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Sample records for mact standard guidance

  1. A practical approach to meeting MACT standards with process evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Sudnick, J.J. [ECKENFELDER Inc., Greenville, SC (United States)

    1996-12-31

    Maximum achievable control technology (MACT) standards for hazardous air pollutants can be met in a variety of ways. These range from process change and modification to installation of control equipment. Many times a combination of the two results in the best solution. A case study is used to illustrate an optimization approach to identifying the best method of control; in addition, the approach increased the efficiency and profitability of the process. Starting with the process itself, analyzing its operation, and developing options presented the total picture - controlling emissions and improving the product. Participation of plant personnel in the evaluation, selection, and design provided for an optimal design with buy in from the people who operate it on a daily basis. 3 figs., 5 tabs.

  2. Are you really subject to MACT?

    Energy Technology Data Exchange (ETDEWEB)

    Hawkins, S.C. [Eckenfelder Inc., Greenville, SC (United States)

    1997-02-01

    Three techniques are highlighted to minimize the regulatory burden of the Maximum Achievable Control Technology (MACT) standards for major sources of hazardous air pollutants as set forth in the 1990 Clean Air Act.

  3. WERF MACT Feasibility Study Report

    Energy Technology Data Exchange (ETDEWEB)

    B. Bonnema; D. Moser; J. Riedesel; K. Kooda; K. Liekhus; K. Rebish; S. Poling

    1998-11-01

    This study was undertaken to determine the technical feasibility of upgrading the Waste Experimental Reduction Facility (WERF) at the Idaho National Engineering and Environmental Laboratory to meet the offgas emission limits proposed in the Maximum Achievable Control Technologies (MACT)rule. Four practicable offgas treatment processes were identified, which, if installed, would enable the WERF to meet the anticipated MACT emission limits for dioxins and furans (D/F), hydrochloric acid (HCI), and mercury (Hg). Due to the three-year time restraint for MACT compliance, any technology chosen for the upgrade must be performed within the general plant project funding limit of $5 M. The option selected consists of a partial-quench evaporative cooler with dry sorbent injection for HCI removal followed by a sulfur-impregnated activated carbon bed for Hg control. The planning cost estimate for implementing the option is $4.17 M (with 24% contingency). The total estimated cost includes capital costs, design and construction costs, and project management costs. Capital costs include the purchase of a new offgas evaporative cooler, a dry sorbent injection system with reagent storage, a new fabric filter baghouse, a fixed carbon bed absorber, and two offgas induced draft exhaust fans. It is estimated that 21 months will be required to complete the recommended modification to the WERF. The partial-quench cooler is designed to rapidly cool the offgas exiting the secondary combustion chamber to minimize D/F formation. Dry sorbent injection of an alkali reagent into the offgas is recommended. The alkali reacts with the HCI to form a salt, which is captured with the fly ash in the baghouse. A design HCI removal efficiency of 97.2% allows for the feeding 20 lbs/hr of chlorine to the WERF incinerator. The sorbent feed rate can be adjusted to achieve the desired HCI removal efficiency. A fixed bed of sulfur-impregnated carbon was conservatively sized for a total Hg removal capacity when

  4. High Temperature Calcination - MACT Upgrade Equipment Pilot Plant Test

    Energy Technology Data Exchange (ETDEWEB)

    Richard D. Boardman; B. H. O& #39; Brien; N. R. Soelberg; S. O. Bates; R. A. Wood; C. St. Michel

    2004-02-01

    About one million gallons of acidic, hazardous, and radioactive sodium-bearing waste are stored in stainless steel tanks at the Idaho Nuclear Technology and Engineering Center (INTEC), which is a major operating facility of the Idaho National Engineering and Environmental Laboratory. Calcination at high-temperature conditions (600 C, with alumina nitrate and calcium nitrate chemical addition to the feed) is one of four options currently being considered by the Department of Energy for treatment of the remaining tank wastes. If calcination is selected for future processing of the sodium-bearing waste, it will be necessary to install new off-gas control equipment in the New Waste Calcining Facility (NWCF) to comply with the Maximum Achievable Control Technology (MACT) standards for hazardous waste combustors and incinerators. This will require, as a minimum, installing a carbon bed to reduce mercury emissions from their current level of up to 7,500 to <45 {micro}g/dscm, and a staged combustor to reduce unburned kerosene fuel in the off-gas discharge to <100 ppm CO and <10 ppm hydrocarbons. The staged combustor will also reduce NOx concentrations of about 35,000 ppm by 90-95%. A pilot-plant calcination test was completed in a newly constructed 15-cm diameter calciner vessel. The pilot-plant facility was equipped with a prototype MACT off-gas control system, including a highly efficient cyclone separator and off-gas quench/venturi scrubber for particulate removal, a staged combustor for unburned hydrocarbon and NOx destruction, and a packed activated carbon bed for mercury removal and residual chloride capture. Pilot-plant testing was performed during a 50-hour system operability test January 14-16, followed by a 100-hour high-temperature calcination pilot-plant calcination run January 19-23. Two flowsheet blends were tested: a 50-hour test with an aluminum-to-alkali metal molar ratio (AAR) of 2.25, and a 50-hour test with an AAR of 1.75. Results of the testing

  5. National Emission Standards for Hazardous Air Pollutants for Major Sources. Industrial, Commercial, and Institutional Boilers; Guidance for Calculating Emission Credits Resulting from Implementation of Energy Conservation Measures

    Energy Technology Data Exchange (ETDEWEB)

    Papar, Riyaz [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wright, Anthony [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Cox, Daryl [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2012-07-01

    The purpose of this document is to provide guidance for developing a consistent approach to documenting efficiency credits generated from energy conservation measures in the Implementation Plan for boilers covered by the Boiler MACT rule (i.e., Subpart DDDDD of CFR Part 63).

  6. Codes and standards and other guidance cited in regulatory documents

    Energy Technology Data Exchange (ETDEWEB)

    Nickolaus, J.R.; Bohlander, K.L.

    1996-08-01

    As part of the U.S. Nuclear Regulatory Commission (NRC) Standard Review Plan Update and Development Program (SRP-UDP), Pacific Northwest National Laboratory developed a listing of industry consensus codes and standards and other government and industry guidance referred to in regulatory documents. The SRP-UDP has been completed and the SRP-Maintenance Program (SRP-MP) is now maintaining this listing. Besides updating previous information, Revision 3 adds approximately 80 citations. This listing identifies the version of the code or standard cited in the regulatory document, the regulatory document, and the current version of the code or standard. It also provides a summary characterization of the nature of the citation. This listing was developed from electronic searches of the Code of Federal Regulations and the NRC`s Bulletins, Information Notices, Circulars, Enforcement Manual, Generic Letters, Inspection Manual, Policy Statements, Regulatory Guides, Standard Technical Specifications and the Standard Review Plan (NUREG-0800).

  7. HFE Process Guidance and Standards for potential application to updating NRC guidance

    Energy Technology Data Exchange (ETDEWEB)

    Jacques Hugo; J. J. Persensky

    2012-07-01

    The U.S. Nuclear Regulatory Commission (NRC) reviews and evaluates the human factors engineering (HFE) programs of applicants for nuclear power plant construction permits, operating licenses, standard design certifications, and combined operating licenses. The purpose of these safety reviews is to help ensure that personnel performance and reliability are appropriately supported. Detailed design review procedures and guidance for the evaluations is provided in three key documents: the Standard Review Plan (NUREG-0800), the HFE Program Review Model (NUREG-0711), and the Human-System Interface Design Review Guidelines (NUREG-0700). These documents were last revised in 2007, 2004 and 2002, respectively. The NRC is committed to the periodic update and improvement of these guidance documents to ensure that they remain state-of-the-art design evaluation tools. Thus, the NRC has initiated a project with BNL to update the NRC guidance to remain current with recent research on human performance, advances in HFE methods and tools, and new technology. INL supported Brookhaven National Lab (BNL) to update the detailed HFE review criteria contained in NUREG-0711 and NUREG-0700 based on (1) feedback obtained from end users, (2) the results of NRC research and development efforts supporting the NRC staff’s HFE safety reviews, and (3) other material the project staff identify as applicable to the update effort. INL submitted comments on development plans and sections of NUREGs 0800, 0711, and 0700. The contractor prepared the report attached here as the deliverable for this work.

  8. Comparison of ISO 9000 and recent software life cycle standards to nuclear regulatory review guidance

    Energy Technology Data Exchange (ETDEWEB)

    Preckshot, G.G.; Scott, J.A.

    1998-01-20

    Lawrence Livermore National Laboratory is assisting the Nuclear Regulatory Commission with the assessment of certain quality and software life cycle standards to determine whether additional guidance for the U.S. nuclear regulatory context should be derived from the standards. This report describes the nature of the standards and compares the guidance of the standards to that of the recently updated Standard Review Plan.

  9. National Emission Standards for Hazardous Air Pollutants for Major Sources: Industrial, Commercial, and Institutional Boilers; Guidance for Calculating Emission Credits Resulting from Implementation of Energy Conservation Measures

    Energy Technology Data Exchange (ETDEWEB)

    Cox, Daryl [ORNL; Papar, Riyaz [Hudson Technologies; Wright, Dr. Anthony [ALW Consulting

    2012-07-01

    The purpose of this document is to provide guidance for developing a consistent approach to documenting efficiency credits generated from energy conservation measures in the Implementation Plan for boilers covered by the Boiler MACT rule (i.e., subpart DDDDD of CFR part 63). This document divides Boiler System conservation opportunities into four functional areas: 1) the boiler itself, 2) the condensate recovery system, 3) the distribution system, and 4) the end uses of the steam. This document provides technical information for documenting emissions credits proposed in the Implementation Plan for functional areas 2) though 4). This document does not include efficiency improvements related to the Boiler tune-ups.

  10. National Emission Standards for Hazardous Air Pollutants for Major Sources: Industrial, Commercial, and Institutional Boilers; Guidance for Calculating Efficiency Credits Resulting from Implementation of Energy Conservation Measures

    Energy Technology Data Exchange (ETDEWEB)

    Cox, Daryl [ORNL; Papar, Riyaz [Hudson Technologies; Wright, Dr. Anthony [ALW Consulting

    2013-02-01

    The purpose of this document is to provide guidance for developing a consistent approach to documenting efficiency credits generated from energy conservation measures in the Implementation Plan for boilers covered by the Boiler MACT rule (i.e., subpart DDDDD of CFR part 63). This document divides Boiler System conservation opportunities into four functional areas: 1) the boiler itself, 2) the condensate recovery system, 3) the distribution system, and 4) the end uses of the steam. This document provides technical information for documenting emissions credits proposed in the Implementation Plan for functional areas 2) though 4). This document does not include efficiency improvements related to the Boiler tune-ups.

  11. 75 FR 70011 - Guidance for Industry, Mammography Quality Standards Act Inspectors, and Food and Drug...

    Science.gov (United States)

    2010-11-16

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry, Mammography Quality Standards Act Inspectors, and Food and Drug Administration Staff; The Mammography Quality Standards Act Final Regulations: Modifications and Additions to Policy Guidance Help System 13; Availability AGENCY: Food and Drug...

  12. 75 FR 15440 - Guidance for Industry on Standards for Securing the Drug Supply Chain-Standardized Numerical...

    Science.gov (United States)

    2010-03-29

    ... Supply Chain--Standardized Numerical Identification for Prescription Drug Packages; Availability AGENCY... to the Division of Docket Management (HFA-305), Food and Drug Administration, 5630 Fishers Lane, rm... availability of a guidance for industry entitled ``Standards for Securing the Drug Supply...

  13. DOD Information Technology Standard Guidance (ITSG) Version 3.1

    Science.gov (United States)

    1997-04-07

    data and metadata and can be applied to them. d. NIST FIPS 183: IDEFO e. NIST FIPS 184: IDEFIX f. Data element standards in the datz dictionary BSA...183: IDEFO e. NIST FIPS 184: IDEFIX f. Data element standards in the data dictionary BSA, above. 3.9.3.3.6 Recommendations. IRDS, FIPS 156, is

  14. Building America Guidance for Identifying and Overcoming Code, Standard, and Rating Method Barriers

    Energy Technology Data Exchange (ETDEWEB)

    Cole, P. C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Halverson, M. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2013-09-01

    This guidance document was prepared using the input from the meeting summarized in the draft CSI Roadmap to provide Building America research teams and partners with specific information and approaches to identifying and overcoming potential barriers to Building America innovations arising in and/or stemming from codes, standards, and rating methods.

  15. 12 CFR Appendix C to Part 1720 - Policy Guidance; Safety and Soundness Standards for Information

    Science.gov (United States)

    2010-01-01

    ..., App. C Appendix C to Part 1720—Policy Guidance; Safety and Soundness Standards for Information A..., technical, or physical safeguards used by an Enterprise to access, collect, process, store, use, transmit..., collect, store, use, transmit, protect, or dispose of information; d. Service provider means any person or...

  16. Codes and standards and other guidance cited in regulatory documents. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Ankrum, A.; Nickolaus, J.; Vinther, R.; Maguire-Moffitt, N.; Hammer, J.; Sherfey, L.; Warner, R. [Pacific Northwest Lab., Richland, WA (United States)

    1994-08-01

    As part of the US Nuclear Regulatory Commission (NRC) Standard Review Plan Update and Development Program, Pacific Northwest Laboratory developed a listing of industry consensus codes and standards and other government and industry guidance referred to in regulatory documents. In addition to updating previous information, Revision 1 adds citations from the NRC Inspection Manual and the Improved Standard Technical Specifications. This listing identifies the version of the code or standard cited in the regulatory document, the regulatory document, and the current version of the code or standard. It also provides a summary characterization of the nature of the citation. This listing was developed from electronic searches of the Code of Federal Regulations and the NRC`s Bulletins, Information Notices, Circulars, Generic Letters, Policy Statements, Regulatory Guides, and the Standard Review Plan (NUREG-0800).

  17. An efficient auto TPT stitch guidance generation for optimized standard cell design

    Science.gov (United States)

    Samboju, Nagaraj C.; Choi, Soo-Han; Arikati, Srini; Cilingir, Erdem

    2015-03-01

    As the technology continues to shrink below 14nm, triple patterning lithography (TPT) is a worthwhile lithography methodology for printing dense layers such as Metal1. However, this increases the complexity of standard cell design, as it is very difficult to develop a TPT compliant layout without compromising on the area. Hence, this emphasizes the importance to have an accurate stitch generation methodology to meet the standard cell area requirement as defined by the technology shrink factor. In this paper, we present an efficient auto TPT stitch guidance generation technique for optimized standard cell design. The basic idea here is to first identify the conflicting polygons based on the Fix Guidance [1] solution developed by Synopsys. Fix Guidance is a reduced sub-graph containing minimum set of edges along with the connecting polygons; by eliminating these edges in a design 3-color conflicts can be resolved. Once the conflicting polygons are identified using this method, they are categorized into four types [2] - (Type 1 to 4). The categorization is based on number of interactions a polygon has with the coloring links and the triangle loops of fix guidance. For each type a certain criteria for keep-out region is defined, based on which the final stitch guidance locations are generated. This technique provides various possible stitch locations to the user and helps the user to select the best stitch location considering both design flexibility (max. pin access/small area) and process-preferences. Based on this technique, a standard cell library for place and route (P and R) can be developed with colorless data and a stitch marker defined by designer using our proposed method. After P and R, the full chip (block) would contain the colorless data and standard cell stitch markers only. These stitch markers are considered as "must be stitch" candidates. Hence during full chip decomposition it is not required to generate and select the stitch markers again for the

  18. Business combinations under common control in International Financial Reporting Standards – is authoritative accounting guidance needed?

    Directory of Open Access Journals (Sweden)

    Magdalena Janowicz

    2017-09-01

    Full Text Available Business combinations under common control in International Financial Reporting Standards – is authoritative accounting guidance needed? The purpose of the article is to answer the question if a separate standard (IFRS is needed for business combinations under common control (BCUCC, which are not governed by any IFRS as the moment. In such cases, the approach resulting from IAS 8 should apply to them, which allows the use of national regulations to account for BCUCC. The authoress shortly described the theoretical issues related to the subject and presented the results of empirical research that verified the practical aspects of the problem. The research methodology involves a literature and legal act analysis, content analysis of financial statements, as well as deductive and inductive reasoning. On the basis of the gathered data the authoress concluded that even the existence of necessary regulations in national GAAPs does not guarantee that all the requirements related to the qualitative characteristics of the reported information are met and, as such, the main objectives for which IFRS were developed may not be met. As such, the authoritative guidance proves necessary. Very little research on the subject was published, thus, this paper may provide some additional guidance as to what issues related to BCUCC should receive particular attention.

  19. Building America Guidance for Identifying and Overcoming Code, Standard, and Rating Method Barriers

    Energy Technology Data Exchange (ETDEWEB)

    Cole, Pamala C.; Halverson, Mark A.

    2013-09-01

    The U.S. Department of Energy’s (DOE) Building America program implemented a new Codes and Standards Innovation (CSI) Team in 2013. The Team’s mission is to assist Building America (BA) research teams and partners in identifying and resolving conflicts between Building America innovations and the various codes and standards that govern the construction of residences. A CSI Roadmap was completed in September, 2013. This guidance document was prepared using the information in the CSI Roadmap to provide BA research teams and partners with specific information and approaches to identifying and overcoming potential barriers to Building America (BA) innovations arising in and/or stemming from codes, standards, and rating methods. For more information on the BA CSI team, please email: CSITeam@pnnl.gov

  20. 40 CFR 63.55 - Maximum achievable control technology (MACT) determinations for affected sources subject to case...

    Science.gov (United States)

    2010-07-01

    ... limitations. 63.55 Section 63.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR..., Sections 112(g) and 112(j) § 63.55 Maximum achievable control technology (MACT) determinations for affected...

  1. Jimmo and the improvement standard: implementing Medicare coverage through regulations, policy manuals and other guidance.

    Science.gov (United States)

    Gladieux, Jennifer E; Basile, Michael

    2014-01-01

    In Jimmo v. Sebelius, the plaintiffs alleged that the Centers for Medicare and Medicaid Services (CMS) regularly and improperly denied Medicare reimbursement for outpatient therapy treatment when the beneficiary did not show a likelihood of improvement. These denials, based on policy manuals and other guidance, appear to contradict the government's own regulations, which specifically prohibit coverage denials based solely on the so-called "Improvement Standard." In Jimmo, the United States District Court for the District of Vermont found that CMS' use of the Improvement Standard may have violated the rulemaking provisions of the Administrative Procedure Act (APA) and denied CMS' motion for summary judgment. Subsequently, the parties settled out of court. In the settlement, CMS agreed to revise its policy manuals to clarify that the Improvement Standard was not an acceptable basis on which to deny Medicare coverage. CMS declined to defend its policies even though courts often grant deference to agency interpretations. The settlement implies that the agency feared that it would not have received such deference. It also implies that future Supreme Court decisions may give less deference to agency interpretations.

  2. National Guidance on Interpretation of the New Source Performance Standards - Subpart Y (Standards of Performance for Coal Preparation Plants)

    Science.gov (United States)

    This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  3. Short communication: retinoic acid plus prolactin to synergistically increase specific casein gene expression in MAC-T cells.

    Science.gov (United States)

    Lee, H Y; Heo, Y T; Lee, S E; Hwang, K C; Lee, H G; Choi, S H; Kim, N H

    2013-06-01

    Mammary alveolar (MAC-T) cells, an established bovine mammary epithelial cell line, are frequently used to investigate differentiation. A lactogenic phenotype in these cells is induced by treatment with a combination of hydrocortisone, insulin, and prolactin (PRL). The effect of the vitamin A derivative retinoic acid (RA), which induces differentiation in many cells, has not been studied in MAC-T cells. The objective of this study was to evaluate the differentiation potential of RA (1 μM) in MAC-T cells and to examine the effect of combined treatment with RA (1 μM) and PRL (5 μg/mL). Although RA treatment alone inhibited MAC-T cell proliferation, co-treatment of RA with PRL increased cell growth compared with the control group (treated with 1 μg/mL hydrocortisone and 5 μg/mL insulin). The ratio of Bcl to Bax mRNA was decreased in the RA treatment compared with RA+PRL or control. Retinoic acid-induced differentiation of MAC-T cells was associated with an increase in the mRNA expression of αS1-casein (3.9-fold), αS2-casein (4.5-fold), and β-casein (4.4-fold) compared with the control group. Expression of αS1-casein, αS2-casein, and β-casein was increased 12.9-fold, 11.9-fold, and 19.3-fold, respectively, following treatment with RA and PRL combined compared with the control group. These results demonstrate that RA induces differentiation of MAC-T cells and acts synergistically with PRL to increase specific casein gene expression.

  4. 36 CFR 1235.3 - What standards are used as guidance for this part?

    Science.gov (United States)

    2010-07-01

    ... RECORDS ADMINISTRATION RECORDS MANAGEMENT TRANSFER OF RECORDS TO THE NATIONAL ARCHIVES OF THE UNITED... regulations conform to guidance provided in ISO 15489-1:2001. Paragraphs 8.3 (Designing and implementing records systems), 9.6 (Storage and handling), and 9.7 (Access) are particularly relevant to this part....

  5. 36 CFR 1230.2 - What standards are used as guidance for this part?

    Science.gov (United States)

    2010-07-01

    ... RECORDS ADMINISTRATION RECORDS MANAGEMENT UNLAWFUL OR ACCIDENTAL REMOVAL, DEFACING, ALTERATION, OR... with guidance provided in ISO 15489-1:2001, par. 6.3 (Responsibilities), 7.2 (Characteristics of a record), 8.2 (Records systems characteristics), and 8.3 (Designing and implementing records systems)....

  6. Preparation of radiological effluent technical specifications for nuclear power plants. a guidance manual for users of standard technical specifications

    Energy Technology Data Exchange (ETDEWEB)

    Boegli, J.S.; Bellamy, R.R.; Britz, W.L.; Waterfield, R.L. (eds.)

    1978-10-01

    The purpose of this manual is to describe methods found acceptable to the staff of the U.S. Nuclear Regulatory Commission (NRC) for the calculation of certain key values required in the preparation of proposed radiological effluent Technical Specifications using the Standard Technical Specifications for light-water-cooled nuclear power plants. This manual also provides guidance to applicants for operating licenses for nuclear power plants in the preparation of proposed radiological effluent Technical Specifications or in preparing requests for changes to existing radiological effluent Technical Specifications for operating licenses. The manual additionally describes current staff positions on the methodology for estimating radiation exposure due to the release of radioactive materials in effluents and on the administrative control of radioactive waste treatment systems.

  7. Comparison of MACT and 5Fu+ACT-D chemotherapy regimens in the treatment of low-risk gestational trophoblastic neoplasia.

    Science.gov (United States)

    Wang, Yu; Miao, Jin-Wei; Wang, Tong; Wang, Yan; Wu, Yu-Mei; Kong, Wei-Min; Su, Li; Duan, Wei

    2016-04-01

    The study aimed to compare the efficacy of methotrexate (MTX) cervical injections + actinomycin-D (ACT-D)(MACT) and 5-fluorouracil (5-Fu) + actinomycin-D (5-Fu plus ACT-D) chemotherapy regimens for low-risk gestational trophoblastic neoplasia (LR-GTN). Clinical data from 66 LR-GTN patients, admitted to the Beijing Obstetrics and Gynecology Hospital from January 2010 to April 2012, were analysed retrospectively. In total, 32 patients were treated with a MACT therapeutic regimen and the remaining 34 with a 5Fu + ACT-D therapeutic regimen. Complete remission rates (CR), duration of treatment, hospital stay and toxicity effects were compared. There was no statistical difference in CR for the MACT (90.63%) or the 5-Fu plus ACT-D (100%) therapeutic regimens (p = 0.0676) or in the duration of treatment [MACT (3.50) or 5-Fu plus ACT-D (3.71; p = 0.2021)]. Moreover, the hospital stay in the 5-Fu plus ACT-D group (32.88 days) was significantly longer than for the MACT group (22.09 days; p < 0.001). Furthermore, the degree of myelosuppression, nausea and vomiting, diarrhoea, stomatitis and alopecia was more severe in the 5Fu + ACT-D group (p < 0.01). However, there was no statistical difference in the severity of liver function damage between the two groups. A shorter hospital stay, lower hospitalization cost and slightly more toxic effects were observed in LR-GTN patients treated with the MACT therapeutic regimen. We suggest that the MACT regimen should be used as first-line chemotherapy for LR-GTN.

  8. Geospatial resources for supporting data standards, guidance and best practice in health informatics

    Directory of Open Access Journals (Sweden)

    Kamel Boulos Maged N

    2011-01-01

    Full Text Available Abstract Background The 1980s marked the occasion when Geographical Information System (GIS technology was broadly introduced into the geo-spatial community through the establishment of a strong GIS industry. This technology quickly disseminated across many countries, and has now become established as an important research, planning and commercial tool for a wider community that includes organisations in the public and private health sectors. The broad acceptance of GIS technology and the nature of its functionality have meant that numerous datasets have been created over the past three decades. Most of these datasets have been created independently, and without any structured documentation systems in place. However, search and retrieval systems can only work if there is a mechanism for datasets existence to be discovered and this is where proper metadata creation and management can greatly help. This situation must be addressed through support mechanisms such as Web-based portal technologies, metadata editor tools, automation, metadata standards and guidelines and collaborative efforts with relevant individuals and organisations. Engagement with data developers or administrators should also include a strategy of identifying the benefits associated with metadata creation and publication. Findings The establishment of numerous Spatial Data Infrastructures (SDIs, and other Internet resources, is a testament to the recognition of the importance of supporting good data management and sharing practices across the geographic information community. These resources extend to health informatics in support of research, public services and teaching and learning. This paper identifies many of these resources available to the UK academic health informatics community. It also reveals the reluctance of many spatial data creators across the wider UK academic community to use these resources to create and publish metadata, or deposit their data in repositories

  9. 76 FR 17159 - Office of New Reactors; Final Interim Staff Guidance on Standard Review Plan, Section 17.4...

    Science.gov (United States)

    2011-03-28

    .... SUMMARY: The NRC staff is issuing its Final Interim Staff Guidance (ISG) DC/COL-ISG-018 (Agencywide... of ] the design certification (DC) and combined license (COL) applications. The NRC staff issues DC/COL-ISGs to facilitate timely implementation of current staff guidance and to facilitate...

  10. NF-κB is involved in the LPS-mediated proliferation and apoptosis of MAC-T epithelial cells as part of the subacute ruminal acidosis response in cows.

    Science.gov (United States)

    Fan, Wen-Jie; Li, He-Ping; Zhu, He-Shui; Sui, Shi-Ping; Chen, Pei-Ge; Deng, Yue; Sui, Tong-Ming; Wang, Yue-Ying

    2016-11-01

    To determine the effect of NF-κB on cell proliferation and apoptosis, we investigate the expression of inflammation and apoptosis-related factors in the bovine mammary epithelial cell line, MAC-T. MAC-T cells were cultured in vitro and MTT and LDH assays used to determine the effects of lipopolysaccharide (LPS) on proliferation and cytotoxicity respectively. RT-PCR and western blotting were used to evaluate the effect of LPS and NF-κB inhibition [pyrrolidine dithiocarbamate (PDTC) treatment] on the expression of inflammation and apoptosis-related factors. LPS significantly inhibited MAC-T cell proliferation in a dose- and time-dependent manner. Furthermore, LPS promoted apoptosis while the NF-кB inhibitor PDTC attenuated this effect. After LPS treatment, the NF-кB signaling pathway was activated, and the expression of inflammation and apoptosis-related factors increased. When PDTC blocked NF-кB signaling, the expression of inflammation and apoptosis-related factors were decreased in MAC-T cells. LPS activates the TLR4/NF-κB signaling pathway, inhibits proliferation and promotes apoptosis in MAC-T cells. NF-кB inhibition attenuates MAC-T cell apoptosis and TLR4/NF-κB signaling pathway. NF-кB inhibitor alleviating MAC-T cell apoptosis is presumably modulated by NF-кB.

  11. 77 FR 43405 - Final Standard Review Plan, Branch Technical Position 7-19 on Guidance for Evaluation of...

    Science.gov (United States)

    2012-07-24

    ... and Defense-in-Depth in Digital Computer-Based Instrumentation and Control Systems AGENCY: Nuclear... ``Guidance for Evaluation of Diversity and Defense-in-Depth in Digital Computer-Based Instrumentation and Control Systems.'' This BTP is to be cited as the acceptance criteria for Diversity and...

  12. 75 FR 14643 - Office of New Reactors; Proposed Standard Review Plan, Branch Technical Position 7-19 on Guidance...

    Science.gov (United States)

    2010-03-26

    ... for Evaluation of Diversity and Defense-in-Depth in Digital Computer-Based Instrumentation and Control... Guidance for Evaluation of Diversity and Defense-in-Depth in Digital Computer-Based Instrumentation and...). This BTP is to be cited as the acceptance criteria for Diversity and Defense-in-Depth (D3) in...

  13. DOE Handbook: Supplementary guidance and design experience for the fusion safety standards DOE-STD-6002-96 and DOE-STD-6003-96

    Energy Technology Data Exchange (ETDEWEB)

    None

    1999-01-01

    Two standards have been developed that pertain to the safety of fusion facilities. These are DOE- STD-6002-96, Safety of Magnetic Fusion Facilities: Requirements, and DOE-STD-6003-96, Safety of Magnetic Fusion Facilities: Guidance. The first of these standards identifies requirements that subscribers to that standard must meet to achieve safety in fusion facilities. The second standard contains guidance to assist in meeting the requirements identified in the first This handbook provides additional documentation on good operations and design practices as well as lessons learned from the experiences of designers and operators of previous fusion facilities and related systems. It is intended to capture the experience gained in the various fields and pass it on to designers of future fusion facilities as a means of enhancing success and safety. The sections of this document are presented according to the physical location of the major systems of a fusion facility, beginning with the vacuum vessel and proceeding to those systems and components outside the vacuum vessel (the "Ex-vessel Systems"). The last section describes administrative procedures that cannot be localized to specific components. It has been tacitly assumed that the general structure of the fusion facilities addressed is that of a tokamak though the same principles would apply to other magnetic confinement options.

  14. 75 FR 9647 - National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion...

    Science.gov (United States)

    2010-03-03

    ...), EPA proposed performance specification requirements for continuous parametric monitoring systems (CPMS... questioned the emission standard setting approach that EPA used at proposal and claimed that the proposed... data in the MACT floor analysis. EPA is also using an approach that better considers emissions...

  15. Model Child Care Standards Act--Guidance to States to Prevent Child Abuse in Day Care Facilities.

    Science.gov (United States)

    Department of Health and Human Services, Washington, DC.

    The document offers guidelines to states regarding review and revision of child care statutes, standards, and policies to address the prevention of child sexual abuse in day care facilities. General information is also provided on changes in state standards in recent years. Each of six sections examines findings of the 1981 Comparative Licensing…

  16. Anticipatory guidance through DVD.

    Science.gov (United States)

    Franz, Sandra; McMahon, Pamela M; Calongne, Laurinda; Steele-Moses, Susan K

    2014-03-01

    The major purpose of the study was to determine if a 5-minute DVD is an effective method for communicating anticipatory guidance to parents at their child's 4-month well-child visit. A total of 84 caregivers were randomly assigned to receive anticipatory guidance through standard care (written anticipatory guidance handout and free talk) or DVD (DVD format + standard care). Participants completed a brief questionnaire immediately before and after their visit. As anticipated, knowledge scores improved significantly from pre-test to post-test. There was also a significant interaction between format used for anticipatory guidance and time. Specifically, there was greater improvement in knowledge over time for parents in the DVD group as compared with the standard care group. Additionally, the mean knowledge level of those in the DVD group as compared with those in the standard care group trended toward significance. Finally, visit length was shortened by nearly 3 minutes in the DVD group, and close to 100% of all respondents, regardless of anticipatory guidance format, indicated that they were very satisfied with their visit and amount of information learned.

  17. Lifelong Guidance

    National Research Council Canada - National Science Library

    Noworol, Czesław

    2011-01-01

    .... Career guidance refers to services and activities intended to assist individuals, of any age and at any point throughout their lives, to make educational, training and occupational choices and to manage their careers...

  18. 3D-isotropic high-resolution morphological imaging and quantitative T2 mapping as biomarkers for gender related differences after matrix-associated autologous chondrocyte transplantation (MACT).

    Science.gov (United States)

    Pachowsky, Milena L; Werner, Sven; Marlovits, Stefan; Stelzeneder, David; Renner, Nina; Trattnig, Siegfried; Welsch, Goetz H

    2014-10-01

    The aim of this study was to determine in vivo high-resolution morphological and biochemical gender related differences in cartilage repair tissue (MACT). Forty patients were examined clinically and by MR scans at 3T-MRI (coronal 3D True-FISP sequence for morphologic assessment and multi-echo spin-echo T2-mapping for biochemical assessment of healthy cartilage and MACT cartilage). Mean T2 values in repair tissue in the deep zone showed significantly shorter T2 times in females (p = 0.009, female 43.5 ± 9.8 vs. male 48.2 ± 7.7 ms). The superficial zone showed higher T2 values than the deep zone in both the groups (female 48.5 ± 9.8, males 52.6 ± 11.0 ms) without significant difference between female and male patients. Native control cartilage showed no statistically significant differences for T2 between females and males. The subdivisions "structure of the repair tissue" and "subchondral bone" of the MOCART score showed statistically significant differences between females and males (p = 0.026 and p = 0.007) as well as the Lysholm score (p = 0.03). Our investigations revealed differences between female and male patients after MACT of the knee in clinical outcome and advanced morphological and biochemical MRI. The presented imaging biomarkers can depict subtle changes after cartilage regeneration procedures and might help to understand gender related differences after cartilage repair procedures. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  19. Evaluation of information in nanomaterial safety data sheets and development of international standard for guidance on preparation of nanomaterial safety data sheets.

    Science.gov (United States)

    Lee, Ji Hyun; Kuk, Won Kwen; Kwon, Miran; Lee, Jong Han; Lee, Kwon Sub; Yu, Il Je

    2013-05-01

    Safety data sheets (SDSs) and labelling are the basic hazard communication tools for hazardous chemicals as regards their manufacture, storage, transport and other handling activities. Thus, in the context of the growing use of nanomaterials and nanomaterial-containing materials, this study evaluated the information provided in 97 nanomaterial-related SDSs according to the criteria set by the GHS (Globally Harmonized System of Classification and Labelling of Chemicals) and found that most of the SDSs did not include sufficient information on the safety of nanomaterials, such as their toxicity and physicochemical properties. The reasons for this lack of information in the nanomaterial SDSs can mainly be attributed to (1) a lack of toxicity and physicochemical property information on nanomaterials, (2) unawareness of the effectiveness of conventional exposure controls, such as local exhaust ventilation and encapsulation, and personal protective equipment (PPE), in protecting against nanomaterial exposure, (3) a lack of information on emergency and firefighting measures and (4) a lack of knowledge on how existing regulations apply to nanomaterials. Therefore, to create a consistent standard for the information provided on safety, health and environmental matters for manufactured nanomaterial-containing products, guidance for the preparation of nanomaterial-specific SDSs, including both nanomaterials and mixtures of nanomaterials with conventional non-nanoscale materials, was recently initiated by the ISO TC 229. Their guidance, in the form of a technical report, recommends that nanomaterial-related SDSs should be prepared based on a precautionary approach in terms of the toxicity and other risks associated with the nanomaterial contents within the mixture in question. One of the key recommendations in the technical report is to include additional physicochemical properties, including the particle size (average and range), size distribution aggregation

  20. Quality Assurance in University Guidance Services

    Science.gov (United States)

    Simon, Alexandra

    2014-01-01

    In Europe there is no common quality assurance framework for the delivery of guidance in higher education. Using a case study approach in four university career guidance services in England, France and Spain, this article aims to study how quality is implemented in university career guidance services in terms of strategy, standards and models,…

  1. Quality Assurance in University Guidance Services

    Science.gov (United States)

    Simon, Alexandra

    2014-01-01

    In Europe there is no common quality assurance framework for the delivery of guidance in higher education. Using a case study approach in four university career guidance services in England, France and Spain, this article aims to study how quality is implemented in university career guidance services in terms of strategy, standards and models,…

  2. Information architecture. Volume 3: Guidance

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    The purpose of this document, as presented in Volume 1, The Foundations, is to assist the Department of Energy (DOE) in developing and promulgating information architecture guidance. This guidance is aimed at increasing the development of information architecture as a Departmentwide management best practice. This document describes departmental information architecture principles and minimum design characteristics for systems and infrastructures within the DOE Information Architecture Conceptual Model, and establishes a Departmentwide standards-based architecture program. The publication of this document fulfills the commitment to address guiding principles, promote standard architectural practices, and provide technical guidance. This document guides the transition from the baseline or defacto Departmental architecture through approved information management program plans and budgets to the future vision architecture. This document also represents another major step toward establishing a well-organized, logical foundation for the DOE information architecture.

  3. Antibacterial Activity of 7-Epiclusianone and Its Novel Copper Metal Complex on Streptococcus spp. Isolated from Bovine Mastitis and Their Cytotoxicity in MAC-T Cells.

    Science.gov (United States)

    de Barros, Mariana; Perciano, Pedro Griffo; Dos Santos, Marcelo Henrique; De Oliveira, Leandro Licursi; Costa, Éderson D'Martin; Moreira, Maria Aparecida Scatamburlo

    2017-05-17

    Mastitis is an inflammation of mammary gland parenchyma that adversely affects bovine health and dairy production worldwide despite significant efforts to eradicate it. The aim of this work was to characterize the antimicrobial activity of 7-epiclusianone (7-epi), a compound extracted from the Rheedia brasiliensis fruit, its complex with copper against Streptococcus spp. isolated from bovine mastitis, and to assess their cytotoxicity to bovine mammary alveolar cells (MAC-T). The complex 7-epiclusianone-Cu (7-epi-Cu) was an amorphous green solid with optical activity. Its vibrational spectrum in the infrared region showed absorption bands in the high-frequency region, as well as bands that can be attributed to the unconjugated and conjugated stretching of the free ligand. The complex was anhydrous. One of the tested bacterial strains was not sensitive to the compounds, while the other three had MIC values of 7.8 µg mL(-1) and minimum bactericidal concentration (MBC) values between 15.6 and 31.3 µg mL(-1). These two compounds are bacteriostatic, did not cause damage to the cell wall and, at sub-inhibitory concentrations, did not induce bacterial adhesion. The compounds were not cytotoxic. Based on these results, 7-epi and 7-epi-Cu exhibited desirable antimicrobial properties and could potentially be used in bovine mastitis treatment.

  4. Review of soil contamination guidance

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, M.A.; Kennedy, W.E. Jr.; Soldat, J.K.

    1981-08-01

    A review of existing and proposed radioactive soil contamination standards and guidance was conducted for United Nuclear Corporation (UNC), Office of Surplus Facilities Management. Information was obtained from both government agencies and other sources during a literature survey. The more applicable standards were reviewed, evaluated, and summarized. Information pertaining to soil contamination for both facility operation and facility decommissioning was obtained from a variety of sources. These sources included: the Code of Federal Regulations, regulatory guides, the Federal Register, topical reports written by various government agencies, topical reports written by national laboratories, and publications from the American National Standards Institute (ANSI). It was difficult to directly compare the standards and guidance obtained from these sources since each was intended for a specific situation and different units or bases were used. However, most of the information reviewed was consistent with the philosophy of maintaining exposures at levels as low as reasonably achievable (ALARA).

  5. The Entropy Module and Bispectral Index as guidance for propofol-remifentanil anaesthesia in combination with regional anaesthesia compared with a standard clinical practice group.

    NARCIS (Netherlands)

    Ellerkmann, R.K.; Soehle, M.; Riese, G.; Zinserling, J.; Wirz, S.; Hoeft, A.; Bruhn, J.

    2010-01-01

    This study was designed to investigate the impact of the Entropy Module and Bispectral Index (BIS) monitoring on drug consumption and recovery times compared with standard anaesthetic practice in patients undergoing orthopaedic surgery using a combination of regional and general anaesthesia as perfo

  6. The Entropy Module and Bispectral Index as guidance for propofol-remifentanil anaesthesia in combination with regional anaesthesia compared with a standard clinical practice group.

    NARCIS (Netherlands)

    Ellerkmann, R.K.; Soehle, M.; Riese, G.; Zinserling, J.; Wirz, S.; Hoeft, A.; Bruhn, J.

    2010-01-01

    This study was designed to investigate the impact of the Entropy Module and Bispectral Index (BIS) monitoring on drug consumption and recovery times compared with standard anaesthetic practice in patients undergoing orthopaedic surgery using a combination of regional and general anaesthesia as perfo

  7. Costing the distribution of insecticide-treated nets: a review of cost and cost-effectiveness studies to provide guidance on standardization of costing methodology

    Directory of Open Access Journals (Sweden)

    Hanson Kara

    2006-05-01

    Full Text Available Abstract Background Insecticide-treated nets (ITNs are an effective and cost-effective means of malaria control. Scaling-up coverage of ITNs is challenging. It requires substantial resources and there are a number of strategies to choose from. Information on the cost of different strategies is still scarce. To guide the choice of a delivery strategy (or combination of strategies, reliable and standardized cost information for the different options is required. Methods The electronic online database PubMed was used for a systematic search of the published English literature on costing and economic evaluations of ITN distribution programmes. The keywords used were: net, bednet, insecticide, treated, ITN, cost, effectiveness, economic and evaluation. Identified papers were analysed to determine and evaluate the costing methods used. Methods were judged against existing standards of cost analysis to arrive at proposed standards for undertaking and presenting cost analyses. Results Cost estimates were often not readily comparable or could not be adjusted to a different context. This resulted from the wide range of methods applied and measures of output chosen. Most common shortcomings were the omission of certain costs and failure to adjust financial costs to generate economic costs. Generalisability was hampered by authors not reporting quantities and prices of resources separately and not examining the sensitivity of their results to variations in underlying assumptions. Conclusion The observed shortcomings have arisen despite the abundance of literature and guidelines on costing of health care interventions. This paper provides ITN specific recommendations in the hope that these will help to standardize future cost estimates.

  8. On guidance and volatility

    NARCIS (Netherlands)

    Billings, M.B.; Jennings, R.; Lev, B.

    2013-01-01

    Survey evidence suggests that managers voluntarily disclose information, particularly earnings guidance, with an aim toward dampening share price volatility. Yet, consultants and influential institutions advise against providing guidance — citing fears of litigation and market penalties associated w

  9. Graphic Turbulence Guidance

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Forecast turbulence hazards identified by the Graphical Turbulence Guidance algorithm. The Graphical Turbulence Guidance product depicts mid-level and upper-level...

  10. Graphical Turbulence Guidance - Composite

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Forecast turbulence hazards identified by the Graphical Turbulence Guidance algorithm. The Graphical Turbulence Guidance product depicts mid-level and upper-level...

  11. 10 CFR 430.4 - Sources for information and guidance.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Sources for information and guidance. 430.4 Section 430.4... Provisions § 430.4 Sources for information and guidance. (a) General. The standards listed in this paragraph... reference. These sources are given here for information and guidance. (b) IESNA. Illuminating Engineering...

  12. Optimal ratios of essential amino acids stimulate β-casein synthesis via activation of the mammalian target of rapamycin signaling pathway in MAC-T cells and bovine mammary tissue explants.

    Science.gov (United States)

    Li, S S; Loor, J J; Liu, H Y; Liu, L; Hosseini, A; Zhao, W S; Liu, J X

    2017-08-01

    Amino acids are the building blocks of proteins and serve as key molecular components upstream of the signaling pathways that regulate protein synthesis. The objective of this study was to systematically investigate the effect of essential AA ratios on milk protein synthesis in vitro and to elucidate some of the underlying mechanisms. Triplicate cultures of MAC-T cells and bovine mammary tissue explants (MTE) were incubated with the optimal AA ratio (OPAA; Lys:Met, 2.9:1; Thr:Phe, 1.05:1; Lys:Thr, 1.8:1; Lys:His, 2.38:1; and Lys:Val, 1.23:1) in the presence of rapamycin (control), OPAA, a Lys:Thr ratio of 2.1:1, a Lys:Thr ratio of 1.3:1, a Lys:His ratio of 3.05:1, or a Lys:Val ratio of 1.62:1 for 12 h; the other AA concentrations were equal to OPAA. In some experiments, the cells were cultured with OPAA with or without rapamycin (100 ng/mL) or with mammalian target of rapamycin (mTOR) small interference RNA, and the MTE were exposed to OPAA with rapamycin for β-casein expression. Among the treatments, the expression of β-casein was greatest in the MTE cultured with OPAA. In MAC-T cells, the OPAA upregulated the mRNA expression of SLC1A5 and SLC7A5 but downregulated the expression of IRS1, AKT3, EEF1A1, and EEF2 compared with the control. The OPAA had no effect on the mTOR phosphorylation status but increased the phosphorylation of S6K1 and RPS6. When the MTE were treated with rapamycin in the presence of OPAA, the expression of β-casein was markedly decreased. The phosphorylation of RPS6 and 4EBP1 also was reduced in MAC-T cells. A similar negative effect on the expression of RPS6KB1 and EIF4EBP1 was detected when the cells were cultured with either rapamycin or mTOR small interference RNA. The optimal AA ratio stimulated β-casein expression partly by enhancing the transport of AA into the cells, cross-talk with insulin signaling and a subsequent enhancement of mTOR signaling, or translation elongation in both MAC-T cells and bovine MTE. Copyright © 2017

  13. Current materiality guidance for auditors

    OpenAIRE

    McKee, Thomas E.; Eilifsen, Aasmund

    2000-01-01

    Auditors have to make materiality judgments on every audit. This is a difficult process, as both quantitative and qualitative factors have to be evaluated. Additionally, there is no formal guidance for how to implement the materiality concepts discussed in the auditing standards. Although they are sometimes difficult to make, good materiality judgments are crucial for the conduct of a successful audit as poor judgments can result in an audit that is ineffective and/or inefficient. This report...

  14. Guidance for performing preliminary assessments under CERCLA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-09-01

    EPA headquarters and a national site assessment workgroup produced this guidance for Regional, State, and contractor staff who manage or perform preliminary assessments (PAs). EPA has focused this guidance on the types of sites and site conditions most commonly encountered. The PA approach described in this guidance is generally applicable to a wide variety of sites. However, because of the variability among sites, the amount of information available, and the level of investigative effort required, it is not possible to provide guidance that is equally applicable to all sites. PA investigators should recognize this and be aware that variation from this guidance may be necessary for some sites, particularly for PAs performed at Federal facilities, PAs conducted under EPA`s Environmental Priorities Initiative (EPI), and PAs at sites that have previously been extensively investigated by EPA or others. The purpose of this guidance is to provide instructions for conducting a PA and reporting results. This guidance discusses the information required to evaluate a site and how to obtain it, how to score a site, and reporting requirements. This document also provides guidelines and instruction on PA evaluation, scoring, and the use of standard PA scoresheets. The overall goal of this guidance is to assist PA investigators in conducting high-quality assessments that result in correct site screening or further action recommendations on a nationally consistent basis.

  15. Career guidance in communities

    DEFF Research Database (Denmark)

    Thomsen, Rie

    The aim of this paper is to inspire practitioners and professionals to leave their offices to bring career guidance into communities that might not identify with career guidance in the first instance. By making the effort to engage with communities, practitioners may bring about a critical change...

  16. Corporate information management guidance

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-08-01

    At the request of the Department of Energy`s (DOE) Information Management (IM) Council, IM representatives from nearly all Headquarters (HQ) organizations have been meeting over the past year as the Corporate Guidance Group (CGG) to develop useful and sound corporate information management (IM) guidance. The ability of the Department`s IM community to develop such unified guidance continues to be critical to the success of future Departmental IM planning processes and the establishment of a well-coordinated IM environment between Headquarters and field organizations. This report, with 26 specific corporate IM guidance items documented and unanimously agreed to, as well as 12 items recommended for further development and 3 items deferred for future consideration, represents a highly successful effort by the IM community. The effort has proven that the diverse DOE organizations can put aside individual preferences and work together towards a common and mutually beneficial goal. In examining most areas and issues associated with information management in the Department, they have developed specific, far-reaching, and useful guidance. The IM representatives recommend that the documented guidance items provided in this report and approved by the DOE IM Council be followed by all IM organizations. The representatives also strongly recommend that the guidance process developed by the CGG be the single process for developing corporate IM guidance.

  17. Shuttle entry guidance

    Science.gov (United States)

    Harpold, J. C.; Graves, C. A., Jr.

    1978-01-01

    This paper describes the design of the entry guidance for the Space Shuttle Orbiter. This guidance provides the steering commands for trajectory control from initial penetration of the earth's atmosphere until the terminal area guidance is activated at an earth-relative speed of 2500 fps. At this point, the Orbiter is at a distance of about 50 nmi from the runway threshold, and at an altitude of about 80,000 ft. The entry guidance design is based on an analytic solution of the equations of motion defining the drag acceleration profile that meets the terminal criteria of the entry flight while maintaining the flight within systems and operational constraints. Guidance commands, which are based on a control law that ensures damping of oscillatory type trajectory motion, are computed to steer the Orbiter to this drag acceleration profile.

  18. Shuttle entry guidance revisited

    Science.gov (United States)

    Mease, Kenneth D.; Kremer, Jean-Paul

    1992-08-01

    The Shuttle entry guidance concept is reviewed which is aimed at tracking a reference drag trajectory that leads to the specified range and velocity for the initiation of the terminal energy management phase. An approximate method of constructing the domain of attraction is proposed, and its validity is ascertained by simulation. An alternative guidance law yielding global exponential tracking in the absence of control saturation is derived using a feedback linearization method. It is noted that the alternative guidance law does not improve on the stability and performance of the current guidance law, for the operating domain and control capability of the Shuttle. It is suggested that the new guidance law with a larger operating domain and increased lift-to-drag capability would be superior.

  19. Shuttle entry guidance revisited

    Science.gov (United States)

    Mease, Kenneth D.; Kremer, Jean-Paul

    1992-01-01

    The Shuttle entry guidance concept is reviewed which is aimed at tracking a reference drag trajectory that leads to the specified range and velocity for the initiation of the terminal energy management phase. An approximate method of constructing the domain of attraction is proposed, and its validity is ascertained by simulation. An alternative guidance law yielding global exponential tracking in the absence of control saturation is derived using a feedback linearization method. It is noted that the alternative guidance law does not improve on the stability and performance of the current guidance law, for the operating domain and control capability of the Shuttle. It is suggested that the new guidance law with a larger operating domain and increased lift-to-drag capability would be superior.

  20. RH Packaging Program Guidance

    Energy Technology Data Exchange (ETDEWEB)

    Washington TRU Solutions LLC

    2008-01-12

    conspicuous location where the activities subject to these regulations are conducted. This document details the instructions to be followed to operate, maintain, and test the RH-TRU 72-B packaging. This Program Guidance standardizes instructions for all users. Users shall follow these instructions or equivalent approved instructions. Following these instructions assures that operations meet the requirements of the SARP.

  1. RH Packaging Program Guidance

    Energy Technology Data Exchange (ETDEWEB)

    Washington TRU Solutions LLC

    2006-11-07

    these regulations are conducted. This document details the instructions to be followed to operate, maintain, and test the RH-TRU 72-B packaging. This Program Guidance standardizes instructions for all users. Users shall follow these instructions or equivalent approved instructions. Following these instructions assures that operations meet the requirements of the SARP.

  2. Water Quality Standards Handbook

    Science.gov (United States)

    The Water Quality Standards Handbook is a compilation of the EPA's water quality standards (WQS) program guidance including recommendations for states, authorized tribes, and territories in reviewing, revising, and implementing WQS.

  3. Laser Guidance Analysis Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This facility, which provides for real time, closed loop evaluation of semi-active laser guidance hardware, has and continues to be instrumental in the development...

  4. My view on occupation guidance

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Occupation instruction needs to the support of theories,in the case of the occupation guidance theory is not very developed in our country,It has very important sense that absorbing and drawing lessons from the advanced occupation guidance theory,and targeting guidance to occupation guidance work,.

  5. RH Packaging Program Guidance

    Energy Technology Data Exchange (ETDEWEB)

    Washington TRU Solutions, LLC

    2003-08-25

    The purpose of this program guidance document is to provide technical requirements for use, operation, inspection, and maintenance of the RH-TRU 72-B Waste Shipping Package and directly related components. This document complies with the requirements as specified in the RH-TRU 72-B Safety Analysis Report for Packaging (SARP), and Nuclear Regulatory Commission (NRC) Certificate of Compliance (C of C) 9212. If there is a conflict between this document and the SARP and/or C of C, the SARP and/or C of C shall govern. The C of C states: ''...each package must be prepared for shipment and operated in accordance with the procedures described in Chapter 7.0, ''Operating Procedures,'' of the application.'' It further states: ''...each package must be tested and maintained in accordance with the procedures described in Chapter 8.0, ''Acceptance Tests and Maintenance Program of the Application.'' Chapter 9.0 of the SARP tasks the Waste Isolation Pilot Plant (WIPP) Management and Operating (M&O) contractor with assuring the packaging is used in accordance with the requirements of the C of C. Because the packaging is NRC approved, users need to be familiar with 10 CFR {section} 71.11, ''Deliberate Misconduct.'' Any time a user suspects or has indications that the conditions of approval in the C of C were not met, the Carlsbad Field Office (CBFO) shall be notified immediately. CBFO will evaluate the issue and notify the NRC if required. This document details the instructions to be followed to operate, maintain, and test the RH-TRU 72-B packaging. This Program Guidance standardizes instructions for all users. Users shall follow these instructions. Following these instructions assures that operations are safe and meet the requirements of the SARP. This document is available on the Internet at: ttp://www.ws/library/t2omi/t2omi.htm. Users are responsible for ensuring they are using the current

  6. Research Requirements for Future Visual Guidance Systems

    Science.gov (United States)

    1994-02-01

    20591. 5. FAA Advisory Circular 150/5340-18, Standards for Airport Sign Systems, latest edition, Washington, DC 20591. 6. Bonaventura , Vincent...Dunlap and Associates, March 1952, New York. 8. Bonaventura , Vincent E., A Proposed Method of Color Coding Airport Taxi Guidance-Sins, The Port of New

  7. Designing Schoolwide Programs. Non-Regulatory Guidance

    Science.gov (United States)

    US Department of Education, 2006

    2006-01-01

    This guidance offers a renewed vision for the use of the schoolwide program, both as a reform strategy and as a means of realizing the high standards for student achievement envisioned by the No Child Left Behind Act of 2001 (NCLB). It is intended to be used as a companion document to the statute and regulations, as well as a technical assistance…

  8. Safety of magnetic fusion facilities: Guidance

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-05-01

    This document provides guidance for the implementation of the requirements identified in DOE-STD-6002-96, Safety of Magnetic Fusion Facilities: Requirements. This guidance is intended for the managers, designers, operators, and other personnel with safety responsibilities for facilities designated as magnetic fusion facilities. While the requirements in DOE-STD-6002-96 are generally applicable to a wide range of fusion facilities, this Standard, DOE-STD-6003-96, is concerned mainly with the implementation of those requirements in large facilities such as the International Thermonuclear Experimental Reactor (ITER). Using a risk-based prioritization, the concepts presented here may also be applied to other magnetic fusion facilities. This Standard is oriented toward regulation in the Department of Energy (DOE) environment as opposed to regulation by other regulatory agencies. As the need for guidance involving other types of fusion facilities or other regulatory environments emerges, additional guidance volumes should be prepared. The concepts, processes, and recommendations set forth here are for guidance only. They will contribute to safety at magnetic fusion facilities.

  9. Vocational Guidance for Everyone

    Science.gov (United States)

    Holland, John L.

    1974-01-01

    Describes some of the current problems of vocational guidance, summarizes relevant knowledge and theory in the field, and offers some practical plans for a coordinated, theoretically compatible group of vocational programs, services, and experiences for a high school. (Author/JM)

  10. PIV Logon Configuration Guidance

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Glen Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-03-04

    This document details the configurations and enhancements implemented to support the usage of federal Personal Identity Verification (PIV) Card for logon on unclassified networks. The guidance is a reference implementation of the configurations and enhancements deployed at the Los Alamos National Laboratory (LANL) by Network and Infrastructure Engineering – Core Services (NIE-CS).

  11. Regulatory guidance document

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-05-01

    The Office of Civilian Radioactive Waste Management (OCRWM) Program Management System Manual requires preparation of the OCRWM Regulatory Guidance Document (RGD) that addresses licensing, environmental compliance, and safety and health compliance. The document provides: regulatory compliance policy; guidance to OCRWM organizational elements to ensure a consistent approach when complying with regulatory requirements; strategies to achieve policy objectives; organizational responsibilities for regulatory compliance; guidance with regard to Program compliance oversight; and guidance on the contents of a project-level Regulatory Compliance Plan. The scope of the RGD includes site suitability evaluation, licensing, environmental compliance, and safety and health compliance, in accordance with the direction provided by Section 4.6.3 of the PMS Manual. Site suitability evaluation and regulatory compliance during site characterization are significant activities, particularly with regard to the YW MSA. OCRWM`s evaluation of whether the Yucca Mountain site is suitable for repository development must precede its submittal of a license application to the Nuclear Regulatory Commission (NRC). Accordingly, site suitability evaluation is discussed in Chapter 4, and the general statements of policy regarding site suitability evaluation are discussed in Section 2.1. Although much of the data and analyses may initially be similar, the licensing process is discussed separately in Chapter 5. Environmental compliance is discussed in Chapter 6. Safety and Health compliance is discussed in Chapter 7.

  12. Career guidance on the move

    DEFF Research Database (Denmark)

    Thomsen, Rie

    2013-01-01

    This article is about how the notion of place can be used in an analysis of career guidance practices and their development. It is about how a focus on the context of career guidance can develop an awareness of the place where guidance is practiced and support the development of career guidance...... in new places. In this article I introduce an analytical perspective on place; I give the example of the guidance café a practice development that took place into serious consideration because it was an attempt to develop career guidance practice through relocating it....

  13. Islamic Guidance for Drug Addiction

    Directory of Open Access Journals (Sweden)

    Agus Supriyanto

    2016-10-01

    Full Text Available Islamic Guidance is social rehabilitation program for Drug Addiction (resident. The goal of this research to know the Islamic guidance for resident at the Center for Rehabilitation of the National Narcotics Agency Lido Bogor. The methodology in this research is qualitative descriptive, with a sample two religious counselor. Can be concluded that Islamic guidance is implemented with the classical format, group format, and individual formats. The goal of the Islamic Guidance to develop religious mentally.

  14. Islamic Guidance for Drug Addiction

    OpenAIRE

    Agus Supriyanto

    2016-01-01

    Islamic Guidance is social rehabilitation program for Drug Addiction (resident). The goal of this research to know the Islamic guidance for resident at the Center for Rehabilitation of the National Narcotics Agency Lido Bogor. The methodology in this research is qualitative descriptive, with a sample two religious counselor. Can be concluded that Islamic guidance is implemented with the classical format, group format, and individual formats. The goal of the Islamic Guidance to develop religio...

  15. PROFESSIONAL GUIDANCE: EXPERIENCE REPORT

    Directory of Open Access Journals (Sweden)

    Fabiana Pinto de Almeida Bizarria

    2014-05-01

    Full Text Available This article presents an account of a career guidance with a group of five teenagers ( 16 and 19 , students of pre-university preparatory course offered by a public university in the state of Ceará . The work group dynamics was from a privileged form of performance by allowing a greater enrichment of the discussions , considering the heterogeneity and diversity of the group . To address relevant issues in career guidance based on the theory Socio-Historical , a roadmap of action process was constructed from three axes . Each axis has worked in two sessions that match a date. The first axis called " meaning of choice," worked on thematic choice process . With regard to the axis " World of Work " was discussed idealizations and representations about the professions , the labor market and the vestibular / ESMS . Emotional links with the professions , skills and ideas on skills and information professions : Finally , the " self " axis, which contains the themes was developed .

  16. PSD Increment Consumption Guidance

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  17. Guidance of Nonlinear Systems

    Science.gov (United States)

    Meyer, George

    1997-01-01

    The paper describes a method for guiding a dynamic system through a given set of points. The paradigm is a fully automatic aircraft subject to air traffic control (ATC). The ATC provides a sequence of way points through which the aircraft trajectory must pass. The way points typically specify time, position, and velocity. The guidance problem is to synthesize a system state trajectory which satisfies both the ATC and aircraft constraints. Complications arise because the controlled process is multi-dimensional, multi-axis, nonlinear, highly coupled, and the state space is not flat. In addition, there is a multitude of possible operating modes, which may number in the hundreds. Each such mode defines a distinct state space model of the process by specifying the state space coordinatization, the partition of the controls into active controls and configuration controls, and the output map. Furthermore, mode transitions must be smooth. The guidance algorithm is based on the inversion of the pure feedback approximations, which is followed by iterative corrections for the effects of zero dynamics. The paper describes the structure and modules of the algorithm, and the performance is illustrated by several example aircraft maneuvers.

  18. Third-party biller compliance guidance emphasizes risk awareness.

    Science.gov (United States)

    Saner, R J

    1999-03-01

    The voluntary compliance guidance for third-party billing companies released by the HHS Office of Inspector General (OIG) in December 1998, like the OIG's previously released guidance directed at hospitals, home health agencies, and clinical laboratories, identifies seven minimum elements for an effective corporate compliance program: written compliance policies, designation of a compliance officer, ongoing training, open lines of communication, guidelines to ensure the enforcement of compliance standards, internal monitoring and auditing of compliance activity, and procedures to respond to and correct errors. Three areas of concern for third-party billing companies are emphasized in the new guidance document: compliance risk, claims documentation, and disclosure of suspected misconduct or fraud.

  19. Blind guidance system based on laser triangulation

    Science.gov (United States)

    Wu, Jih-Huah; Wang, Jinner-Der; Fang, Wei; Lee, Yun-Parn; Shan, Yi-Chia; Kao, Hai-Ko; Ma, Shih-Hsin; Jiang, Joe-Air

    2012-05-01

    We propose a new guidance system for the blind. An optical triangulation method is used in the system. The main components of the proposed system comprise of a notebook computer, a camera, and two laser modules. The track image of the light beam on the ground or on the object is captured by the camera and then the image is sent to the notebook computer for further processing and analysis. Using a developed signal-processing algorithm, our system can determine the object width and the distance between the object and the blind person through the calculation of the light line positions on the image. A series of feasibility tests of the developed blind guidance system were conducted. The experimental results show that the distance between the test object and the blind can be measured with a standard deviation of less than 8.5% within the range of 40 and 130 cm, while the test object width can be measured with a standard deviation of less than 4.5% within the range of 40 and 130 cm. The application potential of the designed system to the blind guidance can be expected.

  20. School Guidance and Counseling in Kenya: Historical Development, Current Status, and Future Prospects

    Science.gov (United States)

    Wambu, Grace W.; Fisher, Teresa A.

    2015-01-01

    Despite the government's emphasis on guidance and counseling program implementation in Kenyan schools and a rapid increase in the number of trained school counselors, lack of standardized training curriculums, ethical standards, counseling models, and role ambiguity persist. This article reviews the historical development of guidance and…

  1. International Conference on Harmonisation; guidance on good manufacturing practice for active pharmaceutical ingredients; availability. Notice.

    Science.gov (United States)

    2001-09-25

    The Food and Drug Administration (FDA) is announcing the availability of a guidance entitled "Q7A Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients." The guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The guidance describes current good manufacturing practice (CGMP) for manufacturing of active pharmaceutical ingredients (APIs). The guidance is intended to help ensure that all APIs meet the standards for quality and purity they purport or are represented to possess.

  2. International Conference on Harmonisation; guidance on Q10 Pharmaceutical Quality System; availability. Notice.

    Science.gov (United States)

    2009-04-08

    The Food and Drug Administration (FDA) is announcing the availability of a guidance entitled "Q10 Pharmaceutical Quality System." The guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The guidance describes a model for an effective quality management system for the pharmaceutical industry, referred to as the Pharmaceutical Quality System. The guidance is intended to provide a comprehensive approach to an effective pharmaceutical quality system that is based on International Organization for Standardization (ISO) concepts, includes applicable good manufacturing practice (GMP) regulations and complements ICH guidances on "Q8 Pharmaceutical Development" and "Q9 Quality Risk Management."

  3. Guidance at the educational marketplace

    DEFF Research Database (Denmark)

    Lystbæk, Christian Tang

    in educational policies and institutions. As educational systems have expanded and, further, have been restructured with the expansion of choice opportunities since the 1980s, guidance has become prioritized as a form of counseling or coaching, which can support students. Thus, guidance has become an important...

  4. Guidance in the Secondary School

    Science.gov (United States)

    Kumar, V. Jurist Lional

    2010-01-01

    Secondary School Students face a lot of problems in their body as well as in mind due to puberty that tends to adolescence stage. Adolescence has peculiar characters of their own. They need proper Guidance and Counselling to tackle their own problems. Guidance is described as a counselling service to assist the individual in achieving self…

  5. Innovative Approaches to Career Guidance.

    Science.gov (United States)

    Freeman, Andrew R.

    A key part of a broad-based approach to career education in Australian schools is vocational/career guidance. Various vocational guidance programs have been developed for specific groups in Australian society, including work experience, caravans, and micrographics technology for the handicapped; pre-employment courses and a family education center…

  6. Final OSWER Vapor Intrusion Guidance

    Science.gov (United States)

    EPA is preparing to finalize its guidance on assessing and addressing vapor intrusion, which is defined as migration of volatile constituents from contaminated media in the subsurface (soil or groundwater) into the indoor environment. In November 2002, EPA issued draft guidance o...

  7. Interstitial guidance of cancer invasion.

    Science.gov (United States)

    Gritsenko, Pavlo G; Ilina, Olga; Friedl, Peter

    2012-01-01

    Cancer cell invasion into healthy tissues develops preferentially along pre-existing tracks of least resistance, followed by secondary tissue remodelling and destruction. The tissue scaffolds supporting or preventing guidance of invasion vary in structure and molecular composition between organs. In the brain, the guidance is provided by myelinated axons, astrocyte processes, and blood vessels which are used as invasion routes by glioma cells. In the human breast, containing interstitial collagen-rich connective tissue, disseminating breast cancer cells preferentially invade along bundled collagen fibrils and the surface of adipocytes. In both invasion types, physical guidance prompted by interfaces and space is complemented by molecular guidance. Generic mechanisms shared by most, if not all, tissues include (i) guidance by integrins towards fibrillar interstitial collagen and/or laminins and type IV collagen in basement membranes decorating vessels and adipocytes, and, likely, CD44 engaging with hyaluronan; (ii) haptotactic guidance by chemokines and growth factors; and likely (iii) physical pushing mechanisms. Tissue-specific, resticted guidance cues include ECM proteins with restricted expression (tenascins, lecticans), cell-cell interfaces, and newly secreted matrix molecules decorating ECM fibres (laminin-332, thrombospondin-1, osteopontin, periostin). We here review physical and molecular guidance mechanisms in interstitial tissue and brain parenchyma and explore shared principles and organ-specific differences, and their implications for experimental model design and therapeutic targeting of tumour cell invasion.

  8. Restructuring Guidance and Counseling Programs.

    Science.gov (United States)

    Snyder, Beverly A.; Daly, Timothy P.

    1993-01-01

    Briefly reviews counseling profession's call for revitalization and transformation in school counseling and guidance programs. Summarizes one school system's efforts during late 1980s and early 1990s to transform its program from services and crisis orientation into a comprehensive developmental model based on Myrick's developmental guidance and…

  9. 75 FR 54969 - National Emission Standards for Hazardous Air Pollutants From the Portland Cement Manufacturing...

    Science.gov (United States)

    2010-09-09

    ... major and area sources, and for hydrochloric acid (HCl) from new and existing kilns located at major... variability of the best performers by using a statistical formula designed to estimate a MACT floor level that... of the MACT pool. This formula uses a pooled variance (in the s \\2\\ term) that encompasses all the...

  10. 76 FR 17160 - Office of New Reactors; Final Interim Staff Guidance on the Review of Nuclear Power Plant Designs...

    Science.gov (United States)

    2011-03-28

    ... COMMISSION Office of New Reactors; Final Interim Staff Guidance on the Review of Nuclear Power Plant Designs... Guidance (ISG) DC/COL-ISG-021 titled ``Interim Staff Guidance on the Review of Nuclear Power Plant Designs... Nuclear Power Plants,'' March 2007, Standard Review Plan (SRP), Section 8.3.1 and Sections 9.5.4 through...

  11. Pandemic influenza guidance for corporations.

    Science.gov (United States)

    2011-06-01

    The purpose of this guidance document is to assist members of the American College of Occupational and Environmental Medicine (ACOEM), and the organizations for which they work, in managing the impact of a pandemic of influenza or other contagious respiratory disease on patients, employees, and business. This guidance document outlines actions to take before and during an influenza pandemic on the basis of two main strategies: (1) reducing the spread of the virus within facilities; and (2) providing medical care and medical surveillance to client/patient populations. Facilities in which ACOEM members serve include government agencies and the military, universities, and corporations, which generally have multiple locations/sites and their own medical staff, with members responsible for medical care and disease control. This guidance is for organizations with outpatient occupational medicine services, to be used as appropriate. Medical centers should also use guidance that addresses additional employee and external patient care needs.1–3 The ACOEM fully supports implementation of occupational influenza programs that conform with guidance from the Centers for Disease Control and Prevention (CDC), with other guidance from the US Department of Health and Human Services (DHHS), and Occupational Safety and Health Administration (OSHA) regulations and guidance.

  12. International Conference on Harmonisation; S10 Photosafety Evaluation of Pharmaceuticals; guidance for industry; availability. Notice.

    Science.gov (United States)

    2015-01-27

    The Food and Drug Administration (FDA) is announcing the availability of a guidance for industry entitled "S10 Photosafety Evaluation of Pharmaceuticals.'' The guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). This guidance outlines details on when photosafety testing is warranted and on possible assessment strategies; it should be read in conjunction with the ICH M3(R2) guidance, section XIV(14) Photosafety Testing. The purpose of the guidance is to recommend international standards for photosafety assessment and to harmonize such assessments that support human clinical trials and marketing authorization for pharmaceuticals. This guidance finalizes the draft guidance issued on February 4, 2013.

  13. CAREER GUIDANCE EXPERIENCE ABROAD

    Directory of Open Access Journals (Sweden)

    Sergey N. Tolstoguzov

    2015-01-01

    Full Text Available The aim of this paper is to describe the experience of careeroriented activities carried out with students of schools in developed and developing countries. Career Guidance in Russia, despite the vast experience of its implementation, is experiencing serious difficulties. In this regard, it is important to take into account the international experience career-oriented activities, such as in the developed countries of North America and the European Union as well as in several Asian countries with rapidly growing economies and a large demographic potential, taking into account the best variants for the Russian education system. Methods. The experience of career-oriented work undertaken with pupils of the USA, Canada, Israel, France, UK, Germany, Denmark, Sweden, Japan, Singapore, China and India is shown on the basis of the comparative analysis of different publications and information sources. The author has made an attempt to generalize the principles of psycho-pedagogical and administrative assistance in professional self-determination of senior pupils abroad. Scientific novelty. The approaches to career-oriented activities in countries with different levels of economic development are compared for the first time. Some principles are revealed. Firstly, the higher the income level per capita in the country, the greater attention is given to vocational guidance. The politics in the developed countries is based on interests of the individual: children’s acquaintance with the world of professions begins already at younger school and the moment of definitive selfdetermination is postponed till the end of their senior stage of education; the possibility of direction change of professional preparation in case of detection of discrepancy of qualities of the pupil to originally selected profile is provided. Career-oriented activity in developing countries, on the contrary, is rigidly coordinated to requirements of economy and a labour market

  14. CDM Convective Forecast Planning guidance

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The CDM Convective Forecast Planning (CCFP) guidance product provides a foreast of en-route aviation convective hazards. The forecasts are updated every 2 hours and...

  15. Response to work activity guidance

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This memorandum is concerning the request from the FY95 Platte-Kansas Rivers Ecosystem Work Activity Guidance for refuge managers to review the purposes of refuges...

  16. TSCA Inventory Policy and Guidance

    Science.gov (United States)

    A list of numerous policy statements and guidance documents on how to identify certain chemical substances for the purpose of assigning unique and unambiguous descriptions tor each substance listed on the Inventory.

  17. Guidance Systems of Fighter Aircraft

    Directory of Open Access Journals (Sweden)

    K.N. Rajanikanth

    2005-07-01

    Full Text Available Mission performance of a fighter aircraft is crucial for survival and strike capabilities in todays' aerial warfare scenario. The guidance functions of such an aircraft play a vital role inmeeting the requirements and accomplishing the mission success. This paper presents the requirements of precision guidance for various missions of a fighter aircraft. The concept ofguidance system as a pilot-in-loop system is pivotal in understanding and designing such a system. Methodologies of designing such a system are described.

  18. Guidance Systems of Fighter Aircraft

    OpenAIRE

    K.N. Rajanikanth; Rao, R S; P. S. Subramanyam; Ajai Vohra

    2005-01-01

    Mission performance of a fighter aircraft is crucial for survival and strike capabilities in todays' aerial warfare scenario. The guidance functions of such an aircraft play a vital role inmeeting the requirements and accomplishing the mission success. This paper presents the requirements of precision guidance for various missions of a fighter aircraft. The concept ofguidance system as a pilot-in-loop system is pivotal in understanding and designing such a system. Methodologies of designing s...

  19. Guidance molecules in lung cancer

    OpenAIRE

    Nasarre, Patrick; Potiron, Vincent; Drabkin, Harry; Roche, Joëlle

    2010-01-01

    Guidance molecules were first described in the nervous system to control axon outgrowth direction. They are also widely expressed outside the nervous system where they control cell migration, tissue development and establishment of the vascular network. In addition, they are involved in cancer development, tumor angiogenesis and metastasis. This review is primarily focused on their functions in lung cancer and their involvement in lung development is also presented. Five guidance molecule fam...

  20. Flexible scope for ISO 15189 accreditation: a guidance prepared by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group Accreditation and ISO/CEN standards (WG-A/ISO).

    Science.gov (United States)

    Thelen, Marc H M; Vanstapel, Florent J L A; Kroupis, Christos; Vukasovic, Ines; Boursier, Guilaime; Barrett, Edward; Bernabeu Andreu, Francisco; Brguljan, Pika Meško; Brugnoni, Duilio; Lohmander, Maria; Sprongl, Ludek; Vodnik, Tatjana; Ghita, Irina; Vaubourdolle, Michel; Huisman, Willem

    2015-07-01

    The recent revision of ISO15189 has further strengthened its position as the standard for accreditation for medical laboratories. Both for laboratories and their customers it is important that the scope of such accreditation is clear. Therefore the European co-operation for accreditation (EA) demands that the national bodies responsible for accreditation describe the scope of every laboratory accreditation in a way that leaves no room for doubt about the range of competence of the particular laboratories. According to EA recommendations scopes may be fixed, mentioning every single test that is part of the accreditation, or flexible, mentioning all combinations of medical field, examination type and materials for which the laboratory is competent. Up to now national accreditation bodies perpetuate use of fixed scopes, partly by inertia, partly out of fear that a too flexible scope may lead to over-valuation of the competence of laboratories, most countries only use fixed scopes. The EA however promotes use of flexible scopes, since this allows for more readily innovation, which contributes to quality in laboratory medicine. In this position paper, the Working Group Accreditation and ISO/CEN Standards belonging to the Quality and Regulation Committee of the EFLM recommends using an approach that has led to successful introduction of the flexible scope for ISO15189 accreditation as intended in EA-4/17 in The Netherlands. The approach is risk-based, discipline and competence-based, and focuses on defining a uniform terminology transferable across the borders of scientific disciplines, laboratories and countries.

  1. Quality in career guidance: The Danish case

    DEFF Research Database (Denmark)

    Plant, Peter

    2011-01-01

    Quality assurance systems are introduced in career guidance to monitor, control and develop guidance interventions. The Danish case represents at centrally driven, top-down approach......Quality assurance systems are introduced in career guidance to monitor, control and develop guidance interventions. The Danish case represents at centrally driven, top-down approach...

  2. 40 CFR 265.340 - Applicability.

    Science.gov (United States)

    2010-07-01

    ... the maximum achievable control technology (MACT) requirements of part 63, subpart EEE, of this chapter... part 63, subpart EEE, of this chapter. (2) The MACT standards do not replace the closure...

  3. Current Trends in Tactical Missile Guidance

    Directory of Open Access Journals (Sweden)

    S. Vathsal

    2005-07-01

    Full Text Available The problem of tactical missile guidance is very challenging and has been treated using several basic metlfodologies in the past four decades. Major techniques can be grouped underclassical guidance laws, modern guidance laws, l'aws for manoeuvring targets, predictive guidance for endgame scenario, and guidance laws based on intelligent control methods. Each technique has some advantages and disadvantages while implementing in a practical system. Guidance law selection is dictated by nature of flight profile like boost, midcourse, terminal homing, etc, and also miss-distance and a single-shot kill probability. This paper presents a brief survey of the existing techniques and current trends in tactical missile guidance.

  4. ISO19770-1:2012 SAM process guidance

    CERN Document Server

    Canavan, Rory

    2012-01-01

    The pocket guide offers a concise summary of the principles of software asset management as conveyed by ISO 19770-1: 2012, and provides advice and guidance on how to kick-start your own SAM programme - something the Standard alone doesn't offer.

  5. 如何上好新课标指导下的初中实心球课%On How to Teach Stuffed Ball Course in Junior High School under the Guidance of New Curriculum Standard

    Institute of Scientific and Technical Information of China (English)

    白非

    2013-01-01

    School physical education is an important way of culti-vating teenagers' comprehensive quality, and China are continu-ingly reforming sports and health course. The new curriculum standard is very different from traditional teaching method of physical education in that the new one attaches more importance to students' interest in learning. Taking stuffed ball course for an example, this paper summarizes the writer's own teaching prac-tice and experience.%  学校体育则是培养全面发展的青少年的一项重要手段与内容。国家关心青少年体质健康,不断地进行体育与健康课程改革。此次课程改革,从指导思想到内容框架方面均发生了根本性变化。面对新课标的改变,本文从教学方法上谈一下认识与思考。新课标下的体育课与传统模式下的体育课的教学方法有明显的区别。传统教学模式单一、学生难以有效快速地进入学习状态,而新课标注重引导学生、激发学生兴趣,保护学生的学习兴趣。注重学生的自我评价与价值导向,注重课的联系与思考。我就本区域中考项目之一——实心球的教授模式总结一下自己的教学实践与感受。

  6. Autonomous Guidance, Navigation and Control

    Science.gov (United States)

    Bordano, A. J.; Mcswain, G. G.; Fernandes, S. T.

    1991-01-01

    The NASA Autonomous Guidance, Navigation and Control (GN&C) Bridging program is reviewed to demonstrate the program plan and GN&C systems for the Space Shuttle. The ascent CN&C system is described in terms of elements such as the general-purpose digital computers, sensors for the navigation subsystem, the guidance-system software, and the flight-control subsystem. Balloon-based and lidar wind soundings are used for operations assessment on the day of launch, and the guidance software is based on dedicated units for atmospheric powered flight, vacuum powered flight, and abort-specific situations. Optimization of the flight trajectories is discussed, and flight-control responses are illustrated for wavelengths of 500-6000 m. Alternate sensors are used for load relief, and adaptive GN&C systems based on alternate gain synthesis are used for systems failures.

  7. Elevating standards, improving safety.

    Science.gov (United States)

    Clarke, Richard

    2014-08-01

    In our latest 'technical guidance' article, Richard Clarke, sales and marketing director at one of the UK's leading lift and escalator specialists, Schindler, examines some of the key issues surrounding the specification, maintenance, and operation of lifts in hospitals to help ensure the highest standards of safety and reliability.

  8. Agent Based Individual Traffic guidance

    DEFF Research Database (Denmark)

    Wanscher, Jørgen Bundgaard

    2004-01-01

    When working with traffic planning or guidance it is common practice to view the vehicles as a combined mass. >From this models are employed to specify the vehicle supply and demand for each region. As the models are complex and the calculations are equally demanding the regions and the detail...... can be obtained through cellular phone tracking or GPS systems. This information can then be used to provide individual traffic guidance as opposed to the mass information systems of today -- dynamic roadsigns and trafficradio. The goal is to achieve better usage of road and time. The main topic...

  9. Safety of magnetic fusion facilities: Volume 2, Guidance

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    This document provides guidance for the implementation of the requirements identified in Vol. 1 of this Standard. This guidance is intended for the managers, designers, operators, and other personnel with safety responsibilities for facilities designated as magnetic fusion facilities. While Vol. 1 is generally applicable in that requirements there apply to a wide range of fusion facilities, this volume is concerned mainly with large facilities such as the International Thermonuclear Experimental Reactor (ITER). Using a risk-based prioritization, the concepts presented here may also be applied to other magnetic fusion facilities. This volume is oriented toward regulation in the Department of Energy (DOE) environment.

  10. Guidance for evidence-informed policies about health systems: rationale for and challenges of guidance development.

    Science.gov (United States)

    Bosch-Capblanch, Xavier; Lavis, John N; Lewin, Simon; Atun, Rifat; Røttingen, John-Arne; Dröschel, Daniel; Beck, Lise; Abalos, Edgardo; El-Jardali, Fadi; Gilson, Lucy; Oliver, Sandy; Wyss, Kaspar; Tugwell, Peter; Kulier, Regina; Pang, Tikki; Haines, Andy

    2012-01-01

    In the first paper in a three-part series on health systems guidance, Xavier Bosch-Capblanch and colleagues examine how guidance is currently formulated in low- and middle-income countries, and the challenges to developing such guidance.

  11. 78 FR 56752 - Interim Staff Guidance Specific Environmental Guidance for Integral Pressurized Water Reactors...

    Science.gov (United States)

    2013-09-13

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Interim Staff Guidance Specific Environmental Guidance for Integral Pressurized Water Reactors... and operate integral pressurized water reactors (iPWR). This guidance applies to environmental reviews...

  12. DOE technical standards list: Department of Energy standards index

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    This technical standards list (TSL) was prepared for use by personnel involved in the selection and use of US DOE technical standards and other government and non-government standards. This TSL provides listings of current DOE technical standards, non-government standards that have been adopted by DOE, other government documents in which DOE has a recorded interest, and cancelled DOE technical standards. Standards are indexed by type in the appendices to this document. Definitions of and general guidance for the use of standards are also provided.

  13. Autonomous gliding entry guidance with

    Directory of Open Access Journals (Sweden)

    Guo Jie

    2015-10-01

    Full Text Available This paper presents a novel three-dimensional autonomous entry guidance for relatively high lift-to-drag ratio vehicles satisfying geographic constraints and other path constraints. The guidance is composed of onboard trajectory planning and robust trajectory tracking. For trajectory planning, a longitudinal sub-planner is introduced to generate a feasible drag-versus-energy profile by using the interpolation between upper boundary and lower boundary of entry corridor to get the desired trajectory length. The associated magnitude of the bank angle can be specified by drag profile, while the sign of bank angle is determined by lateral sub-planner. Two-reverse mode is utilized to satisfy waypoint constraints and dynamic heading error corridor is utilized to satisfy no-fly zone constraints. The longitudinal and lateral sub-planners are iteratively employed until all of the path constraints are satisfied. For trajectory tracking, a novel tracking law based on the active disturbance rejection control is introduced. Finally, adaptability tests and Monte Carlo simulations of the entry guidance approach are performed. Results show that the proposed entry guidance approach can adapt to different entry missions and is able to make the vehicle reach the prescribed target point precisely in spite of geographic constraints.

  14. Atmospheric guidance techniques and performance

    Science.gov (United States)

    Harpold, J. C.; Gavert, D. E.

    1982-01-01

    The Orbiter entry guidance system controls the Space Shuttle Orbiter from the initial atmospheric penetration point to the point at which an earth relative velocity of 2500 feet/second is reached. At the latter point, control of the Orbiter is transferred to the terminal area energy management system. The entry guidance system is based on the concept that the range to be flown during entry is a unique function of the drag deceleration profile flown throughout the entry. The range prediction during entry is based on analytic equations which are simple drag deceleration functions of earth relative velocity above Mach 10.5 and energy with respect to the earth below Mach 10.5. Flight through the entry corridor is accomplished by linking these simple drag deceleration functions together in series in order to define a drag deceleration reference profile. The results of the first three Space Shuttle missions have not only verified the entry guidance concept but have also demonstrated the stability of the guidance system.

  15. Abortion Information: A Guidance Viewpoint

    Science.gov (United States)

    Wolleat, Patricia L.

    1975-01-01

    A number of questions relating to providing abortion information to teenagers can be raised from legal, ethical and philosophical standpoints. The purpose of this article is to examine abortion information-giving from the perspective of counseling and guidance theory and practice. (Author)

  16. Teacher Guidance of Knowledge Construction

    Science.gov (United States)

    Schwarz, Baruch; Dreyfus, Tommy; Hadas, Nurit; Hershkowitz, Rina

    2004-01-01

    This paper focuses on how teachers guide construction of knowledge in classrooms. We suggest that guidance hinges on the kind of dialogue teachers choose to engage students in. We propose several classroom dialogue types relevant for the construction of knowledge and suggest that critical dialogue is particularly effective for knowledge…

  17. Guidance: Interim Municipal Settlement Policy

    Science.gov (United States)

    Interim guidance and fact sheets regarding settlements involving municipalities or municipal waste under Section 122 CERCLA as amended by SARA. Interim policy sets forth the criteria by which EPA generally determines whether to exercise enforcement discretion to pursue MSW generators and transporters as PRPs.

  18. Agent Based Individual Traffic Guidance

    DEFF Research Database (Denmark)

    Wanscher, Jørgen

    This thesis investigates the possibilities in applying Operations Research (OR) to autonomous vehicular traffic. The explicit difference to most other research today is that we presume that an agent is present in every vehicle - hence Agent Based Individual Traffic guidance (ABIT). The next...

  19. DOE Waste Treatability Group Guidance

    Energy Technology Data Exchange (ETDEWEB)

    Kirkpatrick, T.D.

    1995-01-01

    This guidance presents a method and definitions for aggregating U.S. Department of Energy (DOE) waste into streams and treatability groups based on characteristic parameters that influence waste management technology needs. Adaptable to all DOE waste types (i.e., radioactive waste, hazardous waste, mixed waste, sanitary waste), the guidance establishes categories and definitions that reflect variations within the radiological, matrix (e.g., bulk physical/chemical form), and regulated contaminant characteristics of DOE waste. Beginning at the waste container level, the guidance presents a logical approach to implementing the characteristic parameter categories as part of the basis for defining waste streams and as the sole basis for assigning streams to treatability groups. Implementation of this guidance at each DOE site will facilitate the development of technically defined, site-specific waste stream data sets to support waste management planning and reporting activities. Consistent implementation at all of the sites will enable aggregation of the site-specific waste stream data sets into comparable national data sets to support these activities at a DOE complex-wide level.

  20. Interstitial guidance of cancer invasion.

    NARCIS (Netherlands)

    Gritsenko, P.G.; Ilina, O.; Friedl, P.H.

    2012-01-01

    Cancer cell invasion into healthy tissues develops preferentially along pre-existing tracks of least resistance, followed by secondary tissue remodelling and destruction. The tissue scaffolds supporting or preventing guidance of invasion vary in structure and molecular composition between organs. In

  1. CH Packaging Program Guidance

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2009-06-01

    conducted. This document provides the instructions to be followed to operate, maintain, and test the TRUPACT-II and HalfPACT packaging. The intent of these instructions is to standardize operations. All users will follow these instructions or equivalent instructions that assure operations are safe and meet the requirements of the SARPs.

  2. CH Packaging Program Guidance

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-09-11

    conducted. This document provides the instructions to be followed to operate, maintain, and test the TRUPACT-II and HalfPACT packaging. The intent of these instructions is to standardize operations. All users will follow these instructions or equivalent instructions that assure operations are safe and meet the requirements of the SARPs.

  3. Cooperative Guidance for Multimissile Salvo Attack

    Institute of Scientific and Technical Information of China (English)

    Zhao Shiyu; Zhou Rui

    2008-01-01

    Cooperative guidance problems of multiple missiles are considered in this article. A cooperative guidance scheme, where coordi-nation algorithms and local guidance laws are combined together, is proposed. This scheme actually builds up a hierarchical cooperative guidance architecture, which may provide a general solution to the multimissile cooperative guidance problems. In the case of salvo attacks which require missiles to hit the target simultaneously, both centralized and distributed coordination algorithms are derived based on the impact-time-control guidance (ITCG) law. Numerical simulations are performed to demonstrate the effectiveness of the proposed approaches.

  4. Practical guidance for charting ethics consultations.

    Science.gov (United States)

    Bruce, Courtenay R; Smith, Martin L; Tawose, Olubukunola Mary; Sharp, Richard R

    2014-03-01

    It is generally accepted that appropriate documentation of activities and recommendations of ethics consultants in patients' medical records is critical. Despite this acceptance, the bioethics literature is largely devoid of guidance on key elements of an ethics chart note, the degree of specificity that it should contain, and its stylistic tenor. We aim to provide guidance for a variety of persons engaged in clinical ethics consultation: new and seasoned ethics committee members who are new to ethics consultation, students and trainees in clinical ethics, and those who have significant experience with ethics consultation so that they can reflect on their practice. Toward the goal of promoting quality charting practices in ethics consultations, we propose recommendations on a broad array of questions concerning clinical ethics consultation chart notes, including whether and when to write a chart note, and practical considerations for the tenor, purpose, and content of a chart note. Our broader aim is to promote discussion about good charting practices in clinical ethics, with the hope of contributing to clear standards of excellence in clinical ethics consultation.

  5. Career guidance and counselling for mobilities

    National Research Council Canada - National Science Library

    Zvariková, Mária

    2011-01-01

    In its first part, the article provides a basic overview on guidance and counselling for mobility issues at universities, focusing on the possibilities and role of guidance and counselling for both...

  6. Recent Events in Guidance, Navigation and Control

    Science.gov (United States)

    Polites, Michael E.; Bullman, Jack (Technical Monitor)

    2001-01-01

    This article summarizes recent events in Guidance, Navigation, and Control (GN&C) in space, weapons and missiles, and aircraft. The section on space includes recent developments with the following NASA spacecraft and space vehicles: Near Earth Asteroid Rendezvous, Deep Space 1, Microwave Anisotropy Probe, Earth Observer-1, Compton Gamma Ray Observatory, the International Space Station, X-38, and X-40A. The section on weapons and missiles includes recent developments with the following missiles: Joint Air-to-Surface Standoff Missile, Storm Shadow/Scalp EG precision standoff missile, Hellfire missile, AIM-120C Advanced medium-range air-to-air missile, Derby missile, Arrow 2, and the Standard Missile SM-3. The section on aircraft includes recent developments with the following aircraft: Joint Strike Fighter, X-31, V-22, Couger/SUDer Puma Mk. 2, Predator B 001, and the Unmanned Combat Air Vehicle.

  7. A guidance concept for hypersonic aerospacecrafts

    Science.gov (United States)

    Ishimoto, Shinji

    In this paper a guidance concept for hypersonic re-entry flights is presented. The method uses a closed-form guidance technique based on a drag acceleration reference profile. A guidance law for range control is developed. It employs a physical relation between vehicle energy and range instead of a prediction-correction technique used for Shuttle entry guidance. Simulation results show that the algorithm provides good performance.

  8. 77 FR 46128 - Proposed Revision 0 to Standard Review Plan Section 19.5: Adequacy of Design Features and...

    Science.gov (United States)

    2012-08-02

    ... proposed revision to its Standard Review Plan (SRP), NUREG-0800, ``Standard Review Plan for the Review of... the final approved guidance into the next revision of NUREG-0800. The SRP is guidance for the...

  9. Guidance and Control Software Project Data - Volume 2: Development Documents

    Science.gov (United States)

    Hayhurst, Kelly J. (Editor)

    2008-01-01

    The Guidance and Control Software (GCS) project was the last in a series of software reliability studies conducted at Langley Research Center between 1977 and 1994. The technical results of the GCS project were recorded after the experiment was completed. Some of the support documentation produced as part of the experiment, however, is serving an unexpected role far beyond its original project context. Some of the software used as part of the GCS project was developed to conform to the RTCA/DO-178B software standard, "Software Considerations in Airborne Systems and Equipment Certification," used in the civil aviation industry. That standard requires extensive documentation throughout the software development life cycle, including plans, software requirements, design and source code, verification cases and results, and configuration management and quality control data. The project documentation that includes this information is open for public scrutiny without the legal or safety implications associated with comparable data from an avionics manufacturer. This public availability has afforded an opportunity to use the GCS project documents for DO-178B training. This report provides a brief overview of the GCS project, describes the 4-volume set of documents and the role they are playing in training, and includes the development documents from the GCS project. Volume 2 contains three appendices: A. Guidance and Control Software Development Specification; B. Design Description for the Pluto Implementation of the Guidance and Control Software; and C. Source Code for the Pluto Implementation of the Guidance and Control Software

  10. Guidance and Control Software Project Data - Volume 1: Planning Documents

    Science.gov (United States)

    Hayhurst, Kelly J. (Editor)

    2008-01-01

    The Guidance and Control Software (GCS) project was the last in a series of software reliability studies conducted at Langley Research Center between 1977 and 1994. The technical results of the GCS project were recorded after the experiment was completed. Some of the support documentation produced as part of the experiment, however, is serving an unexpected role far beyond its original project context. Some of the software used as part of the GCS project was developed to conform to the RTCA/DO-178B software standard, "Software Considerations in Airborne Systems and Equipment Certification," used in the civil aviation industry. That standard requires extensive documentation throughout the software development life cycle, including plans, software requirements, design and source code, verification cases and results, and configuration management and quality control data. The project documentation that includes this information is open for public scrutiny without the legal or safety implications associated with comparable data from an avionics manufacturer. This public availability has afforded an opportunity to use the GCS project documents for DO-178B training. This report provides a brief overview of the GCS project, describes the 4-volume set of documents and the role they are playing in training, and includes the planning documents from the GCS project. Volume 1 contains five appendices: A. Plan for Software Aspects of Certification for the Guidance and Control Software Project; B. Software Development Standards for the Guidance and Control Software Project; C. Software Verification Plan for the Guidance and Control Software Project; D. Software Configuration Management Plan for the Guidance and Control Software Project; and E. Software Quality Assurance Activities.

  11. The Self in Guidance: Assumptions and Challenges.

    Science.gov (United States)

    Edwards, Richard; Payne, John

    1997-01-01

    Examines the assumptions of "self" made in the professional and managerial discourses of guidance. Suggests that these assumptions obstruct the capacity of guidance workers to explain their own practices. Drawing on contemporary debates over identity, modernity, and postmodernity, argues for a more explicit debate about the self in guidance. (RJM)

  12. 78 FR 53792 - Draft Guidance for Reciprocity

    Science.gov (United States)

    2013-08-30

    ...The U.S. Nuclear Regulatory Commission (NRC) is revising its licensing guidance for reciprocity. The NRC is requesting public comment on draft NUREG-1556, Volume 19, Revision 1, ``Consolidated Guidance about Materials Licenses: Guidance for Agreement State Licensees about NRC Form 241 `Report of Proposed Activities in Non- Agreement States, Areas of Exclusive Federal Jurisdiction, of Offshore......

  13. Providing Career Guidance for Young Women.

    Science.gov (United States)

    Colby, Pamela G.

    This module is directed at personnel working or planning to work in the areas of guidance, counseling, placement and follow-through in junior and senior high school settings, grades 7-12. The module topic is career guidance for young women of junior and senior high school age, aand the focus will be on providing nonbiased career guidance which…

  14. Reentry guidance for Space Shuttle

    Science.gov (United States)

    Causey, W.; Sohoni, V.

    1973-01-01

    An explicit guidance scheme is outlined which provides the appropriate energy management in order for the shuttle orbiter to reach any location within the required footprint. Considering the orbiter as entering the earth's atmosphere, expressions for the downrange, crossrange, and the time of the termination of the entry phase as functions of the control variables are developed. Performing an order-of-magnitude analysis of the terms in these expressions, only dominant terms are retained. Analytical expressions for the elements of the sensitivity matrix which represents the partial derivatives of the desired range with respect to control variables are formulated. Using the Gauss-Jordan inversion technique, the required change in guidance commands as a function of the deviations in the downrange and crossrange are explicitly computed.

  15. Reentry guidance for Space Shuttle

    Science.gov (United States)

    Causey, W.; Sohoni, V.

    1973-01-01

    An explicit guidance scheme is outlined which provides the appropriate energy management in order for the shuttle orbiter to reach any location within the required footprint. Considering the orbiter as entering the earth's atmosphere, expressions for the downrange, crossrange, and the time of the termination of the entry phase as functions of the control variables are developed. Performing an order-of-magnitude analysis of the terms in these expressions, only dominant terms are retained. Analytical expressions for the elements of the sensitivity matrix which represents the partial derivatives of the desired range with respect to control variables are formulated. Using the Gauss-Jordan inversion technique, the required change in guidance commands as a function of the deviations in the downrange and crossrange are explicitly computed.

  16. Teleautonomous guidance for mobile robots

    Science.gov (United States)

    Borenstein, J.; Koren, Y.

    1990-01-01

    Teleautonomous guidance (TG), a technique for the remote guidance of fast mobile robots, has been developed and implemented. With TG, the mobile robot follows the general direction prescribed by an operator. However, if the robot encounters an obstacle, it autonomously avoids collision with that obstacle while trying to match the prescribed direction as closely as possible. This type of shared control is completely transparent and transfers control between teleoperation and autonomous obstacle avoidance gradually. TG allows the operator to steer vehicles and robots at high speeds and in cluttered environments, even without visual contact. TG is based on the virtual force field (VFF) method, which was developed earlier for autonomous obstacle avoidance. The VFF method is especially suited to the accommodation of inaccurate sensor data (such as that produced by ultrasonic sensors) and sensor fusion, and allows the mobile robot to travel quickly without stopping for obstacles.

  17. Microfluidic control of axonal guidance

    Science.gov (United States)

    Gu, Ling; Black, Bryan; Ordonez, Simon; Mondal, Argha; Jain, Ankur; Mohanty, Samarendra

    2014-10-01

    The precision of axonal pathfinding and the accurate formation of functional neural circuitry are crucial for an organism during development as well as during adult central and peripheral nerve regeneration. While chemical cues are believed to be primarily responsible for axonal pathfinding, we hypothesize that forces due to localized fluid flow may directly affect neuronal guidance during early organ development. Here, we report direct evidence of fluid flow influencing axonal migration, producing turning angles of up to 90°. Microfluidic flow simulations indicate that an axon may experience significant bending force due to cross-flow, which may contribute to the observed axonal turning. This method of flow-based guidance was successfully used to fasciculate one advancing axon onto another, showcasing the potential of this technique to be used for the formation of in vitro neuronal circuits.

  18. 2011 Army Strategic Planning Guidance

    Science.gov (United States)

    2011-03-25

    TESI ) of 22,000 Soldiers, the Army’s total force by the end of the mid-term period is programmed to be 520K (AC). We will achieve a more...dwell ratios, extending TESI authority to adequately man deploying units and sustain the All-Volunteer Force, right-sizing the generating force, and... TESI Temporary End-Strength Increase WMD Weapons of Mass Destruction 2011 ARMY STRATEGIC PLANNING GUIDANCE Page 19 2011

  19. 14 CFR 77.3 - Standards.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Standards. 77.3 Section 77.3 Aeronautics... AFFECTING NAVIGABLE AIRSPACE General § 77.3 Standards. (a) The standards established in this part for... section 16 of the Federal Airport Act; (3) Developing technical standards and guidance in the design...

  20. Optimum PN Guidance Law for Maneuvering Target

    Institute of Scientific and Technical Information of China (English)

    SUN Bao-cai; QI Zai-kang

    2007-01-01

    An optimum PN guidance law for maneuvering target is developed using optimal control theory. By estimating the target position and setting the cost function, the guidance law can be deduced even without knowing the missile lateral acceleration. Since the quadratic cost function can make a compromise between the miss distance andthe control constraint, the optimum guidance law obtained is more general. Also, introduced line of sight rate as the input, a practical form of this guidance law is derived. The simulation results show the effectiveness of the guidance laws.

  1. Guidance and Control Software Project Data - Volume 3: Verification Documents

    Science.gov (United States)

    Hayhurst, Kelly J. (Editor)

    2008-01-01

    The Guidance and Control Software (GCS) project was the last in a series of software reliability studies conducted at Langley Research Center between 1977 and 1994. The technical results of the GCS project were recorded after the experiment was completed. Some of the support documentation produced as part of the experiment, however, is serving an unexpected role far beyond its original project context. Some of the software used as part of the GCS project was developed to conform to the RTCA/DO-178B software standard, "Software Considerations in Airborne Systems and Equipment Certification," used in the civil aviation industry. That standard requires extensive documentation throughout the software development life cycle, including plans, software requirements, design and source code, verification cases and results, and configuration management and quality control data. The project documentation that includes this information is open for public scrutiny without the legal or safety implications associated with comparable data from an avionics manufacturer. This public availability has afforded an opportunity to use the GCS project documents for DO-178B training. This report provides a brief overview of the GCS project, describes the 4-volume set of documents and the role they are playing in training, and includes the verification documents from the GCS project. Volume 3 contains four appendices: A. Software Verification Cases and Procedures for the Guidance and Control Software Project; B. Software Verification Results for the Pluto Implementation of the Guidance and Control Software; C. Review Records for the Pluto Implementation of the Guidance and Control Software; and D. Test Results Logs for the Pluto Implementation of the Guidance and Control Software.

  2. Analysing Interplanetary Probe Guidance Accuracy

    Directory of Open Access Journals (Sweden)

    S. V. Sukhova

    2016-01-01

    Full Text Available The paper presents a guidance accuracy analysis and estimates delta-v budget required to provide the trajectory correction maneuvers for direct interplanetary flights (without midcourse gravity assists. The analysis takes into consideration the orbital hyperbolic injection errors (depend on a selected launch vehicle and ascent trajectory and the uncertainties of midcourse correction maneuvers.The calculation algorithm is based on Monte Carlo simulation and Danby’s matrix methods (the matrizant of keplerian motion. Danby’s method establishes a link between the errors of the spacecraft state vectors at different flight times using the reference keplerian orbit matrizant. Utilizing the nominal trajectory parameters and the covariance matrix of launch vehicle injection errors the random perturbed orbits are generated and required velocity corrections are calculated. The next step is to simulate midcourse maneuver performance uncertainty using the midcourse maneuver covariance matrix. The obtained trajectory correction impulses and spacecraft position errors are statistically processed to compute required delta-v budget and dispersions ellipse parameters for different prediction intervals.As an example, a guidance accuracy analysis has been conducted for a 2022 mission to Mars and a Venus mission in 2026. The paper considers one and two midcourse correction options, as well as utilization of two different launch vehicles.The presented algorithm based on Monte Carlo simulation and Danby’s methods provides preliminary evaluation for midcourse corrections delta-v budget and spacecraft position error. The only data required for this guidance accuracy analysis are a reference keplerian trajectory and a covariance matrix of the injection errors. Danby’s matrix method allows us to take into account also the other factors affecting the trajectory thereby increasing the accuracy of analysis.

  3. Regulatory guidance on soil cover systems

    Energy Technology Data Exchange (ETDEWEB)

    Kane, J.D. [Nuclear Regulatory Commission, Washington, DC (United States)

    1991-12-31

    The US Nuclear Regulatory Commission (NRC) in September 1991, completed revisions to 14 sections of the Standard Review Plan (SRP) for the Review of a License Application for a Low-Level Radioactive Waste Disposal Facility. The major purposes of the SRP are to ensure the quality and uniformity of the NRC staff`s safety reviews, and to present a well-defined base from which to evaluate the acceptability of information and data provided in the Safety Analysis Report (SAR) portion of the license application. SRP 3.2, entitled, Design Considerations for Normal and Abnormal/Accident Conditions, was one of the sections that was revised by the NRC staff. This revision was completed to provide additional regulatory guidance on the important considerations that need to be addressed for the proper design and construction of soil cover systems that are to be placed over the LLW. The cover system over the waste is acknowledged to be one of the most important engineered barriers for the long-term stable performance of the disposal facility. The guidance in revised SRP 3.2 summarizes the previous efforts and recommendations of the US Army Corps of Engineers (COE), and a peer review panel on the placement of soil cover systems. NRC published these efforts in NUREG/CR-5432. The discussions in this paper highlight selected recommendations on soil cover issues that the NRC staff considers important for ensuring the safe, long-term performance of the soil cover systems. The development phases to be discussed include: (1) cover design; (2) cover material selection; (3) laboratory and field testing; (4) field placement control and acceptance; and (5) penetrations through the constructed covers.

  4. Precision optical navigation guidance system

    Science.gov (United States)

    Starodubov, D.; McCormick, K.; Nolan, P.; Johnson, D.; Dellosa, M.; Volfson, L.; Fallahpour, A.; Willner, A.

    2016-05-01

    We present the new precision optical navigation guidance system approach that provides continuous, high quality range and bearing data to fixed wing aircraft during landing approach to an aircraft carrier. The system uses infrared optical communications to measure range between ship and aircraft with accuracy and precision better than 1 meter at ranges more than 7.5 km. The innovative receiver design measures bearing from aircraft to ship with accuracy and precision better than 0.5 mRad. The system provides real-time range and bearing updates to multiple aircraft at rates up to several kHz, and duplex data transmission between ship and aircraft.

  5. Quality guidance and quality formation

    DEFF Research Database (Denmark)

    Poulsen, Carsten Stig; Juhl, Hans Jørn; Kristensen, Kai

    1996-01-01

    This paper presents an extension of the quality guidance model of Steenkamp and van Trijp that includes consumer quality formation processes. Quality expectations and quality experiences are seen as antecedents of perceived overall product quality conceptual model is applied using LISREL to a data...... set on Danish butter cookies. Five plausible models of the relation between expectation, experience and perceived product quality are estimated. Finally one model is selected on the basis of three criteria: chi-square, RMSEA and AIC: The results show a model where expectations are indirectly related...... to perceived quality through experience. Udgivelsesdato: APR...

  6. Quality guidance and quality formation

    DEFF Research Database (Denmark)

    Poulsen, Carsten Stig; Juhl, Hans Jørn; Kristensen, Kai

    1996-01-01

    This paper presents an extension of the quality guidance model of Steenkamp and van Trijp that includes consumer quality formation processes. Quality expectations and quality experiences are seen as antecedents of perceived overall product quality conceptual model is applied using LISREL to a data...... set on Danish butter cookies. Five plausible models of the relation between expectation, experience and perceived product quality are estimated. Finally one model is selected on the basis of three criteria: chi-square, RMSEA and AIC: The results show a model where expectations are indirectly related...... to perceived quality through experience. Udgivelsesdato: APR...

  7. Orthobiologic Interventions Using Ultrasound Guidance.

    Science.gov (United States)

    Malanga, Gerard; Abdelshahed, Dena; Jayaram, Prathap

    2016-08-01

    The application of regenerative therapies for the treatment of musculoskeletal conditions has emerged over the last decade with recent acceleration. These include prolotherapy, platelet-rich plasma, and mesenchymal stem cell therapy. These strategies augment the body's innate physiology to heal pathologic processes. This article presents an overview of platelet-rich plasma and mesenchymal stem cell therapy for the treatment of musculoskeletal injuries. A brief literature review is included, as are techniques for the use of ultrasound guidance to assist with these procedures. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. SPAR-H Step-by-Step Guidance

    Energy Technology Data Exchange (ETDEWEB)

    April M. Whaley; Dana L. Kelly; Ronald L. Boring; William J. Galyean

    2012-06-01

    Step-by-step guidance was developed recently at Idaho National Laboratory for the US Nuclear Regulatory Commission on the use of the Standardized Plant Analysis Risk-Human Reliability Analysis (SPAR-H) method for quantifying Human Failure Events (HFEs). This work was done to address SPAR-H user needs, specifically requests for additional guidance on the proper application of various aspects of the methodology. This paper overviews the steps of the SPAR-H analysis process and highlights some of the most important insights gained during the development of the step-by-step directions. This supplemental guidance for analysts is applicable when plant-specific information is available, and goes beyond the general guidance provided in existing SPAR-H documentation. The steps highlighted in this paper are: Step-1, Categorizing the HFE as Diagnosis and/or Action; Step-2, Rate the Performance Shaping Factors; Step-3, Calculate PSF-Modified HEP; Step-4, Accounting for Dependence, and; Step-5, Minimum Value Cutoff.

  9. Hands-Free System for Bronchoscopy Planning and Guidance.

    Science.gov (United States)

    Khare, Rahul; Bascom, Rebecca; Higgins, William E

    2015-12-01

    Bronchoscopy is a commonly used minimally invasive procedure for lung-cancer staging. In standard practice, however, physicians differ greatly in their levels of performance. To address this concern, image-guided intervention (IGI) systems have been devised to improve procedure success. Current IGI bronchoscopy systems based on virtual bronchoscopic navigation (VBN), however, require involvement from the attending technician. This lessens physician control and hinders the overall acceptance of such systems. We propose a hands-free VBN system for planning and guiding bronchoscopy. The system introduces two major contributions. First, it incorporates a new procedure-planning method that automatically computes airway navigation plans conforming to the physician's bronchoscopy training and manual dexterity. Second, it incorporates a guidance strategy for bronchoscope navigation that enables user-friendly system control via a foot switch, coupled with a novel position-verification mechanism. Phantom studies verified that the system enables smooth operation under physician control, while also enabling faster navigation than an existing technician-assisted VBN system. In a clinical human study, we noted a 97% bronchoscopy navigation success rate, in line with existing VBN systems, and a mean guidance time per diagnostic site = 52 s. This represents a guidance time often nearly 3 min faster per diagnostic site than guidance times reported for other technician-assisted VBN systems. Finally, an ergonomic study further asserts the system's acceptability to the physician and long-term potential.

  10. Flight Guidance System Requirements Specification

    Science.gov (United States)

    Miller, Steven P.; Tribble, Alan C.; Carlson, Timothy M.; Danielson, Eric J.

    2003-01-01

    This report describes a requirements specification written in the RSML-e language for the mode logic of a Flight Guidance System of a typical regional jet aircraft. This model was created as one of the first steps in a five-year project sponsored by the NASA Langley Research Center, Rockwell Collins Inc., and the Critical Systems Research Group of the University of Minnesota to develop new methods and tools to improve the safety of avionics designs. This model will be used to demonstrate the application of a variety of methods and techniques, including safety analysis of system and subsystem requirements, verification of key properties using theorem provers and model checkers, identification of potential sources mode confusion in system designs, partitioning of applications based on the criticality of system hazards, and autogeneration of avionics quality code. While this model is representative of the mode logic of a typical regional jet aircraft, it does not describe an actual or planned product. Several aspects of a full Flight Guidance System, such as recovery from failed sensors, have been omitted, and no claims are made regarding the accuracy or completeness of this specification.

  11. 78 FR 68030 - Possible Models for the Administration and Support of Discipline-Specific Guidance Groups for...

    Science.gov (United States)

    2013-11-13

    ... Discipline- Specific Guidance Groups for Forensic Science AGENCY: National Institute of Standards and... Administration and Support of Discipline-Specific Guidance Groups for Forensic Science. Due to the lack of...) announced that it was soliciting input for possible models for the administration and support of...

  12. Optimal terminal guidance for exoatmospheric interception

    Directory of Open Access Journals (Sweden)

    Yu Wenbin

    2016-08-01

    Full Text Available In this study, two optimal terminal guidance (OTG laws, one of which takes into account the final velocity vector constraint, are developed for exoatmospheric interception using optimal control theory. In exoatmospheric interception, because the proposed guidance laws give full consideration to the effect of gravity, they consume much less fuel than the traditional guidance laws while requiring a light computational load. In the development of the guidance laws, a unified optimal guidance problem is put forward, where the final velocity vector constraint can be considered or neglected by properly adjusting a parameter in the cost function. To make this problem analytically solvable, a linear model is used to approximate the gravity difference, the difference of the gravitational accelerations of the target and interceptor. Additionally, an example is provided to show that some achievements of this study can be used to significantly improve the fuel efficiency of the pulsed guidance employed by the interceptor whose divert thrust level is fixed.

  13. Optimal terminal guidance for exoatmospheric interception

    Institute of Scientific and Technical Information of China (English)

    Yu Wenbin; Chen Wanchun; Yang Liang; Liu Xiaoming; Zhou Hao

    2016-01-01

    In this study, two optimal terminal guidance (OTG) laws, one of which takes into account the final velocity vector constraint, are developed for exoatmospheric interception using optimal control theory. In exoatmospheric interception, because the proposed guidance laws give full consideration to the effect of gravity, they consume much less fuel than the traditional guidance laws while requiring a light computational load. In the development of the guidance laws, a unified optimal guidance problem is put forward, where the final velocity vector constraint can be consid-ered or neglected by properly adjusting a parameter in the cost function. To make this problem ana-lytically solvable, a linear model is used to approximate the gravity difference, the difference of the gravitational accelerations of the target and interceptor. Additionally, an example is provided to show that some achievements of this study can be used to significantly improve the fuel efficiency of the pulsed guidance employed by the interceptor whose divert thrust level is fixed.

  14. International governmental agencies and career guidance

    OpenAIRE

    Conger, Stuart

    1999-01-01

    The international Organization for Economic Cooperation and Development (OECD), like many national and international organizations concerned with economic development believes that career guidance has an important role in promoting the development of a country's human resources. (Mapping the future: Young People and career guidance OECD, 1996). Generally the economic development agencies always recommend that career guidance services should be strengthened. Too frequently, however, they do no...

  15. 评判性思维教学方法引导下规范化培训护士与实习护士评判性思维能力调查研究%A study on the evaluation of critical thinking ability of nurses with standardized training and student nurses under the guidance of critical thinking teaching method

    Institute of Scientific and Technical Information of China (English)

    杨林; 邓小梅; 朱汝妃; 陈华

    2015-01-01

    Objective:To evaluate the critical thinKing ability of nurses with standardized training and student nurses under the guidance of critical thinKing teaching method. Methods:193 nurses who received standardized training in our hospital were divided into two groups, of them 92 nurses who had one - year training experience were taKen as the first stage group and the other 101 nurses who had two - year training experience were taKen as the second stage group;other 207 student nurses who had clinical practice in our hospital were selected, 92 nurses who had practice less than 3 months were taKen as the preparatory group and the other 115 nurses who already had one - year practice were taKen as the maturity group. The nurses in the four groups were respectively investigated by using critical thinKing attitude questionnaire(the Chinese version). Results:The scores of critical thinKing ability of the nurses were significantly higher in the maturity group than the preparatory group(P < 0. 05);the scores of critical thinKing ability of the nurses in the maturity group were significantly higher than those in the standardized training group(P < 0. 05);the scores of critical thinKing ability of the nurses in the maturity group were significantly higher than those in the first stage group and the second stage group(P < 0. 05). Conclusion:The critical thinKing ability of the student nurses and the nurses with standardized training significantly improved under the guidance of critical thinKing teaching meth-od,but the hospital mangers should focus on strengthening the critical thinKing ability of finding the truth and developing thirst.%目的:探讨评判性思维教学方法引导下规范化培训护士与实习护士评判性思维能力。方法:将于我院工作的193名规范化培训护士中满1年培训经历的92名护士设为一阶段组,将满两年培训经历的101名护士设为二阶段组;同期选取我院实习的207名护士,

  16. Hybrid Guidance System for Relative Navigation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Future NASA architectures and missions will involve many distributed platforms that must work together. This in turn requires guidance, navigation and control...

  17. Percutaneous needle placement using laser guidance: a practical solution

    Science.gov (United States)

    Xu, Sheng; Kapoor, Ankur; Abi-Jaoudeh, Nadine; Imbesi, Kimberly; Hong, Cheng William; Mazilu, Dumitru; Sharma, Karun; Venkatesan, Aradhana M.; Levy, Elliot; Wood, Bradford J.

    2013-03-01

    In interventional radiology, various navigation technologies have emerged aiming to improve the accuracy of device deployment and potentially the clinical outcomes of minimally invasive procedures. While these technologies' performance has been explored extensively, their impact on daily clinical practice remains undetermined due to the additional cost and complexity, modification of standard devices (e.g. electromagnetic tracking), and different levels of experience among physicians. Taking these factors into consideration, a robotic laser guidance system for percutaneous needle placement is developed. The laser guidance system projects a laser guide line onto the skin entry point of the patient, helping the physician to align the needle with the planned path of the preoperative CT scan. To minimize changes to the standard workflow, the robot is integrated with the CT scanner via optical tracking. As a result, no registration between the robot and CT is needed. The robot can compensate for the motion of the equipment and keep the laser guide line aligned with the biopsy path in real-time. Phantom experiments showed that the guidance system can benefit physicians at different skill levels, while clinical studies showed improved accuracy over conventional freehand needle insertion. The technology is safe, easy to use, and does not involve additional disposable costs. It is our expectation that this technology can be accepted by interventional radiologists for CT guided needle placement procedures.

  18. 78 FR 37231 - Guidance for Industry; Guidance on Abbreviated New Drug Applications: Stability Testing of Drug...

    Science.gov (United States)

    2013-06-20

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry; Guidance on Abbreviated New Drug... the availability of a guidance for industry entitled ``ANDAs: Stability Testing of Drug Substances and... generic drug review, FDA is recommending that the generic drug industry follow the approach in...

  19. Guidance for evidence-informed policies about health systems: rationale for and challenges of guidance development.

    Directory of Open Access Journals (Sweden)

    Xavier Bosch-Capblanch

    Full Text Available In the first paper in a three-part series on health systems guidance, Xavier Bosch-Capblanch and colleagues examine how guidance is currently formulated in low- and middle-income countries, and the challenges to developing such guidance.

  20. Waste treatability guidance program. User`s guide. Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Toth, C.

    1995-12-21

    DOE sites across the country generate and manage radioactive, hazardous, mixed, and sanitary wastes. It is necessary for each site to find the technologies and associated capacities required to manage its waste. One role of DOE HQ Office of Environmental Restoration and Waste Management is to facilitate the integration of the site- specific plans into coherent national plans. DOE has developed a standard methodology for defining and categorizing waste streams into treatability groups based on characteristic parameters that influence waste management technology needs. This Waste Treatability Guidance Program automates the Guidance Document for the categorization of waste information into treatability groups; this application provides a consistent implementation of the methodology across the National TRU Program. This User`s Guide provides instructions on how to use the program, including installations instructions and program operation. This document satisfies the requirements of the Software Quality Assurance Plan.

  1. 78 FR 35072 - Proposed Revision to Strategies and Guidance to Address Loss of Large Areas of the Plant Due to...

    Science.gov (United States)

    2013-06-11

    ... comment on NUREG-0800, ``Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power... NUREG-0800. The SRP is guidance for the NRC staff. The SRP is not a substitute for the NRC's...

  2. NAFTA Guidance Document on Data Requirements for Tolerances on Imported Commodities in the United States and Canada

    Science.gov (United States)

    The purpose of this document is to provide detailed guidance on data requirements that meet the North American Free Trade Agreement standards for the establishment of pesticide import tolerances or maximum residue levels in Canada and the United States.

  3. Driving change : sustainable development action plans Guidance

    OpenAIRE

    Sustainable Development Commission

    2008-01-01

    This guidance builds upon the Sustainable Development Commission’s previous guidance, Getting Started (August 2005), which set out the basic elements that the Sustainable Development Commission would expect to see in a good Sustainable Development Action Plan. Publisher PDF Original published August 2005.

  4. Minimum variation guidance laws for interceptor missiles

    NARCIS (Netherlands)

    Weiss, M.; Shima, T.

    2014-01-01

    This paper introduces a new approach to guidance law design using linear quadratic optimal control theory, minimizing throughout the engagement the variation of the control input as well as the integral control effort. The guidance law is derived for arbitrary order missile dynamics and target maneu

  5. Career Guidance and Public Mental Health

    Science.gov (United States)

    Robertson, Peter J.

    2013-01-01

    Career guidance may have the potential to promote public health by contributing positively to both the prevention of mental health conditions and to population level well-being. The policy implications of this possibility have received little attention. Career guidance agencies are well placed to reach key target groups. Producing persuasive…

  6. 75 FR 53023 - Sound Incentive Compensation Guidance

    Science.gov (United States)

    2010-08-30

    ... principles and the guidance are consistent with the Principles for Sound Compensation Practices adopted by... of Management and Budget (OMB) for review, as required by the Paperwork Reduction Act. Today, OTS is.... Description: The guidance is based on three key principles that are designed to ensure that incentive...

  7. Driving change : sustainable development action plans Guidance

    OpenAIRE

    Sustainable Development Commission

    2008-01-01

    This guidance builds upon the Sustainable Development Commission’s previous guidance, Getting Started (August 2005), which set out the basic elements that the Sustainable Development Commission would expect to see in a good Sustainable Development Action Plan. Publisher PDF Original published August 2005.

  8. Flight Guidance System Validation Using SPIN

    Science.gov (United States)

    Naydich, Dimitri; Nowakowski, John

    1998-01-01

    To verify the requirements for the mode control logic of a Flight Guidance System (FGS) we applied SPIN, a widely used software package that supports the formal verification of distributed systems. These requirements, collectively called the FGS specification, were developed at Rockwell Avionics & Communications and expressed in terms of the Consortium Requirements Engineering (CoRE) method. The properties to be verified are the invariants formulated in the FGS specification, along with the standard properties of consistency and completeness. The project had two stages. First, the FGS specification and the properties to be verified were reformulated in PROMELA, the input language of SPIN. This involved a semantics issue, as some constructs of the FGS specification do not have well-defined semantics in CoRE. Then we attempted to verify the requirements' properties using the automatic model checking facilities of SPIN. Due to the large size of the state space of the FGS specification an exhaustive state space analysis with SPIN turned out to be impossible. So we used the supertrace model checking procedure of SPIN that provides for a partial analysis of the state space. During this process, we found some subtle errors in the FGS specification.

  9. DOE standard: Radiological control

    Energy Technology Data Exchange (ETDEWEB)

    1999-07-01

    The Department of Energy (DOE) has developed this Standard to assist line managers in meeting their responsibilities for implementing occupational radiological control programs. DOE has established regulatory requirements for occupational radiation protection in Title 10 of the Code of Federal Regulations, Part 835 (10 CFR 835), ``Occupational Radiation Protection``. Failure to comply with these requirements may lead to appropriate enforcement actions as authorized under the Price Anderson Act Amendments (PAAA). While this Standard does not establish requirements, it does restate, paraphrase, or cite many (but not all) of the requirements of 10 CFR 835 and related documents (e.g., occupational safety and health, hazardous materials transportation, and environmental protection standards). Because of the wide range of activities undertaken by DOE and the varying requirements affecting these activities, DOE does not believe that it would be practical or useful to identify and reproduce the entire range of health and safety requirements in this Standard and therefore has not done so. In all cases, DOE cautions the user to review any underlying regulatory and contractual requirements and the primary guidance documents in their original context to ensure that the site program is adequate to ensure continuing compliance with the applicable requirements. To assist its operating entities in achieving and maintaining compliance with the requirements of 10 CFR 835, DOE has established its primary regulatory guidance in the DOE G 441.1 series of Guides. This Standard supplements the DOE G 441.1 series of Guides and serves as a secondary source of guidance for achieving compliance with 10 CFR 835.

  10. MGR COMPLIANCE PROGRAM GUIDANCE PACKAGE FOR RADIATION PROTECTION EQUIPMENT, INSTRUMENTATION AND FACILITIES

    Energy Technology Data Exchange (ETDEWEB)

    N/A

    2000-02-01

    This Compliance Program Guidance Package identifies the regulatory guidance and industry codes and standards addressing radiation protection equipment, instrumentation, and support facilities considered to be appropriate for radiation protection at the Monitored Geologic Repository (MGR). Included are considerations relevant to radiation monitoring instruments, calibration, contamination control and decontamination, respiratory protection equipment, and general radiation protection facilities. The scope of this Guidance Package does not include design guidance relevant to criticality monitoring, area radiation monitoring, effluent monitoring, and airborne radioactivity monitoring systems since they are considered to be the topics of specific design and construction requirements (i.e., ''fixed'' or ''built-in'' systems). This Guidance Package does not address radiation protection design issues; it addresses the selection and calibration of radiation monitoring instrumentation to the extent that the guidance is relevant to the operational radiation protection program. Radon and radon progeny monitoring instrumentation is not included in the Guidance Package since such naturally occurring radioactive materials do not fall within the NRC's jurisdiction at the MGR.

  11. Space shuttle guidance, navigation, and control design equations. Volume 3: Guidance

    Science.gov (United States)

    1973-01-01

    Space shuttle guidance, navigation, and control design equations are presented. The space-shuttle mission includes three relatively distinct guidance phases which are discussed; atmospheric boost, which is characterized by an adaptive guidance law; extra-atmospheric activities; and re-entry activities, where aerodynamic surfaces are the principal effectors. Guidance tasks include pre-maneuver targeting and powered flight guidance, where powered flight is defined to include the application of aerodynamic forces as well as thruster forces. A flow chart which follows guidance activities throughout the mission from the pre-launch phase through touchdown is presented. The main guidance programs and subroutines used in each phase of a typical rendezvous mission are listed. Detailed software requirements are also presented.

  12. 76 FR 63676 - Final Division of Safety Systems Interim Staff Guidance DSS-ISG-2010-01: Staff Guidance Regarding...

    Science.gov (United States)

    2011-10-13

    ... COMMISSION Final Division of Safety Systems Interim Staff Guidance DSS-ISG- 2010-01: Staff Guidance Regarding... final Division of Safety Systems Interim Staff Guidance, (DSS-ISG) DSS- ISG-2010-01, ``Staff Guidance... guidance to the NRC staff reviewer to address the increased complexity of recent spent fuel pool...

  13. Optofluidic control of axonal guidance

    Science.gov (United States)

    Gu, Ling; Ordonez, Simon; Black, Bryan; Mohanty, Samarendra K.

    2013-03-01

    Significant efforts are being made for control on axonal guidance due to its importance in nerve regeneration and in the formation of functional neuronal circuitry in-vitro. These include several physical (topographic modification, optical force, and electric field), chemical (surface functionalization cues) and hybrid (electro-chemical, photochemical etc) methods. Here, we report comparison of the effect of linear flow versus microfluidic flow produced by an opticallydriven micromotor in guiding retinal ganglion axons. A circularly polarized laser tweezers was used to hold, position and spin birefringent calcite particle near growth cone, which in turn resulted in microfluidic flow. The flow rate and resulting shear-force on axons could be controlled by a varying the power of the laser tweezers beam. The calcite particles were placed separately in one chamber and single particle was transported through microfluidic channel to another chamber containing the retina explant. In presence of flow, the turning of axons was found to strongly correlate with the direction of flow. Turning angle as high as 90° was achieved. Optofluidic-manipulation can be applied to other types of mammalian neurons and also can be extended to stimulate mechano-sensing neurons.

  14. Augmented Reality Repair Guidance System

    Directory of Open Access Journals (Sweden)

    Sidharth Bhatia

    2012-07-01

    Full Text Available The daily life of a common man revolves around various forms of appliances/gadgets he uses throughout the day such as a mobile phone, laptop, printer, microwave oven, washing machine, etc. Although these appliances/gadgets are taken by most of the people for granted, the problem occurs when any of these things do not work as they are expected to. Getting them to the repair shops for every small glitch is expensive as well as time consuming. Although most of the companies which produce these appliances/gadgets do supply them with basic manuals, which deal with how to solve these minor issues, but reading them and at the same time repairing the corresponding appliance/gadget can be a frustrating task at times. These problems can be reduced to a large extent if some kind of live guidance is available. In this paper we propose a method to do so with the help of an augmented reality based system that will guide the user to carry out small scale repair jobs on these gadgets. All that is required is a decent webcam and a computing device, with a processor of 1 GHz or more and a display screen.

  15. 78 FR 54949 - Major Project Financial Plan Guidance

    Science.gov (United States)

    2013-09-06

    ... TRANSPORTATION Federal Highway Administration Major Project Financial Plan Guidance AGENCY: Federal Highway... Major Project Financial Plan Guidance outlining the procedures the FHWA will follow when reviewing and approving Financial Plans. The proposed Major Project Financial Plan Guidance incorporates changes required...

  16. Guidance law with impact time and impact angle constraints

    Institute of Scientific and Technical Information of China (English)

    Zhang Youan; Ma Guoxin; Liu Aili

    2013-01-01

    A novel closed-form guidance law with impact time and impact angle constraints is proposed for salvo attack of anti-ship missiles,which employs missile's normal acceleration (not jerk) as the control command directly.Firstly,the impact time control problem is formulated as tracking the designated time-to-go (the difference between the designated impact time and the current flight time) for the actual time-to-go of missile,and the impact angle control problem is formulated as tracking the designated heading angle for the actual heading angle of missile.Secondly,a biased proportional navigation guidance (BPNG) law with designated heading angle constraint is constructed,and the actual time-to-go estimation for this BPNG is derived analytically by solving the system differential equations.Thirdly,by adding a feedback control to this constructed BPNG to eliminate the time-to-go error-the difference between the standard time-to-go and the actual time-to-go,a guidance law with adjustable coefficients to control the impact time and impact angle simultaneously is developed.Finally,simulation results demonstrate the performance and feasibility of the proposed approach.

  17. International Conference on Harmonisation; guidance on Addendum to E2C Clinical Safety Data Management: Periodic Safety Update Reports for Marketed Drugs; availability. Notice.

    Science.gov (United States)

    2004-02-05

    The Food and Drug Administration (FDA) is announcing the availability of a guidance entitled "Addendum to E2C Clinical Safety Data Management: Periodic Safety Update Reports for Marketed Drugs" (the ICH E2C guidance). The guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). In the Federal Register of May 19, 1997 (62 FR 27470), FDA published the ICH E2C guidance, which recommends a unified standard for the format, content, and reporting frequency for postmarketing periodic safety update reports (PSURs) for drug and biological products. This guidance, an addendum to the ICH E2C guidance, provides additional information on the content and format of PSURs, including clarification of the objectives, general principles, and model for PSURs. This guidance is intended to help harmonize collection and submission of postmarketing clinical safety data.

  18. Guidance of magnetic space tug

    Science.gov (United States)

    Fabacher, Emilien; Lizy-Destrez, Stéphanie; Alazard, Daniel; Ankersen, Finn; Profizi, Alexandre

    2017-07-01

    Magnetic tugging of a target satellite without thrust capacity can be interesting in various contexts, as for example End-Of-Life management, or to complete launchers capabilities. The aim is to gradually modify the orbit of the target by constantly exerting on it a magnetic force. To do so, the chaser is assumed equipped with a steerable magnetic dipole, able to create both forces and torques on the magnetic torque rods carried by the target. The chaser is also supposed to carry electric thrusters, creating a continuous force which modifies the orbit of the whole formation composed of chaser and target. The relative motions of both satellites are derived, in order to assess the feasibility of such a concept. Relative configuration (attitudes and position) trajectories are derived, which are compliant with the dynamics, and enable the chaser to tug the target. Considering targets in Low Earth Orbit (LEO), the magnetic field of the Earth is taken into account, modeled by the International Geomagnetic Reference Field (IGRF). The position of the magnetic torque rod of the target may not be located at its center of mass. This lever-arm is taken into account in the dynamics. As for every Electro-Magnetic Formation Flight concept developed in the literature, satellites involved in magnetic tugging are constantly subjected to torques, created by the Earth magnetic field and by the magnetic fields created by the other satellites in the formation. In this study, the solution chosen to face this problem is to take into account the attitude equilibrium of the satellites early in the guidance phase, in order to avoid having to wave the dipole, as it is generally done. Promising results are presented for different types of orbit, showing that the concept could be feasible in many different scenarios.

  19. Significant Guidance Issued by the Federal Highway Administration

    Data.gov (United States)

    Department of Transportation — A list of Significant Guidance documents, which include guidance document disseminated to regulated entities or the general public that may reasonably be anticipated...

  20. Significant Guidance Issued by the Federal Aviation Administration

    Data.gov (United States)

    Department of Transportation — A list of Significant Guidance documents, which include guidance document disseminated to regulated entities or the general public that may reasonably be anticipated...

  1. Significant Guidance Issued by the Federal Transit Administration

    Data.gov (United States)

    Department of Transportation — A list of Significant Guidance documents, which include guidance document disseminated to regulated entities or the general public that may reasonably be anticipated...

  2. Significant Guidance Issued by the Federal Motor Carrier Safety Administration

    Data.gov (United States)

    Department of Transportation — A list of Significant Guidance documents, which include guidance document disseminated to regulated entities or the general public that may reasonably be anticipated...

  3. Fusion Guidance in Endovascular Peripheral Artery Interventions: A Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Sailer, Anna M., E-mail: anni.sailer@mumc.nl; Haan, Michiel W. de, E-mail: m.de.haan@mumc.nl; Graaf, Rick de, E-mail: r.de.graaf@mumc.nl; Zwam, Willem H. van, E-mail: w.van.zwam@mumc.nl [Maastricht University Medical Center, Department of Radiology (Netherlands); Schurink, Geert Willem H., E-mail: gwh.schurink@mumc.nl [Maastricht University Medical Center, Department of Surgery (Netherlands); Nelemans, Patricia J., E-mail: patty.nelemans@maastrichtuniversity.nl [Maastricht University Medical Centre, Department of Epidemiology (Netherlands); Wildberger, Joachim E., E-mail: j.wildberger@mumc.nl; Das, Marco, E-mail: m.das@mumc.nl [Maastricht University Medical Center, Department of Radiology (Netherlands)

    2015-04-15

    PurposeThis study was designed to evaluate the feasibility of endovascular guidance by means of live fluoroscopy fusion with magnetic resonance angiography (MRA) and computed tomography angiography (CTA).MethodsFusion guidance was evaluated in 20 endovascular peripheral artery interventions in 17 patients. Fifteen patients had received preinterventional diagnostic MRA and two patients had undergone CTA. Time for fluoroscopy with MRA/CTA coregistration was recorded. Feasibility of fusion guidance was evaluated according to the following criteria: for every procedure the executing interventional radiologists recorded whether 3D road-mapping provided added value (yes vs. no) and whether PTA and/or stenting could be performed relying on the fusion road-map without need for diagnostic contrast-enhanced angiogram series (CEAS) (yes vs. no). Precision of the fusion road-map was evaluated by recording maximum differences between the position of the vasculature on the virtual CTA/MRA images and conventional angiography.ResultsAverage time needed for image coregistration was 5 ± 2 min. Three-dimensional road-map added value was experienced in 15 procedures in 12 patients. In half of the patients (8/17), intervention was performed relying on the fusion road-map only, without diagnostic CEAS. In two patients, MRA roadmap showed a false-positive lesion. Excluding three patients with inordinate movements, mean difference in position of vasculature on angiography and MRA/CTA road-map was 1.86 ± 0.95 mm, implying that approximately 95 % of differences were between 0 and 3.72 mm (2 ± 1.96 standard deviation).ConclusionsFluoroscopy with MRA/CTA fusion guidance for peripheral artery interventions is feasible. By reducing the number of CEAS, this technology may contribute to enhance procedural safety.

  4. Integrated Entry Guidance for Reusable Launch Vehicle

    Institute of Scientific and Technical Information of China (English)

    NING Guo-dong; ZHANG Shu-guang; FANG Zhen-ping

    2007-01-01

    A method for the implementation of integrated three-degree-of-freedom constrained entry guidance for reusable launch vehicle is presented. Given any feasible entry conditions, terminal area energy management interface conditions, and the reference trajectory generated onboard then, the method can generate a longitudinal guidance profile rapidly, featuring linear quadratic regular method and a proportional-integral-derivative tracking law with time-varying gains, which satisfies all the entry corridor constraints and meets the requirements with high precision. Afterwards, by utilizing special features of crossrange parameter, establishing bank-reversal corridor,and determining bank-reversals according to dynamically adjusted method, the algorithm enables the lateral entry guidance system to fly a wide range of missions and provides reliable and good performance in the presence of significant aerodynamic modeling uncertainty.Fast trajectory guidance profiles and simulations with a reusable launch vehicle model for various missions and aerodynamic uncertainties are presented to demonstrate the capacity and reliability of this method.

  5. Optimal guidance for the space shuttle transition

    Science.gov (United States)

    Stengel, R. F.

    1974-01-01

    A guidance method for the space shuttle's transition from hypersonic entry to subsonic cruising flight is presented. The method evolves from a numerical trajectory optimization technique in which kinetic energy and total energy (per unit weight) replace velocity and time in the dynamic equations. This allows the open end-time problem to be transformed to one of fixed terminal energy. In its ultimate form, E-Guidance obtains energy balance (including dynamic-pressure-rate damping) and path length control by angle-of-attack modulation and cross-range control by roll angle modulation. The guidance functions also form the basis for a pilot display of instantaneous maneuver limits and destination. Numerical results illustrate the E-Guidance concept and the optimal trajectories on which it is based.

  6. RCRA Programmatic Information Policy and Guidance

    Data.gov (United States)

    U.S. Environmental Protection Agency — This asset includes program policy and guidance documents that are used by the EPA regions, states, tribes and private parties to implement the hazardous waste...

  7. Tests and Guidance: What Students Need.

    Science.gov (United States)

    Krumboltz, John D.

    1982-01-01

    Innovations in testing and guidance which can integrate assessment to facilitate learning, help develop practical wisdom in behavior, and correct students' faulty cognitions in career decisions are described. (CM)

  8. Beyond Black: An Alternative to Ethnocentric Guidance

    Science.gov (United States)

    Goldman, Robert C.

    1977-01-01

    This article is a clarification of the author's personal philosophy in the guidance and counseling of youth and adults, and clarification of commonalities that form the raison d'etre of all student personnel services. (Author)

  9. Much more than just another guidance document.

    Science.gov (United States)

    Kulkarni, K

    2016-11-01

    As a pediatric hematologist oncologist with clinical and research interests in thrombosis in high-risk pediatric populations, and also as a member of the ISTH Early Career Task Force, I had the opportunity to develop a guidance document on 'Thromboprophylaxis for central venous catheters in the pediatric population' for the 'Guidelines and Guidance Documents' committee. In this communication, I share my experiences to date; I discuss my excitement and initial success, the steep learning curve required to build research acumen, the lessons learnt, and the opportunities and challenges faced. My experience with preparing the guidance document was much more than writing 'just another guidance document'. © 2016 International Society on Thrombosis and Haemostasis.

  10. ROUTE PLAN DESIGNER FOR TRACTOR GUIDANCE SYSTEMS

    DEFF Research Database (Denmark)

    Sveistrup, Daniel; Jørgensen, Rasmus Nyholm; Green, Ole

    2010-01-01

    Earlier works have shown field trial designs to be very labor extensive, even when combining autoguidancesystems with conventional machinery.Designing routes for semi-automated systems in a controlled manner is both resource demandingand complicated. Different types of auto-guidance systems vary...... was outlined, it took less thanone hour entering the design into the software and generating the auto-guidance files.KeywordsGIS, Auto steering systems, plot trial design, full-scale field trials, Java...

  11. Ergonomic concerns with lightbar guidance displays.

    Science.gov (United States)

    Ima, C S; Mann, D D

    2004-05-01

    This article reviews some ergonomic factors associated with agricultural guidance displays. Any technology or management decision that improves the efficiency of an agricultural operation can be considered an aspect of precision farming. Agricultural guidance displays are one such tool because they help to reduce guidance error (i.e., skipping and overlapping of implements within the field), which result in improper application of crop inputs at increased cost. Although each of the guidance displays currently available functions using a different principle, their key objective is to communicate useful guidance information to the operator of the agricultural machine. The case with which the operator obtains the required information depends on a number of ergonomic factors, such as color perceptibility, flash rate, attentional demand, display size, viewing distance, and height of placement of the display in the cab. Ergonomics can be defined as the application of knowledge to create a safe, comfortable, and effective work environment. Consequently, it is critical to consider ergonomics when designing guidance displays or when locating a display in the tractor cab. Without considering ergonomics, it is unlikely that the efficiency of the human-machine system can be optimized.

  12. International Conference on Harmonisation; guidance on data elements for transmission of individual case safety reports; availability. Notice. Food and Drug Administration, HHS.

    Science.gov (United States)

    1998-01-15

    The Food and Drug Administration (FDA) is publishing a guidance entitled "E2B Data Elements for Transmission of Individual Case Safety Reports." The guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The guidance is intended to facilitate the standardization of the data elements for the transmission of individual case safety reports for both preapproval and postapproval reporting periods.

  13. China's High Performance Computer Standard Commission Established

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ China's High Performance Computer Standard Commission was established on March 28, 2007, under the guidance of the Science and Technology Bureau of the Ministry of Information Industry. It will prepare relevant professional standards on high performance computers to break through the monopoly in the field by foreign manufacturers and vendors.

  14. Helping Black Youths to Speak Standard English.

    Science.gov (United States)

    Reed, Daisy F.

    A work-study program was designed to provide black inner-city youths with instruction and guidance in skills needed in their current jobs, especially their ability to speak standard English. The program used the technique of modeling to arouse students' motivation to adopt standard spoken English. Research has shown that the use of a model will be…

  15. BOMOS: Management and development model for open standards

    NARCIS (Netherlands)

    Folmer, Erwin; Kajan, Ejub; Dorloff, Frank-Dieter; Bedini, Ivan

    2012-01-01

    E-Business standards, or standards for interoperability, are developed outside the traditional standard development organizations, often within industry specific domain organizations. These organizations need some guidance in how to develop and manage standards for their specific domain in order to

  16. The Development of a Lifelong Guidance System in Hungary

    Science.gov (United States)

    Watts, A. G.; Borbely-Pecze, Bors Tibor

    2011-01-01

    The development of a lifelong guidance system in Hungary Systematic work is currently being undertaken in Hungary to develop a lifelong guidance system, in line with principles outlined by leading international organisations. The origins of career guidance in Hungary, and the nature of the current career guidance system, are outlined. The main…

  17. The voice of users in adult career guidance

    DEFF Research Database (Denmark)

    Plant, Peter

    2012-01-01

    Is the voice of users heard in adult career guidance? Pan-Nordic Research shows that users are seen as recipients rather than agents i adult career guidance.......Is the voice of users heard in adult career guidance? Pan-Nordic Research shows that users are seen as recipients rather than agents i adult career guidance....

  18. Constituent Aspects of Workplace Guidance in Secondary VET

    Science.gov (United States)

    Swager, Robert; Klarus, Ruud; van Merriënboer, Jeroen J. G.; Nieuwenhuis, Loek F. M.

    2015-01-01

    Purpose: This paper aims to present an integrated model of workplace guidance to enhance awareness of what constitutes good guidance, to improve workplace guidance practices in vocational education and training. Design/methodology/approach: To identify constituent aspects of workplace guidance, a systematic search of Web of Science was conducted,…

  19. The voice of users in adult career guidance

    DEFF Research Database (Denmark)

    Plant, Peter

    2012-01-01

    Is the voice of users heard in adult career guidance? Pan-Nordic Research shows that users are seen as recipients rather than agents i adult career guidance.......Is the voice of users heard in adult career guidance? Pan-Nordic Research shows that users are seen as recipients rather than agents i adult career guidance....

  20. Non-Participation in Guidance: An Opportunity for Development?

    Science.gov (United States)

    Thomsen, Rie

    2014-01-01

    This article discusses how new opportunities for guidance can emerge from an analysis of the interplay between the participation (or lack of participation) of the individuals in career guidance, and the career guidance practitioner's response. The article suggests critical psychology as a framework for career guidance research and presents…

  1. The Development of a Lifelong Guidance System in Hungary

    Science.gov (United States)

    Watts, A. G.; Borbely-Pecze, Bors Tibor

    2011-01-01

    The development of a lifelong guidance system in Hungary Systematic work is currently being undertaken in Hungary to develop a lifelong guidance system, in line with principles outlined by leading international organisations. The origins of career guidance in Hungary, and the nature of the current career guidance system, are outlined. The main…

  2. SU-E-J-185: A Systematic Review of Breathing Guidance in Radiation Oncology and Radiology

    Energy Technology Data Exchange (ETDEWEB)

    Pollock, S; Keall, P [University of Sydney, Sydney (Australia); Keall, R [Hammond Care Palliative and Supportive Care Service, Sydney, NSW (Australia)

    2015-06-15

    Purpose: The advent of image-guided radiation therapy (IGRT) has led to dramatic improvements in the accuracy of treatment delivery in radiotherapy. Such advancements have highlighted the deleterious impact tumor motion can have on both image quality and radiation treatment delivery. One approach to reducing tumor motion is the use of breathing guidance systems during imaging and treatment. A review of such research had not yet been performed, it was therefore our aim to perform a systematic review of breathing guidance interventions within the fields of radiation oncology and radiology. Methods: Results of online database searches were filtered in accordance to a set of eligibility criteria. The search, filtration, and analysis of articles were conducted in accordance with the PRISMAStatement reporting standard (Preferred Reporting Items for Systematic reviews and Meta-Analyses) utilizing the PICOS approach (Participants, Intervention, Comparison, Outcome, Study design). Participants: Cancer patients, healthy volunteers. Intervention: Biofeedback breathing guidance systems. Comparison: No breathing guidance of the same breathing type. Outcome: Regularity of breathing signal and anatomic/tumor motion, medical image quality, radiation treatment margins and coverage, medical imaging and radiation treatment times. Study design: Quantitative and controlled prospective or retrospective trials. Results: The systematic search yielded a total of 479 articles, which were filtered down to 27 relevant articles in accordance to the eligibility criteria. The vast majority of investigated outcomes were significantly positively impacted by the use of breathing guidance; however, this was dependent upon the nature of the breathing guidance system and study design. In 25/27 studies significant improvements from the use of breathing guidance were observed. Conclusion: The results found here indicate that further clinical studies are warranted which quantify more comprehensively the

  3. Guidance and Control Software Project Data - Volume 4: Configuration Management and Quality Assurance Documents

    Science.gov (United States)

    Hayhurst, Kelly J. (Editor)

    2008-01-01

    The Guidance and Control Software (GCS) project was the last in a series of software reliability studies conducted at Langley Research Center between 1977 and 1994. The technical results of the GCS project were recorded after the experiment was completed. Some of the support documentation produced as part of the experiment, however, is serving an unexpected role far beyond its original project context. Some of the software used as part of the GCS project was developed to conform to the RTCA/DO-178B software standard, "Software Considerations in Airborne Systems and Equipment Certification," used in the civil aviation industry. That standard requires extensive documentation throughout the software development life cycle, including plans, software requirements, design and source code, verification cases and results, and configuration management and quality control data. The project documentation that includes this information is open for public scrutiny without the legal or safety implications associated with comparable data from an avionics manufacturer. This public availability has afforded an opportunity to use the GCS project documents for DO-178B training. This report provides a brief overview of the GCS project, describes the 4-volume set of documents and the role they are playing in training, and includes configuration management and quality assurance documents from the GCS project. Volume 4 contains six appendices: A. Software Accomplishment Summary for the Guidance and Control Software Project; B. Software Configuration Index for the Guidance and Control Software Project; C. Configuration Management Records for the Guidance and Control Software Project; D. Software Quality Assurance Records for the Guidance and Control Software Project; E. Problem Report for the Pluto Implementation of the Guidance and Control Software Project; and F. Support Documentation Change Reports for the Guidance and Control Software Project.

  4. Performance standard for dose Calibrator

    CERN Document Server

    Darmawati, S

    2002-01-01

    Dose calibrator is an instrument used in hospitals to determine the activity of radionuclide for nuclear medicine purposes. International Electrotechnical Commission (IEC) has published IEC 1303:1994 standard that can be used as guidance to test the performance of the instrument. This paper briefly describes content of the document,as well as explains the assessment that had been carried out to test the instrument accuracy in Indonesia through intercomparison measurement.Its is suggested that hospitals acquire a medical physicist to perform the test for its dose calibrator. The need for performance standard in the form of Indonesia Standard is also touched.

  5. 45 CFR 73.735-805 - Advice and guidance on conflicts matters.

    Science.gov (United States)

    2010-10-01

    ... STANDARDS OF CONDUCT Financial Interest § 73.735-805 Advice and guidance on conflicts matters. (a) Whenever... nature of the actual or apparent conflict of interest; and (4) Any other information that may be helpful... deputy ethics counselor will develop any additional information about the matter as necessary, and will...

  6. School Counselors Share Their Favorite Classroom Guidance Activities: Guide to Planning, Conducting, and Processing

    Science.gov (United States)

    DeLucia-Waack, J., Ed.; Mercurio, M., Ed.; Colvin, F., Ed.; Korta, S., Ed.; Maertin, K., Ed.; Martin, E., Ed.; Zawadski, L., Ed.

    2014-01-01

    In this book, practicing school counselors have provided more than 60 classroom guidance activities that are presented across the three major ASCA areas in the National Standards for Students: Academic Skills, Personal/Social Skills, and Career Development/College Preparation. Activities are designed to integrate the ASCA Model, Response to…

  7. Student Guidance and Attention to Diversity in the Processes of Quality Assurance in Higher Education

    Science.gov (United States)

    Ferreira, Camino; Vidal, Javier; Vieira, María José

    2014-01-01

    The main objective of this article is to analyse the importance given to student guidance and diversity in the standards and criteria used in the quality accreditation and evaluation processes in Europe and the US. Agencies selected in this study are the members of ENQA (European Association for Quality Assurance in Higher Education), EQAR…

  8. Launch flexibility using NLP guidance and remote wind sensing

    Science.gov (United States)

    Cramer, Evin J.; Bradt, Jerre E.; Hardtla, John W.

    1990-01-01

    This paper examines the use of lidar wind measurements in the implementation of a guidance strategy for a nonlinear programming (NLP) launch guidance algorithm. The NLP algorithm uses B-spline command function representation for flexibility in the design of the guidance steering commands. Using this algorithm, the guidance system solves a two-point boundary value problem at each guidance update. The specification of different boundary value problems at each guidance update provides flexibility that can be used in the design of the guidance strategy. The algorithm can use lidar wind measurements for on pad guidance retargeting and for load limiting guidance steering commands. Examples presented in the paper use simulated wind updates to correct wind induced final orbit errors and to adjust the guidance steering commands to limit the product of the dynamic pressure and angle-of-attack for launch vehicle load alleviation.

  9. Raising the Profile of Career Guidance: Educational and Vocational Guidance Practitioner

    Science.gov (United States)

    Hiebert, Bryan

    2009-01-01

    In 2007 the International Association for Educational and Vocational Guidance (IAEVG) launched the Educational and Vocational Guidance Practitioner credential (EVGP) as one means of formally acknowledging the knowledge, skills, and personal attributes that practitioners need in order to provide quality career development services to clients. This…

  10. Guidance Trade-off for Aerocapture Missions

    Science.gov (United States)

    Vernis, P.; Gelly, G.; Ferreira, E.; da Costa, R.; Ortega, G.

    In the very late 90's, EADS-ST began home funded studies on aerocapture problems. The objectives of these studies were at that time to prepare a possible cooperation within the NASA/Cnes MSR-Orbiter program by investigating this new orbital insertion technique studying different algorithmic solutions from a guidance point of view. According to these preliminary studies, EADS-ST was retained in 2002 by ESA to study insertion techniques such as aerocapture, aero-gravity assist or aerobraking techniques within the frame of Technological Research Program able to bring solutions to Aurora program. In the frame of the ATPE (Aeroassist Technologies for Planetary Exploration) TRP program, EADS-ST, led by Astrium-Gmbh (now part of EADS-ST), developed and implemented an efficient and simple guidance scheme able to cope with mission requirements for aerocapture on Mars, Venus or the Earth: the Feedback Trajectory Control, or FTC. The development of this guidance scheme was made according to a preliminary trade-off analysis using different guidance schemes. Among those ones was an original predictor-corrector guidance scheme, already analyzed within the frame of the MSR-O mission. But, the FTC algoritm was prefered because of its good results and high simplicity. This paper presents an upgrade of the original Apoapsis Predictor, or AP, with the improvement of its robustness woth respect to off-nomonal flight conditions and its process simplification. A new trade-off analysis is then detailed on a Mars Sample return mission.

  11. Measuring Integrated Socioemotional Guidance at School: Factor Structure and Reliability of the Socioemotional Guidance Questionnaire (SEG-Q)

    Science.gov (United States)

    Jacobs, Karen; Struyf, Elke

    2013-01-01

    Socioemotional guidance of students has recently become an integral part of education, however no instrument exists to measure integrated socioemotional guidance. This study therefore examines the factor structure and reliability of the Socioemotional Guidance Questionnaire. Psychometric properties of the Socioemotional Guidance Questionnaire and…

  12. 78 FR 48201 - Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2013-01; Guidance for...

    Science.gov (United States)

    2013-08-07

    ... COMMISSION Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2013-01; Guidance for... Lessons-Learned Project Directorate Interim Staff Guidance (JLD-ISG), JLD-ISG-2013-01, ``Guidance for... to http://www.nrc.gov/reading-rm/doc-collections/isg/japan-lessons-learned.html and refer to...

  13. Human Genetic Disorders of Axon Guidance

    Science.gov (United States)

    Engle, Elizabeth C.

    2010-01-01

    This article reviews symptoms and signs of aberrant axon connectivity in humans, and summarizes major human genetic disorders that result, or have been proposed to result, from defective axon guidance. These include corpus callosum agenesis, L1 syndrome, Joubert syndrome and related disorders, horizontal gaze palsy with progressive scoliosis, Kallmann syndrome, albinism, congenital fibrosis of the extraocular muscles type 1, Duane retraction syndrome, and pontine tegmental cap dysplasia. Genes mutated in these disorders can encode axon growth cone ligands and receptors, downstream signaling molecules, and axon transport motors, as well as proteins without currently recognized roles in axon guidance. Advances in neuroimaging and genetic techniques have the potential to rapidly expand this field, and it is feasible that axon guidance disorders will soon be recognized as a new and significant category of human neurodevelopmental disorders. PMID:20300212

  14. 75 FR 82095 - Purchase of Irrevocable Commitments Before Standard Termination

    Science.gov (United States)

    2010-12-29

    ... Doc No: 2010-32827] PENSION BENEFIT GUARANTY CORPORATION Purchase of Irrevocable Commitments Before... taking further regulatory action or providing specific guidance on purchase of irrevocable commitments... a request for public comment on purchase of irrevocable commitments before standard termination...

  15. Aerospace plane guidance using geometric control theory

    Science.gov (United States)

    Van Buren, Mark A.; Mease, Kenneth D.

    1990-01-01

    A reduced-order method employing decomposition, based on time-scale separation, of the 4-D state space in a 2-D slow manifold and a family of 2-D fast manifolds is shown to provide an excellent approximation to the full-order minimum-fuel ascent trajectory. Near-optimal guidance is obtained by tracking the reduced-order trajectory. The tracking problem is solved as regulation problems on the family of fast manifolds, using the exact linearization methodology from nonlinear geometric control theory. The validity of the overall guidance approach is indicated by simulation.

  16. Active evacuation guidance using sensor agent robot

    Science.gov (United States)

    Ise, Daiki; Mita, Akira

    2012-04-01

    Evacuation systems for buildings are designed based on event scenarios, so they are not prepared for unexpected events that are not included in the scenarios. In this paper, we propose a new active evacuation guidance system using sensor agent robots. We first introduce a Structural Health Monitoring (SHM) system to be used in conjunction with sensor agent robots for active evacuation guidance. Then the role of sensor agent robots is explained. An algorithm to immediately access the safety of the building after a large earthquake is also proposed using only the information taken by a sensor agent robot.

  17. Virtual Ultrasound Guidance for Inexperienced Operators

    Science.gov (United States)

    Caine, Timothy; Martin, David

    2012-01-01

    Medical ultrasound or echocardiographic studies are highly operator-dependent and generally require lengthy training and internship to perfect. To obtain quality echocardiographic images in remote environments, such as on-orbit, remote guidance of studies has been employed. This technique involves minimal training for the user, coupled with remote guidance from an expert. When real-time communication or expert guidance is not available, a more autonomous system of guiding an inexperienced operator through an ultrasound study is needed. One example would be missions beyond low Earth orbit in which the time delay inherent with communication will make remote guidance impractical. The Virtual Ultrasound Guidance system is a combination of hardware and software. The hardware portion includes, but is not limited to, video glasses that allow hands-free, full-screen viewing. The glasses also allow the operator a substantial field of view below the glasses to view and operate the ultrasound system. The software is a comprehensive video program designed to guide an inexperienced operator through a detailed ultrasound or echocardiographic study without extensive training or guidance from the ground. The program contains a detailed description using video and audio to demonstrate equipment controls, ergonomics of scanning, study protocol, and scanning guidance, including recovery from sub-optimal images. The components used in the initial validation of the system include an Apple iPod Classic third-generation as the video source, and Myvue video glasses. Initially, the program prompts the operator to power-up the ultrasound and position the patient. The operator would put on the video glasses and attach them to the video source. After turning on both devices and the ultrasound system, the audio-video guidance would then instruct on patient positioning and scanning techniques. A detailed scanning protocol follows with descriptions and reference video of each view along with

  18. Autonomous gliding entry guidance with geographic constraints

    Institute of Scientific and Technical Information of China (English)

    Guo Jie; Wu Xuzhong; Tang Shengjing

    2015-01-01

    This paper presents a novel three-dimensional autonomous entry guidance for relatively high lift-to-drag ratio vehicles satisfying geographic constraints and other path constraints. The guidance is composed of onboard trajectory planning and robust trajectory tracking. For trajectory planning, a longitudinal sub-planner is introduced to generate a feasible drag-versus-energy profile by using the interpolation between upper boundary and lower boundary of entry corridor to get the desired trajectory length. The associated magnitude of the bank angle can be specified by drag profile, while the sign of bank angle is determined by lateral sub-planner. Two-reverse mode is utilized to satisfy waypoint constraints and dynamic heading error corridor is utilized to satisfy no-fly zone constraints. The longitudinal and lateral sub-planners are iteratively employed until all of the path constraints are satisfied. For trajectory tracking, a novel tracking law based on the active disturbance rejection control is introduced. Finally, adaptability tests and Monte Carlo simulations of the entry guidance approach are performed. Results show that the proposed entry guidance approach can adapt to different entry missions and is able to make the vehicle reach the prescribed target point precisely in spite of geographic constraints.

  19. Guidance for performing site inspections under CERCLA

    Energy Technology Data Exchange (ETDEWEB)

    1992-09-01

    This guidance presents EPA`s site inspection (SI) strategy. The strategy discusses procedural guidelines to investigate potential Superfund (CERCLA) sites for evaluation pursuant to the Hazard Ranking System (HRS), revised in accordance with the Superfund Amendments and Reauthorization Act of 1986. The HRS is the primary means by which EPA evaluates sites for superfund`s National Priorities List (NPL).

  20. Cannabinoid receptor CB2 modulates axon guidance

    DEFF Research Database (Denmark)

    Duff, Gabriel; Argaw, Anteneh; Cecyre, Bruno

    2013-01-01

    Navigation of retinal projections towards their targets is regulated by guidance molecules and growth cone transduction mechanisms. Here, we present in vitro and in vivo evidences that the cannabinoid receptor 2 (CB2R) is expressed along the retino-thalamic pathway and exerts a modulatory action ...

  1. Hypermedia Authoring with Writing Process Guidance

    Science.gov (United States)

    Chang, Kuo-En; Sung, Yao-Ting; Zheng, Jie-Wen

    2007-01-01

    A writing process of five stages, setting the topic and goals, planning the outline, organising the structure, building the content, and reviewing, is proposed to guide hypermedia authoring. To explore the effects of the system designed with writing-process guidance, this study enrolled 108 seventh graders at a junior high school as experimental…

  2. guidance and behaviour management in early childhood

    African Journals Online (AJOL)

    Elizabeth

    development and the general behaviour manifestation of children under the childcare ... given by care givers to infants in the pre-primary school classes). Guidance means an .... aids, such as films, recorders, video, TV., children play; ... Simulation and games: These are teaching techniques in which real life situations and ...

  3. MR Thermometry for guidance of thermal therapy

    NARCIS (Netherlands)

    Sprinkhuizen, S.M.

    2010-01-01

    The research described in this thesis has aimed to further investigate magnetic resonance (MR) thermometry (MRT) techniques as to become a reliable guidance tool for thermal therapy. The various physical processes allowing for temperature measurements based upon the MR signal are described. It is de

  4. The Guidance Counselor and the Reading Curriculum.

    Science.gov (United States)

    Ediger, Marlow

    There are many ways guidance counselors can help teachers achieve more optimal reading instruction. Counselors first may have to ascertain the kinds of problems faced by a student in learning to read. Assessing a student's ability to use picture clues to decipher words may be necessary with primary grade students. Knowledge about phonics, using…

  5. Museum Personnel's Opinions on Mobile Guidance Systems

    Science.gov (United States)

    Yoshimura, Hirokazu; Sekiguchi, Hiromi; Yabumoto, Yoshitaka

    2007-01-01

    While opinions from the general public are certainly important, opinions from the museum staff are also necessary to improve user service systems. this article introduces two groups of museum staff who have evaluated the usability of mobile guidance systems in Japanese museums. One group is the research team who used the PDA system in the National…

  6. 33 CFR 385.5 - Guidance memoranda.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Guidance memoranda. 385.5 Section 385.5 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE PROGRAMMATIC REGULATIONS FOR THE COMPREHENSIVE EVERGLADES RESTORATION PLAN General...

  7. Epilepsy in the Classroom: Guidance for Educators.

    Science.gov (United States)

    Lassner, Lee M.

    This paper for educators, school psychologists, and counselors attempts to provide guidance for meeting the needs of students with epilepsy. Stressed throughout the paper are ways to provide for the child's special needs while fostering his/her self esteem and full participation in classroom activities. The paper addresses the following topics:…

  8. "Telling Tales": Using Narrative in Career Guidance

    Science.gov (United States)

    Reid, Hazel; West, Linden

    2011-01-01

    In this article the authors argue for the importance of narrative-based approaches in career guidance work in an uncertain, unpredictable world. This requires a paradigmatic shift in thinking that can be too difficult, at present, for some practitioners. The article reports on the first phase of a collaborative project with a group of…

  9. A Leading Role for Career Guidance Counselors

    Science.gov (United States)

    Reese, Susan

    2010-01-01

    Without structured guidance activities, students may drift through high school without learning about all of the career opportunities available and without gaining the skills that can help them take advantage of those opportunities. They may also be in danger of failing to continue on to postsecondary education, or even worse, of dropping out of…

  10. Effective Child Guidance: An Educator's Guidebook.

    Science.gov (United States)

    Hill, Brent Mathews

    This guidebook is designed to assist educators in becoming more effective child guidance leaders within the school system. Sections discuss the following areas: (1) indicators of current emotional problems; (2) children's common emotional problems, including fears, separation and loss, misbehavior motivations, aggressiveness, stealing, lying,…

  11. Athletics Guidance Aims for Level Field

    Science.gov (United States)

    Samuels, Christina A.

    2013-01-01

    A document from the U.S. Department of Education intended to clarify schools' responsibility to make sure students with disabilities have access to extracurricular sports has drawn sharply different opinions. Disability-rights advocates welcome the guidance, while critics say federal officials are pushing requirements that could place new…

  12. X-ray tomographic intervention guidance: Towards real-time 4D imaging

    CERN Document Server

    Bartling, Sönke

    2016-01-01

    Implementation of real-time, continuous, and three-dimensional imaging (4D intervention guidance) would be a quantum leap for minimally-invasive medicine. It allows guidance during interventions by assessing the spatial position of instruments continuously in respect to their surroundings. Recent research showed that it is feasible using X-ray and novel tomographic reconstruction approaches. Radiation dose stays within reasonable limits. This article provides abstractions and background information together with an outlook on these prospects. There are explanations of how situational awareness during interventions is generated today and how they will be in future. The differences between fluoroscopically and CT-guided interventions are eluted to within the context of these developments. The exploration of uncharted terrain between these current methods is worth pursuing. Necessary image quality of 4D intervention guidance varies relevantly from that of standard computed tomography. Means to analyze the risk-b...

  13. International Conference on Harmonisation; Guidance on E2F Development Safety Update Report; availability. Notice.

    Science.gov (United States)

    2011-08-23

    The Food and Drug Administration (FDA) is announcing the availability of a guidance entitled "E2F Development Safety Update Report." The guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The guidance describes the format, content, and timing of a development safety update report (DSUR) for an investigational drug. The DSUR will serve as a common standard for periodic reporting on drugs under development (including marketed drugs that are under further study) among the ICH regions. The DSUR can be submitted in the United States in place of an annual report for an investigational new drug application (IND). The harmonized DSUR is intended to promote a consistent approach to annual clinical safety reporting among the ICH regions and enhance efficiency by reducing the number of reports generated for submission to the regulatory authorities.

  14. International Conference on Harmonisation; draft guidance on E2F Development Safety Update Report; availability. Notice.

    Science.gov (United States)

    2008-08-05

    The Food and Drug Administration (FDA) is announcing the availability of a draft guidance entitled "E2F Development Safety Update Report." The draft guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The draft guidance describes the format, content, and timing of a development safety update report (DSUR) for an investigational drug. The DSUR would serve as a harmonized, annual clinical trial safety report that would be standard among the three ICH regions. The DSUR could be submitted in the United States in place of an annual report for an investigational new drug application (IND). The harmonized DSUR is intended to promote a consistent approach to annual clinical safety reporting among the ICH regions and enhance efficiency by reducing the number of reports generated for submission to the regulatory authorities.

  15. Advances in spacecraft atmospheric entry guidance

    Science.gov (United States)

    Benito Manrique, Joel

    In order to advance entry guidance technology two different research areas have been explored with the objective of increasing the reachable landing area and the landing accuracy for future Mars missions. Currently only the northern hemisphere of Mars is available for landing due to its low elevation. Only low elevation landing sites have the necessary atmospheric density to allow landing using current Entry, Descent and Landing (EDL) technology. In order to reach most of the Ancient Highlands, the majority of the southern hemisphere, advanced EDL technology is needed in multiple fields, including entry guidance. The first research area is the definition and applications of reachable and controllable sets for entry. The definition of the reachable and controllable sets provides a framework for the study of the capabilities of an entry vehicle in a given planet. Reachable and controllable sets can be used to comprehensively characterize the envelope of trajectories that a vehicle can fly, the sites it can reach and the entry states that can be accommodated. The sets can also be used for the evaluation of trajectory planning algorithms and to assist in the selection of the entry or landing sites. In essence, the reachable and controllable sets offer a powerful vehicle and trajectory analysis and design framework that allows for better mission design choices. In order to illustrate the use of the sets, they are computed for a representative Mars mission using two different vehicle configurations. The sets characterize the impact of the vehicle configuration on the entry capability. Furthermore, the sets are used to find the best skip-entry trajectory for a return from the Moon mission, highlighting the utility of the sets in atmospheric maneuvers other than entry. The second research area is the development of the components of an entry guidance algorithm that allow high elevation landing and provide as well high landing accuracy. The approach taken follows the

  16. Guidance for laboratories performing molecular pathology for cancer patients.

    Science.gov (United States)

    Cree, Ian A; Deans, Zandra; Ligtenberg, Marjolijn J L; Normanno, Nicola; Edsjö, Anders; Rouleau, Etienne; Solé, Francesc; Thunnissen, Erik; Timens, Wim; Schuuring, Ed; Dequeker, Elisabeth; Murray, Samuel; Dietel, Manfred; Groenen, Patricia; Van Krieken, J Han

    2014-11-01

    Molecular testing is becoming an important part of the diagnosis of any patient with cancer. The challenge to laboratories is to meet this need, using reliable methods and processes to ensure that patients receive a timely and accurate report on which their treatment will be based. The aim of this paper is to provide minimum requirements for the management of molecular pathology laboratories. This general guidance should be augmented by the specific guidance available for different tumour types and tests. Preanalytical considerations are important, and careful consideration of the way in which specimens are obtained and reach the laboratory is necessary. Sample receipt and handling follow standard operating procedures, but some alterations may be necessary if molecular testing is to be performed, for instance to control tissue fixation. DNA and RNA extraction can be standardised and should be checked for quality and quantity of output on a regular basis. The choice of analytical method(s) depends on clinical requirements, desired turnaround time, and expertise available. Internal quality control, regular internal audit of the whole testing process, laboratory accreditation, and continual participation in external quality assessment schemes are prerequisites for delivery of a reliable service. A molecular pathology report should accurately convey the information the clinician needs to treat the patient with sufficient information to allow for correct interpretation of the result. Molecular pathology is developing rapidly, and further detailed evidence-based recommendations are required for many of the topics covered here.

  17. Safety guidance and inspection program for particle accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Do Whey [Korea Institute of Nuclear Safety, Taejon (Korea, Republic of); Lee, Hee Seock; Yeo, In Whan [Pohang Accelerator Laboratory, Pohang (Korea, Republic of)] (and others)

    2001-03-15

    The inspection program and the safety guidance were developed to enhance the radiation protection for the use of particle accelerators. First the classification of particle accelerators was conducted to develop the safety inspection protocol efficiently. The status of particle accelerators which were operated at the inside and outside of the country, and their safety programs were surveyed. The characteristics of radiation production was researched for each type of particle accelerators. Two research teams were launched for industrial and research accelerators and for medical accelerators, respectively. In each stages of a design, a fabrication, an installation, a commissioning, and normal operation of accelerators, those safety inspection protocols were developed. Because all protocols resulted from employing safety experts, doing the questionnaire, and direct facility surveys, it can be applicable to present safety problem directly. The detail improvement concepts were proposed to revise the domestic safety rule. This results might also be useful as a practical guidance for the radiation safety officer of an accelerator facility, and as the detail standard for the governmental inspection authorities.

  18. 76 FR 66057 - North American Electric Reliability Corporation; Order Approving Regional Reliability Standard

    Science.gov (United States)

    2011-10-25

    ... Reliability Standard PRC-002-NPCC- 01, and NPCC's guidance establishes maintenance and testing expectations... Energy Regulatory Commission 61,043] North American Electric Reliability Corporation; Order Approving Regional Reliability Standard Issued October 20, 2011. Before Commissioners: Jon Wellinghoff, Chairman...

  19. 77 FR 25721 - Small Entity Compliance Guide: Bottled Water: Quality Standard: Establishing an Allowable Level...

    Science.gov (United States)

    2012-05-01

    ... HUMAN SERVICES Food and Drug Administration Small Entity Compliance Guide: Bottled Water: Quality... availability of a guidance for industry entitled ``Bottled Water: Quality Standard: Establishing an Allowable... its bottled water standard of quality regulations by establishing an allowable level for...

  20. A Formal Investigation of the Organization of Guidance Behavior: Implications for Humans and Autonomous Guidance

    Science.gov (United States)

    Kong, Zhaodan

    Guidance behavior generated either by artificial agents or humans has been actively studied in the fields of both robotics and cognitive science. The goals of these two fields are different. The former is the automatic generation of appropriate or even optimal behavior, while the latter is the understanding of the underlying mechanism. Their challenges, though, are closely related, the most important one being the lack of a unified, formal and grounded framework where the guidance behavior can be modeled and studied. This dissertation presents such a framework. In this framework, guidance behavior is analyzed as the closed-loop dynamics of the whole agent-environment system. The resulting dynamics give rise to interaction patterns. The central points of this dissertation are that: first of all, these patterns, which can be explained in terms of symmetries that are inherent to the guidance behavior, provide building blocks for the organization of behavior; second, the existence of these patterns and humans' organization of their guidance behavior based on these patterns are the reasons that humans can generate successful behavior in spite of all the complexities involved in the planning and control. This dissertation first gives an overview of the challenges existing in both scientific endeavors, such as human and animal spatial behavior study, and engineering endeavors, such as autonomous guidance system design. It then lays out the foundation for our formal framework, which states that guidance behavior should be interpreted as the collection of the closed-loop dynamics resulting from the agent's interaction with the environment. The following, illustrated by examples of three different UAVs, shows that the study of the closed-loop dynamics should not be done without the consideration of vehicle dynamics, as is the common practice in some of the studies in both autonomous guidance and human behavior analysis. The framework, the core concepts of which are

  1. Downstream of guidance receptors: entering the baroque period of axon guidance signaling.

    Science.gov (United States)

    Schmucker, Dietmar

    2003-09-25

    The Roundabout ("Robo") family of transmembrane proteins are the receptors and mediators of the repellent axon guidance signal Slit. However, the molecular mechanisms by which Robo signaling leads to growth cone or neuron repulsion are still poorly understood. A study by Fan et al. in this issue of Neuron expands the repertoire of Robo pathway components and stimulates a new look at axon guidance signaling in general.

  2. 78 FR 4848 - Social Media: Consumer Compliance Risk Management Guidance

    Science.gov (United States)

    2013-01-23

    ... more interactive. Financial institutions may use social media in a variety of ways, including marketing... INSTITUTIONS EXAMINATION COUNCIL Social Media: Consumer Compliance Risk Management Guidance AGENCY: Federal... this proposed guidance entitled ``Social Media: Consumer Compliance Risk Management...

  3. 75 FR 48973 - Draft Guidance for Industry: Prevention of Salmonella

    Science.gov (United States)

    2010-08-12

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry: Prevention of Salmonella... availability of a draft guidance entitled ``Prevention of Salmonella Enteritidis in Shell Eggs During... ``Prevention of Salmonella Enteritidis in Shell Eggs During Production, Storage, and Transportation''...

  4. Guidance for the verification and validation of neural networks

    CERN Document Server

    Pullum, L; Darrah, M

    2007-01-01

    Guidance for the Verification and Validation of Neural Networks is a supplement to the IEEE Standard for Software Verification and Validation, IEEE Std 1012-1998. Born out of a need by the National Aeronautics and Space Administration's safety- and mission-critical research, this book compiles over five years of applied research and development efforts. It is intended to assist the performance of verification and validation (V&V) activities on adaptive software systems, with emphasis given to neural network systems. The book discusses some of the difficulties with trying to assure adaptive systems in general, presents techniques and advice for the V&V practitioner confronted with such a task, and based on a neural network case study, identifies specific tasking and recommendations for the V&V of neural network systems.

  5. Evaluation of the Usefulness of the Respiratory Guidance System in the Respiratory Gating Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yeong Cheol; Kim, Sun Myung; Do, Gyeong Min; Park, Geun Yong; Kim, Gun Oh; Kim, Young Bum [Dept. of Radiation Oncology, Guro Hospital, Korea Univeristy, Seoul (Korea, Republic of)

    2012-09-15

    The respiration is one of the most important factors in respiratory gating radiation therapy (RGRT). We have developed an unique respiratory guidance system using an audio-visual system in order to support and stabilize individual patient's respiration and evaluated the usefulness of this system. Seven patients received the RGRT at our clinic from June 2011 to April 2012. After breathing exercise standard deviations by the superficial contents of respiratory cycles and functions, and analyzed them to examine changes in their breathing before and with the audio-visual system, we measured their spontaneous respiration and their respiration with the audio-visual system respectively. With the measured data, we yielded after the therapy. The PTP (peak to peak) of the standard deviations of the free breathing, the audio guidance system, and the respiratory guidance system were 0.343, 0.148, and 0.078 respectively. The respiratory cycles were 0.645, 0.345, and 0.171 respectively and the superficial contents of the respiratory functions were 2.591, 1.008, and 0.877 respectively. The average values of the differences in the standard deviations among the whole patients at the CT room and therapy room were 0.425 for the PTP, 1.566 for the respiratory cycles, and 3.671 for the respiratory superficial contents. As for the standard deviations before and after the application of the PTP respiratory guidance system, that of the PTP was 0.265, that of the respiratory cycles was 0.474, and that of the respiratory superficial contents. The results of t-test of the values before and after free breathing and the audio-visual guidance system showed that the P-value of the PTP was 0.035, that of the cycles 0.009, and that of the respiratory superficial contents 0.010. The respiratory control could be one of the most important factors in the RGRT which determines the success or failure of a treatment. We were able to get more stable breathing with the audio-visual respiratory

  6. [Auditory guidance systems for the visually impaired people].

    Science.gov (United States)

    He, Jing; Nie, Min; Luo, Lan; Tong, Shanbao; Niu, Jinhai; Zhu, Yisheng

    2010-04-01

    Visually impaired people face many inconveniences because of the loss of vision. Therefore, scientists are trying to design various guidance systems for improving the lives of the blind. Based on sensory substitution, auditory guidance has become an interesting topic in the field of biomedical engineering. In this paper, we made a state-of-technique review of the auditory guidance system. Although there have been many technical challenges, the auditory guidance system would be a useful alternative for the visually impaired people.

  7. Effect of Autopilot Structure on Proportional Navigation Guidance

    Institute of Scientific and Technical Information of China (English)

    XIA Qun-li; LIU Yi-ying; QI Zai-kang

    2007-01-01

    The dynamic characteristics of acceleration autopilot and attitude autopilot are discussed in detail.Also, a comparison study was made between these two different types of control schemes for guidance loop.By means of simulation, it is concluded that the guidance accuracy is mainly determined by the slowest subsystem among different system dynamics.For air-to-ground missiles, with limited terminal guidance time, the control scheme of acceleration autopilot combined with proportional navigation guidance (PNG) law is the better choice.

  8. Integrated guidance and control design for missile with terminal impact angle constraint based on sliding mode control

    Institute of Scientific and Technical Information of China (English)

    Peng Wu; Ming Yang

    2010-01-01

    Aimed at the guidance requirements of some missiles which attack targets with terminal impact angle at the terminal point,a new integrated guidance and control design scheme based on variable structure control approach for missile with terminal impact angle constraint is proposed.First,a mathematical model of an integrated guidance and control model in pitch plane is established,and then nonlinear transformation is employed to transform the mathematical model into a standard form suitable for sliding mode control method design.A sufficient condition for the existence of linear sliding surface is given in terms of linear matrix inequalities(LMIs),based on which the corresponding reaching motion controller is also developed.To verify the effectiveness of the proposed integrated design scheme,the numerical simulation of missile is made.The simulation results demonstrate that the proposed guidance and control law can guide missile to hit the target with desired impact angle and desired flight attitude angle simultaneously.

  9. ['Gold standard', not 'golden standard'

    NARCIS (Netherlands)

    Claassen, J.A.H.R.

    2005-01-01

    In medical literature, both 'gold standard' and 'golden standard' are employed to describe a reference test used for comparison with a novel method. The term 'gold standard' in its current sense in medical research was coined by Rudd in 1979, in reference to the monetary gold standard. In the same w

  10. ['Gold standard', not 'golden standard'

    NARCIS (Netherlands)

    Claassen, J.A.H.R.

    2005-01-01

    In medical literature, both 'gold standard' and 'golden standard' are employed to describe a reference test used for comparison with a novel method. The term 'gold standard' in its current sense in medical research was coined by Rudd in 1979, in reference to the monetary gold standard. In the same

  11. 2 CFR 182.40 - How is the guidance maintained?

    Science.gov (United States)

    2010-01-01

    ... AND AGREEMENTS Reserved GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) § 182.40 How is the guidance maintained? The OMB publishes proposed changes to the guidance in the... groups, and then issues any changes to the guidance in final form. ...

  12. Acid rain compliance: The need for regulatory guidance

    Energy Technology Data Exchange (ETDEWEB)

    Solomon, B.D. [Environmental Protection Agency, Washington, DC (United States)

    1993-07-01

    This article presents a broad view of the need for regulatory guidance when confronting the problem of acid rain. The two major topics addressed are (1) Why is guidance needed and (2) What kind of guidance is needed. Discussion of rate and accounting treatment of allowances, acid rain compliance planning, and allowance trading and energy efficiency are included.

  13. 76 FR 75771 - Emergency Planning Guidance for Nuclear Power Plants

    Science.gov (United States)

    2011-12-05

    ... Part 52 RIN 3150-AI10 Emergency Planning Guidance for Nuclear Power Plants AGENCY: Nuclear Regulatory... Regulatory Commission (NRC) is issuing Supplement 3, ``Guidance for Protective Action Strategies,'' to NUREG... Guidance Emergency Planning for Nuclear Power Plants;'' and NUREG/CR-7002, ``Criteria for Development of...

  14. Managing Student Behavior during Large Group Guidance: What Works Best?

    Science.gov (United States)

    Quarto, Christopher J.

    2007-01-01

    Participants provided information pertaining to managing non-task-related behavior of students during large group guidance lessons. In particular, school counselors were asked often how often they provide large group guidance, the frequency of which students exhibit off-task and/or disruptive behavior during guidance lessons, and techniques they…

  15. Tobaccofree Sports Stadia: European Policies and Guidance

    Directory of Open Access Journals (Sweden)

    Matthew Philpott

    2016-03-01

    Full Text Available Over 20 million people – including many children and young people - attend professional football matches across Europe each week, with many more attending other professional and amateur sports fixtures. The vast majority of European sports venues take place in semi-enclosed structures with roofed stands, and yet there are still very low levels of smokefree and tobaccofree policies in operation. Building on research findings that only 10 out of UEFA’s 54 European countries have football stadia that operate tobaccofree policies, Healthy Stadia has worked with UEFA and World Heart Federation to develop new guidance materials for clubs, multi-purpose stadium operators and governing bodies of sport to assist in the development and enforcement of strong tobacco control policies. This presentation will give a benchmark of current policies in place, support offered through the new guidance materials, and advice on how sports organisations can go beyond national tobacco control legislation to implement tobaccofree policies.

  16. ROUTE PLAN DESIGNER FOR TRACTOR GUIDANCE SYSTEMS

    DEFF Research Database (Denmark)

    Sveistrup, Daniel; Jørgensen, Rasmus Nyholm; Green, Ole

    2010-01-01

    Earlier works have shown field trial designs to be very labor extensive, even when combining autoguidancesystems with conventional machinery.Designing routes for semi-automated systems in a controlled manner is both resource demandingand complicated. Different types of auto-guidance systems vary....... The software works in conjunction with Google Earth to import field boundaries,and for viewing, validating and georeferencing completed field trial designs. The software isplatform independent and online distributed by means of the Java development environment.Two case studies were applied for demonstrating...... was outlined, it took less thanone hour entering the design into the software and generating the auto-guidance files.KeywordsGIS, Auto steering systems, plot trial design, full-scale field trials, Java...

  17. Practical guidance on undertaking a service evaluation.

    Science.gov (United States)

    Moule, Pam; Armoogum, Julie; Dodd, Emily; Donskoy, Anne-Laure; Douglass, Emma; Taylor, Julie; Turton, Pat

    2016-07-06

    This article describes the basic principles of evaluation, focusing on the evaluation of healthcare services. It emphasises the importance of evaluation in the current healthcare environment and the requirement for nurses to understand the essential principles of evaluation. Evaluation is defined in contrast to audit and research, and the main theoretical approaches to evaluation are outlined, providing insights into the different types of evaluation that may be undertaken. The essential features of preparing for an evaluation are considered, and guidance provided on working ethically in the NHS. It is important to involve patients and the public in evaluation activity, offering essential guidance and principles of best practice. The authors discuss the main challenges of undertaking evaluations and offer recommendations to address these, drawing on their experience as evaluators.

  18. [Problems of reception in a guidance center].

    Science.gov (United States)

    Mattelaer, P

    1975-01-01

    The aim of this communication is not to criticise the work of guidance, but to analyse its efficiency and validity in order to formulate concrete proposals. One can distinguish three periods in the evolution of the work in a guidance center. In the first period, it is a methodological concern which presided to this type of work. In the second period, one thought that there was to many preliminary investigations and it was decided to take the child in treatment more rapidly. During the third period, the attention has primarily be centered on the child's problems. The author suggests some solutions. He considers it is necessary to abandon the multidisciplinary approach. He advises to always consider one case at the time within a therapeutic and diagnostic frame. Therapy has to be conducted by one person, even if this person has to treat the whole family.

  19. Guidance for UMTRA project surveillance and maintenance

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-01-01

    The Guidance for UMTRA Project Surveillance and Maintenance describes the procedures that will be used to verify that Uranium Mill Tailings Remedial Action (UMTRA) Project disposal sites continue to function as designed. The approach of this guidance document is to identify surveillance requirements and maintenance procedures that will be used to comply with NRC license requirements. This document addresses five primary activities: Definition and characterization of final site conditions. Site inspections; Ground-water monitoring; Aerial photography; and Custodial maintenance and contingency repair. Final site conditions will be defined and characterized prior to the completion of remedial actions at a site. As-built drawings will be compiled, a final topographic survey will be performed, a vicinity map will be prepared, and ground and aerial photographs will be taken. Survey monuments, site markers, and signs will be established as will a network of monitoring wells.

  20. GUIDANCE DOCUMENT ON IMPLEMENTATION OF THE ...

    Science.gov (United States)

    The Agreement in Principle for the Stage 2 M-DBP Federal Advisory Committee contains a list of treatment processes and management practices for water systems to use in meeting additional Cryptosporidium treatment requirements under the LT2ESWTR. This list, termed the microbial toolbox, includes watershed control programs, alternative intake locations, pretreatment processes, additional filtration barriers, inactivation technologies, and enhanced plant performance. The intent of the microbial toolbox is to provide water systems with broad flexibility in selecting cost-effective LT2ESWTR compliance strategies. Moreover, the toolbox allows systems that currently provide additional pathogen barriers or that can demonstrate enhanced performance to receive additional Cryptosporidium treatment credit. Provide guidance to utilities with surface water supplies and to state drinking water programs on the use of different treatment technologies to reduce the level of Cryptosporidium in drinking water. Technologies included in the guidance manual may be used to achieve compliance with the requirements of the LT2ESWTR.

  1. Taxonometric guidance for developing quality assurance.

    Science.gov (United States)

    Thomadsen, Bruce; Lin, She-Woei

    2008-01-01

    A taxonomy is an ordered classification system. In error reduction analysis, an examination of the human failures that lead to an event often uses a taxonomy to classify the failures according to some aspect of their characteristics. These classifications provide insights into the forces that kept the persons involved from achieving their intended actions. They also can provide guidance for changing the situation to prevent failure in the future. For example, the corrective action would be different if a therapist pressed the wrong button because several buttons looked alike or they forgot which button to press. Different types of failures lead to particular types of remediation. Taxonomies can provide guidance in selecting between possible corrective actions.

  2. 76 FR 43690 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

    Science.gov (United States)

    2011-07-21

    ... HUMAN SERVICES Food and Drug Administration (Formerly 2007D-0309) Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance Document: Electrocardiograph Electrodes; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and...

  3. 75 FR 54637 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

    Science.gov (United States)

    2010-09-08

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance Document for Certain Percutaneous Transluminal Coronary Angioplasty (PTCA) Catheters; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY:...

  4. Pollution Control Guidance for Geothermal Energy Development

    Energy Technology Data Exchange (ETDEWEB)

    Hartley, Robert P.

    1978-06-01

    This report summarizes the EPA regulatory approach toward geothermal energy development. The state of knowledge is described with respect to the constituents of geothermal effluents and emissions, including water, air, solid wastes, and noise. Pollutant effects are discussed. Pollution control technologies that may be applicable are described along with preliminary cost estimates for their application. Finally discharge and emission limitations are suggested that may serve as interim guidance for pollution control during early geothermal development.

  5. Orbital maneuvering vehicle guidance, navigation and control

    Science.gov (United States)

    Huber, W. G.; Finnell, W., III

    1985-01-01

    This paper describes the Orbital Maneuvering Vehicle (OMV) concept and its intended role. It recaps the past activities leading up to the current concept and summarizes the present status and plans. The various types of missions and operating modes required by the OMV are described as the basis of the guidance, navigation and control (GN&C) requirements. The general GN&C problem is outlined with potential hardware solutions.

  6. Dynamic Route Guidance Using Improved Genetic Algorithms

    Directory of Open Access Journals (Sweden)

    Zhanke Yu

    2013-01-01

    Full Text Available This paper presents an improved genetic algorithm (IGA for dynamic route guidance algorithm. The proposed IGA design a vicinity crossover technique and a greedy backward mutation technique to increase the population diversity and strengthen local search ability. The steady-state reproduction is introduced to protect the optimized genetic individuals. Furthermore the junction delay is introduced to the fitness function. The simulation results show the effectiveness of the proposed algorithm.

  7. Puncture of thoracic lesions under sonographic guidance.

    OpenAIRE

    Afschrift, M; Nachtegaele, P; Voet, D; Noens, L.; Van Hove, W; Van der Straeten, M; Verdonk, G

    1982-01-01

    Thirty-six punctures of thoracic lesions have been performed with a compound B-scanner or a real-time linear-array scanner for guidance. Twenty-three fluid collections were punctured and aspiration biopsies were performed on 13 echogenic lesions. All the punctures were successful at the first attempt. No complications occurred. The results confirm the usefulness of sonography for guiding punctures of thoracic fluid effusions and solid masses. Usually a static B-scanner is sufficient, but when...

  8. Human Genetic Disorders of Axon Guidance

    OpenAIRE

    Engle, Elizabeth C

    2010-01-01

    This article reviews symptoms and signs of aberrant axon connectivity in humans, and summarizes major human genetic disorders that result, or have been proposed to result, from defective axon guidance. These include corpus callosum agenesis, L1 syndrome, Joubert syndrome and related disorders, horizontal gaze palsy with progressive scoliosis, Kallmann syndrome, albinism, congenital fibrosis of the extraocular muscles type 1, Duane retraction syndrome, and pontine tegmental cap dysplasia. Gene...

  9. International Labour Standards. A Workers' Education Manual.

    Science.gov (United States)

    International Labour Office, Geneva (Switzerland).

    Concerned with the standard-setting work of the International Labor Organization (ILO), this manual is chiefly intended to provide guidance for worker's education instructors and trade union officials. It contains nine chapters: (1) the ILO origins and history are traced and the structure is explained; (2 & 3) procedures for the origination and…

  10. Software Development Standard for Mission Critical Systems

    Science.gov (United States)

    2014-03-17

    1990, September 1990. 5 ISO/IEC 15939. International Organization for Standardization/International Electrotechnical Commission (ISO/IEC...International Electrotechnical Commission (ISO/IEC), Ergonomic requirements for office work with visual display terminals (VDTs) – Part 11, Guidance on...deliverables (such as CDRL items based on DIDs) take the form of paper documents exactly following required formats and structure. While this form

  11. Comparison of US. Military and International Electromagnetic Compatibility Guidance. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Ewing, P. D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wood, R. T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Antonescu, C. E. [Nuclear Regulatory Commission (NRC), Washington, DC (United States)

    2003-08-31

    The Oak Ridge National Laboratory (ORNL) has been engaged by the U.S. Nuclear Regulatory Commission (NRC) Office of Nuclear Regulatory Research to assist in developing the technical basis for regulatory guidance on electromagnetic interference (EMI) and radio-frequency interference (RFI) immunity and power surge withstand capability (SWC). Previous research has provided recommendations on electromagnetic compatibility (EMC) design and installation practices, endorsement of EMII/RFI immunity and SWC test criteria and test methods, and determination of ambient electromagnetic conditions at nuclear power plants. These recommendations have been incorporated into the technical basis for guidance in addressing EMI/RFI and power surges in safety-related instrumentation and control (I&C) systems in nuclear power plants. The recommendations by the ORNL staff on test criteria, test methods, and operating envelopes were significantly influenced by the military standards issued by the U.S. Department of Defense (DOD). That is the case because until recently there were no comprehensive commercial standards that covered EMI/RFI immunity. The present research involves reviewing and assessing the commercial standards issued by the International Electrotechnical Commission (IEC) and endorsed by the European Union in the last few years. This document reports the results of a study performed by the ORNL staff comparing Regulatory Guide 1.180, the U.S. military standards, and international EMC guidance.

  12. Education, consultation, guidance, students, advisor, teacher

    Directory of Open Access Journals (Sweden)

    M Seyedmajidi

    2013-09-01

    Full Text Available Introduction: Student counseling and supervision play an important role to overcome learning problems and to achieve educational goals. The present study is intended to investigate viewpoints of students regarding educational guidance and advice studying at Babol University of Medical Sciences. Methods: In this descriptive cross-sectional survey, viewpoints of 480 students were collected by a questionnaire. The validity and reliability of the questionnaire had been approved before. Data were analyzed using SPSS version 17 software. Chi- square and ANOVA tests were administered. Results: 61.2% of all participants were female and 38.8% were males with mean age of 21.3±4.0. 37.2% of these students lacked sufficient knowledge and information on how to request from their advisors for help and guidance. Half of students (50.3% reported attendance of advisors and holding routine consultation is inappropriate. Advisors made more educational files for females compare to males (P=0.001. No difference observed regarding educational disciplines of the advisors regarding students were dissatisfied with help and guidance received from paramedics and dentistry students in most fields (87.3% and 81.5% respectively. Conclusion: It seems that either student has no sufficient information about tasks of advisors and/or advisors may not do their tasks properly. It is recommended the students to be acquainted with advisors’ tasks upon their entrance into the university. Training classes for new academics would be helpful.

  13. EPA guidance on cultural competence training.

    Science.gov (United States)

    Schouler-Ocak, Meryam; Graef-Calliess, Iris T; Tarricone, Ilaria; Qureshi, Adil; Kastrup, Marianne C; Bhugra, Dinesh

    2015-03-01

    The stress of migration as well as social factors and changes related to the receiving society may lead to the manifestation of psychiatric disorders in vulnerable individuals after migration. The diversity of cultures, ethnicities, races and reasons for migration poses a challenge for those seeking to understand how illness is experienced by immigrants whose backgrounds differ significantly from their clinicians. Cultural competence represents good clinical practice and can be defined as such that a clinician regards each patient in the context of the patient's own culture as well as from the perspective of the clinician's cultural values and prejudices. The EPA Guidance on cultural competence training outlines some of the key issues related to cultural competence and how to deal with these. It points out that cultural competence represents a comprehensive response to the mental health care needs of immigrant patients and requires knowledge, skills and attitudes which can improve the effectiveness of psychiatric treatment. To reach these aims, both individual and organizational competence are needed, as well as teaching competence in terms of educational leadership. The WPA Guidance on Mental Health and Mental Health Care for Migrants and the EPA Guidance on Mental Health Care for Migrants list a series of recommendations for policy makers, service providers and clinicians; these are aimed at improving mental health care for immigrants. The authors of this paper would like to underline these recommendations and, focusing on cultural competency and training, believe that they will be of positive value. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  14. NRC ARDC Guidance Support Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Holbrook, Mark R. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-07-01

    This report provides a summary that reflects the progress and status of proposed regulatory design criteria for advanced non-light water reactor (LWR) designs in accordance with the Level 3 milestone M3AT-17IN2001013 in work package AT-17IN200101. These criteria have been designated as advanced reactor design criteria (ARDC) and they provide guidance to future applicants for addressing the general design criteria (GDC) that are currently applied specifically to LWR designs. This report provides a summary of Phase 2 activities related to the various tasks associated with ARDC development and the subsequent development of ARDC regulatory guidance for sodium fast reactor (SFR) and modular high-temperature gas-cooled reactor (HTGR) designs. Status Report Organization: Section 2 discusses the origin of the GDC and their application to LWRs. Section 3 addresses the objective of this initiative and how it benefits the advanced non-LWR reactor vendors. Section 4 discusses the scope and structure of the initiative. Section 5 provides background on the U.S. Department of Energy (DOE) ARDC team’s original development of the proposed ARDC that were submitted to the NRC for consideration. Section 6 provides a summary of recent ARDC Phase 2 activities. Appendices A through E document the DOE ARDC team’s public comments on various sections of the NRC’s draft regulatory guide DG–1330, “Guidance for Developing Principal Design Criteria for Non-Light Water Reactors.”

  15. Reliability history of the Apollo guidance computer

    Science.gov (United States)

    Hall, E. C.

    1972-01-01

    The Apollo guidance computer was designed to provide the computation necessary for guidance, navigation and control of the command module and the lunar landing module of the Apollo spacecraft. The computer was designed using the technology of the early 1960's and the production was completed by 1969. During the development, production, and operational phase of the program, the computer has accumulated a very interesting history which is valuable for evaluating the technology, production methods, system integration, and the reliability of the hardware. The operational experience in the Apollo guidance systems includes 17 computers which flew missions and another 26 flight type computers which are still in various phases of prelaunch activity including storage, system checkout, prelaunch spacecraft checkout, etc. These computers were manufactured and maintained under very strict quality control procedures with requirements for reporting and analyzing all indications of failure. Probably no other computer or electronic equipment with equivalent complexity has been as well documented and monitored. Since it has demonstrated a unique reliability history, it is important to evaluate the techniques and methods which have contributed to the high reliability of this computer.

  16. Guidance and control, 1993; Annual Rocky Mountain Guidance and Control Conference, 16th, Keystone, CO, Feb. 6-10, 1993

    Science.gov (United States)

    Culp, Robert D.; Bickley, George

    Papers from the sixteenth annual American Astronautical Society Rocky Mountain Guidance and Control Conference are presented. The topics covered include the following: advances in guidance, navigation, and control; control system videos; guidance, navigation and control embedded flight control systems; recent experiences; guidance and control storyboard displays; and applications of modern control, featuring the Hubble Space Telescope (HST) performance enhancement study. For individual titles, see A95-80390 through A95-80436.

  17. 77 FR 71019 - Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2012-04; Guidance on...

    Science.gov (United States)

    2012-11-28

    ... COMMISSION Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2012-04; Guidance on...: Nuclear Regulatory Commission. ACTION: Japan Lessons-Learned Project Directorate Interim Staff Guidance issuance. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is issuing the Final Japan...

  18. Is Career Guidance for the Individual or for the Market? Implications of EU Policy for Career Guidance

    Science.gov (United States)

    Bergmo-Prvulovic, Ingela

    2014-01-01

    This paper explores the essential understanding and underlying perspectives of career implicit in EU career guidance policy in the twenty-first century, as well as the possible implications of these for the future mission of guidance. Career theories, models and concepts that serve career guidance are shaped on the twentieth-century industrial…

  19. 78 FR 12759 - Draft Guidance for Industry on Attachment to Guidance on Antiviral Product Development-Conducting...

    Science.gov (United States)

    2013-02-25

    ... Antiviral Product Development--Conducting and Submitting Virology Studies to the Agency: Guidance for... guidance for industry entitled ``Attachment to Guidance on Antiviral Product Development--Conducting and... important for supporting clinical trials of products in development for the treatment of HCV. HCV...

  20. European Lifelong Guidance Policy Network Representatives' Conceptions of the Role of Information and Communication Technologies Related to National Guidance Policies

    Science.gov (United States)

    Kettunen, Jaana; Vuorinen, Raimo; Ruusuvirta, Outi

    2016-01-01

    This article reports findings from a phenomenographic investigation into European Lifelong Guidance Policy Network representatives' conceptions of the role of information and communication technologies (ICT) related to national lifelong guidance policies. The role of ICT in relation to national lifelong guidance policies was conceived as (1)…

  1. Is Career Guidance for the Individual or for the Market? Implications of EU Policy for Career Guidance

    Science.gov (United States)

    Bergmo-Prvulovic, Ingela

    2014-01-01

    This paper explores the essential understanding and underlying perspectives of career implicit in EU career guidance policy in the twenty-first century, as well as the possible implications of these for the future mission of guidance. Career theories, models and concepts that serve career guidance are shaped on the twentieth-century industrial…

  2. Accounting standards

    NARCIS (Netherlands)

    Stellinga, B.; Mügge, D.

    2014-01-01

    The European and global regulation of accounting standards have witnessed remarkable changes over the past twenty years. In the early 1990s, EU accounting practices were fragmented along national lines and US accounting standards were the de facto global standards. Since 2005, all EU listed companie

  3. Variable structure guidance law for attacking surface maneuver targets

    Institute of Scientific and Technical Information of China (English)

    Han Yanhua; Xu Bo

    2008-01-01

    The characteristics of surface maneuver targets are analyzed and a 3-D relative motion model for missiles and targets is established. A variable structure guidance law is designed considering the characteristics of targets. In the guidance law, the distance between missiles and targets as well as the missile-target relative velocity are all substituted by estimation values. The estimation errors, the target's velocity, and the maneuver acceleration are all treated as bounded disturbance. The guidance law proposed can be implemented conveniently in engineering with little target information. The performance of the guidance system is analyzed theoretically and the numerical simulation result shows the effectiveness of the guidance law.

  4. Contextual Cueing Improves Attentional Guidance, Even When Guidance Is Supposedly Optimal.

    Science.gov (United States)

    Harris, Anthony M; Remington, Roger W

    2017-02-23

    Visual search through previously encountered contexts typically produces reduced reaction times compared with search through novel contexts. This contextual cueing benefit is well established, but there is debate regarding its underlying mechanisms. Eye-tracking studies have consistently shown reduced number of fixations with repetition, supporting improvements in attentional guidance as the source of contextual cueing. However, contextual cueing benefits have been shown in conditions in which attentional guidance should already be optimal-namely, when attention is captured to the target location by an abrupt onset, or under pop-out conditions. These results have been used to argue for a response-related account of contextual cueing. Here, we combine eye tracking with response time to examine the mechanisms behind contextual cueing in spatially cued and pop-out conditions. Three experiments find consistent response time benefits with repetition, which appear to be driven almost entirely by a reduction in number of fixations, supporting improved attentional guidance as the mechanism behind contextual cueing. No differences were observed in the time between fixating the target and responding-our proxy for response related processes. Furthermore, the correlation between contextual cueing magnitude and the reduction in number of fixations on repeated contexts approaches 1. These results argue strongly that attentional guidance is facilitated by familiar search contexts, even when guidance is near-optimal. (PsycINFO Database Record

  5. The Competitive Influences of Perceptual Load and Working Memory Guidance on Selective Attention.

    Science.gov (United States)

    Tan, Jinfeng; Zhao, Yuanfang; Wang, Lijun; Tian, Xia; Cui, Yan; Yang, Qian; Pan, Weigang; Zhao, Xiaoyue; Chen, Antao

    2015-01-01

    The perceptual load theory in selective attention literature proposes that the interference from task-irrelevant distractor is eliminated when perceptual capacity is fully consumed by task-relevant information. However, the biased competition model suggests that the contents of working memory (WM) can guide attentional selection automatically, even when this guidance is detrimental to visual search. An intriguing but unsolved question is what will happen when selective attention is influenced by both perceptual load and WM guidance. To study this issue, behavioral performances and event-related potentials (ERPs) were recorded when participants were presented with a cue to either identify or hold in memory and had to perform a visual search task subsequently, under conditions of low or high perceptual load. Behavioural data showed that high perceptual load eliminated the attentional capture by WM. The ERP results revealed an obvious WM guidance effect in P1 component with invalid trials eliciting larger P1 than neutral trials, regardless of the level of perceptual load. The interaction between perceptual load and WM guidance was significant for the posterior N1 component. The memory guidance effect on N1 was eliminated by high perceptual load. Standardized Low Resolution Electrical Tomography Analysis (sLORETA) showed that the WM guidance effect and the perceptual load effect on attention can be localized into the occipital area and parietal lobe, respectively. Merely identifying the cue produced no effect on the P1 or N1 component. These results suggest that in selective attention, the information held in WM could capture attention at the early stage of visual processing in the occipital cortex. Interestingly, this initial capture of attention by WM could be modulated by the level of perceptual load and the parietal lobe mediates target selection at the discrimination stage.

  6. 75 FR 17143 - Draft Guidance for Industry and Food and Drug Administration Staff; Medical Devices; Neurological...

    Science.gov (United States)

    2010-04-05

    ... Staff; Medical Devices; Neurological and Physical Medicine Device Guidance Documents; Availability... physical medicine devices. FDA has developed a draft special controls guidance document for each of the 11... Guidance Document: Transcutaneous Electrical Stimulator for Aesthetic Purposes; Draft Guidance for...

  7. 78 FR 32667 - Draft Guidance for Industry on Rheumatoid Arthritis: Developing Drug Products for Treatment...

    Science.gov (United States)

    2013-05-31

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Rheumatoid Arthritis... guidance for industry entitled ``Rheumatoid Arthritis: Developing Drug Products for Treatment.'' This... products developed as drug-device combination products. This guidance revises the guidance for...

  8. Shuttle entry guidance revisited using nonlinear geometric methods

    Science.gov (United States)

    Mease, Kenneth D.; Kremer, Jean-Paul

    1994-11-01

    The entry guidance law for the space shuttle orbiter is revisited using nonlinear geometric methods. The shuttle guidance concept is to track a reference drag trajectory that has been designed to lead a specified range and velocity. It is shown that the approach taken in the original derivation of the shuttle entry guidance has much in common with the more recently developed feedback linearization method of differential geometric control. Using the feedback linearization method, however, an alternative, potentially superior, guidance law was formulated. Comparing the two guidance laws based performance domains in state space, taking into account the nonlinear dynamics, the alternative guidance law achieves the desired performance over larger domains in state space; the stability domain of the laws are similar. With larger operating domain for the shuttle or some other entry vehicle, the alternative guidance law should be considered.

  9. The mechanism and key molecules involved in pollen tube guidance.

    Science.gov (United States)

    Higashiyama, Tetsuya; Takeuchi, Hidenori

    2015-01-01

    During sexual reproduction of flowering plants, pollen tube guidance by pistil tissue is critical for the delivery of nonmotile sperm cells to female gametes. Multistep controls of pollen tube guidance can be divided into two phases: preovular guidance and ovular guidance. During preovular guidance, various female molecules, including stimulants for pollen germination and pollen tube growth, are provided to support tube growth toward the ovary, where the ovules are located. After entering the ovary, pollen tubes receive directional cues from their respective target ovules, including attractant peptides for precise, species-preferential attraction. Successful pollen tube guidance in the pistil requires not only nutritional and directional controls but also competency controls to make pollen tubes responsive to guidance cues, regulation to terminate growth once a pollen tube arrives at the target, and strategies to stop ovular attraction depending on the fertilization of female gametes.

  10. Implementing PAT with Standards

    Science.gov (United States)

    Chandramohan, Laakshmana Sabari; Doolla, Suryanarayana; Khaparde, S. A.

    2016-02-01

    Perform Achieve Trade (PAT) is a market-based incentive mechanism to promote energy efficiency. The purpose of this work is to address the challenges inherent to inconsistent representation of business processes, and interoperability issues in PAT like cap-and-trade mechanisms especially when scaled. Studies by various agencies have highlighted that as the mechanism evolves including more industrial sectors and industries in its ambit, implementation will become more challenging. This paper analyses the major needs of PAT (namely tracking, monitoring, auditing & verifying energy-saving reports, and providing technical support & guidance to stakeholders); and how the aforesaid reasons affect them. Though current technologies can handle these challenges to an extent, standardization activities for implementation have been scanty for PAT and this work attempts to evolve them. The inconsistent modification of business processes, rules, and procedures across stakeholders, and interoperability among heterogeneous systems are addressed. This paper proposes the adoption of specifically two standards into PAT, namely Business Process Model and Notation for maintaining consistency in business process modelling, and Common Information Model (IEC 61970, 61968, 62325 combined) for information exchange. Detailed architecture and organization of these adoptions are reported. The work can be used by PAT implementing agencies, stakeholders, and standardization bodies.

  11. Standard Review Plan Update and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    1992-05-01

    This implementing procedures document (IPD) was prepared for use in implementing tasks under the standard review plan update and development program (SRP-UDP). The IPD provides comprehensive guidance and detailed procedures for SRP-UDP tasks. The IPD is mandatory for contractors performing work for the SRP-UDP. It is guidance for the staff. At the completion of the SRP-UDP, the IPD will be revised (to remove the UDP aspects) and will replace NRR Office Letter No. 800 as long-term maintenance procedures.

  12. 76 FR 20853 - Approval and Promulgation of Air Quality Implementation Plans; Kentucky; Approval of Section 110...

    Science.gov (United States)

    2011-04-14

    ... is located (see e.g., Fig. 3-1of the above mentioned EPA report). The report concludes `` hese... the environmental benefit of the MACT standards, Kentucky's expectation that the implementation of the MACT standards will have an environmental benefit for ozone is reasonable. The Commenters do not...

  13. Gaps exist in the current guidance on the use of randomized controlled trial study protocols in systematic reviews.

    Science.gov (United States)

    Boden, Catherine; Bidonde, Julia; Busch, Angela

    2017-05-01

    The use of trial registry records and randomized controlled trial (RCT) study protocols can assist systematic reviewers in evaluating and, possibly, minimizing publication and selective reporting biases. This study examined current guidance on the use of registry records and RCT study protocols from key systematic review organizations, institutes, and collaborations. Handbooks, guidelines, and standard documents from key systematic review organizations and the EQUATOR network database were identified. Textual excerpts providing guidance on the use of trial registry records, RCT protocols, and ongoing/unpublished studies were extracted independently by two reviewers and coded into a systematic review framework. Eleven documents published in English between 2009 and 2016 were included. Guidance for using RCT protocols and trial registry records was provided for 7 of 16 framework categories, and guidance for using unpublished and ongoing studies was available for 8 of 16 categories. This study identified gaps and ambiguities in language in guidance on the use of RCT protocols and trial registry records. To encourage and assist reviewers to use trial registry records and RCT study protocols in systematic reviews, current guidance should be expanded and clarified. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Evolved Acceleration Guidance for Planetary Entry

    Science.gov (United States)

    Mease, K. D.; Leavitt, J. A.; Ferch, M.

    The U.S. Apollo and Shuttle programs have proven the viability and effectiveness of acceleration guidance. New capabilities have been developed to augment this basic concept. Algorithms have been designed for low lift to drag ratio vehicles and for mid to high lift to drag ratio vehicles. These algorithms have been tested for Mars landing and for earth entry of reusable launch vehicles and have performed well in both cases. Also the trajectory planner has been incorporated into a landing footprint generator that is designed for on-board use.

  15. Avoiding plagiarism: guidance for nursing students.

    Science.gov (United States)

    Price, Bob

    The pressures of study, diversity of source materials, past assumptions relating to good writing practice, ambiguous writing guidance on best practice and students' insecurity about their reasoning ability, can lead to plagiarism. With the use of source checking software, there is an increased chance that plagiarised work will be identified and investigated, and penalties given. In extreme cases, plagiarised work may be reported to the Nursing and Midwifery Council and professional as well as academic penalties may apply. This article provides information on how students can avoid plagiarism when preparing their coursework for submission.

  16. Communications standards

    CERN Document Server

    Stokes, A V

    1986-01-01

    Communications Standards deals with the standardization of computer communication networks. This book examines the types of local area networks (LANs) that have been developed and looks at some of the relevant protocols in more detail. The work of Project 802 is briefly discussed, along with a protocol which has developed from one of the LAN standards and is now a de facto standard in one particular area, namely the Manufacturing Automation Protocol (MAP). Factors that affect the usage of networks, such as network management and security, are also considered. This book is divided into three se

  17. Serving size guidance for consumers: is it effective?

    Science.gov (United States)

    Faulkner, G P; Pourshahidi, L K; Wallace, J M W; Kerr, M A; McCrorie, T A; Livingstone, M B E

    2012-11-01

    Larger portion sizes (PS) may be inciting over-eating and contributing to obesity rates. Currently, there is a paucity of data on the effectiveness of serving size (SS) guidance. The aims of the present review are to evaluate SS guidance; the understanding, usability and acceptability of such guidance, its impact on consumers and potential barriers to its uptake. A sample of worldwide SS guidance schemes (n 87) were identified using targeted and untargeted searches, overall these were found to communicate various inconsistent and often conflicting messages about PS selection. The available data suggest that consumers have difficulty in understanding terms such as 'portion size' and 'serving size', as these tend to be used interchangeably. In addition, discrepancies between recommended SS and those present on food labels add to the confusion. Consumers generally understand and visualise SS best when expressed in terms of household measures rather than actual weights. Only a limited number of studies have examined the direct impact of SS guidance on consumer behaviour with equivocal results. Although consumers recognise that guidance on selecting SS would be helpful, they are often unwilling to act on such guidance. The challenge of achieving consumer adherence to SS guidance is formidable due to several barriers including chronic exposure to larger PS, distorted consumption norms and perceptions, the habit of 'cleaning one's plate' and language barriers for ethnic minorities. In conclusion, the impact of SS guidance on consumers merits further investigation to ensure that future guidance resonates with consumers by being more understandable, usable and acceptable.

  18. National ethics guidance in Sub-Saharan Africa on the collection and use of human biological specimens: a systematic review.

    Science.gov (United States)

    Barchi, Francis; Little, Madison T

    2016-10-22

    Ethical and regulatory guidance on the collection and use of human biospecimens (HBS) for research forms an essential component of national health systems in Sub-Saharan Africa (SSA), where rapid advances in genetic- and genomic-based technologies are fueling clinical trials involving HBS and the establishment of large-scale biobanks. An extensive multi-level search for publicly available ethics regulatory guidance was conducted for each SSA country. A second review documented active trials listed in the WHO International Clinical Trials Registry Platform as of January 2015 in which HBS collection was specified in the protocol. Findings were combined to determine the extent to which countries that are study sites for HBS-related research are supported by regulatory guidance language on the collection, use, ownership and storage of biospecimens. Of the 49 SSA countries, 29 had some form of national ethics guidance, yet only 17 provided language relating to HBS-related research, with specific guidance on consent (14), ownership (6), reuse (10), storage (9), and export/import/transfer (13). Ten countries accounted for 84 % of the active clinical trials involving the collection of HBS in SSA. All except one of these countries were found to have some national guidance in the form of regulations, codes of ethics, and/or standard operating procedures; however, only seven of the ten offered any language specific to HBS. Despite the fact that the bulk of registered clinical trials in SSA involving HBS, as well as existing and proposed sites for biorepositories under the H3Africa Initiative, are currently situated in countries with the most complete ethics and regulatory guidance, variability in the regulations themselves may create challenges for planned and future pan-African collaborations and may require legislative action at the national level to revise. Countries in SSA that still lack regulatory guidance on HBS will require extensive health system strengthening in

  19. Augmented reality and cone beam CT guidance for transoral robotic surgery.

    Science.gov (United States)

    Liu, Wen P; Richmon, Jeremy D; Sorger, Jonathan M; Azizian, Mahdi; Taylor, Russell H

    2015-09-01

    In transoral robotic surgery preoperative image data do not reflect large deformations of the operative workspace from perioperative setup. To address this challenge, in this study we explore image guidance with cone beam computed tomographic angiography to guide the dissection of critical vascular landmarks and resection of base-of-tongue neoplasms with adequate margins for transoral robotic surgery. We identify critical vascular landmarks from perioperative c-arm imaging to augment the stereoscopic view of a da Vinci si robot in addition to incorporating visual feedback from relative tool positions. Experiments resecting base-of-tongue mock tumors were conducted on a series of ex vivo and in vivo animal models comparing the proposed workflow for video augmentation to standard non-augmented practice and alternative, fluoroscopy-based image guidance. Accurate identification of registered augmented critical anatomy during controlled arterial dissection and en bloc mock tumor resection was possible with the augmented reality system. The proposed image-guided robotic system also achieved improved resection ratios of mock tumor margins (1.00) when compared to control scenarios (0.0) and alternative methods of image guidance (0.58). The experimental results show the feasibility of the proposed workflow and advantages of cone beam computed tomography image guidance through video augmentation of the primary stereo endoscopy as compared to control and alternative navigation methods.

  20. Precision-guided surgical navigation system using laser guidance and 3D autostereoscopic image overlay.

    Science.gov (United States)

    Liao, Hongen; Ishihara, Hirotaka; Tran, Huy Hoang; Masamune, Ken; Sakuma, Ichiro; Dohi, Takeyoshi

    2010-01-01

    This paper describes a precision-guided surgical navigation system for minimally invasive surgery. The system combines a laser guidance technique with a three-dimensional (3D) autostereoscopic image overlay technique. Images of surgical anatomic structures superimposed onto the patient are created by employing an animated imaging method called integral videography (IV), which can display geometrically accurate 3D autostereoscopic images and reproduce motion parallax without the need for special viewing or tracking devices. To improve the placement accuracy of surgical instruments, we integrated an image overlay system with a laser guidance system for alignment of the surgical instrument and better visualization of patient's internal structure. We fabricated a laser guidance device and mounted it on an IV image overlay device. Experimental evaluations showed that the system could guide a linear surgical instrument toward a target with an average error of 2.48 mm and standard deviation of 1.76 mm. Further improvement to the design of the laser guidance device and the patient-image registration procedure of the IV image overlay will make this system practical; its use would increase surgical accuracy and reduce invasiveness.

  1. Evaluation of Hanau's formula in determination of lateral condylar guidance: A clinical research study

    Science.gov (United States)

    Bhawsar, Sanjay Vasant; Marathe, Ashlesha Subhash; Ansari, Sadekh Abdul

    2015-01-01

    Statement of Problem: The accuracy and reliability of the methods used for programming the semi-adjustable articulators determine the accuracy in occlusion. The current recommended average settings using the Hanau's formula commonly used by clinicians is questionable, and thus reassessment is needed. This study was carried out to evaluate and compare the lateral condylar guidance: (1) Using the Hanau's formula and the computerized jaw tracking device (Kinesiograph). (2) On the right and left sides using both these methods. Materials and Methods: A total of 20 completely edentulous patients (14 male and 6 females) within 40–60 years of age were selected. Jaw relation was recorded followed by face bow transfer. Extraoral Gothic arch tracing was recorded; three protrusive records were obtained and condylar guidance was calculated. Lateral condylar guidance was then calculated using Hanau's formula, followed by the computerized jaw tracking device. A comparative evaluation was done of the obtained values. The same investigator worked with each of the study participants for the purpose of standardization. Results: The lateral condylar guidance values obtained using the Hanau's formula ranged from 14 to 17° while those obtained using the computerized K7 jaw tracking device ranged from 8 to 40°. Bennett angle values, obtained using the jaw tracking device and Hanau's formula showed statistically significant differences (P 0.05). Conclusion: Based on the results, dentist and dental technicians should consider reassessing the current recommended average settings and use of the Hanau's formula for programming the semi-adjustable articulators. PMID:26929535

  2. 75 FR 51569 - National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion...

    Science.gov (United States)

    2010-08-20

    .... Specifically, the MACT floor limit is an upper prediction limit (UPL) calculated with the Student's t-test using the TINV function in Microsoft Excel. The Student's t-test has also been used in other EPA... testing, there were no problems meeting the quality assurance requirement in Method 323 for...

  3. NASA Human Integration Design Handbook (HIDH): Revitalization of Space-Related Human Factors, Environmental, and Habitability Data and Design Guidance

    Science.gov (United States)

    Stroud, Kenneth; Pickett, Lynn; Tillman, Barry

    2008-01-01

    This poster presentation reviews the Human Integration Design Handbook (HIDH). It provides guidance and data to aid vehicle / habitat designers in human-system integration It also aids requirements writers in development of human-system integration requirements from SFHSS Standards

  4. 78 FR 20116 - Draft Guidance for Industry and Food and Drug Administration Staff; Glass Syringes for Delivering...

    Science.gov (United States)

    2013-04-03

    ... Staff; Glass Syringes for Delivering Drug and Biological Products: Technical Information To Supplement... availability of draft guidance for industry and FDA staff entitled ``Glass Syringes for Delivering Drug and... glass syringes that comply with the ISO 11040-4 standard when connected to devices (``connecting...

  5. 78 FR 60292 - Draft Guidance for Industry on Abbreviated New Drug Application Submissions-Refuse-to-Receive...

    Science.gov (United States)

    2013-10-01

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Abbreviated New Drug Application Submissions--Refuse-to-Receive Standards; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of a...

  6. Smart Ultrasound Remote Guidance Experiment (SURGE)- Concept of Operations Evaluation for Using Remote Guidance Ultrasound for Planetary Space Flight

    Science.gov (United States)

    Hurst, Victor, IV; Peterson, Sean; Garcia, Kathleen; Sargsyan, Ashot; Ebert, Douglas; Ham, David; Amponsah, David; Dulchavsky, Scott

    2010-01-01

    Introduction Use of remote guidance (RG) techniques aboard the International Space Station (ISS) has enabled astronauts to collect diagnostic-level ultrasound images. Exploration class missions will require this cohort of (typically) non-formally trained sonographers to operate with greater autonomy given the longer communication delays (2 seconds for ISS vs. >6 seconds for missions beyond the Moon) and communication blackouts. To determine the feasibility and training requirements for autonomous ultrasound image collection by non-expert ultrasound operators, ultrasound images were collected from a similar cohort using three different image collection protocols: RG only, RG with a computer-based learning tool (LT), and autonomous image collection with LT. The groups were assessed for both image quality and time to collect the images. Methods Subjects were randomized into three groups: RG only, RG with LT, and autonomous with LT. Each subject received 10 minutes of standardized training before the experiment. The subjects were tasked with making the following ultrasound assessments: 1) bone fracture and 2) focused assessment with sonography in trauma (FAST) to assess a patient s abdomen. Human factors-related questionnaire data were collected immediately after the assessments. Results The autonomous group did not out-perform the two groups that received RG. The mean time for the autonomous group to collect images was less than the RG groups, however the mean image quality for the autonomous group was less compared to both RG groups. Discussion Remote guidance continues to produce higher quality ultrasound images than autonomous ultrasound operation. This is likely due to near-instant feedback on image quality from the remote guider. Expansion in communication time delays, however, diminishes the capability to provide this feedback, thus requiring more autonomous ultrasound operation. The LT has the potential to be an excellent training and coaching component for

  7. Investigation of the Guidance Law for an Image Homing Guidance System

    Institute of Scientific and Technical Information of China (English)

    SHANGGUAN Yin-li

    2005-01-01

    This paper aims at a type of image homing guided missile. The guided trajectory characteristics and the initial condition of the homing guidance are analyzed by calculating the miss distance of the image guided missile. Several modified proportional navigation laws which are easy for engineering implementation are introduced.

  8. Optimal guidance of extended trajectory shaping

    Institute of Scientific and Technical Information of China (English)

    Wang Hui; Lin Defu; Cheng Zhenxuan; Wang Jiang

    2014-01-01

    To control missile’s miss distance as well as terminal impact angle, by involving the time-to-go-nth power in the cost function, an extended optimal guidance law against a constant maneu-vering target or a stationary target is proposed using the linear quadratic optimal control theory. An extended trajectory shaping guidance (ETSG) law is then proposed under the assumption that the missile-target relative velocity is constant and the line of sight angle is small. For a lag-free ETSG system, closed-form solutions for the missile’s acceleration command are derived by the method of Schwartz inequality and linear simulations are performed to verify the closed-form results. Normalized adjoint systems for miss distance and terminal impact angle error are presented independently for stationary targets and constant maneuvering targets, respectively. Detailed discussions about the terminal misses and impact angle errors induced by terminal impact angle constraint, initial heading error, seeker zero position errors and target maneuvering, are performed.

  9. Research on artistic gymnastics training guidance model

    Science.gov (United States)

    Luo, Lin; Sun, Xianzhong

    2017-04-01

    Rhythmic gymnastics training guidance model, taking into consideration the features of artistic gymnastics training, is put forward to help gymnasts identify their deficiencies and unskilled technical movements and improve their training effects. The model is built on the foundation of both physical quality indicator model and artistic gymnastics training indicator model. Physical quality indicator model composed of bodily factor, flexibility-strength factor and speed-dexterity factor delivers an objective evaluation with reference to basic sport testing data. Training indicator model, based on physical fitness indicator, helps analyze the technical movements, through which the impact from each bodily factor on technical movements is revealed. AG training guidance model, in further combination with actual training data and in comparison with the data shown in the training indicator model, helps identify the problems in trainings, and thus improve the training effect. These three models when in combined use and in comparison with historical model data can check and verify the improvement in training effect over a certain period of time.

  10. Mental health promotion: guidance and strategies.

    Science.gov (United States)

    Kalra, G; Christodoulou, G; Jenkins, R; Tsipas, V; Christodoulou, N; Lecic-Tosevski, D; Mezzich, J; Bhugra, D

    2012-02-01

    Public mental health incorporates a number of strategies from mental well-being promotion to primary prevention and other forms of prevention. There is considerable evidence in the literature to suggest that early interventions and public education can work well for reducing psychiatric morbidity and resulting burden of disease. Educational strategies need to focus on individual, societal and environmental aspects. Targeted interventions at individuals will also need to focus on the whole population. A nested approach with the individual at the heart of it surrounded by family surrounded by society at large is the most suitable way to approach this. This Guidance should be read along with the European Psychiatric Association (EPA) Guidance on Prevention. Those at risk of developing psychiatric disorders also require adequate interventions as well as those who may have already developed illness. However, on the model of triage, mental health and well-being promotion need to be prioritized to ensure that, with the limited resources available, these activities do not get forgotten. One possibility is to have separate programmes for addressing concerns of a particular population group, another that is relevant for the broader general population. Mental health promotion as a concept is important and this will allow prevention of some psychiatric disorders and, by improving coping strategies, is likely to reduce the burden and stress induced by mental illness. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  11. Achieving Standardization

    DEFF Research Database (Denmark)

    Henningsson, Stefan

    2014-01-01

    competitive, national customs and regional economic organizations are seeking to establish a standardized solution for digital reporting of customs data. However, standardization has proven hard to achieve in the socio-technical e-Customs solution. In this chapter, the authors identify and describe what has...

  12. Achieving Standardization

    DEFF Research Database (Denmark)

    Henningsson, Stefan

    2016-01-01

    competitive, national customs and regional economic organizations are seeking to establish a standardized solution for digital reporting of customs data. However, standardization has proven hard to achieve in the socio-technical e-Customs solution. In this chapter, the authors identify and describe what has...

  13. Computer-based written emotional disclosure: the effects of advance or real-time guidance and moderation by Big 5 personality traits.

    Science.gov (United States)

    Beyer, Jonathan A; Lumley, Mark A; Latsch, Deborah V; Oberleitner, Lindsay M S; Carty, Jennifer N; Radcliffe, Alison M

    2014-01-01

    Standard written emotional disclosure (WED) about stress, which is private and unguided, yields small health benefits. The effect of providing individualized guidance to writers may enhance WED, but has not been tested. This trial of computer-based WED compared two novel therapist-guided forms of WED - advance guidance (before sessions) and real-time guidance (during sessions, through instant messaging) - to both standard WED and control writing; it also tested Big 5 personality traits as moderators of guided WED. Young adult participants (n = 163) with unresolved stressful experiences were randomized to conditions, had three, 30-min computer-based writing sessions, and were reassessed six weeks later. Contrary to hypotheses, real-time guidance WED had poorer outcomes than the other conditions on several measures, and advance guidance WED also showed some poorer outcomes. Moderator analyses revealed that participants with low baseline agreeableness, low extraversion, or high conscientiousness had relatively poor responses to guidance. We conclude that providing guidance for WED, especially in real-time, may interfere with emotional processing of unresolved stress, particularly for people whose personalities have poor fit with this interactive form of WED.

  14. Movement Strategy Discovery during Training via Haptic Guidance.

    Science.gov (United States)

    Gibo, Tricia L; Abbink, David A

    2016-01-01

    Haptic guidance has previously been investigated to facilitate motor skill training, whereupon a robotic device assists a trainee in executing the desired movement. However, many studies have reported a null or even detrimental effect of haptic guidance on training compared to unassisted practice. While prior studies have focused on using haptic guidance to refine a movement strategy, our study explores its effect on the discovery of a new strategy. Subjects learned to manipulate a virtual under-actuated system via a haptic device either with or without haptic guidance (and without haptic feedback of system dynamics). The guidance enabled subjects to experience a range of successful movements, rather than strictly enforcing one trajectory. Subjects who trained with guidance adopted a strategy that involved faster reaches, required greater control of the system's degrees of freedom, and increased the potential for faster task completion. However, overall improvement of task performance was limited with the new strategy.

  15. Guidance and dispersion studies of National Launch System ascent trajectories

    Science.gov (United States)

    Hanson, John M.; Shrader, M. W.; Chang, Hopen; Freeman, Scott E.

    1992-01-01

    The National Launch System (NLS) is a joint concept, between DoD and NASA, for building a family of new launch vehicles. Two of the many choices to be made are the trajectory shaping methods and the onboard guidance scheme. This paper presents results from some ongoing studies to address these issues. First, potential gains from new guidance concepts are listed. Next the paper gives a list of possible discriminators between different guidance schemes, lists a number of potential guidance schemes, and explains two in some detail. A reference scheme is tested to determine its performance versus the discriminators. Finally, results from some special studies using the reference guidance scheme are given, including the effects of closed-loop guidance initiation time, time of enforcement of sideslip, vehicle roll for engine out, time and location of an engine out, use of load relief control, and use of day of launch wind biasing.

  16. Trajectory reshaping based guidance with impact time and angle constraints

    Directory of Open Access Journals (Sweden)

    Zhao Yao

    2016-08-01

    Full Text Available This study presents a novel impact time and angle constrained guidance law for homing missiles. The guidance law is first developed with the prior-assumption of a stationary target, which is followed by the practical extension to a maneuvering target scenario. To derive the closed-form guidance law, the trajectory reshaping technique is utilized and it results in defining a specific polynomial function with two unknown coefficients. These coefficients are determined to satisfy the impact time and angle constraints as well as the zero miss distance. Furthermore, the proposed guidance law has three additional guidance gains as design parameters which make it possible to adjust the guided trajectory according to the operational conditions and missile’s capability. Numerical simulations are presented to validate the effectiveness of the proposed guidance law.

  17. Human factors engineering in oil and gas--a review of industry guidance.

    Science.gov (United States)

    Robb, Martin; Miller, Gerald

    2012-01-01

    Oil and gas exploration and production activities are carried out in hazardous environments in many parts of the world. Recent events in the Gulf of Mexico highlight those risks and underline the importance of considering human factors during facility design. Ergonomic factors such as machinery design, facility and accommodation layout and the organization of work activities have been systematically considered over the past twenty years on a limited number of offshore facility design projects to a) minimize the occupational risks to personnel, b) support operations and maintenance tasks and c) improve personnel wellbeing. During this period, several regulators and industry bodies such as the American Bureau of Shipping (ABS), the American Society of Testing and Materials (ASTM), the UK's Health and Safety Executive (HSE), Oil and Gas Producers (OGP), and Norway's Petroleum Safety Authority (PSA) have developed specific HFE design standards and guidance documents for the application of Human Factors Engineering (HFE) to the design and operation of Oil and Gas projects. However, despite the existence of these guidance and recommended design practise documents, and documented proof of their value in enhancing crew safety and efficiency, HFE is still not well understood across the industry and application across projects is inconsistent. This paper summarizes the key Oil and Gas industry bodies' HFE guidance documents, identifies recurring themes and current trends in the use of these standards, provides examples of where and how these HFE standards have been used on past major offshore facility design projects, and suggests criteria for selecting the appropriate HFE strategy and tasks for future major oil and gas projects. It also provides a short history of the application of HFE to the offshore industry, beginning with the use of ASTM F 1166 to a major operator's Deepwater Gulf of Mexico facility in 1990 and the application of HFE to diverse world regions. This

  18. United States Federal Guidance on Witness Protection in Human Trafficking

    Science.gov (United States)

    2015-06-12

    UNITED STATES FEDERAL GUIDANCE ON WITNESS PROTECTION IN HUMAN TRAFFICKING A thesis presented to the Faculty of the U.S. Army...JUN 2015 4. TITLE AND SUBTITLE United States Federal Guidance on Witness Protection in Human Trafficking 5a. CONTRACT NUMBER 5b. GRANT NUMBER...United States needs overarching federal guidance on witness protection for human trafficking victims/witnesses in order to enhance their safety and

  19. 77 FR 62434 - Policy Letters on the International Convention on Standards of Training, Certification and...

    Science.gov (United States)

    2012-10-15

    ... Standards of Training, Certification and Watchkeeping for Seafarers, 1978, as amended (STCW). These letters provide guidance on: The hours of rest requirements of the 2010 amendments to the STCW Convention and Code... guidance to affected parties until regulations implementing amendments to the STCW are promulgated....

  20. Integrating mechanisms of visual guidance in naturalistic language production.

    Science.gov (United States)

    Coco, Moreno I; Keller, Frank

    2015-05-01

    Situated language production requires the integration of visual attention and linguistic processing. Previous work has not conclusively disentangled the role of perceptual scene information and structural sentence information in guiding visual attention. In this paper, we present an eye-tracking study that demonstrates that three types of guidance, perceptual, conceptual, and structural, interact to control visual attention. In a cued language production experiment, we manipulate perceptual (scene clutter) and conceptual guidance (cue animacy) and measure structural guidance (syntactic complexity of the utterance). Analysis of the time course of language production, before and during speech, reveals that all three forms of guidance affect the complexity of visual responses, quantified in terms of the entropy of attentional landscapes and the turbulence of scan patterns, especially during speech. We find that perceptual and conceptual guidance mediate the distribution of attention in the scene, whereas structural guidance closely relates to scan pattern complexity. Furthermore, the eye-voice span of the cued object and its perceptual competitor are similar; its latency mediated by both perceptual and structural guidance. These results rule out a strict interpretation of structural guidance as the single dominant form of visual guidance in situated language production. Rather, the phase of the task and the associated demands of cross-modal cognitive processing determine the mechanisms that guide attention.

  1. Axon guidance and neuronal migration research in China

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Proper migration of neuronal somas and axonal growth cones to designated locations in the developing brain is essential for the assembly of functional neuronal circuits.Rapid progress in research of axon guidance and neuronal migration has been made in the last twenty years.Chinese researchers began their exploration in this field ten years ago and have made significant contributions in clarifying the signal transduction of axon guidance and neuronal migration.Several unique experimental approaches,including the migration assay of single isolated neurons in response to locally delivered guidance cues,have been developed by Chinese neuroscientists to investigate the molecular machinery underlying these guidance events.

  2. The temporal dynamics of visual working memory guidance of selective attention

    Directory of Open Access Journals (Sweden)

    Jinfeng eTan

    2014-09-01

    Full Text Available The biased competition model proposes that there is top-down directing of attention to a stimulus matching the contents of working memory (WM, even when the maintenance of a WM representation is detrimental to target relevant performance. Despite many studies elucidating that spatial WM guidance can be present early in the visual processing system, whether visual WM guidance also influences perceptual selection remains poorly understood. Here, we investigated the electrophysiological correlates of early guidance of attention by WM in humans. Participants were required to perform a visual search task while concurrently maintaining object representations in their visual working memory. Behavioral results showed that response times (RTs were longer when the distractor in the visual search task was held in WM. The earliest WM guidance effect was observed in the P1 component (90-130 ms, with match trials eliciting larger P1 amplitude than mismatch trials. A similar result was also found in the N1 component (160-200 ms. These P1 and N1 effects could not be attributed to bottom-up perceptual priming from the presentation of a memory cue, because there was no significant difference in early ERP component when the cue was merely perceptually identified but not actively held in working memory. Standardized Low Resolution Electrical Tomography Analysis (sLORETA showed that the early WM guidance occurred in the occipital lobe and the N1-related activation occurred in the parietal gyrus. Time-frequency data suggested that alpha-band event-related spectral perturbation (ERSP magnitudes increased under the match condition compared with the mismatch condition. In conclusion, the present study suggests that the reappearance of a stimulus held in WM enhanced activity in the occipital area. Subsequently, this initial capture of attention by WM could be inhibited by competing visual inputs through attention re-orientation, reflecting by the alpha-band rhythm.

  3. (Terminology standardization)

    Energy Technology Data Exchange (ETDEWEB)

    Strehlow, R.A.

    1990-10-19

    Terminological requirements in information management was but one of the principal themes of the 2nd Congress on Terminology and Knowledge Engineering. The traveler represented the American Society for Testing and Materials' Committee on Terminology, of which he is the Chair. The traveler's invited workshop emphasized terminology standardization requirements in databases of material properties as well as practical terminology standardizing methods. The congress included six workshops in addition to approximately 82 lectures and papers from terminologists, artificial intelligence practitioners, and subject specialists from 18 countries. There were approximately 292 registrants from 33 countries who participated in the congress. The congress topics were broad. Examples were the increasing use of International Standards Organization (ISO) Standards in legislated systems such as the USSR Automated Data Bank of Standardized Terminology, the enhanced Physics Training Program based on terminology standardization in Physics in the Chinese province of Inner Mongolia, and the technical concept dictionary being developed at the Japan Electronic Dictionary Research Institute, which is considered to be the key to advanced artificial intelligence applications. The more usual roles of terminology work in the areas of machine translation. indexing protocols, knowledge theory, and data transfer in several subject specialties were also addressed, along with numerous special language terminology areas.

  4. EMP Attachment 3 DOE-SC PNNL Site Dose Assessment Guidance

    Energy Technology Data Exchange (ETDEWEB)

    Snyder, Sandra F.

    2011-12-21

    This Dose Assessment Guidance (DAG) describes methods to use to determine the Maximally-Exposed Individual (MEI) location and to estimate dose impact to that individual under the U.S. Department of Energy Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Site Environmental Monitoring Plan (EMP). This guidance applies to public dose from radioactive material releases to the air from PNNL Site operations. This document is an attachment to the Pacific Northwest National Laboratory (PNNL) Environmental Monitoring Plan (EMP) and describes dose assessment guidance for radiological air emissions. The impact of radiological air emissions from the U.S. Department of Energy Office of Science (DOE-SC) PNNL Site is indicated by dose estimates to a maximally exposed member of the public, referred to as the maximally exposed individual (MEI). Reporting requirements associated with dose to members of the public from radiological air emissions are in 40 CFR Part 61.94, WAC 246-247-080, and DOE Order 458.1. The DOE Order and state standards for dose from radioactive air emissions are consistent with U.S. Environmental Protection Agency (EPA) dose standards in 40 CFR 61.92 (i.e., 10 mrem/yr to a MEI). Despite the fact that the current Contract Requirements Document (CRD) for the DOE-SC PNNL Site operations does not include the requirement to meet DOE CRD 458.1, paragraph 2.b, public dose limits, the DOE dose limits would be met when EPA limits are met.

  5. Optical technologies for intraoperative neurosurgical guidance.

    Science.gov (United States)

    Valdés, Pablo A; Roberts, David W; Lu, Fa-Ke; Golby, Alexandra

    2016-03-01

    Biomedical optics is a broadly interdisciplinary field at the interface of optical engineering, biophysics, computer science, medicine, biology, and chemistry, helping us understand light-tissue interactions to create applications with diagnostic and therapeutic value in medicine. Implementation of biomedical optics tools and principles has had a notable scientific and clinical resurgence in recent years in the neurosurgical community. This is in great part due to work in fluorescence-guided surgery of brain tumors leading to reports of significant improvement in maximizing the rates of gross-total resection. Multiple additional optical technologies have been implemented clinically, including diffuse reflectance spectroscopy and imaging, optical coherence tomography, Raman spectroscopy and imaging, and advanced quantitative methods, including quantitative fluorescence and lifetime imaging. Here we present a clinically relevant and technologically informed overview and discussion of some of the major clinical implementations of optical technologies as intraoperative guidance tools in neurosurgery.

  6. Technical guidance for siting criteria development

    Energy Technology Data Exchange (ETDEWEB)

    Aldrich, D.C.; Sprung, J.L.; Alpert, D.J.; Diegert, K.; Ostmeyer, R.M.; Ritchie, L.T.; Strip, D.R.; Johnson, J.D.; Hansen, K.; Robinson, J.

    1982-12-01

    Technical guidance to support the formulation and comparison of possible siting criteria for nuclear power plants has been developed in four areas: (1) consequences of hypothetical severe nuclear-power-plant accidents, (2) characteristics of population distributions about current reactor sites, (3) site availability within the continental United States, and (4) socioeconomic impacts of reactor siting. The impact on consequences of source-term magnitude, meteorology, population distribution, and emergency response have been analyzed. Population distributions about current sites were analyzed to identify statistical characteristics, time trends, and regional differences. A site-availability data bank was constructed for the continential United States. The data bank contains information about population densities, seismicity, topography, water availability, and land-use restrictions. Finally, the socioeconomic impacts of rural-industrialization projects, energy boomtowns, and nuclear power plants were examined to determine their nature, magnitude, and dependence on site demography and remoteness.

  7. Improvements in inservice testing regulatory guidance

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, P.L.

    1996-12-01

    Over the last few years, the NRC has issued guidance to licensees toward improving the quality of requests for relief or alternatives to the code requirements and bring some measure of consistency to the implementation of the code requirements. Based on the majority of the recent submittals, the overall quality has improved. If all of the steps in the internal process for responding to the requests are timely, the review of an updated program can be completed in six to nine months. When a single or only a few requests are submitted, the staff is generally able to complete an evaluation in less than three months. When schedules are related to outages or exigent circumstances, the NRC responds accordingly. The improvements in schedules can be attributed to publication of staff guideline documents, licensees` efforts in preparing more complete descriptions and justification and an increase in the number of NRC technical staff reviewers assigned to IST.

  8. D & D screening risk evaluation guidance

    Energy Technology Data Exchange (ETDEWEB)

    Robers, S.K.; Golden, K.M.; Wollert, D.A.

    1995-09-01

    The Screening Risk Evaluation (SRE) guidance document is a set of guidelines provided for the uniform implementation of SREs performed on decontamination and decommissioning (D&D) facilities. Although this method has been developed for D&D facilities, it can be used for transition (EM-60) facilities as well. The SRE guidance produces screening risk scores reflecting levels of risk through the use of risk ranking indices. Five types of possible risk are calculated from the SRE: current releases, worker exposures, future releases, physical hazards, and criticality. The Current Release Index (CRI) calculates the current risk to human health and the environment, exterior to the building, from ongoing or probable releases within a one-year time period. The Worker Exposure Index (WEI) calculates the current risk to workers, occupants and visitors inside contaminated D&D facilities due to contaminant exposure. The Future Release Index (FRI) calculates the hypothetical risk of future releases of contaminants, after one year, to human health and the environment. The Physical Hazards Index (PHI) calculates the risks to human health due to factors other than that of contaminants. Criticality is approached as a modifying factor to the entire SRE, due to the fact that criticality issues are strictly regulated under DOE. Screening risk results will be tabulated in matrix form, and Total Risk will be calculated (weighted equation) to produce a score on which to base early action recommendations. Other recommendations from the screening risk scores will be made based either on individual index scores or from reweighted Total Risk calculations. All recommendations based on the SRE will be made based on a combination of screening risk scores, decision drivers, and other considerations, as determined on a project-by-project basis.

  9. Dopaminergic axon guidance: which makes what?

    Directory of Open Access Journals (Sweden)

    Laetitia ePrestoz

    2012-07-01

    Full Text Available Mesotelencephalic pathways in the adult central nervous system have been studied in great detail because of their implication in major physiological functions as well as in psychiatric, neurological and neurodegenerative diseases. However, the ontogeny of these pathways and the molecular mechanisms that guide dopaminergic axons during embryogenesis have been only recently studied. This line of research is of crucial interest for the repair of lesioned circuits in adulthood following neurodegenerative diseases or common traumatic injuries. For instance, in the adult, the anatomic and functional repair of the nigrostriatal pathway following dopaminergic embryonic neuron transplantation suggests that specific guidance cues exist which govern embryonic fibers outgrowth, and suggests that axons from transplanted embryonic cells are able to respond to theses cues, which then guide them to their final targets. In this review, we first synthesize the work that has been performed in the last few years on developing mesotelencephalic pathways, and summarize the current knowledge on the identity of cellular and molecular signals thought to be involved in establishing mesotelencephalic dopaminergic neuronal connectivity during embryogenesis in the central nervous system of rodents. Then, we review the modulation of expression of these molecular signals in the lesioned adult brain and discuss their potential role in remodeling the mesotelencephalic dopaminergic circuitry, with a particular focus on Parkinson’s disease. Identifying guidance molecules involved in the connection of grafted cells may be useful for cellular therapy in Parkinsonian patients, as these molecules may help direct axons from grafted cells along the long distance they have to travel from the substantia nigra to the striatum.

  10. Statistical guidance on seasonal forecast of Korean dust days over South Korea in the springtime

    Science.gov (United States)

    Sohn, Keon Tae

    2013-09-01

    This study aimed to develop the seasonal forecast models of Korean dust days over South Korea in the springtime. Forecast mode was a ternary forecast (below normal, normal, above normal) which was classified based on the mean and the standard deviation of Korean dust days for a period of 30 years (1981-2010). In this study, we used three kinds of monthly data: the Korean dust days observed in South Korea, the National Center for Environmental Prediction in National Center for Atmospheric Research (NCEP/NCAR) reanalysis data for meteorological factors over source regions of Asian dust, and the large-scale climate indices offered from the Climate Diagnostic Center and Climate Prediction Center in NOAA. Forecast guidance consisted of two components; ordinal logistic regression model to generate trinomial distributions, and conversion algorithm to generate ternary forecast by two thresholds. Forecast guidance was proposed for each month separately and its predictability was evaluated based on skill scores.

  11. Preparing raw clinical data for publication: guidance for journal editors, authors, and peer reviewers.

    Science.gov (United States)

    Hrynaszkiewicz, Iain; Norton, Melissa L; Vickers, Andrew J; Altman, Douglas G

    2010-01-29

    In recognition of the benefits of transparent reporting, many peer-reviewed journals require that their authors be prepared to share their raw, unprocessed data with other scientists and/or state the availability of raw data in published articles. But little information on how data should be prepared for publication - or sharing - has emerged. In clinical research patient privacy and consent for use of personal health information are key considerations, but agreed-upon definitions of what constitutes anonymised patient information do not appear to have been established. We aim to address this issue by providing practical guidance for those involved in the publication process, by proposing a minimum standard for de-identifying datasets for the purposes of publication in a peer-reviewed biomedical journal, or sharing with other researchers. Basic advice on file preparation is provided along with procedural guidance on prospective and retrospective publication of raw data, with an emphasis on randomised controlled trials.

  12. Cone-beam CT-guidance in Interventional Radiology

    NARCIS (Netherlands)

    Braak, S.J.

    2012-01-01

    OBJECTIVE. CBCT-guidance (CBCT-guidance) is a new stereotactic technique for needle interventions, combining 3D soft-tissue cone-beam CT, needle planningsoftware, and real-time fluoroscopy. Our objective was to evaluate the use, feasibility and outcome of this technique. To determine the effectiv

  13. Some Practical Remedies for Providing Vocational Guidance for Everyone.

    Science.gov (United States)

    Holland, John L.

    After describing some current problems in vocational guidance and summarizing relevant knowledge and theory in the field, this paper presents some practical plans, materials, and ideas for providing more useful vocational assistance to people of all ages. The paper reviews such prominent vocational guidance approaches as vocational information and…

  14. A Theory-Ridden, Computerless, Impersonal Vocational Guidance System.

    Science.gov (United States)

    Holland, John L.

    Beginning with a brief summary of the need for practical vocational guidance systems, the author explains his Self Directed Search for Educational and Vocational Planning (SDS), which was developed to provide a cheap, practical, vocational guidance system having a high degree of scientific validty and client effectiveness. The SDS is a…

  15. An Introductory Guide to the Community College Guidance Profile (CCGP).

    Science.gov (United States)

    Holland, John L.

    The Community College Guidance Profile (CCGP) was developed to accelerate and simplify the assessment process in vocational and educational guidance. The CCGP includes six main sections which are concerned with: (1) educational and vocational aspirations, (2) self estimates of abilities and personal traits, (3) vocational interests, (4) activities…

  16. 78 FR 49782 - Interim Staff Guidance on Changes During Construction

    Science.gov (United States)

    2013-08-15

    ... COMMISSION Interim Staff Guidance on Changes During Construction AGENCY: Nuclear Regulatory Commission. ACTION: Draft interim staff guidance; request for comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is issuing this notice for use of, and to solicit public comment on the draft Interim...

  17. Environmental Guidance Program Reference Book: American Indian Religious Freedom Act

    Energy Technology Data Exchange (ETDEWEB)

    1987-11-01

    This Reference Book contains a copy of the American Indian Religious Freedom Act and guidance for DOE compliance with the statute. The document is provided to DOE and contractor staff for informational purposes only and should not be interpreted as legal guidance. Updates that include important new requirements will be provided periodically.

  18. Meta-Narrative on Guidance and Counselling in Schools

    Science.gov (United States)

    Thamarasseri, Ismail

    2014-01-01

    The purposes of guidance and counselling provide emphasis and strength to the educational program. The major goals of counselling are to promote personal growth and to prepare students to become motivated workers and responsible citizens. The chief aim of an educational guidance is to develop the ability of co-ordinating with the school…

  19. Rethinking Careers Education and Guidance: Theory, Policy and Practice.

    Science.gov (United States)

    Watts, A. G.; Law, Bill; Killeen, John; Kidd, Jennifer M.; Hawthorn, Ruth

    This book contains 21 papers on the theory, context, provision, practice, and development of career counseling and guidance in Great Britain. The following papers are included: "Preface" (Tony Watts et al.); "The Social Context of Guidance" (John Killeen); "Career Theory" (John Killeen); "A Career-Learning…

  20. Finding the Optimal Guidance for Enhancing Anchored Instruction

    Science.gov (United States)

    Zydney, Janet Mannheimer; Bathke, Arne; Hasselbring, Ted S.

    2014-01-01

    This study investigated the effect of different methods of guidance with anchored instruction on students' mathematical problem-solving performance. The purpose of this research was to iteratively design a learning environment to find the optimal level of guidance. Two iterations of the software were compared. The first iteration used explicit…

  1. Interdisciplinarity in Vocational Guidance: An Action Theory Perspective

    Science.gov (United States)

    Valach, Ladislav; Young, Richard A.

    2009-01-01

    In addressing the issue of interdisciplinary research in vocational guidance, twelve propositions important for understanding the vocational guidance process as joint, goal-directed action are presented. They address the encounter between client and counsellor leading to relational ethics, the relevance of everyday action theory and methods for…

  2. Critical Perspectives on Adolescent Vocational Guidance in Chile

    Science.gov (United States)

    McWhirter, Ellen Hawley; McWhirter, Benedict T.

    2012-01-01

    In this article, the lens of critical psychology is applied to adolescent career development and vocational guidance in Chile. The authors describe and critique the status of adolescent vocational guidance in Chile, the reproduction of extant social inequities in Chilean education, and offer recommendations for enhancing vocational guidance…

  3. Guidance on the environmental risk assessment of plant pests

    DEFF Research Database (Denmark)

    Baker, R.; Candresse, T.; Dormannsne Simon, E.

    2011-01-01

    the environmental risks of plant pests that have previously been used in pest risk assessment. The limitations identified by the review led the Panel to define the new methodology for environmental risk assessment which is described in this guidance document. The guidance is primarily addressed to the EFSA PLH...

  4. 75 FR 70009 - Development of Health Risk Assessment Guidance

    Science.gov (United States)

    2010-11-16

    ... HUMAN SERVICES Centers for Disease Control and Prevention Development of Health Risk Assessment Guidance... guidance concerning Health Risk Assessment (HRAs). Section 4103 of the Affordable Care Act (ACA) (Pub. L. 111-148) requires that a health risk assessment be included in the annual wellness visit benefit...

  5. Critical Perspectives on Adolescent Vocational Guidance in Chile

    Science.gov (United States)

    McWhirter, Ellen Hawley; McWhirter, Benedict T.

    2012-01-01

    In this article, the lens of critical psychology is applied to adolescent career development and vocational guidance in Chile. The authors describe and critique the status of adolescent vocational guidance in Chile, the reproduction of extant social inequities in Chilean education, and offer recommendations for enhancing vocational guidance…

  6. Guidance of Nonlinear Nonminimum-Phase Dynamic Systems

    Science.gov (United States)

    Devasia, Santosh

    1997-01-01

    The first two years research work has advanced the inversion-based guidance theory for: (1) systems with non-hyperbolic internal dynamics; (2) systems with parameter jumps; (3) systems where a redesign of the output trajectory is desired; and (4) the generation of recovery guidance maneuvers.

  7. Exemplary Career Guidance Programs 1995: Secondary and Postsecondary.

    Science.gov (United States)

    Cunanan, Esmeralda S.; Maddy-Bernstein, Carolyn

    This document presents nine exemplary career guidance and counseling programs identified by the National Center for Research in Vocational Education's Office of Student Services. Chapter 1 presents a synthesis of the nationally recognized career guidance programs successful in assisting students in their career development. It provides a…

  8. Operator radiation exposure in cone-beam computed tomography guidance

    NARCIS (Netherlands)

    Braak, S.J.; Strijen Van, M. J L; Meijer, E.; Heesewijk Van, J. P M; Mali, W. P T M

    2016-01-01

    Objectives: Quantitative analysis of operator dose in cone-beam computed tomography guidance (CBCT-guidance) and the effect of protective shielding. Methods: Using a Rando phantom, a model was set-up to measure radiation dose for the operator hand, thyroid and gonad region. The effect of sterile rad

  9. Career Guidance and Social Exclusion: A Cautionary Tale.

    Science.gov (United States)

    Watts, A. G.

    2001-01-01

    Examines the relationship of career guidance to public-policy interventions designed to address social exclusion. Analyzes the nature and origin of the concept of social exclusion and reviews the roles of career guidance in response to it, particularly in relation to young people who have dropped out of formal education or are at high risk of…

  10. Counseling, Guidance, and the Morality of Help-Giving

    Science.gov (United States)

    Patton, Michael J.

    1971-01-01

    A review of: (1) The Counseling Center in Higher Education, Phillip J. Gallagher and George D. Demos, (2) The Guidance Process, Herman J. Peters, (3) Counseling and Guidance in the Twentieth Century: Reflections and Reformulations, William H. Van Hoose and John J. Pietrofesa, and (4) Value Orientations in Counseling and Psychotherapy: The Meanings…

  11. Making Connections: Guidance and Career Education in the Middle Years.

    Science.gov (United States)

    Levi, Marion; Ziegler, Suzanne

    This report is an examination of recommended and actual school-based guidance policies, programs, and practices for young adolescents. The information is drawn from Canadian and international publications, and from a survey of guidance and career education programs for grades 7-8 in Ontario boards of education and schools, called The 1990 Ontario…

  12. Thinking Differently about Guidance: Power, Children's Autonomy and Democratic Environments

    Science.gov (United States)

    Millei, Zsuzsa

    2012-01-01

    This article critiques guidance approaches to discipline, that are employed in early childhood environments with an aim to create democratic environments for children, and as part of "good" practices. Advocates of guidance claim that this is a more humane or democratic approach to discipline that empowers children, and therefore, power in the…

  13. 76 FR 81513 - Guidance for Industry: Prevention of Salmonella

    Science.gov (United States)

    2011-12-28

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry: Prevention of Salmonella Enteritidis... availability of a guidance for industry entitled ``Prevention of Salmonella Enteritidis in Shell Eggs During... with certain provisions contained in FDA's final rule ``Prevention of Salmonella Enteritidis in...

  14. Educating Career Guidance Practitioners in the Twenty-First Century

    Science.gov (United States)

    Gough, John

    2017-01-01

    Rapidly changing policy contexts in England have dramatically affected the provision of career guidance, and the training and development of its practitioners. This paper takes an autoethnographic and self-reflexive approach to exploring the experience of a Senior Lecturer in Career Guidance who manages a centre that offers the Qualification in…

  15. Quality assurance and evidence in career guidance in Europe

    DEFF Research Database (Denmark)

    Plant, Peter

    2011-01-01

    Quality assurance and evidence in career guidance in Europe is based on a particular, positivtic model. Other approaches are largely neglected.......Quality assurance and evidence in career guidance in Europe is based on a particular, positivtic model. Other approaches are largely neglected....

  16. Career Guidance and Social Inclusion: A Challenge for Europe

    Science.gov (United States)

    Sultana, Ronald G.

    2010-01-01

    This paper discusses the way career guidance is conceived across Europe as a policy instrument that can facilitate social inclusion. It locates current articulations of career guidance within the broader social-market aspirations of the European Union, providing an account of several reviews and analyses of the field that have been carried out at…

  17. National All-Age Career Guidance Services: Evidence and Issues

    Science.gov (United States)

    Watts, A. G.

    2010-01-01

    The three major national all-age career guidance services--in New Zealand, Scotland and Wales--have been reviewed using an adaptation of the methodology adopted in the OECD Career Guidance Policy Review. The main features of the three services are summarised, and some key differences and distinctive strengths are outlined. The alternative approach…

  18. The Well-Being Outcomes of Career Guidance

    Science.gov (United States)

    Robertson, Peter J.

    2013-01-01

    The potential for career guidance to impact on well-being has received insufficient attention in the UK. There are both conceptual and empirical reasons to expect that the impacts may be positive, but a lack of evidence directly testing this proposition. Career guidance has commonalities with therapeutic counselling suggesting analogous effects,…

  19. 32 CFR 147.6 - Guidance D-Sexual behavior.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Guidance D-Sexual behavior. 147.6 Section 147.6... Guidance D—Sexual behavior. (a) The concern. Sexual behavior is a security concern if it involves a..., exploitation, or duress, or reflects lack of judgment or discretion. 1 Sexual orientation or preference may not...

  20. Key performance indicators for the assessment of pediatric pharmacotherapeutic guidance.

    Science.gov (United States)

    Barrett, Jeffrey S; Patel, Dimple; Jayaraman, Bhuvana; Narayan, Mahesh; Zuppa, Athena

    2008-07-01

    Given the paucity of actual guidance provided for managing pediatric drug therapy, prescribing caregivers must be able to draw on the limited published information in pediatrics and/or guidance provided in adults with some account for expected pediatric response. Guidance for managing drug therapy in children is clearly desirable. Our objectives were to construct key performance indicators (KPIs) for pediatric pharmacotherapy guidance to identify drugs where pharmacotherapy guidance would be most beneficial. A pilot survey to assess variation in caregiver appreciation for pediatric dosing guidance has also been constructed to provide a complementary subjective assessment. Three KPI categories, drug utilization (based on hospital admission and billing data collected from 2001 through 2006), medical need, and guidance outcome value along with a KPI composite score have been proposed. Low scores are favored with respect to prioritization for pharmacotherapy guidance. The pilot survey consisted of 15 questions to assess 1) physician knowledge regarding dosing guidance, 2) attitudes toward dose modification and patient individualization, 3) the accessibility, ease of use and appropriateness of existing data stores, and 4) frequency of dosing modification, consultation of dosing compendiums and estimate of success rate in dosing guidance. Pilot results suggest that dosing guidance is generally viewed as important and that the existing resources are insufficient to guide recommendations for all drugs. While the majority of respondents check more than one resource less than 25% of the time, at least 25% of the respondents check more than one resource 25-50% of the time. The majority viewed the relevance of dosing guidance very important to the management of drug therapy. The questionnaire is being extended to the primary care centers, the Kids First Network and specialty care centers. Results will guide the development of decision support systems (DSS) that provide patient

  1. Frequency standards

    CERN Document Server

    Riehle, Fritz

    2006-01-01

    Of all measurement units, frequency is the one that may be determined with the highest degree of accuracy. It equally allows precise measurements of other physical and technical quantities, whenever they can be measured in terms of frequency.This volume covers the central methods and techniques relevant for frequency standards developed in physics, electronics, quantum electronics, and statistics. After a review of the basic principles, the book looks at the realisation of commonly used components. It then continues with the description and characterisation of important frequency standards

  2. Extended High-Gain Observer for Mars Entry Guidance

    Directory of Open Access Journals (Sweden)

    Pingyuan Cui

    2013-02-01

    Full Text Available To deliver a Mars entry vehicle to the prescribed parachute deployment point, active entry guidance is essential. This paper addresses the problem of Mars atmospheric entry guidance through drag tracking method with extended high gain observer. First, an extended high gain observer combined with feedback linearization is applied in drag tracking for Mars entry longitudinal guidance.  The observer estimates the drag and drag rate for drag tracking, estimates the perturbation due to model uncertainty and disturbance, and compensate for the perturbation by canceling its estimate. Then, bank reversal is adopted in the lateral plane to reduce the cross-range error. Finally, Mars entry simulation is performed to assess the performance of the adaptive guidance law. The results demonstrate that the proposed guidance law exhibits good performance.

  3. European Universities' Guidance on Research Integrity and Misconduct.

    Science.gov (United States)

    Aubert Bonn, Noémie; Godecharle, Simon; Dierickx, Kris

    2017-02-01

    Research integrity is imperative to good science. Nonetheless, many countries and institutions develop their own integrity guidance, thereby risking incompatibilities with guidance of collaborating institutions. We retrieved guidance for academic integrity and misconduct of 18 universities from 10 European countries and investigated accessibility, general content, principles endorsed, and definitions of misconduct. Accessibility and content differ substantially between institutions. There are general trends of common principles of integrity and definitions of misconduct, yet differences remain. Parallel with previous research, we distinguish different approaches in integrity guidance; one emphasizes broad values of integrity, and the other details negative behaviors of misconduct. We propose that a balance between both approaches is necessary to preserve trust, meaning, and realism of guidance on research integrity.

  4. Guidance Receptors in the Nervous and Cardiovascular Systems.

    Science.gov (United States)

    Rubina, K A; Tkachuk, V A

    2015-10-01

    Blood vessels and nervous fibers grow in parallel, for they express similar receptors for chemokine substances. Recently, much attention is being given to studying guidance receptors and their ligands besides the growth factors, cytokines, and chemokines necessary to form structures in the nervous and vascular systems. Such guidance molecules determine trajectory for growing axons and vessels. Guidance molecules include Ephrins and their receptors, Neuropilins and Plexins as receptors for Semaphorins, Robos as receptors for Slit-proteins, and UNC5B receptors binding Netrins. Apart from these receptors and their ligands, urokinase and its receptor (uPAR) and T-cadherin are also classified as guidance molecules. The urokinase system mediates local proteolysis at the leading edge of cells, thereby providing directed migration. T-cadherin is a repellent molecule that regulates the direction of growing axons and blood vessels. Guidance receptors also play an important role in the diseases of the nervous and cardiovascular systems.

  5. A Three-Dimensional Cooperative Guidance Law of Multimissile System

    Directory of Open Access Journals (Sweden)

    Xing Wei

    2015-01-01

    Full Text Available In order to conduct saturation attacks on a static target, the cooperative guidance problem of multimissile system is researched. A three-dimensional guidance model is built using vector calculation and the classic proportional navigation guidance (PNG law is extended to three dimensions. Based on this guidance law, a distributed cooperative guidance strategy is proposed and a consensus protocol is designed to coordinate the time-to-go commands of all missiles. Then an expert system, which contains two extreme learning machines (ELM, is developed to regulate the local proportional coefficient of each missile according to the command. All missiles can arrive at the target simultaneously under the assumption that the multimissile network is connected. A simulation scenario is given to demonstrate the validity of the proposed method.

  6. A guide to CERCLA site assessment. Environmental Guidance

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-01

    This Pocket Guide is a condensed version of information provided in three EPA documents: Guidance for Performing Preliminary Assessments Under CERCLA, Guidance for Performing Site Inspections Under CERCLA, and Hazard Ranking System Guidance Manual. Additionally the guide provides a DOE perspective on site assessment issues and information on the Federal Agency Hazardous Waste Compliance Docket as well as data sources for DOE site assessments. The guide is intended to present this information in a simple, portable, and direct manner that will allow the user to effectively focus on those aspects of the site assessment process of interest. The guide is not intended as a substitute for the three EPA guidance documents mentioned previously. DOE investigators should be thoroughly familiar with the EPA guidance before conducting site assessments. Use this pocketguide as an overview of procedures and requirements and as a field guide.

  7. Axon growth and guidance: receptor regulation and signal transduction.

    Science.gov (United States)

    O'Donnell, Michael; Chance, Rebecca K; Bashaw, Greg J

    2009-01-01

    The development of precise connectivity patterns during the establishment of the nervous system depends on the regulated action of diverse, conserved families of guidance cues and their neuronal receptors. Determining how these signaling pathways function to regulate axon growth and guidance is fundamentally important to understanding wiring specificity in the nervous system and will undoubtedly shed light on many neural developmental disorders. Considerable progress has been made in defining the mechanisms that regulate the correct spatial and temporal distribution of guidance receptors and how these receptors in turn signal to the growth cone cytoskeleton to control steering decisions. This review focuses on recent advances in our understanding of the mechanisms mediating growth cone guidance with a particular emphasis on the control of guidance receptor regulation and signaling.

  8. A review of solutions for diagnostic accuracy studies with an imperfect or missing reference standard

    NARCIS (Netherlands)

    J.B. Reitsma; A.W.S. Rutjes; K.S. Khan; A. Coomarasamy; P.M. Bossuyt

    2009-01-01

    Objective: In diagnostic accuracy studies, the reference standard may be imperfect or not available in all patients. We systematically reviewed the proposed solutions for these situations and generated methodological guidance. Study Design and Setting: Review of methodological articles. Results: We

  9. An Investigation of the Guidance Counselling Needs of Adults with Dyslexia in the Adult Educational Guidance Initiative (AEGI)

    Science.gov (United States)

    Elftorp, Petra; Hearne, Lucy

    2014-01-01

    The experiences of adult learners with dyslexia is an under-researched area in Ireland at present. This article will discuss the findings from phase one of a mixed methods research study, which is investigating the guidance counselling needs of clients with dyslexia within the Adult Education Guidance Initiative (AEGI). The research is underpinned…

  10. 78 FR 12761 - Guidance for Industry: Guidance on the Labeling of Certain Uses of Lecithin Derived From Soy...

    Science.gov (United States)

    2013-02-25

    ... Labeling of Certain Uses of Lecithin Derived From Soy Under Section 403(w) of the Federal Food, Drug, and... ``Guidance for Industry: Guidance on the Labeling of Certain Uses of Lecithin Derived From Soy Under Section... certain uses of lecithin derived from soy under the Federal Food, Drug, and Cosmetic Act (the FD&C Act...

  11. 76 FR 48870 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

    Science.gov (United States)

    2011-08-09

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance Document: Herpes Simplex Virus Types 1 and 2 Serological Assays; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and...

  12. 75 FR 69089 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

    Science.gov (United States)

    2010-11-10

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance Document: Tissue Adhesive With Adjunct Wound Closure Device Intended for the Topical Approximation of Skin; Availability AGENCY: Food and Drug Administration, HHS....

  13. 76 FR 22906 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

    Science.gov (United States)

    2011-04-25

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance Document: Topical Oxygen Chamber for Extremities; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA)...

  14. 76 FR 6622 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

    Science.gov (United States)

    2011-02-07

    ... (special controls) under section 513(f)(2) of the Federal Food, Drug, and Cosmetic Act (the FD&C Act) (21 U... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance Document: Contact Cooling System for Aesthetic Use;...

  15. 76 FR 43332 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

    Science.gov (United States)

    2011-07-20

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance Document: Focused Ultrasound Stimulator System for Aesthetic Use; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and...

  16. 75 FR 70271 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

    Science.gov (United States)

    2010-11-17

    ... wound therapy into class II (special controls) under section 513(f)(2) of the Federal Food, Drug, and... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance Document: Non-Powered Suction Apparatus Device Intended for...

  17. 76 FR 29251 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls; Guidance...

    Science.gov (United States)

    2011-05-20

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls; Guidance Document: Topical Oxygen Chamber for Extremities; Availability; Correction AGENCY: Food and Drug Administration, HHS. ACTION: Notice; correction. SUMMARY: The Food and...

  18. 76 FR 20992 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

    Science.gov (United States)

    2011-04-14

    ... into class II (special controls) under section 513(f)(2) of the Federal Food, Drug, and Cosmetic Act... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance Document: Low Level Laser System for Aesthetic Use;...

  19. 75 FR 68364 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

    Science.gov (United States)

    2010-11-05

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance Document: Full-Field Digital Mammography System; Availability AGENCY: Food and Drug Administration, HHS. ] ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA)...

  20. 76 FR 16425 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

    Science.gov (United States)

    2011-03-23

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance Document: Ovarian Adnexal Mass Assessment Score Test System; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and...

  1. Standard Review Plan Maintenance Program implementing procedures document

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    The implementing Procedures Document (IPD) was developed by the Inspection Program Projects Branch, Office of Nuclear Reactor Regulation, with assistance from Pacific Northwest National Laboratory, for the Standard Review Plan Maintenance Program (SRP-MP). The SRP-MP was established to maintain the Standard Review Plan (SRP) on an on-going basis. The IPD provides guidance, including an overall approach and procedures, for SRP-MP tasks. The objective of the IPD is to ensure that modifications to SRP need to reflect current NRC requirements and guidance are identified and that a consistent methodology is used to develop and revise SRP sections.

  2. 75 FR 76011 - Annual Guidance Agenda

    Science.gov (United States)

    2010-12-07

    ... Design for Early Phase Studies of Cellular and Gene Therapies. CATEGORY--OTHER Office of Communication...: CMC Information Standards Recognition Residual Drug in Transdermal Drug Delivery Systems Category... Computer- Assisted Detection Devices Applied to Radiology Images and Radiology Device Data...

  3. Review of the IEEE Standard for Computerized Operating Procedure Systems

    Energy Technology Data Exchange (ETDEWEB)

    O' Hara, J.; Higgins, J.

    2010-02-26

    Increasingly nuclear power plant procedures, such as emergency operating procedures, are being presented in computer form with functionality to support operator use and management of the procedures. The U.S. Nuclear Regulatory Commission (NRC) currently has guidance for the review of computer-based procedures (CBPs); however, there remain CBP functions and human performance issues for which up-to-date guidance is lacking. The Institute of Electrical and Electronics Engineers (IEEE) has initiated a standard development effort to address the human factors engineering (HFE) aspects of CBP systems. When completed, it may provide guidance to supplement the NRC staff's review criteria. The purpose of our study was to evaluate the suitability of the IEEE Standard for use in the NRC's HFE safety reviews of CBP systems and to ensure that the guidance meets the NRC's standard for scientific and engineering rigor used in its own guidance development efforts. We established the following criteria with which to evaluate the Standard: (1) it should meet an existing need of NRC reviewers, (2) it should be based in sound HFE principles, (3) it should be thoroughly peer-reviewed, and (4) it should address CBP-related human performance issues identified in the literature. This report describes the methodology we used to evaluate each criterion. Our evaluation concluded that the Standard generally does meet these criteria, however several areas were identified for which additional clarifications are needed. Thus consideration of the Standard's use by the NRC is supported. The standard evaluation methodology developed in this study can be generally applied to the review of other HFE standards being considered for possible use or endorsement by the NRC.

  4. Space Telescope Fine Guidance Sensor Bearing Anomaly

    Science.gov (United States)

    Loewenthal, S.; Esper, J.; Pan, J.; Decker, J.

    1996-01-01

    Early in 1993, a servo motor within one of three Fine Guidance Sensors (FGS) aboard the Hubble Space Telescope (HST) reached stall torque levels on several occasions. Little time was left to plan replacement during the first servicing mission, scheduled at the end of '93. Accelerated bearing life tests confirmed that a small angle rocking motion, known as Coarse Track (CT), accelerated bearing degradation. Saturation torque levels were reached after approximately 20 million test cycles, similar to the flight bearings. Reduction in CT operation, implemented in flight software, extended FGS life well beyond the first servicing mission. However in recent years, bearing torques have resumed upward trends and together with a second, recent bearing torque anomaly has necessitated a scheduled FGS replacement during the upcoming second servicing mission in '97. The results from two series of life tests to quantify FGS bearing remaining life, discussion of bearing on-orbit performance, and future plans to service the FGS servos are presented in this paper.

  5. Integrating scientific guidance into marine spatial planning.

    Science.gov (United States)

    Rassweiler, Andrew; Costello, Christopher; Hilborn, Ray; Siegel, David A

    2014-04-22

    Marine spatial planning (MSP), whereby areas of the ocean are zoned for different uses, has great potential to reduce or eliminate conflicts between competing management goals, but only if strategically applied. The recent literature overwhelmingly agrees that including stakeholders in these planning processes is critical to success; but, given the countless alternative ways even simple spatial regulations can be configured, how likely is it that a stakeholder-driven process will generate plans that deliver on the promise of MSP? Here, we use a spatially explicit, dynamic bioeconomic model to show that stakeholder-generated plans are doomed to fail in the absence of strong scientific guidance. While strategically placed spatial regulations can improve outcomes remarkably, the vast majority of possible plans fail to achieve this potential. Surprisingly, existing scientific rules of thumb do little to improve outcomes. Here, we develop an alternative approach in which models are used to identify efficient plans, which are then modified by stakeholders. Even if stakeholders alter these initial proposals considerably, results hugely outperform plans guided by scientific rules of thumb. Our results underscore the importance of spatially explicit dynamic models for the management of marine resources and illustrate how such models can be harmoniously integrated into a stakeholder-driven MSP process.

  6. Guidance manual for conducting technology demonstration activities

    Energy Technology Data Exchange (ETDEWEB)

    Jolley, Robert L.; Morris, Michael I.; Singh, Suman P.N.

    1991-12-01

    This demonstration guidance manual has been prepared to assist Martin Marietta Energy Systems, Inc. (Energy Systems), staff in conducting demonstrations. It is prepared in checklist style to facilitate its use and assumes that Energy Systems personnel have project management responsibility. In addition to a detailed step-by-step listing of procedural considerations, a general checklist, logic flow diagram, and several examples of necessary plans are included to assist the user in developing an understanding of the many complex activities required to manage technology demonstrations. Demonstrations are pilot-scale applications of often innovative technologies to determine the commercial viability of the technologies to perform their designed function. Demonstrations are generally conducted on well-defined problems for which existing technologies or processes are less than satisfactory in terms of effectiveness, cost, and/or regulatory compliance. Critically important issues in demonstration management include, but are not limited to, such factors as communications with line and matrix management and with the US Department of Energy (DOE) and Energy Systems staff responsible for management oversight, budgetary and schedule requirements, regulatory compliance, and safety.

  7. Control method for video guidance sensor system

    Science.gov (United States)

    Howard, Richard T. (Inventor); Book, Michael L. (Inventor); Bryan, Thomas C. (Inventor)

    2005-01-01

    A method is provided for controlling operations in a video guidance sensor system wherein images of laser output signals transmitted by the system and returned from a target are captured and processed by the system to produce data used in tracking of the target. Six modes of operation are provided as follows: (i) a reset mode; (ii) a diagnostic mode; (iii) a standby mode; (iv) an acquisition mode; (v) a tracking mode; and (vi) a spot mode wherein captured images of returned laser signals are processed to produce data for all spots found in the image. The method provides for automatic transition to the standby mode from the reset mode after integrity checks are performed and from the diagnostic mode to the reset mode after diagnostic operations are carried out. Further, acceptance of reset and diagnostic commands is permitted only when the system is in the standby mode. The method also provides for automatic transition from the acquisition mode to the tracking mode when an acceptable target is found.

  8. Minisatellite Attitude Guidance Using Reaction Wheels

    Directory of Open Access Journals (Sweden)

    Ion STROE

    2015-06-01

    Full Text Available In a previous paper [2], the active torques needed for the minisatellite attitude guidance from one fixed attitude posture to another fixed attitude posture were determined using an inverse dynamics method. But when considering reaction/momentum wheels, instead of this active torques computation, the purpose is to compute the angular velocities of the three reaction wheels which ensure the minisatellite to rotate from the initial to the final attitude. This paper presents this computation of reaction wheels angular velocities using a similar inverse dynamics method based on inverting Euler’s equations of motion for a rigid body with one fixed point, written in the framework of the x-y-z sequence of rotations parameterization. For the particular case A=B not equal C of an axisymmetric minisatellite, the two computations are compared: the active torques computation versus the computation of reaction wheels angular velocities ̇x , ̇y and ̇z. An interesting observation comes out from this numerical study: if the three reaction wheels are identical (with Iw the moment of inertia of one reaction wheel with respect to its central axis, then the evolutions in time of the products between Iw and the derivatives of the reaction wheels angular velocities, i.e. ̇ , ̇ and ̇ remain the same and do not depend on the moment of inertia Iw.

  9. Guidance and control for unmanned ground vehicles

    Science.gov (United States)

    Bateman, Peter J.

    1994-06-01

    Techniques for the guidance, control, and navigation of unmanned ground vehicles are described in terms of the communication bandwidth requirements for driving and control of a vehicle remote from the human operator. Modes of operation are conveniently classified as conventional teleoperation, supervisory control, and fully autonomous control. The fundamental problem of maintaining a robust non-line-of-sight communications link between the human controller and the remote vehicle is discussed, as this provides the impetus for greater autonomy in the control system and the greatest scope for innovation. While supervisory control still requires the man to be providing the primary navigational intelligence, fully autonomous operation requires that mission navigation is provided solely by on-board machine intelligence. Methods directed at achieving this performance are described using various active and passive sensing of the terrain for route navigation and obstacle detection. Emphasis is given to TV imagery and signal processing techniques for image understanding. Reference is made to the limitations of current microprocessor technology and suitable computer architectures. Some of the more recent control techniques involve the use of neural networks, fuzzy logic, and data fusion and these are discussed in the context of road following and cross country navigation. Examples of autonomous vehicle testbeds operated at various laboratories around the world are given.

  10. Evaluation of native hyaline cartilage and repair tissue after two cartilage repair surgery techniques with 23Na MR imaging at 7 T: initial experience.

    Science.gov (United States)

    Zbýň, S; Stelzeneder, D; Welsch, G H; Negrin, L L; Juras, V; Mayerhoefer, M E; Szomolanyi, P; Bogner, W; Domayer, S E; Weber, M; Trattnig, S

    2012-08-01

    To compare the sodium normalized mean signal intensity (NMSI) values between patients after bone marrow stimulation (BMS) and matrix-associated autologous chondrocyte transplantation (MACT) cartilage repair procedures. Nine BMS and nine MACT patients were included. Each BMS patient was matched with one MACT patient according to age [BMS 36.7 ± 10.7 (mean ± standard deviation) years; MACT 36.9 ± 10.0 years], postoperative interval (BMS 33.5 ± 25.3 months; MACT 33.2 ± 25.7 months), and defect location. All magnetic resonance imaging (MRI) measurements were performed on a 7 T system. Proton images served for morphological evaluation of repair tissue using the magnetic resonance observation of cartilage repair tissue (MOCART) scoring system. Sodium NMSI values in the repair area and morphologically normal cartilage were calculated. Clinical outcome was assessed right after MRI. Analysis of covariance, t-tests, and Pearson correlation coefficients were evaluated. Sodium NMSI was significantly lower in BMS (P = 0.004) and MACT (P = 0.006) repair tissue, compared to reference cartilage. Sodium NMSI was not different between the reference cartilage in MACT and BMS patients (P = 0.664), however it was significantly higher in MACT than in BMS repair tissue (P = 0.028). Better clinical outcome was observed in BMS than in MACT patients. There was no difference between MOCART scores for MACT and BMS patients (P = 0.915). We did not observe any significant correlation between MOCART score and sodium repair tissue NMSI (r = -0.001; P = 0.996). Our results suggest higher glycosaminoglycan (GAG) content, and therefore, repair tissue of better quality in MACT than in BMS patients. Sodium imaging might be beneficial in non-invasive evaluation of cartilage repair surgery efficacy. Copyright © 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  11. International Conference on Harmonisation; guidance on E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs; availability. Notice.

    Science.gov (United States)

    2005-10-20

    The Food and Drug Administration (FDA) is announcing the availability of a guidance entitled "E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs." The guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The guidance provides recommendations to sponsors concerning clinical studies to assess the potential of a new drug to cause cardiac arrhythmias, focusing on the assessment of changes in the QT/QTc interval on the electrocardiogram as a predictor of risk. The guidance is intended to encourage the assessment of drug effects on the QT/QTc interval as a standard part of drug development and to encourage the early discussion of this assessment with FDA.

  12. A Further Look at X-33 Entry Guidance and Beyond

    Science.gov (United States)

    Lu, Ping

    1999-01-01

    An entry guidance design developed at Iowa State University (ISU) for the X-33 advanced technology demonstrator is outlined and compared with the X-33 entry guidance algorithms developed at NASA Marshall. Both designs are based on the Space Shuttle entry guidance concept, but significant improvements have been made to enhance the performance and reduce the complexity. The ISU design was incorporated into MAVERIC, a high fidelity vehicle simulation software for the X-33, and evaluated in Monte Carlo simulations against random dispersions in propulsion system, wind and atmospheric properties, aerodynamic coefficients, interaction between propulsion and aerodynamics, and navigation data. The simulations clearly demonstrated the capability and precision of the ISU entry guidance design in successfully guiding the X-33 in some rather difficult flight scenarios. As the entry guidance development for the X-33 is completing, this report also offers some review of the strength and limitations of the current Shuttle-based entry guidance framework, and finally some potential candidates for next generation of more capable and cost-effective entry guidance designs are discussed.

  13. Three-dimensional robust diving guidance for hypersonic vehicle

    Science.gov (United States)

    Zhu, Jianwen; Liu, Luhua; Tang, Guojian; Bao, Weimin

    2016-01-01

    A novel three-dimensional robust guidance law based on H∞ filter and H∞ control is proposed to meet the constraints of the impact accuracy and the flight direction under process disturbances for the dive phase of hypersonic vehicle. Complete three-dimensional coupling relative motion equations are established and decoupled into linear ones by feedback linearization to simplify the design process of the further guidance law. Based on the linearized equations, H∞ filter is introduced to eliminate the measurement noises of line-of-sight angles and estimate the angular rates. Furthermore, H∞ robust control is well employed to design guidance law, and the filtered information is used to generate guidance commands to meet the guidance goal accurately and robustly. The simulation results of CAV-H indicate that the proposed three-dimensional equations can describe the coupling character more clearly than the traditional decoupling guidance, and the proposed guidance strategy can guide the vehicle to satisfy different multiple constraints with high accuracy and robustness.

  14. Image guidance in endoscopic sinus surgery and skull base surgery

    Institute of Scientific and Technical Information of China (English)

    Mitchell R.Gore; Brent A.Senior

    2012-01-01

    Objective The objective of this study was to review the current clinical applications and impact of intraoperative imaging on endoscopic sinonasal and skull base procedures in adult and pediatric patients.Methods The PubMed database was searched for articles related to the use of image guidance in otolaryngology using the search terms "image guidance otolaryngology".This was supplemented by the authors′ experience utilizing image guidance in nearly 3000 endoscopic sinus and skull base procedures.Results The literature demonstrates that intraoperative image guidance has utility in primary and revision endoscopic sinus surgery,as well as endoscopic surgery of the skull base.Image guidance also has applications in pediatric endoscopic surgery,such as pediatric sinus surgery and repair of choanal atresia.Conclusions Intraoperative image guidance,when combined with a thorough knowledge of paranasal sinus and skull base anatomy and technical proficiency,can provide improved safety when performing otolaryngologic procedures from endoscopic sinus surgery to endoscopic skull base surgery.While not a substitute for knowledge of anatomy,the increased availability and usability of image guidance systems make them a useful tool in the armamentarium of the otolaryngologist/head and neck surgeon and neurosurgeon.

  15. 76 FR 72952 - Guidance for Industry on Nonclinical Evaluation of Late Radiation Toxicity of Therapeutic...

    Science.gov (United States)

    2011-11-28

    ... a guidance for industry entitled ``Nonclinical Evaluation of Late Radiation Toxicity of Therapeutic... guidance represents the Agency's current thinking on nonclinical evaluation of late radiation toxicity of... HUMAN SERVICES Food and Drug Administration Guidance for Industry on Nonclinical Evaluation of...

  16. 78 FR 33848 - Draft Guidance for Industry on Human Immunodeficiency Virus-1 Infection: Developing...

    Science.gov (United States)

    2013-06-05

    ... No. FDA-2013-D-0589] Draft Guidance for Industry on Human Immunodeficiency Virus-1 Infection... guidance for industry entitled ``Human Immunodeficiency Virus-1 Infection: Developing Antiretroviral Drugs... guidance for industry entitled ``Human Immunodeficiency Virus-1 Infection: Developing Antiretroviral...

  17. 76 FR 9583 - Draft Guidance for Industry on Clinical Pharmacogenomics: Premarketing Evaluation in Early Phase...

    Science.gov (United States)

    2011-02-18

    ... guidance for industry entitled ``Clinical Pharmacogenomics: Premarketing Evaluation in Early Phase Clinical Studies.'' The draft guidance is intended to assist the pharmaceutical industry and other investigators... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Clinical...

  18. 77 FR 62247 - Dynamic Positioning Operations Guidance for Vessels Other Than Mobile Offshore Drilling Units...

    Science.gov (United States)

    2012-10-12

    ...] Dynamic Positioning Operations Guidance for Vessels Other Than Mobile Offshore Drilling Units Operating on... voluntary guidance titled ``Mobile Offshore Drilling Unit Dynamic Positioning Guidance''. The notice recommended owners and operators of Mobile Offshore Drilling Units (MODUs) follow Marine Technology...

  19. 77 FR 61417 - Guidance for Industry on Acute Bacterial Sinusitis: Developing Drugs for Treatment; Availability

    Science.gov (United States)

    2012-10-09

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry on Acute Bacterial Sinusitis... entitled ``Acute Bacterial Sinusitis: Developing Drugs for Treatment.'' This guidance addresses FDA's... an indication for the treatment of acute bacterial sinusitis (ABS). This guidance finalizes the...

  20. 78 FR 31943 - Draft Guidance for Industry on Contract Manufacturing Arrangements for Drugs: Quality Agreements...

    Science.gov (United States)

    2013-05-28

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Contract Manufacturing... guidance for industry entitled ``Contract Manufacturing Arrangements for Drugs: Quality Agreements.'' This... draft guidance for industry entitled ``Contract Manufacturing Arrangements for Drugs: Quality...

  1. 75 FR 63189 - Draft Guidance for Industry on Investigational New Drug Applications-Determining Whether Human...

    Science.gov (United States)

    2010-10-14

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Investigational New Drug... Drug Administration (FDA) is announcing the availability of a draft guidance for industry entitled... draft guidance for industry entitled ``Investigational New Drug Applications (INDs)--Determining...

  2. 77 FR 20025 - Draft Guidance for Industry on Compliance Policy for Reporting Drug Sample Distribution...

    Science.gov (United States)

    2012-04-03

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Compliance Policy for... guidance for industry entitled ``Compliance Policy on Reporting Drug Sample Distribution Information Under... availability of a draft guidance for industry entitled ``Compliance Policy on Reporting Drug...

  3. 78 FR 57395 - Guidance for Industry on Electronic Source Data in Clinical Investigations; Availability

    Science.gov (United States)

    2013-09-18

    ... ``Electronic Source Data in Clinical Investigations.'' This document provides guidance to sponsors, contract... retention of electronic source data in FDA-regulated clinical investigations. This guidance promotes... a guidance for industry entitled ``Electronic Source Data in Clinical Investigations.''...

  4. 77 FR 58399 - Draft Guidance for Industry on Bioequivalence Recommendations for Pentosan Polysulfate Sodium...

    Science.gov (United States)

    2012-09-20

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Bioequivalence... guidance for industry entitled ``Bioequivalence Recommendations for Pentosan Polysulfate Sodium.'' The recommendations provide specific guidance on the design of bioequivalence (BE) studies to support abbreviated...

  5. Resection of deep-seated gliomas using neuroimaging for stereotactic placement of guidance catheters

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, Kengo; Higashi, Hisato; Tomita, Susumu; Furuta, Tomohisa; Ohmoto, Takashi [Okayama Univ. (Japan). School of Medicine

    1995-03-01

    A simple computed tomography- (CT) or magnetic resonance (MR) imaging-guided stereotactic method for guided microsurgical resection of either deep-seated gliomas or tumors adjacent to an eloquent area is described. The technique employs the Brown-Roberts-Wells stereotactic system and twist drills, 2.7 mm in diameter, for the stereotactic placement of 2.4 mm diameter scaled guidance catheters through the calvaria. In a patient with a deep-seated small glioma, less than 2 cm diameter, one catheter was implanted into the center of the enhanced mass through the cerebral cortex. In the other 14 patients, three to six catheters were used which made the tumor border clearer. After implantation of the guidance catheters, the stereotactic frame was removed and a standard open craniotomy performed. Target localization is not affected by brain movement, which is inevitable during open surgery. The tumor involved the frontal lobe in eight patients, the parietal lobe in two, and the thalamus in five. In all cases the lesion was quickly localized and radical removal was acheived. Neurological complications occurred in only one patient who suffered transient hemiparesis after the resection of a lesion in the pyramidal tract. The results demonstrate that microsurgery combined with CT- or MR imaging-guided stereotactic placement of guidance catheters is a new option for surgery of deep-seated gliomas or tumors adjacent to an eloquent area. (author).

  6. Feasibility of real-time magnetic resonance imaging for catheter guidance in electrophysiology studies.

    Science.gov (United States)

    Nazarian, Saman; Kolandaivelu, Aravindan; Zviman, Menekhem M; Meininger, Glenn R; Kato, Ritsushi; Susil, Robert C; Roguin, Ariel; Dickfeld, Timm L; Ashikaga, Hiroshi; Calkins, Hugh; Berger, Ronald D; Bluemke, David A; Lardo, Albert C; Halperin, Henry R

    2008-07-15

    Compared with fluoroscopy, the current imaging standard of care for guidance of electrophysiology procedures, magnetic resonance imaging (MRI) provides improved soft-tissue resolution and eliminates radiation exposure. However, because of inherent magnetic forces and electromagnetic interference, the MRI environment poses challenges for electrophysiology procedures. In this study, we sought to test the feasibility of performing electrophysiology studies with real-time MRI guidance. An MRI-compatible electrophysiology system was developed. Catheters were targeted to the right atrium, His bundle, and right ventricle of 10 mongrel dogs (23 to 32 kg) via a 1.5-T MRI system using rapidly acquired fast gradient-echo images (approximately 5 frames per second). Catheters were successfully positioned at the right atrial, His bundle, and right ventricular target sites of all animals. Comprehensive electrophysiology studies with recording of intracardiac electrograms and atrial and ventricular pacing were performed. Postprocedural pathological evaluation revealed no evidence of thermal injury to the myocardium. After proof of safety in animal studies, limited real-time MRI-guided catheter mapping studies were performed in 2 patients. Adequate target catheter localization was confirmed via recording of intracardiac electrograms in both patients. To the best of our knowledge, this is the first study to report the feasibility of real-time MRI-guided electrophysiology procedures. This technique may eliminate patient and staff radiation exposure and improve real-time soft tissue resolution for procedural guidance.

  7. Anthropometry of Iranian Guidance School Students with Different Ethnicities: A Comparative Study

    Directory of Open Access Journals (Sweden)

    Amir Houshang Mehrparvar

    2015-01-01

    Full Text Available Objective. We measured some anthropometric dimensions of Iranian guidance school students selected from different ethnicities. Background. Anthropometric dimensions are used for design of equipment, furniture, and clothing. Furniture with inappropriate design not fulfilling the users’ anthropometric dimensions may have a negative effect on health. Method. A total of 7400 Iranian guidance school students aged 12–14 years entered the study and their static anthropometric dimensions were measured. Descriptive statistics such as mean, standard deviation, and key percentiles were calculated. All dimensions were compared among different ethnicities and different genders. Results. This study showed significant differences in a set of 22 anthropometric dimensions regarding gender, age, and ethnicity. Conclusion. According to the results of this study, difference between genders and among different ethnicities should be taken into account by designers and manufacturers of guidance school furniture. Application. This study has prepared a data bank of anthropometric dimensions of 12–14-year-old students which can be used as basic information to find appropriate dimensions of school furniture.

  8. Guidance law based on piecewise constant control for hypersonic gliders

    Science.gov (United States)

    Hull, David G.; Seguin, Jean-Marie

    A midcourse guidance law is developed for the descent of a hypersonic glider to a fixed target on the ground. It is based on an optimal piecewise constant control (N intervals) obtained from an approximate physical model (flat earth, exponential atmosphere, parabolic drag polar, etc). The resulting optimal control equations can be integrated either analytically or by quadrature, and the guidance algorithm requires the solution of 2N+1 nonlinear algebraic equations. The guidance law is implemented in a realistic glider simulation, the intercept is achieved, and final velocities within 14 percent of the true values are obtained for the downrange and crossranges considered.

  9. Descent guidance and mission planning for space shuttle

    Science.gov (United States)

    Joosten, B. K.

    1985-01-01

    The Space Shuttle descent mission planning, mission design, deorbit targeting, and entry guidance have necessarily become interrelated because of the nature of the Orbiter's design and mission requirements. The desired descent trajectory has been formulated in a drag acceleration/relative velocity state space since nearly all of the vehicle's highly constraining flight limitations can be uniquely represented in this plane. Constraints and flight requirements that affect the descent are described. The guidance logic which allows the Orbiter to follow the designed trajectory, the impacts of contingency aborts and flightcrew interaction are discussed. The mission planning and guidance techniques remain essentially unchanged through the Shuttle flight test program and subsequent operational flights.

  10. Guidance on Dependence Assessment in SPAR-H

    Energy Technology Data Exchange (ETDEWEB)

    April M. Whaley

    2012-06-01

    As part of the effort to develop the SPAR-H user guidance, particular attention was paid to the assessment of dependence in order to address user questions about proper application of dependence. This paper presents a discussion of dependence from a psychological perspective and provides guidance on applying this information during the qualitative analysis of dependence to ensure more realistic and appropriate dependence assessments with the SPAR-H method. While this guidance was developed with SPAR-H in mind, it may be informative to other human reliability analysis methods that also use a THERP-based dependence approach, particularly if applied at the human failure event level.

  11. Design of highwall mining equipment electronic guidance package

    Energy Technology Data Exchange (ETDEWEB)

    Brenden, B.B.; Morgen, G.P.; Shorpik, J.R.; Farrar, R.

    1981-11-01

    This report provides design specifics and guidance software for a guidance system intended for use in guiding an auger type highwall mining head through thin coal seams to depths of up to 600 ft. A small desk top computer is used at the operator's station to send and receive signals in serialized bit streams to a downhole microprocessor. The guidance system accepts signals from a variety of sensors and uses these signals to plot and control the course of the auger head automatically using computer algorithms designed to keep the auger head in the coal seam and maintain a specified stump thickness.

  12. European guidance: a project of the European Psychiatric Association.

    Science.gov (United States)

    Gaebel, W; Möller, H-J

    2012-02-01

    Evidence based medicine is a cornerstone of modern medicine including psychiatry. Treatment practice guidelines are nowadays available for guiding mental health care mainly with a focus on specific disorders. Many important clinical situations or problems beyond treatment, however, are lacking proper guidance. It is in this scope that a European Psychiatry Association (EPA) has developed its own program, the European Guidance Project. The present special issue presents six topics out of these series of guidance documents. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  13. RESEARCH OF GUIDANCE TECHNOLOGY FOR ASSEMBLY MODELING IN VIRTUAL ENVIRONMENT

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Technology of movement and knowledge guidance in virtual assembly is presented. The designer can move the mechanical part precisely under the movement guidance. The movement guidance is implemented based on constraint recognition and assembly degree of freedom analysis. A multi-hierarchy knowledge base is built to represent the assembly knowledge and information. The virtual assembly system judges the requirement of the designer based on the context of design task and searches for the useful knowledge and information, which can be provided to the designer in a natural way.

  14. Strapdown Homing Guidance System Design for Some Ammunition

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The strapdown homing guidance system for some ammunition was mainly studied. A strong tracking Kalman filter was designed for the strapdown homing guidance system using the information measured by the strapdown homing seeker to estimate relative movement variables between the ammunition and target. Then the optimal proportional law, which using the estimated information, guided the ammunition. Simulation results show that the designed strapdown homing guidance system with strong tracking Kalman filter can attack the maneuvering target effectively, and satisfy the performance index for the guided ammunition system.

  15. Lifelong guidance: How guidance and counselling support lifelong learning in the contrasting contexts of China and Denmark

    Science.gov (United States)

    Zhang, Zhixin

    2016-10-01

    Due to the effects of globalisation and rapid technological development, traditional linear life course patterns of the past are gradually disappearing, and this affects education and learning systems as well as labour markets. Individuals are forced to develop lifestyles and survival strategies to manage job insecurity and make their skills and interests meet labour market needs. In modern attempts to develop and implement institutional provision for lifelong learning, guidance and counselling play an important role. The current Danish guidance system is well-organised, highly structured and professionalised. By contrast, Chinese guidance is still fragmented and "sectorisational". This paper explores whether elements of the highly structured and professionalised Danish guidance system and practice might be applicable to the Chinese context. The author begins by outlining international and national factors which are affecting citizens' life and career planning. She then presents and discusses the evolution of guidance and the different elements of provision in each of the two countries. Next, She compares the concepts and goals of "lifelong guidance" in Denmark and China, pointing out their similarities and differences and their respective strengths and weaknesses. The paper concludes with some suggestions for the further development of guidance in China.

  16. Lifelong guidance: How guidance and counselling support lifelong learning in the contrasting contexts of China and Denmark

    Science.gov (United States)

    Zhang, Zhixin

    2016-09-01

    Due to the effects of globalisation and rapid technological development, traditional linear life course patterns of the past are gradually disappearing, and this affects education and learning systems as well as labour markets. Individuals are forced to develop lifestyles and survival strategies to manage job insecurity and make their skills and interests meet labour market needs. In modern attempts to develop and implement institutional provision for lifelong learning, guidance and counselling play an important role. The current Danish guidance system is well-organised, highly structured and professionalised. By contrast, Chinese guidance is still fragmented and "sectorisational". This paper explores whether elements of the highly structured and professionalised Danish guidance system and practice might be applicable to the Chinese context. The author begins by outlining international and national factors which are affecting citizens' life and career planning. She then presents and discusses the evolution of guidance and the different elements of provision in each of the two countries. Next, She compares the concepts and goals of "lifelong guidance" in Denmark and China, pointing out their similarities and differences and their respective strengths and weaknesses. The paper concludes with some suggestions for the further development of guidance in China.

  17. Ultrasound guidance system for prostate biopsy

    Science.gov (United States)

    Hummel, Johann; Kerschner, Reinhard; Kaar, Marcus; Birkfellner, Wolfgang; Figl, Michael

    2017-03-01

    We designed a guidance system for prostate biopsy based on PET/MR images and 3D ultrasound (US). With our proposed method common inter-modal MR-US (or CT-US in case of PET/CTs) registration can be replaced by an intra-modal 3D/3D-US/US registration and an optical tracking system (OTS). On the pre-operative site, a PET/MR calibration allows to link both hybrid modalities with an abdominal 3D-US. On the interventional site, another abdominal 3D US is taken to merge the pre-operative images with the real-time 3D-US via 3D/3D-US/US registration. Finally, the images of a tracked trans-rectal US probe can be displayed with the pre-operative images by overlay. For PET/MR image fusion we applied a point-to-point registration between PET and OTS and MR and OTS, respectively. 3D/3D-US/US registration was evaluated for images taken in supine and lateral patient position. To enable table shifts between PET/MR and US image acquisition a table calibration procedure is presented. We found fiducial registration errors of 0.9 mm and 2.8 mm, respectively, with respect to the MR and PET calibration. A target registration error between MR and 3D US amounted to 1.4 mm. The registration error for the 3D/3D-US/US registration was found to be 3.7 mm. Furthermore, we have shown that ultrasound is applicable in an MR environment.

  18. Improved video guidance sensor for automated docking

    Science.gov (United States)

    Howard, Richard T.; Book, Michael L.

    1995-06-01

    The Video Guidance Sensor (VGS) has been developed by NASA's Marshall Space Flight Center (MSFC) to provide the capability for a spacecraft to find and track a target vehicle and determine the relative positions and attitudes between the sensor and the target. The sensor uses laser diodes to illuminate the target, a CCD-based camera to sense the target, and a frame-grabber and processor to convert the video information into relative range, azimuth, elevation, roll, pitch, and yaw. The sensor was first built in 1988 and used in successful automated docking experiments using the air-bearing spacecraft simulator in MSFC's Flight Robotics Laboratory. Since then, many changes and improvements have been made, based on the results of testing. In addition to the use of this system for space vehicles, it has been adapted for commercial application. The current design is being built as a prototype to prepare for flight testing on the Space Shuttle. Some of the changes from the original system were designed to improve the noise rejection of the system. Other changes were made to improve the overall range of operation of the system, and still other changes improved the bandwidth of the system. The current VGS is designed to operate from 110 meters down to 0.5 meters and output the relative position and attitude data at 5 Hz. The system will be able to operate under any orbital lighting conditions from full solar illumination to complete darkness. The VGS is also designed to be used with more than one target and sensor to allow for redundant configurations. This new prototype should be completed and undergoing open- and closed-loop testing after March 1995.

  19. Significant Guidance Issued by the Office of the Secretary of Transportation

    Data.gov (United States)

    Department of Transportation — A list of Significant Guidance documents, which include guidance document disseminated to regulated entities or the general public that may reasonably be anticipated...

  20. Guidance and control of swarms of spacecraft

    Science.gov (United States)

    Morgan, Daniel James

    There has been considerable interest in formation flying spacecraft due to their potential to perform certain tasks at a cheaper cost than monolithic spacecraft. Formation flying enables the use of smaller, cheaper spacecraft that distribute the risk of the mission. Recently, the ideas of formation flying have been extended to spacecraft swarms made up of hundreds to thousands of 100-gram-class spacecraft known as femtosatellites. The large number of spacecraft and limited capabilities of each individual spacecraft present a significant challenge in guidance, navigation, and control. This dissertation deals with the guidance and control algorithms required to enable the flight of spacecraft swarms. The algorithms developed in this dissertation are focused on achieving two main goals: swarm keeping and swarm reconfiguration. The objectives of swarm keeping are to maintain bounded relative distances between spacecraft, prevent collisions between spacecraft, and minimize the propellant used by each spacecraft. Swarm reconfiguration requires the transfer of the swarm to a specific shape. Like with swarm keeping, minimizing the propellant used and preventing collisions are the main objectives. Additionally, the algorithms required for swarm keeping and swarm reconfiguration should be decentralized with respect to communication and computation so that they can be implemented on femtosats, which have limited hardware capabilities. The algorithms developed in this dissertation are concerned with swarms located in low Earth orbit. In these orbits, Earth oblateness and atmospheric drag have a significant effect on the relative motion of the swarm. The complicated dynamic environment of low Earth orbits further complicates the swarm-keeping and swarm-reconfiguration problems. To better develop and test these algorithms, a nonlinear, relative dynamic model with J2 and drag perturbations is developed. This model is used throughout this dissertation to validate the algorithms

  1. Standard deviations

    CERN Document Server

    Smith, Gary

    2015-01-01

    Did you know that having a messy room will make you racist? Or that human beings possess the ability to postpone death until after important ceremonial occasions? Or that people live three to five years longer if they have positive initials, like ACE? All of these ‘facts' have been argued with a straight face by researchers and backed up with reams of data and convincing statistics.As Nobel Prize-winning economist Ronald Coase once cynically observed, ‘If you torture data long enough, it will confess.' Lying with statistics is a time-honoured con. In Standard Deviations, ec

  2. Measure Guideline: Ventilation Guidance for Residential High-Performance New Construction - Multifamily

    Energy Technology Data Exchange (ETDEWEB)

    Lstiburek, Joseph [Building Science Corp., Westford, MA (United States)

    2017-01-01

    The measure guideline provides ventilation guidance for residential high performance multifamily construction that incorporates the requirements of the ASHRAE 62.2 ventilation and indoor air quality standard. The measure guideline focus is on the decision criteria for weighing cost and performance of various ventilation systems. The measure guideline is intended for contractors, builders, developers, designers and building code officials. The guide may also be helpful to building owners wishing to learn more about ventilation strategies available for their buildings. The measure guideline includes specific design and installation instructions for the most cost effective and performance effective solutions for ventilation in multifamily units that satisfies the requirements of ASHRAE 62.2-2016.

  3. Orthogonal Rings, Fiducial Markers, and Overlay Accuracy When Image Fusion is Used for EVAR Guidance.

    Science.gov (United States)

    Koutouzi, G; Sandström, C; Roos, H; Henrikson, O; Leonhardt, H; Falkenberg, M

    2016-11-01

    Evaluation of orthogonal rings, fiducial markers, and overlay accuracy when image fusion is used for endovascular aortic repair (EVAR). This was a prospective single centre study. In 19 patients undergoing standard EVAR, 3D image fusion was used for intra-operative guidance. Renal arteries and targeted stent graft positions were marked with rings orthogonal to the respective centre lines from pre-operative computed tomography (CT). Radiopaque reference objects attached to the back of the patient were used as fiducial markers to detect patient movement intra-operatively. Automatic 3D-3D registration of the pre-operative CT with an intra-operative cone beam computed tomography (CBCT) as well as 3D-3D registration after manual alignment of nearby vertebrae were evaluated. Registration was defined as being sufficient for EVAR guidance if the deviation of the origin of the lower renal artery was less than 3 mm. For final overlay registration, the renal arteries were manually aligned using aortic calcification and vessel outlines. The accuracy of the overlay before stent graft deployment was evaluated using digital subtraction angiography (DSA) as direct comparison. Fiducial markers helped in detecting misalignment caused by patient movement during the procedure. Use of automatic intensity based registration alone was insufficient for EVAR guidance. Manual registration based on vertebrae L1-L2 was sufficient in 7/19 patients (37%). Using the final adjusted registration as overlay, the median alignment error of the lower renal artery marking at pre-deployment DSA was 2 mm (0-5) sideways and 2 mm (0-9) longitudinally, mostly in a caudal direction. 3D image fusion can facilitate intra-operative guidance during EVAR. Orthogonal rings and fiducial markers are useful for visualization and overlay correction. However, the accuracy of the overlaid 3D image is not always ideal and further technical development is needed. Copyright © 2016 European Society for Vascular Surgery

  4. "11th Five Year" Plan on Certification and Accreditation Standardization

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ To strengthen the certification and authorization standardization system, the Certification and Accreditation Administration of China (CNCA), and Standardization Administration of China (SAC)have jointly promulgated the "11th Five Year" Plan on Development of Certification and Accreditation Standardization. In compliance with the "11th Five Year" Plan on Development of Certification and Accreditation Cause and the "11th Five Year" Plan on Development of Standardization,the "11th Five Year"Plan on Development of Certification and Accreditation Standardization provides comprehensive guidance to and basis for the certification and accreditation cause during the "11th Five Year".

  5. NAFTA Guidance Document for Conducting Terrestrial Field Dissipation Studies

    Science.gov (United States)

    Harmonized guidance for TFD studies that demonstrate transformation, transport and fate of pesticides under representative actual use conditions. Field studies substantiate physicochemical, mobility and biotransformation data from laboratory studies.

  6. GNSS TECHNOLOGY DETERMINATION OF FLYING MACHINE GUIDANCE PARAMETERS

    Directory of Open Access Journals (Sweden)

    Valeriy Konin

    2013-10-01

    Full Text Available Normal 0 false false false MicrosoftInternetExplorer4 An algorithm of calculating the guidance parameters for GNSS aircraft landing technology was considered. The simulation and evaluation of calculation parameters error were performed as well

  7. Re-Entry Guidance Using an Energy-State Equation

    Science.gov (United States)

    Abe, Akio; Shimada, Yuzo; Uchiyama, Kenji

    This paper presents a new guidance and control system for a re-entry vehicle. In the conventional drag acceleration control system employed for the present space shuttles, the velocity is an unobservable state variable and the associated pole tends to be unstable. Therefore, in this study, a condition which allows all the states to be observable is introduced using a state-space linearization method. It is also shown that energy and its rate are appropriate for the state variables. A guidance law is analytically derived on the basis of the obtained state equation with respect to the energy by solving a two-point boundary-value problem. Furthermore, a tracking control system is designed to make the position, velocity, and flight path angle of the vehicle track the reference states generated in the guidance system. Finally, numerical simulation is performed to verify the validity of the obtained plant expression, and the effectiveness of the proposed guidance and control system.

  8. 77 FR 19417 - Proposed Guidance on Leveraged Lending

    Science.gov (United States)

    2012-03-30

    ... documenting enterprise value, risk management expectations for credits awaiting distribution, stress testing expectations and portfolio management, and risk management expectations. This proposed guidance would apply to... monitor underwritten credit risks, to understand the effect of changes in borrowers' enterprise...

  9. pedagogical guidance for consumer studies reflected in the south ...

    African Journals Online (AJOL)

    user

    ISSN 0378-5254 Journal of Family Ecology and Consumer Sciences, Vol 43, 2015. Pedagogical guidance .... recommendations in the Ministerial Task Team report (DoE, 2009:62) .... the method and practice/ activities of teaching – specifically ...

  10. New EPA Guidance for Testing Pesticides Will Reduce Animal Testing

    Science.gov (United States)

    EPA is issuing guidance for requesting waivers of acute dermal toxicity testing requirements for pesticide formulations, which will lead to fewer animal tests for acute dermal toxicity for pesticides.

  11. 76 FR 411 - Regulatory Guidance Concerning Electronic Signatures and Documents

    Science.gov (United States)

    2011-01-04

    ... govern the Agency's implementation of electronic document and signature requirements. The Government... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration Regulatory Guidance Concerning Electronic Signatures and...

  12. Guidance and Counselling Services as a Coping Strategy for ...

    African Journals Online (AJOL)

    Toshiba

    summarizes the definition of guidance and counselling as Research on. Humanities and ... climate of freedom from fear, intimidation and harassment, oppression .... enables them to be prepared to take actions within organizational context.

  13. Haptic guidance improves the visuo-manual tracking of trajectories

    CERN Document Server

    Bluteau, Jérémy; Payan, Yohan; Gentaz, Edouard

    2008-01-01

    BACKGROUND: Learning to perform new movements is usually achieved by following visual demonstrations. Haptic guidance by a force feedback device is a recent and original technology which provides additional proprioceptive cues during visuo-motor learning tasks. The effects of two types of haptic guidances-control in position (HGP) or in force (HGF)-on visuo-manual tracking ("following") of trajectories are still under debate. METHODOLOGY/PRINCIPALS FINDINGS: Three training techniques of haptic guidance (HGP, HGF or control condition, NHG, without haptic guidance) were evaluated in two experiments. Movements produced by adults were assessed in terms of shapes (dynamic time warping) and kinematics criteria (number of velocity peaks and mean velocity) before and after the training sessions. CONCLUSION/SIGNIFICANCE: These results show that the addition of haptic information, probably encoded in force coordinates, play a crucial role on the visuo-manual tracking of new trajectories.

  14. Educational and Career Guidance for Adults: Delivery System Alternatives.

    Science.gov (United States)

    Darkenwald, Gordon G.

    1980-01-01

    Discusses the need for guidance and information services to help adults make educational and career choices, from an organizational and administrative perspective. Major innovations are needed in educational delivery systems for the adult public. Federal legislation can help. (JAC)

  15. Triangle Interception Scenario: A Finite-Time Guidance Approach

    Directory of Open Access Journals (Sweden)

    Yang Guo

    2016-01-01

    Full Text Available Considering an aircraft threatened by an interceptor, one of the effective penetration strategies is to release a Defender from the aircraft to confront the interceptor. In this case, the aircraft, the Defender, and the interceptor constitute the three-body guidance relationship, and the cooperation of the aircraft and its Defender to achieve the best tactical effects turns into a concerned problem. This paper studies the triangle interception guidance problem via the finite-time theory. The paper presents linear system Input-Output Finite-Time Stabilization (IO-FTS method. The sufficient conditions of the linear system, being IO-FTS, under Finite-Time Boundedness (FTB constraint are proposed, by which the state feedback controllers design method is obtained, via Linear Matrix Inequalities (LMIs. The triangle interception guidance problems are studied in three different cases, where the proposed methods are applied to the guidance design. The simulation results illustrate the effectiveness of the proposed methods.

  16. 78 FR 29159 - Electric Power Research Institute; Seismic Evaluation Guidance

    Science.gov (United States)

    2013-05-17

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Electric Power Research Institute; Seismic Evaluation Guidance AGENCY: Nuclear Regulatory... issuing an endorsement letter of Electric Power Research Institute (EPRI) Report, ``Seismic...

  17. United Nations Environment Program - Sustainable Purchasing Guidance Profile

    Science.gov (United States)

    To help you find the resource that is right for your organization, EPA conducted a scan of the landscape and developed summary profiles of some of the leading sources of sustainable purchasing guidance around the globe.

  18. FDA Offers Guidance on Fish Intake for Kids, Pregnant Women

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_163113.html FDA Offers Guidance on Fish Intake for Kids, Pregnant ... is far less than the recommended amount, the FDA said. Fish offers nutritional benefits important for growth ...

  19. the role of guidance counsellors in universal basic education school ...

    African Journals Online (AJOL)

    Emeka Egbochuku

    This monograph on the role of guidance counsellors in School Based Assessment of Universal ... 2010) without achieving some of its objectives like skill acquisition for self ..... Non utilization of summative and cumulative assessment feedback.

  20. An analysis of Educational Guidance in Training of civil Engineering

    Directory of Open Access Journals (Sweden)

    Ibette Alfonso Pérez

    2013-06-01

    Full Text Available The work shows an analysis of educational guidance realized by the first year of Civil Engineeringcareer in Cujae. The authors expose basics ideas in relation with the study of literature related to thistopic, for establish specific ideas of university educational guidance. Besides, this work presents theanalysis of educational guidance received by two groups of students of first year during a course2010-2011. It´s employed reflective and open techniques since an interpretive perspective andpredominantly qualitative methodological framework. We have concluded that not enough educationalguidance realized by students during training process, because it´s essential to increase the quantityof actions for guidance and to get these ones integrate the substantive university processes. In thismanner, the teachers can guide the student in your satisfactory transit for the university.

  1. EXPERIENCE OF USING WEBINARS ON CAREER GUIDANCE AMONG THE APPLICANTS

    National Research Council Canada - National Science Library

    Vitalii S. Mosiichuk; Nataliia N. Rudenko; Ihor V. Protsko

    2014-01-01

    This article describes the experience of career guidance to students using ICT. Technical features of conducting webinars in order to allow the participation of the maximum number of participants are disclosed...

  2. CT-Analyst GIS Data Processing Guidance Document

    Science.gov (United States)

    2014-04-30

    Naval Research Laboratory Washington, DC 20375-5320 NRL/MR/6040--14-9480 CT-Analyst GIS Data Processing Guidance Document April 30, 2014 Approved...NUMBER (include area code) b. ABSTRACT c. THIS PAGE 18. NUMBER OF PAGES 17. LIMITATION OF ABSTRACT CT-Analyst GIS Data Processing Guidance Document Adam...Information File 7 3) Gathering GIS Data 8 1. Explanation 8 2. Coordinate Systems 8 3. Typical File Types 9 1

  3. WIPP waste characterization program sampling and analysis guidance manual

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    The Waste Isolation Pilot Plant (WIPP) Waste Characterization Program Sampling and Analysis Guidance Manual (Guidance Manual) provides a unified source of information on the sampling and analytical techniques that enable Department of Energy (DOE) facilities to comply with the requirements established in the current revision of the Quality Assurance Program Plan (QAPP) for the WIPP Experimental-Waste Characterization Program (the Program). This Guidance Manual includes all of the sampling and testing methodologies accepted by the WIPP Project Office (DOE/WPO) for use in implementing the Program requirements specified in the QAPP. This includes methods for characterizing representative samples of transuranic (TRU) wastes at DOE generator sites with respect to the gas generation controlling variables defined in the WIPP bin-scale and alcove test plans, as well as waste container headspace gas sampling and analytical procedures to support waste characterization requirements under the WIPP test program and the Resource Conservation and Recovery Act (RCRA). The procedures in this Guidance Manual are comprehensive and detailed and are designed to provide the necessary guidance for the preparation of site specific procedures. The use of these procedures is intended to provide the necessary sensitivity, specificity, precision, and comparability of analyses and test results. The solutions to achieving specific program objectives will depend upon facility constraints, compliance with DOE Orders and DOE facilities' operating contractor requirements, and the knowledge and experience of the TRU waste handlers and analysts. With some analytical methods, such as gas chromatography/mass spectrometry, the Guidance Manual procedures may be used directly. With other methods, such as nondestructive/destructive characterization, the Guidance Manual provides guidance rather than a step-by-step procedure.

  4. An intelligent guidance and control system for ship obstacle avoidance

    OpenAIRE

    Harris, C J; Hong, X.; Wilson, P. A.

    1999-01-01

    An intelligent guidance and control system using a neurofuzzy network multistep ahead predictor model is introduced and applied to ship obstacle avoidance, which uses only observed input/output data generated by on board and external sensors, and a data fusion algorithm to generate the desired waypoints. A simple and effective waypoint guidance scheme based on line-of-sight is derived for a data based ship model. A neurofuzzy network predictor, based on using rudder deflection angle for the c...

  5. Saudi dental students’ perceptions of pediatric behavior guidance techniques

    OpenAIRE

    Al-Jobair, Asma M; Al-Mutairi, Manal A.

    2015-01-01

    Background Dental students receive theoretical and clinical training in pediatric behavioral guidance techniques at university. Therefore, the content of the educational course and the degree of training in behavioral techniques may have an impact on the students’ perceptions and practice of such techniques. The purpose of this study was to evaluate Saudi dental students’ perceptions of behavior guidance techniques used in pediatric dentistry, and to assess the changes in their perceptions af...

  6. Motor learning with fading and growing haptic guidance.

    Science.gov (United States)

    Heuer, Herbert; Lüttgen, Jenna

    2014-07-01

    Haptic guidance has been shown to have both facilitatory and interfering effects on motor learning. Interfering effects have been hypothesized to result from the particular dynamic environment, which supports a passive role of the learner, and they should be attenuated by fading guidance. Facilitatory effects, in particular for dynamic movement characteristics, have been hypothesized to result from the high-quality information provided by haptic demonstration. If haptic demonstration provides particularly precise information about target movements, the motor system's need for such information should more likely increase in the course of motor learning, in which case growing guidance should be more beneficial for learning. We contrasted fading and growing guidance in the course of learning a spatio-temporal motor pattern. To stimulate an active role of the learner, practice trials consisted of three phases, a visual demonstration of the target movement, a guided reproduction, and a reproduction without haptic guidance. Performance was assessed in terms of variable duration errors, relative-timing errors, variable path-length errors, and shape errors. Motor learning with growing and fading guidance turned out to be largely equivalent, so that the notion of an increasing optimal precision of haptic demonstrations, which matches a demand of increasingly precise information on the target movement, found no support. Duration errors declined only with fading, but not with growing guidance. Relative timing revealed a benefit of immediately preceding haptic demonstration, but learning was not different between the two practice protocols. This contrast between absolute and relative timing adds to other evidence according to which acquisition of these two aspects of motor timing involves different learning mechanisms. Whereas relative timing gained from immediately preceding haptic demonstration, but revealed no practice-related improvement in the presence of haptic guidance

  7. Improving Software Guidance for Technology Readiness Assessments (TRA)

    Science.gov (United States)

    2010-04-29

    Systems & Software Technology Conference Improving Software Guidance for Technology Readiness Assessments (TRA) 29 April 2010 Mike Nicol...APR 2010 2. REPORT TYPE 3. DATES COVERED 00-00-2010 to 00-00-2010 4. TITLE AND SUBTITLE Improving Software Guidance for Technology Readiness...Presented at the 22nd Systems and Software Technology Conference (SSTC), 26-29 April 2010, Salt Lake City, UT. 14. ABSTRACT 15. SUBJECT TERMS

  8. Health information literacy required for teachers in health guidance

    OpenAIRE

    古田, 真司

    2012-01-01

    In order to perform scientific health guidance in school, teachers need to have “health information literacy.”Teachers with health information literacy can collect and analyze health information, examine the information critically, and apply useful findings from the information to health guidance. The most important word for understanding health information literacy is “Evidence,” and the method of the study guarantees the scientific rationality of “Evidence” in the study. In classifying evid...

  9. Health and thermal comfort : from WHO guidance to housing strategies

    OpenAIRE

    Ormandy, David; Ezratty, Véronique

    2012-01-01

    There are many references to the WHO guidance on thermal comfort in housing, but not to the original source material. Based on archive material, this paper gives the evidential basis for the WHO guidance. It then reports on evidence that some groups may be more susceptible to high or low indoor temperatures than others. It examines different methods for measuring thermal comfort, such as air temperature measurement, assessing residents' perception, and predicting satisfaction. Resident's perc...

  10. Catalogue for the Guidance of Foreign Investment Industries Published

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Approved by the State Council on December 24, 2011, National Development and Reform Commission and Ministry of Commerce promulgated the Catalogue for the Guidance of Foreign Investment Industries (Amended in 2011), which will be implemented on January 30, 2012. Meanwhile, the Catalogue for the Guidance of Foreign Investment Industries (Amended in 2007) promulgated by National Development and Reform Commission and Ministry of Commerce on October 31, 2007 was abolished.

  11. Optimal sliding guidance algorithm for Mars powered descent phase

    Science.gov (United States)

    Wibben, Daniel R.; Furfaro, Roberto

    2016-02-01

    Landing on large planetary bodies (e.g. Mars) with pinpoint accuracy presents a set of new challenges that must be addressed. One such challenge is the development of new guidance algorithms that exhibit a higher degree of robustness and flexibility. In this paper, the Zero-Effort-Miss/Zero-Effort-Velocity (ZEM/ZEV) optimal sliding guidance (OSG) scheme is applied to the Mars powered descent phase. This guidance algorithm has been specifically designed to combine techniques from both optimal and sliding control theories to generate an acceleration command based purely on the current estimated spacecraft state and desired final target state. Consequently, OSG yields closed-loop trajectories that do not need a reference trajectory. The guidance algorithm has its roots in the generalized ZEM/ZEV feedback guidance and its mathematical equations are naturally derived by defining a non-linear sliding surface as a function of the terms Zero-Effort-Miss and Zero-Effort-Velocity. With the addition of the sliding mode and using Lyapunov theory for non-autonomous systems, one can formally prove that the developed OSG law is globally finite-time stable to unknown but bounded perturbations. Here, the focus is on comparing the generalized ZEM/ZEV feedback guidance with the OSG law to explicitly demonstrate the benefits of the sliding mode augmentation. Results show that the sliding guidance provides a more robust solution in off-nominal scenarios while providing similar fuel consumption when compared to the non-sliding guidance command. Further, a Monte Carlo analysis is performed to examine the performance of the OSG law under perturbed conditions.

  12. Career guidance for Social Justice in Neo-Liberal Times

    DEFF Research Database (Denmark)

    Thomsen, Rie; Skovhus, Randi Boelskifte; Sultana, Ronald

    SIMPOSIO 16. Career guidance for Social Justice in Neo-Liberal Times (English) Ronald Sultana (Coord.), Tristram Hooley (Coord.), Rie Thomsen, Peter Plant, Roger Kjærgård, Marcelo Afonso Ribeiro, Randi Boelskifte Skovhus and Tron Inglar......SIMPOSIO 16. Career guidance for Social Justice in Neo-Liberal Times (English) Ronald Sultana (Coord.), Tristram Hooley (Coord.), Rie Thomsen, Peter Plant, Roger Kjærgård, Marcelo Afonso Ribeiro, Randi Boelskifte Skovhus and Tron Inglar...

  13. Preventing deformational plagiocephaly through parent guidance: a randomized, controlled trial.

    Science.gov (United States)

    Aarnivala, Henri; Vuollo, Ville; Harila, Virpi; Heikkinen, Tuomo; Pirttiniemi, Pertti; Valkama, A Marita

    2015-09-01

    Deformational plagiocephaly (DP) occurs frequently in otherwise healthy infants. Many infants with DP undergo physiotherapy or helmet therapy, and ample treatment-related research is available. However, the possibility of preventing DP has been left with little attention. We sought to evaluate the effectiveness of intervention in the newborn's environment, positioning, and handling on the prevalence of DP at 3 months and to investigate the causal relationship between DP and cervical imbalance. We carried out a randomized controlled trial, with healthy newborns randomized into two groups at birth. All families received standard positioning instructions to prevent SIDS. Additionally, the intervention group received detailed instructions regarding the infant's environment, positioning, and handling, with the goal of creating a nonrestrictive environment that promotes spontaneous physical movement and symmetrical motor development. Two- and three-dimensional photogrammetry served to assess cranial shape and goniometry to measure cervical motion. At 3 months, the prevalence of DP was lower in the intervention group in both 2D (11 vs 31 %) and 3D analyses (15 vs 33 %), and the asymmetry was milder in the intervention group. Infants with DP at follow-up had also developed more torticollis. An early educational intervention reduces the prevalence and severity of DP at 3 months. •Deformational plagiocephaly, often with associated torticollis, is common in healthy infants. •Parental education is frequently recommended for preventing deformational plagiocephaly, although information regarding the effectiveness of preventive strategies is scarce. •Early parent guidance effectively reduces the prevalence and severity of DP and improves the cervical range of motion at three months. •Educating both parents and professionals about proper infant positioning on a national scale could help minimize public healthcare costs.

  14. Guidance on risk analysis and safety implications of a large liquefied natural gas (LNG) spill over water.

    Energy Technology Data Exchange (ETDEWEB)

    Wellman, Gerald William; Melof, Brian Matthew; Luketa-Hanlin, Anay Josephine; Hightower, Marion Michael; Covan, John Morgan; Gritzo, Louis Alan; Irwin, Michael James; Kaneshige, Michael Jiro; Morrow, Charles W.

    2004-12-01

    While recognized standards exist for the systematic safety analysis of potential spills or releases from LNG (Liquefied Natural Gas) storage terminals and facilities on land, no equivalent set of standards or guidance exists for the evaluation of the safety or consequences from LNG spills over water. Heightened security awareness and energy surety issues have increased industry's and the public's attention to these activities. The report reviews several existing studies of LNG spills with respect to their assumptions, inputs, models, and experimental data. Based on this review and further analysis, the report provides guidance on the appropriateness of models, assumptions, and risk management to address public safety and property relative to a potential LNG spill over water.

  15. 75 FR 60616 - Commission Guidance Regarding Auditing, Attestation, and Related Professional Practice Standards...

    Science.gov (United States)

    2010-10-01

    ... example, states that the audit of the report required by Rule 17a-5(d) ``* * * shall be made in accordance... Exchange Act requires that the audit of certain over-the-counter derivative dealers ``* * * shall be made... Commission is considering a rulemaking project to update the audit and related attestation requirements under...

  16. Technical Guidance for Conducting ASVAB Validation/Standards Studies in the U.S. Navy

    Science.gov (United States)

    2015-02-01

    technology, psychology, and health) (pp. 316-336). Santa Barbara , CA: Greenwood. Wise, L., Welsh, J., Grafton, F., Foley, P., Earles, J., Sawin, L., & Divgi...outcomes. A Navy-developed model called the Cost of Attaining Personnel Requirements ( CAPER ) incorporated the Taylor-Russell (1939) tables discussed in...Chapters 3 and 17. The CAPER model takes into account the magnitude of the validity coefficient and includes the following factors: Quota = # of

  17. Army Implementation of DoD and Federal Standards. Volume 2. Implementation Guidance.

    Science.gov (United States)

    1988-05-06

    Recommendations of The Series I. Integrated Digital Services Network. NOTE In Table 3.1 are CCITT RED BOOK Recommendations for ISDN, carried to the...Integrated Digital Services Network for the purpose of providing a single integrated common-user communication system. 5.1.2 Requirements. The vendor

  18. G-Guidance Interface Design for Small Body Mission Simulation

    Science.gov (United States)

    Acikmese, Behcet; Carson, John; Phan, Linh

    2008-01-01

    The G-Guidance software implements a guidance and control (G and C) algorithm for small-body, autonomous proximity operations, developed under the Small Body GN and C task at JPL. The software is written in Matlab and interfaces with G-OPT, a JPL-developed optimization package written in C that provides G-Guidance with guaranteed convergence to a solution in a finite computation time with a prescribed accuracy. The resulting program is computationally efficient and is a prototype of an onboard, real-time algorithm for autonomous guidance and control. Two thruster firing schemes are available in G-Guidance, allowing tailoring of the software for specific mission maneuvers. For example, descent, landing, or rendezvous benefit from a thruster firing at the maneuver termination to mitigate velocity errors. Conversely, ascent or separation maneuvers benefit from an immediate firing to avoid potential drift toward a second body. The guidance portion of this software explicitly enforces user-defined control constraints and thruster silence times while minimizing total fuel usage. This program is currently specialized to small-body proximity operations, but the underlying method can be generalized to other applications.

  19. Trajectory reshaping based guidance with impact time and angle constraints

    Institute of Scientific and Technical Information of China (English)

    Zhao Yao; Sheng Yongzhi; Liu Xiangdong

    2016-01-01

    This study presents a novel impact time and angle constrained guidance law for homing missiles. The guidance law is first developed with the prior-assumption of a stationary target, which is followed by the practical extension to a maneuvering target scenario. To derive the closed-form guidance law, the trajectory reshaping technique is utilized and it results in defining a specific poly-nomial function with two unknown coefficients. These coefficients are determined to satisfy the impact time and angle constraints as well as the zero miss distance. Furthermore, the proposed guidance law has three additional guidance gains as design parameters which make it possible to adjust the guided trajectory according to the operational conditions and missile’s capability. Numerical simulations are presented to validate the effectiveness of the proposed guidance law. © 2016 Chinese Society of Aeronautics and Astronautics. Production and hosting by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

  20. Guidance on Nanomaterial Hazards and Risks

    Science.gov (United States)

    2015-05-21

    Staining in Tissue; Fibrot ic Gene Expression Analysis TGF-b, MMPs, TIMPs in BAL fluid; RNA-Ana lysis and RT-PCR Array in Tissue To scr een for...silver), silicon carbide; nanoclays; a mixed metal oxide, lithium titanate, and Arizona road dust (an internal standard to verify the operation of the...process include the handling of the dry powder form of the ENM, the mixing or sonication of a suspension containing ENM, or the cutting, grinding or other

  1. International Conference on Harmonisation; guidance on S2(R1) Genotoxicity Testing and Data Interpretation for Pharmaceuticals intended for Human Use; availability. Notice.

    Science.gov (United States)

    2012-06-07

    The Food and Drug Administration (FDA) is announcing the availability of a guidance entitled ``S2(R1) Genotoxicity Testing and Data Interpretation for Pharmaceuticals Intended for Human Use'' (ICH S2(R1)). This guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The ICH S2(R1) combines and replaces two ICH guidances, "S2A Specific Aspects for Regulatory Genotoxicity Tests for Pharmaceuticals'' and "S2B Genotoxicity: A Standard Battery for Genotoxicity Testing of Pharmaceuticals.'' ICH S2(R1) provides guidance to drug sponsors on which tests should be performed to assess potential genotoxicity of pharmaceuticals. It also provides guidance on testing conditions, data interpretation, and followup strategies if a positive response is seen in in vitro assays. This guidance is intended to provide drug sponsors with recommendations to ensure that drugs are appropriately tested for potential to cause genetic damage and to ensure efficient development of new drugs.

  2. Standard guide for sampling radioactive tank waste

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2011-01-01

    1.1 This guide addresses techniques used to obtain grab samples from tanks containing high-level radioactive waste created during the reprocessing of spent nuclear fuels. Guidance on selecting appropriate sampling devices for waste covered by the Resource Conservation and Recovery Act (RCRA) is also provided by the United States Environmental Protection Agency (EPA) (1). Vapor sampling of the head-space is not included in this guide because it does not significantly affect slurry retrieval, pipeline transport, plugging, or mixing. 1.2 The values stated in inch-pound units are to be regarded as standard. No other units of measurement are included in this standard. 1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

  3. Environmental guidance for public participation in environmental restoration activities

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-01

    The US Department of Energy (DOE) is issuing this document, entitled Guidance on Public Participation for US Department of Energy Environmental Restoration Activities, to summarize policy and provide guidance for public participation in environmental restoration activities at DOE Headquarters, Field Offices, facilities, and laboratories. While the Office of Environmental Restoration and Waste Management (EM) has environmental restoration responsibility for the majority of DOE sites and facilities, other DOE Project Offices have similar responsibilities at their sites and facilities. This guidance is applicable to all environment restoration activities conducted by or for DOE under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA); the Resource Conservation and Recovery Act of 1976 (RCRA) as amended by the Hazardous and Solid Waste Amendments of 1984 (HSWA) (corrective actions only); and the National Environmental Policy Act of 1969 (NEPA). This guidance also is applicable to CERCLA remedial action programs under the Uranium Mill Tailings Radiation Control Act of 1978 and the Formerly Utilized Sites Remedial Action Program, where DOE is the designated lead. The primary objectives of this guidance document are as follows: acclimate DOE staff to a changing culture that emphasizes the importance of public participation activities; provide direction on implementing these public participation activities; and, provide consistent guidance for all DOE Field Offices and facilities. The purpose of this document is to provide guidance on conducting effective public participation activities for environmental restoration activities under CERCLA; RCRA corrective actions under sections 3004(u), 3004(v), and 3008(h); and NEPA public participation activities.

  4. 78 FR 68101 - Environmental Issues Associated With New Reactors and Specific Environmental Guidance for...

    Science.gov (United States)

    2013-11-13

    ... COMMISSION Environmental Issues Associated With New Reactors and Specific Environmental Guidance for Integral..., ``Interim Staff Guidance on Environmental Issues Associated with New Reactors'' and draft ISG ESP/ COL-ISG-027, ``Interim Staff Guidance on Specific Environmental Guidance for iPWR Reviews.'' The purpose...

  5. 76 FR 49772 - Guidance for Industry: Bar Code Label Requirements-Questions and Answers; Availability

    Science.gov (United States)

    2011-08-11

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry: Bar Code Label Requirements... Industry: Bar Code Label Requirements--Questions and Answers'' dated August 2011. The guidance announced in... finalizes the draft guidance entitled ``Guidance for Industry: Bar Code Label Requirements--Questions and...

  6. 75 FR 70254 - PSD and Title V Permitting Guidance for Greenhouse Gases

    Science.gov (United States)

    2010-11-17

    ... AGENCY PSD and Title V Permitting Guidance for Greenhouse Gases AGENCY: Environmental Protection Agency... the EPA has posted its guidance titled, ``PSD and Title V Permitting Guidance for Greenhouse Gases... for Greenhouse Gases.'' This document has been determined to be an EPA Significant Guidance...

  7. 77 FR 60126 - Guidance for Industry on Acute Bacterial Otitis Media: Developing Drugs for Treatment; Availability

    Science.gov (United States)

    2012-10-02

    ...; Formerly 2008N-0004] Guidance for Industry on Acute Bacterial Otitis Media: Developing Drugs for Treatment... Administration (FDA) is announcing the availability of a guidance for industry entitled ``Acute Bacterial Otitis... treatment of acute bacterial otitis media (ABOM). This guidance finalizes the revised draft guidance of the...

  8. Results-Based Guidance: A Systems Approach to Student Support Programs.

    Science.gov (United States)

    Johnson, Sharon; Johnson, Clarence D.

    2003-01-01

    Describes results-based guidance, a systems approach to student support programs. Outlines factors that have contributed to the changes in the duties and responsibilities of guidance counselors and the basis of the competency-based approach in guidance counseling. Details elements of the results-based guidance program. (GCP)

  9. 76 FR 55390 - Guidance on Exculpatory Language in Informed Consent, Draft

    Science.gov (United States)

    2011-09-07

    ... HUMAN SERVICES Guidance on Exculpatory Language in Informed Consent, Draft AGENCY: Office for Human... the availability of a draft guidance entitled, ``Guidance on Exculpatory Language in Informed Consent.'' The draft guidance, when finalized, will represent OHRP's and FDA's current thinking on this topic...

  10. 75 FR 35492 - Guidance for Industry on Lupus Nephritis Caused By Systemic Lupus Erythematosus-Developing...

    Science.gov (United States)

    2010-06-22

    ... availability of a guidance for industry entitled ``Lupus Nephritis Caused By Systemic Lupus Erythematosus... nephritis (LN) caused by systemic lupus erythematosus (SLE). This guidance finalizes the parts of the draft guidance entitled ``Systemic Lupus Erythematosus--Developing Drugs for Treatment'' (the draft guidance...

  11. The Perceived Role of Technology in Career Guidance among Practitioners Who Are Experienced Internet Users

    Science.gov (United States)

    Vuorinen, Raimo; Sampson, James P.; Kettunen, Jaana

    2011-01-01

    The increasing use of technology is placing new demands on career guidance practitioners. This article examines what changes, if any, have occurred in the perceptions of guidance practitioners regarding their role and the role of the internet in meeting guidance goals and delivering career guidance services. The data were collected in focus groups…

  12. 75 FR 24718 - Guidance for Industry on Documenting Statistical Analysis Programs and Data Files; Availability

    Science.gov (United States)

    2010-05-05

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry on Documenting Statistical Analysis... guidance entitled ``Draft Guidance for Industry on Documenting Statistical Analysis Programs and Data Files...: The Food and Drug Administration (FDA) is announcing the availability of a guidance for industry...

  13. Quantitative Decision Support Requires Quantitative User Guidance

    Science.gov (United States)

    Smith, L. A.

    2009-12-01

    Is it conceivable that models run on 2007 computer hardware could provide robust and credible probabilistic information for decision support and user guidance at the ZIP code level for sub-daily meteorological events in 2060? In 2090? Retrospectively, how informative would output from today’s models have proven in 2003? or the 1930’s? Consultancies in the United Kingdom, including the Met Office, are offering services to “future-proof” their customers from climate change. How is a US or European based user or policy maker to determine the extent to which exciting new Bayesian methods are relevant here? or when a commercial supplier is vastly overselling the insights of today’s climate science? How are policy makers and academic economists to make the closely related decisions facing them? How can we communicate deep uncertainty in the future at small length-scales without undermining the firm foundation established by climate science regarding global trends? Three distinct aspects of the communication of the uses of climate model output targeting users and policy makers, as well as other specialist adaptation scientists, are discussed. First, a brief scientific evaluation of the length and time scales at which climate model output is likely to become uninformative is provided, including a note on the applicability the latest Bayesian methodology to current state-of-the-art general circulation models output. Second, a critical evaluation of the language often employed in communication of climate model output, a language which accurately states that models are “better”, have “improved” and now “include” and “simulate” relevant meteorological processed, without clearly identifying where the current information is thought to be uninformative and misleads, both for the current climate and as a function of the state of the (each) climate simulation. And thirdly, a general approach for evaluating the relevance of quantitative climate model output

  14. Guidance and Control of Position and Attitude for Rendezvous and Dock/Berthing with a Noncooperative/Target Spacecraft

    Directory of Open Access Journals (Sweden)

    Gilberto Arantes

    2014-01-01

    Full Text Available Noncooperative target spacecrafts are those assets in orbit that cannot convey any information about their states (position, attitude, and velocities or facilitate rendezvous and docking/berthing (RVD/B process. Designing a guidance, navigation, and control (GNC module for the chaser in a RVD/B mission with noncooperative target should be inevitably solved for on-orbit servicing technologies. The proximity operations and the guidance for achieving rendezvous problems are addressed in this paper. The out-of-plane maneuvers of proximity operations are explored with distinct subphases, including a chaser far approach in the target’s orbit to the first hold point and a closer approach to the final berthing location. Accordingly, guidance solutions are chosen for each subphase from the standard Hill based Closhessy-Willtshire (CW solution, elliptical fly-around, and Glideslope algorithms. The control is based on a linear quadratic regulator approach (LQR. At the final berthing location, attitude tracker based on a proportional derivative (PD form is tested to synchronize the chaser and target attitudes. The paper analyzes the performance of both controllers in terms of the tracking ability and the robustness. Finally, it prescribes any restrictions that may be imposed on the guidance during any subphase which can help to improve the controllers tracking ability.

  15. Stereotactic radiosurgery for intradural spine tumors using cone-beam CT image guidance.

    Science.gov (United States)

    Monserrate, Andrés; Zussman, Benjamin; Ozpinar, Alp; Niranjan, Ajay; Flickinger, John C; Gerszten, Peter C

    2017-01-01

    OBJECTIVE Cone-beam CT (CBCT) image guidance technology has been widely adopted for spine radiosurgery delivery. There is relatively little experience with spine radiosurgery for intradural tumors using CBCT image guidance. This study prospectively evaluated a series of intradural spine tumors treated with radiosurgery. Patient setup accuracy for spine radiosurgery delivery using CBCT image guidance for intradural spine tumors was determined. METHODS Eighty-two patients with intradural tumors were treated and prospectively evaluated. The positioning deviations of the spine radiosurgery treatments in patients were recorded. Radiosurgery was delivered using a linear accelerator with a beam modulator and CBCT image guidance combined with a robotic couch that allows positioning correction in 3 translational and 3 rotational directions. To measure patient movement, 3 quality assurance CBCTs were performed and recorded in 30 patients: before, halfway, and after the radiosurgery treatment. The positioning data and fused images of planning CT and CBCT from the treatments were analyzed to determine intrafraction patient movements. From each of 3 CBCTs, 3 translational and 3 rotational coordinates were obtained. RESULTS The radiosurgery procedure was successfully completed for all patients. Lesion locations included cervical (22), thoracic (17), lumbar (38), and sacral (5). Tumor histologies included schwannoma (27), neurofibromas (18), meningioma (16), hemangioblastoma (8), and ependymoma (5). The mean prescription dose was 17 Gy (range 12-27 Gy) delivered in 1-3 fractions. At the halfway point of the radiation, the translational variations and standard deviations were 0.4 ± 0.5, 0.5 ± 0.8, and 0.4 ± 0.5 mm in the lateral (x), longitudinal (y), and anteroposterior (z) directions, respectively. Similarly, the variations immediately after treatment were 0.5 ± 0.4, 0.5 ± 0.6, and 0.6 ± 0.5 mm along x, y, and z directions, respectively. The mean rotational angles were 0

  16. RAMESES publication standards: realist syntheses

    Directory of Open Access Journals (Sweden)

    Wong Geoff

    2013-01-01

    sources to develop and draw together evidence and expertise in realist synthesis. For each item we have included an explanation for why it is important and guidance on how it might be reported. Realist synthesis is a relatively new method for evidence synthesis and as experience and methodological developments occur, we anticipate that these standards will evolve to reflect further methodological developments. We hope that these standards will act as a resource that will contribute to improving the reporting of realist syntheses. To encourage dissemination of the RAMESES publication standards, this article is co-published in the Journal of Advanced Nursing and is freely accessible on Wiley Online Library (http://www.wileyonlinelibrary.com/journal/jan. Please see related article http://www.biomedcentral.com/1741-7015/11/20 and http://www.biomedcentral.com/1741-7015/11/22

  17. Journal standards.

    Science.gov (United States)

    Jackson, R

    2003-08-01

    Despite its many imperfections, the peer review process is a firmly established quality control system for scientific literature. It gives readers some assurance that the work and views that are reported meet standards that are acceptable to a journal. Maureen Revington's editorial in a recent issue of the Australian Veterinary Journal (Revington2002) gives a good concise warts and all overview of the process and is well worth reading. I have some concerns about several articles in the December 2002 issue of the New Zealand Veterinary Journal (Volume 50, Number 6), devoted to the health and welfare of farmed deer, that relate to extensive citing of non-peer reviewed papers. I can understand the need for information to flow from researchers to the wider community but that need is already satisfied by publications such as the proceedings of the Deer Branch of the New Zealand Veterinary Association and Proceedings of the New Zealand Society of Animal Production. Non-peer reviewed papers have been cited in the Journal in the past but never to the extent displayed in this particular issue. It degrades the peer-review process and creates an added burden for reviewers who are forced to grapple with the uncertainties of the science in non-peer reviewed citations. One of my fears is that this process allows science from non peer reviewed articles to be legitimised by its inclusion in a peer reviewed journal and perhaps go on to be accepted as dogma. This is a real danger given the difficulties associated with tracing back to original citations and the increasing volume of scientific literature. It also affords opportunities for agencies to pick up questionable and doubtful science and tout it as support for their products or particular points of view. If deer researchers choose to publish most of their work in proceedings then so be it. However this approach, which seems to becoming increasingly prevalent in the deer sector, is questionable from an established science point

  18. Guidance Compliance Behavior on VMS Based on SOAR Cognitive Architecture

    Directory of Open Access Journals (Sweden)

    Shiquan Zhong

    2012-01-01

    Full Text Available SOAR is a cognitive architecture named from state, operator and result, which is adopted to portray the drivers' guidance compliance behavior on variable message sign (VMS in this paper. VMS represents traffic conditions to drivers by three colors: red, yellow, and green. Based on the multiagent platform, SOAR is introduced to design the agent with the detailed description of the working memory, long-term memory, decision cycle, and learning mechanism. With the fixed decision cycle, agent transforms state through four kinds of operators, including choosing route directly, changing the driving goal, changing the temper of driver, and changing the road condition of prediction. The agent learns from the process of state transformation by chunking and reinforcement learning. Finally, computerized simulation program is used to study the guidance compliance behavior. Experiments are simulated many times under given simulation network and conditions. The result, including the comparison between guidance and no guidance, the state transition times, and average chunking times are analyzed to further study the laws of guidance compliance and learning mechanism.

  19. How navigational guidance systems are combined in a desert ant.

    Science.gov (United States)

    Collett, Matthew

    2012-05-22

    Animals use information from multiple sources in order to navigate between goals. Ants such as Cataglyphis fortis use an odometer and a sun-based compass to provide input for path integration (PI). They also use configurations of visual features to learn both goal locations and habitual routes to the goals. Information is not combined into a unified representation but appears to be exploited by separate expert guidance systems. Visual and PI goal memories are acquired rapidly and provide the consistency for route memories to be formed. Do established route memories then suppress the guidance from PI? A series of manipulations putting PI and route memories into varying levels of conflict found that ants follow compromise trajectories. The guidance systems are therefore active together and share the control of behavior. Route memories do not suppress the other guidance systems. A simple model shows that observed patterns of control could arise from a superposition of the output commands from the guidance systems, potentially approximating Bayesian inference. These results help show how an insect's relatively simple decision-making can produce navigation that is reliable and efficient and that also adapts to changing demands.

  20. Standard Review Plan Update and Development Program. Implementing Procedures Document

    Energy Technology Data Exchange (ETDEWEB)

    1992-05-01

    This implementing procedures document (IPD) was prepared for use in implementing tasks under the standard review plan update and development program (SRP-UDP). The IPD provides comprehensive guidance and detailed procedures for SRP-UDP tasks. The IPD is mandatory for contractors performing work for the SRP-UDP. It is guidance for the staff. At the completion of the SRP-UDP, the IPD will be revised (to remove the UDP aspects) and will replace NRR Office Letter No. 800 as long-term maintenance procedures.

  1. Cramér-Rao lower bound analysis for guidance systems with bearings-only measurements

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yong-an; ZHOU Di; DUAN Guang-ren

    2007-01-01

    Most currently existing investigations on the observability of passive guidance systems can only protimability analysis of closed-loop guidance systems with bearings-only measurements, is proposed. The new method provides an intuitive result for observability of the guidance system through graphical analysis. As a demonstration, a numerical example is presented, in which the degrees of observability of the guidance systems under two commonly used guidance laws are compared by using the new approach.

  2. International Conference on Harmonisation; guidance on quality of biotechnological/biological products: derivation and characterization of cell substrates used for production of biotechnological/biological products; availability. Notice. Food and Drug Administration, HHS.

    Science.gov (United States)

    1998-09-21

    The Food and Drug Administration (FDA) is publishing a guidance entitled "Q5D Quality of Biotechnological/Biological Products:Derivation and Characterization of Cell Substrates Used for Production of Biotechnological/Biological Products." The guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH).The document provides broad guidance on appropriate standards for the derivation and characterization of cell substrates used in the production of biotechnological/biological products and recommends information in these areas that should be presented in marketing applications.

  3. Review Plan Using the NWD Model Review Plan for Continuing Authorities Program Section 14, 107, 111, 204, 206, 208, 1135 and Projects Directed by Guidance to Use CAP Procedures: Sheridan, Wyoming, Section 1135 Project

    Science.gov (United States)

    2014-12-19

    directed by guidance to use CAP procedures SHERIDAN , WYOMING Section 1135 Project Omaha District MSC Approval Date: 12 January...Projects Directed by Guidance to Use CAP Procedures: Sheridan , Wyoming, Section 1135 Project 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 ii REVIEW PLAN USING THE NWD MODEL REVIEW PLAN SHERIDAN

  4. Seamless Guidance System Combining GPS, BLE Beacon, and NFC Technologies

    Directory of Open Access Journals (Sweden)

    Rung-Shiang Cheng

    2016-01-01

    Full Text Available Users rely increasingly on Location-Based Services (LBS and automated navigation/guidance systems nowadays. However, while such services are easily implemented in outdoor environments using Global Positioning System (GPS technology, a requirement still exists for accurate localization and guidance schemes in indoor settings. Accordingly, the present study proposes a system based on GPS, Bluetooth Low Energy (BLE beacons, and Near Field Communication (NFC technology. Through establishing graphic information and the design of algorithm, this study develops a guidance system for indoors and outdoors on smart phones, wishing to give user perfect smart life through this system. The proposed system is implemented on a smart phone and evaluated on a student campus environment. The experimental results confirm the ability of the proposed app to switch automatically from an outdoor mode to an indoor mode and to guide the user to requested target destination via the shortest possible route.

  5. Phase contrast image guidance for synchrotron microbeam radiotherapy

    Science.gov (United States)

    Pelliccia, Daniele; Crosbie, Jeffrey C.; Larkin, Kieran G.

    2016-08-01

    Recent image guidance developments for preclinical synchrotron microbeam radiotherapy represent a necessary step for future clinical translation of the technique. Image quality can be further improved using x-ray phase contrast, which is readily available at synchrotron facilities. We here describe a methodology for phase contrast image guidance at the Imaging and Medical Beamline at the Australian Synchrotron. Differential phase contrast is measured alongside conventional attenuation and used to improve the image quality. Post-processing based on the inverse Riesz transform is employed on the measured data to obtain noticeably sharper images. The procedure is extremely well suited for applications such as image guidance which require both visual assessment and sample alignment based on semi automatic image registration. Moreover, our approach can be combined with all other differential phase contrast imaging techniques, in all cases where a quantitative evaluation of the refractive index is not required.

  6. Application of a Fully Numerical Guidance to Mars Aerocapture

    Science.gov (United States)

    Matz, Daniel A.; Lu, Ping; Mendeck, Gavin F.; Sostaric, Ronald R.

    2017-01-01

    An advanced guidance algorithm, Fully Numerical Predictor-corrector Aerocapture Guidance (FNPAG), has been developed to perform aerocapture maneuvers in an optimal manner. It is a model-based, numerical guidance that benefits from requiring few adjustments across a variety of different hypersonic vehicle lift-to-drag ratios, ballistic co-efficients, and atmospheric entry conditions. In this paper, FNPAG is first applied to the Mars Rigid Vehicle (MRV) mid lift-to-drag ratio concept. Then the study is generalized to a design map of potential Mars aerocapture missions and vehicles, ranging from the scale and requirements of recent robotic to potential human and precursor missions. The design map results show the versatility of FNPAG and provide insight for the design of Mars aerocapture vehicles and atmospheric entry conditions to achieve desired performance.

  7. Predictive Terminal Guidance With Tuning of Prediction Horizon & Constrained Control .

    Directory of Open Access Journals (Sweden)

    S. E. Talole

    2000-07-01

    Full Text Available Continvojs time-predictive control approach is employed to formulate an output tracking nonlinear, optimal, terminal guidance ,law for re-entry vehicles. The notable features of this formulation are that the system equations are not linearised and the evaluation of the guidanceequations does not need the information of vehicle parameters, such as drag and mass. The formulation allows to impose the physical constrains on the control inputs, i..e. on the demanded lateral acceleliations through a saturation mapping and the controls are obtained using a fixed pointiteration algorithm which converges typically in a few iterations. Further, a simple method of tuning the prediction horizon needed in the guidance equations is presented. Numerical simulations show that the guidance law achieves almost zero terminal errors in all states despite large errors in initial Conditions.

  8. Interpreting guidance on prosecution for assisted dying for district nurses.

    Science.gov (United States)

    Griffith, Richard

    2014-11-01

    Following a ruling by the House of Lords in 2009, the Director of Public Prosecutions issued guidance setting out the circumstances that would be likely to lead to the prosecution of a person for encouraging or assisting suicide under the Suicide Act 1961, section 2. In that guidance, a district nurse assisting a person to commit suicide would be one of the circumstances that would lead to prosecution. The Director of Public Prosecutions recently unexpectedly amended her guidance in relation to health professionals. This article discusses the implications of the amendment and argues that it will cause confusion among district nurses and give rise to an unrealistic expectation about the role a district nurse can lawfully take in assisting a person to die.

  9. Stall Recovery Guidance Algorithms Based on Constrained Control Approaches

    Science.gov (United States)

    Stepanyan, Vahram; Krishnakumar, Kalmanje; Kaneshige, John; Acosta, Diana

    2016-01-01

    Aircraft loss-of-control, in particular approach to stall or fully developed stall, is a major factor contributing to aircraft safety risks, which emphasizes the need to develop algorithms that are capable of assisting the pilots to identify the problem and providing guidance to recover the aircraft. In this paper we present several stall recovery guidance algorithms, which are implemented in the background without interfering with flight control system and altering the pilot's actions. They are using input and state constrained control methods to generate guidance signals, which are provided to the pilot in the form of visual cues. It is the pilot's decision to follow these signals. The algorithms are validated in the pilot-in-the loop medium fidelity simulation experiment.

  10. A Predictive Explicit Guidance Scheme for Ballistic Missiles

    Directory of Open Access Journals (Sweden)

    N. Prabhakar

    2013-09-01

    Full Text Available A new approach to the design of ballistic missile guidance is presented in this paper. The proposed method uses the missile model to predict the likely impact point at every guidance cycle and apply course corrections based on the predicted impact point (PIP deviations. The algorithm also estimates the in-flight thrust variation from nominal and accordingly updates the model to reduce the uncertainty in the prediction of the impact point. The performance of the algorithm is tested through 6-DOF simulation. The simulation results show excellent performance of the proposed guidance scheme in nominal & off nominal cases.Defence Science Journal, 2013, 63(5, pp.456-461, DOI:http://dx.doi.org/10.14429/dsj.63.2575

  11. Rapid near-optimal aerospace plane trajectory generation and guidance

    Science.gov (United States)

    Corban, J. E.; Calise, A. J.; Flandro, G. A.

    1991-01-01

    Problems associated with onboard trajectory optimization, propulsion system cycle selection, and the synthesis of guidance laws are addressed for ascent to low earth orbit of an airbreathing, single-stage-to-orbit vehicle. A multicycle propulsion system is assumed that incorporates turbojet, ramjet, scramjet, and rocket engines. An energy state approximation is applied to a singularly perturbed, four-state dynamic model for flight of a point mass over a spherical nonrotating earth. An algorithm is then derived for generating both the fuel-optimal climb profile and the guidance commands required to follow that profile. In particular, analytic switching conditions are derived that, under appropriate assumptions, efficiently govern optimal transition from one propulsion cycle to another. The algorithm proves to be computationally efficient and suitable for real-time implementation. The paper concludes with the presentation of representative numerical results that illustrate the nature of the fuel-optimal climb paths and the tracking performance of the guidance algorithm.

  12. Research on Additional Loss of Guidance Optical Fiber

    Institute of Scientific and Technical Information of China (English)

    CUI De-dong; HAO Chong-yang

    2010-01-01

    The factors which cause additional losses of guidance optical fiber in wound state were analyzed. A mathematical model used to analyze the macro-bend losses in the cross region producing in the precision winding process was established.For an actual guidance optical fiber, the measured data of the fiber's additional losses under low temperature and the loss curves with radius were given in the paper. The simulation results were compared with the test data. It shows that the addi-tional losses of optical fiber caused by bending and low temperature can meet the actual requirements of the fiber optical guidance system. The established model can be used to predict the change trend of fiber losses in the winding process with a certain tensile force.

  13. Guidance on the environmental risk assessment of plant pests

    DEFF Research Database (Denmark)

    Baker, R.; Candresse, T.; Dormannsne Simon, E.

    2011-01-01

    the environmental risks of plant pests that have previously been used in pest risk assessment. The limitations identified by the review led the Panel to define the new methodology for environmental risk assessment which is described in this guidance document. The guidance is primarily addressed to the EFSA PLH...... Panel and has been conceived as an enhancement of the relevant parts of the “Guidance on a harmonised framework for pest risk assessment and the identification and evaluation of pest risk management options by EFSA”. Emphasizing the importance of assessing the consequences on both the structural...... (biodiversity) and the functional (ecosystem services) aspects of the environment, this new approach includes methods for assessing both aspects for the first time in a pest risk assessment scheme. A list of questions has been developed for the assessor to evaluate the consequences for structural biodiversity...

  14. Augmented reality guidance system for peripheral nerve blocks

    Science.gov (United States)

    Wedlake, Chris; Moore, John; Rachinsky, Maxim; Bainbridge, Daniel; Wiles, Andrew D.; Peters, Terry M.

    2010-02-01

    Peripheral nerve block treatments are ubiquitous in hospitals and pain clinics worldwide. State of the art techniques use ultrasound (US) guidance and/or electrical stimulation to verify needle tip location. However, problems such as needle-US beam alignment, poor echogenicity of block needles and US beam thickness can make it difficult for the anesthetist to know the exact needle tip location. Inaccurate therapy delivery raises obvious safety and efficacy issues. We have developed and evaluated a needle guidance system that makes use of a magnetic tracking system (MTS) to provide an augmented reality (AR) guidance platform to accurately localize the needle tip as well as its projected trajectory. Five anesthetists and five novices performed simulated nerve block deliveries in a polyvinyl alcohol phantom to compare needle guidance under US alone to US placed in our AR environment. Our phantom study demonstrated a decrease in targeting attempts, decrease in contacting of critical structures, and an increase in accuracy of 0.68 mm compared to 1.34mm RMS in US guidance alone. Currently, the MTS uses 18 and 21 gauge hypodermic needles with a 5 degree of freedom sensor located at the needle tip. These needles can only be sterilized using an ethylene oxide process. In the interest of providing clinicians with a simple and efficient guidance system, we also evaluated attaching the sensor at the needle hub as a simple clip-on device. To do this, we simultaneously performed a needle bending study to assess the reliability of a hub-based sensor.

  15. Signaling mechanisms in cortical axon growth, guidance and branching

    Directory of Open Access Journals (Sweden)

    Katherine eKalil

    2011-09-01

    Full Text Available Precise wiring of cortical circuits during development depends upon axon extension, guidance and branching to appropriate targets. Motile growth cones at axon tips navigate through the nervous system by responding to molecular cues, which modulate signaling pathways within axonal growth cones. Intracellular calcium signaling has emerged as a major transducer of guidance cues but exactly how calcium signaling pathways modify the actin and microtubule cytoskeleton to evoke growth cone behaviors and axon branching is still mysterious. Axons must often pause in their outgrowth while their branches extend into targets. Some evidence suggests a competition between growth of axons and branches but the mechanisms are poorly understood. Since it is difficult to study growing axons deep within the mammalian brain, much of what we know about signaling pathways and cytoskeletal dynamics has come from studies of axonal growth cones, in many cases from non-mammalian species, growing in tissue culture. Consequently it is not well understood how guidance cues relevant to mammalian neural development in vivo signal to the growth cone cytoskeleton during axon outgrowth and guidance. In this review we describe our recent work in dissociated cultures of developing rodent sensorimotor cortex in the context of the current literature on molecular guidance cues, calcium signaling pathways and cytoskeletal dynamics that regulate growth cone behaviors. A major challenge is to relate findings in tissue culture to mechanisms of cortical development in vivo. Toward this goal, we describe our recent work in cortical slices, which preserve the complex cellular and molecular environment of the mammalian brain but allow direct visualization of growth cone behaviors and calcium signaling. Findings from this work suggest that mechanisms regulating axon growth and guidance in dissociated culture neurons also underlie development of cortical connectivity in vivo.

  16. Student nurses’ perceptions of guidance and support in rural hospitals

    Directory of Open Access Journals (Sweden)

    Steppies R. Rikhotso

    2014-02-01

    Full Text Available Background: Clinical guidance and support of nursing students in rural hospitals is a challenge for novice nurses, who rotate amongst accredited hospitals throughout the province for clinical exposure, and fid themselves in an unfamiliar environment. Theory learned at the training college is integrated with clinical exposure at hospitals and supplemented through teaching by hospital staff. Nursing students complain about lack of support and guidance from professional nurses within the hospital, some feeling restricted in execution of their nursing tasks by professional nurses and other staff. Students perceived negative attitudes from clinical staff, a lack of clinical resources, inadequate learning opportunities and a lack of support and mentoring during their clinical exposure.Objectives: This article describes perceptions of guidance and support of nursing students by professional nurses in a rural hospital and suggests guidelines for clinical guidance and support of nursing students.Method: A qualitative, explorative, descriptive and contextual design was used. Two focus group interviews were employed to collect data from a sample drawn from level II nursing students from one training college in Limpopo Province, South Africa, on different days (n = 13; n = 10. Qualitative content analysis was used to analyse data.Results: Three themes (mutual distrust and disrespect, hospital environment, and clinical guidance and support and subthemes (student behaviour and staff behaviour emerged.Conclusion: Failure to support and guide nursing students professionally may lead to high turnover and absenteeism, resulting in students’ refusal to be allocated to a rural hospital for clinical exposure. Proposed guidelines have been formulated for clinical guidance and support of nursing students at the selected rural hospital. The college and hospital management should foster collaboration between the college tutors and professional nurses

  17. Observability analysis of feature aided terminal guidance systems

    Institute of Scientific and Technical Information of China (English)

    Shijie Fan; Hongqi Fan; Huaitie Xiao; Jianpeng Fan; Qiang Fu

    2015-01-01

    Feature aided design of estimators and guidance laws can significantly improve the interception performance of the ter-minal guidance system. The achieved enhancement can be ef-fectively assessed by observability analysis methods. This paper first analyzes and discusses the existing assessment methods in a typical endgame scenario with target orientation observations. To get over their deficiencies, a novel singular value decomposition (SVD) method is proposed. Employing both theoretical analysis and numerical simulation, the proposed method can represent the degree of state observability which is enhanced by integrating tar-get features more completely and quantitatively.

  18. A Nordic perspective on career competences and guidance

    DEFF Research Database (Denmark)

    Thomsen, Rie

    This concept note reflects an initiative within the Nordic ELPGN group, in partnership with the Nordic network for adult learning (NVL), to investigate the possibilities for collaboration between the Nordic countries in developing a number of joint documents on career competences and....../or a competence framework for career learning in the Nordic countries. The objective for this concept note is to contribute to a shared Nordic frame of understanding for career competences which can be used in the ongoing development of guidance in the Nordic countries. The intended audience is guidance...

  19. Special nuclear material information, security classification guidance. Instruction

    Energy Technology Data Exchange (ETDEWEB)

    Flickinger, A.

    1982-12-03

    The Instruction reissues DoD Instruction 5210.67, July 5, 1979, and provides security classification guidance for information concerning significant quantities of special nuclear material, other than that contained in nuclear weapons and that used in the production of energy in the reactor plant of nuclear-powered ships. Security classification guidance for these data in the latter two applications is contained in Joint DoE/DoD Nuclear Weapons Classification Guide and Joint DoE/DoD Classification Guide for the Naval Nuclear Propulsion Program.

  20. Research Circles - a method for developing guidance practices

    DEFF Research Database (Denmark)

    2012-01-01

    This video reports on our work with using research circles to improve our understanding of how to provide guidance and counseling to help young people in danger of dropping out of school. The video is based on the paper: Research Circles -- a method for developing guidance practices......, and was presented at the Conference for Social Justice, Prosperity and Sustainable Employment 2012 by assistant professor Helle Merete Nordentoft from DPU (http://edu.au.dk/). The film communicating the research paper was created by Mie Nørgaard...