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Sample records for maat sapas tepev

  1. Genetics Home Reference: Ohdo syndrome, Maat-Kievit-Brunner type

    Science.gov (United States)

    ... Maat-Kievit-Brunner type Ohdo syndrome, Maat-Kievit-Brunner type Enable Javascript to view the expand/collapse ... Open All Close All Description The Maat-Kievit-Brunner type of Ohdo syndrome is a rare condition ...

  2. Geomorphology and volcanology of Maat Mons, Venus

    Science.gov (United States)

    Mouginis-Mark, Peter J.

    2016-10-01

    Full-resolution (FMIDR) Magellan radar backscatter images have been used to characterize the geology and volcanology of the volcano Maat Mons on Venus. This volcano has often been identified by remote sensing techniques as one of the volcanoes on the planet that could have been recently active, and is the highest volcano on Venus with a relief of ∼9 km. The summit of Maat Mons is characterized by a caldera complex ∼26 × 30 km in diameter with at least six remnant pit craters ∼10 km in diameter preserved in the walls of the caldera, suggesting that multiple small volume (lava flow types, described as "digitate flows", "sheet flows", "fan flows" and "filamentary flows", can be identified on the flanks. Three rift zones can be identified from the distribution of 217 pit craters >1 km in diameter on the flanks. These pits appear to have formed by collapse with no effusive activity associated with their formation. No evidence for explosive volcanism can be identified, despite the (relatively) low atmospheric pressure (∼55 bar) near the summit. There is also a lack of evidence for lava channels, deformation features within the caldera, and thrust faults on the flanks, indicating that the physical volcanology of Maat Mons is simpler than that of typical martian and terrestrial shield volcanoes. Preservation of fine-scale (3-4 pixels) structures within the pit craters and summit pits is consistent with geologically very recent activity, but no evidence for current activity can be identified.

  3. SAPA: A Multi-objective Metric Temporal Planner

    CERN Document Server

    Do, M; 10.1613/jair.1156

    2011-01-01

    SAPA is a domain-independent heuristic forward chaining planner that can handle durative actions, metric resource constraints, and deadline goals. It is designed to be capable of handling the multi-objective nature of metric temporal planning. Our technical contributions include (i) planning-graph based methods for deriving heuristics that are sensitive to both cost and makespan (ii) techniques for adjusting the heuristic estimates to take action interactions and metric resource limitations into account and (iii) a linear time greedy post-processing technique to improve execution flexibility of the solution plans. An implementation of SAPA using many of the techniques presented in this paper was one of the best domain independent planners for domains with metric and temporal constraints in the third International Planning Competition, held at AIPS-02. We describe the technical details of extracting the heuristics and present an empirical evaluation of the current implementation of SAPA.

  4. Afvallen op maat: Een methode met blijvend resultaat {Tweede herziene druk

    NARCIS (Netherlands)

    Strien, T. van

    2014-01-01

    Afvallen. We hebben het Mayodieet, dr. Atkins en sonjabakkeren al geprobeerd. Jojoën we verder naar de volgende hype of kiezen we voor een methode met blijvend resultaat? Wetenschappelijk onderbouwde zelftestmethode In Afvallen op maat – Een methode met blijvend resultaat komt Tatjana van Strien m

  5. Evaluación inmunoenzimática del antígeno recombinante SAPA en perros infectados naturalmente por Trypanosoma cruzi Immunoenzymatic evaluation of the recombinant SAPA protein of Trypanosoma cruzi in naturally infected dogs

    Directory of Open Access Journals (Sweden)

    Rubén O. Cimino

    2012-09-01

    Full Text Available En este trabajo evaluamos el antígeno recombinante SAPA (Shed Acute Phase Antigen para la detección de anticuerpos anti-Trypanosoma cruzi en sueros de perros infectados naturalmente. La técnica utilizada fue el ELISA y los antígenos utilizados fueron un homogenato de parásitos de T. cruzi (ELISA-H y el recombinante SAPA (ELISA-SAPA. Se analizaron 93 sueros de perros por ELISA-H y ELISA-SAPA, los que fueron agrupados de la siguiente manera: grupo 1 (G1, 11 sueros controles negativos de la ciudad de Salta; grupo 2 (G2, 11 sueros controles positivos, pertenecientes a perros infectados naturalmente con T. cruzi; y grupo 3 (G3, 71 sueros de perros pertenecientes a zona endémica de infección chagásica. La sensibilidad y la especificidad del ELISA-SAPA fueron del 100 %. El índice kappa entre ELISA-H y ELISA-SAPA fue de 0,85. Estos resultados confirman que es adecuado el uso del antígeno recombinante SAPA para el diagnóstico de la infección por T. cruzi en perros.We evaluated the recombinant antigen SAPA (Shed Acute Phase Antigen for the detection of Trypanosoma cruzi antibodies in sera from naturally infected dogs. The technique used was ELISA and the antigens were a homogenate of parasite T. cruzi (ELISA-H and the recombinant SAPA (ELISA-SAPA. We analyzed 93 sera from dogs by ELISA-H and ELISA-SAPA, which were grouped as follows: G1: 11 negative control sera from the city of Salta, G2: 11 positive control sera from dogs naturally infected with T. cruzi and G3: 71 samples of dogs belonging to a Chagas disease-endemic area. The sensitivity and specificity of ELISA-SAPA were 100 %. The kappa index between ELISA-H and ELISA-SAPA was 0,85. These results confirm the use of SAPA antigen in the diagnosis of infection with T. cruzi in dogs.

  6. Screening for personality disorder with the Standardised Assessment of Personality: Abbreviated Scale (SAPAS: further evidence of concurrent validity

    Directory of Open Access Journals (Sweden)

    Moran Paul

    2010-01-01

    Full Text Available Abstract Background The assessment of personality disorders (PD is costly and time-consuming. There is a need for a brief screen for personality disorders that can be used in routine clinical settings and epidemiological surveys. Aims: To test the validity of the Standardised Assessment of Personality: Abbreviated Scale (SAPAS as a screen for PD in a clinical sample of substance abusers. Methods Convergent validity of the SAPAS with both categorical and dimensional representations of personality disorders was estimated. Results In this sample, the SAPAS correlated well with dimensional representations of cluster A and C personality disorders, even after controlling for ADHD symptoms, anxiety/depression symptoms and recent substance use. The SAPAS was also significantly associated with total number of PD criteria, although correlation with categorical measures of PD was weak. Conclusions The SAPAS is an valid brief screen for PD as assessed dimensionally.

  7. Haemophilus ducreyi SapA contributes to cathelicidin resistance and virulence in humans.

    Science.gov (United States)

    Mount, Kristy L B; Townsend, Carisa A; Rinker, Sherri D; Gu, Xiaoping; Fortney, Kate R; Zwickl, Beth W; Janowicz, Diane M; Spinola, Stanley M; Katz, Barry P; Bauer, Margaret E

    2010-03-01

    Haemophilus ducreyi is an extracellular pathogen of human epithelial surfaces that resists human antimicrobial peptides (APs). The organism's genome contains homologs of genes sensitive to antimicrobial peptides (sap operon) in nontypeable Haemophilus influenzae. In this study, we characterized the sap-containing loci of H. ducreyi 35000HP and demonstrated that sapA is expressed in broth cultures and H. ducreyi-infected tissue; sapA is also conserved among both class I and class II H. ducreyi strains. We constructed a nonpolar sapA mutant of H. ducreyi 35000HP, designated 35000HPsapA, and compared the percent survival of wild-type 35000HP and 35000HPsapA exposed to several human APs, including alpha-defensins, beta-defensins, and the cathelicidin LL-37. Unlike an H. influenzae sapA mutant, strain 35000HPsapA was not more susceptible to defensins than strain 35000HP was. However, we observed a significant decrease in the survival of strain 35000HPsapA after exposure to LL-37, which was complemented by introducing sapA in trans. Thus, the Sap transporter plays a role in resistance of H. ducreyi to LL-37. We next compared mutant strain 35000HPsapA with strain 35000HP for their ability to cause disease in human volunteers. Although both strains caused papules to form at similar rates, the pustule formation rate at sites inoculated with 35000HPsapA was significantly lower than that of sites inoculated with 35000HP (33.3% versus 66.7%; P = 0.007). Together, these data establish that SapA acts as a virulence factor and as one mechanism for H. ducreyi to resist killing by antimicrobial peptides. To our knowledge, this is the first demonstration that an antimicrobial peptide resistance mechanism contributes to bacterial virulence in humans.

  8. SECURED DATA ON CLOUD ENVIRONMENT BY SAPA PROTOCOL WITH AUTO-RENEWAL

    Directory of Open Access Journals (Sweden)

    K. Prashanthi

    2015-10-01

    Full Text Available Cloud computing is rising as a rife knowledge interactive paradigm to understand users’ knowledge remotely hold on in a web cloud server. Cloud services offer nice conveniences for the users to relish the on-demand cloud applications while not c Knowledge Obstrucity, Forward Security, Universal Composability onsidering the native infrastructure limitations. Throughout the information accessing, completely different users could also be in a very cooperative relationship, and so knowledge sharing becomes vital to attain productive edges. The prevailing security solutions chiefly concentrate on the authentication to understand that a user’s privative knowledge cannot be unauthorized accessed, however neglect a delicate privacy issue throughout a user.It is difficult for the cloud server to request different users for knowledge sharing. The challenged access request itself might reveal the user’s privacy in spite of whether or not it will acquire the information access permissions. During this paper, we have a tendency to propose a shared authority primarily based privacy-preserving authentication protocol (SAPA to deal with higher than privacy issue for cloud storage. Within the SAPA, 1 shared access authority is achieved by anonymous access request matching mechanism with security and privacy concerns (e.g., authentication, knowledge obscurity, user privacy, and forward security; 2 attribute primarily based access management is adopted to understand that the user will solely access its own knowledge fields; 3 proxy re-encryption is applied by the cloud server to supply knowledge sharing among the multiple users. Meanwhile, universal compos ability (UC model is established to prove that the SAPA on paper has the planning correctness. It indicates that the projected protocol realizing privacy-preserving knowledge access authority sharing is enticing for multi-user cooperative cloud applications.

  9. The SapA Protein Is Involved in Resistance to Antimicrobial Peptide PR-39 and Virulence of Actinobacillus pleuropneumoniae.

    Science.gov (United States)

    Xie, Fang; Wang, Yalei; Li, Gang; Liu, Shuanghong; Cui, Ning; Liu, Siguo; Langford, Paul R; Wang, Chunlai

    2017-01-01

    Antimicrobial peptides are essential to the innate immune defense of the mammal against bacterial infection. However, pathogenic bacteria have evolved multiple strategies to resist and evade antimicrobial peptides, which is vital to bacterial survival and colonization in hosts. PR-39 is a linear porcine antimicrobial peptide containing 39 amino acid residues with a high proline content. Resistance to antimicrobial peptide PR-39 has been observed in Actinobacillus pleuropneumoniae. However, little is known about the factors required for this resistance. In the present study, PR-39 exposure increased the expression of the sapA gene in A. pleuropneumoniae. The sapA gene, which encodes a putative peptide transport periplasmic protein, was deleted from this bacterium. The ΔsapA mutant showed increased sensitivity to PR-39 compared to the wild-type MD12 and complemented PΔsapA strains. However, the ΔsapA mutant did not exhibit any alterations in outer membrane integrity. Scanning electron microscopy showed that the ΔsapA mutant displayed morphological defects, as indicated by a deformed and sunken shape after PR-39 treatment. In addition, disruption of the SapA protein led to reduced colonization and attenuated virulence of A. pleuropneumoniae in the BALB/c mouse model. Collectively, these data suggest that SapA acts as one mechanism for A. pleuropneumoniae to counteract PR-39-mediated killing. To the best of our knowledge, this is the first study to show a mechanism underlying antimicrobial peptide resistance in A. pleuropneumoniae.

  10. Evaluating secretion and surface attachment of SapA, an S-layer-associated metalloprotease of Caulobacter crescentus.

    Science.gov (United States)

    Gandham, Lyngrace; Nomellini, John F; Smit, John

    2012-10-01

    Caulobacter crescentus is used to display foreign peptides at high density as insertions into the surface (S)-layer protein (RsaA). Many recombinant RsaA proteins, however, are cleaved by SapA, a 71-kDa metalloprotease, suggesting a role in maintaining S-layer integrity. When overexpressed on a multicopy plasmid SapA was detected on the surface by fluorescent antibody only if RsaA and the O-side chain of LPS that mediates S-layer attachment were removed by mutation, indicating an outer membrane location beneath the S-layer. Secretion was mediated by the RsaA type 1 transporter since secretion was eliminated in transporter deficient strains or by C-terminal deletions in SapA (the presumed location of type 1 secretion signals). Secretion was required to become an active protease; mass spectrometry suggested this might be due to N-terminal processing during secretion, a feature shared with other type 1-secreted proteases. Overexpression leads to additional processing C-terminal to the protease domain, producing a 45-kDa protein. This was demonstrated to be self-processing. Deletion analysis revealed the C-terminal 100 amino acids were sufficient for anchoring and secretion. When protein G was fused to the last 238 amino acids of SapA it was secreted, surface attached and bound immunoglobulin, indicating potential for foreign protein display.

  11. Identification of antigenic epitopes of the SapA protein of Campylobacter fetus using a phage display peptide library.

    Science.gov (United States)

    Zhao, Hailing; Yu, Shenye; Liu, Huifang; Si, Wei; Wang, Chunlai; Liu, Siguo

    2012-12-01

    In this study, we immunized mice with prokaryotically expressed recombinant surface layer protein, SapA, of Campylobacter fetus, generated hybridomas secreting mouse monoclonal antibodies (mAb) targeting SapA, and purified the mAb A2D5 from mouse ascites using saturated ammonium sulfate solution. The mAb A2D5, coated onto ELISA plates, was used to screen the phage random 12-peptide library through three rounds of panning. Following panning, 15 phage clones were randomly chosen and tested for reactivity with mAb A2D5 by indirect ELISA. Single-stranded DNA from positive clones was sequenced and compared with the sequence of SapA to predict the key epitope. ELISA and/or Western blot analyses further validated that synthetic peptides and recombinant peptide mimotopes all interact with mAb A2D5. Nine of ten positive phage clones identified by screening were sequenced successfully. Seven clones shared the same sequence HYDRHNYHWWHT; one had the sequence LSKNLPLTALGN; and the final one had the sequence SGMKEPELRSYS. These three sequences shared high homology with SapA J05577 in the region GNEKDFVTKIYSIALGNTSDVDGINYW, in which the underlined amino acids may serve as key residues in the epitope. ELISA and/or Western blot analyses showed that mAb A2D5 not only interacted with the four synthetic peptide mimotopes, but also with 14 prokaryotically expressed recombinant peptide mimotopes. The mimotopes identified in this study will aid future studies into the pathological processes and immune mechanisms of the SapA protein of C. fetus. Copyright © 2012 Elsevier Ltd. All rights reserved.

  12. The SapA Protein Is Involved in Resistance to Antimicrobial Peptide PR-39 and Virulence of Actinobacillus pleuropneumoniae

    Directory of Open Access Journals (Sweden)

    Fang Xie

    2017-05-01

    Full Text Available Antimicrobial peptides are essential to the innate immune defense of the mammal against bacterial infection. However, pathogenic bacteria have evolved multiple strategies to resist and evade antimicrobial peptides, which is vital to bacterial survival and colonization in hosts. PR-39 is a linear porcine antimicrobial peptide containing 39 amino acid residues with a high proline content. Resistance to antimicrobial peptide PR-39 has been observed in Actinobacillus pleuropneumoniae. However, little is known about the factors required for this resistance. In the present study, PR-39 exposure increased the expression of the sapA gene in A. pleuropneumoniae. The sapA gene, which encodes a putative peptide transport periplasmic protein, was deleted from this bacterium. The ΔsapA mutant showed increased sensitivity to PR-39 compared to the wild-type MD12 and complemented PΔsapA strains. However, the ΔsapA mutant did not exhibit any alterations in outer membrane integrity. Scanning electron microscopy showed that the ΔsapA mutant displayed morphological defects, as indicated by a deformed and sunken shape after PR-39 treatment. In addition, disruption of the SapA protein led to reduced colonization and attenuated virulence of A. pleuropneumoniae in the BALB/c mouse model. Collectively, these data suggest that SapA acts as one mechanism for A. pleuropneumoniae to counteract PR-39-mediated killing. To the best of our knowledge, this is the first study to show a mechanism underlying antimicrobial peptide resistance in A. pleuropneumoniae.

  13. Diagnosis of congenital Trypanosoma cruzi infection: A serologic test using Shed Acute Phase Antigen (SAPA) in mother-child binomial samples.

    Science.gov (United States)

    Volta, Bibiana J; Russomando, Graciela; Bustos, Patricia L; Scollo, Karenina; De Rissio, Ana M; Sánchez, Zunilda; Cardoni, Rita L; Bua, Jacqueline

    2015-07-01

    Chagas congenital infection is an important health problem in endemic and non-endemic areas in which Trypanosoma cruzi-infected women can transmit the parasite to their offspring. In this study, we evaluated the antibody levels against the T. cruzi Shed Acute Phase Antigen (SAPA) in 91 binomial samples of seropositive pregnant women and their infected and non-infected children by ELISA. In 70 children without congenital T. cruzi transmission, the titers of anti-SAPA antibodies were lower than those of their seropositive mothers. In contrast, 90.5% of 21 congenitally infected children, at around 1 month of age, showed higher anti-SAPA antibody levels than their mothers. Subtracting the SAPA-ELISA mother OD value to the SAPA-ELISA child OD allowed efficient detection of most T. cruzi congenitally infected children immediately after birth, when total anti-parasite antibodies transferred during pregnancy are still present in all children born to seropositive women. A positive correlation was observed between parasitemia levels in mothers and infants evaluated by quantitative DNA amplification and anti-SAPA antibody titers by ELISA. As SAPA serology has proved to be very efficient to detect T. cruzi infection in mother-child binomial samples, it could be of extreme help for early diagnosis of newborns, in maternities and hospitals where DNA amplification is not available. This prompt diagnosis may prevent drop out of the long-term follow-up for future diagnosis and may ensure early trypanocidal treatment, which has proved to be efficient to cure infants with congenital Chagas disease.

  14. Reactividad del antígeno GST-SAPA de Trypanosoma cruzi frente a sueros de pacientes con enfermedad de Chagas y leishmaniasis

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    José Gil

    2011-04-01

    Full Text Available El diagnóstico serológico de la infección producida por Trypanosoma cruzi es de especial relevancia dado que los métodos parasitológicos tienen, en las fases indeterminada y crónica, una sensibilidad limitada. El antígeno SAPA fue usado en diversos estudios y demostró ser un buen candidato para el diagnóstico de la infección por T. cruzi. La enfermedad de Chagas y la leishmaniasis son endémicas en el norte de Salta, con posibles zonas de solapamiento. Este hecho suele dar lugar a infecciones mixtas T. cruzi-Leishmania spp., con la consecuente probabilidad de diagnóstico cruzado cuando se usan antígenos no específicos. Se evaluó la reactividad del antígeno GST-SAPA en la prueba de ELISA (ELISA-SAPA frente a sueros de personas infectadas por T. cruzi (n = 154, con leishmaniasis (n = 66, infecciones mixtas (n = 29 y controles negativos (n = 28, usando como pruebas de referencia para el diagnóstico de la infección por T. cruzi kits comerciales de ELISA y HAI. Se calculó la sensibilidad, especificidad e índice de concordancia kappa de la prueba de ELISA-SAPA, para la detección de infección por T. cruzi. Entre los sueros de pacientes con leishmaniasis estudiados se detectó un 30.5% de infecciones mixtas. Para la detección de infección por T. cruzi, ELISA-SAPA mostró una sensibilidad del 97.1% (intervalo de confianza del 95%: 94.5-99.9, una especificidad del 100% (intervalo de confianza del 95%: 99.5-100 y un índice de concordancia kappa de 96 (intervalo de confianza del 95%:93-99%, comparado con las pruebas serológicas comerciales. Los valores de sensibilidad, especificidad y concordancia calculados muestran una alta eficiencia de ELISA-SAPA.

  15. Wintertarwe op maat bemesten

    NARCIS (Netherlands)

    Timmer, R.D.

    2001-01-01

    In proeven op vier locaties met verschillende tarwerassen onderzocht PPO de werking van de chlorophylmeter, waarmee de groenheid van een tarwegewas wordt vastgesteld en vervolgens daarmee de stikstofbemesting wordt afgestemd op de behoefte. Met het systeem blijkt het goed mogelijk de optimale tweede

  16. Salmonellabeheersing op maat

    NARCIS (Netherlands)

    Gaag, van der M.; Mul, M.F.

    2003-01-01

    Om vleesvarkenshouders te helpen om Salmonella op het bedrijf te beheersen zijn acht checklisten ontwikkeld. Hiermee kunnen de bedrijfsspecifieke beheersmaatregelen op gestructureerde wijze bepaald worden

  17. Sapa And Base Communication Of Sambas Society A Case Of Malay-Madurese Post-Conflict 1999-2014

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    Wahab

    2015-02-01

    Full Text Available Abstract This article discusses the impact of inter-ethnic conflict in 1999 to the multi-ethnic community life in Sambas and offers a concept of education as a modified formulation of the local wisdom in the communication aspect that the Malay ethnic community in Sambas have in responding relations between ethnic groups post-conflict of ethnics in 1999. The methodology used is literature review observation interview and documentation-based qualitative analysis. The result is that ethnic conflict 1999 in Sambas West Kalimantan causes a number of problems or moral and social impacts in some small communities of Malay. By gaining the value of local wisdom into a new form of education an effort to respond the post-conflict negative impact through cultural communication greeting of sapa and base that shows a polite language education in Malay Sambas society and even the culture is believed to be an alternative solution that can deal with inter-ethnic conflicts and prevent conflict to happen again

  18. Terrestrial soil pH and MAAT records based on the MBT/CBT in the southern South China Sea: implications for the atmospheric CO2 evolution in Southeast Asia

    Science.gov (United States)

    Dong, L.; Li, L.; Li, Q.; Zhang, C.

    2013-12-01

    Liang Dong1, Li Li1, Qianyu Li1,2, Chuanlun L. Zhang1,3 1State Key Laboratory of Marine Geology, Tongji University, Shanghai 200092, China 2School of Earth and Environment Sciences, University of Adelaide, SA 5005, Australia 3Department of Marine Sciences, University of Georgia, Athens, GA 30602, USA The methylation index of branched tetraethers (MBT) and/or the cyclization ratio of branched tetraethers (CBT) are derived from the branched glycerol dialkyl Glycerol tetraethers (GDGTs) of bacterial origin and are widely used to reconstruct the terrestrial soil pH and mean annual air temperature (MAAT); however, these proxies are less frequently used in the oceanic settings. Here we provide the first high resolution records of soil pH and MAAT since the last glacial maximum based on the sedimentary core of MD05-2896 in the southern South China Sea. The MAAT record exhibited typical glacial and interglacial cycles and was consistent with the winter insolation variation. The pH values were lower (6.4-7) in the glacial time and higher (7-8.4) in the interglacial time. Changes in soil pH allowed the evaluation of changes in soil CO2 based on the atmosphere-soil CO2 balance. The results imply that the lower winter MAAT variation with a lower winter atmospheric CO2 concentration might have resulted in a higher pH in the interglacial period. Our records provide a new insight into the evolution of atmospheric CO2 between glacial and interglacial cycles in East Asia. Key words: South China Sea, MBT/CBT, b-GDGTs, MAAT, pH

  19. Volcano morphometry and volume scaling on Venus

    Science.gov (United States)

    Garvin, J. B.; Williams, R. S., Jr.

    1994-03-01

    A broad variety of volcanic edifices have been observed on Venus. They ranged in size from the limits of resolution of the Magellan SAR (i.e., hundreds of meters) to landforms over 500 km in basal diameter. One of the key questions pertaining to volcanism on Venus concerns the volume eruption rate or VER, which is linked to crustal productivity over time. While less than 3 percent of the surface area of Venus is manifested as discrete edifices larger than 50 km in diameter, a substantial component of the total crustal volume of the planet over the past 0.5 Ga is related to isolated volcanoes, which are certainly more easily studied than the relatively diffusely defined plains volcanic flow units. Thus, we have focused our efforts on constraining the volume productivity of major volcanic edifices larger than 100 km in basal diameter. Our approach takes advantage of the topographic data returned by Magellan, as well as our database of morphometric statistics for the 20 best known lava shields of Iceland, plus Mauna Loa of Hawaii. As part of this investigation, we have quantified the detailed morphometry of nearly 50 intermediate to large scale edifices, with particular attention to their shape systematics. We found that a set of venusian edifices which include Maat, Sapas, Tepev, Sif, Gula, a feature at 46 deg S, 215 deg E, as well as the shield-like structure at 10 deg N, 275 deg E are broadly representative of the approx. 400 volcanic landforms larger than 50 km. The cross-sectional shapes of these 7 representative edifices range from flattened cones (i.e., Sif) similar to classic terrestrial lava shields such as Mauna Loa and Skjaldbreidur, to rather dome-like structures which include Maat and Sapas. The majority of these larger volcanoes surveyed as part of our study displayed cross-sectional topographies with paraboloidal shaped, in sharp contrast with the cone-like appearance of most simple terrestrial lava shields. In order to more fully explore the

  20. Screening for personality disorder in incarcerated adolescent boys: preliminary validation of an adolescent version of the standardised assessment of personality – abbreviated scale (SAPAS-AV

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    Kongerslev Mickey

    2012-07-01

    Full Text Available Abstract Background Personality disorder (PD is associated with significant functional impairment and an elevated risk of violent and suicidal behaviour. The prevalence of PD in populations of young offenders is likely to be high. However, because the assessment of PD is time-consuming, it is not routinely assessed in this population. A brief screen for the identification of young people who might warrant further detailed assessment of PD could be particularly valuable for clinicians and researchers working in juvenile justice settings. Method We adapted a rapid screen for the identification of PD in adults (Standardised Assessment of Personality – Abbreviated Scale; SAPAS for use with adolescents and then carried out a study of the reliability and validity of the adapted instrument in a sample of 80 adolescent boys in secure institutions. Participants were administered the screen and shortly after an established diagnostic interview for DSM-IV PDs. Nine days later the screen was readministered. Results A score of 3 or more on the screening interview correctly identified the presence of DSM-IV PD in 86% of participants, yielding a sensitivity and specificity of 0.87 and 0.86 respectively. Internal consistency was modest but comparable to the original instrument. 9-days test-retest reliability for the total score was excellent. Convergent validity correlations with the total number of PD criteria were large. Conclusion This study provides preliminary evidence of the validity, reliability, and usefulness of the screen in secure institutions for adolescent male offenders. It can be used in juvenile offender institutions with limited resources, as a brief, acceptable, staff-administered routine screen to identify individuals in need of further assessment of PD or by researchers conducting epidemiological surveys.

  1. Hydrographic and Impairment Statistics Database: SAPA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  2. Viimsis kingiti kallis maatükk / Anneli Ammas

    Index Scriptorium Estoniae

    Ammas, Anneli, 1962-

    2005-01-01

    Sihtasutus Rohuneeme Puhkekeskus, Viimsi Golf ning Rohuneeme jooksu- ja suusaklubi esindajad vormistasid 23. novembril lepingu, mille kohaselt läks 120 ha mereäärse metsamaa hoonestusõigus kahele spordiklubile. Maa kasutamise eest tuleb neil SA-le maksta vaid 2% maa maksustamishinnast aastas ehk alla 4000 krooni. Viimsi vald kui sihtasutuse asutaja leiab, et sihtasutus ei täida enam oma eesmärke, uue vallavanema Urmas Arumäe nimetatud sihtasutuse uus nõukogu läks kohe sihtasutusena laiali. Vt. samas intervjuud Jaan Alveriga

  3. De maat genomen. De Nederlandse economie in de negentiende eeuw

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    R.T. Griffiths

    2002-01-01

    Full Text Available Taking Stock. The Dutch economy in the Nineteenth CenturyThe publication entitled Nederland, 1780-1914. Staat, Instituties en Economische Ontwikkeling [The Netherlands, 1780-1914. The State, Institutions and Economic Development] is the culmination of a large-scale project called the Reconstruction of the Dutch National Accounts. The analyses are based on new data generated by the project. The results confirm firstly the occurrence of economic growth during the first half of the 19th century and, secondly, that the process of modern economic growth originated around 1860. Furthermore, the book stands out for its analysis of the interaction between politics and the economy. However, there are mistakes and inconsistencies in the way the statistics, on which the analyses are based, are presented. Also, the absence of any international comparisons in the book represents a missed opportunity.

  4. Eenvoudige diagnostiek leidt tot behandeling op maat van patellofemorale instabiliteit

    NARCIS (Netherlands)

    Kampen, A. van; Koeter, S.

    2006-01-01

    Three patients presented with patellar instability. On physical examination, the first patient, a 20-year-old male soccer player, reported pain at the medial insertion ofthe medial patellofemoral ligament (MPFL) after a traumatic patella luxation. He was successfully treated by MPFL reconstruction.

  5. Eenvoudige diagnostiek leidt tot behandeling op maat van patellofemorale instabiliteit

    NARCIS (Netherlands)

    Kampen, A. van; Koeter, S.

    2006-01-01

    Three patients presented with patellar instability. On physical examination, the first patient, a 20-year-old male soccer player, reported pain at the medial insertion ofthe medial patellofemoral ligament (MPFL) after a traumatic patella luxation. He was successfully treated by MPFL reconstruction.

  6. De maat genomen. De Nederlandse economie in de negentiende eeuw

    Directory of Open Access Journals (Sweden)

    R.T. Griffiths

    2002-01-01

    Full Text Available Taking Stock. The Dutch economy in the Nineteenth CenturyThe publication entitled Nederland, 1780-1914. Staat, Instituties en Economische Ontwikkeling [The Netherlands, 1780-1914. The State, Institutions and Economic Development] is the culmination of a large-scale project called the Reconstruction of the Dutch National Accounts. The analyses are based on new data generated by the project. The results confirm firstly the occurrence of economic growth during the first half of the 19th century and, secondly, that the process of modern economic growth originated around 1860. Furthermore, the book stands out for its analysis of the interaction between politics and the economy. However, there are mistakes and inconsistencies in the way the statistics, on which the analyses are based, are presented. Also, the absence of any international comparisons in the book represents a missed opportunity.

  7. Eksminister Heiki Kranich noolib maatükki Nõmmel / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2007-01-01

    Maadevahetustaotluste hulk on suurenenud kaks korda. Endise keskkonnaministri Heiki Kranichi firma South Kinnisvara ja selle juhi maavahetustaotlusest, Valeri Kirsi algatatud maavahetusest. Kaart: Kranichi firma ja Loosi maadevahetuse soov. Lisa: Maadevahetuse reeglid muutuvad

  8. EFEK PELAYANAN SENYUM, SALAM, SAPA PETUGAS KASIR TERHADAP KEPUASAN KONSUMEN SUPERMARKET

    Directory of Open Access Journals (Sweden)

    Muhammad Riza Febrianto

    2013-04-01

    Full Text Available This research was experimental research aimed at knowing the effect of smiling, greeting, and addressing of cashier toward the satisfaction of supermarket’s customers. This research used posttest only control group design. The subject were 62 customers of supermarket X.4. They were randomly divided into two groups, experiment group and control group. The Mann-Whitney U Test was used to analyze the costumer statisfaction. The result show there is significant difference between experimental group and control group after receive service with smiling, greeting and addressing from cashier. The research result show that smiling, greeting and addressing of cashier influences the satisfaction of supermarket’s customers effectively.

  9. A SAPA Project Update: On the Structure of phrased Self-Report Personality Items

    Directory of Open Access Journals (Sweden)

    David M. Condon

    2017-06-01

    Full Text Available Two large samples were collected to evaluate the structure of traits in the temperament domain. In both samples, participants were administered random subsets of public-domain personality items from a larger pool of approximately 700 items. These data broadly cover the most widely used, public-domain measures of personality (though this breadth is not likely free of theoretical bias. When combined with a third, previously-shared dataset that used the same methodological design [4], the sample includes more than 125,000 participants from more than 220 countries and regions. Re-use potential includes many types of structural, correlational, and network analyses of personality and a wide range of demographic and psychographic constructs. The data are available in both rdata and csv formats.

  10. Clinical utility of Standardised Assessment of Personality - Abbreviated Scale (SAPAS) among patients with first episode depression

    DEFF Research Database (Denmark)

    Bukh, Jens Drachmann; Bock, Camilla; Vinberg, Maj;

    2010-01-01

    , by the Structured Clinical Interview for DSM-IV Personality Disorders. RESULTS: We found, that a cut-off of 3 on the screen correctly identified the presence of comorbid personality disorder in 73.1% of the patients. The sensitivity and specificity were 0.80 and 0.70, respectively. LIMITATIONS: The findings cannot...

  11. Selected personality data from the SAPA-Project: On the structure of phrased self-report items

    Directory of Open Access Journals (Sweden)

    David M Condon

    2015-08-01

    Full Text Available These data were collected to evaluate the structure of personality constructs in the temperament domain. In the context of modern personality theory, these constructs are typically construed in terms of the Big Five (Conscientiousness, Agreeableness, Neuroticism, Openness, and Extraversion though several additional constructs were included here. Approximately 24,000 individuals were administered random subsets of 696 items from 92 public-domain personality scales using the Synthetic Aperture Personality Assessment method between December 8, 2013 and July 26, 2014. The data are available in rdata format and are accompanied by documentation stored as a text file. Re-use potential include many types of structural and correlational analyses of personality.

  12. Selected personality data from the SAPA-Project: On the structure of phrased self-report items

    Directory of Open Access Journals (Sweden)

    David M Condon

    2015-08-01

    Full Text Available These data were collected to evaluate the structure of personality constructs in the temperament domain. In the context of modern personality theory, these constructs are typically construed in terms of the Big Five (Conscientiousness, Agreeableness, Neuroticism, Openness, and Extraversion though several additional constructs were included here. Approximately 24,000 individuals were administered random subsets of 696 items from 92 public-domain personality scales using the Synthetic Aperture Personality Assessment method between December 8, 2013 and July 26, 2014. The data are available in rdata format and are accompanied by documentation stored as a text file. Re-use potential include many types of structural and correlational analyses of personality. 

  13. De preventiemedewerker op maat van gemeenten : handreiking voor invoering van preventietaken voor de alledaagse zorg voor veiligheid en gezondheid naar aanleiding van de wijziging Arbowet juli 2005

    NARCIS (Netherlands)

    Kwantes, J.H.

    2005-01-01

    De werkgever en de OR spelen een sleutelrol bij het vaststellen van de preventietaken. Deze handreiking is daarom geen blauwdruk, maar wijst op de overwegingen en aandachtspunten die van belang zijn om een juiste keuze te maken. Een keuze die aansluit bij de bestaande risico's en het bestaande arbob

  14. Job crafting: De psychologie van een baan op maat. Inleiding op het themanummer (Job crafting: The psychology of customizing jobs. Introduction to the special issue)

    NARCIS (Netherlands)

    Dorenbosch, L.; Bakker, A.B.; Demerouti, E.; Dam, K. van

    2013-01-01

    This special issue pays attention to a relatively new research topic in work and organizational psychology: job crafting. Job crafting refers to the modifications employees apply to their jobs in order to better fit this job to their needs and abilities. In this introductory article, we first explai

  15. Screening for personality disorder in a sample of incarcerated male youth: preliminary validation of the Standardised Assessment of Personality-Abbreviated Scale (SAPAS)

    DEFF Research Database (Denmark)

    Kongerslev, Mickey; Bo, Sune; Simonsen, Erik

    2011-01-01

    prisons and secure institutions Within one week a clinical psychologist administered the Structured Clinical Inter-view for DSM-IV Personality Disorders (SCID-II) and the Psychopathy Checklist: Youth Version (PCL:YV) to assess for personality disorders and psychopathy In order to control for confounding...

  16. Turning over a New Leaf : precision medicine in oncology guided by circulating tumor cell counts and characteristics : Een Nieuw Hoofdstuk : therapie op maat aan de hand van circulerende tumorcel aantallen en karakteristieken

    NARCIS (Netherlands)

    W. Onstenk (Wendy)

    2016-01-01

    markdownabstractMany new treatments have been put on the market over the past decades, but have been proven to be effective in only 20-50% of the patients. To improve the prognosis of patients with cancer and in order to keep cancer care affordable, it will be important to select effective treatment

  17. Newtonian Mechanics for Elementary School Teachers.

    Science.gov (United States)

    Cleland, Winston E.

    This monograph presents a module that introduces Newtonian Mechanics and related Science - A Process Approach (SAPA) materials. The activities are designed to give the necessary background for understanding the physics involved with the SAPA exercises relevant to this topic. The module is designed so that it can be used with individualized format.…

  18. Dicty_cDB: Contig-U04637-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 08 |pid:none) Naegleria fowleri naegleriapore A ... 60 1e-07 U66367_1( U66367 |pid:none) Dictyostelium disco...ideum SapA (sapA) m... 60 1e-07 AF196309_1( AF196309 |pid:none) Naegleria fowleri naegleria

  19. Dicty_cDB: VFO870 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 367 |pid:none) Dictyostelium discoideum SapA (sapA) m... 93 5e-18 AF108656_1( AF108656 |pid:none) Gallus gallus prosa...-17 BC056717_1( BC056717 |pid:none) Danio rerio prosaposin, mRNA (cDNA... 89 7e-17 AF276996_1( AF276996 |pid

  20. Dicty_cDB: VFG549 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ctyostelium discoideum SapA (sapA) m... 281 4e-75 AK223290_1( AK223290 |pid:none) Homo sapiens mRNA for prosa...e-08 AB209776_1( AB209776 |pid:none) Homo sapiens mRNA for prosaposin v... 57 2e-07 CR861454_1( CR861454 |pi

  1. Salicylic Acid-Based Polymers for Guided Bone Regeneration Using Bone Morphogenetic Protein-2.

    Science.gov (United States)

    Subramanian, Sangeeta; Mitchell, Ashley; Yu, Weiling; Snyder, Sabrina; Uhrich, Kathryn; O'Connor, J Patrick

    2015-07-01

    Bone morphogenetic protein-2 (BMP-2) is used clinically to promote spinal fusion, treat complex tibia fractures, and to promote bone formation in craniomaxillofacial surgery. Excessive bone formation at sites where BMP-2 has been applied is an established complication and one that could be corrected by guided tissue regeneration methods. In this study, anti-inflammatory polymers containing salicylic acid [salicylic acid-based poly(anhydride-ester), SAPAE] were electrospun with polycaprolactone (PCL) to create thin flexible matrices for use as guided bone regeneration membranes. SAPAE polymers hydrolyze to release salicylic acid, which is a nonsteroidal anti-inflammatory drug. PCL was used to enhance the mechanical integrity of the matrices. Two different SAPAE-containing membranes were produced and compared: fast-degrading (FD-SAPAE) and slow-degrading (SD-SAPAE) membranes that release salicylic acid at a faster and slower rate, respectively. Rat femur defects were treated with BMP-2 and wrapped with FD-SAPAE, SD-SAPAE, or PCL membrane or were left unwrapped. The effects of different membranes on bone formation within and outside of the femur defects were measured by histomorphometry and microcomputed tomography. Bone formation within the defect was not affected by membrane wrapping at BMP-2 doses of 12 μg or more. In contrast, the FD-SAPAE membrane significantly reduced bone formation outside the defect compared with all other treatments. The rapid release of salicylic acid from the FD-SAPAE membrane suggests that localized salicylic acid treatment during the first few days of BMP-2 treatment can limit ectopic bone formation. The data support development of SAPAE polymer membranes for guided bone regeneration applications as well as barriers to excessive bone formation.

  2. Agricultural labourers and their wages in Estland in 1885-1913 / Kersti Lust

    Index Scriptorium Estoniae

    Lust, Kersti, 1976-

    2007-01-01

    Eesti maatööliste palgast ja selles "moderniseerumise" ajal toimunud muutustest Põhja-Eesti mõisatööliste näitel. Nihkeid maatööliste ostujõus on püütud hinnata rukki ja või hindade alusel konstrueeritud indeksi abil

  3. Economische consequenties van een zuivelpool voor biologische melk

    NARCIS (Netherlands)

    Hoste, R.; Horne, van P.L.M.

    2007-01-01

    EkoHolland-op-Maat en Natuurweide hebben behoefte aan inzicht in economische consequenties van een zuivelpoolconcept. Voordelen van flexibel inspelen op vraag- en aanbodfluctuaties (melk-op-maat) zijn beperkt en hoeven niet per se door een onafhankelijke derde partij ingevuld te worden. Transportbes

  4. Resilience and vulnerability of permafrost to climate change

    Science.gov (United States)

    M.Torre Jorgenson; Vladimir Romanovsky; Jennifer Harden; Yuri Shur; Jonathan O' Donnell; Edward A.G. Schuur; Mikhail Kanevskiy; Sergei. Marchenko

    2010-01-01

    The resilience and vulnerability of permafrost to climate change depends on complex interactions among topography, water, soil, vegetation, and snow, which allow permafrost to persist at mean annual air temperatures (MAATs) as high as +2 °C and degrade at MAATs as low as -20°C. To assess these interactions, we compiled existing data and tested effects of varying...

  5. Sources and distributions of branched and isoprenoid tetraether lipids on the Amazon shelf and fan: Implications for the use of GDGT-based proxies in marine sediments

    NARCIS (Netherlands)

    Zell, C.; Kim, J.H.; Hollander, D.; Lorenzoni, L.; Baker, P.; Guizan Silva, G.S.; Sinninghe Damsté, J.S.

    2014-01-01

    Branched glycerol dialkyl glycerol tetraethers (brGDGTs) in river fan sediments have been used successfully to reconstruct mean annual air temperature (MAAT) and soil pH of the Congo River drainage basin. However, in a previous study of Amazon deep-sea fan sediments the reconstructed MAATs were ca.

  6. Agricultural labourers and their wages in Estland in 1885-1913 / Kersti Lust

    Index Scriptorium Estoniae

    Lust, Kersti, 1976-

    2007-01-01

    Eesti maatööliste palgast ja selles "moderniseerumise" ajal toimunud muutustest Põhja-Eesti mõisatööliste näitel. Nihkeid maatööliste ostujõus on püütud hinnata rukki ja või hindade alusel konstrueeritud indeksi abil

  7. Download this PDF file

    African Journals Online (AJOL)

    Figure 3: Security services offered in South Africa as at 2005 .... services and technology available to a contract security ... social, moral, and personal dynamics into the arena of ..... nabbed over Cape Town hotel robbery, SAPA, 12 July. 2011 ...

  8. Dicty_cDB: [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ing significant alignments: (bits) Value N U66367 |U66367.1 Dictyostelium discoideum SapA (sapA) mRNA, parti...al cds. 420 e-114 1 AC116957 |AC116957.2 Dictyostelium discoideum chromosome 2 ma...p 1685067-2090751 strain AX4, complete sequence. 38 0.003 4 AF361947 |AF361947.1 Dictyostelium discoideum Sg...alignments: (bits) Value U66367_1( U66367 |pid:none) Dictyostelium discoideum SapA (sapA) m... 122 4e-27 AC0...VF (Link to library) VFB590 (Link to dictyBase) - - - Contig-U09552-1 VFB590P (Link

  9. Dicty_cDB: [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Value N U66367 |U66367.1 Dictyostelium discoideum SapA (sapA) mRNA, partial cds. 1195 0.0 1 AC115599 |AC115599.2 Dictyostelium di... 60 4e-05 1 AC115684 |AC115684.2 Dictyostelium discoideum chromosome 2 map 3108975-3191114 strain AX4, compl...ete sequence. 60 4e-05 1 AC114261 |AC114261.2 Dictyostelium discoideum chromosome... 2 map 126059-159710 strain AX4, complete sequence. 60 4e-05 1 AC116551 |AC116551.2 Dictyostelium discoideum...lue U66367_1( U66367 |pid:none) Dictyostelium discoideum SapA (sapA) m... 385 e-105 AF196308_1( AF196308 |pi

  10. The role of materiality in apprenticeships: the case of the Suame Magazine, Kumasi, Ghana

    NARCIS (Netherlands)

    Jaarsma, Thomas; Maat, Harro; Wals, Arjen; Richards, Paul

    2011-01-01

    Jaarsma, T., Maat, H., Richards, P., & Wals, A. (2011). The role of materiality in apprenticeships: The case of the suame magazine, kumasi, ghana. Journal of Vocational Education & Training, 63(3), 439-449.

  11. Vuil, vuiler, schoonst. Schrikken van rapporten over uitstoot stikstofoxiden in praktijk

    NARCIS (Netherlands)

    2015-01-01

    Dieselmotoren van personen- en bestelauto’s blijken in de praktijk veel vuiler dan de norm voor stikstofoxiden. Euro 6-vrachtauto’s doen het echter juist heel goed. Maat overziet al iemand de gevolgen voor en door het overheidsbeleid?

  12. Plaadid / Tiiu Laks

    Index Scriptorium Estoniae

    Laks, Tiiu, 1984-

    2006-01-01

    Uutest heliplaatidest Arctic Monkeys "Whatever People Say I Am", Dreamphish "Happiness Happens", Viktoria Tolstoy "My Sweadish Heart", Ursula Rucker "Ma'at Mama", Sissel "Into Paradise", Blacky "See on me meeltele", "Alternating Current 2"

  13. Savisaar sai miljonikrundi 500 000 krooniga / Tuuli Koch

    Index Scriptorium Estoniae

    Koch, Tuuli

    2005-01-01

    Majandus- ja kommunikatsiooniminister Edgar Savisaar omandas 500 000 krooni eest maatüki koos majaga Keila-Joa suvilakompleksis. Lisad: Laidoneri suvemaja ostu-müügitehing; Keila-Joa suvilakompleks

  14. Ontwikkeling van een enzyme-immuno-assay (E.I.A.) voor oestronsulfaat in bloedplasma ten behoeve van drachtigheidsdiagnose bij het varken = Development of an enzyme-immuno-assay (E.I.A.) for oestrone sulphate in bloodplasma on behalf of pregnancy diagnosis in the pig

    NARCIS (Netherlands)

    Vos, E.A.; Wiel, van de D.F.M.

    1984-01-01

    Beschrijving van de ontwikkeling van een enzymatische bepalingsmethode voor het hormoon oestronsulfaat, dat als maat voor drachtigheid gebruikt kan worden en die een goede en goedkope methode blijkt te zijn

  15. Plaadid / Tiiu Laks

    Index Scriptorium Estoniae

    Laks, Tiiu, 1984-

    2006-01-01

    Uutest heliplaatidest Arctic Monkeys "Whatever People Say I Am", Dreamphish "Happiness Happens", Viktoria Tolstoy "My Sweadish Heart", Ursula Rucker "Ma'at Mama", Sissel "Into Paradise", Blacky "See on me meeltele", "Alternating Current 2"

  16. Measuring distraction: the Peripheral Detection Task

    NARCIS (Netherlands)

    Martens, M.H.; Winsum, W. van

    2000-01-01

    Een rijsimulatorexperiment toonde aan dat de Perifere Detectie Taak een gevoelige maat is om pieken in werklast te meten, veroorzaakt door een kritische verkeerssituatie of een boodschap van een bestuurdersondersteuningssysteem.

  17. Susceptibility of the tick Haemaphysalis qinghaiensis to isolates of the fungus Metarhizium anisopliae in China.

    Science.gov (United States)

    Ren, Qiaoyun; Sun, Ming; Guan, Guiquan; Liu, Zhijie; Chen, Ze; Liu, Aihong; Li, Youquan; Ma, Miling; Yang, Jifei; Niu, Qingli; Liu, Junlong; Han, Xueqing; Yin, Hong; Luo, Jianxun

    2014-10-01

    Haemaphysalis qinghaiensis, a prevalent tick species in China, causes severe economic losses. In this study, we investigated the pathogenicity of six isolates of the fungus Metarhizium anisopliae to engorged female H. qinghaiensis using concentrations of 10(6), 10(7) and 10(8) conidia ml(-1). The results indicated that M.aAT08 and M.aAT13 isolates were highly virulent against the ticks. Metarhizium anisopliae has potential for biocontrol of H. qinghaiensis.

  18. Development of a guided bone regeneration device using salicylic acid-poly(anhydride-ester) polymers and osteoconductive scaffolds.

    Science.gov (United States)

    Mitchell, Ashley; Kim, Brian; Cottrell, Jessica; Snyder, Sabrina; Witek, Lukasz; Ricci, John; Uhrich, Kathryn E; O'Connor, J Patrick

    2014-03-01

    Successful repair of craniofacial and periodontal tissue defects ideally involves a combined therapy that includes inflammation modulation, control of soft tissue infiltration, and bone regeneration. In this study, an anti-inflammatory polymer, salicylic acid-based poly(anhydride-ester) (SAPAE) and a three-dimensional osteoconductive ceramic scaffold were evaluated as a combined guided bone regeneration (GBR) system for concurrent control of inflammation, soft tissue ingrowth, and bone repair in a rabbit cranial defect model. At time periods of 1, 3, and 8 weeks, five groups were compared: (1) scaffolds with a solid ceramic cap (as a GBR structure); (2) scaffolds with no cap; (3) scaffolds with a poly(lactide-glycolide) cap; (4) scaffolds with a slow release SAPAE polymer cap; and (5) scaffolds with a fast release SAPAE polymer cap. Cellular infiltration and bone formation in these scaffolds were evaluated to assess inflammation and bone repair capacity of the test groups. The SAPAE polymers suppressed inflammation and displayed no deleterious effect on bone formation. Additional work is warranted to optimize the anti-inflammatory action of the SAPAE, GBR suppression of soft tissue infiltration, and stimulation of bone formation in the scaffolds and create a composite device for successful repair of craniofacial and periodontal tissue defects.

  19. Physical Properties of Volcanic Deposits on Venus from Radar Polarimetry

    Science.gov (United States)

    Carter, Lynn M.; Campbell, Donald B.; Campbell, Bruce A.

    2005-01-01

    Studies of the morphology and radar properties of volcanic deposits can aid in understanding their differences and formation. On Venus, volcanoes range in size from large highland edifices, such as Theia Mons, to small shields and domes which are often found in groups of tens to hundreds. In plains regions, windstreaks are sometimes found near shield fields, suggesting that there may be fine grained deposits associated with the volcanoes. Previous studies of Bell Regio suggest the presence of fine-grained material in a low dielectric constant triangular shaped region on the flank of Tepev Mons, which may be crater ejecta or a pyroclastic deposit spread westward by wind. The eastern caldera on Tepev Mons shows a steep trend in backscattered power with incidence angle and has high RMS-slopes, implying a finegrained covering such as ash. Radar waves can easily penetrate smooth mantling layers such as ash and aeolian deposits. If a radar system can measure two orthogonal polarizations, it is possible to detect subsurface scattering and infer the presence of surficial deposits. The Magellan spacecraft could only measure one polarization and was therefore not able to fully characterize the polarization state of the radar echoes. We compare Arecibo dual-polarization data for Venus to Magellan images and emissivity data to investigate the physical properties of volcanic deposits.

  20. The rhetoric of racism: revisiting the creation of the Psychological Institute of the Republic of South Africa (1956-1962).

    Science.gov (United States)

    Long, Wahbie

    2014-01-01

    This paper revisits the 1962 splitting of the South African Psychological Association (SAPA), when disaffected Afrikaner psychologists broke away to form the whites-only Psychological Institute of the Republic of South Africa (PIRSA). It presents an analysis of the rhetorical justification for forming a new professional association on principles at odds with prevailing international norms, demonstrating how the episode involved more than the question of admitting black psychologists to the association. In particular, the paper argues that the SAPA-PIRSA separation resulted from an Afrikaner nationalist reading of the goals of psychological science. PIRSA, that is, insisted on promoting a discipline committed to the ethnic-national vision of the apartheid state. For its part, SAPA's racial integration was of a nominal order only, ostensibly to protect itself from international sanction. The paper concludes that, in a racist society, it is difficult to produce anything other than a racist psychology.

  1. Anti-apoptotic effects of Z alpha1-antitrypsin in human bronchial epithelial cells.

    LENUS (Irish Health Repository)

    Greene, C M

    2010-05-01

    alpha(1)-antitrypsin (alpha(1)-AT) deficiency is a genetic disease which manifests as early-onset emphysema or liver disease. Although the majority of alpha(1)-AT is produced by the liver, it is also produced by bronchial epithelial cells, amongst others, in the lung. Herein, we investigate the effects of mutant Z alpha(1)-AT (ZAAT) expression on apoptosis in a human bronchial epithelial cell line (16HBE14o-) and delineate the mechanisms involved. Control, M variant alpha(1)-AT (MAAT)- or ZAAT-expressing cells were assessed for apoptosis, caspase-3 activity, cell viability, phosphorylation of Bad, nuclear factor (NF)-kappaB activation and induced expression of a selection of pro- and anti-apoptotic genes. Expression of ZAAT in 16HBE14o- cells, like MAAT, inhibited basal and agonist-induced apoptosis. ZAAT expression also inhibited caspase-3 activity by 57% compared with control cells (p = 0.05) and was a more potent inhibitor than MAAT. Whilst ZAAT had no effect on the activity of Bad, its expression activated NF-kappaB-dependent gene expression above control or MAAT-expressing cells. In 16HBE14o- cells but not HEK293 cells, ZAAT upregulated expression of cIAP-1, an upstream regulator of NF-kappaB. cIAP1 expression was increased in ZAAT versus MAAT bronchial biopsies. The data suggest a novel mechanism by which ZAAT may promote human bronchial epithelial cell survival.

  2. Role and Effectiveness of Percutaneous Arterial Embolization in Hemodynamically Unstable Patients with Ruptured Splanchnic Artery Pseudoaneurysms

    Energy Technology Data Exchange (ETDEWEB)

    Dohan, Anthony, E-mail: anthony.dohan@lrb.aphp.fr [Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Department of Abdominal and Interventional Imaging (France); Eveno, Clarisse, E-mail: clarisse.eveno@lrb.aphp.fr [Université Paris-Diderot, Sorbonne Paris Cité (France); Dautry, Raphael, E-mail: raphael.dautry@lrb.aphp.fr; Guerrache, Youcef, E-mail: docyoucef05@yahoo.fr [Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Department of Abdominal and Interventional Imaging (France); Camus, Marine, E-mail: marine.camus@lrb.aphp.fr [Université Paris-Diderot, Sorbonne Paris Cité (France); Boudiaf, Mourad, E-mail: mourad.boudiaf@lrb.aphp.fr [Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Department of Abdominal and Interventional Imaging (France); Gayat, Etienne, E-mail: etienne.gayat@lrb.aphp.fr [Université Paris-Diderot, Sorbonne Paris Cité (France); Dref, Olivier Le, E-mail: olivier.ledref@lrb.aphp.fr; Sirol, Marc, E-mail: marc.sirol@lrb.aphp.fr; Soyer, Philippe, E-mail: philippe.soyer@lrb.aphp.fr [Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Department of Abdominal and Interventional Imaging (France)

    2015-08-15

    PurposeTo assess the role and effectiveness of percutaneous arterial embolization (TAE) in patients with hemodynamic instability due to hypovolemic shock secondary to ruptured splanchnic artery pseudoaneurysms (SAPA).Materials and MethodsSeventeen patients (11 men, 6 women; mean age, 53 years) with hemodynamic instability (systolic blood pressure <90 mmHg) due to hypovolemic shock secondary to ruptured SAPA were treated by TAE. Clinical files, multidetector row computed tomography angiography, and angiographic examinations along with procedure details were reviewed.ResultsSeventeen SAPAs were present, predominantly located on gastroduodenal or pancreatic arteries (9/17; 53 %). Angiography showed extravasation of contrast medium from SAPA in 15/17 patients (88 %). Technical success rate of TAE was 100 %. TAE was performed using metallic coils in all patients (100 %), in association with gelatin sponge in 5/17 patients (29 %). TAE allowed controlling the bleeding and returning to normal hemodynamic status in 16/17 patients (94 %). In 1/17 patient (6 %), surgery was needed to definitively control the bleeding. The mortality and morbidity rate of TAE at 30 days were 0 and 12 %, respectively. Morbidity consisted in coil migration in 1/17 patient (6 %) and transient serum liver enzyme elevation in 1/17 patient (6 %).ConclusionTAE is an effective and safe treatment option for ruptured SAPA in hemodynamically unstable patients, with a success rate of 94 %. Our results suggest that TAE should be the favored option in patients with hemodynamic instability due to ruptured SAPA.

  3. Dicty_cDB: VSD193 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available oideum SapA (sapA) m... 183 7e-45 BC105409_1( BC105409 |pid:none) Bos taurus prosa...posin, mRNA (cDNA ... 102 2e-20 AF108656_1( AF108656 |pid:none) Gallus gallus prosaposin mRNA, com... 99 3e...one) Homo sapiens mRNA for prosaposin v... 97 8e-19 AK223290_1( AK223290 |pid:non...e) Homo sapiens mRNA for prosaposin (... 97 8e-19 CR861454_1( CR861454 |pid:none) Pongo abelii mRNA; cDNA DK

  4. CLINICAL OBSERVATION ON TREATMENT OF 61 CASES OF INSOMNIA WITH AURICULAR PLASTER THERAPY

    Institute of Scientific and Technical Information of China (English)

    张家彤; 王月

    2003-01-01

    Objective: To observe the therapeutic effect of auricular plaster (otopoint-pressure) therapy in thetreatment of insomnia. Methods: In this paper, 61 cases of insomnia patients including 16 males and 45 females weretreated with Ershenmen (MA-TF 1), Zhen (MA-AT), Yuanzhong (MA-AT), Nao Dian and E (MA-AT), combined withother otopoints according to symptoms. The otopoint was stuck with a piece of plaster adhered with vaccaria seeds andpressured by the patient him- or her-self. The treatment was given twice a week, with 7 times being a therapeuticcourse. Results: After 1 - 2 courses of treatment, 19 (31.15%) cases were cured, 34 (55.74 % ) had improvementand 8 (13.11%) had no changes, with the total effective rate being 86.9%. Conclusion: Auricular plaster therapyworks well in the treatment of insomnia patient.

  5. Keskpolügooni umbsõlme lahendamisel viimane vaatus / Hannes Krause

    Index Scriptorium Estoniae

    Krause, Hannes

    2006-01-01

    Kaitseministeerium ja Kuusalu vald saavutasid kohtus võidu kolme maaomaniku üle, kellel on maatükk keskpolügooni alal. Kaitseministeerium peab veel läbirääkimisi 36 perekonnaga, kellele tehakse pakkumised nende maatükkide kasutusõiguse saamiseks. Vt. samas: Rein Sikk. Polügoon võttis naiselt kaks korda kodu ära. Hannes Krause. Keskpolügooni teeninduskeskuse ehitus käib juba kaks nädalat. Kaart. Kommenteerib Lauri Almann

  6. Keskpolügooni umbsõlme lahendamisel viimane vaatus / Hannes Krause

    Index Scriptorium Estoniae

    Krause, Hannes

    2006-01-01

    Kaitseministeerium ja Kuusalu vald saavutasid kohtus võidu kolme maaomaniku üle, kellel on maatükk keskpolügooni alal. Kaitseministeerium peab veel läbirääkimisi 36 perekonnaga, kellele tehakse pakkumised nende maatükkide kasutusõiguse saamiseks. Vt. samas: Rein Sikk. Polügoon võttis naiselt kaks korda kodu ära. Hannes Krause. Keskpolügooni teeninduskeskuse ehitus käib juba kaks nädalat. Kaart. Kommenteerib Lauri Almann

  7. Reliability and validity of the Farsi version of the standardized assessment of personality-abbreviated scale

    Directory of Open Access Journals (Sweden)

    Maryam Sepehri

    2017-06-01

    Full Text Available Introduction: A short screening tool for high-risk individuals with personality disorder (PD is useful both for clinicians and researchers. The aim of this study was to assess the validity and reliability of the Farsi version of the Standardized Assessment of Personality-Abbreviated Scale (SAPAS. Methods: The original English version of the SAPAS questionnaire was translated into Farsi, and then, translated back into English by two professionals. A survey was then conducted using the questionnaire on 150 clients of primary health care centers in Tabriz, Iran. A total of 235 medical students were also studied for the reliability assessment of the questionnaire. The SAPAS was compared to the short form of Minnesota Multiphasic Personality Inventory (MMPI. The data analysis was performed using receiver operating characteristic (ROC curve technique, operating characteristic for diagnostic efficacy, Cronbach's alpha, and test-retest for reliability evaluation. Results: We found an area under the curve (AUC of 0.566 [95% confidence intervals (CI: 0.455-0.677]; sensitivity of 0.89 and specificity of 0.26 at the cut-off score of 2 and higher. The total Cronbach's alpha coefficient was 0.38 and Cohen's kappa ranged between 0.5 and 0.8. Conclusion: The current study showed that the Farsi version of the SAPAS was relatively less efficient, in term of validity and reliability, in the screening of PD in the population.

  8. Zepp Grafelin on koostanud kaks näitust : ...

    Index Scriptorium Estoniae

    2004-01-01

    Meriton Grand Hotel Tallinn ruumides koostöös Eiri Foto OÜ-ga koostatud näitus "SAPA fotod mai 2004" ja Radisson SAS-i konverentsikeskuses koostöös Colorlinega koostatud näitus "Vaatega linn. City with a view" Autorid Arne Maasik ja Lembit Kibur, tootja Zepp Grafelin

  9. Increasing the Size of the Effective United States Control Fleet

    Science.gov (United States)

    2002-08-01

    Bottomed; DH – Double Hulled; SH – Single Hulled; SBT – Segregated Ballast Tanks 2. Esso Petrolera Argentina SRL ( Sociedad de Responsabilidad Limitada ...new name for Esso SAPA ( Sociedad Anonima Petrolera Argentin) Source: Appendix E Table 5.2, M.I.T. EUSC, Militarily Useful Tanker Fleet for June 2002 85

  10. The Self-report Standardized Assessment of Personality-abbreviated Scale: Preliminary results of a brief screening test for personality disorders

    NARCIS (Netherlands)

    Germans, S.; Heck, G.L. van; Moran, P.; Hodiamont, P.P.G.

    2009-01-01

    Objective The internal consistency, test-retest reliability and validity of the Self-report Standardized Assessment of Personality-abbreviated Scale (SAPAS-SR) as a screening instrument for personality disorders were studied in a random sample of 195 Dutch psychiatric outpatients, using the Structu

  11. Service-Oriented Resource Allocation in Clouds:Pursuing Flexibility and Efficiency

    Institute of Scientific and Technical Information of China (English)

    张胜; 钱柱中; 吴杰; 陆桑璐

    2015-01-01

    The networking-oblivious resource reservation model in today’s public clouds cannot guarantee the performance of tenants’ applications. Virtual networks that capture both computing and networking resource requirements of tenants have been proposed as better interfaces between cloud providers and tenants. In this paper, we propose a novel virtual network model that could specify not only absolute and relative location requirements but also time-varying resource demands. Building on top of our model, we study how to efficiently and flexibly place multiple virtual networks in a cloud, and we propose two algorithms, MIPA and SAPA, which focus on optimizing resource utilization and providing flexible placement, respectively. The mixed integer programming based MIPA transforms the placement problem into the multi-commodity flow problem through augmenting the physical network with shadow nodes and links. The simulated annealing-based SAPA achieves resource utilization efficiency through opportunistically sharing physical resources among multiple resource demands. Besides, SAPA allows cloud providers to control the trade-offs between performance guarantee and resource utilization, and between allocation optimality and running time, and allows tenants to control the trade-off between application performance and placement cost. Extensive simulation results confirm the efficiency of MIPA in resource utilization and the flexibility of SAPA in controlling trade-offs.

  12. Campylobacter fetus surface layer proteins are transported by a type I secretion system.

    Science.gov (United States)

    Thompson, S A; Shedd, O L; Ray, K C; Beins, M H; Jorgensen, J P; Blaser, M J

    1998-12-01

    The virulence of Campylobacter fetus, a bacterial pathogen of ungulates and humans, is mediated in part by the presence of a paracrystalline surface layer (S-layer) that confers serum resistance. The subunits of the S-layer are S-layer proteins (SLPs) that are secreted in the absence of an N-terminal signal sequence and attach to either type A or B C. fetus lipopolysaccharide in a serospecific manner. Antigenic variation of multiple SLPs (encoded by sapA homologs) of type A strain 23D occurs by inversion of a promoter-containing DNA element flanked by two sapA homologs. Cloning and sequencing of the entire 6.2-kb invertible region from C. fetus 23D revealed a probable 5.6-kb operon of four overlapping genes (sapCDEF, with sizes of 1,035, 1,752, 1,284, and 1,302 bp, respectively) transcribed in the opposite direction from sapA. The four genes also were present in the invertible region of type B strain 84-107 and were virtually identical to their counterparts in the type A strain. Although SapC had no database homologies, SapD, SapE, and SapF had predicted amino acid homologies with type I protein secretion systems (typified by Escherichia coli HlyBD/TolC or Erwinia chrysanthemi PrtDEF) that utilize C-terminal secretion signals to mediate the secretion of hemolysins, leukotoxins, or proteases from other bacterial species. Analysis of the C termini of four C. fetus SLPs revealed conserved structures that are potential secretion signals. A C. fetus sapD mutant neither produced nor secreted SLPs. E. coli expressing C. fetus sapA and sapCDEF secreted SapA, indicating that the sapCDEF genes are sufficient for SLP secretion. C. fetus SLPs therefore are transported to the cell surface by a type I secretion system.

  13. Dry bone histology : technicalities, diagnostic value and new applications

    NARCIS (Netherlands)

    Boer, Hans Henk de

    2014-01-01

    This thesis presents an easy, rapid and inexpensive supplement to the well-known method of Maat et al. (2001). This new method allows for the histochemical staining of dry bone material, enhancing the visibility of important hallmarks of dry bone histomorphology. In addition, this thesis provides a

  14. Maastikusõiduk UTV aitab tööd teha ja lõõgastuda / Ain Alvela ; kommenteerinud Tanel Rütman

    Index Scriptorium Estoniae

    Alvela, Ain, 1967-

    2015-01-01

    Analoogselt ATVga (ingl k All Terrain Vehicle - iga maastiku sõiduk) võib ka UTVd (ingl k Utility Terrain Vehicle - vahend maastikul liikumiseks) käsitleda nii tarbesõidukina väiksemate maatööde tegemiseks või raskestiläbitaval maastikul liikumiseks kui ka lihtsalt adrenaliinilaksu pakkuva meelelahutajana

  15. Kõik mehed on vist sead? / Kristel Kirss

    Index Scriptorium Estoniae

    Kirss, Kristel, 1967-

    2003-01-01

    Arvustus: O'Brien, Edna. Maatüdrukud : [romaan] / tõlkinud [ja järelsõna:] Sirje Leol. Tallinn : Eesti Raamat, c2002 ; O'Brien, Edna. Üksildane tüdruk : [triloogia 2. osa] ; Tüdrukud abielutaevas : [triloogia 3. osa] / tõlkinud Sirje Leol. Tallinn : Eesti Raamat, 2003

  16. Rae vald riskib vastu tulles / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2005-01-01

    Edgar Savisaare firma Fixor Holding sai Rae vallalt pikendust enampakkumisele pandud maatüki ostu-müügitehingu sõlmimiseks. Enampakkumisel teiseks jäänud Eesti Tarbijate Keskühistu veel kaalub, kas esitada vallale kahjutasunõue. Kommenteerib Urmas Volens

  17. Talunikel võimalus maid ise mõõta / Kai Simson

    Index Scriptorium Estoniae

    Simson, Kai

    2005-01-01

    Estpit Projekt võitis maatükkide mõõtmise mobiilse GPS-lahendusega Põllumajanduse Registrite ja Informatsiooni Ameti avatud riigihanke. Tarkvara saab kasutada lisaks maamõõtmisele ka põllutööde jälgimiseks

  18. Rae vald riskib vastu tulles / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2005-01-01

    Edgar Savisaare firma Fixor Holding sai Rae vallalt pikendust enampakkumisele pandud maatüki ostu-müügitehingu sõlmimiseks. Enampakkumisel teiseks jäänud Eesti Tarbijate Keskühistu veel kaalub, kas esitada vallale kahjutasunõue. Kommenteerib Urmas Volens

  19. Treatment of Facial Chloasma by Auricular Pressure in41 Cases

    Institute of Scientific and Technical Information of China (English)

    LIU Guang-xia; XIAO Yuan-chun

    2003-01-01

    According to differentiating syndrome and dividing patter, 41 cases of Facial Chloasma by Auricular Pressure in Shen ( MA-AH), Fei ( MA-IC 1 ), Neifenmi ( MA-IC 3 ), Luanchao ( MA-AT), Mianjia (MA-L) and Xia' erbei(MA-IC), the total effective rate was 87.8%.

  20. Bacterial GDGTs in Holocene sediments and catchment soils of a high Alpine lake: application of the MBT/CBT-paleothermometer

    NARCIS (Netherlands)

    Niemann, H.; Stadnitskaia, A.; Wirth, S.B.; Gilli, A.; Anselmetti, F.S.; Sinninghe Damsté, J.S.S.; Schouten, S.; Hopmans, E.C.; Lehmann, M.F.

    2012-01-01

    A novel proxy for continental mean annual air temperature (MAAT) and soil pH, the MBT/CBT-paleothermometer, is based on the temperature (T) and pH-dependent distribution of specific bacterial membrane lipids (branched glycerol dialkyl glycerol tetraethers - GDGTs) in soil organic matter. Here, we te

  1. Propavshije bez vesti / Virkko Lepassalu

    Index Scriptorium Estoniae

    Lepassalu, Virkko, 1971-

    2004-01-01

    Kaks Tallinnas Pirita lähistel asuvate hinnaliste maatükkide omanikku on kadunud. Autor arvab, et mõlema inimese kadumisest peaks teadma Rahvaliidu poliitik Jossif Eidelkind. Lisad. Ajalehe poolt esitatud küsimused ja Jossif Eidelkindi elektronkiri

  2. Erakordelt ropp lugu / Keit Pentus

    Index Scriptorium Estoniae

    Pentus, Keit, 1976-

    2006-01-01

    Tallinna linnavolikogu Reformierakonna fraktsiooni juhi kriitika Tallinna linnavalitsuse aadressil, kes on nõus Harju tänaval paiknevate kruntide eest maksma 150 miljonit krooni, samas kui hindamisakti järgi on maatüki tegelik väärtus vaid 74,8 miljonit krooni

  3. Onderzoek naar de concentraties in bloed van pentachloorfenol (PCP) en gamma-hexachloorcyclohexaan (gamma-HCH) van bewoners en toekomstige bewoners van een gerenoveerd pakhuis te Amsterdam

    NARCIS (Netherlands)

    Remmert HP; van den Doel R; Hofstee AWM; Meulenbelt J; Greve PA; Slob W; Meyer HHP; van den Boogert ALF; Savelkoul TJF

    1987-01-01

    Bij huidige en toekomstige bewoners van een gerenoveerd pakhuis te Amsterdam waarvan houten balken bewerkt waren met PCP en gamma-HCH, werd een onderzoek verricht naar de concentraties van deze stoffen in het bloed als maat voor de lichaamsbelasting. Tussen de beide groepen werd geen statistisch si

  4. Солдата хотят купить / Александр Чаплыгин

    Index Scriptorium Estoniae

    Чаплыгин, Александр, 1964-

    2007-01-01

    Vene ärimees ja Riigiduuma saadik, partei Ühtne Venemaa (Jedinaja Rossija) liige Aleksandr Lebedev saatis president Toomas Hendrik Ilvesele kirja, milles avaldas soovi ära osta Tallinnas Tõnismäel asuv maatükk, kus asub pronkssõduri monument. Tallinna abilinnapea Olga Sõtniku arvamus. Vt. samas: Öine vahtkond hoiatas; Riigiduuma teeb ettepaneku sanktsioonideks

  5. Dynamisch internetten

    NARCIS (Netherlands)

    drs. Frans van den Reep

    2006-01-01

    Heeft Web 2.0 de toekomst? Of is het het zoveelste buzzword dat vooral in marketingkringen leeft? Onder Web 2.0 worden dynamische internetsites verstaan. In veel gevallen gebruiken die sites programmeertechnieken waarmee rap op maat gemaakte sites zijn op te bouwen. Die putten daarvoor weer informat

  6. Uitwerking Richtsnoer 'Enuresis nocturna' voor kinderen met hardnekkige klachten [Further development of 'Enuresis nocturna' guidelines for children with persistent problems

    NARCIS (Netherlands)

    Hirasing, R.A.; Leerdam, F.J.M. van; Sukhai, R.N.; Capelle, J.W. van; Froeling, F.M.J.A.; Vijverberg, M.A.W.

    2004-01-01

    Om een kind met hardnekkige klachten van enuresis nocturna droog te krijgen, is het van belang om na te gaan welke factoren een rol spelen bij het bedplassen en waarom eerdere behandeling is mislukt. Het gebruik van een mictielijst is hierbij onmisbaar. De behandeling moet op maat worden gegeven. De

  7. Dry bone histology : technicalities, diagnostic value and new applications

    NARCIS (Netherlands)

    Boer, Hans Henk de

    2014-01-01

    This thesis presents an easy, rapid and inexpensive supplement to the well-known method of Maat et al. (2001). This new method allows for the histochemical staining of dry bone material, enhancing the visibility of important hallmarks of dry bone histomorphology. In addition, this thesis provides a

  8. Europan - võimalus noortele arhitektidele / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    2004-01-01

    Üleeuroopaline elamuehituse ja planeerimisteemaline konkurss Europan 7 teemal "Äärelinna võimalus". Eesti osales kahe võistlusalaga: maatükk Tallinnas Lasnamäe veerul ning mereäärne krunt Pärnus. Võidutööde arhitektide loetelu ja tööde kirjeldus

  9. Transport of branched tetraether lipids from the Tagus River basin to the coastal ocean of the Portuguese margin : Consequences for the interpretation of the MBT'/CBT paleothermometer

    NARCIS (Netherlands)

    Zell, C.; Kim, J. H.; Balsinha, M.; Dorhout, D.; Fernandes, C.; Baas, M.; Sinninghe Damsté, J. S.|info:eu-repo/dai/nl/07401370X

    2014-01-01

    Branched glycerol dialkyl glycerol tetraethers (brGDGTs), which are thought to be transported from soil to marine sediment by rivers, have been used to reconstruct the mean annual air temperature (MAAT) and soil pH of the drainage basin using the methylation index of branched tetraethers (MBT, recen

  10. Transport of branched tetraether lipids from the Tagus River basin to the coastal ocean of the Portuguese margin: consequences for the interpretation of the MBT’/CBT paleothermometer

    NARCIS (Netherlands)

    Zell, C.; Kim, J.H.; Balsinha, M.; Dorhout, D.; Fernandes, C.; Baas, M.; Sinninghe Damsté, J.S.

    2014-01-01

    Branched glycerol dialkyl glycerol tetraethers (brGDGTs), which are transported from soil to marine sediment by rivers, have been used to reconstruct the mean annual air temperature (MAAT) and soil pH of the drainage basin using the methylation index of branched tetraethers (MBT, recently refined as

  11. Maastikusõiduk UTV aitab tööd teha ja lõõgastuda / Ain Alvela ; kommenteerinud Tanel Rütman

    Index Scriptorium Estoniae

    Alvela, Ain, 1967-

    2015-01-01

    Analoogselt ATVga (ingl k All Terrain Vehicle - iga maastiku sõiduk) võib ka UTVd (ingl k Utility Terrain Vehicle - vahend maastikul liikumiseks) käsitleda nii tarbesõidukina väiksemate maatööde tegemiseks või raskestiläbitaval maastikul liikumiseks kui ka lihtsalt adrenaliinilaksu pakkuva meelelahutajana

  12. Een analyse van winsommen van Nederlandse dravers, geboren tussen 1959 en 1971 = An analysis of earnings of Dutch trotters, born between 1959 and 1971

    NARCIS (Netherlands)

    Minkema, D.

    1982-01-01

    Bij de selektie van draverfokhengsten wordt door de Stichting Nederlandse Draf- en Rensport gebruik gemaakt van een fokwaarde-index. Deze index, gebaseerd op de winsommen van de nakomelingen van de hengsten, is een maat voor de fokwaarde der hengsten voor prestatievermogen. De berekening van de fokw

  13. Sources of core and intact branched tetraether membrane lipids in the lacustrine environment: Anatomy of Lake Challa and its catchment, equatorial East Africa

    NARCIS (Netherlands)

    Buckles, L.K.; Weijers, J.W.H.; Verschuren, D.; Sinninghe Damsté, J.S.

    2014-01-01

    The MBT/CBT palaeotemperature proxy uses the distribution of branched glycerol dialkyl glycerol tetraethers (brGDGTs), membrane lipids that are supposed to derive from soil bacteria, to reconstruct mean annual air temperature (MAAT). Applied successfully in coastal marine sediments, its extension to

  14. Viimsi võimuvahetus käib ärevalt / Anneli Ammas

    Index Scriptorium Estoniae

    Ammas, Anneli, 1962-

    2005-01-01

    Väidetavalt üritab sihtasutus Rohuneeme Puhkekeskus vormistada 125 ha suurusele hinnalise maatükile Viimsis kiiruga hoonestusõigust. Senised opositsionäärid vallas aga ei tea, kelle kasuks. Kelvingi külavanem Ants-Hembo Lindemann on kogunud Viimsis 1700 allkirja metsamaa kaitseks. Kaart: Viimsi pahandused

  15. Tartu uudismajad : vol. 3 / Aleksander Tsapov

    Index Scriptorium Estoniae

    Tsapov, Aleksander

    2007-01-01

    Tartu uutest korterelamutest: Ranna tee 1, Ülejõe (arhitekt Ott Ojamaa, valminud 2006), Raatuse 86, Ülejõe (arhitekt Aigar Roht, valminud 2005), Kroonuaia 32, Supilinn (valminud 2006), Aleksandri 35, Karlova (AB Salto, valmib 2007), Selleri 10, Supilinn (arhitektid Indrek Mikk, Janek Maat, valminud 2006)

  16. Mental problems among first-year conservatory students compared with medical students.

    Science.gov (United States)

    van Fenema, E M; van Geel, C C J

    2014-06-01

    Musical education and the musical profession can be stressful, which may make musicians vulnerable for stress-related disorders. To determine if music students are particularly at risk for mental problems, we used the Standardised Assessment of Personality-Abbreviated Scale (SAPAS) and the Symptom Questionnaire (SQ48S) to compare symptoms in first-year conservatory students (n=33) and first-year medical students (n=43). On the SAPAS, we found that medical students have significantly more difficulty making and keeping friends (p=0.015). Also, we observed a trend that conservatory students lose their temper more easily (p=0.040). Both student groups showed high scores for the personality trait "perfectionism." On the SQ48, we observed a trend that both conservatory and medical students experience more psychological problems than the general population, but there were no significant differences between conservatory students and medical students in the total scores of both questionnaires.

  17. Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina.

    Science.gov (United States)

    Mallimaci, María Cristina; Sosa-Estani, Sergio; Russomando, Graciela; Sanchez, Zunilda; Sijvarger, Carina; Alvarez, Isabel Marcela; Barrionuevo, Lola; Lopez, Carlos; Segura, Elsa Leonor

    2010-01-01

    Chagas' disease, or American trypanosomiasis, is caused by the protozoan parasite Trypanasoma cruzi. It is estimated that 15,000 new cases of congenital T. cruzi transmission occur in the Americas each year. The aim of this study was to estimate the rate of congenital T. cruzi infection in infants born to infected women living in Ushuaia, Argentina, as well to assess a serologic test using Shed Acute Phase Antigen (SAPA) for a timely diagnosis of congenital infection. The rate of congenital infection among children in the study was 4.4% (3/68). Our results show that for infants younger than 30 days of age, matched blood samples from mother and infant were capable of identifying congenital transmission of infection using an enzyme-linked immunosorbent assay with SAPA. For infants older than 3 months, congenital infection could be ruled out using the same procedure.

  18. Dicty_cDB: [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VF (Link to library) VFB595 (Link to dictyBase) - - - Contig-U09552-1 VFB595E (Link...) Clone ID VFB595 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U09552-1 Ori...KLLKSDNWISTCQNLIQEYEPQ IIAVVEGFMAPSELCQKIKFCSSSSSTNDFDFIGSSTTDCEICTFISGYAENFLEENKTL EDIIKVVDDFCKILPAAYKTDCVA...A: VEGSGECLVCEFISEKIVTYLEANQTETQILQYLDNDCKLLKSDNWISTCQNLIQEYEPQ IIAVVEGFMAPSELCQKIKFCSSSSSTNDFDFIGSSTTDCEICT... Sequences producing significant alignments: (bits) Value N U66367 |U66367.1 Dictyostelium discoideum SapA (

  19. JPRS Report, Environmental Issues

    Science.gov (United States)

    1990-11-14

    Minister Issues ’Strong Warning’ on Gill Nets [Johannesburg Radio 18 Oct] 11 Health Minister on Plan for Protection of Ozone Layer [SAPA 18 Oct...government for Finnish beer, Scotch whisky , and Finnish meatballs. The hosts proudly displayed their state-of-the-art gadgets. Scientists who had...No one expects a breakthrough at the conference that would lead to swift actions to benefit the Baltic. Of the Baltic countries, Estonia and Latvia

  20. Sub-Saharan Africa Report

    Science.gov (United States)

    2007-11-02

    Stirling ; THE CITIZEN, 15 Aug 86) .. 53 Rightwing Parties Meet in Pretoria (SAPA, 12 Aug 86) • • • • 54 BLACKS ANC’s Maharaj on Consolidating...Article by Tony Stirling ] [Text] Strong speculation exists in informed government circles in Pretoria that certain urban areas in South Africa which...Angola. Conservative estimates put the expenses Incurred by the Boers in Namibia because of the war at 1 million rand a day. This sky high war budget

  1. Therapeutic Observation on Treatment of Enuresis with Combined Auricular Pressure and Tuina

    Institute of Scientific and Technical Information of China (English)

    王秋景; 刘玉泉; 王山

    2006-01-01

    Ninety-two cases of enuresis were treated with auricular point pressure onthe kidney (MA-SC), bladder (MA-SC 8), lung (MA-IC 1), heart (MA-IC), liver (MA-SC 5), Er Shenmen(MA-TF 1),Zhen (MA-AT) and Subcortex (MA-AT 1) plus tuina. After treatment, 61 cases were cured, 28 cases were effective and 3 cases were ineffective, with an effective rate of 96.7%.%贴压耳穴肾、膀胱、肺、心、肝、神门、枕和皮质下,结合推拿疗法,治疗了92例遗尿症患者,经治疗后痊愈61例,好转28例,无效3例,有效率96.7%.

  2. Suurhalli omanikud kavandavad selle juurde spordirajatisi ja kortereid / Urmas Seaver

    Index Scriptorium Estoniae

    Seaver, Urmas, 1973-

    2006-01-01

    Ilmunud ka: Postimees : na russkom jazõke 28. veebr. lk. 8. Rocca al Mare suurhalli omanikud Oliver Kruuda ja Marcel Vichmann soovivad halli taha, riigile kuuluvale 26-hektarilisele maatükile rajada uue spordihalli, veekeskuse, teater-kino ja kortermaju. Suurhalli tegevjuhi Aivar Sirelpuu sõnul ootab halli juhtkond praegu linna ja riigi seisukohta nende plaanide suhtes. Kaart: Rocca al Mare suurhall

  3. Disease: H01365 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H01365 Leber hereditary optic neuropathy and dystonia (LDYT) Leber hereditary optic...ociated with maternally inherited Leber hereditary optic neuropathy and dystonia. Proc Natl Acad Sci U S A 9...o J, Lou JN, Tsuji S Mitochondrial ND3 as the novel causative gene for Leber hereditary optic neuropathy and...MW, Maat-Kievit A, Schoonderwoerd KC, Sluiter W, de Coo IF, Hintzen RQ A MELAS-associated ND1 mutation causing leber

  4. Permafrost Distribution Modeling in the Semi-Arid Chilean Andes

    OpenAIRE

    Azócar, Guillermo F.; Brenning, Alexander; Bodin, Xavier

    2016-01-01

    Mountain permafrost and rock glaciers in the dry Andes are of growing interest due to the increase in human activities in this remote area. Empirical models of mountain permafrost distribution based on the spatial analysis of intact and relict rock glaciers and mean annual air temperature (MAAT) have been established as a tool for regional-scale assessments of permafrost favorability across entire mountain ranges; however, this kind of model approach has never been applied for a large portion...

  5. Increased outer arm and core fucose residues on the N-glycans of mutated alpha-1 antitrypsin protein from alpha-1 antitrypsin deficient individuals.

    Science.gov (United States)

    McCarthy, Cormac; Saldova, Radka; O'Brien, M Emmet; Bergin, David A; Carroll, Tomás P; Keenan, Joanne; Meleady, Paula; Henry, Michael; Clynes, Martin; Rudd, Pauline M; Reeves, Emer P; McElvaney, Noel G

    2014-02-01

    Alpha-1 antitrypsin (AAT) is the major physiological inhibitor of a range of serine proteases, and in the lung, it maintains a protease-antiprotease balance. AAT deficiency (AATD) is an autosomal co-dominant condition with the Z mutation being the most common cause. Individuals homozygous for Z (PiZZ) have low levels of circulating mutant Z-AAT protein leading to premature emphysematous lung disease. Extensive glycoanalysis has been performed on normal AAT (M-AAT) from healthy individuals and the importance of glycosylation in affecting the immune modulatory roles of AAT is documented. However, no glycoanalysis has been carried out on Z-AAT from deficient individuals to date. In this study, we investigate whether the glycans present on Z-AAT differ to those found on M-AAT from healthy controls. Plasma AAT was purified from 10 individuals: 5 AATD donors with the PiZZ phenotype and 5 PiMM healthy controls. Glycoanalysis was performed employing N-glycan release, exoglycosidase digestion and UPLC analysis. No difference in branched glycans was identified between AATD and healthy controls. However, a significant increase in both outer arm (α1-3) (p = 0.04) and core (α1-6) fucosylated glycans (p < 0.0001) was found on Z-AAT compared to M-AAT. This study has identified increased fucosylation on N-glycans of Z-AAT indicative of ongoing inflammation in AATD individuals with implications for early therapeutic intervention.

  6. Tectonic Evolution of Bell Regio, Venus: Regional Stress, Lithospheric Flexure, and Edifice Stresses

    Science.gov (United States)

    Rogers, P. G.; Zuber, M. T.

    1996-03-01

    Analyses of the tectonic features associated with large volcanoes provide important insight into the relationship between volcanic and tectonic processes and the stress state of a planet's crust over time, and provide constraints on the local and regional geologic evolution. This investigation focuses on the tectonism and volcanism of Bell Regio, a major highland uplift n Venus. The stress environments and resulting tectonic features associated with the major volcanic edifices in this region are examined using Magellan ynthetic aperture radar (SAR) images and altimeter measurements of topography. The major volcanoes of Bell Regio, Tepev Mons and the "Eastern Volcanic Center" (EVC), exhibit tectonic characteristics that are unique relative to other volcanic edifices on Venus. The most prominent distinctions are the lack of large rift zones within the overall highland uplift and the presence of radial tectonic and concentric fractures associated with the major edifices. This study examines the regional stress field in Bell Regio through analysis of structural features believed to be a consequence of lithospheric flexure due to volcanic loading and tectonic features that likely resulted from edifice stresses associated with magma chamber inflation.

  7. Analysis and Simulation of the Simplified Aircraft-Based Paired Approach Concept With the ALAS Alerting Algorithm in Conjunction With Echelon and Offset Strategies

    Science.gov (United States)

    Torres-Pomales, Wilfredo; Madden, Michael M.; Butler, Rickey W.; Perry, Raleigh B.

    2014-01-01

    This report presents analytical and simulation results of an investigation into proposed operational concepts for closely spaced parallel runways, including the Simplified Aircraft-based Paired Approach (SAPA) with alerting and an escape maneuver, MITRE?s echelon spacing and no escape maneuver, and a hybrid concept aimed at lowering the visibility minima. We found that the SAPA procedure can be used at 950 ft separations or higher with next-generation avionics and that 1150 ft separations or higher is feasible with current-rule compliant ADS-B OUT. An additional 50 ft reduction in runway separation for the SAPA procedure is possible if different glideslopes are used. For the echelon concept we determined that current generation aircraft cannot conduct paired approaches on parallel paths using echelon spacing on runways less than 1400 ft apart and next-generation aircraft will not be able to conduct paired approach on runways less than 1050 ft apart. The hybrid concept added alerting and an escape maneuver starting 1 NM from the threshold when flying the echelon concept. This combination was found to be effective, but the probability of a collision can be seriously impacted if the turn component of the escape maneuver has to be disengaged near the ground (e.g. 300 ft or below) due to airport buildings and surrounding terrain. We also found that stabilizing the approach path in the straight-in segment was only possible if the merge point was at least 1.5 to 2 NM from the threshold unless the total system error can be sufficiently constrained on the offset path and final turn.

  8. A statistical permafrost distribution model for the European Alps

    Directory of Open Access Journals (Sweden)

    L. Boeckli

    2011-05-01

    Full Text Available Permafrost distribution modeling in densely populated mountain regions is an important task to support the construction of infrastructure and for the assessment of climate change effects on permafrost and related natural systems. In order to analyze permafrost distribution and evolution on an Alpine-wide scale, one consistent model for the entire domain is needed.

    We present a statistical permafrost model for the entire Alps based on rock glacier inventories and rock surface temperatures. Starting from an integrated model framework, two different sub-models were developed, one for debris covered areas (debris model and one for steep rock faces (rock model. For the debris model a generalized linear mixed-effect model (GLMM was used to predict the probability of a rock glacier being intact as opposed to relict. The model is based on the explanatory variables mean annual air temperature (MAAT, potential incoming solar radiation (PISR and the mean annual sum of precipitation (PRECIP, and achieves an excellent discrimination (area under the receiver-operating characteristic, AUROC = 0.91. Surprisingly, the probability of a rock glacier being intact is positively associated with increasing PRECIP for given MAAT and PISR conditions. The rock model was calibrated with mean annual rock surface temperatures (MARST and is based on MAAT and PISR. The linear regression achieves a root mean square error (RMSE of 1.6 °C. The final model combines the two sub-models and accounts for the different scales used for model calibration. Further steps to transfer this model into a map-based product are outlined.

  9. Sustained miRNA-mediated knockdown of mutant AAT with simultaneous augmentation of wild-type AAT has minimal effect on global liver miRNA profiles.

    Science.gov (United States)

    Mueller, Christian; Tang, Qiushi; Gruntman, Alisha; Blomenkamp, Keith; Teckman, Jeffery; Song, Lina; Zamore, Phillip D; Flotte, Terence R

    2012-03-01

    α-1 antitrypsin (AAT) deficiency can exhibit two pathologic states: a lung disease that is primarily due to the loss of AAT's antiprotease function, and a liver disease resulting from a toxic gain-of-function of the PiZ-AAT (Z-AAT) mutant protein. We have developed several recombinant adeno-associated virus (rAAV) vectors that incorporate microRNA (miRNA) sequences targeting the AAT gene while also driving the expression of miRNA-resistant wild-type AAT-PiM (M-AAT) gene, thus achieving concomitant Z-AAT knockdown in the liver and increased expression of M-AAT. Transgenic mice expressing the human PiZ allele treated with dual-function rAAV9 vectors showed that serum PiZ was stably and persistently reduced by an average of 80%. Treated animals showed knockdown of Z-AAT in liver and serum with concomitant increased serum M-AAT as determined by allele-specific enzyme-linked immunosorbent assays (ELISAs). In addition, decreased globular accumulation of misfolded Z-AAT in hepatocytes and a reduction in inflammatory infiltrates in the liver was observed. Results from microarray studies demonstrate that endogenous miRNAs were minimally affected by this treatment. These data suggests that miRNA mediated knockdown does not saturate the miRNA pathway as has been seen with viral vector expression of short hairpin RNAs (shRNAs). This safe dual-therapy approach can be applied to other disorders such as amyotrophic lateral sclerosis, Huntington disease, cerebral ataxia, and optic atrophies.

  10. Periglacial processes incorporated into a long-term landscape evolution model

    DEFF Research Database (Denmark)

    Andersen, Jane Lund; Egholm, D.L.; Knudsen, Mads Faurschou

    relating frost-cracking intensity to the mean annual air temperature (MAAT). The model integrates temperature variations in the subsurface following an annually oscillating surface temperature. Hales and Roering (2007) assumed that frost-cracking intensity is a simple function of the temperature gradient...... allows us to couple the frost-cracking model to a long- term landscape evolution model where surface elevation, sediment thickness, and air temperature evolve through time. This enables us to explore the spatial distribution of frost cracking in realistic landscapes, and to study the slow feedbacks...

  11. 3T3 fibroblasts transfected with a cDNA for mitochondrial aspartate aminotransferase express plasma membrane fatty acid-binding protein and saturable fatty acid uptake.

    OpenAIRE

    1995-01-01

    To explore the relationship between mitochondrial aspartate aminotransferase (mAspAT; EC 2.6.1.1) and plasma membrane fatty acid-binding protein (FABPpm) and their role in cellular fatty acid uptake, 3T3 fibroblasts were cotransfected with plasmid pMAAT2, containing a full-length mAspAT cDNA downstream of a Zn(2+)-inducible metallothionein promoter, and pFR400, which conveys methotrexate resistance. Transfectants were selected in methotrexate, cloned, and exposed to increasing methotrexate co...

  12. A naturally-occurring ‘cold earth’ spot in Northern China

    OpenAIRE

    Fujun Niu; Guodong Cheng; Yonghong Niu; Mingyi Zhang; Jing Luo; Zhanju Lin

    2016-01-01

    Permafrost is determined to a large extent by the Earth’s surface temperature, therefore it distributes mainly in high altitude and latitude regions. However, stable, warm (about −1 °C) permafrost occurs within a scree slope in northern China that is more than 600 km south of the southernmost limit of latitudinal permafrost on the Eurasian Continent. It is at an elevation of only 900 m above sea level (ASL). The area has a mean annual air temperature (MAAT) of 6 to 8 °C. Thermal processes of ...

  13. Reconstrucció de les temperatures superficials de l'aigua i de l'aire del Skagerrak (Escandinàvia) dels darrers 2000 anys

    OpenAIRE

    Rueda Ferrer, Gemma

    2007-01-01

    S'han utilitzat uns proxies nous per a estimar les temperatures superficials de l'aigua i de l'aire dels darrers 2000 anys de la zona de l'estret del Skagerrak per tal d'estudiar l'evolució del clima en aquesta zona i comparar-la amb la tendència del pal d'hoquei observada en diversos registres de l'hemisferi Nord. Els proxies utilitzats estan basats el els GDGTS i són el TEX86, que permet estimar la SST, el MAAT que permet estimar la temperatura mitjana anual de l'aire, el BIT que permet est...

  14. Nõelasilma umbsõlme lahendused: muld või kuld : Värske kohtuotsuse järgi peab linn Trepi tänavas oleva tugimüüri lammutama ja eraomanduses oleval krundil esialgse olukorra taastama / Ants Vill

    Index Scriptorium Estoniae

    Vill, Ants, 1955-

    2012-01-01

    Kohtuvaidlusest linna ja OÜ Uranuse juhatuse liikme Heino Viigi vahel. Riigikohtu tsiviilkolleegiumi otsus kohustab linna lammutama Niguliste kiriku juures Harju tänava haljastul Trepi tänavat Vabaduse väljaku poolselt küljelt varingute eest kaitsva tugimüüri ning taastatud Nõelasilma väravat veidi Raekoja platsi poole nihutama. Maaomanik OÜ Uranos nõuab kohtuotsuse täitmist, kuid on nõus ka maatükki müüma ligi 2,5 miljoni euroga

  15. Гордиев узел в самом сердце Таллинна : Согласно недавнему решению суда Таллинн должен разрушить находящиеся в районе бывшей улицы Трепи

    Index Scriptorium Estoniae

    Вилл, Антс, 1955-

    2012-01-01

    Kohtuvaidlusest linna ja OÜ Uranuse juhatuse liikme Heino Viigi vahel. Riigikohtu tsiviilkolleegiumi otsus kohustab linna lammutama Niguliste kiriku juures Harju tänava haljastul Trepi tänavat Vabaduse väljaku poolselt küljelt varingute eest kaitsva tugimüüri ning taastatud Nõelasilma väravat veidi Raekoja platsi poole nihutama. Maaomanik OÜ Uranos nõuab kohtuotsuse täitmist, kuid on nõus ka maatükki müüma ligi 2,5 miljoni euroga

  16. Predicted structure of two adenovirus tumor antigens.

    OpenAIRE

    Perricaudet, M; Le Moullec, J M; Pettersson, U

    1980-01-01

    Early adenovirus type 2(Ad2) mRNA sequences have been cloned by using the pBR322 plasmid as a vector. Two clones that include sequences from region E1B were identified and their DNAs were characterized by hybridization, restriction enzyme cleavage, and DNA sequence analysis. The results showed that the clones were derived from two different spliced mRNAs. By combining our results with the established DNA sequence for region E1B of the closely related adenovirus type 5[Maat, J., van Beveren, C...

  17. Locally delivered salicylic acid from a poly(anhydride-ester): impact on diabetic bone regeneration.

    Science.gov (United States)

    Wada, Keisuke; Yu, Weiling; Elazizi, Mohamad; Barakat, Sandrine; Ouimet, Michelle A; Rosario-Meléndez, Roselin; Fiorellini, Joseph P; Graves, Dana T; Uhrich, Kathryn E

    2013-10-10

    Diabetes mellitus (DM) involves metabolic changes that can impair bone repair, including a prolonged inflammatory response. A salicylic acid-based poly(anhydride-ester) (SA-PAE) provides controlled and sustained release of salicylic acid (SA) that locally resolves inflammation. This study investigates the effect of polymer-controlled SA release on bone regeneration in diabetic rats where enhanced inflammation is expected. Fifty-six Sprague-Dawley rats were randomly assigned to two groups: diabetic group induced by streptozotocin (STZ) injection or normoglycemic controls injected with citrate buffer alone. Three weeks after hyperglycemia development or vehicle injection, 5mm critical sized defects were created at the rat mandibular angle and treated with SA-PAE/bone graft mixture or bone graft alone. Rats were euthanized 4 and 12weeks after surgery, then bone fill percentage in the defect region was assessed by micro-computed tomography (CT) and histomorphometry. It was observed that bone fill increased significantly at 4 and 12weeks in SA-PAE/bone graft-treated diabetic rats compared to diabetic rats receiving bone graft alone. Accelerated bone formation in normoglycemic rats caused by SA-PAE/bone graft treatment was observed at 4weeks but not at 12weeks. This study shows that treatment with SA-PAE enhances bone regeneration in diabetic rats and accelerates bone regeneration in normoglycemic animals.

  18. Changes of soil thermal and hydraulic regimes in the Heihe River Basin.

    Science.gov (United States)

    Peng, Xiaoqing; Mu, Cuicui

    2017-09-02

    Soil thermal and hydraulic regimes are critical factors influencing terrestrial processes in cold regions. Collection of field data from frozen ground has occurred at point scales, but limited data exist that characterize changes of soil thermal and hydraulic regimes at the scale of the whole Heihe River Basin. This study uses a long-term regional climate model coupled with land surface model to investigate the soil thermal and hydraulic regime changes at a large spatial scale. It also explores potential factors, including the climate and non-climate factors. Results show that there is significant variability in mean annual air temperature (MAAT) of about 0.47 °C/decade during 1980-2013. A time series of area-averaged mean annual soil temperature (MAST) over the whole Heihe River Basin shows a significant increase between 0.25 and 0.36 °C/decade during 1984-2013, with a net change of 0.9 °C. A trend of increasing wetness is found in soil moisture. Frozen days (FD) decreased significantly both in seasonally frozen ground (SFG) regions and permafrost regions, with a net change between 7 and 13 days during 1984-2013. Freezing index (FI) had a positive effect on FD, while thawing index (TI), MAAT, precipitation, and normalized difference vegetation index (NDVI) had a negative effect. These results are important to understand dynamic mechanisms of soil freeze/thaw cycles.

  19. Multi-institutional MicroCT image comparison of image-guided small animal irradiators

    Science.gov (United States)

    Johnstone, Chris D.; Lindsay, Patricia; E Graves, Edward; Wong, Eugene; Perez, Jessica R.; Poirier, Yannick; Ben-Bouchta, Youssef; Kanesalingam, Thilakshan; Chen, Haijian; E Rubinstein, Ashley; Sheng, Ke; Bazalova-Carter, Magdalena

    2017-07-01

    To recommend imaging protocols and establish tolerance levels for microCT image quality assurance (QA) performed on conformal image-guided small animal irradiators. A fully automated QA software SAPA (small animal phantom analyzer) for image analysis of the commercial Shelley micro-CT MCTP 610 phantom was developed, in which quantitative analyses of CT number linearity, signal-to-noise ratio (SNR), uniformity and noise, geometric accuracy, spatial resolution by means of modulation transfer function (MTF), and CT contrast were performed. Phantom microCT scans from eleven institutions acquired with four image-guided small animal irradiator units (including the commercial PXi X-RAD SmART and Xstrahl SARRP systems) with varying parameters used for routine small animal imaging were analyzed. Multi-institutional data sets were compared using SAPA, based on which tolerance levels for each QA test were established and imaging protocols for QA were recommended. By analyzing microCT data from 11 institutions, we established image QA tolerance levels for all image quality tests. CT number linearity set to R 2  >  0.990 was acceptable in microCT data acquired at all but three institutions. Acceptable SNR  >  36 and noise levels  1.5 lp mm-1 for MTF  =  0.2) was obtained at all but four institutions due to their large image voxel size used (>0.275 mm). Ten of the eleven institutions passed the set QA tolerance for geometric accuracy (2000 HU for 30 mgI ml-1). We recommend performing imaging QA with 70 kVp, 1.5 mA, 120 s imaging time, 0.20 mm voxel size, and a frame rate of 5 fps for the PXi X-RAD SmART. For the Xstrahl SARRP, we recommend using 60 kVp, 1.0 mA, 240 s imaging time, 0.20 mm voxel size, and 6 fps. These imaging protocols should result in high quality images that pass the set tolerance levels on all systems. Average SAPA computation time for complete QA analysis for a 0.20 mm voxel, 400 slice Shelley phantom microCT data set

  20. Evaluation of branched GDGTs and leaf wax n-alkane δ2H as (paleo) environmental proxies in East Africa

    Science.gov (United States)

    Coffinet, Sarah; Huguet, Arnaud; Pedentchouk, Nikolai; Bergonzini, Laurent; Omuombo, Christine; Williamson, David; Anquetil, Christelle; Jones, Martin; Majule, Amos; Wagner, Thomas; Derenne, Sylvie

    2017-02-01

    The role of mountain evolution on local climate is poorly understood and potentially underestimated in climate models. One prominent example is East Africa, which underwent major geodynamic changes with the onset of the East African Rift System (EARS) more than 250 Myr ago. This study explores, at the regional East African scale, a molecular approach for terrestrially-based paleo-climatic reconstructions that takes into account both changes in temperature and in altitude, potentially leading to an improved concept in paleo-climatic reconstructions. Using surface soils collected along pronounced altitudinal gradients in Mt. Rungwe (n = 40; Southwest Tanzania) and Mt. Kenya (n = 20; Central Kenya), we investigate the combination of 2 terrestrial proxies, leaf wax n-alkane δ2H (δ2Hwax) and branched glycerol dialkyl glycerol tetraether (br GDGT) membrane lipids, as (paleo) elevation and (paleo) temperature proxies, respectively. At the mountain scale, a weak link between δ2Hwax and altitude (R2 = 0.33) is observed at Mt. Kenya, but no relationship is observed at Mt. Rungwe. It is likely that additional parameters, such as decreasing relative humidity (RH) or vegetation changes with altitude, are outcompeting the expected 2H-depletion trend along Mt. Rungwe. In contrast, br GDGT-derived absolute mean annual air temperature (MAAT) and temperature lapse rate (0.65 °C/100 m) for both mountains are in good agreement with direct field measurements, further supporting the robustness of this molecular proxy for (paleo) temperature reconstructions. At the regional scale, estimated and observed δ2H data in precipitation along 3 mountains in East Africa (Mts. Rungwe, Kenya and Kilimanjaro) highlight a strong spatial heterogeneity, preventing the establishment of a regional based calibration of δ2Hwax for paeloaltitudinal reconstructions. Different from that, an improved regional soil calibration is developed between br GDGT distribution and MAAT by combining the data from

  1. Provenance of tetraether membrane lipids in a large temperate lake (Loch Lomond, UK: implications for GDGT-based palaeothermometry

    Directory of Open Access Journals (Sweden)

    L. K. Buckles

    2014-03-01

    Full Text Available The application of glycerol dialkyl glycerol tetraether (GDGT-based palaeoenvironmental proxies, such as the BIT index, TEX86 and the MBT/CBT palaeothermometer, has lately been expanded to lacustrine sediments. Given recent research identifying the production of branched, bacterial GDGTs (brGDGTs within lakes, it is necessary to ascertain the effect of this lacustrine production on GDGT-based proxies. This study profiles a temperate, monomictic lake (Loch Lomond, UK, analysing labile intact polar GDGT lipids (IPLs and resilient core GDGT lipids (CLs in catchment soils, small tributary rivers, lake water and lake sediments. Loch Lomond consists of two basins bisected by the Highland Boundary Fault, resulting in a mesotrophic to oligotrophic gradient from south to north. The north basin is fjord-like, while the south basin is shallow with a lowland catchment. Besides abundant influxes of allochthonous soil and peat-derived (CL brGDGTs, brGDGTs are produced in a variety of settings in Loch Lomond. Rather than integrating a scattered soil signal, there is some evidence that small rivers may contribute to the brGDGT pool through addition of brGDGTs produced in situ in these streams. 300 days of settling particles and water column profiles of suspended particulate matter (SPM; March and September 2011 reveal brGDGT production throughout the water column, with (IPL and CL brGDGT distributions varying by basin. In lake sediments, in situ brGDGT production affects the distributions of sedimentary brGDGTs despite high soil and peat-derived organic matter influxes from the catchment. MBT/CBT-derived mean annual air temperature (MAAT estimates from soil, river and lake sediments vary widely. A strong bias towards higher MAATs in the south and lower MAATs in the north basin further complicates the application of the proxy. These results emphasise that caution must be exercised when applying the MBT/CBT palaeothermometer to individual lakes in which the use

  2. Bacterial GDGTs in Holocene sediments and catchment soils of a high Alpine lake: application of the MBT/CBT-paleothermometer

    Directory of Open Access Journals (Sweden)

    H. Niemann

    2012-05-01

    Full Text Available A novel proxy for continental mean annual air temperature (MAAT and soil pH, the MBT/CBT-paleothermometer, is based on the temperature (T and pH-dependent distribution of specific bacterial membrane lipids (branched glycerol dialkyl glycerol tetraethers – GDGTs in soil organic matter. Here, we tested the applicability of the MBT/CBT-paleothermometer to sediments from Lake Cadagno, a high Alpine lake in southern Switzerland with a small catchment of 2.4 km2. We analysed the distribution of bacterial GDGTs in catchment soils and in a radiocarbon-dated sediment core from the centre of the lake, covering the past 11 000 yr. The distribution of bacterial GDGTs in the catchment soils is very similar to that in the lake's surface sediments, indicating a common origin of the lipids. Consequently, their transfer from the soils into the sediment record seems undisturbed, probably without any significant alteration of their distribution through in situ production in the lake itself or early diagenesis of branched GDGTs. The MBT/CBT-inferred MAAT estimates from soils and surface sediments are in good agreement with instrumental values for the Lake Cadagno region (~0.5 °C. Moreover, downcore MBT/CBT-derived MAAT estimates match in timing and magnitude other proxy-based T reconstructions from nearby locations for the last two millennia. Major climate anomalies recorded by the MBT/CBT-paleothermometer are, for instance, the Little Ice Age (~14th to 19th century and the Medieval Warm Period (MWP, ~9th to 14th century. Together, our observations indicate the quantitative applicability of the MBT/CBT-paleothermometer to Lake Cadagno sediments. In addition to the MWP, our lacustrine paleo T record indicates Holocene warm phases at about 3, 5, 7 and 11 kyr before present, which agrees in timing with other records from both the Alps and the sub-polar North-East Atlantic Ocean. The good temporal match of the warm periods determined

  3. A statistical approach to modelling permafrost distribution in the European Alps or similar mountain ranges

    Directory of Open Access Journals (Sweden)

    L. Boeckli

    2012-01-01

    Full Text Available Estimates of permafrost distribution in mountain regions are important for the assessment of climate change effects on natural and human systems. In order to make permafrost analyses and the establishment of guidelines for e.g. construction or hazard assessment comparable and compatible between regions, one consistent and traceable model for the entire Alpine domain is required. For the calibration of statistical models, the scarcity of suitable and reliable information about the presence or absence of permafrost makes the use of large areas attractive due to the larger data base available.

    We present a strategy and method for modelling permafrost distribution of entire mountain regions and provide the results of statistical analyses and model calibration for the European Alps. Starting from an integrated model framework, two statistical sub-models are developed, one for debris-covered areas (debris model and one for steep bedrock (rock model. They are calibrated using rock glacier inventories and rock surface temperatures. To support the later generalization to surface characteristics other than those available for calibration, so-called offset terms have been introduced into the model that allow doing this in a transparent and traceable manner.

    For the debris model a generalized linear mixed-effect model (GLMM is used to predict the probability of a rock glacier being intact as opposed to relict. It is based on the explanatory variables mean annual air temperature (MAAT, potential incoming solar radiation (PISR and the mean annual sum of precipitation (PRECIP, and achieves an excellent discrimination (area under the receiver-operating characteristic, AUROC = 0.91. Surprisingly, the probability of a rock glacier being intact is positively associated with increasing PRECIP for given MAAT and PISR conditions. The rock model is based on a linear regression and was calibrated with mean annual rock surface temperatures (MARST. The

  4. [Characterization of the intestinal digestive glycosidases in plankton- and benthos-feeding species of the fish genus Ballerus (Cyprinidae)].

    Science.gov (United States)

    Golovanova, I L; Filippov, A A; Bolotovskiĭ, A A; Levin, B A

    2015-01-01

    The activity of hydrolases (maltase, saccharase, amylolytic activity) in the intestinal mucosa of the plankton-feeding zope Ballerus ballerus and the benthos-feeding white-eye bream Ballerus sapa was investigated. The temperature characteristics of maltase hydrolysis (T(opt) and E(act)) are similar in both species. The lower K(m) of maltase hydrolysis in the white-eye bream reflects a higher enzyme/substrate affinity and indicates a more effective carbohydrate hydrolysis in the benthos-versus plankton-feeding species. The glycosidase activity in the white-eye bream is twice as high as in the zope. This may be due not only to different feeding spectra and biochemical food contents but also to the differences in thyroid status of species under consideration.

  5. Anti-galectin-1 autoantibodies in human Trypanosoma cruzi infection: differential expression of this beta-galactoside-binding protein in cardiac Chagas' disease.

    Science.gov (United States)

    Giordanengo, L; Gea, S; Barbieri, G; Rabinovich, G A

    2001-05-01

    The pathogenesis of Chagas' disease has been subject of active research and still remains to be ascertained. Galectin-1 (Gal-1), a member of a conserved family of animal beta-galactoside-binding proteins, localized in human heart tissue, has been suggested to play key roles in immunological and inflammatory processes. In the present study we demonstrated the occurrence of anti-Gal-1 autoAb in sera from patients in the acute and chronic stages of Chagas' disease (ACD and CCD) by means of ELISA and Western blot analysis. We found a marked increase in the level and frequency of Ig E anti-Gal-1 antibodies in sera from patients with ACD, but a low frequency of Ig M anti-Gal-1 immunoreactivity. Moreover, Ig G immunoreactivity to this beta-galactoside-binding protein was found to be correlated with the severity of cardiac damage in CCD, but was absent in nonrelated cardiomyopathies. We could not detect immunoreactivity with Trypanosoma cruzi antigens using a polyclonal antibody raised to human Gal-1 and no hemagglutinating activity could be specifically eluted from a lactosyl-agarose matrix from parasite lysates. Moreover, despite sequence homology between Gal-1 and shed acute phase antigen (SAPA) of T. cruzi, anti-Gal-1 antibodies eluted from human sera failed to cross-react with SAPA. In an attempt to explore whether Gal-1 immunoreactivity was originated from endogenous human Gal-1, we finally investigated its expression levels in cardiac tissue (the main target of Chagas' disease). This protein was found to be markedly upregulated in cardiac tissue from patients with severe CCD, compared to cardiac tissue from normal individuals.

  6. Anti-galectin-1 autoantibodies in human Trypanosoma cruzi infection: differential expression of this β-galactoside-binding protein in cardiac Chagas' disease

    Science.gov (United States)

    Giordanengo, L; Gea, S; Barbieri, G; Rabinovich, G A

    2001-01-01

    The pathogenesis of Chagas' disease has been subject of active research and still remains to be ascertained. Galectin-1 (Gal-1), a member of a conserved family of animal β-galactoside-binding proteins, localized in human heart tissue, has been suggested to play key roles in immunological and inflammatory processes. In the present study we demonstrated the occurrence of anti-Gal-1 autoAb in sera from patients in the acute and chronic stages of Chagas' disease (ACD and CCD) by means of ELISA and Western blot analysis. We found a marked increase in the level and frequency of Ig E anti-Gal-1 antibodies in sera from patients with ACD, but a low frequency of Ig M anti-Gal-1 immunoreactivity. Moreover, Ig G immunoreactivity to this β-galactoside-binding protein was found to be correlated with the severity of cardiac damage in CCD, but was absent in nonrelated cardiomyopathies. We could not detect immunoreactivity with Trypanosoma cruzi antigens using a polyclonal antibody raised to human Gal-1 and no hemagglutinating activity could be specifically eluted from a lactosyl-agarose matrix from parasite lysates. Moreover, despite sequence homology between Gal-1 and shed acute phase antigen (SAPA) of T. cruzi, anti-Gal-1 antibodies eluted from human sera failed to cross-react with SAPA. In an attempt to explore whether Gal-1 immunoreactivity was originated from endogenous human Gal-1, we finally investigated its expression levels in cardiac tissue (the main target of Chagas' disease). This protein was found to be markedly upregulated in cardiac tissue from patients with severe CCD, compared to cardiac tissue from normal individuals. PMID:11422204

  7. Personality disorder and self-rated health: a population-based cross-sectional survey.

    Science.gov (United States)

    Fok, Marcella; Hotopf, Matthew; Stewart, Robert; Hatch, Stephani; Hayes, Richard; Moran, Paul

    2014-06-01

    Little is known about the impact of personality disorder (PD) on the health of people living in the community. The authors set out to examine the association between PD and general health, using a cross-sectional survey of a representative community sample in London, UK. A total of 1,698 adults aged 16 years or over from 1,075 randomly selected households were recruited and interviewed face-to-face by trained interviewers. Using multivariable logistic regression, the authors examined the cross-sectional association between PD screen status, as assessed by the Standardised Assessment of Personality-Abbreviated Scale (SAPAS), and self-rated health, adjusting for demographic and health covariates. Of the participants, 14.5% screened positively for PD. A greater proportion of those scoring positively for PD reported poor self-rated health, compared to screen negative participants (41.3% versus 15.0%). This association was reduced, but remained significant, after adjustment for potential confounders (unadjusted odds ratio (OR) = 3.99, 95% CI [2.93, 5.42]; fully adjusted OR = 1.53, 95% CI [1.02, 2.29]. Of note, subthreshold symptoms of PD were significantly associated with poor self-rated health (unadjusted OR per unit SAPAS score increment = 1.53, 95% CI [1.40, 1.67]; fully adjusted OR = 1.19, 95% CI [1.07, 1.33]. Furthermore, people screening positive for PD were more likely to report multiple (three or more) long-standing illnesses. The authors conclude that in the general population, individuals who are at high risk for PD are independently at increased risk of poor general health.

  8. Periglacial processes incorporated into a long-term landscape evolution model

    DEFF Research Database (Denmark)

    Andersen, Jane Lund; Egholm, D.L.; Knudsen, Mads Faurschou

    relating frost-cracking intensity to the mean annual air temperature (MAAT). The model integrates temperature variations in the subsurface following an annually oscillating surface temperature. Hales and Roering (2007) assumed that frost-cracking intensity is a simple function of the temperature gradient......Little is known about the long-term influence of periglacial processes on landscape evolution in cold areas, even though the efficiency of frost cracking on the breakdown of rocks has been documented by observations and experiments. Cold-room laboratory experiments show that a continuous water...... by their model and the elevation of scree deposits in the Southern Alps, New Zealand. This result suggests a link between frost-cracking efficiency and long-term landscape evolution and thus merits further investigations. Anderson et al. (2012) expanded this early model by including the effects of latent heat...

  9. Reduction in Fabrication Costs of Gas Diffusion Layers

    Energy Technology Data Exchange (ETDEWEB)

    Jason Morgan; Donald Connors; Michael Hickner

    2012-07-10

    Ballard Material Products (BMP) performed a pre-design technical and cost analysis of state of the art production technologies feasible for high volume GDL manufacturing. Based upon criteria that also included environmental health and safety, customer quality requirements, and future needs, BMP selected technologies that can be integrated into its current manufacturing process. These selections included Many-At-A-Time (MAAT) coating and continuous mixing technologies, as well as various on-line process control tools. These processes have allowed BMP to produce high performance GDLs at lower cost for near-term markets, as well as to define the inputs needed to develop a conceptual Greenfield facility to meet the cost targets for automotive volumes of 500,000 vehicles per year.

  10. Numerical Studies for Insulation Application to Embankment of Qinghai-Tibetan Railway%保温材料在青藏铁路路基工程中应用的数值分析

    Institute of Scientific and Technical Information of China (English)

    温智; 盛煜; 马巍; 齐吉琳; 吴基春

    2004-01-01

    In many cases, preventing permafrost from further thaw due to human activities might be the first choice for embankment design in permafrost regions. 2-D finite element analysis was conducted in this paper, in which phase change was taken into consideration to simulate the thermal regime of the Qinghai-Tibetan Railway with Expandable Polystyrene (EPS). Based on the predicted maximum thaw depth in the following 50 year, the best position for insulation was presented and the relationship between the thickness of insulation and the height of embankment was analyzed. Besides, the applicable range of insulation in embankment engineering of the Qinghai-Tibetan Railway in terms of Mean Annual Air Temperature (MAAT) was suggested and the influence of geothermal field of permafrost on the applicable range of the insulation was discussed.

  11. Two—parameter—dependent Drag Coefficient Over Sea Surface by Turbulent Modeling

    Institute of Scientific and Technical Information of China (English)

    JiachunLI; ZifanZHANG

    1999-01-01

    A new model accounting for both turbulence and sea state effects has been proposed in the current paper to describe momentum exchange through air-sea interface.While long wave components mainly change air flow profile,short wave components exert their influences on the momentum exchange via turbulent stress,which leads to the growth of drag coefficients by a factor of two in young wave age circumstances,As a typical case study,we have considered neutral ABL over a representative regular wave with roughness due to short capillary wves riding over it.The results by the pressent model are in reasonable agreement with Maat's analysis numerically fitted by HEXMAX data and Janssen's results.Two parameter dependence of drag coefficient can resolve the existing discrepency between theory and observations.

  12. The Development of the Sacred Landscape of Saqqara in the Old Kingdom

    Science.gov (United States)

    Magli, Giulio

    2015-05-01

    Saqqara is one of the most important Necropolis in Egypt. In the course of the third millennium BC many Pharaohs choose Saqqara for their tombs. As a consequence the landscape constantly grew with the addition of new monuments, from the mastaba tombs of the first dynasty to the last pyramid of the Old Kingdom, that of Pepi II. The monuments were constructed respecting a series of topographical constraints which are not due to the morphology of the area but rather reflect symbolic - dynastic or astronomical - motivations. The analysis of these connections gives a better understanding of the choices made by the kings' architects in order to keep Maat - order - in the development of the site. Further, the way in which the sacred landscape came to be structured at the end of the Old Kingdom allows us to formulate a proposal for the possible location of the unique pyramid of the sixth dynasty which is still to be found: that of Userkare.

  13. De la boule de neige sale au canard en caoutchouc noir, 67P/ Churyumov Gerasimenko, From the dirty snowball to the rubber black duck, 67P/ Churyumov Gerasimenko

    Science.gov (United States)

    Borg, Janet

    2016-12-01

    Rosetta has ended its mission on 30 September 2016 with a controlled impact in the Ma'at region on the small lobe of comet 67P/ Churyumov Gerasimenko. Since its arrival in the vicinity of the comet in august 2014, Rosetta has spent more than two years living with the comet, investigating its nucleus and its environment. It has witnessed how a comet changes as it approached perihelia and after, returned to the outer solar system. This paper is a summary of the main results obtained from the returned data that give a completely new image of what is a comet. In the future, information obtained from the analysis of more data will of course lead to more progress in a better understanding of comets, and more generally of the formation of the solar system and even of the emergence of live on Earth.

  14. Electromyographic activity of the jaw muscles and mandibular kinematics in young adults with theoretically ideal dental occlusion: Reference values.

    Science.gov (United States)

    Campillo, B; Martín, C; Palma, J-C; Fuentes, A-D; Alarcón, J-A

    2017-05-01

    A necessary step to use neuromuscular analysis as diagnostic tool is to establish normal reference values for the physiological range in a healthy population. Surface electromyographic (sEMG) activity of the jaw muscles and mandibular kinematics were measured in young adults with theoretically ideal dental occlusion to determine normal reference values during different tasks. Differences between the sexes were evaluated. Forty young adults (20 men, 20 women; mean age 22.8 ± 3.9 years) with theoretically ideal dental occlusion were selected using very restrictive criteria. sEMG activity of the anterior temporalis (AT), posterior temporalis, masseter (MA), and suprahyoid muscles were evaluated in the rest position and during swallowing, mastication, and clenching. Mandibular kinematics in the rest position and during maximum excursions were assessed. Asymmetry, activity, and torque indices and MA/AT ratios were calculated. For all muscles, sEMG values were 1.01-3.57 µV at rest, 3.50-10.85 µV during swallowing, and 41.04-86.59 µV during mastication. During clenching, values were 230.08-243.55 µV for the AT and MA muscles. Mean total asymmetry, activity, and torque indices at rest were 20.34 %, -15.04 %, and 19.02 %, respectively; during clenching, these values were 6.14 %, -2.62 %, and 4.46 %. MA/AT ratios were near 1. Kinematic measurements during lateral excursion, protrusive and maximum opening were 7.54, 8.44, and 37.38 mm respectively; lateral mandibular shift was 1.41 mm; free way and lateral displacement at rest were 1.40 and 0.26 mm. Right MA activity during mastication and clenching was higher in men than women. Reference values for sEMG activity and mandibular kinematics were determined. Some muscular asymmetry and torque were observed.

  15. Spatial distribution and characteristics of permafrost in Hurd Peninsula, Livingston Island, Maritime Antarctic

    Science.gov (United States)

    Vieira, G.; Ramos, M.; Trindade, A.; Gruber, S.; Hauck, C.; Mora, C.; Batista, V.; Neves, M.; Pimpirev, C.; Kenderova, R.

    2009-04-01

    The Antarctic Peninsula is one of Earth's regions experiencing a faster increase on temperatures, with Mean Annual Air Temperatures (MAAT) rising ca. 2.5 °C in the last 50 years. The northerly location of the Antarctic Peninsula in respect to the Antarctic and its oceanic setting originate a milder and moister climate than in the Antarctic continent. The Northern Antarctic Peninsula is roughly located between the isotherms of MAAT of -1 °C to -8 °C at sea-level and therefore the northern tip and especially the South Shetlands are close to the limits of permafrost occurrence. If the observed warming trend is to continue in the near future, the region might suffer widespread permafrost degradation. Research on the permafrost environment of Hurd Peninsula has been taking place with systematical measurements by our group since January 2000 and currently we are able to provide a good overview of the spatial distribution and characteristics of permafrost terrain in Hurd Peninsula. Our research is based on shallow boreholes (Collado Ramos (115m). In 2006 Electrical Tomography Resistivity and refraction seismic profiles have been performed, providing us with a good overview of the general conditions of the permafrost terrain in the area. Air temperatures are measured at different sites accounting for altitude since a few years and during 3 summer campaigns the radiation balance was monitored continuously at two sites. Detailed geomorphological mapping of periglacial features has been conducted at a scale 1:5,000 providing important information about the geomorphological dynamics. Using the data gathered since 2000 it is now possible to present the general characteristics of the permafrost distribution in Hurd Peninsula as a first step towards a more comprehensive approach that is now starting that involves empirico-statistical modeling, remote sensing, as well as downscaling of mesoscale climate data.

  16. Adsorption of methyl orange and salicylic acid on a nano-transition metal composite: Kinetics, thermodynamic and electrochemical studies.

    Science.gov (United States)

    Arshadi, M; Mousavinia, F; Amiri, M J; Faraji, A R

    2016-12-01

    In this work synthesis of Mn-nanoparticles (MnNPs) supported on the Schiff base modified nano-sized SiO2Al2O3 mixed-oxides (Si/Al) and its implementation as an adsorbent for the removal of organic pollutions such as methyl orange (MO) and salicylic acid (SA) was investigated. Si/Al were functionalized by grafting Schiff base ligand and in the next step, MnNPs were prepared over the modified nano sol-gel Si/Al. Structures and adsorption characteristics of the obtained organometallic-modified SiO2/Al2O3 mixed oxide were studied by several methods such as elemental analysis, diffuse reflectance UV-vis spectroscopy, FT-IR spectroscopy, nitrogen adsorption/desorption, scanning electron microscope (SEM), transmission electron microscope (TEM), energy dispersive X-ray (EDX), inductively coupled plasma (ICP-AES), Electron Paramagnetic Resonance (EPR), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). EPR data of the immobilized manganese ions resulted that the transition state of active sites in the nano-adsorbent are in the form of Mn(II) ions at the surface. The adsorption properties of heterogeneous Mn(II) ions showed that this nano-adsorbent has very good potential to remove MO and SA ions from aqueous solution. The removal efficiency of the SAPAS@MnNPs towards MO reached out to 89.3 and 29.1% and for SA approached to 54.6 and 18.9% at 150 and 500mg/dm(3) initial organic pollution concentrations, respectively. To investigate the adsorption kinetic of Mn(II) ions onto the nano-sized support, pseudo first and pseudo second order kinetics, and the Freundlich, Langmuir and Langmuir-Freundlich isotherm models have also been applied to the equilibrium adsorption data. The contact time to obtain equilibrium for maximum adsorption capacity was 45min. The adsorption process was spontaneous and endothermic in nature and it was well explained with pseudo-second-order kinetic model. No remarkable loss of removal capacity even after 8th times regeneration

  17. Soil thermal regime on ice-free areas in Livingston Island and James Ross Island, Antarctic Peninsula region

    Science.gov (United States)

    Hrbáček, Filip; Oliva, Marc; Láska, Kamil; Ruiz-Fernández, Jesús; Ángel de Pablo, Miguel; Vieira, Gonçalo; Ramos, Miguel; Nývlt, Daniel

    2016-04-01

    Permafrost and active layer are considered prominent components of the Cryosphere, which react very sensitively to small climate variations. The Antarctic Peninsula (AP) region is considered as one of the fastest warming regions on Earth, where mean annual air temperature locally increased more than 2.5°C over the last 60 years. Significant climate differences are found between the eastern and western sides of the AP. While mean annual air temperatures (MAAT) oscillate around -1 to -2 °C and precipitation reach 800 mm w.e. year-1 in the western AP, the MAAT in the eastern AP are below -6 °C and precipitation does not exceed 500 mm. These differences determine different permafrost thickness and spatial distribution in these two regions, as well as diverse patterns of active layer dynamics. With the purpose to better understand the factors controlling the soil thermal regime in maritime permafrost environments, we examine data from 2014 acquired from several sites in Livingston Island (western AP) and James Ross Island (eastern AP). The study sites show similar characteristics in terms of topography (slope Ross Island ranged from -7.0 to -7.9 °C. Mean soil temperature at 5 cm depth was slightly higher than air temperature in both areas: -0.7 to -1.3 °C in Livingston Island and -6.2 to -6.3 °C in James Ross Island; the same occurred for soil temperature at 75 cm: -0.4 to -0.7 °C in Livingston Island and -6.0 to -6.6 °C James Ross Island. Significantly lower values of mean daily amplitude of soil temperature at 5 cm depth and the freezing n-factor values observed during the freezing season on Livingston Island suggest a pronounced insulating effect of snow cover in this area in comparison to James Ross Island. The mean daily amplitude of soil temperature at 5 cm ranged from 0.9 to 1.7 °C in Livingston Island, while it reached 3.0 to 4.0 °C in James Ross Island. The freezing n-factor reached 0.33 and 0.63 on Livingston Island, while 0.88 and 0.98 were

  18. Identification of a novel lipid biomarker in lake sediments: Implications for the aquatic production of branched GDGTs

    Science.gov (United States)

    Weber, Yuki; De Jonge, Cindy; Rijpstra, W. Irene C.; Hopmans, Ellen C.; Stadnitskaia, Alina; Schubert, Carsten J.; Lehmann, Moritz F.; Sinninghe Damsté, Jaap S.; Niemann, Helge

    2014-05-01

    Branched dialkyl glycerol tetraethers (brGDGTs) are bacterial membrane lipids that occur ubiquitously in soils worldwide. Their relative abundances (which form the MBT and CBT indices) correlate with mean annual air temperature (MAAT) and pH, making them potential proxies for paleoenvironmental reconstructions in sedimentary archives with organic matter input of from terrestrial environments. In lake sediments, however, brGDGT distributions mostly relate differently to MAAT compared to soils. A likely cause for this discrepancy is in situ production of brGDGTs within the lake water column and/or -sediments by microorganisms possessing a membrane physiology that is different from soil bacteria. Until to date, existing analytical methods did not allow the distinction between soil-and lake-derived brGDGTs, complicating paleoclimate reconstructions in lacustrine settings. In order to decipher differences in the structure and the relative distribution of brGDGTs in lake deposits versus soils, we analysed samples from 35 Swiss alpine lakes and their catchments using an improved HPLC protocol. Our data revealed a novel isomer of the hexamethylated, non-cyclic brGDGT, which was previously co-eluting with the recently described 5- and 6-methyl isomers. About half of the 35 investigated lakes contained this compound where it accounted for 1 - 11 % of total brGDGTs. We were able to isolate the previously unknown isomer by multi-step preparative HPLC. The structure of the molecule was assessed by determining the identity of its alkyl chains by ether cleavage with HI and subsequent analysis with gas chromatography quadrupole mass spectrometry (GC-MS). In addition, the carbon isotopic composition of the fragments was determined to trace their biological source. In contrast to lake sediments, soil samples analysed from the watersheds of the studied lakes did not contain the newly discovered GDGT, providing evidence for in situ production in aquatic systems. This novel isomer is

  19. The presence of rapidly degrading permafrost plateaus in southcentral Alaska

    Science.gov (United States)

    Jones, Benjamin M.; Baughman, Carson; Romanovsky, V.adimir E; Parsekian, Andrew D.; Babcock, Esther; Jones, Miriam C.; Grosse, Guido; Berg, Edward E

    2016-01-01

    Permafrost presence is determined by a complex interaction of climatic, topographic, and ecological conditions operating over long time scales. In particular, vegetation and organic layer characteristics may act to protect permafrost in regions with a mean annual air temperature (MAAT) above 0°C. In this study, we document the presence of residual permafrost plateaus on the western Kenai Peninsula lowlands of southcentral Alaska, a region with a MAAT of 1.5 ± 1°C (1981 to 2010). Continuous ground temperature measurements between 16 September 2012 and 15 September 2015, using calibrated thermistor strings, documented the presence of warm permafrost (−0.04 to −0.08°C). Field measurements (probing) on several plateau features during the fall of 2015 showed that the depth to the permafrost table averaged 1.48 m but was as shallow as 0.53 m. Late winter surveys (drilling, coring, and GPR) in 2016 showed that the average seasonally frozen ground thickness was 0.45 m, overlying a talik above the permafrost table. Measured permafrost thickness ranged from 0.33 to >6.90 m. Manual interpretation of historic aerial photography acquired in 1950 indicates that residual permafrost plateaus covered 920 ha as mapped across portions of four wetland complexes encompassing 4810 ha. However, between 1950 and ca. 2010, permafrost plateau extent decreased by 60%, with lateral feature degradation accounting for 85% of the reduction in area. Permafrost loss on the Kenai Peninsula is likely associated with a warming climate, wildfires that remove the protective forest and organic layer cover, groundwater flow at depth, and lateral heat transfer from wetland surface waters in the summer. Better understanding the resilience and vulnerability of ecosystem-protected permafrost is critical for mapping and predicting future permafrost extent and degradation across all permafrost regions that are currently warming. Further work should focus on reconstructing permafrost history in

  20. Willem II of Floris de Voogd? Vragen rond een grafmonument en een skelet in de Koorkerk te Middelburg

    Directory of Open Access Journals (Sweden)

    Peter Henderikx

    2015-12-01

    Full Text Available William II or Florence the Guardian?: Questions about a Tomb and a Skeleton in the Abbey Church at MiddelburgBoth William II, Count of Holland and Zeeland and King of the Holy Roman Empire (†1256, re-interred 1282 and his brother Florence the Guardian (†1258 are buried in the Norbertine abbey church in Middelburg. In 1817 a skeleton was found in a bricked up niche, along with the remains of a tombstone on which was carved a knightly figure whose shield bears the coat of arms of Holland. Based on the results of an examination of the bones by George J.R. Maat and his team (Leiden University Medical Centre, Henderikx takes it that the skeleton could be either that of the King of the Holy Roman Empire or of Florence the Guardian. Considering that the skeleton, burial space and tombstone formed a coherent whole, and the high-relief on the tombstone almost certainly does not refer to the King of Rome but to his brother, Henderikx concludes that the skeleton must be the  earthly remains of Florence the Guardian.Roomskoning Willem II, graaf van Holland en Zeeland (†1256, herbegraven 1282 en diens broer Floris de Voogd (†1258 zijn beiden in de norbertijner abdijkerk in Middelburg begraven. In 1817 werd daar in een dichtgemetselde nis een skelet aangetroffen samen met de resten van een zerk met daarop een gebeeldhouwde ridderfiguur met op diens wapenschild het wapen van Holland. Uitgaande van de resultaten van het onderzoek van het botmateriaal door George J.R. Maat cum suis (Leids Universitair Medisch Centrum stelt Henderikx vast dat het skelet afkomstig kan zijn van zowel de Roomskoning als van Floris de Voogd. Aangezien skelet, grafruimte en zerk steeds één samenhangend geheel hebben gevormd en het beeldhouwwerk op de zerk zo goed als zeker niet naar de Roomskoning maar naar diens broer verwijst, komt Henderikx tot de conclusie dat het skelet het stoffelijk overschot moet zijn van Floris de Voogd.

  1. DSpace 跨機構虛擬儲存庫之可行性研究 The Feasibility Study of DSpace towards a Virtual Cross-Institutional Repository

    Directory of Open Access Journals (Sweden)

    Ya-Ning Chen

    2004-12-01

    Full Text Available DSpace已被學術機構廣泛使用,以達到資訊之管理與再利用的工具軟體。本文選擇數位典藏國家型科技計畫後設資料工作組(Metadata Architecture and Application Team, MAAT)網站為研究案例,來檢驗 DSpace系統是否適用於跨組織虛擬數位典藏庫的可行性議題。MAAT網站是一個靜態網站,其中包含全台灣各個機構不同的數位圖書館計畫所產生的大量文件。本研究歸納出,若DSpace的某些功能能提供更有彈性的客製化,例如Community與Collection的階層架構與查詢,以及關聯建立與鏈結搜尋、詞彙控制、索引重建與中文查詢等,DSpace不只可以作為單一個機構內所使用的數位典藏庫,也適合當作跨組織虛擬典藏庫的功能來使用。DSpace is a software tool that is often used as a digital repository for academic institutions to achieve management and reuse of information. This paper uses the Metadata Architecture and Application Team (MAAT website in a case study to examine the feasibility issue of whether DSpace is suitable as a virtual digital repository for inter-institutional use. The MAAT website is arranged in a static manner and comprises a number of documents for various digital library projects conducted by different institutions in Taiwan. The study concludes that DSpace is not only a digital repository suitable for single-institutional use, but also a virtual digital repository suitable for cross-institutional use; that is, if DSpace offered more flexible customizations for functions, such as hierarchical level and query of community and collection, association and linkage search, vocabulary control, re-index, and Chinese query.

  2. Presence of rapidly degrading permafrost plateaus in south-central Alaska

    Science.gov (United States)

    Jones, Benjamin M.; Baughman, Carson A.; Romanovsky, Vladimir E.; Parsekian, Andrew D.; Babcock, Esther L.; Stephani, Eva; Jones, Miriam C.; Grosse, Guido; Berg, Edward E.

    2016-11-01

    Permafrost presence is determined by a complex interaction of climatic, topographic, and ecological conditions operating over long time scales. In particular, vegetation and organic layer characteristics may act to protect permafrost in regions with a mean annual air temperature (MAAT) above 0 °C. In this study, we document the presence of residual permafrost plateaus in the western Kenai Peninsula lowlands of south-central Alaska, a region with a MAAT of 1.5 ± 1 °C (1981-2010). Continuous ground temperature measurements between 16 September 2012 and 15 September 2015, using calibrated thermistor strings, documented the presence of warm permafrost (-0.04 to -0.08 °C). Field measurements (probing) on several plateau features during the fall of 2015 showed that the depth to the permafrost table averaged 1.48 m but at some locations was as shallow as 0.53 m. Late winter surveys (augering, coring, and GPR) in 2016 showed that the average seasonally frozen ground thickness was 0.45 m, overlying a talik above the permafrost table. Measured permafrost thickness ranged from 0.33 to > 6.90 m. Manual interpretation of historic aerial photography acquired in 1950 indicates that residual permafrost plateaus covered 920 ha as mapped across portions of four wetland complexes encompassing 4810 ha. However, between 1950 and ca. 2010, permafrost plateau extent decreased by 60.0 %, with lateral feature degradation accounting for 85.0 % of the reduction in area. Permafrost loss on the Kenai Peninsula is likely associated with a warming climate, wildfires that remove the protective forest and organic layer cover, groundwater flow at depth, and lateral heat transfer from wetland surface waters in the summer. Better understanding the resilience and vulnerability of ecosystem-protected permafrost is critical for mapping and predicting future permafrost extent and degradation across all permafrost regions that are currently warming. Further work should focus on reconstructing

  3. Willem II of Floris de Voogd? Vragen rond een grafmonument en een skelet in de Koorkerk te Middelburg

    Directory of Open Access Journals (Sweden)

    Peter Henderikx

    2015-12-01

    Full Text Available William II or Florence the Guardian?: Questions about a Tomb and a Skeleton in the Abbey Church at MiddelburgBoth William II, Count of Holland and Zeeland and King of the Holy Roman Empire (†1256, re-interred 1282 and his brother Florence the Guardian (†1258 are buried in the Norbertine abbey church in Middelburg. In 1817 a skeleton was found in a bricked up niche, along with the remains of a tombstone on which was carved a knightly figure whose shield bears the coat of arms of Holland. Based on the results of an examination of the bones by George J.R. Maat and his team (Leiden University Medical Centre, Henderikx takes it that the skeleton could be either that of the King of the Holy Roman Empire or of Florence the Guardian. Considering that the skeleton, burial space and tombstone formed a coherent whole, and the high-relief on the tombstone almost certainly does not refer to the King of Rome but to his brother, Henderikx concludes that the skeleton must be the  earthly remains of Florence the Guardian.Roomskoning Willem II, graaf van Holland en Zeeland (†1256, herbegraven 1282 en diens broer Floris de Voogd (†1258 zijn beiden in de norbertijner abdijkerk in Middelburg begraven. In 1817 werd daar in een dichtgemetselde nis een skelet aangetroffen samen met de resten van een zerk met daarop een gebeeldhouwde ridderfiguur met op diens wapenschild het wapen van Holland. Uitgaande van de resultaten van het onderzoek van het botmateriaal door George J.R. Maat cum suis (Leids Universitair Medisch Centrum stelt Henderikx vast dat het skelet afkomstig kan zijn van zowel de Roomskoning als van Floris de Voogd. Aangezien skelet, grafruimte en zerk steeds één samenhangend geheel hebben gevormd en het beeldhouwwerk op de zerk zo goed als zeker niet naar de Roomskoning maar naar diens broer verwijst, komt Henderikx tot de conclusie dat het skelet het stoffelijk overschot moet zijn van Floris de Voogd.

  4. Inhibitory Effect of Taurine on Biofilm Formation During Alkane Degradation in Acinetobacter oleivorans DR1.

    Science.gov (United States)

    Eom, Hyo Jung; Park, Woojun

    2017-06-15

    Taurine, 2-aminoethanesulfonate, is known to function as an antioxidant or membrane stabilizer in eukaryotic cells, but its role in bacteria has been poorly characterized. Biofilm formation of Acinetobacter oleivorans DR1 was significantly reduced by taurine only during alkane degradation, suggesting that taurine affects alkane-induced cell surface. Structurally similar compounds harboring an amine group such as hypotaurine or ethylenediamine have a similar effect, which was not observed with sulfonate-containing chemicals such as ethanesulfonic acid, hexanesulfonic acid. Our biochemical assays and physiological tests demonstrate that taurine reduced cell surface hydrophobicity, which resulted in interruption of the interactions between cells and oily substrate surfaces, such that cells utilized alkanes less effectively. Interestingly, taurine-mediated reduction of quorum sensing (QS) signal production and QS-control sapA gene expression indicated that membrane permeability of quorum signals was also interfered by taurine. Composition and biomass of extracellular polymeric saccharides were changed in taurine-amended conditions. Taken together, our data provide evidence that amine-containing taurine can inhibit biofilm formation of DR1 cells during alkane degradation by (i) changing cell surface charge and (ii) reducing membrane hydrophobicity and QS sensing.

  5. Screening for personality disorder in incarcerated adolescent boys

    DEFF Research Database (Denmark)

    Kongerslev, Mickey Toftkjær; Moran, Paul; Bo, Sune

    2012-01-01

    ABSTRACT: BACKGROUND: Personality disorder (PD) is associated with significant functional impairment and an elevated risk of violent and suicidal behaviour. The prevalence of PD in populations of young offenders is likely to be high. However, because the assessment of PD is time-consuming, it is ......ABSTRACT: BACKGROUND: Personality disorder (PD) is associated with significant functional impairment and an elevated risk of violent and suicidal behaviour. The prevalence of PD in populations of young offenders is likely to be high. However, because the assessment of PD is time......-consuming, it is not routinely assessed in this population. A brief screen for the identification of young people who might warrant further detailed assessment of PD could be particularly valuable for clinicians and researchers working in juvenile justice settings. METHOD: We adapted a rapid screen for the identification of PD...... in adults (Standardised Assessment of Personality - Abbreviated Scale; SAPAS) for use with adolescents and then carried out a study of the reliability and validity of the adapted instrument in a sample of 80 adolescent boys in secure institutions. Participants were administered the screen and shortly after...

  6. Screening for personality disorder in incarcerated adolescent boys

    DEFF Research Database (Denmark)

    Simonsen, Erik; Kongerslev, Mickey; Moran, Paul

    2012-01-01

    Background: Personality disorder (PD) is associated with significant functional impairment and an elevated risk of violent and suicidal behaviour. The prevalence of PD in populations of young offenders is likely to be high. However, because the assessment of PD is time-consuming, it is not routin......Background: Personality disorder (PD) is associated with significant functional impairment and an elevated risk of violent and suicidal behaviour. The prevalence of PD in populations of young offenders is likely to be high. However, because the assessment of PD is time......-consuming, it is not routinely assessed in this population. A brief screen for the identification of young people who might warrant further detailed assessment of PD could be particularly valuable for clinicians and researchers working in juvenile justice settings. Method: We adapted a rapid screen for the identification of PD...... in adults (Standardised Assessment of Personality – Abbreviated Scale; SAPAS) for use with adolescents and then carried out a study of the reliability and validity of the adapted instrument in a sample of 80 adolescent boys in secure institutions. Participants were administered the screen and shortly after...

  7. Kappaphycus alvarezii as a source of bioethanol.

    Science.gov (United States)

    Khambhaty, Yasmin; Mody, Kalpana; Gandhi, Mahesh R; Thampy, Sreekumaran; Maiti, Pratyush; Brahmbhatt, Harshad; Eswaran, Karuppanan; Ghosh, Pushpito K

    2012-01-01

    The present study describes production of bio-ethanol from fresh red alga, Kappaphycus alvarezii. It was crushed to expel sap--a biofertilizer--while residual biomass was saccharified at 100 °C in 0.9 N H2SO4. The hydrolysate was repeatedly treated with additional granules to achieve desired reducing sugar concentration. The best yields for saccharification, inclusive of sugar loss in residue, were 26.2% and 30.6% (w/w) at laboratory (250 g) and bench (16 kg) scales, respectively. The hydrolysate was neutralized with lime and the filtrate was desalted by electrodialysis. Saccharomyces cerevisiae (NCIM 3523) was used for ethanol production from this non-traditional bio-resource. Fermentation at laboratory and bench scales converted ca. 80% of reducing sugar into ethanol in near quantitative selectivity. A petrol vehicle was successfully run with E10 gasoline made from the seaweed-based ethanol. Co-production of ethanol and bio-fertilizer from this seaweed may emerge as a promising alternative to land-based bio-ethanol.

  8. USO Y VALOR DEL RECURSO HÍDRICO URBANO. SISTEMA DE AGUA POTABLE EN CULIACÁN, MÉXICO

    Directory of Open Access Journals (Sweden)

    César Domingo Iñíguez Sepúlveda

    2010-01-01

    Full Text Available El propósito de este estudio es construir un sistema para valorar cualitativamente el uso del recurso hídrico como elemento inevitable para el suministro de los servicios de agua potable, alcantarillado y saneamiento (SaPaS en la ciudad de Culiacán, Sinaloa. Este modelo de evaluación del recurso hídrico está fundamentado en la visión del desarrollo sustentable (DS y en la construcción del sistema de indicadores que integró factores de Presión- Estado-Impacto-Respuesta (PEIR, modelo desarrollado por la organización para la Cooperación y el Desarrollo Económicos (oCDE. Este modelo, se construyó con veinticuatro indicadores organizados en tres categorías para la visión de sustentabilidad y, en cuatro clases que atendieron el modelo PEIR. Finalmente, se estableció un conjunto de conclusiones sobre el discurso teórico y metodológico para construir modelos de valoración del agua urbana.

  9. Uso y valor del recurso hídrico urbano. Sistema de agua potable en Culiacán, México

    Directory of Open Access Journals (Sweden)

    César Domingo Iñíguez Sepúlveda

    2015-03-01

    Full Text Available El propósito de este estudio es construir un sistema para valorar cualitativamente el uso del recurso hídrico como elemento inevitable para el suministro de los servicios de agua potable, alcantarillado y saneamiento (SAPAS en la ciudad de Culiacán, Sinaloa. Este modelo de evaluación del recurso hídrico está fundamentado en la visión del desarrollo sustentable (DS y en la construcción del sistema de indicadores que integró factores de Presión-Estado-Impacto-Respuesta (PEIR, modelo desarrollado por la organización para la Cooperación y el Desarrollo Económicos (OCDE. Este modelo, se construyó con veinticuatro indicadores organizados en tres categorías para la visión de sustentabilidad y, en cuatro clases que atendieron el modelo PEIR. Finalmente, se estableció un conjunto de conclusiones sobre el discurso teórico y metodológico para construir modelos de valoración del agua urbana.

  10. Dry? or Wet? Magma-Water Interaction during Minoan-Thera Eruption of Santorini depicted from 3D morphological analysis of Ashes

    Science.gov (United States)

    Aydar, E.; Ecochard, E.; Çiner, A.; Fouache, E.

    2012-04-01

    Powerful and, catastrophic Minoan-Thera eruption of Santorini occurred at mid-second millennium BC (~3300 BP) produced totally 30 km3 DRE of tephras (Sigurdsson et al., 1990; Pyle, 1990). Magnitude of Minoan-Thera of Santorini Late Bronze Age eruption was estimated as 6 (Colossal) to 7(super colossal) corresponding to Plinian/Ultraplinian style activity according to Volcanic Explosivity Index (McCoy&Heiken,2000). During this one of the largest eruptions in the human history, vent properties and eruption dynamics have changed from dry plinian phase (first phase) to wet phreatomagmatic surges and to pyroclastic flows, comprising of four distinct phases. Convective eruption cloud formed in the first phase was under influence of westerly winds, according to numerous published papers, extending toward east-northeast-southeast, toward Black Sea, Turkey, Mediterannean Sea. We drilled Letoon Plain, southwestern coast of Turkey and cut 3 cm thick tephra deposit overlying an organic material-rich layer dated as 1612 BC (C14, AMS method), corresponding well to the age of Minoan-Thera eruption. The iron content of Minoan-Thera tephras (≥ 2%) is higher than Turkish tephras (in general 2 as polyhedron - multifractal unvesiculated glassy ashes. Meanwhile, blocky-equant ashes have SA/PA nature of the first phase of Minoan-Thera is not purely magmatic as it was classically claimed in most of the previous works.

  11. Effect of flue gas recirculation on heat transfer in a supercritical circulating fluidized bed combustor

    Science.gov (United States)

    Błaszczuk, Artur

    2015-09-01

    This paper focuses on assessment of the effect of flue gas recirculation (FGR) on heat transfer behavior in 1296t/h supercritical coal-fired circulating fluidized bed (CFB) combustor. The performance test in supercritical CFB combustor with capacity 966 MWth was performed with the low level of flue gas recirculation rate 6.9% into furnace chamber, for 80% unit load at the bed pressure of 7.7 kPa and the ratio of secondary air to the primary air SA/PA = 0.33. Heat transfer behavior in a supercritical CFB furnace between the active heat transfer surfaces (membrane wall and superheater) and bed material has been analyzed for Geldart B particle with Sauter mean diameters of 0.219 and 0.246 mm. Bed material used in the heat transfer experiments had particle density of 2700 kg/m3. A mechanistic heat transfer model based on cluster renewal approach was used in this work. A heat transfer analysis of CFB combustion system with detailed consideration of bed-to-wall heat transfer coefficient distributions along furnace height is investigated. Heat transfer data for FGR test were compared with the data obtained for representative conditions without recycled flue gases back to the furnace through star-up burners.

  12. İzmir İlinde Çeşitli Su Kaynaklarındaki Caulobacter'lerin Karakterizasyonu ve Antibiyotik Dirençlerinin İncelenmesi.

    Directory of Open Access Journals (Sweden)

    Aslı Kaçar

    2015-12-01

    Full Text Available Caulobacter, uzantılı bakteriler grubunun farklı bir genusudur. Bu bakteriler, hayat döngüleri boyunca tek flajelli yüzücü hücre ve bir sapa sahip hareketsiz hücre formlarını sırayla oluşturmaktadır. Denizden ve kıyı bölgelerinden olduğu gibi topraktan ve tatlısulardan izole edilebilirler. Bu çalışmada, İzmir ilindeki 10 farklı su kaynağından alınan örneklerden 29 Caulobacter genusu üyesi izole edilmiştir. Yapılan mikroskobik incelemeler ve biyokimyasal testler sonucunda, 9 izolatın C. leidyi, 14’ünün C. variabilis, 6’sının C. intermedius olduğu belirlenmiş ve 7 farklı antibiyotiğin bu bakterilerin büyümesi üzerine etkisi tespit edilmiştir

  13. THE RESPONSE OF BENTHIC MACROINVERTEBRATE AND FISH ASSEMBLAGES TO HUMAN IMPACT ALONG THE LOWER STRETCH OF THE RIVERS MORAVA AND DYJE (DANUBE RIVER BASIN, CZECH REPUBLIC

    Directory of Open Access Journals (Sweden)

    Zdeněk Adámek

    2013-10-01

    Full Text Available The lower Morava and Dyje rivers belong among the large lowland rivers on the southeast of the Czech Republic flowing into the Danube 69 km downstream of their confluence. Despite their high nature value and environment protection, both rivers suffered from heavy pollution from the sixties to the eighties of the last century. Significant improvement of their water quality during the last two decades resulted in the partial recovery of former assemblages of both benthic macroinvertebrates and fish. Recently, altogether 262 and 137 taxa of macrozoobenthos were recorded at the Dyje and Morava rivers, respectively. In the River Dyje, 3 and 21 non-native and threatened (according to IUCN categories invertebrate species, respectively, were ascertained, whilst in the River Morava their numbers were 2 and 10, respectively. The fish assemblage consisted of 23 and 24 species, respectively, plus one hybrid in each of the rivers, bleak being by far the most abundant fish. In the sections under study, several rare and/or protected species were also recorded. Two of them, ide (Leuciscus idus and burbot (Lota lota belong among vulnerable fish species and four others, white-eye bream (Abramis sapa, striped ruffe (Gymnocephalus schraetser, streber (Zingel streber and zingel (Zingel zingel, are considered as critically endangered species. Currently, both lower stretches of the rivers Morava and Dyje have been heavily invaded by round goby, Neogobius melanostomus.

  14. Sakarya D100 (E5 karayolu trafik gürültüsünün değerlendirilmesi

    Directory of Open Access Journals (Sweden)

    Hüseyin Dal

    2016-08-01

    Full Text Available Bu çalışmada, D100 (E5 karayolunun Sakarya güzergâhındaki trafik gürültüsü düzeyleri ölçülmüştür. Bunun için, Esentepe kampüs sapağı ile Sakarya Nehri arasındaki yaklaşık 10 km uzunluğundaki hatta 15 farklı ölçüm noktası belirlenmiştir. Tüm noktalardan 2 aylık süre boyunca, toplam 240 adet gürültü ölçüm alınmıştır. Alınan ölçümler gürültü yönetmelikleri ile birlikte yorumlanmıştır.

  15. The influence of environmental abiotic factors on the qualitative and quantitative structure of ichthyofauna from predeltaic Danube area

    Directory of Open Access Journals (Sweden)

    Petronela Georgiana Calin Sandu

    2013-05-01

    Full Text Available The aim of the paper  is to analyse the influence of environmental factors on the capture and fish communities structure from Danube, between Siret River and Prut River mouth. Fish were collected from April to December 2012 in four fishing areas. During the year, 4910 kg, respectively 7121 fish of 31 species were collected. Cyprinidae, the dominant family, 54.84% in term of number of species, was represented by 17 species (Cyprinus carpio, Carassius gibelio, Barbus barbus, Abramis brama, Abramis sapa, Blicca bjoerkna, Leuciscus idus, Vimba vimba, Aspius aspius, Pelecus cultratus, Chondrostoma nasus, Ctenopharingodon idella, Hypophthalmichthys molitrix, Hypophthalmichthys nobilis, Scardinius erythrophthalmus, Rutilus rutilus, Alburnus alburnus. Other families had the following structure: Percidae (16.13% with 5 species (Sander lucioperca, Zingel zingel, Zingel streber, Perca fluviatilis, Gymnocephalus schraetzer, Acipenseridae (12.90% with 4 species (Huso huso, Acipenser stellatus, Acipenser ruthenus, Acipenser gueldenstaedtii, Clupeidae (6.45% with two species (Alosa immaculata, Alosa tanaica, Siluridae (3.23% with one species (Silurus glanis, Esocidae (3.23% with one species (Esox lucius  and Salmonidae (3.23% with one species also (Salmo labrax. The highest capture was 2977.93 kg (60.65%, during the spring season (April-May, followed by autumn season (September–November, with 992.39 kg (20.21%. The water level and water flow showed high correlation with both number and total catch, respectively.

  16. Pilot genome-wide study of tandem 3' UTRs in esophageal cancer using high-throughput sequencing.

    Science.gov (United States)

    Sun, Mingzhong; Ju, Huixiang; Zhou, Zhongwei; Zhu, Rong

    2014-05-01

    Regulatory regions within the 3' untranslated region (UTR) influence polyadenylation (polyA), translation efficiency, localization and stability of mRNA. Alternative polyA (APA) has been considered to have a key role in gene regulation since 2008. Esophageal carcinoma is the eighth most common type of cancer worldwide. The association between polyA and disease highlights the requirement for comprehensive characterization of genome-wide polyA profiles. In the present study, global polyA profiles were established using the sequencing APA sites (SAPAS) method in order to elucidate the interrelation between 3' UTR length and the development of esophageal cancer. PolyA profiles were analyzed in squamous cell carcinoma, with ~903 genes identified to have shortened 3' UTRs and 917 genes identified to use distal polyA sites. The genes with shortened 3' UTRs were primarily associated with adherens junctions and the cell cycle. Four differentially expressed genes were also found, among which three genes were observed to be upregulated in cancerous tissue and involved in the positive regulation of cell motion, migration and locomotion. One gene was found to be downregulated in cancerous tissue, and associated with oxidative phosphorylation. These findings suggest that esophagitis may have a key role in the development of esophageal carcinoma. Furthermore, the genes with tandem 3' UTRs and differential expression identified in the present study may have the potential to be used as biomarkers for the diagnosis and prognosis of esophageal cancer.

  17. Effect of flue gas recirculation on heat transfer in a supercritical circulating fluidized bed combustor

    Directory of Open Access Journals (Sweden)

    Błaszczuk Artur

    2015-09-01

    Full Text Available This paper focuses on assessment of the effect of flue gas recirculation (FGR on heat transfer behavior in 1296t/h supercritical coal-fired circulating fluidized bed (CFB combustor. The performance test in supercritical CFB combustor with capacity 966 MWth was performed with the low level of flue gas recirculation rate 6.9% into furnace chamber, for 80% unit load at the bed pressure of 7.7 kPa and the ratio of secondary air to the primary air SA/PA = 0.33. Heat transfer behavior in a supercritical CFB furnace between the active heat transfer surfaces (membrane wall and superheater and bed material has been analyzed for Geldart B particle with Sauter mean diameters of 0.219 and 0.246 mm. Bed material used in the heat transfer experiments had particle density of 2700 kg/m3. A mechanistic heat transfer model based on cluster renewal approach was used in this work. A heat transfer analysis of CFB combustion system with detailed consideration of bed-to-wall heat transfer coefficient distributions along furnace height is investigated. Heat transfer data for FGR test were compared with the data obtained for representative conditions without recycled flue gases back to the furnace through star-up burners.

  18. EKSISTENSI DELIK ADAT DI LINGKUNGAN MASYARAKAT SENTOLO, KABUPATEN KULONPROGO YOGYAKARTA

    Directory of Open Access Journals (Sweden)

    Agus Sudaryanto

    2016-05-01

    Full Text Available This research is empirical law research. The collecting data were analyzed by qualitative and presented descriptively. The research can be concluded as follows: reasons for maintaining delict adat law are religious environment, maintaining norms politeness, adat executed as long as no conflict with the written law and the protection of women. Types of sanction are warning in a visit at night, asked to leave the house for interrogation, community sanctions; the reasons of sanction are near the mosque, maintaining delict adat law, neglection of verbal warning, anticipation pregnant before marriage and aruh-aruh culture must be maintained. Jenis penelitian ini adalah yuridis empiris. Data yang terkumpul dianalisis secara kualitatif dan disajikan deskriptif. Kesimpulan riset adalah: Pertama, alasan mempertahankan hukum delik adat karena lingkungan riligius, menjaga norma kesopanan, adat dijalankan asalkan tidak berbenturan dengan peraturan tertulis dan perlindungan perempuan. Kedua, proses penerapan sanksi masyarakat adalah peringatan dalam bertamu di malam hari, diminta keluar rumah untuk diinterogasi, diberi sanksi yang ditentukan musyawarah masyarakat. Ketiga, alasan penjatuhan sanksi pengusiran adalah lingkungan dekat masjid, mempertahankan hukum delik adat, tidak mengindahkan peringatan, pencegahan hamil di luar nikah, perlunya budaya aruharuh (tegur sapa harus dipertahankan.

  19. Longitudinal evaluation of sEMG of masticatory muscles and kinematics of mandible changes in children treated for unilateral cross-bite.

    Science.gov (United States)

    Martín, Conchita; Palma, Juan Carlos; Alamán, Jose Maria; Lopez-Quiñones, Jose Manuel; Alarcón, Jose Antonio

    2012-08-01

    The aim of this study was to evaluate masticatory muscle activity and kinematics of mandible changes in children with unilateral posterior cross-bite (UPXB) after orthodontic treatment, and one year after retention. Twenty-five children with UPXB and functional mandibular shift were evaluated before treatment (mean age 12.5years), after treatment (mean age 14.9years), and one year after retention (mean age 16.8years). The same data were collected in a control group of thirty age-matched normocclusive children. Simultaneous bilateral surface electromyographic (sEMG) activity from anterior temporalis (AT), posterior temporalis (PT), masseter (MA), and supra-hyoid (SH) muscle areas were evaluated at rest, during swallowing, mastication and clenching. Kinematic records of rest position, mandibular lateral shift, swallowing and mastication were analyzed. Results showed a lateral shift of the mandible present at rest. During swallowing, sEMG activity of SH predominated before and post-treatment and retention. High frequency of immature swallowing was maintained post-treatment and retention. During mastication, MA activity increased significantly and its asymmetry was corrected post-treatment. During clenching, cross-bite side AT and MA activity increased significantly posttreatment and remained stable after retention, and MA/AT ratio reversed. These findings reinforce the advantages of treating children with UPXB and functional shift as early as possible. Copyright © 2012 Elsevier Ltd. All rights reserved.

  20. Introduction to the periglacial environment in Finland

    Directory of Open Access Journals (Sweden)

    Seppälä, M.

    1997-12-01

    Full Text Available An overview is presented of the periglacial characteristics of climate and landforms in Finland. Mean annual air temperature (MAAT in Finland ranges from +5.5 to -3°C, and frost sums in most parts of the country are large enough for active seasonal frost. Local conditions are more important in the formation of frost features than the overly general mean values of air temperature, however. Snow depth is the critical factor for most frost features, and permafrost is observed only in northern parts of the country, where thin snow cover supports frost activity. A brief description of features indicating frost activity is presented. Palsas, pounus, and string mires are peat landforms designed by frost. Fell slopes exhibit additional features of talus, slush flows and gelifluction lobes and terraces. Frost heave and contraction cracking are characteristic features occuring even in fields in southern Finland. Active frost-sorted patterned grounds are common in northern Finland, especially at the bottoms of shallow, seasonally dry ponds. Ground water close to the surface is essential for the formation of most frost features. Special forms of both aeolian and fluvial activity are part of the periglacial environment in Finland. Snow drift and deflation of sand surfaces formed by glaciofluvial processes during deglaciation are part of the periglacial environment in Lapland. Drastic spring floods with ice dams formed in river channels are typical for northern rivers. Proposals for further studies are made at the end of the paper.

  1. Real EPC. A method to assess the energy efficiency of newly built houses in practice; Reele EPC. Een methode voor de beoordeling van de energieprestatie van nieuwbouwwoningen in de praktijk

    Energy Technology Data Exchange (ETDEWEB)

    Menkveld, M.; Sipma, J.M. [ECN Beleidsstudies, Petten (Netherlands); Cozijnsen, E.; Leidelmeijer, K. [RIGO research en Advies, Amsterdam (Netherlands)

    2013-12-15

    In this report we describe a method to compare the energy performance in use with the energy performance calculation of newly build houses. We put the average real energy use of a project in the calculation method of the energy performance of new houses. In that way we could compare the energy performance of the building permit with the real performance in practice. Because the calculation method normalizes the energy use of a house by its user surface and surface of building shell, the energy performance of different projects could be compared also when the projects exist of different dwelling types. Also the energy performance of different energy concepts could be compared such as all-electric houses with a heat pump or houses with a gas fired condensing boiler [Dutch] Agentschap NL is betrokken bij veel nieuwbouwprojecten. Een grote vraag is altijd of in de praktijk ook de prestaties worden gehaald die van te voren werden verwacht. Agentschap NL heeft voorgesteld hiervoor een maat te ontwikkelen, namelijk de Reele EPC. ECN heeft deze methodiek uitgewerkt om van woningbouwprojecten de energieprestatie in de praktijk te vergelijken met de geplande EPC. Het idee is dat de energieprestatie in de praktijk wordt uitgedrukt in een reële EPC (de R-EPC)

  2. A naturally-occurring 'cold earth' spot in Northern China.

    Science.gov (United States)

    Niu, Fujun; Cheng, Guodong; Niu, Yonghong; Zhang, Mingyi; Luo, Jing; Lin, Zhanju

    2016-09-29

    Permafrost is determined to a large extent by the Earth's surface temperature, therefore it distributes mainly in high altitude and latitude regions. However, stable, warm (about -1 °C) permafrost occurs within a scree slope in northern China that is more than 600 km south of the southernmost limit of latitudinal permafrost on the Eurasian Continent. It is at an elevation of only 900 m above sea level (ASL). The area has a mean annual air temperature (MAAT) of 6 to 8 °C. Thermal processes of the scree slope, investigated through field monitoring and numerical simulation, showed that the permafrost is caused by winter air convection within the porous rock deposits and is stable as air convection does not occur in summer time. The deposit is covered by a 30-cm-thick peaty soil layer dated (carbon C-14) to between 1,000 to 1,600 years ago. The layer also contributes to the permafrost's existence due to the peat's thermal conductivity offset when frozen and thawed. The existence of permafrost under such warm climatic conditions confirms the effectiveness of using crushed rock layer as basement or slope cover to protect the warm permafrost subgrade of the recently-constructed Qinghai-Tibet Railway (QTR), even under the predicted climate warming conditions.

  3. A naturally-occurring ‘cold earth’ spot in Northern China

    Science.gov (United States)

    Niu, Fujun; Cheng, Guodong; Niu, Yonghong; Zhang, Mingyi; Luo, Jing; Lin, Zhanju

    2016-09-01

    Permafrost is determined to a large extent by the Earth’s surface temperature, therefore it distributes mainly in high altitude and latitude regions. However, stable, warm (about ‑1 °C) permafrost occurs within a scree slope in northern China that is more than 600 km south of the southernmost limit of latitudinal permafrost on the Eurasian Continent. It is at an elevation of only 900 m above sea level (ASL). The area has a mean annual air temperature (MAAT) of 6 to 8 °C. Thermal processes of the scree slope, investigated through field monitoring and numerical simulation, showed that the permafrost is caused by winter air convection within the porous rock deposits and is stable as air convection does not occur in summer time. The deposit is covered by a 30-cm-thick peaty soil layer dated (carbon C-14) to between 1,000 to 1,600 years ago. The layer also contributes to the permafrost’s existence due to the peat’s thermal conductivity offset when frozen and thawed. The existence of permafrost under such warm climatic conditions confirms the effectiveness of using crushed rock layer as basement or slope cover to protect the warm permafrost subgrade of the recently-constructed Qinghai-Tibet Railway (QTR), even under the predicted climate warming conditions.

  4. Harris lines of the tibia across centuries: a comparison of two populations, medieval and contemporary in Central Europe

    Energy Technology Data Exchange (ETDEWEB)

    Ameen, S.; Vock, P.; Anderson, S.E. [University Hospital of Bern, Department of Diagnostic Radiology, Bern (Switzerland); Staub, L.; Ulrich, S. [University of Bern, Institute of Historical Medicine, Bern (Switzerland); Ballmer, F. [University Hospital of Bern, Department of Orthopaedics, Bern (Switzerland)

    2005-05-01

    To determine the incidence of Harris lines in two medieval populations which inhabited the Canton of Berne, in Central Switzerland, and to compare the results with those of a contemporary population living in the same geographical area. A simplified method is described for measuring the age of the individual at the time of formation of Harris lines, with possible future applications. Radiographs of 112 well-preserved tibiae of skeletons of two medieval populations from the eighth to fifteenth centuries were reviewed for the incidence of Harris lines. The results were compared with those of 138 current patients living in the same geographic location in Central Switzerland. Age and gender of the medieval individual were determined using known anthropological methods. Age of bone at the time of formation of Harris lines was estimated according to the method of Maat. Harris lines were found in 88 of 112 (80%) of the examined medieval skeletons and in 28 of 138 (20%) of the living individuals. Higher incidences of Harris lines were found at the age of 2 years and at ages between 8 and 12 years in both populations. No gender difference was found regarding the incidence of Harris lines. In both populations the occurrence of Harris lines was associated with certain diseases such as degenerative bone disease, trauma, osteoporosis, rheumatoid arthritis, peripheral vascular diseases, rickets and bony deformities. (orig.)

  5. 小学生学习障碍与学习动机、学习能力的相关研究%Research on the Learning Disabilities, Motivation and Ability of Pupils

    Institute of Scientific and Technical Information of China (English)

    潘玉进; 陈凤燕

    2006-01-01

    本研究采用中小学生团体智力筛选测验和LD行为量表从332名小学三、五年级儿童中筛选出50名小学LD儿童,检出率为15.06%,并对其进行学习动机诊断测验(MAAT)和提高学习能力因素诊断测验(FAT),以探讨小学儿童学习障碍的可能成因.结果表明:(1)60%的小学LD儿童表现为理解能力不足;(2)在MAAT与FAT各因素中,对小学LD儿童基本学习能力影响最重要的因素是在校学习方法、心理健康、身体健康、自己责任性、FAT总分,其次是考试焦虑-回避失败动机、在家学习方法、成功动机及其技能场面.可以认为影响小学LD儿童的主要因素是学习方法、学习动机和身心健康.

  6. Noble gas signatures in the Island of Maui, Hawaii: Characterizing groundwater sources in fractured systems

    Science.gov (United States)

    Niu, Yi; Castro, M. Clara; Hall, Chris M.; Gingerich, Stephen B.; Scholl, Martha A.; Warrier, Rohit B.

    2017-01-01

    Uneven distribution of rainfall and freshwater scarcity in populated areas in the Island of Maui, Hawaii, renders water resources management a challenge in this complex and ill-defined hydrological system. A previous study in the Galapagos Islands suggests that noble gas temperatures (NGTs) record seasonality in that fractured, rapid infiltration groundwater system rather than the commonly observed mean annual air temperature (MAAT) in sedimentary systems where infiltration is slower thus, providing information on recharge sources and potential flow paths. Here we report noble gas results from the basal aquifer, springs, and rainwater in Maui to explore the potential for noble gases in characterizing this type of complex fractured hydrologic systems. Most samples display a mass-dependent depletion pattern with respect to surface conditions consistent with previous observations both in the Galapagos Islands and Michigan rainwater. Basal aquifer and rainwater noble gas patterns are similar and suggest direct, fast recharge from precipitation to the basal aquifer. In contrast, multiple springs, representative of perched aquifers, display highly variable noble gas concentrations suggesting recharge from a variety of sources. The distinct noble gas patterns for the basal aquifer and springs suggest that basal and perched aquifers are separate entities. Maui rainwater displays high apparent NGTs, incompatible with surface conditions, pointing either to an origin at high altitudes with the presence of ice or an ice-like source of undetermined origin. Overall, noble gas signatures in Maui reflect the source of recharge rather than the expected altitude/temperature relationship commonly observed in sedimentary systems.

  7. A naturally-occurring ‘cold earth’ spot in Northern China

    Science.gov (United States)

    Niu, Fujun; Cheng, Guodong; Niu, Yonghong; Zhang, Mingyi; Luo, Jing; Lin, Zhanju

    2016-01-01

    Permafrost is determined to a large extent by the Earth’s surface temperature, therefore it distributes mainly in high altitude and latitude regions. However, stable, warm (about −1 °C) permafrost occurs within a scree slope in northern China that is more than 600 km south of the southernmost limit of latitudinal permafrost on the Eurasian Continent. It is at an elevation of only 900 m above sea level (ASL). The area has a mean annual air temperature (MAAT) of 6 to 8 °C. Thermal processes of the scree slope, investigated through field monitoring and numerical simulation, showed that the permafrost is caused by winter air convection within the porous rock deposits and is stable as air convection does not occur in summer time. The deposit is covered by a 30-cm-thick peaty soil layer dated (carbon C-14) to between 1,000 to 1,600 years ago. The layer also contributes to the permafrost’s existence due to the peat’s thermal conductivity offset when frozen and thawed. The existence of permafrost under such warm climatic conditions confirms the effectiveness of using crushed rock layer as basement or slope cover to protect the warm permafrost subgrade of the recently-constructed Qinghai-Tibet Railway (QTR), even under the predicted climate warming conditions. PMID:27685441

  8. “kkw y kkw-zmAw. Un estudio del concepto de oscuridad en la Duat de los Libros del Más Allá del Reino Nuevo Egipcio”

    Directory of Open Access Journals (Sweden)

    Mariano Bonanno

    2017-06-01

    Full Text Available Los Libros del Más Allá del Reino Nuevo hablan incesantemente del estado pre y post paso de Ra por la Duat. El contexto de oscuridad revierte en luz, calor y movimiento con su presencia, para los difuntos que en la tierra actuaron conforme a mAat; los condenados, por el contrario, sufrían las puniciones consecuencia de su iniquidad. Los egipcios disponían de varios vocablos para aludir a la idea de oscuridad, pero sin lugar a dudas kkw y kkw-zmAw son los que más controversia nos generan dada la falta de límites y las eventuales superposiciones que entre ambas acepciones se producen. El presente artículo propone, además de profundizar los pioneros estudios de Hornung (1956a y 1956b, revisar ambos conceptos, contextualizarlos a los libros funerarios del Reino Nuevo -Libro del Amduat, Libro de las Puertas, Libro de las Cavernas y Libro de la Tierra-, y poner en consideración las definiciones que taxativamente proponen espacios y áreas de influencia precisas

  9. Boekbesprekingen / Comptes Rendus

    Directory of Open Access Journals (Sweden)

    Willem Frijhoff

    2016-12-01

    Full Text Available Book reviews/ Boekbesprekingen/ Comptes Rendus:Quatrième Livre des procurateurs de la Nation Germanique de l'ancienne Université d'Orléans 1587-1602. Textes des rapports des procurateurs. Édité par Cornelia M. Ridderikhoff et Hilde de Ridder-Symoens. Education and Society in the Middle Ages and Renaissance 49 (Leiden, Boston: Brill 2015 676 pp., ISBN 978-90-04-28763-1. € 172.E. Jorink en B. Ramakers (eds., Art and Science in the early Modern Netherlands – Kunst en wetenschap in de vroegmoderne Nederlanden. Nederlands Kunsthistorisch jaarboek 61 (Zwolle: W Books 2011 367 pp., ill., ISBN 978-90-400-7808-8. € 113.Ernst Cohen, Na driekwart eeuw. Levensherinneringen, F. Broeyer en L. Dorsman (eds. (Utrecht: Uitgeverij Matrijs 2013 448 pp., ill. ISBN 978-90-5345-468-8. € 29,95; Leen Dorsman en P.J. Knegtmans (eds., De menselijke maat in de wetenschap. De geleerden(autobiografie als bron voor de wetenschaps- en universiteitsgeschiedenis (Hilversum: Verloren 2013 136 pp., ill., ISBN 9789087043971. € 14.J. van Dongen, F. Hoeneveld and A. Streefland (eds., Cold War Science and the Transatlantic Circulation of Knowledge (Leiden: Brill 2015 293 pp., ISBN 978-90-04-26421-2. €115.David Baneke, De ontdekkers van de hemel. De Nederlandse sterrenkunde in de twintigste eeuw (Amsterdam: Prometheus Bert Bakker 2015 384 pp., ill., ISBN 978 90 351 3688 5. € 24,95.

  10. The Way of Making Friends in the Ancient Egyptian Literature of Preaching%古埃及说教文中的交友之道

    Institute of Scientific and Technical Information of China (English)

    王磊

    2015-01-01

    Since the ancient Egyptians advocated the concept of justice,they regarded Maat as their one of the vital principles of making friends.Although particular interests was important in the processing of making friends,the wise reminded the young that only the man with a sense of justice could have true friends.These phenomena have been recorded in the ancient Egyptian literature of preaching.The way of making friends in ancient Egyptian literature of preaching is not only to be sincere,friendly and tolerant, but also to give advice and guidance on how to get along with people who are not available.%古埃及社会崇尚正义。正义观念成为指导古代埃及人交友的重要原则之一。在流传至今的古埃及说教文中,智者们时刻提醒年轻人,只有恪守正义,才能交到真正的朋友。古埃及说教文中所涉及的交友之道,不仅包括对待朋友要真诚、友善和宽容,还包括对如何与不可交之人相处所给出的相关建议与指导。

  11. Investigation of Current Situation of Learning Motivation, Social Anxiety and Loneliness of the Left-behind Children in Rural Primary School

    Directory of Open Access Journals (Sweden)

    Zhang Biyun

    2015-01-01

    Full Text Available Objective: To understand the situation of learning motivation, social anxiety and loneliness of the left-behind children. Method: Selecting three rural primary schools in Xian’an District of Xianning City to investigate left-behind situation, learning motivation, social anxiety and loneliness of pupils in Grades 4 to 6 in rural primary school in Xian’an District by the use of the MAAT-I-A which is revised by Zhou Bucheng, the Social Anxiety Scale for Children (SASC and the Children’s Loneliness Scale (CLS. Results: (1 The learning motivation of the left-behind children in rural primary school is in a slightly higher medium level. Social anxiety is significantly higher than normal level in Chinese city, and the level of loneliness of about 1/5 of the left-behind children is relatively high. (2 The score of learning motivation, social anxiety and loneliness of the left-behind children in the level of knowledge learning has significant grade differences, without significant gender differences. (3 The level of learning motivation, social anxiety and loneliness of the left-behind children is slightly higher than that of non-left-behind children, but both differences are not significant.

  12. Permafrost and Periglacial Activity Distribution and Geothermal Anomalies in the Chachani and El Misti Volcanoes (Southern Peru)

    Science.gov (United States)

    Palacios, D.; Andrés, N.; Úbeda, J.; Alcalá, J.

    2009-04-01

    because it never existed. In the latter case, considering its altitude and the conditions in the extinct Chachani and Pichupichu volcanoes nearby, that no evidence is available could be due to the action of geothermal heat, as this is an active volcano. With this aim, three thermal stations were established on El Misti, at altitudes of 4780, 5438 and 5740 m, consisting of an air temperature sensor and a ground temperature sensor, installed at a depth of 20 cm. When possible, a third sensor was installed in the ground at a depth of 40 to 100 cm. Three stations were also installed on the Chachani volcano, at altitudes of 4871, 5013 and 5352 m, with the same orientation where possible, and with the same sensor types and positions. Data was collected during the period 2004-2008. Results obtained for the Chachani volcano during the four complete years for which data is available are fairly uniform, despite the occasional failure of some sensors. For the air temperature, the 0°C mean annual temperature (MAAT) isotherm is situated at around 5000 m altitude, and the -2°C isotherm, which we consider the limit of probable permafrost (Palacios et al. 2007), at around 5300 m. At 5352 m, permafrost was not detected at a depth of 40 cm, with 78 days above 0°C, although it may exist and may be detectable using a deeper probe. The daily temperature range is always very wide, with an average daily range of around 8°C and a maximum daily range of up to 20°C. The number of days where the temperature oscillates above and below 0°C (freeze-thaw cycles) is practically nil at an altitude of 4870 m (between 0 and 75 cycles/year), and maximum at 5013 m (around 200 cycles/year). It then decreases as the altitude increases, with fewer than 150 cycles/year at 5352 m. The data from the ground sensors shows that the mean annual temperatures from the ground thermometers (MAGTs) are slightly higher (2°C on average) than from the air thermometers, including those at a depth of 100 cm. In

  13. El aceite de pescado atenua las crisis convulsivas inducidas por hipertermia en ratas neonatas

    Directory of Open Access Journals (Sweden)

    Leopoldo E. Flores M.

    2008-01-01

    Full Text Available Un alto porcentaje (50-60% del cerebro en los mamíferos son principalmente grasas o lípidos, de éstos, el 35% son ácidos grasos esenciales, en particular los llamados omegas (O, como el Acido Docosahexanoico (DHA y el Eicosapentanoico (EPA llamados omega 3 (O-3. Diversos estudios han mostrado beneficios en la salud con la implementación de los O-3 como agentes terapéuticos en alteraciones cardiovasculares, renales, dérmicas, metabólicas, neurodegenerativas e inmunológicas. Evidencias experimentales sugieren un beneficio potencial del aceite de pescado (APE como neuroprotector debido al alto contenido de DHA y EPA. Sin embargo, es poco lo que se conoce en cuanto a los efectos que pudieran tener sobre alteraciones nerviosas, como las crisis convulsivas. En este contexto, se ha reportado que el tipo más común de trastorno epiléptico observado en los niños son las crisis convulsivas provocadas por fiebre (CF. La incidencia es de 3-5%, con ocurrencia entre los 5 meses y 5 años de edad, y se ha propuesto que esta alteración en la vida temprana pudiera tener efectos a largo plazo, manifestándose como un síndrome de epilepsia en la vida adulta. El objetivo del presente estudio fue evaluar el efecto del APE sobre las convulsiones inducidas por hipertermia experimental en un grupo de ratas Wistar macho de 5 días de edad (grupo SAPE cuyas madres consumieron una dieta base más un suplemento de APE (suministrado desde su infancia hasta la etapa de crianza. Este grupo se comparó con otro grupo de ratas de la misma edad y cepa (grupo SAPA cuyas madres consumieron una dieta base más un suplemento de aceite de palma (suministrado desde su infancia hasta la etapa de crianza, y con un tercer grupo de ratas (grupo CTRL cuyas madres consumieron la dieta base más agua bidestilada como suplemento. Las ratas tratadas con APE presentaron mayor resistencia a la elevación de la temperatura corporal inducida por la hipertermia, una menor frecuencia

  14. Comparative Genomics of Campylobacter fetus from Reptiles and Mammals Reveals Divergent Evolution in Host-Associated Lineages.

    Science.gov (United States)

    Gilbert, Maarten J; Miller, William G; Yee, Emma; Zomer, Aldert L; van der Graaf-van Bloois, Linda; Fitzgerald, Collette; Forbes, Ken J; Méric, Guillaume; Sheppard, Samuel K; Wagenaar, Jaap A; Duim, Birgitta

    2016-07-02

    Campylobacter fetus currently comprises three recognized subspecies, which display distinct host association. Campylobacter fetus subsp. fetus and C fetus subsp. venerealis are both associated with endothermic mammals, primarily ruminants, whereas C fetus subsp. testudinum is primarily associated with ectothermic reptiles. Both C. fetus subsp. testudinum and C. fetus subsp. fetus have been associated with severe infections, often with a systemic component, in immunocompromised humans. To study the genetic factors associated with the distinct host dichotomy in C. fetus, whole-genome sequencing and comparison of mammal- and reptile-associated C fetus was performed. The genomes of C fetus subsp. testudinum isolated from either reptiles or humans were compared with elucidate the genetic factors associated with pathogenicity in humans. Genomic comparisons showed conservation of gene content and organization among C fetus subspecies, but a clear distinction between mammal- and reptile-associated C fetus was observed. Several genomic regions appeared to be subspecies specific, including a putative tricarballylate catabolism pathway, exclusively present in C fetus subsp. testudinum strains. Within C fetus subsp. testudinum, sapA, sapB, and sapAB type strains were observed. The recombinant locus iamABC (mlaFED) was exclusively associated with invasive C fetus subsp. testudinum strains isolated from humans. A phylogenetic reconstruction was consistent with divergent evolution in host-associated strains and the existence of a barrier to lateral gene transfer between mammal- and reptile-associated C fetus Overall, this study shows that reptile-associated C fetus subsp. testudinum is genetically divergent from mammal-associated C fetus subspecies.

  15. Comparative Genomics of Campylobacter fetus from Reptiles and Mammals Reveals Divergent Evolution in Host-Associated Lineages

    Science.gov (United States)

    Gilbert, Maarten J.; Miller, William G.; Yee, Emma; Zomer, Aldert L.; van der Graaf-van Bloois, Linda; Fitzgerald, Collette; Forbes, Ken J.; Méric, Guillaume; Sheppard, Samuel K.; Wagenaar, Jaap A.; Duim, Birgitta

    2016-01-01

    Campylobacter fetus currently comprises three recognized subspecies, which display distinct host association. Campylobacter fetus subsp. fetus and C. fetus subsp. venerealis are both associated with endothermic mammals, primarily ruminants, whereas C. fetus subsp. testudinum is primarily associated with ectothermic reptiles. Both C. fetus subsp. testudinum and C. fetus subsp. fetus have been associated with severe infections, often with a systemic component, in immunocompromised humans. To study the genetic factors associated with the distinct host dichotomy in C. fetus, whole-genome sequencing and comparison of mammal- and reptile-associated C. fetus was performed. The genomes of C. fetus subsp. testudinum isolated from either reptiles or humans were compared with elucidate the genetic factors associated with pathogenicity in humans. Genomic comparisons showed conservation of gene content and organization among C. fetus subspecies, but a clear distinction between mammal- and reptile-associated C. fetus was observed. Several genomic regions appeared to be subspecies specific, including a putative tricarballylate catabolism pathway, exclusively present in C. fetus subsp. testudinum strains. Within C. fetus subsp. testudinum, sapA, sapB, and sapAB type strains were observed. The recombinant locus iamABC (mlaFED) was exclusively associated with invasive C. fetus subsp. testudinum strains isolated from humans. A phylogenetic reconstruction was consistent with divergent evolution in host-associated strains and the existence of a barrier to lateral gene transfer between mammal- and reptile-associated C. fetus. Overall, this study shows that reptile-associated C. fetus subsp. testudinum is genetically divergent from mammal-associated C. fetus subspecies. PMID:27333878

  16. Development and evaluation of an indirect enzyme-linked immunosorbent assay for the detection of antibodies against Campylobacter fetus in cattle.

    Science.gov (United States)

    Zhao, Hailing; Liu, Huifang; Du, Yanfen; Liu, Siguo; Ni, Hongbo; Wang, Yong; Wang, Chunlai; Si, Wei; Yang, Jinguo; Ling, Jingkai

    2010-06-01

    Campylobacteriosis is a zoonosis that occurs worldwide. Infection with Campylobacter fetus (C. fetus) causes infertility and abortion in sheep and cattle. The current study focuses on the SapA gene of C. fetus that encodes surface array proteins and plays an important role in the virulence of C. fetus. The SapA-N (1398bp) and SapA-C (1422bp) fragments were amplified from the C. fetusSapA gene using polymerase chain reaction (PCR), and the corresponding recombinant proteins rSapA-N and rSapA-C were expressed in Escherichia. coli BL21 cells. Results of Western blotting and enzyme-linked immunosorbent assay (ELISA) showed that the immunological activity of rSapA-N was higher than that of rSapA-C (PELISA for detecting antibodies against C. fetus. The diagnostic criteria were as follows: S/P0.45: positive; S/PS/P0.4: suspected. The specificity and sensitivity of our method were 94.3% and 88.6%, respectively. Moreover, no cross-reactions were observed between rSapA-N and serum samples that were positive for other bovine bacterial pathogens diseases such as Mycobacterium avium subspecies paratuberculosis. One hundred and two serum samples from cows that had experienced abortion were tested. Four and 2 C. fetus-positive serum samples were found among the 70 bovine brucellosis-positive samples and the 32 infectious bovine rhinotracheitis (IBR)-positive samples, respectively. The findings suggest that the rSapA-N-based ELISA method has immense potential in future applications. Copyright 2009 Elsevier Ltd. All rights reserved.

  17. Morphological polymorphism in tapeworms: redescription of Caryophyllaeus laticeps (Pallas, 1781) (Cestoda: Caryophyllidea) and characterisation of its morphotypes from different fish hosts.

    Science.gov (United States)

    Hanzelová, Vladimíra; Oros, Mikuláš; Barčák, Daniel; Miklisová, Dana; Kirin, Diana; Scholz, Tomáš

    2015-02-01

    Recent morphological and molecular data have shown that one of the most common parasites of freshwater fish in the Palaearctic Region, the cestode Caryophyllaeus laticeps (Pallas, 1781) (Eucestoda: Caryophyllidea), is highly polymorphic. Five distinct morphotypes of C. laticeps, largely corresponding to different fish hosts and representing separate, yet closely related genetic lineages, have been recognised and they are characterised in the present paper. Morphotype 1 from breams, Abramis brama (L.) (type-host) and Ballerus spp., corresponds to the original Taenia laticeps Pallas, 1781 and its neotype (paragenophore ex A. brama in Russia) is designated. This morphotype is characterised by a slender body and flabellate scolex. Morphotype 2 was found in the Macedonian vimba Vimba melanops (Heckel) and the vimba bream V. vimba (L.); it is typified by a more robust body, with most anterior extent of the vitelline follicles near the scolex and the cirrus-sac situated more anteriorly than in other morphotypes. Morphotype 3 is represented by worms from the common carp Cyprinus carpio L. that possess a cuneicrispitate scolex (having the form of a wedge with shallow indentations on anterior margin). Morphotype 4 from the common nase Chondrostoma nasus (L.) has a large, robust body and a wide scolex with numerous superficial grooves (wrinkles) in its anterior part. Morphotype 5 is represented by worms from the white-eye bream Ballerus sapa (Pallas); its typical characteristics are a festoon-like anterior margin of the scolex, the absence of vitelline follicles posterior to the cirrus-sac and the absence of a well-developed internal seminal vesicle. Discriminant analysis of 15 morphometric variables readily separated Morphotypes 3, 4 and 5 and confirmed the key discriminating power of traits related to the reproductive system, especially the terminal reproductive organs. Morphological polymorphism and the genetic divergence of different morphotypes of C. laticeps correspond

  18. Transcriptomic analysis of liquid non-sporulating Streptomyces coelicolor cultures demonstrates the existence of a complex differentiation comparable to that occurring in solid sporulating cultures.

    Science.gov (United States)

    Yagüe, Paula; Rodríguez-García, Antonio; López-García, María Teresa; Rioseras, Beatriz; Martín, Juan Francisco; Sánchez, Jesús; Manteca, Angel

    2014-01-01

    Streptomyces species produce many clinically relevant secondary metabolites and exhibit a complex development that includes hyphal differentiation and sporulation in solid cultures. Industrial fermentations are usually performed in liquid cultures, conditions in which Streptomyces strains generally do not sporulate, and it was traditionally assumed that no differentiation took place. The aim of this work was to compare the transcriptomes of S. coelicolor growing in liquid and solid cultures, deepening the knowledge of Streptomyces differentiation. Microarrays demonstrated that gene expression in liquid and solid cultures were comparable and data indicated that physiological differentiation was similar for both conditions. Eighty-six percent of all transcripts showed similar abundances in liquid and solid cultures, such as those involved in the biosynthesis of actinorhodin (actVA, actII-4) and undecylprodigiosin (redF); activation of secondary metabolism (absR1, ndsA); genes regulating hydrophobic cover formation (aerial mycelium) (bldB, bldC, bldM, bldN, sapA, chpC, chpD, chpE, chpH, ramA, ramC, ramS); and even some genes regulating early stages of sporulation (wblA, whiG, whiH, whiJ). The two most important differences between transcriptomes from liquid and solid cultures were: first, genes related to secondary metabolite biosynthesis (CDA, CPK, coelichelin, desferrioxamine clusters) were highly up-regulated in liquid but not in solid cultures; and second, genes involved in the final stages of hydrophobic cover/spore maturation (chpF, rdlA, whiE, sfr) were up-regulated in solid but not in liquid cultures. New information was also provided for several non-characterized genes differentially expressed in liquid and solid cultures which might be regulating, at least in part, the metabolic and developmental differences observed between liquid and solid cultures.

  19. Transcriptomic analysis of liquid non-sporulating Streptomyces coelicolor cultures demonstrates the existence of a complex differentiation comparable to that occurring in solid sporulating cultures.

    Directory of Open Access Journals (Sweden)

    Paula Yagüe

    Full Text Available Streptomyces species produce many clinically relevant secondary metabolites and exhibit a complex development that includes hyphal differentiation and sporulation in solid cultures. Industrial fermentations are usually performed in liquid cultures, conditions in which Streptomyces strains generally do not sporulate, and it was traditionally assumed that no differentiation took place. The aim of this work was to compare the transcriptomes of S. coelicolor growing in liquid and solid cultures, deepening the knowledge of Streptomyces differentiation. Microarrays demonstrated that gene expression in liquid and solid cultures were comparable and data indicated that physiological differentiation was similar for both conditions. Eighty-six percent of all transcripts showed similar abundances in liquid and solid cultures, such as those involved in the biosynthesis of actinorhodin (actVA, actII-4 and undecylprodigiosin (redF; activation of secondary metabolism (absR1, ndsA; genes regulating hydrophobic cover formation (aerial mycelium (bldB, bldC, bldM, bldN, sapA, chpC, chpD, chpE, chpH, ramA, ramC, ramS; and even some genes regulating early stages of sporulation (wblA, whiG, whiH, whiJ. The two most important differences between transcriptomes from liquid and solid cultures were: first, genes related to secondary metabolite biosynthesis (CDA, CPK, coelichelin, desferrioxamine clusters were highly up-regulated in liquid but not in solid cultures; and second, genes involved in the final stages of hydrophobic cover/spore maturation (chpF, rdlA, whiE, sfr were up-regulated in solid but not in liquid cultures. New information was also provided for several non-characterized genes differentially expressed in liquid and solid cultures which might be regulating, at least in part, the metabolic and developmental differences observed between liquid and solid cultures.

  20. 中国刺蛾科六新种和十二新纪录种(鳞翅目,斑蛾总科)%SIX NEW SPECIES AND TWELVE NEWLY RECORDED SPECIES OF LIMACODIDAE FROM CHINA(LEPIDOPTERA,ZYGAENOIDEA)

    Institute of Scientific and Technical Information of China (English)

    武春生

    2011-01-01

    Six new species, Caissa staurognatha sp. nov., Miresa dicrognatha sp. nov., Limacolasia hyalodesa sp. nov., Austrapoda beijingensis sp. nov., Parasa solovyevi sp. nov. and Striogyia obatera sp. nov., are described and illustrated from China. Five genera and twelve species are reported for the first time in China.%报道中国刺蛾科6新种、5新纪录属及12新纪录种.新种包括:岔颚凯刺蛾 Caissa staurognatha sp.nov.、叉颚银纹刺蛾Miresa dicrognatha sp.nov.、透翅泥刺蛾Limacolasia hyalodesa sp.nov.、北京歧刺蛾.Austrapoda beijingensis sp.nov.、索洛绿刺蛾Parasa solovyevi sp.nov.及黑条刺蛾Striogyia obatera sp.nov..条刺蛾属 Striogyia Holloway、佳刺蛾属Euphlyctinides Hering、温刺蛾属 Prapata Holloway、裔刺蛾属Hindothosea Holloway和白刺蛾属Pseudaltha Hering 为我国新纪录属.黑基客刺蛾Ceratonema nigribasale Hering、拟焰刺蛾Pseudiragoides spadix Solovyev et Witt、铜翅佳刺蛾Euphlyctintides aeneola Solovyev、叶奇刺蛾 Matsumurides lola(Swinhoe)、温刺蛾Prapata bisinuosa、黑温刺蛾Prapata scotopepla (Hampson)、赭背刺蛾 Belippa ochreata Yoshimoto、裔刺蛾Hindothosea cervina(Moore)、纷刺蛾 Griseothosea cruda (Walker)、白翅姹刺蛾Chalcocelis albor Solovyev et Witt、维绒刺蛾Phocoderma witti Solovyev和沙坝白刺蛾 Pseudaltha sapa Solovyev为中国新纪录种.模式标本保存在中国科学院动物研究所国家动物博物馆昆虫标本馆(IZCAS).

  1. Cloning, production, and functional expression of the bacteriocin sakacin A (SakA) and two SakA-derived chimeras in lactic acid bacteria (LAB) and the yeasts Pichia pastoris and Kluyveromyces lactis.

    Science.gov (United States)

    Jiménez, Juan J; Borrero, Juan; Diep, Dzung B; Gútiez, Loreto; Nes, Ingolf F; Herranz, Carmen; Cintas, Luis M; Hernández, Pablo E

    2013-09-01

    Mature sakacin A (SakA, encoded by sapA) and its cognate immunity protein (SakI, encoded by sapiA), and two SakA-derived chimeras mimicking the N-terminal end of mature enterocin P (EntP/SakA) and mature enterocin A (EntA/SakA) together with SakI, were fused to different signal peptides (SP) and cloned into the protein expression vectors pNZ8048 and pMG36c for evaluation of their production and functional expression by different lactic acid bacteria. The amount, antimicrobial activity, and specific antimicrobial activity of SakA and its chimeras produced by Lactococcus lactis subsp. cremoris NZ9000 depended on the SP and the expression vector. Only L. lactis NZ9000 (pNUPS), producing EntP/SakA, showed higher bacteriocin production and antimicrobial activity than the natural SakA-producer Lactobacillus sakei Lb706. The lower antimicrobial activity of the SakA-producer L. lactis NZ9000 (pNUS) and that of the EntA/SakA-producer L. lactis NZ9000 (pNUAS) could be ascribed to secretion of truncated bacteriocins. On the other hand, of the Lb. sakei Lb706 cultures transformed with the pMG36c-derived vectors only Lb. sakei Lb706 (pGUS) overproducing SakA showed a higher antimicrobial activity than Lb. sakei Lb706. Finally, cloning of SakA and EntP/SakA into pPICZαA and pKLAC2 permitted the production of SakA and EntP/SakA by recombinant Pichia pastoris X-33 and Kluyveromyces lactis GG799 derivatives although their antimicrobial activity was lower than expected from their production.

  2. Characterization of chromosomal qnrB and ampC alleles in Citrobacter freundii isolates from different origins.

    Science.gov (United States)

    Liao, Xiaoping; Fang, Liangxing; Li, Liang; Sun, Jian; Li, Xingping; Chen, Muya; Deng, Hui; Yang, Qiu'e; Li, Xue; Liu, Yahong

    2015-10-01

    The association of ESBLs (extended-spectrum beta-lactamases)/pAmpCs (plasmid-mediated AmpC β-lactamases) with PMQR (plasmid mediated quinolone resistance) in gram-negative bacteria has been of great concern. The present study was performed to characterize the diversity, gene location, genetic context, and evolution of ampC and qnrB alleles in isolates of Citrobacter freundii. Fifteen isolates of C. freundii were identified from a total of 788 isolates of Enterobacteriaceae derived from humans, animals, animal food products, and the environment between 2010 and 2012. Co-existence of qnrB/ΔqnrB with ampC was detected in all C. freundii isolates. Both ampC and qnrB genes were found to be located on the chromosome, but were distantly separated on the chromosome. Seven and six novel alleles were discovered for the 10 ampC and qnrB variants detected in this study, respectively. Phylogenetic analysis showed that the new alleles differed a little from the variants of ampC/qnrB previously described in this genus. The genetic context surrounding ampC genes was AmpR-AmpC-Blc-SugE. However, five different genetic contexts surrounding qnrB/ΔqnrB genes were observed, but they occurred in all cases between the pspF and sapA genes. Additionally, cloning experiments showed that the regions containing different qnrB alleles, even with different genetic contexts, contributed to the reduction of quinolone susceptibility. Our results showed that the chromosomal ampC and qnrB alleles are closely related to C. freundii. However, unlike ampC, qnrB alleles seemed to be related to the genetic contexts surrounding them. The evolution of these two genes in C. freundii isolates might be through different pathways.

  3. Phylogeny and Comparative Genomics Unveil Independent Diversification Trajectories of qnrB and Genetic Platforms within Particular Citrobacter Species.

    Science.gov (United States)

    Ribeiro, Teresa G; Novais, Ângela; Branquinho, Raquel; Machado, Elisabete; Peixe, Luísa

    2015-10-01

    To gain insights into the diversification trajectories of qnrB genes, a phylogenetic and comparative genomics analysis of these genes and their surrounding genetic sequences was performed. For this purpose, Citrobacter sp. isolates (n = 21) and genome or plasmid sequences (n = 56) available in public databases harboring complete or truncated qnrB genes were analyzed. Citrobacter species identification was performed by phylogenetic analysis of different genotypic markers. The clonal relatedness among isolates, the location of qnrB genes, and the genetic surroundings of qnrB genes were investigated by pulsed-field gel electrophoresis (PFGE), S1-/I-CeuI-PFGE and hybridization, and PCR mapping and sequencing, respectively. Identification of Citrobacter isolates was achieved using leuS and recN gene sequences, and isolates characterized in this study were diverse and harbored chromosomal qnrB genes. Phylogenetic analysis of all known qnrB genes revealed seven main clusters and two branches, with most of them included in two clusters. Specific platforms (comprising pspF and sapA and varying in synteny and/or identity of other genes and intergenic regions) were associated with each one of these qnrB clusters, and the reliable identification of all Citrobacter isolates revealed that each platform evolved in different recognizable (Citrobacter freundii, C. braakii, C. werkmanii, and C. pasteurii) and putatively new species. A high identity was observed between some of the platforms identified in the chromosome of Citrobacter spp. and in different plasmids of Enterobacteriaceae. Our data corroborate Citrobacter as the origin of qnrB and further suggest divergent evolution of closely related qnrB genes/platforms in particular Citrobacter spp., which were delineated using particular genotypic markers.

  4. [Validation of a French translation of Krueger's personality inventory for DSM-5 in its brief form (PID-5 BF)].

    Science.gov (United States)

    Combaluzier, S; Gouvernet, B; Menant, F; Rezrazi, A

    2016-09-27

    Since the publication of the DSM-5 (APA, 2013), the dimensional conception of the personality disorders is co-existing with the classical categorical paradigm. Tools have been proposed for the evaluations of five big pathological factors to be explored further according to the APA (negative affectivity, detachment, antagonism, disinhibition, psychoticism). Despite numerous works using these questionnaires (30 works in 3 years according to Al-Adjani et al., 2015), none of them have yet been translated into French. Also, the main objective of the paper is to present a French translation of the Personality Inventory for DSM -5 by Kruegger et al. (2013) in its brief form of 25 items (PID-5 BF). To reach this goal, we have employed the classic translation-retranslation method (Vallerand, 1989) and tested the consistence and the validity of this French version among a non-clinical sample (n=216) of young adults (age=31.4, SD=4.8), in joining some other questionnaires in their short forms to study the external validity of the PID-5 about the psychological distress (SCL-10, Nguyen, 1983), the categorical diagnosis of personality disorders (SAPAS, Moran et al., 2003) and the classical Big Five dimensions of the personality (BDI 10, Ramamstedt and John, 2007). The internal consistency of this translation has been studied through the classical outcomes on factor analysis for the dimensional repartitions of the items in 5 scales and Cronbach's alpha for the consistency of each found dimensions. The external validity has been explored by studying Pearson's correlations between the outcomes on each dimension of the PID-5 BF and both the clinical dimensions of SCL-10, personality dimensions of the BFI-10 or personality disorders (SAPAS). Factor analysis led to the same repartition of the 25 items as the original versions. Each of the dimensions is consistent enough (α>.65) to be taken into account as clinically significant. The items of the French version of the PID-5 BF follow

  5. Ground surface thermal regime of rock glaciers in the High Tatra Mts., Slovakia

    Science.gov (United States)

    Uxa, Tomáš; Mida, Peter

    2017-04-01

    mean annual air temperature (MAAT), which averaged +2.3 ˚ C in both years (estimated from nearby Lomnický štít station using a lapse rate of 6.5 ˚ C/km). Accordingly, GSTs showed negative surface offset (MAGST-MAAT) of -1.3 ˚ C and -1.5 ˚ C in 2014-2015 and 2015-2016, respectively. At the coldest sites, the surface offset regularly reached values well below -2 ˚ C and dropped up to -3.3 ˚ C. GSTs recorded prior to the onset of snow melting (i.e. BTS) averaged -3.8 ˚ C and -3.2 ˚ C in spring of 2015 and 2016, respectively, and varied between -5.8 ˚ C and -1.6 ˚ C. One-time BTS values showed the average of -2.8 ˚ C, but relatively high short-distance heterogeneity of BTS values, ranging between -8.3 ˚ C and 0.0 ˚ C, was encountered across the rock-glacier surfaces. The results suggest that permafrost occurrence is probable or possible in a total of ten rock glaciers, while its absence is probable only in one of the investigated landforms. We classify the latter form as relict and other two rock glaciers are suggested to be in inactive/relict state. Six rock glaciers are believed to be inactive and two even active/inactive. In most cases, however, permafrost likely occurs in a form of isolated patches or discontinuously and presumably degrades under present climate conditions.

  6. Genome-wide analysis of brain and gonad transcripts reveals changes of key sex reversal-related genes expression and signaling pathways in three stages of Monopterus albus

    Science.gov (United States)

    Hu, Qing; Guo, Wei; Li, Dapeng

    2017-01-01

    Background The natural sex reversal severely affects the sex ratio and thus decreases the productivity of the rice field eel (Monopterus albus). How to understand and manipulate this process is one of the major issues for the rice field eel stocking. So far the genomics and transcriptomics data available for this species are still scarce. Here we provide a comprehensive study of transcriptomes of brain and gonad tissue in three sex stages (female, intersex and male) from the rice field eel to investigate changes in transcriptional level during the sex reversal process. Results Approximately 195 thousand unigenes were generated and over 44.4 thousand were functionally annotated. Comparative study between stages provided multiple differentially expressed genes in brain and gonad tissue. Overall 4668 genes were found to be of unequal abundance between gonad tissues, far more than that of the brain tissues (59 genes). These genes were enriched in several different signaling pathways. A number of 231 genes were found with different levels in gonad in each stage, with several reproduction-related genes included. A total of 19 candidate genes that could be most related to sex reversal were screened out, part of these genes’ expression patterns were validated by RT-qPCR. The expression of spef2, maats1, spag6 and dmc1 were abundant in testis, but was barely detected in females, while the 17β-hsd12, zpsbp3, gal3 and foxn5 were only expressed in ovary. Conclusion This study investigated the complexity of brain and gonad transcriptomes in three sex stages of the rice field eel. Integrated analysis of different gene expression and changes in signaling pathways, such as PI3K-Akt pathway, provided crucial data for further study of sex transformation mechanisms. PMID:28319194

  7. Comet 67P/Churyumov-Gerasimenko, is the pristine material present anywhere close to the surface?

    Science.gov (United States)

    Kossacki, Konrad

    2016-10-01

    Observations of the nucleus of comet 67P/Churyumov-Gerasimenko indicate high complexity of the topography (Thomas et al., 2015). Presence of numerous pits, and depressions, as well as scarps suggests complex evolution of the nucleus. This in turn makes uncertain presence of the pristine material anywhere close to the surface. However, non-uniformity of the mechanical strength of the nucleus suggests, that in some locations material can retain initial structure. This should be expected neither in the final Philae landing site Abydos, where the compressive strength of the material is about 2 MPa (Spohn et al., 2015), neither in the location of the first touch down, where beneath a layer of unconsolidated material possibly is a hard material (Biele et al., 2015). Both locations are at low latitudes, where the flux of solar energy is much higher than northern parts of the lobes, illuminated when the comet is far form perihelion. Groussin et al. (2015) investigated what inclination of slopes corresponds to the presence of falling-out boulders and have found, that the average strength is probably lower than 1.5 kPa.I attempted to answer the question, whether in poorly illuminated regions of the nucleus of comet 67P/Churyumov-Gerasimenko are possible thermal conditions suitable for preservation of a pristine unconsolidated ice-dust material. For this purpose I calculated evolution of the temperature and structure of the material versus depth in selected locations in region Ma'at. This region is in general smooth (El-Maary et al., 2015), which may indicate presence of a loose dust mantle on the surface. The applied shape model is SHAP4s v1.0 (Preuskner et al., 2015). The performed simulations indicate, that in Scenario A preservation of low uni-axial compressive strength is possible, but only in shadowed locations, beneath a dust mantle of low thermal conductivity, at least few centimeters thick.

  8. Surface electromyographic evaluation of jaw muscles in children with unilateral crossbite and lateral shift in the early mixed dentition. Sexual dimorphism.

    Science.gov (United States)

    Lenguas, Leticia; Alarcón, José-Antonio; Venancio, Filipa; Kassem, Marta; Martín, Conchita

    2012-11-01

    To examine the activity of jaw muscles at rest and during maximal voluntary clenching (MVC) in children with unilateral posterior crossbite (UPXB) and functional lateral shift in the early mixed dentition and to evaluate sex differences. The sample included 30 children (15 males, 15 females) aged 6 to 10 years old, with UPXB and functional mandibular lateral shift (≥1.5 mm) in the early mixed dentition. sEMG activity coming from the muscle areas (anterior temporalis [AT], posterior temporalis [PT], masseter [MA] and suprahyoid [SH]) were obtained from both the crossbite (XB) and noncrossbite (NONXB) sides at mandibular rest position. sEMG activity of the bilateral AT and MA muscles sides was obtained during MVC. Asymmetry and activity indexes were calculated for each muscle area at rest and during MVC; the MA/TA ratio during MVC was also determined. At rest, no differences were found between sexes for any muscle areas or asymmetry and activity indexes. No differences were found between XB and NONXB sides. During MVC, however, significant sex differences were found in AT and MA activity, with higher sEMG values in males than in females, on both XB and NONXB sides. Asymmetry indexes, activity indexes and MA/AT ratios did not show significant differences between the sexes. Activity was symmetric both in males and in females. At rest, no sex differences were found, but during MVC males showed higher activity than did females in both XB and NONXB AT and MA muscle areas. Muscular activity was symmetrical at rest and during MVC in both sexes. Sexual dimorphism should be considered in the diagnosis and treatment of UPXB and lateral shift in the early mixed dentition.

  9. Adaptive thermal comfort explained by means of the Fanger-model; Adaptief thermisch comfort verklaard met Fanger-model

    Energy Technology Data Exchange (ETDEWEB)

    Van der Linden, W.; Loomans, M.G.L.C.; Hensen, J. [Technische Universiteit Eindhoven, Eindhoven (Netherlands)

    2008-07-15

    This article examines the relation between the adaptive thermal comfort (ATC) model and the Fanger model. The most important data collected were the value ranges of individual parameters in relation to ATC assessment. The ATC model uses a relatively simple indicator of thermal comfort. It treats the desired operational indoor temperature as a measure of thermal comfort in direct comparison to the outdoor temperature. This has the advantage of providing a relatively straightforward and transparent way of assessing occupant comfort. The Fanger model makes use of human thermal equilibrium, and is more flexible and more widely applicable. The results of the comparison show that, in a temperate climate like that of the Netherlands, the Fanger model is fully capable of explaining the results of the ATC model. [Dutch] In dit artikel is de relatie tussen het adaptief thermisch comfort (ATC) model en het Fanger-model nader onderzocht. Hierbij is vooral gekeken naar de ranges van waarden van de individuele parameters in relatie tot de ATC-beoordeling. Her ATC-model maakt gebruik van een minder complexe indicator om een uitspraak te doen over het thermisch comfort. Bij deze aanpak wordt de gewenste operatieve binnentemperatuur, als maat voor her thermisch comfort, direct gerelateerd aan de buitentemperatuur. Een voordeel hiervan is dat op een relatief eenvoudige en inzichtelijke manier een waardering van her comfort kan worden gegeven. Het Fanger-model maakt gebruik van de warmtebalans van de mens en is flexibeler en breder toepasbaar. De resultaten van de vergelijking laten zien dat voor een gematigd klimaat als in Nederland het Fanger-model goed in staat is om de resultaten van het ATC-model te verklaren.

  10. Can astronomy enhance UNESCO World Heritage recognition? The paradigm of 4th Dynasty Egyptian pyramids

    Science.gov (United States)

    Belmonte, Juan Antonio

    2015-08-01

    The pyramids of Egypt, notably those of the 4th Dinasty as Giza, have always be considered an unmistikable part of human world heritage as the only surviving wonders of the Ancient World. Their majesty, technical hability and innovative character have always beeen considered as representative of ancient Egyptian ingenuity. However, past and present fringe theories about the pyramids and astronomy have always polluted the role of our discipline in the design, construction and symbolism of these impressive monuments. This is indeed unfear. Fortunately, things have started to change in the last couple of decades and now astronomy is interpreted as a neccessary tool for the correct interpretation of the astral eschatology present in the 5th and 6th Dynasty Texts of the Pyramids. Although the pyramid complexes of the 4th Dynasty are mute, there is however recent research showing that a strong astral symbolism could be hidden in many aspects of the complex architecture and in the design of these exceptional monuments. This idea comes from several hints obtained not only from planning and construction, but also from epigraphy and the analysis of celestial and local landscapes. Chronology also plays a most relevant role on this. The pyramid complexes of the 4th Dynasty at Meidum, Dahshur, Giza and Abu Rowash -- all of which enjoy UNESCO World Heritage recognition -- willl be scrutinized. As a consequence, we will show how astronomy can certainly enhance the face value of these extraordinary monuments as a definitive proof of the ancient Egyptian quest for Ma'at, i.e. their perennial obsesion for Cosmic Order.

  11. Clinical and neurocognitive characterization of a family with a novel MED12 gene frameshift mutation.

    Science.gov (United States)

    Lesca, Gaetan; Moizard, Marie-Pierre; Bussy, Gerald; Boggio, Dominique; Hu, Hao; Haas, Stefan A; Ropers, Hans-Hilger; Kalscheuer, Vera M; Des Portes, Vincent; Labalme, Audrey; Sanlaville, Damien; Edery, Patrick; Raynaud, Martine; Lespinasse, James

    2013-12-01

    FG syndrome, Lujan syndrome, and Ohdo syndrome, the Maat-Kievit-Brunner type, have been described as distinct syndromes with overlapping non-specific features and different missense mutations of the MED12 gene have been reported in all of them. We report a family including 10 males and 1 female affected with profound non-specific intellectual disability (ID) which was linked to a 30-cM region extending from Xp11.21 (ALAS2) to Xq22.3 (COL4A5). Parallel sequencing of all X-chromosome exons identified a frameshift mutation (c.5898dupC) of MED12. Mutated mRNA was not affected by non-sense mediated RNA decay and induced an additional abnormal isoform due to activation of cryptic splice-sites in exon 41. Dysmorphic features common to most affected males were long narrow face, high forehead, flat malar area, high nasal bridge, and short philtrum. Language was absent or very limited. Most patients had a friendly personality. Cognitive impairment, varying from borderline to profound ID was similarly observed in seven heterozygous females. There was no correlation between cognitive function and X-chromosome inactivation profiles in blood cells. The severe degree of ID in male patients, as well as variable cognitive impairment in heterozygous females suggests that the duplication observed in the present family may have a more severe effect on MED12 function than missense mutations. In a cognitively impaired male from this family, who also presented with tall stature and dysmorphism and did not have the MED12 mutation, a 600-kb duplication at 17p13.3 including the YWHAE gene, was found in a mosaic state.

  12. Transport of branched tetraether lipids from the Tagus River basin to the coastal ocean of the Portuguese margin: consequences for the interpretation of the MBT'/CBT paleothermometer

    Science.gov (United States)

    Zell, C.; Kim, J.-H.; Balsinha, M.; Dorhout, D.; Fernandes, C.; Baas, M.; Sinninghe Damsté, J. S.

    2014-10-01

    Branched glycerol dialkyl glycerol tetraethers (brGDGTs), which are thought to be transported from soil to marine sediment by rivers, have been used to reconstruct the mean annual air temperature (MAAT) and soil pH of the drainage basin using the methylation index of branched tetraethers (MBT, recently refined as MBT') and cyclization index of branched tetraethers (CBT) from coastal marine sediment records. In this study, we trace the brGDGTs from source to sink in the Tagus River basin, the longest river system on the Iberian Peninsula, by determining their concentration and distribution in soils, river suspended particulate matter (SPM), riverbank sediments, marine SPM, and marine surface sediments. The concentrations of brGDGTs in river SPM were substantially higher and their distributions were different compared to those of the drainage basin soils. This indicates that brGDGTs are mainly produced in the river itself. In the marine environment, the brGDGT concentrations rapidly decreased with increasing distance from the Tagus estuary. At the same time, the brGDGT distributions in marine sediments also changed, indicating that marine in situ production also takes place. These results show that there are various problems that complicate the use of the MBT'/CBT for paleoreconstructions using coastal marine sediments in the vicinity of a river. However, if the majority of brGDGTs are produced in the river, it might be possible to reconstruct the environmental (temperature and pH) conditions of the river water using appropriate aquatic calibrations, provided that marine core locations are chosen in such a way that the brGDGTs in their sediments are predominantly derived from riverine in situ production.

  13. Scenario-based climate change modelling for a regional permafrost probability model of the southern Yukon and northern British Columbia, Canada

    Directory of Open Access Journals (Sweden)

    P. P. Bonnaventure

    2012-10-01

    Full Text Available Scenario-based climate change modelling for equilibrium conditions was applied to a Regional Model of permafrost probability for the southern Yukon and northwestern British Columbia. Under a −1 K cooling scenario, permafrost area expands from 58% (present day of the 490 000 km2 to 76%, whereas warming scenarios of +1 K, +2 K and +5 K decrease the terrain underlain by permafrost to 38%, 24% and 9% respectively. The morphology of permafrost gain/loss under these scenarios is controlled by the Surface Lapse Rate (SLR, which varies across the region below and above treeline. The SLR is an air temperature elevation gradient that that is noticeably different across the study region. As a result of this attribute three distinct patterns of loss morphology can be identified. Areas that are more maritime exhibit SLRs characteristically similar above and below treeline resulting in low probabilities of permafrost in valley bottoms. Consequently, a loss front moves to upper elevations when warming scenarios are applied (Simple Unidirectional Spatial Loss. Areas where SLRs are gentle below treeline (but normal/negative and normal above treeline show lower permafrost probabilities with a loss front moving up mountain according to two separate SLRs (Complex Unidirectional Spatial Loss. Finally areas that display high continentally exhibit Bidirectional Spatial Loss where the loss front of lower permafrost probabilities moves up mountain above treeline and down mountain below treeline. Areas that are most affected by permafrost loss are zones with SLRs close to 0 K km−1 where permafrost is extensive, whereas the least susceptible areas to changes in MAAT are above treeline and are highly elevation dependent.

  14. A novel approach to quickly differential diagnose the macro-reentrant mitral annular atrial tachycardia with left appendage potentials%结合左心耳电位快速鉴别二尖瓣环折返性房性心动过速

    Institute of Scientific and Technical Information of China (English)

    施海峰; 刘旭; 王新华; 谭红伟; 姜伟峰; 周立; 顾佳宁; 王远龙; 杨国澍; 刘玉岗

    2011-01-01

    目的 探讨结合左心耳电位快速鉴别二尖瓣环折返性房性心动过速(房速)的临床应用价值.方法 连续348例心房颤动(房颤)导管消融患者中发生大折返房速时,将环状标测电极置于左心耳内,消融导管置于左心房前壁,根据冠状静脉窦、左心耳和左心房前壁电位的激动模式初步判断大折返房速的机制,然后在Carto系统指导下进行激动标测和拖带标测明确折返机制,评价结合左心耳和冠状静脉窦电位快速鉴别诊断二尖瓣环折返的准确性和特异性.结果 40例房颤患者消融过程中共发生经Carto系统激动标测及拖带验证明确诊断的53种大折返房速,其中24种二尖瓣折返、19种三尖瓣折返和10种房顶依赖的折返.24种二尖瓣折返中,8种为冠状静脉窦近端领先的逆钟向折返,均表现为冠状静脉窦近端-中间-远端-左心耳(CSP-CSM-CSD-LAA)的激动模式,16种是冠状静脉窦远端领先的顺钟向折返,均表现为左心耳-冠状静脉窦远端-中间-近端(LAA-CSD-CSM-CSP)的激动模式.与Carto指导的激动标测和拖带标测出的折返环相比,用CSP-CSM-CSD-LAA或LAA-CSD-CSM-CSP的激动模式判断二尖瓣折返性房速总体敏感性100%,特异性75%,结合左心房前壁电位可进一步提高诊断特异性.结论 结合左心耳电位的快速标测是鉴别二尖瓣环折返性房速的有效方法.%Objective To investigate the feasibility and efficacy of quick mapping by analyzing the left atrial appendage (LAA)potentials to categorize two types of macro-reentrant mitral annular atrial tachycardia (MAAT).Methods Three hundred forty-eight consecutive patients with atrial fibrillation (AF)underwent catheter ablation were enrolled.When macro-reentrant AT occurred,the circular electrodes were placed into LAA to record the changing of activation sequence during mapping and ablating.Simultaneously,the activation sequence mapping guided by Carto system and entrainment

  15. South Dakota NASA Space Grant Consortium Creating Bridges in Indian Country

    Science.gov (United States)

    Bolman, J. R.

    2004-12-01

    The South Dakota Space Grant Consortium (SDSGC) was established March 1, 1991 by a NASA Capability Enhancement Grant. Since that time SDSGC has worked to provide earth and space science educational outreach to all students across South Dakota. South Dakota has nine tribes and five tribal colleges. This has presented a tremendous opportunity to develop sustainable equitable partnerships and collaborations. SDSGC believes strongly in developing programs and activities that highlight the balance of indigenous science and ways of knowing with current findings in contemporary science. This blending of science and culture creates a learning community where individuals, especially students, can gain confidence and pride in their unique skills and abilities. Universities are also witnessing the accomplishments and achievements of students who are able to experience a tribal college environment and then carry that experience to a college/university/workplace and significantly increase the learning achievement of all. The presentation will highlight current Tribal College partnerships with Sinte Gleska University and Oglala Lakota College amongst others. Programs and activities to be explained during the presentation include: Native Connections, Scientific Knowledge for Indian Learning and Leadership (SKILL), Bridges to Success Summer Research Program, Fire Ecology Summer Experience, and dual enrolled/college bridge programs. The presentation will also cover the current initiatives underway through NASA Workforce Development. These include: partnering program with the Annual He Sapa Wacipi, American Indian Space Days 2005, NASA research/internship programs and NASA Fellow Summit. An overview of recent American Indian student success will conclude the presentation. The South Dakota School of Mines and Technology has struggled over many years to develop and implement sustainable successful initiatives with Tribal Colleges and Communities. The motivating philosophy is the

  16. Development of a real-time fluorescent quantitative PCR for detection of Campylobacter fetus%胎儿弯杆菌病TaqMan实时荧光定量PCR检测方法的建立

    Institute of Scientific and Technical Information of China (English)

    赵海玲; 刘慧芳; 杜艳芬; 司微; 王春来; 刘思国

    2009-01-01

    A real-time fluorescent quantitative PCR was developed for the detection of Campylobacter fetus using a pair of primers and a TaqMan probe specific to the SapA gene of Campylobacter fetus. The assay is highly specific and showed no cross reactivity against other bacteria. It had a sensitivity of detecting 13 copies of bacterial DNA. This method was rapid, highly sensitive and specific. The assay could provide a powerful tool for quantification of Campylobacter fetus, and could be further developed into a commercial kit for rapid detection of Campylobacter fetus.%为建立胎儿弯杆菌(C.fetus)定量检测方法,本研究根据C.fetus毒力因子表面蛋白(SapA)基因序列设计引物和一条特异的TaqMan水解探针,建立了一种敏感、特异、重复性好的快速检测C.fetus的TaqMan荧光定量PCR方法.对该方法的特异性与敏感性研究,结果显示,该方法检测C.fetus结果均为阳性,而非C.fetus均为阴性;对带有SapA基因的阳性质粒的检测敏感性为10~8拷贝~10~2拷贝/μL范围内具有良好的线性关系,可敏感地检测到模板中13个拷贝的细菌DNA,其灵敏度是常规PCR方法的100倍.该方法具有简便、快速、特异性强、敏感性高等特点.该方法为C.fetus快速检测试剂盒的研制打下了良好的基础.

  17. Lateral flow immunoassay for diagnosis of Trypanosoma cruzi infection with high correlation to the radioimmunoprecipitation assay.

    Science.gov (United States)

    Houghton, Raymond L; Stevens, Yvonne Y; Hjerrild, Kathryn; Guderian, Jeff; Okamoto, Masahiko; Kabir, Mazbahul; Reed, Steven G; Leiby, David A; Morrow, W John W; Lorca, Myriam; Raychaudhuri, Syamal

    2009-04-01

    The incidence of blood donors seropositive for Trypanosoma cruzi in North America has increased with population migration and more rigorous surveillance. The United States, considered nonendemic for T. cruzi, could therefore be at risk to exposure to parasite transmission through blood or organ donations. Current tests show variable reactivity, especially with Central American sera. Here we describe the development of a lateral flow immunoassay for the rapid detection of T. cruzi infection that has a strong correlation to the radioimmunoprecipitation assay (RIPA) "gold standard" in the United States. Such a test could have utility in small blood banks for prescreening donors, as well as in cardiac transplantation evaluation. T. cruzi consensus and/or RIPA-positive sera from Central and South America were evaluated in enzyme immunoassays (EIAs). These included commercial panels from Boston Biomedica, Inc. (BBI) (n = 14), and HemaBio (n = 21). Other sources included RIPA-positive sera from the American Red Cross (ARC) (n = 42), as well as from Chile. Sera were tested with the multiepitope recombinant TcF. All but one of the BBI samples were positive and 7 of 21 HemaBio samples and 6 of 42 ARC samples were low positive or negative. This observation indicated the need for additional antigens. To complement TcF reactivity, we tested the sera with peptides 30, 36, SAPA, and 1.1, 1.2, and 1.3 His fragments of 85-kDa trans-sialidase. We identified a promising combination of the tested antigens and constructed a single recombinant protein, ITC6, that enhanced the relative sensitivity in U.S. blood donor sera compared to that of TcF. The data on its evaluation using RIPA-confirmed positive sera in EIA and lateral flow immunoassay studies are presented, along with an additional recombinant protein, ITC8.2, with two additional sequences for peptide 1 and Kmp-11. The latter, when evaluated in a dipstick assay with consensus positive sera, had a sensitivity of 99.2% and a

  18. Native Geosciences: Strengthening the Future Through Tribal Traditions

    Science.gov (United States)

    Bolman, J. R.; Quigley, I.; Douville, V.; Hollow Horn Bear, D.

    2008-12-01

    communities and a return to traditional ways of supporting the development of our "story" or purpose for being. The opportunities include residential summer field experiences, interdisciplinary curriculums and development of Tribally-driven Native research experiences. The National Science Foundation, University of North Dakota's Northern Great Plains Center for People and the Environment, Upper Midwest Aerospace Consortium (UMAC), and Tribes have provided funding to support the development of Native geosciences. The presentation will focus on current projects: NSF OEDG "He Sapa Bloketu Woecun; Geosciences at the Heart of Everything That Is", NSF S-STEM "Scientific Leadership Scholars" and the NSF BPC "Coalition of American Indians in Computing". The expressed goal of future initiatives is to connect Tribal communities across the Midwest and West in developing a Native Geosciences Pathway. This pathway supports the identification and support of Tribal students with an interest or "story" connected to geosciences ensuring a future Native geosciences workforce.

  19. Estimates of tracer-based piston-flow ages of groundwater from selected sites: National Water-Quality Assessment Program, 2006-2010

    Science.gov (United States)

    Shapiro, Stephanie D.; Plummer, L. Niel; Busenberg, Eurybiades; Widman, Peggy K.; Casile, Gerolamo C.; Wayland, Julian E.; Runkle, Donna L.

    2012-01-01

    Piston-flow age dates were interpreted from measured concentrations of environmental tracers from 812 National Water-Quality Assessment (NAWQA) Program groundwater sites from 27 Study Units across the United States. The tracers of interest include chlorofluorocarbons (CFCs), sulfur hexafluoride (SF6), and tritium/helium-3 (3H/3He). Tracer data compiled for this analysis were collected from 2006 to 2010 from groundwater wells in NAWQA studies, including: * Land-Use Studies (LUS, shallow wells, usually monitoring wells, located in recharge areas under dominant land-use settings), * Major-Aquifer Studies (MAS, wells, usually domestic supply wells, located in principal aquifers and representing the shallow drinking water supply), * Flow System Studies (FSS, networks of clustered wells located along a flowpath extending from a recharge zone to a discharge zone, preferably a shallow stream) associated with Land-Use Studies, and * Reference wells (wells representing groundwater minimally impacted by anthropogenic activities) also associated with Land-Use Studies. Tracer data were evaluated using documented methods and are presented as aqueous concentrations, equivalent atmospheric concentrations (for CFCs and SF6), and tracer-based piston-flow ages. Selected ancillary data, such as redox data, well-construction data, and major dissolved-gas (N2, O2, Ar, CH4, and CO2) data, also are presented. Recharge temperature was inferred using climate data (approximated by mean annual air temperature plus 1°C [MAAT +1°C]) as well as major dissolved-gas data (N2-Ar-based) where available. The N2-Ar-based temperatures showed significantly more variation than the climate-based data, as well as the effects of denitrification and degassing resulting from reducing conditions. The N2-Ar-based temperatures were colder than the climate-based temperatures in networks where recharge was limited to the winter months when evapotranspiration was reduced. The tracer-based piston-flow ages

  20. Influences of Climate Warming and Facility Management on Continuous Permafrost at Matterhorn Glacier Paradise, Zermatt, Swiss Alps.

    Science.gov (United States)

    King, Lorenz; Duishonakunov, Murataly; Imbery, Stephan

    2014-05-01

    In many parts of the Alps, hazardous bedrock instabilities occur more often during the past 30 years. In many cases, permafrost degradation played a central role for instability (e.g. in 1987 the Val Pola rockslide, Italy). At other events, the role of permafrost degradation is more complex or unpredictable (e.g. in 1991 the Randa rockfall, Wallis, Swiss Alps). However, instabilities in perennially frozen bedrock may also be provoked by human influence. This is exemplarily shown at touristic facilities in the Alps. Human impact on permafrost is often underestimated, or even carelessly taken into account. The tourist resort Zermatt with more than 1.8 million overnight stays per year is located at 1600 m a.s.l. and is surrounded by high mountain ranges that often reach above 4000 m. The dry and sunny climate results in a high glacier equilibrium line thus leaving space for vast non-glaciated permafrost terrain. Numerous tourist facilities provide excellent logistics and easy access to permafrost sites, and the region is thus especially suitable for permafrost research. The infrastructure erected on permafrost consists of hotels, restaurants and mountain huts, station buildings of railways, funiculars, ski lifts and installations for artificial snowing the ski-runs. Some problems at these constructions due to permafrost degradation are shown. At the Matterhorn Glacier Paradise station at an altitude of 3820 meters, todays MAAT ranges between -6 °C and -8°C. During the construction of a tunnel in 1981 bedrock temperatures were at -12°C. Over the past 30 years, these bedrock temperatures have risen to -3 to -2°C, due to the heat brought into the tunnel by facilities and more than 490,000 visitors per year. In an elevator shaft, the temperature temporarily even rose above freezing point. Several new construction sites in continuous permafrost are described and new research data is presented. Another interesting site for permafrost and ice studies at Matterhorn

  1. The Relationship Between Personality Traits and Learning Motivation of Freshmen in High School%高一新生人格特质与学习动机的关系

    Institute of Scientific and Technical Information of China (English)

    范红梅; 李雪平

    2016-01-01

    The study was conducted by Eysenck's Personalit y Questionnaire (EPQ)revised edition and Zhou Bucheng revised Motivation and Achievement Test (MAAT). It tested 1750 senior freshmen to explore status of their personality and learning motivation and relationships between them,and the results indicated Male and female students were quite different in the oriented external target of learning motivation,learning value,self-efficacy and expectation for success. Male and female students' scores were not significantly dif-ferent in the P dimension and E dimension,and quite different in N dimension and L dimension; introvert and extrovert personality,the neuroticism and anxiety test showed negative correlation; psychoticism and the overall motivation showed significantly negative correlation;several dimensions of learning motivation were significantly correlated;and personality characteristics were closely related to learning motivation.%采用艾森克的人格问卷(EPQ)的修订版与周步成修订的学习动机诊断测验(MAAT)对1750名高一学生进行测试,旨在探讨高一新生人格与学习动机的状况及其关系,结果表明:男女生在学习动机的外在目标导向、学习价值、自我效能、期望成功上差异显著;男女学生在P维度、E维度得分差异不显著,在N维度、L维度上得分差异显著;内外向、神经质与测试焦虑呈显著负相关;精神质与整体动机呈显著负相关;学习动机的几个维度间均呈显著相关性;人格特质与学习动机呈显著性相关。

  2. Uwarunkowania zaburzeń poznawczych powstających wskutek leczenia onkologicznego i wybrane sposoby terapii kognitywnej

    Directory of Open Access Journals (Sweden)

    Magdalena Bury

    2015-04-01

    Full Text Available Jak wynika z aktualnych danych empirycznych, sytuację pacjenta cierpiącego na nowotwór mogą dodatkowo utrudniać współwystępujące zaburzenia poznawcze pojawiające się wskutek leczenia onkologicznego; zaburzenia te określa się jako chemobrain. Rezultaty badań są bardzo zróżnicowane – zarówno w zakresie powszechności zaburzeń poznawczych, ich nasilenia czy czasu trwania, jak i w zakresie czynników determinujących lub modyfikujących objawy dotyczące procesów poznawczych. Do mechanizmów bezpośrednio wpływających nawystąpienie zaburzeń poznawczych zalicza się czynniki neurotoksyczne, stres oksydacyjny, uszkodzenie DNA, zmiany hormonalne, dysregulację immunologiczną, zmiany naczyniowe ośrodkowego układu nerwowego, predyspozycje genetyczne. Pośrednio na powstawanie zaburzeń oddziałują natomiast mutacje genetyczne, cytokiny prozapalne, zespoły paranowotworowe, rodzaj leczenia, polimorfizm genetyczny, reaktywność immunologiczna, dieta, poziom hormonów i wcześniejsze zasoby poznawcze chorego. Celem artykułu jest analiza wyników badań wyjaśniających zróżnicowane skutki poznawcze leczenia onkologicznego, ze szczególnym uwzględnieniem dysregulacji poziomu cytokin – mającej, jak się wydaje, istotny udział wpatogenezie objawów chemobrain. Omówiono także kilka podejść terapeutycznych wspomagających codzienne funkcjonowanie poznawcze pacjentów onkologicznych: trening MAAT (Memory and Attention Adaptation Training, metodę CBMEM (Cognitive-Behavioral Model of Everyday Memory, ćwiczenia C-Car and Strategy Training, metodę redukcji stresu MSBR (Mindfulness-Based Stress Reduction i polski system RehaCom. Wszystkie wymienione propozycje mają na celu usprawnianie wybranych funkcji, takich jak uwaga albo pamięć, wzrost samoświadomości deficytów i poprawę samokontroli.

  3. From the Editors – Redactioneel

    Directory of Open Access Journals (Sweden)

    Catrien Santing

    2015-12-01

    Full Text Available Sometimes an issue grows naturally into a theme number. The occasion was the celebration of two hundred years of the Kingdom of the Netherlands, which is almost over. BMGN – Low Countries Historical Review has put the most important publications that emerged in connection with this milestone into a historiographical context and judged them on their merits and blind spots. In the forum ‘The Bicentennial 1813-1815’ James Kennedy, Gita Deneckere, Matthijs Lok and Alicia Schrikker take an historiographical approach and tackle the various commemorative works from the point of view of such questions as continuitydiscontinuity of the Ancien Régime in the Netherlands/Belgium 1813-1831, the national history writing about this period in the Netherlands and Belgium and the situation in the colonies, something often forgotten. Tom Verschaffel succesfully reviews three royal biographies within a single framework and points out the similarities and differences between the three. The perceptive analyses of all these monumental works to which the occasion has given rise appear to accord well with other royal material, which indicates that this is a vigorous field of research. Frans Willem Lantink demonstrates this in his dissection of the usual genres dealing with the subject. Susie Protschky extends the area of royalty research to the Netherlands-Indies. She makes clear the role played by photographs in establishing the ‘imagined community’ of royalists who were faithful to the Dutch fatherland and Queen Wilhelmina.In the discussion dossier on historical reasoning Dick de Boer, Peter Henderikx, Roos van Oosten and Erik Cordfunke and George Maat discuss the importance of innovative methods borrowed from physics and technology, in trying to solve tricky historical questions, but eventhis debate has a royal tinge. The protagonist, or perhaps it would be better to speak of the subject because it is about his remains, is the Dutch Count William II

  4. Episodic speleothem deposition tracks the terrestrial impact of millennial-scale last glacial climate variability in SW Ireland

    Science.gov (United States)

    Fankhauser, Adelheid; McDermott, Frank; Fleitmann, Dominik

    2016-11-01

    Eighty four new U-Th ages are presented for twenty randomly selected broken, displaced and reworked calcite speleothems retrieved from clastic sedimentary fill and from isolated bedding-plane shelves in Crag cave (SW Ireland). The dated pre-Holocene samples span much of the last glacial, ranging in age from 85.15 ± 0.60 to 23.45 ± 0.17 ka. Speleothem deposition requires the presence of liquid water, and because Crag cave is a shallow system, deposition is considered likely only when mean annual air temperatures (MAAT) exceed the freezing point of water. Deposition at this mid-latitude ocean-marginal site occurred episodically during MIS5a through to MIS2, synchronously within dating uncertainties, with the timing of Greenland Interstadials (GI). In the latter part of Marine Isotope Stage 3 (MIS3), deposition was particularly intense, consistent with regional scale climate amelioration inferred previously from radiocarbon ages for sparse MIS3 organic and freshwater surficial deposits in N. Ireland. A brief episode of speleothem deposition at c.23.40 ± 0.22 ka coincides with GI-2, demonstrating the sensitivity of the site to brief climate amelioration episodes in Greenland during MIS2. Conditions favourable for speleothem deposition occurred periodically during the last glacial, indicating temperature changes of at least 10 °C between stadials and interstadials at this mid-latitude site. Deposition ceased during Greenland Stadials (GS), including during periods of ice-rafting in the adjacent N. Atlantic Ocean (Heinrich events). Oxygen and carbon isotope ratios of the last glacial speleothems are generally elevated, reflecting non-equilibrium isotope fractionation effects. However, establishment of low δ13C values often occurred within a few decades of climate amelioration, indicating that biogenic CO2 production resumed rapidly at this site, particularly during MIS3. Speleothem δ18O variability was driven largely by long-term changes in the δ18O value of the

  5. Identification, characteristics and classification of cryogenic block streams

    Institute of Scientific and Technical Information of China (English)

    Stuart A. Harris

    2016-01-01

    ABSTRACT Cryogenic block streams consist of a stream of rocks superficially resembling a stream deposit but lacking a matrix, usually occurring on a valley or gully floor or on slopes that are less steep than the maximum angle of repose of coarse sediments. They are usually formed on perennially frozen ground, but can also occur as relict landforms. There are three main active kinds forming today,viz., Siberian and Tibetan dynamic rock streams and lag block streams. During their formation, the blocks in the active Siberian and Tibetan dynamic block streams move downslope at up to 1 m/a. They are forming today on the Tibetan Plateau and in the more arid parts of south-central Siberia, although the processes involved in the movement are different. In the case of the Tibetan type, individual blocks slide downslope over the substrate in winter on an icy coating in areas of minimal winter precipitation. The Siberian type develops in areas of 15–80 cm of winter snow cover and an MAAT (mean annual air temperature) of−4 °C to−17 °C. The movement is due to creep of snow and ice and collapse of the blocks downslope during thawing. Lag block streams are formed by meltwater flowing over the surface of sediment consisting primarily of larger blocks with a limited amount of interstitial sediment. The erosion of the matrix is primarily in the spring in areas of higher winter precipitation on 10°–30° slopes. The blocks remain stationary, but the interstitial sediment is washed out by strong seasonal flows of meltwater or rain to form an alluvial fan. The boulders undergo weathering and become more rounded in the process. Lag block streams can also develop without the presence of permafrost in areas with cold climates or glaciers. Block streams also occur as relict deposits in older deposits under various climatic regimes that are unsuitable for their formation today. An example of relict lag block streams with subangular to subrounded blocks occurs in gullies on the

  6. The Response Model of Permafrost along the Qinghai-Tibetan Highway under Climate Change%全球气候变化下青藏公路沿线冻土变化 响应模型的研究

    Institute of Scientific and Technical Information of China (English)

    李新; 李文君; 吴青柏

    2001-01-01

    GCM model HADCM2, which was developed in the Hadley Center for Climate Prediction and Research in Britain, was adopted for climate scenarios. Only air temperature scenarios in permafrost response model are used. In order to preserve the original air temperature forecast results in the HADCM2; the nearest-neighbor method was used to resample the air temperature for the years 2009, 2049 and 2099 into 0.5°×0.5°grids compatible with the DEM. The predication shows that the mean raising of air temperature will be 0.46 ℃ in 2009, 0.78 ℃ in 2049 and 2. 53 ℃2 in 2099 from 36° to 33.5° N, and 0. 72 ℃ in 2009, 0.78 ℃ in 2049 and 2. 68 ℃ in 2099 from 33.5° to 31° N. Altitude model, which was proposed for the permafrost distribution limit in Northern Hemisphere, is used to determine the permafrost distribution limit (Equation 1). Permafrost zone model, which is proposed by the multiple linear regression relationships among MGATs, altitude and latitude, is used to determine the permafrost zone distribution (Equation 2). The altitude model does not contain climate variables, such as air temperature. Thus, the relationship between predicted air temperature change AT of HADCM2 and permafrost lower limit uplifting AH is established as Equation 3. The relationship between the MAGTs and MAATs can be established as Equation 4. And assuming that rising air temperature would result in immediate permafrost warming. The rising MAATs at lower limit will result in changing MAGTs of permafrost zones. The response model of permafrost zone is proposed on the Equations (3) and (5): Under the support of GIS, the response model of permafrost zone and the DTM along the Qinghai -Tibetan Highway, the permafrost change of the highway are obtained under GCM climate scenario in 2009, 2049, and 2099. The results show that permafrost zone will greatly change after climate warming. Their area is expected to decrease and permafrost zone will be moving upward and degrading. In order to

  7. Integrating geoscience and Native American experiences through a multi-state geoscience field trip for high school students

    Science.gov (United States)

    Kelso, P. R.; Brown, L. M.; Spencer, M.; Sabatine, S.; Goetz, E. R.

    2012-12-01

    Lake Superior State University (LSSU) developed the GRANITE (Geological Reasoning And Natives Investigating The Earth) to engage high school students in the geosciences. The GRANITE program's target audience is Native American high school students and other populations underrepresented in the geosciences. Through the GRANITE program students undertake a variety of field and laboratory geosciences activities that culminates in a two week summer geoscience field experience during which they travel from Michigan to Wyoming. The sites students visit were selected because of their interesting and diverse geologic features and because in many cases they have special significance to Native American communities. Examples of the processes and localities studied by GRANITE students include igneous processes at Bear Butte, SD (Mato Paha) and Devil's Tower, WY (Mato Tipila); sedimentary processes in the Badlands, SD (Mako Sica) and Black Hills, SD (Paha Sapa); karst processes at Wind Cave, SD (Wasun Niye) and Vore Buffalo Jump; structural processes at Van Hise rock, WI and Dillon normal fault Badlands, SD; hydrologic and laucustrine processes along the Great Lakes and at the Fond du Lac Reservation, MN; fluvial processes along the Mississippi and Missouri rivers; geologic resources at the Homestake Mine, SD and Champion Mine, MI; and metamorphic processes at Pipestone, MN and Baraboo, WI. Through the GRANITE experience students develop an understanding of how geoscience is an important part of their lives, their communities and the world around them. The GRANITE program also promotes each student's growth and confidence to attend college and stresses the importance of taking challenging math and science courses in high school. Geoscience career opportunities are discussed at specific geologic localities and through general discussions. GRANITE students learn geosciences concepts and their application to Native communities and society in general through activities and

  8. South Dakota Space Grant Consortium: Balancing Indigenous Earth System and Space Science with Western/Contemporary Science

    Science.gov (United States)

    Bolman, J.; Nall, J.

    2005-05-01

    The South Dakota Space Grant Consortium (SDSGC) was established March 1, 1991 by a NASA Capability Enhancement Grant. Since that time SDSGC has worked to provide earth system and space science education, outreach and services to all students across South Dakota. South Dakota has nine tribes and five Tribal Colleges. This has presented a tremendous opportunity to develop sustainable equitable partnerships and collaborations. SDSGC believes strongly in developing programs and activities that highlight and reinforce the balance of Indigenous science and ways of knowing with current findings in Western/Contemporary Science. This blending of science and culture creates a learning community where individuals especially students, can gain confidence and pride in their unique skills and abilities. Universities are also witnessing the accomplishments and achievements of students who are able to experience a tribal environment and then carry that experience to a college/university/workplace and significantly increase the learning achievement of all. The presentation will highlight current Tribal College and Tribal Community partnerships with the Rosebud Sioux Reservation (Sinte Gleska University), Pine Ridge Indian Reservation (Oglala Lakota College), Standing Rock Sioux Reservation (Sitting Bull College) and Cheyenne River Sioux Reservation (Si Tanka) amongst others. Programs and activities to be explained during the presentation include but not limited to: NASA Workforce Native Connections, Scientific Knowledge for Indian Learning and Leadership (SKILL), NSF "Bridges to Success" Summer Research Program, NSF "Fire Ecology" Summer Research Experience, as well as geospatial and space science programs for students and general community members. The presentation will also cover the current initiatives underway through NASA Workforce Development. These include: partnering with the Annual He Sapa Wacipi (Black Hills Pow Wow - attendance of 14,000 Natives) to host Native Space

  9. How robust is a robust policy? A comparative analysis of alternative robustness metrics for supporting robust decision analysis.

    Science.gov (United States)

    Kwakkel, Jan; Haasnoot, Marjolijn

    2015-04-01

    performance of a candidate plan with the performance of other candidate plans across a large ensemble of plausible futures. Initial results suggest that the simplest satisficing metric, inspired by the signal to noise ratio, results in very risk averse solutions. Other satisficing metrics, which handle the average performance and the dispersion around the average separately, provide substantial additional insights into the trade off between the average performance, and the dispersion around this average. In contrast, the regret-based metrics enhance insight into the relative merits of candidate plans, while being less clear on the average performance or the dispersion around this performance. These results suggest that it is beneficial to use multiple robustness metrics when doing a robust decision analysis study. Haasnoot, M., J. H. Kwakkel, W. E. Walker and J. Ter Maat (2013). "Dynamic Adaptive Policy Pathways: A New Method for Crafting Robust Decisions for a Deeply Uncertain World." Global Environmental Change 23(2): 485-498. Kwakkel, J. H., M. Haasnoot and W. E. Walker (2014). "Developing Dynamic Adaptive Policy Pathways: A computer-assisted approach for developing adaptive strategies for a deeply uncertain world." Climatic Change.

  10. Three Years of High Resolution Year-Round Monitoring of Ice-Wedge Thermal Contraction Cracking in Svalbard

    Science.gov (United States)

    Christiansen, H. H.

    2006-12-01

    Most likely ice-wedges are the most widespread periglacial landform in lowlands with continuous permafrost. With a changing climate it is important to understand better the geomorphological processes controlling ice- wedge growth and decay, as they might cause large changes to the surface of the landscape, particularly if the active layer thickness increases causing melting of the most ice-rich permafrost top layer. As most settlements on permafrost are located in lowland areas, ice-wedge formation can also influence the infrastructure. Understanding the processes of ice-wedge growth and their thaw transformation into ice-wedge casts are essential when using contemporary ice wedges as analogues of Pleistocene thermal contraction cracking in palaeoenvironmental reconstructions. As ice-wedges are largely controlled by winter conditions, improved understanding of the factors controlling their growth will enable better palaeoclimatic reconstructions both directly from ice-wedges, but also from ice-wedge casts, than just mean winter temperatures. Detailed studies of ice-wedge dynamics, including quantification of movement, have only been done in very few places in the Arctic. In high arctic Svalbard at 78°N climate at sea level locates these islands close to the southern limit of the continuous permafrost zone, with MAAT of as much as -4 to -6°C. However, thermal contraction cracking is demonstrated to be widespread in the Adventdalen study area in Svalbard. The year-round field access from the University Centre in Svalbard, UNIS, has enabled the collection of different continuous or high frequency ice-wedge process monitoring data since 2002 to improve the understanding of the geomorphological activity of this landform. In all the winters the air temperature was below -30°C for shorter or longer periods. During all the winters, the temperature in the top permafrost was below -15°C both in the ice-wedge top for shorter or longer periods. The snow cover was

  11. The Correlation Between High School Freshmen's Learning Motivation and Mental Health:A Case Study of the Senior High Schools in Nanchong%高一新生学习动机与心理健康的关系--以南充市高中为例

    Institute of Scientific and Technical Information of China (English)

    范红梅; 李雪平

    2016-01-01

    为了探究高一新生学习动机及其心理健康状况的关系,采用周步成修订的学习动机诊断测验(MAAT)和安人集团编制的中小学生心理健康测试对1750名高一学生进行测试。研究结果表明:高一新生的心理问题主要表现在消极、适应性、自我悦纳、交往障碍、恐怖倾向和自卑倾向;高一女生比男生更容易消极自卑、焦虑、适应新环境,男生较女生更自信和认可自己;拥有积极心态的学生学习动机更强,考试焦虑感越低;高一新生适应性与学习动机显著正相关;自我悦纳、自信心越强、自我肯定的人学习动机越强,考试焦虑感越低;自卑、人际交往问题与学习价值感、自我效能感、期望成功等呈显著负相关;自我悦纳与学习动机及各维度显著相关,与考试焦虑呈显著负相关;高一新生学习动机与心理健康相关性显著。%The present thesis purports to study the correlation between high school freshmen's learning motivation and mental health by testing 1750 high school freshmen with MAAT which was revised by Zhou Bucheng and the primary and middle school students' mental health test made by Anren Company. The results of the tests show that high school freshmen's major mental problems lie in poor adaptability, poor self-acceptability, being negative, fearful, unconfident and having communication problems. The girls are more likely to be unconfident, anxious and adaptable, while the boys are more confident than the girls and have higher self-acceptability. The students with positive attitudes have stronger learning motivation and less anxiety for tests. Besides, there is a positive correlation between high school freshmen's adaptability and learning motivation: the students who are more self-acceptable, confident tend to have stronger learning motivation and less anxiety for tests. And there is a negative correlation between being unconfident, having

  12. Combination of branched GDGTs and testate amoebae for the reconstruction of past climate change in a French peatland

    Science.gov (United States)

    Huguet, Arnaud; Jassey, Vincent E. J.; Laggoun-Défarge, Fatima; Derenne, Sylvie; Gilbert, Daniel; Delarue, Frédéric; Payne, Richard; Buttler, Alexandre; Mitchell, Edward A. D.

    2013-04-01

    Peatlands are important archives for the reconstruction of past environmental changes because of their high rates of peat accumulation due to the low rate of plant litter decomposition. Branched glycerol dialkyl glycerol tetraethers (GDGTs) are complex lipids of high molecular weight, recently discovered in soils and suggested to be produced by anaerobic bacteria. The relative distribution of branched GDGTs in soils correlates with environmental variables: the degree of methylation, expressed in the methylation index of branched tetraethers (MBT), depends on mean annual air temperature (MAAT) and to a lesser extent on soil pH, whereas the relative abundance of cyclopentyl rings of branched GDGTs, expressed in the cyclisation ratio of branched tetraethers (CBT), is related to soil pH. The MBT/CBT proxies are increasingly used for the reconstruction of past air temperatures, but have rarely been applied in peatlands. Testate amoebae are common and diverse unicellular eukaryotes in peatlands. They build shells that are preserved in peat. They are good indicators of changing environmental conditions in peatlands and are thus used in both ecological and paleoecological studies, especially for reconstructing surface moisture. The aim of this study was to examine the applicability of branched GDGTs and testate amoebae as indicators of environmental changes (temperature and moisture) in temperate peatlands. Within the PEATWARM project, both GDGTs and testate amoebae were studied at high resolution in a 4 m peat core collected in Frasne mire (French Jura Mountains) and covering the last 7,400 years BP. GDGT-inferred temperatures ranged between 8 and 12 °C until 250 cm depth and were higher than present measured mean annual air temperature (ca. 6 °C). Temperature estimates in the top part of the bog were most consistent with spring and summer mean air temperatures recorded in the peatland (ca. 11.5 °C), suggesting that branched GDGT-producing bacteria might be more active

  13. Reconstructing Holocene palaeo-environmental conditions in the Baltic: A multi-proxy comparison from the Little Belt (IODP Expedition 347, Site M0059)

    Science.gov (United States)

    Kotthoff, Ulrich; Andrén, Elinor; Andrén, Thomas; Ash, Jeanine; Bauersachs, Thorsten; Fanget, Anne-Sophie; Granoszewski, Wojciech; Groeneveld, Jeroen; Krupinski, Nadine; Peyron, Odile; Slomp, Caroline; Stepanova, Anna; Warnock, Jonathan; van Helmond, Niels; Expedition 347 Science Party

    2016-04-01

    seasonality, but pollen-based reconstructions for Northern Europe may be hampered by plant migration effects. Palynomorph analyses are therefore complemented with analyses of lipid palaeothermometers, such as TEX86 and the long chain diol index (LDI), to reconstruct variations in Baltic Sea surface temperatures (SST). In addition, the MBT/CBT proxy is used to infer past changes in mean annual air temperatures (MAAT). Benthic foraminiferal δ18O and δ13C measurements (monospecific) and foraminifera and ostracod faunal assemblage analyses allow us to estimate bottom water salinity and environmental changes qualitatively and quantitatively. Low bottom water salinity (˜23 in bottom waters) and varying diagenesis in the Little Belt's organic-rich sediments complicates the application of benthic foraminiferal Mg/Ca as a palaeotemperature proxy. Reliable bottom water temperatures, however, are reconstructed using clumped isotope analyses of mollusc material. In addition, diatoms and the diol index (DI) are analysed to determine variation in salinity of the Baltic Sea's surface waters over the investigated time period. The results of this inter-proxy comparison study will be used to reconstruct gradients between different settings, e.g. how water column stratification developed, possibly if and how changes in seasonality occurred, and to identify the circumstances under which specific proxies may be affected by secondary impacts.

  14. Relationship between N-terminal pro brain natriuretic peptide and insulin sensitivity index in pa-tients with unstable angina pectoris%血浆NT-proBNP水平及胰岛素敏感性指标与不稳定型心绞痛危险分层相关研究

    Institute of Scientific and Technical Information of China (English)

    王培; 郑晓晖; 胡丰朝; 杨睿

    2014-01-01

    Objective To study the correlation of N-terminal pro brain natriuretic peptide( NT-proBNP)with insulin sensitivity index( FBG,FINS,FINS/FBG,ISI)in UAP patients,and its clinical significance. Methods One hundred patients with UAP were enrolled as the observation group,30 pa-tients with stable angina pectoris( SAP)as SAP group,and 30 healthy people as the normal control (COM)group. According to the Braunwald UAP,patients in UAP group were graded into 3 sup-groups( grade 1 ,grade 2 and grade 3 ). The plasma NT-proBNP and insulin sensitivity indexes were detected in each group,and then the results were analyzed and the linear correlation analysis was made. Results The concentration of plasma NT-proBNP,FINS,FINS/FBG in patients with UAP and SAP group were significantly higher than those in COM group( P﹤0. 05 ),but ISI was lower than that in COM group( P ﹤0. 05 ). The concentration of plasma NT-proBNP,FINS,FINS/FBG in patients with UAP were significantly higher than those in patients with SAP( P﹤0. 05 ),but ISI was lower than that in patients with SAP(P﹤0. 05),and there was no significant difference in FBG between the two groups. The concentration of plasma NT-proBNP,FINS,FINS/FBG in patients with grade 2 and grade 3 were significantly higher than those in patients with grade 1( P﹤0. 05 ),but ISI was lower in the grade 2( P﹤0. 05). No significant diference was found between grade 2 and grade 3. In UAP patients,the plasma NT-proBNP concentration was positively correlated with FINS,FINS/FBG( r =0. 38,P =0. 046,r =0. 56 ,P=0. 039 ),and negative correlated with ISI( r = -0. 62 ,P =0. 028 ),and with no correlation with FBG. Conclusions The concentration of plasma NT-proBNP was elevated and insulin sensitivity decreased in UAP, especially in Braunwald UAP grade 2 and grade 3( rest angina ),the concentration of NT-proBNP was negatively cor-related with insulin sensitivity. The combined determination is significant in risk grading reference of UAP.%目的:

  15. Hydrogen on the road. Environmental impact of hydrogen in automobiles; Waterstof onderweg. Milieu-impact van waterstof in personenwagens

    Energy Technology Data Exchange (ETDEWEB)

    Lambrechts, T.

    2008-08-15

    traditional fossil fuels. Only the hybrid vehicles and cars that use compressed natural gas as fuel have Ecoscores that are comparable with those of the fuel cell vehicles. The use of hydrogen in fuel cell-vehicles is thus ecological attractive according to the Ecoscore scale. Especially when renewable energy is used to produce the hydrogen. Further research is required to investigate the economical attractiveness. Some researchers point to the importance of the ecological impact of the fuel cell production. This is not included in the study and it is possible that this impact is much greater than that of the production of spark ignition motor. Further research is needed to clear this out. [Dutch] In het kader van de opwarming van de aarde en de uitstoot van broeikasgassen wordt er in de auto-industrie gezocht naar alternatieve brandstoffen. Die zouden er voor moeten zorgen dat onze behoefte aan geindividualiseerd transport bevredigd zou kunnen worden zonder een grootschalige milieu-impact te veroorzaken. Waterstof is een van de mogelijke alternatieven. Er wordt hier onderzocht in welke mate het gebruik van waterstof als brandstof een invloed zou hebben op de milieu-impact van het personentransport over de weg. Er bestaan veel manieren om waterstof te produceren, op te slaan, te transporteren en te gebruiken. In het eerste deel worden zij besproken aan de hand van een literatuurstudie. In het tweede deel worden zij gebruikt om verschillende configuraties te genereren. Hierbij worden reele en fictieve pathways uitgedacht waarbij verschillende methoden om waterstof te produceren, op te slaan en te transporteren gecombineerd worden met voertuigen met interne verbrandingsmotor en voertuigen met brandstofcellen. Zo werd een databank met emissiegegevens aangelegd. Aan de hand daarvan werden de Ecoscores berekend. Dit is een maat die de milieu-impact van voertuigen weergeeft. Op basis van die Ecoscores kan vastgesteld worden dat de brandstofcelvoertuigen ecologisch veel

  16. Sustainability pays. A reward system for sustainable producer and consumer behaviour; Duurzaam loont. Een beloningssysteem voor duurzaam consumentengedrag

    Energy Technology Data Exchange (ETDEWEB)

    Van Hilten, R. [QOIN, Amsterdam (Netherlands)

    2011-03-15

    vervoer, vrijwilligerswerk binnen de cultuursector, toegang tot bioscoop, theater of museum, muzieklessen, aanschaf van gezonde voeding, toegang tot zwembaden, lidmaatschap van een sportclub, etc. Bedrijven die de punten accepteren kunnen deze vervolgens bij de beheersorganisatie omwisselen in euro's. Consumenten kunnen de punten ook weggeven aan aangesloten organisaties. Huishoudens worden door de beloning geprikkeld om hun gedrag en levensstijl te veranderen, ten gunste van duurzaamheid. Ze maken meer gebruik van de cultuursector, sport, etc. Het levert voor huishoudens ook een kostenbesparing op. Toeristen kiezen vaker voor lokale restaurants, cultuur en bezoek aan lokale boeren. Winkels zien hun omzetten en winsten in het segment 'duurzaam' stijgen. Daarnaast is op maat reclame mogelijk doordat DUURZAAM LOONT de winkelier inzicht geeft in het koopgedrag van consumenten en de eigen klanten in het bijzonder. De gemeente krijgt de beschikking over een kosteneffectief en beproefd instrumentarium om beleid te realiseren. Belonen is effectiever en ook kosteneffectiever dan informatiecampagnes. Het stimuleert de regionale economie. Daarnaast krijgt de gemeente betere informatie over het effect van subsidie-euro's.