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Sample records for macromolecules jai press

  1. Editorial JAI edisi Juli 2016

    Directory of Open Access Journals (Sweden)

    Harjanti Widiastuti

    2016-09-01

    Full Text Available Bismillahirrohmaanirrohim,Alhamdulillahirabbil ‘aalamiin. Puji syukir marilah senantiasa kita panjatkan kehadirat Allah Swt. yang atas rahmat dan nikmat yang dikaruniakan oleh-Nya, segala urusan kita dapat selesai dengan baik. Sholawat dan salam senantiasa kita haturkan kepada Nabi besar Muhammad Saw. yang menjadi suri tauladan ummat muslimin dan mu’minin.Dalam kesempatan ini kami menyampaikan banyak terima kasih kepada semua pihak yang berkontribusi dalam perbaikan Jurnal Akuntansi dan Investasi (JAI, khususnya dalam rangka “menyesuaikan diri” dengan standar akreditasi jurnal terbaru yang dikeluarkan oleh Dirjen Perguruan Tinggi (Dikti per 2014.  JAI Volume 17 Nomor 2 tahun 2016 ini merupakan JAI yang mengalami “revolusi mental”. Kenapa kami sebut revolusi mental, karena pada edisi ini terdapat banyak perubahan yang sangat signifikan. Perubahan besar yang kami maksud dalam diri JAI antara lain; pergantian dewan editor yang kali ini ditangani oleh mereka yang memiliki fokus mendalam terhadap dunia riset. Editorial team yang baru disusun melibatkan mereka yang sudah pernah menulis di jurnal internasional bereputasi dan jurnal nasional terakreditasi. Selain perombakan editorial team, JAI juga merombak format mitra bebestari yang dulunya banyak diampu oleh para guru besar, kini hanya diisi oleh mereka yang selama tiga tahun terakhir menulis di jurnal internasional bereputasi (terindeks Scopus meskipun saat ini belum menjabat sebagai guru besar. Mitra bebestari juga melibatkan pakar dari Negara lain, yakni: Inggris, Malaysia, Piliphina dan Australia.Dalam format terbitan, JAI merubah template artikel terbitan. JAI juga sudah membangun e-journal berbasis Open Journal System (OJS, mendaftarkan DOI ke crossref, dan sudah terindeks di google scholar. Perubahan yang signifikan ini diharapkan dapat meningkatkan mutu serta kualitas JAI sebagai terbitan berkala ilmiah, dan selanjutnya mampu menjadi bahan referensi yang memberikan sumbangsih

  2. Properties of nonvolatile and antibacterial bioboard produced from bamboo macromolecules by hot pressing

    Directory of Open Access Journals (Sweden)

    Shengbo Ge

    2018-03-01

    Full Text Available Employing the antibacterial property of industrial bamboo vinegar (IBV and the photocatalytic degradation of TiO2, bamboo macromolecules were pretreated and processed into nonvolatile and antibacterial bio board (NVABB. The NVABB was then analyzed by conducting Fourier-transform infrared spectroscopy, thermogravimetric analysis and differential thermal analysis. Results show that NVABB samples had average density of 0.96 g/cm3, which is appropriate for application. In terms of physical and mechanical properties, the best NVABB sample obtained from IBV, TiO2 and bamboo had an IBV pretreatment time of 10 min, 2% TiO2 and 1% bamboo charcoal. Fourier-transform infrared spectroscopy demonstrated that optimum conditions for hot pressing were a temperature of 170 °C, duration of 15 min and the addition of IBV and TiO2. Thermogravimetric analysis/differential thermal analysis curves suggest that the thermal degradation of NVABB was less than that of bamboo and that hot pressing obviously increased the thermal stability of HDBB samples. Analysis of the antimicrobial effect revealed that IBV pretreatment improves the antibacterial property of NVABB. Keywords: Industrial bamboo vinegar, Nonvolatile and antibacterial bio board, Bamboo macromolecules, Fourier-transform infrared spectroscopy, Thermogravimetric analysis/differential thermal analysis

  3. Medial frontal GABA is lower in older schizophrenia: a MEGA-PRESS with macromolecule suppression study.

    Science.gov (United States)

    Rowland, L M; Krause, B W; Wijtenburg, S A; McMahon, R P; Chiappelli, J; Nugent, K L; Nisonger, S J; Korenic, S A; Kochunov, P; Hong, L E

    2016-02-01

    Gamma-butyric acid (GABA) dysfunction has been implicated in the pathophysiology of schizophrenia and its cognitive deficits. Proton magnetic resonance spectroscopy (MRS) was used to test the hypothesis that older participants with schizophrenia have lower anterior cingulate GABA levels compared with older control participants. One-hundred forty-five participants completed this study. For detection of GABA, spectra were acquired from the medial frontal/anterior cingulate cortex using a macromolecule-suppressed MEGA-PRESS sequence. Patients were evaluated for psychopathology and all participants completed neuropsychological tests of working memory, processing speed and functional capacity. GABA levels were significantly lower in the older participants with schizophrenia (n=31) compared with the older control (n=37) group (P=0.003) but not between the younger control (n=40) and schizophrenia (n=29) groups (P=0.994). Age strongly predicted GABA levels in the schizophrenia group accounting for 42% of the variance, but the effect of age was less in the control group accounting for 5.7% of the variance. GABA levels were specifically related to working memory but not processing speed performance, functional capacity, or positive or negative symptom severity. This is the largest MRS study of GABA in schizophrenia and the first to examine GABA without macromolecule contamination, a potentially significant issue in previous studies. GABA levels more rapidly declined with advancing age in the schizophrenia compared with the control group. Interventions targeted at halting the decline or increasing GABA levels may improve functional outcomes and quality of life as patients with schizophrenia age.

  4. Editorial JAI edisi Januari 2017

    Directory of Open Access Journals (Sweden)

    Harjanti Widiastuti

    2016-10-01

    Full Text Available Assalamu’alaikum wr wb.Bismillahirrohmaanirrohim,Alhamdulillahirabbil ‘aalamiin. Puji syukir marilah senantiasa kita panjatkan kehadirat Allah Swt. yang atas rahmat dan nikmat yang dikaruniakan oleh-Nya, segala urusan kita dapat selesai dengan baik. Sholawat dan salam marilah senantiasa kita haturkan kepada Nabi besar Muhammad Saw. yang menjadi suri tauladan ummat muslimin dan mu’minin di dunia ini. Semoga syafaat beliau dapat kita peroleh di hari akhirat nanti.Dalam kesempatan ini kami menyampaikan banyak terima kasih kepada semua pihak yang telah terlibat dan berkontribusi dalam penerbita Jurnal Akuntansi dan Investasi (JAI Volume 18 Nomor 1, edisi Januari 2017, khususnya kepada para reviewer dan editorial board yang telah sudi menyediakan waktu untuk memberikan penilaian, kritik, saran dan rekomendasi atas semua artikel yang masuk ke JAI. Berbagai masukan tersebut diharapkan dapat meningkatkan kualitas artikel yang dipublikasikan oleh JAI.Selain itu, kami juga menghaturkan banyak terima kasih kepada para anggota editorial team, yang telah berupaya untuk mengawal proses perbaikan artikel oleh para penulis agar sesuai dengan saran dan rekomenadasi dari para reviewer dan editorial board. Kami juga menghaturkan banyak terima kasih kepada para kontributor atau penulis yang telah bersedia mengajukan naskahnya untuk dapat dimuat di JAI, serta atas kesediaan dan kesabaran dalam memrevisi dan memperbaiki artikel sesuai saran    reviewer dan editorial board yang mana seringkali masukan tersebut sangat banyak dan sangat kritis, sehingga perbaikan memerlukan waktu yang tidak sebentar. Semua hal itu kami lakukan tidak lain agar kualitas dari artikel yang diterbitkan oleh JAI dapat terjamin, sehingga dapat memberikan kontribusi yang baik dalam pengembangan ilmu akuntansi, baik secara teoritis maupun praktis.Pada JAI Volume 18 Nomor 1, edisi Januari 2017 ini termuat tulisan artikel beberapa peneliti dari berbagai Universitas terkemuka dalam hal

  5. Observatories of Sawai Jai Singh II

    Science.gov (United States)

    Johnson-Roehr, Susan N.

    Sawai Jai Singh II, Maharaja of Amber and Jaipur, constructed five observatories in the second quarter of the eighteenth century in the north Indian cities of Shahjahanabad (Delhi), Jaipur, Ujjain, Mathura, and Varanasi. Believing the accuracy of his naked-eye observations would improve with larger, more stable instruments, Jai Singh reengineered common brass instruments using stone construction methods. His applied ingenuity led to the invention of several outsize masonry instruments, the majority of which were used to determine the coordinates of celestial objects with reference to the local horizon. During Jai Singh's lifetime, the observatories were used to make observations in order to update existing ephemerides such as the Zīj-i Ulugh Begī. Jai Singh established communications with European astronomers through a number of Jesuits living and working in India. In addition to dispatching ambassadorial parties to Portugal, he invited French and Bavarian Jesuits to visit and make use of the observatories in Shahjahanabad and Jaipur. The observatories were abandoned after Jai Singh's death in 1743 CE. The Mathura observatory was disassembled completely before 1857. The instruments at the remaining observatories were restored extensively during the nineteenth and twentieth centuries.

  6. Jantar Mantar: Observatories of Jai Singh (with pop-up pages)

    Indian Academy of Sciences (India)

    BOOK REVIEW. Jantar Mantar: Observatories of Jai. Singh (with pop-up pages). Biman Nath. Jantar Mantar: Observatories of Jai Singh. By: B S Shylaja and V S S Sastry. Bilingual Edition: English and Kannada. Published by Bangalore Association for. Science Education, Price:|500. Most of us have looked at the giant ...

  7. Frontón Euskal Jai Berri Huarte-Pamplona España

    Directory of Open Access Journals (Sweden)

    Guibert Tabar, Javier

    1979-06-01

    Full Text Available The Euskal Jai Berri sports pavilion in Huarte substitutes for the old Pamplona «pelota» court, and is located a few kilometers outside the city in ample grounds providing sufficient room for the building and car park area. The vast complex design plan includes from the regulationsized court, through the grandstand and boxes for the audience, to a number of facilities and services for payers, audience and staff, such as locker rooms, payers lounge, press room and book-makers hall, administration office, manager's living quarters, players lodging, a bar on each floor, cafeteria and restaurant with kitchen and a number of rest rooms. The building was designed based on three main points, namely: natural lighting, modular structure and clear visibility from all angles. Emphasis was placed on integration of the building into the surrounding landscape in an effort to avoid the contrast between the inevitable prismatic shape of the court and the rounded contour of the hails surrounding it.

    El pabellón deportivo de Euskal Jal Berrl, en Huarte, destinado a sustituir al antiguo frontón de Pamplona, se encuentra emplazado a pocos kilómetros de esta ciudad, en unos amplios terrenos que proporcionan suficiente espacio para la edificación y para una extensa zona de aparcamientos. Su complejo y vasto programa abarca desde la concha reglamentaria y las gradas y palcos para espectadores, fiesta una variada serie de instalaciones y servicios para jugadores, público y personal, tales como: vestuarios, salas para pelotaris, corredores y prensa; oficinas administrativas; vivienda para el gerente; residencias para jugadores; bares en cada planta; cafetería y restaurante con cocina; así como los correspondientes aseos. En su diseño, fundamentado en tres puntos principales —iluminación natural, modulación estructural y perfecta visibilidad—, se tuvo especial cuidado en armonizar la construcción con el paisaje circundante, con el fin de

  8. Polyacid macromolecule primers

    Science.gov (United States)

    Sugama, Toshifumi.

    1989-12-26

    Hydrophilic polyacids are described, such as macromolecules of polyitaconic acid and polyacrylic acid, where such macromolecules have molecular weights >50,000 as primers between a polymeric top coating, such as polyurethane, and an oxidized aluminum or aluminum alloy. A near monolayer of primer is used in polymeric adhesive/oxidized aluminum adhered joint systems in 0.05% primer concentration to give superior results in standard peel tests. 2 figs.

  9. Indigenous development of integrated medical Linac system for cancer therapy - Jai Vigyan programme

    International Nuclear Information System (INIS)

    Singh, G.S.; Sehgal, Vijay

    2012-01-01

    6 MV integrated medical LINAC system was developed for cancer therapy jointly by CSIR-CSIO Chandigarh and SAMEER Mumbai under the Jai Vigyan Programme of the Government of India. Six machines were originally planned to be commissioned in six cancer hospitals in the country. Two machines, namely SIDDARTH I and SIDDARTH II, have already been developed and deployed at MGIMS, Sevagram, Wardha (Maharashtra) and at Cancer Institute (WIA), Adyar, Chennai. These machines are working satisfactorily since their installation. Four more machines namely SIDDARTH III-IV, are underway which will be commissioned in four national cancer institutes by the end of next year. This paper describes in brief the scientific principles of LINAC machines and technological challenges involved in the design and development of such a system of multi-disciplinary activities. (author)

  10. Macromolecules in Flatland

    Science.gov (United States)

    Prasad, Ashok

    This thesis is on statistical mechanics of semiflexible polymers, and diffusion and fluid mechanics in lipid membranes. In chapter two the worm-like chain model of DNA under an applied force in two dimensions is solved analytically in terms of an expansion in Mathieu functions. An analytical expression for the force-extension relation for long polymers is computed in terms of Mathieu characteristic functions. The nematic order parameter and average extension of the polymer stretched by a strong nematic field are also derived. In chapter three the force-extension relations for short semiflexible polymers or long polymers under large forces are calculated analytically using the generating functional formalism of field theory. It is shown that boundary conditions like axis-clamping affect the force extension curves. This formalism is also applied to a charged polymer under the influence of an electric field, and analytical formulae for the force-extension relation are obtained. In chapter four the results of an experiment on the collapse of actin molecule into racquet-like structures due to the depletion interaction are reported, and the strength of the attractive interaction between actin filaments is measured. In chapter five a theoretical model of polymer diffusion in supported membranes is constructed. The velocity fields of inclusions in lipid membranes are analyzed and it is found that inclusions create domains of entrained lipids of a characteristic size. The diffusion constant of a self-avoiding polymer in the membrane is calculated and it is shown that by altering the hydrodynamic length scale which sets the size of the entrained domains, the diffusive properties of the polymer changes in character from uncorrelated Rouse-like behavior to a solid disk-like behavior. The implications for the diffusion of macromolecules in plasma membranes are discussed. In chapter six the drift of a moving object in a lipid membrane is studied. The drift is a measure of the

  11. The radiation chemistry of macromolecules

    CERN Document Server

    1973-01-01

    The Radiation Chemistry of Macromolecules, Volume II is a collection of papers that discusses radiation chemistry of specific systems. Part 1 deals with radiation chemistry of substituted vinyl polymers, particularly polypropylene (PP) as its structure is intermediate between polyethylene and polyisobutylene. This part also discusses polypropylene oxide (PPOx) for it can be prepared in the atactic, isotactic, and optically active forms. One paper focuses on the fundamental chemical processes and the changes in physical properties that give rise to many different applications of polystyrene. An

  12. Diagram of state of stiff amphiphilic macromolecules

    NARCIS (Netherlands)

    Markov, Vladimir A.; Vasilevskaya, Valentina V.; Khalatur, Pavel G.; ten Brinke, Gerrit; Khokhlov, Alexei R.

    2007-01-01

    We studied coil-globule transitions in stiff-chain amphiphilic macromolecules via computer modeling and constructed phase diagrams for such molecules in terms of solvent quality and persistence length. We showed that the shape of the phase diagram essentially depends on the macromolecule degree of

  13. [Pēdējais karš. Atmiņa un traumas kominikācija] / Eva-Clarita Pettai

    Index Scriptorium Estoniae

    Pettai, Eva-Clarita, 1971-

    2012-01-01

    Arvustus: Pēdējais karš. Atmiņa un traumas kominikācija. Hrsg. von Mārtiņš Kaprāns, Vita Zelče. Latvijas Universitāte - Sociālo zinātņu fakultāte - Sociālo un politisko pētījumu institūts (Riga 2010)

  14. Rigidity of Glasses and Macromolecules

    Science.gov (United States)

    Thorpe, M. F.

    1998-03-01

    The simple yet powerful ideas of percolation theory have found their way into many different areas of research. In this talk we show how RIGIDITY PERCOLATION can be studied at a similar level of sophistication, using a powerful new program THE PEBBLE GAME (D. J. Jacobs and M. F. Thorpe, Phys. Rev. E) 53, 3682 (1996). that uses an integer algorithm. This program can analyse the rigidity of two and three dimensional networks containing more than one million bars and joints. We find the total number of floppy modes, and find the critical behavior as the network goes from floppy to rigid as more bars are added. We discuss the relevance of this work to network glasses, and how it relates to experiments that involve the mechanical properties like hardness and elasticity of covalent glassy networks like Ge_xAs_ySe_1-x-y and dicuss recent experiments that suggest that the rigidity transition may be first order (Xingwei Feng, W. J.Bresser and P. Boolchand, Phys. Rev. Lett 78), 4422 (1997).. This approach is also useful in macromolecules and proteins, where detailed information about the rigid domain structure can be obtained.

  15. Complex formation ions calcium with macromolecules pectin

    International Nuclear Information System (INIS)

    Khalikova, M.D.; Avloev, Kh.Kh.; Muhiddinov, Z.K.

    2005-01-01

    In clause the mechanism of sorption of ions of calcium by macromolecules of pectin is opened. Is shown, that the linkage of ions of calcium descends on acid bunches of pectin, and process carries cooperative character

  16. Mittal, Dr Jai Pal

    Indian Academy of Sciences (India)

    Elected: 1986 Section: Chemistry ... Specialization: Radiation Chemistry & Radiation Biology, Photochemistry ... Address: 11-B, Rohini Co-op. ... The 29th Mid-year meeting of the Academy will be held from 29–30 June 2018 in Infosys, Mysuru ...

  17. Molecular Imprinting of Macromolecules for Sensor Applications.

    Science.gov (United States)

    Saylan, Yeşeren; Yilmaz, Fatma; Özgür, Erdoğan; Derazshamshir, Ali; Yavuz, Handan; Denizli, Adil

    2017-04-19

    Molecular recognition has an important role in numerous living systems. One of the most important molecular recognition methods is molecular imprinting, which allows host compounds to recognize and detect several molecules rapidly, sensitively and selectively. Compared to natural systems, molecular imprinting methods have some important features such as low cost, robustness, high recognition ability and long term durability which allows molecularly imprinted polymers to be used in various biotechnological applications, such as chromatography, drug delivery, nanotechnology, and sensor technology. Sensors are important tools because of their ability to figure out a potentially large number of analytical difficulties in various areas with different macromolecular targets. Proteins, enzymes, nucleic acids, antibodies, viruses and cells are defined as macromolecules that have wide range of functions are very important. Thus, macromolecules detection has gained great attention in concerning the improvement in most of the studies. The applications of macromolecule imprinted sensors will have a spacious exploration according to the low cost, high specificity and stability. In this review, macromolecules for molecularly imprinted sensor applications are structured according to the definition of molecular imprinting methods, developments in macromolecular imprinting methods, macromolecular imprinted sensors, and conclusions and future perspectives. This chapter follows the latter strategies and focuses on the applications of macromolecular imprinted sensors. This allows discussion on how sensor strategy is brought to solve the macromolecules imprinting.

  18. System for determining sizes of biological macromolecules

    International Nuclear Information System (INIS)

    Nelson, R.M.; Danby, P.C.

    1987-01-01

    An electrophoresis system for determining the sizes of radiolabelled biological macromolecules is described. It comprises a cell containing an electrophoresis gel and having at least one lane, a voltage source connected across the gel for effecting the movement of macromolecules in the lane, a detector fixed relative to the moving molecules for generating electrical pulses responsive to signals emitted by the radiolabelled molecules; a pulse processor for counting the pulse rate, and a computational device for comparing the pulse rate to a predetermined value. (author)

  19. An Overview of Biological Macromolecule Crystallization

    Directory of Open Access Journals (Sweden)

    Irene Russo Krauss

    2013-05-01

    Full Text Available The elucidation of the three dimensional structure of biological macromolecules has provided an important contribution to our current understanding of many basic mechanisms involved in life processes. This enormous impact largely results from the ability of X-ray crystallography to provide accurate structural details at atomic resolution that are a prerequisite for a deeper insight on the way in which bio-macromolecules interact with each other to build up supramolecular nano-machines capable of performing specialized biological functions. With the advent of high-energy synchrotron sources and the development of sophisticated software to solve X-ray and neutron crystal structures of large molecules, the crystallization step has become even more the bottleneck of a successful structure determination. This review introduces the general aspects of protein crystallization, summarizes conventional and innovative crystallization methods and focuses on the new strategies utilized to improve the success rate of experiments and increase crystal diffraction quality.

  20. Press Start

    Science.gov (United States)

    Harteveld, Casper

    This level sets the stage for the design philosophy called “Triadic Game Design” (TGD). This design philosophy can be summarized with the following sentence: it takes two to tango, but it takes three to design a meaningful game or a game with a purpose. Before the philosophy is further explained, this level will first delve into what is meant by a meaningful game or a game with a purpose. Many terms and definitions have seen the light and in this book I will specifically orient at digital games that aim to have an effect beyond the context of the game itself. Subsequently, a historical overview is given of the usage of games with a serious purpose which starts from the moment we human beings started to walk on our feet till our contemporary society. It turns out that we have been using games for all kinds of non-entertainment purposes for already quite a long time. With this introductory material in the back of our minds, I will explain the concept of TGD by means of a puzzle. After that, the protagonist of this book, the game Levee Patroller, is introduced. Based on the development of this game, the idea of TGD, which stresses to balance three different worlds, the worlds of Reality, Meaning, and Play, came into being. Interested? Then I suggest to quickly “press start!”

  1. Controlled doping by self-assembled dendrimer-like macromolecules

    Science.gov (United States)

    Wu, Haigang; Guan, Bin; Sun, Yingri; Zhu, Yiping; Dan, Yaping

    2017-02-01

    Doping via self-assembled macromolecules might offer a solution for developing single atom electronics by precisely placing individual dopants at arbitrary location to meet the requirement for circuit design. Here we synthesize dendrimer-like polyglycerol macromolecules with each carrying one phosphorus atom in the core. The macromolecules are immobilized by the coupling reagent onto silicon surfaces that are pre-modified with a monolayer of undecylenic acid. Nuclear magnetic resonance (NMR) and X-ray photoelectron spectroscopy (XPS) are employed to characterize the synthesized macromolecules and the modified silicon surfaces, respectively. After rapid thermal annealing, the phosphorus atoms carried by the macromolecules diffuse into the silicon substrate, forming dopants at a concentration of 1017 cm-3. Low-temperature Hall effect measurements reveal that the ionization process is rather complicated. Unlike the widely reported simple ionization of phosphorus dopants, nitrogen and carbon are also involved in the electronic activities in the monolayer doped silicon.

  2. Noise reduction methods for nucleic acid and macromolecule sequencing

    Science.gov (United States)

    Schuller, Ivan K.; Di Ventra, Massimiliano; Balatsky, Alexander

    2018-05-08

    Methods, systems, and devices are disclosed for processing macromolecule sequencing data with substantial noise reduction. In one aspect, a method for reducing noise in a sequential measurement of a macromolecule comprising serial subunits includes cross-correlating multiple measured signals of a physical property of subunits of interest of the macromolecule, the multiple measured signals including the time data associated with the measurement of the signal, to remove or at least reduce signal noise that is not in the same frequency and in phase with the systematic signal contribution of the measured signals.

  3. Positron annihilation lifetime spectroscopy of macromolecules

    International Nuclear Information System (INIS)

    Simon, G.

    1996-01-01

    Positron annihilation lifetime spectroscopy (PALS) is a technique which makes use of the anti- particle of the electron, the positron (e + ), first predicted by Dirac in 1931. This talk will concentrate on the use of PALS as a technique in characterising macromolecules. PALS has been used by various groups to evaluate many properties that one associates with free volume such as physical ageing, gas permeability, the glass transition, uptake of a solvent, crystallinity, crosslinking, molecular mobility. One area of much interest has been the use of this technique in looking at miscibility of polymer blends. In miscible blends, the interactions of the different polymers may be expected to lead to a negative free volume of mixing because of the strong attraction between the different chains. This may influence the free volume properties. Conversely, if a material is partially miscible or totally immiscible, this should influence both the size and total content of free volume. This should be related to other properties such as mechanical properties and molecular mobility, such as measured by dielectric relaxation spectroscopy. Variations on this involve copolymerization of crosslinked materials or linear thermoplastics (the ultimate 'molecular' miscibility) and this will also be discussed. Multiphase systems such as water uptake in polymers can vary polymer properties by filling molecular voids, as well as disturbing chain conformations and, in the case of polar polymers, associating with the polymer chains. The effect of polymer molecular structure on free volume - particularly in rigid polymer chains such as substituted poly(phenylenes) and liquid crystalline polymers will also be presented. Indeed, the unusual packing which arises from such anisotropic molecules leads to unusual behaviours both of the homolpolymers and subsequent liquid crystal polymer - liquid crystal polymer blends

  4. Organized monolayers of biological macromolecules on Au(111) surfaces

    DEFF Research Database (Denmark)

    Zhang, Jingdong; Chi, Qijin; Nielsen, Jens Ulrik

    2002-01-01

    Single-crystal electrochemistry and scanning tunneling microscopy directly in aqueous electrolyte solution (in situ STM) are established in physical electrochemistry but new in studies of adsorption and interfacial electrochemistry of biological macromolecules. These high-resolution techniques ha...

  5. Characterization of biological macromolecules by electrophoresis and neutron activation

    International Nuclear Information System (INIS)

    Stone, S.F.; Hancock, D.; Zeisler, R.

    1987-01-01

    A procedure combining polyacrylamide gel electrophoresis (PAGE) with INAA and autoradiography was developed to study biological macromolecules and their associated trace elements. Results from the application of this method to several metalloproteins are presented. (author)

  6. A general method to study equilibrium partitioning of macromolecules

    DEFF Research Database (Denmark)

    The distribution of macromolecules between a confined microscopic solution and a macroscopic bulk solution plays an important role in understanding separation processes such as Size Exclusion Chromatography (SEC). In this study, we have developed an efficient computational algorithm for obtaining...

  7. News/Press Releases

    Data.gov (United States)

    Office of Personnel Management — A press release, news release, media release, press statement is written communication directed at members of the news media for the purpose of announcing programs...

  8. Reciprocating pellet press

    Science.gov (United States)

    Jones, Charles W.

    1981-04-07

    A machine for pressing loose powder into pellets using a series of reciprocating motions has an interchangeable punch and die as its only accurately machines parts. The machine reciprocates horizontally between powder receiving and pressing positions. It reciprocates vertically to press, strip and release a pellet.

  9. The Global University Press

    Science.gov (United States)

    Dougherty, Peter J.

    2012-01-01

    The modern world's understanding of American university press has long been shaped by university-press books. American university-press books are good international advertisements for the universities whose logos grace their spines. The growth of transnational scholarship and the expansion of digital communications networks are converging in ways…

  10. WordPress Bible

    CERN Document Server

    Brazell, Aaron

    2010-01-01

    The WordPress Bible provides a complete and thorough guide to the largest self hosted blogging tool. This guide starts by covering the basics of WordPress such as installing and the principles of blogging, marketing and social media interaction, but then quickly ramps the reader up to more intermediate to advanced level topics such as plugins, WordPress Loop, themes and templates, custom fields, caching, security and more. The WordPress Bible is the only complete resource one needs to learning WordPress from beginning to end.

  11. Development for equipment of the milk macromolecules content detection

    Science.gov (United States)

    Ding, Guochao; Li, Weimin; Shang, Tingyi; Xi, Yang; Gao, Yunli; Zhou, Zhen

    Developed an experimental device for rapid and accurate detection of milk macromolecular content. This device developed based on laser scattered through principle, the principle use of the ingredients of the scattered light and transmitted light ratio characterization of macromolecules. Peristaltic pump to achieve automatic input and output of the milk samples, designing weak signal detection amplifier circuit for detecting the ratio with ICL7650. Real-time operating system μC / OS-II is the core design of the software part of the whole system. The experimental data prove that the device can achieve a fast real-time measurement of milk macromolecules.

  12. Hot-pressed geopolymer

    DEFF Research Database (Denmark)

    Ranjbar, Navid; Mehrali, Mohammad; Maheri, Mahmoud R.

    2017-01-01

    This research explores the use of simultaneous heating and pressing techniques in order to enhance the mechanical properties of fly ash (FA) based geopolymer under relatively low temperature conditions to ensure minimum-porosity. Four effective parameters of pressing force, alkali activator...

  13. Antimicrobial resistance challenged with metal-based antimicrobial macromolecules.

    Science.gov (United States)

    Abd-El-Aziz, Alaa S; Agatemor, Christian; Etkin, Nola

    2017-02-01

    Antimicrobial resistance threatens the achievements of science and medicine, as it deactivates conventional antimicrobial therapeutics. Scientists respond to the threat by developing new antimicrobial platforms to prevent and treat infections from these resistant strains. Metal-based antimicrobial macromolecules are emerging as an alternative to conventional platforms because they combine multiple mechanisms of action into one platform due to the distinctive properties of metals. For example, metals interact with intracellular proteins and enzymes, and catalyse various intracellular processes. The macromolecular architecture offers a means to enhance antimicrobial activity since several antimicrobial moieties can be conjugated to the scaffold. Further, these macromolecules can be fabricated into antimicrobial materials for contact-killing medical implants, fabrics, and devices. As volatilization or leaching out of the antimicrobial moieties from the macromolecular scaffold is reduced, these medical implants, fabrics, and devices can retain their antimicrobial activity over an extended period. Recent advances demonstrate the potential of metal-based antimicrobial macromolecules as effective platforms that prevent and treat infections from resistant strains. In this review these advances are thoroughly discussed within the context of examples of metal-based antimicrobial macromolecules, their mechanisms of action and biocompatibility. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Reduced adipose tissue lymphatic drainage of macromolecules in obese subjects

    DEFF Research Database (Denmark)

    Arngrim, Nanna Bjørkbom; Simonsen, L; Holst, J J

    2013-01-01

    The aim of this study was to investigate subcutaneous adipose tissue lymphatic drainage (ATLD) of macromolecules in lean and obese subjects and, furthermore, to evaluate whether ATLD may change in parallel with adipose tissue blood flow. Lean and obese male subjects were studied before and after ...... online publication, 3 July 2012; doi:10.1038/ijo.2012.98....

  15. Interactions between adsorbed macromolecules : measurements on emulsions and liquid films

    NARCIS (Netherlands)

    Vliet, van T.

    1977-01-01

    The aim of this study was to gain more insight into the factors, determining the inter- and intramolecular interactions between adsorbed macromolecules. To that end several experimental and theoretical approaches were followed, using well-defined systems. It was shown that these

  16. Chaperoning Roles of Macromolecules Interacting with Proteins in Vivo

    Directory of Open Access Journals (Sweden)

    Baik L. Seong

    2011-03-01

    Full Text Available The principles obtained from studies on molecular chaperones have provided explanations for the assisted protein folding in vivo. However, the majority of proteins can fold without the assistance of the known molecular chaperones, and little attention has been paid to the potential chaperoning roles of other macromolecules. During protein biogenesis and folding, newly synthesized polypeptide chains interact with a variety of macromolecules, including ribosomes, RNAs, cytoskeleton, lipid bilayer, proteolytic system, etc. In general, the hydrophobic interactions between molecular chaperones and their substrates have been widely believed to be mainly responsible for the substrate stabilization against aggregation. Emerging evidence now indicates that other features of macromolecules such as their surface charges, probably resulting in electrostatic repulsions, and steric hindrance, could play a key role in the stabilization of their linked proteins against aggregation. Such stabilizing mechanisms are expected to give new insights into our understanding of the chaperoning functions for de novo protein folding. In this review, we will discuss the possible chaperoning roles of these macromolecules in de novo folding, based on their charge and steric features.

  17. Adsorption of charged macromolecules at a gold electrode

    NARCIS (Netherlands)

    Kleijn, J.M.; Barten, D.; Cohen Stuart, M.A.

    2004-01-01

    Using an optical reflectometer with impinging-jet system, the adsorption from aqueous solution onto gold of three charged macromolecules has been studied: the strong linear-chain polyelectrolyte polyvinyl pyridine (PVP +), the fifth-generation poly(propylene imine) dendrimer DAB-64, which has a

  18. WordPress Bible

    CERN Document Server

    Brazell, Aaron

    2011-01-01

    Get the latest word on the biggest self-hosted blogging tool on the marketWithin a week of the announcement of WordPress 3.0, it had been downloaded over a million times. Now you can get on the bandwagon of this popular open-source blogging tool with WordPress Bible, 2nd Edition. Whether you're a casual blogger or programming pro, this comprehensive guide covers the latest version of WordPress, from the basics through advanced application development. If you want to thoroughly learn WordPress, this is the book you need to succeed.Explores the principles of blogging, marketing, and social media

  19. Two layer powder pressing

    International Nuclear Information System (INIS)

    Schreiner, H.

    1979-01-01

    First, significance and advantages of sintered materials consisting of two layers are pointed out. By means of the two layer powder pressing technique metal powders are formed resulting in compacts with high accuracy of shape and mass. Attributes of basic powders, different filling methods and pressing techniques are discussed. The described technique is supposed to find further applications in the field of two layer compacts in the near future

  20. Implications of molecular heterogeneity for the cooperativity of biological macromolecules.

    Science.gov (United States)

    Solomatin, Sergey V; Greenfeld, Max; Herschlag, Daniel

    2011-06-01

    Cooperativity, a universal property of biological macromolecules, is typically characterized by a Hill slope, which can provide fundamental information about binding sites and interactions. We demonstrate, through simulations and single-molecule FRET (smFRET) experiments, that molecular heterogeneity lowers bulk cooperativity from the intrinsic value for the individual molecules. As heterogeneity is common in smFRET experiments, appreciation of its influence on fundamental measures of cooperativity is critical for deriving accurate molecular models.

  1. A structural self-regulation of functioning macromolecules

    International Nuclear Information System (INIS)

    Khristoforov, L.N.

    1998-01-01

    An approach to describing the functional structural changes of macromolecules processing the flows of low-mass agents is formulated. The latter appear as a source of a discrete noise whose defining parameters depend on structural variables. We derive a forward evolution equation and then, by adiabatic elimination, effective Fokker-Planck's equation for the structural modes. Within the dichotomous case, we discuss noise-induced nonequilibrium phase transitions reflecting the regulatory role of the structural subsystem

  2. ALUMINUM BOX BUNDLING PRESS

    Directory of Open Access Journals (Sweden)

    Iosif DUMITRESCU

    2015-05-01

    Full Text Available In municipal solid waste, aluminum is the main nonferrous metal, approximately 80- 85% of the total nonferrous metals. The income per ton gained from aluminum recuperation is 20 times higher than from glass, steel boxes or paper recuperation. The object of this paper is the design of a 300 kN press for aluminum box bundling.

  3. DSS / Press Room

    Science.gov (United States)

    Defense Security Service, U.S. Department of Defense Site Map | A-Z Index | Facebook | Twitter Locations Press Room Organizational Structure Careers at DSS Doing Business with DSS Frequently Asked Classification System (NCCS) National Industrial Security System (NISS) ODAA Business Management System (OBMS

  4. OAS :: Press Releases

    Science.gov (United States)

    subscriptions Videos Photos Live Webcast Social Media Facebook @oasofficial Facebook Twitter @oas_official Social Media Facebook Twitter Newsletters Press and Communications Department Contact us at: +1 (202) 370 Rights Actions against Corruption C Children Civil Registry Civil Society Contact Us Culture Cyber

  5. bbPress complete

    CERN Document Server

    Wynne, Rhys

    2013-01-01

    A concise guide, written in an easy-to-follow format.This book is aimed at ambitious website or blog owners looking to add a forum to their site quickly and easily. Basic experience in WordPress and with managing a website is expected. Knowledge of HTML and PHP will be a bonus, though it isn't necessary.

  6. Myths About Press Freedom

    Directory of Open Access Journals (Sweden)

    Kaarle Nordenstreng

    2007-06-01

    Full Text Available This article intends to rectify three popular beliefs related to press freedom: (1 that the idea of a free marketplace of ideas with a self-righting truth belongs to original liberalism, (2 that UNESCO’s primary mission is to promote freedom of information, and (3 that the Universal Declaration of Human Rights provides legal safeguards for the media. These beliefs are shown, on the basis of the legacy of liberalism and documents of the international community, to be misleading myths. Instead of accurate readings of the idea of freedom, they serve as ideological positions which are harmful to democracy. The Millennium Declaration provides further proof that the international community has a much more balanced view of freedom of information than that typically held by media professionals. Therefore it is important to liberate the concept of press freedom from its ideological baggage.

  7. Basal-body-associated macromolecules: a continuing debate.

    Science.gov (United States)

    Pierre Mignot, J; Brugerolle, G; Didier, P; Bornens, M

    1993-07-01

    Controversy over the possibility that centrioles/basal bodies contain nucleic acids has overshadowed results demonstrating other macromolecules in the lumen of these organelles. Glycogen particles, which are known to be present within the lumen of the centriole/basal body of sperm cells, have now been found in basal bodies of protists belonging to three different groups. Here, we extend the debate on a role for RNA in basal body/centriole function and speculate on the origin and the function of centriolar glycogen.

  8. Tunable Tensor Voting Improves Grouping of Membrane-Bound Macromolecules

    Energy Technology Data Exchange (ETDEWEB)

    Loss, Leandro A.; Bebis, George; Parvin, Bahram

    2009-04-15

    Membrane-bound macromolecules are responsible for structural support and mediation of cell-cell adhesion in tissues. Quantitative analysis of these macromolecules provides morphological indices for damage or loss of tissue, for example as a result of exogenous stimuli. From an optical point of view, a membrane signal may have nonuniform intensity around the cell boundary, be punctate or diffused, and may even be perceptual at certain locations along the boundary. In this paper, a method for the detection and grouping of punctate, diffuse curvilinear signals is proposed. Our work builds upon the tensor voting and the iterative voting frameworks to propose an efficient method to detect and refine perceptually interesting curvilinear structures in images. The novelty of our method lies on the idea of iteratively tuning the tensor voting fields, which allows the concentration of the votes only over areas of interest. We validate the utility of our system with synthetic and annotated real data. The effectiveness of the tunable tensor voting is demonstrated on complex phenotypic signals that are representative of membrane-bound macromolecular structures.

  9. Physiologically-based PK/PD modelling of therapeutic macromolecules.

    Science.gov (United States)

    Thygesen, Peter; Macheras, Panos; Van Peer, Achiel

    2009-12-01

    Therapeutic proteins are a diverse class of drugs consisting of naturally occurring or modified proteins, and due to their size and physico-chemical properties, they can pose challenges for the pharmacokinetic and pharmacodynamic studies. Physiologically-based pharmacokinetics (PBPK) modelling has been effective for early in silico prediction of pharmacokinetic properties of new drugs. The aim of the present workshop was to discuss the feasibility of PBPK modelling of macromolecules. The classical PBPK approach was discussed with a presentation of the successful example of PBPK modelling of cyclosporine A. PBPK model was performed with transport of the cyclosporine across cell membranes, affinity to plasma proteins and active membrane transporters included to describe drug transport between physiological compartments. For macromolecules, complex PBPK modelling or permeability-limited and/or target-mediated distribution was discussed. It was generally agreed that PBPK modelling was feasible and desirable. The role of the lymphatic system should be considered when absorption after extravascular administration is modelled. Target-mediated drug disposition was regarded as an important feature for generation of PK models. Complex PK-models may not be necessary when a limited number of organs are affected. More mechanistic PK/PD models will be relevant when adverse events/toxicity are included in the PK/PD modelling.

  10. JAIL: a structure-based interface library for macromolecules.

    Science.gov (United States)

    Günther, Stefan; von Eichborn, Joachim; May, Patrick; Preissner, Robert

    2009-01-01

    The increasing number of solved macromolecules provides a solid number of 3D interfaces, if all types of molecular contacts are being considered. JAIL annotates three different kinds of macromolecular interfaces, those between interacting protein domains, interfaces of different protein chains and interfaces between proteins and nucleic acids. This results in a total number of about 184,000 database entries. All the interfaces can easily be identified by a detailed search form or by a hierarchical tree that describes the protein domain architectures classified by the SCOP database. Visual inspection of the interfaces is possible via an interactive protein viewer. Furthermore, large scale analyses are supported by an implemented sequential and by a structural clustering. Similar interfaces as well as non-redundant interfaces can be easily picked out. Additionally, the sequential conservation of binding sites was also included in the database and is retrievable via Jmol. A comprehensive download section allows the composition of representative data sets with user defined parameters. The huge data set in combination with various search options allow a comprehensive view on all interfaces between macromolecules included in the Protein Data Bank (PDB). The download of the data sets supports numerous further investigations in macromolecular recognition. JAIL is publicly available at http://bioinformatics.charite.de/jail.

  11. Progress in hot pressing

    International Nuclear Information System (INIS)

    Brodhag, C.; Thevenot, F.

    1988-01-01

    An experimental technique is described to study hot pressing of ceramics under conditions of controlled temperature and pressure during both the heating and final sintering stages. This method gives a better control of the final microstructure of the material. Transformation mechanisms can be studied during initial heating stage (impurity degasing, reaction, phase transformation, mechanical behavior of intergranular phase...) using computer control and graphical data representations. Some examples will be given for different systems studied in our laboratory: B (α, β, amorphous), B 12 O 2 (reaction of B + B 2 O 3 ), Si 3 N 4 ( + additives), TiN, Al 2 O 3 + AlON,ZrC

  12. ISS Expedition 08 Press Kit

    Data.gov (United States)

    National Aeronautics and Space Administration — Press kit for ISS mission Expedition 08 from 10/2003-04/2004. Press kits contain information about each mission overview, crew, mission timeline, benefits, and media...

  13. WordPress multisite administration

    CERN Document Server

    Longren, Tyler

    2013-01-01

    This is a simple, concise guide with a step-by-step approach, packed with screenshots and examples to set up and manage a network blog using WordPress.WordPress Multisite Administration is ideal for anyone wanting to familiarize themselves with WordPress Multisite. You'll need to know the basics about WordPress, and having at least a broad understanding of HTML, CSS, and PHP will help, but isn't required.

  14. Four Theories of the Press.

    Science.gov (United States)

    Siebert, Fred S.; And Others

    A systematic understanding of the press requires an understanding of the social and political structures within which the press operates. This book discusses four theories that have determined the kind of press the Western world has had: authoritarian, libertarian, socially responsible, and Soviet communist. Each chapter discusses press…

  15. Long charged macromolecule in an entropic trap with rough surfaces.

    Science.gov (United States)

    Mamasakhlisov, Yevgeni Sh; Hayryan, Shura; Hu, Chin-Kun

    2012-11-01

    The kinetics of the flux of a charged macromolecular solution through an environment of changing geometry with wide and constricted regions is investigated analytically. A model device consisting of alternating deep and shallow slits known as an "entropic trap" is used to represent the environment. The flux is supported by the external electrostatic field. The "wormlike chain" model is used for the macromolecule (dsDNA in the present study). The chain entropy in both the deep and the shallow slits, the work by the electric field, and the energy of the elastic bending of the chain are taken into account accurately. Based on the calculated free energy, the kinetics and the scaling behavior of the chain escaping from the entropic trap are studied. We find that the escape process occurs in two kinetic stages with different time scales and discuss the possible influence of the surface roughness. The scope of the accuracy of the proposed model is discussed.

  16. Macromolecule exchange in Cuscuta-host plant interactions.

    Science.gov (United States)

    Kim, Gunjune; Westwood, James H

    2015-08-01

    Cuscuta species (dodders) are parasitic plants that are able to grow on many different host plants and can be destructive to crops. The connections between Cuscuta and its hosts allow movement of not only water and small nutrients, but also macromolecules including mRNA, proteins and viruses. Recent studies show that RNAs move bidirectionally between hosts and parasites and involve a large number of different genes. Although the function of mobile mRNAs has not been demonstrated in this system, small RNAs are also transmitted and a silencing construct expressed in hosts is able to affect expression of the target gene in the parasite. High throughput sequencing of host-parasite associations has the potential to greatly accelerate understanding of this remarkable interaction. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Which Freedom of the Press?

    DEFF Research Database (Denmark)

    Rytter, Jens Elo

    2010-01-01

    The article surveys the historical and current meaning of "Freedom of the Press" in constitutional and human rights law. Two different conceptions exist, the narrow one defining freedom of the press as the freedom of every one to publish without prior restraint, the broader one defining it as a...... privileged freedom of the organised press to gather and report on information of public interest. These two conceptions have very different answers to the question of whether the press should enjoy some privilege to be exempt from ordinary legislation when such legislation restricts the access of the press to inform...

  18. WordPress for dummies

    CERN Document Server

    Sabin-Wilson, Lisa

    2014-01-01

    The bestselling WordPress guide, fully updated to cover the 2013 enhancements WordPress has millions of users, and this popular guide has sold more than 105,000 copies in its previous editions. With the newest releases of WordPress, author and WordPress expert Lisa Sabin-Wilson has completely updated the book to help you use and understand all the latest features. You'll learn about both the hosted WordPress.com version and the more flexible WordPress.org, which requires third-party hosting. Whether you're switching to WordPress from another blogging platform or just beginning to blog, you'll

  19. Highly Resolved Sub-Terahertz Vibrational Spectroscopy of Biological Macromolecules and Bacteria Cells

    Science.gov (United States)

    2016-07-01

    HIGHLY RESOLVED SUB-TERAHERTZ VIBRATIONAL SPECTROSCOPY OF BIOLOGICAL MACROMOLECULES AND BACTERIA CELLS ECBC...SUBTITLE Highly Resolved Sub-Terahertz Vibrational Spectroscopy of Biological Macromolecules and Bacteria Cells 5a. CONTRACT NUMBER W911SR-14-P...22 4.3 Bacteria THz Study

  20. Macromolecule biosynthesis assay and fluorescence spectroscopy methods to explore antimicrobial peptide mode(s) of action

    DEFF Research Database (Denmark)

    Jana, Bimal; Baker, Kristin Renee; Guardabassi, Luca

    2017-01-01

    the biosynthesis rate of macromolecules (e.g., DNA, RNA, protein, and cell wall) and the cytoplasmic membrane proton motive force (PMF) energy can help to unravel the diverse modes of action of AMPs. Here, we present an overview of macromolecule biosynthesis rate measurement and fluorescence spectroscopy methods...

  1. The flavonoid herbacetin diglucoside as a constituent of the lignan macromolecule from flaxseed hulls

    NARCIS (Netherlands)

    Struijs, K.; Vincken, J.P.; Verhoef, R.P.; Oostveen, van W.H.M.; Voragen, A.G.J.; Gruppen, H.

    2007-01-01

    Lignans in flaxseed are known to be part of a macromolecule in which they are connected through the linker-molecule hydroxy-methyl-glutaric acid (HMGA). In this study, the lignan macromolecule was extracted from flaxseed hulls and degraded to its monomeric constituents by complete saponification.

  2. WordPress For Dummies

    CERN Document Server

    Sabin-Wilson, Lisa

    2011-01-01

    The bestselling guide to WordPress, fully updated to help you get your blog going! Millions of bloggers rely on WordPress, the popular, free blogging platform. This guide covers all the features and improvements in the most up-to-date version of WordPress. Whether you are switching to WordPress from another blogging platform or just starting your first blog, you'll find the advice in this friendly guide gets you up to speed on both the free-hosted WordPress.com version and WordPress.org, which requires the purchase of web hosting services, and figure out which version is best for you. You'll b

  3. WordPress Top Plugins

    CERN Document Server

    Corbin, Brandon

    2010-01-01

    Time flies when you're having fun. This is the right way to describe this WordPress Top Plugins book by Brandon Corbin. With real world examples and by showing you the perks of having these plugins installed on your websites, the author is all set to captivate your interest from start to end. Regardless of whether this is your first time working with WordPress, or you're a seasoned WordPress coding ninja, WordPress Top Plugins will walk you through finding and installing the best plugins for generating and sharing content, building communities and reader base, and generating real advertising r

  4. Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications

    Directory of Open Access Journals (Sweden)

    Madeline Small

    2018-05-01

    Full Text Available Advances in nanotechnology and nanomaterials have enabled the development of functional biomaterials with surface properties that reduce the rate of the device rejection in injectable and implantable biomaterials. In addition, the surface of biomaterials can be functionalized with macromolecules for stimuli-responsive purposes to improve the efficacy and effectiveness in drug release applications. Furthermore, macromolecule-grafted surfaces exhibit a hierarchical nanostructure that mimics nanotextured surfaces for the promotion of cellular responses in tissue engineering. Owing to these unique properties, this review focuses on the grafting of macromolecules on the surfaces of various biomaterials (e.g., films, fibers, hydrogels, and etc. to create nanostructure-enabled and macromolecule-grafted surfaces for biomedical applications, such as thrombosis prevention and wound healing. The macromolecule-modified surfaces can be treated as a functional device that either passively inhibits adverse effects from injectable and implantable devices or actively delivers biological agents that are locally based on proper stimulation. In this review, several methods are discussed to enable the surface of biomaterials to be used for further grafting of macromolecules. In addition, we review surface-modified films (coatings and fibers with respect to several biomedical applications. Our review provides a scientific update on the current achievements and future trends of nanostructure-enabled and macromolecule-grafted surfaces in biomedical applications.

  5. Improved data visualization techniques for analyzing macromolecule structural changes.

    Science.gov (United States)

    Kim, Jae Hyun; Iyer, Vidyashankara; Joshi, Sangeeta B; Volkin, David B; Middaugh, C Russell

    2012-10-01

    The empirical phase diagram (EPD) is a colored representation of overall structural integrity and conformational stability of macromolecules in response to various environmental perturbations. Numerous proteins and macromolecular complexes have been analyzed by EPDs to summarize results from large data sets from multiple biophysical techniques. The current EPD method suffers from a number of deficiencies including lack of a meaningful relationship between color and actual molecular features, difficulties in identifying contributions from individual techniques, and a limited ability to be interpreted by color-blind individuals. In this work, three improved data visualization approaches are proposed as techniques complementary to the EPD. The secondary, tertiary, and quaternary structural changes of multiple proteins as a function of environmental stress were first measured using circular dichroism, intrinsic fluorescence spectroscopy, and static light scattering, respectively. Data sets were then visualized as (1) RGB colors using three-index EPDs, (2) equiangular polygons using radar charts, and (3) human facial features using Chernoff face diagrams. Data as a function of temperature and pH for bovine serum albumin, aldolase, and chymotrypsin as well as candidate protein vaccine antigens including a serine threonine kinase protein (SP1732) and surface antigen A (SP1650) from S. pneumoniae and hemagglutinin from an H1N1 influenza virus are used to illustrate the advantages and disadvantages of each type of data visualization technique. Copyright © 2012 The Protein Society.

  6. Molecular simulation of methane adsorption characteristics on coal macromolecule

    Science.gov (United States)

    Yang, Zhiyuan; He, Xiaoxiao; Meng, Zhuoyue; Xue, Wenying

    2018-02-01

    In this paper, the molecular model of anthracite named Wender2 was selected to study the adsorption behaviour of single component CH4 and the competitive adsorption of CH4/CO2, CH4/H2O and CH4/N2. The molecular model of anthracite was established by molecular simulation software (Materials Studio 8.0), and Grand Canonical Monte Carlo (GCMC) simulations were carried out to investigate the single and binary component adsorption. The effects of pressure and temperature on the adsorption position, adsorption energy and adsorption capacity were mainly discussed. The results show that for the single component adsorption, the adsorption capacity of CH4 increases rapidly with the pressure ascending, and then tends to be stable after the first step. The low temperature is favourable for the adsorption of CH4, and the high temperature promotes desorption quantity of CH4 from the coal. Adsorbent molecules are preferentially adsorbed on the edge of coal macromolecules. The order of adsorption capacity of CH4/CO2, CH4/H2O and CH4/N2 in the binary component is H2O>CO2>CH4>N2. The change of pressure has little effect on the adsorption capacity of the adsorbent in the competitive adsorption, but it has a great influence on the adsorption capacity of the adsorbent, and there is a positive correlation between them.

  7. Maximizing Macromolecule Crystal Size for Neutron Diffraction Experiments

    Science.gov (United States)

    Judge, R. A.; Kephart, R.; Leardi, R.; Myles, D. A.; Snell, E. H.; vanderWoerd, M.; Curreri, Peter A. (Technical Monitor)

    2002-01-01

    A challenge in neutron diffraction experiments is growing large (greater than 1 cu mm) macromolecule crystals. In taking up this challenge we have used statistical experiment design techniques to quickly identify crystallization conditions under which the largest crystals grow. These techniques provide the maximum information for minimal experimental effort, allowing optimal screening of crystallization variables in a simple experimental matrix, using the minimum amount of sample. Analysis of the results quickly tells the investigator what conditions are the most important for the crystallization. These can then be used to maximize the crystallization results in terms of reducing crystal numbers and providing large crystals of suitable habit. We have used these techniques to grow large crystals of Glucose isomerase. Glucose isomerase is an industrial enzyme used extensively in the food industry for the conversion of glucose to fructose. The aim of this study is the elucidation of the enzymatic mechanism at the molecular level. The accurate determination of hydrogen positions, which is critical for this, is a requirement that neutron diffraction is uniquely suited for. Preliminary neutron diffraction experiments with these crystals conducted at the Institute Laue-Langevin (Grenoble, France) reveal diffraction to beyond 2.5 angstrom. Macromolecular crystal growth is a process involving many parameters, and statistical experimental design is naturally suited to this field. These techniques are sample independent and provide an experimental strategy to maximize crystal volume and habit for neutron diffraction studies.

  8. N-hydroxysuccinimide-hippuran ester: application for radiolabeling of macromolecules

    International Nuclear Information System (INIS)

    Chervu, L.R.; Chun, S.B.; Bhargava, K.K.

    1987-01-01

    A method for synthesis of N-hydroxysuccinimide ester of radioactive orthoiodohippurric acid (OIH-OSU) is developed in order to label macromolecules including antibodies. The OIH-OSU is prepared in 87% yield by reacting molar equivalents of o-iodohippuric acid, N:N-di-succinimidyl carbonate and pyridine in DMF overnight. The active labeled ester is obtained using high specific activity OIH in a similar synthetic protocol. Conjugation of OIH-OSU to human serum albumin is effected by incubating the reactants for half an hour at room temperature followed by purification of the labeled protein on a Sephadex G-100 column with activity yield of 44.3%. Organ distribution for the labeled albumin preparation and the commercial iodinated human serum albumin (RISA) in mice and rats is similar. As expected urinary excretion of radioactivity for the labeled preparation is greater than that of RISA reflecting the rapid urinary clearance of the OIH moiety released into the bloodstream. Hippuran labeling method offers a mild and rapid protocol for radioiodine labeling of proteins and antibodies for application in diagnostic nuclear medicine procedures

  9. Unsolved problems of crystallization and melting of flexible macromolecules

    International Nuclear Information System (INIS)

    Wunderlich, B.

    1992-01-01

    The thermodynamics, kinetics, and computer simulations of crystallization and melting is discussed. The thermodynamics is shown to be well understood, although for many specific crystals not enough details for full description are available. Experiments on the crystallization kinetics of poly(ethylene) and poly(oxyethylene) in the presence of crystal nuclei as a function of molecular mass revealed that with increasing mass, the crystallization behavior deviates increasingly from that of small, rigid molecules. Instead of showing a continuously changing, linear crystallization rate with temperature through the equilibrium melting temperature, T m 0 , these flexible macromolecules show a region of practically zero crystallization rate between T m 0 and about (T m 0 - 15) K, creating a temperature region of metastability in the melt that cannot be broken by nucleation with pregrown crystals. Molecular Nucleation was proposed as a cooperative process to be of overriding importance for the description of polymer crystallization, and to be at the center of segregation of molecules of lower molecular mass by growing crystal fronts. Initial efforts to model sufficiently large crystals using Monte Carlo and molecular dynamics methods are presented. Some of the short-time intermediates in the melting, crystallization, and annealing processes seem to have little similarity to commonly assumed models of crystallization and melting and are presented as discussion topics

  10. Interaction between manufactured gold nanoparticles and naturally occurring organic macromolecules

    International Nuclear Information System (INIS)

    Diegoli, Sara; Manciulea, Adriana L.; Begum, Shakiela; Jones, Ian P.; Lead, Jamie R.; Preece, Jon A.

    2008-01-01

    The increasing exploitation of nanomaterials into many consumer and other products is raising concerns as these nanomaterials are likely to be released into the environment. Due to our lack of knowledge about the environmental chemistry, transport and ecotoxicology of nanomaterials, it is of paramount importance to study how natural aquatic colloids can interact with manufactured gold nanoparticles as these interactions will determine their environmental fate and behaviour. In this context, our work aims to quantify the effect of naturally occurring riverine macromolecules - International Humic Substances Society (IHSS) Suwannee River Humic Acid Standard (SRHA) - on citrate- and acrylate-stabilized gold nanoparticles. The influence of SRHA on the stability of the gold colloids was studied as a function of pH by UV-visible absorption spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM). At high ionic strengths (0.1 M), extensive and rapid aggregation occurred, while more subtle effects were observed at lower ionic strength values. Evidence was found that SRHA enhances particle stability at extreme pH values (ionic strength < 0.01 M) by substituting and/or over-coating the original stabilizer on the gold nanoparticle surface, thus affecting surface charge and chemistry. These findings have important implications for the fate and behaviour of nanoparticles in the environment and their ecotoxicity

  11. Indre spenninger og ytre press

    DEFF Research Database (Denmark)

    Ibsen, Bjarne

    2011-01-01

    Anmeldelse af bogen 'Norsk idrett. Indre spenninger og ytre press' redigeret af Dag Vidar Hanstad, Gunnar Breivik, Mari Kristin Sisjord og Hans B. Skaset og udgivet af forlaet akilles.......Anmeldelse af bogen 'Norsk idrett. Indre spenninger og ytre press' redigeret af Dag Vidar Hanstad, Gunnar Breivik, Mari Kristin Sisjord og Hans B. Skaset og udgivet af forlaet akilles....

  12. BuddyPress theme development

    CERN Document Server

    Lister, Tammie

    2013-01-01

    This book is a hands-on tutorial guide to using BuddyPress.This book is great for designers and developers who are looking to learn how to develop BuddyPress themes. It's assumed that the reader has some understanding of Wordpress and is familiar with CSS and HTML.

  13. Head First WordPress

    CERN Document Server

    Siarto, Jeff

    2010-01-01

    Whether you're promoting your business or writing about your travel adventures, Head First WordPress will teach you not only how to make your blog look unique and attention-grabbing, but also how to dig into the more complex features of WordPress 3.0 to make your website work well, too. You'll learn how to move beyond the standard WordPress look and feel by customizing your blog with your own URL, templates, plugin functionality, and more. As you learn, you'll be working with real WordPress files: The book's website provides pre-fab WordPress themes to download and work with as you follow al

  14. Comment j'ai pourri le web

    Directory of Open Access Journals (Sweden)

    Loys Bonod

    2012-04-01

    Full Text Available Ce texte décrit l’expérience pédagogique faite par un professeur de Lycée, à Paris, qui pour prouver la dépendance de la pensée vis-à-vis du numérique, a piégé ses élèves. Il a publié sur différents sites (Wikipédia, entre autres des commentaires – vrais et faux – sur un poème relativement rare, puis il a interrogé ses étudiants. Le but était de démontrer aux élèves qu’ils ne sont pas assez mûrs pour analyser sainement tous les contenus internet car leur curiosité, sélection  et jugement restent trop restreints.

  15. In vivo skin penetration of macromolecules in irritant contact dermatitis.

    Science.gov (United States)

    Abdel-Mottaleb, Mona M A; Lamprecht, Alf

    2016-12-30

    Recently, a selective preferential accumulation of polymeric nanoparticles (in the size range around 100nm) has been observed in the follicular system of dermatitis skin. The present investigation aimed at clearly investigating the effect of irritant contact dermatitis on the barrier permeability for colloidal systems below this size range, namely quantum dots and hydrophilic macromolecules. Irritant dermatitis was induced in mice and the penetrability of quantum dots (5nm) and hydrophilic dextran molecules has been tracked in both healthy and inflamed skin using confocal laser scanning microscopy. The selective accumulation of the quantum dots was clearly observed in inflamed skin while hydrophilic dextran behaved similarly in both healthy and inflamed skin. The therapeutic potential for the transdermal delivery of peptide drugs through inflamed skin has been also tested in rats. Results revealed that the transdermal permeation of insulin and calcitonin was not significantly enhanced in dermatitis compared to healthy skin. On the other side, permeation through stripped skin was significantly higher. However, the effect was limited and shorter compared to the SC injection where t min was 0.5h and 2h with a 70% and 46% reduction in blood glucose levels for the stripped skin and the SC injection respectively. Similarly, t min was 4h and 8h with area under the curve of 161±65% and 350±97% for the stripped skin and the SC injection respectively. In conclusion, the changes in skin permeability accompanied with skin inflammation did not affect its permeability to peptide drugs. Our findings also underline that experiments with the tape stripped skin model as a surrogate for inflamed skin can risk misleading conclusions due to significant difference of skin permeability between the tape stripped skin and inflamed skin. Copyright © 2016 Elsevier B.V. All rights reserved.

  16. Sub-terahertz resonance spectroscopy of biological macromolecules and cells

    Science.gov (United States)

    Globus, Tatiana; Moyer, Aaron; Gelmont, Boris; Khromova, Tatyana; Sizov, Igor; Ferrance, Jerome

    2013-05-01

    Recently we introduced a Sub-THz spectroscopic system for characterizing vibrational resonance features from biological materials. This new, continuous-wave, frequency-domain spectroscopic sensor operates at room temperature between 315 and 480 GHz with spectral resolution of at least 1 GHz and utilizes the source and detector components from Virginia Diode, Inc. In this work we present experimental results and interpretation of spectroscopic signatures from bacterial cells and their biological macromolecule structural components. Transmission and absorption spectra of the bacterial protein thioredoxin, DNA and lyophilized cells of Escherichia coli (E. coli), as well as spores of Bacillus subtillis and B. atrophaeus have been characterized. Experimental results for biomolecules are compared with absorption spectra calculated using molecular dynamics simulation, and confirm the underlying physics for resonance spectroscopy based on interactions between THz radiation and vibrational modes or groups of modes of atomic motions. Such interactions result in multiple intense and narrow specific resonances in transmission/absorption spectra from nano-gram samples with spectral line widths as small as 3 GHz. The results of this study indicate diverse relaxation dynamic mechanisms relevant to sub-THz vibrational spectroscopy, including long-lasting processes. We demonstrate that high sensitivity in resolved specific absorption fingerprints provides conditions for reliable detection, identification and discrimination capability, to the level of strains of the same bacteria, and for monitoring interactions between biomaterials and reagents in near real-time. Additionally, it creates the basis for the development of new types of advanced biological sensors through integrating the developed system with a microfluidic platform for biomaterial samples.

  17. Macromolecule simulation and CH4 adsorption mechanism of coal vitrinite

    Science.gov (United States)

    Yu, Song; Yan-ming, Zhu; Wu, Li

    2017-02-01

    The microscopic mechanism of interactions between CH4 and coal macromolecules is of significant practical and theoretical importance in CBM development and methane storage. Under periodic boundary conditions, the optimal energy configuration of coal vitrinite, which has a higher torsion degree and tighter arrangement, can be determined by the calculation of molecular mechanics (MM) and molecular dynamics (MD), and annealing kinetics simulation based on ultimate analysis, 13C NMR, FT IR and HRTEM. Macromolecular stabilization is primarily due to the van der Waals energy and covalent bond energy, mainly consisting of bond torsion energy and bond angle energy. Using the optimal configuration as the adsorbent, GCMC simulation of vitrinite adsorption of CH4 is conducted. A saturated state is reached after absorbing 17 CH4s per coal vitrinite molecule. CH4 is preferentially adsorbed on the edge, and inclined to gathering around the branched chains of the inner vitrinite sites. Finally, the adsorption parameters are calculated through first principle DFT. The adsorbability order is as follows: aromatic structure> heteroatom rings > oxygen functional groups. The adsorption energy order is as follows: Top graphene. However, the energy of the most preferential location is much lower than that of graphite/graphene. CH4 is more easily absorbed on the surface of vitrinite. Adsorbability varies considerably at different adsorption locations and sites on the surface of vitrinite. Crystal parameter of vitrinite is a = b = c = 15.8 Å and majority of its micropores are blow 15.8 Å, indicating that the vitrinite have the optimum adsorption aperture. It can explain its higher observed adsorption capacities for CH4 compared with graphite/graphene.

  18. Smashing WordPress Themes Making WordPress Beautiful

    CERN Document Server

    Hedengren, Thord Daniel

    2011-01-01

    The ultimate guide to WordPress Themes - one of the hottest topics on the web today WordPress is so much more than a blogging platform, and Smashing WordPress Themes teaches readers how to make it look any way they like - from a corporate site, to a photography gallery and moreWordPress is one of the hottest tools on the web today and is used by sites including The New York Times, Rolling Stone, flickr, CNN, NASA and of course Smashing MagazineBeautiful full colour throughout - web designers expect nothing lessSmashing Magazine will fully support this book by by promoting it through their webs

  19. High throughput screening of ligand binding to macromolecules using high resolution powder diffraction

    Science.gov (United States)

    Von Dreele, Robert B.; D'Amico, Kevin

    2006-10-31

    A process is provided for the high throughput screening of binding of ligands to macromolecules using high resolution powder diffraction data including producing a first sample slurry of a selected polycrystalline macromolecule material and a solvent, producing a second sample slurry of a selected polycrystalline macromolecule material, one or more ligands and the solvent, obtaining a high resolution powder diffraction pattern on each of said first sample slurry and the second sample slurry, and, comparing the high resolution powder diffraction pattern of the first sample slurry and the high resolution powder diffraction pattern of the second sample slurry whereby a difference in the high resolution powder diffraction patterns of the first sample slurry and the second sample slurry provides a positive indication for the formation of a complex between the selected polycrystalline macromolecule material and at least one of the one or more ligands.

  20. Modelisation of the concentration of macromolecules moving in a Newtonian fluid

    International Nuclear Information System (INIS)

    Hijazi, A.; Zoaeter, M.; Khater, A.; Aussere, D.

    1998-01-01

    Author.This article presents a modelisation of the distribution of a diluted solution of macromolecules submitted to a simple flow in the neighborhood of a non-absorbing solid surface. These macromolecules (length L, negligible diameter) are submitted to two kinds of forces: rotational and translational with brownian and hydrodynamic origins. The evolution of orientation of these molecules in terms of time has been studied, given Einstein equation =D with D coefficient of translation and rotation. By taking as parameters the orientation θ of the macromolecules with respect to an horizontal axis and Z the distance between these macromolecules and the surface, a statistical study has led to determine the distribution. For that reason, the brownian movement considered is supposed to follow a rule of random probability

  1. Equilibrium partitioning of macromolecules in confining geometries: Improved universality with a new molecular size parameter

    DEFF Research Database (Denmark)

    Wang, Yanwei; Peters, Günther H.J.; Hansen, Flemming Yssing

    2008-01-01

    structures (CABS), allows the computation of equilibrium partition coefficients as a function of confinement size solely based on a single sampling of the configuration space of a macromolecule in bulk. Superior in computational speed to previous computational methods, CABS is capable of handling slits...... parameter for characterization of spatial confinement effects on macromolecules. Results for the equilibrium partition coefficient in the weak confinement regime depend only on the ratio ofR-s to the confinement size regardless of molecular details....

  2. Single molecule optical measurements of orientation and rotations of biological macromolecules

    OpenAIRE

    Shroder, Deborah Y; Lippert, Lisa G; Goldman, Yale E

    2016-01-01

    The subdomains of macromolecules often undergo large orientation changes during their catalytic cycles that are essential for their activity. Tracking these rearrangements in real time opens a powerful window into the link between protein structure and functional output. Site-specific labeling of individual molecules with polarized optical probes and measuring their spatial orientation can give insight into the crucial conformational changes, dynamics, and fluctuations of macromolecules. Here...

  3. Universal aspects of macromolecules in polymer blends, solutions, and supercritical mixtures

    International Nuclear Information System (INIS)

    Melnichenko, Y.B.; Wignall, G.D.; Schwahn, D.

    2002-01-01

    We demonstrate that macromolecules in miscible polymer blends may behave as good, Θ, and poor polymeric solvents for each other. We construct a conceptual phase diagram, delineating the range of validity of the random-phase approximation, outside of which polymers contract or expand beyond their unperturbed dimensions, contrary to common assumptions. Remarkably, the correlation length for polymer blends, solutions, and supercritical mixtures collapses onto a master curve, reflecting universal behavior for macromolecules in polymeric and small-molecule Θ solvents

  4. An investigation of the shedding of macromolecules from the Ehrlich mouse ascites tumor cell

    International Nuclear Information System (INIS)

    Edwards, E.H.

    1984-01-01

    The spontaneous release, or shedding, of cell surface components into the extracellular medium may be important in the determination of several features of the cancer cell phenotype. The release of macromolecules from the Erhlich mouse ascites tumor cell was studied under a variety of experimental conditions to elucidate the origin and the underlying mechanisms of release. The extrinsic macromolecules are a diverse group with apparent molecular weights ranging from 13,500 to 400,000 daltons. External labeling of the cell surface with tritiated 4,4'-diisothiocyano-1,2-diphenylethane-2,2-disulfonic acid ([ 3 H]H 2 DIDS) reveals a slow loss of labeled components at 4 degrees C, while at 21 degrees C and 37 degrees C an initial rapid loss is followed by a slower release. In vitro metabolic labeling with [1- 14 C]-D-glucosamine hydrochloride, D-[2- 3 H]-mannose and various [ 3 H]-L-amino acids results in the appearance of labeled macromolecules in the medium suggesting tumor, not mouse, origin. These data suggest that the extrinsic macromolecules originate from the cell surface. Macromolecules are shed by a temperature and pH sensitive process. These results suggest that a limited proteolytic digestion, or sublethal autolysis, of the cell surface may occur in this system. The macromolecules shed by the Ehrlich cell originate from the surface and are probably released by sublethal autolysis, direct secretion and a passive process

  5. Science coverage and the press

    International Nuclear Information System (INIS)

    Hawkes, N.

    1992-01-01

    The writer, a journalist, summarizes the discussion of the Chilton Seminar, February 1992, and discusses the problems of bridging the incomprehension gap between scientists and lay readers of the press. (Author)

  6. Hot-pressing steatite bodies

    International Nuclear Information System (INIS)

    Aparicio Arroyo, E.

    1967-01-01

    Requirements for some special nuclear engineering ceramic shapes are: big size, impervious, dimensional accuracy and good mechanical and dielectric properties. Limitations of te conventional methods and advantages of te hot pressing techniques for the manufacturing of these shapes are discussed. Hot pressing characteristics of a certain steatite powder are studied. Occurrence of an optimum densification temperature just above the tale decomposition range is found. Experimental data show that the height/diameter ratio of the specimen has no effect on the sintering conditions. Increasing darkness from the graphite mould is detected above the optimum temperature. The hot-pressed steatite is compared with a fired dry-pressed sample of the same composition. (Author) 13 refs

  7. Mathematical modelling of wet paper pressing

    NARCIS (Netherlands)

    Bežanovic, D.

    2005-01-01

    The aim of this project is to reduce energy costs in paper production by optimising the process in the press section of a paper machine. In this press section water is squeezed as it passes through the press nip. In a modern press section the moisture content of the sheet after three or four presses

  8. Conférence de presse | Press Conference

    CERN Multimedia

    CERN. Geneva; Bejar Alonso, Isabel

    2018-01-01

    10:00-11:00 Conférence de presse en présence de Lucio Rossi, chef du projet LHC à Haute Luminosité et Isabel Bejar Alonso, chargée de la configuration, de la qualité et des ressources du projet LHC à Haute Luminosité.

  9. Investing in a Large Stretch Press

    Science.gov (United States)

    Choate, M.; Nealson, W.; Jay, G.; Buss, W.

    1986-01-01

    Press for forming large aluminum parts from plates provides substantial economies. Study assessed advantages and disadvantages of investing in large stretch-forming press, and also developed procurement specification for press.

  10. WordPress 3 Cookbook

    CERN Document Server

    Shreves, Ric

    2011-01-01

    This is a Packt Cookbook, which means it contains step-by-step instructions to achieve a particular goal or solve a particular problem. There are plenty of screenshots and explained practical tasks to make comprehension quick and easy. This book is not specifically for developers or programmers; rather it can be used by anyone who wants to get more out of their WordPress blog by following step-by-step instructions. A basic knowledge of PHP/XHTML/CSS/WordPress is desirable but not necessary.

  11. Law and the Student Press.

    Science.gov (United States)

    Stevens, George E.; Webster, John B.

    Court cases and legal decisions involving the student press in the late 1960s and early 1970s are brought together in this book in order to show how the law has been applied to school officials and student journalists in high school, college, and the underground. The ten chapters cover the following topics: censorship, libel, obscenity, contempt,…

  12. Local and international press digest

    CERN Multimedia

    2008-01-01

    The following are the top stories in the Maltese and the international press today. The Times gives prominence to the Prime Minister's flying visit to Geneva yesterday, where he signed a research cooperation agreement with CERN, the European nuclear research organisation.

  13. A new hot pressing technique

    International Nuclear Information System (INIS)

    Carcey, J.

    1975-01-01

    An original hot pressing method which may be applied to ceramics, metals, and refractory powders is described. The products obtained are fine grained polycristalline materials, with homogeneous structure, very high density, unstrained and of very large dimensions (several square meters). This process equally applies to composite materials including powders, fibers, etc.. [fr

  14. Synthesis and Characterization of a Chondroitin Sulfate Based Hybrid Bio/Synthetic Biomimetic Aggrecan Macromolecule

    Science.gov (United States)

    Sarkar, Sumona

    Lower back pain resulting from intervertebral disc degeneration is one of the leading musculoskeletal disorders confronting our health system. In order to mechanically stabilize the disc early in the degenerative cascade and prevent the need for spinal fusion surgeries, we have proposed the development of a hybrid-bio/synthetic biomimetic proteoglycan macromolecule for injection into the disc in the early stages of degeneration. The goal of this thesis was to incorporate natural chondroitin sulfate (CS) chains into bottle brush polymer synthesis strategies for the fabrication of CS-macromolecules which mimic the proteoglycan structure and function while resisting enzymatic degradation. Both the "grafting-to" and "grafting-through" techniques of bottle brush synthesis were explored. CS was immobilized via a terminal primary amine onto a model polymeric backbone (polyacrylic acid) for investigation of the "grafting-to" strategy and an epoxy-amine step-growth polymerization technique was utilized for the "grafting-through" synthesis of CS-macromolecules with polyethylene glycol backbone segments. Incorporation of a synthetic polymeric backbone at the terminal amine of CS was confirmed via biochemical assays, 1H-NMR and FTIR spectroscopy, and CS-macromolecule size was demonstrated to be higher than that of natural CS via gel permeation chromatography, transmission electron microscopy and viscosity measurements. Further analysis of CS-macromolecule functionality indicated maintenance of natural CS properties such as high fixed charge density, high osmotic potential and low cytotoxicity with nucleus pulposus cells. These studies are the first attempt at the incorporation of natural CS into biomimetic bottle brush structures. CS-macromolecules synthesized via the methods developed in these studies may be utilized in the treatment and prevention of debilitating back pain as well as act as mimetics for other proteoglycans implicated in cartilage, heart valve, and nervous

  15. Method for selective immobilization of macromolecules on self assembled monolayer surfaces

    Science.gov (United States)

    Laskin, Julia [Richland, WA; Wang, Peng [Billerica, MA

    2011-11-29

    Disclosed is a method for selective chemical binding and immobilization of macromolecules on solid supports in conjunction with self-assembled monolayer (SAM) surfaces. Immobilization involves selective binding of peptides and other macromolecules to SAM surfaces using reactive landing (RL) of mass-selected, gas phase ions. SAM surfaces provide a simple and convenient platform for tailoring chemical properties of a variety of substrates. The invention finds applications in biochemistry ranging from characterization of molecular recognition events at the amino acid level and identification of biologically active motifs in proteins, to development of novel biosensors and substrates for stimulated protein and cell adhesion.

  16. Click chemistry approach to functionalize two-dimensional macromolecules of graphene oxide nanosheets

    Institute of Scientific and Technical Information of China (English)

    Liang Kou; Hongkun He; Chao Gao

    2010-01-01

    A facile 'click chemistry' approach to functionalize 2D macromolecules of graphene oxide nanosheets with poly(ethylene glycol) of different molecular weights,polystyrene,palmitic acid and various amino acids was presented.FTIR,TGA,Raman spectroscopy,XPS,XRD,TEM,AFM and SEM were utilized to characterize the products.High degree of functionalization was achieved on the flat surfaces of graphene oxide,affording polymer-grafted 2D brushes and amino acids-immobilized nanosheets,which show improved solubility in organic solvents.The click chemistry strategy reported herein provides a facile and general method for functionalization of graphene oxide with macromolecules and desired biomolecules.

  17. Single molecule optical measurements of orientation and rotations of biological macromolecules.

    Science.gov (United States)

    Shroder, Deborah Y; Lippert, Lisa G; Goldman, Yale E

    2016-11-22

    Subdomains of macromolecules often undergo large orientation changes during their catalytic cycles that are essential for their activity. Tracking these rearrangements in real time opens a powerful window into the link between protein structure and functional output. Site-specific labeling of individual molecules with polarized optical probes and measurement of their spatial orientation can give insight into the crucial conformational changes, dynamics, and fluctuations of macromolecules. Here we describe the range of single molecule optical technologies that can extract orientation information from these probes, review the relevant types of probes and labeling techniques, and highlight the advantages and disadvantages of these technologies for addressing specific inquiries.

  18. Creatine, Glutamine plus Glutamate, and Macromolecules Are Decreased in the Central White Matter of Premature Neonates around Term.

    Directory of Open Access Journals (Sweden)

    Meriam Koob

    Full Text Available Preterm birth represents a high risk of neurodevelopmental disabilities when associated with white-matter damage. Recent studies have reported cognitive deficits in children born preterm without brain injury on MRI at term-equivalent age. Understanding the microstructural and metabolic underpinnings of these deficits is essential for their early detection. Here, we used diffusion-weighted imaging and single-voxel 1H magnetic resonance spectroscopy (MRS to compare brain maturation at term-equivalent age in premature neonates with no evidence of white matter injury on conventional MRI except diffuse excessive high-signal intensity, and normal term neonates. Thirty-two infants, 16 term neonates (mean post-conceptional age at scan: 39.8±1 weeks and 16 premature neonates (mean gestational age at birth: 29.1±2 weeks, mean post-conceptional age at scan: 39.2±1 weeks were investigated. The MRI/MRS protocol performed at 1.5T involved diffusion-weighted MRI and localized 1H-MRS with the Point RESolved Spectroscopy (PRESS sequence. Preterm neonates showed significantly higher ADC values in the temporal white matter (P<0.05, the occipital white matter (P<0.005 and the thalamus (P<0.05. The proton spectrum of the centrum semiovale was characterized by significantly lower taurine/H2O and macromolecules/H2O ratios (P<0.05 at a TE of 30 ms, and reduced (creatine+phosphocreatine/H2O and (glutamine+glutamate/H2O ratios (P<0.05 at a TE of 135 ms in the preterm neonates than in full-term neonates. Our findings indicate that premature neonates with normal conventional MRI present a delay in brain maturation affecting the white matter and the thalamus. Their brain metabolic profile is characterized by lower levels of creatine, glutamine plus glutamate, and macromolecules in the centrum semiovale, a finding suggesting altered energy metabolism and protein synthesis.

  19. A press for the theater

    Directory of Open Access Journals (Sweden)

    Luciana Penna França

    2017-12-01

    Full Text Available Understanding the history of the amateur theater at the end of the XIXth century and the beginning of the XXth is possible, largely, because of the newspapers dedicated to the “theatrical affairs”. Such publications are important for the quantity and the diversity, revealing not only the place occupied by the theater in the capital, but also for the recognition of the press as a means of disclosure of plays, public education and opinion, artist projection, etc, not to mention personal affairs and requests, and the exchange of favors among managers and journalists. Even more, the press production of the dramatic amateurs clubs demonstrate the understanding of its role in the dissemination of ways to act and think beyond the stage and in the everyday life.

  20. Pressing technology for large bottoms

    International Nuclear Information System (INIS)

    Jilek, L.

    1986-01-01

    The technology has been selected of a circular plate bent into the shape of a trough, for pressing bottoms of pressure vessels from a circular plate of large diameter. The initial sheet is first bent in the middle by heating with the edges remaining straight. These are then welded longitudinally by electroslag welding and the circular shape is flame cut. The result will be a plate with a straight surface in the middle with raised edges which may be pressed into the desired shape. In this manner it is also possible to press pressure vessel bottoms with tube couplings from plates which are thickened in the middle and drilled; additional welding is then eliminated. Deformation from heat treatment may be avoided by the use of a fixture in the shape of a ring with a groove into which is fixed the edge of the bottom. During hardening of the bottom it will be necessary to care for the withdrawal of vapours and gases which would hamper uniform cooling. Bottom hardening with the grill and the cupola downwards has been proven. Deformation which occurs during treatment may to a certain extent be removed by calibration which cannot, however, be made without special fixtures and instruments. (J.B.)

  1. Induced liquid-crystalline ordering in solutions of stiff and flexible amphiphilic macromolecules: Effect of mixture composition

    International Nuclear Information System (INIS)

    Glagolev, Mikhail K.; Vasilevskaya, Valentina V.; Khokhlov, Alexei R.

    2016-01-01

    Impact of mixture composition on self-organization in concentrated solutions of stiff helical and flexible macromolecules was studied by means of molecular dynamics simulation. The macromolecules were composed of identical amphiphilic monomer units but a fraction f of macromolecules had stiff helical backbones and the remaining chains were flexible. In poor solvents the compacted flexible macromolecules coexist with bundles or filament clusters from few intertwined stiff helical macromolecules. The increase of relative content f of helical macromolecules leads to increase of the length of helical clusters, to alignment of clusters with each other, and then to liquid-crystalline-like ordering along a single direction. The formation of filament clusters causes segregation of helical and flexible macromolecules and the alignment of the filaments induces effective liquid-like ordering of flexible macromolecules. A visual analysis and calculation of order parameter relaying the anisotropy of diffraction allow concluding that transition from disordered to liquid-crystalline state proceeds sharply at relatively low content of stiff components.

  2. A screening-corrected additivity rule for the calculation of electron scattering from macro-molecules

    International Nuclear Information System (INIS)

    Blanco, F; Garcia, G

    2009-01-01

    A simplified form of the well-known screening-corrected additivity rule procedure for the calculation of electron-molecule cross sections is proposed for the treatment of some very large macro-molecules. While the comparison of the standard and simplified treatments for a DNA dodecamer reveals very similar results, the new treatment presents some important advantages for large molecules.

  3. Probing nanoparticle-macromolecule interaction and resultant structure by small-angle neutron scattering

    International Nuclear Information System (INIS)

    Aswal, V.K.

    2013-01-01

    Nanoparticles display unique and distinct characteristics from those of their constituent atoms and bulk materials which are being employed in numerous applications in the fields of medicine, electronics, optics, communications, energy, environment etc. Many of these applications require adjoining of nanoparticles with macromolecules such as proteins, polymers and surfactants to obtain functional objects. For example, nanoparticle-protein complexes are of great importance in controlling enzymatic behavior, targeted drug delivery and developing biocompatible materials. The nanoparticles interfaced with polymers are shown to be useful in developing protein sensor arrays. Interaction of surfactants with nanoparticles is utilized extensively for technical and industrial applications associated with colloidal stability, detergency and design of nanostructured functional interfaces. The interaction of two components, nanoparticles and macromolecule, strongly depends on the characteristics of both the nanoparticles (size, shape, surface roughness, charge density etc.) and macromolecules (type, charge, shape and solution conditions etc.) used. The interaction of macromolecule on nanoparticle surface is a cumulative effect of a number of forces such as electrostatic force, covalent bonding, hydrogen bonding, non-polar interaction, hydrophobic interactions etc. These interactions depending on the system conditions can lead to various structures. Small-angle neutron scattering (SANS) with the possibility to vary contrast is an ideal technique to study such multi-component systems. In this talk, some of our results of SANS from the complexes of nanoparticle-protein and nanoparticle surfactant systems will be discussed. (author)

  4. Classification of the ejection mechanisms of charged macromolecules from liquid droplets.

    Science.gov (United States)

    Consta, Styliani; Malevanets, Anatoly

    2013-01-28

    The relation between the charge state of a macromolecule and its ejection mechanism from droplets is one of the important questions in electrospray ionization methods. In this article, effects of solvent-solute interaction on the manifestation of the charge induced instability in a droplet are examined. We studied the instabilities in a prototype system of a droplet comprised of charged poly(ethylene glycol) and methanol, acetonitrile, and water solvents. We observed instances of three, previously only conjectured, [S. Consta, J. Phys. Chem. B 114, 5263 (2010)] mechanisms of macroion ejection. The mechanism of ejection of charged macroion in methanol is reminiscent of "pearl" model in polymer physics. In acetonitrile droplets, the instability manifests through formation of solvent spines around the solvated macroion. In water, we find that the macroion is ejected from the droplet through contiguous extrusion of a part of the chain. The difference in the morphology of the instabilities is attributed to the interplay between forces arising from the macroion solvation energy and the surface energy of the droplet interface. For the contiguous extrusion of a charged macromolecule from a droplet, we demonstrate that the proposed mechanism leads to ejection of the macromolecule from droplets with sizes well below the Rayleigh limit. The ejected macromolecule may hold charge significantly higher than that suggested by prevailing theories. The simulations reveal new mechanisms of macroion evaporation that differ from conventional charge residue model and ion evaporation mechanisms.

  5. Simple and effective procedure for conformational search of macromolecules. Application to Met- and Leu-Enkephalin

    Energy Technology Data Exchange (ETDEWEB)

    Meirovitch, H.; Meirovitch, E. (Florida State Univ., Tallahassee, FL (United States)); Michel, A.G. (Institut de Recherches Serrier, Suresnes (France)); Vasquez, M. (Protein Design Lab., Mountain View, CA (United States))

    1994-06-23

    A simple and efficient method for searching the conformational space of macromolecules is presented. With this method an initial set of relatively low-energy structures is generated, and their energies are further minimized with a procedure that enables escaping from local energy minima. Illustrative calculations are described for Met- and Leu-enkephalin. 37 refs., 1 tab.

  6. Conformational properties of rigid-chain amphiphilic macromolecules : The phase diagram

    NARCIS (Netherlands)

    Markov, V. A.; Vasilevskaya, V. V.; Khalatur, P. G.; ten Brinke, G.; Khokhlov, A. R.

    The coil-globule transition in rigid-chain amphiphilic macromolecules was studied by means of computer simulation, and the phase diagrams for such molecules in the solvent quality-persistence length coordinates were constructed. It was shown that the type of phase diagram depends to a substantial

  7. Modularity of Pressing Tools for Screw Press Producing Solid Biofuels

    Directory of Open Access Journals (Sweden)

    Miloš Matúš

    2012-01-01

    Full Text Available This paper focuses on the development of the newly-patented structure of a screw briquetting machine for compacting biomass into a solid biofuel. The design of the machine is based on the results of a comprehensive study of the complicated process of biomass compaction. The patented structure meets two main goals: the elimination of axial forces, leading to increased lifetime of the bearings, and the new modular design of a pressing chamber and tools with their geometry based on the application of a mathematical model.

  8. WordPress Website Development

    OpenAIRE

    Lassila, Joonas

    2016-01-01

    The aim of this Bachelor’s thesis was to develop a WordPress mobile-first style website for the customer, Pohjois-Suomen Pesis. The main purpose of the development was to learn website designing principles and create a responsive website for the mobile and desktop platforms. The development process began defining the requirements of the website and creating the requirements document. Then next step was learning how to design a website layout and to choose the colour scheme for the site. T...

  9. Smashing WordPress Beyond the Blog

    CERN Document Server

    Hedengren, Thord Daniel

    2012-01-01

    The ultimate guide to WordPress, from the world's most popular resource for web designers and developers As one of the hottest tools on the web today for creating a blog, WordPress has evolved to be much more that just a blogging platform and has been pushed beyond its original purpose. With this new edition of a perennially popular WordPress resource, Smashing Magazine offers you the information you need so you can maximize the potential and power of WordPress. WordPress expert Thord Daniel Hedengren takes you beyond the basic blog to show you how to leverage the capabilities of WordPress to

  10. Teach yourself visually WordPress

    CERN Document Server

    Majure, Janet

    2012-01-01

    Get your blog up and running with the latest version of WordPress WordPress is one of the most popular, easy-to-use blogging platforms and allows you to create a dynamic and engaging blog, even if you have no programming skills or experience. Ideal for the visual learner, Teach Yourself VISUALLY WordPress, Second Edition introduces you to the exciting possibilities of the newest version of WordPress and helps you get started, step by step, with creating and setting up a WordPress site. Author and experienced WordPress user Janet Majure shares advice, insight, and best practices for taking full

  11. Prediction of Pressing Quality for Press-Fit Assembly Based on Press-Fit Curve and Maximum Press-Mounting Force

    Directory of Open Access Journals (Sweden)

    Bo You

    2015-01-01

    Full Text Available In order to predict pressing quality of precision press-fit assembly, press-fit curves and maximum press-mounting force of press-fit assemblies were investigated by finite element analysis (FEA. The analysis was based on a 3D Solidworks model using the real dimensions of the microparts and the subsequent FEA model that was built using ANSYS Workbench. The press-fit process could thus be simulated on the basis of static structure analysis. To verify the FEA results, experiments were carried out using a press-mounting apparatus. The results show that the press-fit curves obtained by FEA agree closely with the curves obtained using the experimental method. In addition, the maximum press-mounting force calculated by FEA agrees with that obtained by the experimental method, with the maximum deviation being 4.6%, a value that can be tolerated. The comparison shows that the press-fit curve and max press-mounting force calculated by FEA can be used for predicting the pressing quality during precision press-fit assembly.

  12. Pellet presses for remote fuel fabrication

    International Nuclear Information System (INIS)

    Densley, P.J.

    1978-01-01

    Two types of mechanical presses are being tested from the remote operation and remote maintenance aspects. Results will be used to recommend the type of press and design considerations required for operation in a remotely operated and maintained process line

  13. Press to compress contaminated wastes drums

    International Nuclear Information System (INIS)

    Prevost, J.

    1993-01-01

    This patent describes a press for contaminated wastes drums pressing. The press is made of a structure comprising a base and an upper stringer bind to the base by vertical bearers, a compression system comprising a main cylinder and a ram, connected to the upper stringer

  14. Free diffusion of translation of macromolecules in solution with the rayleigh interferometer; Diffusion libre de translation des macromolecules en solution, par interferometrie de rayleigh

    Energy Technology Data Exchange (ETDEWEB)

    Leger, J J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    The aim of this study is to develop a rapid and accurate measurement, with the Rayleigh interferometer, of the free diffusion coefficient of translation of macromolecules in solution. After having explained the choice of a diffusion cell with laminar lateral flow, and explained the principle of the Rayleigh interferometer, a semi-automatic technique of free diffusion are then introduced. Solutions are proposed for systems composed of two or three components, such as biopolymers. The paper ends by drafting the possible treatment of recorded experimental data by means of electronic computer. (author) [French] Cette etude a ete entreprise pour mettre au point une methode precise et rapide de mesure, par interferometre de Rayleigh, du coefficient de diffusion libre de translation des macromolecules en solution. Apres avoir justifie le choix d'une cellule de diffusion a ecoulement laminaire lateral et explique le principe de l'interferometre de Rayleigh, l'auteur decrit une technique semi-automatique d'enregistrement des cliches d'interference. Il introduit ensuite les equations differentielles de diffusion libre et propose des solutions pour les systemes a deux et trois composants applicables aux biopolymeres. L'article se termine par une esquisse concernant le traitement des donnees experimentales enregistrees au moyen du calcul electronique. (auteur)

  15. IDEAL: ACADEMIC PRESS JOURNALS ONLINE

    CERN Multimedia

    The Library

    2001-01-01

    All Academic Press journals are available online to CERN users for a test period which will last until the end of July. The service 'IDEALIBRARY' includes 174 scientific journals that cover several domains, ranging from engineering to mathematics, computing and physics. Titles covered are among others 'Atomic Data and Nuclear Data Tables', 'Nuclear Data Sheets', 'Annals of Physics', 'Journal of Parallel and Distributed Computing'. Reference citations present in each article are linked to the corresponding full text, when the latter is published by a member of the CrossRef consortium (members are: Elsevier, APS, AIP and others). Therefore, the navigation between articles and references is uninterrupted. A search engine allows queries by author, title and publication year. See http://www.idealibrary.com. At present the Library is evaluating a site license offer proposed by the publisher.

  16. Marine-derived biological macromolecule-based biomaterials for wound healing and skin tissue regeneration.

    Science.gov (United States)

    Chandika, Pathum; Ko, Seok-Chun; Jung, Won-Kyo

    2015-01-01

    Wound healing is a complex biological process that depends on the wound condition, the patient's health, and the physicochemical support given through external materials. The development of bioactive molecules and engineered tissue substitutes to provide physiochemical support to enhance the wound healing process plays a key role in advancing wound-care management. Thus, identification of ideal molecules in wound treatment is still in progress. The discovery of natural products that contain ideal molecules for skin tissue regeneration has been greatly advanced by exploration of the marine bioenvironment. Consequently, tremendously diverse marine organisms have become a great source of numerous biological macromolecules that can be used to develop tissue-engineered substitutes with wound healing properties. This review summarizes the wound healing process, the properties of macromolecules from marine organisms, and the involvement of these molecules in skin tissue regeneration applications. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. Interactions between macromolecule-bound antioxidants and Trolox during liposome autoxidation

    DEFF Research Database (Denmark)

    Celik, Ecem Evrim; Amigo Rubio, Jose Manuel; Andersen, Mogens Larsen

    2017-01-01

    The interactions between free and macromolecule-bound antioxidants were investigated in order to evaluate their combined effects on the antioxidant environment. Dietary fiber (DF), protein and lipid-bound antioxidants, obtained from whole wheat, soybean and olive oil products, respectively and Tr...... of logistic function was successfully used for modelling the oxidation curve of liposomes. Principal component analysis revealed two separate phases of liposome autoxidation.......The interactions between free and macromolecule-bound antioxidants were investigated in order to evaluate their combined effects on the antioxidant environment. Dietary fiber (DF), protein and lipid-bound antioxidants, obtained from whole wheat, soybean and olive oil products, respectively...... of the simple addition effects of Trolox and bound antioxidants with measured values on lipid oxidation revealed synergetic interactions for DF and refined olive oil-bound antioxidants, and antagonistic interactions for protein and extra virgin olive oil-bound antioxidants with Trolox. A generalized version...

  18. Professional WordPress design and development

    CERN Document Server

    Williams, Brad; Stern, Hal

    2014-01-01

    The highest rated WordPress development and design book on the market is back with an all new third edition. Professional WordPress is the only WordPress book targeted to developers, with advanced content that exploits the full functionality of the most popular CMS in the world. Fully updated to align with WordPress 4.1, this edition has updated examples with all new screenshots, and full exploration of additional tasks made possible by the latest tools and features. You will gain insight into real projects that currently use WordPress as an application framework, as well as the basic usage a

  19. Chemical species of iodine in some seaweeds. Pt. 2. Iodine-bound biological macromolecules

    International Nuclear Information System (INIS)

    Xiaolin Hou; Chifang Chai; Xiaojun Yan

    2000-01-01

    The distribution of iodine in various biological macromolecules in Sargassum kjellmanianum was studied using neutron activation analysis combined with chemical and biochemical separation techniques. The results indicate that iodine is mainly bound with protein, part of iodine with pigment and polyphenol, and little with polysaccharides, such as algin, fucoidan and cellulose. This result is significant for the mechanism of enriching iodine of algae and utilization of alga iodine. (author)

  20. Synthetic mimetics of the endogenous gastrointestinal nanomineral: Silent constructs that trap macromolecules for intracellular delivery.

    Science.gov (United States)

    Pele, Laetitia C; Haas, Carolin T; Hewitt, Rachel E; Robertson, Jack; Skepper, Jeremy; Brown, Andy; Hernandez-Garrido, Juan Carlos; Midgley, Paul A; Faria, Nuno; Chappell, Helen; Powell, Jonathan J

    2017-02-01

    Amorphous magnesium-substituted calcium phosphate (AMCP) nanoparticles (75-150nm) form constitutively in large numbers in the mammalian gut. Collective evidence indicates that they trap and deliver luminal macromolecules to mucosal antigen presenting cells (APCs) and facilitate gut immune homeostasis. Here, we report on a synthetic mimetic of the endogenous AMCP and show that it has marked capacity to trap macromolecules during formation. Macromolecular capture into AMCP involved incorporation as shown by STEM tomography of the synthetic AMCP particle with 5nm ultra-fine iron (III) oxohydroxide. In vitro, organic cargo-loaded synthetic AMCP was taken up by APCs and tracked to lysosomal compartments. The AMCP itself did not regulate any gene, or modify any gene regulation by its cargo, based upon whole genome transcriptomic analyses. We conclude that synthetic AMCP can efficiently trap macromolecules and deliver them to APCs in a silent fashion, and may thus represent a new platform for antigen delivery. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

  1. Prevention of H-Aggregates Formation in Cy5 Labeled Macromolecules

    Directory of Open Access Journals (Sweden)

    Jing Kang

    2010-01-01

    Full Text Available H-aggregates of the cyanine dye Cy5 are formed during covalent linkage to the cationic macromolecule Poly(allylamine (PAH. The nonfluorescent H-aggregates strongly restrict the usage of the dye for analytical purposes and prevent a quantitative determination of the labeled macromolecules. The behavior of the H-aggregates has been studied by investigation of the absorption and fluorescence spectra of the dye polymer in dependence on solvent, label degree and additional sulfonate groups. H-aggregate formation is caused by an inhomogeneous distribution of the Cy5 molecules on the polymer chain. The H-aggregates can be destroyed by conformational changes of the PAH induced by interactions with polyanions or in organic solvents. It has been found that the polymer labeling process in high content of organic solvents can prevent the formation of H-aggregates. The results offer a better understanding and improvement of the use of the Cy5 dye for labeling purposes in fluorescence detection of macromolecules.

  2. Scalable synthesis of sequence-defined, unimolecular macromolecules by Flow-IEG

    Science.gov (United States)

    Leibfarth, Frank A.; Johnson, Jeremiah A.; Jamison, Timothy F.

    2015-01-01

    We report a semiautomated synthesis of sequence and architecturally defined, unimolecular macromolecules through a marriage of multistep flow synthesis and iterative exponential growth (Flow-IEG). The Flow-IEG system performs three reactions and an in-line purification in a total residence time of under 10 min, effectively doubling the molecular weight of an oligomeric species in an uninterrupted reaction sequence. Further iterations using the Flow-IEG system enable an exponential increase in molecular weight. Incorporating a variety of monomer structures and branching units provides control over polymer sequence and architecture. The synthesis of a uniform macromolecule with a molecular weight of 4,023 g/mol is demonstrated. The user-friendly nature, scalability, and modularity of Flow-IEG provide a general strategy for the automated synthesis of sequence-defined, unimolecular macromolecules. Flow-IEG is thus an enabling tool for theory validation, structure–property studies, and advanced applications in biotechnology and materials science. PMID:26269573

  3. Friction of N-bead macromolecules in solution: Effects of the bead-solvent interaction

    International Nuclear Information System (INIS)

    Uvarov, Alexander; Fritzsche, Stephan

    2006-01-01

    The role of the bead-solvent interaction has been studied for its influence on the dynamics of an N-bead macromolecule which is immersed into a solution. Using a Fokker-Planck equation for the phase-space distribution function of the macromolecule, we show that all the effects of the solution can be treated entirely in terms of the friction tensors which are assigned to each pair of interacting beads in the chain. For the high-density as well as for the critical solvent, the properties of these tensors are discussed in detail and are calculated by using several (realistic) choices of the bead-solvent potential. From the friction tensors, moreover, an expression for the center-of-mass friction coefficient of a (N-bead) chain macromolecule is derived. Numerical data for this coefficient for 'truncated' Lennard-Jones bead-solvent potential are compared with results from molecular dynamic simulations and from the phenomenological theoretical data as found in the literature

  4. Application of Symmetry Adapted Function Method for Three-Dimensional Reconstruction of Octahedral Biological Macromolecules

    Directory of Open Access Journals (Sweden)

    Songjun Zeng

    2010-01-01

    Full Text Available A method for three-dimensional (3D reconstruction of macromolecule assembles, that is, octahedral symmetrical adapted functions (OSAFs method, was introduced in this paper and a series of formulations for reconstruction by OSAF method were derived. To verify the feasibility and advantages of the method, two octahedral symmetrical macromolecules, that is, heat shock protein Degp24 and the Red-cell L Ferritin, were utilized as examples to implement reconstruction by the OSAF method. The schedule for simulation was designed as follows: 2000 random orientated projections of single particles with predefined Euler angles and centers of origins were generated, then different levels of noises that is signal-to-noise ratio (S/N =0.1,0.5, and 0.8 were added. The structures reconstructed by the OSAF method were in good agreement with the standard models and the relative errors of the structures reconstructed by the OSAF method to standard structures were very little even for high level noise. The facts mentioned above account for that the OSAF method is feasible and efficient approach to reconstruct structures of macromolecules and have ability to suppress the influence of noise.

  5. Formation and characterization of calcium orthophosphates in the presence of two different acidic macromolecules

    Science.gov (United States)

    Pelin, Irina M.; Maier, Vasilica; Suflet, Dana M.; Popescu, Irina; Darie-Nita, Raluca N.; Aflori, Magdalena; Butnaru, Maria

    2017-10-01

    The synthetic nanocrystalline calcium orthophosphates have a notable bioactivity due to the chemical similarity with biological apatite from calcified tissues. In mineralized tissues, the highly ordered structures come from organized assemblies of biomacromolecules and inorganic nanoparticles. One of the purposes of this work was to study the effect of two types of acidic macromolecules: atelocollagen and phosphorylated curdlan onto calcium orthophosphates formation after 30 days of maturation at 2 ± 2 °C. The resulted samples after a long aging time, either calcium orthophosphates or composites, were first investigated by FT-IR spectroscopy and X-ray diffractometry and the results indicated that precipitated hydroxyapatite with low crystallinity was obtained when the synthesis was performed in the presence of phosphorylated curdlan. The macromolecules influenced the morphology of the particles as shown by scanning and transmission electron microscopy. The presence of macromolecules as demonstrated by thermal investigation also influenced the rheological properties of the samples. The second purpose of the work was to evaluate the cytotoxicity of the samples using the MTT assay, and the results revealed very good cells viability. The preliminary results are encouraging regarding the use of these materials for further tests in order to develop injectable bone substitutes.

  6. Nasal Absorption of Macromolecules from Powder Formulations and Effects of Sodium Carboxymethyl Cellulose on Their Absorption.

    Directory of Open Access Journals (Sweden)

    Akiko Tanaka

    Full Text Available The nasal absorption of macromolecules from powder formulations and the effect of sodium carboxymethyl cellulose (CMC-Na as a pharmaceutical excipient on their absorption were studied. Model macromolecules were fluorescein isothiocyanate-labeled dextran (average molecular weight of 4.4kDa, FD4 and insulin. The plasma concentration of FD4 after application of the powder containing 50% starch (control was higher than that after application of the solution, and the absorption from 50% starch powder was enhanced by the substitution of starch with CMC-Na. The fractional absorption of FD4 after administration of the CMC-Na powder formulation was 30% and 40% higher than that after administration from the solution and the starch powder, respectively. The nasal absorption of insulin from the powder and the effect of CMC-Na were similar with those of FD4. The effective absorption of FD4 and insulin after application of powder with CMC-Na could be due to the increase in the nasal residence of FD4 and insulin. No damage in the nasal mucosa or dysfunction of the mucociliary clearance was observed after application of the drug powder and CMC-Na. The present findings indicate that nasal delivery of powder formulations with the addition of CMC-Na as an excipient is a promising approach for improving the nasal absorption of macromolecules.

  7. RELATIONSHIP BETWEEN COMPACTING PRESSURE AND CONDITIONS IN PRESSING CHAMBER DURING BIOMASS PRESSING

    Directory of Open Access Journals (Sweden)

    Peter Križan

    2016-02-01

    Full Text Available In this paper, we will present the impact of the conditions in pressing chambers during the pressing of wooden briquettes. The conditions in pressing chambers can significantly impact the resulting compacting pressure required for the pressing of briquettes. In the introduction, we show which parameters of the pressing chamber during pressing can impact the resulting compacting pressure. The experiment results which are shown in this paper described the detected impact of some important pressing chamber parameters. This experiment aims to detect the pressing chamber length impact and the impact of the way of pressing. By setting the pressing conditions, we will be able to achieve the suitable resulting compacting pressure with respect to the required final briquettes quality.

  8. Towards a more responsible press

    Directory of Open Access Journals (Sweden)

    Taimur ul Hassan

    2012-12-01

    Full Text Available The article analyses Pakistan’s newspapers’ performance with regard to civil society in2003 by using content analysis approach. There is no gainsaying that a strong civil society guaranteesa strong democracy. In Pakistan, spells of military rule have stunted the growth of democracy,adversely affecting civil society. Media too has suffered as a result. Normative theories of media callfor laying down norms and conventions for media. In democracy, all sections of society should berepresented in media. In Pakistan’s case, due to military regimes and quasi democratic governments,combined with the demands of market economy, the media have largely not been able to fulfill thisresponsibility towards society. Social Responsibility demands that the media must fulfill itsresponsibility towards society, while giving a free space to all voices of society. In Pakistan, whethernewspapers played that role in 2003 when civil society had accelerated its campaign to end honorkillings and crimes against women is investigated. The findings show that newspapers did supportcivil society, showing a gradual movement towards a more responsible press.

  9. Press Advertising – Varieties and Sub-Varieties. Methods of Promoting the Press

    OpenAIRE

    Mikosz, Joanna

    2016-01-01

    In the text entitled “Press advertising – varieties and sub-varieties. Methods of promoting the press”, the author discusses press advertising, which is a fast developing mass-media phenomenon. Modernity has granted press advertising a high quality of print and paper, as well as Infinite possibilities of combining various promotional forms with the press. The author argues that press advertising is one of the best ways in which a company can communicate with the market. Its advantage is, abov...

  10. Lignin Macromolecule

    Indian Academy of Sciences (India)

    plant or a structural component of a mature plant which is detected by certain colour reactions. An enzymologist has termed lignin as the ... a phenyl-propanoid structure. A soil chemist considers lignin to be the residue of .... refer to the hardness of wood, but to the botanical classifications. They are aptly called gymnosperms ...

  11. Smashing WordPress Beyond the Blog

    CERN Document Server

    Hedengren, Thord Daniel

    2011-01-01

    Smashing WordPress shows you how to utilize the power of the WordPress platform, and provides a creative spark to help you build WordPress-powered sites that go beyond the obvious. The second edition of Smashing WordPress has been updated for WordPress 3.1+, which includes internal, custom post types, the admin bar, and lots of other useful new features. You will learn the core concepts used to post types, the admin bar, and lots of other useful new features. You will learn the core concepts used to build just about anything in WordPress, resulting in fast deployments and greater design flexib

  12. PRESS FREEDOM IN SINGAPORE AND MALAYSIA: DEFAMATION

    OpenAIRE

    Georgia Kate Chapman

    2015-01-01

    This paper focuses on the arguments around restriction on freedom of the press in the Strong States of Singapore and Malaysia. It assesses the presence of constraints on press freedoms in democratic western countries imposed by corporation rather than state and the similar effects that these constraints may have on bias present in publicly accessible news reporting. It argues that independence of the press does not just require protection from legal and executive regulation, but also protecti...

  13. Microplasticity in hot-pressed beryllium

    International Nuclear Information System (INIS)

    Plane, D.C.; Bonfield, W.

    1977-01-01

    Closed hysteresis loops measured in the microstrain region of hot pressed, commercially pure, polycrystalline beryllium are correlated with a dislocation - impurity atom, energy dissipating mechanism. (author)

  14. WordPress 3.7 complete

    CERN Document Server

    Król, Karol

    2013-01-01

    WordPress 3.5 Complete: Third Edition is a comprehensive and step-by-step tutorial packed with screenshots and examples to make it easy and quick to pick it up.This WordPress book is a guide to WordPress for online publishers and web developers. If you are new to blogging and want to create your own blog or website from scratch, then ""WordPress 3.5 Complete: Third Edition"" is for you. No prior knowledge of HTML/CSS or PHP is required.

  15. Activation of Selected Core Muscles during Pressing

    Directory of Open Access Journals (Sweden)

    Thomas W. Nesser

    2015-10-01

    Full Text Available Introduction: Unstable surface training is often used to activate core musculature during resistance training. Unfortunately, unstable surface training is risky and leads to detraining. Purpose: The purpose of this study was to determine core muscle activation during stable surface ground-based lifts. Methods: Fourteen recreational trained and former NCAA DI athletes (weight 84.2 ± 13.3 kg; height 176.0 ± 9.5 cm; age 20.9 ± 2.0 years volunteered for participation. Subjects completed two ground-based lifts: overhead press and push-press. Surface EMG was recorded from 4 muscles on the right side of the body (Rectus Abdominus (RA, External Oblique (EO, Transverse Abdominus (TA, and Erector Spinae (ES. Results: Paired sample T-tests identified significant muscle activation differences between the overhead press and the push-press included ES and EO. Average and peak EMG for ES was significantly greater in push-press (P<0.01. Anterior displacement of COP was significantly greater in push-press compared to overhead press during the eccentric phase. Conclusion: The push-press was identified as superior in core muscle activation when compared to the overhead pressing exercise. Keywords: torso, stability, weight lifting, resistance training

  16. Increased Plasma Colloid Osmotic Pressure Facilitates the Uptake of Therapeutic Macromolecules in a Xenograft Tumor Model

    Directory of Open Access Journals (Sweden)

    Matthias Hofmann

    2009-08-01

    Full Text Available Elevated tumor interstitial fluid pressure (TIFP is a characteristic of most solid tumors. Clinically, TIFP may hamper the uptake of chemotherapeutic drugs into the tumor tissue reducing their therapeutic efficacy. In this study, a means of modulating TIFP to increase the flux of macromolecules into tumor tissue is presented, which is based on the rationale that elevated plasma colloid osmotic pressure (COP pulls water from tumor interstitium lowering the TIFP. Concentrated human serum albumin: (20% HSA, used as an agent to enhance COP, reduced the TIFP time-dependently from 8 to 2 mm Hg in human tumor xenograft models bearing A431 epidermoid vulva carcinomas. To evaluate whether this reduction facilitates the uptake of macromolecules, the intratumoral distribution of fluorescently conjugated dextrans (2.5 mg/ml and cetuximab (2.0 mg/ml was probed using novel time domain nearinfrared fluorescence imaging. This method permitted discrimination and semiquantification of tumor-accumulated conjugate from background and unspecific probe fluorescence. The coadministration of 20% HSA together with either dextrans or cetuximab was found to lower the TIFP significantly and increase the concentration of the substances within the tumor tissue in comparison to control tumors. Furthermore, combined administration of 20%HSA plus cetuximab reduced the tumor growth significantly in comparison to standard cetuximab treatment. These data demonstrate that increased COP lowers the TIFP within hours and increases the uptake of therapeutic macromolecules into the tumor interstitium leading to reduced tumor growth. This model represents a novel approach to facilitate the delivery of therapeutics into tumor tissue, particularly monoclonal antibodies.

  17. Visualization of three pathways for macromolecule transport across cultured endothelium and their modification by flow.

    Science.gov (United States)

    Ghim, Mean; Alpresa, Paola; Yang, Sung-Wook; Braakman, Sietse T; Gray, Stephen G; Sherwin, Spencer J; van Reeuwijk, Maarten; Weinberg, Peter D

    2017-11-01

    Transport of macromolecules across vascular endothelium and its modification by fluid mechanical forces are important for normal tissue function and in the development of atherosclerosis. However, the routes by which macromolecules cross endothelium, the hemodynamic stresses that maintain endothelial physiology or trigger disease, and the dependence of transendothelial transport on hemodynamic stresses are controversial. We visualized pathways for macromolecule transport and determined the effect on these pathways of different types of flow. Endothelial monolayers were cultured under static conditions or on an orbital shaker producing different flow profiles in different parts of the wells. Fluorescent tracers that bound to the substrate after crossing the endothelium were used to identify transport pathways. Maps of tracer distribution were compared with numerical simulations of flow to determine effects of different shear stress metrics on permeability. Albumin-sized tracers dominantly crossed the cultured endothelium via junctions between neighboring cells, high-density lipoprotein-sized tracers crossed at tricellular junctions, and low-density lipoprotein-sized tracers crossed through cells. Cells aligned close to the angle that minimized shear stresses across their long axis. The rate of paracellular transport under flow correlated with the magnitude of these minimized transverse stresses, whereas transport across cells was uniformly reduced by all types of flow. These results contradict the long-standing two-pore theory of solute transport across microvessel walls and the consensus view that endothelial cells align with the mean shear vector. They suggest that endothelial cells minimize transverse shear, supporting its postulated proatherogenic role. Preliminary data show that similar tracer techniques are practicable in vivo. NEW & NOTEWORTHY Solutes of increasing size crossed cultured endothelium through intercellular junctions, through tricellular

  18. Free diffusion of translation of macromolecules in solution with the rayleigh interferometer

    International Nuclear Information System (INIS)

    Leger, J.J.

    1969-01-01

    The aim of this study is to develop a rapid and accurate measurement, with the Rayleigh interferometer, of the free diffusion coefficient of translation of macromolecules in solution. After having explained the choice of a diffusion cell with laminar lateral flow, and explained the principle of the Rayleigh interferometer, a semi-automatic technique of free diffusion are then introduced. Solutions are proposed for systems composed of two or three components, such as biopolymers. The paper ends by drafting the possible treatment of recorded experimental data by means of electronic computer. (author) [fr

  19. Isolation of cell nuclei using inert macromolecules to mimic the crowded cytoplasm.

    Directory of Open Access Journals (Sweden)

    Ronald Hancock

    Full Text Available Cell nuclei are commonly isolated and studied in media which include millimolar concentrations of cations, which conserve the nuclear volume by screening the negative charges on chromatin and maintaining its compaction. However, two factors question if these ionic conditions correctly reproduce the environment of nuclei in vivo: the small-scale motion and conformation of chromatin in vivo are not reproduced in isolated nuclei, and experiments and theory suggest that small ions in the cytoplasm are not free in the soluble phase but are predominantly bound to macromolecules. We studied the possible role in maintaining the structure and functions of nuclei in vivo of a further but frequently overlooked property of the cytoplasm, the crowding or osmotic effects caused by diffusible macromolecules whose concentration, measured in several studies, is in the range of 130 mg/ml. Nuclei which conserved their volume in the cell and their ultrastructure seen by electron microscopy were released from K562 cells in media containing the inert polymer 70 kDa Ficoll (50% w/v or 70 kDa dextran (35% w/v to replace the diffusible cytoplasmic molecules which were dispersed on cell lysis with digitonin, with 100 microM K-Hepes buffer as the only source of ions. Immunofluorescence labelling and experiments using cells expressing GFP-fusion proteins showed that internal compartments (nucleoli, PML and coiled bodies, foci of RNA polymerase II were conserved in these nuclei, and nascent RNA transcripts could be elongated. Our observations are consistent with the hypothesis that crowding by diffusible cytoplasmic macromolecules is a crucial but overlooked factor which supports the nucleus in vivo by equilibrating the opposing osmotic pressure cause by the high concentration of macromolecules in the nucleus, and suggest that crowded media provide more physiological conditions to study nuclear structure and functions. They may also help to resolve the long-standing paradox

  20. Teenagers as Victims in the Press

    Science.gov (United States)

    Andersson, Gunvor; Lundstrom, Tommy

    2007-01-01

    Research into press reporting on young people has tended to concentrate on young people as offenders. In contrast, this article focuses on press coverage of teenagers as victims. Reports in two Swedish newspapers (a morning broadsheet and an evening tabloid) were studied over a period of four months and subjected to a qualitative analysis of…

  1. Communicators take nine Virginia Press Women awards

    OpenAIRE

    Owczarski, Mark

    2008-01-01

    Three Virginia Tech communicators have won Virginia Press Women awards. The winners - Susan Trulove, research division communications manager; Clara Cox, university publications director; and Heather Riley Chadwick, College of Architecture and Urban Studies communication manager - were announced at the Virginia Press Women Annual Spring Conference in Staunton, Va.

  2. 1979: The Campus Student Press in America.

    Science.gov (United States)

    Ingelhart, Louis E.

    1979-01-01

    Discusses a number of topics involving the campus press, including the independence of campus publications, censorship issues, the relationship between the student press and the college administrator, the financing of student newspapers, yearbook production and financing, probable future student publications trends, and the need for appropriate…

  3. Food macromolecule based nanodelivery systems for enhancing the bioavailability of polyphenols

    Directory of Open Access Journals (Sweden)

    Bing Hu

    2017-01-01

    Full Text Available Diet polyphenols—primarily categorized into flavonoids (e.g., flavonols, flavones, flavan-3-ols, anthocyanidins, flavanones, and isoflavones and nonflavonoids (with major subclasses of stilbenes and phenolic acids—are reported to have health-promoting effects, such as antioxidant, antiinflammatory, anticarcinoma, antimicrobial, antiviral, and cardioprotective properties. However, their applications in functional foods or medicine are limited because of their inefficient systemic delivery and poor oral bioavailability. Epigallocatechin-3-gallate, curcumin, and resveratrol are the well-known representatives of the bioactive diet polyphenols but with poor bioavailability. Food macromolecule based nanoparticles have been fabricated using reassembled proteins, crosslinked polysaccharides, protein–polysaccharide conjugates (complexes, as well as emulsified lipid via safe procedures that could be applied in food. The human gastrointestinal digestion tract is the first place where the food grade macromolecule nanoparticles exert their effects on improving the bioavailability of diet polyphenols, via enhancing their solubility, preventing their degradation in the intestinal environment, elevating the permeation in small intestine, and even increasing their contents in the bloodstream. We contend that the stability and structure behaviors of nanocarriers in the gastrointestinal tract environment and the effects of nanoencapsulation on the metabolism of polyphenols warrant more focused attention in further studies.

  4. Ordered mesoporous polymer-silica hybrid nanoparticles as vehicles for the intracellular controlled release of macromolecules.

    Science.gov (United States)

    Kim, Tae-Wan; Slowing, Igor I; Chung, Po-Wen; Lin, Victor Shang-Yi

    2011-01-25

    A two-dimensional hexagonal ordered mesoporous polymer-silica hybrid nanoparticle (PSN) material was synthesized by polymerization of acrylate monomers on the surface of SBA-15 mesoporous silica nanoparticles. The structure of the PSN material was analyzed using a series of different techniques, including transmission electron microscopy, powder X-ray diffraction, and N(2) sorption analysis. These structurally ordered mesoporous polymer-silica hybrid nanoparticles were used for the controlled release of membrane-impermeable macromolecules inside eukaryotic cells. The cellular uptake efficiency and biocompatibility of PSN with human cervical cancer cells (HeLa) were investigated. Our results show that the inhibitory concentration (IC(50)) of PSN is very high (>100 μg/mL per million cells), while the median effective concentration for the uptake (EC(50)) of PSN is low (EC(50) = 4.4 μg/mL), indicating that PSNs are fairly biocompatible and easily up-taken in vitro. A membrane-impermeable macromolecule, 40 kDa FITC-Dextran, was loaded into the mesopores of PSNs at low pH. We demonstrated that the PSN material could indeed serve as a transmembrane carrier for the controlled release of FITC-Dextran at the pH level inside live HeLa cells. We believe that further developments of this PSN material will lead to a new generation of nanodevices for intracellular controlled delivery applications.

  5. Distribution volumes of macromolecules in human ovarian and endometrial cancers--effects of extracellular matrix structure.

    Science.gov (United States)

    Haslene-Hox, Hanne; Oveland, Eystein; Woie, Kathrine; Salvesen, Helga B; Tenstad, Olav; Wiig, Helge

    2015-01-01

    Elements of the extracellular matrix (ECM), notably collagen and glucosaminoglycans, will restrict part of the space available for soluble macromolecules simply because the molecules cannot occupy the same space. This phenomenon may influence macromolecular drug uptake. To study the influence of steric and charge effects of the ECM on the distribution volumes of macromolecules in human healthy and malignant gynecologic tissues we used as probes 15 abundant plasma proteins quantified by high-resolution mass spectrometry. The available distribution volume (VA) of albumin was increased in ovarian carcinoma compared with healthy ovarian tissue. Furthermore, VA of plasma proteins between 40 and 190 kDa decreased with size for endometrial carcinoma and healthy ovarian tissue, but was independent of molecular weight for the ovarian carcinomas. An effect of charge on distribution volume was only found in healthy ovaries, which had lower hydration and high collagen content, indicating that a condensed interstitium increases the influence of negative charges. A number of earlier suggested biomarker candidates were detected in increased amounts in malignant tissue, e.g., stathmin and spindlin-1, showing that interstitial fluid, even when unfractionated, can be a valuable source for tissue-specific proteins. We demonstrate that the distribution of abundant plasma proteins in the interstitium can be elucidated by mass spectrometry methods and depends markedly on hydration and ECM structure. Our data can be used in modeling of drug uptake, and give indications on ECM components to be targeted to increase the uptake of macromolecular substances. Copyright © 2015 the American Physiological Society.

  6. A stochastic finite element model for the dynamics of globular macromolecules

    Science.gov (United States)

    Oliver, Robin C.; Read, Daniel J.; Harlen, Oliver G.; Harris, Sarah A.

    2013-04-01

    We describe a novel coarse-grained simulation method for modelling the dynamics of globular macromolecules, such as proteins. The macromolecule is treated as a continuum that is subject to thermal fluctuations. The model includes a non-linear treatment of elasticity and viscosity with thermal noise that is solved using finite element analysis. We have validated the method by demonstrating that the model provides average kinetic and potential energies that are in agreement with the classical equipartition theorem and that the nodal velocities have the correct Gaussian distribution. In addition, we have performed Fourier analysis on the simulation trajectories obtained for a series of linear beams to confirm that the correct average energies are present in the first two Fourier bending modes and that the probability distribution of the amplitudes of the first two Fourier modes match the theoretical results. We demonstrate spatial convergence of the model by showing that the anisotropy of the inertia tensor for a cubic mesh converges as a function of the mesh resolution. We have then used the new modelling method to simulate the thermal fluctuations of a representative protein over 500 ns timescales. Using reasonable parameters for the material properties, we have demonstrated that the overall deformation of the biomolecule is consistent with the results obtained for proteins in general from atomistic molecular dynamics simulations.

  7. Two modified versions of the speciation code PHREEQE for modelling macromolecule-proton/cation interaction

    International Nuclear Information System (INIS)

    Falck, W.E.

    1991-01-01

    There is a growing need to consider the influence of organic macromolecules on the speciation of ions in natural waters. It is recognized that a simple discrete ligand approach to the binding of protons/cations to organic macromolecules is not appropriate to represent heterogeneities of binding site distributions. A more realistic approach has been incorporated into the speciation code PHREEQE which retains the discrete ligand approach but modifies the binding intensities using an electrostatic (surface complexation) model. To allow for different conformations of natural organic material two alternative concepts have been incorporated: it is assumed that (a) the organic molecules form rigid, impenetrable spheres, and (b) the organic molecules form flat surfaces. The former concept will be more appropriate for molecules in the smaller size range, while the latter will be more representative for larger size molecules or organic surface coatings. The theoretical concept is discussed and the relevant changes to the standard PHREEQE code are explained. The modified codes are called PHREEQEO-RS and PHREEQEO-FS for the rigid-sphere and flat-surface models respectively. Improved output facilities for data transfer to other computers, e.g. the Macintosh, are introduced. Examples where the model is tested against literature data are shown and practical problems are discussed. Appendices contain listings of the modified subroutines GAMMA and PTOT, an example input file and an example command procedure to run the codes on VAX computers

  8. Exciton Scattering approach for conjugated macromolecules: from electronic spectra to electron-phonon coupling

    Science.gov (United States)

    Tretiak, Sergei

    2014-03-01

    The exciton scattering (ES) technique is a multiscale approach developed for efficient calculations of excited-state electronic structure and optical spectra in low-dimensional conjugated macromolecules. Within the ES method, the electronic excitations in the molecular structure are attributed to standing waves representing quantum quasi-particles (excitons), which reside on the graph. The exciton propagation on the linear segments is characterized by the exciton dispersion, whereas the exciton scattering on the branching centers is determined by the energy-dependent scattering matrices. Using these ES energetic parameters, the excitation energies are then found by solving a set of generalized ``particle in a box'' problems on the graph that represents the molecule. All parameters can be extracted from quantum-chemical computations of small molecular fragments and tabulated in the ES library for further applications. Subsequently, spectroscopic modeling for any macrostructure within considered molecular family could be performed with negligible numerical effort. The exciton scattering properties of molecular vertices can be further described by tight-binding or equivalently lattice models. The on-site energies and hopping constants are obtained from the exciton dispersion and scattering matrices. Such tight-binding model approach is particularly useful to describe the exciton-phonon coupling, energetic disorder and incoherent energy transfer in large branched conjugated molecules. Overall the ES applications accurately reproduce the optical spectra compared to the reference quantum chemistry results, and make possible to predict spectra of complex macromolecules, where conventional electronic structure calculations are unfeasible.

  9. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.

    Science.gov (United States)

    Aspelund, Aleksanteri; Antila, Salli; Proulx, Steven T; Karlsen, Tine Veronica; Karaman, Sinem; Detmar, Michael; Wiig, Helge; Alitalo, Kari

    2015-06-29

    The central nervous system (CNS) is considered an organ devoid of lymphatic vasculature. Yet, part of the cerebrospinal fluid (CSF) drains into the cervical lymph nodes (LNs). The mechanism of CSF entry into the LNs has been unclear. Here we report the surprising finding of a lymphatic vessel network in the dura mater of the mouse brain. We show that dural lymphatic vessels absorb CSF from the adjacent subarachnoid space and brain interstitial fluid (ISF) via the glymphatic system. Dural lymphatic vessels transport fluid into deep cervical LNs (dcLNs) via foramina at the base of the skull. In a transgenic mouse model expressing a VEGF-C/D trap and displaying complete aplasia of the dural lymphatic vessels, macromolecule clearance from the brain was attenuated and transport from the subarachnoid space into dcLNs was abrogated. Surprisingly, brain ISF pressure and water content were unaffected. Overall, these findings indicate that the mechanism of CSF flow into the dcLNs is directly via an adjacent dural lymphatic network, which may be important for the clearance of macromolecules from the brain. Importantly, these results call for a reexamination of the role of the lymphatic system in CNS physiology and disease. © 2015 Aspelund et al.

  10. Flocculation of colloidal clay by bacterial polysaccharides: effect of macromolecule charge and structure.

    Science.gov (United States)

    Labille, J; Thomas, F; Milas, M; Vanhaverbeke, C

    2005-04-01

    The molecular mechanism of montmorillonite flocculation by bacterial polysaccharides was investigated, with special emphasis on the effect of carboxylic charges in the macromolecules on the mechanisms of interaction with the clay surface. An indirect way to quantify the energy of interaction was used, by comparing the flocculation ability of variously acidic polysaccharides. Data on tensile strength of aggregates in diluted suspension were collected by timed size measurements in the domain 0.1-600 microm, using laser diffraction. The flow behavior of settled aggregates was studied by rheology measurements. Flocculation of colloidal clay suspension by polysaccharides requires cancelling of the electrostatic repulsions by salts, which allows approach of clay surfaces close enough to be bridged by adsorbing macromolecules. The amount of acidic charges of the polysaccharides, and especially their location in the molecular structure, governs the bridging mechanism and the resulting tensile strength of the aggregates. The exposure of carboxylate groups located on side chains strongly promotes flocculation. In turn, charges located on the backbone of the polysaccharide are less accessible to interaction, and the flocculation ability of such polysaccharides is lowered. Measurements at different pH indicate that adsorption of acidic polysaccharides occurs via electrostatic interactions on the amphoteric edge surface of clay platelets, whereas neutral polysaccharides rather adsorb via weak interactions. Increased tensile strength in diluted aggregates due to strong surface interactions results in proportionally increased viscosity of the concentrated aggregates.

  11. Multifunctional gadolinium-based dendritic macromolecules as liver targeting imaging probes.

    Science.gov (United States)

    Luo, Kui; Liu, Gang; He, Bin; Wu, Yao; Gong, Qingyong; Song, Bin; Ai, Hua; Gu, Zhongwei

    2011-04-01

    The quest for highly efficient and safe contrast agents has become the key factor for successful application of magnetic resonance imaging (MRI). The gadolinium (Gd) based dendritic macromolecules, with precise and tunable nanoscopic sizes, are excellent candidates as multivalent MRI probes. In this paper, a novel series of Gd-based multifunctional peptide dendritic probes (generation 2, 3, and 4) possessing highly controlled structures and single molecular weight were designed and prepared as liver MRI probes. These macromolecular Gd-ligand agents exhibited up to 3-fold increase in T(1) relaxivity comparing to Gd-DTPA complexes. No obvious in vitro cytotoxicity was observed from the measured concentrations. These dendritic probes were further functionalized with multiple galactosyl moieties and led to much higher cell uptake in vitro as demonstrated in T(1)-weighted scans. During in vivo animal studies, the probes provided better signal intensity (SI) enhancement in mouse liver, especially at 60 min post-injection, with the most efficient enhancement from the galactosyl moiety decorated third generation dendrimer. The imaging results were verified with analysis of Gd content in liver tissues. The design strategy of multifunctional Gd-ligand peptide dendritic macromolecules in this study may be used for developing other sensitive MRI probes with targeting capability. Copyright © 2011 Elsevier Ltd. All rights reserved.

  12. WordPress web design for dummies

    CERN Document Server

    Sabin-Wilson, Lisa

    2013-01-01

    Updated, full-color guide to creating dynamic websites with WordPress 3.6 In this updated new edition, bestselling For Dummies author and WordPress expert Lisa Sabin-Wilson makes it easy for anyone with a basic knowledge of the WordPress software to create a custom site using complementary technologies such as CSS, HTML, PHP, and MySQL. You'll not only get up to speed on essential tools and technologies and further advance your own design skills, this book also gives you pages of great case studies, so you can see just how other companies and individuals are creating compelling, customized, a

  13. Teach yourself visually complete WordPress

    CERN Document Server

    Majure, Janet

    2013-01-01

    Take your WordPress skills to the next level with these tips, tricks, and tasks Congratulations on getting your blog up and running with WordPress! Now are you ready to take it to the next level? Teach Yourself VISUALLY Complete WordPress takes you beyond the blogging basics with expanded tips, tricks, and techniques with clear, step-by-step instructions accompanied by screen shots. This visual book shows you how to incorporate forums, use RSS, obtain and review analytics, work with tools like Google AdSense, and much more.Shows you how to use mobile tools to edit a

  14. WordPress 24-Hour Trainer

    CERN Document Server

    Plumley, George

    2011-01-01

    The eagerly anticipated second edition, completely updated for WordPress 3.1 As an open source content management system, WordPress allows users to easily build feature-rich web sites with no programming experience. This unique book-and-video package is a friendly, self-paced beginners guide to the latest release of WordPress. Lessons are focused on practical, everyday tasks that users will need to create and maintain their sites: entering new content, creating new pages, managing menus, making content search-engine friendly. Plus you'll find lots of tips based on years of experience teaching

  15. WordPress web application development

    CERN Document Server

    Ratnayake, Rakhitha Nimesh

    2013-01-01

    An extensive, practical guide that explains how to adapt WordPress features, both conventional and trending, for web applications.This book is intended for WordPress developers and designers who have the desire to go beyond conventional website development to develop quality web applications within a limited time frame and for maximum profit. Experienced web developers who are looking for a framework for rapid application development will also find this to be a useful resource. Prior knowledge with of WordPress is preferable as the main focus will be on explaining methods for adapting WordPres

  16. Professional WordPress Plugin Development

    CERN Document Server

    Williams, Brad; Tadlock, Justin

    2011-01-01

    Taking WordPress to the next level with advanced plugin developmentWordPress is used to create self-hosted blogs and sites, and it's fast becoming the most popular content management system (CMS) on the Web. Now you can extend it for personal, corporate and enterprise use with advanced plugins and this professional development guide. Learn how to create plugins using the WordPress plugin API: utilize hooks, store custom settings, craft translation files, secure your plugins, set custom user roles, integrate widgets, work with JavaScript and AJAX, create custom post types. You'll find a practic

  17. Study of Servo Press with a Flywheel

    Science.gov (United States)

    Tso, Pei-Lum; Li, Cheng-Ho

    The servo press with a flywheel is able to provide flexible motions with energy-saving merit, but its true potential has not been thoroughly studied and verified. In this paper, such the “hybrid-driven” servo press is focused on, and the stamping capacity and the energy distribution between the flywheel and the servomotor are investigated. The capacity is derived based on the principle of energy conservation, and a method of using a capacity percentage plane for evaluation is proposed. A case study is included to illustrate and interpret that the stamping capacity is highly dependent on the programmed punch motions, thus the capacity prediction is always necessary while applying this kind of servo press. The energy distribution is validated by blanking experiments, and the results indicate that the servomotor needs only to provide 15% to the flywheel torque, 12% of the total stamping energy. This validates that the servomotor power is significantly saved in comparison with conventional servo presses.

  18. WordPress 3 For Business Bloggers

    CERN Document Server

    Thewlis, Paul

    2011-01-01

    This is a practical, hands-on book based around a fictitious case study blog, which you will build on a development server using WordPress. The case study grows chapter by chapter, from installing your local development server, right up to the finished blog. This book is for anybody running or starting a business blog using WordPress, whether you plan to use your blog for PR and marketing, or want to profit directly from blogging.

  19. Denmark, Democracy and the Free Press

    DEFF Research Database (Denmark)

    Breiting, Søren

    2006-01-01

    What's important to Danish people in Denmark and in the world - most will argue for the importance of a free critical press, solidarity with people who need help and a peaceful world.......What's important to Danish people in Denmark and in the world - most will argue for the importance of a free critical press, solidarity with people who need help and a peaceful world....

  20. The Liberal Struggle for Press Freedom

    DEFF Research Database (Denmark)

    Mogensen, Kirsten

    In this paper, the public debate following the re-ligion-motivated assassination of Dutch filmmaker Theo van Gogh in November 2004 is examined. The paper aims at describ-ing religious as well as secular positions in the Danish debate about freedom of speech and press in relation to religious issues....... Historically, the concept of press freedom was linked to a fight for religious freedom in London, as described by Siebert....

  1. Chip compacting press; Jido kirikuzu asshukuki

    Energy Technology Data Exchange (ETDEWEB)

    Oura, K. [Yuken Kogyo Co. Ltd., Kanagawa (Japan)

    1998-08-15

    The chips exhausted from various machine tools are massy, occupy much space and make working environment worse by staying added cutting oil to lower part. The chips are exhausted as a result of machining and have not constant quality. Even if used material is same the chips have various shapes and properties by kinds and machining methods of used machine tools, and are troublesome materials from a standpoint of their treatment. Pressing and solidification of the chips have frequently been tried. A chip compacting press introduced in this paper, a relatively cheap chip compacting press aimed for relatively small scale chip treatment, and has such characteristics and effects as follows. Chips are pressed and solidified by each raw material, so fractional management can be easily conducted. As casting metal chips and curled chips of iron and aluminum can be pressed to about 1/3 to 1/5 and about 1/40, respectively, space saving can be conducted. Chip compacting pressing upgrades its transporting efficiency to make possible to reduce its transporting cost. As chip solidification controls its oxidation and most cutting oil are removed, chips are easy to recycle. 2 figs., 1 tab.

  2. Estimating absolute configurational entropies of macromolecules: the minimally coupled subspace approach.

    Directory of Open Access Journals (Sweden)

    Ulf Hensen

    Full Text Available We develop a general minimally coupled subspace approach (MCSA to compute absolute entropies of macromolecules, such as proteins, from computer generated canonical ensembles. Our approach overcomes limitations of current estimates such as the quasi-harmonic approximation which neglects non-linear and higher-order correlations as well as multi-minima characteristics of protein energy landscapes. Here, Full Correlation Analysis, adaptive kernel density estimation, and mutual information expansions are combined and high accuracy is demonstrated for a number of test systems ranging from alkanes to a 14 residue peptide. We further computed the configurational entropy for the full 67-residue cofactor of the TATA box binding protein illustrating that MCSA yields improved results also for large macromolecular systems.

  3. A Biology Laboratory Exercise Using Macromolecule Assays to Distinguish Four Types of Milk

    Directory of Open Access Journals (Sweden)

    Charlotte W. Pratt

    2011-03-01

    Full Text Available One of the drawbacks of cookbook-style laboratory exercises for General Biology courses is that students are not challenged to develop skills in scientific reasoning, such as formulating hypotheses and designing and carrying out experiments. Several traditional laboratory curricula include exercises involving semi-quantitative colorimetric assays to detect proteins (biuret test, reducing sugars (Benedict’s test, starch (Lugol’s test, and lipids (Sudan red test in a variety of easily prepared solutions (glucose, albumin, glycine, etc. and familiar food items (lemon juice, cornstarch, egg white, etc.. An extension of this lab exercise was developed to allow students to use their knowledge of the macromolecule assays to design an experiment to distinguish four types of “milk”: whole milk, skim milk, cream, and soy milk (rice milk or almond milk could also be included.

  4. NATO Advanced Research Workshop on Nuclear Magnetic Resonance of Paramagnetic Macromolecules

    CERN Document Server

    1995-01-01

    Since A. Kowalsky's first report of the spectrum of cytochrome c in 1965, interest in the detection, assignment and interpretation of paramagnetic molecules has surged, especially in the last decade. Two classes of systems have played a key role in the development of the field: heme proteins and iron-sulfur proteins. These two systems are unique in many respects, one of which is that they contain well-defined chromophores, each of which can be studied in detail outside the protein matrix. They are the most successfully studied macromolecules, and the first eight and last six of the seventeen contributions to this book deal with heme and/or iron-sulfur proteins. The middle three chapters survey the progress on, and significant promise of, more difficult systems which do not possess a chromophore, but which have nevertheless yielded remarkable insights into their structure.

  5. Synthesis of macromolecules by the epithelial surfaces of Schistosoma mansoni: an autoradiographic study

    International Nuclear Information System (INIS)

    Wilson, R.A.; Barnes, P.E.

    1979-01-01

    The use of tritiated leucine as a marker for protein synthesis and of tritiated glucosamine as a marker for polysaccharide/glycoprotein synthesis, is described. Adult worms were pulse-labelled by incubation in medium containing the substrate. Labelled worms were then incubated in chase medium, without labelled substrate, for varying lengths of time before fixation. The distribution of label which had been incorporated into macromolecules in the worm tissues, was examined by light and electron microscope autoradiography. The results suggest that the bulk of worm secretions have a rapid turnover with a half-life of a few hours. Against this background of rapid mass secretion, a slower process of membrane turnover would be difficult to detect and quantitatively small. (author)

  6. Conformations of polyelectrolyte macromolecules with different charge density in solutions of different ionic strengths

    International Nuclear Information System (INIS)

    Dommes, O A; Okatova, O V; Pavlov, G M

    2016-01-01

    Studies of charged polymer chains are interesting in both fundamental and applied aspects. Especially, polyelectrolytes attract huge attention of researchers due to their ability to form interpolymer complexes with synthetic and biopolymers. The study was carried out on the fractions of hydrophilic copolymers of N-methyl-N-vinyl acetamide and N-methyl-N-vinyl amine hydrochloride of different degrees of polymerization and of different charge density using methods of molecular hydrodynamics. Hydrodynamic and conformational characteristics as well as molar masses of isolated molecules were estimated. In addition, the intrinsic viscosity of fractions was studied at the extreme ionic strengths - in distilled water (∼10 -6 M) and in 6M NaCl. Scaling relations for intrinsic viscosity, sedimentation and translational diffusion coefficients with molar mass were obtained. Conformational behavior of macromolecules with different linear charge density was compared. (paper)

  7. Load-release of small and macromolecules from elastomers with reversible gyroid mesoporosity

    DEFF Research Database (Denmark)

    Guo, Fengxiao; Schulte, Lars; Ndoni, Sokol

    2012-01-01

    . However, in the gel state in the presence of a good solvent the swollen matrix did show a nanoporous structure originated from the gyroid block copolymer precursor. Nanopores can be opened or closed depending on the presence or absence of a solvent. Macromolecules like PEG of different molecular weights......A collapsed elastomeric matrix of lightly cross-linked 1,2-polybutadiene (1,2-PB) was prepared from a self-assembled 1,2-polybutadiene-b- polydimethylsiloxane (1,2-PB-b-PDMS) of gyroid morphology after the removal of the PDMS block. No mesoporosity could be observed in the material in the dry state...... or small molecules like the surfactant SDS were loaded into the opened nanoporous matrix in the presence of a solvent and remained trapped. The loaded molecules could be released again in the presence of a solvent. The load and release of the molecules in deuterated form were monitored by in situ time...

  8. Synthesis and biological incorporatin of icons into macromolecules for NMR study

    International Nuclear Information System (INIS)

    Grant, D.M.

    1976-02-01

    Work has proceeded successfully to synthesize novel 13 C-labeled materials for incorporation into macromolecules. Gram quantities of C-4 labeled uracil have been synthesized and incorporated, by means of a mutant bacterial strain into t-RNA. The t-RNA has been isolated, purified, and carbon-13 T 1 studies have begun. A modern, well equipped biochemistry laboratory has become functional during the present contract period. Good progress has been made on nonenzymatic reactions of pyridoxal-5'-phosphate with selected amino actions. This effort has successfully elucidated many reaction intermediates and products. In addition, 13 C containing haptens have been synthesized and screening tests have now begun on rabbits to verify the specificity of antibodies for two haptens

  9. Sensitivity enhancement in NMR of macromolecules by application of optimal control theory

    International Nuclear Information System (INIS)

    Frueh, Dominique P.; Ito, Takuhiro; Li, J.-S.; Wagner, Gerhard; Glaser, Steffen J.; Khaneja, Navin

    2005-01-01

    NMR of macromolecules is limited by large transverse relaxation rates. In practice, this results in low efficiency of coherence transfer steps in multidimensional NMR experiments, leading to poor sensitivity and long acquisition times. The efficiency of coherence transfer can be maximized by design of relaxation optimized pulse sequences using tools from optimal control theory. In this paper, we demonstrate that this approach can be adopted for studies of large biological systems, such as the 800 kDa chaperone GroEL. For this system, the 1 H- 15 N coherence transfer module presented here yields an average sensitivity enhancement of 20-25% for cross-correlated relaxation induced polarization transfer (CRIPT) experiments

  10. Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems.

    Science.gov (United States)

    Bernkop-Schnürch, A; Kast, C E; Guggi, D

    2003-12-05

    Thiolated polymers (= thiomers) in combination with reduced glutathione (GSH) were shown to improve the uptake of hydrophilic macromolecules from the GI tract. The mechanism responsible for this permeation enhancing effect seems to be based on the thiol groups of the polymer. These groups inhibit protein tyrosine phosphatase, being involved in the closing process of tight junctions, via a GSH-mediated mechanism. The strong permeation enhancing effect of various thiomer/GSH systems such as poly(acrylic acid)-cysteine/GSH or chitosan-4-thio-butylamidine (chitosan-TBA)/GSH could be shown via permeation studies on freshly excised intestinal mucosa in Ussing-type chambers. Furthermore, the efficacy of the system was also shown in vivo. By utilizing poly(acrylic acid)-cysteine/GSH as carrier matrix, an absolute oral bioavailability for low molecular weight heparin of 19.9 +/- 9.3% and a pharmacological efficacy--calculated on the basis of the areas under the reduction in serum glucose levels of the oral formulation versus subcutaneous (s.c.) injection-for orally given insulin of 7% could be achieved. The incorporation of salmon calcitonin in chitosan-TBA/GSH led on the other hand to a pharmacological efficacy based on the areas under the reduction in plasma calcium levels of the oral thiomer formulation versus intravenous (i.v.) injection of 1.3%. Because of this high efficacy (i), the possibility to combine thiomer/GSH systems with additional low molecular weight permeation enhancers acting in other ways (ii) and minimal toxicological risks as these polymers are not absorbed from the GI tract (iii), thiolated polymers represent a promising novel tool for the oral administration of hydrophilic macromolecules.

  11. A mathematical model for filtration and macromolecule transport across capillary walls.

    Science.gov (United States)

    Facchini, L; Bellin, A; Toro, E F

    2014-07-01

    Metabolic substrates, such as oxygen and glucose, are rapidly delivered to the cells of large organisms through filtration across microvessels walls. Modelling this important process is complicated by the strong coupling between flow and transport equations, which are linked through the osmotic pressure induced by the colloidal plasma proteins. The microvessel wall is a composite media with the internal glycocalyx layer exerting a strong sieving effect on macromolecules, with respect to the external layer composed by the endothelial cells. The physiological structure of the microvessel is represented as the superimposition of two membranes with different properties; the inner membrane represents the glycocalyx, while the outer membrane represents the surrounding endothelial cells. Application of the mass conservation principle and thermodynamic considerations lead to a model composed of two coupled second-order ordinary differential equations for the hydrostatic and osmotic pressures, one, expressing volumetric mass conservation and the other, which is non-linear in the unknown osmotic pressure, expressing macromolecules mass conservation. Despite the complexity of the system, the assumption that the properties of the layers are piece-wise constant allows us to obtain analytical solutions for the two pressures. This solution is in agreement with experimental observations, which contrary to common belief, show that flow reversal cannot occur in steady-state conditions unless the hydrostatic pressure in the lumen drops below physiologically plausible values. The observed variations of the volumetric flux and the solute mass flux in case of a significant reduction of the hydrostatic pressure at the lumen are in qualitative agreement with observed variations during detailed experiments reported in the literature. On the other hand, homogenising the microvessel wall into a single-layer membrane with equivalent properties leads to a very different distribution of

  12. Exciton scattering approach for optical spectra calculations in branched conjugated macromolecules

    International Nuclear Information System (INIS)

    Li, Hao; Wu, Chao; Malinin, Sergey V.; Tretiak, Sergei; Chernyak, Vladimir Y.

    2016-01-01

    The exciton scattering (ES) technique is a multiscale approach based on the concept of a particle in a box and developed for efficient calculations of excited-state electronic structure and optical spectra in low-dimensional conjugated macromolecules. Within the ES method, electronic excitations in molecular structure are attributed to standing waves representing quantum quasi-particles (excitons), which reside on the graph whose edges and nodes stand for the molecular linear segments and vertices, respectively. Exciton propagation on the linear segments is characterized by the exciton dispersion, whereas exciton scattering at the branching centers is determined by the energy-dependent scattering matrices. Using these ES energetic parameters, the excitation energies are then found by solving a set of generalized “particle in a box” problems on the graph that represents the molecule. Similarly, unique energy-dependent ES dipolar parameters permit calculations of the corresponding oscillator strengths, thus, completing optical spectra modeling. Both the energetic and dipolar parameters can be extracted from quantum-chemical computations in small molecular fragments and tabulated in the ES library for further applications. Subsequently, spectroscopic modeling for any macrostructure within a considered molecular family could be performed with negligible numerical effort. We demonstrate the ES method application to molecular families of branched conjugated phenylacetylenes and ladder poly-para-phenylenes, as well as structures with electron donor and acceptor chemical substituents. Time-dependent density functional theory (TD-DFT) is used as a reference model for electronic structure. The ES calculations accurately reproduce the optical spectra compared to the reference quantum chemistry results, and make possible to predict spectra of complex macromolecules, where conventional electronic structure calculations are unfeasible.

  13. Exciton scattering approach for optical spectra calculations in branched conjugated macromolecules

    Science.gov (United States)

    Li, Hao; Wu, Chao; Malinin, Sergey V.; Tretiak, Sergei; Chernyak, Vladimir Y.

    2016-12-01

    The exciton scattering (ES) technique is a multiscale approach based on the concept of a particle in a box and developed for efficient calculations of excited-state electronic structure and optical spectra in low-dimensional conjugated macromolecules. Within the ES method, electronic excitations in molecular structure are attributed to standing waves representing quantum quasi-particles (excitons), which reside on the graph whose edges and nodes stand for the molecular linear segments and vertices, respectively. Exciton propagation on the linear segments is characterized by the exciton dispersion, whereas exciton scattering at the branching centers is determined by the energy-dependent scattering matrices. Using these ES energetic parameters, the excitation energies are then found by solving a set of generalized "particle in a box" problems on the graph that represents the molecule. Similarly, unique energy-dependent ES dipolar parameters permit calculations of the corresponding oscillator strengths, thus, completing optical spectra modeling. Both the energetic and dipolar parameters can be extracted from quantum-chemical computations in small molecular fragments and tabulated in the ES library for further applications. Subsequently, spectroscopic modeling for any macrostructure within a considered molecular family could be performed with negligible numerical effort. We demonstrate the ES method application to molecular families of branched conjugated phenylacetylenes and ladder poly-para-phenylenes, as well as structures with electron donor and acceptor chemical substituents. Time-dependent density functional theory (TD-DFT) is used as a reference model for electronic structure. The ES calculations accurately reproduce the optical spectra compared to the reference quantum chemistry results, and make possible to predict spectra of complex macromolecules, where conventional electronic structure calculations are unfeasible.

  14. Exciton scattering approach for optical spectra calculations in branched conjugated macromolecules

    Energy Technology Data Exchange (ETDEWEB)

    Li, Hao [Department of Chemistry, University of Houston, Houston, TX 77204 (United States); Wu, Chao [Electronic Structure Lab, Center of Microscopic Theory and Simulation, Frontier Institute of Science and Technology, Xian Jiaotong University, Xian 710054 (China); Malinin, Sergey V. [Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202 (United States); Tretiak, Sergei, E-mail: serg@lanl.gov [Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Center for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Chernyak, Vladimir Y., E-mail: chernyak@chem.wayne.edu [Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202 (United States)

    2016-12-20

    The exciton scattering (ES) technique is a multiscale approach based on the concept of a particle in a box and developed for efficient calculations of excited-state electronic structure and optical spectra in low-dimensional conjugated macromolecules. Within the ES method, electronic excitations in molecular structure are attributed to standing waves representing quantum quasi-particles (excitons), which reside on the graph whose edges and nodes stand for the molecular linear segments and vertices, respectively. Exciton propagation on the linear segments is characterized by the exciton dispersion, whereas exciton scattering at the branching centers is determined by the energy-dependent scattering matrices. Using these ES energetic parameters, the excitation energies are then found by solving a set of generalized “particle in a box” problems on the graph that represents the molecule. Similarly, unique energy-dependent ES dipolar parameters permit calculations of the corresponding oscillator strengths, thus, completing optical spectra modeling. Both the energetic and dipolar parameters can be extracted from quantum-chemical computations in small molecular fragments and tabulated in the ES library for further applications. Subsequently, spectroscopic modeling for any macrostructure within a considered molecular family could be performed with negligible numerical effort. We demonstrate the ES method application to molecular families of branched conjugated phenylacetylenes and ladder poly-para-phenylenes, as well as structures with electron donor and acceptor chemical substituents. Time-dependent density functional theory (TD-DFT) is used as a reference model for electronic structure. The ES calculations accurately reproduce the optical spectra compared to the reference quantum chemistry results, and make possible to predict spectra of complex macromolecules, where conventional electronic structure calculations are unfeasible.

  15. Spatial and temporal variations in bacterial macromolecule labeling with [methyl-3H]thymidine in a hypertrophic lake

    International Nuclear Information System (INIS)

    Robarts, R.D.; Wicks, R.J.; Sephton, L.M.

    1986-01-01

    The incorporation of [methyl- 3 H]thymidine into three macromolecular fractions, designated as DNA, RNA, and protein, by bacteria from Hartbeespoort Dam, South Africa, was measured over 1 year by acid-base hydrolysis procedures. Samples were collected at 10 m, which was at least 5 m beneath the euphotic zone. On four occasions, samples were concurrently collected at the surface. Approximately 80% of the label was incorporated into bacterial DNA in surface samples. At 10 m, total incorporation of label into bacterial macromolecules was correlated to bacterial utilization of glucose. The labeling of DNA, which ranged between 0 and 78% of total macromolecule incorporation, was inversely related to glucose uptake, total thymidine incorporation, and euphotic zone algal production. With decreased DNA labeling, increasing proportions of label were found in the RNA fraction and proteins. Enzymatic digestion followed by chromatographic separation of macromolecule fragments indicated that DNA and proteins were labeled while RNA was not. The RNA fraction may represent labeled lipids or other macromolecules or both. The data demonstrated a close coupling between phytoplankton production and heterotrophic bacterial activity in this hypertrophic lake but also confirmed the need for the routine extraction and purification of DNA during [methyl- 3 H]thymidine studies of aquatic bacterial production

  16. Novel tendencies in developing small-angle neutron scattering methods for studying the structure of biological macromolecules

    International Nuclear Information System (INIS)

    Serdyuk, I.

    1995-01-01

    In recent 20 years thermal neutron scattering has been acknowledged an important instrument for structural studies in molecular biology. The methods of neutron diffraction of high resolution, which are not discussed in this paper, have already permitted to obtain a detailed representation of the course of proteolytic reactions and have arisen a number of new problems connected with the localization of water molecules and the H-D exchange. The methods of low resolution widely used due to a relative simplicity of the experiment have been successfully applied for both solving structural problems per se and investigating the changes in the structure when macromolecules perform their biological functions. The most promising are novel experimental approaches: the triple isotopic substitution method and the method of spin dynamic polarization. These methods ensure solving structural problems at a higher resolution than the dimensions of the macromolecules studied. Installation of new experimental instruments makes neutron measurements more accessible, and development of direct methods for interpretation of experimental data using the apparatus of spherical harmonics opens new possibilities for small-angle neutron scattering making it a necessary element for interpretation of diffraction data of monocrystals of intricate biological macromolecules. The paper presents a brief account of the tendencies in theoretical development and practical use of small-angle scattering for studying biological macromolecules. Special attention is given to the studies carried out in the Laboratory of Neutron Physics on a unique pulse IBR-2 reactor. (author) 14 refs

  17. Hydroxycinnamic acids are ester-linked directly to glucosyl moieties within the lignan macromolecule from flaxseed hulls

    NARCIS (Netherlands)

    Struijs, K.; Vincken, J.P.; Verhoef, R.P.; Voragen, A.G.J.; Gruppen, H.

    2008-01-01

    In flaxseed hulls, lignans are present in an oligomeric structure. Secoisolariciresinol diglucoside (SDG), ester-linked to hydroxy-methyl-glutaric acid (HMGA), forms the backbone of this lignan macromolecule. The hydroxycinnamic acids p-coumaric acid glucoside (CouAG) and ferulic acid glucoside

  18. Conference on chemical evolution and the origin of life: Self-organization of the macromolecules of life

    International Nuclear Information System (INIS)

    1993-10-01

    The formation of biomolecules was a necessary step in the evolution of life on earth. This interdisciplinary conference emphasized the role of replication in processes of self-organization of biological macromolecules. The present document contains abstracts of the 26 contributions to the conference on chemical evolution. The individual contributions have been indexed separately for the database

  19. PRESS FREEDOM IN SINGAPORE AND MALAYSIA: DEFAMATION

    Directory of Open Access Journals (Sweden)

    Georgia Kate Chapman

    2015-04-01

    Full Text Available This paper focuses on the arguments around restriction on freedom of the press in the Strong States of Singapore and Malaysia. It assesses the presence of constraints on press freedoms in democratic western countries imposed by corporation rather than state and the similar effects that these constraints may have on bias present in publicly accessible news reporting. It argues that independence of the press does not just require protection from legal and executive regulation, but also protection from large media corporations and their political alignments. This report will assess the bias of reporting and news media publication that exists in Malaysia and Singapore due to legislative and regulatory constraints as opposed to bias that exist in the western liberal democratic nations of the United Kingdom (UK and the United States of America (USA due to Media Organisation control.

  20. CSR-communication in the Business Press

    DEFF Research Database (Denmark)

    Morsing, Mette; Langer, Roy

    on a broadly encompassing and ambiguous definition of CSR. Our empirical data shows how the business press in its discourse on CSR provides no clarity on the definition of CSR in terms of a coherent motive, a dominant stakeholder or a consistent issue, but rather maintains ambiguity and imprecision about......In this paper we analyze the construction of corporate social responsibility in the business press as an act of strategic ambiguity. While corporate social responsibility (CSR) generally evokes positive associations in public opinion, this paper demonstrates that these associations are based...... is systematically maintained in the business press. We refer to this process as strategic ambiguity. The paper discusses the potential value and limitations of framing CSR in a state of strategic ambiguity in the context of the concurrent rethinking of the role of business in modern welfare societies....

  1. Macromolecular competition titration method accessing thermodynamics of the unmodified macromolecule-ligand interactions through spectroscopic titrations of fluorescent analogs.

    Science.gov (United States)

    Bujalowski, Wlodzimierz; Jezewska, Maria J

    2011-01-01

    Analysis of thermodynamically rigorous binding isotherms provides fundamental information about the energetics of the ligand-macromolecule interactions and often an invaluable insight about the structure of the formed complexes. The Macromolecular Competition Titration (MCT) method enables one to quantitatively obtain interaction parameters of protein-nucleic acid interactions, which may not be available by other methods, particularly for the unmodified long polymer lattices and specific nucleic acid substrates, if the binding is not accompanied by adequate spectroscopic signal changes. The method can be applied using different fluorescent nucleic acids or fluorophores, although the etheno-derivatives of nucleic acid are especially suitable as they are relatively easy to prepare, have significant blue fluorescence, their excitation band lies far from the protein absorption spectrum, and the modification eliminates the possibility of base pairing with other nucleic acids. The MCT method is not limited to the specific size of the reference nucleic acid. Particularly, a simple analysis of the competition titration experiments is described in which the fluorescent, short fragment of nucleic acid, spanning the exact site-size of the protein-nucleic acid complex, and binding with only a 1:1 stoichiometry to the protein, is used as a reference macromolecule. Although the MCT method is predominantly discussed as applied to studying protein-nucleic acid interactions, it can generally be applied to any ligand-macromolecule system by monitoring the association reaction using the spectroscopic signal originating from the reference macromolecule in the presence of the competing macromolecule, whose interaction parameters with the ligand are to be determined. Copyright © 2011 Elsevier Inc. All rights reserved.

  2. Internet Marketing with WordPress

    CERN Document Server

    Mercer, David

    2011-01-01

    The book's accompanying Interactive learning environment on siteprebuilder.com gives you an online place to enhance and extend your practical experience through exercises, consolidate your learning and theoretical knowledge with marked quizzes, interaction with your WordPress marketing community, and fun and exciting extras such as challenges and competitions. This book is for people already using WordPress, who want more visitors, better visitors, and to convert more of them into paying customers. No prior marketing experience is required, although a basic understanding of either hosted or se

  3. WordPress 24-hour trainer

    CERN Document Server

    Plumley, George

    2015-01-01

    Create and expand feature-rich sites with no programming experience Ready to build, maintain, and expand your web site with WordPress but have no prior programming experience? WordPress 24-Hour Trainer, 3rd Edition is your book-and-video learning solution that walks you step-by-step through all the important features you will need to know. Lessons range from focused, practical everyday tasks to more advanced, creative features. Learn from an industry professional how to enter content, create pages, manage menus, utilize plug-ins, connect to social media, create membership and e-commerce site

  4. AUPress: A Comparison of an Open Access University Press with Traditional Presses

    Science.gov (United States)

    McGreal, Rory; Chen, Nian-Shing

    2011-01-01

    This study is a comparison of AUPress with three other traditional (non-open access) Canadian university presses. The analysis is based on the rankings that are correlated with book sales on Amazon.com and Amazon.ca. Statistical methods include the sampling of the sales ranking of randomly selected books from each press. The results of one-way…

  5. Bullying the media : Cultural and climato-economic readings of press repression versus press freedom

    NARCIS (Netherlands)

    Van de Vliert, E.

    Journalists and media assistants in many places are murdered, imprisoned, censored, threatened, and similarly harrassed. Here I document that, and explain why, there are three climato-economic niches of press repression versus press freedom as part of broader syndromes of national culture. A

  6. Change of Pressing Chamber Conicalness at Briquetting Process in Briquetting Machine Pressing Chamber

    Directory of Open Access Journals (Sweden)

    Peter Križan

    2012-01-01

    Full Text Available In this paper, we will present the impact of the conical shape of a pressing chamber, an important structural parameter. Besides the known impact of the technological parameters of pressing chambers, it is also very important to pay attention to their structural parameters. In the introduction, we present a theoretical analysis of pressing chamber conicalness. An experiment aimed at detecting this impact was performed at our institute, and it showed that increasing the conicalness of a pressing chamber improves the quality of the final briquettes. The conicalness of the pressing chamber has a significanteffect on the final briquette quality and on the construction of briquetting machines. The experimental findings presented here show the importance of this parameter in the briquetting process.

  7. 28 CFR 540.64 - Press pools.

    Science.gov (United States)

    2010-07-01

    ... Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT CONTACT WITH PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a... shall notify all news media representatives who have requested interviews or visits that have not been...

  8. Law of the Student Press. Second Edition.

    Science.gov (United States)

    Student Press Law Center, Washington, DC.

    Noting dramatic changes in First Amendment protections for high school students and new legal issues facing college newspaper editors, this book describes in detail the legal rights and responsibilities of both the high school and college press. While the book is extensively footnoted, it intentionally avoids "legal-ese" and "brings…

  9. Press kit kicks off new branding.

    Science.gov (United States)

    Rees, Tom

    2004-01-01

    A smartly produced press kit resulted in unprecedented news coverage when Denver's Porter Adventist Hospital recently unveiled plans for an extensive 80 million dollars redevelopment. A news conference was held to announce this plan, along with the opening of the hospital's new emergency department. The overall effort is part of the new branding strategy of the 75-year-old hospital.

  10. The Moral Universes of Libertarian Press Theory.

    Science.gov (United States)

    Wuliger, Gregory T.

    1991-01-01

    Uses Kantian logic to analyze the statement of Libertarian press theory "Truth beats falsehood in a free marketplace of ideas" as a definition, an observation, and a universal truth. Notes three corresponding moral universes, with differing ethical obligations. Discusses strengths and weaknesses of each. Cautions media ethics analysts…

  11. Investigation of pressing of molybdenum powder compacts

    International Nuclear Information System (INIS)

    Mymrin, S.A.; Kuznetsov, V.Eh.; Yampol'skij, M.L.; Leonov, S.A.; Mikhridinov, R.M.; Korzukhin, V.A.

    1990-01-01

    Results of an experimental investigation into pressing of compacts of MCh type molybdenum powders using the industrial equipment are presented. To measure the density of powder molybdenum billets a radioisotopic density meter with cesium-137 is used as radioactive gamma radiation source. The dependence of the produced billet density on the specific compacting pressure at different values of the powder bulk density is ascertained

  12. Eye-Pressing by Visually Impaired Children.

    Science.gov (United States)

    Jan, James E.; And Others

    1983-01-01

    The nature of eye-pressing as a visual stimulation mannerism in children with severely impaired eyesight is examined, and a possible physiological explanation (that self-stimulation occurs when the demand of the brain for meaningful visual information is not met) is offered. (CL)

  13. Spontaneous pneumomediastinum after bench press training.

    Science.gov (United States)

    Nishino, Tomoya

    2017-04-01

    Spontaneous pneumomediastinum is often associated with asthma and mainly affects adolescent males with a tall, thin body habitus. A 17-year-old man complained of chest and pharyngeal pain after bench press training and spontaneous pneumomediastinum was diagnosed. It should be considered in the differential diagnosis of chest pain of uncertain cause.

  14. A Journalist's Guide to the Free Press.

    Science.gov (United States)

    Ingelhart, Louis

    1996-01-01

    Summarizes the content of the federal constitution and various state constitutions regarding freedom of the press. Examines certain borderline issues, including actions and expressions, pornography, defamation, libel, and copyrighted material. States that regulation of unprotected material must be reasonable, specific, and clear. Discusses what…

  15. Free Press in a Constitutional Democracy

    Science.gov (United States)

    Lucianek, Christine

    2014-01-01

    This article describes a lesson in which students will examine several views expressed by the founders to understand the context for including freedom of the press in the First Amendment. Students will be asked to think about the role that the news media and the need to be an informed citizen continue to play in our democracy. Students will…

  16. [Report from the Student Press Law Center.

    Science.gov (United States)

    Student Press Law Center, Washington, DC.

    The Student Press Law Center serves as a national clearinghouse to collect, analyze, and distribute information on the First Amendment rights of student journalists and journalism teachers and on violations of these rights in high schools and colleges. This report details information concerning current censorship incidents: the investigation by…

  17. When International Press Rights "Are" the News

    Science.gov (United States)

    Freedman, Eric

    2006-01-01

    In many countries, reporters and editors face criminal prosecution, censorship, self-censorship, exile, tax audits, loss of broadcast and publication licenses, loss of jobs, assault, and even assassination based on how they practice their profession. Press rights and human rights advocacy groups try to draw media and official attention to those…

  18. Trial access to Cambridge University Press ebooks

    CERN Multimedia

    CERN Library

    2011-01-01

    From 1 August till 31 October, CERN users are invited to enjoy a trial access to all Cambridge University Press electronic books: http://ebooks.cambridge.org/. Please don't hesitate to send feedback to library.desk@cern.ch.

  19. A statistical model of macromolecules dynamics for Fluorescence Correlation Spectroscopy data analysis

    Directory of Open Access Journals (Sweden)

    Dmitri Koroliouk

    2016-08-01

    Full Text Available In this paper, we propose a new mathematical model to describe the mechanisms of biological macromolecules interactions. Our model consists of a discrete stationary random sequence given by a solution of difference stochastic equation, characterized by a drift predictive component and by a diffusion term. The relative statistical estimations are very simple and effective, promising to be a good tool for the mathematical description of collective biological reactions. This paper presents the mathematical model and its verification on a simulated data set, obtained on the basis of the well-known Stokes-Einsteinmodel. In particular, we considered several mix of particles of different diffusion coefficient, respectively: D1=10 mm2/sec and D2=100 mm2/sec. The parameters evaluated by this new mathematical model on simulated data show good estimation accuracy, in comparison with the prior parameters used in the simulations. Furthermore, when analyzing the data for the mix of particles with different diffusion coefficient, the proposed model parameters  (regression and  (square variance of the stochastic component have a good discriminative ability for the molar fraction determination.  In this paper, we propose a new mathematical model to describe the mechanisms of biological macromolecules interactions. Our model consists of a discrete stationary random sequence given by a solution of difference stochastic equation, characterized by a drift predictive component and by a diffusion term. The relative statistical estimations are very simple and effective, promising to be a good tool for mathematical description of collective biological reactions. This paper presents the mathematical model and its verification on simulated data set, obtained on the basis of the well-known Stokes-Einsteinmodel. In particular we considered several mix of particles of different diffusion coefficient, respectively: D1=10 mm2/sec and D2=100 mm2/sec. The parameters

  20. Is the macromolecule signal tissue-specific in healthy human brain? A (1)H MRS study at 7 Tesla in the occipital lobe.

    Science.gov (United States)

    Schaller, Benoît; Xin, Lijing; Gruetter, Rolf

    2014-10-01

    The macromolecule signal plays a key role in the precision and the accuracy of the metabolite quantification in short-TE (1) H MR spectroscopy. Macromolecules have been reported at 1.5 Tesla (T) to depend on the cerebral studied region and to be age specific. As metabolite concentrations vary locally, information about the profile of the macromolecule signal in different tissues may be of crucial importance. The aim of this study was to investigate, at 7T for healthy subjects, the neurochemical profile differences provided by macromolecule signal measured in two different tissues in the occipital lobe, predominantly composed of white matter tissue or of grey matter tissue. White matter-rich macromolecule signal was relatively lower than the gray matter-rich macromolecule signal from 1.5 to 1.8 ppm and from 2.3 to 2.5 ppm with mean difference over these regions of 7% and 12% (relative to the reference peak at 0.9 ppm), respectively. The neurochemical profiles, when using either of the two macromolecule signals, were similar for 11 reliably quantified metabolites (CRLB occipital lobe at 7T in healthy human brain. Copyright © 2013 Wiley Periodicals, Inc.

  1. Electrospun ECM macromolecules as biomimetic scaffold for regenerative medicine: challenges for preserving conformation and bioactivity

    Directory of Open Access Journals (Sweden)

    Chiara Emma Campiglio

    2017-05-01

    Full Text Available The extracellular matrix (ECM, the physiological scaffold for cells in vivo, provides structural support to cells and guaranties tissue integrity. At the same time, however, it represents an extremely complex and finely tuned signaling environment that contributes in regulating tissue homeostasis and repair. ECM can bind, release and activate signaling molecules and also modulate cell reaction to soluble factors. Cell-ECM interactions, as a result, are recognized to be critical for physiological wound healing, and consequently in guiding regeneration. Due to its complexity, mimicking ECM chemistry and architecture appears a straightforward strategy to exploit the benefits of a biologically recognizable and cell-instructive environment. As ECM consists primarily of sub-micrometric fibers, electrospinning, a simple and versatile technique, has attracted the majority efforts aimed at reprocessing of biologically occurring molecules. However, the ability to trigger specific cellular behavior is likely to depend on both the chemical and conformational properties of biological molecules. As a consequence, when ECM macromolecules are electrospun, investigating the effect of processing on their structure, and the extent to which their potential in directing cellular behavior is preserved, appears crucial. In this perspective, this review explores the electrospinning of ECM molecules specifically focusing on the effect of processing on polymer structure and on in vitro or in vivo experiments designed to confirm the maintenance of their instructive role.

  2. Needle-free delivery of macromolecules through the skin using controllable jet injectors.

    Science.gov (United States)

    Hogan, Nora C; Taberner, Andrew J; Jones, Lynette A; Hunter, Ian W

    2015-01-01

    Transdermal delivery of drugs has a number of advantages in comparison to other routes of administration. The mechanical properties of skin, however, impose a barrier to administration and so most compounds are administered using hypodermic needles and syringes. In order to overcome some of the issues associated with the use of needles, a variety of non-needle devices based on jet injection technology has been developed. Jet injection has been used primarily for vaccine administration but has also been used to deliver macromolecules such as hormones, monoclonal antibodies and nucleic acids. A critical component in the more recent success of jet injection technology has been the active control of pressure applied to the drug during the time course of injection. Jet injection systems that are electronically controllable and reversible offer significant advantages over conventional injection systems. These devices can consistently create the high pressures and jet speeds necessary to penetrate tissue and then transition smoothly to a lower jet speed for delivery of the remainder of the desired dose. It seems likely that in the future this work will result in smart drug delivery systems incorporated into personal medical devices and medical robots for in-home disease management and healthcare.

  3. Development of a Prototype System for Archiving Integrative/Hybrid Structure Models of Biological Macromolecules.

    Science.gov (United States)

    Vallat, Brinda; Webb, Benjamin; Westbrook, John D; Sali, Andrej; Berman, Helen M

    2018-04-09

    Essential processes in biology are carried out by large macromolecular assemblies, whose structures are often difficult to determine by traditional methods. Increasingly, researchers combine measured data and computed information from several complementary methods to obtain "hybrid" or "integrative" structural models of macromolecules and their assemblies. These integrative/hybrid (I/H) models are not archived in the PDB because of the absence of standard data representations and processing mechanisms. Here we present the development of data standards and a prototype system for archiving I/H models. The data standards provide the definitions required for representing I/H models that span multiple spatiotemporal scales and conformational states, as well as spatial restraints derived from different experimental techniques. Based on these data definitions, we have built a prototype system called PDB-Dev, which provides the infrastructure necessary to archive I/H structural models. PDB-Dev is now accepting structures and is open to the community for new submissions. Copyright © 2018 Elsevier Ltd. All rights reserved.

  4. Perspective: On the importance of hydrodynamic interactions in the subcellular dynamics of macromolecules

    Science.gov (United States)

    Skolnick, Jeffrey

    2016-09-01

    An outstanding challenge in computational biophysics is the simulation of a living cell at molecular detail. Over the past several years, using Stokesian dynamics, progress has been made in simulating coarse grained molecular models of the cytoplasm. Since macromolecules comprise 20%-40% of the volume of a cell, one would expect that steric interactions dominate macromolecular diffusion. However, the reduction in cellular diffusion rates relative to infinite dilution is due, roughly equally, to steric and hydrodynamic interactions, HI, with nonspecific attractive interactions likely playing rather a minor role. HI not only serve to slow down long time diffusion rates but also cause a considerable reduction in the magnitude of the short time diffusion coefficient relative to that at infinite dilution. More importantly, the long range contribution of the Rotne-Prager-Yamakawa diffusion tensor results in temporal and spatial correlations that persist up to microseconds and for intermolecular distances on the order of protein radii. While HI slow down the bimolecular association rate in the early stages of lipid bilayer formation, they accelerate the rate of large scale assembly of lipid aggregates. This is suggestive of an important role for HI in the self-assembly kinetics of large macromolecular complexes such as tubulin. Since HI are important, questions as to whether continuum models of HI are adequate as well as improved simulation methodologies that will make simulations of more complex cellular processes practical need to be addressed. Nevertheless, the stage is set for the molecular simulations of ever more complex subcellular processes.

  5. Insights into the key roles of epigenetics in matrix macromolecules-associated wound healing.

    Science.gov (United States)

    Piperigkou, Zoi; Götte, Martin; Theocharis, Achilleas D; Karamanos, Nikos K

    2017-10-24

    Extracellular matrix (ECM) is a dynamic network of macromolecules, playing a regulatory role in cell functions, tissue regeneration and remodeling. Wound healing is a tissue repair process necessary for the maintenance of the functionality of tissues and organs. This highly orchestrated process is divided into four temporally overlapping phases, including hemostasis, inflammation, proliferation and tissue remodeling. The dynamic interplay between ECM and resident cells exerts its critical role in many aspects of wound healing, including cell proliferation, migration, differentiation, survival, matrix degradation and biosynthesis. Several epigenetic regulatory factors, such as the endogenous non-coding microRNAs (miRNAs), are the drivers of the wound healing response. microRNAs have pivotal roles in regulating ECM composition during wound healing and dermal regeneration. Their expression is associated with the distinct phases of wound healing and they serve as target biomarkers and targets for systematic regulation of wound repair. In this article we critically present the importance of epigenetics with particular emphasis on miRNAs regulating ECM components (i.e. glycoproteins, proteoglycans and matrix proteases) that are key players in wound healing. The clinical relevance of miRNA targeting as well as the delivery strategies designed for clinical applications are also presented and discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Electric double layer and electrokinetic potential of pectic macromolecules in sugar beet

    Directory of Open Access Journals (Sweden)

    Kuljanin Tatjana A.

    2008-01-01

    Full Text Available Electrokinetic potential is an important property of colloidal particles and, regarding the fact that it is a well defined and easily measurable property, it is considered to be a permanent characteristic of a particular colloidal system. In fact, it is a measure of electrokinetic charge that surrounds the colloidal particle in a solution and is in direct proportion with the mobility of particles in an electric field. Gouy-Chapman-Stern-Graham's model of electric double layer was adopted and it was proven experimentally that the addition of Cu++ ions to sugar beet pectin caused a reduction in the negative electrokinetic potential proportional to the increase of Cu++ concentration. Higher Cu++ concentrations increased the proportion of cation specific adsorption (Cu++ and H+ with regard to electrostatic Coulombic forces. Consequently, there is a shift in the shear plane between the fixed and diffuse layers directed towards the diffuse layer, i.e. towards its compression and decrease in the electrokinetic potential or even charge inversion of pectin macromolecules.

  7. Synthesis of naturally-derived macromolecules through simplified electrochemically mediated ATRP

    Directory of Open Access Journals (Sweden)

    Paweł Chmielarz

    2017-11-01

    Full Text Available The flavonoid-based macroinitiator was received for the first time by the transesterification reaction of quercetin with 2-bromoisobutyryl bromide. In accordance with the “grafting from” strategy, a naturally-occurring star-like polymer with a polar 3,3',4',5,6-pentahydroxyflavone core and hydrophobic poly(tert-butyl acrylate (PtBA side arms was synthesized via a simplified electrochemically mediated ATRP (seATRP, utilizing only 78 ppm by weight (wt of a catalytic CuII complex. To demonstrate the possibility of temporal control, seATRP was carried out utilizing a multiple-step potential electrolysis. The rate of the polymerizations was well-controlled by applying optimal potential values during preparative electrolysis to prevent the possibility of intermolecular coupling of the growing polymer arms. This appears to be the first report using on-demand seATRP for the synthesis of QC-(PtBA-Br5 pseudo-star polymers. The naturally-derived macromolecules showed narrow MWDs (Đ = 1.08–1.11. 1H NMR spectral results confirm the formation of quercetin-based polymers. These new flavonoid-based polymer materials may find applications as antifouling coatings and drug delivery systems.

  8. Electronic method for autofluorography of macromolecules on two-d matrices

    International Nuclear Information System (INIS)

    Case, A.L.; Davidson, J.B.

    1983-01-01

    A method for detecting, localizing, and quantifying macromolecules contained in a two-dimensional matrix is provided which employs a television-based position sensitive detection system. A molecule-containing matrix may be produced by conventional means to produce spots of light at the molecule locations which are detected by the television system. The matrix , such as a gel matrix, is exposed to an electronic camera system including an image-intensifier and secondary electron conduction camera capable of light integrating times of many minutes. A light image stored in the form of a charge image on the camera tube target is scanned by conventional television techniques, digitized, and stored in a digital memory. Intensity of any point on the image may be determined from the number at the memory address of the point. The entire image may be displayed on a television monitor for inspection and photographing or individual spots may be analyzed through selected readout of the memory locations. Compared to conventional film exposure methods, the exposure time may be reduced 100-1000 times

  9. Identification of Characteristic Macromolecules of Escherichia coli Genotypes by Atomic Force Microscope Nanoscale Mechanical Mapping

    Science.gov (United States)

    Chang, Alice Chinghsuan; Liu, Bernard Haochih

    2018-02-01

    The categorization of microbial strains is conventionally based on the molecular method, and seldom are the morphological characteristics in the bacterial strains studied. In this research, we revealed the macromolecular structures of the bacterial surface via AFM mechanical mapping, whose resolution was not only determined by the nanoscale tip size but also the mechanical properties of the specimen. This technique enabled the nanoscale study of membranous structures of microbial strains with simple specimen preparation and flexible working environments, which overcame the multiple restrictions in electron microscopy and label-enable biochemical analytical methods. The characteristic macromolecules located among cellular surface were considered as surface layer proteins and were found to be specific to the Escherichia coli genotypes, from which the averaged molecular sizes were characterized with diameters ranging from 38 to 66 nm, and the molecular shapes were kidney-like or round. In conclusion, the surface macromolecular structures have unique characteristics that link to the E. coli genotype, which suggests that the genomic effects on cellular morphologies can be rapidly identified using AFM mechanical mapping. [Figure not available: see fulltext.

  10. New beamline dedicated to solution scattering from biological macromolecules at the ESRF

    International Nuclear Information System (INIS)

    Pernot, P; Theveneau, P; Giraud, T; Fernandes, R Nogueira; Nurizzo, D; Spruce, D; Surr, J; McSweeney, S; Round, A; Felisaz, F; Foedinger, L; Gobbo, A; Huet, J; Villard, C; Cipriani, F

    2010-01-01

    The new bio-SAXS beamline (ID14-3 at the ESRF, Grenoble, France) is dedicated exclusively to small-angle scattering experiments of biological macromolecules in solution and has been in user operation since November 2008. Originally a protein crystallography beamline, ID14-3 was refurbished, still as a part of the ESRF Structural Biology group, with the main aim to provide a facility with 'quick and easy' access to satisfy rapidly growing demands from crystallographers, biochemists and structural biologists. The beamline allows manual and automatic sample loading/unloading, data collection, processing (conversion of a 2D image to a normalized 1D X-ray scattering profile) and analysis. The users obtain on-line standard data concerning the size (radius of gyration, maximum dimension and volume) and molecular weight of samples which allow on-the fly ab-inito shape reconstruction in order to provide feedback enabling the data collection strategies to be optimized. Automation of sample loading is incorporated on the beamline using a device constructed in collaboration between the EMBL (Grenoble and Hamburg outstations) and the ESRF. Semi/automated data analysis is implemented following the model of the SAXS facility at X33, EMBL Hamburg. This paper describes the bio-SAXS beamline and set-up characteristics together with the examples of user data obtained.

  11. Antioxidant, antimicrobial, cell viability and enzymatic inhibitory of antioxidant polymers as biological macromolecules.

    Science.gov (United States)

    Hashemi Gahruie, Hadi; Niakousari, Mehrdad

    2017-11-01

    Polymeric antioxidants such as Catechinaldehyde Polycondensates, Catechin-acelaldehydepolycondensates, Flavonoid-grafted chitosan fibers, Ferulate hydrogel, Dextran ferulate hydrogel, Starch-quercetin conjugate, Gallic acid- and Caffeic acid-functionalized chitosan, Gallic acid - chitosan conjugate, Poly(rutin), Gallic acid grafted chitosan, Dextran-Catechin Conjugate belong to biological macromolecules. These kinds of compounds have stronger antioxidant potential and pharmacokinetic activities, as compared to similar low molecular weight preservatives. Most of these compounds sources are either antioxidants with low molecules polymerization, or polymers conjugation such as synthetic or natural preservatives. Additives are well known as being an important ingredient of food products due to their strong preservative potential. Many researchers and industries attempt to find synthesize materials with the same antioxidant potential and higher stability than the similar compounds with low molecular weight. Recently, macromolecular antioxidants have received wide attention as food additives and dietary supplements in functional foods. It seems that the main usage of these compounds is in the food packaging industry. Most of these compounds have strong antioxidant, antimicrobial, cell viability and enzymatic inhibitory properties. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Film Self-Assembly of Oppositely Charged Macromolecules Triggered by Electrochemistry through a Morphogenic Approach.

    Science.gov (United States)

    Dochter, Alexandre; Garnier, Tony; Pardieu, Elodie; Chau, Nguyet Trang Thanh; Maerten, Clément; Senger, Bernard; Schaaf, Pierre; Jierry, Loïc; Boulmedais, Fouzia

    2015-09-22

    The development of new surface functionalization methods that are easy to use, versatile, and allow local deposition represents a real scientific challenge. Overcoming this challenge, we present here a one-pot process that consists in self-assembling, by electrochemistry on an electrode, films made of oppositely charged macromolecules. This method relies on a charge-shifting polyanion, dimethylmaleic-modified poly(allylamine) (PAHd), that undergoes hydrolysis at acidic pH, leading to an overall switching of its charge. When a mixture of the two polyanions, PAHd and poly(styrenesulfonate) (PSS), is placed in contact with an electrode, where the pH is decreased locally by electrochemistry, the transformation of PAHd into a polycation (PAH) leads to the continuous self-assembly of a nanometric PAH/PSS film by electrostatic interactions. The pH decrease is obtained by the electrochemical oxidation of hydroquinone, which produces protons locally over nanometric distances. Using a negatively charged enzyme, alkaline phosphatase (AP), instead of PSS, this one-pot process allows the creation of enzymatically active films. Under mild conditions, self-assembled PAH/AP films have an enzymatic activity which is adjustable simply by controlling the self-assembly time. The selective functionalization of microelectrode arrays by PAH/AP was achieved, opening the route toward miniaturized biosensors.

  13. Graphic Arts: Book Three. The Press and Related Processes.

    Science.gov (United States)

    Farajollahi, Karim; And Others

    The third of a three-volume set of instructional materials for a graphic arts course, this manual consists of nine instructional units dealing with presses and related processes. Covered in the units are basic press fundamentals, offset press systems, offset press operating procedures, offset inks and dampening chemistry, preventive maintenance…

  14. Bench press exercise: the key points.

    Science.gov (United States)

    Padulo, J; Laffaye, G; Chaouachi, A; Chamari, K

    2015-06-01

    The bench press exercise (BPE) is receiving increasing interest as a field testing, training/therapeutic modality to improve neuromuscular performance or to increase bone mass density. Several studies have been performed using BPE as a standard for increasing upper-limb strength. For this purpose, the position of the bar, the loads, the sets, the number of repetitions, the recovery time in-between sets, the movement speed, the muscular work and the use of the determination of the one repetition maximum (1-RM) are the classical tools investigated in the literature that have been shown to affect the BPE effect on neuromuscular. The goal of the present short review is to make a picture of the current knowledge on the bench press exercise, which could be very helpful for a better understanding of this standard movement and its effects. Based on the related literature, several recommendations on these key points are presented here.

  15. Reducing VOC Press Emission from OSB Manufacturing

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Gary D. McGinnis; Laura S. WIlliams; Amy E. Monte; Jagdish Rughani: Brett A. Niemi; Thomas M. Flicker

    2001-12-31

    Current regulations require industry to meet air emission standards with regard to particulates, volatile organic compounds (VOCs), hazardous air pollutants (HAPs) and other gases. One of many industries that will be affected by the new regulations is the wood composites industry. This industry generates VOCs, HAPs, and particulates mainly during the drying and pressing of wood. Current air treatment technologies for the industry are expensive to install and operate. As regulations become more stringent, treatment technologies will need to become more efficient and cost effective. The overall objective of this study is to evaluate the use of process conditions and chemical additives to reduce VOC/HAPs in air emitted from presses and dryers during the production of oriented strand board.

  16. Method for hot pressing beryllium oxide articles

    Science.gov (United States)

    Ballard, Ambrose H.; Godfrey, Jr., Thomas G.; Mowery, Erb H.

    1988-01-01

    The hot pressing of beryllium oxide powder into high density compacts with little or no density gradients is achieved by employing a homogeneous blend of beryllium oxide powder with a lithium oxide sintering agent. The lithium oxide sintering agent is uniformly dispersed throughout the beryllium oxide powder by mixing lithium hydroxide in an aqueous solution with beryllium oxide powder. The lithium hydroxide is converted in situ to lithium carbonate by contacting or flooding the beryllium oxide-lithium hydroxide blend with a stream of carbon dioxide. The lithium carbonate is converted to lithium oxide while remaining fixed to the beryllium oxide particles during the hot pressing step to assure uniform density throughout the compact.

  17. Freedom of the Press – two concepts

    Directory of Open Access Journals (Sweden)

    Markus Meckl

    2015-03-01

    Full Text Available In 1644 the debate for freedom of expression started in modern times thanks to John Milton’s Areopagitica, where he still argued about God in order to justify his quest for freedom. With the enlightenment God lost his unifying role for society and could no longer serve as justification. Two arguments were brought then forward to justify freedom of the press: One by the continental movement of the enlightenment; the other from within the movement of utilitarianism, and most influentially by John Stuart Mill. Both underlined the importance of truth; however, they differed in their understanding on what truth was good for. This difference in their arguments had a lasting impact on the debate on the limits of freedom of the press.

  18. Applications of the quasi-elastic light scattering to the study of dynamic properties of charged macro-molecules

    International Nuclear Information System (INIS)

    Gouesin-Menez, Renee

    1979-01-01

    The object of this research thesis is to study the modifications of dynamic properties of a macromolecule under the influence of variations of its medium, by using a frequency analysis of the spectrum of light scattered by a solution of particles. Thus, an important part of this thesis addresses the study and development of the scattering method and of its analysis by 'photon pulses', and the development and adjustment of an electrophoretic device to study light scattering by molecules submitted to an electric field. Then, hydrodynamic characteristics of some macromolecules have been measured with or without electric field. The studied molecular systems have been: calibrated spheres of latex polystyrene, a globular protein (bovine serum albumin), a polysaccharide (under the form of a rigid short stick), a flexible linear polyelectrolyte (polymethacrylate), and two DNA samples

  19. Analysis of Institutional Press Releases and its Visibility in the Press

    Directory of Open Access Journals (Sweden)

    José Antonio Alcoceba-Hernando, Ph.D.

    2010-01-01

    Full Text Available The relationships between institutional communication and media communication influence the shaping of social representations of public issues. This research article analyses these relationships based on the case study of the external communication of a public institution, the press releases of Spain’s Youth Institute (Instituto de la Juventud, aka, Injuve, during three years and their repercussion in the press during the same period of time. The results obtained in this research allowed drawing conclusions on the types of communication production of the aforementioned institution and the news treatment of such pieces of information by the printed and digital media. The press releases and the news items were studied using quantitative media content analysis which focused, especially, in referential issues like the information treatment, the thematic analysis, youth representations in the case of the releases; and the visibility of the press releases in the making of news

  20. ACTIVATED HOT PRESSING BEHAVIOR OF WC NANOPOWDERS

    Directory of Open Access Journals (Sweden)

    Edwin GEVORKYAN

    2010-06-01

    Full Text Available The questions of consolidation of nanopowders concerning hot compaction by pressing activated by electric current action are considered. Mechanisms of grain boundary creep-sliding which are sequentially prevalent in a forming of compacted structures under influence of temperature factor and in the presence of a direct electric heating are discussed. Structural-transformational sources and conditions of forming of high physical-mechanical properties of nanopowder refractory solid-state products are described.

  1. The antimatter. Press breakfast 23 may 2000

    International Nuclear Information System (INIS)

    Spiro, M.; Dejardin, M.; Debu, P.; Aleksan, R.

    2000-05-01

    This document brings together the subjects discussed during the Press breakfast of 23 may 2000 on the antimatter, with scientists of the CEA and the CNRS. It presents the research programs and the experiments on the antimatter and the symmetry violation: the CP LEAR and the NA48 experiments at CERN, the BaBar detector at SLAC, the fundamental research at the CEA and the impacts on the energy policy. It provides also links for more detailed inquiries. (A.L.B.)

  2. Press conference of the 15 october 2002

    International Nuclear Information System (INIS)

    2002-10-01

    Facing the public hostile purposes of october 2002, concerning the renewable energies, Andre Antolini, President of the renewable energies syndicate, proposed a press conference to give information, data and realizations on the renewable energies. The text of the conference is presented, as data on employment, biofuels, the wind energy, the hydro-electricity the greenhouse effect fight, the public opinion, the solar heating, the photovoltaic and the future projects and electric power supply for 2010. (A.L.B.)

  3. Design of jigs, fixtures and press tools

    CERN Document Server

    Venkataraman, K

    2015-01-01

    Textbook presenting the fundamentals of tool design with special focus on jigs, fixtures and die design Covers sections on sheet metal forming processes; turning, grinding, broaching, welding and modular fixtures; principles of clamping; and an Introduction to Presses and Auxiliary Equipment Author has many years' experience in both academic and industrial environments, and presents this work in an easily-accessible style End of chapter questions and answers assist the learning process for both practicing tooling designers and engineers, and manufacturing en

  4. Natural cold pressed oils as cosmetic products

    Directory of Open Access Journals (Sweden)

    Małgorzata Ligęza

    2016-12-01

    Full Text Available Background. It seems that patients may ask general practitioners about natural cosmetics applied on the skin regarding their safety and suitability. Objectives. The aim of the study was to analyze natural cold pressed oils as potential cosmetic products. Material and methods. Cold pressed oils obtained from selected seeds and fruit stones were analyzed, including: chokeberry seed oil, blackcurrant seed oil, elderberry seed oil, raspberry seed oil, apricot seed oil, tomato seed oil, strawberry seed oil, broccoli seed oil, Nigella sativa seed oil, hemp oil, safflower seed oil, Silybum marianum seed oil and coconut oil. 80 adult volunteers assessed the cosmetic properties of the analyzed oils. Each of the volunteers tested 2 to 4 different oils, by applying them on the skin. In addition, patch tests with all analyzed oils were performed on 23 individuals. Results. The majority of tested oils were positively evaluated by the participants: in the opinion of the participants, oil extracted from safflower had the best appearance (100% positive opinions, coconut oil had the best smell (70% positive opinions, while black currant seed oil showed the best absorbency (85% positive opinions. No irritation was observed within the analyzed product group, albeit one allergic reaction to apricot seed oil was observed with patch testing. Conclusions . Based on the achieved results, it could be suggested that natural cold pressed oils can be applied to the skin as cosmetics. Our observations may be helpful for general practitioners when choosing natural cosmetics.

  5. Forming of AHSS using Servo-Presses

    Science.gov (United States)

    Groseclose, Adam Richard

    Stamping of Advanced High Strength Steel (AHSS) alloys poses several challenges due to the material's higher strength and low formability compared to conventional steels and other problems such as (a) inconsistency of incoming material properties, (b) ductile fracture during forming, (c) higher contact pressure and temperature rise during forming, (d) higher die wear leading to reduced tool life, (e) higher forming load/press capacity, and (f) large springback leading to dimensional inaccuracy in the formed part. [Palaniswamy et. al., 2007]. The use of AHSS has been increasing steadily in automotive stamping. New AHSS alloys (TRIP, TWIP) may replace some of the Hot Stamping applications. Stamping of AHSS alloys, especially higher strength materials, 780 MPa and higher, present new challenges in obtaining good part definition (corner and fillet radii), formability (fracture and resulting scrap) and in reducing springback. Servo-drive presses, having the capability to have infinitely variable and adjustable ram speed and dwell at BDC, offer a potential improvement in quality, part definition, and springback reduction especially when the infinitely adjustable slide motion is used in combination with a CNC hydraulic cushion. Thus, it is desirable to establish a scientific/engineering basis for improving the stamping conditions in forming AHSS using a servo-drive press.

  6. Steady-State Linear and Non-linear Optical Spectroscopy of Organic Chromophores and Bio-macromolecules.

    Science.gov (United States)

    Marazzi, Marco; Gattuso, Hugo; Monari, Antonio; Assfeld, Xavier

    2018-01-01

    Bio-macromolecules as DNA, lipid membranes and (poly)peptides are essential compounds at the core of biological systems. The development of techniques and methodologies for their characterization is therefore necessary and of utmost interest, even though difficulties can be experienced due to their intrinsic complex nature. Among these methods, spectroscopies, relying on optical properties are especially important to determine their macromolecular structures and behaviors, as well as the possible interactions and reactivity with external dyes-often drugs or pollutants-that can (photo)sensitize the bio-macromolecule leading to eventual chemical modifications, thus damages. In this review, we will focus on the theoretical simulation of electronic spectroscopies of bio-macromolecules, considering their secondary structure and including their interaction with different kind of (photo)sensitizers. Namely, absorption, emission and electronic circular dichroism (CD) spectra are calculated and compared with the available experimental data. Non-linear properties will be also taken into account by two-photon absorption, a highly promising technique (i) to enhance absorption in the red and infra-red windows and (ii) to enhance spatial resolution. Methodologically, the implications of using implicit and explicit solvent, coupled to quantum and thermal samplings of the phase space, will be addressed. Especially, hybrid quantum mechanics/molecular mechanics (QM/MM) methods are explored for a comparison with solely QM methods, in order to address the necessity to consider an accurate description of environmental effects on spectroscopic properties of biological systems.

  7. Rotational Diffusion of Macromolecules and Nanoparticles Modeled as Non-Overlapping Bead Arrays in an Effective Medium

    Directory of Open Access Journals (Sweden)

    Umar Twahir

    2011-05-01

    Full Text Available In this work, the retarding influence of a gel on the rotational motion of a macromolecule is investigated within the framework of the Effective Medium (EM model. This is an extension of an earlier study that considered the effect of a gel on the translational motion of a macromolecule [Allison, S. et al. J. Phys. Chem. B 2008, 112, 5858-5866]. The macromolecule is modeled as an array of non-overlapping spherical beads with no restriction placed on their size or configuration. Specific applications include the rotational motion of right circular cylinders and wormlike chains modeled as strings of identical touching beads. The procedure is then used to examine the electric birefringence decay of a 622 base pair DNA fragment in an agarose gel. At low gel concentration (M £ 0.010 gm/mL, good agreement between theory and experiment is achieved if the persistence length of DNA is taken to be 65 nm and the gel fiber radius of agarose is taken to be 2.5 nm. At higher gel concentrations, the EM model substantially underestimates the rotational relaxation time of DNA and this can be attributed to the onset of direct interactions that become significant when the effective particle size becomes comparable to the mean gel fiber spacing.

  8. Supramolecular Assembly of Comb-like Macromolecules Induced by Chemical Reactions that Modulate the Macromolecular Interactions In Situ.

    Science.gov (United States)

    Xia, Hongwei; Fu, Hailin; Zhang, Yanfeng; Shih, Kuo-Chih; Ren, Yuan; Anuganti, Murali; Nieh, Mu-Ping; Cheng, Jianjun; Lin, Yao

    2017-08-16

    Supramolecular polymerization or assembly of proteins or large macromolecular units by a homogeneous nucleation mechanism can be quite slow and require specific solution conditions. In nature, protein assembly is often regulated by molecules that modulate the electrostatic interactions of the protein subunits for various association strengths. The key to this regulation is the coupling of the assembly process with a reversible or irreversible chemical reaction that occurs within the constituent subunits. However, realizing this complex process by the rational design of synthetic molecules or macromolecules remains a challenge. Herein, we use a synthetic polypeptide-grafted comb macromolecule to demonstrate how the in situ modulation of interactions between the charged macromolecules affects their resulting supramolecular structures. The kinetics of structural formation was studied and can be described by a generalized model of nucleated polymerization containing secondary pathways. Basic thermodynamic analysis indicated the delicate role of the electrostatic interactions between the charged subunits in the reaction-induced assembly process. This approach may be applicable for assembling a variety of ionic soft matters that are amenable to chemical reactions in situ.

  9. Steady-State Linear and Non-linear Optical Spectroscopy of Organic Chromophores and Bio-macromolecules

    Directory of Open Access Journals (Sweden)

    Marco Marazzi

    2018-04-01

    Full Text Available Bio-macromolecules as DNA, lipid membranes and (polypeptides are essential compounds at the core of biological systems. The development of techniques and methodologies for their characterization is therefore necessary and of utmost interest, even though difficulties can be experienced due to their intrinsic complex nature. Among these methods, spectroscopies, relying on optical properties are especially important to determine their macromolecular structures and behaviors, as well as the possible interactions and reactivity with external dyes—often drugs or pollutants—that can (photosensitize the bio-macromolecule leading to eventual chemical modifications, thus damages. In this review, we will focus on the theoretical simulation of electronic spectroscopies of bio-macromolecules, considering their secondary structure and including their interaction with different kind of (photosensitizers. Namely, absorption, emission and electronic circular dichroism (CD spectra are calculated and compared with the available experimental data. Non-linear properties will be also taken into account by two-photon absorption, a highly promising technique (i to enhance absorption in the red and infra-red windows and (ii to enhance spatial resolution. Methodologically, the implications of using implicit and explicit solvent, coupled to quantum and thermal samplings of the phase space, will be addressed. Especially, hybrid quantum mechanics/molecular mechanics (QM/MM methods are explored for a comparison with solely QM methods, in order to address the necessity to consider an accurate description of environmental effects on spectroscopic properties of biological systems.

  10. Steady-State Linear and Non-linear Optical Spectroscopy of Organic Chromophores and Bio-macromolecules

    Science.gov (United States)

    Marazzi, Marco; Gattuso, Hugo; Monari, Antonio; Assfeld, Xavier

    2018-04-01

    Bio-macromolecules as DNA, lipid membranes and (poly)peptides are essential compounds at the core of biological systems. The development of techniques and methodologies for their characterization is therefore necessary and of utmost interest, even though difficulties can be experienced due to their intrinsic complex nature. Among these methods, spectroscopies, relying on optical properties are especially important to determine their macromolecular structures and behaviors, as well as the possible interactions and reactivity with external dyes – often drugs or pollutants – that can (photo)sensitize the bio-macromolecule leading to eventual chemical modifications, thus damages. In this review, we will focus on the theoretical simulation of electronic spectroscopies of bio-macromolecules, considering their secondary structure and including their interaction with different kind of (photo)sensitizers. Namely, absorption, emission and electronic circular dichroism (CD) spectra are calculated and compared with the available experimental data. Non-linear properties will be also taken into account by two-photon absorption, a highly promising technique (i) to enhance absorption in the red and infra-red windows and (ii) to enhance spatial resolution. Methodologically, the implications of using implicit and explicit solvent, coupled to quantum and thermal samplings of the phase space, will be addressed. Especially, hybrid quantum mechanics/ molecular mechanics (QM/MM) methods are explored for a comparison with solely QM methods, in order to address the necessity to consider an accurate description of environmental effects on spectroscopic properties of biological systems.

  11. The interstitial distribution of macromolecules in rat tumours is influenced by the negatively charged matrix components.

    Science.gov (United States)

    Wiig, Helge; Gyenge, Christina C; Tenstad, Olav

    2005-09-01

    Knowledge of macromolecular distribution volumes is essential in understanding fluid transport within normal and pathological tissues. In this study in vivo we determined the distribution volumes of several macromolecules, including one monoclonal antibody, in tumours and tested whether charges associated with the tumour extracellular matrix influence their available volumes. Steady state levels of the monoclonal antibody trastuzumab (Herceptin) (pI = 9.2), IgG (pI = 7.6) as well as native (pI = 5.0) and cationized albumin (pI = 7.6) were established in rats bearing dimethylbenzanthracene (DMBA)-induced mammary tumours by continuous infusion using osmotic minipumps. After a 5-7 day infusion period, the rats were nephrectomized and the extracellular volume was determined with 51Cr-labelled EDTA. Plasma volumes were measured with 125I-labelled human serum albumin or rat IgM in a separate series. Steady state concentrations of probes were determined in the interstitial fluid that was isolated by centrifugation from tumours or by post mortem wick implantation in the back skin. Calculations were made for interstitial fluid volume (Vi), along with the available (Va/Vi) and excluded (Ve/Vi) relative interstitial volume fractions. The Ve/Vi for the positively charged trastuzumab in tumours averaged 0.29 +/- 0.03 (n = 16), a value which was significantly lower than the corresponding one for IgG of 0.36 +/- 0.02 (n = 16). Native albumin was excluded from 38% of the tumour interstitial fluid, whereas cationization of albumin reduced the excluded volume by approximately 50%. Our experiments suggest that the tumour interstitium acts as a negatively charged matrix and is an important factor in determining the macromolecular distribution volume.

  12. A simple model for electrical charge in globular macromolecules and linear polyelectrolytes in solution

    Science.gov (United States)

    Krishnan, M.

    2017-05-01

    We present a model for calculating the net and effective electrical charge of globular macromolecules and linear polyelectrolytes such as proteins and DNA, given the concentration of monovalent salt and pH in solution. The calculation is based on a numerical solution of the non-linear Poisson-Boltzmann equation using a finite element discretized continuum approach. The model simultaneously addresses the phenomena of charge regulation and renormalization, both of which underpin the electrostatics of biomolecules in solution. We show that while charge regulation addresses the true electrical charge of a molecule arising from the acid-base equilibria of its ionizable groups, charge renormalization finds relevance in the context of a molecule's interaction with another charged entity. Writing this electrostatic interaction free energy in terms of a local electrical potential, we obtain an "interaction charge" for the molecule which we demonstrate agrees closely with the "effective charge" discussed in charge renormalization and counterion-condensation theories. The predictions of this model agree well with direct high-precision measurements of effective electrical charge of polyelectrolytes such as nucleic acids and disordered proteins in solution, without tunable parameters. Including the effective interior dielectric constant for compactly folded molecules as a tunable parameter, the model captures measurements of effective charge as well as published trends of pKa shifts in globular proteins. Our results suggest a straightforward general framework to model electrostatics in biomolecules in solution. In offering a platform that directly links theory and experiment, these calculations could foster a systematic understanding of the interrelationship between molecular 3D structure and conformation, electrical charge and electrostatic interactions in solution. The model could find particular relevance in situations where molecular crystal structures are not available or

  13. Permeation of macromolecules into the renal glomerular basement membrane and capture by the tubules

    Science.gov (United States)

    Lawrence, Marlon G.; Altenburg, Michael K.; Sanford, Ryan; Willett, Julian D.; Bleasdale, Benjamin; Ballou, Byron; Wilder, Jennifer; Li, Feng; Miner, Jeffrey H.; Berg, Ulla B.; Smithies, Oliver

    2017-01-01

    How the kidney prevents urinary excretion of plasma proteins continues to be debated. Here, using unfixed whole-mount mouse kidneys, we show that fluorescent-tagged proteins and neutral dextrans permeate into the glomerular basement membrane (GBM), in general agreement with Ogston's 1958 equation describing how permeation into gels is related to molecular size. Electron-microscopic analyses of kidneys fixed seconds to hours after injecting gold-tagged albumin, negatively charged gold nanoparticles, and stable oligoclusters of gold nanoparticles show that permeation into the lamina densa of the GBM is size-sensitive. Nanoparticles comparable in size with IgG dimers do not permeate into it. IgG monomer-sized particles permeate to some extent. Albumin-sized particles permeate extensively into the lamina densa. Particles traversing the lamina densa tend to accumulate upstream of the podocyte glycocalyx that spans the slit, but none are observed upstream of the slit diaphragm. At low concentrations, ovalbumin-sized nanoparticles reach the primary filtrate, are captured by proximal tubule cells, and are endocytosed. At higher concentrations, tubular capture is saturated, and they reach the urine. In mouse models of Pierson’s or Alport’s proteinuric syndromes resulting from defects in GBM structural proteins (laminin β2 or collagen α3 IV), the GBM is irregularly swollen, the lamina densa is absent, and permeation is increased. Our observations indicate that size-dependent permeation into the lamina densa of the GBM and the podocyte glycocalyx, together with saturable tubular capture, determines which macromolecules reach the urine without the need to invoke direct size selection by the slit diaphragm. PMID:28246329

  14. Conformation-independent structural comparison of macromolecules with ProSMART

    International Nuclear Information System (INIS)

    Nicholls, Robert A.; Fischer, Marcus; McNicholas, Stuart; Murshudov, Garib N.

    2014-01-01

    The Procrustes Structural Matching Alignment and Restraints Tool (ProSMART) has been developed to allow local comparative structural analyses independent of the global conformations and sequence homology of the compared macromolecules. This allows quick and intuitive visualization of the conservation of backbone and side-chain conformations, providing complementary information to existing methods. The identification and exploration of (dis)similarities between macromolecular structures can help to gain biological insight, for instance when visualizing or quantifying the response of a protein to ligand binding. Obtaining a residue alignment between compared structures is often a prerequisite for such comparative analysis. If the conformational change of the protein is dramatic, conventional alignment methods may struggle to provide an intuitive solution for straightforward analysis. To make such analyses more accessible, the Procrustes Structural Matching Alignment and Restraints Tool (ProSMART) has been developed, which achieves a conformation-independent structural alignment, as well as providing such additional functionalities as the generation of restraints for use in the refinement of macromolecular models. Sensible comparison of protein (or DNA/RNA) structures in the presence of conformational changes is achieved by enforcing neither chain nor domain rigidity. The visualization of results is facilitated by popular molecular-graphics software such as CCP4mg and PyMOL, providing intuitive feedback regarding structural conservation and subtle dissimilarities between close homologues that can otherwise be hard to identify. Automatically generated colour schemes corresponding to various residue-based scores are provided, which allow the assessment of the conservation of backbone and side-chain conformations relative to the local coordinate frame. Structural comparison tools such as ProSMART can help to break the complexity that accompanies the constantly growing

  15. Transport of macromolecules and particles at target sites for deposition of air pollutants

    International Nuclear Information System (INIS)

    Crocker, T.T.; Bhalla, D.K.

    1986-01-01

    This study analyzed rats' nasal, tracheal and bronchoalveolar epithelial permeability to macromolecules after they were exposed, in 2- or 4-hour periods of rest or exercise, to ozone (O3) (0.6, 0.8 or 2 ppm), nitrogen dioxide (NO2) (2.5, 6 or 12 ppm) or formaldehyde (10 ppm). Exercise was performed on a treadmill operated at a speed that led to a 2-fold increase in oxygen consumption. Histopathologic and electron microscopic cytochemical and autoradiographic studies were performed to identify the structural aspects of mucosal response. In rats not exposed to pollutants, the quantity of macromolecular tracers (99mTc-DTPA, 125I-BSA) in blood sampled 6, 7, 8, 9 and 10 minutes after a slow 5-minute instillation of comparable quantities of tracer molecules in the lumen of each zone, was lowest in nasal, highest in tracheal, and intermediate in the bronchoalveolar region. Exposure of resting rats to O3 did not affect nasal permeability, but tracheal and bronchoalveolar permeabilities increased by 2-fold 1 hour after the exposure. In rats exposed at rest to O3, tracheal permeability was no longer elevated 24 hours after exposure, but bronchoalveolar permeability remained elevated at 24 hours after exposure and was normal at 48 hours. Exposure during exercise increased the effect of O3 in the trachea and in the bronchoalveolar zone. However, exercise also prolonged the duration of the O3 effect on the tracheal zone from 1 hour to 24 hours and, in the bronchoalveolar zone, from 24 hours to 48 hours. Histologically, focal inflammatory lesions in the alveolar zone were maximal at 48 hours after a 4-hour resting exposure to O3. After exposure during exercise, the area of lung involved by lesions increased 4- to 7-fold above the lesion-bearing area in rats exposed while resting

  16. Conformation-independent structural comparison of macromolecules with ProSMART

    Energy Technology Data Exchange (ETDEWEB)

    Nicholls, Robert A., E-mail: nicholls@mrc-lmb.cam.ac.uk [MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH (United Kingdom); Fischer, Marcus [University of California San Francisco, San Francisco, CA 94158 (United States); McNicholas, Stuart [University of York, Heslington, York YO10 5DD (United Kingdom); Murshudov, Garib N. [MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH (United Kingdom)

    2014-09-01

    The Procrustes Structural Matching Alignment and Restraints Tool (ProSMART) has been developed to allow local comparative structural analyses independent of the global conformations and sequence homology of the compared macromolecules. This allows quick and intuitive visualization of the conservation of backbone and side-chain conformations, providing complementary information to existing methods. The identification and exploration of (dis)similarities between macromolecular structures can help to gain biological insight, for instance when visualizing or quantifying the response of a protein to ligand binding. Obtaining a residue alignment between compared structures is often a prerequisite for such comparative analysis. If the conformational change of the protein is dramatic, conventional alignment methods may struggle to provide an intuitive solution for straightforward analysis. To make such analyses more accessible, the Procrustes Structural Matching Alignment and Restraints Tool (ProSMART) has been developed, which achieves a conformation-independent structural alignment, as well as providing such additional functionalities as the generation of restraints for use in the refinement of macromolecular models. Sensible comparison of protein (or DNA/RNA) structures in the presence of conformational changes is achieved by enforcing neither chain nor domain rigidity. The visualization of results is facilitated by popular molecular-graphics software such as CCP4mg and PyMOL, providing intuitive feedback regarding structural conservation and subtle dissimilarities between close homologues that can otherwise be hard to identify. Automatically generated colour schemes corresponding to various residue-based scores are provided, which allow the assessment of the conservation of backbone and side-chain conformations relative to the local coordinate frame. Structural comparison tools such as ProSMART can help to break the complexity that accompanies the constantly growing

  17. Calculation of X-ray scattering curves and electron distance distribution functions of biological macromolecules in solution using the PROTEIN DATA BANK

    International Nuclear Information System (INIS)

    Mueller, J.J.; Friedrichowicz, E.; Nothnagel, A.; Wunderlich, T.; Ziehlsdorf, E.; Damaschun, G.

    1983-01-01

    The wide angle X-ray scattering curve, the electron distance distribution function and the solvent excluded volume of a macromolecule in solution are calculated from the atomic coordinates contained in the PROTEIN DATA BANK. The structures and the projections of the excluded volumes are depicted using molecule graphic routines. The described computer programs are used to determine the three-dimensional structure of macromolecules in solution from wide angle X-ray scattering data. (author)

  18. Tjekkoslovakisk presse år 2

    Directory of Open Access Journals (Sweden)

    Rudolf Prevratil

    1991-09-01

    Full Text Available Danske teleselskaber overvejer at etablere sig som kabeloperatører i Polen, mens et amerikansk selskab allerede er igang i Warszawa og Krakow. Franske lokalradionetworks opretter filialer i Polen og Tjekko- slovakiet. Den tjekkiske statsradio stiller sendenet til rådighed for Radio Free Europe. Springer-koncernen opretter en "østtysk" pendant til Bild, hvis redaktionelle hovedlinje lægger sig op ad de dybe sociale frustrati- oner, der fulgte med DDR's indlemmelse i BDR. Maxwell, Hersant og Berlusconi m.fl. etablerer sig alene eller med lokale konstellationer inden for trykt presse i flere øst- og mellemeuropæiske stater. Samtidig for- søger den tidligere undergrundspresse at vinde økonomisk og politisk fodfæste inden for markedets og "det legale samfunds" rammer, i kon- kurrence med fortidens mediemutanter og vestlige mediekoncerner. Rudolf Prevratils artikel er en refleksion over en del af de problemer, primært af økonomisk og politisk art, som har tårnet sig op for den tjek- koslovakiske presse efter fløjlsrevolutionen i november 1989. Den giver et billede af dagens situation og får gennem sine analyser påvist, at etab- lingen af en demokratisk presse i Tjekkoslovakiet ikke alene er afhængig af "hjælp udefra", men i nok så høj grad forudsætter et net af sociale og kulturelle udviklingsprocesser, som både anerkender opgøret med for- tiden og vedkender sig den historiske arv. Artiklen er oversat fra engelsk af Per Jauert.

  19. Press Freedom on the Media Agenda

    OpenAIRE

    Pires, Terezinha Maria de Carvalho Cruz

    2007-01-01

    This article proposes to present a refl ection on the meanings constructed by the Brazilian written press regarding media and democracy. For this, it was necessary to recompose a specifi c journalistic event: the submission to the Brazilian Congress of a bill to create the Federal Journalism Council by the Brazilian President, Luiz Inácio Lula da Silva, at the request of the National Journalists Federation in August, 2004. This procedure gave rise to something rarely seen: the media were in the...

  20. Pocketbook of the economic press 1994

    International Nuclear Information System (INIS)

    Kroll, J.M.

    1994-01-01

    The present 34th edition of this pocketbook gives an overview of German economic journalists with their specific branches, important specialist newspaper editorial boards, the economic editors of the daily-, weekly- and public press, radio and television broadcusting stations as well as news-, information- and teletext services. In addition, 1600 public relations offices of industrial businesses, industry and trade chambers and universities are given. It concludes with information on authorities at a national and county level and more than 1200 business groups and leading bodies. (BWI) [de

  1. WordPress all-in-one for dummies

    CERN Document Server

    Sabin-Wilson, Lisa

    2013-01-01

    Top WordPress guide, now fully updated for the latest WordPress release! This updated new edition comprises one of the largest collections of practical intermediate to advanced information on WordPress. Fully updated for the latest WordPress release, this in-depth book covers it all, from setting up your software to publishing your site, using SEO and social media, developing and using plug-ins, running multiple sites with WordPress, and more. Veteran author Lisa Sabin-Wilson is a top authority on WordPress, and she and her co-authors pack this book with essential and easy-to-follo

  2. Effect of hot pressing additives on the leachability of hot pressed sodium hydrous titanium oxide

    International Nuclear Information System (INIS)

    Valentine, T.M.; Sambell, R.A.J.

    1980-01-01

    Sodium hydrous titanium oxide is an ion exchange resin which can be used for immobilizing medium level waste (MLW) liquors. When hot pressed, it undergoes conversion to a ceramic. Three low melting point materials (borax, bismuth trioxide, and a mixture of PbO/CuO) were added to the (Na)HTiO and the effect that each of these had on aiding densification was assessed. Hot pressing temperature, applied pressure, and percentage addition of hot pressing aid were varied. Percentage open porosity, flexural strength, and leachability were measured. There was a linear relationship between the percentage open porosity and the logarithm of the leach rate for a constant percentage addition of each additive

  3. The press media and the risk perception

    International Nuclear Information System (INIS)

    Manetti, Cristiane Teixeira

    2009-01-01

    In this study it was identified the frequency of negative and positive news on the nuclear question in the press media. Due to the complexity of the matter, we opt to perform a study case that could illustrate the theoretical discussion presented in this research. Thus, due to the constant presence of news related to IPCC meeting, in the national and foreign press, we opt to focus our study on one year period just after the release of the 4th IPCC Report, in February of 2007. The research was centered only in the printed matters, since there is significant differences between the printed media and others, like TV, radio or web, restricting the use of the same bibliographical reference. In this study it was collected journalistic material involving the nuclear energy and was verified the predominant speech of the vehicles of communication and the sources of information. It was noted the predominance of positive articles, mainly due to the weight of the favorable speeches by authorities, cited as the most frequent in the paper. The negative approach almost always was assumed by the ONGs in general, as expected, due to the its well known position in the treatment of matters related to the nuclear energy. Also it is important to point out that all the tracked vehicles of information mixed positive and negative news articles on the subject; and evidences of hegemonic speech by official sources had been observed. (author)

  4. A CONCEPTUAL APPROACH ON PRESS CONFERENCE

    Directory of Open Access Journals (Sweden)

    Ioana Olariu

    2015-07-01

    Full Text Available A press conference is an important tool of public relations. The primary role of public relations is to manage a company’s reputation and help build public consent for its enterprises. The goal of PR is to develop and maintain goodwill with most, if not all, of its publics. Failure to do so may mean loss of customers and revenues, time lost dealing with complaints or lawsuits, and loss of esteem. A company’s publics change constantly. Well-executed public relations is an ongoing process that molds good long-term relationships and plays an important role in relationship marketing and integrated communications. Companies often call press conference when they have significant news to announce, such as the introduction of a new product or advertising campaign. Although used less often by organizations and corporations, this form of delivery can be very effective. The topic must be of major interest to a specific group before it is likely to gain coverage.

  5. Press Conference: LHC Restart, Season 2

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    PRESS BRIEFING ON THE LARGE HADRON COLLIDER (LHC) RE-START, SEASON 2 AT CERN, GLOBE OF SCIENCE AND INNOVATION Where :   http://cern.ch/directions   at the Globe of Science and Innovation When : Thursday, 12 March from 2.30 to 3.30pm - Open seating as from 2.15pm Speakers : CERN’s Director General, Rolf Heuer and Director of Accelerators, Frédérick Bordry, and representatives of the LHC experiments Webcast : https://webcast.web.cern.ch/webcast/ Dear Journalists, CERN is pleased to invite you to the above press briefing which will take place on Thursday 12 March, in the Globe of Science and Innovation, 1st floor, from 2.30 to 3.30pm. The Large Hadron Collider (LHC) is ready to start up for its second three-year run. The 27km LHC is the largest and most powerful particle accelerator in the world operating at a temperature of -217 degrees Centigrade and powered to a current of 11,000 amps. Run 2 of the LHC follows a two-year technical s...

  6. Multi-Functional pi-Conjugated Macromolecules Based on Poly(Phenylene Vinylene)

    Science.gov (United States)

    1994-03-14

    methacrylate-co-4-vinylpyridine)" (in press). 43. J . Polym. Sci., (with R. Vukovic , G. Bogdanic, V. Kuresevic, M. Tomaskovic and W.J. MacKnight) "Phase...Sokolik I Dr. Zhou Yang Dr. Iwao Teraoka IV. JUNIOR RESEARCH PERSONNEL: J . Neill B. Ma. S.L I U i I I i 5 VI. ABSTRACT OF ACCOMPLISHMENTS This report is...chains. I I U I * 14 I VIII. PUBLICATIONS IN PERIOD WITH AFOSR SUPPORT 1. J . Chem. Phys. 98, 712-716 (1993) (with G. Mao, J.E. Fischer and M.J. Winokur

  7. FUNCTION OF PHLOEM-BORNE INFORMATION MACROMOLECULES IN INTEGRATING PLANT GROWTH & DEVELOPMENT

    Energy Technology Data Exchange (ETDEWEB)

    William J. Lucas

    2012-11-12

    Studies on higher plants have revealed the operation of cell-to-cell and long-distance communication networks that mediate the transport of information macromolecules, such as proteins and RNA. Based on the findings from this DOE-funded project and results from other groups, it is now well established that the enucleate sieve tube system of the angiosperms contains a complex set of proteins including RNA binding proteins as well as a unique population of RNA molecules, comprised of both mRNA and small RNA species. Hetero-grafting experiments demonstrated that delivery of such RNA molecules, into the scion, is highly correlated with changes in developmental phenotypes. Furthermore, over the course of this project, our studies showed that plasmodesmata and the phloem are intimately involved in the local and systemic spread of sequence-specific signals that underlie gene silencing in plants. Major advances were also made in elucidating the underlying mechanisms that operate to mediate the selective entry and exit of proteins and RNA into and out of the phloem translocation stream. Our pioneering studies identified the first plant protein with the capacity to both bind specifically to small RNA molecules (si-RNA) and mediate in the cell-to-cell movement of such siRNA. Importantly, studies conducted with support from this DOE program also yielded a detailed characterization of the first phloem-mobile RNP complex isolated from pumpkin, namely the CmRBP50-RNP complex. This RNP complex was shown to bind, in a sequence-specific manner, to a set of transcripts encoding for transcription factors. The remarkable stability of this CmRBP50-RNP complex allows for long-distance delivery of bound transcripts from mature leaves into developing tissues and organs. Knowledge gained from this project can be used to exert control over the long-distance signaling networks used by plants to integrate their physiological and developmental programs at a whole plant level. Eventually, this

  8. Investigation of the optical properties of novel organic macromolecules for solar cell applications

    Science.gov (United States)

    Adegoke, Oluwasegun Oluwasina

    The search for renewable energy sources to replace fossil fuel has been a major research focus in the energy sector. The sun, with its vast amount of energy, remains the most abundant and ubiquitous energy source that far exceeds the world energy demand. The ability to effectively capture and convert energy from the sun in the form of photons will be the key to its effective utilization. Organic macromolecules have tremendous potentials to replace and out-perform existing materials, due to their low-cost, ease of tunability, high absorption coefficient and "green" nature. In this dissertation, spectroscopic techniques of steady state absorption and time-resolved fluorescence spectroscopy were used to show the improved absorption of the oligothiophene-functionalized ZnPc through ultrafast energy transfer. ZnPc is known for its chemical and thermal stability. The power conversion efficiency (PCE) in ZnPc-based solar devices is however, very low because of the poor absorption of ZnPc in the 300 - 550 nm region of the solar spectrum. Oligothiophenes have good absorption in the spectral region where the absorption of ZnPc is poor. Other groups of organic compounds that have gained prominence in the study for the design of efficient active materials for photovoltaic cells are the polymers. In the dissertation, different factors which can affect the performance of organic polymers in photovoltaics systems were investigated and analyzed. The effects of the alteration of conjugation, donor-acceptor groups, heteroatoms and alkyl side chains on the photophysical properties and ultimately the performance of organic polymers in organic photovoltaics were investigated. The different effects were investigated using ultrafast spectroscopic techniques which are capable of providing insight of fluorescence decay dynamics at very short times in a time scale of femtosecond. The electronic structure calculations of the polymers were carried out to provide further evidence to the

  9. Stellate macroporous silica nanospheres in bio-macromolecules encapsulation and delivery

    Science.gov (United States)

    Chi, Hao-Hsin

    This project focused on using mesoporous silica as a solid support to encapsulate enzymes for operating a highly economic, and recyclable biomass processing system. The main objective is to turn non-food biomass sources into food products. Enzymes are macromolecules with the structural backbone of proteins or ribonucleic acid sequences (RNAs) which work as catalysts in living organisms. Enzymes have the advantage of being the least contaminating catalyst due to normal catalyst might generate toxic by-product, and preferable to organic and inorganic catalysts, especially when used for product related to human used, which require biocompatibility of final product. However, there are several disadvantages in enzyme utilization. Their fabrication is time-consuming and requires elaborated molecular biology processes. Most of the enzymes need well-defined reaction conditions to be functional and operate at high yield. Unfortunately, although they are reusable as normal catalysts, it proves difficult to extract or reuse the enzymes from a reaction. Also, enzyme molecules are easily degradable and demand proper storage. To overcome some of the disadvantages, especially regarding stability to degradation, recovery, and reusability, immobilization of enzyme on solid support has become a thriving methodology. In recent years, mesoporous silica nanomaterials(MSN) have been at the forefront of enzyme immobilization given their extensive surface area, which provides capability to increase enzyme loading and for their demonstrate ability to protect enzyme from degradation, thus enabling high recyclability. Mesoporous silica is biocompatible and has already been used for several applications included. Catalysis, drug delivery, and Bio-imaging. Previously published research utilized mesoporous silica to deliver drugs, DNAs, RNAs or encapsulate single enzyme. The objective of this research is completed to develop a new porous silica platform that is unique in its porosity structure

  10. Searching for a Free Press in Indian Country.

    Science.gov (United States)

    Benton, Sherrole

    1994-01-01

    Describes the tribally controlled media's efforts to provide a form of checks and balances against the tribal council on behalf of the tribal community. Examines the issue of freedom of the tribal press, suggesting that tribal council's control of press's operating funds may limit press freedom. (MAB)

  11. STS-114: Discovery Launch Readiness Press Conference

    Science.gov (United States)

    2005-01-01

    Michael Griffin, NASA Administrator; Wayne Hale, Space Shuttle Deputy Program Manager; Mike Wetmore, Director of Shuttle Processing; and 1st Lieutenant Mindy Chavez, Launch Weather Officer-United States Air Force 45th Weather Squadron are in attendance for this STS-114 Discovery launch readiness press conference. The discussion begins with Wayne Hale bringing to the table a low level sensor device for everyone to view. He talks in detail about all of the extensive tests that were performed on these sensors and the completion of these ambient tests. Chavez presents her weather forecast for the launch day of July 26th 2005. Michael Griffin and Wayne Hale answer questions from the news media pertaining to the sensors and launch readiness. The video ends with footage of Pilot Jim Kelly and Commander Eileen Collins conducting test flights in a Shuttle Training Aircraft (STA) that simulates Space Shuttle landing.

  12. Effect of vitamin A deficiency on permeability of the small intestinal mucosa for macromolecules in adult rats

    International Nuclear Information System (INIS)

    Gmoshinskii, I.V.; Khvylya, S.I.; Kon', I.Ya.

    1987-01-01

    The authors study the effect of experimental vitamin A deficiency on absorption of macromolecules of hen's ovalbumin in the intestine. An electron-microscopic study of permeability of small intestine enterocytes for particles of colloidal lanthanum hydroxide La(OH) 3 was carried out at the same time. The concentration of unsplit hen's ovalbumin in the blood of the rats used in the experiment was determined by competitive radioimmunoassay. Samples of serum were incubated with indicator doses of 125 I-OA. Radioactivity of the precipitates was measured

  13. Idealized Compression Ratio for a Screw Briquetting Press

    Directory of Open Access Journals (Sweden)

    Peter Biath

    2012-01-01

    Full Text Available This paper deals with issues in determining the ideal compression ratio for a screw briquetting press. First, the principles of operation and a basic description of the main parts of a screw briquetting press are introduced. The next section describes the pressing space by means of 3D software. The pressing space was created using a Boolean subtract function. The final section of the paper measures the partial volumes of the pressing chamber in CATIA V5 by function of measuring. The measured values are substituted into the formula for the compression ratio, and the resulting evaluations are presented in the diagram in the conclusion of this paper.

  14. Properties of hot pressed MgB2/Ti tapes

    International Nuclear Information System (INIS)

    Kovac, P.; Husek, I.; Melisek, T.; Fedor, J.; Cambel, V.; Morawski, A.; Kario, A.

    2009-01-01

    Hot axial and hot isostatic pressing was applied for single-core MgB 2 /Ti tapes. Differences in transport current density, n-exponents and critical current anisotropy are discussed and related to the grain connectivity influenced by pressing. The magnetic Hall probe scanning measurements allowed observing the isolated regions for axially hot pressed sample attributed to the longitudinally oriented cracks introduced by pressing. The highest current densities were measured for the tape subjected to hot isostatic pressing due to improved connectivity.

  15. Macromolecule simulation and CH{sub 4} adsorption mechanism of coal vitrinite

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Song, E-mail: songyu10094488@126.com [School of Resources and Earth Science, China University of Mining & Technology, Xuzhou 221116 (China); Key Laboratory of Coal bed Methane Resource & Reservoir Formation Process, Ministry of Education, Xuzhou 221008 (China); Yan-ming, Zhu; Wu, Li [School of Resources and Earth Science, China University of Mining & Technology, Xuzhou 221116 (China); Key Laboratory of Coal bed Methane Resource & Reservoir Formation Process, Ministry of Education, Xuzhou 221008 (China)

    2017-02-28

    Highlights: • Molecular model of single maceral vitrinite was obtained by {sup 13}C NMR, FT IR and HRTEM. • An optimal configuration was obtained through calculation of MM and MD. • The adsorption parameters for methane and vitrinite were determined with DFT and GCMC. - Abstract: The microscopic mechanism of interactions between CH{sub 4} and coal macromolecules is of significant practical and theoretical importance in CBM development and methane storage. Under periodic boundary conditions, the optimal energy configuration of coal vitrinite, which has a higher torsion degree and tighter arrangement, can be determined by the calculation of molecular mechanics (MM) and molecular dynamics (MD), and annealing kinetics simulation based on ultimate analysis, {sup 13}C NMR, FT IR and HRTEM. Macromolecular stabilization is primarily due to the van der Waals energy and covalent bond energy, mainly consisting of bond torsion energy and bond angle energy. Using the optimal configuration as the adsorbent, GCMC simulation of vitrinite adsorption of CH{sub 4} is conducted. A saturated state is reached after absorbing 17 CH{sub 4}s per coal vitrinite molecule. CH{sub 4} is preferentially adsorbed on the edge, and inclined to gathering around the branched chains of the inner vitrinite sites. Finally, the adsorption parameters are calculated through first principle DFT. The adsorbability order is as follows: aromatic structure> heteroatom rings > oxygen functional groups. The adsorption energy order is as follows: Top < Bond < Center, Up < Down. The order of average RDF better reflects the adsorption ability and that of [-COOH] is lower than those of [−C=O] and [C−O−C]. CH{sub 4} distributed in the distance of 0.99–16 Å to functional groups in the type of monolayer adsorption and the average distance order manifest as [−C=O] (1.64 Å) < [C−O−C] (1.89 Å) < [−COOH] (3.78 Å) < [-CH{sub 3}] (4.11 Å) according to the average RDF curves. CH{sub 4} enriches

  16. Detection of site-specific binding and co-binding of ligands to macromolecules using 19F NMR

    International Nuclear Information System (INIS)

    Jenkins, B.G.

    1991-01-01

    Study of ligand-macromolecular interactions by 19 F nuclear magnetic resonance (NMR) spectroscopy affords many opportunities for obtaining molecular biochemical and pharmaceutical information. This is due to the absence of a background fluorine signal, as well as the relatively high sensitivity of 19 F NMR. Use of fluorine-labeled ligands enables one to probe not only binding and co-binding phenomena to macromolecules, but also can provide data on binding constants, stoichiometries, kinetics, and conformational properties of these complexes. Under conditions of slow exchange and macromolecule-induced chemical shifts, multiple 19 F NMR resonances can be observed for free and bound ligands. These shifted resonances are a direct correlate of the concentration of ligand bound in a specific state rather than the global concentrations of bound or free ligand which are usually determined using other techniques such as absorption spectroscopy or equilibrium dialysis. Examples of these interactions are demonstrated both from the literature and from interactions of 5-fluorotryptophan, 5-fluorosalicylic acid, flurbiprofen, and sulindac sulfide with human serum albumin. Other applications of 19 F NMR to study of these interactions in vivo, as well for receptor binding and metabolic tracing of fluorinated drugs and proteins are discussed

  17. Synthesis and evaluation of macromolecule-bound derivatives of a peptidyl-1-beta-D-arabinofuranosylcytosine prodrug.

    Science.gov (United States)

    Balajthy, Zoltan

    2008-04-01

    Macromolecule-bound Val-Leu-Lys-ara-C (1) prodrugs were synthesized with spacers (-HN-(CH(2))(x)-CO-; x =1,3,5) between the dextran carrier (T-70) and 1, in order to achieve a sustained-release drug delivery system dextran-NH-(CH(2))(x:1,3,5)-CO-Val-Leu-Lys-ara-C (5, 6 and 7). The conjugation increased the stability of 1 in aqueous buffer solutions by three times (t((1/2)) 53.0 h, pH 7.4). The length of spacer also regulated the rate of hydrolysis of the prodrugs in serum. The shortest spacer (-HN-(CH(2))-CO-, (2)) in 5 provided the best protection of 1 against the hydrolyzing ability of proteinase- alpha(2)-macroglobulin complexes, increasing its half-life approximately 30-fold. The conjugation procedure resulted in a growth arrest ability for macromolecular-bound prodrugs 5, 6 and 7 against L1210 with IC(50) of 0.01 microM in vitro, which is significantly lower than that of other ara-C-macromolecule conjugates. 5 and 6 arrested cell growth in a broader range of concentration, between 1 x 10(-5)-1.0 microM, than ara-C could.

  18. Microvillus-Specific Protein Tyrosine Phosphatase SAP-1 Plays a Role in Regulating the Intestinal Paracellular Transport of Macromolecules.

    Science.gov (United States)

    Mori, Shingo; Kamei, Noriyasu; Murata, Yoji; Takayama, Kozo; Matozaki, Takashi; Takeda-Morishita, Mariko

    2017-09-01

    The stomach cancer-associated protein tyrosine phosphatase 1 (SAP-1) is a receptor-type protein tyrosine phosphatase that is specifically expressed on the apical membrane of the intestinal epithelium. SAP-1 is known to maintain the balance of phosphorylation of proteins together with protein kinases; however, its biological function and impact on pharmacokinetics in the intestine remain unclear. The present study, therefore, aimed at clarifying the relationship between SAP-1 and the intestinal absorption behaviors of typical transporter substrates and macromolecules. The endogenous levels of glucose and total cholesterol in the blood were similar between wild-type and SAP-1-deficient mice (Sap1 -/- ), suggesting no contribution of SAP-1 to biogenic influx. Moreover, in vitro transport study with everted ileal sacs demonstrated that there was no difference in the absorption of breast cancer resistance protein, P-glycoprotein, and peptide transporter substrates between both mice. However, absorptive clearance of macromolecular model dextrans (FD-4 and FD-10) in Sap1 -/- mice was significantly higher than that in wild-type mice, and this was confirmed by the trend of increased FD-4 absorption from colonic loops of Sap1 -/- mice. Therefore, the results of this study suggest the partial contribution of SAP-1 to the regulated transport of hydrophilic macromolecules through paracellular tight junctions. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  19. Elevated uptake of plasma macromolecules by regions of arterial wall predisposed to plaque instability in a mouse model.

    Directory of Open Access Journals (Sweden)

    Zahra Mohri

    Full Text Available Atherosclerosis may be triggered by an elevated net transport of lipid-carrying macromolecules from plasma into the arterial wall. We hypothesised that whether lesions are of the thin-cap fibroatheroma (TCFA type or are less fatty and more fibrous depends on the degree of elevation of transport, with greater uptake leading to the former. We further hypothesised that the degree of elevation can depend on haemodynamic wall shear stress characteristics and nitric oxide synthesis. Placing a tapered cuff around the carotid artery of apolipoprotein E -/- mice modifies patterns of shear stress and eNOS expression, and triggers lesion development at the upstream and downstream cuff margins; upstream but not downstream lesions resemble the TCFA. We measured wall uptake of a macromolecular tracer in the carotid artery of C57bl/6 mice after cuff placement. Uptake was elevated in the regions that develop lesions in hyperlipidaemic mice and was significantly more elevated where plaques of the TCFA type develop. Computational simulations and effects of reversing the cuff orientation indicated a role for solid as well as fluid mechanical stresses. Inhibiting NO synthesis abolished the difference in uptake between the upstream and downstream sites. The data support the hypothesis that excessively elevated wall uptake of plasma macromolecules initiates the development of the TCFA, suggest that such uptake can result from solid and fluid mechanical stresses, and are consistent with a role for NO synthesis. Modification of wall transport properties might form the basis of novel methods for reducing plaque rupture.

  20. Treatment of the press residues of pressed grapes on an industrial scale

    Energy Technology Data Exchange (ETDEWEB)

    1978-04-24

    EtOH and tartaric acid are recovered from press residues of grapes by distillation and concentration of the EtOH and extraction of the dried residue after removal of seeds with a mixture of H/sub 2/O and mineral acid. Vegetable oil is extracted from the seeds. Collidal substances are coagulated by roasting prior to extraction of tartaric acid. The grape skins are recovered in flake form.

  1. Press conference of the 15 october 2002; Conference de presse du 15 octobre 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-10-01

    Facing the public hostile purposes of october 2002, concerning the renewable energies, Andre Antolini, President of the renewable energies syndicate, proposed a press conference to give information, data and realizations on the renewable energies. The text of the conference is presented, as data on employment, biofuels, the wind energy, the hydro-electricity the greenhouse effect fight, the public opinion, the solar heating, the photovoltaic and the future projects and electric power supply for 2010. (A.L.B.)

  2. Hot isostatic press waste option study report

    International Nuclear Information System (INIS)

    Russell, N.E.; Taylor, D.D.

    1998-02-01

    A Settlement Agreement between the Department of Energy and the State of Idaho mandates that all high-level radioactive waste now stored at the Idaho Chemical Processing Plant be treated so that it is ready to move out of Idaho for disposal by the target date of 2035. This study investigates the immobilization of all Idaho Chemical Processing Plant calcine, including calcined sodium bearing waste, via the process known as hot isostatic press, which produces compact solid waste forms by means of high temperature and pressure (1,050 C and 20,000 psi), as the treatment method for complying with the settlement agreement. The final waste product would be contained in stainless-steel canisters, the same type used at the Savannah River Site for vitrified waste, and stored at the Idaho National Engineering and Environmental Laboratory until a national geological repository becomes available for its disposal. The waste processing period is from 2013 through 2032, and disposal at the High Level Waste repository will probably begin sometime after 2065

  3. [Work disability in public press professions].

    Science.gov (United States)

    Akermann, S

    2002-09-01

    In this study more than 1,000 cases of long-term disability among members of the press and media were evaluated. Mental disorders were the main cause of disability in almost every fourth case. In women psychiatric illnesses were even more important. The most common diagnosis was that of a depressive disorder which accounted for more than half of all psychiatric cases. The causes of disability of other insurance systems such as the German social security scheme and the pension and disability plan for the medical profession were compared. Mental illnesses are the leading cause of disability in white collar workers and orthopaedic illnesses, especially disorders of the vertebral column, are the leading cause in blue collar workers, as one might have expected. In females mental disorders are even more common than in men whereas men tend to have more cardiovascular problems than women. In this study also some interesting features regarding disability caused by various illnesses after long-term follow-up were found. This opens unknown perspectives allowing new assessment of diseases and eventually will enable the actuary to price medical diagnoses for disability insurance.

  4. Pressing problems of measurement of ionizing radiations

    International Nuclear Information System (INIS)

    Fominykh, V.I.; Yudin, M.F.

    1993-01-01

    The current system for ensuring the unity of measurements in the Russian Federation and countries of the former Soviet Union ensures a high quality of dosimetric, radiometric, and spectrometric measurements in accordance with the recommendations of the Consulative Committee on Standards for Measurements of Ionizing Radiations of the International Bureau of Weights and Measures (IBWM), International Organization on Radiological Units (ICRU), International Commission on Radiological Protection (ICRP), International Organization on Legislative Metrology (IOLM), International Atomic Energy Agency (IAEA), World Health Organization (WHO), etc. Frequent collation of the national primary and secondary standards of Russia with those of IBWM and the leading national laboratories of the world facilitate mutual verification of the measurements of ionizing radiations. The scope of scientific and scientific-technical problems that can be solved by using ionizing radiations has expanded significantly in recent years. In this paper the authors consider some pressing problems of the metrology of ionizing radiations which have arisen as a result of this expansion. These include the need for unity and reliability of measurements involved in radiation protection, the measurement of low doses involving low dose rates, ensuring the unity of measurements when monitoring the radiological security of the population, the need for more uniformity on an international scale regarding the basic physical quantities and their units for characterizing radiation fields, determination of the accuracy of measurement of the radiation dose absorbed by an irradiated tissue or organ, and the development of complex standards for ionizing radiations. 5 refs., 1 tab

  5. Hot isostatic press waste option study report

    Energy Technology Data Exchange (ETDEWEB)

    Russell, N.E.; Taylor, D.D.

    1998-02-01

    A Settlement Agreement between the Department of Energy and the State of Idaho mandates that all high-level radioactive waste now stored at the Idaho Chemical Processing Plant be treated so that it is ready to move out of Idaho for disposal by the target date of 2035. This study investigates the immobilization of all Idaho Chemical Processing Plant calcine, including calcined sodium bearing waste, via the process known as hot isostatic press, which produces compact solid waste forms by means of high temperature and pressure (1,050 C and 20,000 psi), as the treatment method for complying with the settlement agreement. The final waste product would be contained in stainless-steel canisters, the same type used at the Savannah River Site for vitrified waste, and stored at the Idaho National Engineering and Environmental Laboratory until a national geological repository becomes available for its disposal. The waste processing period is from 2013 through 2032, and disposal at the High Level Waste repository will probably begin sometime after 2065.

  6. Distal clavicular osteolysis in adults: association with bench pressing intensity

    International Nuclear Information System (INIS)

    Nevalainen, Mika T.; Morrison, William B.; Zoga, Adam C.; Roedl, Johannes B.; Ciccotti, Michael G.

    2016-01-01

    To investigate the association between distal clavicular osteolysis (DCO) and bench pressing intensity. From a retrospective review of MRI shoulder reports of individuals between 20 and 40 years of age, 262 male patients with DCO and 227 age-matched male patients without DCO were selected. All patients had completed a bench pressing questionnaire. The patients' bench pressing frequency (times per week), duration (years of bench pressing), bench pressing weight (maximum bench pressing weight with one repetition = 1RM) and the ratio of bench pressing weight to body weight were compared between both groups using Chi-square and Mann-Whitney tests. The results showed that 56 % (146/262) of patients with DCO were high-intensity bench pressers (1RM more than 1.5 times the body weight) compared to 6 % (14/227) in patients without DCO. High-intensity bench pressing was a risk factor for DCO (OR = 19; 95 %CI = 11-35; p 1 x /week) and duration (>5 years) of bench pressing were risk factors. In bench pressers who suffered from DCO, the mean 1RM was 283 lbs (±SD 57) compared to 209 lbs (±SD 60) in bench pressers not affected by DCO (p < 0.001, Mann-Whitney). High-intensity, but not low-intensity bench pressing is a risk factor for DCO. (orig.)

  7. Zinc coated sheet steel for press hardening

    Science.gov (United States)

    Ghanbari, Zahra N.

    Galvanized steels are of interest to enhance corrosion resistance of press-hardened steels, but concerns related to liquid metal embrittlement have been raised. The objective of this study was to assess the soak time and temperature conditions relevant to the hot-stamping process during which Zn penetration did or did not occur in galvanized 22MnB5 press-hardening steel. A GleebleRTM 3500 was used to heat treat samples using hold times and temperatures similar to those used in industrial hot-stamping. Deformation at both elevated temperature and room temperature were conducted to assess the coating and substrate behavior related to forming (at high temperature) and service (at room temperature). The extent of alloying between the coating and substrate was assessed on undeformed samples heat treated under similar conditions to the deformed samples. The coating transitioned from an α + Gamma1 composition to an α (bcc Fe-Zn) phase with increased soak time. This transition likely corresponded to a decrease in availability of Zn-rich liquid in the coating during elevated temperature deformation. Penetration of Zn into the substrate sheet in the undeformed condition was not observed for any of the processing conditions examined. The number and depth of cracks in the coating and substrate steel was also measured in the hot-ductility samples. The number of cracks appeared to increase, while the depth of cracks appeared to decrease, with increasing soak time and increasing soak temperature. The crack depth appeared to be minimized in the sample soaked at the highest soak temperature (900 °C) for intermediate and extended soak times (300 s or 600 s). Zn penetration into the substrate steel was observed in the hot-ductility samples soaked at each hold temperature for the shortest soak time (10 s) before being deformed at elevated temperature. Reduction of area and elongation measurements showed that the coated sample soaked at the highest temperature and longest soak time

  8. Hot pressing of B4C/SiC composites

    International Nuclear Information System (INIS)

    Sahin, F.C.; Turhan, E.; Yesilcubuk, S.A.; Addemir, O.

    2005-01-01

    B 4 C/SiC ceramic composites containing 10-20-30 vol % SiC were prepared by hot pressing method. The effect of SiC addition and hot pressing temperature on sintering behaviour and mechanical properties of hot pressed composites were investigated. Microstructures of hot pressed samples were examined by SEM technique. Three different temperatures (2100 deg. C, 2200 deg. C and 2250 deg. C) were used to optimize hot pressing temperature applying 100 MPa pressure under argon atmosphere during the sintering procedure. The highest relative density of 98.44 % was obtained by hot pressing at 2250 deg. C. However, bending strengths of B 4 C/SiC composite samples were lower than monolithic B 4 C in all experimental conditions. (authors)

  9. Auxiliary equipment and special techniques used for hot isostatic pressing

    International Nuclear Information System (INIS)

    Pfeffer, J.B.; Odebo, U.

    1977-01-01

    The largest use for hot isostatic pressing (HIP) in production is in the consolidation of powder. In principle, powder is filled into a capsule of metal or glass, and the capsule is evacuated, sealed and loaded into the hot isostatic press. Consolidation takes place in the hot isostatic press, at which time the consolidated capsule is removed from the press and the encapsulation material is removed from the consolidated powder body. In both densification and defect healing, HIP is carried out without encapsulating the material. This is possible as the materials that lend themselves to HIP healing initially have a high density without communicating pores; therefore, the material acts as its own capsule. Considerations outside of the hot isostatic press that must be taken into account are examined. Information is included on powder manufacture, fabrication of capsules, powder handling, capsule sealing, and loading and unloading the press

  10. High density high-TC ceramic superconductors by hot pressing

    International Nuclear Information System (INIS)

    Mak, S.; Chaklader, A.C.D.

    1989-01-01

    High density and high T C superconductor specimens, YBa 2 Cu 3 O x , have been produced by hot-pressing. The factors studied are the effect of hot pressing on the density, the oxygen stoichiometry, the crystal structure, and the critical temperature. Hot pressing followed by heat treatment increased the density of the specimen to 93%. The hot pressing itself did not significantly affect the oxygen content in the specimen, and although the crystal structure appeared to be orthorhombic, the specimens were not superconducting above liquid nitrogen temperature. The superconductivity was restored after head treatment in oxygen. The highest critical temperature (T C ) of the hot pressed pellets was 82K, which was slightly lower than the T C that could be obtained with the cold pressed/sintered pellets. (6 refs., 5 figs., tab.)

  11. Direct drive digital servo press with high parallel control

    Science.gov (United States)

    Murata, Chikara; Yabe, Jun; Endou, Junichi; Hasegawa, Kiyoshi

    2013-12-01

    Direct drive digital servo press has been developed as the university-industry joint research and development since 1998. On the basis of this result, 4-axes direct drive digital servo press has been developed and in the market on April of 2002. This servo press is composed of 1 slide supported by 4 ball screws and each axis has linearscale measuring the position of each axis with high accuracy less than μm order level. Each axis is controlled independently by servo motor and feedback system. This system can keep high level parallelism and high accuracy even with high eccentric load. Furthermore the 'full stroke full power' is obtained by using ball screws. Using these features, new various types of press forming and stamping have been obtained by development and production. The new stamping and forming methods are introduced and 'manufacturing' need strategy of press forming with high added value and also the future direction of press forming are also introduced.

  12. Muscle activation when performing the chest press and shoulder press on a stable bench vs. a Swiss ball.

    Science.gov (United States)

    Uribe, Brandon P; Coburn, Jared W; Brown, Lee E; Judelson, Daniel A; Khamoui, Andy V; Nguyen, Diamond

    2010-04-01

    The aim of this study was to examine the effects of a stable surface (bench) vs. an unstable surface (Swiss ball) on muscle activation when performing the dumbbell chest press and shoulder press. Sixteen healthy men (24.19 +/- 2.17 years) performed 1 repetition maximum (1RM) tests for the chest press and shoulder press on a stable surface. A minimum of 48 hours post 1RM, subjects returned to perform 3 consecutive repetitions each of the chest press and shoulder press at 80% 1RM under 4 different randomized conditions (chest press on bench, chest press on Swiss ball, shoulder press on bench, shoulder press on Swiss ball). Electromyography was used to assess muscle activation of the anterior deltoid, pectoralis major, and rectus abdominus. The results revealed no significant difference in muscle activation between surface types for either exercise. This suggests that using an unstable surface neither improves nor impairs muscle activation under the current conditions. Coaches and other practitioners can expect similar muscle activation when using a Swiss ball vs. a bench.

  13. Legal Protection To The Infotainment Of Press Development In Indonesia

    Directory of Open Access Journals (Sweden)

    Anwar Fuadi

    2015-08-01

    Full Text Available Abstract In the socio-political life the press has become an integral part in democratic life. The press has become one of the means for citizens to bring their thoughts and opinions. Nowadays there is a tendency to increase the quantity of press publications sharp but not accompanied by a statement of the quality of journalism. The objective of this research is to understand the essence of the infotainment liability as a mass media in order to construct a freedom of the press principle which has legitimacy within the legal system of the press in Indonesia. The type of research used in this paper is normative research or also known as doctrinal research by reviewing the legal protection to the infotainment as a mass media in Indonesia. The outcomes of the research indicate that the role of infotainment in the legal system of the press in Indonesia refers to the legal construction of institutional and infotainment organizers itself. Legal liability of Infotainment essentially can be seen from the press obligations stipulated in the Law No. 40 of 1999 regarding the Press Law No. 32 of 2002 regarding Broadcasting as well as the Journalists Code of Ethics which support freedom of the press and expression.

  14. The small academic press in the land of giants

    Directory of Open Access Journals (Sweden)

    Frances Pinter

    2015-11-01

    Full Text Available Mergers and acquisitions, for example the merger of Macmillan Science and Education with Springer Science+Business Media, might suggest that large is the future for academic publishing.  It might seem that giant players will dominate the future of scholarly publishing, but, at the same time, this year has seen the launch of UCL Press, the University’s in-house publishing arm. Goldsmiths, University of London, has also announced it is preparing to launch Goldsmiths Press, a new university press built on digital-first publishing, especially around unconventional projects traditionally excluded by publishers. Some of the more established university presses also seem to be increasing their scope. For example, Stanford University Press launched a new trade imprint and Manchester University Press has announced it has acquired forward titles from Bloomsbury Publishing.  'Insights 'asked two experts if there really is scope for the small academic press in the modern scholarly publishing environment. Frances Pinter has provided the perspective of the small university press. She is realistic about the challenges small academic publishers face, but concludes that there is space and opportunity for them to coexist with the giants. Michael Magoulias is equally realistic about the challenges of small, but sees the university press as a necessary, not to say, vital, alternative to commercial publishing.

  15. WordPress all-in-one for dummies

    CERN Document Server

    Sabin-Wilson, Lisa; Palmer, Kevin

    2011-01-01

    A convenient how-to guide for maximizing your WordPress experience. WordPress is a state-of-the-art blog publishing platform with nearly ten million active installations. Eight minibooks provide you with expanded coverage of the most important topics to the WordPress community, such as WordPress basics, theme designs, plug-in development, social media integration, SEO, customization, and running multiple sites. Veteran author Lisa Sabin-Wilson leads an authoritative team of authors who offer their unique knowledge and skillset while sharing invaluable advice for maximizing your site's potentia

  16. Effects of pressing temperature and initial microstructure on the equal channel angular pressing of Ti-6Al-4V alloy

    International Nuclear Information System (INIS)

    Ko, Y.G.; Lee, Y.H.; Jung, W.S.; Shin, D.H.; Lee, C.S.

    2003-01-01

    The effects of pressing temperature and initial microstructure on the equal channel angular (ECA) pressing of Ti-6Al-4V alloy were investigated in this study. The ECA pressing was carried out isothermally with route C at 500 C, 600 C and 700 C for two typical microstructures, i.e., the Widmanstaetten microstructure and the equiaxed microstructure. The results showed that ECA pressing at 600 C and 700 C was successful without producing any noticeable segment at the specimen surfaces, while a large amount of surface segments were produced at 500 C. After 1 pass pressing at 600 C, the equiaxed microstructure showed more uniform material flow at the surface than the Widmanstaetten microstructure. However, this microstructural influence was diminished with increase of the number of the ECA pressing. A flow-localization parameter that quantifies the flow non-uniform tendency in case of flow softening materials was used to explain the different results in each microstructure. (orig.)

  17. The LNG industry in 2011. Press revue

    International Nuclear Information System (INIS)

    2012-05-01

    The outlook of the LNG industry in 2011 is presented as a revue of press articles: The role of LNG as a flexible and secure energy source as well as the prompt response to provide back-up through additional supplies and cargo diversions to compensate for the sudden loss of nuclear capacity in Japan - with sellers exercising due price restraint in view of the human tragedy - has been a credit to the industry. The increase in production capacity in 2009 and 2010, in particular from Qatar, had permitted the necessary buffer to cope much better with the demand surge than during past disruptions (such as the aftermath of the Chuetsu earthquake in late 2007). Undoubtedly, the marked shift over the last decade in the industry's prevailing business model towards global trade, destination flexibility and portfolio play has also facilitated the rapid response. As the total volume of LNG trade is very much determined by the availability of supply, 2011 has seen a growth of 9.4% over 2010, mainly as a result of the full availability of the six Qatar mega-trains over the past year. On the demand side the two traditional basins have shown very contrasting trends: 15% higher LNG off-take in Asia (the five major markets all increasing between 37.4% and 8.9%), versus a 1.7% decrease in the Atlantic Basin. Cargo diversions and an increasing number of reloads have boosted the exports from the Atlantic Basin to Asia in 2011 to more than 14 million tons (equivalent to more than 200 large size cargoes). Remarkable is also the fast growth in new markets in Latin America and in the Middle East - albeit from a small base - with counter-seasonal but varying demand, offering attractive arbitrage opportunities to portfolio play. Not surprising then that 2011 has seen another hike in spot and short-term trade, not just in absolute terms but also as a percentage of total trade (50% over 2010, 25.4% of total trade). The outlook for LNG is strong and its global demand prospects further

  18. Deep learning-based subdivision approach for large scale macromolecules structure recovery from electron cryo tomograms.

    Science.gov (United States)

    Xu, Min; Chai, Xiaoqi; Muthakana, Hariank; Liang, Xiaodan; Yang, Ge; Zeev-Ben-Mordehai, Tzviya; Xing, Eric P

    2017-07-15

    Cellular Electron CryoTomography (CECT) enables 3D visualization of cellular organization at near-native state and in sub-molecular resolution, making it a powerful tool for analyzing structures of macromolecular complexes and their spatial organizations inside single cells. However, high degree of structural complexity together with practical imaging limitations makes the systematic de novo discovery of structures within cells challenging. It would likely require averaging and classifying millions of subtomograms potentially containing hundreds of highly heterogeneous structural classes. Although it is no longer difficult to acquire CECT data containing such amount of subtomograms due to advances in data acquisition automation, existing computational approaches have very limited scalability or discrimination ability, making them incapable of processing such amount of data. To complement existing approaches, in this article we propose a new approach for subdividing subtomograms into smaller but relatively homogeneous subsets. The structures in these subsets can then be separately recovered using existing computation intensive methods. Our approach is based on supervised structural feature extraction using deep learning, in combination with unsupervised clustering and reference-free classification. Our experiments show that, compared with existing unsupervised rotation invariant feature and pose-normalization based approaches, our new approach achieves significant improvements in both discrimination ability and scalability. More importantly, our new approach is able to discover new structural classes and recover structures that do not exist in training data. Source code freely available at http://www.cs.cmu.edu/∼mxu1/software . mxu1@cs.cmu.edu. Supplementary data are available at Bioinformatics online. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

  19. Exploring the structure of biological macromolecules in solution using Quokka, the small angle neutron scattering instrument, at ANSTO

    International Nuclear Information System (INIS)

    Wood, Kathleen; Jeffries, Cy M.; Knott, Robert B.; Sokolova, Anna; Jacques, David A.; Duff, Anthony P.

    2015-01-01

    Small angle neutron scattering (SANS) is widely used to extract structural parameters, shape and other types of information from a vast array of materials. The technique is applied to biological macromolecules and their complexes in solution to reveal information often not accessible by other techniques. SANS measurements on biomolecules present some particular challenges however, one of which is suitable instrumentation. This review details SANS experiments performed on two well-characterised globular proteins (lysozyme and glucose isomerase) using Quokka, the recently commissioned SANS instrument at the Australian Nuclear Science and Technology Organisation (ANSTO). The instrument configuration as well as data collection and reduction strategies for biological investigations are discussed and act as a general reference for structural biologists who use the instrument. Both model independent analysis of the two proteins and ab initio modelling illustrate that Quokka-SANS data can be used to successfully model the overall shapes of proteins in solution, providing a benchmark for users

  20. From the Cover: Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies

    Science.gov (United States)

    McAllister, Devin V.; Wang, Ping M.; Davis, Shawn P.; Park, Jung-Hwan; Canatella, Paul J.; Allen, Mark G.; Prausnitz, Mark R.

    2003-11-01

    Arrays of micrometer-scale needles could be used to deliver drugs, proteins, and particles across skin in a minimally invasive manner. We therefore developed microfabrication techniques for silicon, metal, and biodegradable polymer microneedle arrays having solid and hollow bores with tapered and beveled tips and feature sizes from 1 to 1,000 μm. When solid microneedles were used, skin permeability was increased in vitro by orders of magnitude for macromolecules and particles up to 50 nm in radius. Intracellular delivery of molecules into viable cells was also achieved with high efficiency. Hollow microneedles permitted flow of microliter quantities into skin in vivo, including microinjection of insulin to reduce blood glucose levels in diabetic rats. transdermal drug delivery | skin | microelectromechanical systems | solid microneedle | hollow needle injection

  1. Distal clavicular osteolysis in adults: association with bench pressing intensity

    Energy Technology Data Exchange (ETDEWEB)

    Nevalainen, Mika T.; Morrison, William B.; Zoga, Adam C.; Roedl, Johannes B. [Sidney Kimmel Medical College at Thomas Jefferson University, Division of Musculoskeletal Imaging and Interventions, Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA (United States); Ciccotti, Michael G. [Sidney Kimmel Medical College at Thomas Jefferson University, Division of Sports Medicine, Department of Orthopedic Surgery, Thomas Jefferson University Hospital, Rothman Institute, Philadelphia, PA (United States)

    2016-11-15

    To investigate the association between distal clavicular osteolysis (DCO) and bench pressing intensity. From a retrospective review of MRI shoulder reports of individuals between 20 and 40 years of age, 262 male patients with DCO and 227 age-matched male patients without DCO were selected. All patients had completed a bench pressing questionnaire. The patients' bench pressing frequency (times per week), duration (years of bench pressing), bench pressing weight (maximum bench pressing weight with one repetition = 1RM) and the ratio of bench pressing weight to body weight were compared between both groups using Chi-square and Mann-Whitney tests. The results showed that 56 % (146/262) of patients with DCO were high-intensity bench pressers (1RM more than 1.5 times the body weight) compared to 6 % (14/227) in patients without DCO. High-intensity bench pressing was a risk factor for DCO (OR = 19; 95 %CI = 11-35; p < 0.001). Low-intensity bench pressing (1RM less than 1.5 times the body weight) was not a risk factor for DCO (OR = 0.6; 95 % CI = 0.4-0.8). High frequency (>1 x /week) and duration (>5 years) of bench pressing were risk factors. In bench pressers who suffered from DCO, the mean 1RM was 283 lbs (±SD 57) compared to 209 lbs (±SD 60) in bench pressers not affected by DCO (p < 0.001, Mann-Whitney). High-intensity, but not low-intensity bench pressing is a risk factor for DCO. (orig.)

  2. Micropore surface area of alkali-soluble plant macromolecules (humic acids) drives their decomposition rates in soil.

    Science.gov (United States)

    Papa, Gabriella; Spagnol, Manuela; Tambone, Fulvia; Pilu, Roberto; Scaglia, Barbara; Adani, Fabrizio

    2010-02-01

    Previous studies suggested that micropore surface area (MSA) of alkali-soluble bio-macromolecules of aerial plant residues of maize constitutes an important factor that explains their humification in soil, that is, preservation against biological degradation. On the other hand, root plant residue contributes to the soil humus balance, as well. Following the experimental design used in a previous paper published in this journal, this study shows that the biochemical recalcitrance of the alkali-soluble acid-insoluble fraction of the root plant material, contributed to the root maize humification of both Wild-type maize plants and its corresponding mutant brown midrib (bm3), this latter characterized by reduced lignin content. Humic acids (HAs) existed in root (root-HAs) were less degraded in soil than corresponding HAs existed in shoot (shoot-HAs): shoot-HAs bm3 (48%)>shoot-HAs Wild-type (37%)>root-HAs Wild-type (33%)>root-HAs bm3 (22%) (degradability shown in parenthesis). These differences were related to the MSA of HAs, that is, root-HAs having a higher MSA than shoot-HAs: shoot-HAs bm3 (41.43+/-1.2m(2)g(-1))macromolecules recalcitrance in soil.

  3. Preparation, definition and stabilisation of an inorganic sol by an organic macromolecule: case of an aluminium hydroxide colloid

    International Nuclear Information System (INIS)

    Hurbin-Faucon, A.

    1966-01-01

    An attempt has been made in this work to define an aluminium colloid which is resistant as a high ionic force and to analyse, in the case of this system, the possibilities. and the limits of certain techniques used in the physical chemistry of colloids. The aluminium colloid is obtained by peptization of an aluminium hydroxide precipitate. The physical characterisation of the micelle is effected using the light scattering method which makes it possible to define the colloid from the point of view of size and shape. An interesting characteristic, arising from the low refractive index of the colloid studied, has led us to use not only the general MIE methods but also the methods normally used in macro-molecular chemistry; these latter involve fewer hypotheses and thus make it possible to carry out a more complete analysis of the sol. Since the aluminium hydroxide colloid is sensitive to a high ionic force, we have begun to study the possibility of making it more stable by means of a macromolecule: gelatin. After characterizing this macromolecule by means of potentiometric and light scattering measurements, we have shown the existence of a chemical interaction which occurs when aluminium hydroxide is brought into contact with gelatin; this interaction leads to the production of an inorganic-organic entity which is stable when the ionic force increases. We have established some of the characteristics of the complex thus formed, in particular the pH range of the solution necessary for its formation, its stability. in the presence of electrolytes and some hypotheses concerning its size and shape, Finally we have tried to define the influence of. the molecular weight and the respective dimensions of each constituent on the formation of the complex and thus on the stabilization. (author) [fr

  4. Press touch code: A finger press based screen size independent authentication scheme for smart devices

    Science.gov (United States)

    Ranak, M. S. A. Noman; Nor, Nur Nadiah Hanim Binti Mohd; Zamli, Kamal Z.

    2017-01-01

    Due to recent advancements and appealing applications, the purchase rate of smart devices is increasing at a higher rate. Parallely, the security related threats and attacks are also increasing at a greater ratio on these devices. As a result, a considerable number of attacks have been noted in the recent past. To resist these attacks, many password-based authentication schemes are proposed. However, most of these schemes are not screen size independent; whereas, smart devices come in different sizes. Specifically, they are not suitable for miniature smart devices due to the small screen size and/or lack of full sized keyboards. In this paper, we propose a new screen size independent password-based authentication scheme, which also offers an affordable defense against shoulder surfing, brute force, and smudge attacks. In the proposed scheme, the Press Touch (PT)—a.k.a., Force Touch in Apple’s MacBook, Apple Watch, ZTE’s Axon 7 phone; 3D Touch in iPhone 6 and 7; and so on—is transformed into a new type of code, named Press Touch Code (PTC). We design and implement three variants of it, namely mono-PTC, multi-PTC, and multi-PTC with Grid, on the Android Operating System. An in-lab experiment and a comprehensive survey have been conducted on 105 participants to demonstrate the effectiveness of the proposed scheme. PMID:29084262

  5. Press touch code: A finger press based screen size independent authentication scheme for smart devices.

    Science.gov (United States)

    Ranak, M S A Noman; Azad, Saiful; Nor, Nur Nadiah Hanim Binti Mohd; Zamli, Kamal Z

    2017-01-01

    Due to recent advancements and appealing applications, the purchase rate of smart devices is increasing at a higher rate. Parallely, the security related threats and attacks are also increasing at a greater ratio on these devices. As a result, a considerable number of attacks have been noted in the recent past. To resist these attacks, many password-based authentication schemes are proposed. However, most of these schemes are not screen size independent; whereas, smart devices come in different sizes. Specifically, they are not suitable for miniature smart devices due to the small screen size and/or lack of full sized keyboards. In this paper, we propose a new screen size independent password-based authentication scheme, which also offers an affordable defense against shoulder surfing, brute force, and smudge attacks. In the proposed scheme, the Press Touch (PT)-a.k.a., Force Touch in Apple's MacBook, Apple Watch, ZTE's Axon 7 phone; 3D Touch in iPhone 6 and 7; and so on-is transformed into a new type of code, named Press Touch Code (PTC). We design and implement three variants of it, namely mono-PTC, multi-PTC, and multi-PTC with Grid, on the Android Operating System. An in-lab experiment and a comprehensive survey have been conducted on 105 participants to demonstrate the effectiveness of the proposed scheme.

  6. Densification of boron carbide at relatively low temperatures by hot pressing and hot isostatic pressing

    International Nuclear Information System (INIS)

    Telle, R.

    1988-01-01

    The poor sinterability of B 4 C limits its widespread application because both high temperatures and high pressures are required for a complete densification. Moreover, B 4 C suffers from a low strength and fracture toughness, possesses, however, a high potential because of its extreme hardness. Reaction hot pressing of B 4 C-WC-TiC-Si-Co mixtures resulting in B 4 C-TiB 2 -W 2 B 5 composites of high density exhibit remarkable mechanical properties. The influence of hot isostatic pressing (HIP) on the microstructure and the mechanical properties is investigated in cooperation with participants of the COST 503 activities and related to the strengthening and toughening mechanisms. Difficulties during densification by HIP arise from the evaporation of adsorbed volatiles as well as from the strong swelling of the powder compact due to the sintering reaction. Several HIP cycle designs were tested in order to prevent the bloating of the capsule and to control internal stresses due to the misfit of the thermal expansion of the entire phases. In comparison to single phase B 4 C ceramics, bending strength was improved to 1030 MPa, K Ic to 5.2 MPa/m, while hardness was comparable with HV1=38 GPa. Wear test were performed and related to the toughening mechanisms. (orig.) With 56 refs., 9 tabs., 64 figs

  7. Press touch code: A finger press based screen size independent authentication scheme for smart devices.

    Directory of Open Access Journals (Sweden)

    M S A Noman Ranak

    Full Text Available Due to recent advancements and appealing applications, the purchase rate of smart devices is increasing at a higher rate. Parallely, the security related threats and attacks are also increasing at a greater ratio on these devices. As a result, a considerable number of attacks have been noted in the recent past. To resist these attacks, many password-based authentication schemes are proposed. However, most of these schemes are not screen size independent; whereas, smart devices come in different sizes. Specifically, they are not suitable for miniature smart devices due to the small screen size and/or lack of full sized keyboards. In this paper, we propose a new screen size independent password-based authentication scheme, which also offers an affordable defense against shoulder surfing, brute force, and smudge attacks. In the proposed scheme, the Press Touch (PT-a.k.a., Force Touch in Apple's MacBook, Apple Watch, ZTE's Axon 7 phone; 3D Touch in iPhone 6 and 7; and so on-is transformed into a new type of code, named Press Touch Code (PTC. We design and implement three variants of it, namely mono-PTC, multi-PTC, and multi-PTC with Grid, on the Android Operating System. An in-lab experiment and a comprehensive survey have been conducted on 105 participants to demonstrate the effectiveness of the proposed scheme.

  8. Atlas of hot isostatic beryllium powder pressing diagrams

    International Nuclear Information System (INIS)

    Stoev, P.I.; Papirov, I.I.; Tikhinskij, G.F.; Vasil'ev, A.A.

    1995-01-01

    Diagrams of hot isotopic pressing (HIP) of beryllium powder with different grain size in a wide range of pressing parameters are built by mathematical modeling methods. The HIP diagrams presented are divided into 3 groups: parametric dependencies D=f(P,T); technological HIP diagrams; compacting mechanisms. The created data bank permits to optimise beryllium powder HIP with changing parameters. 4 refs., 23 figs

  9. Simulation Model of Automated Peat Briquetting Press Drive

    Directory of Open Access Journals (Sweden)

    A. A. Marozka

    2012-01-01

    Full Text Available The paper presents the developed fully functional simulation model of an automated peat briquetting press drive. The given model makes it possible to reduce financial and time costs while developing, designing and operating a double-stamp peat briquetting press drive.

  10. Criticism of the Press: Its Social, Psychological and Political Origins.

    Science.gov (United States)

    Becker, Lee B.; And Others

    This study examines data from several national polls about press coverage during the Watergate scandal, in order to assess the origins of press criticism. The polls were conducted between 28 September and 6 October 1973, during June 1974, and in August 1974. The data suggest that political variables--particularly support of Nixon, party…

  11. Design, manufacture and performance research of double acting hydraulic press

    OpenAIRE

    Koc, Erdem; Unver, Ertu; Ozturk, Hidayet

    1990-01-01

    This research presents the design and production of a double acting 40 tons capacity hydraulic press. The issues in the design, engineering manufacturing of the hydraulic press are reported specifically on both cylinders generating the same pressure and velocity using a solenoid directional control valve and a flow separating valve. (In Turkish)

  12. New Realities for Scholarly Presses in Trying Economic Times

    Science.gov (United States)

    Blakesley, David

    2014-01-01

    The author explains that Parlor Press is an independent publisher and distributor of scholarly and trade books in print and digital formats. It was founded in 2002 to address the need for an alternative scholarly, academic press attentive to emergent ideas and forms while maintaining the highest possible standards of quality, credibility, and…

  13. News from the Library: PressDisplay on mobile devices!

    CERN Multimedia

    CERN Library

    2013-01-01

    You are probably already using PressDisplay to read newspapers online, but for those of you who are not yet aware of this service, PressDisplay is an online portal where you can browse and read online articles from more than 1,900 newspapers from 95 countries, as soon as they are published.   Whether you are an experienced user or a beginner, we have good news concerning PressDisplay: our license now permits you to download complete newspaper issues to your mobile devices and read them offline wherever you like. To do that, you have to use the mobile app PressReader. Instructions on how to install the PressReader app are available here: For Ipad For Android smartphone For Android tablet For Windows 8 devices For BlackBerry Playbook For Android eReader Your feedback is welcome! Please contact us by e-mail.

  14. Predictor of regulation of uranium dioxide powder pressing process

    International Nuclear Information System (INIS)

    Motta, Eduardo Souza; Araujo, Victor Hugo Leal de; Bernardelli, Sergio Henrique

    2007-01-01

    One of the most important steps of the uranium dioxide pellets fabrication used in the nuclear fuel elements is the green pellets pressing. The target density of the pellets after the sintering process determines the density of the green pellet. To meet the same sintered target density the green density may vary according to the powder characteristics. These variations implies in changing the regulation of the press for different powder's patches. The regulation done empirically imply in productivity loss and necessity of reprocessing the pellets pressed during the press regulation and also depends on the operator experience. At this work, was developed an artificial neural network feed forward back propagation to predict the press regulation, depending on the powder characteristics and the green pellet's target density. The results obtained at INB - Industrias Nucleares do Brasil S. A. during the fabrication of the fifth recharge of Angra II nuclear power plant are presented. (author)

  15. The chain length of lignan macromolecule from flaxseed hulls is determined by the incorporation of coumaric acid glucosides and ferulic acid glucosides

    NARCIS (Netherlands)

    Struijs, K.; Vincken, J.P.; Doeswijk, T.G.; Voragen, A.G.J.; Gruppen, H.

    2009-01-01

    Lignan macromolecule from flaxseed hulls is composed of secoisolariciresinol diglucoside (SDG) and herbacetin diglucoside (HDG) moieties ester-linked by 3-hydroxy-3-methylglutaric acid (HMGA), and of p-coumaric acid glucoside (CouAG) and ferulic acid glucoside (FeAG) moieties ester-linked directly

  16. How to press-release and take care of expression in articles at press side

    International Nuclear Information System (INIS)

    Hamamoto, Kazuko; Narabayashi, Tadashi; Kobayashi, Masahide; Akizuki, Teruo; Onishi, Hidetoshi

    2008-01-01

    As for the influences of Chuetsu-Oki Earthquake on Kashiwazaki-Kariwa Nuclear Power Station, we can conclude that 'the safety function of the nuclear power station, that is, 'Shutdown', 'Cooling down' and 'Isolating' functioned as per designed even against earthquake beyond assumption, and fundamental nuclear safety could be assured'. Nevertheless, it is said that one of the causes that harmful rumor had spread was due to mass communication media. In the press reports on some nuclear power station when affected by an earthquake and on trouble in the nuclear power station in the future, we will propose that the publication should be really useful for habitants and citizens and be promoted in the positive and expected direction, in order not to make the same mistake as this time. JSME should aim at implement the above-mentioned proposal under cooperation with other academic societies and organizations. (author)

  17. Men exhibit greater fatigue resistance than women in alternated bench press and leg press exercises.

    Science.gov (United States)

    Monteiro, Estêvão R; Steele, James; Novaes, Jefferson S; Brown, Amanda F; Cavanaugh, Mark T; Vingren, Jakob L; Behm, David G

    2017-11-17

    The purpose of this study was to evaluate the influence of sex, exercise order, and rest interval on neuromuscular fatigue resistance for an alternated strength training sequence of bench press (BP) and leg press (LP) exercises. Twelve women and 16 men, both recreationally trained, performed four sessions in a random order: 1) BP followed by LP with three-minutes rest (BP+LP with rest), 2) LP followed by BP with three-minutes rest (LP+BP with rest), 3) BP followed by LP without rest interval (BP+LP no rest), and 4) LP followed by BP without rest interval (LP+BP no rest). Participants performed four sets with 100% of 10RM load to concentric failure with the goal of completing the maximum number of repetitions in both exercises. The fatigue index was analyzed from the first and last sets of each exercise bout. A main effect for sex showed that women exhibited 25.5% (p=0.001) and 24.5% (p=0.001) greater BP and LP fatigue than men respectively when performing 10RM. Men exhibited greater BP (p<0.0001; 34.1%) and LP (p<0.0001; 30.5%) fatigue resistance when a rest period was provided. Men did not show an exercise order effect for BP fatigue and exhibited greater (p=0.0003; 14.5%) LP fatigue resistance when BP was performed first. The present study demonstrated the greater fatigue resistance of men when performing 10RM BP and LP exercises. Since men tend to experience less fatigue with the second exercise in the exercise pairing, women's training programs should be adjusted to ensure they do not parallel men's resistance training programs.

  18. A superconducting solenoid and press for permanent magnet fabrication

    International Nuclear Information System (INIS)

    Mulcahy, T. M.; Hull, J. R.

    2002-01-01

    For the first time, a superconducting solenoid (SCM) was used to increase the remnant magnetization of sintered NdFeB permanent magnets (PMs). In particular, improved magnetic alignment of commercial-grade PM powder was achieved, as it was axial die pressed into 12.7-mm diameter cylindrical compacts in the 76.2-mm warm bore of a 9-T SCM. The press used to compact the powder is unique and was specifically designed for use with the SCM. Although the press was operated in the batch mode for this proof of concept study, its design is intended to enable automated production. In operation, a simple die and punch set made of nonmagnetic materials was filled with powder and loaded into a nonmagnetic press tube. The cantilevered press tube was inserted horizontally, on a carrier manually advanced along a track, into the SCM. The robustness of the mechanical components and the SCM, in its liquid helium dewar, were specifically designed to allow for insertion and extraction of the magnetic powder and compacts, while operating at 9 T. Compaction was achieved by pressing the punches between the closed end of the press tube and the hydraulic cylinder mounted on the opposite end. Improvements up to 10% in magnetization and 20% in energy products of the permanent magnets were obtained, as the alignment fields were increased above the 2-T maximum field of the electromagnets used in industry. Increases in magnetization of 3% are significant in the mature sintered magnet industry

  19. Jatropha press cake as organic fertilizer in lettuce cultivation

    Directory of Open Access Journals (Sweden)

    José R. Mantovani

    Full Text Available ABSTRACT In biodiesel production, vegetable press cake is obtained as waste, and a suitable destination for jatropha press cake would be the use in agriculture as organic fertilizer. This study aimed to evaluate the effect of jatropha press cake on soil fertility attributes and on lettuce production and accumulation of nutrients in the shoots. The experiment was conducted in pots in a greenhouse, in a randomized block design with eight treatments and five replicates. The treatments consisted of doses of jatropha press cake equivalent to 0, 0.5, 1.0, 2.0, 4.0, 8.0, 16.0 and 32.0 t ha-1. Portions of 5.5 dm3 of soil received limestone, phosphate fertilizer and the doses of jatropha press cake, and remained incubated for 30 days. After incubation, soil samples were collected, each pot received one lettuce seedling and the experiment was carried out for 45 days. The organic fertilization with jatropha press cake increased the contents of nutrients in the soil, especially K+, but caused increment in soil acidity and electrical conductivity. The use of jatropha press cake as organic fertilizer decreased lettuce production and accumulation of nutrients in the shoots.

  20. Mannes of Forging and Perspectives of Knuckle Joint Presses Modernization

    Directory of Open Access Journals (Sweden)

    A. A. Antsifirov

    2014-01-01

    Full Text Available The article raises an issue to enhance technological forging capabilities on the known knuckle joint presses. It provides an illustrated overview of main design types of presses with crank-knuckle, toggle-knuckle, and knuckle joint mechanisms. The article also shows the advantages of the modernization way and improvement just of the active press equipment in terms of quality-to-price ratio, for example, as compared to the similar new foreign press equipment.It gives an overview of features, which provide forging processes owing to kinetic energy accumulated with the moving parts of the known designs of the knuckle joint presses depending on the drive actuating mechanism. Focused attention is drawn to forging on the knuckle joint presses for a time of contact with a work piece to be comparable with the duration of the work piece deformation process on hydraulic forging hammers. This allows us to forge thin-wall products with process automation compared to the forging hammers.Analysis of accumulating processes of kinetic energy by the moving parts of the knuckle joint presses has shown that presses driven by hydraulic cylinders or two screw hydraulic cylinder are the most optimal for technological operations as evidenced by references to domestic and foreign invention certificates and patents. The article presents disadvantages of forging on presses with hydraulic or pneumatic drive. It is a dependence of the deformation force, caused, mainly, by a force of the drive cylinder. The article gives linear movement rate quantities of press moving members depending on the drives of the actuating mechanism. Based on the above analysis of the features to manufacture work pieces on the knuckle joint presses, the article gives the rationale for the relevance of forging in a short period of time, provided that the moving parts of the press accumulate the required kinetic energy. This can be achieved only through modernization and improvement of forging

  1. Press problem related to nuclear energy news reporting

    International Nuclear Information System (INIS)

    Arai, Mitsuo

    2008-01-01

    Since the event of Niigataken Chuetsu-oki Earthquake in 2007 and the subsequent press reports on damage of nuclear power station after it, a stance of media is being questioned. In order to clear this problem, basic organizational structure of the press related to nuclear energy news was analyzed. Local news department, social news department, science news department and economical news department involve in nuclear energy news the accordance with their own situations and concerns. This structure makes problem of nuclear energy news reporting complicated. Changing this system is required but very difficult. It is concluded that the press problem around nuclear energy news is strange. (author)

  2. Modeling steady-state dynamics of macromolecules in exponential-stretching flow using multiscale molecular-dynamics-multiparticle-collision simulations.

    Science.gov (United States)

    Ghatage, Dhairyasheel; Chatterji, Apratim

    2013-10-01

    We introduce a method to obtain steady-state uniaxial exponential-stretching flow of a fluid (akin to extensional flow) in the incompressible limit, which enables us to study the response of suspended macromolecules to the flow by computer simulations. The flow field in this flow is defined by v(x) = εx, where v(x) is the velocity of the fluid and ε is the stretch flow gradient. To eliminate the effect of confining boundaries, we produce the flow in a channel of uniform square cross section with periodic boundary conditions in directions perpendicular to the flow, but simultaneously maintain uniform density of fluid along the length of the tube. In experiments a perfect elongational flow is obtained only along the axis of symmetry in a four-roll geometry or a filament-stretching rheometer. We can reproduce flow conditions very similar to extensional flow near the axis of symmetry by exponential-stretching flow; we do this by adding the right amounts of fluid along the length of the flow in our simulations. The fluid particles added along the length of the tube are the same fluid particles which exit the channel due to the flow; thus mass conservation is maintained in our model by default. We also suggest a scheme for possible realization of exponential-stretching flow in experiments. To establish our method as a useful tool to study various soft matter systems in extensional flow, we embed (i) spherical colloids with excluded volume interactions (modeled by the Weeks-Chandler potential) as well as (ii) a bead-spring model of star polymers in the fluid to study their responses to the exponential-stretched flow and show that the responses of macromolecules in the two flows are very similar. We demonstrate that the variation of number density of the suspended colloids along the direction of flow is in tune with our expectations. We also conclude from our study of the deformation of star polymers with different numbers of arms f that the critical flow gradient ε

  3. Concept Design of Movable Beam of Hydraulic Press

    Directory of Open Access Journals (Sweden)

    Li Yancong

    2017-01-01

    Full Text Available The hydraulic press movable beam is one of the key components of the hydraulic press; its design quality impacts the accuracy of the workpiece that the press suppressed. In this paper, first, with maximum deflection and material strength as constraints, mechanical model of the movable beam is established; next, the concept design model of the moveable beam structure is established; the relationship among the force of the side cylinder, the thickness of the inclined plate, outer plate is established also. Taking movable beam of the 100MN type THP10-10000 isothermal forging hydraulic press as an example, the conceptual design result is given. This concept design method mentoned in the paper has general meaning and can apply to other similar product design.

  4. Fabrication and properties of hot pressed bismuth tungstate

    International Nuclear Information System (INIS)

    Streicher, W.L.

    1978-01-01

    Bi 2 WO 6 is a synthetic polar material that is a possible candidate for energy conversion and detection systems. Previous research on this material has been concerned with crystal growth and sintering characteristics of polycrystalline compacts. This study involves itself with the fabrication of polycrystalline compacts by hot pressing techniques. Densities approaching theoretical crystal density were achieved by hot pressing at 850 0 C for one hour with pressures exceeding 35 MPa. Before hot pressing, the sintering range was determined by high temperature dilatometry of unfired Bi 2 WO 6 ceramics. Hot pressed discs were characterized by scanning electron microscopy, differential scanning calorimetry, and x-ray diffraction. Electrical properties were determined by dc resistivity, capacitance, and conductance measurements, ac poling, dc poling, and current-voltage measurements

  5. Pleurotus pulmonarius cultivation on amended palm press fibre waste

    African Journals Online (AJOL)

    Bola

    2015-05-13

    May 13, 2015 ... Seven different substrates (A to G) were prepared from saw dust, palm press ... can grow in a wide range of soil types with relatively low ..... documented to include; cotton waste, sugar cane ..... Canada wood ash sources. Can.

  6. Poland's Press and Broadcasting Under the Gierek Regime

    Science.gov (United States)

    Shanor, Donald R.

    1974-01-01

    Reports that the Polish press and broadcasting have been carrying more news and less propaganda since the 1970 Baltic upheavel and that the Polish media are generally allowed more freedom than media in other Communist nations. (RB)

  7. Press releases — the new trend in science communication

    DEFF Research Database (Denmark)

    Autzen, Charlotte

    2014-01-01

    Scientific institutions have for a long time known the importance of framing and owning stories about science They also know the effective way of communicating science in a press release This is part of the institution’s public relations. Enhanced competition among research institutions has led...... to a buildup of communicative competences and professionalization of public relations inside the institutions and the press release has become an integrated part of science communication from these institutions. Changing working conditions in the media, where fewer people have to publish more, have made press...... releases from trustworthy scientific institutions into free and easily copied content for the editors. In this commentary I investigate and discuss the communicative ecosystem of the university press release. I especially take a close look at the role of the critical and independent science journalist...

  8. Cars & Censorship: How Advertising Pressure Can Corrupt a Free Press.

    Science.gov (United States)

    Collins, Ronald K. L.

    1992-01-01

    Discusses "private censorship" as it relates to car dealers and television advertising. Defines "private censorship" as that which occurs when a broadcaster suppresses or alters a news story that affects commercial clients (advertisers). Makes recommendations for a freer press. (JOW)

  9. Modelling of powder die compaction for press cycle optimization

    Directory of Open Access Journals (Sweden)

    Bayle Jean-Philippe

    2016-01-01

    Full Text Available A new electromechanical press for fuel pellet manufacturing was built last year in partnership between CEA-Marcoule and ChampalleAlcen. This press was developed to shape pellets in a hot cell via remote handling. It has been qualified to show its robustness and to optimize the compaction cycle, thus obtaining a better sintered pellet profile and limiting damage. We will show you how 400 annular pellets have been produced with good geometry's parameters, based on press settings management. These results are according to a good phenomenological pressing knowledge with Finite Element Modeling calculation. Therefore, during die pressing, a modification in the punch displacement sequence induces fluctuation in the axial distribution of frictional forces. The green pellet stress and density gradients are based on these frictional forces between powder and tool, and between grains in the powder, influencing the shape of the pellet after sintering. The pellet shape and diameter tolerances must be minimized to avoid the need for grinding operations. To find the best parameters for the press settings, which enable optimization, FEM calculations were used and different compaction models compared to give the best calculation/physical trial comparisons. These simulations were then used to predict the impact of different parameters when there is a change in the type of powder and the pellet size, or when the behavior of the press changes during the compaction time. In 2016, it is planned to set up the press in a glove box for UO2 manufacturing qualification based on our simulation methodology, before actual hot cell trials in the future.

  10. Dynamic Multiaxial Response of a Hot-Pressed Aluminum Nitride

    Science.gov (United States)

    2012-01-05

    Hutchinson, Adv. Appl . Mech. 29 (1992). [34] H. Ming-Yuan, J.W. Hutchinson, Int. J. Solids Struct. 25 (1989) 1053. [35] J. Salem , L. Ghosn, Int. J...Dynamic Multiaxial Response of a Hot- Pressed Aluminum Nitride by Guangli Hu, C. Q. Chen, K. T. Ramesh, and J. W. McCauley ARL-RP-0487...Laboratory Aberdeen Proving Ground, MD 21005-5066 ARL-RP-0487 June 2014 Dynamic Multiaxial Response of a Hot- Pressed Aluminum Nitride

  11. Speech freedom and press freedom in human security in Rwanda

    OpenAIRE

    Niyonzima, Oswald

    2014-01-01

    Treball Final de Màster Universitari Internacional en Estudis de Pau, Conflictes i Desenvolupament. Codi: SAA074. Curs: 2013/2014 Freedom of speech and press freedom are key foundations of all human rights as stipulated in human rights declaration of 1948. Denying people the right to free speech is keeping them away from what is happening in this world, thus, hindering them from participating in decision making. While speech freedom and press freedom are key tools to measure if a country ...

  12. PRESS: A Novel Framework of Trajectory Compression in Road Networks

    OpenAIRE

    Song, Renchu; Sun, Weiwei; Zheng, Baihua; Zheng, Yu

    2014-01-01

    Location data becomes more and more important. In this paper, we focus on the trajectory data, and propose a new framework, namely PRESS (Paralleled Road-Network-Based Trajectory Compression), to effectively compress trajectory data under road network constraints. Different from existing work, PRESS proposes a novel representation for trajectories to separate the spatial representation of a trajectory from the temporal representation, and proposes a Hybrid Spatial Compression (HSC) algorithm ...

  13. Corporate social responsibility's discourse in lithuanian business press

    OpenAIRE

    Marčenkovas, Marius

    2014-01-01

    The object of this master work is corporate social responsibility's (CSR) discourse. The purpose of this work is to analyze how Lithuanian business press presents CSR topic. The main tasks to reach this purpose are: overview and compare CSR definitions; analyze media impact to CSR; analyze and summarize CSR discourse in Lithuanian business press. Literature analysis, synthesis and comparative methods were used to drawn conclusions. After the literature analysis of such scientists as Ph. Kotle...

  14. Resident-performed Ex-PRESS shunt implantation versus trabeculectomy.

    Science.gov (United States)

    Seider, Michael I; Rofagha, Soraya; Lin, Shan C; Stamper, Robert L

    2012-09-01

    To compare outcomes between resident-performed trabeculectomy and Ex-PRESS shunt implantation. A consecutive cohort of 36 Ex-PRESS shunt implantations and 57 trabeculectomies (1 eye/patient) performed by resident surgeons in their third year of ophthalmic training at the University of California, San Francisco and at the San Francisco Veterans Administration Hospital, under the supervision of a single glaucoma fellowship-trained surgeon were included in this study. Eyes with PRESS shunt groups at all follow-up points. On average, the Ex-PRESS shunt group required significantly less ocular antihypertensive medication to control IOP at 3 months postoperative (P=0.01), but no difference was found at 6 months or 1 year (all, P≥0.28). A larger proportion of Ex-PRESS shunt patients had good IOP control without medication at 3 (P=0.057) and 6 months (P=0.076) postoperatively. No difference was found in the rates of sight-threatening complications between groups (all, P≥0.22). In the hands of ophthalmology residents in their third year of training, the trabeculectomy and Ex-PRESS shunt implantation procedures perform comparably in terms of postoperative IOP control, reduction in patient dependence on ocular antihypertensive medications, and risk of complication in our population.

  15. The role of the extracellular matrix in tissue distribution of macromolecules in normal and pathological tissues: potential therapeutic consequences.

    Science.gov (United States)

    Wiig, Helge; Gyenge, Christina; Iversen, Per Ole; Gullberg, Donald; Tenstad, Olav

    2008-05-01

    The interstitial space is a dynamic microenvironment that consists of interstitial fluid and structural molecules of the extracellular matrix, such as glycosaminoglycans (hyaluronan and proteoglycans) and collagen. Macromolecules can distribute in the interstitium only in those spaces unoccupied by structural components, a phenomenon called interstitial exclusion. The exclusion phenomenon has direct consequences for plasma volume regulation. Early studies have assigned a major role to collagen as an excluding agent that accounts for the sterical (geometrical) exclusion. More recently, it has been shown that the contribution of negatively charged glycosaminoglycans might also be significant, resulting in an additional electrostatical exclusion effect. This charge effect may be of importance for drug uptake and suggests that either the glycosaminoglycans or the net charge of macromolecular substances to be delivered may be targeted to increase the available volume and uptake of macromolecular therapeutic agents in tumor tissue. Here, we provide an overview of the structural components of the interstitium and discuss the importance the sterical and electrostatical components have on the dynamics of transcapillary fluid exchange.

  16. Analysis of Mammalian Cell Proliferation and Macromolecule Synthesis Using Deuterated Water and Gas Chromatography-Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Victoria C. Foletta

    2016-10-01

    Full Text Available Deuterated water (2H2O, a stable isotopic tracer, provides a convenient and reliable way to label multiple cellular biomass components (macromolecules, thus permitting the calculation of their synthesis rates. Here, we have combined 2H2O labelling, GC-MS analysis and a novel cell fractionation method to extract multiple biomass components (DNA, protein and lipids from the one biological sample, thus permitting the simultaneous measurement of DNA (cell proliferation, protein and lipid synthesis rates. We have used this approach to characterize the turnover rates and metabolism of a panel of mammalian cells in vitro (muscle C2C12 and colon cancer cell lines. Our data show that in actively-proliferating cells, biomass synthesis rates are strongly linked to the rate of cell division. Furthermore, in both proliferating and non-proliferating cells, it is the lipid pool that undergoes the most rapid turnover when compared to DNA and protein. Finally, our data in human colon cancer cell lines reveal a marked heterogeneity in the reliance on the de novo lipogenic pathway, with the cells being dependent on both ‘self-made’ and exogenously-derived fatty acid.

  17. Evanescent wave cavity ring-down spectroscopy (EW-CRDS) as a probe of macromolecule adsorption kinetics at functionalized interfaces.

    Science.gov (United States)

    O'Connell, Michael A; de Cuendias, Anne; Gayet, Florence; Shirley, Ian M; Mackenzie, Stuart R; Haddleton, David M; Unwin, Patrick R

    2012-05-01

    Evanescent wave cavity ring-down spectroscopy (EW-CRDS) has been employed to study the interfacial adsorption kinetics of coumarin-tagged macromolecules onto a range of functionalized planar surfaces. Such studies are valuable in designing polymers for complex systems where the degree of interaction between the polymer and surface needs to be tailored. Three tagged synthetic polymers with different functionalities are examined: poly(acrylic acid) (PAA), poly(3-sulfopropyl methacrylate, potassium salt) (PSPMA), and a mannose-modified glycopolymer. Adsorption transients at the silica/water interface are found to be characteristic for each polymer, and kinetics are deduced from the initial rates. The chemistry of the adsorption interfaces has been varied by, first, manipulation of silica surface chemistry via the bulk pH, followed by surfaces modified by poly(L-glutamic acid) (PGA) and cellulose, giving five chemically different surfaces. Complementary atomic force microscopy (AFM) imaging has been used for additional surface characterization of adsorbed layers and functionalized interfaces to allow adsorption rates to be interpreted more fully. Adsorption rates for PSPMA and the glycopolymer are seen to be highly surface sensitive, with significantly higher rates on cellulose-modified surfaces, whereas PAA shows a much smaller rate dependence on the nature of the adsorption surface.

  18. Structural properties of the intrinsically disordered, multiple calcium ion-binding otolith matrix macromolecule-64 (OMM-64).

    Science.gov (United States)

    Poznar, Monika; Hołubowicz, Rafał; Wojtas, Magdalena; Gapiński, Jacek; Banachowicz, Ewa; Patkowski, Adam; Ożyhar, Andrzej; Dobryszycki, Piotr

    2017-11-01

    Fish otoliths are calcium carbonate biominerals that are involved in hearing and balance sensing. An organic matrix plays a crucial role in their formation. Otolith matrix macromolecule-64 (OMM-64) is a highly acidic, calcium-binding protein (CBP) found in rainbow trout otoliths. It is a component of high-molecular-weight aggregates, which influence the size, shape and polymorph of calcium carbonate in vitro. In this study, a protocol for the efficient expression and purification of OMM-64 was developed. For the first time, the complete structural characteristics of OMM-64 were described. Various biophysical methods were combined to show that OMM-64 occurs as an intrinsically disordered monomer. Under denaturing conditions (pH, temperature) OMM-64 exhibits folding propensity. It was determined that OMM-64 binds approximately 61 calcium ions with millimolar affinity. The folding-unfolding experiments showed that calcium ions induced the collapse of OMM-64. The effect of other counter ions present in trout endolymph on OMM-64 conformational changes was studied. The significance of disordered properties of OMM-64 and the possible function of this protein is discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. QM/MM hybrid calculation of biological macromolecules using a new interface program connecting QM and MM engines

    Energy Technology Data Exchange (ETDEWEB)

    Hagiwara, Yohsuke; Tateno, Masaru [Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba Science City, Ibaraki 305-8571 (Japan); Ohta, Takehiro [Center for Computational Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba Science City, Ibaraki 305-8577 (Japan)], E-mail: tateno@ccs.tsukuba.ac.jp

    2009-02-11

    An interface program connecting a quantum mechanics (QM) calculation engine, GAMESS, and a molecular mechanics (MM) calculation engine, AMBER, has been developed for QM/MM hybrid calculations. A protein-DNA complex is used as a test system to investigate the following two types of QM/MM schemes. In a 'subtractive' scheme, electrostatic interactions between QM/MM regions are truncated in QM calculations; in an 'additive' scheme, long-range electrostatic interactions within a cut-off distance from QM regions are introduced into one-electron integration terms of a QM Hamiltonian. In these calculations, 338 atoms are assigned as QM atoms using Hartree-Fock (HF)/density functional theory (DFT) hybrid all-electron calculations. By comparing the results of the additive and subtractive schemes, it is found that electronic structures are perturbed significantly by the introduction of MM partial charges surrounding QM regions, suggesting that biological processes occurring in functional sites are modulated by the surrounding structures. This also indicates that the effects of long-range electrostatic interactions involved in the QM Hamiltonian are crucial for accurate descriptions of electronic structures of biological macromolecules.

  20. Magnetization transfer from macromolecules to water protons in murine dental tissues as revealed by 500 MHz 1H-NMR

    International Nuclear Information System (INIS)

    Nakamura, Koji; Era, Seiichi; Nagai, Naoki; Sogami, Masaru; Takasaki, Akihiko; Kato, Kazuo.

    1997-01-01

    Although much is known about magnetization transfer phenomena in biological soft tissues, little is known about those in hard tissues. Using a 500 MHz 1 H-NMR spectrometer, we studied the spin-lattice relaxation time (T 1 (H 2 O)) and the intermolecular cross-relaxation times (T IS (H 2 O)) from irradiated macromolecular protons to observed water protons in murine lower incisors (hard tissue) and compared with those in murine lens tissue (soft tissue). Mean values for the water content (%) of murine lower incisors and lens tissue were 16.02±2.39 (n=14) and 67.20±4.60 (n=15), respectively. These findings were consistent with the large different in water content between soft tissues and hard tissues. T IS (H 2 O) values obtained by f 2 -irradiation at 7.13 or -4.00 ppm showed no significant difference between lower incisors and lens tissue. Plots of 1/T IS (H 2 O) values vs. tissue dry weight (W(%)) for lower incisor tissue approximated a straight line with slope approximately equal for that obtained for lens tissue. These results suggest that the state of water in hard tissue may be similar to that in soft tissues, in spite of the significant difference in water content. Thus, saturation transfer NMR techniques such as measurement of T IS (H 2 O) values may be applicable to the study of water-macromolecule interactions in both biological soft and hard tissues. (author)

  1. A new highly adaptable design of shear-flow device for orientation of macromolecules for Linear Dichroism (LD) measurement

    KAUST Repository

    Lundahl, P. Johan; Kitts, Catherine C.; Nordé n, Bengt

    2011-01-01

    This article presents a new design of flow-orientation device for the study of bio-macromolecules, including DNA and protein complexes, as well as aggregates such as amyloid fibrils and liposome membranes, using Linear Dichroism (LD) spectroscopy. The design provides a number of technical advantages that should make the device inexpensive to manufacture, easier to use and more reliable than existing techniques. The degree of orientation achieved is of the same order of magnitude as that of the commonly used concentric cylinders Couette flow cell, however, since the device exploits a set of flat strain-free quartz plates, a number of problems associated with refraction and birefringence of light are eliminated, increasing the sensitivity and accuracy of measurement. The device provides similar shear rates to those of the Couette cell but is superior in that the shear rate is constant across the gap. Other major advantages of the design is the possibility to change parts and vary sample volume and path length easily and at a low cost. © 2011 The Royal Society of Chemistry.

  2. Nanometer-scale structure of alkali-soluble bio-macromolecules of maize plant residues explains their recalcitrance in soil.

    Science.gov (United States)

    Adani, Fabrizio; Salati, Silvia; Spagnol, Manuela; Tambone, Fulvia; Genevini, Pierluigi; Pilu, Roberto; Nierop, Klaas G J

    2009-07-01

    The quantity and quality of plant litter in the soil play an important role in the soil organic matter balance. Besides other pedo-climatic aspects, the content of recalcitrant molecules of plant residues and their chemical composition play a major role in the preservation of plant residues. In this study, we report that intrinsically resistant alkali-soluble bio-macromolecules extracted from maize plant (plant-humic acid) (plant-HA) contribute directly to the soil organic matter (OM) by its addition and conservation in the soil. Furthermore, we also observed that a high syringyl/guaiacyl (S/G) ratio in the lignin residues comprising the plant tissue, which modifies the microscopic structure of the alkali-soluble plant biopolymers, enhances their recalcitrance because of lower accessibility of molecules to degrading enzymes. These results are in agreement with a recent study, which showed that the humic substance of soil consists of a mixture of identifiable biopolymers obtained directly from plant tissues that are added annually by maize plant residues.

  3. Oxidative damage to biological macromolecules in Prague bus drivers and garagemen: impact of air pollution and genetic polymorphisms.

    Science.gov (United States)

    Bagryantseva, Yana; Novotna, Bozena; Rossner, Pavel; Chvatalova, Irena; Milcova, Alena; Svecova, Vlasta; Lnenickova, Zdena; Solansky, Ivo; Sram, Radim J

    2010-11-10

    DNA integrity was investigated in the lymphocytes of 50 bus drivers, 20 garagemen and 50 controls using the comet assay with excision repair enzymes. In parallel, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 15-F(2t)-isoprostane levels in the urine and protein carbonyl levels in the plasma were assessed as markers of oxidative damage to DNA, lipids and proteins. Exposure to carcinogenic polycyclic aromatic hydrocarbons (cPAHs) and volatile compounds was measured by personal samplers for 48 and 24h, respectively, before the collection of biological specimens. Both exposed groups exhibited a higher levels of DNA instability and oxidative damage to biological macromolecules than the controls. The incidence of oxidized lesions in lymphocyte DNA, but not the urinary levels of 8-oxodG, correlated with exposure to benzene and triglycerides increased this damage. Oxidative damage to lipids and proteins was associated with exposure to cPAHs and the lipid peroxidation levels positively correlated with age and LDL cholesterol, and negatively with vitamin C. The carriers of at least one variant hOGG1 (Cys) allele tended to higher oxidative damage to lymphocyte DNA than those with the wild genotype, while XPD23 (Gln/Gln) homozygotes were more susceptible to the induction of DNA strand breaks. In contrast, GSTM1 null variant seemed to protect DNA integrity. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  4. Volatile organic compound emissions during hot-pressing of southern pine particleboard : panel size effects and trade-off between press time and temperature

    Science.gov (United States)

    Wenlong Wang; Douglas J. Gardner; Melissa G.D. Baumann

    2002-01-01

    In previous research, it was shown that decreasing either press temperature or press time generally resulted in decreased volatile organic compound (VOC) emissions during the hot-pressing of southern pine particleboard. However, because it is impossible to reduce both pressing time and temperature while maintaining panel physical and mechanical properties, this study...

  5. Comparison of Myoelectric Activity of a Selection of Upper Extremity Muscles while Doing Bench Press in Two Training Methods of TRX and Barbell Bench Press

    Directory of Open Access Journals (Sweden)

    Ahmad Reza Zibaei

    2016-12-01

    Conclusion: Considering these results it can be maintained that TRX bench press resistance training can be an alternative and effective practice for barbell bench press because, given the results, it can be appreciated that TRX bench press, dips low in the trunk, can lead to muscle activity close to the level of muscle activity during the barbell bench press drill.

  6. A comparative study between spiral-filter press and belt press implemented in a cloudy apple juice production process.

    Science.gov (United States)

    De Paepe, Domien; Coudijzer, Katleen; Noten, Bart; Valkenborg, Dirk; Servaes, Kelly; De Loose, Marc; Diels, Ludo; Voorspoels, Stefan; Van Droogenbroeck, Bart

    2015-04-15

    In this study, advantages and disadvantages of the innovative, low-oxygen spiral-filter press system were studied in comparison with the belt press, commonly applied in small and medium size enterprises for the production of cloudy apple juice. On the basis of equivalent throughput, a higher juice yield could be achieved with spiral-filter press. Also a more turbid juice with a higher content of suspended solids could be produced. The avoidance of enzymatic browning during juice extraction led to an attractive yellowish juice with an elevated phenolic content. Moreover, it was found that juice produced with spiral-filter press demonstrates a higher retention of phenolic compounds during the downstream processing steps and storage. The results demonstrates the advantage of the use of a spiral-filter press in comparison with belt press in the production of a high quality cloudy apple juice rich in phenolic compounds, without the use of oxidation inhibiting additives. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. Thermochemolysis: A New Sample Preparation Approach for the Detection of Organic Components of Complex Macromolecules in Mars Rocks via Gas Chromatography Mass Spectrometry in SAM on MSL

    Science.gov (United States)

    Eugenbrode, J.; Glavin, D.; Dworkin, J.; Conrad, P.; Mahaffy, P.

    2011-01-01

    Organic chemicals, when present in extraterrestrial samples, afford precious insight into past and modern conditions elsewhere in the Solar System . No single technology identifies all molecular components because naturally occurring molecules have different chemistries (e.g., polar vs. non-polar, low to high molecular weight) and interface with the ambient sample chemistry in a variety of modes (i.e., organics may be bonded, absorbed or trapped by minerals, liquids, gases, or other organics). More than 90% of organic matter in most natural samples on Earth and in meteorites is composed of complex macromolecules (e.g. biopolymers, complex biomolecules, humic substances, kerogen) because the processes that tend to break down organic molecules also tend towards complexation of the more recalcitrant components. Thus, methodologies that tap the molecular information contained within macromolecules may be critical to detecting extraterrestrial organic matter and assessing the sources and processes influencing its nature.

  8. Rate Measurements of the Hydrolysis of Complex Organic Macromolecules in Cold Aqueous Solutions: Implications for Prebiotic Chemistry on the Early Earth and Titan

    Science.gov (United States)

    Neish, C. D.; Somogyi, Á.; Imanaka, H .; Lunine, J. I.; Smith, M. A.

    2008-04-01

    Organic macromolecules (``complex tholins'') were synthesized from a 0.95 N2 / 0.05 CH4 atmosphere in a high-voltage AC flow discharge reactor. When placed in liquid water, specific water soluble compounds in the macromolecules demonstrated Arrhenius type first order kinetics between 273 and 313 K and produced oxygenated organic species with activation energies in the range of ~60 +/- 10 kJ mol-1. These reactions displayed half lives between 0.3 and 17 days at 273 K. Oxygen incorporation into such materials-a necessary step toward the formation of biological molecules-is therefore fast compared to processes that occur on geologic timescales, which include the freezing of impact melt pools and possible cryovolcanic sites on Saturn's organic-rich moon Titan.

  9. Elbow joint fatigue and bench-press training.

    Science.gov (United States)

    Huang, Yen-Po; Chou, You-Li; Chen, Feng-Chun; Wang, Rong-Tyai; Huang, Ming-Jer; Chou, Paul Pei-Hsi

    2014-01-01

    Bench-press exercises are among the most common form of training exercise for the upper extremity because they yield a notable improvement in both muscle strength and muscle endurance. The literature contains various investigations into the effects of different bench-press positions on the degree of muscle activation. However, the effects of fatigue on the muscular performance and kinetics of the elbow joint are not understood fully. To investigate the effects of fatigue on the kinetics and myodynamic performance of the elbow joint in bench-press training. Controlled laboratory study. Motion research laboratory. A total of 18 physically healthy male students (age = 19.6 ± 0.8 years, height = 168.7 ± 5.5 cm, mass = 69.6 ± 8.6 kg) participated in the investigation. All participants were right-hand dominant, and none had a history of upper extremity injuries or disorders. Participants performed bench-press training until fatigued. Maximal possible number of repetitions, cycle time, myodynamic decline rate, elbow-joint force, and elbow-joint moment. We observed a difference in cycle time in the initial (2.1 ± 0.42 seconds) and fatigue (2.58 ± 0.46 seconds) stages of the bench-press exercise (P = .04). As the participants fatigued, we observed an increase in the medial-lateral force (P = .03) and internal-external moment (P ≤ .04) acting on the elbow joint. Moreover, a reduction in the elbow muscle strength was observed in the elbow extension-flexion (P ≤ .003) and forearm supination-pronation (P ≤ .001) conditions. The results suggest that performing bench-press exercises to the point of fatigue increases elbow-joint loading and may further increase the risk of injury. Therefore, when clinicians design bench-press exercise regimens for general athletic training, muscle strengthening, or physical rehabilitation, they should control carefully the maximal number of repetitions.

  10. Movement Features Which Describe the Flat Bench Press

    Directory of Open Access Journals (Sweden)

    Król Henryk

    2017-06-01

    Full Text Available Introduction. In sport technique studies, motion features can be useful as they have a certain defined measure [1]. In this work, we examined the following three features: the structure of the movement (all the characteristics of the movement, the fluency of the movement, and the rhythm of the movement. The aim of the study was to determine the usefulness of the selected movement features in the evaluation of the flat bench press. The protocol of the study included a flat bench press with free weights and a “touch-and-go” technique. Material and methods. The study involved twenty healthy men; however, only two were selected for analysis. The first subject was a 25-year-old powerlifter (body mass = 95 kg; body height = 182 cm; 1-RM in flat bench press = 145 kg. The second one was a 25-year-old bodybuilder (body mass = 77 kg; body height = 175 cm; 1-RM in flat bench press = 100 kg. The subjects performed consecutive sets of a single repetition of flat bench pressing with an increasing load (70, 80, 90, and 100% 1-RM, with the anticipated maximum weight, until the completion of one repetition maximum. Multidimensional movement analysis was made with the measuring system Smart-E (BTS, Italy, which consisted of six infrared cameras (120 Hz and a wireless module to measure muscle bioelectric activity (Pocket EMG. Results. It was demonstrated that the internal structure of the bench press performed by the bodybuilder and the powerlifter was different. As the time-history of barbell kinematics (the acceleration-time curve showed, with increased loading of the barbell, the rhythm of the flat bench press changed, and the fluidity of the movement worsened.

  11. Freedom of the Press In the Scope of Human Rights

    Directory of Open Access Journals (Sweden)

    Sri Ayu Astuti

    2014-01-01

    Full Text Available Freedom of expression and press freedom is the embodiment of the recognition of human rights. Freedom of expression is also the existence of press to disclose the news with honesty and do not get a pressure to deliver the news to the public space, which in news production is known as a work of journalism. Now the  press has gained freedom of expression in the news production process which is guaranteed in the state constitution. Although Article 28 of the Constitution of the Republic of Indonesia 1945 does not point directly at the press, However, Article 28 F emphasis on processing and storage as well as ownership, excavations to information. It also contains provisions on the freedom of expression of others, which should be valued and respected. It shows equality for everyone in his position before the law in accordance with Article 27 1945 Constitution, which emphasizes the recognition of constitutional rights that belong to every person in the state of law in the Republic of Indonesia. Thus the press, which have freedom of expression in the writings of journalistic works are required to be responsible for the published news. So as not to face the legal issues and criminalization, then press should perform tasks and functions to enforce ethics as the precautionary principle when processing the news and broadcast it to the public space, as well as upholding human rights. How To Cite: Astuti, S. (2014. Freedom of the Press In the Scope of Human Rights. Rechtsidee, 1(1, 101-118. doi:http://dx.doi.org/10.21070/jihr.v1i1.96

  12. Role of endothelial permeability hotspots and endothelial mitosis in determining age-related patterns of macromolecule uptake by the rabbit aortic wall near branch points.

    Science.gov (United States)

    Chooi, K Yean; Comerford, Andrew; Cremers, Stephanie J; Weinberg, Peter D

    2016-07-01

    Transport of macromolecules between plasma and the arterial wall plays a key role in atherogenesis. Scattered hotspots of elevated endothelial permeability to macromolecules occur in the aorta; a fraction of them are associated with dividing cells. Hotspots occur particularly frequently downstream of branch points, where lesions develop in young rabbits and children. However, the pattern of lesions varies with age, and can be explained by similar variation in the pattern of macromolecule uptake. We investigated whether patterns of hotspots and mitosis also change with age. Evans' Blue dye-labeled albumin was injected intravenously into immature or mature rabbits and its subsequent distribution in the aortic wall around intercostal branch ostia examined by confocal microscopy and automated image analysis. Mitosis was detected by immunofluorescence after adding 5-bromo-2-deoxiuridine to drinking water. Hotspots were most frequent downstream of branches in immature rabbits, but a novel distribution was observed in mature rabbits. Neither pattern was explained by mitosis. Hotspot uptake correlated spatially with the much greater non-hotspot uptake (p hotspots were considered. The pattern of hotspots changes with age. The data are consistent with there being a continuum of local permeabilities rather than two distinct mechanisms. The distribution of the dye, which binds to elastin and collagen, was similar to that of non-binding tracers and to lesions apart from a paucity at the lateral margins of branches that can be explained by lower levels of fibrous proteins in those regions. Copyright © 2016. Published by Elsevier Ireland Ltd.

  13. Engaging and Supporting a University Press Scholarly Community

    Directory of Open Access Journals (Sweden)

    Megan Taylor

    2018-03-01

    Full Text Available In this paper we explore how the development of The University of Huddersfield Press, a publisher of open access scholarly journals and monographs, has enabled the sharing of research with a wider online audience. We situate the development of the Press within a wider research environment and growing community of New University Presses (NUPs where there is an increasing demand for demonstrating research impact, which drives the need for improved analysis and reporting of impact data, a task that often falls within the remit of library and academic support services. We detail the benefits of the University Press Manager role in terms of ensuring professional service that delivers consistency and sustainability. We go on to outline the experiences of engaging with different online spaces and detail the extensive support for student authors. We argue that in order for the Press to support building a strong and engaged scholarly community and provide new spaces for emerging research, continued investment in both platform development and infrastructure is required.

  14. One-pot synthesis of star-shaped macromolecules containing polyglycidol and poly(ethylene oxide) arms.

    Science.gov (United States)

    Lapienis, Grzegorz; Penczek, Stanislaw

    2005-01-01

    Synthesis of fully hydrophilic star-shaped macromolecules with different kinds of arms (A(x)B(y)C(z)) based on polyglycidol (PGL, A(x)) and poly(ethylene oxide) (PEO, C(z)) arms and diepoxy compounds (diglycidyl ethers of ethylene glycol (DGEG) or neopentyl glycol (DGNG) in the core, B(y)) forming the core is described. Precursors of arms were prepared by polymerization of glycidol with protected -OH groups. The first-generation stars were formed in the series of consecutive-parallel reactions of arms A(x) with diepoxy compounds (B). These first-generation stars (A(x)B(y)), having approximately O-, Mt+ groups on the cores, were used as multianionic initiators for the second generation of arms (C(z)) built by polymerization of ethylene oxide. The products with M(n) up to 10(5) and having up to approximately 40 arms were obtained. The number of arms (f) was determined by direct measurements of M(n) of the first-generation stars (M(n) of arms A(x) is known), compared with f calculated from the branching index g, determined from R(g) measured with size-exclusion chromatography (SEC) triple detection with TriSEC software. The progress of the star formation was monitored by 1H NMR and SEC. These novel water-soluble stars, having a large number of hydroxyl groups, both at the ends of PEO arms as well as within the PGL arms, can be functionalized and further used for attaching compounds of interest. This approach opens, therefore, a new way of "multiPEGylation".

  15. S-protected thiolated chitosan for oral delivery of hydrophilic macromolecules: evaluation of permeation enhancing and efflux pump inhibitory properties.

    Science.gov (United States)

    Dünnhaupt, Sarah; Barthelmes, Jan; Rahmat, Deni; Leithner, Katharina; Thurner, Clemens C; Friedl, Heike; Bernkop-Schnürch, Andreas

    2012-05-07

    The objective of this study was the investigation of permeation enhancing and P-glycoprotein (P-gp) inhibition effects of a novel thiolated chitosan, the so-named S-protected thiolated chitosan. Mediated by a carbodiimide, increasing amounts of thioglycolic acid (TGA) were covalently bound to chitosan (CS) in the first step of modification. In the second step, these thiol groups of thiolated chitosan were protected by disulfide bond formation with the thiolated aromatic residue 6-mercaptonicotinamide (6-MNA). Mucoadhesive properties of all conjugates were evaluated in vitro on porcine intestinal mucosa based on tensile strength investigations. Permeation enhancing effects were evaluated ex vivo using rat intestinal mucosa and in vitro via Caco-2 cells using the hydrophilic macromolecule FD(4) as the model drug. Caco-2 cells were further used to show P-gp inhibition effects by using Rho-123 as P-gp substrate. Apparent permeability coefficients (P(app)) were calculated and compared to values obtained from each buffer control. Three different thiolated chitosans were generated in the first step of modification, which displayed increasing amounts of covalently attached free thiol groups on the polymer backbone. In the second modification step, more than 50% of these free thiol groups were covalently linked with 6-MNA. Within 3 h of permeation studies on excised rat intestine, P(app) values of all S-protected chitosans were at least 1.3-fold higher compared to those of corresponding thiomers and more than twice as high as that of unmodified chitosan. Additional permeation studies on Caco-2 cells confirmed these results. Because of the chemical modification and higher amount of reactive thiol groups, all S-protected thiolated chitosans exhibit at least 1.4-fold pronounced P-gp inhibition effects in contrast to their corresponding thiomers. These features approve S-protected thiolated chitosan as a promising excipient for various drug delivery systems providing improved

  16. Physiochemical and spectroscopic behavior of actinides and lanthanides in solution, their sorption on minerals and their compounds formed with macromolecules

    International Nuclear Information System (INIS)

    Jimenez R, M.

    2010-01-01

    From the chemical view point, the light actinides has been those most studied; particularly the uranium, because is the primordial component of the nuclear reactors. The chemical behavior of these elements is not completely defined, since they can behave as transition metals or metals of internal transition, as they are the lanthanides. The actinides are radioactive; between them they are emitters of radiation alpha, highly toxic, of live half long and some very long, and artificial elements. For all this, to know them sometimes is preferable to use their chemical similarity with the lanthanides and to study these. In particular, the migration of emitters of radiation alpha to the environment has been studied taking as model the uranium. It is necessary to mention that actinides and lanthanides elements are in the radioactive wastes of the nuclear reactors. In the Chemistry Department of the Instituto Nacional de Investigaciones Nucleares (ININ) the researches about the actinides and lanthanides began in 1983 and, between that year and 1995 several works were published in this field. In 1993 the topic was proposed as a Department project and from then around of 13 institutional projects and managerial activity have been developed, besides 4 projects approved by the National Council of Science and Technology. The objective of the projects already developed and of the current they have been contributing knowledge for the understanding of the chemical behavior of the lanthanides and actinides, as much in solution as in the solid state, their behavior in the environment and the chemistry of their complexes with recurrent and lineal macromolecules. (Author)

  17. Zinc ions regulate opening of tight junction favouring efflux of macromolecules via the GSK3β/snail-mediated pathway.

    Science.gov (United States)

    Xiao, Ruyue; Yuan, Lan; He, Weijiang; Yang, Xiaoda

    2018-01-24

    Zinc is an essential trace element presenting in particularly high concentration in the brain. In some regions, e.g. lateral amygdala, subiculum and hippocampus, rapidly-exchangeable zinc may transiently reach even up to 600 μM. To explore the possible roles of high-concentration Zn 2+ in regulating the blood-brain barrier (BBB), we investigated the effects of Zn 2+ on the functions and structures of the tight junction (TJ) with an in vitro model of a Madin-Darby canine kidney (MDCK) cell monolayer. The experimental results indicated that high concentrations (>200 μM) of Zn 2+ can affect the TJ integrity in a polarized manner. Basolateral addition of Zn 2+ led to reversible TJ opening with pore paths of r ∼ 2 nm or more depending on Zn 2+ concentration. The efflux/influx ratios of different sized probes were found to be ∼4.6 for FD4 (M W 4000) and ∼1.8 for Eu-DTPA (M W 560), suggesting that the Zn 2+ -induced paracelluar channels favour efflux especially for macromolecules. Further mechanistic studies revealed that the elevated intracellular Zn 2+ taken from the basolateral side can increase phosphorylation of glycogen synthase kinase (GSK) 3β, primarily due to the inhibition of calcineurin (CaN), thus resulting in the elevation of the snail transcriptional repressors. Subsequently, Zn 2+ can cause the down-regulation of claudin-1, breakage of occludin and ZO-1 rings, and collapse of basolateral F-actin structures. These overall factors result in the formation of a trumpet-like paracellular channel, which allows asymmetric solute permeation. The ERK1/2 and JNK1/2 pathways may also be involved in the Zn 2+ -induced TJ opening process, while the activation of matrix metalloproteinase was not observed. Our results may suggest a potential role of zinc in regulation of BBB permeability associated with brain clearance of metabolites through the glymphatic system.

  18. TA-03-0035 Press Building – D&D

    Energy Technology Data Exchange (ETDEWEB)

    Hasenack, Marvin Leroy [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-11-02

    The Press Building was constructed in 1954 with 15,073 ft2 of floor space. It was built to house a 5000 ton double action Lake Erie hydraulic press and a uranium casting area. Missions included uranium activities associated with the Nuclear Weapons and Rover Rocket programs. At the end of the Rover program, the building continued to support various uranium materials science projects until the building was placed into a cold and dark status in 2013 and then was demolished in 2017. The building interior, the press, and associated systems were radiological contaminated and disposed of as low level waste. The demolition of this building opened up valuable real estate in the TA-3 area for the future construction of an ~11,000 Sq. Ft. Biosafety Level 2 laboratory and office building. This building will support the ongoing Bioscience Division mission at the laboratory.

  19. Natural Hazards and the press in the western Mediterranean region

    Directory of Open Access Journals (Sweden)

    M. Llasat-Botija

    2007-07-01

    Full Text Available This study analyses press articles published between 1982 and 2005 in an attempt to describe the social perception of natural hazards in Catalonia. The articles included in the database have been classified according to different types of risk. In addition, the study examines the evolution of each type of risk in the press coverage during the study period. Finally, the results have been compared to data provided by insurance companies with respect to compensations paid out for damages. Conclusions show that floods are the most important natural hazard in the region, but that the number of headlines for each event is greater in the case of snowfalls and forest fires. Factors such as the season of the year, the proximity of the affected region to the capital, the topical issues at the time, and the presence of other important news must be considered when the impact in the press is analysed.

  20. Asynchronous decision making in a memorized paddle pressing task.

    Science.gov (United States)

    Dankert, James R; Olson, Byron; Si, Jennie

    2008-12-01

    This paper presents a method for asynchronous decision making using recorded neural data in a binary decision task. This is a demonstration of a technique for developing motor cortical neural prosthetics that do not rely on external cued timing information. The system presented in this paper uses support vector machines and leaky integrate-and-fire elements to predict directional paddle presses. In addition to the traditional metrics of accuracy, asynchronous systems must also optimize the time needed to make a decision. The system presented is able to predict paddle presses with a median accuracy of 88% and all decisions are made before the time of the actual paddle press. An alternative bit rate measure of performance is defined to show that the system proposed here is able to perform the task with the same efficiency as the rats.

  1. The regulation of press freedoms (1863-1867

    Directory of Open Access Journals (Sweden)

    Laurence Coudart

    2015-10-01

    Full Text Available The main objective of this essay is to analyze the legislation affecting the press during the French Intervention and the Second Mexican Empire and establish their regulatory effects. These regulations are frequently ignored by the historiography. The article is limited to the origins, innovations, mechanisms and evolution of printing regulations during this period. As a whole, this allows the reader to observe the restrictive conception of press freedom held by the Mexican political class and their willingness, during the second half of the 19th Century, to turn to prohibitive, repressive, authoritarian and centralist legislation. The article also reveals the extent to which Imperial legislation and its logic of censorship were neither unprecedented nor sudden foreign impositions but instead the expressions of a long-lasting desire for government control over the press.

  2. Method for hot pressing irregularly shaped refractory articles

    Science.gov (United States)

    Steinkamp, William E.; Ballard, Ambrose H.

    1982-01-01

    The present invention is directed to a method for hot pressing irregularly haped refractory articles with these articles of varying thickness being provided with high uniform density and dimensional accuracy. Two partially pressed compacts of the refractory material are placed in a die cavity between displaceable die punches having compact-contacting surfaces of the desired article configuration. A floating, rotatable block is disposed between the compacts. The displacement of the die punches towards one another causes the block to rotate about an axis normal to the direction of movement of the die punches to uniformly distribute the pressure loading upon the compacts for maintaining substantially equal volume displacement of the powder material during the hot pressing operation.

  3. Advertising presence on the visual configuration of the digital press

    Directory of Open Access Journals (Sweden)

    Belinda de Frutos Torres

    2016-07-01

    Full Text Available Visual strength is responsible for one of the mayor changes undergone by the digital press with Internet explosion and the increase of the Informational and Communicational Technologies. The present study analyzes the structure the digital press has taken and the role of the digital advertisement in the composition of their textual and iconic elements. The paper quantifies the picture representations volume and compares their presence on the digital natives papers with those coming from the traditional paper support. The results reveal that there is a mayor contribution of adverts on the native on-line press compare to the on-line paper arriving from the traditional media decreasing the information volume. At the same time the visual volume is boosted on the former compare to the digital media with a paper support. Altogether it can be said that visual component prompted the digital papers first page, being this effect enhanced on the native digital papers.

  4. Film Advertising in the Albanian Press before World War II

    Directory of Open Access Journals (Sweden)

    Vjollca Hysi Panajoti

    2015-05-01

    Full Text Available This paper aims at studying the development of film advertising in the 1930’s Albanian press. Through advertising we struggle to read a piece of the Albanian monarchy’s history. Considering advertising as a historical source tends to reflect the economic, social and cultural life of the country. The study focused on the features, characteristics and uniqueness of advertising the films in relation to other ads present in print. Who were the people who created the ads, how does the Albanian press film advertising compare to advertising in the foreign press and what were the difficulties facing advertising at this time, are the other important issues addressed in this study. Over a century has passed since Harper's Weekly wrote that 'advertisements are a reflection of real life, a kind of fossil by which chroniclers can rewrite history in order to complete the graphic, even if all other historical evidence may have disappeared.

  5. Comparison of concentric and eccentric bench press repetitions to failure.

    Science.gov (United States)

    Kelly, Stephen B; Brown, Lee E; Hooker, Steven P; Swan, Pamela D; Buman, Matthew P; Alvar, Brent A; Black, Laurie E

    2015-04-01

    Eccentric muscle actions (ECC) are characterized by muscle lengthening, despite actin-myosin crossbridge formation. Muscles acting eccentrically are capable of producing higher levels of force compared with muscles acting concentrically. The purpose of this study was to determine whether ECC bench press yields greater strength than concentric (CON) as determined by 1 repetition maximum (1RM). Additionally, a comparison was made examining differences in the number of repetitions to failure at different relative intensities of 1RM. Thirty healthy men (age = 24.63 ± 5.6 years) were tested for 1RM in CON and ECC bench press and the number of repetitions completed at 60, 70, 80, and 90% 1RM. For CON repetitions, the weight was mechanically lowered to the chest, and the participant pressed it up until the elbows were fully extended. The ECC bench press consisted of lowering a barbell from a fully extended elbow position to the chest in a continuous controlled manner for 3 seconds as determined by electronic metronome. Paired t-tests showed that ECC 1RM (115.99 ± 31.08 kg) was significantly (p ≤ 0.05) greater than CON 1RM (93.56 ± 26.56 kg), and the number of repetitions completed at 90% 1RM was significantly (p ≤ 0.05) greater in ECC (7.67 ± 3.24) as compared with CON (4.57 ± 2.21). There were no significant differences in number of completed repetitions during CON and ECC bench press at 60, 70, and 80% 1RM. These data indicate that ECC actions yield increased force capabilities (∼120%) as compared with CON in the bench press and may be less prone to fatigue, especially at higher intensities. These differences suggest a need to develop unique strategies for training eccentrically.

  6. Process design of press hardening with gradient material property influence

    International Nuclear Information System (INIS)

    Neugebauer, R.; Schieck, F.; Rautenstrauch, A.

    2011-01-01

    Press hardening is currently used in the production of automotive structures that require very high strength and controlled deformation during crash tests. Press hardening can achieve significant reductions of sheet thickness at constant strength and is therefore a promising technology for the production of lightweight and energy-efficient automobiles. The manganese-boron steel 22MnB5 have been implemented in sheet press hardening owing to their excellent hot formability, high hardenability, and good temperability even at low cooling rates. However, press-hardened components have shown poor ductility and cracking at relatively small strains. A possible solution to this problem is a selective increase of steel sheet ductility by press hardening process design in areas where the component is required to deform plastically during crash tests. To this end, process designers require information about microstructure and mechanical properties as a function of the wide spectrum of cooling rates and sequences and austenitizing treatment conditions that can be encountered in production environments. In the present work, a Continuous Cooling Transformation (CCT) diagram with corresponding material properties of sheet steel 22MnB5 was determined for a wide spectrum of cooling rates. Heating and cooling programs were conducted in a quenching dilatometer. Motivated by the importance of residual elasticity in crash test performance, this property was measured using a micro-bending test and the results were integrated into the CCT diagrams to complement the hardness testing results. This information is essential for the process design of press hardening of sheet components with gradient material properties.

  7. Factors influencing the creep strength of hot pressed beryllium

    International Nuclear Information System (INIS)

    Webster, D.; Crooks, D.D.

    1975-01-01

    The parameters controlling the creep strength of hot pressed beryllium block have been determined. Creep strength was improved by a high initial dislocation density, a coarse grain size, and a low impurity content. The impurities most detrimental to creep strength were found to be aluminum, magnesium, and silicon. A uniform distribution of BeO was found to give creep strength which was inferior to a grain boundary distribution. The creep strength of very high purity, hot isostatically pressed beryllium was found to compare favorably with that of other more commonly used high temperature metals

  8. Vacuum hot pressing of titanium-alloy powders

    International Nuclear Information System (INIS)

    Malik, R.K.

    1975-01-01

    Full or nearly full dense products of wrought-metal properties have been obtained by vacuum hot pressing (VHP) of several prealloyed Ti--6Al--4V powders including hydride, hydride/dehydride, and rotating electrode process (REP) spherical powder. The properties of billets VHP from Ti--6Al--4V hydride powder and from hydride/dehydride powders have been shown to be equivalent. The REP spherical powder billets processed by VHP or by hot isostatic pressing (HIP) resulted in equivalent tensile properties. The potential of VHP for fabrication of near net aircraft parts such as complex fittings and engine disks offers considerable cost savings due to reduced material and machining requirements

  9. Ultrastructure, macromolecules, and evolution

    CERN Document Server

    Dillon, Lawrence S

    1981-01-01

    Thus far in the history of biology, two, and only two, fundamental principles have come to light that pervade and unify the entire science-the cell theory and the concept of evolution. While it is true that recently opened fields of inves­ tigation have given rise to several generalizations of wide impact, such as the universality of DNA and the energetic dynamics of ecology, closer inspection reveals them to be part and parcel of either of the first two mentioned. Because in the final analysis energy can act upon an organism solely at the cellular level, its effects may be perceived basically to represent one facet of cell me­ tabolism. Similarly, because the DNA theory centers upon the means by which cells build proteins and reproduce themselves, it too proves to be only one more, even though an exciting, aspect of the cell theory. In fact, if the matter is given closer scrutiny, evolution itself can be viewed as being a fundamental portion of the cell concept, for its effects arise only as a consequence ...

  10. Influence of the "Slingshot" bench press training aid on bench press kinematics and neuromuscular activity in competitive powerlifters.

    Science.gov (United States)

    Dugdale, James H; Hunter, Angus; Di Virgilio, Thomas; Macgregor, Lewis J; Hamilton, D Lee

    2017-02-13

    This study examined the acute effects of the 'Slingshot' on bench-press performance, prime-mover surface electromyographic (sEMG) amplitude, and barbell velocity during maximal and submaximal bench-pressing in competitive male powerlifters. Fifteen male powerlifters (mean ± SD age: 27.05 ± 5.94 years; mass: 94.15kg; 1RM bench-press: 139.7 ± 16.79kg) participated in the study. Bench-press strength, average barbell velocity, and sEMG amplitude of the prime mover muscles (triceps brachii, pectoralis major and anterior deltoid) were measured during two conditions; 'Raw' (without use of any assistance) and 'Slingshot' [using the 'Slingshot' to perform both the weight achieved during 'Raw' 1RM testing (Raw max/SS), and absolute 1RM using the 'Slingshot' (SS)]. The results showed that the 'Slingshot' significantly increased bench press 1RM performance by a mean ± SD of 20.67kg ± 3.4kg. Barbell velocity and stick point analysis indicate that this improvement is likely driven by an increase in peak and pre-stick barbell velocity as triceps RMS was lower throughout all rep max phases with the 'Slingshot'. The 'Slingshot' also caused reductions in RMS, specifically of the triceps at all rep ranges but barbell velocity was better maintained in the last reps of all sets. These data indicate that the 'Slingshot' specifically de-loaded the triceps muscle throughout all rep ranges and provide assistance to maintaining barbell velocity under fatigue during later repetitions of multiple-repetition sets. The 'Slingshot' training aid could therefore be used in de-load phases of bench press training or as an over-reaching and velocity training aid.

  11. Equal channel angular pressing of pure aluminium—an analysis

    Indian Academy of Sciences (India)

    Abstract. Equal channel angular pressing (ECAP) is a novel technique for producing ultra fine grain struc- tures in submicron level by introducing a large amount of shear strain into the materials without changing the billet shape or dimensions. This process is well suited for aluminium alloys and is capable of producing ultra.

  12. EMG analysis and modelling of flat bench press using artificial ...

    African Journals Online (AJOL)

    The objective of this study was to evaluate the contribution of particular muscle groups during the Flat Bench Press (FBP) with different external loads. Additionally, the authors attempted to determine whether regression models or Artificial Neural Networks (ANNs) can predict FBP results more precisely and whether they can ...

  13. Democratic Socialism: Toward a Fifth Theory of the Press.

    Science.gov (United States)

    Picard, Robert G.

    For more than 25 years, the "four theories" paradigm has been dominant in the study of the relationships among the press, society, and the state. Asserting that the major approaches to such study are the libertarian, social responsibility, authoritarian, and Soviet/communist theories, this paradigm fails to account for economic and…

  14. "...Establish the Student Press--And Stifle It!"

    Science.gov (United States)

    McCallie, Franklin

    1990-01-01

    Presents an acceptance speech by Franklin McCallie, principal of Kirkwood High School (Missouri), for the "Administrator of the Year" award presented by the Missouri Interscholastic Press Association and the Missouri Journalism Education Association in April 1989. Discusses journalism's role in achieving the school's chief goals: student growth,…

  15. Picture This: 4-H Press Corps Builds Life Skills

    Science.gov (United States)

    Clary, Christy D.

    2018-01-01

    A picture is worth a thousand words! Extension professionals are often looking for the picture that best captures an event and tells its story. Look beneath the surface, though, and a picture is worth much more. Developing a 4-H press corps results in a collection of useful photos but has the added benefit of providing 4-H members with an…

  16. Water holding capacity and enzymatic modification of pressed potato fibres

    NARCIS (Netherlands)

    Ramasamy, U.

    2014-01-01

    Cell wall polysaccharides (CWPs) contribute to the water holding capacity (WHC) of fibre rich feeds, such as pressed potato fibres (PPF). However, the role of CWPs on the WHC of PPF was unidentified so far.

    PPF was characterized to be abundant in arabinogalactan (AG) linked

  17. Quid pro quo: tobacco companies and the black press.

    Science.gov (United States)

    McCandless, Phyra M; Yerger, Valerie B; Malone, Ruth E

    2012-04-01

    We explored the relationship between tobacco companies and the Black press, which plays an important role in conveying information and opinions to Black communities. In this archival case study, we analyzed data from internal tobacco industry documents and archives of the National Newspaper Publishers Association (NNPA), the trade association of the Black press. In exchange for advertising dollars and other support, the tobacco industry expected and received support from Black newspapers for tobacco industry policy positions. Beginning in the 1990s, resistance from within the Black community and reduced advertising budgets created counterpressures. The tobacco industry, however, continued to sustain NNPA support. The quid pro quo between tobacco companies and the Black press violated journalistic standards and represented an unequal trade. Although numerous factors explain today's tobacco-related health disparities, the Black press's service to tobacco companies is problematic because of the trust that the community placed in such media. Understanding the relationship between the tobacco industry and the NNPA provides insight into strategies that the tobacco industry may use in other communities and countries.

  18. The nuclear issue in the cuban press. Challenges and realities

    International Nuclear Information System (INIS)

    Contreras Izquierdo, Marta; Rodriguez Guerra, Ingrids; Gonzalez Montoto, Iosbel; Fernandez Rondon, Manuel

    2005-01-01

    The work presents an analysis of the impact of nuclear issue on the Cuban press from 1990 to 2005 that was carried out by a group of communications specialists from nuclear area. An analysis of main challenges and actions of this group, aimed at informing the public the present situation of the Cuban nuclear programme and its perspectives, was also included

  19. Finishing procedures action on mechanical characteristics of pressed ceramics

    Directory of Open Access Journals (Sweden)

    Mohamed Abdel Moniem Ahmed

    2018-06-01

    Conclusions& significance: Grinding & finishing procedures of pressed ceramics showed significant effect Of drill speed and polishing technique over flexural strength, As Grinding with no finishing and polishing procedure showed lowest flexural Strength values followed by finishing and polishing procedure followed by finishing and polishing with polishing paste procedure.

  20. Process considerations for hot pressing ceramic nuclear waste forms

    International Nuclear Information System (INIS)

    Wilson, C.N.; Brite, D.W.

    1981-01-01

    Spray calcined simulated ceramic nuclear waste powders were hot pressed in graphite, nickel-lined graphite and ZrO 2 -lined Al 2 O 3 dies. Densification, initial off-gas, waste element retention and pellet-die interactions were evaluated. Indicated process considerations and limitations are discussed. 15 figures

  1. Press Ideology and Organizational Control in Hong Kong.

    Science.gov (United States)

    Chan, Joseph Man; Lee, Chin-Chuan

    1988-01-01

    Surveys the entire Chinese journalist population of Hong Kong to determine how news organizations in the highly politicized environment of Hong Kong exercise institutional control on recruitment and newswork. Finds that press ideology is a major determinant of its organizational control. (MS)

  2. Nanoindentation hardness of hot-pressed boron suboxide

    International Nuclear Information System (INIS)

    Machaka, Ronald; Derry, Trevor E.; Sigalas, Iakovos

    2011-01-01

    Highlights: → The load-displacement indentation response of hot-pressed B 6 O is measured and analysed. → The nanoindentation hardness of hot-pressed boron suboxide is reported. → An approach is developed to simulate multi-cycling loading load-displacement curves. → A comprehensive model inter-comparison study of the ISE in hot-pressed B 6 O is also presented. → The fractal dimension is a better measure of ISE than the Meyer's index. - Abstract: The existence of the indentation size effect implies the absence of a single hardness value for the material under investigation especially at low applied loads. In this paper we present an investigation of the indentation size dependence behaviour of nanoindentation hardness in boron suboxide ceramic compacts prepared by uniaxial hot-pressing. Berkovich nanohardness indentations were conducted and analyzed accordingly. In addition to the ordinary Oliver and Pharr method of nanoindentation data analysis, a quantitative approach for the loading curve analysis is proposed. Using the proposed approach, the description and characterization of the observed indentation size effect through the application of the Meyer's law, and the classical and the modified proportional specimen resistance models as well as the multi-fractal scaling law was conducted and is reported. The load-independent hardness values deduced from our quantitative approach are comparable to the results calculated with conventional methods, especially with the multi-fractal scaling law.

  3. Press travel to the Mochovce power plant in Slovakia

    International Nuclear Information System (INIS)

    1998-07-01

    This press dossier gives, first, a general presentation of the Mochovce power plant of the republic of Slovakia (history, technical characteristics, safety aspects, technical particularities of VVER 440/213 reactors (safety analysis, recent improvements), financing of the modernization project). Then, the activities of the Framatome group in central and eastern Europe are presented (partnerships, cooperation agreements and contracts). (J.S.)

  4. Constitutional Provisions on the Press: A World View.

    Science.gov (United States)

    Paraschos, Manny

    A study examined the legal treatment of the press in constitutions or other basic legal institutional documents from around the world. Sixty-three constitutions or basic documents from the Western World, the Communist Bloc, the Middle East, Africa, Southeast Asia, and Latin America were analyzed. Analysis revealed that most constitutions open with…

  5. A virtual model of the bench press exercise.

    Science.gov (United States)

    Rahmani, Abderrahmane; Rambaud, Olivier; Bourdin, Muriel; Mariot, Jean-Pierre

    2009-08-07

    The objective of this study was to design and validate a three degrees of freedom model in the sagittal plane for the bench press exercise. The mechanical model was based on rigid segments connected by revolute and prismatic pairs, which enabled a kinematic approach and global force estimation. The method requires only three simple measurements: (i) horizontal position of the hand (x(0)); (ii) vertical displacement of the barbell (Z) and (iii) elbow angle (theta). Eight adult male throwers performed maximal concentric bench press exercises against different masses. The kinematic results showed that the vertical displacement of each segment and the global centre of mass followed the vertical displacement of the lifted mass. Consequently, the vertical velocity and acceleration of the combined centre of mass and the lifted mass were identical. Finally, for each lifted mass, there were no practical differences between forces calculated from the bench press model and those simultaneously measured with a force platform. The error was lower than 2.5%. The validity of the mechanical method was also highlighted by a standard error of the estimate (SEE) ranging from 2.0 to 6.6N in absolute terms, a coefficient of variation (CV) or =0.99 for all the lifts (pbench press exercises in both field and laboratory conditions.

  6. The Surrender of Tobruk in 1942: Press reports and soldiers ...

    African Journals Online (AJOL)

    The British and South African papers began to demand answers from politicians and military leaders for this shocking and unexpected catastrophe. The press ... Keywords: Prisoners of war (POWs), World War II, Union Defence Force, Erwin Rommel, Auchinleck, Ritchie, HB Klopper, South Africa, Eighth Army, Gazala ...

  7. Toward a Normative Theory of Freedom of the Press.

    Science.gov (United States)

    Jensen, Dwight Wm.

    In considering the possibility of a normative theory of freedom of the press, this paper examines arguments about such freedom in the Third World and elsewhere. Some of the arguments discussed in the paper are derived from the theories of John Locke and Karl Marx; others are drawn from the concepts of divine rights, elitism, liberal democracy, and…

  8. Back-pressure Forging Using a Servo Press

    OpenAIRE

    河本, 基一郎; Kawamoto, Kiichiro

    2015-01-01

    博士論文要旨Abstract 以下に掲載:International Journal of Automation Technology 9(2) pp.184-192 2015. Fuji Technology Press Ltd. 共著者:Kiichiro Kawamoto, Takeshi Yoneyama, Masato Okada

  9. Nanoindentation hardness of hot-pressed boron suboxide

    Energy Technology Data Exchange (ETDEWEB)

    Machaka, Ronald, E-mail: Ronald.Machaka@wits.ac.za [DST/NRF Centre of Excellence in Strong Materials, University of the Witwatersrand, P. Bag 3, Wits, Johannesburg (South Africa); School of Chemical and Metallurgical Engineering, University of the Witwatersrand, P.O. Bag 3, Wits, Johannesburg 2050 (South Africa); Derry, Trevor E. [DST/NRF Centre of Excellence in Strong Materials, University of the Witwatersrand, P. Bag 3, Wits, Johannesburg (South Africa); School of Physics, University of the Witwatersrand, P.O. Bag 3, Wits, Johannesburg 2050 (South Africa); Sigalas, Iakovos [DST/NRF Centre of Excellence in Strong Materials, University of the Witwatersrand, P. Bag 3, Wits, Johannesburg (South Africa); School of Chemical and Metallurgical Engineering, University of the Witwatersrand, P.O. Bag 3, Wits, Johannesburg 2050 (South Africa)

    2011-07-15

    Highlights: {yields} The load-displacement indentation response of hot-pressed B{sub 6}O is measured and analysed. {yields} The nanoindentation hardness of hot-pressed boron suboxide is reported. {yields} An approach is developed to simulate multi-cycling loading load-displacement curves. {yields} A comprehensive model inter-comparison study of the ISE in hot-pressed B{sub 6}O is also presented. {yields} The fractal dimension is a better measure of ISE than the Meyer's index. - Abstract: The existence of the indentation size effect implies the absence of a single hardness value for the material under investigation especially at low applied loads. In this paper we present an investigation of the indentation size dependence behaviour of nanoindentation hardness in boron suboxide ceramic compacts prepared by uniaxial hot-pressing. Berkovich nanohardness indentations were conducted and analyzed accordingly. In addition to the ordinary Oliver and Pharr method of nanoindentation data analysis, a quantitative approach for the loading curve analysis is proposed. Using the proposed approach, the description and characterization of the observed indentation size effect through the application of the Meyer's law, and the classical and the modified proportional specimen resistance models as well as the multi-fractal scaling law was conducted and is reported. The load-independent hardness values deduced from our quantitative approach are comparable to the results calculated with conventional methods, especially with the multi-fractal scaling law.

  10. Press-fit bipolar radial head arthroplasty, midterm results

    NARCIS (Netherlands)

    Kodde, Izaäk F.; Heijink, Andras; Kaas, Laurens; Mulder, Paul G. H.; van Dijk, C. Niek; Eygendaal, Denise

    2016-01-01

    Theoretical advantages of bipolar compared with monopolar radial head arthroplasty include better accommodation of radiocapitellar malalignment, reduction of capitellar abrasion, and reduction of stress at the bone-implant interfaces. Our purpose was to report the midterm results of press-fit

  11. Book Review: Stars (Copyright 1985, Golden Press; New York)

    Science.gov (United States)

    Marigza, R. N., Jr.

    2009-06-01

    Stars is a part of the Golden Guides collection produced by Golden Press. It is a small 160 page paperback guide to the constellations, the sun, the moon, planets, and other celestial bodies. The book is convenient to carry along wherever you go, making it an easy to access reference material.

  12. Ethics and the Press: Readings in Mass Media Morality.

    Science.gov (United States)

    Merrill, John C., Ed.; Barney, Ralph D., Ed.

    This collection of 35 articles addresses the topic of the ethical considerations and implications involved in reporting the news. Included in this book are such articles as: "Ethics and Journalism" by John Merrill, "Quality in Mass Communications" by Wilbur Schramm, "The American Press: Some Truths About Truths" by…

  13. MICROSTRUCTURAL ANALYSIS OF HOT ISOSTATICALLY PRESSED AL-SIC

    NARCIS (Netherlands)

    Bronsveld, P.M.; Hosson, J.Th. De; Sargent, M.A.; Alsem, W.H.M.

    1991-01-01

    The difference between extruded and hot isostatically pressed (HIP) Al6061 both with a T6 final heat treatment and with a 30 wt.% SiC particulate reinforcement is one of densification. The higher density of the HIP material is not translated into a stronger material. The Mg2Si precipitation is

  14. FREEDOM OF SPEECH IN INDONESIAN PRESS: INTERNATIONAL HUMAN RIGHTS PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    Clara Staples

    2016-06-01

    Full Text Available This paper will firstly examine the international framework of human rights law and its guidelines for safeguarding the right to freedom of speech in the press. Secondly, it will describe the constitutional and other legal rights protecting freedom of speech in Indonesia and assess their compatibility with the right to freedom of speech under the international human rights law framework. Thirdly it will consider the impact of Indonesia’s constitutional law and criminal and civil law, including sedition and defamation laws, and finally media ownership, on the interpretation and scope of the right to freedom of speech in the press. Consideration of these laws will be integrated with a discussion of judicial processes. This discussion will be used to determine how and in what circumstances the constitutional right to freedom of speech in the press may be facilitated or enabled, or on the other hand, limited, overridden or curtailed in Indonesia. Conclusions will then be drawn regarding the strengths and weaknesses of Indonesian laws in safeguarding the right to freedom of speech in the press and the democratic implications from an international human rights perspective. This inquiry will be restricted to Indonesian laws in existence during the post-New Order period of 1998 to the present, and to the information and analysis provided by English-language sources.

  15. The Press of the Soviet Union: A Bibliography.

    Science.gov (United States)

    Bergethon, Bruce; And Others

    Compiled in response to the need for more information on the differences between the press systems of the United States and the Soviet Union, this bibliography contains 240 entries. Consisting of newspaper articles, journal articles, books, and pamphlets, the bibliography provides an overview of the different journalistic philosophies of the two…

  16. Introducing Collabra, OA Journal from University of California Press

    OpenAIRE

    Morgan, Daniel

    2015-01-01

    An introductory presentation of Collabra, the open access mega journal from University of California Press, highlighting its unique business model which shares and spreads revenue back to the research community. (Presented at the FORCE 2015 conference at the University of Oxford, January 13, 2015.)

  17. Student Press and Distribution Issues: Rights and Responsibilities.

    Science.gov (United States)

    Bartlett, Larry D.

    1984-01-01

    This review analyzes case law in the area of student press and distribution and offers some guidelines for developing and implementing school policy and rules. Litigation is reviewed in order to clarify students' rights, limitations on administrative authority in matters of censorship and prior restraint, and actions in connection with writing and…

  18. Performing “responsibility” and “conspiracy” through press ...

    African Journals Online (AJOL)

    In 2003, the Australian cricketer Shane Warne was suspected and convicted of doping. The purpose of this article was to understand how he tried to resolve the problem/dilemma of being suspected and convicted of doping through three press statements, which he delivered to the media during the 2003 Cricket World Cup ...

  19. Pleurotus pulmonarius cultivation on amended palm press fibre waste

    African Journals Online (AJOL)

    In the last few decades, rapid global demand for edible oils has resulted in a significant increase in the land area of oil crop cultivation. In the process of extraction of palm oil from oil palm fruit, biomass materials such as palm pressed fibre (PPF) are generated as waste products. This research was undertaken to evaluate ...

  20. The Press, the Government, and the Ethics Vacuum.

    Science.gov (United States)

    Merrill, John C.

    Immanuel Kant's idea of a will to do the right thing--to be ethical--is essentially a dead concept with both press and government. The reasons for this "ethics vacuum" are two-fold: the foundations of ethics in both circles are vague, confusing, and beset by relativism and pragmatism so that no system of ethics ever really coalesces; and neither…

  1. Finite element modelling and associated experimentations to optimize and predict the pressing cycle of a future AMBB manufacturing press

    International Nuclear Information System (INIS)

    Bayle, J.P.; Mezeix, P.; Tronche, E.; Delette, G.; Remy, E.; Picart, S.

    2014-01-01

    This study presents an approach based on the use of pellet forming numerical digital simulation which enables optimization of the die pressing cycle. Semi-empirical mechanical models were used in an FEM code, CAST3M. Specific powder characterizations were also performed to supply the mechanical parameters of compaction model. The methodology for the identification of five main coefficients (index flow, elastic and plastic parameters) was used with two different powders. The results show that the axial distribution of frictional forces may be changed during die pressing by a modification of the sequence of punch displacements. According to these results and the literature, the pressing cycle can be considered to have an influence on the shape of a sintered pellet through the axial distribution of green density. The process used for the identification of the Cam-Clay model coefficients seems to be in good agreement, even if the changes in certain parameters remain rather unclear and will require follow-up studies to confirm some of the results. The experimental device used produces good quality pellets, and the Radial Open Die Modulus remains the first choice for reduced pellet damage. Much work still remains to be done to fully define the identification process and create the most representative simulations possible before launching an industrial version of a nuclearized press, planned for the last quarter of year 2014. (authors)

  2. The Suburban Press; First Steps toward an Annotated Bibliography. Suburban Press Research Series No. 16 and 17.

    Science.gov (United States)

    Northern Illinois Univ., De Kalb. Suburban Press Research Center.

    This bibliography lists journal articles concerning various aspects of the suburban press. Annotated selections, arranged alphabetically according to journal title, are gathered from the following periodicals: "Advertising Age,""Business Week,""Columbia Journalism Review,""Editor and Publisher,""Grassroots Editor,""Journalism…

  3. Improving Dryer and Press Efficiencies Through Combustion of Hydrocarbon Emissions

    Energy Technology Data Exchange (ETDEWEB)

    Sujit Banerjee

    2005-10-31

    Emission control devices on dryers and presses have been legislated into the industry, and are now an integral part of the drying system. These devices consume large quantities of natural gas and electricity and down-sizing or eliminating them will provide major energy savings. The principal strategy taken here focuses on developing process changes that should minimize (and in some cases eliminate) the need for controls. A second approach is to develop lower-cost control options. It has been shown in laboratory and full-scale work that Hazardous Air Pollutants (HAPs) emerge mainly at the end of the press cycle for particleboard, and, by extension, to other prod-ucts. Hence, only the air associated with this point of the cycle need be captured and treated. A model for estimating terpene emissions in the various zones of veneer dryers has been developed. This should allow the emissions to be concentrated in some zones and minimized in others, so that some of the air could be directly released without controls. Low-cost catalysts have been developed for controlling HAPs from dryers and presses. Catalysts conventionally used for regenerative catalytic oxidizers can be used at much lower temperatures for treating press emissions. Fluidized wood ash is an especially inexpensive mate-rial for efficiently reducing formaldehyde in dryer emissions. A heat transfer model for estimating pinene emissions from hot-pressing strand for the manufacture of flakeboard has been constructed from first principles and validated. The model shows that most of the emissions originate from the 1-mm layer of wood adjoining the platen surface. Hence, a simple control option is to surface a softwood mat with a layer of hardwood prior to pressing. Fines release a disproportionate large quantity of HAPs, and it has been shown both theo-retically and in full-scale work that particles smaller than 400 µm are principally responsible. Georgia-Pacific is considering green

  4. An Update of Freedom of the Press and Information in Latin America and the Caribbean.

    Science.gov (United States)

    Garrison, Bruce; Munoz, Julio E.

    This paper is based on a review of the literature that included reports from the Inter-American Press Association's general assembly in Los Angeles in October 1984, the mid-year meeting of the Inter-American Press Association in Panama City in March 1985, and the 1983 world press freedom review of the International Press Institute. Other material…

  5. Effects of wet-pressing-induced fiber hornification on enzymatic saccharification of lignocelluloses

    Science.gov (United States)

    X.L. Luo; Junyong Zhu; Roland Gleisner; H.Y. Zhan

    2011-01-01

    This article reports the effect of wet-pressing-induced fiber hornification on enzymatic saccharification of lignocelluloses. A wet cellulosic substrate of bleached kraft eucalyptus pulp and two wet sulfite-pretreated lignocellulosic substrates of aspen and lodgepole pine were pressed to various moisture (solids) contents by variation of pressing pressure and pressing...

  6. Hot pressing, strength, and fracture of calcium hexaboride

    International Nuclear Information System (INIS)

    Dutta, S.K.

    1975-01-01

    Fracture behavior and strength of hot-pressed CaB 6 were studied. The modulus of elasticity determined by attaching strain gages to the tensile surface of the bend bars to measure strain, was 55 +- 3 x 10 6 psi. The results are compared with values for other low density ceramic materials (B 4 C, SiB 6 , Be 4 B, AlB 12 ) in a table. The fracture mode was observed for both modulus of rupture and impact test specimens. Predominantly transgranular fracture, associated with distinct step cleavages is evident. Fracture origins were examined in an effort to understand the strength limiting features in hot-pressed CaB 6 specimens. Surface defects, large grain agglomerations, and isolated pore pockets were observed and varied from bar to bar; these were similar to those found in B 4 C. (U.S.)

  7. Pressing Speed, Specific Pressure and Mechanical Properties of Aluminium Cast

    Directory of Open Access Journals (Sweden)

    Gaspar S.

    2016-06-01

    Full Text Available Recent research in the process of aluminum alloy die castings production, which is nowadays deeply implemented into the rapidly growing automobile, shipping and aircraft industries, is aimed at increasing the useful qualitative properties of the die casting in order to obtain its high mechanical properties at acceptable economic cost. Problem of technological factors of high pressure die casting has been a subject of worldwide research (EU, US, Japan, etc.. The final performance properties of die castings are subjected to a large number of technological factors. The main technological factors of high pressure die casting are as follows: plunger pressing speed, specific (increase pressure, mold temperature as well as alloy temperature. The contribution discusses the impact of the plunger pressing speed and specific (increase pressure on the mechanical properties of the casting aluminum alloy.

  8. Research on the Visual Processing System of the Punch Press

    Directory of Open Access Journals (Sweden)

    Sun Xuan

    2016-01-01

    Full Text Available Most of raw materials of small hardware processing for plate scraps, and it’s realized through the manual operation of ordinary punch, which way has the low production efficiency and the high labor intensity. In order to improve the automation level of production, developing and designing of a visual processing system for punch press manipulator which based on the MFC tools of Visual Studio software platform. Through the image acquisition and image processing, get the information about the board to be processed, such as shape, length, the center of gravity position and pose, and providing relevant parameters for positioning gripping and placing into the punch table positioning of the feeding manipulator and automatic programming of punching machine, so as to realize the automatic operation about press feeding and processing.

  9. Social Representations of the Environment in Press Media

    Directory of Open Access Journals (Sweden)

    Gislei Mocelin Polli

    2015-08-01

    Full Text Available Environmental issues are given prominence in the media and scientific circles. From the 60’s until early 2010 there were changes in the way people related to the environment, with a paradigm shift occurring regarding the environment. This study sought to identify the representational content disseminated by the press media on the environment in different periods. A qualitative survey was therefore conducted of documents, and data were obtained through texts published in a magazine with national circulation. The data were analyzed using the ALCESTE program with a Lexicographic Analysis. It was identified that the press media reflects the paradigm shifts, and publications dating from the late 60’s are compatible with the old paradigm, evolving over time, and are now compatible with the new environmental paradigm. The results indicate that currently the environment needs care in all its aspects and lack of care creates global impacts.

  10. News from the Library: newspapers anyone? Try PressDisplay!

    CERN Multimedia

    CERN Library

    2011-01-01

    PressDisplay is an online portal where you can browse and read online articles from more than 1,900 newspapers from 95 countries, as soon as they are published. With Pressdisplay, the time when newspapers were nicely displayed on wooden rods in libraries has passed...   Le Monde, International Herald Tribune and many more titles are displayed in their original layout including text and images, and you can print and e-mail the articles you are interested in. You even have the possibility to create rss feeds, so that the news reaches you directly.   The CERN Library has now activated a trial version of PressDisplay valid till 31 December; it is open to everyone at CERN. This trial doesn't offer the possibility to create personalised alerts based on specific search criteria. In case you need such features - or if you have any comments or questions - please contact us.

  11. Reducing VOC Press Emission from OSB Manufacturing; FINAL

    International Nuclear Information System (INIS)

    Gary D, McGinnis; Laura S, WIlliams; Amy E, Monte; Jagdish Rughani; Brett A, Niemi; Thomas M, Flicker

    2001-01-01

    Current regulations require industry to meet air emission standards with regard to particulates, volatile organic compounds (VOCs), hazardous air pollutants (HAPs) and other gases. One of many industries that will be affected by the new regulations is the wood composites industry. This industry generates VOCs, HAPs, and particulates mainly during the drying and pressing of wood. Current air treatment technologies for the industry are expensive to install and operate. As regulations become more stringent, treatment technologies will need to become more efficient and cost effective. The overall objective of this study is to evaluate the use of process conditions and chemical additives to reduce VOC/HAPs in air emitted from presses and dryers during the production of oriented strand board

  12. Indonesian journalistic competitions: tribute or threat for press practice

    Science.gov (United States)

    Dewi, P. A. R.; Aji, G. G.; Sukardani, P. S.

    2018-01-01

    This research aims to Investigate journalists’ understanding toward glittering generalities practice - positive and good coverage of the caused by the Journalistic contests, the prices are attracting them, Reviews their motives to Participate, and their beliefs about ethics al thing. It is also retrieve how the chief editor, as a decision maker in the mass media taking his responsibility on the glittering news. This research uses a case study method by conducting indepth interviews on journalists, editors, and professional the alliance to collect the data and analyse it based on critical paradigm. The results show that journalist believe that competition is good, and there is no violation as long as the stick to the press code of conduct, but for chief editors and professional alliance, they begin to aware the damage of the contest. The findings of this work will be valuable to develop critical thinking of press workers and promote awareness to the society to control the media practice.

  13. A new cleaner process to prepare pressing-powder

    Directory of Open Access Journals (Sweden)

    Shu, Z.

    2011-10-01

    Full Text Available An alternative cleaner process of pressing-powder preparation, based on filter-pressing and a novel granulation method, is presented to substitute the existing spray-drying process. In the new process, about two-thirds of wet-milled slurry is filterpressed, dried and milled into dry fine powder. The other one-third of the slurry and the as-obtained dry fine powder are spray-mixed in a tower, where the slurry droplets adsorb the dry powder to form granules which are then rolled and dried into a useable pressing-powder for tile pressing. The key stages, filter-pressing and granulation (consisting of spray-mixing and rolling treatment, are specially studied. The pressing-powder properties and pressing/firing behavior, and, energy/water consumption and pollution emission data are presented, and a comparison between the new process and the existing spray-drying process is made. This new process has been found to be feasible and provides a pressing-powder with suitable properties, together with lower energy/water consumption and pollution emission (particulate matter and CO2.

    En ese trabajo se presenta un proceso alternativo y más ecológico para la preparación de polvo de prensas por molienda vía húmeda de las materias primas. En este proceso la eliminación del agua de la suspensión obtenida en la etapa de molienda, en vez de realizarse por secado por atomización, se lleva a cabo en dos etapas, en una primera etapa dos tercios de esta suspensión se filtro-prensan, posteriormente se secan y molturan hasta obtener un polvo seco micronizado. Este material seco se introduce por la parte superior de una torre granuladora, en la que se pulveriza el tercio de la suspensión restante por la parte inferior, de forma que las gotas adsorben sobre su superficie las partículas secas formando gránulos, que posteriormente se compactan por rodamiento (“rolling”, y finalmente se secan hasta la humedad requerida para el prensado. En

  14. Different Visions of Framing Violence in International Press News

    DEFF Research Database (Denmark)

    Ramirez, Jacobo

    in Mexico and to explore entrepreneurs’ reaction to the covered news. We also analyze journalists’ treatment of this news (Semetko & Valkendurg, 2000) and differences among newspapers from the U.S., Mexico and the European Union (EU). A sample of 200 news histories was constructed by integrating...... international and Mexican newspapers from 2006 to 2012. Our results showed that overall, U.S. and EU newspapers present more news related to violence towards entrepreneurs than Mexican outlets, which more often adopt the avoid strategy (Oliver, 1991). The conflict frame was more widely used in EU newspapers...... than in U.S. and Mexican newspapers, and the economic frame was more present in the U.S. and Mexican press than in the EU press. The morality frame was used more frequently by Mexican journalists than U.S. and European journalists. The results made it possible to observe the effects of framing...

  15. Visual impact in the digital press: a Spanish empirical research

    Directory of Open Access Journals (Sweden)

    Joan Francesc Fondevila Gascón

    2010-12-01

    Full Text Available Visual resource (photography and video inclusion in digital journalism is obtaining importance in the multimedia area. The principal resources of digital press are multimedia, hypertext and interactivity. Multimedia is in an initial process of evolution. The objective of this research is to observe empirically the use of visual resources by the digital pure player press. These media try to take advantage of the new multimedia possibilities in the development and presentation of the contents. We have analyzed empirically video and photography inclusion in the multimedia framework (text, photography, video, audio, infograph and animation programs in four digital newspapers (Libertad Digital and El Plural, in Spanish, and Vilaweb.cat and e-Noticies, in Catalan analyzed according to journalistic genres.

  16. Convicted Murderers and the Victorian Press: Condemnation vs. Sympathy

    Directory of Open Access Journals (Sweden)

    Martin J. Wiener

    2007-11-01

    Full Text Available Almost half of those receiving the death sentence in late-Victorian and Edwardian England were reprieved. The process of deciding which murderers were to hang and which were to be spared became an increasingly public one, thanks to the growing intervention of the press. This intervention grew alongside the accelerated expansion in the numbers and circulations of newspapers in the second half of the nineteenth century. As the press became a larger part of national life, its more „popular‟ and its more local segments carved out for themselves a new and ever more prominent role as major participants in public discourse over „justice‟ vs. „mercy‟ for condemned murderers. This involvement is a facet of Victorian and Edwardian newspapers that has previously been overlooked.

  17. Hot Isostatic Press (HIP) vitrification of radwaste concretes

    International Nuclear Information System (INIS)

    Siemer, D.D.; Scheetz, B.; Gougar, M.L.D.

    1995-01-01

    Properly formulated and properly ''canned'' radwaste concretes can be readily hot-isostatically-pressed (HIPed) into materials that exhibit performance equivalent to typical radwaste-type glasses. The HIPing conditions (temperature/pressure) required to turn a concrete waste form into a ''vitrified'' waste form are quite mild and therefore consistent with both safety and high productivity. This paper describes the process and its products with reference to its potential application to Idaho Chemical Processing Plant (ICPP) reprocessing wastes

  18. Mediated Nationalism: Press Freedom, Mass Media, and Nationalism

    Science.gov (United States)

    2017-12-01

    spread propaganda resulted in a positive response by listeners who were predisposed to anti-Semitism and a negative response by those whose prior...2016/jun/11/ david-cameron-brexit-eu-referendum- listen -jeremy-corbyn. 5 Nations with a censored press would likely have denied the expression of...nationalism. Those “who can understand them, or can acquire such comprehension is included in a moral and economic community.”45 He states that “what is

  19. Biological effects of the ionizing radiation. Press breakfast

    International Nuclear Information System (INIS)

    Flury-Herard, A.; Boiteux, S.; Dutrillaux, B.; Toledano, M.

    2000-06-01

    This document brings together the subjects discussed during the Press breakfast of 29 june 2000 on the biological effects of the ionizing radiations, with scientists of the CEA and the CNRS. It presents the research programs and provides inquiries on the NDA operating to introduce the NDA damages by ionizing radiations, the possible repairs and the repair efficiency facing the carcinogenesis. Those researches allow the scientists to define laws on radiation protection. (A.L.B.)

  20. FREEDOM OF SPEECH IN INDONESIAN PRESS: INTERNATIONAL HUMAN RIGHTS PERSPECTIVE

    OpenAIRE

    Clara Staples

    2016-01-01

    This paper will firstly examine the International framework of human rights law and its guidelines for safeguarding the right to freedom of speech in the press. Secondly, it will describe the constitutional and other legal rights protecting freedom of speech in Indonesia and assess their compatibility with the right to freedom of speech under the International human rights law framework. Thirdly it will consider the impact of Indonesia's constitutional law and criminal and civil law, includin...

  1. Mechanical and thermophysical properties of hot-pressed SYNROC B

    International Nuclear Information System (INIS)

    Hoenig, C.L.; Newkirk, H.W.; Otto, R.A.; Brady, R.L.; Brown, A.E.; Ulrich, A.R.; Lum, R.C.

    1981-01-01

    The optimal SYNROC compositons for use with commercial waste are reviewed. Large amounts of powder (about 2.5 kg) were prepared by convention al ceramic operations to test the SYNROC concept on a processing scale. Samples, 15.2 cm in diameter, were hot pressed in graphite, and representative samples were cut for microstructural evaluations. Measured mechanical and thermophysical properties did not vary significantly as a function of sample location and were typical of titanate ceramic materials

  2. Film Advertising in the Albanian Press before World War II

    OpenAIRE

    Vjollca Hysi Panajoti; Mirdaim Axhami; Loreta Zela Axhami

    2015-01-01

    This paper aims at studying the development of film advertising in the 1930’s Albanian press. Through advertising we struggle to read a piece of the Albanian monarchy’s history. Considering advertising as a historical source tends to reflect the economic, social and cultural life of the country. The study focused on the features, characteristics and uniqueness of advertising the films in relation to other ads present in print. Who were the people who created the ads, how does the ...

  3. The Social Theories of the press: journalism and society

    Directory of Open Access Journals (Sweden)

    Beatriz Marocco

    2005-06-01

    Full Text Available For a short period of time, between the end of the 19th century and the middle of the 20th, newspapers and journalists were under the spotlight as never before. However, the comprehensive reviews of the theories of the press do not acknowledge the thought of this period and its development into “the social theories of the press” (H. Hardt, 1979. This article is positioned in this gap of press studies, and it uses as a starting point the foucaultian description of the diff erent thresholds that establish the levels of discourse elaboration (Foucault, 1995. It aims at exploring the theoretical production that approximates German and American scholars such as Albert Schäffle (1831-1903; Karl Knies (1821-1898; Karl Bücher (1847-1930; Ferdinand Tönnies (1835-1936; Albion Small (1854-1926; Edward Ross (1856-1951; Max Weber (1864-1920; Robert Park (1864-1944 and Walter Lippmann (1889-1974, rescuing this production from the pre-history of the press to materialize evidence that this production coincides, in its external origin, with the modern newspaper practices, although there seemed to be no dependence between them at the time.

  4. The Social Theories of the press: journalism and society

    Directory of Open Access Journals (Sweden)

    Beatriz Marocco

    2011-02-01

    Full Text Available For a short period of time, between the end of the 19th century and the middle of the 20th, newspapers and journalists were under the spotlight as never before. However, the comprehensive reviews of the theories of the press do not acknowledge the thought of this period and its development into “the social theories of the press” (H. Hardt, 1979. This article is positioned in this gap of press studies, and it uses as a starting point the foucaultian description of the diff erent thresholds that establish the levels of discourse elaboration (Foucault, 1995. It aims at exploring the theoretical production that approximates German and American scholars such as Albert Schäffle (1831-1903; Karl Knies (1821-1898; Karl Bücher (1847-1930; Ferdinand Tönnies (1835-1936; Albion Small (1854-1926; Edward Ross (1856-1951; Max Weber (1864-1920; Robert Park (1864-1944 and Walter Lippmann (1889-1974, rescuing this production from the pre-history of the press to materialize evidence that this production coincides, in its external origin, with the modern newspaper practices, although there seemed to be no dependence between them at the time.

  5. Graphite and boron carbide composites made by hot-pressing

    International Nuclear Information System (INIS)

    Miyazaki, K.; Hagio, T.; Kobayashi, K.

    1981-01-01

    Composites consisting of graphite and boron carbide were made by hot-pressing mixed powders of coke carbon and boron carbide. The change of relative density, mechanical strength and electrical resistivity of the composites and the X-ray parameters of coke carbon were investigated with increase of boron carbide content and hot-pressing temperature. From these experiments, it was found that boron carbide powder has a remarkable effect on sintering and graphitization of coke carbon powder above the hot-pressing temperature of 2000 0 C. At 2200 0 C, electrical resistivity of the composite and d(002) spacing of coke carbon once showed minimum values at about 5 to 10 wt% boron carbide and then increased. The strength of the composite increased with increase of boron carbide content. It was considered that some boron from boron carbide began to diffuse substitutionally into the graphite structure above 2000 0 C and densification and graphitization were promoted with the diffusion of boron. Improvements could be made to the mechanical strength, density, oxidation resistance and manufacturing methods by comparing with the properties and processes of conventional graphites. (author)

  6. Production of press moulds by plasma spray forming process

    International Nuclear Information System (INIS)

    Borisov, Y.; Myakota, I.; Polyakov, S.

    2001-01-01

    Plasma spray forming process for production of press moulds which are used for manufacture of articles from plastics was developed. The press moulds were produced by plasma spraying of Cu-Al-Fe-alloy powder on surface of a master model. The master models were made from non-metallic materials with heat resistance below 70 C (wood, gypsum etc). Double cooling system which provides for a control of surface model temperature and quenching conditions of sprayed material was designed. It made possible on the one hand to support model surface temperature below 70 C and on the other hand to provide for temperature conditions of martensite transformation in Cu-Al-system with a fixation of metastable ductile α + β 1 -phase. This allowed to decrease residual stresses in sprayed layer (up to 0,5-2,5 MPa), to increase microhardness of the coating material (up to 1200-1800 MPa) and its ductility (σ B = 70-105 MPa, δ = 6-12 %). This plasma spray forming process makes possible to spray thick layers (5-20 mm and more) without their cracking and deformation. The process is used for a production of press moulds which are applied in shoes industry, for fabrication of toys, souvenirs etc. (author)

  7. Research Facility for Mechanical Press Closed Gap Adjuster

    Directory of Open Access Journals (Sweden)

    A. A. Ancifirov

    2016-01-01

    Full Text Available The article describes an example of the research facility for closed gap adjustment mechanism based on the KD2128 closed-die forging press. Its rated force with a servo drive used is 630kN. The servo drive consists of a motor with nominal power of 1.57kW and a frequency converter with power of 7.5kW, which has functions of the programmable logic controller.The article notes that such a facility is expedient and useful for practical classes on forging-andstamping machines at the BMSTU Department of «Technology processing by pressure» to demonstrate the capabilities of existing technological facility, learn a design of forging-andstamping machine units, solve the problems of automatic control, monitoring, and diagnostics in blank manufacturing.The article presents a detailed facility diagram of the closed gap adjustment mechanism and its photograph, describes the mechanism and its basic parameters, gives characteristics of the synchronous motor to drive the mechanism, reviews practical works, which the research facility may provide.Based on the four experiments the article estimates an efficiency of the research facilityuse under consideration, especially when modeling a servo motor shaft under the maximum load. The relevant diagrams confirm experimental results, namely: control current, angle of motor shaft and its speed versus time. Thus, upon the diagram analysis it can be noted that the research facility design allows providing kinematics and dynamics of the press closed gap adjuster.This article describes how to determine the closed gap adjusting accuracy of the press. Eight experiments have been conducted to evaluate a working out control signal to the linear movement of the press punch when using the research facility. It is noted that the linear positioning accuracy of the press punch reaches the hundredth parts of a millimeter of the adjustment value that is sufficient to achieve the required precision when performing operations such as

  8. The antimatter. Press breakfast 23 may 2000; L'antimatiere. Petit dejeuner de presse 23 mai 2000

    Energy Technology Data Exchange (ETDEWEB)

    Spiro, M; Dejardin, M; Debu, P; Aleksan, R [CEA/Saclay, Dept. d' Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l' Instrumentation Associee (DAPNIA), 91 - Gif-sur-Yvette (France)

    2000-05-01

    This document brings together the subjects discussed during the Press breakfast of 23 may 2000 on the antimatter, with scientists of the CEA and the CNRS. It presents the research programs and the experiments on the antimatter and the symmetry violation: the CP LEAR and the NA48 experiments at CERN, the BaBar detector at SLAC, the fundamental research at the CEA and the impacts on the energy policy. It provides also links for more detailed inquiries. (A.L.B.)

  9. Biological effects of the ionizing radiation. Press breakfast; Effets biologiques des rayonnements ionisants. Petit dejeuner de presse

    Energy Technology Data Exchange (ETDEWEB)

    Flury-Herard, A [CEA, Direction des Sciences du Vivant, DSV, 75 - Paris (France); Boiteux, S; Dutrillaux, B [CEA/Fontenay-aux-Roses, Direction des Sciences du Vivant, DSV, 92 (France); Toledano, M [CEA Saclay, Direction des Sciences du Vivant, DSV, 91 - Gif-sur-Yvette (France)

    2000-06-01

    This document brings together the subjects discussed during the Press breakfast of 29 june 2000 on the biological effects of the ionizing radiations, with scientists of the CEA and the CNRS. It presents the research programs and provides inquiries on the NDA operating to introduce the NDA damages by ionizing radiations, the possible repairs and the repair efficiency facing the carcinogenesis. Those researches allow the scientists to define laws on radiation protection. (A.L.B.)

  10. Effect of α-tocopherol, butylated-hydroxytoluene and hydroxy-anisole on the activation and binding of aflatoxin B1 to macromolecules

    International Nuclear Information System (INIS)

    Ch'ih, J.J.; Biedrzycka, D.; Devlin, T.M.

    1987-01-01

    The anti-oxidants, α-tocopherol(TPA), butylated-hydroxy-toluene(BHT) and hydroxyanisole(BHA) inhibit the carcinogenic and toxic effects of a variety of chemical compounds, their effect on aflatoxin B 1 (AFB 1 ) activation and binding was examined utilizing rat liver microsomes and cells. With a NADPH generating system, oxygen, microsomes, [ 3 H]-AFB 1 , 2.2 pmoles/h/mg protein was activated and bound to macromolecules. In hepatocytes, 3.4 and 1.4 pmoles of AFB 1 per 10 6 cells were taken up and bound to macromolecules, whereas the nucleic acid fraction contained 0.19 pmoles of bound AFB 1 . Moderate decreases of AFB 1 activation and binding were observed when TPA was present in both cell-free and hepatocytes systems. Only in hepatocytes, BHT inhibited the AFB 1 uptake and binding to nucleic acids. BHA, however, inhibited microsomal activation of AFB 1 by 73%; maximum inhibition was reached at 1 mM. AFB 1 uptake, and binding to nucleic acids were inhibited by 65% and 79% by BHA. GSH-transferase activity of cells treated with these agents was not altered. The effect of BHA at various concentrations on AFB activation was compared with cytochrome P-450 inhibitors; the ED 50 of SKF 525A, BHA and metyrapone was 9 uM, 80 uM and 380 uM respectively. The data suggest that TPA, BHA and BHT exert their effect by different mechanisms

  11. Surface engineering of nanoparticles with macromolecules for epoxy curing: Development of super-reactive nitrogen-rich nanosilica through surface chemistry manipulation

    Science.gov (United States)

    Jouyandeh, Maryam; Jazani, Omid Moini; Navarchian, Amir H.; Shabanian, Meisam; Vahabi, Henri; Saeb, Mohammad Reza

    2018-07-01

    Curing behavior of epoxy-based nanocomposites depends on dispersion state of nanofillers and their physical and chemical interactions with the curing moieties. In this work, a systematic approach was introduced for chemical functionalization of nanoparticles with macromolecules in order to enrich crosslinking potential of epoxy/amine systems, particularly at late stages of cure where the curing is diffusion-controlled. Super-reactive hyperbranched polyethylenimine (PEI)-attached nanosilica was materialized in this work to facilitate epoxy-amine curing. Starting from coupling [3-(2,3-epoxypropoxy) propyl] trimethoxysilane (EPPTMS) with hyperbranched PEI, a super-reactive macromolecule was obtained and subsequently grafted onto the nanosilica surface. Eventually, a thermally-stable highly-curable nanocomposite was attained by replacement of amine and imine groups of the PEI with imide and amide groups through the reaction with pyromellitic acid dianhydride. Fourier-transform infrared spectrophotometry, X-ray diffractometry, X-ray photoelectron spectroscopy and transmission electron microscopy approved successful grafting of polymer chains onto the nanosilica surface. Thermogravimetric analyses approved a relatively high grafting ratio of ca. 21%. Curing potential of the developed super-reactive nanoparticle was uncovered through nonisothermal differential scanning calorimetry signifying an enthalpy rise of ca. 120 J/g by addition of 2 wt.% to epoxy at 5 °C/min heating rate. Even at low concentration of 0.5 wt.%, the glass transition temperature of epoxy increased from 128 to 156 °C, demonstrating prolonged crosslinking.

  12. A polymeric micelle magnetic resonance imaging (MRI) contrast agent reveals blood-brain barrier (BBB) permeability for macromolecules in cerebral ischemia-reperfusion injury.

    Science.gov (United States)

    Shiraishi, Kouichi; Wang, Zuojun; Kokuryo, Daisuke; Aoki, Ichio; Yokoyama, Masayuki

    2017-05-10

    Blood-brain barrier (BBB) opening is a key phenomenon for understanding ischemia-reperfusion injuries that are directly linked to hemorrhagic transformation. The recombinant human tissue-type plasminogen activator (rtPA) increases the risk of symptomatic intracranial hemorrhages. Recent imaging technologies have advanced our understanding of pathological BBB disorders; however, an ongoing challenge in the pre-"rtPA treatment" stage is the task of developing a rigorous method for hemorrhage-risk assessments. Therefore, we examined a novel method for assessment of rtPA-extravasation through a hyper-permeable BBB. To examine the image diagnosis of rtPA-extravasation for a rat transient occlusion-reperfusion model, in this study we used a polymeric micelle MRI contrast-agent (Gd-micelles). Specifically, we used two MRI contrast agents at 1h after reperfusion. Gd-micelles provided very clear contrast images in 15.5±10.3% of the ischemic hemisphere at 30min after i.v. injection, whereas a classic gadolinium chelate MRI contrast agent provided no satisfactorily clear images. The obtained images indicate both the hyper-permeable BBB area for macromolecules and the distribution area of macromolecules in the ischemic hemisphere. Owing to their large molecular weight, Gd-micelles remained in the ischemic hemisphere through the hyper-permeable BBB. Our results indicate the feasibility of a novel clinical diagnosis for evaluating rtPA-related hemorrhage risks. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Molar mass, radius of gyration and second virial coefficient from new static light scattering equations for dilute solutions: application to 21 (macro)molecules.

    Science.gov (United States)

    Illien, Bertrand; Ying, Ruifeng

    2009-05-11

    New static light scattering (SLS) equations for dilute binary solutions are derived. Contrarily to the usual SLS equations [Carr-Zimm (CZ)], the new equations have no need for the experimental absolute Rayleigh ratio of a reference liquid and solely rely on the ratio of scattered intensities of solutions and solvent. The new equations, which are based on polarizability equations, take into account the usual refractive index increment partial differential n/partial differential rho(2) complemented by the solvent specific polarizability and a term proportional to the slope of the solution density rho versus the solute mass concentration rho(2) (density increment). Then all the equations are applied to 21 (macro)molecules with a wide range of molar mass (0.2equations clearly achieve a better agreement with supplier M values. For macromolecules (M>500 kg mol(-1)), for which the scattered intensity is no longer independent of the scattering angle, the new equations give the same value of the radius of gyration as the CZ equation and consistent values of the second virial coefficient.

  14. The anchorless adhesin Eap (extracellular adherence protein) from Staphylococcus aureus selectively recognizes extracellular matrix aggregates but binds promiscuously to monomeric matrix macromolecules.

    Science.gov (United States)

    Hansen, Uwe; Hussain, Muzaffar; Villone, Daniela; Herrmann, Mathias; Robenek, Horst; Peters, Georg; Sinha, Bhanu; Bruckner, Peter

    2006-05-01

    Besides a number of cell wall-anchored adhesins, the majority of Staphylococcus aureus strains produce anchorless, cell wall-associated proteins, such as Eap (extracellular adherence protein). Eap contains four to six tandem repeat (EAP)-domains. Eap mediates diverse biological functions, including adherence and immunomodulation, thus contributing to S. aureus pathogenesis. Eap binding to host macromolecules is unusually promiscuous and includes matrix or matricellular proteins as well as plasma proteins. The structural basis of this promiscuity is poorly understood. Here, we show that in spite of the preferential location of the binding epitopes within triple helical regions in some collagens there is a striking specificity of Eap binding to different collagen types. Collagen I, but not collagen II, is a binding substrate in monomolecular form. However, collagen I is virtually unrecognized by Eap when incorporated into banded fibrils. By contrast, microfibrils containing collagen VI as well as basement membrane-associated networks containing collagen IV, or aggregates containing fibronectin bound Eap as effectively as the monomeric proteins. Therefore, Eap-binding to extracellular matrix ligands is promiscuous at the molecular level but not indiscriminate with respect to supramolecular structures containing the same macromolecules. In addition, Eap bound to banded fibrils after their partial disintegration by matrix-degrading proteinases, including matrix metalloproteinase 1. Therefore, adherence to matrix suprastructures by S. aureus can be supported by inflammatory reactions.

  15. Results and problems in the development of machines employed in pressing technology

    Energy Technology Data Exchange (ETDEWEB)

    Dietrich, P; Hinne, H; Linke, L; Nerger, R

    1980-08-01

    Features specifications and technical improvements of nine GDR made briquetting presses from the Zemag Zeitz company. Briquetting presses have been produced by the company for more than 100 years, the present capacity of the machines ranges from 5.1 t/h to 20.4 t/h of nominal briquet production. Development trends are directed toward larger presses. The prototype PSA 400, based on the design of the four channel press PSA 300, will be tested in industrial operation during 1980/81. Various technical details on the general briquetting press design are enumerated, including experiences gained with steam or electric power operated presses, regulation of the pressing speed with a patented switch gear system, maintenance of crank gear bearings, greasing of steam driven presses, investigation of crack damages to the machine block, further measures for reducing wear of the pressing channel and mechanized welding methods for the channel overhaul. (In German)

  16. Clarification of Orange Press Liquors by PVDF Hollow Fiber Membranes

    Directory of Open Access Journals (Sweden)

    Silvia Simone

    2016-01-01

    Full Text Available Press liquors are typical by-products of the citrus juice processing characterized by a high content of organic compounds and associated problems of environmental impact, which imply high treatment costs. However, these wastes contain a great number of health promoting substances, including fibers, carotenoids and phenolic compounds (mainly flavonoids, whose recovery against waste-destruction technologies is very attractive for new business opportunities. In this work, the clarification of orange press liquor by using microfiltration (MF membranes is studied as a preliminary step to obtain a permeate stream enriched in antioxidant compounds which can be further processed to produce extracts of nutraceutical and/or pharmaceutical interest. MF poly(vinylidene fluoride (PVDF hollow fibers were prepared by the dry/wet spinning technique. A series of fibers was produced from the same polymeric dope, in order to investigate the effect of selected spinning parameters, i.e., bore fluid composition and flowrate, on their properties. The morphology of the produced fibers was analyzed by Scanning Electron Microscopy (SEM. Fibers were further characterized for their mechanical properties, porosity, bubble point, pore size distribution and pure water permeability (PWP. Some of the produced fibers exhibited high permeability (pure water permeability ~530 L/m2·h·bar, coupled to good mechanical resistance and pore size in the range of MF membranes. These fibers were selected and used for the clarification of press liquor from orange peel processing. In optimized operating conditions, the selected fibers produced steady-state fluxes of about 41 L/m2·h with rejections towards polyphenols and total antioxidant activity of 4.1% and 1.4%, respectively.

  17. Mechanical Properties of Copper Processed by Equal Channel Angular Pressing

    Science.gov (United States)

    Sülleiová, K.; Ballóková, B.; Besterci, M.; Kvačkaj, T.

    2017-12-01

    The development of the nanostructure in commercial pure copper and the strength and ductility after severe plastic deformation (SPD) with the technology of equal channel angular pressing (ECAP) are analysed. Experimental results and analyses showed that both strength and ductility can be increased simultaneously by SPD. The final grain size decreased from the initial 50μm by SPD to 100-300 nm after 10 passes. An increase of the ductility together with an increase of strength caused by SPD are explained by a strong grain refinement and by a dynamic equilibrium of weakening and strengthening, and it is visible on the final static tensile test stress-strain charts.

  18. NIC (Nuclear Industry in China) exhibition. Press file

    International Nuclear Information System (INIS)

    1998-01-01

    Framatome participated to the NIC exhibition which took place in Beijing (China) on March 1998. This press dossier was distributed to visitors. It presents in a first part the activities of the Framatome group in people's republic of China (new constructions (Daya Bay, Ling Ao project), technological cooperation and contracts in the nuclear domain, technology transfers in the domain of nuclear fuels, activities and daughter companies in the domain of industrial equipments, Framatome Connectors International (FCI) daughter company in the domain of connectors engineering). Then, the general activities of Framatome in the nuclear, industrial equipment, and connectors engineering domains are summarized in the next 3 parts. (J.S.)

  19. The pressing energy innovation challenge of the US National Laboratories

    Science.gov (United States)

    Anadon, Laura Diaz; Chan, Gabriel; Bin-Nun, Amitai Y.; Narayanamurti, Venkatesh

    2016-10-01

    Accelerating the development and deployment of energy technologies is a pressing challenge. Doing so will require policy reform that improves the efficacy of public research organizations and strengthens the links between public and private innovators. With their US$14 billion annual budget and unique mandates, the US National Laboratories have the potential to critically advance energy innovation, yet reviews of their performance find several areas of weak organizational design. Here, we discuss the challenges the National Laboratories face in engaging the private sector, increasing their contributions to transformative research, and developing culture and management practices to better support innovation. We also offer recommendations for how policymakers can address these challenges.

  20. Press Manipulation and Its Negative Impact on the Youth

    Directory of Open Access Journals (Sweden)

    Ioana Manea

    2010-12-01

    Full Text Available Nowadays, manipulation may be regarded as an essential instrument of the “mass industrial society”, aiming at the conclusion of certain agreements that are convenient to the issuing party, turning to deceit with falsified arguments, as well as to appeals to emotional or non-rational components. The particular forms that it takes in various fields of social life may be found anywhere, from the political form to the economic one. Press strategies have the capacity of manipulating the young consumer’s behaviour, generating numerous negative effects on their everyday life.

  1. Clay characterization for making pressed and burned blocks

    International Nuclear Information System (INIS)

    Alexandre, J.; Silva, C.L. de A.P. e

    2012-01-01

    The municipality of Campos dos Goytacazes, located in the state of Rio de Janeiro, at 275 km from the capital, are the largest industrial ceramic state and he has over 100 unionized industries. The production of these industries is based on tiles, building blocks and bricks. Seeking the improvement and diversification of production, the North Fluminense State University has 18 years working in partnership with local industry, with students and teachers. One of the researches is the production of blocks pressed and burned. In this work are presented in many lab tests performed, morphology and some of technological properties. (author)

  2. [Cigarette and alcohol advertising in the Swiss free press].

    Science.gov (United States)

    Olivier, Jacques

    2014-11-26

    Tobacco and alcohol are ordinary consumer goods that are still two overriding preventable causes of death in Switzerland. Massive advertising supports their selling and contributes to maintain a major public health problem up to date. The widely read free press represents an interesting advertising mean. The study of tobacco and alcohol advertisements published in the free newspaper 20 minutes through the year 2012 gives us a good idea of these products' advertising strategies. Compared to those for alcohol, the cigarette advertisements are more numerous, more suggestive and dealing with emotions. The themes proposed respond to young people's expectations in order to incline them to smoke, whereas positive images encourage to keep on smoking.

  3. Hot pressing of uranium nitride and mixed uranium plutonium nitride

    International Nuclear Information System (INIS)

    Chang, J.Y.

    1975-01-01

    The hot pressing characteristics of uranium nitride and mixed uranium plutonium nitride were studied. The utilization of computer programs together with the experimental technique developed in the present study may serve as a useful purpose of prediction and fabrication of advanced reactor fuel and other high temperature ceramic materials for the future. The densification of nitrides follow closely with a plastic flow theory expressed as: d rho/ dt = A/T(t) (1-rho) [1/1-(1-rho)/sup 2/3/ + B1n (1-rho)] The coefficients, A and B, were obtained from experiment and computer curve fitting. (8 figures) (U.S.)

  4. STS-114: Discovery Crew Post Landing Press Briefing

    Science.gov (United States)

    2005-01-01

    The crew of the STS-114 Discovery is shown during a post landing press briefing. Commander Collins introduces the crew members who consist of Pilot Jim Kelley, Mission Specialist Soichi Noguchi from JAXA, Steve Robinson, Mission Specialist and Charlie Camarda, Mission Specialist. Steve Robinson answers a question from the news media about the repair that he performed in orbit, and his feelings about being back in his hometown of California. Commander Collins talks about the most significant accomplishment of the mission. The briefing ends as each crewmember reflects on the Space Shuttle Columbia tragedy and expresses their personal thoughts and feelings as they re-entered the Earth's atmosphere.

  5. Dynamic balance abilities of collegiate men for the bench press.

    Science.gov (United States)

    Piper, Timothy J; Radlo, Steven J; Smith, Thomas J; Woodward, Ryan W

    2012-12-01

    This study investigated the dynamic balance detection ability of college men for the bench press exercise. Thirty-five college men (mean ± SD: age = 22.4 ± 2.76 years, bench press experience = 8.3 ± 2.79 years, and estimated 1RM = 120.1 ± 21.8 kg) completed 1 repetition of the bench press repetitions for each of 3 bar loading arrangements. In a randomized fashion, subjects performed the bench press with a 20-kg barbell loaded with one of the following: a balanced load, one 20-kg plate on each side; an imbalanced asymmetrical load, one 20-kg plate on one side and a 20-kg plate plus a 1.25-kg plate on the other side; or an imbalanced asymmetrical center of mass, 20-kg plate on one side and sixteen 1.25-kg plates on the other side. Subjects were blindfolded and wore ear protection throughout all testing to decrease the ability to otherwise detect loads. Binomial data analysis indicated that subjects correctly detected the imbalance of the imbalanced asymmetrical center of mass condition (p[correct detection] = 0.89, p < 0.01) but did not correctly detect the balanced condition (p[correct detection] = 0.46, p = 0.74) or the imbalanced asymmetrical condition (p[correct detection] = 0.60, p = 0.31). Although it appears that a substantial shift in the center of mass of plates leads to the detection of barbell imbalance, minor changes of the addition of 1.25 kg (2.5 lb) to the asymmetrical condition did not result in consistent detection. Our data indicate that the establishment of a biofeedback loop capable of determining balance detection was only realized under a high degree of imbalance. Although balance detection was not present in either the even or the slightly uneven loading condition, the inclusion of balance training for upper body may be futile if exercises are unable to establish such a feedback loop and thus eliciting an improvement of balance performance.

  6. Tribologic analysis and technical innovation for rotary molding press

    International Nuclear Information System (INIS)

    Luo Wei; Bai Yumeng; Dai Xingjian

    2012-01-01

    The rotary molding press R53C-Y is the key facility in the compression molding working procedure of the nu clear fuel pellets. Its main compression assembly called the upper compression roller frame has been worn seriously during the production. At first, the mechanical model of the upper compression roller assembly was established for analysis and calculation physical strength. Then the wear causations of the upper compression roller frame were analyzed, and the existent problems of central lubrication system were discussed. Finally, Oil-air central lubrication system was designed considering the characteristic of nuclear fuel pellets production. (authors)

  7. Kustomoitu responsiivinen WordPress-sivusto suomalaiselle Toisenlainen-elokuvalle

    OpenAIRE

    Räsänen, Kati

    2016-01-01

    Opinnäytetyö kertoo Toisenlainen-nimiselle suomalaiselle elokuvalle toteutetusta verkkosivuprojektista. Sivuston pohjana käytettiin WordPress-sisällönhallintajärjestelmää ja sivuston teossa huomioitiin sen skaalautuvuus sekä käytettävyys eri päätelaitteilla. Tutkimusraportissa käsitellään myös tarkemmin responsiivista verkkosivukehitystä sekä sitä, millaisia uusia ajatus- ja toimintamalleja se verkkosivujen tekijöiltä vaatii. Lisäksi raportissa käydään läpi responsiiviseen kehitykseen lii...

  8. 'Combating' tropical diseases in the German colonial press.

    Science.gov (United States)

    Correa, Sílvio Marcus de Souza

    2013-03-01

    This article shows how much certain German language newspapers were a vehicule for reporting to the lay public on 'combating' tropical diseases. Through the press, immigrants and their descendents in Brazil were informed not only about the diseases which afflicted German colonists in Africa, but also about measures concerning sanitation, prophylaxis and experiments with tropical medicine, etc. Based on hemerographic sources, it shows how successful the overseas German communities were in sharing their experiences regarding health in tropical and/or sub-tropical regions.

  9. FILMING OF 'CONTACT' AT LC39 PRESS SITE

    Science.gov (United States)

    1997-01-01

    Warner Bros.' cast and crew are filming scenes for the movie 'Contact' at Kennedy Space Center's Launch Complex 39 Press Site on January 30. The screenplay for 'Contact' is based on the best- selling novel by the late astronomer Carl Sagan. The cast includes Jodie Foster, Matthew McConaughey, John Hurt, James Woods, Tom Skerritt, David Morse, William Fichtner, Rob Lowe and Angela Bassett. Described by Warner Bros. as a science fiction drama, 'Contact' will depict humankind's first encounter with evidence of extraterrestrial life.

  10. The chemical component dictionary: complete descriptions of constituent molecules in experimentally determined 3D macromolecules in the Protein Data Bank.

    Science.gov (United States)

    Westbrook, John D; Shao, Chenghua; Feng, Zukang; Zhuravleva, Marina; Velankar, Sameer; Young, Jasmine

    2015-04-15

    The Chemical Component Dictionary (CCD) is a chemical reference data resource that describes all residue and small molecule components found in Protein Data Bank (PDB) entries. The CCD contains detailed chemical descriptions for standard and modified amino acids/nucleotides, small molecule ligands and solvent molecules. Each chemical definition includes descriptions of chemical properties such as stereochemical assignments, chemical descriptors, systematic chemical names and idealized coordinates. The content, preparation, validation and distribution of this CCD chemical reference dataset are described. The CCD is updated regularly in conjunction with the scheduled weekly release of new PDB structure data. The CCD and amino acid variant reference datasets are hosted in the public PDB ftp repository at ftp://ftp.wwpdb.org/pub/pdb/data/monomers/components.cif.gz, ftp://ftp.wwpdb.org/pub/pdb/data/monomers/aa-variants-v1.cif.gz, and its mirror sites, and can be accessed from http://wwpdb.org. jwest@rcsb.rutgers.edu. Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  11. Preparation and microstructure of hot-pressed YIG

    International Nuclear Information System (INIS)

    Abdul Halim Shaari; Mansor Hashim; Sidek Haji Abd Aziz

    1992-01-01

    Bulk magnetic ceramics such as yttrium-iron-garnet (YIG) and nickel-zinc ferrite were prepared by the conventional-firing and hot-press techniques. Pre-sintering and sintering, both in air, were carried out at temperature ≥ 1200 0 C. Initial density and microstructural measurements show that the high density samples with uniform grain size can be readily achieved by hot-pressing. The well-defined microstructures, the high density attained. The agreement of saturation magnetization 4πMs values and the high resistivities indicated that the optimized preparation conditions for conventional firing yielded yttrium-iron-garnet of good quality. Quenched and isochronally annealed, the YIG samples were also found to retain their room-temperature saturation-magnetization and resonance linewidth values after any single heat treatment. However, the electrical resistivity and the effective linewidth clearly exhibited isochronal recovery. A possible model to explain this behaviour and its implications on microwave applications are discussed. Ferrites of the type MFe 2 O 4 where M=Mg, Mn, Co, Fe, Cu, Zn and Cd and of the type Ni1-2xSnxFe 2 O4 have also been prepared and their properties are being studied

  12. Climate change and daily press : Italy vs Usa parallel analysis

    International Nuclear Information System (INIS)

    Borrelli, G.; Mazzotta, V.; Falconi, C.; Grossi, R.; Farabollini, F.

    1996-06-01

    Among ENEA (Italian National Agency for New Technologies, Energy, and the Environment) activities, one deals with analysis and strategies of environmental information. A survey of four daily newspaper coverage, on an issue (Global Climate Change) belonging to this area, has been realized. The involved newspapers are: two Italian ones, namely 'La Repubblica' and 'Il Corriere della Sera', two North-American ones, namely 'New York Times' and 'Washington Post'. Purpose of the work was that of detecting the qualitative and quantitative level of consciousness of the Italian press via a comparison with the North-American press, notoriously sensible and careful on environmental issues. The number of articled analyzed is partitioned in the following numerical data: 319 for the 'New York Times', 309 for the 'Washington Post', 146 for the 'Corriere della Sera', 81 articles for 'La Repubblica'. The time period covered for the analysis spans from 1989, initiatic year for the organization of the 1992 Rio Conference, to December 1994, deadline date for the submission of national

  13. Treatment of zircaloy cladding hulls by isostatic pressing

    International Nuclear Information System (INIS)

    Tegman, R.; Burstroem, M.

    1984-12-01

    A method for the treatment of Zircaloy fuel hulls is proposed. It involves hot isostatic pressing (HIP) for making large, completely densified metallic bodies of the waste. The hulls are packed into a bellows-shaped container of steel. On packing the fuel hulls give a filling factor of only 14%, which is too low for non-deformable compaction in a normal container, but by using a belloped container, a non-deformable compaction can be obtained without any pretreatment of the hulls. Fully dense and mechanically strong blocks of Zircaloy can be fabricated by holding them at temperatures of around 1000 degrees C for three hours. It is also feasible to incorporate the other metallic parts of the fuel bundle, such as top and bottom tie plates and spacers, in the pressing. The HIP-densified hulls provide an effective means of self-containment of radioactive waste due to the excellent corrosion resistance of Zircaloy. A waste loading factor of close to 100% can be realized. Futher, a volume reduction factor of 7 and a surface reduction factor of aout 250 for a 1-ton canister can be achieved. Equilibrium calculations have shown that tritium present in the hulls can quantitatively be contained in the HIPed block. A study has been made of a possible process for industrilscale use. (Author)

  14. Diachronic changes in word probability distributions in daily press

    Directory of Open Access Journals (Sweden)

    Stanković Jelena

    2006-01-01

    Full Text Available Changes in probability distributions of individual words and word types were investigated within two samples of daily press in the span of fifty years. Two samples of daily press were used in this study. The one derived from the Corpus of Serbian Language (CSL /Kostić, Đ., 2001/ that covers period between 1945. and 1957. and the other derived from the Ebart Media Documentation (EBR that was complied from seven daily news and five weekly magazines from 2002. and 2003. Each sample consisted of about 1 million words. The obtained results indicate that nouns and adjectives were more frequent in the CSL, while verbs and prepositions are more frequent in the EBR sample, suggesting a decrease of sentence length in the last five decades. Conspicuous changes in probability distribution of individual words were observed for nouns and adjectives, while minimal or no changes were observed for verbs and prepositions. Such an outcome suggests that nouns and adjectives are most susceptible to diachronic changes, while verbs and prepositions appear to be resistant to such changes.

  15. Gender violence news in British and American press

    Directory of Open Access Journals (Sweden)

    Sara Bustinduy

    2016-03-01

    Full Text Available This study aims to prove which qualities, from the British and United States actual press, are more adequate for gender violence issues, comparing news on the same stories. It is evident the influence of mass media on public opinion and, therefore, the responsibility that written press has on gender violence messages, avoiding sensationalism. Psycholinguistic studies have established the relation language-thought, so language used in journalism is crucial. Following the belief that newspapers considered more liberal and independent will lead to a better treatment than traditional ones considered to be more reluctant to change, journals have been selected. Furthermore, different cultures can be as objective and respectful but maybe less committed with the issue, as it may arise from the samples. There have been emerging ethic codes giving guidelines to journalists, including discrimination, and more specific on gender sensitive reporting. Therefore, the objective to improve public opinion information, stepping away from stereotypes and oversimplifications, is substantial, and will undoubtedly result in a better understanding of equality.

  16. Incineration ashes conditioning by isostatic pressing and melting

    International Nuclear Information System (INIS)

    Jouan, A.; Ouvrier, N.; Teulon, F.

    1990-01-01

    Alpha-bearing solid incineration wastes are conditioned for two principal reasons: to enhance the quality of the finished product for long-term storage, and to reduce the total waste volume. Isostatic pressing parameters were defined using containers 36 mm in diameter; the physicochemical properties of the compacted ashes were determined with 140 mm diameter containers and industrial feasibility was demonstrated with a large (300 mm diameter) container. Two types of ashes were used: ashes fabricated at Marcoule (either in devices developed by the CEA for the MELOX project with a standard MELOX composition, or by direct incineration at COGEMA's UP1 plant) and fly ash from a domestic waste incinerator. A major engineering study was also undertaken to compare the three known ash containment processes: isostatic pressing, melting, and cement-resin matrix embedding. The flowsheet, operational chronology and control principles were detailed for each process, and a typical plant layout was defined to allow comparisons of both investment and operating costs

  17. Effects of different vibration exercises on bench press.

    Science.gov (United States)

    Marín, P J; Torres-Luque, G; Hernández-García, R; García-López, D; Garatachea, N

    2011-10-01

    This study was undertaken to analyze the effects of different vibration recovery strategies via feet or hands on the number of repetitions performed and on mean velocity, peak velocity and blood lactate concentration during consecutive bench-press sets. 9 elite judo athletes performed 3 sets of bench press at 60% of one-repetition maximum (1RM), leading to failure and allowing a 180 s rest period between sets. During the rest period, 1 of the 3 following procedures was performed: 150 s rest plus 30 s push-up vibration exercise (Push-up), 150 s rest plus 30 s squat vibration exercise (Squat) or 180 s only rest (Passive). Statistical analysis revealed that the Squat condition resulted in a significant increase in the number of repetitions achieved, in comparison with all other rest strategies. However, kinematic parameters and blood lactate concentration were not affected by vibration. These data suggest that a vibration stimulus applied to the feet, between sets, can result in positive improvements in upper body resistance exercise performance. Although the mechanisms are not fully understood, this positive effect of vibration could be due to an increased motor cortex excitability and voluntary drive. © Georg Thieme Verlag KG Stuttgart · New York.

  18. Kennedy Space Center Press Site (SWMU 074) Interim Measure Report

    Science.gov (United States)

    Applegate, Joseph L.

    2015-01-01

    This report summarizes the Interim Measure (IM) activities conducted at the Kennedy Space Center (KSC) Press Site ("the Press Site"). This facility has been designated as Solid Waste Management Unit 074 under KSC's Resource Conservation and Recovery Act Corrective Action program. The activities were completed as part of the Vehicle Assembly Building (VAB) Area Land Use Controls Implementation Plan (LUCIP) Elimination Project. The purpose of the VAB Area LUCIP Elimination Project was to delineate and remove soil affected with constituents of concern (COCs) that historically resulted in Land Use Controls (LUCs). The goal of the project was to eliminate the LUCs on soil. LUCs for groundwater were not addressed as part of the project and are not discussed in this report. This report is intended to meet the Florida Department of Environmental Protection (FDEP) Corrective Action Management Plan requirement as part of the KSC Hazardous and Solid Waste Amendments permit and the U.S. Environmental Protection Agency's (USEPA's) Toxic Substance Control Act (TSCA) self-implementing polychlorinated biphenyl (PCB) cleanup requirements of 40 Code of Federal Regulations (CFR) 761.61(a).

  19. Muscle synergies during bench press are reliable across days.

    Science.gov (United States)

    Kristiansen, Mathias; Samani, Afshin; Madeleine, Pascal; Hansen, Ernst Albin

    2016-10-01

    Muscle synergies have been investigated during different types of human movement using nonnegative matrix factorization. However, there are not any reports available on the reliability of the method. To evaluate between-day reliability, 21 subjects performed bench press, in two test sessions separated by approximately 7days. The movement consisted of 3 sets of 8 repetitions at 60% of the three repetition maximum in bench press. Muscle synergies were extracted from electromyography data of 13 muscles, using nonnegative matrix factorization. To evaluate between-day reliability, we performed a cross-correlation analysis and a cross-validation analysis, in which the synergy components extracted in the first test session were recomputed, using the fixed synergy components from the second test session. Two muscle synergies accounted for >90% of the total variance, and reflected the concentric and eccentric phase, respectively. The cross-correlation values were strong to very strong (r-values between 0.58 and 0.89), while the cross-validation values ranged from substantial to almost perfect (ICC3, 1 values between 0.70 and 0.95). The present findings revealed that the same general structure of the muscle synergies was present across days and the extraction of muscle synergies is thus deemed reliable. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Means of temporal expressions in newspaper news and press report

    Directory of Open Access Journals (Sweden)

    Čutura Ilijana R.

    2016-01-01

    Full Text Available This paper analyses most frequent linguistic means for expressing the temporal frame in the printed news and press reports. With structuralism as a chosen theoretical framework, the approach of the research is qualitative and stylistic. Since the study belongs to the field of functional stylistics, the primary methods used in the study were functional-stylistic and linguistic-stylistic ones. As the study focuses on two newspaper genres, comparative-stylistic method was used as well. The analysis has been conducted on concrete linguistic excerpts from Serbian daily newspapers published throughout Serbia from 2008 to 2015. The aims of the paper are to show model of expressing temporal frame in contemporary Serbian newspapers. This paper provides an overview of the characteristics of model and the types of temporal expression as well as their variations in contemporal Serbian newspapers. The paper also aims to determine the differencies between printed news and press reports by the choice of temporal expressions. It is shown that there is a tendency of changing schematized structure of these informative genres and some innovation in relation to the choice of linguistic means for expessing the meaning of temporally close events. The research is a contribution to journalism stylistics, more precisely to the Serbian language newspaper stylistics, and also contributes to the study of linguistic and stylistic characteristics of non-literary texts. The study is also relevant because it describes the use of adverbs and adverbial expressions in the journalistic style.

  1. Feasibility of tailoring of press formed thermoplastic composite parts

    Science.gov (United States)

    Sinke, J.

    2018-05-01

    The Tailor Made Blank concept is widely accepted in the production of sheet metal parts. By joining, adding and subtracting materials, and sometimes even applying different alloys, parts can be produced more efficiently by cost and/or weight, and new design options have been discovered. This paper is about the manufacture of press formed parts of Fibre Reinforced Thermoplastics and the evaluation whether the Tailoring concept, though adapted to the material behavior of FRTP, can be applied to these composites as well. From research, the first results and ideas are presented. One of the ideas is the multistep forming process, creating parts with thickness variations and combinations of fibre orientations that are usually not feasible using common press forming strategies. Another idea is the blending of different prepreg materials in one component. This might be useful in case of specific details, like for areas of mechanical fastening or to avoid carbon/metal contact, otherwise resulting in severe corrosion. In a brief overview, future perspectives of the potential of the Tailoring concept are presented.

  2. Precision Force Control for an Electro-Hydraulic Press Machine

    Directory of Open Access Journals (Sweden)

    Hong-Ming Chen

    2014-08-01

    Full Text Available This thesis is primarily intended to design a PC-based control system to control the force of an electro-hydraulic servo press system for implementing precision force control. The main feature is to develop a composite control by using the relief valve and the flow servo valve. Using feedback from a force sensor, a fuzzy controller was designed with LabVIEW software as the system control core for achieving a precision force control for the hydraulic cylinder on its travel and output. The weakness of hydraulic systems is that hydraulic oil is compressible and prone to leaking, and its characteristics can vary with oil temperature, thus making it difficult for a general linear controller to achieve accurate control. Therefore, a fuzzy controller was designed with LabVIEW along with a NI-PCI_6221 interface card and a load cell to control the servo valve flow and the relief valve to control the pressure source. The testing results indicate that accurate force control output of an electro-hydraulic servo press system can be obtained.

  3. Human Rights and Consership in the Portuguese Press

    Directory of Open Access Journals (Sweden)

    Isabel Salema Morgado

    2007-06-01

    Full Text Available This article analyzes the censorship system existing in Portugal in the XVIII century, when a rigid jurisdiction with respect to press freedom was instituted by Portuguese State and how “Gazeta de Lisboa” succeeded in informing its public about the revolutionary events that took place in France during the year of 1789. Many years after that, in 1948, other important event – the Universal Declaration of Human Rights approved by the United Nations General Assembly, did not receive the attention of Portuguese Press. Of the 15 newspapers and magazines with wider circulation that were consulted, only three published the news of the approval. Also I did not fi nd in any of the archives documents which proved the exercising of censorship or punishment, by the dictatorial regime of Salazar, in the form of disciplinary processes against the newspapers with relation to the publication of news referring to the Declaration. I am inclined toward the theory of the act of self-censorship imposed by the editor on himself, in both events.

  4. LSA glass-ceramic tiles made by powder pressing

    International Nuclear Information System (INIS)

    Figueira, F.C.; Bertan, F.M.; Riella, H.G.; Uggioni, E.; Bernardin, A.M.

    2009-01-01

    A low cost alternative for the production of glass-ceramic materials is the pressing of the matrix glass powders and its consolidation simultaneously with crystallization in a single stage of sintering. The main objective of this work was to obtain LSA glass ceramics with low thermal expansion, processed by pressing and sintering a ceramic frit powder. The raw materials were homogenized and melted (1480 deg C, 80min), and the melt was poured in water. The glass was chemically (XRF and AAS) and thermally (DTA, 10 deg C/min, air) characterized, and then ground (60min and 120min). The ground powders were characterized (laser diffraction) and compressed (35MPa and 45MPa), thus forming four systems. The compacts were dried (150 deg C, 24h) and sintered (1175 deg C and 1185 deg C, 10 deg C/min). Finally, the glass-ceramics were characterized by microstructural analysis (SEM and XRD), mechanical behavior (σbending) and thermal analysis (α). The best results for thermal expansion were those for the glass-ceramics processed with smaller particle size and greater compaction pressure. (author)

  5. Does community participation set the local press agenda? A view on deliberative and civic practices in the Portuguese press

    OpenAIRE

    Ferreira, Gil Baptista

    2013-01-01

    What are journalists’ perceptions of the citizen’s role in democratic life? What is the role that journalists attribute to the public in the construction of the news agenda? The main goal of this study is to investigate the relationship between the local press, citizens and civic practices. It takes as starting point a dual theoretical approach, the theory of deliberative democracy and the public journalism movement, to assess the scope of the concept of “deliberative journalism.” Under the a...

  6. Ireland’s Press Ombudsman, John Horgan, on accountability, regulation and redress: Where do press councils stand?

    OpenAIRE

    Horgan, John

    2012-01-01

    In recent years, the creation of a number of press councils in Europe and elsewhere, as well as the concurrent appointment of internal ombudsmen or readers’ representatives in many significant newspapers, particularly in the United States, is a clear response to a growing public perception that there is a need for an appropriate level of accountability for the print media. It is fair to assume that this is related, in part, to a public perception that there is a need for remedies for abuses o...

  7. Paleovegetation changes recorded by n-alkyl lipids bound in macromolecules of plant fossils and kerogens from the Cretaceous sediments in Japan

    Science.gov (United States)

    Miyata, Y.; Sawada, K.; Nakamura, H.; Takashima, R.; Takahashi, M.

    2014-12-01

    Resistant macromolecules composing living plant tissues tend to be preserved through degradation and diagenesis, hence constituate major parts of sedimentary plant-derived organic matter (kerogen), and their monomer compositions vary widely among different plant taxa, organs and growth stages. Thus, analysis of such macromolecule may serve as new technique for paleobotanical evaluation distinctive from classical paleobotnical studies depends on morphological preservation of fossils. In the present study, we analyzed plant fossils and kerogens in sediments from the Cretaceous strata in Japan to examine chemotaxonomic characteristics of fossil macromolecules and to reconstruct paleovegetation change by kerogen analysis. The kerogens were separated from the powdered sediments of Cretaceous Yezo Group, Hokkaido, Japan. All kerogens have been confirmed to be mostly originated from land plant tissues by microscopic observation. Mummified angiosperm and gymnosperm fossil leaves were separated from carbonaceous sandstone of the Cretaceous Ashizawa Formation, Futaba Group. The kerogens and plant fossils were extracted with methanol and dichloromethane, and were subsequently refluxed under 110°C to remove free compounds completely. The residues are hydrolyzed by KOH/methanol under 110°C. These released compounds are analyzed by GC-MS. As main hydrolyzed products (ester-bound molecular units) from all kerogens, C10-C28 n-alkanoic acids and C10-C30 n-alkanols were detected. Recent studies on the hydrolysis products of plant tissues suggested the long chain (>C20) n-alkanols were predominantly abundant in deciduous broadleaved angiosperms. Correspondingly, the stratigraphic variation of the ratios of long chain (>C20) n-alkanols to fatty acids was concordant with the variation of angiosperm/gymnosperm ratios recorded by land plant-derived terpenoid biomarkers. In addition, we found that the long chain n-alkanols/fatty acids ratio in the angiosperm fossil leaf was

  8. International Commercial Contracts, by Giuditta Cordero Moss. (Cambridge: Cambridge University Press, 2014)

    DEFF Research Database (Denmark)

    Lando, Ole

    2015-01-01

    Review of: Giuditta Cordero Moss, International Commercial Contracts. Cambridge: Cambridge University Press, 2014. XV + 329 pages. ISBN: 9781107684713......Review of: Giuditta Cordero Moss, International Commercial Contracts. Cambridge: Cambridge University Press, 2014. XV + 329 pages. ISBN: 9781107684713...

  9. Reporters on the Battlefield. The Embedded Press System in Historical Context

    National Research Council Canada - National Science Library

    Paul, Christopher; Kim, James J

    2004-01-01

    While the history of relations between the press and the military predates modern journalism, much of what had gone before was neutralized by the horrible press-military breakdown that occurred during U.S...

  10. A Comparison of Coverage of Speech and Press Verdicts of Supreme Court.

    Science.gov (United States)

    Hale, F. Dennis

    1979-01-01

    An analysis of the coverage by ten newspapers of 20 United States Supreme Court decisions concerning freedom of the press and 20 decisions concerning freedom of speech revealed that the newspapers gave significantly greater coverage to the press decisions. (GT)

  11. Pressing and tubes rolling out of tungsten of gas phase deposition

    International Nuclear Information System (INIS)

    Korolev, Yu.M.; Kosachev, L.S.; Semiletov, S.S.; Solov'ev, V.F.; Sorkin, V.A.

    1987-01-01

    The possibility of increasing ductility of tubes of tungsten fluoride using heat treatment and plastic deformation- pressing and thermal rolling are studied. When designing the processes of treatment it should be necessarily taken into account that structural state of initial blanks as well as the ratio of deformations in radial and tangential directions under pressing with a rigid needle strongly affects technological properties of pressed tubes. The columnar structure of blanks is undesirable for its embrittlement affects the pressed tubes

  12. Fabrication of fully ceramic microencapsulated fuel by hot pressing

    International Nuclear Information System (INIS)

    Lee, H. G.; Kim, D. J; Park, J. Y.; Kim, W. J.; Lee, S. J

    2014-01-01

    Fully ceramic microencapsulated(FCM) nuclear fuel is one of the recently suggested concept to enhance stability nuclear fuel itself. The requirements to increase the accident tolerance of nuclear fuel are mainly two parts: First, the performance has to be maintained compared to the existing UO 2 nuclear fuel and zircaloy cladding system under the normal operation condition. Second, under the severe accident condition, the high temperature structural integrity has to be kept and the generation rate of hydrogen has to be decrease largely. FCM nuclear fuel consists of tristructural isotropic(TRISO) fuel particle and SiC matrix. The relative thermal conductivity of the SiC matrix as compared to UO 2 is quite good, yielding as-irradiated fuel centerline temperature compared to high temperature for the existing fuel leading to reduced stored energy in the core and reduced operational release of fission products from the fuel. Generally SiC ceramics are fabricated via liquid phase sintering due to strong covalent bonding property and low self-diffusivity coefficient. Hot pressing is very effective method to conduct sintering of SiC powder including different second phase. In this study, SiC-matrix composite including TRISO particles were sintered by hot pressing with Al 2 O 3 -Y 2 O 3 additive system. Various sintering condition were investigated to obtain high relative density above 95%. The internal distribution of TRISO particles within SiC-matrix composite was observed by x-ray radiograph. From the analysis of the cross-section of SiC-matrix composite, the fracture of TRISO particles was investigated. In order to uniform distribution of TRISO particle embedded in the SiC matrix, SiC powder overcoating is considered. SiC matrix composite including TRISO was fabricated by hot pressing. FCM pallets with full density were obtained with Al 2 O 3 -Y 2 O 3 additive system. From the microstructure image, the effect of the sintering additive contents and sintering mechanism

  13. The use of anomalous scattering of uranium for the determination of biological macromolecules structures - From hard to soft X-rays

    International Nuclear Information System (INIS)

    Chesne-Seck, M.L.

    2002-01-01

    In order to solve biological macromolecules structures, structure factor phases must be derived from the intensities diffracted by the crystal. The SAD and the MAD methods make use of variations in scattering factors measured at specific absorption edges of heavy atoms, bound to the protein. The phasing power depends on the occupancy of the binding sites and on the variations of the scattering factors at the absorption edge that is used. With uranyl, numerous sites with low occupancies are usually obtained. We used new colored uranyl complexes, which give higher occupancies, to solve de novo the lysozyme structure and an unknown structure. We have developed the use of the My absorption edge of uranium (λ = 3,5 Angstroms), where a variation of 120 electrons is observed in the scattering factors. With a helium atmosphere to limit the X-rays absorption, we have collected three data sets, on a single image. Data were processed both with 'classical' and specific programs. (author) [fr

  14. Water-resistance of macromolecules adsorbed on CH3NH3PbI3 surfaces: A first-principles study

    Science.gov (United States)

    Chen, Po-Tuan; Yung, Tung-Yuan; Liu, Ting-Yu; Sher, Chin-Wei; Hayashi, Michitoshi

    2017-10-01

    Encapsulation within resin films is a promising approach for isolating perovskite materials from water. To gain fundamental insight into these systems, we performed first-principles calculations of macromolecule (polymerized siloxane; epoxy cured by phthalic anhydride; graphene sheet) coatings for the waterproofing of methylammonium lead iodide perovskite (MAPbI3) surfaces. Our calculations reveal that alternating attractive/resistant functional groups on the siloxane- or epoxy-modified MAPbI3 surfaces hinder the water diffusion process. Moreover, we examined a no-defect graphene sheet for its ability to isolate MAPbI3 from water molecules. The hydrophobicity of the graphene resulted in water molecules forming clusters, rather than dispersing, upon the sheet.

  15. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease

    DEFF Research Database (Denmark)

    Parlesak, Alexandr; Schäfer, C.; Schütz, Tanja

    2000-01-01

    BACKGROUND/AIMS: No information is yet available about the influence of alcohol abuse on the translocation of larger molecules (Mr>1200) through the intestinal mucosa in man. The present study aimed to determine the intestinal permeability to macromolecules in patients with chronic alcohol abuse...... and mild to more advanced stages of liver disease, and to measure the concentration of endotoxins in the plasma, as these compounds derive from the intestinal flora and are suspected to contribute to the development of alcoholic liver disease (ALD). METHODS: The permeability to polyethylene glycol Mr 400......, Mr 1500, Mr 4000, and Mr 10,000 and endotoxin plasma concentrations were measured in 54 patients with alcoholic liver disease, 19 of them with cirrhosis, and in 30 non-alcoholic healthy controls. RESULTS: Permeability to polyethylene glycol Mr 400 was found to be unchanged in patients with ALD...

  16. Design and testing of a solar photovoltaic operated multi-seeds oil press

    Energy Technology Data Exchange (ETDEWEB)

    Mpagalile, J.J. [Department of Food Science and Technology, Sokoine University of Agriculture, P.O. Box 3006, Morogoro (Tanzania); Hanna, M.A.; Weber, R. [Industrial Agricultural Products Center, University of Nebraska, 209 L.W. Chase Hall, Lincoln, NE 68583-0730 (United States)

    2006-10-15

    Oil expression tests were conducted to evaluate the performance of a novel oil expeller designed and fabricated to operate on a 200W solar photovoltaic (PV) power system as a sole power source. The oil press was designed to press oilseeds meal with intermediate moisture content of 12+/-1% (w.b.) and 0.5-2mm particle sizes. Freshly grated coconuts and ground peanuts were used to determine the oil expression efficiency of the press. The oilseed samples were pressed for 12min with a maximum pressure of 3.0MPa being reached at 6min of pressing for peanuts and 8min of pressing for coconuts. The pressure was then held for the rest of the pressing time. The press attained an average oil expression efficiency of 73% for coconuts and 70% for peanuts. The force-vs.-deformation studies indicated that peanut press meal was compacted at a higher rate as compared to coconuts. The observation on the energy consumption indicated that there was a significant increase (P<0.05) in the specific energy requirement for both coconuts and peanuts after 6min of pressing, which resulted from the solidification of the press cake. An average specific energy of 36.55 and 20.35Wh/kg was recorded for peanuts and coconuts, respectively, after 12min of pressing. (author)

  17. Pronouncements and Denunciations: An Analysis of State Press Association Ethics Codes from the 1920s.

    Science.gov (United States)

    Cronin, Mary M.; McPherson, James B.

    1995-01-01

    Discusses how four situational concerns (the rise of press agents, the fallout from World War I propaganda, sensationalism's resurgence, and editorial independence) contributed to a noticeable decline of the public's trust in the press. Shows how, as a result, 12 state press association ethics codes from the 1920s consistently emphasized the…

  18. Student Press in American Archives, Fall/Winter 1973-74.

    Science.gov (United States)

    National Council of Coll. Publications Advisers.

    This issue of the "Student Press in America Archives List" contains 100 entries on current issues and information, as well as cases involving student press editors, advisers, student media, and the generic subject of the campus press, emphasizing censorship practices and principles. Information concerning how and where to obtain documents of…

  19. A Low-Cost Auto-Stop Hydraulic Press for Making KBr Disc

    Science.gov (United States)

    Hon, Ping-Kay

    1998-05-01

    A hydraulic press fitted with an adjustable torque wrench, together with a stand made of iron bars will form an auto-stop hydraulic press for making KBr disc in IR studies. Total material cost is about $100. All parts are readily available from the local hardware stores. The modified torque wrench is also useful to replace the lever in the standard laboratory press.

  20. A Simplified Model of an Offset Ram Press for Sunflower Oil ...

    African Journals Online (AJOL)

    This paper presents the theoretical analysis of a simplified model of a ram press. The design of the ram press is based on the classical slider-crank mechanism. A force analysis of the press was performed for several successive positions of the driving lever (handle) and for a range of values of certain dimensionless ...

  1. Type synthesis for 4-DOF parallel press mechanism using GF set theory

    Science.gov (United States)

    He, Jun; Gao, Feng; Meng, Xiangdun; Guo, Weizhong

    2015-07-01

    Parallel mechanisms is used in the large capacity servo press to avoid the over-constraint of the traditional redundant actuation. Currently, the researches mainly focus on the performance analysis for some specific parallel press mechanisms. However, the type synthesis and evaluation of parallel press mechanisms is seldom studied, especially for the four degrees of freedom(DOF) press mechanisms. The type synthesis of 4-DOF parallel press mechanisms is carried out based on the generalized function(GF) set theory. Five design criteria of 4-DOF parallel press mechanisms are firstly proposed. The general procedure of type synthesis of parallel press mechanisms is obtained, which includes number synthesis, symmetrical synthesis of constraint GF sets, decomposition of motion GF sets and design of limbs. Nine combinations of constraint GF sets of 4-DOF parallel press mechanisms, ten combinations of GF sets of active limbs, and eleven combinations of GF sets of passive limbs are synthesized. Thirty-eight kinds of press mechanisms are presented and then different structures of kinematic limbs are designed. Finally, the geometrical constraint complexity( GCC), kinematic pair complexity( KPC), and type complexity( TC) are proposed to evaluate the press types and the optimal press type is achieved. The general methodologies of type synthesis and evaluation for parallel press mechanism are suggested.

  2. The news value of Dutch corporate press releases as a predictor of corporate agenda building power

    NARCIS (Netherlands)

    Schafraad, P.; van Zoonen, W.; Verhoeven, P.

    2016-01-01

    This study focuses on explaining agenda building power of corporate press releases. The purpose of the study is to investigate to what extent news factor theory can be applied to predict whether a press release generates media attention or not. A content analysis of 823 press releases from 30 of the

  3. A Mo-anode-based in-house source for small-angle X-ray scattering measurements of biological macromolecules

    Energy Technology Data Exchange (ETDEWEB)

    Bruetzel, Linda K.; Fischer, Stefan; Salditt, Annalena; Sedlak, Steffen M.; Nickel, Bert; Lipfert, Jan, E-mail: Jan.Lipfert@lmu.de [Department of Physics, Nanosystems Initiative Munich, and Center for Nanoscience, Ludwig-Maximilians-University Munich, Amalienstr. 54, 80799 Munich, Germany and Geschwister-Scholl Platz 1, 80539 Munich (Germany)

    2016-02-15

    We demonstrate the use of a molybdenum-anode-based in-house small-angle X-ray scattering (SAXS) setup to study biological macromolecules in solution. Our system consists of a microfocus X-ray tube delivering a highly collimated flux of 2.5 × 10{sup 6} photons/s at a beam size of 1.2 × 1.2 mm{sup 2} at the collimation path exit and a maximum beam divergence of 0.16 mrad. The resulting observable scattering vectors q are in the range of 0.38 Å{sup −1} down to 0.009 Å{sup −1} in SAXS configuration and of 0.26 Å{sup −1} up to 5.7 Å{sup −1} in wide-angle X-ray scattering (WAXS) mode. To determine the capabilities of the instrument, we collected SAXS data on weakly scattering biological macromolecules including proteins and a nucleic acid sample with molecular weights varying from ∼12 to 69 kDa and concentrations of 1.5–24 mg/ml. The measured scattering data display a high signal-to-noise ratio up to q-values of ∼0.2 Å{sup −1} allowing for an accurate structural characterization of the samples. Moreover, the in-house source data are of sufficient quality to perform ab initio 3D structure reconstructions that are in excellent agreement with the available crystallographic structures. In addition, measurements for the detergent decyl-maltoside show that the setup can be used to determine the size, shape, and interactions (as characterized by the second virial coefficient) of detergent micelles. This demonstrates that the use of a Mo-anode based in-house source is sufficient to determine basic geometric parameters and 3D shapes of biomolecules and presents a viable alternative to valuable beam time at third generation synchrotron sources.

  4. Direct analysis of intact biological macromolecules by low-energy, fiber-based femtosecond laser vaporization at 1042 nm wavelength with nanospray postionization mass spectrometry.

    Science.gov (United States)

    Shi, Fengjian; Flanigan, Paul M; Archer, Jieutonne J; Levis, Robert J

    2015-03-17

    A fiber-based laser with a pulse duration of 435 fs and a wavelength of 1042 nm was used to vaporize biological macromolecules intact from the condensed phase into the gas phase for nanospray postionization and mass analysis. Laser vaporization of dried standard protein samples from a glass substrate by 10 Hz bursts of 20 pulses having 10 μs pulse separation and energy resulted in signal comparable to a metal substrate. The protein signal observed from an aqueous droplet on a glass substrate was negligible compared to either a droplet on metal or a thin film on glass. The mass spectra generated from dried and aqueous protein samples by the low-energy, fiber laser were similar to the results from high-energy (500 μJ), 45-fs, 800-nm Ti:sapphire-based femtosecond laser electrospray mass spectrometry (LEMS) experiments, suggesting that the fiber-based femtosecond laser desorption mechanism involves a nonresonant, multiphoton process, rather than thermal- or photoacoustic-induced desorption. Direct analysis of whole blood performed without any pretreatment resulted in features corresponding to hemoglobin subunit-heme complex ions. The observation of intact molecular ions with low charge states from protein, and the tentatively assigned hemoglobin α subunit-heme complex from blood suggests that fiber-based femtosecond laser vaporization is a "soft" desorption source at a laser intensity of 2.39 × 10(12) W/cm(2). The low-energy, turnkey fiber laser demonstrates the potential of a more robust and affordable laser for femtosecond laser vaporization to deliver biological macromolecules into the gas phase for mass analysis.

  5. Hot isostatic pressing of glass-zeolite composites

    International Nuclear Information System (INIS)

    Hash, M.C.; Pereira, C.; Lewis, M.A.

    1996-01-01

    Glass-zeolite waste forms are being developed for immobilizing the chloride waste salt generated from the electrometallurgical treatment of spent fuel. Glass-zeolite composites with high densities were made using hot isostatic pressing (HIP) techniques. Processing parameters were investigated to yield desirable structural ceramic properties such as mechanical, chemical, and thermal stability. Limits for these parameters were determined by differential thermal and thermogravimetric analysis. The resulting ceramic properties such as bulk density, open or apparent porosity, and leach resistance were determined. In addition, phase equilibria and particle-size distribution were observed by optical light and electron microscopy. Pre-HIP processing techniques were also studied to ensure intimate mixing of the glass and zeolite powders. Particle size distributions resulting from dry blending procedure are appropriate for needed flow and packing characteristics

  6. Ultrafine grained steels processed by equal channel angular pressing

    International Nuclear Information System (INIS)

    Shin, Dong Hyuk; Park, Kyung-Tae

    2005-01-01

    Recent development of ultrafine grained (UFG) low carbon steels by using equal channel angular pressing (ECAP) and their room temperature tensile properties are reviewed, focusing on the strategies overcoming their inherent mechanical drawbacks. In addition to ferrite grain refinement, when proper post heat treatments are imposed, carbon atom dissolution from pearlitic cementite during ECAP can be utilized for microstructural modification such as uniform distribution of nano-sized cementite particles or microalloying element carbides inside UFG ferrite grains and fabrication of UFG ferrite/martensite dual phase steel. The utilization of nano-sized particles is effective on improving thermal stability of UFG low carbon ferrite/pearlite steel but less effective on improving its tensile properties. By contrast, UFG ferrite/martensite dual phase steel exhibits an excellent combination of ultrahigh strength, large uniform elongation and extensive strain hardenability

  7. THE FRAMING OF RARE DISEASES IN SPANISH PRESS

    Directory of Open Access Journals (Sweden)

    Sebastián Sánchez Castillo

    2014-06-01

    Full Text Available The news frame analysis has become a basic tool to understand the cognitive structures that construct social reality in its many facets. The objective of this research is to reveal the basic frames and generic frames that define the treatment of rare diseases in the Spanish press. The content analysis of 216 news items about rare diseases published in El País, El Mundo and ABC from August 2010 to September 2012 has been determined to a large extent the problem is presented as a complex social reality rather than how a disease more. Human interest based on personalization of information is the most important generic framing. These results may contribute to greater social visibility of the Rare Diseases.

  8. Anglicism in the press of Santiago de Cuba city

    Directory of Open Access Journals (Sweden)

    Yusnel Tabares-Tabares

    2017-06-01

    Full Text Available The preliminary findings from an unfinished investigation having a synchronic approach are presented. The objective of this study is to analyze the English loanwords that appear in the press of Santiago de Cuba city at the beginning of the XX century. This analysis will allow to draw significant conclusions concerning the presence of anglicisms in the Spanish spoken in Cuba. The methodology is based on a random revision of “El Cubano Libre” newspaper, at the time it is counted some aspects, namely: how many anglicisms were found, their typology, grammatical category, their frequency of appearance, and the year they were published in the dictionary of the Spanish Royal Academy.  Among the outstanding results is remarkable that few English loanwords were registered in the dictionary of the Spanish Royal Academy, the topics more profitable to search were those of politics and sport, and the sort of anglicisms more frequent belong to the category of patent loanword.

  9. Press conference bring excitement of geophysical research to the public

    Science.gov (United States)

    Leifert, Harvey

    “A Flare to Remember.” “Starbucks for Starfish.” “Earth's Rotation Slows for El Niño.” What do these catchy headlines have in common? They all resulted from presentations at AGU's Spring Meeting in Boston, Mass. Yes, geophysical science can be big news when presented in a way that is interesting to general audiences.Proof? Well, the “Flare to Remember” headline (in the Dallas Morning News) reported the discovery, via the SOHO spacecraft, that a solar flare had produced, deep inside the Sun, seismic disturbances of a magnitude never experienced on Earth. Researchers Valentina Zharkova of Glasgow University and Alexander Kosovichev of Stanford gave media representatives a preview of their session, supported by visual aids, in the AGU press briefing room.

  10. Void formation in ODS EUROFER produced by hot isostatic pressing

    International Nuclear Information System (INIS)

    Ortega, Y.; Monge, M.A.; Castro, V. de; Munoz, A.; Leguey, T.; Pareja, R.

    2009-01-01

    Positron annihilation experiments were performed on oxide dispersion strengthened (ODS) and non-ODS EUROFER prepared by mechanical alloying and hot isostatic pressing. The results revealed the presence of small voids in these materials in the as-HIPed conditions. Their evolution under isochronal annealing experiments was investigated. The coincidence Doppler broadening spectra of ODS EUROFER exhibited a characteristic signature attributed to positron annihilation in Ar-decorated voids at the oxide particle/matrix interfaces. The variation of the positron annihilation parameters with the annealing temperature showed three stages: up to 623 K, between 823 and 1323 K, and above 1323 K. In the temperature range 823-1323 K void coarsening had effect. Above 1323 K some voids annealed out, but others, associated to oxide particles and small precipitates, survived to annealing at 1523 K. Transmission electron microscopy observations were also performed to verify the characteristics of the surviving defects after annealing at 1523 K.

  11. Void formation in ODS EUROFER produced by hot isostatic pressing

    Energy Technology Data Exchange (ETDEWEB)

    Ortega, Y. [Departamento de Fisica, Universidad Carlos III de Madrid, 28911 Leganes (Spain)], E-mail: yanicet@fis.ucm.es; Monge, M.A. [Departamento de Fisica, Universidad Carlos III de Madrid, 28911 Leganes (Spain); Castro, V. de [Department of Materials, University of Oxford, Oxford OX1 3PH (United Kingdom); Munoz, A.; Leguey, T.; Pareja, R. [Departamento de Fisica, Universidad Carlos III de Madrid, 28911 Leganes (Spain)

    2009-04-30

    Positron annihilation experiments were performed on oxide dispersion strengthened (ODS) and non-ODS EUROFER prepared by mechanical alloying and hot isostatic pressing. The results revealed the presence of small voids in these materials in the as-HIPed conditions. Their evolution under isochronal annealing experiments was investigated. The coincidence Doppler broadening spectra of ODS EUROFER exhibited a characteristic signature attributed to positron annihilation in Ar-decorated voids at the oxide particle/matrix interfaces. The variation of the positron annihilation parameters with the annealing temperature showed three stages: up to 623 K, between 823 and 1323 K, and above 1323 K. In the temperature range 823-1323 K void coarsening had effect. Above 1323 K some voids annealed out, but others, associated to oxide particles and small precipitates, survived to annealing at 1523 K. Transmission electron microscopy observations were also performed to verify the characteristics of the surviving defects after annealing at 1523 K.

  12. Cultural Appropriations; Ethnic-Racial Representations; Black Press

    Directory of Open Access Journals (Sweden)

    Maria Angélica Zubaran

    2015-12-01

    Full Text Available This paper investigates the exchange and circulation of ideas in the black diaspora, particularly in the newspaper The Example, mapping and discussing the ethnic-racial and gender representations constructed in the narratives produced by the editors of this newspaper, during the campaign for the construction of a monument to the “Black Mother”. The aim is to analyze how the newspaper’s editors have appropriated texts that circulated in other newspapers about the campaign to the monument of the “Black Mother”, adapted them to their own interests and given them new meanings. From the theoretical approach of Cultural Studies, we understand the black press as a cultural artifact that not only informs but also produces discourses and representations that contribute to the formation of black subjectivities and identities.

  13. Conference/debate on nuclear power. Press file

    International Nuclear Information System (INIS)

    1998-01-01

    This press dossier presents in a digest way the advantages of nuclear power with respect to other energy sources. After a presentation of the worldwide energy resources (electric power demand, fossil-fuel reserves, renewable energies, environmental constraints), the dossier describes the functioning principle of a PWR reactor as a presentation of the French nuclear program (historical aspects, policy, organization of activities, trade, EPR project). In the last part, the sociological aspects of nuclear power are approached: environmental aspects (natural radioactivity, reactors safety, radioactive wastes, environment protection, carbon dioxide and energy production), and public health aspects (principles of radioactivity, dose effects, industrial and scientific applications of radionuclides, nuclear controversy, reactor accidents, legal aspects of radioprotection, safety standards and controls). (J.S.)

  14. Ductility in hot isostatically pressed 250-grade maraging steel

    International Nuclear Information System (INIS)

    German, R.M.; Smugeresky, J.E.

    1978-01-01

    Prealloyed 250-grade maraging steel powder produced by the rotating electrode process was fully consolidated by hot isostatic pressing (HIP) at 1100 and 1200 0 C. The strength following aging (3 h at 480 0 C) equalled that of wrought material; however, ductility was negligible. This lack of ductility in the powder metallurgy product was traced to titanium segregation which occurred at the powder surface during power production. The formation of a titanium intermetallic at the prior particle boundaries during aging caused failure at low plastic strains. Altered aging treatments successfully broke up the embrittling film and resulted in a significant ductility recovery for the HIP material. Analysis of the fracture process indicates that further ductility gains are possible by reducing the titanium content, refining the particle size, and optimizing the thermal cycles

  15. Techniques for hot-press-bonding dissimilar metal combinations

    International Nuclear Information System (INIS)

    Watson, R.D.

    1966-05-01

    High strength diffusionless bonds can be produced in a variety of dissimilar metal combinations by the hot press bonding technique covered by Canadian Patent application 904,548 June 6, 1964. Some of the combinations that can be joined successfully are Zircaloy-2 and 416 stainless steel, 416 stainless steel and mild steel, 1S aluminum and mild steel, Zircaloy-2 and M257 SAP, and Zircaloy-2 and 1S aluminum. Several other combinations were attempted but suitable joints could not be produced. The methods of producing the joints, the joint strength that can be developed and a discussion of some of the problems associated with making the joints are included in the report. (author)

  16. Press briefing on results from the solar spacecraft SOHO

    Science.gov (United States)

    1998-04-01

    After its launch on 2 December 1995, SOHO travelled to take up a special orbit 1.5 million kilometres away on the sunward side of the Earth, where the Sun never sets. The full scientific programme began in April 1996. The occasion for the briefing is the celebration of that second anniversary and of the mission's extension to 2003. Organized by the European Space Agency, the briefing will be hosted by the Rutherford Appleton Laboratory, which is near Oxford. Leading scientists associated with SOHO will announce to the press some remarkable new discoveries about the Sun's interior, atmosphere and solar wind. They will also briefly review the main achievements of the past two years. The role of SOHO as the chief watchdog for storms on the Sun that may affect the Earth will be demonstrated. Europe's creation of the finest spacecraft ever built to observe the Sun will be recalled by a top engineer from ESA. A speaker from NASA will explain transatlantic contributions to SOHO, which is a project of international cooperation between ESA and NASA. ESA's director of science will also be present, to relate SOHO to ESA's general science programme. A lunch-time talk by the BNSC's director of science completes the line-up of speakers. This is also an exceptional opportunity for the press to meet and interview scientists from all over Europe and the USA, who are attending a meeting at the Rutherford Appleton Laboratory of SOHO's Science Working Team (SWT). Journalists are usually excluded from such meetings. The Rutherford Appleton Laboratory plays a prominent part in SOHO, particularly through its provision of the CDS ultraviolet spectrometer. A visit to the CDS group will provide a chance to see what space research is really like. Please indicate your intention to attend, on the accreditation form that follows the schedule. Guidance on how to get to the Rutherford Appleton Laboratory is appended. PROGRAMME Rutherford Appleton Laboratory (RAL), 28 April 1998 10:30 Assembly of

  17. Reading and Not-Printing: Obstruction at the Crater Press

    Directory of Open Access Journals (Sweden)

    Richard Parker

    2014-11-01

    Full Text Available I will begin this paper with a brief and partial history of American printing, detecting a shared predilection for a noticeably maverick relation to the printed page in the works (printed and otherwise of Samuel Keimer and Benjamin Franklin during the colonial period, and the works of Walt Whitman, Emily Dickinson and Mark Twain in the nineteenth-century. I term the interrupted, dialectical printing that connects all of these writer/printers ‘not-printing’, and offer some explanation of his term and a description of some of its manifestations. I will then move on to consider how the idea of ‘not-printing’ might be helpful for the consideration of some contemporary British and American poets and printers before concluding with a description of some of the ways that the productive constraints of such a practice have influenced my own work as editor and printer at the Crater Press.

  18. Texture in equal-channel angular pressed aluminum and nickel

    Energy Technology Data Exchange (ETDEWEB)

    Vogel, S.C.; Beyerlein, I.J.; Bourke, M.A.M.; Tome, C.N.; Rangaswamy, P. [Los Alamos National Lab., Los Alamos, NM (United States); Xu, C.; Langdon, T.G. [Univ. of Southern California, Los Angeles, CA (United States)

    2002-07-01

    Nano-structured metals with advantageous mechanical properties can be produced using severe plastic deformation techniques such as equal channel angular pressing (ECAP). Metals and alloys processed by ECAP have much higher yield strengths than the equivalent unprocessed material while retaining high ductilities, an extremely attractive combination of properties. Implicit in the process are the introduction of repetitive shear strains of 100% which introduce texture, the modeling of which is challenging. In this work, we present results from a neutron diffraction study on aluminum and nickel samples processed by ECAP. The results are compared to predictions from a visco-plastic self-consistent (VPSC) model. By taking into account grain-grain interactions in the model the agreement between the predicted and measured orientation distributions is improved. The results show also that the initial texture affects the texture evolution, at least up to strains of the order of {proportional_to}1, i.e. one ECAP pass. (orig.)

  19. Hot isostatic pressing of nanosized WC-Co hardmetals

    International Nuclear Information System (INIS)

    Azcona, I.; Ordonez, A.; Sanchez, J.M.; Castro, F.; Dominguez, L.

    2001-01-01

    A new technique based on hot isostatic pressing (HIP) has been developed to produce dense nanosized WC-Co hardmetals without the addition of grain growth inhibitors. The glass encapsulation process is the key for the effective application of isostatic pressure at temperatures well below those usually required for reaching the closed porosity state in the WC-Co system. Fully dense WC-Co samples with cobalt contents ranging from 10 to 12 wt. % have been obtained by this technique at temperatures between 1000 o C and 1200 o C with 150 MPa of applied isostatic pressure for 30 minutes. The role of isostatic pressure on the activation of densification mechanisms is discussed. (author)

  20. Cold-pressed and hot-pressed rapeseed oil: The effects of roasting and seed moisture on the antioxi- dant activity, canolol, and tocopherol level.

    Science.gov (United States)

    Siger, Aleksander; Józefiak, Marta; Górnaś, Paweł

    2017-01-01

    The paper looks at the levels of canolol, tocopherols and antioxidant activity in cold-pressed and hot-pressed rapeseed oils produced from seeds of various moisture levels (5%, 7.5%, and 10%). The paper also considers the effects of seed roasting on the levels of these compounds. The material used for the tests was rapeseed cv. Adrianna. The quality of the oils obtained is determined using peroxide and acid values. The levels of canolol and tocopherols are analyzed using HPLC. The DPPH radical-scavenging activity method for oil samples and phenolic extract from oils was used. It has been demonstrated that the oils produced from rapeseeds with a 5% moisture content, and   in particular from cold-pressed oils, were characterized by the lowest peroxide values. Cold-pressed oils produced from rapeseeds with a 5% moisture content were characterized by higher levels of tocopherols and plastochromanol-8. In the case of hot-pressed oils, the highest levels of tocopherols were found in oils pro- duced from seeds with a 7.5% moisture content, and the greatest amount of PC-8 (more than 4 mg/100 g) was found in oils produced from seeds with a 10% moisture content. Hot-pressed oils have been shown to have higher levels of these compounds than cold-pressed oils. Both roasting and hot pressing led to an increase in the amount of canolol in the oils investigated. When analysing the antioxidant activity of the oils and phenolic extracts it was shown that phenolic compounds are responsible for approx. 10% of total antioxidant activity. Various levels of biologically active compounds were shown to be present in the rapeseed oil obtained from raw materials of a varying moisture content. The type of pressing process (cold-pressing or hot-pressing) and whether the seeds have undergone roasting has also been shown to affect the resulting oil and the level of native antioxidants it contains.

  1. Fatigue effects on bar kinematics during the bench press.

    Science.gov (United States)

    Duffey, Michael J; Challis, John H

    2007-05-01

    The bench press is one of the most popular weight training exercises. Although most training regimens incorporate multiple repetition sets, there are few data describing how the kinematics of a lift change during a set to failure. To examine these changes, recreational lifters (10 men and 8 women) were recruited. The maximum weight each subject could bench press (1RM) was determined. Subjects then performed as many repetitions as possible at 75% of the 1RM load. Three-dimensional kinematic data were recorded and analyzed for all lifts. Statistical analysis revealed that differences between maximal and submaximal lifts and the kinematics of a submaximal lift change as a subject approaches failure in a set. The time to lift the bar more than doubled from the first to the last repetition, causing a decrease in both mean and peak upward velocity. Furthermore, the peak upward velocity occurred much earlier in the lift phase in these later repetitions. The path the bar followed also changed, with subjects keeping the bar more directly over the shoulder during the lift. In general, most of the kinematic variables analyzed became more similar to those of the maximal lift as the subjects progressed through the set, but there was considerable variation between subjects as to which repetition was most like the maximal lift. This study shows that there are definite changes in the lifting kinematics in recreational lifters during a set to failure and suggests it may be particularly important for coaches and less-skilled lifters to focus on developing the proper bar path, rather than reaching momentary muscular failure, in the early part of a training program.

  2. Ductile Fracture Behaviour of Hot Isostatically Pressed Inconel 690 Superalloy

    Science.gov (United States)

    Cooper, A. J.; Brayshaw, W. J.; Sherry, A. H.

    2018-04-01

    Herein we assess the differences in Charpy impact behavior between Hot Isostatically Pressed and forged Inconel 690 alloy over the temperature range of 300 °C to - 196 °C. The impact toughness of forged 690 exhibited a relatively small temperature dependence, with a maximum difference of ca. 40 J measured between 300 °C and - 196 °C, whereas the HIP'd alloy exhibited a difference of approximately double that of the forged alloy over the same temperature range. We have conducted Charpy impact testing, tensile testing, and metallographic analyses on the as-received materials as well as fractography of the failed Charpy specimens in order to understand the mechanisms that cause the observed differences in material fracture properties. The work supports a recent series of studies which assess differences in fundamental fracture behavior between Hot Isostatically Pressed and forged austenitic stainless steel materials of equivalent grades, and the results obtained in this study are compared to those of the previous stainless steel investigations to paint a more general picture of the comparisons between HIP vs forged material fracture behavior. Inconel 690 was selected in this study since previous studies were unable to completely omit the effects of strain-induced martensitic transformation at the tip of the Chary V-notch from the fracture mechanism; Inconel 690 is unable to undergo strain-induced martensitic transformation due to the alloy's high nickel content, thereby providing a sister study with the omission of any martensitic transformation effects on ductile fracture behavior.

  3. Presence of Spotters Improves Bench Press Performance: A Deception Study.

    Science.gov (United States)

    Sheridan, Andrew; Marchant, David C; Williams, Emily L; Jones, Hollie S; Hewitt, Phil A; Sparks, S Andy

    2017-10-24

    Sheridan, A, Marchant, DC, Williams, EL, Jones, HS, Hewitt, PA, and Sparks, SA. Presence of spotters improves bench press performance: a deception study. J Strength Cond Res XX(X): 000-000, 2017-Resistance exercise is a widely used method of physical training in both recreational exercise and athletic populations. The use of training partners and spotters during resistance exercise is widespread, but little is known about the effect of the presence of these individuals on exercise performance. The purpose of the current study was to investigate the effect of spotter presence on bench press performance. Twelve recreationally trained participants (age, 21.3 ± 0.8 years, height, 1.82 ± 0.1 m, and weight, 84.8 ± 11.1 kg) performed 2 trials of 3 sets to failure at 60% of 1 repetition maximum on separate occasions. The 2 trials consisted of spotters being explicitly present or hidden from view (deception). During the trials, total repetitions (reps), total weight lifted, ratings of perceived exertion (RPE), and self-efficacy were measured. Total reps and weight lifted were significantly greater with spotters (difference = 4.5 reps, t = 5.68, p < 0.001 and difference = 209.6 kg, t = 5.65, p < 0.001, respectively). Although RPE and local RPE were significantly elevated in the deception trials (difference = 0.78, f = 6.16, p = 0.030 and difference = 0.81, f = 5.89, p = 0.034, respectively), self-efficacy was significantly reduced (difference = 1.58, f = 26.90, p < 0.001). This study demonstrates that resistance exercise is improved by the presence of spotters, which is facilitated by reduced RPE and increased self-efficacy. This has important implications for athletes and clients, who should perform resistance exercise in the proximity of others, to maximize total work performed.

  4. Flux pinning in hot isostatically pressed Bi2Sr2CaCu2Ox

    International Nuclear Information System (INIS)

    Miller, D.J.; Sengupta, S.; Hettinger, J.D.; Shi, D.; Gray, K.E.; Nash, A.S.; Goretta, K.C.

    1992-01-01

    Magnetic hysteresis data were taken from 4.2 to 35 K on Bi 2 Sr 2 CaCu 2 O x samples that were hot isostatically pressed at 105 MPa in an inert atmosphere at 825 degree C. One set of samples was pressed for only 15 min while the other was pressed for 120 min. The samples pressed for 15 min contained a high density of dislocations and planar faults, while the samples pressed for 120 min contained fewer dislocations and faults, with most dislocations present within subgrain boundaries. The samples with the complex dislocation/planar fault structures exhibited substantially larger hysteresis loops, suggesting enhanced flux pinning

  5. Direct imaging electron microscopy (EM) methods in modern structural biology: overview and comparison with X-ray crystallography and single-particle cryo-EM reconstruction in the studies of large macromolecules.

    Science.gov (United States)

    Miyaguchi, Katsuyuki

    2014-10-01

    Determining the structure of macromolecules is important for understanding their function. The fine structure of large macromolecules is currently studied primarily by X-ray crystallography and single-particle cryo-electron microscopy (EM) reconstruction. Before the development of these techniques, macromolecular structure was often examined by negative-staining, rotary-shadowing and freeze-etching EM, which are categorised here as 'direct imaging EM methods'. In this review, the results are summarised by each of the above techniques and compared with respect to four macromolecules: the ryanodine receptor, cadherin, rhodopsin and the ribosome-translocon complex (RTC). The results of structural analysis of the ryanodine receptor and cadherin are consistent between each technique. The results obtained for rhodopsin vary to some extent within each technique and between the different techniques. Finally, the results for RTC are inconsistent between direct imaging EM and other analytical techniques, especially with respect to the space within RTC, the reasons for which are discussed. Then, the role of direct imaging EM methods in modern structural biology is discussed. Direct imaging methods should support and verify the results obtained by other analytical methods capable of solving three-dimensional molecular architecture, and they should still be used as a primary tool for studying macromolecule structure in vivo. © 2014 Société Française des Microscopies and Société de Biologie Cellulaire de France. Published by John Wiley & Sons Ltd.

  6. Shoulder Muscle Activation of Novice and Resistance Trained Women during Variations of Dumbbell Press Exercises

    Science.gov (United States)

    Luczak, Joshua; Bosak, Andy; Riemann, Bryan L.

    2013-01-01

    Previous research has compared the effects of trunk inclination angle on muscle activation using barbells and Smith machines in men. Whether similar effects occur with the use of dumbbells or in women remains unknown. The purpose was to compare upper extremity surface electromyographical (EMG) activity between dumbbell bench, incline, and shoulder presses. Dominate arm EMG data were recorded for collegiate-aged female resistance trained individuals (n = 12) and novice female resistance trained exercisers (n = 12) from which average EMG amplitude for each repetition phase (concentric, eccentric) was computed. No significant differences were found between experienced and novice resistance trained individuals. For the upper trapezius and anterior deltoid muscles, shoulder press activation was significantly greater than incline press which in turn was significantly greater than bench press across both phases. The bench and incline presses promoted significantly greater pectoralis major sternal activation compared to the shoulder press (both phases). While pectoralis major clavicular activation during the incline press eccentric phase was significantly greater than both the bench and shoulder presses, activation during the bench press concentric phase promoted significantly greater activation than the incline press which in turn was significantly greater than the shoulder press. These results provide evidence for selecting exercises in resistance and rehabilitation programs. PMID:26464884

  7. Shoulder Muscle Activation of Novice and Resistance Trained Women during Variations of Dumbbell Press Exercises

    Directory of Open Access Journals (Sweden)

    Joshua Luczak

    2013-01-01

    Full Text Available Previous research has compared the effects of trunk inclination angle on muscle activation using barbells and Smith machines in men. Whether similar effects occur with the use of dumbbells or in women remains unknown. The purpose was to compare upper extremity surface electromyographical (EMG activity between dumbbell bench, incline, and shoulder presses. Dominate arm EMG data were recorded for collegiate-aged female resistance trained individuals ( and novice female resistance trained exercisers ( from which average EMG amplitude for each repetition phase (concentric, eccentric was computed. No significant differences were found between experienced and novice resistance trained individuals. For the upper trapezius and anterior deltoid muscles, shoulder press activation was significantly greater than incline press which in turn was significantly greater than bench press across both phases. The bench and incline presses promoted significantly greater pectoralis major sternal activation compared to the shoulder press (both phases. While pectoralis major clavicular activation during the incline press eccentric phase was significantly greater than both the bench and shoulder presses, activation during the bench press concentric phase promoted significantly greater activation than the incline press which in turn was significantly greater than the shoulder press. These results provide evidence for selecting exercises in resistance and rehabilitation programs.

  8. The Mediated Amplification of a Crisis: Communicating the A/H1N1 Pandemic in Press Releases and Press Coverage in Europe.

    Science.gov (United States)

    Rossmann, Constanze; Meyer, Lisa; Schulz, Peter J

    2018-02-01

    In the aftermath of the A/H1N1 pandemic, health authorities were criticized for failures in crisis communication efforts, and the media were accused of amplifying the pandemic. Considering these criticisms, A/H1N1 provides a suitable case for examining risk amplification processes that may occur in the transfer of information from press releases to print news media during a health crisis. We integrated the social amplification of risk framework with theories of news decisions (news values, framing) in an attempt to contribute to existing research both theoretically and empirically. We conducted a quantitative content analysis of press releases disseminated by health and governmental authorities, as well as the quality and tabloid press in 10 European countries between March 2009 and March 2011. Altogether 243 press releases, 1,243 quality press articles, and 834 tabloid press articles were coded. Consistent with research on news values and framing the results suggest that quality and tabloid papers alike amplified A/H1N1 risks by emphasizing conflict and damage, presenting information in a more dramatized way, and using risk-amplifying frames to a greater extent and risk-attenuating frames to a lesser extent than press releases. To some extent, the quality and tabloid press differed in how risk information was presented. While tabloid press articles seemed to follow the leading quality press with regards to content and framing of health crisis coverage, they exhibited a stronger emphasis on drama and emotion in the way they presented information. © 2017 Society for Risk Analysis.

  9. Implementing Strategies for Drying and Pressing Wood Without Emissions Controls

    Energy Technology Data Exchange (ETDEWEB)

    Sujit Banerjee; Terrance Conners

    2007-09-07

    Drying and pressing wood for the manufacture of lumber, particleboard, oriented strand board (OSB), veneer and medium density fiberboard (MDF) release volatile organic compounds (VOCs) into the atmosphere. These emissions require control equipment that are capital-intensive and consume significant quantities of natural gas and electricity. The objective of our work was to understand the mechanisms through which volatile organic compounds are generated and released and to develop simple control strategies. Of the several strategies developed, two have been implemented for OSB manufacture over the course of this study. First, it was found that increasing final wood moisture by about 2-4 percentage points reduced the dryer emissions of hazardous air pollutants by over 70%. As wood dries, the escaping water evaporatively cools the wood. This cooling tapers off wood when the wood is nearly dry and the wood temperature rises. Thermal breakdown of the wood tissue occurs and VOCs are released. Raising the final wood moisture by only a few percentage points minimizes the temperature rise and reduces emissions. Evaporative cooling also impacts has implications for VOC release from wood fines. Flaking wood for OSB manufacture inevitable generates fines. Fines dry out rapidly because of their high surface area and evaporative cooling is lost more rapidly than for flakes. As a result, fines emit a disproportionate quantity of VOCs. Fines can be reduced in two ways: through screening of the green furnish and through reducing their generation during flaking. The second approach is preferable because it also increased wood yield. A procedure to do this by matching the sharpness angle of the flaker knife to the ambient temperature was also developed. Other findings of practical interests are as follows: Dielectric heating of wood under low-headspace conditions removes terpenes and other extractives from softwood; The monoterpene content in trees depend upon temperature and seasonal

  10. Effective media communication of disasters: Pressing problems and recommendations

    Directory of Open Access Journals (Sweden)

    Ginter Peter M

    2007-06-01

    Full Text Available Abstract Background Public health officials and journalists play a crucial role in disseminating information regarding natural disasters, terrorism and other human-initiated disasters. However, research suggests that journalists are unprepared to cover terrorism and many types of natural disasters, in part because of lack sufficient expertise in science and medicine and training. The objective of this research was to identify solutions to problems facing journalists and public health public information officer (PIOs of communicating with the public during natural and human-initiated disasters. Methods To assist in identifying the most pressing problems regarding media response to health-related risks such as terrorism and large-scale natural disasters, 26 expert advisors were convened, including leaders representing journalists and public information officers, state health officials, experts in terrorism and emergency preparedness, and experts in health, risk, and science communication. The advisory group participated in pre-arranged interviews and were asked to identify and review bioterrorism educational resources provided to journalist. All advisory group members were then invited to attend a day long meeting January 29, 2004 to review the findings and reach consensus. Results The most pressing problems were found to be a lack of coordination between PIO's and journalists, lack of resources for appropriately evaluating information and disseminating it efficiently, and a difference in perception of PIO's and journalist towards each others role during emergency situations. The advisory board developed a list of 15 recommendations that may enhance communication plans betweens PIO's, journalist and the public. The solutions were meant to be feasible in terms of costs and practical in terms of the professional and organizational realities in which journalists and PIO's work. Conclusion It is clear that PIO's and journalists play crucial roles in

  11. Preparation and Mechanical Properties of Pressed Straw Concrete Brick

    Science.gov (United States)

    Sumarni, S.; Wijanarko, W.

    2018-03-01

    Rice straws have been widely used as wall filler material in China, Australia, and United States, by spinning them into hays with an approximate dimension of 40 cm of height, 40cm of thickness and 60 cm of width, using a machine. Then, the hays are placed into a wall frame until they fill it completely. After that, the wall frame is covered with wire mesh and plastered. In this research, rice straws are to be used as concrete brick fillers, by pressing the straws into hays and then putting them into the concrete brick mold along with mortar. The objective of this research is to investigate the mechanical properties of concrete brick, namely: compressive strength, specific gravity, and water absorption power. This research used experimental research method. It was conducted by using concrete bricks which had 400 cm of width, 200 cm of height, and 100 cm of thickness, made from rice straws, cement, sand, and water as the test sample. The straws were each made different by their volume. The mortars used in this research were made from cement, sand, and water, with the ratio of 1:7:0.5. The concrete bricks were made by pressing straws mixed with glue into hays, and then cut by determined variations of volume. The variations of hays volume were 0 m3, 0.000625 m3, 0.00075 m3, 0.000875 m3, 0.00125 m3, 0.0015 m3, 0.00175 m3, 0.001875 m3, 0.00225 m3, and 0.002625 m3. There were 3 samples for each volumes of hays. The result shows that the straw concrete bricks reached the maximum compressive strength of 1.92 MPa, specific gravity of 1,702 kg/m3, and water absorption level of 3.9 %. Based on the provided measurements of products in the Standar Nasional Indonesia (Indonesian product standardization), the concrete bricks produced attained the prescribed standard quality.

  12. Chromium stress in Brassica juncea L. cv. 'Pusa Jai Kissan' under ...

    African Journals Online (AJOL)

    Chromium (Cr) entering plant tissue inhibits most physiological processes at all levels of metabolism including inhibition of growth, photosynthesis and nitrate assimilation. Since Cr exists in many forms, its toxicity to plants depends on its valence state, with Cr (VI) found to be highly toxic and mobile than Cr (III). Different ...

  13. J'ai le gout du Quebec (I Am in the Mood for Quebec)!

    Science.gov (United States)

    Tetu de Labsade, Francoise

    1981-01-01

    Hails the vitality of the French language in the Quebec region as it manifests itself through advertisements, from political slogans to storefront signs. Discusses the relationship between the language of the Quebecois and their culture, and offers an effective visual commentary through numerous illustrations. (MES)

  14. Chromium stress in Brassica juncea L. cv. 'Pusa Jai Kissan' under ...

    African Journals Online (AJOL)

    Valued Customer

    2012-11-08

    Nov 8, 2012 ... growth, chlorophyll, total soluble protein, free amino acids and nitrate reductase activity. Cr was found .... −2. , 14 h of light,. 10 h of dark and a relative humidity of 60%. .... function of genes that govern the synthesis of enzymes,.

  15. Press forging and optical properties of lithium fluoride

    Science.gov (United States)

    Ready, J. F.; Vora, H.

    1980-07-01

    Lithium fluoride is an important candidate material for windows on high power, short-pulse ultraviolet and visible lasers. Lithium fluoride crystals were press forged in one step over the temperature range 300 to 600 C to obtain fine grained polycrystalline material with improved mechanical properties. The deformation that can be given to a lithium fluoride crystal during forging is limited by the formation of internal cloudiness (veiling) with the deformation limit increasing with increasing forging temperature from about 40 percent at 400 C to 65 percent at 600 C. To suppress veiling, lithium fluoride crystals were forged in two steps over the temperature range 300 to 600 C, to total deformations of 69 to 76 percent, with intermediate annealing at 700 C. This technique yields a material which has lower scattering with more homogeneous microstructure than that obtained in one step forging. The results of characterization of various optical and mechanical properties of single crystal and forged lithium fluoride, including scattering, optical homogeneity, residual absorption, damage thresholds, environmental stability, and thresholds for microyield are described.

  16. Press forging and optical properties of lithium fluoride

    International Nuclear Information System (INIS)

    Ready, J.F.; Vora, H.

    1979-01-01

    Lithium fluoride is an important candidate material for windows on high-power, short-pulse ultraviolet and visible lasers. Lithium fluoride crystals have been press forged in one step over the temperature range 300 to 600 0 c to obtain fine-grained polycrystalline material with improved mechanical properties. The deformation that can be given to a lithium fluoride crystal during forging is limited by the formation of internal cloudiness (veiling) with the deformation limit increasing with increasing forging temperature from about 40% at 400 0 C to 65% at 600 0 C. To suppress veiling, lithium fluoride crystals were forged in two steps over the temperature range 300 to 600 0 C, to total deformations of 69-76%, with intermediate annealing at 700 0 C. This technique yields a material which has lower scattering with more homogeneous microstructure than that obtained in one-step forging. The results of characterization of various optical and mechanical properties of single-crystal and forged lithium fluoride, including scattering, optical homogeneity, residual absorption, damage thresholds, environmental stability, and thresholds for microyield are described

  17. Biogas production from Jatropha curcas press-cake.

    Science.gov (United States)

    Staubmann, R; Foidl, G; Foidl, N; Gübitz, G M; Lafferty, R M; Arbizu, V M; Steiner, W

    1997-01-01

    Seeds of the tropical plant Jatropha curcas (purge nut, physic nut) are used for the production of oil. Several methods for oil extraction have been developed. In all processes, about 50% of the weight of the seeds remain as a press cake containing mainly protein and carbohydrates. Investigations have shown that this residue contains toxic compounds and cannot be used as animal feed without further processing. Preliminary experiments have shown that the residue is a good substrate for biogas production. Biogas formation was studied using a semicontinous upflow anaerobic sludge blanket (UASB) reactor; a contact-process and an anaerobic filter each reactor having a total volume of 110 L. A maximum production rate of 3.5 m3 m"3 d"1 was obtained in the anaerobic filter with a loading rate of 13 kg COD m~3 d"1. However, the UASB reactor and the contact-process were not suitable for using this substrate. When using an anaerobic filter with Jatropha curcas seed cake as a substrate, 76% of the COD was degraded and 1 kg degraded COD yielded 355 L of biogas containing 70% methane.

  18. Biogas production from Jatropha curcas press-cake

    Energy Technology Data Exchange (ETDEWEB)

    Staubmann, R.; Guebitz, G.M.; Lafferty, R.M. [Graz Technical Univ. (Austria)] [and others

    1997-12-31

    Seeds of the tropical plant Jatropha curcas (purge nut, physic nut) are used for the production of oil. Several methods for oil extraction have been developed. In all processes, about 50% of the weight of the seeds remain as a press cake containing mainly protein and carbohydrates. Investigations have shown that this residue contains toxic compounds and cannot be used as animal feed without further processing. Preliminary experiments have shown that the residue is a good substrate for biogas production. Biogas formation was studied using a semicontinous upflow anaerobic sludge blanket (UASB) reactor; a contact-process and an anaerobic filter each reactor having a total volume of 110 L. A maximum production rate of 3.5 m{sup 3} m{sup -3} d{sup -1} was obtained in the anaerobic filter with a loading rate of 13 kg COD m{sup -3} d{sup -1}. However, the UAS reactor and the contact-process were not suitable for using this substrate. When using an anaerobic filter with Jatropha curcas seed cake as a substrate, 76% of the COD was degraded and 1 kg degraded COD yielded 355 L of biogas containing 70% methane. 28 refs., 3 figs., 4 tabs.

  19. The approach of nuclear related issues by the press

    International Nuclear Information System (INIS)

    Manetti, Cristiane Teixeira; Tanimoto, Katia Suemi; Hiromoto, Goro

    2009-01-01

    Nuclear energy has always been a polemic issue, and it is usually more intensely associated, by the general public, to the risks than to the benefits from its use; in this sense, the mass media have clearly had its share of responsibility for public opinion formation. This paper presents a report on the coverage of the nuclear issue in the press, identifying the amount of negative and positive views on the subject, as well as the people involved in the process. The analysis comprises the period from February 2007 to February 2008, right after the edition of the 4th IPCC Report. From that sample, 172 texts published in widely known newspapers and magazines, most of them from Sao Paulo State, were identified. The analyzed speeches were classified according to five information sources: specialists, users, authorities, protagonists and entrepreneurs. It was noted the predominance of positive articles, mainly due to the weight of the favorable speeches by authorities, cited as the most frequent in this paper. (author)

  20. The nuclear controversy as reflected in the daily press

    International Nuclear Information System (INIS)

    Buiren, S. van.

    1980-01-01

    Based on a content analysis of 2047 journal articles of the years 1974 to 1977 on conflicts over nuclear power plants (Wyhl, Brokdorf), the book intends to analyze the role of the media in present social conflicts. The book presents facts and figures concerning the information and opinions on nuclear power in five newspapers and the bias of these newspapers in favour of nuclear power or against it. According to the author, newspaper journalists have failed at least in one thing: to explain the dimensions of the conflict with regard to social policy and to give background information on their own opinions. On the other hand, the press has proved its independence: It is not an extended arm of industrial PR departments - at least not in the nuclear controversy. The greater part of the articles is in opposition to nuclear power. The development and modifications of the arguments stated by the various groups active in the nuclear controversy are analyzed in dependence of the increasingly aggressive nature of the conflict. (HP) [de