut fuer Raumentwicklung an der Hochschule fuer Technik Rapperswil, Rapperswil (Switzerland)

    2008-07-01

    This report published by the Swiss Federal Office of Energy (SFOE) takes a look at a checklist for investors in large-scale wind-power installations. The authors state that the same questions are often posed in the course of the planning and realisation of wind turbine installations. This document presents a checklist that will help achieve the following goals: Tackling the steps involved in the planning and implementation phases, increasing planning security, systematic implementation in order to reduce risks for investors and to shorten time-scales as well as the reduction of costs. Further, participative processes can be optimised by using comprehensively prepared information in order to reduce the risk of objections during project approval. The structure of the check-list is described and discussed.

  6. Wind power installations in Switzerland - Guidelines for the analysis of environmental impact; Eoliennes en Suisse. Guide pour l'analyse des effets sur l'environnement

    Energy Technology Data Exchange (ETDEWEB)

    Ott, W.; Kaufmann, Y.; Steiner, P. [Econcept AG, Zuerich (Switzerland); Gilgen, K.; Sartoris, A. [IRAP-HSR, Institut fuer Raumentwicklung an der Hochschule fuer Technik Rapperswil, Rapperswil (Switzerland)

    2008-07-01

    This report published by the Swiss Federal Office of Energy (SFOE) provides guidelines concerning the impact of the construction of wind-energy installations on the environment in Switzerland. The report aims to ascertain the relevant environmental aspects of the construction of such wind turbines. If no relevant restrictions apply, the acceptance of such wind power installations is said to increase. The guidelines also recommend a standardised course of action and provide sources of information for investors that are necessary for successful planning. The results which can be obtained by using these guidelines can be used to compile a short-form report for cantonal environment protection agencies. An appendix contains an example of the structure of such a report.

  7. Wind energy in France: which perspectives at the year 2010 vista?; Energie Eolienne en France: quelles perspectives a l'horizon 2010?

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    The aim of this 3. national colloquium on wind energy was, first, to analyze the European context of the development of wind energy and to make a status of the first years of the French wind energy program. The aim was also to analyze the regional approach of wind power in the national energy plan with its field problems. The perspectives of offshore wind energy development have been considered too, both in France and in the rest of Europe, and the presentations have stressed on the formidable technical potentialities but also on the legal and administrative constraints of the offshore wind farms exploitation. The colloquium was concluded with visits of wind farms in the Languedoc-Roussillon region (S France). (J.S.) (The activities of this conference are further described in separate records that have been prepared for each day of the conference.)

  8. Wind turbine integration guide : towards a new landscape; Guide d'integration des eoliennes au territoire : vers de nouveaux paysages

    Energy Technology Data Exchange (ETDEWEB)

    Boucher, I.; Blais, P. [Quebec Ministere des Affaires Municipales et des Regions, Quebec, PQ (Canada)

    2007-07-01

    Many areas of Quebec have significant wind potential and the province has power infrastructure that allow easy connection of wind power to the electricity grid. As such, wind energy development is occurring in Quebec as part of its sustainable development strategy. Although wind power is a sustainable option, it should not interfere with the aesthetics of local landscapes. Both regional and local municipalities are faced with the challenge of planning wind farms while protecting the tourism industry and maintaining landscapes of interest, including natural and historic sites. This guide was prepared to support wind energy development in a manner that protects local landscapes. It includes examples where wind turbine arrays have been installed in harmony with the environment. It also described existing tools that enable wind turbine site planning through site characterization. This guide also allows the Ministry of Natural Resources to accompany promoters during project planning and evaluate the impact of a project on the landscape. All proposed projects are subject to conditions imposed by regional municipalities, which have jurisdiction over landscape, noise, public safety, and wildlife. Project proponents must meet both social and environmental criteria to ensure the preservation of the municipal territory and the quality of life. Regulations are in place to ensure economic development occurs in tandem with meeting the energy needs of local and regional communities. 31 refs., 1 tabs., 21 figs.

  9. Shades of green: A bird's eye view of wind energy; L'energie eolienne et son impact sur les oiseaux

    Energy Technology Data Exchange (ETDEWEB)

    Whittam, B.; Kingsley, A.

    2003-03-31

    The issue of birds being killed by wind turbines is discussed. The substance of the argument is that contrary to beliefs held primarily by those opposed to wind turbine developments, when correctly sited, wind turbines appear to have relatively little impact on birds. Historically, 'bird-kill' was a significant factor in the 1980s when a significant number of raptors were killed by wind turbines and their associated power lines in California, Tennessee, Spain and the Netherlands, where many turbines were located on major bird migration routes. Based on experiences learned from these occurrences, several countries have produced bird-focused guidelines for the siting of wind turbines. In Canada, Bird Studies Canada was recently contracted by Environment Canada to produce guidelines for the environmental assessment of wind turbine projects related to birds. The objective of the guidelines is to help prevent adverse impacts on birds, whether the impact is related to habitat disturbance or collision. Based on American studies, it is estimated that 2.19 birds are killed annually at each wind turbine in California; the estimated fatality rate elsewhere in the United States is 1.83. That works out to 33,000 dead birds (based on 15,000 wind turbines), a large number, but relatively small when compared with the millions of birds that travel over windfarms each year, or when compared to the many millions of birds that die annually due to collisions with transmission lines, vehicles, buildings and communication towers. Nevertheless, there is room for concern. Bird Studies Canada is particularly concerned about the growing offshore wind industry and its potential to disrupt songbird migration, waterfowl staging areas and the prey base of seabirds. In general, Bird Studies Canada advises against siting large wind facilities in areas heavily travelled by birds, and is firmly opposed to placing wind turbines in areas known to provide critical habitat for Species At Risk. 13 refs., photos.

  10. The echo of the functioning of wind turbines on the man health; Le retentissement du fonctionnement des eoliennes sur la sante de l'homme

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    The noise is the most frequent complaint, irregular in intensity it perturbs the sleep. Wind turbines are made responsible for other subjective disorders such as:headaches, fatigue, temporary sensations of drunkenness, nausea and sometimes objective ones such as: vomits, insomnias, palpitations. The movements of the shade of pales in rotation were made responsible for absent-mindedness susceptible to bring car accidents, even epilepsy. The most important modification of the environment due to the functioning of wind turbines is as any industrial installation, the creation of vibrations of the ambient environment. A working group asked by the Academy of medicine to examine this question gives some recommendations: to realize a procedure to register on a period of several weeks, the noise induced by wind turbines in houses, to implement an epidemiology inquiry on the sanitary consequences of this noise on the populations, that will be correlated with the distance from these turbines; by waiting the results of these studies, the Academia recommends to suspend the construction of the wind turbines of a power superior to 2.5 MW situated unless 1500 m houses, to modify the article 98 of the law of the 2. july 2003 to consider the wind turbines as industrial facilities when they go over a chosen power and their setting-up are submitted to a regulation taking into account noise pollutions which they induce. (N.C.)

  11. Proceedings of the International Conference on Wind Energy in Remote Regions; Actes du Colloque International sur Energie Eolienne et Site Eloignes

    Energy Technology Data Exchange (ETDEWEB)

    Gipe, P.; Brudny, J.F.; Ilinca, A.; Bouchard, Y.; Proulx, P.; Chaumel, J.L.; Brunelle, M.T.; Henin, S.; Beaudoin, P.; Poirier, N.; Belanger, M. [Quebec Univ., Rimouski, PQ (Canada). WERR Organizational Committee

    2005-07-01

    This international conference focused on the growth opportunities for the wind power industry in Canada, with particular focus on Quebec and eastern Canada. The conference presented formal paper sessions dealing with the largest wind turbine technology to the smallest machines. It also included tutorials, site visits, case studies and commercial exhibits aimed at wind power developers, utility managers, manufacturers, sub-contractors, theoreticians and practitioners. Participants discussed the best and innovative solutions for the efficient regional development of wind power with particular focus on remote, off-grid applications such as isolated northern communities and islands. The presentations emphasized how wind energy can allow isolated communities to reduce their dependence on costly imported diesel fuel by combining modern electronics with wind turbines and diesel power systems. Environmental impacts and future innovations in wind technology were also discussed along with practical solutions for combining wind energy with other sources of energy. The conference featured 30 presentations, of which 18 have been catalogued separately for inclusion in this database. refs., tabs., figs.

  12. Conditions of call for tenders on the offshore wind power plants; Conditions de l'appel d'offres portant sur des centrales eolienne en mer

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    In the framework of the renewable energies sources development, the french government decided to launch a call for tenders for the realization of offshore wind power plants in 2007. The call for tenders conditions concern: the energetic and technical characteristics of the installations as the primary energy, the production technic, the power; the industrial implementing delay; the exploitation and the operating time; the implementing sites; the weighting and the classification principles. The main conditions concerning the utilization of the maritime public land property outside of the harbors. (A.L.B.)

  13. A concepção de loucura e do seu tratamento entre os trabalhadores de saúde mental de uma instituição prestadora de serviço em nível secundário de atenção La concepción de locura y de su tratamiento, en los trabajadores de salud mental de una institución The conception of madness and its treatment to mental health workers from a second level service institution

    Directory of Open Access Journals (Sweden)

    Valéria Mastrange Pugin

    1997-05-01

    Full Text Available O presente trabalho tem como objetivo analisar as concepções de loucura e do seu tratamento entre os trabalhadores de saúde mental de uma instituição prestadora de serviço em nível secundário de atenção e a visão destes sobre o tratamento oferecido pela instituição. A pesquisa empírica foi realizada através de entrevistas semi-estruturadas com trabalhadores da equipe de saúde mental. Através da análise dos discursos foram observadas diversas formas de conceber a loucura sendo divididas em dois grupos: um que reproduz o saber científico (ligadas as diversas correntes de pensamento da área e outro que reproduz o saber advindo da prática. Este último apresenta uma visão social da loucura uma vez que ela é vista como produto das desigualdades sociais. Encontramos também a visão de periculosidade do doente mental em três categorias entrevistadas.El presente trabajo tuvo por objetivo analizar las concepciones de la locura y su tratamiento, considerando los trabajadores de la salud mental que se desempeñan en una institución prestadora de servicios a nivel secundario, y la visión de éstos sobre el tratamiento que les es dado por la propia institución. La investigación empírica fue realizada a través de entrevistas semi-estructuradas, con los discursos fueron observadas diversas formas de concebir la locura, fueron divididas en dos grupos: uno que reproduce el saber científico (vinculado a las diversas corrientes de pensamiento en el área y otro que reproduce el saber oriundo de la práctica. Este último presenta una visión social de la locura, dado que ésta es un producto de las desigualdades sociales. Encontramos también la visión de la peligrosidad del enfermo mental, en tres categorías entrevistadas.This paper aims at analyzing madness, as considered by mental health care workers from a second level service institution, and how they see the therapy offered by the organization. A research was conducted

  14. Cracks on instrumentation penetrations in reactor vessel: a new challenge; Fissuration des penetrations de cuve: un nouveau defi

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2004-02-01

    In august 2003 NRC (nuclear regulatory commission) issued a warning concerning the deposits of boron acid that might accumulate on instrumental penetrations in the bottom of PWR vessels. These deposits were first detected on the David-Besse power plant and more recently on the unit 1 of South Texas Project (STP) during a refueling shutdown. STP contracted with the Areva company in order to perform inspections on all the 58 vessel penetrations of the unit 1 and to propose solutions. For that purpose the Areva company had to design a specific visual inspection tool that combined both ultra-sound method and Foucault current probing. The results of the inspection campaign on the unit 1 showed that only 2 penetration tubes were concerned with axial defects in their walls, that no circumferential defects were detected and that butt welds presented no cracks. The 2 incriminated penetration tubes were repaired: a section of both was replaced by an alloy-690 tube. (A.C.)

  15. Un nouveau réseau sans fil pour les travailleurs de la santé | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    10 nov. 2010 ... ... médecine de l'Université de Makerere, procèdent à un essai-pilote d'un système sans fil qui utilise des ordinateurs de poche et des ordinateurs Linux alimentés par des batteries. Le programme Connectivité Afrique du Centre de recherches pour le développement international (CRDI) appuie cette étude.

  16. La boîte de Pandore : un nouveau modèle pour l'éducation en Asie ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    31 janv. 2011 ... La formation à distance qui s'appuie sur les TIC pourrait cependant changer la donne. « L'apprentissage à distance est une réalité qui ne date pas d'hier », de dire Malik. « Toutefois, l'irruption des technologies de l'information et de la communication dans le processus de formation a permis de hausser la ...

  17. New economical concept of maritime terminal for LNG; Nouveau concept de terminal maritime a cout reduit pour le GNL

    Energy Technology Data Exchange (ETDEWEB)

    Dupont, B. [EURODIM S.A. (France)

    2000-07-01

    This series of slides present a new concept of marine terminal for LNG tanker-ships that requires less investments and offers a better adaptability to loading/unloading sites with a bad accessibility. This concept uses flexible cryogenic flow-lines developed by Coflexip Stena Offshore, double-envelope submarine pipes with a reinforced thermal insulation and the multi-purpose cryogenic connection module developed by Eurodim S.A. (J.S.)

  18. Au-delà de la justice pénale - vers un nouveau paradigme pour les ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    En d'autres termes, il s'agit de comprendre comment ces cycles de violence sont liés à ... Beyond Nuremberg : learning from the post-apartheid transition in South Africa ... IDRC and the National Research Foundation (NRF) of South Africa are ...

  19. ImpersoNations: cinéma national, imaginaires historiques et nouveau cinéma européen

    NARCIS (Netherlands)

    Elsaesser, T.

    2013-01-01

    La question du capital culturel propre à la diversité linguistique de l’Europe reste entière. Quels sont les avantages et les inconvénients de cet éventail de langues dans le cinéma? Les films, quand ils franchissent les frontières, sont souvent doublés. Or, comme un bon jeu d’acteur représente une

  20. Nouveau découpage de la zone de forêt dense humide de la Côte d ...

    African Journals Online (AJOL)

    humide climatique répondant aux définitions physionomiques de Yangambi .... ascendante, qui est un outil d'exploration de données pour ...... Guillaumet J.-L., 1967. Recherches sur la végétation et la flore de la région du Bas-. Cavally (Côte d'Ivoire). O.R.S.T.O.M., Paris. 247 pp. Guillaumet J.-L., 1979. Végétation. A6a. In :.