The Effect of Saccharomyces Strains and Fermentation Condition on the pH, Foam Property and CO2 Concentration of Non-alcoholic Beer (Ma-al-shaeer

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S. Sohrabvandi

2014-12-01

Full Text Available This study aims to determine the effect of fermentation condition and Saccharomyces strains on the pH, foam property and CO2 concentration of non-alcoholic beer (Ma-al-shaeer. For this, the beer samples were inoculated with four different species of Saccharomyces (Saccharomyces rouxii 70531, S. rouxii 70535, S. ludwigii 3447 and S. cerevisiae 70424 and fermented for 48h in both aerobic and periodic aeration at three different temperatures. Then their pH, CO2 concentration and foam property were analyzed in 12h intervals during 48h fermentation. The results shows that the treatments with 4×107 CFU.ml-1 and periodic aeration at 24˚C showed the greatest decrease in pH, and the treatments with 107 CFU.ml-1 and aerobic-periodic aeration at 4˚C showed the lowest decrease in pH. The highest and lowest amounts of CO2 and foam property were obtained in the treatments with 4×107 CFU.ml-1 inoculation, aerobic condition, and the treatments with 107 CFU.ml-1, periodic aeration, respectively. These results further demonstrated that the highest drop in pH, and the highest ability of producing CO2 and foam were for S. cerevisiae 70424, and the lowest belonged to S. rouxii 70531. The overall outcome of the study points to the fact that physico-chemical properties of Ma-al-shaeer is important from the consumers' point of view. Therefore, S. cerevisiae with 4×107 CFU.ml-1 inoculation and aerobic condition at 4˚C has promising potential for producing Ma-al-shaeer with good physicochemical properties.

Two-Pion Correlation Measurements for 14.6 A.GEV/C SILICON-28 + X and 11.6 A.GEV/C GOLD-197 + Gold.

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Soltz, Ron A.

Two-pion correlation functions have been measured in the central rapidity regions (1.5 < y < 2.0) for 14.6 A cdot GeV/c Si+Au to 2 pi^-+rm X (central and peripheral), Si+Al to 2pi^++ rm X (central and minimum bias), Si+Au to 2pi^++rm X (central), and 11.6 A cdot GeV/c Au+Au to 2pi^ -+rm X (central) systems. Two-dimensional fits in R-tau and R_{T}-R_ {L} were performed for these systems for different cuts in the total charged particle multiplicity and forward energy. The R, R_{T}, and R_{L} radius parameters for systems involving the Si projectile were found to increase with increasing charged particle multiplicity. These parameters were observed to scale linearly with A _sp{pp}{1/3}, where A_{pp} is the number of projectile participants as calculated from the forward energy deposition. The correlation functions were also fit to several three-dimensional functions. In all cases these fits proved to be consistent with the results of the two-dimensional fits. Events generated from the RQMD cascade code indicate that pions within experimental acceptance are produced from a region that is smaller than the entire region of pion production. A direct measure of the RQMD source for pions within the acceptance show qualitative agreement with the observed scaling. A minimization function was developed which is derived from the Poisson fluctuations in both the actual and background distributions. Progress was made in understanding the errors of event-mixed background distributions. An empirical study confirms that fluctuations within a bin are indeed Poisson for typical backgrounds generated during this analysis. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617 -253-5668; Fax 617-253-1690.).

a Theoretical Study of Coherent Structures in Nonneutral Plasma Columns

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Lund, Steven M.

A ubiquitous feature of experimental and computer simulation studies of magnetically confined pure electron plasmas in cylindrical confinement devices is the formation of nonaxisymmetric (partial/partial theta ne 0) rotating equilibria. In this dissertation, nonaxisymmetric rotating equilibria are investigated theoretically for strongly magnetized, low-density (omega_sp{pe} {2}/omega_sp{ce}{2 } guiding-center model in the cold-fluid limit (the continuity and Poisson equations) that treats the electrons as a massless fluid (m_{e} to 0) with E times B flow velocity V _{e} = -(c/B_0)nablaphi times {bf e}_{z}. Within this model, general rotating equilibria with electron density (n_{e} equiv n_{R}(r,theta-omega _{r}t) and electrostatic potential phi equiv phi_{R }(r,theta-omega_{r}t) have the property that the electron density is functionally related to the streamfunction psi _{R} = -ephi_{R} + omega_{r}(eB_0/2c)r^2 by n_{R} = n_{R }(psi_{R}). The streamfunction psi_{R} satisfies the nonlinear equilibrium equation nabla ^2psi_{R} = -4pi e^2n _{R}(psi_{R}) + 2omega_{r}eB_0/c with psi_{R} = omega _{r}(eB_0/2c)r_sp{w }{2} equiv psi_{w } = const. on the cylindrical wall at r = r_{w}. A general methodology for the solution of this equilibrium system is presented and several properties of rotating equilibria are analyzed. Following this analysis, two classes of nonaxisymmetric equilibria are investigated. These two classes of equilibria can have large amplitude (strongly nonaxisymmetric). First, a class of vortex-like rotating equilibria is analyzed that is characterized by a structured density profile that fills a confinement geometry with an inner conducting cylinder at radius r = r_{I} Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253 -1690.).

Optical confinement and light guiding in high dielectric contrast materials systems

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Foresi, James S.

A study of silicon photonic devices, including waveguides and microcavities, is presented in this thesis. The high index difference of Silicon-On-Insulator materials is used to design submicron devices capable of light localization and routing. Losses due to interface roughness between the high and low index materials are measured to be 40dB/cm. An analysis of lithographically induced interface roughness is performed and a method for evaluating nanometer-scale roughness is presented. High index differences lead to compact bends and power splitters. Bends of 2.0μm radius are measured to have losses less than 0.5dB. Splitting angles of 5o with losses less than 1.5dB are demonstrated. The bends and splitters are the most compact devices of their kind. The design, fabrication and analysis of two light confining devices in the SOI system are presented: photonic band gap (PBG) and microdisk microcavities. A PBG waveguide microcavity with minimum dimensions of 0.10μm is fabricated and transmission measurements reveal cavity Q's of 265, a resonant wavelength of 1564nm, and a modal volume of 0.27/mu m3. This is the first demonstration of PBG resonance at optical frequencies. The PBG microcavity volume is two orders of magnitude smaller than has been achieved in other microcavity devices. Microdisk and microring resonators are demonstrated. A waveguide-coupled microring is shown to operate as a channel dropping filter with Q's of 250 and a free spectral range of 25nm. The application of the microcavity devices to spontaneous emission control of erbium-doped silicon is analyzed. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

Constraints on early-type galaxy structure from spectroscopically selected gravitational lenses

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Bolton, Adam Stallard

2005-11-01

available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

An experimental study of turbulence by phase-contrast imaging in the DIII-D tokamak

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Coda, Stefano

1997-10-01

A CO2-laser imaging system employing the Zernike phase-contrast technique was designed, built, installed, and operated on the DIII-D tokamak. This system measures the line integrals of plasma density fluctuations along 16 vertical chords at the outer edge of the tokamak (0.85 Mechanical vibrations are damped by a novel dual-axis focal-spot feedback stabilization system. The theoretical treatment of scattering and imaging techniques was extended to finite-frequency fluctuations in the Rytov approximation. An extensive comparative analysis of the properties of phase-contrast imaging (PCI) and of other imaging and scintillation techniques was also carried out. Studies of edge turbulence were performed. The radial- wave-number spectrum peaks at finite wave numbers, both positive and negative. This first observation of radial modes is in agreement with recent predictions from theoretical and numerical work. The dependence of the correlation length and peak wave number on plasma parameters and on the frequency was studied in detail. Frequency spectra typically obey an inverse square law, consistent with a Lorentzian distribution. At the transition from L to H mode the amplitude and correlation length of the turbulence decrease, while the decorrelation time remains approximately constant. The Biglari-Diamond-Terry shear-decorrelation criterion was verified quantitatively; theoretical scaling laws for the correlation parameters were also tested. The turbulence amplitude follows a mixing-length scaling in L mode only: the lower level seen in H mode may indicate a weaker turbulence regime. The fluctuation content of Edge Localized Modes (ELMs) was thoroughly characterized, and systematic differences between type-I and type-III ELMs were discovered. Future applications of PCI, including crossed-beam localization and heterodyne radio-frequency-wave detection, are also discussed. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617

76 FR 45282 - Announcement of Funding Awards for the HUD-Veterans Affairs Supportive Housing (HUD-VASH) Program...

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2011-07-28

... AL 36801 $149,655 25 HOUSING AUTHORITY TUSCALOOSA....... 2117 Jack Warner Parkway... Tuscaloosa AL... Chauncy Street Boston MA 02111 $540,006 50 CAMBRIDGE HOUSING AUTHORITY........ 675 Massachusetts Avenue... Cambridge MA 02139 $372,900 25 NEW BEDFORD HOUSING AUTHORITY...... 134 South Second Street.... New Bedford...

75 FR 42172 - Agenda and Notice of Partially Closed Meeting of the Recovery Independent Advisory Panel

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2010-07-20

... Act of 2009, Public Law 111-5 (Recovery Act), and the Federal Advisory Committee Act of 1972 (FACA...: Hyatt Regency Cambridge, 575 Memorial Drive, Cambridge, MA 02139. FOR FURTHER INFORMATION CONTACT: Glen...

Cinéma en France

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Michel VIGOUROUX

1992-06-01

Full Text Available Le cinéma est l’objet de bases de données exhaustives sur les équipements et les fréquentations. Les données sur les salles permettent d’identifier le phénomène de concentration de propriété et d’exploitation. La perspective dynamique peut être observée sur 45 ans. À l’échelle régionale, on peut apprécier le dynamisme du cinéma en haute montagne alpine et la différence de réseaux sur le territoire (France de l’Ouest.

Geist, Logik, Kapital und die Technik des Maßes

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Frank Engster

2017-02-01

Full Text Available Hegels Phänomenologie des Geistes (PhdG und seine Wissenschaft der Logik (WdL sowie Marx Kapital sind, so wird im ersten Teil gezeigt, jeweils Ausdruck einer Verlegenheit. Alle drei stehen nämlich vor der Herausforderung, in Geist, Logik und Kapital letztlich eine Methode darstellen zu müssen, und sie müssen darüber auch noch die Möglichkeit der Darstellung ebendieser Methode einholen und begründen. Diese Übereinkunft zwischen der Methode der Darstellung mit dem Methodischen aufseiten des dargestellten Geistes, der Logik und des Kapitals gelingt, so die These des zweiten Teils, durch die Technik des Maßes. Maß und Messung konstituieren bereits in der Naturwissenschaft Objektivität im neuzeitlichen Sinne: Gehalten an und gebrochen durch ihre eigenen Maß, werden die Verhältnisse der Natur durch die ermittelten Werte wie ein selbständiger Gegenstand objektiv bestimmbar und im Wissen subjektiv aufgehoben. Dagegen zeigen Geist, Logik und Kapital jeweils, dass die Technik des Maßes nicht nur Objektivität im neuzeitlichen Sinne konstituiert, sondern die gesamte neuzeitliche Form der Gegenständlichkeit von Objektivität und Subjektivität, Bewusstsein und Gegenstand. In Hegels Phänomenologie und seiner Logik sowie in Marx Kapital eröffnet das Maß diese Gegenständlichkeit, indem jeweils eine Objektivität konstituiert wird, die einem Subjekt buchstäblich zu denken gegeben wird. Es ist allerdings unmittelbar die Objektivität der Subjektivität selbst, die jeweils gegeben wird: phänomenologisch wird durch das Maß die Objektivität der Subjektivität des Geistes gegeben (PhdG, rein logisch wird die Objektivität des Seins durch die Subjektivität des Begriffs gegeben (WdL, und der kapitalistischen Gesellschaft ist durch quantitative Werte die eigene Objektivität gegeben, und zwar gegeben durch ein Geld, das dadurch zu einer überindividuellen, automatischen Subjektivität wird. Für das Maß steht in der Phänomenologie das

76 FR 48172 - Prospective Grant of Exclusive License: Use of PKM2 Activators for the Treatment of Cancer

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2011-08-08

... Drive, Cambridge, MA 02139. The patent rights in these inventions have been assigned to the United... law, will not be released under the Freedom of Information Act, 5 U.S.C. 552. Dated: August 2, 2011...

High-Rate Field Demonstration of Large-Alphabet Quantum Key Distribution

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2017-05-22

Institute of Technology, Cambridge , MA 02139, USA 2Lincoln Laboratory, Massachusetts Institute of Technology, Lexington, MA 02420, USA Distribution A...the detectors or the readout electronics — is saturated by the incoming photon flux, 3 as illustrated in Figure 1(b). In this regime, which extends to...The deployed-fiber testbed comprised a pair of dark fibers running between the main campus of MIT in Cambridge , MA, and MIT Lincoln Laboratory in

Quantum Noise Reduction with Pulsed Light in Optical Fibers.

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Bergman, Keren

laboratory. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.).

Intracavitary ultrasound phased arrays for thermal therapies

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Hutchinson, Erin

that the heating capabilities of the constructed phased arrays were adequate for hyperthermia and thermal surgery treatments. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253- 1690.)

Beam Simulation Studies of Plasma-Surface Interactions in Fluorocarbon Etching of Silicon and Silicon Dioxide

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Gray, David C.

1992-01-01

-0551, Cambridge, MA 02139-4307. Ph. 617 -253-5668; Fax 617-253-1690.) (Abstract shortened with permission of school.).

Nonrelativistic Conformed Symmetry in 2 + 1 Dimensional Field Theory.

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Bergman, Oren

exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.).

Design and evaluation of cellular power converter architectures

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Perreault, David John

. This cellular system implements entirely distributed control, and achieves performance levels unattainable with an equivalent single converter. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

Intense Terahertz Fields for Fast Energy Release

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2016-11-01

1-0044 Keith Nelson Prepared by: Massachusetts Institute of Technology 77 Massachusetts Ave. Cambridge , MA 02139...schematic illustration and photo do not include the laser system that produces the THz and shock stimuli or the camera that records the sample

Development of Synthetic Catalysts for Peptide Bond Cleavage (Synthesis and Complete Kinetic Analysis of Compounds 6A, 7A, 8A).

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1987-08-05

03824 Dr. Ronald Breslow Columbia University Departmont of Cemistry New York, NY 10027 Dr. James P. Colmen Department of Cmistry Stanford University...of Massachusetts Amherst, MA 01003 Dr. Harden M. McConnell Stanford Univesity Department of Cemistry Stanford, CA 94305 Dr. Kristin lowtmn Mertes...Institute of Technology Cambridge, MA 02139 Dr. J. H. Richards California Institute of Technology Division of Cemistry and Ch e.cal Engineering

Reference Concepts for a Space-Based Hydrogen-Oxygen Combustion, Turboalternator, Burst Power System

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1990-07-01

Institute of Technology 1328 Albany Street Cambridge, MA 02139 Dave Berwald Grumman Aerospace Corporation MS B20-05 Bethpage, NY 11714 F. Best... Zielinski U. S. Department of Ener*gy SAN-ACR Division 13333 Broadway Oakland, CA 94612 G. L. Zigler Science & Engineering Associates 6301

Khorana, Prof. Har Gobind

Indian Academy of Sciences (India)

Elected: 1976 Honorary. Khorana, Prof. Har Gobind Nobel Laureate (Medicine) - 1968. Date of birth: 9 January 1922. Date of death: 9 November 2011. Last known address: Alfred P. Sloan Professor of, Biology and Chemistry, Massachusetts Institute of, Technology, 77 Massachusetts Ave., Cambridge, MA 02139, U.S.A..

Models for Multimegawatt Space Power Systems

Science.gov (United States)

1990-06-01

1328 Albany Street Cambridge, MA 02139 Dave Berwald Grumman Aerospace Corporation MS B20-05 Bethpage, NY 11714 F. Best Assistant Professor...Zercher Martin Marietta Corporation MS L8060 P. 0. Box 179 Denver, CO 80201 J. Zielinski U. S. Department of Energy SAN-ACR Division 13333

Deep Sea Moorings Fishbite Handbook

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1987-03-01

8217,ing a shear cut appearance = 75 Percent of ends having a fractured appearance = 2 Bold digits have been used to emphasize the most frequent...Institu.e of Marine Sciences Library MIT Libaries University of Alaska Serial Journal Room 14E-210 O’Neill Building Cambridge, MA 02139 905 Koyukuk Ave

Quantum Transport and Optoelectronics in Gapped Graphene Nanodevices

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2016-11-30

AVE CAMBRIDGE , MA 02139-4301 US 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) AF Office of...circles illustrate the phonon polariton waves launched by the AFM tip and reflected by the two edges of a tapered BN crystal. (b and d to f) IR near-field

Modelling the performance of interferometric gravitational-wave detectors with realistically imperfect optics

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Bochner, Brett

1998-12-01

has lower losses at the interferometer signal port than the Initial-LIGO system, though not significantly improved tolerance to mirror roughness deformations in terms of maintaining high signals. Finally, it is shown that 'Wavefront Healing', the claim that losses can be re- injected into the system to feed the gravitational wave signals, is successful in theory, but limited in practice for optics which cause large scattering losses. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253- 1690.)

Femtosecond Nonlinearities in Indium Gallium Arsenic Phosphide Diode Lasers

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Hall, Katherine Lavin

heating and an instantaneous electronic, or virtual process. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617 -253-5668; Fax 617-253-1690.).

The Extragalactic Lens VLBI Imaging Survey (ELVIS): Investigating galaxy cores and black holes with gravitational lens central images

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Boyce, Edward R.

This thesis describes the Extragalactic Lens VLBI Imaging Survey (ELVIS), a search for central images in gravitational lenses. We present the first four ELVIS targets, for which we have radio VLBI observations with resolutions of a few milli-arcseconds and sensitivities of 15 - 38mJy. For PMN J1838-3427, CLASS B0739+366 and CLASS B0445+123 we have not detected any central images, but have set stringent upper limits on their flux densities. For CLASS B2319+051 we have made a tentative detection of a third radio source, which may be either a central image or radio emission from the lens galaxy. Using the upper limits on the central image flux densities, we gain new information about the matter distributions in the lens galaxies of these systems. We fit a broken power law model for the matter profile, and constrain the allowed break radii and inner index of this model. To demagnify the central images to the observed level the matter profiles must be slightly shallower than or steeper than isothermal, which is consistent with previous studies of early type galaxy profiles. The presence of a super-massive black hole weakens the constraints somewhat, but the profiles are still close to isothermal. Relative to previous work, we reduce the maximum sizes of shallow cores by factors of 2 to 3, and raise the indices of r 0( r -g central cusps by g = 0.05 - 0.35. If we take the source in B2319+051 to be a central image, then we select a narrow band of allowed break radii and inner indices, finding that a constant density core has size 150--380 pc, and a pure power law has index g = 1.5 - 1.67. Our constraints still allow sufficiently shallow profiles that some super-massive black holes may form central image pairs rather than eliminating the central image, and these image pairs may be detected with future instruments. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

Magnetic reconnection physics in the solar wind with Voyager 2

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Stevens, Michael L.

2009-08-01

of thinning in Kelvin-Helmholtz unstable reconnection structures. I hypothesize that reconnection in turbulent environments occurs predominantly on smaller scales than one can measure with Voyager 2. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617- 253-5668; Fax 617-253-1690.)

Robust adaptive control modeling of human arm movements subject to altered gravity and mechanical loads

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Tryfonidis, Michail

visuomotor learning is important not only for error correction through internal model adaptation on ground or in microgravity, but also for the minimization of the total mean-square error in the presence of random variability. Thus human intelligent decision displays certain attributes that seem to conform to Bayesian statistical games. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

Anti-Ma and anti-Ma2-associated paraneoplastic neurological syndromes.

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Ortega Suero, G; Sola-Valls, N; Escudero, D; Saiz, A; Graus, F

Analyse the clinical profile, associated tumour types, and response to treatment of paraneoplastic neurological syndromes associated with antibodies against Ma proteins. A retrospective study of patients with antibodies against Ma proteins identified in a neuroimmunology laboratory of reference. Of the 32 patients identified, 20 showed reactivity against Ma2 only (anti-Ma2 antibodies), 11 against Ma1 and Ma2 (anti-Ma antibodies), and 1 with reactivity against Ma1 only (anti-Ma1 antibodies). The most common clinical presentations were limbic encephalopathy, diencephalic dysfunction, or brainstem encephalopathy, frequently appearing as a combination of these features. Three patients had isolated cerebellar dysfunction with anti-Ma antibodies, and 2 exhibited peripheral nervous system syndrome with anti-Ma2 antibodies. Testicular tumours were the most common neoplasms (40%) in the anti-Ma2 cases. In the group associated with anti-Ma1 antibodies, the most common were lung tumours (36%), followed by testicular tumours. All idiopathic cases were reactive to Ma2. The clinical outcome was significantly better in the anti-Ma2 group. The patient with anti-Ma1 presented with limbic encephalitis and brainstem dysfunction associated with lymphoepithelioma of the bladder. Specifically determining the different reactivities of anti-Ma protein antibodies in order to differentiate between Ma1 and Ma2 antibodies is important because anti-Ma2-associated paraneoplastic syndromes have a better outcome. Lastly, this study is the first to confirm that there may be cases that react exclusively to antibodies against Ma1. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

REGENERASI DAN PERBANYAKAN RUMPUT LAUT Kappaphycus alvarezii HASIL TRANSFORMASI GEN SUPEROKSIDA DISMUTASE (MaSOD

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Emma Suryati

2017-01-01

Full Text Available Transformasi gen superoxide dismutase (MaSOD pada rumput laut Kappaphycus alvarezii menggunakan Agrobacterium tumefacient telah dilakukan secara in vitro. Transformasi gen MaSOD ke dalam genom rumput laut diharapkan dapat mengurangi cekaman oksidatif terutama yang disebabkan oleh perubahan suhu, salinitas, dan cemaran logam di perairan. Penelitian ini bertujuan untuk regenerasi rumput laut hasil introduksi gen MaSOD dan non-transgenik pada labu kultur. Regenerasi dan perbanyakan rumput laut hasil transformasi gen MaSOD dilakukan di laboratorium pada labu kultur yang diletakkan dalam “culture chamber” yang dilengkapi dengan aerasi menggunakan media kultur yang diperkaya dengan pupuk PES, Grund, Conwy, dan SSW sebagai kontrol, salinitas 20, 25, 30, 35, dan 40 g/L, pH 4, 5, 6, 7, dan 8. Intensitas cahaya antara 500-2.000 lux dengan fotoperiode terang dan gelap 8:16; 12:12; dan 16:8. Untuk merangsang pertumbuhan eksplan dilakukan pemeliharaan dengan penambahan hormon tumbuh IAA dan BAP dengan perbandingan 1:1, 1:2, dan 2:1. Penelitian dilakukan secara bertahap. Evaluasi transgenik dilakukan menggunakan teknik PCR. Hasil penelitian memperlihatkan bahwa sintasan yang paling tinggi diperoleh menggunakan media PES (94%, salinitas 30 g/L (90%, pH 7 (96%, intensitas cahaya pada 1.500 lux (80%, fotoperiode 12:12 (84%, komposisi ZPT dengan campuran IAA dan BAP dengan perbandingan 2:1. Hasil analisis PCR memperlihatkan K. alvarezii transgenik putatif mengandung transgen MaSOD sebanyak 78% dari hasil transformasi. Superoxide dismutase transformation (MaSOD gene of seaweed Kappaphycus alvarezii mediated by Agrobacterium tumefacient has been successfully done in vitro. MaSOD genes introduced into the seaweed genome is expected to reduce oxidative stress caused by environmental conditions such as changes in temperature, salinity and metal contamination of the water. This study aimed to regenerate both the MaSOD transformed seaweed and non-transgenic in a

Anti-Ma2 antibody related paraneoplastic limbic/brain stem encephalitis associated with breast cancer expressing Ma1, Ma2, and Ma3 mRNAs.

Science.gov (United States)

Sahashi, K; Sakai, K; Mano, K; Hirose, G

2003-09-01

A 69 year old woman presented with cognitive impairment and supranuclear gaze palsy caused by paraneoplastic limbic/brain stem encephalitis associated with atypical medullary breast carcinoma. The cerebrospinal fluid from the patient harboured an anti-neuronal cell antibody against Ma2 antigen, but not against Ma1 or Ma3 antigen. Despite the antibody being restricted to the Ma2 antigen, the patient's cancer tissue expressed Ma1, Ma2, and Ma3 mRNAs. These results, and the expression of Ma2 mRNA in an atypical medullar breast carcinoma in another patient without paraneoplastic encephalitis, indicate that the induction of anti-Ma2 antibody depends on host immunoreponsiveness and not on the presence of the antigen itself in the cancer.

Toward a Theory of Representation Design

Science.gov (United States)

1989-05-01

understanding. This report describes research done at the Artificial Inteligence Laboratory of the Massachusetts Institute of Technology. Support for this...AD-A210 885 Technical Report 1128 Toward a Theory of Representation Design Jeffrey Van Baale MIT Artificial Intelligence Laboratory DTIC ELECTE A... Artificial Intelligence Laboratory 545 Technology Square Cambridge, MA 02139 11. CONTROLLING OFFICE NAME AND ADDRESS 11. REPORT DATE Advanced Research

Sensing Strategies for Disambiguating among Multiple Objects in Known Poses.

Science.gov (United States)

1985-08-01

ELEMENT. PROIECT. TASK Artificial Inteligence Laboratory AE OKUI UBR 545 Technology Square Cambridge, MA 021.39 11. CONTROLLING OFFICE NAME AND ADDRESS 12...AD-Ali65 912 SENSING STRATEGIES FOR DISAMBIGURTING MONG MULTIPLE 1/1 OBJECTS IN KNOWN POSES(U) MASSACHUSETTS INST OF TECH CAMBRIDGE ARTIFICIAL ...or Dist Special 1 ’ MASSACHUSETTS INSTITUTE OF TECHNOLOGY ARTIFICIAL INTELLIGENCE LABORATORY A. I. Memo 855 August, 1985 Sensing Strategies for

Cauldrons: An Abstraction for Concurrent Problems Solving. Revision.

Science.gov (United States)

1986-09-01

PROGRAM ELEMENT. PROJECT. TASK Artificial Inteligence Laboratory ARtA G WORK UNIT NUMVERS S 545 Technology Square etJ Cambridge, MA 02139 TIM II...D-11194 12611 CAU1,LDRONS: AN ROSTRACTION FOR CONCURRENT PROBLEMS1/ RSOLVING REYISION(U) MASSACHUSETTS INST OF TECHCANIRIDGE ARTIFICIAL INTELLIGENCE...is described, accompanied by cxanmple of their application to various domains. ’lhis report describes research done at both the MIT Artificial

Multistep Methods for Integrating the Solar System

Science.gov (United States)

1988-07-01

Technical Report 1055 [Multistep Methods for Integrating the Solar System 0 Panayotis A. Skordos’ MIT Artificial Intelligence Laboratory DTIC S D g8...RMA ELEENT. PROECT. TASK Artific ial Inteligence Laboratory ARE1A G WORK UNIT NUMBERS 545 Technology Square Cambridge, MA 02139 IL. CONTROLLING...describes research done at the Artificial Intelligence Laboratory of the Massachusetts Institute of Technology, supported by the Advanced Research Projects

33 CFR 80.135 - Hull, MA to Race Point, MA.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Hull, MA to Race Point, MA. 80... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.135 Hull, MA to Race Point, MA. (a... the east coast of Massachusetts from the easternmost radio tower at Hull, charted in approximate...

42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

Science.gov (United States)

2010-10-01

... qualifying MA-affiliated eligible hospitals under the MA EHR incentive program are required to identify...-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR MEDICARE... STANDARDS FOR THE ELECTRONIC HEALTH RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to Medicare...

Dynamical Systems and Motion Vision.

Science.gov (United States)

1988-04-01

TASK Artificial Inteligence Laboratory AREA I WORK UNIT NUMBERS 545 Technology Square . Cambridge, MA 02139 C\\ II. CONTROLLING OFFICE NAME ANO0 ADDRESS...INSTITUTE OF TECHNOLOGY ARTIFICIAL INTELLIGENCE LABORATORY A.I.Memo No. 1037 April, 1988 Dynamical Systems and Motion Vision Joachim Heel Abstract: In this... Artificial Intelligence L3 Laboratory of the Massachusetts Institute of Technology. Support for the Laboratory’s [1 Artificial Intelligence Research is

Herbert: A Second Generation Mobile Robot.

Science.gov (United States)

1988-01-01

PROJECT. TASK S Artificial Inteligence Laboratory AREA A WORK UNIT NUMBERS ’ ~ 545 Technology Square Cambridge, MA 02139 11. CONTROLLING OFFICE NAME...AD-AI93 632 WMRT: A SECOND GENERTION MOBILE ROWT(U) / MASSACHUSETTS IMST OF TECH CAMBRIDGE ARTIFICIAL INTELLIGENCE LAB R BROOKS ET AL .JAN l8 Al-M...MASSACHUSETTS INSTITUTE OF TECHNOLOGY ARTIFICIAL INTELLIGENCE LABORATORY A. I. Memo 1016 January, 1988 HERBERT: A SECOND GENERATION MOBILE ROBOT Rodney A

Simulation as an Engine of Physical Scene Understanding

Science.gov (United States)

2013-11-05

Percept Psychophys 16(1):4–8. 29. Zago M , McIntyre J, Senot P, Lacquaniti F (2009) Visuo-motor coordination and in- ternal models for object...Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 Edited by Richard M . Shiffrin, Indiana University, Bloomington, IN, and...inhabit. ACKNOWLEDGMENTS. We thank N. Kanwisher, E. Vul, T. Ullman, C. Baker, E. Davis, G. Marcus, and J. M . Tenenbaum for suggestions on the

Ma

Directory of Open Access Journals (Sweden)

Ingrid Berthon-Moine

2012-01-01

Full Text Available Ma (2009 is a single channel video of a mother and child walking together side by side, holding hands. The title is reminiscent of the affectionate nickname for a mother, 'Ma', but also a concealed way to convey maternal ambivalence. Maternal ambivalence is the result of the tension between the idealisation of motherhood and women’s lived experience of mothering. The maternal struggle finds its source in the difficulty of identifying with the ideological representation of the mother. This image still conveys an idealistic and nostalgic, patriarchal image of maternal love bounded by culture and history. http://podcast.ulcc.ac.uk/accounts/BirkbeckCollege/mamsie/MA.mov

Formation of M-Like Intermediates in Proteorhodopsin in Alkali Solutions (pH ≥ ∼8.5) Where the Proton Release Occurs First in Contrast to the Sequence at Lower pH.

Science.gov (United States)

Tamogami, Jun; Sato, Keitaro; Kurokawa, Sukuna; Yamada, Takumi; Nara, Toshifumi; Demura, Makoto; Miyauchi, Seiji; Kikukawa, Takashi; Muneyuki, Eiro; Kamo, Naoki

2016-02-23

Proteorhodopsin (PR) is an outward light-driven proton pump observed in marine eubacteria. Despite many structural and functional similarities to bacteriorhodopsin (BR) in archaea, which also acts as an outward proton pump, the mechanism of the photoinduced proton release and uptake is different between two H(+)-pumps. In this study, we investigated the pH dependence of the photocycle and proton transfer in PR reconstituted with the phospholipid membrane under alkaline conditions. Under these conditions, as the medium pH increased, a blue-shifted photoproduct (defined as Ma), which is different from M, with a pKa of ca. 9.2 was produced. The sequence of the photoinduced proton uptake and release during the photocycle was inverted with the increase in pH. A pKa value of ca. 9.5 was estimated for this inversion and was in good agreement with the pKa value of the formation of Ma (∼ 9.2). In addition, we measured the photoelectric current generated by PRs attached to a thin polymer film at varying pH. Interestingly, increases in the medium pH evoked bidirectional photocurrents, which may imply a possible reversal of the direction of the proton movement at alkaline pH. On the basis of these findings, a putative photocycle and proton transfer scheme in PR under alkaline pH conditions was proposed.

Exploiting Lexical Regularities in Designing Natural Language Systems.

Science.gov (United States)

1988-04-01

ELEMENT. PROJECT. TASKN Artificial Inteligence Laboratory A1A4WR NTumet 0) 545 Technology Square Cambridge, MA 02139 Ln *t- CONTROLLING OFFICE NAME AND...RO-RI95 922 EXPLOITING LEXICAL REGULARITIES IN DESIGNING NATURAL 1/1 LANGUAGE SYSTENS(U) MASSACHUSETTS INST OF TECH CAMBRIDGE ARTIFICIAL INTELLIGENCE...oes.ary and ftdou.Ip hr Nl wow" L,2This paper presents the lexical component of the START Question Answering system developed at the MIT Artificial

High-Energy, Multi-Octave-Spanning Mid-IR Sources via Adiabatic Difference Frequency Generation

Science.gov (United States)

2016-10-17

MASSACHUSETTS AVE CAMBRIDGE , MA 02139-4301 US 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) AF Office...ADFG) stage, illustrated in Fig. 2. This system represents a very simple extension of a near-IR OPCPA system to octave-spanning mid-IR, requiring...retrieved, as shown in Fig. 10. For illustration , 3 pulse shapes were selected. First, a simple linear chirp was applied to show that the pulse can be

GEO Satellites as Space Weather Sensors

Science.gov (United States)

2016-04-26

AFRL-AFOSR-VA-TR-2016-0161 GEO Satellites as Space Weather Sensors Kerri Cahoy MASSACHUSETTS INSTITUTE OF TECHNOLOGY 77 MASSACHUSETTS AVE CAMBRIDGE ... Cambridge , MA 02139 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) AF Office of Scientific...Lohmeyer  and  Cahoy,  2013;   Lohmeyer,  et  al.,  2015].  From  the   statistical  analysis,  we  identified  that

Interaction of Intense Lasers with Plasmas

Science.gov (United States)

Shvets, Gennady

1995-01-01

of wakefields in a hollow plasma channel by an intense laser pulse is studied analytically. An important finding is that the resonant absorption in the channel wall dissipates the accelerating wake, thereby introducing a finite quality factor of the hollow plasma channel and reducing the number of electron bunches that can be accelerated in the wake of a single laser pulse. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.) (Abstract shortened by UMI.).

Treatment of uncertainties in atmospheric chemical systems: A combined modeling and experimental approach

Science.gov (United States)

Pun, Betty Kong-Ling

1998-12-01

-second time scale. Fluctuations in pollutant concentrations were found to be extremely dependent on meteorological conditions. Deposition fluxes calculated using the Eddy Correlation technique were found to be small on concrete surfaces. These high time-resolution measurements were used to develop an understanding of the variability in atmospheric measurements, which would be useful in determining the acceptable discrepancy of model and observations. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

Experimental study of a 1 MW, 170 GHz gyrotron oscillator

Science.gov (United States)

Kimura, Takuji

, from which the beam velocity spreads are estimated. A preliminary test of the mode converter shows that the radiation from the dimpled wall launcher is a Gaussian-like beam. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139- 4307. Ph. 617-253-5668; Fax 617-253-1690.)

Radiation transport around Kerr black holes

Science.gov (United States)

Schnittman, Jeremy David

effects: the inverse-Compton process alters the photon spectrum by adding a high energy power-law tail, and the random scattering of each photon effectively damps out the highest frequency modulations in the X-ray light curve. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617- 253-5668; Fax 617-253-1690.)

Enhancing MA transmutation by irradiation of (MA, Zr)Hx in FBR blanket region - 5383

International Nuclear Information System (INIS)

Konashi, K.; Ikeda, K.; Itoh, K.; Hirai, M.; Koyama, T.; Kurosaki, K.

2015-01-01

Minor actinide (MA) hydride is proposed as transmutation target in sodium-cooled mixed oxide fuelled fast reactor. Preliminarily calculations have been done to check the transmutation efficiency of MA hydride targets. Three different types of MA target, MA-Zr alloy, (MA, Zr)O 2 and (MA, Zr)H x , have been compared on MA transmutation rate. The targets are assumed to be loaded around an active core in a 280 MWe sodium-cooled reactor; 54 MA target assemblies are respectively arranged in a row in the radial blanket zone. They are supposed to be irradiated for one year and then be cooled for 60 days. The transmuted mass has been evaluated by three-dimensional diffusion calculation to be 25, 15, 61 kg/EFPY for the alloy, the oxide and the hydride respectively, where production of MA in the active core is taken into account. The transmutation mass by (MA, Zr)H x is much larger than those by the other types of targets, while the core characteristics remain sound by locating MA targets outside of the active core. On top of that, two kinds of (MA, Zr)O 2 targets which are combined with ZrH x (x=1.7) pins have been calculated. Major Research/Development items are selected to establish the MA hydride transmutation method by reviewing technologies applicable to the transmutation system. The practical use of the MA hydride transmutation method is not far ahead technically, since this method can be developed by the extension of existing technologies. (authors)

The Synthesis of Force Closure Grasps in the Plane.

Science.gov (United States)

1985-09-01

TASK U Artificial Inteligence Laboratory AREA A WORK UN IT "NMUIERS ~( 545 Technology Square Cambridge, MA 02139 SI. CONTROLLING OFICE NAME ANO... ARTIFICIAL INThLLIX’ ENCE LABORATORY A. 1. Memo 861 September, 1985 The Synthesis of Force-Closure Grasps In the Plane DTIC ’VeL% ,#ECTE 1 VnDcNguyenU Abstract... Artificial In- telligenmcc Liabomatory of thle Massachuset Is hInsttute of Teclhnolog3 . Support for the Lahoratot * s Artificial Intelligence research is

Reification without Evaluation.

Science.gov (United States)

1988-06-01

PROJECT. TASK Artificial Inteligence Laboratory AREA & WORK UNIT NuMBERS ’’ 545 Technology Square 0 Cambridge, MA 02139 L $I 1, CONTROLLINO OFFICE NAME...7RD-ft" 28 REIFICRIO WITHOUT EYRURTION(U) rASSACHUSETTS INST OF 1/:LTECH CUZDGE ARTIFICI L INTELLIGENCE LUN R MEN JUN 60 RI-M-946 NM14-5-K-0-0124...themselves. This report, describes research done at, tie Artificial Intelligence Laboratory of the Massachusetts Institute of Technology. Support for the

The SME (Structure-Mapping Engine) User’s Manual (SME Version 2E)

Science.gov (United States)

1988-12-30

It is prior to this step that one might want to think about wether to modify any system parameters (e.g., print the match hypotheses, print only the...Wshington, DC 20390 Department of Psychology Carnegie-Mellon University Dr. Judith Orsanu Schenley Park Dr. Harold P. O’Neil, Jr. Basic Research Office...Pinker Baltimore, MD 21201 Department of Psychology ElO-018 Dr. Judith W. Segal MIT Dr. J. Wesley Regian OERI Cambridge, MA 02139 AFHRL/IDI 556 New

Tip-over Prevention: Adaptive Control Development

Science.gov (United States)

2015-05-30

Tip-over Prevention: Adaptive Control Development Leah Kelley Massachusetts Institute of Technology Cambridge, MA 02139 Email: lckelley@mit.edu Kurt...Papadopoulos and D. Rey, Proc. IEEE ICRA, vol.4, 1996, pp. 3111. [7] S. Ali, A. Moosavian, and K. Alipour, Robotics, Automation and Mechatronics , 2006 IEEE Conf...on, 2006, pp. 1–6. [8] K. Talke, L. Kelley, P. Longhini, and G. Catron, Proc. SPIE 9084, Unmanned Systems Technology XVI, June 2014, pp. 90 840L–11

Zhigang Ma

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. Zhigang Ma. Articles written in Bulletin of Materials Science. Volume 35 Issue 4 August 2012 pp 575-578. Degradation and miscibility of poly(DL-lactic acid)/poly(glycolic acid) composite films: Effect of poly(DL-lactic-co-glycolic acid) · Zhigang Ma Na Zhao Chengdong Xiong.

Scaling of X pinches from 1 MA to 6 MA

International Nuclear Information System (INIS)

Bland, Simon Nicholas; McBride, Ryan D.; Wenger, David Franklin; Sinars, Daniel Brian; Chittenden, Jeremy Paul; Pikuz, Sergei A.; Harding, Eric; Jennings, Christopher A.; Ampleford, David J.; Yu, Edmund P.; Cuneo, Michael Edward; Shelkovenko, Tatiana A.; Hansen, Stephanie B.

2010-01-01

This final report for Project 117863 summarizes progress made toward understanding how X-pinch load designs scale to high currents. The X-pinch load geometry was conceived in 1982 as a method to study the formation and properties of bright x-ray spots in z-pinch plasmas. X-pinch plasmas driven by 0.2 MA currents were found to have source sizes of 1 micron, temperatures >1 keV, lifetimes of 10-100 ps, and densities >0.1 times solid density. These conditions are believed to result from the direct magnetic compression of matter. Physical models that capture the behavior of 0.2 MA X pinches predict more extreme parameters at currents >1 MA. This project developed load designs for up to 6 MA on the SATURN facility and attempted to measure the resulting plasma parameters. Source sizes of 5-8 microns were observed in some cases along with evidence for high temperatures (several keV) and short time durations (<500 ps).

pH- and temperature-sensitive polymeric microspheres for drug delivery: the dissolution of copolymers modulates drug release.

Science.gov (United States)

Fundueanu, Gheorghe; Constantin, Marieta; Stanciu, Cristina; Theodoridis, Georgios; Ascenzi, Paolo

2009-12-01

Most pH-/temperature-responsive polymers for controlled release of drugs are used as cross-linked hydrogels. However, the solubility properties of the linear polymers below and above the lower critical solution temperature (LCST) are not exploited. Here, the preparation and characterization of poly (N-isopropylacrylamide-co-methacrylic acid-co-methyl methacrylate) (poly (NIPAAm-co-MA-co-MM)) and poly (N-isopropylacrylamide-co-acrylamide) (poly (NIPAAm-co-AAm)), known as "smart" polymers (SP), is reported. Both poly (NIPAAm-co-MA-co-MM) and poly (NIPAAm-co-AAm) display pH- and temperature-responsive properties. Poly (NIPAAm-co-MA-co-MM) was designed to be insoluble in the gastric fluid (pH = 1.2), but soluble in the intestinal fluid (pH = 6.8 and 7.4), at the body temperature (37 degrees C). Poly (NIPAAm-co-AAm) was designed to have a lower critical solution temperature (LCST) corresponding to 37 degrees C at pH = 7.4, therefore it is not soluble above the LCST. The solubility characteristics of these copolymers were exploited to modulate the rate of release of drugs by changing pH and/or temperature. These copolymers were solubilized with hydrophobic cellulose acetate butyrate (CAB) and vitamin B(12) (taken as a water soluble drug model system) in an acetone/methanol mixture and dispersed in mineral oil. By a progressive evaporation of the solvent, the liquid droplets were transformed into loaded CAB/SP microspheres. Differential scanning calorimetric studies and scanning electron microscopy analysis demonstrated that the polymeric components of the microspheres precipitated separately during solvent evaporation forming small microdomains. Moreover, vitamin B(12) was found to be molecularly dispersed in both microdomains with no specific affinity for any polymeric component of microspheres. The release of vitamin B(12) was investigated as a function of temperature, pH, and the CAB/SP ratio.

A natural mutation-led truncation in one of the two aluminum-activated malate transporter-like genes at the Ma locus is associated with low fruit acidity in apple.

Science.gov (United States)

Bai, Yang; Dougherty, Laura; Li, Mingjun; Fazio, Gennaro; Cheng, Lailiang; Xu, Kenong

2012-08-01

Acidity levels greatly affect the taste and flavor of fruit, and consequently its market value. In mature apple fruit, malic acid is the predominant organic acid. Several studies have confirmed that the major quantitative trait locus Ma largely controls the variation of fruit acidity levels. The Ma locus has recently been defined in a region of 150 kb that contains 44 predicted genes on chromosome 16 in the Golden Delicious genome. In this study, we identified two aluminum-activated malate transporter-like genes, designated Ma1 and Ma2, as strong candidates of Ma by narrowing down the Ma locus to 65-82 kb containing 12-19 predicted genes depending on the haplotypes. The Ma haplotypes were determined by sequencing two bacterial artificial chromosome clones from G.41 (an apple rootstock of genotype Mama) that cover the two distinct haplotypes at the Ma locus. Gene expression profiling in 18 apple germplasm accessions suggested that Ma1 is the major determinant at the Ma locus controlling fruit acidity as Ma1 is expressed at a much higher level than Ma2 and the Ma1 expression is significantly correlated with fruit titratable acidity (R (2) = 0.4543, P = 0.0021). In the coding sequences of low acidity alleles of Ma1 and Ma2, sequence variations at the amino acid level between Golden Delicious and G.41 were not detected. But the alleles for high acidity vary considerably between the two genotypes. The low acidity allele of Ma1, Ma1-1455A, is mainly characterized by a mutation at base 1455 in the open reading frame. The mutation leads to a premature stop codon that truncates the carboxyl terminus of Ma1-1455A by 84 amino acids compared with Ma1-1455G. A survey of 29 apple germplasm accessions using marker CAPS(1455) that targets the SNP(1455) in Ma1 showed that the CAPS(1455A) allele was associated completely with high pH and highly with low titratable acidity, suggesting that the natural mutation-led truncation is most likely responsible for the abolished function of Ma

Discovery and utilization of sorghum genes (Ma5/Ma6)

Science.gov (United States)

Mullet, John E; Rooney, William L; Klein, Patricia E; Morishige, Daryl; Murphy, Rebecca; Brady, Jeff A

2012-11-13

Methods and composition for the production of non-flowering or late flowering sorghum hybrid. For example, in certain aspects methods for use of molecular markers that constitute the Ma5/Ma6 pathway to modulate photoperiod sensitivity are described. The invention allows the production of plants having improved productivity and biomass generation.

Acidic pH facilitates peripheral αβmeATP-mediated nociception in rats: differential roles of P2X, P2Y, ASIC and TRPV1 receptors in ATP-induced mechanical allodynia and thermal hyperalgesia.

Science.gov (United States)

Seo, Hyoung-Sig; Roh, Dae-Hyun; Kwon, Soon-Gu; Yoon, Seo-Yeon; Kang, Suk-Yun; Moon, Ji-Young; Choi, Sheu-Ran; Beitz, Alvin J; Lee, Jang-Hern

2011-03-01

Peripheral ischemia is commonly associated with an increase in tissue ATP concentration and a decrease in tissue pH. Although in vitro data suggest that low tissue pH can affect ATP-binding affinities to P2 receptors, the mechanistic relationship between ATP and low pH on peripheral nociception has not been fully examined. This study was designed to investigate the potential role of an acidified environment on intraplantar αβmeATP-induced peripheral pain responses in rats. The mechanical allodynia (MA) produced by injection of αβmeATP was significantly increased in animals that received the drug diluted in pH 4.0 saline compared to those that received the drug diluted in pH 7.0 saline. Moreover, animals injected with αβmeATP (100 nmol) in pH 4.0 saline developed thermal hyperalgesia (TH), which did not occur in animals treated with αβmeATP diluted in pH 7.0 saline. To elucidate which receptors were involved in this pH-related facilitation of αβmeATP-induced MA and TH, rats were pretreated with PPADS (P2 antagonist), TNP-ATP (P2X antagonist), MRS2179 (P2Y1 antagonist), AMG9810 (TRPV1 antagonist) or amiloride (ASIC blocker). Both PPADS and TNP-ATP dose-dependently blocked pH-facilitated MA, while TH was significantly reduced by pre-treatment with MRS2179 or AMG9810. Moreover, amiloride injection significantly reduced low pH-induced facilitation of αβmeATP-mediated MA, but not TH. These results demonstrate that low tissue pH facilitates ATP-mediated MA via the activation of P2X receptors and ASICs, whereas TH induced by ATP under low pH conditions is mediated by the P2Y1 receptor and TRPV1, but not ASIC. Thus distinct mechanisms are responsible for the development of MA and TH under conditions of tissue acidosis and increased ATP. Copyright © 2010 Elsevier Ltd. All rights reserved.

Morotochoerus from Uganda (17.5 Ma and Kenyapotamus from Kenya (13-11 Ma: implications for hippopotamid origins

Directory of Open Access Journals (Sweden)

Pickford, M.

2011-12-01

Full Text Available The aim of this paper is to describe and interpret suiform teeth from Moroto, Uganda, and Ngorora, Kenya, which contribute to the debate about hippo-anthracothere-whale relationships. The early stages of hippopotamid evolution are relatively poorly known on account of the paucity of their fossil record older than 7 Ma. New specimens of Morotochoerus from Uganda reveal that it is not closely related to Hippopotamidae; the superficial resemblances of the cheek teeth to those of hippos represent convergences and not homologies. Restricted samples of Palaeopotamus ternani are available from the Middle Miocene of Kenya {Maboko, ca 16 Ma; Muruyur, ca 14.5 Ma; Fort Ternan, ca 13.7 Ma} while from the base of the late Miocene, Kenyapotamus coryndonae is known from Kenya {Ngerngerwa, ca 10.5-10 Ma; Nakali, ca 10.5 Ma; Samburu Hills, ca 9.5 Ma}, Ethiopia {Ch’orora, ca 10.5 Ma} and Tunisia {Beglia Formation ca 11-10 Ma}. The recovery of specimens of Kenyapotamus from the Ngorora Formation, Kenya, aged ca 11 Ma, is of interest because it includes well preserved teeth, including an m/3 in good condition. These specimens support the hypothesis that hippopotamids descended from palaeochoerids and not from anthracotheres.El objetivo de este trabajo es describir e interpretar los dientes suiformes de Moroto, Uganda, y Ngorora, Kenia, que contribuyen al debate sobre las relaciones hipo-anthracothere-whale. Las primeras etapas de la evolución de los hipopotámidos son relativamente poco conocidas a causa de la escasez de su registro fósil en edades superiors a los 7 Ma. Nuevos ejemplares de Morotochoerus en Uganda revelan que no están estrechamente relacionados con Hippopotamidae, las semejanzas superficiales de los dientes de la mandíbula con los de los hipopótamos representan convergencias y no homologías. Algunas muestras de Palaeopotamus ternani aparecen en el Medio Mioceno de Kenia {Maboko, ca 16 Ma; Muruyur, ca 14.5 Ma; Fort Ternan, ca 13.7 Ma

Model for Analysis of the Energy Demand (MAED) users' manual for version MAED-1

International Nuclear Information System (INIS)

1986-09-01

This manual is organized in two major parts. The first part includes eight main sections describing how to use the MAED-1 computer program and the second one consists of five appendices giving some additional information about the program. Concerning the main sections of the manual, Section 1 gives a summary description and some background information about the MAED-1 model. Section 2 extends the description of the MAED-1 model in more detail. Section 3 introduces some concepts, mainly related to the computer requirements imposed by the program, that are used throughout this document. Sections 4 to 7 describe how to execute each of the various programs (or modules) of the MAED-1 package. The description for each module shows the user how to prepare the control and data cards needed to execute the module and how to interpret the printed output produced. Section 8 recapitulates about the use of MAED-1 for carrying out energy and electricity planning studies, describes the several phases normally involved in this type of study and provides the user with practical hints about the most important aspects that need to be verified at each phase while executing the various MAED modules

A Initio Theoretical Studies of Surfaces of Semiconductors

Science.gov (United States)

Wang, Jing

1993-01-01

shall use the predictive power of the ab initio approach to help guide experimental interpreation of otherwise enigmatic STM measurements. In particular, we will demonstrate by example that the predictive power of ab initio calculation allows one to harness the native chemical selectivity of the scanning tunneling electron microscope (STM) and produce an unambiguous and fully interpretable non-destructive chemical probe at the atomic level. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253 -1690.) (Abstract shortened by UMI.).

Upper-Level Waves of Synoptic Scale at Midlatitudes

Science.gov (United States)

Rivest, Chantal

1990-01-01

. Basic states with positive tropospheric and stratospheric gradients of potential vorticity are found to support upper-level synoptic-scale waves for time scales consistent with observations. Following Farrell (1989), we then identify a class of near optimal initial conditions for the excitation of upper-level waves. The initial conditions consist of upper -tropospheric disturbances that lean against the shear. They strongly excite upper-level waves not only in the absence of tropospheric potential vorticity gradients, but also in their presence. This result demonstrates that quasi -modes are as likely to emerge from favorably configured initial conditions as real normal modes, although their excitation is followed by a slow decay. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.).

Faraday Rotation Studies of Indium Antimonide and CADMIUM(1-X) Manganese(x) Telluride

Science.gov (United States)

Jimenez Gonzalez, Hector J.

Brillouin zone as well as the lattice contribution from optical phonons. The multioscillator model explains the measured behavior of the Verdet constant as a function of photon energy for all the above values of x at both temperatures. This model has also been applied successfully to Faraday rotation data for Cd_ {1-x}Mn_{x}Te and Zn_{1-x}Mn _{x}Te from previous studies. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253 -1690.).

Symposium on Molecular Spectroscopy (39th) Held in Columbus, Ohio on 11-15 Jun 84.

Science.gov (United States)

1984-06-15

02139; R. BACIS, and S. CHURASSY, Laboratoire de Spectrometrie lonique et Moleculaire, Universit Claude Bernard (Lvon 1), 69622 Villeurbanne, France. r...Spectrometrie * lonique et Moleculaire, Universite Claude Bernard -Lyon I, 69622 Villeurbanne, - France; C. LINTON, Department of Physics, University of New...National Bureau of Standards. 3. S. Muenter and W. Klemperer, J. Chem. Phys. 52, 6033 (1970). 20. K. Hindermann and C. D. Cornwell , J. Chem. Ph-ys. 48

[Herbological studies on Chinese crude drug Ma-huang. Part 1-On the botanical origin of Ma-huang in ancient China and the origin of Japanese Ma-huang].

Science.gov (United States)

Yoshizawa, Chieko; Kitade, Makiko; Mikage, Masayuki

2005-01-01

The botanical origin of a Chinese crude drug Ma-huang in ancient China and the origin of Japanese Ma-huang were herbologically studied. The results showed that the plants of Ephedra sinica Stapf, E. intermedia Schrenk & C. A. Meyer and E. equisetina Bunge were used as Ma-huang in China, and the first species was considered to be of high quality. The characters of Mao-zhou Ma-huang and Tong-zhou Ma-huang printed in Tu-jing-ben-cao, published in the Song Dynasty in China, were identified as E. likiangensis Florin and E. intermedia, respectively, and both species were recognized as excellent Ma-huang in the Ming Dynasty. The word origin of Katsune-kusa, the Japanese name for Ma-huang in the Heian Era, was etymologically considered as meaning the plant having reddish brown roots. In Japan, the plant of Equisetum ramosissimum Desf. var.japonicum Milde, of the family Equisetaceae, was substituted for Ma-huang in the middle of Edo Era, and it was designated that this action was based on the confusion of Ephedra plants and Equisetum plants those days in China.

Ph3CCOOSnPh3.Ph3PO AND Ph3CCOOSnPh3.Ph3AsO: SYNTHESIS AND INFRARED STUDY

Directory of Open Access Journals (Sweden)

ABDOU MBAYE

2014-08-01

Full Text Available The mixture of ethanolic solutions of Ph3CCOOSnPh3 and Ph3PO or Ph3AsO gives Ph3CCOOSnPh3.Ph3PO and Ph3CCOOSnPh3.Ph3AsO adducts which have been characterized by infrared spectroscopy. A discrete structure is suggested for both, the environment around the tin centre being trigonal bipyramidal, the triphenylacetate anion behaving as a mondentate ligand.

Cistanche deserticola Y. C. Ma, "Desert ginseng": a review.

Science.gov (United States)

Wang, Tian; Zhang, Xiaoying; Xie, Wenyan

2012-01-01

Cistanche deserticola Y. C. Ma (C. deserticola, "Rou Cong Rong" in Chinese) is an officinal plant that grows in arid or semi-arid areas. The dried fleshy stem of C. deserticola has been generally used as a tonic in China and Japan for many years. Modern pharmacology studies have since demonstrated that C. deserticola possesses broad medicinal functions, especially for use in hormone regulation, aperient, immunomodulatory, neuroprotective, antioxidative, anti-apoptotic, anti-nociceptive, anti-inflammatory, anti-fatigue activities and the promotion of bone formation. The phenylethanoid glycosides (PhGs) presented in C. deserticola have been identified as the major active components. This review summarizes the up-to-date and comprehensive information on C. deserticola covering the aspects of the botany, traditional uses, phytochemistry, and pharmacology.

Anti Ma2-associated myeloradiculopathy: expanding the phenotype of anti-Ma2 associated paraneoplastic syndromes

OpenAIRE

Murphy, Sinead M; Khan, Usman; Alifrangis, Constantine; Hazell, Steven; Hrouda, David; Blake, Julian; Ball, Joanna; Gabriel, Carolyn; Markarian, Pierre; Rees, Jeremy; Karim, Abid; Seckl, Michael J; Lunn, Michael P; Reilly, Mary M

2011-01-01

Anti-Ma2 associated paraneoplastic syndrome usually presents as limbic encephalitis in association with testicular tumours.1, 2 Only four patients have been reported with involvement outside the CNS, two of whom also had limbic or brainstem encephalitis.2, 3 We report a man with anti- Ma2 associated myeloradiculopathy and previous testicular cancer whose neurological syndrome stabilised and anti-Ma2 titres fell following orchidectomy of a microscopically normal testis.

Electrolyte engineering toward efficient water splitting at mild pH

KAUST Repository

Shinagawa, Tatsuya; Ng, Marcus Tze-Kiat; Takanabe, Kazuhiro

2017-01-01

The development of processes for the conversion of H2O/CO2 driven by electricity generated in renewable manners is essential to achieve sustainable energy and chemical cycles, in which the electrocatalytic oxygen evolution reaction (OER) is one of the bottlenecks. In this contribution, the influences of the electrolyte molarity and identity on OER at alkaline to neutral pH were investigated at an appreciable current density of ~10 mA cm-2, revealing (1) the clear boundary of reactant switching between H2O/OH- due to the diffusion limitation of OH- and (2) the substantial contribution of the mass transport of the buffered species in buffered mild pH conditions. These findings propose a strategy of electrolyte engineering: tuning the electrolyte properties to maximize the mass-transport flux. The concept was successfully demonstrated for OER as well as overall water electrolysis in buffered mild pH conditions, shedding light on the development of practical solar fuel production systems.

Electrolyte engineering toward efficient water splitting at mild pH

KAUST Repository

Shinagawa, Tatsuya

2017-08-28

The development of processes for the conversion of H2O/CO2 driven by electricity generated in renewable manners is essential to achieve sustainable energy and chemical cycles, in which the electrocatalytic oxygen evolution reaction (OER) is one of the bottlenecks. In this contribution, the influences of the electrolyte molarity and identity on OER at alkaline to neutral pH were investigated at an appreciable current density of ~10 mA cm-2, revealing (1) the clear boundary of reactant switching between H2O/OH- due to the diffusion limitation of OH- and (2) the substantial contribution of the mass transport of the buffered species in buffered mild pH conditions. These findings propose a strategy of electrolyte engineering: tuning the electrolyte properties to maximize the mass-transport flux. The concept was successfully demonstrated for OER as well as overall water electrolysis in buffered mild pH conditions, shedding light on the development of practical solar fuel production systems.

Fuentes y dosis de nitrógeno en la productividad del maíz amarillo duro bajo dos sistemas de siembra

OpenAIRE

Sotomayor Alvarez, Raúl; Escuela de Post Grado, Especialidad de Producción Agrícola, Universidad Nacional Agraria La Molina, Apartado postal 12-056 – La Molina, Lima, Perú.; Chura Chuquija, Julián; Facultad de Agronomía, Universidad Nacional Agraria La Molina, Apartado postal 12-056 – La Molina, Lima, Perú.; Calderón Mendoza, Constantino; Facultad de Agronomía, Universidad Nacional Agraria La Molina, Apartado postal 12-056 – La Molina, Lima, Perú.; Sevilla Panizo, Ricardo; Facultad de Agronomía, Universidad Nacional Agraria La Molina, Apartado postal 12-056 – La Molina, Lima, Perú.; Blas Sevillano, Raúl; Facultad de Agronomía, Universidad Nacional Agraria La Molina, Apartado postal 12-056 – La Molina, Lima, Perú.

2017-01-01

Dado que el nitrógeno es el nutriente más importante para alcanzar altos rendimientos del cultivo de maíz, en el Instituto Nacional de Innovación Agraria-INIA (La Molina, Lima, Perú), se investigó la respuesta del cultivo de maíz amarillo duro a la fertilización nitrogenada con dos fuentes de insumo nitrogenado (sintético y orgánico) y con dos sistemas de siembra con riego por goteo en un suelo de textura franco arenoso, pH ligeramente alcalino y bajo en materia orgánica. Los tratamientos se ...

Integrated Modeling and Analysis of Physical Oceanographic and Acoustic Processes

Science.gov (United States)

2015-09-30

Institute of Technology Cambridge, MA 02139 phone: (617) 324-5172 fax: (617) 324-3451 email: pierrel@mit.edu Nicholas C. Makris Massachusetts...the phase function Γ so that α is tan -1(py / px). The canonical coordinates are ray position components (x and y) and phase gradient components...SSSS ds dp SSSS ds dy SSSS ds dx 1 2/12 2 2/12 2 2/12 2 2/12 2 tan cossin sincos α θ θ θ αα θ θ αα θ αθ αθ αθαθ αθαθ Here, s is the arc length along

Effects of Lactobacillus plantarum MA2 isolated from Tibet kefir on lipid metabolism and intestinal microflora of rats fed on high-cholesterol diet.

Science.gov (United States)

Wang, Yanping; Xu, Nv; Xi, Aodeng; Ahmed, Zaheer; Zhang, Bin; Bai, Xiaojia

2009-08-01

The objective of this study was to evaluate the effects of Lactobacillus plantarum MA2, an isolate from Chinese traditional Tibet kefir, on cholesterol-lowering and microflora of rat in vivo. Rats were fed on cholesterol-enriched experimental diet, supplemented with lyophilized L. plantarum MA2 powder, with a dose of 10(11) cells/day per mice. The results showed that L. plantarum MA2 feeding significantly lowered serum total cholesterol, low-density lipoprotein cholesterol, and triglycerides level, while there was no change in high-density lipoprotein cholesterol. In addition, liver total cholesterol and triglycerides was also decreased. However, fecal cholesterol and triglycerides was increased significantly (P MA2 increased the population of lactic acid bacteria and bifidobacteria in the fecal, but it did not change the number of Escherichia coli as compared to control. Moreover, pH, moisture, and organic acids in the fecal were also measured. The present results indicate the probiotic potential of the L. plantarum MA2 strain in hypocholesterolemic effect and also increasing the probiotic count in the intestine.

Produção de cidra de maçã

Directory of Open Access Journals (Sweden)

Ari de Arruda Veiga

1952-03-01

Full Text Available Diversos ensaios preliminares de vinificação do suco de maçã da variedade Ohio Beauty, cultivada em Valinhos, no Estado de São Paulo, demonstraram a viabilidade de se industrializar essa fruta e de serem obtidos principalmente diversos tipos de cidra. Trabalhando com sucos dessa variedade ácida, com um pH 2,70 em média, foram conseguidos bons tipos de cidra, que acusaram finalmente um pH = 3,60 em média. Constatou-se preferência na esterilização do suco pelo aquecimento a 65-67°C, e resfriamento a 30-35°C, antes da fermentação. Tanto a fermentação à baixa temperatura, 10-16°C, como a fermentação à temperatura ambiente, 23-28°C, deram bons resultados. O emprêgo de fermentos selecionados mostrou-se favorável à vinificação.Preliminary experiments are described on cider preparation, using the red skin Ohio Beauty apple variety cultivated at Valinhos, State of São Paulo. Starting with apple juice with a pH of 2.70, several cider types were obtained with an average pH of 3.60. Juice sterilization at temperatures of 65-67°C and subsequent lowering of temperature to 30-35°C before fermentation gave the best results. Temperature of 10-16°C as well as temperatures of 23-28°C during fermentation were used with success. Yeast strains selected for grape juice fermentation gave good results for fermentation of the apple juice here studied.

Identification and characterization of novel NuMA isoforms

Energy Technology Data Exchange (ETDEWEB)

Wu, Jin, E-mail: petersdu2112@hotmail.com [Key Laboratory for Cell Proliferation and Regulation of the Ministry of Education, Beijing Normal University, Beijing (China); Xu, Zhe [Department of Clinical Laboratory Diagnosis, Beijing Tiantan Hospital, Capital Medical University, Beijing (China); Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing (China); He, Dacheng [Key Laboratory for Cell Proliferation and Regulation of the Ministry of Education, Beijing Normal University, Beijing (China); Lu, Guanting, E-mail: guantlv@126.com [Beijing DnaLead Science and Technology Co., LTD, Beijing (China)

2014-11-21

Highlights: • Seven NuMA isoforms generated by alternative splicing were categorized into 3 groups: long, middle and short. • Both exons 15 and 16 in long NuMA were “hotspot” for alternative splicing. • Lower expression of short NuMA was observed in cancer cells compared with nonneoplastic controls. • Distinct localization pattern of short isoforms indicated different function from that of long and middle NuMA. - Abstract: The large nuclear mitotic apparatus (NuMA) has been investigated for over 30 years with functions related to the formation and maintenance of mitotic spindle poles during mitosis. However, the existence and functions of NuMA isoforms generated by alternative splicing remains unclear. In the present work, we show that at least seven NuMA isoforms (categorized into long, middle and short groups) generated by alternative splicing from a common NuMA mRNA precursor were discovered in HeLa cells and these isoforms differ mainly at the carboxyl terminus and the coiled-coil domains. Two “hotspot” exons with molecular mass of 3366-nt and 42-nt tend to be spliced during alternative splicing in long and middle groups. Furthermore, full-length coding sequences of long and middle NuMA obtained by using fusion PCR were constructed into GFP-tagged vector to illustrate their cellular localization. Long NuMA mainly localized in the nucleus with absence from nucleoli during interphase and translocated to the spindle poles in mitosis. Middle NuMA displayed the similar cell cycle-dependent distribution pattern as long NuMA. However, expression of NuMA short isoforms revealed a distinct subcellular localization. Short NuMA were present in the cytosol during the whole cycle, without colocalization with mitotic apparatus. These results have allowed us tentatively to explore a new research direction for NuMA’s various functions.

The (mis)Measurement of M&A Performance

DEFF Research Database (Denmark)

Meglio, Olimpia; Risberg, Annette

2011-01-01

This paper seeks to further the understanding of the variety of meanings M&A scholars attach to the label “M&A performance” by providing an alternative way to interpret the claimed inconsistency of M&A research findings. While many scholars contend that the problem stems from the multiplicity of M......&A performance measures, we believe the problem rests in trying to compare different measures as if they were measuring the same feature of the organization. Through our narrative review of empirical research we analyze factors shaping the M&A – as well as the organizational – performance measurement process....... The conclusion is that it is not possible to talk about M&A performance as if it was a universal construct....

Maïs beperkt nitraatverlies van gras

NARCIS (Netherlands)

Verloop, J.; Boumans, L.

2006-01-01

Maïs staat bekend als een gewas dat veel nitraat naar het grondwater lekt. Maar maïs heeft ook goeie kanten. Nieuw in dit rijtje is dat maïs, in vruchtwisseling met gras, ook het nitraatverlies van grasland beperkt. Dit blijkt uit de metingen van het RIVM op De Marke.

Guide to the Construction of a Simple 1500 C Test Furnace. Revision

Science.gov (United States)

1983-01-01

A.v e ~1 ue , ’..J -3- ~h i n~,;tor , [)( 20a:p. .. ·HTr~ : 0. Grove $ :~ . r~ . ~.p ;~ir;gs ~l o . of Copies. To ~~Liond l Scrence Foundat ioo...a~-. r~. !.indley ArRese<n·ch Manuf acturi ng Company , AiRe~earOr Cas t ing Company, ?s;~, Wr st ! 90th <,treet, Torrance, CA 90S05 .~TTN : Mr...Tec hnol ogy, De par t men t of i"P to 1 I.Jrgy and Mater i a ls Science , Cambri dge, MA 02139 ATTN : Prof . R. L. Cob l e Prof. H. K. Bowen

Bacillus coagulans MA-13: a promising thermophilic and cellulolytic strain for the production of lactic acid from lignocellulosic hydrolysate.

Science.gov (United States)

Aulitto, Martina; Fusco, Salvatore; Bartolucci, Simonetta; Franzén, Carl Johan; Contursi, Patrizia

2017-01-01

The transition from a petroleum-based economy towards more sustainable bioprocesses for the production of fuels and chemicals (circular economy) is necessary to alleviate the impact of anthropic activities on the global ecosystem. Lignocellulosic biomass-derived sugars are suitable alternative feedstocks that can be fermented or biochemically converted to value-added products. An example is lactic acid, which is an essential chemical for the production of polylactic acid, a biodegradable bioplastic. However, lactic acid is still mainly produced by Lactobacillus species via fermentation of starch-containing materials, the use of which competes with the supply of food and feed. A thermophilic and cellulolytic lactic acid producer was isolated from bean processing waste and was identified as a new strain of Bacillus coagulans , named MA-13. This bacterium fermented lignocellulose-derived sugars to lactic acid at 55 °C and pH 5.5. Moreover, it was found to be a robust strain able to tolerate high concentrations of hydrolysate obtained from wheat straw pre-treated by acid-catalysed (pre-)hydrolysis and steam explosion, especially when cultivated in controlled bioreactor conditions. Indeed, unlike what was observed in microscale cultivations (complete growth inhibition at hydrolysate concentrations above 50%), B. coagulans MA-13 was able to grow and ferment in 95% hydrolysate-containing bioreactor fermentations. This bacterium was also found to secrete soluble thermophilic cellulases, which could be produced at low temperature (37 °C), still retaining an optimal operational activity at 50 °C. The above-mentioned features make B. coagulans MA-13 an appealing starting point for future development of a consolidated bioprocess for production of lactic acid from lignocellulosic biomass, after further strain development by genetic and evolutionary engineering. Its optimal temperature and pH of growth match with the operational conditions of fungal enzymes hitherto

Isolation of MA-ACS Gene Family and Expression Study of MA-ACS1 Gene in Musa acuminata Cultivar Pisang Ambon Lumut

Directory of Open Access Journals (Sweden)

LISTYA UTAMI KARMAWAN

2009-03-01

Full Text Available Musa acuminata cultivar pisang ambon lumut is a native climacteric fruit from Indonesia. Climacteric fruit ripening process is triggered by the gaseous plant hormone ethylene. The rate limiting enzyme involved in ethylene biosynthesis is ACC synthase (ACS which is encoded by ACS gene family. The objective of this study is to identify MA-ACS gene family in M. acuminata cultivar pisang ambon lumut and to study the MA-ACS1 gene expression. The result showed that there were nine M. acuminata ACS gene family members called MA-ACS1–9. Two of them (MA-ACS1 and MA-ACS2 were assessed using reverse transcriptase PCR (RT-PCR for gene expression study and it was only MA-ACS1 correlated with fruit ripening. The MA-ACS1 gene fragment has been successfully isolated and characterized and it has three introns, four exons, and one stop codon. It also shows highest homology with MACS1 gene from M. acuminata cultivar Hsian Jien Chiao (GenBank accession number AF056164. Expression analysis of MA-ACS1 using quantitative PCR (qPCR showed that MA-ACS1 gene expression increased significantly in the third day, reached maximum at the fifth day, and then decreased in the seventh day after harvesting. The qPCR expression analysis result correlated with the result of physical analysis during fruit ripening.

A self-assembling peptide RADA16-I integrated with spider fibroin uncrystalline motifs

Directory of Open Access Journals (Sweden)

Sun L

2012-02-01

Full Text Available Lijuan Sun1,2, Xiaojun Zhao1,31West China Hospital Laboratory of Nanomedicine and Institute for Nanobiomedical Technology and Membrane Biology, Sichuan University, Chengdu 610041, Sichuan, China; 2Dept of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong, China; 3Center for Biomedical Engineering NE47-378, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USAAbstract: Mechanical strength of nanofiber scaffolds formed by the self-assembling peptide RADA16-I or its derivatives is not very good and limits their application. To address this problem, we inserted spidroin uncrystalline motifs, which confer incomparable elasticity and hydrophobicity to spider silk GGAGGS or GPGGY, into the C-terminus of RADA16-I to newly design two peptides: R3 (n-RADARADARADARADA-GGAGGS-c and R4 (n-RADARADARADARADA-GPGGY-c, and then observed the effect of these motifs on biophysical properties of the peptide. Atomic force microscopy, transmitting electron microscopy, and circular dichroism spectroscopy confirm that R3 and R4 display ß-sheet structure and self-assemble into long nanofibers. Compared with R3, the ß-sheet structure and nanofibers formed by R4 are more stable; they change to random coil and unordered aggregation at higher temperature. Rheology measurements indicate that novel peptides form hydrogel when induced by DMEM, and the storage modulus of R3 and R4 hydrogel is 0.5 times and 3 times higher than that of RADA16-I, respectively. Furthermore, R4 hydrogel remarkably promotes growth of liver cell L02 and liver cancer cell SMCC7721 compared with 2D culture, determined by MTT assay. Novel peptides still have potential as hydrophobic drug carriers; they can stabilize pyrene microcrystals in aqueous solution and deliver this into a lipophilic environment, identified by fluorescence emission spectra. Altogether, the spider fibroin motif GPGGY most effectively enhances mechanical

Control and Reliability of Optical Networks in Multiprocessors

Science.gov (United States)

Olsen, James Jonathan

1993-01-01

-based feedback system using BER levels for laser drive control. For hard failures, a common telecommunications solution is to provide redundant spare optical links to replace failed ones. Unfortunately, this involves the inclusion of many extra, otherwise unneeded optical links, most of which will remain unused throughout the system lifetime. I present a new approach, which I call 'bandwidth fallback', which allows continued use of partially-failed channels while still accepting full-width data inputs. This provides, at a very small performance penalty, a high reliability level while needing no spare links at all. I conclude that the drive control and reliability problems of semiconductor lasers do not bar their use in large scale multiprocessors, since inexpensive system-level solutions to them are possible. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617 -253-5668; Fax 617-253-1690.) (Abstract shortened by UMI.).

The Banana Fruit SINA Ubiquitin Ligase MaSINA1 Regulates the Stability of MaICE1 to be Negatively Involved in Cold Stress Response.

Science.gov (United States)

Fan, Zhong-Qi; Chen, Jian-Ye; Kuang, Jian-Fei; Lu, Wang-Jin; Shan, Wei

2017-01-01

The regulation of ICE1 protein stability is important to ensure effective cold stress response, and is extensively studied in Arabidopsis . Currently, how ICE1 stability in fruits under cold stress is controlled remains largely unknown. Here, we reported the possible involvement of a SEVEN IN ABSENTIA (SINA) ubiquitin ligase MaSINA1 from banana fruit in affecting MaICE1 stability. MaSINA1 was identified based on a yeast two-hybrid screening using MaICE1 as bait. Further yeast two-hybrid, pull-down, bimolecular fluorescence complementation (BiFC) and co-immunoprecipitation (CoIP) assays confirmed that MaSINA1 interacted with MaICE1. The expression of MaSINA1 was repressed by cold stress. Subcellular localization analysis in tobacco leaves showed that MaSINA1 was localized predominantly in the nucleus. In vitro ubiquitination assay showed that MaSINA1 possessed E3 ubiquitin ligase activity. More importantly, in vitro and semi- in vivo experiments indicated that MaSINA1 can ubiquitinate MaICE1 for the 26S proteasome-dependent degradation, and therefore suppressed the transcriptional activation of MaICE1 to MaNAC1, an important regulator of cold stress response of banana fruit. Collectively, our data reveal a mechanism in banana fruit for control of the stability of ICE1 and for the negative regulation of cold stress response by a SINA E3 ligase via the ubiquitin proteasome system.

Adole, MA

African Journals Online (AJOL)

Adole, MA. Vol 4, No 1 (2011) - Articles Effects of Groundnut Husk Ash-blended Cement on Chemical Resistance of Concrete Abstract PDF. ISSN: 1596-6035. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

Porous Si spheres encapsulated in carbon shells with enhanced anodic performance in lithium-ion batteries

International Nuclear Information System (INIS)

Wang, Hui; Wu, Ping; Shi, Huimin; Lou, Feijian; Tang, Yawen; Zhou, Tongge; Zhou, Yiming; Lu, Tianhong

2014-01-01

Highlights: • In situ magnesiothermic reduction route for the formation of porous Si@C spheres. • Unique microstructural characteristics of both porous sphere and carbon matrix. • Enhanced anodic performance in term of cycling stability for lithium-ion batteries. - Abstract: A novel type of porous Si–C micro/nano-hybrids, i.e., porous Si spheres encapsulated in carbon shells (porous Si@C spheres), has been constructed through the pyrolysis of polyvinylidene fluoride (PVDF) and subsequent magnesiothermic reduction methodology by using SiO 2 spheres as precursors. The as-synthesized porous Si@C spheres have been applied as anode materials for lithium-ion batteries (LIBs), and exhibit enhanced anodic performance in term of cycling stability compared with bare Si spheres. For example, the porous Si@C spheres are able to exhibit a high reversible capacity of 900.0 mA h g −1 after 20 cycles at a current density of 0.05 C (1 C = 4200 mA g −1 ), which is much higher than that of bare Si spheres (430.7 mA h g −1 )

FuSuMaTech workshop

CERN Multimedia

Olofsson, Simon

2018-01-01

The goal of the FuSuMaTecH IP workshop, organised at CERN Ideaquare 19-20 April, was to educate superconductivity and magnet experts about intellectual property. About 30 participants from multiple institutes and companies worked together in this two day interactive program which was facilitated by CERN Knowledge Transfer. Great progress was made in shaping the FuSuMaTech industrial demonstrator projects as well as the R&D&I subjects.

Upbeat nystagmus in anti-Ma2 encephalitis.

Science.gov (United States)

Garcia-Reitboeck, Pablo; Thompson, Graham; Johns, Paul; Al Wahab, Yasir; Omer, Salah; Griffin, Colette

2014-02-01

Anti-Ma2 encephalitis is a paraneoplastic disorder characterised by brainstem and/or limbic involvement. Eye movement abnormalities can occur in this condition, often with confusion or somnolence. We describe a patient with progressive oscillopsia (with upbeat nystagmus) and unsteadiness, followed by acute pancreatitis. She did not respond to immunomodulatory treatment and subsequently died of complications related to pancreatitis and sepsis. There was no tumour identified at autopsy, but the anti-Ma2 antibodies in her serum and the discovery of a brainstem-predominant inflammatory infiltrate at autopsy strongly suggest a paraneoplastic disorder. Our case illustrates that upbeat nystagmus can be a predominant feature in anti-Ma2 encephalitis; clinicians should consider testing for anti-Ma2 antibodies in patients with upbeat nystagmus of unknown cause.

Molecular and clinical diversity in paraneoplastic immunity to Ma proteins.

Science.gov (United States)

Rosenfeld, M R; Eichen, J G; Wade, D F; Posner, J B; Dalmau, J

2001-09-01

Antibodies to Ma1 and Ma2 proteins identify a paraneoplastic disorder that affects the limbic system, brain stem, and cerebellum. Preliminary studies suggested the existence of other Ma proteins and different patterns of immune response associated with distinct neurologic symptoms and cancers. In this study, our aim was to isolate the full-length sequence of Ma2 and new family members, identify the major autoantigen of the disorder, and extend the dinical-immunological analysis to 29 patients. Sera from selected patients were used to probe a brainstem cDNA library and isolate the entire Ma2 gene and a new family member, Ma3. Ma3 mRNA is ubiquitously expressed in brain, testis, and several systemic tissues. The variable cellular expression of Ma proteins and analysis of protein motifs suggest that these proteins play roles in the biogenesis of mRNA. Immunoblot studies identify Ma2 as the major autoantigen with unique epitopes recognized by all patients' sera. Eighteen patients had antibodies limited to Ma2: they developed limbic, hypothalamic, and brainstem encephalitis, and 78% had germ-cell tumors of the testis. Eleven patients had antibodies to Ma2 and additional antibodies to Ma1 and/or Ma3; they usually developed additional cerebellar symptoms and more intense brainstem dysfunction, and 82% of these patients had tumors other than germ-cell neoplasms. Overall, 17 of 24 patients (71%) with brain magnetic resonance imaging studies had abnormalities within or outside the temporal lobes, some as contrast-enhancing nodular lesions. A remarkable finding of immunity to Ma proteins is that neurologic symptoms may improve or resolve. This improvement segregated to a group of patients with antibodies limited to Ma2.

ReadMON: a portable readout system for the CERN PH-RADMON sensors

CERN Document Server

Mateu, Isidre; Gorine, Georgi; Moll, Michael; Pezzullo, Giuseppe; Ravotti, Federico

2018-01-01

PH-RADMON sensors are extensively used for radiation monitoring in the LHC experiments. Here, ReadMON, a dedicated and portable readout system for non-LHC applications, is presented. The system is able to source currents up to 32 mA and measure voltages up to 125 V, covering the full operational range of all dosimeters onboard the PH-RADMON sensor. Thus, the total measurement range of the system goes from 0.01 Gy to hundreds of kGy Total Ionizing Dose, and from few 10^10 neq/cm2 to 10^15 neq/cm2 1MeV neutron equivalent fluence. Different tests have been carried out at CERN IRRAD facility to prove the system concept and analyze its performance. Errors of only a few percent with respect to the readout done with a commercial Source Measuring Unit were found.

Efecto de la amonificación sobre el valor nutritivo del ensilaje de maíz

OpenAIRE

Pabón P., Ricardo A.; Toro B., J. Omar; Sánchez G., Hugo

2010-01-01

Mediante la técnica del microsilo, se midió el efecto de niveles de 0, 1, 2 y 3% de NH3 en base a la materia seca sobre el ensilaje de maíz con y sin mazorca. Las variables medidas fueron pH, temperatura, contenido de materia seca (%), contenido de proteína cruda (%), degradabilidad insitu de la materia seca y de la proteína cruda (%) a 48 horas de incubación ruminal. Los resultados muestran el efecto benéfico de la amonificación sobre la estabilidad del ensilaje y sobre su valor nutritivo. E...

Increase in physical activities in kindergarten children with cerebral palsy by employing MaKey-MaKey-based task systems.

Science.gov (United States)

Lin, Chien-Yu; Chang, Yu-Ming

2014-09-01

In this study, we employed Flash- and Scratch-based multimedia by using a MaKey-MaKey-based task system to increase the motivation level of children with cerebral palsy to perform physical activities. MaKey MaKey is a circuit board that converts physical touch to a digital signal, which is interpreted by a computer as a keyboard message. In this study, we used conductive materials to control this interaction. This study followed single-case design using ABAB models in which A indicated the baseline and B indicated the intervention. The experiment period comprised 1 month and a half. The experimental results demonstrated that in the case of two kindergarten children with cerebral palsy, their scores were considerably increased during the intervention phrases. The developmental applications of the results are also discussed. Copyright © 2014 Elsevier Ltd. All rights reserved.

MaRIE Undulator & XFEL Systems

Energy Technology Data Exchange (ETDEWEB)

Nguyen, Dinh Cong [Los Alamos National Laboratory; Marksteiner, Quinn R. [Los Alamos National Laboratory; Anisimov, Petr Mikhaylovich [Los Alamos National Laboratory; Buechler, Cynthia Eileen [Los Alamos National Laboratory

2015-03-23

The 22 slides in this presentation treat the subject under the following headings: MaRIE XFEL Performance Parameters, Input Electron Beam Parameters, Undulator Design, Genesis Simulations, Risks, and Summary It is concluded that time-dependent Genesis simulations show the MaRIE XFEL can deliver the number of photons within the required bandwidth, provided a number of assumptions are met; the highest risks are associated with the electron beam driving the XFEL undulator; and risks associated with the undulator and/or distributed seeding technique may be evaluated or retired by performing early validation experiments.

[Ma2 antibody and multiple mononeuropathies].

Science.gov (United States)

Ayrignac, X; Castelnovo, G; Landrault, E; Fayolle, H; Pers, Y-M; Honnorat, J; Campello, C; Figarella-Branger, D; Labauge, P

2008-01-01

Anti-Ma2 antibodies belong to a family of onconeuronal antibodies that target proteins expressed in brain, testis and several tumors. Previously observed in patients presenting with limbic encephalitis, they seem to be associated with several other paraneoplastic syndromes. We report the case of a 73-year-old woman presenting sensory and motor neuropathy associated with non-small-cell lung cancer who had Ma2-antibodies.

[Anti-Ma2-associated encephalitis and paraneoplastic limbic encephalitis].

Science.gov (United States)

Yamamoto, Tomotaka; Tsuji, Shoji

2010-08-01

Anti-Ma2-associated encephalitis (or anti-Ma2 encephalitis) is a paraneoplastic neurological syndrome (PNS) characterized by isolated or combined limbic, diencephalic, or brainstem dysfunction. Anti-Ma2 antibodies detected in the serum or cerebrospinal fluid of patients are highly specific for this disease entity and belong to a group of well-characterized onconeuronal antibodies (or classical antibodies). The corresponding antigen, Ma2 is selectively expressed intracellularly in neurons and tumors as is the case with other onconeuronal antigens targeted by classical antibodies. However, in most cases the clinical pictures are different from those of classical PNS and this creates a potential risk of underdiagnosis. Although limbic dysfunction is the most common manifestation in patients with anti-Ma2 encephalitis which is one of the major causes of paraneoplastic limbic encephalitis (LE), it has been reported that less than 30% of the patients with anti-Ma2 LE exhibit clinical presentations typical of the classical description of LE. Of the remaining, many exhibit excessive daytime sleepiness, vertical ophthalmoparesis, or both associated with LE, because of frequent involvement of the diencephalon and/or upper brainstem. Anti-Ma2 LE can also be manifested as a pure psychiatric disturbance such as obsessive-compulsive disorder in a few cases. Some patients develop mesodiencephalic encephalitis with minor involvement of the limbic system, and some may manifest severe hypokinesis. About 40% of the patients with anti-Ma2 antibodies also have antibodies against different epitopes on Ma1, a homologue of Ma2. These patients may have predominant cerebellar and/or brainstem dysfunctions due to more extensive involvement of subtentorial structures. Anti-Ma2 encephalitis is outstanding among other PNS associated with classical antibodies in that the response rate to treatment is relatively high. While it can cause severe neurological deficits or death in a substantial

Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis.

Science.gov (United States)

Overeem, S; Dalmau, J; Bataller, L; Nishino, S; Mignot, E; Verschuuren, J; Lammers, G J

2004-01-13

Idiopathic narcolepsy is associated with deficient hypocretin transmission. Narcoleptic symptoms have recently been described in paraneoplastic encephalitis with anti-Ma2 antibodies. The authors measured CSF hypocretin-1 levels in six patients with anti-Ma2 encephalitis, and screened for anti-Ma antibodies in patients with idiopathic narcolepsy. Anti-Ma autoantibodies were not detected in patients with idiopathic narcolepsy. Four patients with anti-Ma2 encephalitis had excessive daytime sleepiness; hypocretin-1 was not detectable in their cerebrospinal fluid, suggesting an immune-mediated hypocretin dysfunction.

PuMA: the Porous Microstructure Analysis software

Science.gov (United States)

Ferguson, Joseph C.; Panerai, Francesco; Borner, Arnaud; Mansour, Nagi N.

2018-01-01

The Porous Microstructure Analysis (PuMA) software has been developed in order to compute effective material properties and perform material response simulations on digitized microstructures of porous media. PuMA is able to import digital three-dimensional images obtained from X-ray microtomography or to generate artificial microstructures. PuMA also provides a module for interactive 3D visualizations. Version 2.1 includes modules to compute porosity, volume fractions, and surface area. Two finite difference Laplace solvers have been implemented to compute the continuum tortuosity factor, effective thermal conductivity, and effective electrical conductivity. A random method has been developed to compute tortuosity factors from the continuum to rarefied regimes. Representative elementary volume analysis can be performed on each property. The software also includes a time-dependent, particle-based model for the oxidation of fibrous materials. PuMA was developed for Linux operating systems and is available as a NASA software under a US & Foreign release.

Model for Analysis of Energy Demand (MAED-2)

International Nuclear Information System (INIS)

2007-01-01

The IAEA has been supporting its Member States in the area of energy planning for sustainable development. Development and dissemination of appropriate methodologies and their computer codes are important parts of this support. This manual has been produced to facilitate the use of the MAED model: Model for Analysis of Energy Demand. The methodology of the MAED model was originally developed by. B. Chateau and B. Lapillonne of the Institute Economique et Juridique de l'Energie (IEJE) of the University of Grenoble, France, and was presented as the MEDEE model. Since then the MEDEE model has been developed and adopted to be appropriate for modelling of various energy demand system. The IAEA adopted MEDEE-2 model and incorporated important modifications to make it more suitable for application in the developing countries, and it was named as the MAED model. The first version of the MAED model was designed for the DOS based system, which was later on converted for the Windows system. This manual presents the latest version of the MAED model. The most prominent feature of this version is its flexibility for representing structure of energy consumption. The model now allows country-specific representations of energy consumption patterns using the MAED methodology. The user can now disaggregate energy consumption according to the needs and/or data availability in her/his country. As such, MAED has now become a powerful tool for modelling widely diverse energy consumption patterns. This manual presents the model in details and provides guidelines for its application

Festivals de cinéma dans le monde arabe

Directory of Open Access Journals (Sweden)

Jean-Michel Frodon

2013-12-01

Full Text Available Alors que les deux grands festivals « historiques » du monde arabe, Carthage (JCC et Le Caire, sont entrés en décadence, on assiste depuis le début des années 2000 à une véritable explosion du phénomène festivalier dans le monde arabe. Le pays le plus en pointe est le Maroc, quoique de manière contrastée, avec une manifestation de prestige à Marrakech, et une nuée de petites manifestations. Dans les émirats du Golfe, la multiplication des festivals traduit une stratégie de communication plutôt qu’une volonté de développement culturel. Cette stratégie est fragilisée par la concurrence que se livrent les différents acteurs. Dans les autres pays arabes, on trouve une grande variété de situations sous le signe de la dispersion. Pourtant, l’accumulation de festivals (une centaine dans la région finit par avoir des effets d’ensemble, au-delà des buts, moyens et limites de chacun d’eux. Le phénomène festivalier, bien qu’inscrit dans des agendas locaux ou nationaux, génère de manière plus vaste des réseaux générationnels, financiers, de procédures d’expertise, de processus d’interrelation, géographiques mais aussi entre le cinéma et les autres arts ou médias.

Echt und modern? Diskurse über Männlichkeit

Directory of Open Access Journals (Sweden)

Florian Kahofer

2014-09-01

Full Text Available Der vorliegende Artikel befasst sich mit Repräsentationen von Männlichkeit im österreichischen Lifestyle-Magazin für Männer Wiener. Durch eine korpusbasierte Diskursanalyse wird ein umfassendes Korpus aller Ausgaben des Wieners von Anfang 2002 bis Ende 2012 untersucht. Auf theoretischer Ebene wird dabei eine Verbindung von Kritischer Männlichkeitsforschung (KMF und Feministisch Kritischer Diskursanalyse (FCDA unternommen. Es werden aktuelle Veröffentlichungen zu Kritischer Diskursanalyse und Männlichkeit vorgestellt und diskutiert. Durch den Einsatz einer Konkordanzsoftware werden Konkordanzen des Nomens MANN analysiert. Diese werden allerdings insofern eingeschränkt betrachtet, als nur Nominationen in der Form der häufigsten Adjektiv-Konstruktionen untersucht werden. Die Ergebnisse zeigen, dass neben den Diskursen über Krise und Neue Männlichkeit Themen wie Alter, Körper oder Beziehung auftauchen. Männlichkeit wird als ambivalent und vielfältig dargestellt. Deutungskämpfe um Männlichkeit lassen sich ausmachen.

Treatment of anti-Ma2/Ta paraneoplastic syndrome.

Science.gov (United States)

Kraker, Jessica

2009-01-01

The paraneoplastic syndrome caused by Ma2/Ta antibodies alone (not in conjunction with Ma1 or Ma3 antibodies) varies in presentation from classic limbic encephalitis. The Ma2 syndrome may present with symptoms referable to the brainstem, diencephalon, and limbic system. These clinical symptoms are accompanied by MRI changes and abnormal electroencephalographic findings. It is important to recognize when the encephalitic syndrome is secondary to Ma2 paraneoplastic antibodies, as the patients improve or stabilize most often when the underlying carcinoma is treated. Treatment of the paraneoplastic syndrome begins with recognition of the symptoms, such as memory impairment, seizures, sleep disturbances, bradykinesia or hypokinesia, and eye movement abnormalities. If a primary tumor is discovered during the workup, it should be removed and treated with the most up-to-date oncologic treatment available. In addition to oncologic treatment, the syndrome may be treated with an immunosuppressant regimen to optimize the neurologic outcome. Leaving the patient untreated will result in decline and eventual death from the cancer itself or from complications of the paraneoplastic syndrome.

A PhD is a PhD is a PhD

OpenAIRE

Ostrow, Deborah Anne

2017-01-01

A PhD is a PhD is a PhD is a practice-based project that interrogates the process of an artist undertaking PhD research under established criteria. It consists of an exegesis, an original screenplay, and a digital film made for online viewing, with images drawn from a range of documentaries and films found on YouTube. They have been dissected, re-assembled and then re-embedded to YouTube. The source material covers topics such as medicalization of madness, the conspicuous appropriation of uni...

Compter mes jours : recherche explorant l'espace entre ma pratique artistique et ma pratique comptable

OpenAIRE

Picard, Julie

2017-01-01

Cette recherche propose d’investiguer l’espace entre ma pratique artistique et ma pratique comptable à travers une approche qui déploie des activités de recherches théoriques sur l’art, des activités de recherches théoriques en comptabilité, la réalisation d’un protocole de création en atelier, et la prestation d’une conférence. L’approche flexible, multifocale et exploratoire adoptée se situe en affinité avec Intermedia, développé par Dick Higgins. Partant de ces deux figures type d’oppositi...

Synthesis of 9,9,9-trideutero-1,4-dihydroxynonane mercapturic acid (d3-DHN-MA), a useful internal standard for DHN-MA urinalysis.

Science.gov (United States)

Chantegrel, B; Deshayes, C; Doutheau, A; Steghens, J P

2002-10-01

Racemic 1,4-dihydroxynonane mercapturic acid (DHN-MA) and 9,9,9-trideutero-1,4-dihydroxynonane mercapturic acid (d3-DHN-MA) are synthesized on a 400-mg scale (overall yield approximately 40%) by a two-step sequence involving Michael addition of N-acetyl-L-cysteine to methyl 4-hydroxynon-2(E)-enoate or methyl 9,9,9-trideutero-4-hydroxynon-2 (E)-enoate, followed by reduction of the intermediate adducts with lithium borohydride. The requisite starting methyl esters are obtained, respectively, from heptanal or 7,7,7-trideuteroheptanal and methyl 4-chlorophenylsulfinylacetate via a sulfoxide piperidine and carbonyl reaction described in the literature. The 7,7,7-trideuteroheptanal is easily prepared by classical methods in four steps from 6-bromo-1-hexanol. 13C NMR data indicate that DHN-MA as well as d3-DHN-MA are obtained as mixtures of four diastereomers. Preliminary results show that d3-DHN-MA could be used as an internal standard for mass spectrometric quantification of DHN-MA in human urine.

MA-burners efficiency parameters allowing for the duration of transmutation process

International Nuclear Information System (INIS)

Gulevich, A.; Zemskov, E.; Kalugin, A.; Ponomarev, L.; Seliverstov, V.; Seregin, M.

2010-01-01

Transmutation of minor actinides (MA) means their transforming into the fission products. Usually, MA-burner's transmutation efficiency is characterized by the static parameters only, such as the number of neutrons absorbed and the rate of MA feeding. However, the proper characterization of MA-burner's efficiency additionally requires the consideration of parameters allowing for the duration of the MA transmutation process. Two parameters of that kind are proposed: a) transmutation time τ - mean time period from the moment a mass of MA is loaded into the burner's fuel cycle to be transmuted to the moment this mass is completely transmuted; b) number of reprocessing cycles n rep - effective number of reprocessing cycles a mass of loaded MA has to undergo before being completely transmuted. Some of MA-burners' types have been analyzed from the point of view of these parameters. It turned out that all of them have the value of parameters too high from the practical point of view. It appears that some new approaches to MA-burner's design have to be used to significantly reduce the value of these parameters in order to make the large-scale MA transmutation process practically reasonable. Some of such approaches are proposed and their potential efficiency is discussed. (authors)

An ENA ATPase, MaENA1, of Metarhizium acridum influences the Na(+)-, thermo- and UV-tolerances of conidia and is involved in multiple mechanisms of stress tolerance.

Science.gov (United States)

Ma, Qinsi; Jin, Kai; Peng, Guoxiong; Xia, Yuxian

2015-10-01

In fungi, ENA ATPases play key roles in osmotic and alkaline pH tolerance, although their functions in thermo- and UV-tolerances have not been explored. Entomopathogenic fungi are naturally widespread and have considerable potential in pest control. An ENA ATPase gene, MaENA1, from the entomopathogenic fungus Metarhizium acridum was functionally analyzed by deletion. MaENA1-disruption strain (ΔMaENA1) was less tolerant to NaCl, heat, and UV radiation than a wild-type strain (WT). Digital Gene Expression profiling of conidial RNAs resulted in 281 differentially expressed genes (DEGs) between the WT and ΔMaENA1 strains. Eighty-five DEGs, 56 of which were down-regulated in the ΔMaENA1 strain, were shown to be associated with heat/UV tolerance, including six cytochrome P450 superfamily genes, 35 oxidoreductase genes, 24 ion-binding genes, seven DNA repair genes, and five other genes. In addition, eight genes were components of stress responsive pathways, including the Ras-cAMP PKA pathway, the RIM101 pathway, the Ca(2+)/calmodulin pathway, the TOR pathway, and the HOG/Spc1/Sty1/JNK pathway. These results demonstrated that MaENA1 influences fungal tolerances to Na(+), heat, and UV radiation in M. acridum, and is involved in multiple mechanisms of stress tolerance. Therefore, MaENA1 is required for the adaptation and survival of entomopathogenic fungi in stressful conditions in the environment and in their hosts. Copyright © 2015 Elsevier Inc. All rights reserved.

Synthesis, Biodistribution and In vitro Evaluation of Brain Permeable High Affinity Type 2 Cannabinoid Receptor Agonists [11C]MA2 and [18F]MA3.

Science.gov (United States)

Ahamed, Muneer; van Veghel, Daisy; Ullmer, Christoph; Van Laere, Koen; Verbruggen, Alfons; Bormans, Guy M

2016-01-01

The type 2 cannabinoid receptor (CB2) is a member of the endocannabinoid system and is known for its important role in (neuro)inflammation. A PET-imaging agent that allows in vivo visualization of CB2 expression may thus allow quantification of neuroinflammation. In this paper, we report the synthesis, radiosynthesis, biodistribution and in vitro evaluation of a carbon-11 ([ 11 C]MA2) and a fluorine-18 ([ 18 F]MA3) labeled analog of a highly potent N -arylamide oxadiazole CB2 agonist (EC 50 = 0.015 nM). MA2 and MA3 behaved as potent CB2 agonist (EC 50 : 3 nM and 0.1 nM, respectively) and their in vitro binding affinity for h CB2 was found to be 87 nM and 0.8 nM, respectively. Also MA3 (substituted with a fluoro ethyl group) was found to have higher binding affinity and EC 50 values when compared to the originally reported trifluoromethyl analog 12 . [ 11 C]MA2 and [ 18 F]MA3 were successfully synthesized with good radiochemical yield, high radiochemical purity and high specific activity. In mice, both tracers were efficiently cleared from blood and all major organs by the hepatobiliary pathway and importantly these compounds showed high brain uptake. In conclusion, [ 11 C]MA2 and [ 18 F]MA3 are shown to be high potent CB2 agonists with good brain uptake, these favorable characteristics makes them potential PET probes for in vivo imaging of brain CB2 receptors. However, in view of its higher affinity and selectivity, further detailed evaluation of MA3 as a PET tracer for CB2 is warranted.

MA-burners efficiency parameters allowing for the duration of transmutation process

Energy Technology Data Exchange (ETDEWEB)

Gulevich, A.; Zemskov, E. [Institute of Physics and Power Engineering, Bondarenko Square 1, Obninsk, Kaluga Region 249020 (Russian Federation); Kalugin, A.; Ponomarev, L. [Russian Research Center ' ' Kurchatov Institute' ' Kurchatov Square 1, Moscow 123182 (Russian Federation); Seliverstov, V. [Institute of Theoretical and Experimental Physics ul.B. Cheremushkinskaya 25, Moscow 117259 (Russian Federation); Seregin, M. [Russian Research Institute of Chemical Technology Kashirskoe Shosse 33, Moscow 115230 (Russian Federation)

2010-07-01

Transmutation of minor actinides (MA) means their transforming into the fission products. Usually, MA-burner's transmutation efficiency is characterized by the static parameters only, such as the number of neutrons absorbed and the rate of MA feeding. However, the proper characterization of MA-burner's efficiency additionally requires the consideration of parameters allowing for the duration of the MA transmutation process. Two parameters of that kind are proposed: a) transmutation time {tau} - mean time period from the moment a mass of MA is loaded into the burner's fuel cycle to be transmuted to the moment this mass is completely transmuted; b) number of reprocessing cycles n{sub rep} - effective number of reprocessing cycles a mass of loaded MA has to undergo before being completely transmuted. Some of MA-burners' types have been analyzed from the point of view of these parameters. It turned out that all of them have the value of parameters too high from the practical point of view. It appears that some new approaches to MA-burner's design have to be used to significantly reduce the value of these parameters in order to make the large-scale MA transmutation process practically reasonable. Some of such approaches are proposed and their potential efficiency is discussed. (authors)

Porous Si spheres encapsulated in carbon shells with enhanced anodic performance in lithium-ion batteries

Energy Technology Data Exchange (ETDEWEB)

Wang, Hui; Wu, Ping, E-mail: zjuwuping@njnu.edu.cn; Shi, Huimin; Lou, Feijian; Tang, Yawen; Zhou, Tongge; Zhou, Yiming, E-mail: zhouyiming@njnu.edu.cn; Lu, Tianhong

2014-07-01

Highlights: • In situ magnesiothermic reduction route for the formation of porous Si@C spheres. • Unique microstructural characteristics of both porous sphere and carbon matrix. • Enhanced anodic performance in term of cycling stability for lithium-ion batteries. - Abstract: A novel type of porous Si–C micro/nano-hybrids, i.e., porous Si spheres encapsulated in carbon shells (porous Si@C spheres), has been constructed through the pyrolysis of polyvinylidene fluoride (PVDF) and subsequent magnesiothermic reduction methodology by using SiO{sub 2} spheres as precursors. The as-synthesized porous Si@C spheres have been applied as anode materials for lithium-ion batteries (LIBs), and exhibit enhanced anodic performance in term of cycling stability compared with bare Si spheres. For example, the porous Si@C spheres are able to exhibit a high reversible capacity of 900.0 mA h g{sup −1} after 20 cycles at a current density of 0.05 C (1 C = 4200 mA g{sup −1}), which is much higher than that of bare Si spheres (430.7 mA h g{sup −1})

Synthesis, biodistribution and in vitro evaluation of brain permeable high affinity type 2 cannabinoid receptor agonists [11C]MA2 and [18F]MA3

Directory of Open Access Journals (Sweden)

Muneer Ahamed

2016-09-01

Full Text Available Abstract The type 2 cannabinoid receptor (CB2 is a member of the endocannabinoid system and is known for its important role in (neuroinflammation. A PET-imaging agent that allows in vivo visualization of CB2 expression may thus allow quantification of neuroinflammation. In this paper, we report the synthesis, radiosynthesis, biodistribution and in vitro evaluation of a carbon-11 ([11C]MA2 and a fluorine-18 ([18F]MA3 labeled analogue of a highly potent N-arylamide oxadiazole CB2 agonist (EC50 = 0.015 nM. MA2 and MA3 behaved as potent CB2 agonist (EC50: 3 nM and 0.1 nM, respectively and their in vitro binding affinity for hCB2 was found to be 87 nM and 0.8 nM, respectively. Also MA3 (substituted with a fluoro ethyl group was found to have higher binding affinity and EC50 values when compared to the originally reported trifluoromethyl analogue 12. [11C]MA2 and [18F]MA3 were successfully synthesized with good radiochemical yield, high radiochemical purity and high specific activity. In mice, both tracers were efficiently cleared from blood and all major organs by the hepatobiliary pathway and importantly these compounds showed high brain uptake. In conclusion, [11C]MA2 and [18F]MA3 are shown to be high potent CB2 agonists with good brain uptake, these favorable characteristics makes them potential PET probes for in vivo imaging of brain CB2 receptors. However in view of its higher affinity and selectivity, further detailed evaluation of MA3 as a PET tracer for CB2 is warranted.

The HectoMAP Cluster Survey. I. redMaPPer Clusters

Science.gov (United States)

Sohn, Jubee; Geller, Margaret J.; Rines, Kenneth J.; Hwang, Ho Seong; Utsumi, Yousuke; Diaferio, Antonaldo

2018-04-01

We use the dense HectoMAP redshift survey to explore the properties of 104 redMaPPer cluster candidates. The redMaPPer systems in HectoMAP cover the full range of richness and redshift (0.08 systems included in the Subaru/Hyper Suprime-Cam public data release are bona fide clusters. The median number of spectroscopic members per cluster is ∼20. We include redshifts of 3547 member candidates listed in the redMaPPer catalog whether they are cluster members or not. We evaluate the redMaPPer membership probability spectroscopically. The purity (number of real systems) in redMaPPer exceeds 90% even at the lowest richness. Three massive galaxy clusters (M ∼ 2 × 1013 M ⊙) associated with X-ray emission in the HectoMAP region are not included in the public redMaPPer catalog with λ rich > 20, because they lie outside the cuts for this catalog.

Mass and Reliability System (MaRS)

Science.gov (United States)

Barnes, Sarah

2016-01-01

The Safety and Mission Assurance (S&MA) Directorate is responsible for mitigating risk, providing system safety, and lowering risk for space programs from ground to space. The S&MA is divided into 4 divisions: The Space Exploration Division (NC), the International Space Station Division (NE), the Safety & Test Operations Division (NS), and the Quality and Flight Equipment Division (NT). The interns, myself and Arun Aruljothi, will be working with the Risk & Reliability Analysis Branch under the NC Division's. The mission of this division is to identify, characterize, diminish, and communicate risk by implementing an efficient and effective assurance model. The team utilizes Reliability and Maintainability (R&M) and Probabilistic Risk Assessment (PRA) to ensure decisions concerning risks are informed, vehicles are safe and reliable, and program/project requirements are realistic and realized. This project pertains to the Orion mission, so it is geared toward a long duration Human Space Flight Program(s). For space missions, payload is a critical concept; balancing what hardware can be replaced by components verse by Orbital Replacement Units (ORU) or subassemblies is key. For this effort a database was created that combines mass and reliability data, called Mass and Reliability System or MaRS. The U.S. International Space Station (ISS) components are used as reference parts in the MaRS database. Using ISS components as a platform is beneficial because of the historical context and the environment similarities to a space flight mission. MaRS uses a combination of systems: International Space Station PART for failure data, Vehicle Master Database (VMDB) for ORU & components, Maintenance & Analysis Data Set (MADS) for operation hours and other pertinent data, & Hardware History Retrieval System (HHRS) for unit weights. MaRS is populated using a Visual Basic Application. Once populated, the excel spreadsheet is comprised of information on ISS components including

Millennium Ecosystem Assessment: MA Ecosystems

Data.gov (United States)

National Aeronautics and Space Administration — The Millennium Ecosystem Assessment: MA Ecosystems provides data and information on the extent and classification of ecosystems circa 2000, including coastal,...

Millennium Ecosystem Assessment: MA Biodiversity

Data.gov (United States)

National Aeronautics and Space Administration — The Millennium Ecosystem Assessment: MA Biodiversity provides data and information on amphibians, disease agents (extent and distribution of infectious and parasitic...

46 CFR 308.545 - Facultative cargo policy, Form MA-316.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Facultative cargo policy, Form MA-316. 308.545 Section 308.545 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK... policy, Form MA-316. The standard form of War Risk Facultative Cargo Policy, Form MA-316, may be obtained...

M&A information technology best practices

CERN Document Server

Roehl-Anderson, Janice M

2013-01-01

Add value to your organization via the mergers & acquisitions IT function  As part of Deloitte Consulting, one of the largest mergers and acquisitions (M&A) consulting practice in the world, author Janice Roehl-Anderson reveals in M&A Information Technology Best Practices how companies can effectively and efficiently address the IT aspects of mergers, acquisitions, and divestitures. Filled with best practices for implementing and maintaining systems, this book helps financial and technology executives in every field to add value to their mergers, acquisitions, and/or divestitures via the IT

42 CFR 422.4 - Types of MA plans.

Science.gov (United States)

2010-10-01

... availability, service area, and quality. (ii) Coordinated care plans may include mechanisms to control... requirements of sections 138 and 220 of the Internal Revenue Code. (3) MA private fee-for-service plan. An MA... Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

Ma(d)skulinitet

DEFF Research Database (Denmark)

Leer, Jonatan

Når tv-kokke som Jamie Oliver, Gordon Ramsay og brødrene Price toner frem på skærmen, laver de ikke kun mad. De mixer også maskulinitet. For når en mand laver mad, laver maden også manden. Det mener postdoc Jonatan Leer, der i Ma(ds)kulinitet. Kønskamp i tv-køkkenet præsenterer, hvordan og hvorfor...

HoCaMA: Home Care Hybrid Multiagent Architecture

Science.gov (United States)

Fraile, Juan A.; Bajo, Javier; Abraham, Ajith; Corchado, Juan M.

Home Care is one of the main objectives of Ambient Intelligence. Nowadays, the disabled and elderly population, which represents a significant part of our society, requires novel solutions for providing home care in an effective way. In this chapter, we present HoCaMA, a hybrid multiagent architecture that facilitates remote monitoring and care services for disabled patients at their homes. HoCaMA combines multiagent systems and Web services to facilitate the communication and integration with multiple health care systems. In addition, HoCaMA focuses on the design of reactive agents capable of interacting with different sensors present in the environment, and incorporates a system of alerts through SMS and MMS mobile technologies. Finally, it uses Radio Frequency IDentification and JavaCard technologies to provide advanced location and identification systems, as well as automatic access control facilities. HoCaMA has been implemented in a real environment and the results obtained are presented within this chapter.

Synthesis of Novel Temperature- and pH-Sensitive ABA Triblock Copolymers P(DEAEMA-co-MEO2MA-co-OEGMA-b-PEG-b-P(DEAEMA-co-MEO2MA-co-OEGMA: Micellization, Sol–Gel Transitions, and Sustained BSA Release

Directory of Open Access Journals (Sweden)

Yanan Han

2016-11-01

Full Text Available Novel temperature- and pH-responsive ABA-type triblock copolymers, P(DEAEMA-co-MEO2MA-co-OEGMA-b-PEG-b-P(DEAEMA-co-MEO2MA-co-OEGMA, composed of a poly(ethylene glycol (PEG middle block and temperature- and pH-sensitive outer blocks, were synthesized by atom transfer radical polymerization (ATRP. The composition and structure of the copolymer were characterized by 1H NMR and gel permeation chromatography (GPC. The temperature- and pH-sensitivity, micellization, and the sol–gel transitions of the triblock copolymers in aqueous solutions were studied using transmittance measurements, surface tension, viscosity, fluorescence probe technique, dynamic light scattering (DLS, zeta-potential measurements, and transmission electron microscopy (TEM. The lower critical solution temperature (LCST of the triblock copolymer, which contains a small amount of a weak base group, (N,N-diethylamino ethyl methacrylate (DEAEMA, can be tuned precisely and reversibly by changing the solution pH. When the copolymer concentration was sufficiently high, increasing temperature resulted in the free-flowing solution transformation into a micellar gel. The sol-to-gel transition temperature (Tsol–gel in aqueous solution will continue to decrease as solution concentration increases.

Millennium Ecosystem Assessment: MA Population

Data.gov (United States)

National Aeronautics and Space Administration — The Millennium Ecosystem Assessment: MA Population data sets provide baseline population information as one of the drivers of ecosystem change. The data helped in...

Microcap M&A: An Exploratory Study

Directory of Open Access Journals (Sweden)

Keith Turpie

2014-06-01

Full Text Available A substantial body of accounting and finance literature has been devoted to the study of Mergers and Acquisitions (M&As dominated by discussions relating to the gains and losses that accrue from transactions involving large public companies. This paper makes a unique contribution to the literature by investigating the M&A experience of microcap businesses. Transactions involving microcap M&A are substantially different to those involving large companies on a number of dimensions. This paper explores the determinants of microcap M&A success and pitfalls and problems from an integration perspective. Due to the paucity of research in the area an exploratory research design is employed, conducting interviews with five CEOs of companies that had each managed multiple transactions. We find microcap M&As are successful when measured against identified goals but generally take longer and cost more than expected. Further, culture and communication are key issues in determining success/failure. We also find the in-house management of integration aspects is problematic for these businesses and suggest this warrants further study.

46 CFR 308.517 - Open Cargo Policy, Form MA-300.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Open Cargo Policy, Form MA-300. 308.517 Section 308.517... Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War Risk...

Turbulent convection in an anelastic rotating sphere: A model for the circulation on the giant planets

Science.gov (United States)

Kaspi, Yohai

vorticity gradient is in the opposite direction, due to the spherical geometry in the interior. We further study these interior dynamics using a simplified barotropic annulus model, which shows that the planetary vorticity radial variation causes the eddy angular momentum flux divergence, which drives the superrotating equatorial flow. In addition we study the interaction of the interior dynamics with a stable exterior weather layer, using a quasigeostrophic two layer channel model on a beta plane, where the columnar interior is therefore represented by a negative beta effect. We find that baroclinic instability of even a weak shear can drive strong, stable multiple zonal jets. For this model we find an analytic nonlinear solution, truncated to one growing mode, that exhibits a multiple jet meridional structure, driven by the nonlinear interaction between the eddies. Finally, given the density field from our 3D convection model we derive the high order gravitational spectra of Jupiter, which is a measurable quantity for the upcoming JUNO mission to Jupiter. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

Changing the S and MA [Safety and Mission Assurance] Paradigm

Science.gov (United States)

Malone, Roy W., Jr.

2010-01-01

Objectives: 1) Optimize S&MA organization to best facilitate Shuttle transition in 2010, successfully support Ares developmental responsibilities, and minimize the impacts of the gap between last Shuttle flight and start of Ares V Project. 2) Improve leveraging of critical skills and experience between Shuttle and Ares. 3) Split technical and supervisory functions to facilitate technical penetration. 4) Create Chief Safety and Mission Assurance Officer (CSO) stand-alone position for successfully implementation of S&MA Technical Authority. 5) Minimize disruption to customers. 6) Provide early involvement of S&MA leadership team and frequent/open communications with S&MA team members and steak-holders.

FİLMLERLE İLETİŞİM VE YABANCILAŞMA

OpenAIRE

ÖZTÜRK, Serdar

2018-01-01

Yabancılaşma konusu genellikle iktisadi, sosyolojik ve psikoloji boyutlarıyla tartışılmıştır. Oysa bir anlam paylaşımı olarak iletişim, yabancılaşmayla doğrudan ilişkilidir. Buna karşın iletişim ile yabancılaşma ilişkisini, analize filmleri de katarak inceleyen çok az çalışma bulunmaktadır. Bu çalışma, yabancılaşma kavramını tartışarak, yabancılaşmanın iletişim ile ilişkisini incelemektedir. Buna göre insanın kendi ürettiği sembollerine, medyanın üretim bölgesinde üretilen sembollere yabancıl...

Regioselective hydroxylation of isoflavones by Streptomyces avermitilis MA-4680.

Science.gov (United States)

Roh, Changhyun; Seo, Su-Hyun; Choi, Kwon-Young; Cha, Minho; Pandey, Bishnu Prasad; Kim, June-Hyung; Park, Jun-Seong; Kim, Duck Hee; Chang, Ih Seop; Kim, Byung-Gee

2009-07-01

Screening of bacterial whole cells was performed for regioselective hydroxylation of daidzein and genistein. Among the strains examined, Streptomyces avermitilis MA-4680 showed high ortho-dihydroxylation activity to produce 3',4',7-trihydroxyisoflavone and 3',4',5,7-tetrahydroxyisoflavone from daidzein (4',7-dihydroxyisoflavone) and genistein (4',5,7-trihydroxyisoflavone), respectively. Using 100 mg cells (wet wt.) and 1% (v/v) Triton X100 in 1 ml of total reaction volume, where 100 microl of the substrate solution (0.5 mM in 10% (v/v) mixed solvent of DMSO:MeOH = 3:7) was added to 900 microl of potassium phosphate buffer (100 mM, pH 7.2), a 16% molar conversion yield of 3',4',7-trihydroxyisoflavone was obtained from 0.5 mM daidzein after 24 h of reaction time at 28 degrees C and 200 rpm. Ketoconazole significantly (ca. 90%) inhibited the ortho-hydroxylation activity of daidzein, suggesting that cytochrome P450 enzymes putatively play roles in regiospecific daidzein hydroxylation. The analysis of the reaction products was determined by gas chromatography/mass spectrometry (GC/MS) and (1)H NMR.

Reconstruction of pH and partial pressure of carbon dioxide during the Mesozoic era period using boron and oxygen isotopic compositions of fresh ammonoids & nautiloids

Science.gov (United States)

Kawahata, Hodaka; Fukushima, Ayaka; Moriya, Kazuyori; Ishikawa, Tsuyoshi; Suzuki, Atsushi; Tanabe, Kazushige

2013-04-01

The increase of partial pressure of carbon dioxide (pCO2) in the atmosphere induces global warming and ocean acidification at the modern condition. The reconstruction of pCO2 during the geological time is required together with proxy calibration by laboratory experiments to predict the future environments. Boron isotopic ratio is an excellent proxy for pH and the relevant partial pressure of carbon dioxide in the seawater (PCO2). This study is the first to quantify pH dependence of delta 11B of the ammonoids and nautiloids mainly in the Cretaceous and in Jurassic (70-162 Ma), which are expected to be much warmer due to higher PCO2. However, no reliable reconstruction data using foraminiferal delta 11B before Cenozoic era has been reported. We used the very fresh aragonite shells of ammonoids and nautiloids by big advantages. Since aragonite changes into secondary calcite by diagenesis, it is easy and effective to identify the degree of alteration at each sample by measuring calcite/aragonite ratio. Also we carefully conducted the assessment of secondary alteration from three perspectives: 1) Determination of calcite/aragonite ratio by X-ray diffraction (XRD), 2) Observation of microstructures of the nacreous layers by scanning electron microscope (SEM), and 3) Measurement of trace element contents and stable isotope ratios. We conducted high precision boron isotope analysis of biogenic carbonates with +/- 0.1 per mil reproducibility by adopting positive thermal ionization mass spectrometry (P-TIMS) methods. Also we analyzed delta 18O to estimate paleo-temperature, at which biogenic aragonite was formed. Combination of delta 11B and delta 18O of biogenic aragonite in 80 Ma and 86 Ma revealed that deeper dwellers showed lower delta 11B values, which corresponded to lower pH. This feature is consistent with those observed in the modern vertical water column. The respective shallow water temperature was 19.7 and 19.1 centigrade. Based on these results, the

Gate less-FET pH Sensor Fabricated on Undoped AlGaN/ GaN HEMT Structure

International Nuclear Information System (INIS)

Maneea Eizadi Sharifabad; Mastura Shafinaz Zainal Abidin; Shaharin Fadzli Abd Rahman; Abdul Manaf Hashim; Abdul Rahim Abdul Rahman

2011-01-01

Gallium nitride with wurtzite crystal structure is a chemically stable semiconductor with high internal spontaneous and piezoelectric polarization, which make it highly suitable materials to create very sensitive and robust sensors for the detection of ions, gases and liquids. Sensing characteristics of an open-gate liquid-phase sensor fabricated on undoped-AlGaN/ GaN high-electron-mobility-transistor (HEMT) structure in aqueous solution was investigated. In ambient atmosphere, the open-gate undoped AlGaN/ GaN HEMT clearly showed only the presence of linear region of currents while Si-doped AlGaN/ GaN showed the linear and saturation regions of currents, very similar to those of gated devices. This seems to show that very low Fermi level pinning by surface states exists in undoped AlGaN/ GaN sample. In aqueous solution, the typical current-voltage (I-V) characteristics of HEMTs with good gate controllability were observed. The potential of the AlGaN surface at the open-gate area is effectively controlled via aqueous solution by Ag/ AgCl reference gate electrode. The open-gate undoped AlGaN/ GaN HEMT structure is capable of stable operation in aqueous electrolytes and exhibit linear sensitivity, and high sensitivity of 1.9 mA/ pH or 3.88 mA/ mm/ pH at drain-source voltage, VDS = 5 V was obtained. Due to large leakage current where it increases with the negative reference gate voltage, the Nernstians like sensitivity cannot be determined. Suppression of current leakage is likely to improve the device performance. The open-gate undoped-AlGaN/ GaN structure is expected to be suitable for pH sensing application. (author)

Alumni careers : MA Comparative European Social Studies Zuyd University

OpenAIRE

Riga, Albert

2004-01-01

In the preparation of the celebration of the 10th anniversary of the MA CESS all alumni were invited to participate in an alumni survey. The purpose of the survey was to thoroughly investigate the professional activities of MA CESS alumni and the way they build an alumni community. Another reason for starting the project is that it may play a part in maintaining and enhancing a mutually beneficial relationship between MA CESS and its alumni. All over Europe there are graduates working in the ...

Cell cycle-dependent SUMO-1 conjugation to nuclear mitotic apparatus protein (NuMA)

Energy Technology Data Exchange (ETDEWEB)

Seo, Jae Sung; Kim, Ha Na; Kim, Sun-Jick; Bang, Jiyoung; Kim, Eun-A; Sung, Ki Sa [Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746 (Korea, Republic of); Yoon, Hyun-Joo [TissueGene Inc. 9605 Medical Center Dr., Rockville, MD 20850 (United States); Yoo, Hae Yong [Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Samsung Medical Center, Sungkyunkwan University, Seoul 135-710 (Korea, Republic of); Choi, Cheol Yong, E-mail: choicy@skku.ac.kr [Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746 (Korea, Republic of)

2014-01-03

Highlights: •NuMA is modified by SUMO-1 in a cell cycle-dependent manner. •NuMA lysine 1766 is the primary target site for SUMOylation. •SUMOylation-deficient NuMA induces multiple spindle poles during mitosis. •SUMOylated NuMA induces microtubule bundling. -- Abstract: Covalent conjugation of proteins with small ubiquitin-like modifier 1 (SUMO-1) plays a critical role in a variety of cellular functions including cell cycle control, replication, and transcriptional regulation. Nuclear mitotic apparatus protein (NuMA) localizes to spindle poles during mitosis, and is an essential component in the formation and maintenance of mitotic spindle poles. Here we show that NuMA is a target for covalent conjugation to SUMO-1. We find that the lysine 1766 residue is the primary NuMA acceptor site for SUMO-1 conjugation. Interestingly, SUMO modification of endogenous NuMA occurs at the entry into mitosis and this modification is reversed after exiting from mitosis. Knockdown of Ubc9 or forced expression of SENP1 results in impairment of the localization of NuMA to mitotic spindle poles during mitosis. The SUMOylation-deficient NuMA mutant is defective in microtubule bundling, and multiple spindles are induced during mitosis. The mitosis-dependent dynamic SUMO-1 modification of NuMA might contribute to NuMA-mediated formation and maintenance of mitotic spindle poles during mitosis.

Ordered photonic microstructures

Science.gov (United States)

Chen, Kevin Ming

2001-09-01

polystyrene latex colloidal particles into 2D crystals is presented. The colloidal assemblies offer a relatively easy processing route for fabrication of photonic bandgap structures. Large (>1 mm diameter) single crystal grains of colloids were formed using controlled evaporation and fluid flow techniques. A novel solution enabling post-processing of the fragile ordered assemblies is presented in which polyelectrolyte multilayers serve as adsorption platforms that anchor the colloidal assemblies. Tailorability of the polyelectrolyte surface properties (charge density, morphology) enables tuning of the colloid adsorption behavior. The polyelectrolyte surface affects colloid adsorption by influencing its surface diffusion. Observations of colloid surface diffusion were made using optical microscopy. Use of polyelectrolytes patterned via microcontact printing enables fabrication of colloid assemblies containing predesigned point and line defects. The patterned polyelectrolyte adsorption template allows placement of colloids in specific geometric arrangement, making possible the realization of sensors or functional photonic bandgap devices such as waveguides or photon traps. Three mechanisms were used to control adsorption: (1)pH of the colloid suspension, which determines the ionization of the uppermost surface of the polyelectrolyte multilayer; (2)ionic strength of the suspension, which determines the extent of charge screening about the colloid and polyelectrolyte; and (3)concentration of added surfactant, which causes charge screening and introduces hydrophobic interactions between the surfactant and polyelectrolyte. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253- 1690.)

MaGate Simulator: A Simulation Environment for a Decentralized Grid Scheduler

Science.gov (United States)

Huang, Ye; Brocco, Amos; Courant, Michele; Hirsbrunner, Beat; Kuonen, Pierre

This paper presents a simulator for of a decentralized modular grid scheduler named MaGate. MaGate’s design emphasizes scheduler interoperability by providing intelligent scheduling serving the grid community as a whole. Each MaGate scheduler instance is able to deal with dynamic scheduling conditions, with continuously arriving grid jobs. Received jobs are either allocated on local resources, or delegated to other MaGates for remote execution. The proposed MaGate simulator is based on GridSim toolkit and Alea simulator, and abstracts the features and behaviors of complex fundamental grid elements, such as grid jobs, grid resources, and grid users. Simulation of scheduling tasks is supported by a grid network overlay simulator executing distributed ant-based swarm intelligence algorithms to provide services such as group communication and resource discovery. For evaluation, a comparison of behaviors of different collaborative policies among a community of MaGates is provided. Results support the use of the proposed approach as a functional ready grid scheduler simulator.

Experimental Physical Sciences Vistas: MaRIE (draft)

Energy Technology Data Exchange (ETDEWEB)

Shlachter, Jack [Los Alamos National Laboratory

2010-09-08

To achieve breakthrough scientific discoveries in the 21st century, a convergence and integration of world-leading experimental facilities and capabilities with theory, modeling, and simulation is necessary. In this issue of Experimental Physical Sciences Vistas, I am excited to present our plans for Los Alamos National Laboratory's future flagship experimental facility, MaRIE (Matter-Radiation Interactions in Extremes). MaRIE is a facility that will provide transformational understanding of matter in extreme conditions required to reduce or resolve key weapons performance uncertainties, develop the materials needed for advanced energy systems, and transform our ability to create materials by design. Our unique role in materials science starting with the Manhattan Project has positioned us well to develop a contemporary materials strategy pushing the frontiers of controlled functionality - the design and tailoring of a material for the unique demands of a specific application. Controlled functionality requires improvement in understanding of the structure and properties of materials in order to synthesize and process materials with unique characteristics. In the nuclear weapons program today, improving data and models to increase confidence in the stockpile can take years from concept to new knowledge. Our goal with MaRIE is to accelerate this process by enhancing predictive capability - the ability to compute a priori the observables of an experiment or test and pertinent confidence intervals using verified and validated simulation tools. It is a science-based approach that includes the use of advanced experimental tools, theoretical models, and multi-physics codes, simultaneously dealing with multiple aspects of physical operation of a system that are needed to develop an increasingly mature predictive capability. This same approach is needed to accelerate improvements to other systems such as nuclear reactors. MaRIE will be valuable to many national

Performance during post-harvest storage of banana cv. 'prata', 'maçã' and 'nanica' exposed to physical and chemical treatments Comportamento pós-colheita durante armazenamento de bananas 'prata', 'maçã' e 'nanica' submetidas a tratamentos físicos e químicos

Directory of Open Access Journals (Sweden)

Silvia R. M. Coelho

2011-01-01

Full Text Available Banana is the most consumed fruit in the world and Brazil is the second largest producer. Despite its global position, Brazil has an average of 40% losses during the post-harvest period. So, this experiment aimed at evaluating the efficiency of post-harvest treatments to improve the storage of banana cultivars cv. 'Prata', 'Maçã' and 'Nanica'. The fruits were acquired at CEASA with green peel, and were submitted to six different treatments: T- immersion in drinking water for 3 minutes (control, H3 - hot water (50 °C for 3 minutes, H8 - hot water (50 °C for 8 minutes, HP - immersion in hypochlorite 0.2% for 3 minutes, OS - immersion in soybean oil 10% for 3 minutes, and OM - immersion in mineral oil 10% for 3 minutes. The fruits were stored at room temperature at about 21 °C for 14 days and evaluated in three periods (1, 7 and 14 days comparing peel color, flesh/peel ratio, titratable acidity (TA, soluble solids (SS, SS/TA ratio, and pH. The fruits of cv. 'Prata' and 'Maçã' submitted to the treatments H3, H8 and HP ripened at the same time as the control for peel color, which showed increased soluble solids, flesh/peel ratio, acidity and a decrease in pH. On the other hand, the cv. 'Nanica' did not respond significantly different when compared to the applied treatments and the control. The fruits treated with OM and OS were kept green for a longer time for the cultivars 'Prata' and 'Nanica', but there were some changes on peel color due dark spots in 'Prata' banana and a softening aspect in 'Nanica', indicating some level of toxicity of these treatments. Fruits of the 'Maçã' cultivar continued green with the application of mineral oil, without toxicity symptoms. In conclusion, the treatments applied did not show any advantage for storage of these fruits.A banana é a fruta mais consumida no mundo, e o Brasil é o segundo maior produtor mundial. Apesar de seu ranking mundial, apresenta níveis de até 40% de perdas no período p

Texture and anisotropy of the mechanical properties of MA14 and MA2-1 alloys produced by granular metallurgy

Science.gov (United States)

Betsofen, S. Ya.; Konkevich, V. Yu.; Osintsev, O. E.; Avdyukhina, A. A.; Voskresenskaya, I. I.; Grushin, I. A.

2015-10-01

The contribution of texture to the anisotropy of the mechanical properties of semifinished products from MA14 and MA2-1 alloys prepared by capsule-free pressing of granules is quantitatively evaluated using inverse pole figures and calculated Taylor orientation factors for basal slip. It is shown that the texture intensity and the anisotropy of the mechanical properties of the pressed semiproducts are lower than those of the semiproducts from an ingot and the compressive yield strength is substantially higher.

Model for Analysis of Energy Demand (MAED-2). User's manual

International Nuclear Information System (INIS)

2007-01-01

The IAEA has been supporting its Member States in the area of energy planning for sustainable development. Development and dissemination of appropriate methodologies and their computer codes are important parts of this support. This manual has been produced to facilitate the use of the MAED model: Model for Analysis of Energy Demand. The methodology of the MAED model was originally developed by. B. Chateau and B. Lapillonne of the Institute Economique et Juridique de l'Energie (IEJE) of the University of Grenoble, France, and was presented as the MEDEE model. Since then the MEDEE model has been developed and adopted to be appropriate for modelling of various energy demand system. The IAEA adopted MEDEE-2 model and incorporated important modifications to make it more suitable for application in the developing countries, and it was named as the MAED model. The first version of the MAED model was designed for the DOS based system, which was later on converted for the Windows system. This manual presents the latest version of the MAED model. The most prominent feature of this version is its flexibility for representing structure of energy consumption. The model now allows country-specific representations of energy consumption patterns using the MAED methodology. The user can now disaggregate energy consumption according to the needs and/or data availability in her/his country. As such, MAED has now become a powerful tool for modelling widely diverse energy consumption patterns. This manual presents the model in details and provides guidelines for its application

Model for Analysis of Energy Demand (MAED-2). User's manual

International Nuclear Information System (INIS)

2006-01-01

The IAEA has been supporting its Member States in the area of energy planning for sustainable development. Development and dissemination of appropriate methodologies and their computer codes are important parts of this support. This manual has been produced to facilitate the use of the MAED model: Model for Analysis of Energy Demand. The methodology of the MAED model was originally developed by. B. Chateau and B. Lapillonne of the Institute Economique et Juridique de l'Energie (IEJE) of the University of Grenoble, France, and was presented as the MEDEE model. Since then the MEDEE model has been developed and adopted to be appropriate for modelling of various energy demand system. The IAEA adopted MEDEE-2 model and incorporated important modifications to make it more suitable for application in the developing countries, and it was named as the MAED model. The first version of the MAED model was designed for the DOS based system, which was later on converted for the Windows system. This manual presents the latest version of the MAED model. The most prominent feature of this version is its flexibility for representing structure of energy consumption. The model now allows country-specific representations of energy consumption patterns using the MAED methodology. The user can now disaggregate energy consumption according to the needs and/or data availability in her/his country. As such, MAED has now become a powerful tool for modelling widely diverse energy consumption patterns. This manual presents the model in details and provides guidelines for its application

Large area imaging of forensic evidence with MA-XRF.

Science.gov (United States)

Langstraat, Kirsten; Knijnenberg, Alwin; Edelman, Gerda; van de Merwe, Linda; van Loon, Annelies; Dik, Joris; van Asten, Arian

2017-11-08

This study introduces the use of macroscopic X-ray fluorescence (MA-XRF) for the detection, classification and imaging of forensic traces over large object areas such as entire pieces of clothing and wall paneling. MA-XRF was sufficiently sensitive and selective to detect human biological traces like blood, semen, saliva, sweat and urine on fabric on the basis of Fe, Zn, K, Cl and Ca elemental signatures. With MA-XRF a new chemical contrast is introduced for human stain detection and this can provide a valuable alternative when the evidence item is challenging for conventional techniques. MA-XRF was also successfully employed for the chemical imaging and classification of gunshot residues (GSR). The full and non-invasive elemental mapping (Pb, Ba, Sr, K and Cl) of intact pieces of clothing allows for a detailed shooting incident reconstruction linking firearms and ammunition to point of impact and providing information on the shooting angle. In high resolution mode MA-XRF can even be used to provide information on the shooting order of different ammunition types. Finally, by using the surface penetration of X-rays we demonstrate that the lead signature of a bullet impact can be easily detected even if covered by multiple layers of wall paint or human blood.

Large area imaging of forensic evidence with MA-XRF

NARCIS (Netherlands)

Langstraat, K.; Knijnenberg, A.; Edelman, G.; van de Merwe, L.; van Loon, A.; Dik, J.; van Asten, A.

2017-01-01

This study introduces the use of macroscopic X-ray fluorescence (MA-XRF) for the detection, classification and imaging of forensic traces over large object areas such as entire pieces of clothing and wall paneling. MA-XRF was sufficiently sensitive and selective to detect human biological traces

Large area imaging of forensic evidence with MA-XRF

NARCIS (Netherlands)

Langstraat, Kirsten; Knijnenberg, Alwin; Edelman, Gerda; Van De Merwe, Linda; van Loon, A.; Dik, J.; van Asten, Arian C.

2017-01-01

This study introduces the use of macroscopic X-ray fluorescence (MA-XRF) for the detection, classification and imaging of forensic traces over large object areas such as entire pieces of clothing and wall paneling. MA-XRF was sufficiently sensitive and selective to detect human biological traces

Publisher Correction: Optimal compressed representation of high throughput sequence data via light assembly.

Science.gov (United States)

Ginart, Antonio A; Hui, Joseph; Zhu, Kaiyuan; Numanagić, Ibrahim; Courtade, Thomas A; Sahinalp, S Cenk; Tse, David N

2018-04-26

The original version of this Article contained errors in the affiliations of the authors Ibrahim Numanagić and Thomas A. Courtade, which were incorrectly given as 'Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720, USA' and 'Computer Science & Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA', respectively. Also, the hyperlink for the source code in the Data Availability section was incorrectly given as https://github.iu.edu/kzhu/assembltrie , which links to a page that is not publicly accessible. The source code is publicly accessible at https://github.com/kyzhu/assembltrie . Furthermore, in the PDF version of the Article, the right-hand side of Figure 3 was inadvertently cropped. These errors have now been corrected in both the PDF and HTML versions of the Article.

Separation of minor actinides from a genuine MA/LN fraction

International Nuclear Information System (INIS)

Satmark, B.; Courson, O.; Malmbeck, R.; Pagliosa, G.; Romer, K.; Glatz, J.P.

2001-01-01

Separation of the trivalent Minor Actinides (MA), Am and Cm, has been performed from a genuine MA(III) + Ln(III) solution using Bis-Triazine-Pyridine (BTP) as organic extractant. The representative MA/Ln fraction was obtained from a dissolved commercial LWR fuel (45.2 GWd/tM) submitted subsequently too a PUREX process followed by a DIAMEX process. A centrifugal extractor set-up (16-stages), working in a continuous counter-current mode, was used for the liquid-liquid separation. In the nPr-BTP process, feed decontamination factors for Am and Cm above 96 and 65, respectively were achieved. The back-extraction was more efficient for Am (99.1% recovery) than for Cm (97.5%). This experiment, using the Bis-Triazine-Pyridine molecule is the first successful demonstration of the separation of MA from lanthanides in a genuine MA/Ln fraction with a nitric acid concentration of ca. 1 M. It represents an important break through in the difficult field of minor actinide partitioning of high level liquid waste. (author)

Diet of Theropithecus from 4 to 1 Ma in Kenya.

Science.gov (United States)

Cerling, Thure E; Chritz, Kendra L; Jablonski, Nina G; Leakey, Meave G; Manthi, Fredrick Kyalo

2013-06-25

Theropithecus was a common large-bodied primate that co-occurred with hominins in many Plio-Pleistocene deposits in East and South Africa. Stable isotope analyses of tooth enamel from T. brumpti (4.0-2.5 Ma) and T. oswaldi (2.0-1.0 Ma) in Kenya show that the earliest Theropithecus at 4 Ma had a diet dominated by C4 resources. Progressively, this genus increased the proportion of C4-derived resources in its diet and by 1.0 Ma, had a diet that was nearly 100% C4-derived. It is likely that this diet was comprised of grasses or sedges; stable isotopes cannot, by themselves, give an indication of the relative importance of leaves, seeds, or underground storage organs to the diet of this primate. Theropithecus throughout the 4- to 1-Ma time range has a diet that is more C4-based than contemporaneous hominins of the genera Australopithecus, Kenyanthropus, and Homo; however, Theropithecus and Paranthropus have similar proportions of C4-based resources in their respective diets.

Avatares tántricos de Râma

OpenAIRE

Muñoz, Adrián

2009-01-01

Si bien el poema épico del Râmâyana es considerado como uno de los pilares literarios del hinduismo, no se trata de un texto fijo, pues la trama ha generado diversas versiones alternas en el sur y el sureste asiáticos. Al mismo tiempo, aunque Râma representa ideales sociales fundamentales para la ortodoxia hinduista, otras corrientes religiosas no ortodoxas han recurrido a y adaptado la figura de Râma. Este ensayo busca valorar en particular las manifestaciones tántricas y pseudo-tántrica...

BaMa / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo, 1949-

2002-01-01

Eesti ülikoolide üleminekust 3+2 süsteemile. Lühend BaMa on tulnud kasutusele seoses Euroopa ülikoolide õppekavade reformimisega ning tähistab õppekava, kus esimese astme läbimise järel omandatakse bakalaureuse- ja teise järel magistrikraad. Õppekavade tüüpidest Eesti ja Euroopa Liidu kõrgkoolides ning Bologna deklaratsioonist

Impact of M&A on the Employment in Japanese Companies

OpenAIRE

Hiroyuki Taguchi; Taichi Yanagawa; Masashi Harita

2012-01-01

With utilizing Financial Statements Statistics of Corporation by Industry, we analyzed the impact of M&A on the employment in Japanese companies. In this study, the impact of M&A on the employment was extracted by developing panel data for fiscal year 1995 to 2008 targeting 9,880 sample companies including 3,697 cases of M&A to estimate a labor demand model. Major findings of the study are described below. First, dynamically positive effect was confirmed mainly in the manufacturing industry a...

Convective removal of the Tibetan Plateau mantle lithosphere by 26 Ma

Science.gov (United States)

Lu, Haijian; Tian, Xiaobo; Yun, Kun; Li, Haibing

2018-04-01

During the late Oligocene-early Miocene there were several major geological events in and around the Tibetan Plateau (TP). First, crustal shortening deformation ceased completely within the TP before 25 Ma and instead adakitic rocks and potassic-ultrapotassic volcanics were emplaced in the Lhasa terrane since 26-25 Ma. Several recent paleoelevation reconstructions suggest an Oligocene-early Miocene uplift of 1500-3000 m for the Qiangtang (QT) and Songpan-Ganzi (SG) terranes, although the exact timing is unclear. As a possible response to this uplift, significant desertification occurred in the vicinity of the TP at 26-22 Ma, and convergence between India and Eurasia slowed considerably at 26-20 Ma. Subsequently, E-W extension was initiated no later than 18 Ma in the Lhasa and QT terranes. In contrast, the tectonic deformation around the TP was dominated by radial expansion of shortening deformation since 25-22 Ma. The plateau-wide near-synchroneity of these events calls for an internally consistent model which can be best described as convective removal of the lower mantle lithosphere. Geophysical and petrochemical evidence further confirms that this extensive removal occurred beneath the QT and SG terranes. The present review concludes that, other than plate boundary stress, the internal stress within the TP lithosphere could have contributed to rapid wholesale uplift and a series of concomitant tectonic events, accompanied by major aridification, since 26 Ma.

Alumni careers : MA Comparative European Social Studies Zuyd University

NARCIS (Netherlands)

Albert Riga

2004-01-01

In the preparation of the celebration of the 10th anniversary of the MA CESS all alumni were invited to participate in an alumni survey. The purpose of the survey was to thoroughly investigate the professional activities of MA CESS alumni and the way they build an alumni community. Another reason

42 CFR 422.2268 - Standards for MA organization marketing.

Science.gov (United States)

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Standards for MA organization marketing. 422.2268 Section 422.2268 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Medicare Advantage Marketing Requirements § 422.2268 Standards for MA organizatio...

MaRGEE: Move and Rotate Google Earth Elements

Science.gov (United States)

Dordevic, Mladen M.; Whitmeyer, Steven J.

2015-12-01

Google Earth is recognized as a highly effective visualization tool for geospatial information. However, there remain serious limitations that have hindered its acceptance as a tool for research and education in the geosciences. One significant limitation is the inability to translate or rotate geometrical elements on the Google Earth virtual globe. Here we present a new JavaScript web application to "Move and Rotate Google Earth Elements" (MaRGEE). MaRGEE includes tools to simplify, translate, and rotate elements, add intermediate steps to a transposition, and batch process multiple transpositions. The transposition algorithm uses spherical geometry calculations, such as the haversine formula, to accurately reposition groups of points, paths, and polygons on the Google Earth globe without distortion. Due to the imminent deprecation of the Google Earth API and browser plugin, MaRGEE uses a Google Maps interface to facilitate and illustrate the transpositions. However, the inherent spatial distortions that result from the Google Maps Web Mercator projection are not apparent once the transposed elements are saved as a KML file and opened in Google Earth. Potential applications of the MaRGEE toolkit include tectonic reconstructions, the movements of glaciers or thrust sheets, and time-based animations of other large- and small-scale geologic processes.

Studiju programmas direktora informatīvā sistēma

OpenAIRE

Gūtmanis, Matīss

2012-01-01

Šajā kvalifikācijas darbā tiek izstrādāta atbalsta sistēma studiju programmas direktoram pamata informācijas glabāšanai. Sistēma tiek plānota kā tīmekļa lietotne, kas ir brīvi pieejama ikvienam. Lietotne ir izstrādāta izmantojot JAVA, HTML, JavaScript, MySQL tehnoloģijas. Sistēma paredzēta Latvijas Universitātes Datorikas Fakultātes programmu direktoriem.

Sesli Okuma ve Konuşma Prozodisi: İlişkisel Bir Çalışma

Directory of Open Access Journals (Sweden)

Hasan Keskin

2013-02-01

Full Text Available Bu araştırma,  ilköğretim dördüncü sınıf öğrencilerinin sesli okuma ve konuşma prozodileri arasındaki ilişkiyi incelemek amacıyla ilişkisel tarama modelinde yapılmıştır. Araştırmaya,  Konya ve Afyonkarahisar’da ilköğretim dördüncü sınıfa devam eden 50 öğrenci katılmıştır.  Öğrencilerin sesli okumaları ve konuşmaları video ile kayıt altına alınmış, daha sonra bu kayıtlar üzerinde ölçekler aracılığıyla puanlamalar yapılmıştır. Sesli okuma ve konuşma prozodisi arasındaki ilişkiyi belirlemeye yönelik, Pearson Momentler Çarpım Korelasyon Tekniği kullanılmıştır. Analiz sonuçlarına göre, öğrencilerin sesli okuma ve konuşma prozodileri arasında, pozitif yönlü orta düzeyde bir ilişki çıkmıştır. Öğrencilerin sesli okumaları ve konuşma prozodi puanları cinsiyet açısından ayrı ayrı incelenmiş; kız ve erkek öğrencilerin ortalamaları arasında anlamlı bir farklılık çıkmamıştır. Ayrıca, öğrencilerin sesli okuma ve konuşmalarındaki prozodik düzeyi belirlemeye yönelik ölçümler yapılmıştır. Bu ölçüm sonuçlarına göre, araştırmaya katılan öğrencilerin %52’sinin sesli okuma prozodilerinin,  %48’inin ise konuşma prozodilerinin düşük düzeyde olduğu görülmüştür.

Where is the happy Ending of Shāhnāma?

OpenAIRE

بهروز چمن آرا

2015-01-01

The renowned proverb “Shāhnāma axarash xoš ast” has implicit question which its answer may change our understanding of the nature and function of Shāhnāma. The end of Shāhnāma contains numerous tragic events in Sassanid age. Also it does not seem to be normal if the Iranians have deemed the bitter adventure of the Shahs and Pahlavāns as a happy ending like what Firdausi narrates at the end of his Shāhnāma. This article tries to reply the main question using an illustration on the story platfo...

Comprehensive analysis of NuMA variation in breast cancer

Directory of Open Access Journals (Sweden)

Aittomäki Kristiina

2008-03-01

Full Text Available Abstract Background A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with increased risk of breast cancer. Methods In order to evaluate the NuMa gene for breast cancer susceptibility, we have here screened the entire coding region and exon-intron boundaries of NuMa in 92 familial breast cancer patients and constructed haplotypes of the identified variants. Five missense variants were further screened in 341 breast cancer cases with a positive family history and 368 controls. We examined the frequency of Ala794Gly in an extensive series of familial (n = 910 and unselected (n = 884 breast cancer cases and controls (n = 906, with a high power to detect the suggested breast cancer risk. We also tested if the variant is associated with histopathologic features of breast tumors. Results Screening of NuMA resulted in identification of 11 exonic variants and 12 variants in introns or untranslated regions. Five missense variants that were further screened in breast cancer cases with a positive family history and controls, were each carried on a unique haplotype. None of the variants, or the haplotypes represented by them, was associated with breast cancer risk although due to low power in this analysis, very low risk alleles may go unrecognized. The NuMA Ala794Gly showed no difference in frequency in the unselected breast cancer case series or familial case series compared to control cases. Furthermore, Ala794Gly did not show any significant association with histopathologic characteristics of the tumors, though Ala794Gly was slightly more frequent among unselected cases with lymph node involvement. Conclusion Our results do not support the role of NuMA variants as breast cancer susceptibility alleles.

Comprehensive analysis of NuMA variation in breast cancer

International Nuclear Information System (INIS)

Kilpivaara, Outi; Rantanen, Matias; Tamminen, Anitta; Aittomäki, Kristiina; Blomqvist, Carl; Nevanlinna, Heli

2008-01-01

A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with increased risk of breast cancer. In order to evaluate the NuMa gene for breast cancer susceptibility, we have here screened the entire coding region and exon-intron boundaries of NuMa in 92 familial breast cancer patients and constructed haplotypes of the identified variants. Five missense variants were further screened in 341 breast cancer cases with a positive family history and 368 controls. We examined the frequency of Ala794Gly in an extensive series of familial (n = 910) and unselected (n = 884) breast cancer cases and controls (n = 906), with a high power to detect the suggested breast cancer risk. We also tested if the variant is associated with histopathologic features of breast tumors. Screening of NuMA resulted in identification of 11 exonic variants and 12 variants in introns or untranslated regions. Five missense variants that were further screened in breast cancer cases with a positive family history and controls, were each carried on a unique haplotype. None of the variants, or the haplotypes represented by them, was associated with breast cancer risk although due to low power in this analysis, very low risk alleles may go unrecognized. The NuMA Ala794Gly showed no difference in frequency in the unselected breast cancer case series or familial case series compared to control cases. Furthermore, Ala794Gly did not show any significant association with histopathologic characteristics of the tumors, though Ala794Gly was slightly more frequent among unselected cases with lymph node involvement. Our results do not support the role of NuMA variants as breast cancer susceptibility alleles

Dynamic regulation of gastric surface pH by luminal pH

OpenAIRE

Chu, Shaoyou; Tanaka, Shin; Kaunitz, Jonathan D.; Montrose, Marshall H.

1999-01-01

In vivo confocal imaging of the mucosal surface of rat stomach was used to measure pH noninvasively under the mucus gel layer while simultaneously imaging mucus gel thickness and tissue architecture. When tissue was superfused at pH 3, the 25 μm adjacent to the epithelial surface was relatively alkaline (pH 4.1 ± 0.1), and surface alkalinity was enhanced by topical dimethyl prostaglandin E2 (pH 4.8 ± 0.2). Luminal pH was changed from pH 3 to pH 5 to mimic the fasted-to-fed transition in intra...

"Sel kevadel olen ma eriti ilus..." : [luuletused] / Triin Soomets

Index Scriptorium Estoniae

Soomets, Triin

2003-01-01

Sisu: "Sel kevadel olen ma eriti ilus..." ; "Tahaksin teha midagi tõelist; midagi suurt..." ; "veebruaris on keha nii valge et syda läheb pahaks..." ; "kõige kohutavamad lepingud..." ; "Igal loojangul kutsun sind ja igal koidikul tõukan su ära..." ; "need hakid..." ; "Põhja vajudes on viimane asi, mida ma näen, rohelised sähvatused..."

Clinical analysis of anti-Ma2-associated encephalitis.

Science.gov (United States)

Dalmau, Josep; Graus, Francesc; Villarejo, Alberto; Posner, Jerome B; Blumenthal, Deborah; Thiessen, Brian; Saiz, Albert; Meneses, Patricio; Rosenfeld, Myrna R

2004-08-01

Increasing experience indicates that anti-Ma2-associated encephalitis differs from classical paraneoplastic limbic or brainstem encephalitis, and therefore may be unrecognized. To facilitate its diagnosis we report a comprehensive clinical analysis of 38 patients with anti-Ma2 encephalitis. Thirty-four (89%) patients presented with isolated or combined limbic, diencephalic or brainstem dysfunction, and four with other syndromes. Considering the clinical and MRI follow-up, 95% of the patients developed limbic, diencephalic or brainstem encephalopathy. Only 26% had classical limbic encephalitis. Excessive daytime sleepiness affected 32% of the patients, sometimes with narcolepsy-cataplexy and low CSF hypocretin. Additional hormonal or MRI abnormalities indicated diencephalic-hypothalamic involvement in 34% of the patients. Eye movement abnormalities were prominent in 92% of the patients with brainstem dysfunction, but those with additional limbic or diencephalic deficits were most affected; 60% of these patients had vertical gaze paresis that sometimes evolved to total external ophthalmoplegia. Three patients developed atypical parkinsonism, and two a severe hypokinetic syndrome with a tendency to eye closure and dramatic reduction of verbal output. Neurological symptoms preceded the tumour diagnosis in 62% of the patients. Brain MRI abnormalities were present in 74% of all patients and 89% of those with limbic or diencephalic dysfunction. Among the 34 patients with cancer, 53% had testicular germ-cell tumours. Two patients without evidence of cancer had testicular microcalcification and one cryptorchidism, risk factors for testicular germ-cell tumours. After neurological syndrome development, 17 of 33 patients received oncological treatment (nine also immunotherapy), 10 immunotherapy alone, and six no treatment. Overall, 33% of the patients had neurological improvement, three with complete recovery; 21% had long-term stabilization, and 46% deteriorated. Features

Construction of a high modulus asphalt (HiMA) trial section Ethekwini: South Africa's first practical experience with design, manufacturing and paving of HiMA

CSIR Research Space (South Africa)

Nkgapele, M

2012-07-01

Full Text Available A trial section was paved with the recently introduced High Modulus Asphalt (HiMA) technology on South Coast road in eThekwini (Durban). The trial section forms part of an effort to transfer HiMA technology to South Africa, in an initiative aimed...

Ma ma (2015. A reflection of the Spanish woman with breast cáncer

Directory of Open Access Journals (Sweden)

Clara PERALTA NUENO

2017-12-01

Full Text Available Ma ma (2015 is a Spanish drama film directed by Julio Medem and produced by Morena Films. This film tells the story of Magda’s life, whose character is interpreted by Penélope Cruz. After being diagnosed with a breast cancer, Magda, an unemployed teacher, will not know how to act nor how this disease will change her life. But little by little, she will bring into the surface all her vital energy. Breast cancer represents the most frequent type of cancer among women. Although the majority of the identified risk factors can be modified, the health systems focus on activities that let strengthen the primary prevention and activities of secondary and tertiary prevention. The early detection and the right treatment are essential to fight against this disease. The emotional process caused by the presence of cancer involves a mechanism of psychic reconstitution that allows the patient develop an answer to the organic, cognitive, social, and emotional challenges they have to deal with. This process is easier when they have a solid socio-family support network among other factors.

Orchiectomy for suspected microscopic tumor in patients with anti-Ma2-associated encephalitis.

Science.gov (United States)

Mathew, R M; Vandenberghe, R; Garcia-Merino, A; Yamamoto, T; Landolfi, J C; Rosenfeld, M R; Rossi, J E; Thiessen, B; Dropcho, E J; Dalmau, J

2007-03-20

To report the presence of microscopic neoplasms of the testis in men with anti-Ma2-associated encephalitis (Ma2-encephalitis) and to discuss the clinical implications. Orchiectomy specimens were examined using immunohistochemistry with Ma2 and Oct4 antibodies. Among 25 patients with Ma2-encephalitis younger than 50 years, 19 had germ-cell tumors, and 6 had no evidence of cancer. These 6 patients underwent orchiectomy because they fulfilled five criteria: 1) demonstration of anti-Ma2 antibodies in association with MRI or clinical features compatible with Ma2-encephalitis, 2) life-threatening or progressive neurologic deficits, 3) age Ma2 was expressed by neoplastic cells in three of three patients examined. Even though most patients had severe neurologic deficits at the time of orchiectomy (median progression of symptoms, 10 months), 4 had partial improvement and prolonged stabilization (8 to 84 months, median 22.5 months) and two did not improve after the procedure. In young men with Ma2-encephalitis, 1) the disorder should be attributed to a germ-cell neoplasm of the testis unless another Ma2-expressing tumor is found, 2) negative tumor markers, ultrasound, body CT, or PET do not exclude an intratubular germ-cell neoplasm of the testis, and 3) if no tumor is found, the presence of the five indicated criteria should prompt consideration of orchiectomy.

Development of a dispersion strengthened copper alloy using a MA-HIP method

Directory of Open Access Journals (Sweden)

T. Yamada

2016-12-01

Full Text Available A new Cu-Al alloy was fabricated by a MA-HIP method for application to the heat sink materials of divertors. With the increase in MA time, the grain size and Vickers hardness decreased and increased, respectively. At MA time of 32hrs, the hardness of the alloy was comparable to that of Glidcop® although the grain size was much larger. X-ray diffractometry, electrical resistivity measurements and STEM-EDS analyses suggested precipitation of Al-rich phase by MA for 32hrs followed by HIP.

Ma olin Saddami poeg / Latif Jahija

Index Scriptorium Estoniae

Jahija, Latif

1995-01-01

Järg Jan/21.,28. lk. 7,5. L. Jahija sensatsiooniline raamat "Ma olin Saddami poeg", milles ta pajatab kuidas ta a. 1987-1991 oli Iraagi presidendi vanema poja teisik. Lühikokkuvõte sellest jutustusest

y comercialización de maíz de Sinaloa

Directory of Open Access Journals (Sweden)

José Alberto García Salazar

2006-01-01

Full Text Available La política comercial instrumentada por el Gobierno de México dirigida al mercado de maíz se ha caracterizado por la autorización de importaciones libres de arancel superiores a la cuota establecida en el Tratado de Libre Comercio de América del Norte. Con el objetivo de analizar cómo esta política podría afectar la comercialización de la producción de maíz de Sinaloa, se usó un modelo de distribución de la producción del grano que incorpora características espaciales e intertemporales. Los resultados indican que si el consumo nacional real de maíz fuera menor en 10%, respecto al consumo nacional aparente, las mayores importaciones determinarían que 954 mil toneladas de la producción de la entidad no pudrían comercializarse. Debido a que esta situación resta competitividad al productor de maíz, puesto que la producción no comercializada tiene que almacenarse, los productores sinaloenses deberán estar pendientes y vigilar las decisiones del Gobierno en materia de cupos de importación de maíz.

46 CFR 308.306 - Second Seamen's War Risk Policy, Form MA-242.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Second Seamen's War Risk Policy, Form MA-242. 308.306... RISK INSURANCE Second Seamen's War Risk Insurance § 308.306 Second Seamen's War Risk Policy, Form MA-242. (a) The standard form of Second Seamen's War Risk Policy Form MA-242, may be obtained from the...

Optimization of urinary dipstick pH: Are multiple dipstick pH readings reliably comparable to commercial 24-hour urinary pH?

Science.gov (United States)

Abbott, Joel E; Miller, Daniel L; Shi, William; Wenzler, David; Elkhoury, Fuad F; Patel, Nishant D; Sur, Roger L

2017-09-01

Accurate measurement of pH is necessary to guide medical management of nephrolithiasis. Urinary dipsticks offer a convenient method to measure pH, but prior studies have only assessed the accuracy of a single, spot dipstick. Given the known diurnal variation in pH, a single dipstick pH is unlikely to reflect the average daily urinary pH. Our goal was to determine whether multiple dipstick pH readings would be reliably comparable to pH from a 24-hour urine analysis. Kidney stone patients undergoing a 24-hour urine collection were enrolled and took images of dipsticks from their first 3 voids concurrently with the 24-hour collection. Images were sent to and read by a study investigator. The individual and mean pH from the dipsticks were compared to the 24-hour urine pH and considered to be accurate if the dipstick readings were within 0.5 of the 24-hour urine pH. The Bland-Altman test of agreement was used to further compare dipstick pH relative to 24-hour urine pH. Fifty-nine percent of patients had mean urinary pH values within 0.5 pH units of their 24-hour urine pH. Bland-Altman analysis showed a mean difference between dipstick pH and 24-hour urine pH of -0.22, with an upper limit of agreement of 1.02 (95% confidence interval [CI], 0.45-1.59) and a lower limit of agreement of -1.47 (95% CI, -2.04 to -0.90). We concluded that urinary dipstick based pH measurement lacks the precision required to guide medical management of nephrolithiasis and physicians should use 24-hour urine analysis to base their metabolic therapy.

Poly methacrylic acid modified CDHA nanocomposites as potential pH responsive drug delivery vehicles.

Science.gov (United States)

Victor, Sunita Prem; Sharma, Chandra P

2013-08-01

The objective of this study was to prepare pH sensitive polymethacrylic acid-calcium deficient hydroxyapatite (CDHA) nanocomposites. The CDHA nanoparticles were prepared by coprecipitation method. The modification of CDHA by methacrylic acid (MA) was achieved by AIBN initiated free radical polymerization with sodium bisulphite as catalyst followed by emulsion technique. These nanocomposites with a half life of 8h consisted of high aspect ratio, needle like particles and exhibited an increase in swelling behaviour with pH. The in vivo potential of the nanocomposites was evaluated in vitro by the results of cell aggregation, protein adsorption, MTT assay and haemolytic activity. The invitro loading and release studies using albumin as a model drug indicate that the nanocomposites gave better loading when compared to the CDHA nanoparticles and altered the drug release rates. The nanocomposites also exhibited good uptake on C6 glioma cells as studied by fluorescence microscopy. The results obtained suggest that these nanocomposites have great potential for oral controlled protein delivery and can be extended further for intracellular drug delivery applications. Copyright © 2013 Elsevier B.V. All rights reserved.

Cold Gas in Quenched Dwarf Galaxies using HI-MaNGA

Science.gov (United States)

Bonilla, Alaina

2017-01-01

MaNGA (Mapping of Nearby Galaxies at Apache Point Observatory) is a 6-year Sloan Digital Sky Survey fourth generation (SDSS-IV) project that will obtain integral field spectroscopy of a catalogue of 10,000 nearby galaxies. In this study, we explore the properties of the passive dwarf galaxy sample presented in Penny et al. 2016, making use of MaNGA IFU (Integral Field Unit) data to plot gas emission, stellar velocity, and flux maps. In addition, HI-MaNGA, a legacy radio-survey of MaNGA, collects single dish HI data retrieved from the GBT (Green Bank Telescope), which we use to study the the 21cm emission lines present in HI detections. Studying the HI content of passive dwarves will help us reveal the processes that are preventing star formation, such as possible AGN feedback. This work was supported by the SDSS Research Experience for Undergraduates program, which is funded by a grant from the Sloan Foundation to the Astrophysical Research Consortium.

Ma2 antibodies: an evaluation of commercially available detection methods.

Science.gov (United States)

Johannis, Wibke; Renno, Joerg H; Wielckens, Klaus; Voltz, Raymond

2011-01-01

Ma2 antibodies belong to the onconeuronal antibodies which define a "definite" paraneoplastic neurological syndrome (PNS). Because of the clinical relevance, use of two separate methods (indirect immunofluorescence technique--IFT--and immunoblot) is advocated; however, with an increasing number of commercially available assay systems, usually only one assay is performed. We compared IFT and three commercially available immunoblots (ravo Diagnostika, Euroimmun, Milenia Biotec) on sera from 35 patients with clinically suspected PNS. 17 were Ma2 antibody associated as defined by consensus result (showing positive reactivity in 2 assays), 18 were Ma2 antibody negative controls. Sensitivity/specificity for single assays were for IFT 94%/94%, for ravo Diagnostika PNS blot 88%/100%, for Euroimmun Neuronal Antigens Profile blot 100%/89%, and for Milenia Biotec MTR blot 94%/100%. Our data confirm, although all tests performed well, a combination of 2 independent assays is still advisable for Ma2 antibody detection in order to achieve higher sensitivity and specificity rates.

Patent Analysis for Supporting Merger and Acquisition (M&A) Prediction: A Data Mining Approach

Science.gov (United States)

Wei, Chih-Ping; Jiang, Yu-Syun; Yang, Chin-Sheng

M&A plays an increasingly important role in the contemporary business environment. Companies usually conduct M&A to pursue complementarity from other companies for preserving and/or extending their competitive advantages. For the given bidder company, a critical first step to the success of M&A activities is the appropriate selection of target companies. However, existing studies on M&A prediction incur several limitations, such as the exclusion of technological variables in M&A prediction models and the omission of the profile of the respective bidder company and its compatibility with candidate target companies. In response to these limitations, we propose an M&A prediction technique which not only encompasses technological variables derived from patent analysis as prediction indictors but also takes into account the profiles of both bidder and candidate target companies when building an M&A prediction model. We collect a set of real-world M&A cases to evaluate the proposed technique. The evaluation results are encouraging and will serve as a basis for future studies.

42 CFR 422.52 - Eligibility to elect an MA plan for special needs individuals.

Science.gov (United States)

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Eligibility to elect an MA plan for special needs..., and Enrollment § 422.52 Eligibility to elect an MA plan for special needs individuals. (a) General rule. In order to elect a specialized MA plan for a special needs individual (Special Needs MA plan, or...

La evolución del mejoramiento del maíz

OpenAIRE

Arriaga, Héctor O.

1987-01-01

La producción e importancia primordial del maíz como grano forrajero, hacen que se sindique al maíz como el cereal más representativo de los países desarrollados. Por su producción mundial, ocupa el 2° lugar, después del trigo, con 481 millones de toneladas, de las que el 64 % corresponde a los países desarrollados. Estos son, a su vez, los principales exportadores y consumidores por ser también los más importantes importadores, con un 71 % de las 68 millones de toneladas de maíz que se...

46 CFR 308.529 - Surety Bond B, Form MA-309.

Science.gov (United States)

2010-10-01

... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.529 Surety Bond B, Form MA-309. An Assured who elects to substitute a surety bond for a collateral deposit fund shall submit Form MA-309...

Salatoimikud : ma tahan uskuda / Mart Rummo

Index Scriptorium Estoniae

Rummo, Mart

2008-01-01

USA sarjale "The X-Files" põhinev teine järjefilm "Salatoimikud: Ma tahan uskuda" ("The X-Files: I Want to Believe") : režissöör Chris Carter : peaosades David Duchovny, Gillian Anderson : Ameerika Ühendriigid - Kanada 2008

Colonização micorrízica arbuscular e tolerância ao mal-do-Panamá em mudas de banana-maçã Colonisation of arbuscular mycorrhiza and tolerance to Panama disease in seedlings of the maçã banana

Directory of Open Access Journals (Sweden)

Deusiane Batista Sampaio

2012-09-01

Full Text Available O objetivo desse trabalho foi avaliar o efeito da colonização micorrízica arbuscular na tolerância da bananeira, cv. Maçã, ao mal-do-Panamá, sob diferentes fontes de nutrientes. Utilizou-se um delineamento inteiramente casualizado com fatorial 2 x 4 [2 densidades de esporos de FMA nativos (D1 - 3.500 esporos kg-1 solo e D2 - 7.000 esporos kg-1 solo e 4 diferentes concentrações de fontes de nutrientes - três de solução nutritiva (SN 40%, SN 70% e SN 100% e uma de biofertilizante 100% (B4] com três repetições. Após o plantio inoculou-se Fusarium oxysporum f.sp. cubense e posteriormente avaliou-se matéria seca da parte aérea (MSPA, o teor de fósforo foliar (P, a colonização micorrízica, o pH do solo e o índice de severidade da doença (ID. As diferentes fontes de nutrientes influenciaram a matéria seca da parte aérea, o teor de fósforo, a colonização micorrízica e o índice de severidade da doença, porém não influenciaram o pH da solução do solo. O biofertilizante não atendeu à demanda nutricional das plantas, as quais se mostraram pouco desenvolvidas. Porém proporcionou intensa colonização micorrízica e menor índice de severidade da fusariose, o qual aumentou com a adubação mineral.The aim of this study was to evaluate the effect of the colonization of arbuscular mycorrhiza on the tolerance to Panama disease of the banana plant cv. maçã under different sources of nutrients. A completely randomized design was employed, having a 2 x 4 factorial [2 densities of native FMA spores (D1 - 3,500 spores kg-1 soil and D2 - 7000 spores kg-1 soil and four different concentrations of nutrient sources - three of a nutrient solution (SN 40%, SN 70% and SN 100% and a 100% solution of bio-fertiliser (B4], with three replications. After planting, the seedlings were inoculated with Fusarium oxysporum f.sp. cubense, and later the shoot dry matter, leaf phosphorus content, mycorrhizal colonization, soil pH and disease

MaMiCo: Software design for parallel molecular-continuum flow simulations

KAUST Repository

Neumann, Philipp; Flohr, Hanno; Arora, Rahul; Jarmatz, Piet; Tchipev, Nikola; Bungartz, Hans-Joachim

2015-01-01

The macro-micro-coupling tool (MaMiCo) was developed to ease the development of and modularize molecular-continuum simulations, retaining sequential and parallel performance. We demonstrate the functionality and performance of MaMiCo by coupling

Positive and Negative Impacts of Cross-border M&A

Institute of Scientific and Technical Information of China (English)

裴长洪; 林江

2007-01-01

Mergers and acquisitions of Chinese enterprises by foreign investors have moved onto the public radar in recent years.To date,the M&A frenzy has drawn widespread attention,with a mixed reaction from proponents and opponents.Proponents consider such mergers and acquisitions conducive to realizing strategic readjustment of the national economic structure,optimizing resource allocation and improving the corporate governance structure.Opponents,however,are concerned that foreign mergers and acquisitions may jeopardize China’s industrial security and erode the executive power of the central government in undertaking industrial development planning.Are the benefits of M&A outweighed by the costs,or vice versa? The focus column of this edition features two articles which debate this issue from opposing viewpoints.In the article"Positive and Negative Impacts of Cross-border M&A",the authors consider foreign M(?)A to be a new way of boosting the level of foreign investment utilization,and advocate China taking full advantage of this approach.The authors of the article"Self-Improvement Or Self-Mutilation",meanwhile,hold foreign M&A to blame for state-owned asset erosion,and insist that China should oppose mergers and acquisitions of key state- owned enterprises by foreign investors at fire-sale prices.

[The medical theory of Lee Je-ma and its character].

Science.gov (United States)

Lee, Kyung-Lock

2005-12-01

Lee Je-ma 1837-1900) was a prominent scholar as well as an Korean physician. classified every people into four distinctive types: greater yang [tai yang] person, lesser yin [shao yin] person, greater yin [tai yin] person, lesser yin [shao yin] person. This theory would dictate proper treatment for each type in accordance with individual differences of physical and temperament features. Using these four types he created The Medical Science of Four Types. This article is intended to look into the connection between Lee Je-Ma's 'The Medical Science of Four Types' and 'The Modern' with organizing his ideas about the human body and the human being. Through The Modern, the theory of human being underwent a complete change. Human being in The Premodern, which was determined by sex, age and social status has been changed to the individual human being, which is featured by equality. Lee Je-Ma's medical theory of The Medical Science of Four Types would be analyzed as follow. His concept of human body is oriented toward observable objectivity. But on the other hand, it still remains transcendent status of medical science, which is subordinated by philosophy. According to Lee Je-Ma's theory of human being, human is an equal individual in a modern way of thinking, not as a part of hierarchical group. But on the other hand, it still remains incomplete from getting rid of morality aspect that includes virtue and vice in the concept of human body. The common factors in Lee Je-Ma's ideas about the human body and the human being is 'Dualism of mind and body that means all kinds of status and results depends on each individual. As is stated above, Lee Je-Ma's medical theory has many aspects of The Modern and it proves that Korean traditional medicine could be modernized by itself.

Deleuze, Bergson, Bachelard et Bazin,les ambigüités entre phénoménologie et sémiotique pour une théorie du temps filmique

Directory of Open Access Journals (Sweden)

Lenice Pereira Barbosa

2013-12-01

Full Text Available Ce texte est né de la nécessité de structurer théoriquement ce qui, selon une approche empirique, est une évidence : aborder les considérations d’André Bazin et de Gilles Deleuze concernant le temps cinématographique à travers un point de vue phénoménologique. Ceci pourrait, bien évidemment, entrainer un « chassé-croisé » théorique entre Sémiotique et Phénoménologie qui se neutraliseraient les unes les autres sans apporter de changements par rapport à la perception chromatique du temps. L’objectif principal de ce travail est d’élargir le sens attribué à l’élément couleur au cinéma et de mettre en exergue le rapport entre les manifestations chromatiques et la perception du temps. À partir de ces points, il est également possible de considérer le principe multi – disciplinaire que ces éléments nous imposent, inspiré par l’évidence de la continuité-discontinuité qui, en tout cas au cinéma, n’est pas nécessairement un dilemme. Ainsi, il s’agit de faire coexister dans une approche phénoménologique certaines conceptions de Bergson et de Bachelard concernant la perception du temps.

Development of Hybrid pH sensor for long-term seawater pH monitoring.

Science.gov (United States)

Nakano, Y.; Egashira, T.; Miwa, T.; Kimoto, H.

2016-02-01

We have been developing the in situ pH sensor (Hybrid pH sensor: HpHS) for the long-term seawater pH monitoring. We are planning to provide the HpHS for researchers and environmental consultants for observation of the CCS (Carbon dioxide Capture and Storage) monitoring system, the coastal environment monitoring system (e.g. Blue Carbon) and ocean acidification. The HpHS has two types of pH sensors (i.e. potentiometric pH sensor and spectrophotometric pH sensor). The spectrophotometric pH sensor can measure pH correctly and stably, however it needs large power consumption and a lot of reagents in a long period of observation. The pH sensor used m-cresol purple (mCP) as an indicator of pH (Clayton and Byrne, 1993 and Liu et al., 2011). We can choose both coefficients before deployment. On the other hand, although the potentiometric pH sensor is low power consumption and high-speed response (within 10 seconds), drifts in the pH of the potentiometric measurements may possibly occur for a long-term observation. The HpHS can measure in situ pH correctly and stably combining advantage of both pH sensors. The HpHS consists of an aluminum pressure housing with optical cell (main unit) and an aluminum silicon-oil filled, pressure-compensated vessel containing pumps and valves (diaphragm pump and valve unit) and pressure-compensated reagents bags (pH indicator, pure water and Tris buffer or certified reference material: CRM) with an ability to resist water pressure to 3000m depth. The main unit holds system control boards, pump drivers, data storage (micro SD card), LED right source, photodiode, optical cell and pressure proof windows. The HpHS also has an aluminum pressure housing that holds a rechargeable lithium-ion battery or a lithium battery for the power supply (DC 24 V). The HpHS is correcting the value of the potentiometric pH sensor (measuring frequently) by the value of the spectrophotometric pH sensor (measuring less frequently). It is possible to calibrate in

MaNGA: Mapping Nearby Galaxies at Apache Point Observatory

Science.gov (United States)

Weijmans, A.-M.; MaNGA Team

2016-10-01

MaNGA (Mapping Nearby Galaxies at APO) is a galaxy integral-field spectroscopic survey within the fourth generation Sloan Digital Sky Survey (SDSS-IV). It will be mapping the composition and kinematics of gas and stars in 10,000 nearby galaxies, using 17 differently sized fiber bundles. MaNGA's goal is to provide new insights in galaxy formation and evolution, and to deliver a local benchmark for current and future high-redshift studies.

Technical committee on reactor physics of next generation. Examination of MA recycling by using PWRs

International Nuclear Information System (INIS)

Mori, Masaaki

1995-01-01

It is an important subject to be examined that during the period till full scale nuclear fuel recycling including the adoption of FBRs will be realized, we never have excess Pu. As the realistic examination considering the nuclear fuel recycling for the time being, the MOX fuel for PWRs of actinide recycling, ultralong life, placing emphasis on the concentrated charging of Pu and the confinement of MA in nuclear fuel cycling was examined. The change of the infinite multiplication rate of actinide recycling fuel is small throughout the burning, and there is the possibility of attaining the high burnup about twice of that of UO 2 fuel. The merit of the case of adding MA in small amount by recycling MA together with Pu at the proportion in spent fuel is shown. The amount of MA accumulation in Japan until 2050 was evaluated by the survey of the electric power generation of every reactor type using the long term reactor type strategy evaluation code LSER. By comparing the amount of MA accumulation in four MA recycling cases with the basic case without MA recycling, the amount of MA annihilation was evaluated. It was found that the MA recycling using PWRs only is not inferior to the multi-recycling of MA using FBRs. (K.I.)

How to use MAED with other IAEA models in ENPEP

International Nuclear Information System (INIS)

Maksijan, B.

1997-01-01

This paper provides an outlook of the energy situation in Croatia and describes the experience with the IAEA planning methodologies with focus on the MAED model. Furthermore, it suggests an approach to integrate the results of the MAED module of ENPEP with other modules (e.g. BALANCE) by means of commercial software (EXCEL Microsoft). (author). 2 figs, 3 tabs

How to use MAED with other IAEA models in ENPEP

Energy Technology Data Exchange (ETDEWEB)

Maksijan, B [Energy Sector, Ministry of Economic Affairs, Zagreb (Croatia)

1997-09-01

This paper provides an outlook of the energy situation in Croatia and describes the experience with the IAEA planning methodologies with focus on the MAED model. Furthermore, it suggests an approach to integrate the results of the MAED module of ENPEP with other modules (e.g. BALANCE) by means of commercial software (EXCEL Microsoft). (author). 2 figs, 3 tabs.

Pfister y la Hibridación del Maíz

Directory of Open Access Journals (Sweden)

Kent. George

1940-03-01

Full Text Available En la Facultad Nacional de Agronomía, se están haciendo actualmente los trabajos de aclimatación del "maíz hibrido Pfister". Cuando el suscrito tuvo conocimiento del "maíz híbrido" obtenido como fruto de una experimentación de más de 20 años llevada a cabo en Illinois por el señor Pfister, se interesó vivamente en traer unas semillas a Colombia para intentar el proceso de aclimatación de las mejores variedades. A pesar de una larga correspondencia con el señor Pfister desde hace dos años, no nos fue posible lograr nuestro objeto. Durante la última visita del suscrito a ese país, obtuve, como una merced personal, una muy pequeña cantidad de las ocho mejores variedades de maíz híbrido, y al efecto, a la presente le estoy incluyendo a usted esas semillas de maíz sin otra retribución para nosotros, que el de hacer las siembras, observaciones y experimentaciones con todo el cuidado de que usted es capaz, y darnos cuenta oportuna de los resultados obtenidos con cada una de las variedades. Cada talego está marcado con el número de la variedad y no está por demás rogar a usted de la manera más encarecida llevar a efecto este trabajo con el mayor cuidado e interés para corresponder por lo menos al que hemos tenido nosotros en proporcionarle las dichas semillas. A pesar de que en Estados Unidos han hecho una súper selección de maíz en los últimos 50 años, las semillas seleccionadas han; quedado superadas por el maíz "Híbrido Pfister" con rendimientos de más de un 60%. Como nosotros no hemos hecho nada en selección de maíz, nuestro trabajo se puede limitar a un proceso de "aclimatación", que si logramos, tendríamos ganados muchos años de trabajo.

MaGnET: Malaria Genome Exploration Tool.

Science.gov (United States)

Sharman, Joanna L; Gerloff, Dietlind L

2013-09-15

The Malaria Genome Exploration Tool (MaGnET) is a software tool enabling intuitive 'exploration-style' visualization of functional genomics data relating to the malaria parasite, Plasmodium falciparum. MaGnET provides innovative integrated graphic displays for different datasets, including genomic location of genes, mRNA expression data, protein-protein interactions and more. Any selection of genes to explore made by the user is easily carried over between the different viewers for different datasets, and can be changed interactively at any point (without returning to a search). Free online use (Java Web Start) or download (Java application archive and MySQL database; requires local MySQL installation) at http://malariagenomeexplorer.org joanna.sharman@ed.ac.uk or dgerloff@ffame.org Supplementary data are available at Bioinformatics online.

Anti-ma2 paraneoplastic encephalitis in association with recurrent cervical cancer.

Science.gov (United States)

Ney, Douglas E; Messersmith, Wells; Behbakht, Kian

2014-07-01

Paraneoplastic neurological syndromes are rare, and although they are frequently associated with gynecological malignancies, cervical cancer is a rare cause. The symptoms of anti-Ma2 encephalitis are diverse and often present prior to the diagnosis of malignancy. We report a case of a 37-year-old woman with a history of cervical cancer presenting with unexplained weight gain and vertical supranuclear gaze palsy. Magnetic resonance imaging of the brain revealed lesions within the bilateral hypothalami and midbrain. Anti-Ma2 antibodies were eventually found in the serum, prompting a search for malignancy. Recurrent metastatic cervical cancer was found in the retroperitoneal lymph nodes. This is the first report of cervical cancer in association with anti-Ma2 encephalitis, and highlights the need for a high degree of suspicion in patients with a cancer history presenting with neurological symptoms. The symptoms associated with anti-Ma2 encephalitis are diverse and typically precede the diagnosis of cancer in patients, and should trigger a search for an underlying malignancy.

Mapping Nearby Galaxies at APO: The MaNGA IFU Galaxy Survey

Science.gov (United States)

Law, David R.; MaNGA Team

2014-01-01

MaNGA is a new survey that will begin in August 2014 as part of SDSS-IV with the aim of obtaining integral-field spectroscopy for an unprecedented sample of 10,000 nearby galaxies. MaNGA's key goals are to understand the "life cycle" of present day galaxies from imprinted clues of their birth and assembly, through their ongoing growth via star formation and merging, to their death from quenching at late times. To achieve these goals, MaNGA will channel the impressive capabilities of the SDSS-III BOSS spectrographs in a fundamentally new direction by marshaling the unique power of 2D spectroscopy. MaNGA will deploy 17 pluggable Integral Field Units (IFUs) made by grouping fibers into hexagonal bundles ranging from 19 to 127 fibers each. The spectra obtained by MaNGA will cover the wavelength range 3600-10,000 Angstroms (with a velocity resolution of ~ 60 km/s) and will characterize the internal composition and the dynamical state of a sample of 10,000 galaxies with stellar masses greater than 10^9 Msun and an average redshift of z ~ 0.03. Such IFU observations enable a leap forward because they provide an added dimension to the information available for each galaxy. MaNGA will provide two-dimensional maps of stellar velocity and velocity dispersion, mean stellar age and star formation history, stellar metallicity, element abundance ratio, stellar mass surface density, ionized gas velocity, ionized gas metallicity, star formation rate, and dust extinction for a statistically powerful sample. This legacy dataset will address urgent questions in our understanding of galaxy formation, including 1) The formation history of galaxy subcomponents, including the disk, bulge, and dark matter halo, 2) The nature of present-day galaxy growth via merging and gas accretion, and 3) The processes responsible for terminating star formation in galaxies. Finally, MaNGA will also play a vital role in the coming era of advanced IFU instrumentation, serving as the low-z anchor for

Spontaneous atopic dermatitis-like symptoms in a/a ma ft/ma ft/J flaky tail mice appear early after birth.

Directory of Open Access Journals (Sweden)

Magdalini Kypriotou

Full Text Available Loss-of-function mutations in human profilaggrin gene have been identified as the cause of ichthyosis vulgaris (IV, and as a major predisposition factor for atopic dermatitis (AD. Similarly, flaky tail (a/a ma ft/ma ft/J mice were described as a model for IV, and shown to be predisposed to eczema. The aim of this study was to correlate the flaky tail mouse phenotype with human IV and AD, in order to dissect early molecular events leading to atopic dermatitis in mice and men, suffering from filaggrin deficiency. Thus, 5-days old flaky tail pups were analyzed histologically, expression of cytokines was measured in skin and signaling pathways were investigated by protein analysis. Human biopsies of IV and AD patients were analyzed histologically and by real time PCR assays. Our data show acanthosis and hyperproliferation in flaky tail epidermis, associated with increased IL1β and thymic stromal lymphopoietin (TSLP expression, and Th2-polarization. Consequently, NFκB and Stat pathways were activated, and IL6 mRNA levels were increased. Further, quantitative analysis of late epidermal differentiation markers revealed increased Small proline-rich protein 2A (Sprr2a synthesis. Th2-polarization and Sprr2a increase may result from high TSLP expression, as shown after analysis of 5-days old K14-TSLP tg mouse skin biopsies. Our findings in the flaky tail mouse correlate with data obtained from patient biopsies of AD, but not IV. We propose that proinflammatory cytokines are responsible for acanthosis in flaky tail epidermis, and together with the Th2-derived cytokines lead to morphological changes. Accordingly, the a/a ma ft/ma ft/J mouse model can be used as an appropriate model to study early AD onset associated with profilaggrin deficiency.

INFLUÊNCIA DE DIFERENTES pH DO MEIO DE AQUECIMENTO NA RESISTÊNCIA TÉRMICA DE Neosartorya fischeri ISOLADO DO PROCESSO PRODUTIVO DE NÉCTAR DE MAÇÃ INFLUENCE OF DISTINCT PH VALUES IN THE THERMAL RESISTANCE OF NEOSARTORYA FISCHERI ISOLATED FROM APPLE NECTAR PROCESSING

Directory of Open Access Journals (Sweden)

B. C. M. SALOMÃ?O

2008-08-01

Full Text Available

A resistência térmica de ascósporos de N. fischeri, isolados do concentrado de maçã, foi verificada utilizando-se tubos TDT (Thermal Death Time selados, e suco de maçã, a diferentes pHs, como meio de aquecimento. As curvas obtidas a 80, 85 e 90°C mostraram um “ombro” inicial evidenciando comportamento de morte não logarítmica. Assim, o cálculo dos parâmetros cinéticos foi realizado através da linearização das mesmas. Os valores de “1/k” obtidos em pH 2,5 foram 81,3; 16,0 e 0,9 minutos para 80, 85 e 90°C, respectivamente; em pH 3,5 foram de 153,8; 22,0 e 1,0 minutos e em pH 4,5 foram de 312,5; 38,6 e 2,2 minutos, para as mesmas respectivas temperaturas. O valor de Z* (equivalente a Z foi 5,0°C a pH 2,5 e o mesmo valor (4,6°C foi encontrado em pH 3,5 e 4,5. Os valores de esterilização F_(95°C nos pHs 2,5; 3,5 e 4,5 foram respectivamente 44,6; 36,8, e 77,0 segundos, considerando-se a redução da população inicial em 6 ciclos logarítmicos. Como o tratamento térmico comercial normalmente aplicado ao suco de maçã é de 95°C/30s, pode-se concluir que este não será suficientemente seguro para atingir a probabilidade de sobrevivência de 1 ascósporo a cada 10⁵ embalagens, o que seria esperado.

Evaluation overview for the Massachusetts Childhood Obesity Research Demonstration (MA-CORD) project.

Science.gov (United States)

Davison, Kirsten K; Falbe, Jennifer; Taveras, Elsie M; Gortmaker, Steve; Kulldorff, Martin; Perkins, Meghan; Blaine, Rachel E; Franckle, Rebecca L; Ganter, Claudia; Baidal, Jennifer Woo; Kwass, Jo-Ann; Buszkiewicz, James; Smith, Lauren; Land, Thomas

2015-02-01

The Massachusetts Childhood Obesity Research Demonstration (MA-CORD) project is a 2-year, multilevel, multisector community intervention to prevent and control obesity among children 2-12 years of age from two predominantly low-income communities in Massachusetts. MA-CORD includes evidence-based interventions in multiple sectors, including community health centers, early care and education centers, schools, afterschool programs, the Special Supplemental Nutrition Program for Women, Infants and Children, and the broader community. Currently, implementation of MA-CORD is complete and the final year of data collection is in progress. Here, the MA-CORD evaluation plan is described and baseline data are presented. The impact of MA-CORD on children's BMI, lifestyle behaviors, obesity-related care, and quality of life will be assessed using sector-specific, pre/post, time-series, and quasi-experimental designs. Change in the primary outcomes will be compared for intervention and comparison communities. Additionally, change in mean BMI and obesity prevalence in intervention school districts will be compared to similar districts throughout the state. At baseline in 2012, approximately 16% of preschool-aged and 25% of school-aged children were obese. Moreover, 15-40% of children consumed no vegetables on the previous day, 25-75% drank a sugar-sweetened beverage on the previous day, up to 87% had insufficient physical activity, 50-75% had a television in the room where they slept, and 50-80% obtained insufficient sleep. There is ample room for improvement in BMI and health behaviors in children in MA-CORD communities. If successful, MA-CORD may serve as a model for multilevel, multisector approaches to childhood obesity prevention and control.

Development of ITER 15 MA ELMy H-mode Inductive Scenario

International Nuclear Information System (INIS)

C. E. Kessel, D. Campbell, Y. Gribov, G. Saibene, G. Ambrosino, T. Casper, M. Cavinato, H. Fujieda, R. Hawryluk, L. D. Horton, A. Kavin, R. Kharyrutdinov, F. Koechl, J. Leuer, A. Loarte, P. J. Lomas, T. Luce, V. Lukash, M. Mattei, I.Nunes, V. Parail, A. Polevoi, A. Portone, R. Sartori, A.C.C. Sips, P. R. Thomas, A. Welander and J. Wesley

2008-01-01

The poloidal field (PF) coil system on ITER, which provides both feedforward and feedback control of plasma position, shape, and current, is a critical element for achieving mission performance. Analysis of PF capabilities has focused on the 15 MA Q = 10 scenario with a 300-500 s flattop burn phase. The operating space available for the 15 MA ELMy H-mode plasma discharges in ITER and upgrades to the PF coils or associated systems to establish confidence that ITER mission objectives can be reached have been identified. Time dependent self-consistent free-boundary calculations were performed to examine the impact of plasma variability, discharge programming, and plasma disturbances. Based on these calculations a new reference scenario was developed based upon a large bore initial plasma, early divertor transition, low level heating in L-mode, and a late H-mode onset. Equilibrium analyses for this scenario indicate that the original PF coil limitations do not allow low li (<0.8) operation or lower flux states, and the flattop burn durations were predicted to be less than the desired 400 s. This finding motivates the expansion of the operating space, considering several upgrade options to the PF coils. Analysis was also carried out to examine the feedback current reserve required in the CS and PF coils during a series of disturbances and a feasibility assessment of the 17 MA scenario was undertaken. Results of the studies show that the new scenario and modified PF system will allow a wide range of 15 MA 300-500 s operation and more limited but finite 17 MA operation

Adsorção de cromo (VI por carvão ativado granular de soluções diluídas utilizando um sistema batelada sob pH controlado Chromium (VI adsorption by GAC from diluted solutions in batch system and controlled ph

Directory of Open Access Journals (Sweden)

Renata Santos Souza

2009-09-01

Full Text Available Na Amazônia o cromo é empregado principalmente na indústria de couro e de madeira, sendo responsável por vários problemas de saúde porque é tóxico para os seres vivos. A remoção de cromo de efluentes industriais é feita por meio de diversos processos como a adsorção. Este trabalho mostra os resultados da adsorção de Cr(VI por carvão ativado granular comercial (CAG como adsorvente de soluções diluídas empregando um sistema de adsorção batelada com controle de pH. Os grupos funcionais da superfície do CAG foram determinados pelo método de Boehm. Além disso, o efeito do pH na adsorção de Cr(VI, o equilíbrio e a cinética de adsorção foram estudados nas condições experimentais (pH = 6, MA = 6g, tempo de adsorção 90min.. Na superfície do CAG, os grupos carboxílicos foram determinados em maior concentração (MAS=0,43 mmol/gCAG, estes, presentes em concentrações elevadas aumentam a adsorção do metal, principalmente em valores de pH ácidos. A capacidade de adsorção é dependente do pH da solução, devido a sua influência nas propriedades de superfície do CAG e nas diferentes formas iônicas das soluções de Cr(VI. Os dados de equilíbrio da adsorção foram ajustados satisfatoriamente pela isoterma de Langmuir (R²=0,988, tipo favorável. A partir da cinética de adsorção a 5mg/L e 20mg/L, os resultados obtidos foram compatíveis com o valor limite preconizado na legislação nacional (Res. nº 357/05. Portanto, para o sistema experimental utilizando CAG foi eficiente na remoção de Cr(VI a partir de correntes líquidas contendo baixas concentrações do metal.In Amazonia, chromium is mainly used in the leather and wood industries. It is responsible for many health problems, because of its toxicity. These industries remove chromium waste by various processes, such as adsorption. This work shows the results of Cr(VI adsorption by commercial granular activated carbon (GAC as adsorbent from diluted

The medical theory of Lee Je-ma and its character

Directory of Open Access Journals (Sweden)

LEE Kyung-Lock

2005-12-01

Full Text Available Lee Je-ma(李濟馬, 1837-1900 was a prominent scholar as well as an Korean physician He classified every people into four distinctive types: greater yang[tai yang] person, lesser yin[shao yin] person greater yin[tai yin] person, lesser yin[shao yin] person. This theory would dictate proper treatment for each type in accordance with individual differences of physical and temperament features Using these four types he created The Medical Science of Four Types(四象體質論.This article is intended to look into the connection between Lee Je-Ma's 'The Medical Science of Four Types' and 'The Modern' with organizing his ideas about the human body and the human being. Through The Modern, the theory of human being(人間觀 underwent a complete change. Human being in The Premodern, which was determined by sex, age and social status has been changed to the individual human being, which is featured by equality. Lee Je-Ma's medical theory of The Medical Science of Four Types would be analyzed as follow. His concept of human body(人體論 is oriented toward observable objectivity. But on the other hand, it still remains transcendent status of medical science, which is subordinated by philosophy According to Lee Je-Ma's theory of human being human is an equal individual in a modern way of thinking not as a part of hierarchical group. But on the other hand, it still remains incomplete from getting rid of morality aspect that includes virtue and vice in the concept of human body.The common factors in Lee Je-Ma's ideas about the human body and the human being is 'Dualism of mind and body(心身二元論' that means all kinds of status and results depends on each individual. As is stated above, Lee Je-Ma's medical theory has many aspects of The Modern and it proves that Korean traditional medicine could be modernized by itself.

Design of an upgradeable 45-100 mA RFQ accelerator for FAIR

Science.gov (United States)

Zhang, Chuan; Schempp, Alwin

2009-10-01

A 325 MHz, 35 mA, 3 MeV Radio-Frequency Quadrupole (RFQ) accelerator will be operated as the first accelerating structure of the proton linac injector for the newly planned international science center Facility for Antiproton and Ion Research (FAIR) at GSI, Germany. In previous design studies, two high beam intensities, 70 and 100 mA, were used. Most recently, the design intensity has been changed to 45 mA, which is closer to the operational value. Taking advantage of the so-called New Four-Section Procedure, a new design, which is upgradable from 45 to 100 mA, has been developed for the FAIR proton RFQ. Besides the upgradability analyses, robustness studies of the new design to spatial displacements of the input beam and field errors are presented as well.

Design of an upgradeable 45-100 mA RFQ accelerator for FAIR

International Nuclear Information System (INIS)

Zhang Chuan; Schempp, Alwin

2009-01-01

A 325 MHz, 35 mA, 3 MeV Radio-Frequency Quadrupole (RFQ) accelerator will be operated as the first accelerating structure of the proton linac injector for the newly planned international science center Facility for Antiproton and Ion Research (FAIR) at GSI, Germany. In previous design studies, two high beam intensities, 70 and 100 mA, were used. Most recently, the design intensity has been changed to 45 mA, which is closer to the operational value. Taking advantage of the so-called New Four-Section Procedure, a new design, which is upgradable from 45 to 100 mA, has been developed for the FAIR proton RFQ. Besides the upgradability analyses, robustness studies of the new design to spatial displacements of the input beam and field errors are presented as well.

Recurrent Early Cretaceous, Indo-Madagascar (89-86 Ma) and Deccan (66 Ma) alkaline magmatism in the Sarnu-Dandali complex, Rajasthan: 40Ar/39Ar age evidence and geodynamic significance

Science.gov (United States)

Sheth, Hetu; Pande, Kanchan; Vijayan, Anjali; Sharma, Kamal Kant; Cucciniello, Ciro

2017-07-01

The Sarnu-Dandali alkaline complex in Rajasthan, northwestern India, is considered to represent early, pre-flood basalt magmatism in the Deccan Traps province, based on a single 40Ar/39Ar age of 68.57 Ma. Rhyolites found in the complex are considered to be 750 Ma Malani basement. Our new 40Ar/39Ar ages of 88.9-86.8 Ma (for syenites, nephelinite, phonolite and rhyolite) and 66.3 ± 0.4 Ma (2σ, melanephelinite) provide clear evidence that whereas the complex has Deccan-age (66 Ma) components, it is dominantly an older (by 20 million years) alkaline complex, with rhyolites included. Basalt is also known to underlie the Early Cretaceous Sarnu Sandstone. Sarnu-Dandali is thus a periodically rejuvenated alkaline igneous centre, active twice in the Late Cretaceous and also earlier. Many such centres with recurrent continental alkaline magmatism (sometimes over hundreds of millions of years) are known worldwide. The 88.9-86.8 Ma 40Ar/39Ar ages for Sarnu-Dandali rocks fully overlap with those for the Indo-Madagascar flood basalt province formed during continental breakup between India (plus Seychelles) and Madagascar. Recent 40Ar/39Ar work on the Mundwara alkaline complex in Rajasthan, 120 km southeast of Sarnu-Dandali, has also shown polychronous emplacement (over ≥ 45 million years), and 84-80 Ma ages obtained from Mundwara also arguably represent post-breakup stages of the Indo-Madagascar flood basalt volcanism. Remnants of the Indo-Madagascar province are known from several localities in southern India but hitherto unknown from northwestern India 2000 km away. Additional equivalents buried under the vast Deccan Traps are highly likely.

PH sensor

OpenAIRE

Artero, C.; Nogueras Cervera, Marc; Manuel Lázaro, Antonio

2012-01-01

This paper presents a design of a marine instrument for the measurement of pH in seawater. The measurement system consists of a pH electrode connected to the underwater observatory OBSEA. The extracted data are useful for scientists researching ocean acidification. Peer Reviewed

Evaluation of biodegradation of bionanocomposites of PHB/PP-g-MA/vermiculite; Avaliacao da biodegradacao de bionanocompositos de PHB/PP-g-MA/vermiculita

Energy Technology Data Exchange (ETDEWEB)

Mesquita, P.J.P. de; Alves, T.S.; Barbosa, R., E-mail: tsaeng3@yahoo.com.br [Universidade Federal do Piaui (UFPI), Teresina, PI (Brazil). Programa de Pos-Graduacao em Ciencia dos Materiais; Andrade, D. de L.A.C.S. [Universidade Federal de Campina Grande (UFCG), PB (Brazil). Programa de Pos- Graduacao em Ciencia e Engenharia de Materiais

2014-07-01

In this work, we evaluated the process of biodegradation of PHB bionanocomposites/PP-g-MA/clay. Films were prepared with compositions of 5% PP-g-MA and 3% clay (BIO5); and 2.5% PP-g-MA and 3% clay (BIO2.5). The biodegradation test was conducted according to ASTM G 160-03 for a period of 86 days. The evaluation of biodegradation was performed by optical microscopy (MO), loss of mass, FTIR and XRD. The bionanocomposites presented change of coloration and appearance of fissures. As for loss in mass in the system presented loss of BIO2,5 22.5% and 25.9% BIO5, for 86 days of simulated soil exposure. We also observed by FTIR sharp reduction in intensity of the band corresponding to the C = O groups, indicating that the microbial attack promoted cleavage of the ester group links. By XRD, reduction in the intensity of the peaks and enlargements of the same with increasing exposure time, proving the biodegradation behavior of bionanocomposites. (author)

The Response of Eastern African Terrestrial Environments to the Mid-Pleistocene Climate Transition: Paleosol Isotopic Evidence from the Turkana Basin, Kenya

Science.gov (United States)

Quinn, R.; Lepre, C. J.

2017-12-01

Heightened aridity and C4 grass expansion are recorded in Africa during the Mid-Pleistocene Climate Transition (MPCT, 1.3-0.7 Ma), potentially as consequences of decreasing atmospheric CO2. Whether all of Africa responded to the MPCT in the same manner is unclear. Recent studies of a Malawi Basin lake core and paleosols show abundant C3 flora across the MPCT. African climate change is often suggested as a primary cause of hominin speciation, extinction, and technological innovations. Competing environmental-based evolutionary hypotheses propose increased aridity, humidity pulses, and climatic variability as influences of water availability and vegetation structure in Plio-Pleistocene hominin habitats. The Turkana Basin in northern Kenya preserves a rich fossil record of hominins from 4.3-0.7 Ma and offers high-resolution age control via paleomagnetic stratigraphy, isotopic geochronology, and tephrostratigraphy. Turkana's large paleosol isotopic database demonstrates a gradual increase in C4 grass abundance and aridity from 4-1 Ma. Faunal evidence for increasing abundances of C4 grazers corroborates the spread of C4 grasslands from 2-1 Ma. However, there is a dearth of terrestrial environmental records after 1.5 Ma and through the MPCT at Turkana, during which time eastern Africa witnessed the extinction of Paranthropus and the disperal of genus Homo. Here we report a stable isotopic (δ13C, δ18O) record of paleosol carbonates from the Turkana Basin from 1.4 to 0.7 Ma. Based on our findings and comparisons with comparable datasets from other hominin locales, we suggest that eastern African environments responded to the MPCT in a phased shift from south to north, possibly as a consequence of the compression of the ITCZ during glacial maxima and/or to changes to the Indian Ocean Dipole.

Računalniška izdelava ocenjevalne razdelitve na mednarodnih razstavah mačk

OpenAIRE

LAMPER, DEAN

2018-01-01

Na mednarodni razstavi mačk je potrebno prijavljene mačke razdeliti med sodnike, da jih ocenijo. Pri pripravi te razdelitve je potrebno upoštevati mnogo kriterijev, prijavljenih mačk pa je lahko nekaj sto. Zahtevnost priprave dobre razdelitve tako presega človeške zmožnosti, zato smo želeli razdelitev mačk med sodnike optimizirati z metodami umetne inteligence. V nalogi je predstavljeno nekaj algoritmov, ki jih je mogoče uporabiti za izdelavo ocenjevalne razdelitve na mednarodni razstavi m...

« ImpersoNations » : cinéma national, imaginaires historiques et nouveau cinéma européen

OpenAIRE

Elsaesser, Thomas

2014-01-01

La question du capital culturel propre à la diversité linguistique de l’Europe reste entière. Quels sont les avantages et les inconvénients de cet éventail de langues dans le cinéma ? Les films, quand ils franchissent les frontières, sont souvent doublés. Or, comme un bon jeu d’acteur représente une symbiose très particulière entre le corps, la gestuelle, la voix et l’intonation, les amateurs de cinéma ne peuvent se passer des films tournés dans leur propre langue. A l’instar du son, qui revê...

Paraneoplastic brain stem encephalitis in a woman with anti-Ma2 antibody.

Science.gov (United States)

Barnett, M; Prosser, J; Sutton, I; Halmagyi, G M; Davies, L; Harper, C; Dalmau, J

2001-02-01

A woman developed brain stem encephalopathy in association with serum anti-Ma2 antibodies and left upper lobe lung mass. T2 weighted MRI of the brain showed abnormalities involving the pons, left middle and superior cerebellar peduncles, and bilateral basal ganglia. Immunohistochemical analysis for serum antineuronal antibodies was confounded by the presence of a non-neuronal specific antinuclear antibody. Immunoblot studies showed the presence of anti-Ma2 antibodies. A premortem tissue diagnosis of the lung mass could not be established despite two CT guided needle biopsies, and the patient died as a result of rapid neurological deterioration. The necropsy showed that the lung lesion was an adenocarcinoma which expressed Ma2 immunoreactive protein. Neuropathological findings included prominent perivascular inflammatory infiltrates, glial nodules, and neuronophagia involving the brain stem, basal ganglia, hippocampus and the dentate nucleus of the cerebellum. Ma2 is an autoantigen previously identified in patients with germ cell tumours of the testis and paraneoplastic brain stem and limbic encephalitis. Our patient's clinical and immunopathological findings indicate that this disorder can affect women with lung adenocarcinoma, and that the encephalitic changes predominate in those regions of the brain known to express high concentrations of Ma proteins.

, TOUCHE PAS À MA TERRE, I ! ' C'EST MA VIE !

International Development Research Centre (IDRC) Digital Library (Canada)

nouvelles lois afin d'assurer un plus grand contrôle sur leurs terres arables. C'est ... phénomène, du respect des réglementations locales de gestion foncière. ...... imposé dans la mesure où, l'Etat ayant octroyé les différents permis à. Newcrest ...

Comparison of TCeMA and TDMA for Inter-Satellite Communications using OPNET Simulation

Science.gov (United States)

Hain, Regina Rosales; Ramanathan, Ram; Bergamo, Marcos; Wallett, Thomas M.

2003-01-01

A robust data link protocol, enabling unique physical and MAC layer technologies and sub-network level protocols, is needed in order to take advantage of the full potential of using both TDMA and CDMA in a satellite communication network. A novel MAC layer protocol, TDMA with CDMA-encoding multiple access (TCeMA) integrated with null-steered digital beam-forming spatial multiplexing, is investigated to support flexible spacecraft communications. Abstract models of the TCeMA and TDMA processes are developed in OPNFiT and a comparison of the performances of TCeMA and TDMA in a satellite network simulation are made. TCeMA provides the better connectivity and capacity with respect to TDMA for satellite communication traffic.

Predicting Sediment Thickness on Vanished Ocean Crust Since 200 Ma

Science.gov (United States)

Dutkiewicz, A.; Müller, R. D.; Wang, X.; O'Callaghan, S.; Cannon, J.; Wright, N. M.

2017-12-01

Tracing sedimentation through time on existing and vanished seafloor is imperative for constraining long-term eustasy and for calculating volumes of subducted deep-sea sediments that contribute to global geochemical cycles. We present regression algorithms that incorporate the age of the ocean crust and the mean distance to the nearest passive margin to predict sediment thicknesses and long-term decompacted sedimentation rates since 200 Ma. The mean sediment thickness decreases from ˜220 m at 200 Ma to a minimum of ˜140 m at 130 Ma, reflecting the replacement of old Panthalassic ocean floor with young sediment-poor mid-ocean ridges, followed by an increase to ˜365 m at present-day. This increase reflects the accumulation of sediments on ageing abyssal plains proximal to passive margins, coupled with a decrease in the mean distance of any parcel of ocean crust to the nearest passive margin by over 700 km, and a doubling of the total passive margin length at present-day. Mean long-term sedimentation rates increase from ˜0.5 cm/ky at 160 Ma to over 0.8 cm/ky today, caused by enhanced terrigenous sediment influx along lengthened passive margins, superimposed by the onset of ocean-wide carbonate sedimentation. Our predictive algorithms, coupled to a plate tectonic model, provide a framework for constraining the seafloor sediment-driven eustatic sea-level component, which has grown from ˜80 to 210 m since 120 Ma. This implies a long-term sea-level rise component of 130 m, partly counteracting the contemporaneous increase in ocean basin depth due to progressive crustal ageing.

Ma_MISS on ExoMars: Mineralogical Characterization of the Martian Subsurface

Science.gov (United States)

De Sanctis, Maria Cristina; Altieri, Francesca; Ammannito, Eleonora; Biondi, David; De Angelis, Simone; Meini, Marco; Mondello, Giuseppe; Novi, Samuele; Paolinetti, Riccardo; Soldani, Massimo; Mugnuolo, Raffaele; Pirrotta, Simone; Vago, Jorge L.; Ma_MISS Team

2017-07-01

The Ma_MISS (Mars Multispectral Imager for Subsurface Studies) experiment is the visible and near infrared (VNIR) miniaturized spectrometer hosted by the drill system of the ExoMars 2020 rover. Ma_MISS will perform IR spectral reflectance investigations in the 0.4-2.2 μm range to characterize the mineralogy of excavated borehole walls at different depths (between 0 and 2 m). The spectral sampling is about 20 nm, whereas the spatial resolution over the target is 120 μm. Making use of the drill's movement, the instrument slit can scan a ring and build up hyperspectral images of a borehole. The main goal of the Ma_MISS instrument is to study the martian subsurface environment. Access to the martian subsurface is crucial to our ability to constrain the nature, timing, and duration of alteration and sedimentation processes on Mars, as well as habitability conditions. Subsurface deposits likely host and preserve H2O ice and hydrated materials that will contribute to our understanding of the H2O geochemical environment (both in the liquid and in the solid state) at the ExoMars 2020 landing site. The Ma_MISS spectral range and sampling capabilities have been carefully selected to allow the study of minerals and ices in situ before the collection of samples. Ma_MISS will be implemented to accomplish the following scientific objectives: (1) determine the composition of subsurface materials, (2) map the distribution of subsurface H2O and volatiles, (3) characterize important optical and physical properties of materials (e.g., grain size), and (4) produce a stratigraphic column that will inform with regard to subsurface geological processes. The Ma_MISS findings will help to refine essential criteria that will aid in our selection of the most interesting subsurface formations from which to collect samples.

MHD PbLi experiments in MaPLE loop at UCLA

International Nuclear Information System (INIS)

Courtessole, C.; Smolentsev, S.; Sketchley, T.; Abdou, M.

2016-01-01

Highlights: • The paper overviews the MaPLE facility at UCLA: one-of-a-few PbLi MHD loop in the world. • We present the progress achieved in development and testing of high-temperature PbLi flow diagnostics. • The most important MHD experiments carried out since the first loop operation in 2011 are summarized. - Abstract: Experiments on magnetohydrodynamic (MHD) flows are critical to understanding complex flow phenomena in ducts of liquid metal blankets, in particular those that utilize eutectic alloy lead–lithium as breeder/coolant, such as self-cooled, dual-coolant and helium-cooled lead–lithium blanket concepts. The primary goal of MHD experiments at UCLA using the liquid metal flow facility called MaPLE (Magnetohydrodynamic PbLi Experiment) is to address important MHD effects, heat transfer and flow materials interactions in blanket-relevant conditions. The paper overviews the one-of-a-kind MaPLE loop at UCLA and presents recent experimental activities, including the development and testing of high-temperature PbLi flow diagnostics and experiments that have been performed since the first loop operation in 2011. We also discuss MaPLE upgrades, which need to be done to substantially expand the experimental capabilities towards a new class of MHD flow phenomena that includes buoyancy effects.

MHD PbLi experiments in MaPLE loop at UCLA

Energy Technology Data Exchange (ETDEWEB)

Courtessole, C., E-mail: cyril@fusion.ucla.edu; Smolentsev, S.; Sketchley, T.; Abdou, M.

2016-11-01

Highlights: • The paper overviews the MaPLE facility at UCLA: one-of-a-few PbLi MHD loop in the world. • We present the progress achieved in development and testing of high-temperature PbLi flow diagnostics. • The most important MHD experiments carried out since the first loop operation in 2011 are summarized. - Abstract: Experiments on magnetohydrodynamic (MHD) flows are critical to understanding complex flow phenomena in ducts of liquid metal blankets, in particular those that utilize eutectic alloy lead–lithium as breeder/coolant, such as self-cooled, dual-coolant and helium-cooled lead–lithium blanket concepts. The primary goal of MHD experiments at UCLA using the liquid metal flow facility called MaPLE (Magnetohydrodynamic PbLi Experiment) is to address important MHD effects, heat transfer and flow materials interactions in blanket-relevant conditions. The paper overviews the one-of-a-kind MaPLE loop at UCLA and presents recent experimental activities, including the development and testing of high-temperature PbLi flow diagnostics and experiments that have been performed since the first loop operation in 2011. We also discuss MaPLE upgrades, which need to be done to substantially expand the experimental capabilities towards a new class of MHD flow phenomena that includes buoyancy effects.

Aladağlar’da [Orta Toroslar (Yahyalı-Kayseri)] iki fosil mağara: Zindan-ı Köşk–1 ve Zindan-ı Köşk-2 mağaraları

OpenAIRE

Kopar, İbrahim

2015-01-01

Zindan-ı Köşk-1 ve Zindan-ı Köşk-2 Mağaraları, jeomorfolojik olarak Toros Dağları’nın Orta Toros Bölümü’nün doğusundaki Aladağlarda (en yüksek tepesi 3756 m) yer almaktadır. İdari bakımdan ise Kayseri İlinin Yahyalı ilçesi sınırlarında yer alan mağaralar, naplı yapıya sahip Permiyen kalkerler içinde gelişmiştir. Zindan Deresi’nin 500 metreden fazla yardığı adinin güney yamacında 2095 m ve 2115 metrede giriş ağızları olan mağaralardan üstteki Zindan-ı Köşk-1 Mağarası dikey gelişmiş bir mağara ...

Changing the Safety and Mission Assurance (S and MA) Paradigm

Science.gov (United States)

Malone, Roy W.; Safie, Fayssal M.

2010-01-01

This slide presentation reviews the change in the work and impact of the Safety and Mission Assurance directorate at Marshall Space Flight Center. It reviews the background and the reasons given for a strong Safety & Mission Assurance presence in all planning for space flight. This was pointed out by the Rogers Commission Report after the Space Challenger accident, by the Columbia Accident Investigation Board (CAIB) and by a 2006 NASA Exploration Safety Study (NESS) Team. The overall objective of the work in this area was to improve and maintain S&MA expertise and skills. Training for this work was improved and the S&MA organization was reorganized. This has resulted in a paradigm shift for NASA's safety efforts, which is described. The presentation then reviews the impact of the new S&MA work in the Ares I design and development.

Periodic modulations controlling Kuznetsov–Ma soliton formation in nonlinear Schrödinger equations

Energy Technology Data Exchange (ETDEWEB)

Tiofack, C.G.L., E-mail: glatchio@yahoo.fr [Univ. Lille, CNRS, UMR 8523 – PhLAM – Physique des Lasers Atomes et Molécules, F-59000 Lille (France); Coulibaly, S.; Taki, M. [Univ. Lille, CNRS, UMR 8523 – PhLAM – Physique des Lasers Atomes et Molécules, F-59000 Lille (France); De Bièvre, S.; Dujardin, G. [Univ. Lille, CNRS, UMR 8524 – Laboratoire Paul Painlevé, F-59000 Lille (France); Équipe-Projet Mephysto, INRIA Lille-Nord Europe (France)

2017-06-28

We analyze the exact Kuznetsov–Ma soliton solution of the one-dimensional nonlinear Schrödinger equation in the presence of periodic modulations satisfying an integrability condition. We show that, in contrast to the case without modulation, the Kuznetsov–Ma soliton develops multiple compression points whose number, shape and position are controlled both by the intensity of the modulation and by its frequency. In addition, when this modulation frequency is a rational multiple of the natural frequency of the Kuznetsov–Ma soliton, a scenario similar to a nonlinear resonance is obtained: in this case the spatial oscillations of the Kuznetsov–Ma soliton's intensity are periodic. When the ratio of the two frequencies is irrational, the soliton's intensity is a quasiperiodic function. A striking and important result of our analysis is the possibility to suppress any component of the output spectrum of the Kuznetsov–Ma soliton by a judicious choice of the amplitude and frequency of the modulation. - Highlights: • Exact Kuznetsov–Ma soliton solution in presence of periodic coefficients is obtained. • The multiple compression points of the solution are studied. • The quasi-periodicity of the solution is discussed. • The possibility to suppress any component of the spectrum is analyzed.

PhD on Track – designing learning for PhD students

Directory of Open Access Journals (Sweden)

Gunhild Austrheim

2013-12-01

Full Text Available Three years ago we started the project "Information Management for Knowledge Creation". The project was initiated to create online information literacy modules for PhD students. The result of our endeavours, PhD on Track, will be launched in May 2013. The initial stage of the project was mapping out the information behaviour of PhD students, as well as what services they require from the library through a literature review and a focus group study. The findings of these inquiries formed the knowledge base from which we developed our information literacy modules. Our paper will focus on the interaction between content production and user testing when creating PhD on Track. Methods: User testing has been employed throughout the production stage. We have tested navigation and organisation of the web site, content and usability. The project team have conducted expert testing. Analysis: The results from our user testing have played an important part in decisions concerning content production. Our working hypothesis was that the PhD students would want an encyclopaedic website, a place to quickly find answers. However, the user tests revealed that PhD students understood and expected the website to be learning modules. Conclusions: The PhD students in the tests agreed that a site such as this would be useful, especially to new PhD students. They also liked the design, but had some qualms with the level of information. They preferred shorter text, but with more depth. The students would likewise have preferred more practical examples, more illustrations and more discipline specific information. The current content of PhD on Track reflects the feedback from the user testing. We have retained initial ideas such as one section for reviewing and discovering research literature and one section for publishing PhD research work. In addition, we have included more practical examples to indicate efficient workflows or relevant actions in context. Illustrations

ImpersoNations: cinéma national, imaginaires historiques et nouveau cinéma européen

NARCIS (Netherlands)

Elsaesser, T.

2013-01-01

La question du capital culturel propre à la diversité linguistique de l’Europe reste entière. Quels sont les avantages et les inconvénients de cet éventail de langues dans le cinéma? Les films, quand ils franchissent les frontières, sont souvent doublés. Or, comme un bon jeu d’acteur représente une

Correlating The Star Formation Histories Of MaNGA Galaxies With Their Past AGN Activity

Science.gov (United States)

Gonzalez Ortiz, Andrea

2017-01-01

We investigate active galactic nuclei (AGN) as a primary mechanism affecting star formation in MaNGA galaxies. Using the Pipe3D code, we modeled the stellar population from MaNGA spectra and derived the star formation histories of 53 AGN host galaxies. We seek to compare the star formation histories of the host galaxies of AGN with the ages of their radio lobes to better understand the role of AGN feedback in the star formation histories of MaNGA galaxies. MaNGA (Mapping Nearby Galaxies at APO) is one of the three core programs in the fourth generation Sloan Digital Sky Survey(SDSS). MaNGA will investigate the internal kinematics of nearly 10,000 local galaxies through dithered observations using fiber integral field units (IFUs) that vary in diameter from 12" (19 fibers) to 32" (127 fibers). In this poster, we present initial results on the star formation histories of MaNGA AGN host galaxies. This work was supported by the SDSS Research Experience for Undergraduates program, which is funded by a grant from Sloan Foundation to the Astrophysical Research Consortium.

Ma Ying-jeou’s Presidential Discourse

Directory of Open Access Journals (Sweden)

Jonathan Sullivan

2012-01-01

Full Text Available Despite the substantial advances made in cross-Strait relations during Ma Ying-jeou’s (Ma Yingjiu first term, the ROC president’s rhetoric varied considerably as he grappled with the difficult reality of implementing campaign and inauguration pledges to establish better relations with China while striving to maintain national respect and sovereignty. In this article, we put forward a framework for measuring, analysing and explaining this variation in President Ma’s first-term discourse. Analysing a very large number of Ma’s speeches, addresses, etc., we provide empirical assessments of how the content of Ma’s public pronouncements has developed over time, how his rhetoric varies according to the strategic context and timing of a speech, and how his discourse compares to that of his predecessor, Chen Shui-bian (Chen Shuibian. In addressing these questions, the article contributes a quantitative perspective to existing work on political discourse in Taiwan and to the growing methodological and applied literature on how to systematically analyse Chinese political text.

Qualidade de maçã Fuji osmoticamente concentrada e desidratada Apple Fuji quality osmotically concentrated and dehydrated

Directory of Open Access Journals (Sweden)

V.D.S. GOULARTE

2000-08-01

Full Text Available Maçãs, cv. Fuji, fisiologicamente maduras e super maduras, foram fatiadas na forma de palitos, concentradas osmoticamente e desidratadas, objetivando-se avaliar suas características físicas, químicas e sensoriais. A concentração osmótica foi com soluções a 50% de sacarose, maltodextrina de milho (Mor-rex 1920 e glicose de milho (Excell 1040, sendo os dois últimos produzidos pela Refinações de Milho Brasil. Os palitos de maçãs foram imersos nas soluções concentradoras, por seis horas, drenados e desidratados a 70º C até 10% de umidade pelo controle de peso, seguindo-se armazenamento ambiental em vidros. As avaliações da matéria-prima e produto final foram de umidade, sólidos solúveis totais (º Brix, açúcares, pH, acidez titulável, aceitação pelo consumidor e rendimento. A avaliação estatística dos dados seguiu o delineamento inteiramente ao acaso, com médias submetidas a comparações múltiplas através do teste de Duncan ao nível de 5% de probabilidade. A composição da maçã "in natura" foi similar a encontrada na literatura. Os agentes de concentração osmótica passaram a fazer parte da composição dos produtos desidratados, alterando as características físicas e químicas em ambos estádios de maturação. O rendimento melhorou nos três tratamentos, sendo o melhor com sacarose que, também, resultou na preferência dos consumidores que optaram por "gosto muito", independentemente dos estádios de maturação das maçãs. O estádio de maturação não interferiu nas características dos produtos processados.Physiologically mature and over mature apples, cv. Fuji were sliced in sticks, osmotically concentrated and dehydrated in order to evaluate its physical, chemical and sensorial characteristics. The osmotic concentration was made with syrups at 50% saccharose, corn maltodextrin (Mor-rex 1920 and corn`s glucose (Excell 1040. Both Mor-rex 1920 and Excell 1040 produced by "Refinações de Milho

SCHeMA web-based observation data information system

Science.gov (United States)

Novellino, Antonio; Benedetti, Giacomo; D'Angelo, Paolo; Confalonieri, Fabio; Massa, Francesco; Povero, Paolo; Tercier-Waeber, Marie-Louise

2016-04-01

It is well recognized that the need of sharing ocean data among non-specialized users is constantly increasing. Initiatives that are built upon international standards will contribute to simplify data processing and dissemination, improve user-accessibility also through web browsers, facilitate the sharing of information across the integrated network of ocean observing systems; and ultimately provide a better understanding of the ocean functioning. The SCHeMA (Integrated in Situ Chemical MApping probe) Project is developing an open and modular sensing solution for autonomous in situ high resolution mapping of a wide range of anthropogenic and natural chemical compounds coupled to master bio-physicochemical parameters (www.schema-ocean.eu). The SCHeMA web system is designed to ensure user-friendly data discovery, access and download as well as interoperability with other projects through a dedicated interface that implements the Global Earth Observation System of Systems - Common Infrastructure (GCI) recommendations and the international Open Geospatial Consortium - Sensor Web Enablement (OGC-SWE) standards. This approach will insure data accessibility in compliance with major European Directives and recommendations. Being modular, the system allows the plug-and-play of commercially available probes as well as new sensor probess under development within the project. The access to the network of monitoring probes is provided via a web-based system interface that, being implemented as a SOS (Sensor Observation Service), is providing standard interoperability and access tosensor observations systems through O&M standard - as well as sensor descriptions - encoded in Sensor Model Language (SensorML). The use of common vocabularies in all metadatabases and data formats, to describe data in an already harmonized and common standard is a prerequisite towards consistency and interoperability. Therefore, the SCHeMA SOS has adopted the SeaVox common vocabularies populated by

MaMiCo: Software design for parallel molecular-continuum flow simulations

KAUST Repository

Neumann, Philipp

2015-11-19

The macro-micro-coupling tool (MaMiCo) was developed to ease the development of and modularize molecular-continuum simulations, retaining sequential and parallel performance. We demonstrate the functionality and performance of MaMiCo by coupling the spatially adaptive Lattice Boltzmann framework waLBerla with four molecular dynamics (MD) codes: the light-weight Lennard-Jones-based implementation SimpleMD, the node-level optimized software ls1 mardyn, and the community codes ESPResSo and LAMMPS. We detail interface implementations to connect each solver with MaMiCo. The coupling for each waLBerla-MD setup is validated in three-dimensional channel flow simulations which are solved by means of a state-based coupling method. We provide sequential and strong scaling measurements for the four molecular-continuum simulations. The overhead of MaMiCo is found to come at 10%-20% of the total (MD) runtime. The measurements further show that scalability of the hybrid simulations is reached on up to 500 Intel SandyBridge, and more than 1000 AMD Bulldozer compute cores. Program summary: Program title: MaMiCo. Catalogue identifier: AEYW_v1_0. Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEYW_v1_0.html Program obtainable from: CPC Program Library, Queen\\'s University, Belfast, N. Ireland. Licensing provisions: BSD License. No. of lines in distributed program, including test data, etc.: 67905. No. of bytes in distributed program, including test data, etc.: 1757334. Distribution format: tar.gz. Programming language: C, C++II. Computer: Standard PCs, compute clusters. Operating system: Unix/Linux. RAM: Test cases consume ca. 30-50 MB. Classification: 7.7. External routines: Scons (http:www.scons.org), ESPResSo, LAMMPS, ls1 mardyn, waLBerla. Nature of problem: Coupled molecular-continuum simulation for multi-resolution fluid dynamics: parts of the domain are resolved by molecular dynamics whereas large parts are covered by a CFD solver, e.g. a lattice Boltzmann automaton

The Mesoscale Science of the Matter-Radiation Interactions in Extremes (MaRIE) project

Energy Technology Data Exchange (ETDEWEB)

Kippen, Karen Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Montoya, Donald Raymond [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-08-17

The National Nuclear Security Administration (NNSA) requires the ability to understand and test how material structures, defects, and interfaces determine performance in extreme environments such as in nuclear weapons. To do this, MaRIE will be an x-ray source that is laser-like and brilliant with very fl exible and fast pulses to see at weapons-relevant time scales, and with high enough energy to study critical materials. The Department of Energy (DOE) has determined there is a mission need for MaRIE to deliver this capability. MaRIE can use some of the existing infrastructure of the Los Alamos Neutron Science Center (LANSCE) and its accelerator capability. MaRIE will be built as a strategic partnership of DOE national laboratories and university collaborators.

MA-core loaded untuned RF compression cavity for HIRFL-CSR

International Nuclear Information System (INIS)

Mei Lirong; Xu Zhe; Yuan Youjin; Jin Peng; Bian Zhibin; Zhao Hongwei; Xia Jiawen

2012-01-01

To meet the requirements of high energy density physics and plasma physics research at HIRFL-CSR the goal of achieving a higher accelerating gap voltage was proposed. Therefore, a magnetic alloy (MA)-core loaded radio frequency (RF) cavity that can provide a higher accelerating gap voltage compared to standard ferrite loaded cavities has been studied at IMP. In order to select the proper magnetic alloy material to load the RF compression cavity, measurements of four different kinds of sample MA-cores have been carried out. By testing the small cores, the core composition was selected to obtain the desired performance. According to the theoretical calculation and simulation, which show reasonable consistency for the MA-core loaded cavity, the desired performance can be achieved. Finally about 1000 kW power will be needed to meet the requirements of 50 kV accelerating gap voltage by calculation.

Kuznetsov-Ma waves train generation in a left-handed material

Science.gov (United States)

Atangana, Jacques; Giscard Onana Essama, Bedel; Biya-Motto, Frederick; Mokhtari, Bouchra; Cherkaoui Eddeqaqi, Noureddine; Crépin Kofane, Timoléon

2015-03-01

We analyze the behavior of an electromagnetic wave which propagates in a left-handed material. Second-order dispersion and cubic-quintic nonlinearities are considered. This behavior of an electromagnetic wave is modeled by a nonlinear Schrödinger equation which is solved by collective coordinates theory in order to characterize the light pulse intensity profile. More so, a specific frequency range has been outlined where electromagnetic wave behavior will be investigated. The perfect combination of second-order dispersion and cubic nonlinearity leads to a robust soliton. When the quintic nonlinearity comes into play, it provokes strong and long internal perturbations which lead to Benjamin-Feir instability. This phenomenon, also called modulational instability, induces appearance of a Kuznetsov-Ma waves train. We numerically verify the validity of Kuznetsov-Ma theory by presenting physical conditions which lead to Kuznetsov-Ma waves train generation. Thereafter, some properties of such waves train are also verified.

DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo.

Science.gov (United States)

Zubradt, Meghan; Gupta, Paromita; Persad, Sitara; Lambowitz, Alan M; Weissman, Jonathan S; Rouskin, Silvi

2017-01-01

Coupling of structure-specific in vivo chemical modification to next-generation sequencing is transforming RNA secondary structure studies in living cells. The dominant strategy for detecting in vivo chemical modifications uses reverse transcriptase truncation products, which introduce biases and necessitate population-average assessments of RNA structure. Here we present dimethyl sulfate (DMS) mutational profiling with sequencing (DMS-MaPseq), which encodes DMS modifications as mismatches using a thermostable group II intron reverse transcriptase. DMS-MaPseq yields a high signal-to-noise ratio, can report multiple structural features per molecule, and allows both genome-wide studies and focused in vivo investigations of even low-abundance RNAs. We apply DMS-MaPseq for the first analysis of RNA structure within an animal tissue and to identify a functional structure involved in noncanonical translation initiation. Additionally, we use DMS-MaPseq to compare the in vivo structure of pre-mRNAs with their mature isoforms. These applications illustrate DMS-MaPseq's capacity to dramatically expand in vivo analysis of RNA structure.

Faculty of Law: MaRBLe for Lawyers

NARCIS (Netherlands)

Akkermans, Bram; Bastiaens, Ellen; van Tilburg, Jonathan; van Merriënboer, Jeroen

The Maastricht University Research Based Learning (MaRBLe) project offered a unique but challenging opportunity to the law faculty. Working with undergraduate (or bachelor) students on research was already part of regular, i.e. curricular, teaching activities, but the number of students and

European Master's program in Gerontology (EuMaG): Goals, curriculum, and students

NARCIS (Netherlands)

Aartsen, M.J.

2011-01-01

The European Master's Program in Gerontology (EuMaG) started in September 2003 with support from the European Commission. The EuMaG is a modular, 2-year, part-time international training program about the aging process and its societal implications. The multidisciplinary curriculum comprises four

Alkaline pH sensor molecules.

Science.gov (United States)

Murayama, Takashi; Maruyama, Ichiro N

2015-11-01

Animals can survive only within a narrow pH range. This requires continual monitoring of environmental and body-fluid pH. Although a variety of acidic pH sensor molecules have been reported, alkaline pH sensor function is not well understood. This Review describes neuronal alkaline pH sensors, grouped according to whether they monitor extracellular or intracellular alkaline pH. Extracellular sensors include the receptor-type guanylyl cyclase, the insulin receptor-related receptor, ligand-gated Cl- channels, connexin hemichannels, two-pore-domain K+ channels, and transient receptor potential (TRP) channels. Intracellular sensors include TRP channels and gap junction channels. Identification of molecular mechanisms underlying alkaline pH sensing is crucial for understanding how animals respond to environmental alkaline pH and how body-fluid pH is maintained within a narrow range. © 2015 Wiley Periodicals, Inc.

Millennium Ecosystem Assessment: MA Rapid Land Cover Change

Data.gov (United States)

National Aeronautics and Space Administration — The Millennium Ecosystem Assessment: MA Rapid Land Cover Change provides data and information on global and regional land cover change in raster format for...

Agrobacterium-mediated transient MaFT expression in mulberry (Morus alba L.) leaves.

Science.gov (United States)

Wu, Su-Li; Yang, Xiao-Bing; Liu, Li-Qun; Jiang, Tao; Wu, Hai; Su, Chao; Qian, Yong-Hua; Jiao, Feng

2015-01-01

To optimize Agrobacterium-mediated transient transformation assay in mulberry (Morus alba L.), various infiltration methods, Agrobacterium tumefaciens (A. tumefaciens) strains, and bacterial concentrations were tested in mulberry seedlings. Compared with LBA4404, GV3101 harboring pBE2133 plasmids presented stronger GUS signals at 3 days post infiltration using syringe. Recombinant plasmids pBE2133:GFP and pBE2133:GFP:MaFT were successfully constructed. Transient expression of MaFT:GFP protein was found in leaves, petiole (cross section), and shoot apical meristem (SAM) of mulberry according to the GFP signal. Moreover, MaFT:GFP mRNA was also detected in leaves and SAM via RT-PCR and qRT-PCR. An efficient transient transformation system could be achieved in mulberry seedlings by syringe using A. tumefaciens GV3101 at the OD600 of 0.5. The movement of MaFT expression from leaves to SAM might trigger the precocious flowering of mulberry.

Pu Denaturing by Transmutation of MA in FBR Multi-cycle

Energy Technology Data Exchange (ETDEWEB)

Meiliza, Yoshitalia; Saito, Masaki; Sagara, Hiroshi [Tokyo Institute of Technology, 2-12-1-N1-1 Ookayama, Meguro-ku, Tokyo, 1528550 (Japan)

2009-06-15

Pu accumulation and its recycling is important in the term of energy resources, however one of the most sensitive issues is non-proliferation in the future fuel cycle based on fast breeder reactor (FBR). The present paper utilizes Protected Pu Production (P{sup 3}) concept for the production of {sup 238}Pu and {sup 242}Pu by Minor Actinides (MA) transmutation to enhance the proliferation resistance of Pu in the fuel. Increase in the {sup 238}Pu and {sup 242}Pu isotopic fraction creates a high rate of internal heat generation by alpha decay (DH) and/or a high neutron source of spontaneous fission (SFN) in Pu that would be encountered during manufacturing and maintaining of nuclear explosive device. The feasibility of denaturing of Pu by MA transmutation in medium size FBR has been studied from the viewpoint of even-mass number Pu accumulation during multi-cycle of Pu and MA. The proliferation resistance property of Pu is also evaluated based on the specific decay heat and spontaneous fission neutron, compared with the reference criteria. In present paper, the P{sup 3} technology based on multi-recycled Pu and MA is compared with the conventional technology based on multi-recycled Pu only. The detail of mass balance behavior is, however, beyond the scope of the present paper. (authors)

RuleMaDrone: A Web-Interface to Visualise Space Usage Rules for Drones

OpenAIRE

Trippaers, Aäron

2015-01-01

RuleMaDrone, an application developed within this thesis, is presented as a solution to communicate the rules and regulations to drone operators. To provide the solution a framework for drone safety was designed which consists of the rules and regulations, the drone properties and the environmental factors. RuleMaDrone is developed with this framework and thus will provide drone operators with an application which they can use to find a safe and legal fly zone. RuleMaDrone u...

Identification of AR(I)MA processes for modelling temporal correlations of GPS observations

Science.gov (United States)

Luo, X.; Mayer, M.; Heck, B.

2009-04-01

In many geodetic applications observations of the Global Positioning System (GPS) are routinely processed by means of the least-squares method. However, this algorithm delivers reliable estimates of unknown parameters und realistic accuracy measures only if both the functional and stochastic models are appropriately defined within GPS data processing. One deficiency of the stochastic model used in many GPS software products consists in neglecting temporal correlations of GPS observations. In practice the knowledge of the temporal stochastic behaviour of GPS observations can be improved by analysing time series of residuals resulting from the least-squares evaluation. This paper presents an approach based on the theory of autoregressive (integrated) moving average (AR(I)MA) processes to model temporal correlations of GPS observations using time series of observation residuals. A practicable integration of AR(I)MA models in GPS data processing requires the determination of the order parameters of AR(I)MA processes at first. In case of GPS, the identification of AR(I)MA processes could be affected by various factors impacting GPS positioning results, e.g. baseline length, multipath effects, observation weighting, or weather variations. The influences of these factors on AR(I)MA identification are empirically analysed based on a large amount of representative residual time series resulting from differential GPS post-processing using 1-Hz observation data collected within the permanent SAPOS® (Satellite Positioning Service of the German State Survey) network. Both short and long time series are modelled by means of AR(I)MA processes. The final order parameters are determined based on the whole residual database; the corresponding empirical distribution functions illustrate that multipath and weather variations seem to affect the identification of AR(I)MA processes much more significantly than baseline length and observation weighting. Additionally, the modelling

Türkiye Türkçesinde -ma Ekinin Yapım Eki Olarak İşlevleri / Functions of the Derivative Suffix -ma in Turkey Turkish

Directory of Open Access Journals (Sweden)

Nesrin Bayraktar Erten

2017-12-01

Full Text Available Abstract Functions of the suffix -ma suffix can be classified under three groups in Turkey Turkish. This suffix produces adjectives that are related with root meanings like dönme dolap, sallama çay, gömme dolap, and adjectives like bodoslama atla, silme doldur etc. Besides these functions, it produces permanent nouns like gözleme, sarma, dolma, dondurma, kuzukapama, sürme, etc. This study investigates the suffix -ma as a derivational form and its functions have been classified. The study also evaluates the frequency with which it is used to coin permanent nouns and adjectives.   Öz -ma ekinin Türkiye Türkçesinde işlevlerini başlıca üç grupta toplamak mümkündür. -ma eki ile bir yandan dönme dolap, sallama çay, gömme dolap gibi örneklerde eklendiği eylem tabanıyla ilişkili sıfatlar ve bodoslama atla, silme doldur gibi zarflar yapılırken, öte yandan da gözleme, sarma, dolma, dondurma, kuzukapama, sürme örneklerinde görüldüğü gibi kalıcı adlar yapılmıştır. Kalıcı adlar içinde yemek adları, oldukça önemli bir yer tutmaktadır. Bu çalışmada -ma eki, bir yapım eki olarak değerlendirilecek ve örnekler çerçevesinde tasnif edilerek kalıcı ad ve sıfat yapımında kullanıldığı yerlerdeki sıklık ele alınacaktır.

Efecto de la amonificación sobre el valor nutritivo del ensilaje de maíz

Directory of Open Access Journals (Sweden)

Sánchez G. Hugo

1987-12-01

Full Text Available Mediante la técnica del microsilo, se midió el efecto de niveles de 0, 1, 2 y 3% de NH3 en base a la materia seca sobre el ensilaje de maíz con y sin mazorca. Las variables medidas fueron pH, temperatura, contenido de materia seca (%, contenido de proteína cruda (%, degradabilidad insitu de la materia seca y de la proteína cruda (% a 48 horas de incubación ruminal. Los resultados muestran el efecto benéfico de la amonificación sobre la estabilidad del ensilaje y sobre su valor nutritivo. El análisis económico destaca el beneficio obtenido al ensilar sin mazorca, con los niveles superiores de amonificación.Wich the help of microsilo technique, it was measured the ammonia effect on levels of NH3 of 1, 2 and 3 % through dry matter on the corn ensilage with or without ear of corn. The different measures were pH, temperature, dry matter content (%, protein crude content (% at 48 hours of rumial incubation. The results shows the ammonia beneficent effect on the stability ensilage and on the nutritive value. The economic analysis emphasizes the benefit gotten with out ear of corn ensilage, with the ammonia superior levels, however it 's necessary to rnake sure about the ear of corn market and to have access easiness to the involucred infrastructure in the ammonia process with watery ammonia.

77 FR 29251 - Safety Zone; Carnival Fireworks Display, Nantasket Beach, Hull, MA

Science.gov (United States)

2012-05-17

...-AA00 Safety Zone; Carnival Fireworks Display, Nantasket Beach, Hull, MA AGENCY: Coast Guard, DHS... zone on the navigable waters off of Nantasket Beach in the vicinity of Hull, MA for a Carnival... spectators and vessels from the hazards associated with fireworks displays. Discussion of Proposed Rule Hull...

Rock et cinéma : quelques éléments sur une relation durable

OpenAIRE

Ribac, François

2006-01-01

Générique d’ouverture Le numéro de Volume ! que vous allez lire est consacré aux relations entre le rock et le cinéma. Il est publié au moment où s’ouvre la deuxième édition du Festival Paris-Cinéma. Celui-ci comprend un cycle « rock et cinéma » présenté au cinéma l’Entrepôt, à Paris, du 30 juin au 13 juillet 2004. Si l’on cherche à établir des relations entre les mondes du rock et ceux du cinéma, en voici une première illustration, puisque ce numéro est en effet coproduit par un festival de ...

La fonction de la salle dans les entreprises de promotion de médiation au cinéma : mise en perspective des enjeux du numérique au regard de l’éducation au cinéma

OpenAIRE

Boutin, Perrine

2015-01-01

Si la plupart des dispositifs d’éducation au cinéma en France – comme Ecole et cinéma - considèrent encore la salle de cinéma comme un passage obligatoire, les outils numériques actuels permettent de considérer une autre pratique de la découverte du cinéma.Cette nouvelle considération est décriée par beaucoup de militants de l’éducation au cinéma, qui défendent la salle comme le « lieu naturel du cinéma ». L’article traite la question de savoir si les nouveaux outils numériques engendrent des...

Hypersomnia as presenting symptom of anti-Ma2-associated encephalitis: case study.

Science.gov (United States)

Rojas-Marcos, Iñigo; Graus, Francesc; Sanz, Gema; Robledo, Arturo; Diaz-Espejo, Carlos

2007-01-01

We describe a patient who presented with excessive daytime sleepiness (EDS) and was eventually diagnosed with anti-Ma2 encephalitis. Neurological examination disclosed somnolence, left palpebral ptosis, and vertical gaze paresis. A brain MRI showed high signal intensity in the hypothalamus and each hippocampus. Ma2 antibodies were found in the patient's serum, and fiberbronchoscopy disclosed a lung carcinoma. After three months of steroid treatment, the results of the patient's neurological exam became normal. We conclude that anti-Ma2 encephalitis may present with mostly isolated EDS and that it may respond to steroids despite old age and the presence of an untreated lung cancer.

Ma'atic Beauty: Ethics and Aesthetics of the Ancient Egyptians in Ayi ...

African Journals Online (AJOL)

... Ma'at cannot be disconnected from debates over narratives of anti-colonial and postcolonial conflicts. Indeed, Armah reveals that far from being marooned into a state of archaic, timeless and unchanging tradition, Ma'at has the potential to shape and enhance a sound and inspiring ethical code for nowadays Africans.

Development and tests of fast 1-MA linear transformer driver stages

Directory of Open Access Journals (Sweden)

A. A. Kim

2009-05-01

Full Text Available In this article we present the design and test results of the most powerful, fast linear transformer driver (LTD stage developed to date. This 1-MA LTD stage consists of 40 parallel RLC (resistor R, inductor L, and capacitor C circuits called “bricks” that are triggered simultaneously; it is able to deliver ∼1  MA current pulse with a rise time of ∼100  ns into the ∼0.1-Ohm matched load. The electrical behavior of the stage can be predicted by using a simple RLC circuit, thus simplifying the designing of various LTD-based accelerators. Five 1-MA LTD stages assembled in series into a module have been successfully tested with both resistive and vacuum electron-beam diode loads.

Sr isotope geochemistry of voluminous acidic pyroclastics erupted at 1-3 Ma in Northeast Japan

International Nuclear Information System (INIS)

Shirahase, Teruo; Tamanyu, Shiro; Togashi, Shigeko

1989-01-01

Sr isotope ratios are analyzed for voluminous acidic pyroclastics erupted at 1 - 3 Ma in five areas on the volcanic front of Northeast Japan. The initial values of 87 Sr/ 86 Sr ratios range from 0.7040 to 0.7055. There is no significant difference in ratios between 1 - 3 Ma acidic pyroclastics and 0 - 1 Ma andesitic volcanics in each area in spite of differences in age and in mean SiO 2 content. On the other hand, the ratios in both of 1 - 3 Ma and 0 - 1 Ma volcanics vary along arc in the same manner. The changes of Sr and Rb contents in each area are consistent with systematic changes by fractional crystallization. The low 87 Sr/ 86 Sr ratios and chemistry suggest that 1 - 3 Ma acidic pyroclastics of Northeast Japan formed by a high degree of fractional crystallization from basic magma which is common in genesis with young andesitic volcanism. The mechanisms of the formation of the basic magma and the character of mantle source in each area have not changed for the past 3 Ma. Degrees of fractional crystallization changed with changes of the tectonic condition of shallow magma chamber from a weak horizontal compression stress field to a strong one. (author)

M&A Performance and Economic Impact: Integration and Critical Assessment of Methodological Approach

Directory of Open Access Journals (Sweden)

Karolis Andriuskevicius

2017-11-01

Full Text Available Purpose of the article: Existing methodologies employed within the M&A performance framework are investigated and critically discuss. Methodology/methods: The research has been carried out as a structured assessment of past literature. The findings from scientific articles and studies by various scholars have been categorized, grouped and summarized to discern a meta-analytic view of the work carried out to date. Scientific aim: The conducted research seeks to ascertain and evaluate theoretically existing methodologies used in empirical studies that would allow proper and critical understanding of the results of various findings in the holistic and global M&As area. Findings: The research elaborates on several key developments in M&A methodology and performance studies carried out in empirical works during the last two decades. The findings help to independently and objectively assess performance of M&A from a holistic perspective. Conclusions: Each methodology measuring either M&A performance on a corporate level or effects of M&A on the economy level shall be interpreted and relied on with caution as each of them dispose their limitations whereas application of these methodologies is subject to data availability and case specific.

MaNIDA: an operational infrastructure for shipborne data

Science.gov (United States)

Macario, Ana; Scientific MaNIDA Team

2013-04-01

The Marine Network for Integrated Data Access (MaNIDA) aims to build a sustainable e-Infrastruture to support discovery and re-use of data archived in a distributed network of data providers in Germany (see related abstracts in session ESSI1.2 and session ESSI2.2). Because one of the primary focus of MaNIDA is the underway data acquired on board of German academic research vessels, we will be addressing various issues related to cruise-level metadata, shiptrack navigation, sampling events conducted during the cruise (event logs), standardization of device-related (type, name, parameters) and place-related (gazetteer) vocabularies, QA/QC procedures (near real time and post-cruise validation, corrections, quality flags) as well as ingestion and management of contextual information (e.g. various types of cruise-related reports and project-related information). One of MaNIDA's long-term goal is to be able to offer an integrative "one-stop-shop" framework for management and access of ship-related information based on international standards and interoperability. This access framework will be freely available and is intended for scientists, funding agencies and the public. The master "catalog" we are building currently contains information from 13 German academic research vessels and respective cruises (to date ~1900 cruises with expected growing rate of ~150 cruises annually). Moreover, MaNIDA's operational infrastructure will additionally provide a direct pipeline to SeaDataNet Cruise Summary Report Inventory, among others. In this presentation, we will focus on the extensions we are currently implementing to support automated acquisition and standardized transfer of various types of data from German research vessels to hosts on land. Our concept towards nationwide common QA/QC procedures for various types of underway data (including versioning concept) and common workflows will also be presented. The "linking" of cruise-related information with quality-controlled data

Functional characterization of PhGR and PhGRL1 during flower senescence in the petunia.

Science.gov (United States)

Yang, Weiyuan; Liu, Juanxu; Tan, Yinyan; Zhong, Shan; Tang, Na; Chen, Guoju; Yu, Yixun

2015-09-01

Petunia PhGRL1 suppression accelerated flower senescence and increased the expression of the genes downstream of ethylene signaling, whereas PhGR suppression did not. Ethylene plays an important role in flowers senescence. Homologous proteins Green-Ripe and Reversion to Ethylene sensitivity1 are positive regulators of ethylene responses in tomato and Arabidopsis, respectively. The petunia flower has served as a model for the study of ethylene response during senescence. In this study, petunia PhGR and PhGRL1 expression was analyzed in different organs, throughout floral senescence, and after exogenous ethylene treatment; and the roles of PhGR and PhGRL1 during petunia flower senescence were investigated. PhGRL1 suppression mediated by virus-induced gene silencing accelerated flower senescence and increased ethylene production; however, the suppression of PhGR did not. Taken together, these data suggest that PhGRL1 is involved in negative regulation of flower senescence, possibly via ethylene production inhibition and consequently reduced ethylene signaling activation.

OVERVIEW OF THE SDSS-IV MaNGA SURVEY: MAPPING NEARBY GALAXIES AT APACHE POINT OBSERVATORY

Energy Technology Data Exchange (ETDEWEB)

Bundy, Kevin [Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), Todai Institutes for Advanced Study, the University of Tokyo, Kashiwa 277-8583 (Japan); Bershady, Matthew A.; Wake, David A.; Tremonti, Christy; Diamond-Stanic, Aleksandar M. [Department of Astronomy, University of Wisconsin-Madison, 475 North Charter Street, Madison, WI 53706 (United States); Law, David R.; Cherinka, Brian [Dunlap Institute for Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, Ontario M5S 3H4 (Canada); Yan, Renbin; Sánchez-Gallego, José R. [Department of Physics and Astronomy, University of Kentucky, 505 Rose Street, Lexington, KY 40506-0055 (United States); Drory, Niv [McDonald Observatory, Department of Astronomy, University of Texas at Austin, 1 University Station, Austin, TX 78712-0259 (United States); MacDonald, Nicholas [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Weijmans, Anne-Marie [School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews KY16 9SS (United Kingdom); Thomas, Daniel; Masters, Karen; Coccato, Lodovico [Institute of Cosmology and Gravitation, University of Portsmouth, Portsmouth (United Kingdom); Aragón-Salamanca, Alfonso [School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2RD (United Kingdom); Avila-Reese, Vladimir [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, A.P. 70-264, 04510 Mexico D.F. (Mexico); Badenes, Carles [Department of Physics and Astronomy and Pittsburgh Particle Physics, Astrophysics and Cosmology Center (PITT PACC), University of Pittsburgh, 3941 OHara St, Pittsburgh, PA 15260 (United States); Falcón-Barroso, Jésus [Instituto de Astrofísica de Canarias, E-38200 La Laguna, Tenerife (Spain); Belfiore, Francesco [Cavendish Laboratory, University of Cambridge, 19 J. J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom); and others

2015-01-01

We present an overview of a new integral field spectroscopic survey called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory), one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV) that began on 2014 July 1. MaNGA will investigate the internal kinematic structure and composition of gas and stars in an unprecedented sample of 10,000 nearby galaxies. We summarize essential characteristics of the instrument and survey design in the context of MaNGA's key science goals and present prototype observations to demonstrate MaNGA's scientific potential. MaNGA employs dithered observations with 17 fiber-bundle integral field units that vary in diameter from 12'' (19 fibers) to 32'' (127 fibers). Two dual-channel spectrographs provide simultaneous wavelength coverage over 3600-10300 Å at R ∼ 2000. With a typical integration time of 3 hr, MaNGA reaches a target r-band signal-to-noise ratio of 4-8 (Å{sup –1} per 2'' fiber) at 23 AB mag arcsec{sup –2}, which is typical for the outskirts of MaNGA galaxies. Targets are selected with M {sub *} ≳ 10{sup 9} M {sub ☉} using SDSS-I redshifts and i-band luminosity to achieve uniform radial coverage in terms of the effective radius, an approximately flat distribution in stellar mass, and a sample spanning a wide range of environments. Analysis of our prototype observations demonstrates MaNGA's ability to probe gas ionization, shed light on recent star formation and quenching, enable dynamical modeling, decompose constituent components, and map the composition of stellar populations. MaNGA's spatially resolved spectra will enable an unprecedented study of the astrophysics of nearby galaxies in the coming 6 yr.

OVERVIEW OF THE SDSS-IV MaNGA SURVEY: MAPPING NEARBY GALAXIES AT APACHE POINT OBSERVATORY

International Nuclear Information System (INIS)

Bundy, Kevin; Bershady, Matthew A.; Wake, David A.; Tremonti, Christy; Diamond-Stanic, Aleksandar M.; Law, David R.; Cherinka, Brian; Yan, Renbin; Sánchez-Gallego, José R.; Drory, Niv; MacDonald, Nicholas; Weijmans, Anne-Marie; Thomas, Daniel; Masters, Karen; Coccato, Lodovico; Aragón-Salamanca, Alfonso; Avila-Reese, Vladimir; Badenes, Carles; Falcón-Barroso, Jésus; Belfiore, Francesco

2015-01-01

We present an overview of a new integral field spectroscopic survey called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory), one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV) that began on 2014 July 1. MaNGA will investigate the internal kinematic structure and composition of gas and stars in an unprecedented sample of 10,000 nearby galaxies. We summarize essential characteristics of the instrument and survey design in the context of MaNGA's key science goals and present prototype observations to demonstrate MaNGA's scientific potential. MaNGA employs dithered observations with 17 fiber-bundle integral field units that vary in diameter from 12'' (19 fibers) to 32'' (127 fibers). Two dual-channel spectrographs provide simultaneous wavelength coverage over 3600-10300 Å at R ∼ 2000. With a typical integration time of 3 hr, MaNGA reaches a target r-band signal-to-noise ratio of 4-8 (Å –1 per 2'' fiber) at 23 AB mag arcsec –2 , which is typical for the outskirts of MaNGA galaxies. Targets are selected with M * ≳ 10 9 M ☉ using SDSS-I redshifts and i-band luminosity to achieve uniform radial coverage in terms of the effective radius, an approximately flat distribution in stellar mass, and a sample spanning a wide range of environments. Analysis of our prototype observations demonstrates MaNGA's ability to probe gas ionization, shed light on recent star formation and quenching, enable dynamical modeling, decompose constituent components, and map the composition of stellar populations. MaNGA's spatially resolved spectra will enable an unprecedented study of the astrophysics of nearby galaxies in the coming 6 yr

European Master's Program in Gerontology (EuMaG): Goals, Curriculum, and Students

Science.gov (United States)

Aartsen, Marja

2011-01-01

The European Master's Program in Gerontology (EuMaG) started in September 2003 with support from the European Commission. The EuMaG is a modular, 2-year, part-time international training program about the aging process and its societal implications. The multidisciplinary curriculum comprises four domains of gerontology (i.e., social gerontology,…

Second primary tumor in anti-Ma1/2-positive paraneoplastic limbic encephalitis.

Science.gov (United States)

Leyhe, T; Schüle, R; Schwärzler, F; Gasser, T; Haarmeier, T

2006-05-01

Memory loss can be a symptom of paraneoplastic limbic encephalitis (PLE) a neuropsychiatric disorder associated mostly with small-cell lung cancer and anti-Hu antibodies or with testicular tumors and anti-Ma2 antibodies. We present the case of a patient with temporal coincidence of beginning cognitive decline and diagnosis of a carcinoma of the prostate in whom we diagnosed anti-Ma1/Ma2-positive PLE. The tumor had been completely resected but memory impairment further deteriorated. As the effective treatment of the cancer is considered as the most efficient treatment of a paraneoplastic neurological syndrome (PNS) a second neoplasia was suspected in the patient. By the aid of whole body positron emission tomography with 18-fluorine fluoro-2-deoxy-glucose (FDG-PET) an adenocarcinoma of the cecum could be detected. Two months after surgery anti-Ma antibodies were negative. We conclude that a second neoplasia should be considered, if effective cancer treatment does not lead to improvement or stabilisation of a PNS. Tumor search should be exhaustive and include PET when conventional imaging fails to show a malignancy.

Coral calcifying fluid pH is modulated by seawater carbonate chemistry not solely seawater pH.

Science.gov (United States)

Comeau, S; Tambutté, E; Carpenter, R C; Edmunds, P J; Evensen, N R; Allemand, D; Ferrier-Pagès, C; Tambutté, S; Venn, A A

2017-01-25

Reef coral calcification depends on regulation of pH in the internal calcifying fluid (CF) in which the coral skeleton forms. However, little is known about calcifying fluid pH (pH CF ) regulation, despite its importance in determining the response of corals to ocean acidification. Here, we investigate pH CF in the coral Stylophora pistillata in seawater maintained at constant pH with manipulated carbonate chemistry to alter dissolved inorganic carbon (DIC) concentration, and therefore total alkalinity (A T ). We also investigate the intracellular pH of calcifying cells, photosynthesis, respiration and calcification rates under the same conditions. Our results show that despite constant pH in the surrounding seawater, pH CF is sensitive to shifts in carbonate chemistry associated with changes in [DIC] and [A T ], revealing that seawater pH is not the sole driver of pH CF Notably, when we synthesize our results with published data, we identify linear relationships of pH CF with the seawater [DIC]/[H + ] ratio, [A T ]/ [H + ] ratio and [[Formula: see text

46 CFR 308.521 - Application for Open Cargo Policy, Form MA-301.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Application for Open Cargo Policy, Form MA-301. 308.521... RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.521 Application for Open Cargo Policy, Form MA-301. The standard form of application for a War Risk Open Cargo Policy...

Volcanism at 1.45 Ma within the Yellowstone Volcanic Field, United States

Science.gov (United States)

Rivera, Tiffany A.; Furlong, Ryan; Vincent, Jaime; Gardiner, Stephanie; Jicha, Brian R.; Schmitz, Mark D.; Lippert, Peter C.

2018-05-01

Rhyolitic volcanism in the Yellowstone Volcanic Field has spanned over two million years and consisted of both explosive caldera-forming eruptions and smaller effusive flows and domes. Effusive eruptions have been documented preceding and following caldera-forming eruptions, however the temporal and petrogenetic relationships of these magmas to the caldera-forming eruptions are relatively unknown. Here we present new 40Ar/39Ar dates for four small-volume eruptions located on the western rim of the second-cycle caldera, the source of the 1.300 ± 0.001 Ma Mesa Falls Tuff. We supplement our new eruption ages with whole rock major and trace element chemistry, Pb isotopic ratios of feldspar, and paleomagnetic and rock magnetic analyses. Eruption ages for the effusive Green Canyon Flow (1.299 ± 0.002 Ma) and Moonshine Mountain Dome (1.302 ± 0.003 Ma) are in close temporal proximity to the eruption age of the Mesa Falls Tuff. In contrast, our results indicate a period of volcanism at ca 1.45 Ma within the Yellowstone Volcanic Field, including the eruption of the Bishop Mountain Flow (1.458 ± 0.002 Ma) and Tuff of Lyle Spring (1.450 ± 0.003 Ma). These high-silica rhyolites are chemically and isotopically distinct from the Mesa Falls Tuff and related 1.3 Ma effusive eruptions. The 40Ar/39Ar data from the Tuff of Lyle Spring demonstrate significant antecrystic inheritance, prevalent within the upper welded ash-flow tuff matrix, and minimal within individual pumice. Antecrysts are up to 20 kyr older than the eruption, with subpopulations of grains occurring every few thousand years. We interpret these results as an indicator for the timing of magmatic pulses into a growing magmatic system that would ultimately erupt the Tuff of Lyle Spring, and which we more broadly interpret as the tempo of crustal accumulation associated with bimodal magmatism. We propose a system whereby chemically, isotopically, and temporally distinct, isolated small-volume magma batches are

Caractérisation des systemes de production à base de maïs dans ...

African Journals Online (AJOL)

La présente recherche vise à caractériser les systèmes de production à base de maïs au Bénin pour un appui-conseil ciblé aux producteurs de maïs. La base de sondage est la base de données du sous-projet "Centre National de Spécialisation sur le Maïs", exécuté par l'Institut National des Recherches Agricoles du Bénin ...

Aileler, Öğretmenler ve Dil ve Konuşma Terapistlerinin Çocuklardaki Dil ve Konuşma Bozukluklarına Yönelik Tutum ve Bilgilerinin Değerlendirilmesi

Directory of Open Access Journals (Sweden)

Bülent TOĞRAM

2015-12-01

Full Text Available Çocuklardaki iletişim sorunları aile bildirimleri, öğretmen raporları ve dil ve konuşma terapistleri (DKT tarafından yapılan değerlendirmeler ile saptanmaktadır. Dil ve konuşma bozukluklarının önlenmesi ve terapisinde işbirliği içinde bulunmaları gereken bu üçlü grubun konuya ilişkin görüş ve tutumları alanyazında önemli bulunmaktadır. Bu çalışmanın amacı, ebeveynlerin, öğretmenlerin ve DKT’lerin dil ve konuşma bozuklukları alanındaki sorumluluk ve rollerini nasıl algıladıklarını, dil ve konuşma bozukluğu olan çocuğun akademik ve sosyal başarısına yönelik tutumlarını, dil ve konuşma bozukluklarının nedenleri ve terapisine yönelik düşüncelerini betimlemektir. Çalışmaya 37 aile bireyi, 46 öğretmen ve 35 DKT katılmıştır. Anket yoluyla elde edilen veriler her grubun konuya ilişkin bilgisini ortaya koymak için karşılaştırılmıştır. Dil ve konuşma bozukluğu olan çocukların akademik/sosyal başarılarına yönelik tutumlarında diğer katılımcı gruplara göre öğretmenlerin, çocukların terapi gereksinimlerine yönelik tutumlarında ise ailelerin daha kararsız tutumlar geliştirdikleri dikkat çekmektedir.Dil ve konuşma bozukluklarının nedenleri ve terapi eksikliklerine yönelik bilgilerinde grupların öncelikli sıralamalarının farklılaştığı görülmüştür

Neutron radiographic characteristics of MA-ND type (allyl-diglycol-carbonate) nuclear track detectors

Energy Technology Data Exchange (ETDEWEB)

Ilic, R.; Rant, J.; Humar, M.; Somogyi, G.; Hunyadi, I.

1986-01-01

Neutron radiographic properties of recently developed new nuclear track detectors (MA-ND/..cap alpha.., MA-ND/p and MA-ND/p1), manufactured from allyl diglycol carbonate, were studied. It was found that the quality of radiographic image has an optimum at a removed layer thickness of about 0.8 ..mu..m. The image obtained under this condition is characterized by high detection sensitivity to neutrons (approx. 8.10/sup -3/ tracks/nsub(th) when using B converter) and by excellent inherent unsharpness (approx. 5 ..mu..m) as well as high image contrast (maximum value of net optical density is approx. 1.4).

Genome-Wide Mutation Rate Response to pH Change in the Coral Reef Pathogen Vibrio shilonii AK1.

Science.gov (United States)

Strauss, Chloe; Long, Hongan; Patterson, Caitlyn E; Te, Ronald; Lynch, Michael

2017-08-22

Recent application of mutation accumulation techniques combined with whole-genome sequencing (MA/WGS) has greatly promoted studies of spontaneous mutation. However, such explorations have rarely been conducted on marine organisms, and it is unclear how marine habitats have influenced genome stability. This report resolves the mutation rate and spectrum of the coral reef pathogen Vibrio shilonii , which causes coral bleaching and endangers the biodiversity maintained by coral reefs. We found that its mutation rate and spectrum are highly similar to those of other studied bacteria from various habitats, despite the saline environment. The mutational properties of this marine bacterium are thus controlled by other general evolutionary forces such as natural selection and genetic drift. We also found that as pH drops, the mutation rate decreases and the mutation spectrum is biased in the direction of generating G/C nucleotides. This implies that evolutionary features of this organism and perhaps other marine microbes might be altered by the increasingly acidic ocean water caused by excess CO 2 emission. Nonetheless, further exploration is needed as the pH range tested in this study was rather narrow and many other possible mutation determinants, such as carbonate increase, are associated with ocean acidification. IMPORTANCE This study explored the pH dependence of a bacterial genome-wide mutation rate. We discovered that the genome-wide rates of appearance of most mutation types decrease linearly and that the mutation spectrum is biased in generating more G/C nucleotides with pH drop in the coral reef pathogen V. shilonii . Copyright © 2017 Strauss et al.

PhEDEx Data Service

International Nuclear Information System (INIS)

Egeland, Ricky; Wildish, Tony; Huang, Chih-Hao

2010-01-01

The PhEDEx Data Service provides access to information from the central PhEDEx database, as well as certificate-authenticated managerial operations such as requesting the transfer or deletion of data. The Data Service is integrated with the 'SiteDB' service for fine-grained access control, providing a safe and secure environment for operations. A plug-in architecture allows server-side modules to be developed rapidly and easily by anyone familiar with the schema, and can automatically return the data in a variety of formats for use by different client technologies. Using HTTP access via the Data Service instead of direct database connections makes it possible to build monitoring web-pages with complex drill-down operations, suitable for debugging or presentation from many aspects. This will form the basis of the new PhEDEx website in the near future, as well as providing access to PhEDEx information and certificate-authenticated services for other CMS dataflow and workflow management tools such as CRAB, WMCore, DBS and the dashboard. A PhEDEx command-line client tool provides one-stop access to all the functions of the PhEDEx Data Service interactively, for use in simple scripts that do not access the service directly. The client tool provides certificate-authenticated access to managerial functions, so all the functions of the PhEDEx Data Service are available to it. The tool can be expanded by plug-ins which can combine or extend the client-side manipulation of data from the Data Service, providing a powerful environment for manipulating data within PhEDEx.

Contact Aligner 2 (Front Side): Suss Microtec MA8

Data.gov (United States)

Federal Laboratory Consortium — Description:CORAL Name: SussMA8This system utilizes 1X contact lithography to transfer photomask patterns onto substrates Specifications / Capabilities:UV broadband...

46 CFR 308.409 - Standard form of War Risk Builder's Risk Insurance Policy, Form MA-283.

Science.gov (United States)

2010-10-01

... Policy, Form MA-283. 308.409 Section 308.409 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF... of War Risk Builder's Risk Insurance Policy, Form MA-283. The standard form of War Risk Builder's Risk Insurance Policy, Form MA-283 may be obtained from the American War Risk Agency or MARAD. ...

Industrial chains and innovation activity in Małopolska region in 2008-2010

Directory of Open Access Journals (Sweden)

Świadek Arkadiusz

2014-05-01

Full Text Available Znaczenie powiązań przemysłowych dla aktywności innowacyjnej przedsiębiorstw w regionie małopolskim w latach 2008-2010 Głównym celem prowadzonych badań była próba poszukiwania zmiennych warunków wpływu łańcuchów dostaw na działalność innowacyjną przedsiębiorstw w obrębie wybranego regionalnego systemu przemysłowego, a tym samym określenie warunków brzegowych dla modelu regionalnej sieci innowacji, biorąc pod uwagę specyfikę województwa małopolskiego. Badanie zostało oparte na kwestionariuszu ankietowym i wykonane na grupie 500 firm z Małopolski. W badaniu wykorzystano modelowanie probitowe. Metoda ta jest skutecznym narzędziem analizy dużych, ale statycznych prób, w których zmienna zależna ma charakter jakościowy.

CULTURAL DUE DILIGENCE IN M&A. IMPORTANCE OF SOFT RISKS FACTORS

Directory of Open Access Journals (Sweden)

Iulian Walter

2017-07-01

Full Text Available During the last decades, the corporate world has witnessed a significant rise in the number of cross border mergers and acquisitions (M&As. In cross border M&As, not only different corporate cultures collide, but also different professional and national cultures. The purpose of Cultural Due Diligence (CDD is to get a coherent image of the intercultural challenges of the M&A in order to be aware of the intercultural risks and opportunities. This article aims to reveal the perception of managers involved in the pre-M&A stage on the soft risks factors that need to be investigated during CDD. This study proposes an appraisal of the most important intercultural issues that need to be considered in M&A. Our contribution to the intercultural aspects of M&A literature consists in improving the current understanding of Cultural Due Diligence content.

CULTURAL DUE DILIGENCE IN M&A. IMPORTANCE OF SOFT RISKS FACTORS

Directory of Open Access Journals (Sweden)

Iulian Warter

2017-06-01

Full Text Available During the last decades, the corporate world has witnessed a significant rise in the number of cross border mergers and acquisitions (M&As. In cross border M&As, not only different corporate cultures collide, but also different professional and national cultures. The purpose of Cultural Due Diligence (CDD is to get a coherent image of the intercultural challenges of the M&A in order to be aware of the intercultural risks and opportunities. This article aims to reveal the perception of managers involved in the pre-M&A stage on the soft risks factors that need to be investigated during CDD. This study proposes an appraisal of the most important intercultural issues that need to be considered in M&A. Our contribution to the intercultural aspects of M&A literature consists in improving the current understanding of Cultural Due Diligence content.

Le cinéma comme articulation des différences culturelles : une approche post-coloniale du cinéma brésilien

OpenAIRE

César, Amaranta

2013-01-01

Les concepts d’identité et de nation sont des paradigmes analytiques et critiques qui ont forgé d’importants mouvements cinématographiques comme le Cinema Novo. Le cinéma brésilien est par conséquent un cinéma en recherche de son identité artistique et politique. Mais une telle quête est vouée à l’échec si l’on considère la crise du concept de nation et le renouveau de la notion d’identité. C’est pourquoi je suggère de développer un modèle analytique sur la façon dont les films construisent d...

SDSS-IV/MaNGA: SPECTROPHOTOMETRIC CALIBRATION TECHNIQUE

Energy Technology Data Exchange (ETDEWEB)

Yan, Renbin; Sánchez-Gallego, José R. [Department of Physics and Astronomy, University of Kentucky, 505 Rose St., Lexington, KY 40506-0057 (United States); Tremonti, Christy; Bershady, Matthew A.; Eigenbrot, Arthur; Wake, David A. [Department of Astronomy, University of Winsconsin-Madison, 475 N. Charter Street, Madison, WI 53706-1582 (United States); Law, David R. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Schlegel, David J. [Physics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720-8160 (United States); Bundy, Kevin [Kavli IPMU (WPI), UTIAS, The University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Drory, Niv [McDonald Observatory, Department of Astronomy, University of Texas at Austin, 1 University Station, Austin, TX 78712-0259 (United States); MacDonald, Nicholas [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Bizyaev, Dmitry [Apache Point Observatory, P.O. Box 59, sunspot, NM 88349 (United States); Blanc, Guillermo A. [Departamento de Astronomía, Universidad de Chile, Camino el Observatorio 1515, Las Condes, Santiago (Chile); Blanton, Michael R.; Hogg, David W. [Center for Cosmology and Particle Physics, Department of Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); Cherinka, Brian [Dunlap Institute for Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, Ontario M5S 3H4 (Canada); Gunn, James E. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Harding, Paul [Department of Astronomy, Case Western Reserve University, Cleveland, OH 44106 (United States); Sánchez, Sebastian F., E-mail: yanrenbin@uky.edu [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, A.P. 70-264, 04510 Mexico D.F. (Mexico); and others

2016-01-15

Mapping Nearby Galaxies at Apache Point Observatory (MaNGA), one of three core programs in the Sloan Digital Sky Survey-IV, is an integral-field spectroscopic survey of roughly 10,000 nearby galaxies. It employs dithered observations using 17 hexagonal bundles of 2″ fibers to obtain resolved spectroscopy over a wide wavelength range of 3600–10300 Å. To map the internal variations within each galaxy, we need to perform accurate spectral surface photometry, which is to calibrate the specific intensity at every spatial location sampled by each individual aperture element of the integral field unit. The calibration must correct only for the flux loss due to atmospheric throughput and the instrument response, but not for losses due to the finite geometry of the fiber aperture. This requires the use of standard star measurements to strictly separate these two flux loss factors (throughput versus geometry), a difficult challenge with standard single-fiber spectroscopy techniques due to various practical limitations. Therefore, we developed a technique for spectral surface photometry using multiple small fiber-bundles targeting standard stars simultaneously with galaxy observations. We discuss the principles of our approach and how they compare to previous efforts, and we demonstrate the precision and accuracy achieved. MaNGA's relative calibration between the wavelengths of Hα and Hβ has an rms of 1.7%, while that between [N ii] λ6583 and [O ii] λ3727 has an rms of 4.7%. Using extinction-corrected star formation rates and gas-phase metallicities as an illustration, this level of precision guarantees that flux calibration errors will be sub-dominant when estimating these quantities. The absolute calibration is better than 5% for more than 89% of MaNGA's wavelength range.

SDSS-IV/MaNGA: SPECTROPHOTOMETRIC CALIBRATION TECHNIQUE

International Nuclear Information System (INIS)

Yan, Renbin; Sánchez-Gallego, José R.; Tremonti, Christy; Bershady, Matthew A.; Eigenbrot, Arthur; Wake, David A.; Law, David R.; Schlegel, David J.; Bundy, Kevin; Drory, Niv; MacDonald, Nicholas; Bizyaev, Dmitry; Blanc, Guillermo A.; Blanton, Michael R.; Hogg, David W.; Cherinka, Brian; Gunn, James E.; Harding, Paul; Sánchez, Sebastian F.

2016-01-01

Mapping Nearby Galaxies at Apache Point Observatory (MaNGA), one of three core programs in the Sloan Digital Sky Survey-IV, is an integral-field spectroscopic survey of roughly 10,000 nearby galaxies. It employs dithered observations using 17 hexagonal bundles of 2″ fibers to obtain resolved spectroscopy over a wide wavelength range of 3600–10300 Å. To map the internal variations within each galaxy, we need to perform accurate spectral surface photometry, which is to calibrate the specific intensity at every spatial location sampled by each individual aperture element of the integral field unit. The calibration must correct only for the flux loss due to atmospheric throughput and the instrument response, but not for losses due to the finite geometry of the fiber aperture. This requires the use of standard star measurements to strictly separate these two flux loss factors (throughput versus geometry), a difficult challenge with standard single-fiber spectroscopy techniques due to various practical limitations. Therefore, we developed a technique for spectral surface photometry using multiple small fiber-bundles targeting standard stars simultaneously with galaxy observations. We discuss the principles of our approach and how they compare to previous efforts, and we demonstrate the precision and accuracy achieved. MaNGA's relative calibration between the wavelengths of Hα and Hβ has an rms of 1.7%, while that between [N ii] λ6583 and [O ii] λ3727 has an rms of 4.7%. Using extinction-corrected star formation rates and gas-phase metallicities as an illustration, this level of precision guarantees that flux calibration errors will be sub-dominant when estimating these quantities. The absolute calibration is better than 5% for more than 89% of MaNGA's wavelength range

Anti-Ma-associated encephalitis due to dysgerminoma in a woman with Swyer syndrome.

Science.gov (United States)

Al-Thubaiti, Ibtisam; Al-Hayek, Kefah; Binfalah, Mohammed

2013-04-09

Paraneoplastic limbic encephalitis (PLE)/diencephalitis associated with anti-Ma2 antibodies was linked to testicular cancer and non-small-cell lung cancer (non-SCLC).(1,2) We report a case of anti-Ma-associated PLE/diencephalitis due to dysgerminoma in a woman with gonadal dysgenesis, or Swyer syndrome.

Removal of organic matter and ammoniacal nitrogen from landfill leachate using the UV/H2O2 photochemical process.

Science.gov (United States)

Córdova, Rolando Nunes; Nagel-Hassemer, Maria Eliza; Matias, William Gerson; Muller, Jose Miguel; de Castilhos Junior, Armando Borges

2017-12-04

This study investigates the effects of pH, H 2 O 2 concentration and reaction time of the UV/H 2 O 2 photochemical process on the removal of organic matter and ammonia from biologically pre-treated landfill leachates in anaerobic stabilization ponds. The results show that the concentration of H 2 O 2 and the initial pH are significant factors, with no significant interaction between them. A pH of 3 is the optimum value for the UV/H 2 O 2 process for the removal of organic matter, resulting in 51.63% chemical oxygen demand (COD) removal in addition to the removal of aromatic compounds. The N-NH 3 removal showed little variation between pH values of 1, 5, 7, 11 and 13; the removal was on the order of 16.43 ± 2.00%. The consumption of H 2 O 2 was elevated at pH 9, 11 and 13; at these pH values, the average removal was 94.56 ± 0.43%, compared to 43.07% at pH 3. First-order polynomial models and reaction times on the order of 15 min are sufficient for optimization studies and for evaluation of the effects of the studied parameters. The results of this study support the optimization of the UV/H 2 O 2 process for the removal of organic matter and ammonia from landfill leachates.

Objective determination of pH thresholds in the analysis of 24 h ambulatory oesophageal pH monitoring

NARCIS (Netherlands)

Weusten, B. L.; Roelofs, J. M.; Akkermans, L. M.; vanBerge-Henegouwen, G. P.; Smout, A. J.

1996-01-01

In 24 h oesophageal pH monitoring, pH 4 is widely but arbitrarily used as the threshold between reflux and non-reflux pH values. The aim of the study was to define pH thresholds objectively, based on Gaussian curve fitting of pH frequency distributions. Single-channel 24 h oesophageal pH monitoring

The Data Reduction Pipeline for the SDSS-IV MaNGA IFU Galaxy Survey

Science.gov (United States)

Law, David R.; Cherinka, Brian; Yan, Renbin; Andrews, Brett H.; Bershady, Matthew A.; Bizyaev, Dmitry; Blanc, Guillermo A.; Blanton, Michael R.; Bolton, Adam S.; Brownstein, Joel R.; Bundy, Kevin; Chen, Yanmei; Drory, Niv; D'Souza, Richard; Fu, Hai; Jones, Amy; Kauffmann, Guinevere; MacDonald, Nicholas; Masters, Karen L.; Newman, Jeffrey A.; Parejko, John K.; Sánchez-Gallego, José R.; Sánchez, Sebastian F.; Schlegel, David J.; Thomas, Daniel; Wake, David A.; Weijmans, Anne-Marie; Westfall, Kyle B.; Zhang, Kai

2016-10-01

Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) is an optical fiber-bundle integral-field unit (IFU) spectroscopic survey that is one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV). With a spectral coverage of 3622-10354 Å and an average footprint of ˜500 arcsec2 per IFU the scientific data products derived from MaNGA will permit exploration of the internal structure of a statistically large sample of 10,000 low-redshift galaxies in unprecedented detail. Comprising 174 individually pluggable science and calibration IFUs with a near-constant data stream, MaNGA is expected to obtain ˜100 million raw-frame spectra and ˜10 million reduced galaxy spectra over the six-year lifetime of the survey. In this contribution, we describe the MaNGA Data Reduction Pipeline algorithms and centralized metadata framework that produce sky-subtracted spectrophotometrically calibrated spectra and rectified three-dimensional data cubes that combine individual dithered observations. For the 1390 galaxy data cubes released in Summer 2016 as part of SDSS-IV Data Release 13, we demonstrate that the MaNGA data have nearly Poisson-limited sky subtraction shortward of ˜8500 Å and reach a typical 10σ limiting continuum surface brightness μ = 23.5 AB arcsec-2 in a five-arcsecond-diameter aperture in the g-band. The wavelength calibration of the MaNGA data is accurate to 5 km s-1 rms, with a median spatial resolution of 2.54 arcsec FWHM (1.8 kpc at the median redshift of 0.037) and a median spectral resolution of σ = 72 km s-1.

THE DATA REDUCTION PIPELINE FOR THE SDSS-IV MaNGA IFU GALAXY SURVEY

International Nuclear Information System (INIS)

Law, David R.; Cherinka, Brian; Yan, Renbin; Andrews, Brett H.; Bershady, Matthew A.; Bizyaev, Dmitry; Blanc, Guillermo A.; Blanton, Michael R.; Bolton, Adam S.; Brownstein, Joel R.; Bundy, Kevin; Chen, Yanmei; Drory, Niv; D’Souza, Richard; Jones, Amy; Kauffmann, Guinevere; Fu, Hai

2016-01-01

Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) is an optical fiber-bundle integral-field unit (IFU) spectroscopic survey that is one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV). With a spectral coverage of 3622–10354 Å and an average footprint of ∼500 arcsec 2 per IFU the scientific data products derived from MaNGA will permit exploration of the internal structure of a statistically large sample of 10,000 low-redshift galaxies in unprecedented detail. Comprising 174 individually pluggable science and calibration IFUs with a near-constant data stream, MaNGA is expected to obtain ∼100 million raw-frame spectra and ∼10 million reduced galaxy spectra over the six-year lifetime of the survey. In this contribution, we describe the MaNGA Data Reduction Pipeline algorithms and centralized metadata framework that produce sky-subtracted spectrophotometrically calibrated spectra and rectified three-dimensional data cubes that combine individual dithered observations. For the 1390 galaxy data cubes released in Summer 2016 as part of SDSS-IV Data Release 13, we demonstrate that the MaNGA data have nearly Poisson-limited sky subtraction shortward of ∼8500 Å and reach a typical 10 σ limiting continuum surface brightness μ  = 23.5 AB arcsec −2 in a five-arcsecond-diameter aperture in the g -band. The wavelength calibration of the MaNGA data is accurate to 5 km s −1 rms, with a median spatial resolution of 2.54 arcsec FWHM (1.8 kpc at the median redshift of 0.037) and a median spectral resolution of σ  = 72 km s −1 .

Antioxidative effects in vivo and colonization of Lactobacillus plantarum MA2 in the murine intestinal tract.

Science.gov (United States)

Tang, Wei; Xing, Zhuqing; Hu, Wei; Li, Chao; Wang, Jinju; Wang, Yanping

2016-08-01

Lactobacillus plantarum MA2 was isolated from traditional Chinese Tibet kefir grains, which possess several excellent properties and functions. We previously demonstrated the antioxidant activities of this bacterium in vitro. However, the maintenance and survival of L. plantarum MA2 inside the murine intestinal tract, where it exerts its probiotic properties, and whether its effects are elicited directly on the host remain unknown. Therefore, this study investigated the mechanisms of L. plantarum MA2 in aging mice following D-galactose administration. The levels of malondialdehyde decreased significantly in the L. plantarum MA2 groups after oral ingestion compared to the D-galactose model group, and total antioxidant capacity and glutathione peroxidase and superoxide dismutase activities increased significantly in the serum and liver. We combined fluorescein isothiocyanate labeling and green fluorescent protein expression to dynamically monitor the colonization and distribution of L. plantarum MA2 in the murine intestinal tract. The results indicated that L. plantarum MA2 was detected in the ileum, colon, and feces after single and continuous oral administration at day 21 and was maintained at 10(4)-10(5) CFU/g. These results suggest that L. plantarum MA2 colonizes and survives in the murine intestinal tract to exert its antioxidative effects.

Narcolepsy, REM sleep behavior disorder, and supranuclear gaze palsy associated with Ma1 and Ma2 antibodies and tonsillar carcinoma.

Science.gov (United States)

Adams, Chris; McKeon, Andrew; Silber, Michael H; Kumar, Rajeev

2011-04-01

To describe a patient with diencephalic and mesencephalic presentation of a Ma1 and Ma2 antibody-associated paraneoplastic neurological disorder. Case report. The Colorado Neurological Institute Movement Disorders Center in Englewood, Colorado, and the Mayo Clinic in Rochester, Minnesota. A 55-year-old man with a paraneoplastic neurological disorder characterized by rapid eye movement sleep behavior disorder, narcolepsy, and a progressive supranuclear palsy-like syndrome in the setting of tonsillar carcinoma. Immunotherapy for paraneoplastic neurological disorder, surgery and radiotherapy for cancer, and symptomatic treatment for parkinsonism and sleep disorders. Polysomnography, multiple sleep latency test, and neurological examination. The cancer was detected at a limited stage and treatable. After oncological therapy and immunotherapy, symptoms stabilized. Treatment with modafinil improved daytime somnolence. Rapid onset and progression of multifocal deficits may be a clue to paraneoplastic etiology. Early treatment of a limited stage cancer (with or without immunotherapy) may possibly slow progression of neurological symptoms. Symptomatic treatment may be beneficial.

In vitro synthesis and purification of PhIP-deoxyguanosine and PhIP-DNA oligomer covalent complexes

Energy Technology Data Exchange (ETDEWEB)

Freeman, J.

1994-12-01

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic amine compound formed when meats are cooked at high temperatures. PhIP damages DNA by forming covalent complexes with DNA carcinogen. In an effort to understand how the binding of PhIP to DNA may cause cancer, it is important to characterize the structures of PhIP-damaged DNA molecules. Our HPLC data support fluorescence and {sup 32}P Post-labeling studies which indicate the formation of several species of 2{prime}deoxyguanosine-(dG) or oligodeoxynucleotide-PhIP adducts. The reaction of PhIP with dG resulted in a reddish precipitate that was likely the major adduct, N-(deoxyguanosin-8-yl)-PhIP (dG-C8-PhIP) adduct, with a more polar adduct fraction remaining in the supernatant. Reversed-phase HPLC analysis of the adducts in the supernatant revealed the existence of species of much shorter retention times than the dG-C8-PhIP adduct, confirming that these species are more polar than dG-C8-PhIP. At least four adducts were formed in the reaction of PhIP with DNA oligomer. HPLC analysis of the PhIP-DNA oligomer supernatant after butanol extractions revealed four unresolved peaks which spectra had maximum wavelengths between 340 and 360 nm. Though adduct peaks were not completely resolved, there was {approximately}3 minutes interval between the DNA oligomer peak and the adduct peaks. Furthermore, fluorescence emission data of the DNA oligomer-PhIP adduct solution show heterogeneous binding. The more polar PhIP adducts were fraction-collected and their structures will be solved by nuclear magnetic resonance or x-ray crystallography.

Schéma directeur des Systèmes d'information 2012-2016

OpenAIRE

Institut National de Recherche Agronomique UAR 0776 Administration du siège

2012-01-01

Le schéma directeur des systèmes d’information de l’inra est le premier Schéma directeur dont l’institut se dote dans le champ des systèmes D’information. Il couvre la période 2012‐2016 du contrat d’objectifs Et s’inscrit dans les perspectives scientifiques dressées par le document D’orientation 2010‐2020

China's Overseas M&A in Global Economic Crisis

Institute of Scientific and Technical Information of China (English)

Han Kang

2009-01-01

@@ verseas Merger and Acquisition (M&A) is not only the major means for the enterprises to expand rapid-ly and operate globally, but also the significant stra-tegic tools for acquiring advanced technotegy from other companies and seizing the market and other resources.

Konsep Pendidikan Akhlak dan Dakwah dalam Perspektif Dr. KH. Zakky Mubarak, MA

Directory of Open Access Journals (Sweden)

Muchtar Muchtar

2017-09-01

Full Text Available Research aims to understand role, and the concept of education and dakwah in perspective Dr. KH. Zakky Mubarak, MA. This research departs from looking at the phenomenon of human life is increasingly complex, entered the modern life and globalization present and the future, wich is characterized by technical and professional paced lives, is forecast to many people ignore the moral and religious in individual and social life. The concept of moral education in the perspective of Dr. KH. Zakky Mubarak, MA that establishes the character of the learners, provide good role models, develop the moral high level, and then apply the knowledge of good character and exemplary in real life so it can become an ingrained habit. The concept of dakwah in perspective Dr. KH. Zakky Mubarak, MA at least two steps that need to be understood by a preacher, first that of bringing the wisdom, it means explaining the wisdoms contained in worship and other Islamic activities without patronizing impression, meaning a preacher should put the words and appropriate sentence appropriate to the circumstances . The second is to mau'idlah hasanah , means giving advice that touch the heart so that the message can be embedded in the memories of audience. Dr. KH. Zakky Mubarak, MA is one of the Nahdlatul Ulama cleric who spend their time preaching, either through a lecture or through scientific papers, scientific papers written contains a lot of moral education that can be used as a reference.  Keywords: Concept of Education and Dakwah, Zakky Mubarak, Nahdlatul Ulama Abstrak Penelitian ini bertujuan untuk mengetahui peran, serta konsep pendidikan akhlak dan dakwah dalam perspektif Dr. KH. Zakky Mubarak, MA. Kesimpulan penelitian ini bahwa Konsep pendidikan akhlak dalam perspektif Dr. KH. Zakky Mubarak, MA yaitu menanamkan pemahaman tentang akhlak terhadap peserta didik, memberikan keteladanan yang baik, mengembangkan pada akhlak tingkat tinggi, dan kemudian mengaplikasikan

Post 4 Ma initiation of normal faulting in southern Tibet. Constraints from the Kung Co half graben

Science.gov (United States)

Mahéo, G.; Leloup, P. H.; Valli, F.; Lacassin, R.; Arnaud, N.; Paquette, J.-L.; Fernandez, A.; Haibing, L.; Farley, K. A.; Tapponnier, P.

2007-04-01

The timing of E-W extension of the Tibetan plateau provides a test of mechanical models of the geodynamic evolution of the India-Asia convergence zone. In this work we focus on the Kung Co half graben (Southern Tibet, China), bounded by an active N-S normal fault with a minimum vertical offset of 1600 m. To estimate the onset of normal faulting we combined high and medium temperature (U-Pb, Ar/Ar) and low temperature ((U-Th)/He) thermochronometry of the Kung Co pluton, a two-mica granite of the northern Himalayan granitic belt that outcrop in the footwall of the fault. Biotite and muscovite Ar/Ar ages , are close from each other [˜ 16 Ma ± 0.2 (Ms) and ˜ 15 ± 0.4 Ma (Bt)], which is typical of fast cooling. The zircon and apatite (U-Th)/He ages range from 11.3 to 9.6 Ma and 9.9 to 3.7 Ma respectively. These He ages are indicative of (1) fast initial cooling, from 11.3 to ˜ 9 Ma, gradually decreasing with time and (2) a high geothermal gradient (˜ 400 °C/km), close to the surface at ˜ 10 Ma. The Kung Co pluton was emplaced at about 22 Ma (U-Pb on zircon) at less than 10 km depth and 520-545 °C. Subsequent to its shallow emplacement, the pluton underwent fast thermal re-equilibration ending around 7.5 Ma, followed by a period of slow cooling caused either by the end of the thermal re-equilibration or by very slow exhumation (0.02-0.03 mm/yr) from ˜ 7.5 Ma to at least 4 Ma. In either case the data suggest that the exhumation rate increased after 4 Ma. We infer this increase to be related to the initiation of the Kung Co normal fault. A critical examination of previously published data show that most ˜ N-S Tibetan normal faults may have formed less than 5 Ma ago rather than in the Miocene as assumed by several authors. Such a young age implies that E-W extension is not related to the Neogene South Tibetan magmatism (25 to 8 Ma). Consequently, models relating E-W extension to magmatism, such as convective removal of the lower lithosphere, may be inappropriate

The PhD by Publication

Directory of Open Access Journals (Sweden)

Susi Peacock

2017-07-01

Full Text Available Aim/Purpose: The purpose of this work is to develop more nuanced understandings of the PhD by publication, particularly raising awareness of the retrospective PhD by publication. The article aims to contribute to contemporary debates about the differing pathways to the attainment of doctoral study completion and the artifacts submitted for that purpose. It also seeks to support prospective graduate students and supervisors who are embarking upon alternative routes to doctoral accreditation. Background: The PhD is considered the pinnacle of academic study – highly cherished, and replete with deeply held beliefs. In response to changes in job markets, developments in the disciplines, and more varied student cohorts, diverse pathways to completion of this award have emerged, such as the PhD by publication (PhDP. A PhDP may either be prospective or retrospective. For the former, publications are planned and created with their contributions to the PhDP in mind. The retrospective PhD is assembled after some, or most, of the publications have been completed. The artifact submitted for examination in this case consists of a series of peer-reviewed academic papers, books, chapters, or equivalents that have been published or accepted for publication, accompanied by an over-arching narrative. The retrospective route is particularly attractive for professionals who are research-active but lack formal academic accreditation at the highest level. Methodology: This article calls upon a literature review pertaining to the award of PhDP combined with the work of authors who offer their personal experiences of the award. The author also refers to her candidature as a Scottish doctoral student whilst studying for the award of PhD by publication. Contribution: This work raises awareness of the PhDP as a credible and comparable pathway for graduate students. The article focuses upon the retrospective PhDP which, as with all routes to doctoral accreditation, has

Preliminary experiments to estimate the PE.MA.M (PElagic MArine Mesocosm) offshore behaviour

Science.gov (United States)

Albani, Marta; Piermattei, Viviana; Stefanì, Chiara; Marcelli, Marco

2016-04-01

The phytoplankton community is controlled not only by local environmental conditions but also by physical processes occurring on different temporal and spatial scales. Hydrodynamic local conditions play an important role in marine ecosystems. Several studies have shown that hydrodynamic conditions can influence the phytoplankton settling velocity, vertical and horizontal distribution and formation of cyanobacterial blooms. Mesocosms are useful structures to simulate marine environment at mesoscale resolution; allowing to closely approximate biotic or abiotic parameters of interest directly in nature. In this work an innovative structure named PE.MA.M (PElagic MArine Mesocosm) is presented and tested. Laboratory experiments have been conducted in order to observe seasonal variations of biomass behaviour in two different hydrodynamic conditions: outside as well as whithin the PE.MA.M. We have evaluated whether it is possible to isolate a natural system from external water mass hydrodynamic exchanges and to assume that phytoplankton cells' transition is limited at the net and sea interface. Preliminary experiments test the isolating capacity of the net, to determine the currents' attenuation rate and to estimate the possible PE.MA.M. offshore behaviour. In the first investigation, we monitored the diffusion of phytoplankton cells. The PE.MA.M. exterior and interior were simulated using a plexiglass tank divided into two half-tanks (Aout-Bin) by a septum consisting of a net like a PE.MA.M. The tank was filled up with 10 L of water and only the half-tank Aout was filled up with 10 ml of phytoplankton culture (Clorella sp.). We monitored the chlorophyll concentrations for 24 hours. The two tanks had similar concentrations after 4 hours (2.70322 mg/m³ Aout and 2.37245 mg/m3 Bin) and this constant relationship was maintened until the end of the test. In the second investigation we used clod cards to measure water motions.We conducted two experiments within tank, the first

46 CFR 308.522 - Collateral deposit fund, letter of transmittal, Form MA-302.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Collateral deposit fund, letter of transmittal, Form MA... Collateral deposit fund, letter of transmittal, Form MA-302. The standard form of letter of transmittal for use in establishing a collateral deposit fund, may be obtained from the American War Risk Agency or...

Continuous pH monitoring in a perfused bioreactor system using an optical pH sensor

Science.gov (United States)

Jeevarajan, Antony S.; Vani, Sundeep; Taylor, Thomas D.; Anderson, Melody M.

2002-01-01

Monitoring and regulating the pH of the solution in a bioprocess is one of the key steps in the success of bioreactor operation. An in-line optical pH sensor, based on the optical absorption properties of phenol red present in the medium, was developed and tested in this work for use in NASA space bioreactors based on a rotating wall-perfused vessel system supporting a baby hamster kidney (BHK-21) cell culture. The sensor was tested over three 30-day and one 124-day cell runs. The pH sensor initially was calibrated and then used during the entire cell culture interval. The pH reported by the sensor was compared to that measured by a fiber optically coupled Shimadzu spectrophotometer and a blood gas analyzer. The maximum standard error of prediction for all the four cell runs for development pH sensor against BGA was +/-0.06 pH unit and for the fiber optically coupled Shimadzu spectrophotometer against the blood gas analyzer was +/-0.05 pH unit. The pH sensor system performed well without need of recalibration for 124 days. Copyright 2002 Wiley Periodicals, Inc.

THE DATA REDUCTION PIPELINE FOR THE SDSS-IV MaNGA IFU GALAXY SURVEY

Energy Technology Data Exchange (ETDEWEB)

Law, David R. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Cherinka, Brian [Center for Astrophysical Sciences, Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD 21218 (United States); Yan, Renbin [Department of Physics and Astronomy, University of Kentucky, 505 Rose Street, Lexington, KY 40506-0055 (United States); Andrews, Brett H. [Department of Physics and Astronomy and PITT PACC, University of Pittsburgh, 3941 O’Hara Street, Pittsburgh, PA 15260 (United States); Bershady, Matthew A. [Department of Astronomy, University of Wisconsin-Madison, 475 N. Charter Street, Madison, WI 53706 (United States); Bizyaev, Dmitry [Apache Point Observatory, P.O. Box 59, Sunspot, NM 88349 (United States); Blanc, Guillermo A. [Departamento de Astronomía, Universidad de Chile, Camino del Observatorio 1515, Las Condes, Santiago (Chile); Blanton, Michael R. [Center for Cosmology and Particle Physics, Department of Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); Bolton, Adam S.; Brownstein, Joel R. [Department of Physics and Astronomy, University of Utah, 115 S 1400 E, Salt Lake City, UT 84112 (United States); Bundy, Kevin [Kavli Institute for the Physics and Mathematics of the universe, Todai Institutes for Advanced Study, the University of Tokyo, Kashiwa, 277-8583 (Kavli IPMU, WPI) (Japan); Chen, Yanmei [School of Astronomy and Space Science, Nanjing University, Nanjing 210093 (China); Drory, Niv [McDonald Observatory, Department of Astronomy, University of Texas at Austin, 1 University Station, Austin, TX 78712-0259 (United States); D’Souza, Richard; Jones, Amy; Kauffmann, Guinevere [Max Planck Institute for Astrophysics, Karl-Schwarzschild-Str. 1, D-85748 Garching (Germany); Fu, Hai, E-mail: dlaw@stsci.edu [Department of Physics and Astronomy, University of Iowa, Iowa City, IA 52242 (United States); and others

2016-10-01

Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) is an optical fiber-bundle integral-field unit (IFU) spectroscopic survey that is one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV). With a spectral coverage of 3622–10354 Å and an average footprint of ∼500 arcsec{sup 2} per IFU the scientific data products derived from MaNGA will permit exploration of the internal structure of a statistically large sample of 10,000 low-redshift galaxies in unprecedented detail. Comprising 174 individually pluggable science and calibration IFUs with a near-constant data stream, MaNGA is expected to obtain ∼100 million raw-frame spectra and ∼10 million reduced galaxy spectra over the six-year lifetime of the survey. In this contribution, we describe the MaNGA Data Reduction Pipeline algorithms and centralized metadata framework that produce sky-subtracted spectrophotometrically calibrated spectra and rectified three-dimensional data cubes that combine individual dithered observations. For the 1390 galaxy data cubes released in Summer 2016 as part of SDSS-IV Data Release 13, we demonstrate that the MaNGA data have nearly Poisson-limited sky subtraction shortward of ∼8500 Å and reach a typical 10 σ limiting continuum surface brightness μ  = 23.5 AB arcsec{sup −2} in a five-arcsecond-diameter aperture in the g -band. The wavelength calibration of the MaNGA data is accurate to 5 km s{sup −1} rms, with a median spatial resolution of 2.54 arcsec FWHM (1.8 kpc at the median redshift of 0.037) and a median spectral resolution of σ  = 72 km s{sup −1}.

Reconstruction of Northeast Asian Deformation Integrated with Western Pacific Plate Subduction since 200 Ma

Science.gov (United States)

Liu, S.; Gurnis, M.; Ma, P.; Zhang, B.

2017-12-01

The configuration and kinematics of continental deformation and its marginal plate tectonics on the Earth's surface are intrinsic manifestations of plate-mantle coupling. The complex interactions of plate boundary forces result in plate motions that are dominated by slab pull and ridge push forces and the effects of mantle drag; these interactions also result in continental deformation with a complex basin-mountain architecture and evolution. The kinematics and evolution of the western Pacific subduction and northeast Asian continental-margin deformation are a first-order tectonic process whose nature and chronology remains controversial. This paper implements a "deep-time" reconstruction of the western Pacific subduction, continental accretion or collision and basin-mountain deformation in northeast Asia since 200 Ma based on a newly revised global plate model. The results demonstrate a NW-SE-oriented shortening from 200-137 Ma, a NWW-SEE-oriented extension from 136-101 Ma, a nearly N-S-oriented extension and uplift with a short-term NWW-SEE-oriented compressional inversion in northeast China from 100-67 Ma, and a NW-SE- and nearly N-S-oriented extension from 66 Ma to the present day. The western Pacific oceanic plate subducted forward under East Asia along Mudanjiang-Honshu Island during the Jurassic, and the trenches retreated to the Sikhote-Alin, North Shimanto, and South Shimanto zones from ca. 137-128 Ma, ca. 130-90 Ma, and in ca. 60 Ma, respectively. Our time-dependent analysis of plate motion and continental deformation coupling suggests that the multi-plate convergent motion and ocean-continent convergent orogeny were induced by advance subduction during the Jurassic and earliest Cretaceous. Our analysis also indicates that the intra-continent rifting and back-arc extension were triggered by trench retreat during the Cretaceous and that the subduction of oceanic ridge and arc were triggered by trench retreat during the Cenozoic. Therefore, reconstructing

Izsoļu sistēma uz satvara “Laravel”

OpenAIRE

Kasparsons, Reinis

2015-01-01

Darbā aprakstīta informācijas sistēma, kas paredzēta uzņēmumam, kuram nepieciešama vienkārša izsoļu sistēma pakalpojumu un preču izsolei. Sistēmas klientiem tā nodrošina produkta iegādes iespēju, bet pārdevējam savu produktu un pakalpojumu vienkāršu izsoli. Sistēmas realizācija datu glabāšanai izmanto datubāzi ar SQL pieeju. Lietotāju skati tiek veidoti, izmantojot PHP, HTML5,CSS3,Bootstrap un Laravel.

Klasifikasi Kecamatan Berdasarkan Nilai Akhir SMA/MA di Kabupaten Aceh Selatan Menggunakan Analisis Diskriminan

Directory of Open Access Journals (Sweden)

Fitriana A.R.

2015-11-01

Full Text Available Analisis diskriminan merupakan bagian dari analisis peubah ganda. Analisis diskriminan digunakan untuk memodelkan variabel tak bebas yang bersifat kualitatif dengan variabel bebas yang bersifat kuantitatif. Pada penelitian ini, analisis diskriminan lebih dari dua kelompok diterapkan pada data nilai akhir SMA/MA di Kabupaten Aceh Selatan yang bertujuan untuk mendapatkan model untuk pengklasifikasian kecamatan. Pengklasifikasian ini bertujuan untuk melihat perbedaan kualitas siswa SMA/MA yang berada di masing-masing kecamatan Kabupaten Aceh Selatan berdasarkan data nilai akhir. Variabel tak bebas yang digunakan berupa klasifikasi kecamatan berdasarkan rata-rata jumlah nilai akhir SMA/MA yang berada di masing-masing kecamatan yang dibentuk dengan K-Means Cluster. Sedangkan variabel bebas yang digunakan adalah data rata-rata nilai akhir SMA/MA untuk setiap mata pelajaran yang diujiankan pada masing-masing jurusan setiap kecamatan. Model yang didapatkan adalah dua model diskriminan untuk jurusan IPA dan IPS.

Fabrication technology for ODS Alloy MA957

International Nuclear Information System (INIS)

ML Hamilton; DS Gelles; RJ Lobsinger; MM Paxton; WF Brown

2000-01-01

A successful fabrication schedule has been developed at Carpenter Technology Corporation for the production of MA957 fuel and blanket cladding. Difficulties with gun drilling, plug drawing and recrystallization were overcome to produce a pilot lot of tubing. This report documents the fabrication efforts of two qualified vendors and the support studies performed at WHC to develop the fabrication-schedule

Organisational Learning through International M&A Integration Strategies

Science.gov (United States)

Holland, Wayne; Salama, Alzira

2010-01-01

Purpose: The purpose of this research paper is to explore the learning process associated with international mergers and acquisitions (M&A) integration strategies. Design/methodology/approach: The paper employs a comparative case study methodology, utilising qualitative data through in-depth interviews with top management responsible for…

Second Generation Dutch Pulsar Machine - PuMa-II

NARCIS (Netherlands)

Karuppusamy, Ramesh; Stappers, Ben; Slump, Cornelis H.; van der Klis, Michiel

2004-01-01

The Second Generation Pulsar Machine (PuMa- II) is under development for the Westerbork Synthesis Radio Telescope. This is a summary of th e system design and architecture. We show that state of the art pulsar research is possible with commercially available hardware components. This approach

Molecular mechanisms and in vitro antioxidant effects of Lactobacillus plantarum MA2.

Science.gov (United States)

Tang, Wei; Xing, Zhuqing; Li, Chao; Wang, Jinju; Wang, Yanping

2017-04-15

Lactobacillus plantarum MA2 was isolated from Chinese traditional Tibetan kefir grains. The antioxidant activities in vitro of this strain were evaluated extensively. The results showed that L. plantarum MA2 can tolerate hydrogen peroxide up to 2.0mM, and its fermentate (fermented supernatant, intact cell and cell-free extract) had strong reducing capacities, lipid peroxidation inhibition capacities, Fe 2+ -chelating abilities, as well as various free radical scavenging capacities. Additionally, both the fermented supernatant and cell homogenate exhibited glutathione peroxidase activity and superoxide dismutase activity. In order to investigate the antioxidant mechanism of L. plantarum MA2 at the molecular level, eight antioxidant-related genes were identified, and further analyzed. Three groups of genes cat, gshR and npx, were found up-regulated under H 2 O 2 challenge. Copyright © 2016 Elsevier Ltd. All rights reserved.

Flux consumption optimization and the achievement of 1 MA discharges on NSTX

International Nuclear Information System (INIS)

Menard, J.; LeBlanc, B.; Sabbagh, S.A.

2001-01-01

The spherical tokamak (ST), because of its slender central column, has very limited volt-second capability relative to a standard aspect ratio tokamak of similar plasma cross-section. Recent experiments on the National Spherical Torus Experiment (NSTX) have begun to quantify and optimize the ohmic current drive efficiency in a MA-class ST device. Sustainable ramp-rates in excess of 5MA/sec during the current rise phase have been achieved on NSTX, while faster ramps generate significant MHD activity. Discharges with I P exceeding 1MA have been achieved in NSTX with nominal parameters: aspect ratio A=1.3-1.4, elongation κ=2-2.2, triangularity δ=0.4, internal inductance l i =0.6, and Ejima coefficient C E =0.35. Flux consumption efficiency results, performance improvements associated with first boronization, and comparisons to neoclassical resistivity are described. (author)

pH sensor calibration procedure

OpenAIRE

Artero Delgado, Carola; Nogueras Cervera, Marc; Manuel Lázaro, Antonio; Prat Tasias, Jordi; Prat Farran, Joana d'Arc

2013-01-01

This paper describes the calibration of pH sensor located at the OBSEA marine Observatory. This instrument is based on an industrial pH electrode that is connected to a CTD instrument (Conductivity, Temperature, and Depth ). The calibration of the pH sensor has been done using a high precision spectrophotometer pH meter from Institute of Marine Sciences (ICM), and in this way it has been obtained a numerical function for the p H sensor propor...

TRANSFORMASI KURIKULUM PESANTREN: Telaah Pemikiran KH. MA. Sahal Mahfudh dan Nurcholish Madjid

OpenAIRE

Mukhlison Effendi; Suradi Suradi

2016-01-01

Abstract; Islamic boarding school is an indigenous Indonesia. Some contribution that given in the Islamization process, create a good community literacy and culture are very large. One reason, because there are Islamic boarding school curriculum transformation. Most influential enticement are KH. MA. Sahal Mahfudh and Nurcholish Madjid enticement. To knowing and determine the transformation both of those figures, the researcher take focus of study as: 1) the speculation of KH. MA. Sahal Mahfu...

Origin Of Black Shale (Marl) Formation Aided By Continuous Volcanism For 10Ma Including Oceanic Anoxic Event, OAE2 (93-93.5 Ma) In The Eagle Ford Formation In South Texas

Science.gov (United States)

Chakrabarty, P.; Basu, A. R.

2017-12-01

We report LA-ICPMS U-Pb ages and Hf isotopes of zircons, petrography, major and trace elements and X-ray diffraction (XRD) analyses of whole rock black shales(marls) from volcanic subsurface as well as surface exposure ash beds of the Eagle Ford and Boquillas Formations in South Texas. Zircons from the middle part of the 300ft long Eagle Ford cores yield ages of 93.2±1.66 Ma, 94.13±1.25 Ma and 93.7±1.9 Ma. These ages are consistent with the Cenomanian-Turonian (C-T) age of deposition in three contiguous cores with spatial separation of 140 miles. An approximate 10Ma duration of deposition of volcanic ash and marl, at a rate of 28ft/Ma for the Eagle Ford is suggested from the 85.76 to 95.5 Ma ages. These ages are from the Eagle Ford ash beds, below the Austin Chalk and above the Buda Limestone and cover the Oceanic Anoxic Event 2 at the C-T boundary. Zircons from 7 ash beds in the surface exposures of the Boquillas Formation near Del Rio, yield ages between 84.63 Ma - 90.91 Ma, implying younger than C-T boundary ages for these samples. The mineralogy, major and trace elements of the ash beds suggest their source from nearby arc-derived calc-alkaline volcanism. The ɛHf(T) of the analyzed ash bed zircons yield values between 0 - +8 averaging at +3.5, clearly indicating a mantle component in the host magmas of the zircons. This initial range of ɛHf(T) is similar to arc-volcanism signatures such as the Quaternary andesitic volcanism in Central Mexico. Petrographic analyses of marls away from the visible tuff layer contain phenocrysts of biotite, alkali feldspar and andesitic rock fragments. The whole rock marl with high concentration of some transition metals (V, Zn, Ni, Pb, Mo) and relatively higher MgO and TiO2 contents indicate contemporaneous arc volcanic activity at the time of marl deposition. XRD of subsurface Eagle Ford bulk marl samples from different depths in 4 cores, show volcanogenic clays, such as montmorillonite, vermiculite, dickite and halloysite

Çalışma Tutumu Ölçeği ve Geçerlik-Güvenirlik Analizleri

OpenAIRE

YAVUZ, Sefer

2015-01-01

Çalışma Tutumu Ölçeği ve Geçerlik-Güvenirlik Analizleri Çalışma üzerine yapılan araştırmaların çoğu çalışma ve bir başka değişken arasındaki ilişkiyi incelemeye yöneliktir. Bu araştırmada ise bireylerin/çalışanların bizzat “çalışma faaliyeti” hakkındaki tutumları ele alınmıştır. Bu amaçla Mistik Yönelimli-Teslimiyetçi Çalışma Tutumu, Kolay Kazanç Yönelimli-Hazcı Çalışma Tutumu ve İş Yönelimli-Çileci Çalışma Tutumu olmak üzere üç boyuttan oluşan bir çalışma tutumu ölçeği geliştirilmiş ve ölçeğ...

The transcriptional regulatory network mediated by banana (Musa acuminata) dehydration-responsive element binding (MaDREB) transcription factors in fruit ripening.

Science.gov (United States)

Kuang, Jian-Fei; Chen, Jian-Ye; Liu, Xun-Cheng; Han, Yan-Chao; Xiao, Yun-Yi; Shan, Wei; Tang, Yang; Wu, Ke-Qiang; He, Jun-Xian; Lu, Wang-Jin

2017-04-01

Fruit ripening is a complex, genetically programmed process involving the action of critical transcription factors (TFs). Despite the established significance of dehydration-responsive element binding (DREB) TFs in plant abiotic stress responses, the involvement of DREBs in fruit ripening is yet to be determined. Here, we identified four genes encoding ripening-regulated DREB TFs in banana (Musa acuminata), MaDREB1, MaDREB2, MaDREB3, and MaDREB4, and demonstrated that they play regulatory roles in fruit ripening. We showed that MaDREB1-MaDREB4 are nucleus-localized, induced by ethylene and encompass transcriptional activation activities. We performed a genome-wide chromatin immunoprecipitation and high-throughput sequencing (ChIP-Seq) experiment for MaDREB2 and identified 697 genomic regions as potential targets of MaDREB2. MaDREB2 binds to hundreds of loci with diverse functions and its binding sites are distributed in the promoter regions proximal to the transcriptional start site (TSS). Most of the MaDREB2-binding targets contain the conserved (A/G)CC(G/C)AC motif and MaDREB2 appears to directly regulate the expression of a number of genes involved in fruit ripening. In combination with transcriptome profiling (RNA sequencing) data, our results indicate that MaDREB2 may serve as both transcriptional activator and repressor during banana fruit ripening. In conclusion, our study suggests a hierarchical regulatory model of fruit ripening in banana and that the MaDREB TFs may act as transcriptional regulators in the regulatory network. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

redMaPPer. I. Algorithm and SDSS DR8 catalog

Energy Technology Data Exchange (ETDEWEB)

Rykoff, E. S.; Rozo, E.; Reddick, R.; Wechsler, R. H. [SLAC National Accelerator Laboratory, Menlo Park, CA 94025 (United States); Busha, M. T. [Institute for Theoretical Physics, University of Zürich, 8057 Zürich (Switzerland); Cunha, C. E. [Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, Palo Alto, CA 94305 (United States); Finoguenov, A. [Department of Physics, University of Helsinki, FI-00014 Helsinki (Finland); Evrard, A.; Koester, B. P. [Physics Department, University of Michigan, Ann Arbor, MI 48109 (United States); Hao, J.; Nord, B. [Center for Particle Astrophysics, Fermi National Accelerator Laboratory, Batavia, IL 60510 (United States); Leauthaud, A. [Kavli Institute for the Physics and Mathematics of the Universe, University of Tokyo, Kashiwa 277-8583 (Japan); Pierre, M.; Sadibekova, T. [Service d' Astrophysique, CEA Saclay, F-91191 Gif sur Yvette Cedex (France); Sheldon, E. S. [Brookhaven National Laboratory, Upton, NY 11973 (United States)

2014-04-20

We describe redMaPPer, a new red sequence cluster finder specifically designed to make optimal use of ongoing and near-future large photometric surveys. The algorithm has multiple attractive features: (1) it can iteratively self-train the red sequence model based on a minimal spectroscopic training sample, an important feature for high-redshift surveys. (2) It can handle complex masks with varying depth. (3) It produces cluster-appropriate random points to enable large-scale structure studies. (4) All clusters are assigned a full redshift probability distribution P(z). (5) Similarly, clusters can have multiple candidate central galaxies, each with corresponding centering probabilities. (6) The algorithm is parallel and numerically efficient: it can run a Dark Energy Survey-like catalog in ∼500 CPU hours. (7) The algorithm exhibits excellent photometric redshift performance, the richness estimates are tightly correlated with external mass proxies, and the completeness and purity of the corresponding catalogs are superb. We apply the redMaPPer algorithm to ∼10, 000 deg{sup 2} of SDSS DR8 data and present the resulting catalog of ∼25,000 clusters over the redshift range z in [0.08, 0.55]. The redMaPPer photometric redshifts are nearly Gaussian, with a scatter σ {sub z} ≈ 0.006 at z ≈ 0.1, increasing to σ {sub z} ≈ 0.02 at z ≈ 0.5 due to increased photometric noise near the survey limit. The median value for |Δz|/(1 + z) for the full sample is 0.006. The incidence of projection effects is low (≤5%). Detailed performance comparisons of the redMaPPer DR8 cluster catalog to X-ray and Sunyaev-Zel'dovich catalogs are presented in a companion paper.

Esophageal pH monitoring

Science.gov (United States)

pH monitoring - esophageal; Esophageal acidity test ... Esophageal pH monitoring is used to check how much stomach acid is entering the esophagus. It also checks how well the acid is cleared downward into the ...

Validity of abundances derived from spaxel spectra of the MaNGA survey

Science.gov (United States)

Pilyugin, L. S.; Grebel, E. K.; Zinchenko, I. A.; Nefedyev, Y. A.; Shulga, V. M.; Wei, H.; Berczik, P. P.

2018-05-01

We measured the emission lines in the spaxel spectra of Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) galaxies in order to determine the abundance distributions therein. It has been suggested that the strength of the low-ionization lines, R2, N2, and S2, may be increased (relative to Balmer lines) in (some) spaxel spectra of the MaNGA survey due to a contribution of the radiation of the diffuse ionized gas. Consequently, the abundances derived from the spaxel spectra through strong-line methods may suffer from large errors. We examined this expectation by comparing the behaviour of the line intensities and the abundances estimated through different calibrations for slit spectra of H II regions in nearby galaxies, for fibre spectra from the Sloan Digital Sky Survey, and for spaxel spectra of the MaNGA survey. We found that the S2 strength is increased significantly in the fibre and spaxel spectra. The mean enhancement changes with metallicity and can be as large as a factor of 2. The mean distortion of R2 and N2 is less than a factor of 1.3. This suggests that Kaufmann et al.'s (2003, MNRAS, 346, 1055) demarcation line between active galactic nuclei and H II regions in the Baldwin, Phillips, & Terlevich (BPT, 1981, PASP, 93, 5) diagram is a useful criterion to reject spectra with significantly distorted strengths of the N2 and R2 lines. We find that the three-dimensional R calibration, which uses the N2 and R2 lines, produces reliable abundances in the MaNGA galaxies. The one-dimensional N2 calibration produces either reliable or wrong abundances depending on whether excitation and N/O abundance ratio in the target region (spaxel) are close to or differ from those parameters in the calibrating points located close to the calibration relation. We then determined abundance distributions within the optical radii in the discs of 47 MaNGA galaxies. The optical radii of the galaxies were estimated from the surface brightness profiles constructed based on the

Geomorphology of Ma'adim Vallis, Mars,and Associated Paleolake Basins

Science.gov (United States)

Irwin, Rossman, P., III; Howard, Alan D.; Maxwell, Ted A.

2004-01-01

Ma'adim Vallis, one of the largest valleys in the Martian highlands, appears to have originated by catastrophic overflow of a large paleola ke located south of the valley heads. Ma'adim Vallis debouched to Gus ev crater, 900 km to the north, the landing site for the Spirit Mars Exploration Rover. Support for the paleolake overflow hypothesis come s from the following characteristics: (I) With a channel width of 3 km at its head, Ma'adim Vallis originates at two (eastern and western) gaps incised into the divide of the approximately 1.1 M km(exp 2) enc losed Eridania head basin, which suggests a lake as the water source. (2) The sinuous course of Ma'adim Vallis is consistent with overland flow controlled by preexisting surface topography, and structural con trol is not evident or required to explain the valley course. (3) The nearly constant approximately 5 km width of the inner channel through crater rim breaches, the anastomosing course of the wide western tri butary, the migration of the inner channel to the outer margins of be nds in the valley's lower reach, a medial sedimentary bar approximate ly 200 m in height, and a step-pool" sequence are consistent with modeled flows of 1-5 x l0 (exp 6) m(exp 3)/s. Peak discharges were likely higher but are poorly constrained by the relict channel geometry. (4 ) Small direct tributary valleys to Ma'adim Vallis have convex-up lon gitudinal profiles, suggesting a hanging relationship to a valley that was incised quickly relative to the timescales of tributary developm ent. (5) The Eridania basin had adequate volume between the initial d ivide and the incised gap elevations to carve Ma'adim Vallis during a single flood. (6) The Eridania basin is composed of many overlapping , highly degraded and deeply buried impact craters. The floor materials of the six largest craters have an unusually high internal relief ( approximately 1 km) and slope (approximately 0.5-1.5 degrees) among d egraded Martian craters, which are usually

Spectroscopic determination of pH

International Nuclear Information System (INIS)

Faanu, A.; Glover, E.T.; Bailey, E.; Rochelle, C.

2009-01-01

A technique of measuring pH at temperature range of 20 - 70 0 C and high pressure conditions of 1 - 200 atmospheres has been developed by relating the ratio of absorbance peaks of indicator solutions (basic and acidic) as a function of pH, using ultraviolet-visible spectrophotometer. The pH values of the buffer solutions measured at 20 0 C and 70 0 C indicated slight temperature dependence, while the pressure had no effect. The pH of the buffer solutions increased with temperature with relative standard deviations in the range 0.4 - 0.5 % at 95 % confidence interval. The possible causes of the temperature dependence were attributed to changes in pH values as the temperature changed. (au)

Evaluation of biodegradation of bionanocomposites of PHB/PP-g-MA/vermiculite

International Nuclear Information System (INIS)

Mesquita, P.J.P. de; Alves, T.S.; Barbosa, R.; Andrade, D. de L.A.C.S.

2014-01-01

In this work, we evaluated the process of biodegradation of PHB bionanocomposites/PP-g-MA/clay. Films were prepared with compositions of 5% PP-g-MA and 3% clay (BIO5); and 2.5% PP-g-MA and 3% clay (BIO2.5). The biodegradation test was conducted according to ASTM G 160-03 for a period of 86 days. The evaluation of biodegradation was performed by optical microscopy (MO), loss of mass, FTIR and XRD. The bionanocomposites presented change of coloration and appearance of fissures. As for loss in mass in the system presented loss of BIO2,5 22.5% and 25.9% BIO5, for 86 days of simulated soil exposure. We also observed by FTIR sharp reduction in intensity of the band corresponding to the C = O groups, indicating that the microbial attack promoted cleavage of the ester group links. By XRD, reduction in the intensity of the peaks and enlargements of the same with increasing exposure time, proving the biodegradation behavior of bionanocomposites. (author)

["StigMa" - Evaluation of a Psychological Therapy Program for Stigma-Management].

Science.gov (United States)

Schenner, Manuela; Kohlbauer, Daniela; Meise, Ullrich; Haller, Christina; Pixner-Huber, Martina; Stürz, Kristina; Günther, Verena

2018-01-01

The project "Stigma Management - StigMa" aims on the evaluation of an adaptive therapy program for patients with psychiatric illness to help them in managing internalized stigma and self-stigmatization. The patients for this pilot-study were recruited in day-hospitals of pro mente tirol . 26 patients participated in 11 group sessions, following 6 modules: "Education", "Activation of Resources", "Social Network", "Self-Esteem", "Social competence in public places" and "My personal stigma management". The control group consisted of 20 patients who did not participate in StigMa. Pre-post-evaluation was done by the Internalized Stigma of Mental Illness-Scale 1. No significant interaction effects could be observed, although in the treatment group, the burden of perceived discrimination was significantly less pronounced after training than before it. The program, however, was evaluated as being extremely positive by the participants. The program StigMa will be adapted in accordance with the suggestions of the participants and reevaluated taking into consideration methodological optimization. © Georg Thieme Verlag KG Stuttgart · New York.

Industrial PhD report: Sustainable Innovation

DEFF Research Database (Denmark)

Olesen, Gitte Gylling Hammershøj

2011-01-01

Erhvervs PhD rapport udarbejdet i tilknytning til Erhvervs PhD kurset der er obligatorisk for Erhvervs PhD studerende. Rapporten omhandler relationer melllem den akademiske verden og industrien i sammenhæng med PhD projektet, betragtet og analyseret gennem teori om bæredygtig innovation....

Reklāma kā sociālā mārketinga elements un tās efektivitāte: CSDD sociālā TV reklāma "Orgānu donori"

OpenAIRE

Priedīte, Unda

2008-01-01

Bakalaura darba tēma ir „ Reklāma kā sociālā mārketinga elements un tās efektivitāte: CSDD sociālā TV reklāma „ Orgānu donori ””. Darbā izvirzītā hipotēze: sociālā TV reklāma „Orgānu donori” kā sociālā mārketinga elements ir bijusi efektīva un tā attaisno vizuālo un tekstuālo risinājumu izvēli, jo spēcīgas emocijas ir viens no efektīvākajiem veidiem, kā sociālo problēmu kontekstā mainīt cilvēku attieksmi un rīcību. Pēc paveiktās teorētiskās informācijas apstrādes un pētījuma rezultātu ana...

On Calibration of pH Meters

Directory of Open Access Journals (Sweden)

Da-Ming Zhu

2005-04-01

Full Text Available The calibration of pH meters including the pH glass electrode, ISE electrodes,buffers, and the general background for calibration are reviewed. Understanding of basicconcepts of pH, pOH, and electrode mechanism is emphasized. New concepts of pH, pOH,as well as critical examination of activity, and activity coefficients are given. Theemergence of new solid state pH electrodes and replacement of the salt bridge with aconducting wire have opened up a new horizon for pH measurements. A pH buffer solutionwith a conducting wire may be used as a stable reference electrode. The misleadingunlimited linear Nernstian slope should be discarded. Calibration curves with 3 nonlinearportions for the entire 0—14 pH range due to the isoelectric point change effect areexplained. The potential measurement with stirring or unstirring and effects by double layer(DL and triple layer (TL will be discussed.

La maîtrise du temps comme enjeu de lutte

OpenAIRE

Bureau, Marie-Christine; Corsani, Antonella

2012-01-01

Le conflit social autour de la réforme du régime d'assurance chômage des intermittents du spectacle a été marqué par son intensité et par sa durée. La thèse défendue ici est que la maîtrise du temps constitue l’un des enjeux majeurs de ce conflit. L'affrontement sur le terrain économique de la régulation de l'emploi et de l'industrie culturelle s'est doublé de l'affrontement sur le temps. La question du temps ne se limite pas à la régulation du temps de travail, elle concerne la maîtrise du t...

Regulation of Banana Phytoene Synthase (MaPSY) Expression, Characterization and Their Modulation under Various Abiotic Stress Conditions

Science.gov (United States)

Kaur, Navneet; Pandey, Ashutosh; Shivani; Kumar, Prateek; Pandey, Pankaj; Kesarwani, Atul K.; Mantri, Shrikant S.; Awasthi, Praveen; Tiwari, Siddharth

2017-01-01

Phytoene synthase (PSY) is a key regulatory enzyme of carotenoid biosynthesis pathway in plants. The present study examines the role of PSY in carotenogenesis and stress management in banana. Germplasm screening of 10 Indian cultivars showed that Nendran (3011.94 μg/100 g dry weight) and Rasthali (105.35 μg/100 g dry weight) contained the highest and lowest amounts of β-carotene, respectively in ripe fruit-pulp. Nendran ripe pulp also showed significantly higher antioxidant activity as compared to Rasthali. Meta-analysis of three banana PSY genes (MaPSY1, MaPSY2, and MaPSY3) was performed to identify their structural features, subcellular, and chromosomal localization in banana genome. The distinct expression patterns of MaPSY1, MaPSY2, and MaPSY3 genes were observed in various tissues, and fruit developmental stages of these two contrasting cultivars, suggesting differential regulation of the banana PSY genes. A positive correlation was observed between the expression of MaPSY1 and β-carotene accumulation in the ripe fruit-peel and pulp of Nendran. The presence of stress responsive cis-regulatory motifs in promoter region of MaPSY genes were correlated with the expression pattern during various stress (abscisic acid, methyl jasmonate, salicylic acid and dark) treatments. The positive modulation of MaPSY1 noticed under abiotic stresses suggested its role in plant physiological functions and defense response. The amino acid sequence analysis of the PSY proteins in contrasting cultivars revealed that all PSY comprises conserved domains related to enzyme activity. Bacterial complementation assay has validated the functional activity of six PSY proteins and among them PSY1 of Nendran (Nen-PSY1) gave the highest activity. These data provide new insights into the regulation of PSY expression in banana by developmental and stress related signals that can be explored in the banana improvement programs. PMID:28421096

Obama vu de ma banlieue.

Directory of Open Access Journals (Sweden)

Olga Stanislawska

2008-12-01

Full Text Available Une petite brocante est organisée tous les jeudis sur une place proche de la Basilique de Saint-Denis. On y vend des livres, des bibelots, des bijoux fantaisies et des masques africains. L’un des vendeurs a visiblement décidé de bénéficier de l’effet Obama. J’ai pris la photo de ma fenêtre, située au dessus de ce marché. J’ai adoré ce stand, mais ce n’est qu’une fois sur l’écran de mon ordinateur que j’ai vu les petites images Banania... ! Si j’avais su, je serais ...

Conceptual Framework: Development of Interactive Reading Malay Language Learning System (I-ReaMaLLS

Directory of Open Access Journals (Sweden)

Ismail Nurulisma

2018-01-01

Full Text Available Reading is very important to access knowledge. Reading skills starts during preschool level no matter of the types of languages. At present, there are many preschool children who are still unable to recognize letters or even words. This leads to the difficulties in reading. Therefore, there is a need of intervention in reading to overcome such problems. Thus, technologies were adapted in enhancing learning skills, especially in learning to read among the preschool children. Phonological is one of the factors to be considered to ensure a smooth of transition into reading. Phonological concept enables the first learner to easily learn reading such to learn reading Malay language. The medium of learning to read Malay language can be assisted via the supportive of multimedia technology to enhance the preschool children learning. Thus, an interactive system is proposed via a development of interactive reading Malay language learning system, which is called as I-ReaMaLLS. As a part of the development of I-ReaMaLLS, this paper focus on the development of conceptual framework in developing interactive reading Malay language learning system (I-ReaMaLLS. I-ReaMaLLS is voice based system that facilitates the preschool learner in learning reading Malay language. The conceptual framework of developing I-ReaMaLLS is conceptualized based on the initial study conducted via methods of literature review and observation with the preschool children, aged 5 – 6 years. As the result of the initial study, research objectives have been affirmed that finally contributes to the design of conceptual framework for the development of I-ReaMaLLS.

Hubungan Religiusitas dan Kebahagiaan dengan Motivasi Belajar Santri di MA Mu’allimin Yogyakarta

Directory of Open Access Journals (Sweden)

Rania Melani

2016-12-01

Full Text Available This study motivated their learning motivation often decreased due to; They have to follow different school rules, they just hang out with their male friends, they will be sanctioned if they make mistakes, lack the motivation to perform best because of the homogeneity of the students in school, the lack of time to get along with the family and you. This research aims to know relation of religiosity and happiness with learning motivation at santri in MA mu'allimin Yogyakarta, religiosity relationship with motivation to learn at santri at MA Mu'allimin Yogyakarta, happiness relationship with motivation to learn at santri at MA Mu'allimin Yogyakarta. The method used is quantitative research method. The subject of this research is santri MA Mu'allimin Yogyakarta academic year 2014-2015. Data collection techniques are with the scale of learning motivation, religiosity and happiness. The method of analysis used in this study is multiple linear regression, using the help of SPSS 19.0 for windows. The results of this study: the relationship of religiosity and happiness to the motivation of learning, a significant relationship between religiosity with learning motivation, and the relationship between happiness with learning motivation.

DVD-d. Shrek Kolmas; Ma olen legend / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2008-01-01

Lühiarvustused USA 2007.a. filmidele : animafilm "Shrek Kolmas" ("Shrek the Third", režissöörid Chris Miller, Raman Hui) ja ulmefilm "Ma olen legend" ("I Am Legend"; režissöör Francis Lawrence)

Comparative study of the wear resistance of Al₂O₃-coated MA956 superalloy

Directory of Open Access Journals (Sweden)

Canahua Loza, Hugo

2000-10-01

Full Text Available Preoxidation of the MA956 superalloy, proposed as a prosthetic biomaterial, generates a compact and inert a-alumina surface layer. The aim of this study is to assess the wear resistance provided by this alumina layer on the MA956 alloy in comparison with the same coated alloy and versus high density polyethylene. Comparative wear tests were carried out in both dry and wet conditions using the couples MA956/MA956, MA956/UHMWPE (ultra high molecular weight polyethylene and 316LVM/UHMWPE. The results corresponding to the couples MA956/MA956, with and without alumina layer, show that the load has more significant effect than the rotation speed on the weight loss and on the roughness. On the other hand the alumina surface layer provides a clear wear protection. The weight losses of the MA956 specimen in this couple are ten times lower when testing under wet conditions than under dry conditions. The MA956/UHMWPE couple behaves much better than the 316LVM/UHMWPE, as it presents the lowest values of friction coefíicient and weight losses of the MA956 specimen. These are only detectable after 70,000 cycles under a 70 MPa contact pressure. This couple offers the best guarantee of a prolonged service life for articulated parts in a prosthesis.

La superaleación MA956, que se ha propuesto como biomaterial para prótesis osteoarticulares genera, mediante un adecuado tratamiento de preoxidación, una capa superficial, compacta e inerte, de alúmina alfa. El objetivo del presente trabajo es el estudio de la resistencia al desgaste de esta capa de alúmina, cuando se encuentra en contacto con la propia aleación recubierta y con polietileno de alta densidad. Se realizaron ensayos comparativos de desgaste, tanto en seco como en húmedo, con los pares MA956/MA956, MA956/UHMWPE (polietileno de muy elevado peso molecular y 316LVM/UHMWPE. Los resultados obtenidos con el par MA956/MA956, con y sin capa de alúmina, indican que la carga es el factor de mayor

Study of MA Effect on Yield Strength and Ductility of X80 Linepipe Steels Weld

Science.gov (United States)

Huda, Nazmul; Lazor, Robert; Gerlich, Adrian P.

2017-09-01

Multipass GMAW (Gas Metal Arc Welding) welding was used to join X80 linepipe materials using two weld metals of slightly different compositions. Welding wires with diameters of 0.984 and 0.909 mm were used while applying the same heat input in each pass. The slight difference in the wire diameters resulted in different HAZ microstructures. The microstructures in the doubly reheated HAZ of both welds were found to contain bainite-ferrite. However, etching also revealed a difference in martensite-austenite (MA) fraction in these reheated zones. The MA exhibited twice the hardness of ferrite when measured by nanoindentation. Tensile testing from the reheated zone of both welds revealed a difference in yield strength, tensile strength and elongation of the transverse weld specimens. In the reheated zone of weld A, (produced with a 0.984 mm wire) a higher fraction of MA was observed, which resulted in higher strength but lower elongation compared to weld B. The ductility of weld A was found severely impaired (to nearly half of weld B) due to formation of closely spaced voids around the MA, along with debonding of MA from the matrix, which occurs just above the yield stress.

Maíz: Alimento fundamental en las tradiciones y costumbres mexicanas

OpenAIRE

José de Jesús Cuevas Mejía

2014-01-01

El siguiente trabajo busca recalcar la importancia del maíz para el pueblo mexicano, que con el paso de los años ha logrado mantener su identidad no en vano por la fuerza y majestuosidad de sus tradiciones y costumbres. Es cierto que hoy en día es la base de la alimentación de muchas familias a lo largo del territorio de México, en cada hogar a la hora del almuerzo, la comida e incluso la merienda, el maíz está presente en una gran variedad de formas, texturas y colores. Esto nos hace pensar ...

Intracellular pH and 42.00 C heat response of CHO cells cultured at pH 6.6

International Nuclear Information System (INIS)

Cook, J.A.; Fox, M.H.

1987-01-01

The authors previously reported that cells under chronic low pH (6.6) conditions have altered thermotolerance. They further characterized both the doubling time (t/sub d/) and the internal pH (pH/sub 1/) of CHO cells continuously cultured at pH 6.6 for times greater than one year. The following differences were noted: 1) A t/sub d/ of 16 hr compared to a t/sub d/ of 12 hr for cells at normal pH (7.3) and a t/sub d/ of 25 hr for the acute low pH cells (pH = 6.6; incubation time = 4 hr). 2) A pH/sub i/ 0.1-0.15 pH units > normal cells and 0.3 pH units > acute low pH cells. 3) Survival at 42.0 0 C which differed from both normal and acute low pH cells. The chronic culture was still quite sensitive to 42.0 0 C treatments during the first 5 hr, but developed tolerance at a higher level than cells under acute low pH conditions. The pH/sub i/ of the chronic culture responded to 42.0 0 C heating in a manner similar to that for acute low pH cells. Whether this culture represents a normal response to long term low pH exposure, or was the response of a mutant population is at the present unknown

The Launch of the MA-6, Friendship 7

Science.gov (United States)

1962-01-01

The launch of the MA-6, Friendship 7, on February 20, 1962. Boosted by the Mercury-Atlas vehicle, a modified Atlas Intercontinental Ballistic Missile (ICBM), Friendship 7 was the first U.S. marned orbital flight and carried Astronaut John H. Glenn into orbit. Astronaut Glenn became the first American to orbit the Earth.

Analysis of MaACS2, a stress-inducible ACC Synthase Gene in Musa acuminata AAA Group Cultivar Pisang Ambon

Directory of Open Access Journals (Sweden)

Resnanti Utami Handayani

2014-07-01

Full Text Available Ethylene has an important function in plant growth and development. Ethylene production generally increases in response to pathogen attacks and other environmental stress conditions. The synthesis of this phytohormone is regulated by two enzymes, ACC synthase (ACS and ACC oxidase (ACO. ACC synthase is encoded by a multigene that regulates the production of ACC, after which this precursor is converted into ethylene by ACO. Pisang Ambon (Musa sp. AAA group, a banana cultivar originating from Indonesia, has nine ACS genes (MaACS 1-9 and one ACO gene (MaACO. One of the banana ACS genes, MaACS2, is stress-inducible. In this research, we have investigated the expression profile of MaACS2 in the roots and leaf tissues of infected tissue culture plants. Quantification of gene expression was analyzed using Real-Time PCR (qPCR using Ma18srRNA and MaGAPDH as reference genes. The results showed nine-to ten fold higher MaACS2 expression levels in the infected roots tissues compared to the uninfected roots tissues. However, MaACS2 expression in the leaves was only detected in infected tissue.

MA-23-6000: underwater bilateral servo master slave manipulator

International Nuclear Information System (INIS)

Vertut, Jean

The different types of manipulators, recent data on their dexterity and the underwater work possible with servo master slave manipulators are reviewed. The general specifications of the manipulator MA 23-6000 designed for the machine ERIC II are given [fr

A Multi-Approach Evaluation System (MA-ES) of Organic Rankine Cycles (ORC) used in waste heat utilization

International Nuclear Information System (INIS)

Shu, Gequn; Yu, Guopeng; Tian, Hua; Wei, Haiqiao; Liang, Xingyu

2014-01-01

Highlights: • The MA-ES provides comprehensive valuations on ORC used for waste heat utilization. • The MA-ES covers energetic, exergetic and economic evaluations of typical ORCs. • The MA-ES is a general assessing method without restriction to specific ORC condition. • Two ORC cases of ICE waste-heat-recovery are exemplified applying the MA-ES. - Abstract: A Multi-Approach Evaluation System (MA-ES) is established in this paper providing comprehensive evaluations on Organic Rankine Cycles (ORC) used for waste heat utilization. The MA-ES covers three main aspects of typical ORC performance: basic evaluations of energy distribution and system efficiency based on the 1st law of thermodynamics; evaluations of exergy distribution and exergy efficiency based on the 2nd law of thermodynamics; economic evaluations based on calculations of equipment capacity, investment and cost recovery. The MA-ES is reasonably organized aiming at providing a general method of ORC performance assessment, without restrictions to system configurations, operation modes, applications, working fluid types, equipment conditions, process parameters and so on. Two ORC cases of internal combustion engines’ (ICEs) waste-heat-recovery are exemplified to illustrate the applications of the evaluation system. The results clearly revealed the performance comparisons among ORC configurations and working fluids referred. The comparisons will provide credible guidance for ORC design, equipment selection and system construction

Electrolyte Engineering Toward Efficient Hydrogen Production Electrocatalysis with Oxygen-crossover Regulation under Densely Buffered Near-neutral pH Conditions

KAUST Repository

Shinagawa, Tatsuya; Takanabe, Kazuhiro

2015-01-01

This study tackles the core issues associated with near-neutral pH water splitting, particularly regarding electrolyte engineering in the electrocatalysis and product cross-over. We demonstrate that solute engineering has a major impact on water splitting electrocatalysis because the diffusion component, often not well integrated into performance descriptions, largely determines the overall performance. The hydrogen evolution reaction (HER) was investigated on Pt, Ni and NiMo catalysts in various concentrations of cations (Li+, K+, Na+) and anions (H2PO4−, HPO42−, PO43− and HCO3−) to describe its performance by quantifying kinetics, diffusion and solution resistance. In fact, the choice of electrolyte in terms of its identity and activity drastically altered the HER rate and oxygen mass-transport flux at near-neutral pH. Electrolyte properties (activity coefficient, kinematic viscosity and diffusion coefficient) accurately described the diffusion contribution, which can be easily isolated when a highly active Pt catalyst was used for the HER. By analyzing these properties, we maximized the HER rate on the Pt by tuning the solute concentration (typically 1.5 – 2.0 M). Moreover, the kinematic viscosity and oxygen solubility in such densely buffered conditions governed the oxygen mass-transport flux in the electrolyte, which in turn tuned the cross-over flux. At near-neutral pH, as high as 90 % selectivity toward the HER was achieved even under an oxygen saturated condition, where only a 40 mV overpotential was needed to achieve 10 mA cm−2 for the HER. This information can be regarded as an important milestone for achieving a highly efficient water splitting system at near-neutral pH.

Electrolyte Engineering Toward Efficient Hydrogen Production Electrocatalysis with Oxygen-crossover Regulation under Densely Buffered Near-neutral pH Conditions

KAUST Repository

Shinagawa, Tatsuya

2015-12-30

This study tackles the core issues associated with near-neutral pH water splitting, particularly regarding electrolyte engineering in the electrocatalysis and product cross-over. We demonstrate that solute engineering has a major impact on water splitting electrocatalysis because the diffusion component, often not well integrated into performance descriptions, largely determines the overall performance. The hydrogen evolution reaction (HER) was investigated on Pt, Ni and NiMo catalysts in various concentrations of cations (Li+, K+, Na+) and anions (H2PO4−, HPO42−, PO43− and HCO3−) to describe its performance by quantifying kinetics, diffusion and solution resistance. In fact, the choice of electrolyte in terms of its identity and activity drastically altered the HER rate and oxygen mass-transport flux at near-neutral pH. Electrolyte properties (activity coefficient, kinematic viscosity and diffusion coefficient) accurately described the diffusion contribution, which can be easily isolated when a highly active Pt catalyst was used for the HER. By analyzing these properties, we maximized the HER rate on the Pt by tuning the solute concentration (typically 1.5 – 2.0 M). Moreover, the kinematic viscosity and oxygen solubility in such densely buffered conditions governed the oxygen mass-transport flux in the electrolyte, which in turn tuned the cross-over flux. At near-neutral pH, as high as 90 % selectivity toward the HER was achieved even under an oxygen saturated condition, where only a 40 mV overpotential was needed to achieve 10 mA cm−2 for the HER. This information can be regarded as an important milestone for achieving a highly efficient water splitting system at near-neutral pH.

Constant pH Accelerated Molecular Dynamics Investigation of the pH Regulation Mechanism of Dinoflagellate Luciferase.

Science.gov (United States)

Donnan, Patrick H; Ngo, Phong D; Mansoorabadi, Steven O

2018-01-23

The bioluminescence reaction in dinoflagellates involves the oxidation of an open-chain tetrapyrrole by the enzyme dinoflagellate luciferase (LCF). The activity of LCF is tightly regulated by pH, where the enzyme is essentially inactive at pH ∼8 and optimally active at pH ∼6. Little is known about the mechanism of LCF or the structure of the active form of the enzyme, although it has been proposed that several intramolecularly conserved histidine residues in the N-terminal region are important for the pH regulation mechanism. Here, constant pH accelerated molecular dynamics was employed to gain insight into the conformational activation of LCF induced by acidification.

46 CFR 308.524 - Application for cancellation of Open Cargo Policy, Form MA-304.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Application for cancellation of Open Cargo Policy, Form... § 308.524 Application for cancellation of Open Cargo Policy, Form MA-304. The standard form of application for cancellation of an Open Cargo Policy Form MA-304 may be obtained from the American War Risk...

PH og modernismen

DEFF Research Database (Denmark)

Ahnfeldt-Mollerup, Merete

2012-01-01

Artiklen kaster et kritisk blik på Poul Henningsens samfundsanalyse og dennes sammenhæng med hans design. PH ses i en bredere national og international sammenhæng. Diskussion af designmetoder, æstetik og Bauhaus.......Artiklen kaster et kritisk blik på Poul Henningsens samfundsanalyse og dennes sammenhæng med hans design. PH ses i en bredere national og international sammenhæng. Diskussion af designmetoder, æstetik og Bauhaus....

MoMaS reactive transport benchmark using PFLOTRAN

Science.gov (United States)

Park, H.

2017-12-01

MoMaS benchmark was developed to enhance numerical simulation capability for reactive transport modeling in porous media. The benchmark was published in late September of 2009; it is not taken from a real chemical system, but realistic and numerically challenging tests. PFLOTRAN is a state-of-art massively parallel subsurface flow and reactive transport code that is being used in multiple nuclear waste repository projects at Sandia National Laboratories including Waste Isolation Pilot Plant and Used Fuel Disposition. MoMaS benchmark has three independent tests with easy, medium, and hard chemical complexity. This paper demonstrates how PFLOTRAN is applied to this benchmark exercise and shows results of the easy benchmark test case which includes mixing of aqueous components and surface complexation. Surface complexations consist of monodentate and bidentate reactions which introduces difficulty in defining selectivity coefficient if the reaction applies to a bulk reference volume. The selectivity coefficient becomes porosity dependent for bidentate reaction in heterogeneous porous media. The benchmark is solved by PFLOTRAN with minimal modification to address the issue and unit conversions were made properly to suit PFLOTRAN.

MaROS Strategic Relay Planning and Coordination Interfaces

Science.gov (United States)

Allard, Daniel A.

2010-01-01

The Mars Relay Operations Service (MaROS) is designed to provide planning and analysis tools in support of ongoing Mars Network relay operations. Strategic relay planning requires coordination between lander and orbiter mission ground data system (GDS) teams to schedule and execute relay communications passes. MaROS centralizes this process, correlating all data relevant to relay coordination to provide a cohesive picture of the relay state. Service users interact with the system through thin-layer command line and web user interface client applications. Users provide and utilize data such as lander view periods of orbiters, Deep Space Network (DSN) antenna tracks, and reports of relay pass performance. Users upload and download relevant relay data via formally defined and documented file structures including some described in Extensible Markup Language (XML). Clients interface with the system via an http-based Representational State Transfer (ReST) pattern using Javascript Object Notation (JSON) formats. This paper will provide a general overview of the service architecture and detail the software interfaces and considerations for interface design.

A "embolada" em Macunaíma

Directory of Open Access Journals (Sweden)

Raimunda B. Batista

2004-12-01

Full Text Available Os intelectuais do modernismo brasileiro tiveram como preocupação a redefinição da cultura brasileira tomando como ponto de partida a cultura popular e o folclore brasileiros. Em Macunaíma, Mário de Andrade aproveita os mais variados elementos da cultura popular, dando-lhes uma configuração erudita. Entre esses elementos destacamos o aproveitamento da embolada que, enquanto modo de cantar, possui uma forte estrutura poética, podendo ser aproveitada na prosa de ficção, conservando o seu ritmo e forma.

Effect of Fast Neutron to MA/PU Burning/Transmutation Characteristic Using a Fast Reactor

International Nuclear Information System (INIS)

Marsodi; Lasman, As Natio; Kimamoto, A.; Marsongkohadi; Zaki, S.

2003-01-01

MA/Pu burning/transmutation has been studied and evaluated using fast neutrons. Generally, neutron density at this fast burner reactor and transmutation has spectrum energy level around 0.2 MeV with wide enough variation, i.e. from low neutron spectrum to its peak is 0.2 MeV. This neutron spectrum energy level depends on the kind of cooler material or fuel used. Neutron spectrum higher than fast power reactor neutron spectrum is found by means of changing oxide fuel by metallic fuel and changing natrium cooler material by metallic or gas cooler material. This evaluation is conducted by various variations in accordance with the kind of fuel or cooler, MA/Pu fractions and fuel comparison fraction with respect to its cooler in order to get better neutron usage and MA/Pu burning speed. Reactor calculation evaluation in this paper was conducted with 26-group nuclear data cross section energy spectrum. The main purpose of the discussion is to know the effect of fast neutrons to burning/transmutation MA/Pu using fast neutrons

First results from quality assurance testing of MaPMTs for the LHCb RICH upgrade

Science.gov (United States)

Gambetta, S.; LHCb RICH Collaboration

2017-12-01

In 2019 the LHCb RICH detector will be upgraded to increase the read out rate from 1 MHz to 40 MHz. As a consequence, the current Hybrid Photon Detectors will have to be replaced. Multi-anode Photomultiplier Tubes (MaPMTs) from Hamamatsu with 64-channels will be used: the 1-in. R13742 and the 2-in. R13743 MaPMTs (custom modifications of the MaPMTs R11625 and R12699). Quality assurance testing of these MaPMTs using custom-developed readout electronics has started. We present the design and realisation of the test facilities to ensure consistency in testing and validation. A total of 3100 units of the R13742 and 450 units of the R13743 will be tested requiring high efficiency and reliability from the test stations. We report on the test programme and protocols, characterising the units and assuring compliance with specifications. First results of testing and detector characterisation will be presented, based on the pre-series production, comprising 54 units of R13742 and 20 units of R13743.

Radiation hardening and irradiation testing of in-cell electronics for MA23/APM

International Nuclear Information System (INIS)

Friant, A.

1988-09-01

We relate briefly the radiation hardening method used to guarantee a gamma resistance of 10 Mrad for the whole electronic equipment associated with the slave arm of MA23 M servomanipulator which will be set up in cell 404 in Marcoule (APM). We describe the radiation testing of electronic devices and of the various subsystems designed by the D. LETI groups involved in the MA23/APM project

Advanced Query and Data Mining Capabilities for MaROS

Science.gov (United States)

Wang, Paul; Wallick, Michael N.; Allard, Daniel A.; Gladden, Roy E.; Hy, Franklin H.

2013-01-01

The Mars Relay Operational Service (MaROS) comprises a number of tools to coordinate, plan, and visualize various aspects of the Mars Relay network. These levels include a Web-based user interface, a back-end "ReSTlet" built in Java, and databases that store the data as it is received from the network. As part of MaROS, the innovators have developed and implemented a feature set that operates on several levels of the software architecture. This new feature is an advanced querying capability through either the Web-based user interface, or through a back-end REST interface to access all of the data gathered from the network. This software is not meant to replace the REST interface, but to augment and expand the range of available data. The current REST interface provides specific data that is used by the MaROS Web application to display and visualize the information; however, the returned information from the REST interface has typically been pre-processed to return only a subset of the entire information within the repository, particularly only the information that is of interest to the GUI (graphical user interface). The new, advanced query and data mining capabilities allow users to retrieve the raw data and/or to perform their own data processing. The query language used to access the repository is a restricted subset of the structured query language (SQL) that can be built safely from the Web user interface, or entered as freeform SQL by a user. The results are returned in a CSV (Comma Separated Values) format for easy exporting to third party tools and applications that can be used for data mining or user-defined visualization and interpretation. This is the first time that a service is capable of providing access to all cross-project relay data from a single Web resource. Because MaROS contains the data for a variety of missions from the Mars network, which span both NASA and ESA, the software also establishes an access control list (ACL) on each data record

M&A flows and the foreign exchange markets:practical experiences

Directory of Open Access Journals (Sweden)

Martijn A. Schrijvers

2002-03-01

Full Text Available The large cross-border Merger and Acquisition flows of the last three years were seen by financial markets as one of the factors behind movements in exchange rates. However, the extent to which an M&A-transaction actually leads to a foreignexchange transaction is dependent on the financing and transaction techniques used and is difficult to measure. In this article, we analyse which considerations underlie the decisions of corporate Treasurers regarding the financing of take-overs and the techniques to be used by forex transactions. We investigate the effect Treasurers believe M&A transactions have on exchange rates and examine whether different techniques make for different effects. The information was obtained through interviews with Treasurers of multinationals conducting large-scale M&A activities.

Micro Electrochemical pH Sensor Applicable for Real-Time Ratiometric Monitoring of pH Values in Rat Brains.

Science.gov (United States)

Zhou, Jie; Zhang, Limin; Tian, Yang

2016-02-16

To develop in vivo monitoring meter for pH measurements is still the bottleneck for understanding the role of pH plays in the brain diseases. In this work, a selective and sensitive electrochemical pH meter was developed for real-time ratiometric monitoring of pH in different regions of rat brains upon ischemia. First, 1,2-naphthoquinone (1,2-NQ) was employed and optimized as a selective pH recognition element to establish a 2H(+)/2e(-) approach over a wide range of pH from 5.8 to 8.0. The pH meter demonstrated remarkable selectivity toward pH detection against metal ions, amino acids, reactive oxygen species, and other biological species in the brain. Meanwhile, an inner reference, 6-(ferrocenyl)hexanethiol (FcHT), was selected as a built-in correction to avoid the environmental effect through coimmobilization with 1,2-NQ. In addition, three-dimensional gold nanoleaves were electrodeposited onto the electrode surface to amplify the signal by ∼4.0-fold and the measurement was achieved down to 0.07 pH. Finally, combined with the microelectrode technique, the microelectrochemical pH meter was directly implanted into brain regions including the striatum, hippocampus, and cortex and successfully applied in real-time monitoring of pH values in these regions of brain followed by global cerebral ischemia. The results demonstrated that pH values were estimated to 7.21 ± 0.05, 7.13 ± 0.09, and 7.27 ± 0.06 in the striatum, hippocampus, and cortex in the rat brains, respectively, in normal conditions. However, pH decreased to 6.75 ± 0.07 and 6.52 ± 0.03 in the striatum and hippocampus, upon global cerebral ischemia, while a negligible pH change was obtained in the cortex.

42 CFR 422.74 - Disenrollment by the MA organization.

Science.gov (United States)

2010-10-01

... providing reasonable accommodations, as determined by CMS, for individuals with mental or cognitive conditions, including mental illness and developmental disabilities. In addition, the MA organization must... timeframes specified in § 422.506(a)(2). (e) Consequences of disenrollment—(1) Disenrollment for non-payment...

Ma ma (2015: un reflejo de la mujer española con cáncer de mama

Directory of Open Access Journals (Sweden)

Clara Peralta?Nueno et al.

2017-03-01

Full Text Available Ma ma (2015 es una película de drama española dirigida por Julio Medem y producida por Morena Films. Esta película narra la historia de la vida de Magda cuyo personaje es interpretado por Penélope Cruz. Tras serle diagnosticado un cáncer de mama, Magda, una maestra en paro, no sabrá cómo actuar ni de qué manera cambiará esta enfermedad su vida, pero poco a poco sacará a la superficie toda su energía vital. El cáncer de mama representa el tipo de cáncer más frecuente en la mujer. Aunque la mayoría de los factores de riesgo identificados pueden ser modificables, los sistemas de salud se concentran en actividades que permiten fortalecer la prevención primaria y actividades de prevención secundaria y terciaria. La detección temprana y el tratamiento adecuado son indispensables para luchar contra esta enfermedad. El proceso emocional generado por la presencia de cáncer, conlleva un mecanismo de reconstitución psíquico que permite a la paciente conformar una respuesta a los desafíos orgánicos, cognitivos, sociales y emocionales a los cuales se ve enfrentada. Dicho proceso es favorecido entre otros factores por contar con una red de apoyo socio?familiar sólida.

Effect of modified atmosphere packaging on the course of physical and chemical changes in chilled muscle tissue of silver carp (Hypophthalmichthys molitrix, V.).

Science.gov (United States)

Jezek, F; Buchtová, H

2012-01-01

The effect of two types of modified atmosphere (MA1: 69% N2, 25% CO2, 5% O2, 1% CO; MA2: 70% N2, 30% CO2) on changes in physical and chemical parameters (pH, a(w)--water activity, TVBN - total volatile basic nitrogen, TMA - trimethylamine, FFA - free fatty acids, PV - peroxide value, TBA--thiobarbituric acid) in muscle tissues of the silver carp was monitored in the study. The samples were stored at temperatures +2 +/- 2 degrees C for 18 days. Changes in gas volumes (CO2 and O2) in MAs were also monitored. CO2 levels increased in MA1 but decreased in MA2. At the end of 18 days of storage, a significantly (P MA2 where water activity values showed considerable fluctuation. Variations in pH values in the two types of MA showed similar trends. Sample pH gradually decreased until day 9 of storage. On day 11, muscle tissue pH increased markedly and then began to decrease again. The overall decrease in pH values was more profound in samples packaged under MA1. TVBN and TMA levels in samples packaged under the two types of MAs remained almost identical until day 9 of the experiment. Later, however, significantly (P MA2. Faster rates of oxidation (P MA2 were observed on days 14 and 18 of the experiment, respectively. From the course of proteolytic and oxidative changes point of view, the more appropriate combination of gases for silver carp storage seems to be the mixture of 70% N2 and 30% CO2 (MA2), which allows for muscle storage of up to 9 days. We recommend TVBN as a suitable indicator of freshness, and TBA assay as a suitable indicator of the extent of oxidative processes.

46 CFR 308.523 - Application for revision of Open Cargo Policy, Form MA-303.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Application for revision of Open Cargo Policy, Form MA... Application for revision of Open Cargo Policy, Form MA-303. An application for the revision of an Open Cargo Policy shall be filed in duplicate with the Underwriting Agent on a form which may be obtained from the...

The International Diversification of Banks and the Value of their Cross-Border M&A Advice

NARCIS (Netherlands)

de Jong, A.; Ongena, S.; van der Poel, M.

2010-01-01

This paper investigates the effects of international diversification of banks on the value of their M&A advice. We study bidder returns to 1,253 cross-border M&A announcements. We find that acquirers engaging a more internationally diversified financial advisor generate lower excess returns.

Optimum pH and pH Stability of Crude Polyphenol Oxidase (PPO ...

African Journals Online (AJOL)

The effect of pH on the activity and stability of crude polyphenol oxidase (PPO) extracted from garden egg (Solanum aethiopicum), pawpaw (Carica papaya), pumpkin ... Optimum pH values were found to be 6.0,6.5,6.0, 4.5 and 4.0/or 8.0 for the enzyme extracted from Solanum aethiopicum, Carica papaya, Cucurbita pepo, ...

M&A New Rules May Trigger Merger Wave

Institute of Scientific and Technical Information of China (English)

HUBERT TSE

2006-01-01

@@ The Chinese government issued a series of new M&A and takeover rules in July and August 2006 to further regulate and facilitate foreign investors' acquisition activities in China.The new rules are aimed at offering more flexibility, reducing costs and increasing takeover efficiencies for foreign-funded M&As in the world's fastest-growing major economy.

Low-dose respiratory-gated PET/CT: based on 30 mA tube current

International Nuclear Information System (INIS)

Wu Ping; Li Sijin; Zhang Yanlan; Hao Xinzhong; Qin Zhixing; Yan Min; Cheng Pengliang; Wu Zhifang

2013-01-01

Objective: To establish a low-dose but image-comparable respiratory-gated PET/CT (RG PET/CT) protocol based on 30 mA tube current plus other improved scanning parameters, such as the tube current, the number of respiratory phase and length of breathing cycle. Methods: Twenty-six patients with 18 F-FDG-intaking lung nodules underwent one-bed standard-dose PET/CT (120 mA, 2 min/bed) and low dose RG PET/CT (30 mA, 6 respiratory phases, 1 min/phase). The radiation dose and image quality were analyzed subsequently with signal to noise ratio (SNR) for PET and the homogeneity, noise level for CT in the water phantom respectively. Otherwise the CT images were both visual evaluated by two experienced doctors. In addition, different respiratory cycle was simulated to observe its relation with radiation dose. Results: The effective dose of low-dose RG PET/CT was 4.88∼7.69 mSv [mean (5.68±0.83) mSv]. The PET SNR showed no significance between groups. The homogeneity of 30 mA is good (< 5 HU), although noise level was high, the visual character like lobulation, speculation of lung nodule was superior in some respiratory phases. The radiation dose was positively correlated with respiratory cycle. Conclusions: The performance of low-dose RG PET/CT was comparable to those of standard-dose PET/CT based on a protocol with 30 mA tube current, 6 respiratory phases and breathing state of eupnoea. It produced a much lower radiation exposure and the image quality was enough for clinical use such as delineation of tumor active target, characterization and staging of lung nodules, etc. (authors)

Label-Free Carbon-Dots-Based Ratiometric Fluorescence pH Nanoprobes for Intracellular pH Sensing.

Science.gov (United States)

Shangguan, Jingfang; He, Dinggeng; He, Xiaoxiao; Wang, Kemin; Xu, Fengzhou; Liu, Jinquan; Tang, Jinlu; Yang, Xue; Huang, Jin

2016-08-02

Measuring pH in living cells is of great importance for better understanding cellular functions as well as providing pivotal assistance for early diagnosis of diseases. In this work, we report the first use of a novel kind of label-free carbon dots for intracellular ratiometric fluorescence pH sensing. By simple one-pot hydrothermal treatment of citric acid and basic fuchsin, the carbon dots showing dual emission bands at 475 and 545 nm under single-wavelength excitation were synthesized. It is demonstrated that the fluorescence intensities of the as-synthesized carbon dots at the two emissions are pH-sensitive simultaneously. The intensity ratio (I475 nm/I545 nm) is linear against pH values from 5.2 to 8.8 in buffer solution, affording the capability as ratiometric probes for intracellular pH sensing. It also displays that the carbon dots show excellent reversibility and photostability in pH measurements. With this nanoprobe, quantitative fluorescence imaging using the ratio of two emissions (I475 nm/I545 nm) for the detection of intracellular pH were successfully applied in HeLa cells. In contrast to most of the reported nanomaterials-based ratiometric pH sensors which rely on the attachment of additional dyes, these carbon-dots-based ratiometric probes are low in toxicity, easy to synthesize, and free from labels.

Estrategias de reproducción social de los productores de maíz de Tlaxcala

Directory of Open Access Journals (Sweden)

Miguel Ángel Damián Huato

2009-01-01

Full Text Available Se analizan las múltiples estrategias de reproducción social de los productores de maíz del estado de Tlaxcala y el efecto que ha tenido la pluriactividad en el manejo del maíz y de otros recursos, así como en el desarrollo sustentable y humano. Con este fin se recurrió a información acopiada por una encuesta aplicada en el año de 2002 a una muestra de 1,884 maiceros. Los resultados indican que, aparte de producir maíz, 74% vende su fuerza de trabajo para sobrevivir, realizando distintas actividades; una sexta parte de productores o de sus familiares tienen que emigrar para contribuir al sustento familiar; las actividades pri- marias (siembra de maíz, ganadería y recolección de bienes, aunque aportan menor cantidad de recursos económicos, son estrategias de gran importancia por garantizar la reproducción social de la unidad campesina. Finalmente, no se encontró ninguna evidencia que demuestre que la política agropecuaria haya contribuido a mejorar la productividad, el bienestar social y la sustentabilidad de los recursos naturales de los productores de maíz del estado de Tlaxcala.

Evidence for ˜80-75 Ma subduction jump during Anatolide-Tauride-Armenian block accretion and ˜48 Ma Arabia-Eurasia collision in Lesser Caucasus-East Anatolia

Science.gov (United States)

Rolland, Yann; Perincek, Dogan; Kaymakci, Nuretdin; Sosson, Marc; Barrier, Eric; Avagyan, Ara

2012-05-01

Orogens formed by a combination of subduction and accretion are featured by a short-lived collisional history. They preserve crustal geometries acquired prior to the collisional event. These geometries comprise obducted oceanic crust sequences that may propagate somewhat far away from the suture zone, preserved accretionary prism and subduction channel at the interplate boundary. The cessation of deformation is ascribed to rapid jump of the subduction zone at the passive margin rim of the opposite side of the accreted block. Geological investigation and 40Ar/39Ar dating on the main tectonic boundaries of the Anatolide-Tauride-Armenian (ATA) block in Eastern Turkey, Armenia and Georgia provide temporal constraints of subduction and accretion on both sides of this small continental block, and final collisional history of Eurasian and Arabian plates. On the northern side, 40Ar/39Ar ages give insights for the subduction and collage from the Middle to Upper Cretaceous (95-80 Ma). To the south, younger magmatic and metamorphic ages exhibit subduction of Neotethys and accretion of the Bitlis-Pütürge block during the Upper Cretaceous (74-71 Ma). These data are interpreted as a subduction jump from the northern to the southern boundary of the ATA continental block at 80-75 Ma. Similar back-arc type geochemistry of obducted ophiolites in the two subduction-accretion domains point to a similar intra-oceanic evolution prior to accretion, featured by slab steepening and roll-back as for the current Mediterranean domain. Final closure of Neotethys and initiation of collision with Arabian Plate occurred in the Middle-Upper Eocene as featured by the development of a Himalayan-type thrust sheet exhuming amphibolite facies rocks in its hanging-wall at c. 48 Ma.

DaMaSCUS-CRUST: Dark Matter Simulation Code for Underground Scatterings - Crust Edition

Science.gov (United States)

Emken, Timon; Kouvaris, Chris

2018-03-01

DaMaSCUS-CRUST determines the critical cross-section for strongly interacting DM for various direct detection experiments systematically and precisely using Monte Carlo simulations of DM trajectories inside the Earth's crust, atmosphere, or any kind of shielding. Above a critical dark matter-nucleus scattering cross section, any terrestrial direct detection experiment loses sensitivity to dark matter, since the Earth crust, atmosphere, and potential shielding layers start to block off the dark matter particles. This critical cross section is commonly determined by describing the average energy loss of the dark matter particles analytically. However, this treatment overestimates the stopping power of the Earth crust; therefore, the obtained bounds should be considered as conservative. DaMaSCUS-CRUST is a modified version of DaMaSCUS (ascl:1706.003) that accounts for shielding effects and returns a precise exclusion band.

Non-economic determinants of structural transformations in Małopolska agriculture

Directory of Open Access Journals (Sweden)

Maciej Basaj

2009-01-01

Full Text Available In the article results of the research conducted in 2008 among farmers in two districts located in northern part of the Małopolska voivodeship have been presented. The aim of the article is the presentation of farmers’ opinions and attitudes against accomplishing structural alternations in their vicinity. Getting to know farmers’ intentions against the future of their farms, and also getting to know their estimations about the future of their farms in the vicinity can have particular significance in the prognosis and program of further development of rural areas – especially in such a region, with a big agrarian overpopulation as the Małopolska.

Limiares: Histoire( s) du cinéma de Jean-Luc Godard

OpenAIRE

Gervaiseau, Henri

2006-01-01

Neste artigo apresentamos a série videográfica Histoire(s) du cinéma, de Jean Luc Godard, apontamos as suas principais características, e efetuamos um primeiro exame da ordenação dos seus dois primeiros episódios. Discutimos de que modo Godard estabelece, nesta obra, uma trama poética de relações entre a história do século XX; a história do cinema e a sua própria estória enquanto sujeito enunciador. This article provides an introduction to the video series Histoire( s) du cinéma de Jean Lu...

Proceedings of the First PhD Symposium on Sustainable Ultrascale Computing Systems (NESUS PhD 2016)

OpenAIRE

Carretero Pérez, Jesús; García Blas, Javier; Petcu, Dana

2016-01-01

Proceedings of the First PhD Symposium on Sustainable Ultrascale Computing Systems (NESUS PhD 2016) Timisoara, Romania. February 8-11, 2016. The PhD Symposium was a very good opportunity for the young researchers to share information and knowledge, to present their current research, and to discuss topics with other students in order to look for synergies and common research topics. The idea was very successful and the assessment made by the PhD Student was very good. It also helped t...

Motion of the Rivera plate since 10 Ma relative to the Pacific and North American plates and the mantle

Science.gov (United States)

DeMets, Charles; Traylen, Stephen

2000-03-01

To better understand the influence of Rivera plate kinematics on the geodynamic evolution of western Mexico, we use more than 1400 crossings of seafloor spreading magnetic lineations along the Pacific-Rivera rise and northern Mathematician ridge to solve for rotations of the Rivera plate relative to the underlying mantle and the Pacific and North American plates at 14 times since 9.9 Ma. Our comparison of magnetic anomaly crossings from the undeformed Pacific plate to their counterparts on the Rivera plate indicates that significant areas of the Rivera plate have deformed since 9.9 Ma. Dextral shear along the southern edge of the plate from 3.3-2.2 Ma during a regional plate boundary reorganization deformed the Rivera plate farther into its interior than previously recognized. In addition, seafloor located north of two rupture zones within the Rivera plate sutured to North America after 1.5 Ma. Anomaly crossings from these two deformed regions thus cannot be used to reconstruct motion of the Rivera plate. Finite rotations that best reconstruct Pacific plate anomaly crossings onto their undeformed counterparts on the Rivera plate yield stage spreading rates that decrease gradually by 10% between 10 and 3.6 Ma, decrease rapidly by 20% after ˜3.6 Ma, and recover after 1 Ma. The slowdown in Pacific-Rivera seafloor spreading at 3.6 Ma coincided with the onset of dextral shear across the then-incipient southern boundary of the Rivera plate with the Pacific plate. The available evidence indicates that the Rivera plate has been an independent microplate since at least 10 Ma, contrary to published assertions that it fragmented from the Cocos plate at ˜5 Ma. Motion of the Rivera plate relative to North America has changed significantly since 10 Ma, in concert with significant changes in Pacific-Rivera motion. A significant and robust feature of Rivera-North America motion not previously recognized is the cessation of margin-normal convergence and thus subduction from 2

EFFECTIVENESS OF M.A. EPM PROGRAM LAUNCHED THROUGH DISTANCE EDUCATION SYSTEM OF ALLAMA IQBAL OPEN UNIVERSITY ISLAMABAD

Directory of Open Access Journals (Sweden)

Syed Manzoor HUSSAIN SHAH

2014-10-01

Full Text Available The study focus the effectiveness of the M.A EPM progam launched through distance education system of AIOU. For this purpose the performance of heads of educational institutions with and without M.A EPM degree was analyzed keeping in view different major aspects i.e. planning strategies, managerial approaches, coordination, administration and use of financial resources. The population of the study consisted of heads of educational institutions with and without MA EPM degree in Punjab. It was found that the performance of heads with EPM degree was better while planning strategies, management, coordination, following govt. policies, preparing annual budget and using financial resources as compared to heads without EPM degree. On the basis of the conclusions of the study it was recommended that MA EPM degree may be declared compulsory for heads of educational institutions. All the universities may start MA EPM degree to fulfill the requirements of working and professional educational planners and managers of the country.

A Precise 6 Ma Start Date for Fluvial Incision of the Northeastern Colorado Plateau Canyonlands

Science.gov (United States)

Thomson, S. N.; Soreghan, G. S.; Reiners, P. W.; Peyton, S. L.; Murray, K. E.

2015-12-01

Outstanding questions regarding late Cenozoic Colorado Plateau landscape evolution include: (1) the relative roles of isostatic rebound as result Colorado River incision versus longer-term geodynamic processes in driving overall rock uplift of the plateau; and (2) whether incision was triggered by river integration or by a change in deep-seated mantle lithosphere dynamics. A key to answering these questions is to date more precisely the onset of incision to refine previous estimates of between 6 and 10 Ma. We present new low-temperature thermochronologic results from bedrock and deep borehole samples in the northeastern Colorado Plateau to show that rapid river incision began here at 6 Ma (5.93±0.66 Ma) with incision rates increasing from 15-50 m/Myr to 160-200 m/Myr. The onset time is constrained independently by both inverse time-temperature modeling and by the break-in-slope in fission track age-elevation relationships. This new time constraint has several important implications. First, the coincidence in time with 5.97-5.3 Ma integration of the lower Colorado River through the Grand Canyon to the Gulf of California strongly favors downstream river integration triggering carving of the canyonlands of the upper Colorado River system. Second, it implies integration of the entire Colorado River system in less than 2 million years. Third, rock uplift of the plateau driven by the flexural isostatic response to river incision is restricted to just the last 6 Ma, as is associated increased sediment budget. Fourth, incision starting at 6 Ma means that previous estimates of upper Colorado River incision rates based on 10-12 Ma basalt datum levels are too low. This also changes the dependency of measured time interval on incision rate from a non-steady-state negative power-law dependence (exponent of -0.24) to a near steady-state dependence (exponent of 0.07) meaning that long-term upper Colorado river incision rates can provide a reliable proxy for rock uplift rates.

Correlation of transmissive fractures in holes OL-PH1, ONK-PH2 .. ONK-PH7 and ONKALO tunnel fractures

International Nuclear Information System (INIS)

Palmen, J; Nummela, J.; Ahokas, H.

2011-02-01

In a preceding study Posiva flow logging (PFL) with a 0.5 m test interval and 10 cm steps has been used together with optical drillhole images and core logging fracture data for the exact determination of the depth of hydraulically conductive fractures in pilot holes. The fracture traces has been mapped from the ONKALO tunnel walls as a part of the systematic mapping. The mapping results has been digitized to a 3D tunnel layout in Surpac Vision programme. The data integrity and fracture trace uniqueness has been verified by Datactica Oy and further collected to a database (Rakokanta D atactica P osiva20091119.mdb). Water leakage of the mapped fractures exists as an attribute field for each fracture, but the value of the attribute has not been assessed conclusively. Those fractures mapped with leakage attribute have been defined as flowing, dripping, wet, or damp where the attribute is recorded. The fractures with no leakage attribute value appear to be dry (not leaking) or the information is not available (assessment was not performed). The water leaking surfaces on ONKALO tunnel wall have been mapped sequentially and conclusively (twice a year) as a part of the Olkiluoto monitoring program (OMO) using an equal five step measure as used with fracture traces in systematic mapping. The PFL results correlated with core logging fracture data from pilot holes OL-PH1 and ONK-PH2 .. ONK-PH7 were in this work further correlated with the fractures mapped from the ONKALO tunnel walls. Each hydraulically conductive fracture of OL-PH1 and ONK-PH2 - ONK-PH7 was investigated and linked to ONKALO fracture of a coherent orientation and matching location, where such fracture trace was available. The main objective of the work was to identify the ONKALO fractures which correspond to the flow from fracture(s) identified with the PFL method in pilot holes and to collect basic information about the occurrence, frequency and orientation of water bearing fractures along ONKALO tunnel

The pH Game.

Science.gov (United States)

Chemecology, 1996

1996-01-01

Describes a game that can be used to teach students about the acidity of liquids and substances around their school and enable them to understand what pH levels tell us about the environment. Students collect samples and measure the pH of water, soil, plants, and other natural material. (DDR)

Zakrzepowa plamica małopłytkowa – diagnostyka i leczenie

Directory of Open Access Journals (Sweden)

Jolanta Korsak

2013-12-01

Full Text Available Zakrzepowa plamica małopłytkowa (thrombotic thrombocytopenic purpura, TTP początkowo charakteryzowała się pentadą objawów: małopłytkowością, niedokrwistością hemolityczną mikroangiopatyczną, zaburzeniami układu nerwowego, niewydolnością nerek i gorączką. Jednak u 35% chorych z rozpoznaniem TTP nie stwierdza się wszyst‑ kich tych dolegliwości: nie występują u nich objawy neurologiczne, zaburzenia funkcji nerek oraz gorączka. Obec‑ nie zakrzepową plamicę małopłytkową rozpoznaje się na podstawie małopłytkowości i niedokrwistości mikroangiopatycznej. Diagnostyka obejmuje badanie morfologiczne krwi obwodowej wraz z rozmazem, badanie czynności nerek i oznaczenie aktywności LDH. Pomocne w rozpoznaniu jest oznaczenie aktywności metaloprote‑ azy ADAMTS13 i miana przeciwciał anty-ADAMTS13. W terapii w pierwszym rzucie stosuje się plazmaferezę lecz‑ niczą – powinna ona zostać przeprowadzona nawet wtedy, gdy diagnoza jest niepewna. Plazmafereza usuwa mul‑ timery ULvWF i nabyte przeciwciała skierowane przeciw ADAMTS13. Przetoczenie osocza nie jest tak efektywne jak plazmafereza, lecz może być stosowane tymczasowo. Efekt leczenia oceniany jest na podstawie unormowa‑ nia się aktywności LDH oraz ustąpienia małopłytkowości, niedokrwistości i zmian neurologicznych. Inną możli‑ wością terapeutyczną jest podawanie glikokortykosteroidów oraz immunoglobulin. U niektórych chorych korzystne może być wykonanie splenektomii. Ostatnio stosuje się także rytuksymab – powoduje on redukcję miana inhibitora ADAMTS13 i wzrost aktywności enzymu. Po leczeniu rytuksymabem odnotowano remisje kliniczne w przypad‑ kach, w których zawiodły inne metody terapii.

pH distribution in human tumors

International Nuclear Information System (INIS)

Thistlethwaite, A.J.; Leeper, D.B.; Moylan, D.J.; Nerlinger, R.E.

1984-01-01

pH distribution in human tumors is being determined to evaluate this parameter as a prognostic indicator of hyperthermia response. pH is measured by a modified glass pH electrode (21g, model MI 408, Microelectrodes, Inc., Londonderry, NH) inserted through an 18g open-ended Angiocath. Eight tumors have been evaluated to date; and of those, 3 were also assayed after the first heat treatment coincident with determination of blood flow. Tumors were between 2-5 cm, of various histologies, and of primary, recurrent, or metastatic origin. 2-4 measurements were made per tumor. Pretreatment readings were between 6.4 and 7.2 pH units. As tumor blood flow increased after 1 hr heating (41.5 - 43 0 ) pH rose 0.1 - 0.3 units. Normal rat muscle yields pH readings of 7.35 - 7.45. Although there was considerable heterogeneity of pH within tumors, accuracy and drift were not a problem. 5-15 min were required for pH stabilization after catheter insertion and <5 min after electrode insertion. A saline wheal was used for anesthesia to preclude modification of pH by anesthetics. Patient tolerance has not been a problems. This study suggests that human tumor tissue has a preponderance of areas more acidic than normal tissue. This may serve to sensitize tumor cells to hyperthermia and provide a prognostic indicator of tumor response

MaMiCo: Transient multi-instance molecular-continuum flow simulation on supercomputers

Science.gov (United States)

Neumann, Philipp; Bian, Xin

2017-11-01

We present extensions of the macro-micro-coupling tool MaMiCo, which was designed to couple continuum fluid dynamics solvers with discrete particle dynamics. To enable local extraction of smooth flow field quantities especially on rather short time scales, sampling over an ensemble of molecular dynamics simulations is introduced. We provide details on these extensions including the transient coupling algorithm, open boundary forcing, and multi-instance sampling. Furthermore, we validate the coupling in Couette flow using different particle simulation software packages and particle models, i.e. molecular dynamics and dissipative particle dynamics. Finally, we demonstrate the parallel scalability of the molecular-continuum simulations by using up to 65 536 compute cores of the supercomputer Shaheen II located at KAUST. Program Files doi:http://dx.doi.org/10.17632/w7rgdrhb85.1 Licensing provisions: BSD 3-clause Programming language: C, C++ External routines/libraries: For compiling: SCons, MPI (optional) Subprograms used: ESPResSo, LAMMPS, ls1 mardyn, waLBerla For installation procedures of the MaMiCo interfaces, see the README files in the respective code directories located in coupling/interface/impl. Journal reference of previous version: P. Neumann, H. Flohr, R. Arora, P. Jarmatz, N. Tchipev, H.-J. Bungartz. MaMiCo: Software design for parallel molecular-continuum flow simulations, Computer Physics Communications 200: 324-335, 2016 Does the new version supersede the previous version?: Yes. The functionality of the previous version is completely retained in the new version. Nature of problem: Coupled molecular-continuum simulation for multi-resolution fluid dynamics: parts of the domain are resolved by molecular dynamics or another particle-based solver whereas large parts are covered by a mesh-based CFD solver, e.g. a lattice Boltzmann automaton. Solution method: We couple existing MD and CFD solvers via MaMiCo (macro-micro coupling tool). Data exchange and

Organising and learning experiences of the first semester MA Program ePedagogy / Visual Knowledge Building

NARCIS (Netherlands)

Jaap Jansen

2006-01-01

This paper will discuss the process of the MA program ePedagogy / Visual Knowledge Building during the first semester of the academic year 2005 – 2006. This MA program is a joint venture between the Universities of Helsinki, Hamburg and INHOLLAND. This publication will discuss and evaluate the

Overview of the SDSS-IV MaNGA Survey: Mapping nearby Galaxies at Apache Point Observatory

NARCIS (Netherlands)

Bundy, Kevin; Bershady, Matthew A.; Law, David R.; Yan, Renbin; Drory, Niv; MacDonald, Nicholas; Wake, David A.; Cherinka, Brian; Sánchez-Gallego, José R.; Weijmans, Anne-Marie; Thomas, Daniel; Tremonti, Christy; Masters, Karen; Coccato, Lodovico; Diamond-Stanic, Aleksandar M.; Aragón-Salamanca, Alfonso; Avila-Reese, Vladimir; Badenes, Carles; Falcón-Barroso, Jésus; Belfiore, Francesco; Bizyaev, Dmitry; Blanc, Guillermo A.; Bland-Hawthorn, Joss; Blanton, Michael R.; Brownstein, Joel R.; Byler, Nell; Cappellari, Michele; Conroy, Charlie; Dutton, Aaron A.; Emsellem, Eric; Etherington, James; Frinchaboy, Peter M.; Fu, Hai; Gunn, James E.; Harding, Paul; Johnston, Evelyn J.; Kauffmann, Guinevere; Kinemuchi, Karen; Klaene, Mark A.; Knapen, Johan H.; Leauthaud, Alexie; Li, Cheng; Lin, Lihwai; Maiolino, Roberto; Malanushenko, Viktor; Malanushenko, Elena; Mao, Shude; Maraston, Claudia; McDermid, Richard M.; Merrifield, Michael R.; Nichol, Robert C.; Oravetz, Daniel; Pan, Kaike; Parejko, John K.; Sanchez, Sebastian F.; Schlegel, David; Simmons, Audrey; Steele, Oliver; Steinmetz, Matthias; Thanjavur, Karun; Thompson, Benjamin A.; Tinker, Jeremy L.; van den Bosch, Remco C. E.; Westfall, Kyle B.; Wilkinson, David; Wright, Shelley; Xiao, Ting; Zhang, Kai

We present an overview of a new integral field spectroscopic survey called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory), one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV) that began on 2014 July 1. MaNGA will investigate the internal kinematic

Paleomagnetic study of 1765 Ma dyke swarm from the Singhbhum Craton: Implications to the paleogeography of India

Science.gov (United States)

Shankar, Ravi; Srinivasa Sarma, D.; Ramesh Babu, N.; Parashuramulu, V.

2018-05-01

We report the first key paleopole as a result of paleomagnetic study on a precisely dated 1765.3 ± 1.0 Ma WNW-ESE trending dyke swarm from Singhbhum Craton. This pole has been used in this study to propose the paleogeographic reconstruction of India with Baltica Craton and North China Craton. Incremental alternating field (AF) and thermal demagnetization, isolated high coercivity components with north to north-westerly declination and shallow negative inclination from 9 sampling sites which are representing different individual dykes. The primary origin of the ChRM is supported by the positive baked contact test. The WNW-ESE trending dykes yield a mean paleomagnetic direction with a declination = 329.2° and an inclination = -22.8° (k = 31.6; α95 = 9.3°). The positive bake contact test proves the primary nature of remanence. The pole position of Singhbhum Craton at 1765 Ma is 45°N, 311°E (dp = 5.2 and dm = 9.9). Paleogeographic reconstruction at ca. 1770 Ma, supported by geological, tectonic and metallogenic evidences indicate that the Baltica Craton and India linkage can be stable for at least ∼370 Ma (∼1770-1400 Ma). There is also reasonable evidence in support of India-North China Craton spatial proximity at ∼1770 Ma.

Forum for Almen Medicinske ph.d.-studerende

DEFF Research Database (Denmark)

Vedsted, Peter; Waldorff, Frans Boch; Eriksson, Tina

Rapport fra første fællesmøde mellem nuværende og kommende almenmedicinske ph.d.-studerende. Rapporten anbefaler dannelse af et egentligt almenmedicinsk ph.d.-forum, der søges optaget i DSAM som en interessegruppe. Ph.d.-forum betragter sig som en ressource ved forskellige initiativer og ønsker...... blandt andet at arbejde for en værdig ansættelse af yngre forskere. Blandt de konkrete forslag, Ph.d.-forum har stillet, er almenmedicinske ph.d.-kurser og ph.d.-stipendium med henblik på udarbejdelse af protokol....

Precio del maíz en México y ley del precio único

Directory of Open Access Journals (Sweden)

Miguel Ángel Martínez Damián

2017-01-01

Full Text Available El abasto de maíz debe cubrirse con importaciones de Estados Unidos de América ( ee. uu. . Si dicho intercambio es de libre comercio, entonces debe observarse la ley del precio único ( lpu . Bajo un modelo vectorial de corrección de error, se examina la lpu para el precio de maíz en México y ee. uu . Los resultados si bien rechazan estadísticamente la lpu , el vector cointegrante estimado es de signo y magnitud acorde con la lpu , dicho vector implica la existencia de una combinación lineal estacionaria que provee evidencia de integración de mercados. Secundariamente se encuentra que el precio de maíz en México es causado, en el sentido de Granger, por el precio en ee. uu. y que dicho precio no es exógeno al vector examinado.

Survey on the Labour Market Position of PhD Graduates: Competence comparison and relation between PhD and current employment

Energy Technology Data Exchange (ETDEWEB)

Heuritsch, J.; Waaijer, C.J.F.; Van der Weijden, I.C.M.

2016-07-01

We compared the skills PhD graduates acquired during their PhDs to the ones they need in their current job. We also studied the relation between PhD topic and content of the current job of recent PhD graduates. Data was collected in a survey of 1,133 respondents with a PhD from five Dutch universities between early 2008 and mid-2012. We show that scientific skills and independence are developed sufficiently during the PhD education, whereas PhDs are lacking in management and communication skills. These competence discrepancies were compared to the educational level required for the PhD holder’s current job and the relatedness of the current job to the PhD topic. (Author)

Gelatin–PMVE/MA composite scaffold promotes expansion of embryonic stem cells

International Nuclear Information System (INIS)

Chhabra, Hemlata; Gupta, Priyanka; Verma, Paul J.; Jadhav, Sameer; Bellare, Jayesh R.

2014-01-01

We introduce a new composite scaffold of gelatin and polymethyl vinyl ether-alt-maleic anhydride (PMVE/MA) for expansion of embryonic stem cells (ESCs) in an in vitro environment. To optimize the scaffold, we prepared a gelatin scaffold (G) and three composite scaffolds namely GP-1, GP-2, and GP-3 with varying PMVE/MA concentrations (0.2–1%) and characterized them by scanning electron microscopy (SEM), swelling study, compression testing and FTIR. SEM micrographs revealed interconnected porous structure in all the scaffolds. The permissible hemolysis ratio and activation of platelets by scaffolds confirmed the hemocompatibility of scaffolds. Initial biocompatibility assessment of scaffolds was conducted using hepatocarcinoma (Hep G2) cells and adhesion, proliferation and infiltration of Hep G2 cells in depth of scaffolds were observed, proving the scaffold's biocompatibility. Further Oct4B2 mouse embryonic stem cells (mESCs), which harbor a green fluorescence protein transgene under regulatory control of the Oct4 promotor, were examined for expansion on scaffolds with MTT assay. The GP-2 scaffold demonstrated the best cell proliferation and was further explored for ESC adherence and infiltration in depth (SEM and confocal), and pluripotent state of mESCs was assessed with the expression of Oct4-GFP and stage-specific embryonic antigen-1 (SSEA-1). This study reports the first demonstration of biocompatibility of gelatin–PMVE/MA composite scaffold and presents this scaffold as a promising candidate for embryonic stem cell based tissue engineering. - Highlights: • Composite scaffolds of gelatin and PMVE/MA were prepared by freeze-drying method. • SEM micrographs showed porous structure in all scaffolds of varying pore dimension. • GP-2 composite exhibited better cellular response in comparison to other scaffolds. • mESCs proliferated and expressed Oct-4 and SSEA-1, when cultured on GP-2 scaffold

Gelatin–PMVE/MA composite scaffold promotes expansion of embryonic stem cells

Energy Technology Data Exchange (ETDEWEB)

Chhabra, Hemlata [Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai (India); Gupta, Priyanka [Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai (India); IITB-Monash Research Academy, Mumbai (India); Department of Chemical Engineering, Monash University, Melbourne (Australia); Verma, Paul J. [Turretfield Research Centre, South Australian Research and Development Institute, Rosedale, South Australia (Australia); Jadhav, Sameer; Bellare, Jayesh R. [Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai (India)

2014-04-01

We introduce a new composite scaffold of gelatin and polymethyl vinyl ether-alt-maleic anhydride (PMVE/MA) for expansion of embryonic stem cells (ESCs) in an in vitro environment. To optimize the scaffold, we prepared a gelatin scaffold (G) and three composite scaffolds namely GP-1, GP-2, and GP-3 with varying PMVE/MA concentrations (0.2–1%) and characterized them by scanning electron microscopy (SEM), swelling study, compression testing and FTIR. SEM micrographs revealed interconnected porous structure in all the scaffolds. The permissible hemolysis ratio and activation of platelets by scaffolds confirmed the hemocompatibility of scaffolds. Initial biocompatibility assessment of scaffolds was conducted using hepatocarcinoma (Hep G2) cells and adhesion, proliferation and infiltration of Hep G2 cells in depth of scaffolds were observed, proving the scaffold's biocompatibility. Further Oct4B2 mouse embryonic stem cells (mESCs), which harbor a green fluorescence protein transgene under regulatory control of the Oct4 promotor, were examined for expansion on scaffolds with MTT assay. The GP-2 scaffold demonstrated the best cell proliferation and was further explored for ESC adherence and infiltration in depth (SEM and confocal), and pluripotent state of mESCs was assessed with the expression of Oct4-GFP and stage-specific embryonic antigen-1 (SSEA-1). This study reports the first demonstration of biocompatibility of gelatin–PMVE/MA composite scaffold and presents this scaffold as a promising candidate for embryonic stem cell based tissue engineering. - Highlights: • Composite scaffolds of gelatin and PMVE/MA were prepared by freeze-drying method. • SEM micrographs showed porous structure in all scaffolds of varying pore dimension. • GP-2 composite exhibited better cellular response in comparison to other scaffolds. • mESCs proliferated and expressed Oct-4 and SSEA-1, when cultured on GP-2 scaffold.

PhD supervisor-student relationship

Directory of Open Access Journals (Sweden)

FILIPE PRAZERES

2017-10-01

Full Text Available The relationship between the PhD supervisor and the PhD student is a complex one. When this relationship is neither effective nor efficient, it may yield negative consequences, such as academic failure (1. The intricacy of the supervisor-student relationship may be in part comparable to the one between the physician and his/her patient [see, for example (2]. Both interactions develop over several years and the players involved in each relationship – PhD supervisor-student on the one side and physician-patient on the other side – may at some point of the journey develop different expectations of one another [see, for example (3, 4] and experience emotional distress (5. In both relationships, the perceived satisfaction with the interaction will contribute to the success or failure of the treatment in one case, and in the other, the writing of a thesis. To improve the mentioned satisfaction, not only there is a need to invest time (6, as does the physician to his/ her patients, but also both the supervisor and the PhD student must be willing to negotiate a research path to follow that would be practical and achievable. The communication between the physician and patient is of paramount importance for the provision of health care (7, and so is the communication between the supervisor and PhD student which encourages the progression of both the research and the doctoral study (8. As to a smooth transition to the postgraduate life, supervisors should start thinking about providing the same kind of positive reinforcement that every student is used to experience in the undergraduate course. The recognition for a job well done will mean a lot for a PhD student, as it does for a patient. One good example is the increase in medication compliance by patients with high blood pressure who receive positive reinforcement from their physicians (9. Supervisors can organize regular meetings for (and with PhD students in order to not only discuss their projects

Biomedical PhD education - an international perspective

DEFF Research Database (Denmark)

Mulvany, Michael J.

2013-01-01

The PhD, otherwise known as the doctor of philosophy or Dr. Phil., is an internationally recognized degree, indicating that the PhD graduate has received training in research under supervision. Traditionally, the PhD was the route to an academic career, with most successful PhD graduates receiving...... tenured university positions. However, over the past 20–30 years, and particularly the past 10 years, the situation has changed dramatically. Governments in many countries have invested massively in PhD education, believing that trained researchers will contribute to the ‘knowledge society’, and thus...... increase the competitiveness of their countries in the future economies of the world. Thus, only a small fraction of PhD graduates now end up in academic research. Yet, the PhD remains a research degree, and indeed, institutions have become heavily dependent on PhD students for their research output...

Salivary pH: A diagnostic biomarker.

Science.gov (United States)

Baliga, Sharmila; Muglikar, Sangeeta; Kale, Rahul

2013-07-01

Saliva contains a variety of host defense factors. It influences calculus formation and periodontal disease. Different studies have been done to find exact correlation of salivary biomarkers with periodontal disease. With a multitude of biomarkers and complexities in their determination, the salivary pH may be tried to be used as a quick chairside test. The aim of this study was to analyze the pH of saliva and determine its relevance to the severity of periodontal disease. The study population consisted of 300 patients. They were divided into three groups of 100 patients each: Group A had clinically healthy gingiva, Group B who had generalized chronic gingivitis and Group C who had generalized chronic periodontitis. The randomized unstimulated saliva from each patient was collected and pH was tested. Data was analyzed statistically using analysis of variance technique. The salivary pH was more alkaline for patients with generalized chronic gingivitis as compared with the control group (P = 0.001) whereas patients with generalized chronic periodontitis had more acidic pH as compared with the control group (P = 0.001). These results indicate a significant change in the pH depending on the severity of the periodontal condition. The salivary pH shows significant changes and thus relevance to the severity of periodontal disease. Salivary pH may thus be used as a quick chairside diagnostic biomarker.

Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12

DEFF Research Database (Denmark)

Strømgaard, K; Bjørnsdottir, I; Andersen, K

2000-01-01

) of the enantiomers of PhTX-343 and PhTX-12. The methods were optimised with respect to chiral selector, buffer pH, and temperature around the capillary. Thus, rac-PhTX-343 was resolved using a separation buffer containing 30 mM heptakis-(2, 6-di-O-methyl)-beta-cyclodextrin in 50 mM 6-aminocarproic acid (pH 4. 0......) at 15 degrees C. rac-PhTX-12 was not resolvable in this system, but could be resolved using a separation buffer containing 10% w/v of dextrin 10, a linear maltodextrin, in 50 mM 6-aminocaproic acid (pH 4.0) at 15 degrees C. Using these methods, the optical purity of the synthetic enantiomers...

New compact hohlraum configuration research at the 1.7 MA Z-pinch generator

Energy Technology Data Exchange (ETDEWEB)

Kantsyrev, V. L., E-mail: victor@unr.edu; Shrestha, I. K.; Esaulov, A. A.; Safronova, A. S.; Shlyaptseva, V. V.; Osborne, G. C.; Astanovitsky, A. L.; Weller, M. E.; Stafford, A.; Schultz, K. A.; Cooper, M. C. [Physics Department, University of Nevada, Reno, NV 89557 (United States); Chuvatin, A. S. [Laboratorie de Physique des Plasmas, Ecole Polytechnique, 91128 Palaiseau (France); Rudakov, L. I. [Icarus Research Inc., P.O. Box 30780, Bethesda, MD 20824-0780 (United States); Velikovich, A. L. [Plasma Physics Division, Naval Research Laboratory, Washington, DC 20375 (United States); Cuneo, M. E.; Jones, B.; Vesey, R. A. [Sandia National Laboratories, Albuquerque, NM 87110 (United States)

2014-12-15

A new compact Z-pinch x-ray hohlraum design with parallel-driven x-ray sources was experimentally demonstrated in a full configuration with a central target and tailored shine shields (to provide a symmetric temperature distribution on the target) at the 1.7 MA Zebra generator. This presentation reports on the joint success of two independent lines of research. One of these was the development of new sources – planar wire arrays (PWAs). PWAs turned out to be a prolific radiator. Another success was the drastic improvement in energy efficiency of pulsed-power systems, such as the Load Current Multiplier (LCM). The Zebra/LCM generator almost doubled the plasma load current to 1.7 MA. The two above-mentioned innovative approaches were used in combination to produce a new compact hohlraum design for ICF, as jointly proposed by SNL and UNR. Good agreement between simulated and measured radiation temperature of the central target is shown. Experimental comparison of PWAs with planar foil liners (PFL) - another viable alternative to wire array loads at multi-MA generators show promising data. Results of research at the University of Nevada Reno allowed for the study of hohlraum coupling physics at University-scale generators. The advantages of new hohlraum design applications for multi-MA facilities with W or Au double PWAs or PFL x-ray sources are discussed.

Under-performance of listed companies? Real earnings management and M&A: Chinese empirical evidence

Directory of Open Access Journals (Sweden)

Ziqiao Zhang

2015-04-01

Full Text Available Purpose: The purpose of this paper is to examine whether acquiring firms attempt to adopt real earnings management strategy to upward reported earnings in the period of M&A announcement and provide an explanation for the underperformance of post-M&A in share payment M&A affairs occurring in China’s capital market from 2008-2010. Design/methodology/approach: The author uses Roychowdhury’s(2006 methodology to measure the magnitude of real earnings management of acquiring firms in stock for stock M&A by exploiting financial date from 2006 to 2011. The methodology includes three models, which are cash ?ow from operations, production costs and discretionary expenditures, respectively. Findings: It was found that firms using stock as a financing medium exhibit significant negative abnormal cash flows and abnormal discretionary expenses yet abnormal production costs significantly positive during the current period of M&A. Moreover, it was also documented that acquiring firms use real activities manipulation to overstate earnings for the purpose of improving market confidence. Finally, a negative association was found between REM and under-performance of post-M&A. Research limitations/implications: To some extent, these results explain the puzzle of performance decline over the following period of post-M&A. Meanwhile, our study adds to prior literature that capital market pressures induce acquiring firms inflate reported earnings by manipulating real activities in stock-financed M&A occurring in China’s capital market. Practical implications: The author’s result imply that investors, analysts and regulators cannot ignore more undetectable opportunism behaviors underlying reported earnings than accrual-based earnings management and the impact on the performance of post-M&A when they use financial statements to evaluate acquiring firms. Social implications: Our study plays important role in making public policies. Furthermore, it is necessary to

Contact Aligner 1 (Front and Back Side): Suss Microtec MA6

Data.gov (United States)

Federal Laboratory Consortium — Description:CORAL Name: SussMA6This system utilizes 1X contact lithography to transfer photomask patterns onto substrates Specifications / Capabilities:UV broadmand...

Finančné due diligence: teória a prax pri M&A transakciách

OpenAIRE

Vavrovič, Maroš

2015-01-01

This thesis focuses on financial due diligence within M&A transactions. In the first part, due diligence is characterized as one of the main factors of M&A failure. Due diligence process and definition is described afterwards, as well as purpose of due diligence, various types of due diligence and position of due diligence within individual phases of M&A transaction. Furthermore, financial due diligence and its main principles are defined. Essential differences between financial due diligence...

Phenomenology of MaVaN’s Models in Reactor Neutrino Data

Directory of Open Access Journals (Sweden)

M. F. Carneiro

2013-01-01

Full Text Available Mass Varying Neutrinos (MaVaN’s mechanisms were proposed to link the neutrino mass scale with the dark energy density, addressing the coincidence problem. In some scenarios, this mass can present a dependence on the baryonic density felt by neutrinos, creating an effective neutrino mass that depends both on the neutrino and baryonic densities. In this work, we study the phenomenological consequence of MaVaN’s scenarios in which the matter density dependence is induced by Yukawa interactions of a light neutral scalar particle which couples to neutrinos and matter. Under the assumption of one mass scale dominance, we perform an analysis of KamLAND neutrino data which depends on 4 parameters: the two standard oscillation parameters, Δm0,212 and tan2θ12, and two new coefficients which parameterize the environment dependence of neutrino mass. We introduce an Earth’s crust model to compute precisely the density in each point along the neutrino trajectory. We show that this new description of density does not affect the analysis with the standard model case. With the MaVaN model, we observe a first order effect in lower density, which leads to an improvement on the data description.

Construction of helium engineering demonstration loop (HENDEL M+A) for VHTR

International Nuclear Information System (INIS)

Shimomura, Saneaki; Tanaka, Toshiyuki; Nakano, Tadasuke

1983-01-01

The mother and adapter sections of the large structural component demonstration test loop, alias Helium Engineering Demonstration Loop, for the multipurpose, high temperature gas-cooled experimental reactor were completed in March, 1982. This facility was constructed by Fuji Electric Co., Ltd. and Kawasaki Heavy Industries Ltd. as the main contractors, and by the cooperation with Mitsubishi Heavy Industries Ltd. and Ishikawajima Harima Heavy Industries Co., Ltd. The HENDEL M+A is the testing facility of the largest scale in the world, which can handle 1000 deg C, 40 kgf/cm 2 G helium at a half flow rate of one core cooling loop of the experimental reactor. With the HENDEL M+A, the demonstration tests of fuel assembly stacks, in-core structures, large flow rate and high temperature equipment are planned. The HENDEL M+A comprises two mother loops, an adapter loop, and common auxiliary systems fon measurement and control (In), refining (Mp), makeup (Mu) and cooling water (Uc). The construction and function of such main equipment as a heater, circulators and internally insulated piping are described. The progress of the construction and the main experience during the construction, the process of operation and the performance are reported. (Kako, I.)

Effect of holding period prior to storage on the chemical attributes of Starking Delicious apples during refrigerated storage Efeito do período que antecede o armazenamento nos atributos químicos de maças Starking Delicious durante o armazenamento refrigerado

Directory of Open Access Journals (Sweden)

Aynur Batkan

2012-06-01

Full Text Available In this research, the effects of three different holding periods (6, 12 and 24 hours prior to storage on the quality attributes of Starking Delicious apples were investigated during storage of 8 months at 0.5 ± 1.0 ºC. Changes in weight loss, flesh firmness, pH values, soluble dry matter amount, titratable acidity values, ascorbic acid contents, and total and reducing sugar content were determined. According to the results, the holding period showed statistically significant changes in the quality attributes of the apples (p Neste trabalho, os efeitos de três diferentes tempos de espera (6, 12 e 24 horas antes do armazenamento sobre os atributos de qualidade de maçãs tipo Starking Delicious foram investigados durante o armazenamento de 8 meses a 0,5 ± 1,0 ºC. Alterações na perda de peso, firmeza da polpa, valores de pH, quantidade de matéria seca solúvel, valores de acidez titulável, teor de ácido ascórbico e teor de açúcar redutor e total das amostras foram determinadas. De acordo com os resultados da análise, o tempo de espera causou alterações estatisticamente significativas sobre as nos atributos de qualidade das maçãs (p < 0,05.

SDSS-IV MaNGA: Probing the Kinematic Morphology–Density Relation of Early-type Galaxies with MaNGA

Science.gov (United States)

Greene, J. E.; Leauthaud, A.; Emsellem, E.; Goddard, D.; Ge, J.; Andrews, B. H.; Brinkman, J.; Brownstein, J. R.; Greco, J.; Law, D.; Lin, Y.-T.; Masters, K. L.; Merrifield, M.; More, S.; Okabe, N.; Schneider, D. P.; Thomas, D.; Wake, D. A.; Yan, R.; Drory, N.

2017-12-01

The “kinematic” morphology–density relation for early-type galaxies posits that those galaxies with low angular momentum are preferentially found in the highest-density regions of the universe. We use a large sample of galaxy groups with halo masses {10}12.5MaNGA) survey to examine whether there is a correlation between local environment and rotational support that is independent of stellar mass. We find no compelling evidence for a relationship between the angular momentum content of early-type galaxies and either local overdensity or radial position within the group at fixed stellar mass.

The Authority and Charismas of Jack Ma's Leadership

Institute of Scientific and Technical Information of China (English)

陈希

2014-01-01

Jack Ma is the top manager of Ali Baba group, with a strong leadership. He mixes autocratic leadership and charismatic leadership together. The powers he used are from his position, the reward system of the company and the charismas to gain his leading power. In addition, he uses his charismas and his achievements to win the trust of the employees, which develop his leadership.

Endoscopic sensing of alveolar pH.

Science.gov (United States)

Choudhury, D; Tanner, M G; McAughtrie, S; Yu, F; Mills, B; Choudhary, T R; Seth, S; Craven, T H; Stone, J M; Mati, I K; Campbell, C J; Bradley, M; Williams, C K I; Dhaliwal, K; Birks, T A; Thomson, R R

2017-01-01

Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-to-fiber background ratio, and demonstrate multiple site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.

Exploring the Origin of Kinematically Irregular Galaxies with MaNGA

Science.gov (United States)

Stark, David Vincent; Bundy, Kevin; Westfall, Kyle; Bershady, Matthew; Cheung, Edmond; Soler, Juan; Brinchmann, Jarle; Abraham, Roberto; Bizyaev, Dmitry; Masters, Karen; Weijmans, Anne-Marie; Chen, Yanmei; Jin, Yifei; Drory, Niv; Lopes, Alexandre Roman; Law, David

2018-01-01

Deviations from normal rotation in galaxies may have a number of potential drivers, including tidal interactions, gas inflows/outflows, spiral structure, bar/oval distortions, or other internally generated instabilities. Thanks to new massive IFU surveys like MaNGA, we can now characterize the gas and stellar kinematics of thousands of galaxies in the local universe, enabling statistical analyses on the frequency of disturbed kinematics, their origin, and their impact on their host galaxies. We present a census of kinematics in MaNGA using a modified version of the Radon transform to map radial variations in kinematic position angles (PA). We discuss the frequency of kinematically irregular disks, and describe commonly observed patterns in radial PA profiles. In order to constrain the drivers of these kinematic signatures, we analyze how they correlate with galaxy mass, environment, star formation history, and gas-phase metallicity.

Characterisation and deployment of an immobilised pH sensor spot towards surface ocean pH measurements.

Science.gov (United States)

Clarke, Jennifer S; Achterberg, Eric P; Rérolle, Victoire M C; Abi Kaed Bey, Samer; Floquet, Cedric F A; Mowlem, Matthew C

2015-10-15

The oceans are a major sink for anthropogenic atmospheric carbon dioxide, and the uptake causes changes to the marine carbonate system and has wide ranging effects on flora and fauna. It is crucial to develop analytical systems that allow us to follow the increase in oceanic pCO2 and corresponding reduction in pH. Miniaturised sensor systems using immobilised fluorescence indicator spots are attractive for this purpose because of their simple design and low power requirements. The technology is increasingly used for oceanic dissolved oxygen measurements. We present a detailed method on the use of immobilised fluorescence indicator spots to determine pH in ocean waters across the pH range 7.6-8.2. We characterised temperature (-0.046 pH/°C from 5 to 25 °C) and salinity dependences (-0.01 pH/psu over 5-35), and performed a preliminary investigation into the influence of chlorophyll on the pH measurement. The apparent pKa of the sensor spots was 6.93 at 20 °C. A drift of 0.00014 R (ca. 0.0004 pH, at 25 °C, salinity 35) was observed over a 3 day period in a laboratory based drift experiment. We achieved a precision of 0.0074 pH units, and observed a drift of 0.06 pH units during a test deployment of 5 week duration in the Southern Ocean as an underway surface ocean sensor, which was corrected for using certified reference materials. The temperature and salinity dependences were accounted for with the algorithm, R=0.00034-0.17·pH+0.15·S(2)+0.0067·T-0.0084·S·1.075. This study provides a first step towards a pH optode system suitable for autonomous deployment. The use of a short duration low power illumination (LED current 0.2 mA, 5 μs illumination time) improved the lifetime and precision of the spot. Further improvements to the pH indicator spot operations include regular application of certified reference materials for drift correction and cross-calibration against a spectrophotometric pH system. Desirable future developments should involve novel

REM Sleep Behavior Disorder and Narcoleptic Features in Anti–Ma2-associated Encephalitis

Science.gov (United States)

Compta, Yaroslau; Iranzo, Alex; Santamaría, Joan; Casamitjana, Roser; Graus, Francesc

2007-01-01

A 69-year-old man with anti-Ma2 paraneoplastic encephalitis presented with subacute onset of severe hypersomnia, memory loss, parkinsonism, and gaze palsy. A brain magnetic resonance imaging study showed bilateral damage in the dorsolateral midbrain, amygdala, and paramedian thalami. Videopolysomnography disclosed rapid eye movement (REM) sleep behavior disorder, and a Multiple Sleep Latency Test showed a mean sleep latency of 7 minutes and 4 sleep-onset REM periods. The level of hypocretin-1 in the cerebrospinal fluid was low (49 pg/mL). This observation illustrates that REM sleep behavior disorder and narcoleptic features are 2 REM-sleep abnormalities that (1) may share the same autoimmune-mediated origin affecting the brainstem, limbic, and diencephalic structures and (2) may occur in the setting of the paraneoplastic anti–Ma2-associated encephalitis. Citation: Compta Y; Iranzo A; Santamaría J et al. REM Sleep Behavior Disorder and Narcoleptic Features in Anti–Ma2-associated Encephalitis. SLEEP 2007;30(6):767-769. PMID:17580598

Paradox of the peak-PCIM (Paleocene Carbon Isotope Maxima; ~57.8Ma) and Abrupt Global Warming

Science.gov (United States)

Harper, D. T.; Hoenisch, B.; Zachos, J. C.

2015-12-01

The Paleocene Carbon Isotope Maxima (PCIM; ~57.8Ma) represents a major transition in global δ13C during the late Paleocene, when the long-term positive trend in δ13C reversed from positive to negative. The peak-PCIM (~57.7Ma) has been tightly resolved in new high-resolution, astronomically-tuned benthic isotope records from IODP Sites 1209 (Pacific) and 1262 (Atlantic), which show the final phase of δ13C enrichment as abrupt (~1‰ in paradox as any rapid carbon release to the atmosphere should, in theory, create a negative excursion because all of the major carbon sources are isotopically light, whether volcanic outgassing, weathering/oxidation of organic carbon, or methane release [Dunkley-Jones et al., Phil. Trans. R. Soc. A 2010]. If global, there are several testable mechanisms that may explain the shift including increase in burial flux of light carbon, a reduction in heavy carbon burial flux, or a large-scale circulation change perhaps associated with the transition of a major oceanic gateway. Using trace metal (B/Ca and Mg/Ca) and stable isotope (δ11B, δ18O, and δ13C) geochemistry, here we establish the nature of the peak-PCIM at sites from 3 different ocean basins (IODP Sites 690, 1209, and 1262) and begin to test several of the possible mechanisms for change. Mg/Ca in mixed-layer planktonic foraminifera show 2-3°C of sea surface warming coinciding with, and abrupt as, the benthic carbon isotope enrichment at all sites. Bottom water Δ[CO32-], as indicated by B/Ca in benthic foraminifera, abruptly increases by 30-40µmol/kgsw. While this may indicate a change in bottom water circulation, surface B-based proxies also respond with a positive shift during the peak-PCIM indicating a slight increase in surface pH and highlighting the global nature of the event.

A Busy period analysis of the level dependent PH/PH/1/K queue

NARCIS (Netherlands)

Al Hanbali, Ahmad

2011-01-01

In this paper, we study the transient behavior of a level dependent single server queuing system with a waiting room of finite size during the busy period. The focus is on the level dependent PH/PH/1/K queue. We derive in closed form the joint transform of the length of the busy period, the number

Comparative study of two modes of gastroesophageal reflux measuring: conventional esophageal pH monitoring and wireless pH monitoring

Directory of Open Access Journals (Sweden)

Rimon Sobhi Azzam

2012-06-01

Full Text Available CONTEXT: Esophageal pH monitoring is considered to be the gold standard for the diagnosis of gastroesophageal acid reflux. However, this method is very troublesome and considerably limits the patient's routine activities. Wireless pH monitoring was developed to avoid these restrictions. OBJECTIVE: To compare the first 24 hours of the conventional and wireless pH monitoring, positioned 3 cm above the lower esophageal sphincter, in relation to: the occurrence of relevant technical failures, the ability to detect reflux and the ability to correlate the clinical symptoms to reflux. METHODS: Twenty-five patients referred for esophageal pH monitoring and with typical symptoms of gastroesophageal reflux disease were studied prospectively, underwent clinical interview, endoscopy, esophageal manometry and were submitted, with a simultaneous initial period, to 24-hour catheter pH monitoring and 48-hour wireless pH monitoring. RESULTS: Early capsule detachment occurred in one (4% case and there were no technical failures with the catheter pH monitoring (P = 0.463. Percentages of reflux time (total, upright and supine were higher with the wireless pH monitoring (P < 0.05. Pathological gastroesophageal reflux occurred in 16 (64% patients submitted to catheter and in 19 (76% to the capsule (P = 0.355. The symptom index was positive in 12 (48% patients with catheter pH monitoring and in 13 (52% with wireless pH monitoring (P = 0.777. CONCLUSIONS: 1 No significant differences were reported between the two methods of pH monitoring (capsule vs catheter, in regard to relevant technical failures; 2 Wireless pH monitoring detected higher percentages of reflux time than the conventional pH-metry; 3 The two methods of pH monitoring were comparable in diagnosis of pathological gastroesophageal reflux and comparable in correlating the clinical symptoms with the gastroesophageal reflux.

Hierarchical cobalt poly-phosphide hollow spheres as highly active and stable electrocatalysts for hydrogen evolution over a wide pH range

Science.gov (United States)

Wu, Tianli; Pi, Mingyu; Wang, Xiaodeng; Guo, Weimeng; Zhang, Dingke; Chen, Shijian

2018-01-01

Exploring highly-efficient and low-cost non-noble metal electrocatalyst toward the hydrogen evolution reaction (HER) is highly desired for renewable energy system but remains challenging. In this work, three dimensional hierarchical porous cobalt poly-phosphide hollow spheres (CoP3 HSs) were prepared by topotactic phosphidation of the cobalt-based precursor via vacuum encapsulation technique. As a porous HER cathode, the CoP3 HSs delivers remarkable electrocatalytic performance over the wide pH range. It needs overpotentials of -69 mV and -118 mV with a small Tafel slope of 51 mV dec-1 to obtain current densities of 10 mA cm-2 and 50 mA cm-2, respectively, and maintains its electrocatalytic performance over 30 h in acidic solution. In addition, CoP3 also exhibit superior electrocatalytic performance and stability under neutral and alkaline conditions for the HER. Both experimental measurements and density functional theory (DFT) calculations are performed to explore the mechanism behind the excellent HER performance. The results of our study make the porous CoP3 HSs as a promising electrocatalyst for practical applications toward energy conversion system and present a new way for designing and fabricating HER electrodes through high degree of phosphorization and nano-porous architecture.

pH Mapping on Tooth Surfaces for Quantitative Caries Diagnosis Using Micro Ir/IrOx pH Sensor.

Science.gov (United States)

Ratanaporncharoen, Chindanai; Tabata, Miyuki; Kitasako, Yuichi; Ikeda, Masaomi; Goda, Tatsuro; Matsumoto, Akira; Tagami, Junji; Miyahara, Yuji

2018-04-03

A quantitative diagnostic method for dental caries would improve oral health, which directly affects the quality of life. Here we describe the preparation and application of Ir/IrOx pH sensors, which are used to measure the surface pH of dental caries. The pH level is used as an indicator to distinguish between active and arrested caries. After a dentist visually inspected and defined 18 extracted dentinal caries at various positions as active or arrested caries, the surface pH values of sound and caries areas were directly measured with an Ir/IrOx pH sensor with a diameter of 300 μm as a dental explorer. The average pH values of the sound root, the arrested caries, and active caries were 6.85, 6.07, and 5.30, respectively. The pH obtained with an Ir/IrOx sensor was highly correlated with the inspection results by the dentist, indicating that the types of caries were successfully categorized. This caries testing technique using a micro Ir/IrOx pH sensor provides an accurate quantitative caries evaluation and has potential in clinical diagnosis.

Paraneoplastic antigen Ma2 autoantibodies as specific blood biomarkers for detection of early recurrence of small intestine neuroendocrine tumors.

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Tao Cui

Full Text Available BACKGROUND: Small intestine neuroendocrine tumors (SI-NETs belong to a rare group of cancers. Most patients have developed metastatic disease at the time of diagnosis, for which there is currently no cure. The delay in diagnosis is a major issue in the clinical management of the patients and new markers are urgently needed. We have previously identified paraneoplastic antigen Ma2 (PNMA2 as a novel SI-NET tissue biomarker. Therefore, we evaluated whether Ma2 autoantibodies detection in the blood stream is useful for the clinical diagnosis and recurrence of SI-NETs. METHODOLOGY/PRINCIPAL FINDINGS: A novel indirect ELISA was set up to detect Ma2 autoantibodies in blood samples of patients with SI-NET at different stages of disease. The analysis was extended to include typical and atypical lung carcinoids (TLC and ALC, to evaluate whether Ma2 autoantibodies in the blood stream become a general biomarker for NETs. In total, 124 blood samples of SI-NET patients at different stages of disease were included in the study. The novel Ma2 autoantibody ELISA showed high sensitivity, specificity and accuracy with ROC curve analysis underlying an area between 0.734 and 0.816. Ma2 autoantibodies in the blood from SI-NET patients were verified by western blot and sequential immunoprecipitation. Serum antibodies of patients stain Ma2 in the tumor tissue and neurons. We observed that SI-NET patients expressing Ma2 autoantibody levels below the cutoff had a longer progression and recurrence-free survival compared to those with higher titer. We also detected higher levels of Ma2 autoantibodies in blood samples from TLC and ALC patients than from healthy controls, as previously shown in small cell lung carcinoma samples. CONCLUSION: Here we show that high Ma2 autoantibody titer in the blood of SI-NET patients is a sensitive and specific biomarker, superior to chromogranin A (CgA for the risk of recurrence after radical operation of these tumors.

Paraneoplastic antigen Ma2 autoantibodies as specific blood biomarkers for detection of early recurrence of small intestine neuroendocrine tumors.

Science.gov (United States)

Cui, Tao; Hurtig, Monica; Elgue, Graciela; Li, Su-Chen; Veronesi, Giulia; Essaghir, Ahmed; Demoulin, Jean-Baptiste; Pelosi, Giuseppe; Alimohammadi, Mohammad; Öberg, Kjell; Giandomenico, Valeria

2010-12-30

Small intestine neuroendocrine tumors (SI-NETs) belong to a rare group of cancers. Most patients have developed metastatic disease at the time of diagnosis, for which there is currently no cure. The delay in diagnosis is a major issue in the clinical management of the patients and new markers are urgently needed. We have previously identified paraneoplastic antigen Ma2 (PNMA2) as a novel SI-NET tissue biomarker. Therefore, we evaluated whether Ma2 autoantibodies detection in the blood stream is useful for the clinical diagnosis and recurrence of SI-NETs. A novel indirect ELISA was set up to detect Ma2 autoantibodies in blood samples of patients with SI-NET at different stages of disease. The analysis was extended to include typical and atypical lung carcinoids (TLC and ALC), to evaluate whether Ma2 autoantibodies in the blood stream become a general biomarker for NETs. In total, 124 blood samples of SI-NET patients at different stages of disease were included in the study. The novel Ma2 autoantibody ELISA showed high sensitivity, specificity and accuracy with ROC curve analysis underlying an area between 0.734 and 0.816. Ma2 autoantibodies in the blood from SI-NET patients were verified by western blot and sequential immunoprecipitation. Serum antibodies of patients stain Ma2 in the tumor tissue and neurons. We observed that SI-NET patients expressing Ma2 autoantibody levels below the cutoff had a longer progression and recurrence-free survival compared to those with higher titer. We also detected higher levels of Ma2 autoantibodies in blood samples from TLC and ALC patients than from healthy controls, as previously shown in small cell lung carcinoma samples. Here we show that high Ma2 autoantibody titer in the blood of SI-NET patients is a sensitive and specific biomarker, superior to chromogranin A (CgA) for the risk of recurrence after radical operation of these tumors.

Salivary pH: A diagnostic biomarker

Directory of Open Access Journals (Sweden)

Sharmila Baliga

2013-01-01

Full Text Available Objectives: Saliva contains a variety of host defense factors. It influences calculus formation and periodontal disease. Different studies have been done to find exact correlation of salivary biomarkers with periodontal disease. With a multitude of biomarkers and complexities in their determination, the salivary pH may be tried to be used as a quick chairside test. The aim of this study was to analyze the pH of saliva and determine its relevance to the severity of periodontal disease. Study Design: The study population consisted of 300 patients. They were divided into three groups of 100 patients each: Group A had clinically healthy gingiva, Group B who had generalized chronic gingivitis and Group C who had generalized chronic periodontitis. The randomized unstimulated saliva from each patient was collected and pH was tested. Data was analyzed statistically using analysis of variance technique. Results: The salivary pH was more alkaline for patients with generalized chronic gingivitis as compared with the control group (P = 0.001 whereas patients with generalized chronic periodontitis had more acidic pH as compared with the control group (P = 0.001. Conclusion: These results indicate a significant change in the pH depending on the severity of the periodontal condition. The salivary pH shows significant changes and thus relevance to the severity of periodontal disease. Salivary pH may thus be used as a quick chairside diagnostic biomarker.

Implications of progesterone metabolism in MA-10 cells for accurate measurement of the rate of steroidogenesis

NARCIS (Netherlands)

F.F.G. Rommerts (Focko); S.R. King (Steven); P.N. Span (Paul)

2001-01-01

textabstractIn virtually all studies with MA-10 cells, progesterone RIAs have been used to measure steroid synthesis. To test whether progesterone is a stable end product, we investigated the metabolism of added tritiated progesterone and pregnenolone in MA-10 cells over a period

A novel synthetic analog of militarin, MA-1 induces mitochondrial dependent apoptosis by ROS generation in human lung cancer cells

International Nuclear Information System (INIS)

Yoon, Deok Hyo; Lim, Mi-Hee; Lee, Yu Ran; Sung, Gi-Ho; Lee, Tae-Ho; Jeon, Byeong Hwa; Cho, Jae Youl; Song, Won O.; Park, Haeil; Choi, Sunga; Kim, Tae Woong

2013-01-01

A synthetic Militarin analog-1[(2R,3R,4R,5R)-1,6-bis(4-(2,4,4-trimethylpentan-2-yl)phenoxy) hexane-2,3,4,5-tetraol] is a novel derivative of constituents from Cordyceps militaris, which has been used to treat a variety of chronic diseases including inflammation, diabetes, hyperglycemia and cancers. Here, we report for the first time the synthesis of Militarin analog-1 (MA-1) and the apoptotic mechanism of MA-1 against human lung cancer cell lines. Treatment with MA-1 significantly inhibited the viability of 3 human lung cancer cell lines. The inhibition of viability and growth in MA-1-treated A549 cells with an IC 50 of 5 μM were mediated through apoptosis induction, as demonstrated by an increase in DNA fragmentation, sub-G 0 /G 1 -DNA fraction, nuclear condensation, and phosphatidylserine exposure. The apoptotic cell death caused mitochondrial membrane permeabilization through regulation of expression of the Bcl-2 family proteins, leading to cytochrome c release in a time-dependent manner. Subsequently, the final stage of apoptosis, activation of caspase-9/-3 and cleavage of poly (ADP ribose) polymerase, was induced. Furthermore, A549 lung cancer cells were more responsive to MA-1 than a bronchial epithelial cell line (BEAS-2B), involving the rapid generation of reactive oxygen species (ROS), c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) activation. The pharmacological inhibition of ROS generation and JNK/p38 MAPK exhibited attenuated DNA fragmentation in MA-1-induced apoptosis. Oral administration of MA-1 also retarded growth of A549 orthotopic xenografts. In conclusion, the present study indicates that the new synthetic derivative MA-1 triggers mitochondrial apoptosis through ROS generation and regulation of MAPKs and may be a potent therapeutic agent against human lung cancer. - Highlights: • We report a novel synthesized derivative, militarin analog-1 (MA-1). • MA-1-induced cancer cell death was triggered by the ROS

A novel synthetic analog of militarin, MA-1 induces mitochondrial dependent apoptosis by ROS generation in human lung cancer cells

Energy Technology Data Exchange (ETDEWEB)

Yoon, Deok Hyo; Lim, Mi-Hee [Department of Biochemistry, Kangwon National University, Chuncheon 200-701 (Korea, Republic of); Lee, Yu Ran [Department of Physiology, School of Medicine, Chungnam National University, Daejeon 301-747 (Korea, Republic of); Sung, Gi-Ho [Mushroom Research Division, National Institute of Horticultural and Herbal Science, Rural Development Administration, Suwon 404-707 (Korea, Republic of); Lee, Tae-Ho [R and D Center, Dong-A Pharmaceutical Co, Ltd, Yongin 446-905 (Korea, Republic of); Jeon, Byeong Hwa [Department of Physiology, School of Medicine, Chungnam National University, Daejeon 301-747 (Korea, Republic of); Cho, Jae Youl [Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746 (Korea, Republic of); Song, Won O. [Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824 (United States); Park, Haeil [College of Pharmacy, Kangwon National University, Chuncheon 200-701 (Korea, Republic of); Choi, Sunga, E-mail: sachoi@cnu.ac.kr [Department of Physiology, School of Medicine, Chungnam National University, Daejeon 301-747 (Korea, Republic of); Kim, Tae Woong, E-mail: tawkim@kangwon.ac.kr [Department of Biochemistry, Kangwon National University, Chuncheon 200-701 (Korea, Republic of)

2013-12-15

A synthetic Militarin analog-1[(2R,3R,4R,5R)-1,6-bis(4-(2,4,4-trimethylpentan-2-yl)phenoxy) hexane-2,3,4,5-tetraol] is a novel derivative of constituents from Cordyceps militaris, which has been used to treat a variety of chronic diseases including inflammation, diabetes, hyperglycemia and cancers. Here, we report for the first time the synthesis of Militarin analog-1 (MA-1) and the apoptotic mechanism of MA-1 against human lung cancer cell lines. Treatment with MA-1 significantly inhibited the viability of 3 human lung cancer cell lines. The inhibition of viability and growth in MA-1-treated A549 cells with an IC{sub 50} of 5 μM were mediated through apoptosis induction, as demonstrated by an increase in DNA fragmentation, sub-G{sub 0}/G{sub 1}-DNA fraction, nuclear condensation, and phosphatidylserine exposure. The apoptotic cell death caused mitochondrial membrane permeabilization through regulation of expression of the Bcl-2 family proteins, leading to cytochrome c release in a time-dependent manner. Subsequently, the final stage of apoptosis, activation of caspase-9/-3 and cleavage of poly (ADP ribose) polymerase, was induced. Furthermore, A549 lung cancer cells were more responsive to MA-1 than a bronchial epithelial cell line (BEAS-2B), involving the rapid generation of reactive oxygen species (ROS), c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) activation. The pharmacological inhibition of ROS generation and JNK/p38 MAPK exhibited attenuated DNA fragmentation in MA-1-induced apoptosis. Oral administration of MA-1 also retarded growth of A549 orthotopic xenografts. In conclusion, the present study indicates that the new synthetic derivative MA-1 triggers mitochondrial apoptosis through ROS generation and regulation of MAPKs and may be a potent therapeutic agent against human lung cancer. - Highlights: • We report a novel synthesized derivative, militarin analog-1 (MA-1). • MA-1-induced cancer cell death was triggered by

Acid loading test (pH)

Science.gov (United States)

... this page: //medlineplus.gov/ency/article/003615.htm Acid loading test (pH) To use the sharing features on this page, please enable JavaScript. The acid loading test (pH) measures the ability of the ...

PhD students and integrative research

NARCIS (Netherlands)

Fry, G.; Tress, B.; Tress, G.

2006-01-01

The training of PhD students is currently very dynamic and varies widely from place to place. We present some examples of this variation and comment on how it may affect the way PhD students cope with integrative studies. Our focus is on the training needs of PhD students studying integrative

Cosmic Rays Accelerated at Cosmological Shock Waves Renyi Ma1 ...

Indian Academy of Sciences (India)

Cosmic Rays Accelerated at Cosmological Shock Waves. Renyi Ma1,2,∗ ... ratio of CR to thermal energy in the ICM and WHIM based on numerical simulations and diffusive shock ... Hence, the nonthermal radiation of CRs may provide us a.

Limbic encephalitis and antibodies to Ma2: a paraneoplastic presentation of breast cancer.

Science.gov (United States)

Sutton, I; Winer, J; Rowlands, D; Dalmau, J

2000-08-01

A patient with atypical medullary breast cancer is described who presented with symptoms of limbic encephalitis. The patient's serum and CSF contained antibodies that reacted with the nervous system and the tumour. These antibodies recognised Ma2, a neuronal protein related to paraneoplastic limbic and brainstem encephalitis in men with testicular tumours. This report highlights the importance of testing for paraneoplastic antineuronal antibodies in cases of unexplained limbic encephalitis and suggests screening for breast cancer in women with antibodies predominantly directed to Ma2.

Lysozyme-immobilized electrospun PAMA/PVA and PSSA-MA/PVA ion-exchange nanofiber for wound healing.

Science.gov (United States)

Tonglairoum, Prasopchai; Ngawhirunpat, Tanasait; Rojanarata, Theerasak; Opanasopit, Praneet

2014-08-27

Abstract This research was aimed to develop the lysozyme immobilized ion-exchange nanofiber mats for wound healing. To promote the healing process, the PSSA-MA/PVA and PAMA ion-exchange nanofiber mats were fabricated to mimic the extracellular matrix structure using electrospinning process followed by thermally crosslinked. Lysozyme was immobilized on the ion-exchane nanofibers by an adsorption method. The ion-exchange nanofibers were investigated using SEM, FTIR and XRPD. Moreover, the lysozyme-immobilized ion-exchange nanofibers were further investigated for lysozyme content and activity, lysozyme release and wound healing activity. The fiber diameters of the mats were in the nanometer range. Lysozyme was gradually absorbed into the PSSA-MA/PVA nanofiber with higher extend than that is absorbed on the PAMA/PVA nanofiber and exhibited higher activity than lysozyme-immobilized PAMA/PVA nanofiber. The total contents of lysozyme on the PSSA-MA/PVA and PAMA/PVA nanofiber were 648 and 166 µg/g, respectively. FTIR and lysozyme activity results confirmed the presence of lysozyme on the nanofiber mats. The lysozyme was released from the PSSA-MA/PVA and PAMA/PVA nanofiber in the same manner. The lysozyme-immobilized PSSA-MA/PVA nanofiber mats and lysozyme-immobilized PAMA/PVA nanofiber mats exhibited significantly faster healing rate than gauze and similar to the commercial antibacterial gauze dressing. These results suggest that these nanofiber mats could provide the promising candidate for wound healing application.

Pós colheita de bananas-maçã submetidas ao 1-MCP e armazenadas á temperatura ambiente Postharvest of 'apple' banana submetted to 1-MCP and storage in room temperature

Directory of Open Access Journals (Sweden)

Ana Carla Marque Pinheiro

2006-04-01

Full Text Available Bananas da cultivar Maçã foram adquiridas no estádio dois de coloração da casca (verde maturos e submetidas à ação de 1-MCP. O 1-MCP foi aplicado por 12 horas nas seguintes concentrações: 0 (controle, 50, 100, 150, 200 hL.L-1. Após aplicação, os frutos foram armazenados à temperatura ambiente (temperatura média 20ºC ± 1 e umidade relativa 80% ± 5 e avaliados à medida que atingiam os graus 3, 5 e 7 de coloração da casca. O tratamento com 1-MCP atrasou o início do amadurecimento de bananas-maçã armazenadas sob temperatura ambiente, baseado nas primeiras mudanças de coloração da casca. A aplicação de 1-MCP em bananas-maçã, ditou maiores valores de perda de massa e relação polpa/casca (nos graus 5 e 7 de coloração da casca. O 1-MCP, nas doses 100, 150 e 200 hL.L-1 de 1-MCP promoveu desverdecimento desuniforme e tonalidade avermelhada na casca. O tratamento 50 hL.L-1 de 1-MCP é o mais adequado, por promover a extensão da vida pós-colheita de bananas-maçã da cultivar armazenadas sob temperatura ambiente sem afetar a coloração da casca dos frutos, apresentando qualidade, baseando-se na cor da casca, firmeza, acidez titulável, pH e sólidos solúveis, semelhante ao controle.Mature green 'Apple' bananas were submitted to five concentrations of 1-MCP (0, 50, 100, 150 and 200 hL.L-1 for 12 hours. After treatment, the fruits were stored at room temperature (20ºC ± 1 and 80% ± 5 RH and analyzed at 3,5 and 7 color degree of peel. The treatment with 1-MCP delayed the start of the ripening based in the first changes of peel color. The treatment of 'Apple' bananas with 1-MCP promoted higher values of mass loss and pulp/peel ratio (5 and 7 degrees of color peel. The fruits treated with 100, 150 and 200 nL.L-1 of 1-MCP showed heterogeneous degreening and development of red color on the peel. 1-MCP at 50 nL.L-1 was the most appropriated treatment for promoting the extension of postharvest life of 'Apple' bananas stored

Status of Mirror Development for the Marshall Grazing Incidence X-ray Spectrometer (MaGIXS)

Science.gov (United States)

Champey, P. R.; Winebarger, A. R.; Kobayashi, K.; Savage, S. L.; Ramsey, B.; Kolodziejczak, J.; Speegle, C.; Young, M.; Kester, T.; Cheimets, P.; Hertz, E.

2017-12-01

The Marshall Grazing Incidence X-ray Spectrometer (MaGIXS) is a NASA sounding rocket instrument designed to observe soft X-ray emissions at 0.5 - 2.0 keV energies (24 - 6 Å) from a solar active region. MaGIXS will, for the first time, obtain spatially resolved spectra of high-temperature, low-emission plasma within an active region core. The unique optical design includes a Wolter I telescope and a 3-optic grazing incidence spectrograph. The spectrograph consists of a finite conjugate, stigmatic mirror pair and a planar varied line space grating. The grazing incidence mirrors are being developed at NASA Marshall Space Flight Center (MSFC) and are produced using electroform nickel-replication techniques, employing the same facilities developed for HERO, FOXSI, ART-XC and IXPE. The MaGIXS mirror mandrels have been fabricated, figured, and have completed the first phase of polishing. A set of three test shells were replicated and exposed to X-rays in the Stray Light Facility (SLF) at MSFC. Here we present results from mandrel metrology and X-ray testing at the SLF. We also discuss the development of a new polishing technique for the MaGIXS mirror mandrels, where we plan to use the Zeeko polishing machine.

Fetal scalp pH testing

Science.gov (United States)

Fetal scalp blood; Scalp pH testing; Fetal blood testing - scalp; Fetal distress - fetal scalp testing; Labor - fetal scalp testing ... a baby. In these cases, testing the scalp pH can help the doctor decide whether the fetus ...

Pb and Cd binding to natural freshwater biofilms developed at different pH: the important role of culture pH.

Science.gov (United States)

Hua, Xiuyi; Dong, Deming; Ding, Xiaoou; Yang, Fan; Jiang, Xu; Guo, Zhiyong

2013-01-01

The effects of solution pH on adsorption of trace metals to different types of natural aquatic solid materials have been studied extensively, but few studies have been carried out to investigate the effect of pH at which the solid materials were formed on the adsorption. The purpose of present study is to examine this effect of culture pH on metal adsorption to natural freshwater biofilms. The adsorption of Pb and Cd to biofilms which were developed at different culture pH values (ranging from 6.5 to 9.0) was measured at the same adsorption pH value (6.5). The culture pH had considerable effects on both composition and metal adsorption ability of the biofilms. Higher culture pH usually promoted the accumulation of organic material and Fe oxides in the biofilms. The culture pH also affected the quantity and species of algae in the biofilms. The adsorption of Pb and Cd to the biofilms generally increased with the increase of culture pH. This increase was minor at lower pH range and significant at higher pH range and was more remarkable for Cd adsorption than for Pb adsorption. The notable contribution of organic material to the adsorption at higher culture pH values was also observed. The profound impacts of culture pH on adsorption behavior of biofilms mainly resulted from the variation of total contents of the biofilm components and were also affected by the alteration of composition and properties of the components.

Ectopic Expression of the Grape Hyacinth (Muscari armeniacum R2R3-MYB Transcription Factor Gene, MaAN2, Induces Anthocyanin Accumulation in Tobacco

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Kaili Chen

2017-06-01

Full Text Available Anthocyanins are responsible for the different colors of ornamental plants. Grape hyacinth (Muscari armeniacum, a monocot plant with bulbous flowers, is popular for its fascinating blue color. In the present study, we functionally characterized an R2R3-MYB transcription factor gene MaAN2 from M. armeniacum. Our results indicated that MaAN2 participates in controlling anthocyanin biosynthesis. Sequence alignment and phylogenetic analysis suggested that MaAN2 belonged to the R2R3-MYB family AN2 subgroup. The anthocyanin accumulation of grape hyacinth flowers was positively correlated with the expression of MaAN2. And the transcriptional expression of MaAN2 was also consistent with that of M. armeniacum dihydroflavonol 4-reductase (MaDFR and M. armeniacum anthocyanidin synthase (MaANS in flowers. A dual luciferase transient expression assay indicated that when MaAN2 was co-inflitrated with Arabidopsis thaliana TRANSPARENT TESTA8 (AtTT8, it strongly activated the promoters of MaDFR and MaANS, but not the promoters of M. armeniacum chalcone synthase (MaCHS, M. armeniacum chalcone isomerase (MaCHI, and M. armeniacum flavanone 3-hydroxylase (MaF3H. Bimolecular fluorescence complementation assay confirmed that MaAN2 interacted with AtTT8 in vivo. The ectopic expression of MaAN2 in Nicotiana tabacum resulted in obvious red coloration of the leaves and much redder flowers. Almost all anthocyanin biosynthetic genes were remarkably upregulated in the leaves and flowers of the transgenic tobacco, and NtAn1a and NtAn1b (two basic helix–loop–helix anthocyanin regulatory genes were highly expressed in the transformed leaves, compared to the empty vector transformants. Collectively, our results suggest that MaAN2 plays a role in anthocyanin biosynthesis.

CONTINUOUS MEASUREMENT OF THE CYTOPLASMIC PH IN LACTOCOCCUS-LACTIS WITH A FLUORESCENT PH INDICATOR

NARCIS (Netherlands)

MOLENAAR, D; ABEE, T; KONINGS, WN

1991-01-01

The cytoplasmic pH of Lactococcus lactis was studied with the fluorescent pH indicator 2',7'-bis-(2-carboxyethyl)-5 (and-6)-carboxyfluorescein (BCECF). A novel method was applied for loading bacterial cells with BCECF, which consists of briefly treating a dense cell suspension with acid in the

Iridium Oxide pH Sensor Based on Stainless Steel Wire for pH Mapping on Metal Surface

Science.gov (United States)

Shahrestani, S.; Ismail, M. C.; Kakooei, S.; Beheshti, M.; Zabihiazadboni, M.; Zavareh, M. A.

2018-03-01

A simple technique to fabricate the iridium oxide pH sensor is useful in several applications such as medical, food processing and engineering material where it is able to detect the changes of pH. Generally, the fabrication technique can be classified into three types: electro-deposition iridium oxide film (EIrOF), activated iridium oxide film (AIROF) and sputtering iridium oxide film (SIROF). This study focuses on fabricating electrode, calibration and test. Electro-deposition iridium oxide film is a simple and effective method of fabricating this kind of sensor via cyclic voltammetry process. The iridium oxide thick film was successfully electrodeposited on the surface of stainless steel wire with 500 cycles of sweep potential. A further analysis under FESEM shows detailed image of iridium oxide film which has cauliflower-liked microstructure. EDX analysis shows the highest element present are iridium and oxygen which concluded that the process is successful. The iridium oxide based pH sensor has shown a good performance in comparison to conventional glass pH sensor when it is being calibrated in buffer solutions with 2, 4, 7 and 9 pH values. The iridium oxide pH sensor is specifically designed to measure the pH on the surface of metal plate.

Original Paper Production et qualité nutritionnelle des épis de maïs ...

African Journals Online (AJOL)

(richesse en amidon, présence de protéines, bonne matière grasse) et économiques (culture facile et peu coûteuse) qu'il offre (Adégbola et al., 2011). La production nationale de maïs a été estimée en 2012 à 1175 000 tonnes au. Bénin (FAO, 2013). Le niveau moyen de consommation de maïs est estimé à plus de 85.

Entropic derivation of F=ma for circular motion

International Nuclear Information System (INIS)

Duncan, Michael; Myrzakulov, Ratbay; Singleton, Douglas

2011-01-01

We examine the entropic picture of Newton's second law for the case of circular motion. It is shown that one must make modifications to the derivation of F=ma due to a change in the effective Unruh temperature for circular motion. These modifications present a challenge to the entropic derivation of Newton's second law, but also open up the possibility to experimentally test and constrain this model for large centripetal accelerations.

Implications of progesterone metabolism in MA-10 cells for accurate measurement of the rate of steroidogenesis.

NARCIS (Netherlands)

Rommerts, F.F.; King, S.R.; Span, P.N.

2001-01-01

In virtually all studies with MA-10 cells, progesterone RIAs have been used to measure steroid synthesis. To test whether progesterone is a stable end product, we investigated the metabolism of added tritiated progesterone and pregnenolone in MA-10 cells over a period of 3 h. Steroids were then

Carbon dots with strong excitation-dependent fluorescence changes towards pH. Application as nanosensors for a broad range of pH

Energy Technology Data Exchange (ETDEWEB)

Barati, Ali [Faculty of Chemistry, Institute for Advanced Studies in Basic Sciences, Zanjan (Iran, Islamic Republic of); Department of Chemistry, Razi University, Kermanshah (Iran, Islamic Republic of); Shamsipur, Mojtaba, E-mail: mshamsipur@yahoo.com [Department of Chemistry, Razi University, Kermanshah (Iran, Islamic Republic of); Abdollahi, Hamid, E-mail: abd@iasbs.ac.ir [Faculty of Chemistry, Institute for Advanced Studies in Basic Sciences, Zanjan (Iran, Islamic Republic of)

2016-08-10

In this study, preparation of novel pH-sensitive N-doped carbon dots (NCDs) using glucose and urea is reported. The prepared NCDs present strong excitation-dependent fluorescence changes towards the pH that is a new behavior from these nanomaterials. By taking advantage of this unique behavior, two separated ratiometric pH sensors using emission spectra of the NCDs for both acidic (pH 2.0 to 8.0) and basic (pH 7.0 to 14.0) ranges of pH are constructed. Additionally, by considering the entire Excitation–Emission Matrix (EEM) of NCDs as analytical signal and using a suitable multivariate calibration method, a broad range of pH from 2.0 to 14.0 was well calibrated. The multivariate calibration method was independent from the concentration of NCDs and resulted in a very low average prediction error of 0.067 pH units. No changes in the predicted pH under UV irradiation (for 3 h) and at high ionic strength (up to 2 M NaCl) indicated the high stability of this pH nanosensor. The practicality of this pH nanosensor for pH determination in real water samples was validated with good accuracy and repeatability. - Highlights: • Novel pH-sensitive carbon dots with strong FL changes towards pH are reported. • Ratiometric FL pH-sensors for both acidic and basic ranges of pH are constructed. • Multivariate calibration methods were used to calibrate a broad range of pH. • Using EEM of carbon dots and ANN, pH from 2.0 to 14.0 was well calibrated. • The pH prediction is stable even at high ionic strength up to 2 M NaCl.

Carbon dots with strong excitation-dependent fluorescence changes towards pH. Application as nanosensors for a broad range of pH

International Nuclear Information System (INIS)

Barati, Ali; Shamsipur, Mojtaba; Abdollahi, Hamid

2016-01-01

In this study, preparation of novel pH-sensitive N-doped carbon dots (NCDs) using glucose and urea is reported. The prepared NCDs present strong excitation-dependent fluorescence changes towards the pH that is a new behavior from these nanomaterials. By taking advantage of this unique behavior, two separated ratiometric pH sensors using emission spectra of the NCDs for both acidic (pH 2.0 to 8.0) and basic (pH 7.0 to 14.0) ranges of pH are constructed. Additionally, by considering the entire Excitation–Emission Matrix (EEM) of NCDs as analytical signal and using a suitable multivariate calibration method, a broad range of pH from 2.0 to 14.0 was well calibrated. The multivariate calibration method was independent from the concentration of NCDs and resulted in a very low average prediction error of 0.067 pH units. No changes in the predicted pH under UV irradiation (for 3 h) and at high ionic strength (up to 2 M NaCl) indicated the high stability of this pH nanosensor. The practicality of this pH nanosensor for pH determination in real water samples was validated with good accuracy and repeatability. - Highlights: • Novel pH-sensitive carbon dots with strong FL changes towards pH are reported. • Ratiometric FL pH-sensors for both acidic and basic ranges of pH are constructed. • Multivariate calibration methods were used to calibrate a broad range of pH. • Using EEM of carbon dots and ANN, pH from 2.0 to 14.0 was well calibrated. • The pH prediction is stable even at high ionic strength up to 2 M NaCl.

A 565 Ma old glaciation in the Ediacaran of peri-Gondwanan West Africa

Science.gov (United States)

Linnemann, Ulf; Pidal, Agustín Pieren; Hofmann, Mandy; Drost, Kerstin; Quesada, Cecilio; Gerdes, Axel; Marko, Linda; Gärtner, Andreas; Zieger, Johannes; Ulrich, Jens; Krause, Rita; Vickers-Rich, Patricia; Horak, Jana

2018-04-01

In the Cadomian orogen of the NE Bohemian Massif and of SW Iberia, a post-Gaskiers glacial event dated at c. 565 Ma has been detected. Such Ediacaran-aged glaciomarine deposits occur in the Weesenstein and Clanzschwitz groups of the Saxo-Thuringian zone (Bohemia) and in the Lower Alcudian group of the southern Central Iberian zone (Iberia). Both areas are parts of Cadomia situated in the Western and Central European Variscides. Glaciomarine sedimentary rocks are characterized by such features as dropstones, flat iron-shaped pebbles (" Bügeleisen- Geschiebe"), facetted pebbles, dreikanters, and zircon grains affected by ice abrasion. For age and provenance determination, LA-ICP-MS U-Pb ages ( n = 1124) and Hf isotope ( n = 446) analyses were performed. The maximum age of the glaciomarine deposits within a Cadomian back-arc basin based on U-Pb analytics resulted in the youngest detrital zircon populations showing ages of 562-565 Ma and of c. 566-576 Ma old zircon derived from granitoid pebbles within the diamictites. The youngest age recorded was 538-540 Ma based on zircon from the plutons which had intruded the previously deformed Ediacaran metasedimentary rocks. Previously described glaciomarine diamictites of Cadomia (Weesenstein, Clanzschwitz, and Orellana diamictites) are most definitely younger than the c. 579-581 Ma Gaskiers glaciation in Newfoundland (Gaskiers) and in SE New England (Squantum). We propose the term Weesenstein- Orellana glaciation for this new Ediacaran glacial event, named after the most relevant regions of exposure. Palaeogeographically, these glaciomarine diamictites and related sedimentary deposits lie on the periphery of the West African Craton (western peri-Gondwana), and evidence has been provided by detrital zircon U-Pb ages and their Hf isotope composition. Correlation with similar glaciomarine deposits in the Anti-Atlas (Bou Azzer) and Saudi Arabia suggests a continued distribution of post-Gaskiers glacial deposits along the

BioMaS: a modular pipeline for Bioinformatic analysis of Metagenomic AmpliconS.

Science.gov (United States)

Fosso, Bruno; Santamaria, Monica; Marzano, Marinella; Alonso-Alemany, Daniel; Valiente, Gabriel; Donvito, Giacinto; Monaco, Alfonso; Notarangelo, Pasquale; Pesole, Graziano

2015-07-01

Substantial advances in microbiology, molecular evolution and biodiversity have been carried out in recent years thanks to Metagenomics, which allows to unveil the composition and functions of mixed microbial communities in any environmental niche. If the investigation is aimed only at the microbiome taxonomic structure, a target-based metagenomic approach, here also referred as Meta-barcoding, is generally applied. This approach commonly involves the selective amplification of a species-specific genetic marker (DNA meta-barcode) in the whole taxonomic range of interest and the exploration of its taxon-related variants through High-Throughput Sequencing (HTS) technologies. The accessibility to proper computational systems for the large-scale bioinformatic analysis of HTS data represents, currently, one of the major challenges in advanced Meta-barcoding projects. BioMaS (Bioinformatic analysis of Metagenomic AmpliconS) is a new bioinformatic pipeline designed to support biomolecular researchers involved in taxonomic studies of environmental microbial communities by a completely automated workflow, comprehensive of all the fundamental steps, from raw sequence data upload and cleaning to final taxonomic identification, that are absolutely required in an appropriately designed Meta-barcoding HTS-based experiment. In its current version, BioMaS allows the analysis of both bacterial and fungal environments starting directly from the raw sequencing data from either Roche 454 or Illumina HTS platforms, following two alternative paths, respectively. BioMaS is implemented into a public web service available at https://recasgateway.ba.infn.it/ and is also available in Galaxy at http://galaxy.cloud.ba.infn.it:8080 (only for Illumina data). BioMaS is a friendly pipeline for Meta-barcoding HTS data analysis specifically designed for users without particular computing skills. A comparative benchmark, carried out by using a simulated dataset suitably designed to broadly represent

Les Offices du cinéma éducateur et l’émergence du parlant : l’exemple de l’Office de Nancy

OpenAIRE

Laborderie, Pascal

2014-01-01

Quelle fut la politique des Offices du cinéma scolaire et éducateur durant la période de généralisation du cinéma parlant ? Une première présentation du dispositif de l’Union française des offices du cinéma éducateur laïque permet de décrire les usages du cinéma par les instituteurs, soit dans leurs enseigne­ments (le cinéma scolaire), soit dans l’éducation des adolescents et des adultes (le cinéma éducateur). Puis une étude de l’Office régional d’enseignement cinématographique de Nancy, à pa...

Development of an accurate pH measurement methodology for the pore fluids of low pH cementitious materials

International Nuclear Information System (INIS)

Alonso, M. C.; Garcia Calvo, J. L.; Walker, C.

2012-08-01

The main objective of this project has been the development of an agreed set of protocols for the pH measurement of the pore fluid of a low pH cementitious material. Three protocols have been developed (Chapter 2), a reference method, based on pore fluid expression (PFE), and two routine methods with and without filtering, based on Ex Situ Leaching (ESL) procedures. Templates have been designed on which to record details of the pH measurement for the reference (PFE) method (Appendix C) and the routine (ESL) methods without and with filtering (Appendix D). Preliminary protocols were based on a broad review of the literature (Appendix A) and refined through a series of test experiments of the more critical parameters (Appendix B). After definition of the preliminary protocols, two phases of interlaboratory tests were performed. The first phase (Chapter 3) used the same low pH cement paste and enabled the nine participating laboratories to use, become familiar with and to identify any problems/uncertainties in the preliminary protocols. The reported pH values were subjected to a statistical analysis of the (within laboratory) repeatability and (between-laboratory) reproducibility and so provided a reliability test of the preliminary protocols. The second phase (Chapter 4) of interlaboratory tests used four different candidate low pH cementitious materials in the same nine laboratories, which allowed testing, validation and comparison of the reported pH values, which were obtained using the final protocols for the reference (PFE) and routine (ESL) methods by statistical analysis. The proposed final protocols (Chapter 2) have resulted in the reported pH values having low deviation and high reproducibility and repeatability. This will allow confidence in the pH value when selecting a candidate low pH cementitious material to be used in the engineered component of a high-level nuclear waste repository

Development of an accurate pH measurement methodology for the pore fluids of low pH cementitious materials

Energy Technology Data Exchange (ETDEWEB)

Alonso, M. C.; Garcia Calvo, J. L. [The Spanish National Research Council (CSIC), Madrid (Spain); Walker, C. [Japan Atomic Energy Agency (JAEA), Ibaraki (Japan)] [and others

2012-08-15

The main objective of this project has been the development of an agreed set of protocols for the pH measurement of the pore fluid of a low pH cementitious material. Three protocols have been developed (Chapter 2), a reference method, based on pore fluid expression (PFE), and two routine methods with and without filtering, based on Ex Situ Leaching (ESL) procedures. Templates have been designed on which to record details of the pH measurement for the reference (PFE) method (Appendix C) and the routine (ESL) methods without and with filtering (Appendix D). Preliminary protocols were based on a broad review of the literature (Appendix A) and refined through a series of test experiments of the more critical parameters (Appendix B). After definition of the preliminary protocols, two phases of interlaboratory tests were performed. The first phase (Chapter 3) used the same low pH cement paste and enabled the nine participating laboratories to use, become familiar with and to identify any problems/uncertainties in the preliminary protocols. The reported pH values were subjected to a statistical analysis of the (within laboratory) repeatability and (between-laboratory) reproducibility and so provided a reliability test of the preliminary protocols. The second phase (Chapter 4) of interlaboratory tests used four different candidate low pH cementitious materials in the same nine laboratories, which allowed testing, validation and comparison of the reported pH values, which were obtained using the final protocols for the reference (PFE) and routine (ESL) methods by statistical analysis. The proposed final protocols (Chapter 2) have resulted in the reported pH values having low deviation and high reproducibility and repeatability. This will allow confidence in the pH value when selecting a candidate low pH cementitious material to be used in the engineered component of a high-level nuclear waste repository.

Amperometric micro pH measurements in oxygenated saliva.

Science.gov (United States)

Chaisiwamongkhol, Korbua; Batchelor-McAuley, Christopher; Compton, Richard G

2017-07-24

An amperometric micro pH sensor has been developed based on the chemical oxidation of carbon fibre surfaces (diameter of 9 μm and length of ca. 1 mm) to enhance the population of surface quinone groups for the measurement of salivary pH. The pH analysis utilises the electrochemically reversible two-electron, two-proton behaviour of surface quinone groups on the micro-wire electrodes. A Nernstian response is observed across the pH range 2-8 which is the pH range of many biological fluids. We highlight the measurement of pH in small volumes of biological fluids without the need for oxygen removal and specifically the micro pH electrode is examined by measuring the pH of commercial synthetic saliva and authentic human saliva samples. The results correspond well with those obtained by using commercial glass pH electrodes on large volume samples.

An Intervention to Control Vasomotor Symptoms for Advanced PC Patients on Hormone Therapy

Science.gov (United States)

2014-08-01

radiation oncologists. In February 2014, Dr. Blacksburg left the Icahn School of Medicine, and referred us to another physician, Dr. Gupta , whose...Diefenbach, PhD; Simon J. Hall, MD; Phapichaya Chaoprang Herrera, MA; Jessica Lake, BS; Matt A. Hall, MA; Vinay Patel, BS; Glen W. McWilliams, MD; George A...Michael A. Diefenbach, PhD; Simon J. Hall, MD; Phapichaya Chaoprang Herrera, MA; George A. Dawson, MD; Glen W. McWilliams, MD; Vinay Patel, BS

CoMA, an instrument for the detailed in-situ analysis of collected cometary particulates

International Nuclear Information System (INIS)

Kissel, J.; Fechtig, H.; Jessberger, E.K.; Krueger, F.R.; Niemczyk, N.; Schaefer, G.; Zscheeg, H.

1988-01-01

The proposal for CoMA, a pulsed time-of-flight SIMS instrument to be flown onboard CRAF to rendezvous with a comet, had been accepted by NASA in October 1986. After several attempts it seems that funding by BMFT for the instrument pre-development phase can be obtained. Apart from that we made first essential progress in producing the primary ion pulses from an indium liquid metal ion source. Those pulses are needed to operate CoMA. (orig.)

Production et qualité nutritionnelle des épis de maïs frais bouillis ...

African Journals Online (AJOL)

Pour les transformatrices-vendeuses et les consommateurs, un bon maïs frais bouilli doit avoir une texture moins dure et un goût succulent. Les caractéristiques nutritionnelles du maïs frais bouilli révèlent une richesse en glucides totaux (63,4 à 64,6% matière sèche), en protéines (12,5% matière sèche), en minéraux (1,6% ...

Analysis list: ph-d [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ph-d Cell line,Embryo + dm3 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/p...h-d.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/ph-d.5.tsv http://dbarchive.biosciencedbc.jp.../kyushu-u/dm3/target/ph-d.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/ph-d.Cell_line.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/ph-d.Embryo.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/Cell_line.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Embryo.gml ...

Models for Theory-Based M.A. and Ph.D. Programs.

Science.gov (United States)

Botan, Carl; Vasquez, Gabriel

1999-01-01

Presents work accomplished at the 1998 National Communication Association Summer Conference. Outlines reasons for theory-based education in public relations. Presents an integrated model of student outcomes, curriculum, pedagogy, and assessment for theory-based master's and doctoral programs, including assumptions made and rationale for such…

Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training.

Science.gov (United States)

Goldberg, Charles; Insel, Paul A

2013-06-01

Many aspects of MD-PhD training are not optimally designed to prepare students for their future roles as translational clinician-scientists. The transition between PhD research efforts and clinical rotations is one hurdle that must be overcome. MD-PhD students have deficits in clinical skills compared with those of their MD-only colleagues at the time of this transition. Reimmersion programs (RPs) targeted to MD-PhD students have the potential to help them navigate this transition.The authors draw on their experience creating and implementing an RP that incorporates multiple types of activities (clinical exam review, objective structured clinical examination, and supervised practice in patient care settings) designed to enhance the participants' skills and readiness for clinical efforts. On the basis of this experience, they note that MD-PhD students' time away from the clinical environment negatively affects their clinical skills, causing them to feel underprepared for clinical rotations. The authors argue that participation in an RP can help students feel more comfortable speaking with and examining patients and decrease their anxiety regarding clinical encounters. The authors propose that RPs can have positive outcomes for improving the transition from PhD to clinical MD training in dual-degree programs. Identifying and addressing this and other transitions need to be considered to improve the educational experience of MD-PhD students.

Plant Habitat (PH)

Science.gov (United States)

Onate, Bryan

2016-01-01

The International Space Station (ISS) will soon have a platform for conducting fundamental research of Large Plants. Plant Habitat (PH) is designed to be a fully controllable environment for high-quality plant physiological research. PH will control light quality, level, and timing, temperature, CO2, relative humidity, and irrigation, while scrubbing ethylene. Additional capabilities include leaf temperature and root zone moisture and oxygen sensing. The light cap will have red (630 nm), blue (450 nm), green (525 nm), far red (730 nm) and broad spectrum white LEDs. There will be several internal cameras (visible and IR) to monitor and record plant growth and operations.

Programmable pH buffers

Science.gov (United States)

Gough, Dara Van; Huber, Dale L.; Bunker, Bruce C.; Roberts, Mark E.

2017-01-24

A programmable pH buffer comprises a copolymer that changes pK.sub.a at a lower critical solution temperature (LCST) in water. The copolymer comprises a thermally programmable polymer that undergoes a hydrophobic-to-hydrophilic phase change at the LCST and an electrolytic polymer that exhibits acid-base properties that are responsive to the phase change. The programmable pH buffer can be used to sequester CO.sub.2 into water.

SDSS IV MaNGA—Rotation Velocity Lags in the Extraplanar Ionized Gas from MaNGA Observations of Edge-on Galaxies

Energy Technology Data Exchange (ETDEWEB)

Bizyaev, D.; Pan, K.; Brinkmann, J. [Apache Point Observatory and New Mexico State University, Sunspot, NM 88349 (United States); Walterbos, R. A. M. [Department of Astronomy, New Mexico State University, Las Cruces, NM 88003 (United States); Yoachim, P. [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States); Riffel, R. A. [Departamento de Física, CCNE, Universidade Federal de Santa Maria, Av. Roraima, 1000-97105-900, Santa Maria, RS (Brazil); Fernández-Trincado, J. G. [Institut Utinam, CNRS UMR 6213, Université de Franche-Comté, OSU THETA Franche-Comté-Bourgogne, Observatoire de Besançon, BP 1615, F-25010 Besançon Cedex (France); Diamond-Stanic, A. M. [Department of Astronomy, University of Wisconsin-Madison, Madison, WI 53706 (United States); Jones, A. [Max-Planck Institute for Astrophysics, Karl-Schwarzschild-Str 1, Garching, D-85748 (Germany); Thomas, D. [Institute of Cosmology and Gravitation, University of Portsmouth, Dennis Sciama Building, Portsmouth PO1 3FX (United Kingdom); Cleary, J. [Department of Physics and Astronomy, Johns Hopkins University, Bloomberg Center, 3400 North Charles Street, Baltimore, MD 21218 (United States)

2017-04-20

We present a study of the kinematics of the extraplanar ionized gas around several dozen galaxies observed by the Mapping of Nearby Galaxies at the Apache Point Observatory (MaNGA) survey. We considered a sample of 67 edge-on galaxies out of more than 1400 extragalactic targets observed by MaNGA, in which we found 25 galaxies (or 37%) with regular lagging of the rotation curve at large distances from the galactic midplane. We model the observed H α emission velocity fields in the galaxies, taking projection effects and a simple model for the dust extinction into account. We show that the vertical lag of the rotation curve is necessary in the modeling, and estimate the lag amplitude in the galaxies. We find no correlation between the lag and the star formation rate in the galaxies. At the same time, we report a correlation between the lag and the galactic stellar mass, central stellar velocity dispersion, and axial ratio of the light distribution. These correlations suggest a possible higher ratio of infalling-to-local gas in early-type disk galaxies or a connection between lags and the possible presence of hot gaseous halos, which may be more prevalent in more massive galaxies. These results again demonstrate that observations of extraplanar gas can serve as a potential probe for accretion of gas.

SDSS IV MaNGA—Rotation Velocity Lags in the Extraplanar Ionized Gas from MaNGA Observations of Edge-on Galaxies

International Nuclear Information System (INIS)

Bizyaev, D.; Pan, K.; Brinkmann, J.; Walterbos, R. A. M.; Yoachim, P.; Riffel, R. A.; Fernández-Trincado, J. G.; Diamond-Stanic, A. M.; Jones, A.; Thomas, D.; Cleary, J.

2017-01-01

We present a study of the kinematics of the extraplanar ionized gas around several dozen galaxies observed by the Mapping of Nearby Galaxies at the Apache Point Observatory (MaNGA) survey. We considered a sample of 67 edge-on galaxies out of more than 1400 extragalactic targets observed by MaNGA, in which we found 25 galaxies (or 37%) with regular lagging of the rotation curve at large distances from the galactic midplane. We model the observed H α emission velocity fields in the galaxies, taking projection effects and a simple model for the dust extinction into account. We show that the vertical lag of the rotation curve is necessary in the modeling, and estimate the lag amplitude in the galaxies. We find no correlation between the lag and the star formation rate in the galaxies. At the same time, we report a correlation between the lag and the galactic stellar mass, central stellar velocity dispersion, and axial ratio of the light distribution. These correlations suggest a possible higher ratio of infalling-to-local gas in early-type disk galaxies or a connection between lags and the possible presence of hot gaseous halos, which may be more prevalent in more massive galaxies. These results again demonstrate that observations of extraplanar gas can serve as a potential probe for accretion of gas.

SDSS IV MaNGA—Rotation Velocity Lags in the Extraplanar Ionized Gas from MaNGA Observations of Edge-on Galaxies

Science.gov (United States)

Bizyaev, D.; Walterbos, R. A. M.; Yoachim, P.; Riffel, R. A.; Fernández-Trincado, J. G.; Pan, K.; Diamond-Stanic, A. M.; Jones, A.; Thomas, D.; Cleary, J.; Brinkmann, J.

2017-04-01

We present a study of the kinematics of the extraplanar ionized gas around several dozen galaxies observed by the Mapping of Nearby Galaxies at the Apache Point Observatory (MaNGA) survey. We considered a sample of 67 edge-on galaxies out of more than 1400 extragalactic targets observed by MaNGA, in which we found 25 galaxies (or 37%) with regular lagging of the rotation curve at large distances from the galactic midplane. We model the observed Hα emission velocity fields in the galaxies, taking projection effects and a simple model for the dust extinction into account. We show that the vertical lag of the rotation curve is necessary in the modeling, and estimate the lag amplitude in the galaxies. We find no correlation between the lag and the star formation rate in the galaxies. At the same time, we report a correlation between the lag and the galactic stellar mass, central stellar velocity dispersion, and axial ratio of the light distribution. These correlations suggest a possible higher ratio of infalling-to-local gas in early-type disk galaxies or a connection between lags and the possible presence of hot gaseous halos, which may be more prevalent in more massive galaxies. These results again demonstrate that observations of extraplanar gas can serve as a potential probe for accretion of gas.

Differential accumulation of β-carotene and tissue specific expression of phytoene synthase (MaPsy) gene in banana (Musa sp) cultivars.

Science.gov (United States)

Dhandapani, R; Singh, V P; Arora, A; Bhattacharya, R C; Rajendran, Ambika

2017-12-01

An experiment was conducted with twelve major Indian banana cultivars to investigate the molecular relationship between the differential accumulation of β-carotene in peel and pulp of the banana fruit and carotenoid biosynthetic pathway genes. The high performance liquid chromatography showed that all banana cultivars accumulated two-three fold more β-carotene in non-edible portion of the banana fruit. However, Nendran , a famous orange fleshed cultivar of South India, had high β-carotene content (1362 µg/100 g) in edible pulp. The gene encoding Musa accuminata phytoene synthase ( MaPsy ) was successfully amplified using a pair of degenerate primers designed from Oncidium orchid. The deduced amino acid sequences shared a high level of identity to phytoene synthase gene from other plants. Gene expression analysis confirmed the presence of two isoforms ( MaPsy1 and MaPsy2 ) of MaPsy gene in banana fruits. Presence of two isoforms of MaPsy gene in peel and one in pulp confirmed the differential accumulation of β-carotene in banana fruits. However, Nendran accumulated more β-carotene in edible pulp due to presence of both the isoforms of MaPsy gene. Thus, carotenoid accumulation is a tissue specific process strongly dependent on differential expression pattern of two isoforms of MaPsy gene in banana.

The PhD Conundrum in South African Academia

Science.gov (United States)

Breier, Mignonne; Herman, Chaya

2017-01-01

South African universities need more academics with PhDs, from historically disadvantaged population groups in particular, but they face a conundrum. In order to have more staff with PhDs, they need to produce more PhD graduates. But in order to produce more PhD graduates, they need more staff with PhDs to supervise. This article explores this…

redMaGiC: selecting luminous red galaxies from the DES Science Verification data

Energy Technology Data Exchange (ETDEWEB)

Rozo, E. [Univ. of Arizona, Tucson, AZ (United States). et al.

2016-05-30

We introduce redMaGiC, an automated algorithm for selecting Luminous Red Galaxies (LRGs). The algorithm was developed to minimize photometric redshift uncertainties in photometric large-scale structure studies. redMaGiC achieves this by self-training the color-cuts necessary to produce a luminosity-thresholded LRG sam- ple of constant comoving density. Additionally, we demonstrate that redMaGiC photo-zs are very nearly as accurate as the best machine-learning based methods, yet they require minimal spectroscopic training, do not suffer from extrapolation biases, and are very nearly Gaussian. We apply our algorithm to Dark Energy Survey (DES) Science Verification (SV) data to produce a redMaGiC catalog sampling the redshift range z ϵ [0.2,0.8]. Our fiducial sample has a comoving space density of 10^-3 (h^-1Mpc)^-3, and a median photo-z bias (z_spec z_photo) and scatter (σ_z=(1 + z)) of 0.005 and 0.017 respectively.The corresponding 5σ outlier fraction is 1.4%. We also test our algorithm with Sloan Digital Sky Survey (SDSS) Data Release 8 (DR8) and Stripe 82 data, and discuss how spectroscopic training can be used to control photo-z biases at the 0.1% level.

S&MA Internship to Support Orion and the European Service Module

Science.gov (United States)

Hutcheson, Connor

2016-01-01

As a University Space Research Association (USRA) intern for NASA Johnson Space Center (JSC) during the summer 2016 work term, I worked on three main projects for the Space Exploration Division (NC) of the Safety and Mission Assurance (S&MA) Directorate. I worked on all three projects concurrently. One of the projects involved facilitating the status and closure of technical actions that were created during European Service Module (ESM) safety reviews by the MPCV Safety & Engineering Review Panel (MSERP). The two main duties included accurately collecting and summarizing qualitative data, and communicating that information to the European Space Agency (ESA) and Airbus (ESA's prime contractor) in a clear, succinct and precise manner. This project also required that I create a report on the challenges and opportunities of international S&MA. With its heavy emphasis on soft skills, this project taught me how to communicate better, by showing me how to present and share information in an easy-to-read and understandable format, and by showing me how to cooperate with and culturally respect international partners on a technical project. The second project involved working with the Orion Thermal Protection System (TPS) Process Failure Modes and Effects Analysis (PFMEA) Working Group to create the first full version of the Orion TPS PFMEA. The Orion TPS PFMEA Working Group met twice a week to analyze the Avcoat block installation process for failure modes, the failure modes effects, and how such failure modes could be controlled. I was in charge of implementing changes that were discussed in meeting, but were not implemented real time. Another major task included creating a significant portion of the content alongside another team member outside the two weekly meetings. This project caused me to become knowledgeable about TPS, heatshields, space-rated manufacturing, and non-destructive evaluation (NDE). The project also helped me to become better at working with a small

Microscopic monitoring of extracellular pH in dental biofilms

DEFF Research Database (Denmark)

Schlafer, Sebastian; Garcia, Javier; Greve, Matilde

pH in dental biofilm is a key virulence factor for the development of caries lesions. The complex three-dimensional architecture of dental biofilms leads to steep gradients of nutrients and metabolites, including organic acids, across the biofilm. For decades, measuring pH in dental biofilm has...... been limited to monitoring bulk pH with electrodes. Although pH microelectrodes with a better spatial resolution have been developed, they do not permit to monitor horizontal pH gradients in real-time. Quantitative fluorescent microscopic techniques, such as fluorescence lifetime imaging or pH...... ratiometry, can be employed to map the pH landscape in dental biofilm with more detail. However, when pH sensitive fluorescent probes are used to visualize pH in biofilms, it is crucial to differentiate between extracellular and intracellular pH. Intracellular microbial pH and pH in the extracellular matrix...

78 FR 35756 - Drawbridge Operation Regulations; Charles River, Boston, MA

Science.gov (United States)

2013-06-14

... Regulations; Charles River, Boston, MA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from...) Bridge across the Charles River, mile 1.0, at Boston, Massachusetts. Under this temporary deviation the... Metropolitan District Commission (Craigie) Bridge, across the Charles River, mile 1.0, at Boston, Massachusetts...

Mechanisms of intragastric pH sensing.

Science.gov (United States)

Goo, Tyralee; Akiba, Yasutada; Kaunitz, Jonathan D

2010-12-01

Luminal amino acids and lack of luminal acidity as a result of acid neutralization by intragastric foodstuffs are powerful signals for acid secretion. Although the hormonal and neural pathways underlying this regulatory mechanism are well understood, the nature of the gastric luminal pH sensor has been enigmatic. In clinical studies, high pH, tryptic peptides, and luminal divalent metals (Ca(2+) and Mg(2+)) increase gastrin release and acid production. The calcium-sensing receptor (CaSR), first described in the parathyroid gland but expressed on gastric G cells, is a logical candidate for the gastric acid sensor. Because CaSR ligands include amino acids and divalent metals, and because extracellular pH affects ligand binding in the pH range of the gastric content, its pH, metal, and nutrient-sensing functions are consistent with physiologic observations. The CaSR is thus an attractive candidate for the gastric luminal sensor that is part of the neuroendocrine negative regulatory loop for acid secretion.

Determination Of Ph Including Hemoglobin Correction

Science.gov (United States)

Maynard, John D.; Hendee, Shonn P.; Rohrscheib, Mark R.; Nunez, David; Alam, M. Kathleen; Franke, James E.; Kemeny, Gabor J.

2005-09-13

Methods and apparatuses of determining the pH of a sample. A method can comprise determining an infrared spectrum of the sample, and determining the hemoglobin concentration of the sample. The hemoglobin concentration and the infrared spectrum can then be used to determine the pH of the sample. In some embodiments, the hemoglobin concentration can be used to select an model relating infrared spectra to pH that is applicable at the determined hemoglobin concentration. In other embodiments, a model relating hemoglobin concentration and infrared spectra to pH can be used. An apparatus according to the present invention can comprise an illumination system, adapted to supply radiation to a sample; a collection system, adapted to collect radiation expressed from the sample responsive to the incident radiation; and an analysis system, adapted to relate information about the incident radiation, the expressed radiation, and the hemoglobin concentration of the sample to pH.

PhMYB4 fine-tunes the floral volatile signature of Petunia x hybrida through PhC4H.

Science.gov (United States)

Colquhoun, Thomas A; Kim, Joo Young; Wedde, Ashlyn E; Levin, Laura A; Schmitt, Kyle C; Schuurink, Robert C; Clark, David G

2011-01-01

In Petunia × hybrida cv 'Mitchell Diploid' (MD), floral volatile benzenoid/phenylpropanoid (FVBP) biosynthesis is controlled spatially, developmentally, and daily at molecular, metabolic, and biochemical levels. Multiple genes have been shown to encode proteins that either directly catalyse a biochemical reaction yielding FVBP compounds or are involved in metabolite flux prior to the formation of FVBP compounds. It was hypothesized that multiple transcription factors are involved in the precise regulation of all necessary genes, resulting in the specific volatile signature of MD flowers. After acquiring all available petunia transcript sequences with homology to Arabidopsis thaliana R2R3-MYB transcription factors, PhMYB4 (named for its close identity to AtMYB4) was identified, cloned, and characterized. PhMYB4 transcripts accumulate to relatively high levels in floral tissues at anthesis and throughout open flower stages, which coincides with the spatial and developmental distribution of FVBP production and emission. Upon RNAi suppression of PhMYB4 (ir-PhMYB4) both petunia cinnamate-4-hydroxylase (PhC4H1 and PhC4H2) gene transcript levels were significantly increased. In addition, ir-PhMYB4 plants emit higher levels of FVBP compounds derived from p-coumaric acid (isoeugenol and eugenol) compared with MD. Together, these results indicate that PhMYB4 functions in the repression of C4H transcription, indirectly controlling the balance of FVBP production in petunia floral tissue (i.e. fine-tunes).

Decreasing Slip Rates From 12.8 Ma to Present on the Solitario Canyon Fault at Yucca Mountain, Nevada

International Nuclear Information System (INIS)

D. Buesch

2006-01-01

The Solitario Canyon fault, which bounds the west side of Yucca Mountain, Nevada, is the closest fault with Quaternary offset adjacent to the proposed spent nuclear fuel and high-level radioactive waste repository. Dip-slip offset between 12.8 and 10.7 Ma is determined from lithostratigraphic displacement in boreholes USW H-3 and USW WT-7, drilled in the footwall and hanging wall, respectively. The base of the 12.8-Ma Topopah Spring Tuff is interpreted to have 463.3 m of separation across the fault, an average dip slip rate of 0.036 mm/yr. Previous researchers identified a geothermal system active from 11.5 to 10.0 Ma with peak activity at 10.7 Ma that resulted in pervasive alteration of vitric rock to zeolitic minerals where the rocks were in the ground-water saturated zone. The contact between vitric (V) and pervasively zeolitic (Z) rocks cuts across the lithostratigraphic section and offset of this V-Z boundary can be used to measure slip rates between 12.8 and 10.7 Ma. In H-3, the V-Z boundary is 138.4 m below the base of the vitric, densely welded subzone of the Topopah Spring Tuff (Tptpv3). In WT-7, although the V-Z boundary is identified at the base of the Tptpv3, borehole video, cuttings, and geophysical log data indicate the Tptpv3 has well-developed zeolitic alteration along fractures, and this implies 19.5 m of the total thickness of Tptpv3 (and probably additional overlying crystallized rocks) also were in the saturated zone by 10.7 Ma. The V-Z relations across the Solitario Canyon fault in H-3 and WT-7 indicate a minimum of 157.9 m of separation before 10.7 Ma, which is 34.1 percent of the total slip of the Topopah Spring Tuff, and a minimum dip slip rate of 0.075 mm/yr from 12.8 to 10.7 Ma. These data are consistent with the broader structural history of the area near Yucca Mountain. Previous workers used angular unconformities, tilting of structural blocks, and paleomagnetic data to constrain the main period of extensional faulting between 12.7 and 8

Vietnam Inbound M&A Activity: The Role of Government Policy and Regulatory Environment

Directory of Open Access Journals (Sweden)

Jamshid C. Hosseini

2017-05-01

Full Text Available With a robust recent history of reform and opening, joining of the World Trade Organization, and negotiating a myriad of regional and global trade agreements, Vietnam has emerged as a promising destination for foreign direct investment(FDI and cross-border mergers and acquisitions (M&A. In this paper, we providean overview of Vietnam’s inbound mergers and acquisitions and review the twomain driving forces of inbound M&A, which are the legal framework reformprocess and the equitization of State-owned enterprises. We close by providingdirections for future research in the area of cross-border M&As.

Ambulatory oesophageal pH monitoring: a comparison between antimony, ISFET, and glass pH electrodes

NARCIS (Netherlands)

Hemmink, Gerrit J. M.; Weusten, Bas L. A. M.; Oors, Jac; Bredenoord, Albert J.; Timmer, Robin; Smout, André J. P. M.

2010-01-01

BACKGROUND AND AIM: Ambulatory oesophageal pH-impedance monitoring is a widely used test to evaluate patients with reflux symptoms. Several types of pH electrodes are available: antimony, ion sensitive field effect transistor (ISFET), and glass electrodes. These pH electrodes have not been compared

Schéma équivalent petit signal d\\'un transistor à effet de champ à ...

African Journals Online (AJOL)

Dans cet article, les auteurs présentent un schéma équivalent petit signal d\\'un transistor à effet de champ à base de nano tube de carbone (CNTFETs). Les éléments du schéma équivalent sont obtenus à partir de la mesure des paramètres « scattering » S du CNTFETs pour un point de polarisation dans une gamme de ...

Measurement of the Extracellular pH of Adherently Growing Mammalian Cells with High Spatial Resolution Using a Voltammetric pH Microsensor.

Science.gov (United States)

Munteanu, Raluca-Elena; Stǎnicǎ, Luciana; Gheorghiu, Mihaela; Gáspár, Szilveszter

2018-05-15

There are only a few tools suitable for measuring the extracellular pH of adherently growing mammalian cells with high spatial resolution, and none of them is widely used in laboratories around the world. Cell biologists very often limit themselves to measuring the intracellular pH with commercially available fluorescent probes. Therefore, we built a voltammetric pH microsensor and investigated its suitability for monitoring the extracellular pH of adherently growing mammalian cells. The voltammetric pH microsensor consisted of a 37 μm diameter carbon fiber microelectrode modified with reduced graphene oxide and syringaldazine. While graphene oxide was used to increase the electrochemically active surface area of our sensor, syringaldazine facilitated pH sensing through its pH-dependent electrochemical oxidation and reduction. The good sensitivity (60 ± 2.5 mV/pH unit), reproducibility (coefficient of variation ≤3% for the same pH measured with 5 different microsensors), and stability (pH drift around 0.05 units in 3 h) of the built voltammetric pH sensors were successfully used to investigate the acidification of the extracellular space of both cancer cells and normal cells. The results indicate that the developed pH microsensor and the perfected experimental protocol based on scanning electrochemical microscopy can reveal details of the pH regulation of cells not attainable with pH sensors lacking spatial resolution or which cannot be reproducibly positioned in the extracellular space.

Structural health monitoring results on Tsing Ma, Kap Shui Mun, and Ting Kau bridges

Science.gov (United States)

Wong, Kai-yuen; Chan, Wai-Yee K.; Man, King-Leung; Mak, W. L. N.; Lau, C. K.

2000-06-01

A structural health monitoring system has been installed in the cable-supported bridges located in the West of Hong Kong, i.e. the Tsing Ma Control Area. These cable-supported bridges are the Tsing Ma (Suspension) Bridge, the Kap Shu Mun (Cable- Stayed) Bridge and the Ting Kau (Cable-Stayed Bridge) Bridge. The monitoring system of Tsing Ma Bridge and Kap Shui Mun Bridge has been operated since May 1997, whereas the monitoring system of Ting Kau Bridge has been operated since November 1998. In past years, data received from the monitoring systems have been processed, and analyzed and archived. This paper first briefly outlines the operation of the data processing and analysis, and then presents: (1) the load effects monitoring results such as wind, temperature and traffic (highway and railway), and (2) the bridge responses monitoring results such as displacements, stresses/strains, accelerations and cables forces. Comparisons between monitoring results and design parameters and assumptions for the cable-supported bridges are also presented.

NMR characterisation of the minimal interacting regions of centrosomal proteins 4.1R and NuMA1: effect of phosphorylation

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Bruix Marta

2010-01-01

Full Text Available Abstract Background Some functions of 4.1R in non-erythroid cells are directly related with its distinct sub-cellular localisation during cell cycle phases. During mitosis, 4.1R is implicated in cell cycle progression and spindle pole formation, and co-localizes with NuMA1. However, during interphase 4.1R is located in the nucleus and only partially co-localizes with NuMA1. Results We have characterized by NMR the structural features of the C-terminal domain of 4.1R and those of the minimal region (the last 64 residues involved in the interaction with NuMA1. This subdomain behaves as an intrinsically unfolded protein containing a central region with helical tendency. The specific residues implicated in the interaction with NuMA1 have been mapped by NMR titrations and involve the N-terminal and central helical regions. The segment of NuMA1 that interacts with 4.1R is phosphorylated during mitosis. Interestingly, NMR data indicates that the phosphorylation of NuMA1 interacting peptide provokes a change in the interaction mechanism. In this case, the recognition occurs through the central helical region as well as through the C-terminal region of the subdomain meanwhile the N-terminal region do not interact. Conclusions These changes in the interaction derived from the phosphorylation state of NuMA1 suggest that phosphorylation can act as subtle mechanism of temporal and spatial regulation of the complex 4.1R-NuMA1 and therefore of the processes where both proteins play a role.

Coaching af ph.d.-studerende

DEFF Research Database (Denmark)

Godskesen, Mirjam Irene

Rapporten danner grundlag for at etablere et koncept for ph.d.-coaching. Erfaringerne fra et 2-årigt projekt om ph.d.-coaching i SCKK regi beskrives. De centrale temaer er tilrettelæggelse af den individuelle coaching, typiske temaer i coachingen og arbejdsdeling mellem coach og vejleder. Der er...

The potential of curcumin reagent as a natural pH indicator for the development of an optical pH sensor

International Nuclear Information System (INIS)

Rosmawani Mohammad; Musa Ahmad; Jamaluddin Mohd Daud

2007-01-01

The potential of curcumin reagent as a natural pH indicator for the development of an optical pH sensor was discussed in this study. Curcumin has been chosen because it has never been reported before for use in the development of an optical pH sensor. Curcumin is a coloring constituent of turmeric that giving yellow pigmentation. Curcumin showed clear color changes, for example yellow in acidic and reddish-brown in basic solutions. The color change is fast for example within 5 seconds. Results from the study showed that a linear pH range for this reagent was observed at pH 8-12 (R 2 =0.9854). Curcumin has a good photo stability with RSD value of 1.42 % for a study period of 6 months. The RSD values of the reproducibility study were found to be 1.43 % and 0.37 % for pH 9 and pH 12, respectively. Characterisation of the immobilised curcumin reagent also showed promising results, hence a good potential for use as a sensing reagent for an optical pH sensor. (author)

Voix-off et commentaire dans le cinéma documentaire et ethnographique

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Silvia Paggi

2011-07-01

Full Text Available Une analyse de la voix-off dans le cinéma documentaire – dont la fonction est avant tout le commentaire – où la relation texte/image est considérée comme fondamentale dans la genèse de la signification. Avec l’avènement du sonore, le commentaire occupe dans le cinéma documentaire « classique » une place prédominante, jusqu’à la fin des années Cinquante lorsque commence à s’affirmer la nouvelle stratégie de mise en scène du cinéma direct. Foncièrement critique envers le commentaire qu’il considérait comme trop chargé d’autorité, le cinéma direct instaure alors une autre relation avec le réel, restituant la parole aux protagonistes des actions représentées. L’analyse de la voix-off et du commentaire s’appuie sur des exemples cinématographiques – dont Flaherty, Buñuel, Ivens, Resnais, Marker, Rouch. De ce dernier, on analyse ensuite le commentaire mytho-poétique du film ethnographique Le Dama d’Ambara, considéré comme un exemple de la délicate quête d’équilibre entre l’expression artistique de la cinématographie et la communication scientifique de l’anthropologie.Un’analisi della voce-off nel cinema documentario, dove assicura innanzitutto una funzione di commento, prendendo come fondamentale nella produzione di significato la relazione testo/immagine. Con l’avvento del cinema sonoro, il commento assume nel documentario « classico » un’importanza predominante, fino alla fine degli anni cinquanta, quando comincia ad affermarsi la nuova strategia di realizzazione del cinema diretto. Fondamentalmente critico verso il commento che considera troppo carico d’autorità, ma anche della musica di sottofondo, il cinema diretto instaura una diversa relazione con il reale, restituendo la parola ai protagonisti dell’azione rappresentata. L’analisi della voce-off e del commento si appoggia su alcuni esempi cinematografici – tra cui Flaherty, Buñuel, Ivens, Resnais, Marker, Rouch. Di

A ph sensor based on a flexible substrate

Science.gov (United States)

Huang, Wen-Ding

pH sensor is an essential component used in many chemical, food, and bio-material industries. Conventional glass electrodes have been used to construct pH sensors, however, have some disadvantages. Glass electrodes are easily affected by alkaline or HF solution, they require a high input impedance pH meter, they often exhibit a sluggish response. In some specific applications, it is also difficult to use glass electrodes for in vivo biomedical or food monitoring applications due to the difficulty of size miniaturization, planarization and polymerization based on current manufacturing technologies. In this work, we have demonstrated a novel flexible pH sensor based on low-cost sol-gel fabrication process of iridium oxide (IrOx) sensing film (IROF). A pair of flexible miniature IrOx/AgCl electrode generated the action potential from the solution by electrochemical mechanism to obtain the pH level of the reagent. The fabrication process including sol-gel, thermal oxidation, and the electro-plating process of the silver chloride (AgCl) reference electrode were reported in the work. The IrOx film was verified and characterized using electron dispersive analysis (EDAX), scanning electron microscope (SEM), and x-ray diffraction (XRD). The flexible pH sensor's performance and characterization have been investigated with different testing parameters such as sensitivity, response time, stability, reversibility, repeatability, selectivity and temperature dependence. The flexible IrOx pH sensors exhibited promising sensing performance with a near-Nernstian response of sensitivity which is between --51.1mV/pH and --51.7mV/pH in different pH levels ranging from 1.5 to 12 at 25°C. Two applications including gastroesophageal reflux disease (GERD) diagnosis and food freshness wireless monitoring using our micro-flexible IrOx pH sensors were demonstrated. For the GERD diagnosing system, we embedded the micro flexible pH sensor on a 1.2cmx3.8cm of the capsule size of wireless sensor

In vivo intracellular pH measurements in tobacco and Arabidopsis reveal an unexpected pH gradient in the endomembrane system.

Science.gov (United States)

Martinière, Alexandre; Bassil, Elias; Jublanc, Elodie; Alcon, Carine; Reguera, Maria; Sentenac, Hervé; Blumwald, Eduardo; Paris, Nadine

2013-10-01

The pH homeostasis of endomembranes is essential for cellular functions. In order to provide direct pH measurements in the endomembrane system lumen, we targeted genetically encoded ratiometric pH sensors to the cytosol, the endoplasmic reticulum, and the trans-Golgi, or the compartments labeled by the vacuolar sorting receptor (VSR), which includes the trans-Golgi network and prevacuoles. Using noninvasive live-cell imaging to measure pH, we show that a gradual acidification from the endoplasmic reticulum to the lytic vacuole exists, in both tobacco (Nicotiana tabacum) epidermal (ΔpH -1.5) and Arabidopsis thaliana root cells (ΔpH -2.1). The average pH in VSR compartments was intermediate between that of the trans-Golgi and the vacuole. Combining pH measurements with in vivo colocalization experiments, we found that the trans-Golgi network had an acidic pH of 6.1, while the prevacuole and late prevacuole were both more alkaline, with pH of 6.6 and 7.1, respectively. We also showed that endosomal pH, and subsequently vacuolar trafficking of soluble proteins, requires both vacuolar-type H(+) ATPase-dependent acidification as well as proton efflux mediated at least by the activity of endosomal sodium/proton NHX-type antiporters.

Spectrophotometric Properties of E+A Galaxies in SDSS-IV MaNGA

Science.gov (United States)

Marinelli, Mariarosa; Dudley, Raymond; Edwards, Kay; Gonzalez, Andrea; Johnson, Amalya; Kerrison, Nicole; Melchert, Nancy; Ojanen, Winonah; Weaver, Olivia; Liu, Charles; SDSS-IV MaNGA

2018-01-01

Quenched post-starburst galaxies, or E+A galaxies, represent a unique and informative phase in the evolution of galaxies. We used a qualitative rubric-based methodology, informed by the literature, to manually select galaxies from the SDSS-IV IFU survey Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) using the single-fiber spectra from the Sloan Digital Sky Survey Data Release 8. Of the 2,812 galaxies observed so far in MaNGA, we found 39 galaxies meeting our criteria for E+A classification. Spectral energy distributions of these 39 galaxies from the far-UV to the mid-infrared demonstrate a heterogeneity in our sample emerging in the infrared, indicating many distinct paths to visually similar optical spectra. We used SDSS-IV MaNGA Pipe3D data products to analyze stellar population ages, and found that 34 galaxies exhibited stellar populations that were older at 1 effective radius than at the center of the galaxy. Given that our sample was manually chosen based on E+A markers in the single-fiber spectra aimed at the center of each galaxy, our E+A galaxies may have only experienced their significant starbursts in the central region, with a disk of quenched or quenching material further outward. This work was supported by grants AST-1460860 from the National Science Foundation and SDSS FAST/SSP-483 from the Alfred P. Sloan Foundation to the CUNY College of Staten Island.

MaRIE; a proposed materials facility at Los Alamos National Laboratory

Energy Technology Data Exchange (ETDEWEB)

Bourke, M.A.M. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)

2009-06-15

This presentation will describe the current definition of a proposed new facility called MaRIE at Los Alamos National Laboratory. The concept is of decadal scope and is predicated on the collocation of a fourth-generation X-ray light source with a proton accelerator spallation neutron source and complementary synthesis and characterization capabilities. MaRIE is an acronym which stands for Matter-Radiation Interactions in Extremes. The facility has been conceived partly in response to the increasing role that control science is expected to play in materials research compared to observation science. If new materials are to be implemented in a timely fashion for the most aggressive conditions of proposed fission and fusion energy applications they will have to rely, at least in part, on models, simulations and scientific insight. Validation of these models will require measurements at spatial and temporal scales that have only recently become enabled by the latest generations of light sources. A hallmark of the MaRIE concept is an emphasis on in situ studies (under extreme neutron, photon and ion irradiation conditions) of the phenomena that lead to swelling, phase transformations, thermal properties and corrosion. Insights and data, relevant to atomistic and quantum mechanical models, are major goals, as well as the facilitation of rapid materials discovery. It is hoped that this presentation will solicit input on aspects of the facility definition that should be strengthened or diminished to meet the needs of the fission community. (authors)

Apoptotic effect of cordycepin combined with cisplatin and/or paclitaxel on MA-10 mouse Leydig tumor cells

Directory of Open Access Journals (Sweden)

Kang FC

2015-09-01

Full Text Available Fu-Chi Kang,1 Pei-Jung Chen,2 Bo-Syong Pan,2,3 Meng-Shao Lai,2,3 Yung-Chia Chen,4 Bu-Miin Huang2,31Department of Anesthesia, Chi Mei Medical Center, Chiali, 2Department of Cell Biology and Anatomy, 3Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 4Department of Anatomy, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China Background: Chemotherapy is not limited to a single treatment, and the evidence demonstrates that different drug combinations can have positive results in patients. In this study, we sought to determine whether cordycepin combined with cisplatin and/or paclitaxel would have an additive effective on inducing apoptosis in mouse Leydig tumor cells, and the mechanisms were also briefly examined.Methods: The additive effects of cordycepin combined with cisplatin and/or paclitaxel on apoptosis in MA-10 cells were investigated by monitoring changes in morphological characteristics and examining cell viability, flow cytometry assays, and Western blot analyses.Results: Combination of cordycepin plus cisplatin and/or paclitaxel for 12 and 24 hours induced apoptotic features in MA-10 cells. The MTT assay showed that the combination treatment reduced the viability of MA-10 cells in a dose-dependent manner, with additive effects. Cell cycle analysis showed that combination treatment significantly increased subG1 phase cell numbers in MA-10 cells, indicating apoptosis. Moreover, cordycepin plus cisplatin and/or paclitaxel significantly induced cleavage of caspase-8, caspase-9, caspase-3, and poly ADP-ribose polymerase, and phosphorylation of c-Jun NH2-terminal kinase, extracellular signal-regulated kinase, p38, and p53 proteins in MA-10 cells.Conclusion: Cordycepin plus cisplatin and/or paclitaxel can have an additive effect on apoptosis in MA-10 cells, with activation of caspase, mitogen-activated protein kinase, and p53 signal pathways. Keywords: cordycepin

pH Sensing and Regulation in Cancer

OpenAIRE

Mehdi eDamaghi; Jonathan W. Wojtkowiak; Robert J. Gillies

2013-01-01

Cells maintain intracellular pH (pHi) within a narrow range (7.1-7.2) by controlling membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH sensors. These sensors have the ability to recognize and induce cellular responses to maintain the intracellular pH, often at the expense of acidifying the extracellular pH. In turn, extracellular acidification impacts cells via specific acid-sensing ion channels (ASICs) and proton-sensing G-protein coupled receptors (GPCRs...

Overexpression of the mulberry latex gene MaMLX-Q1 enhances defense against Plutella xylostella in Arabidopsis thaliana

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Liu Yan

2017-01-01

Full Text Available Purified mulberry latex chitinase (MLX has a role in defense against some lepidopteran insects. In this study, a full length chitinase gene, MaMLX-Q1, of 1405 bp with a 1140 bp open reading frame, was obtained from mulberry leaves by the degenerate primers and rapid amplification of cDNA ends polymerase chain reaction (RACE-PCR procedure. The gene encoded a mature protein with the predicted molecular mass of 39.38 kDa and an isoelectric point (pI of 6.43; it contained two chitin-binding domains and a hydrolase family 19 chitinase domain. Sequence alignment and phylogenetic analysis grouped it in the class I chitinase protein group. Heterogeneous expression of this MaMLX-Q1 in Arabidopsis showed non-visible alterations in growth phenotype, except for the higher transcriptional expression of MaMLX-Q1 when compared to that of wild-type Arabidopsis. This ectopic MaMLX-Q1 exhibited toxicity to the growth and development of Plutella xylostella larvae, causing significantly lower weight gain and higher mortality. These results indicate an application of MaMLX-Q1 as an insecticide for plant protection.

Update to Millstone 3 elevated pH tests

Energy Technology Data Exchange (ETDEWEB)

Bergmann, C.A.; Perock, J.D. [Westinghouse Electric Corp., Pittsburgh, PA (United States); Hudson, M.J.B.; King, R.W.; Macklin, S. [Northeast Utilities, Hartford, CT (United States)

1995-03-01

In view of the potential radiological benefits of elevated coolant pH operation, Northwest Utilities (NU), in support of an EPRI-Westinghouse program, agreed to operate the Millstone 3 plant at the start of its second fuel cycle as a demonstration of the effect of elevated coolant pH on out-of-core radiation fields. Operating with an elevated pH is defined as operating with an average lithium concentration of 3.35 ppm, until reaching an end of cycle pH of 7.2 or 7.4. The plant operated during its second and third cycles with an elevated coolant pH. The end of cycle pH during the second cycle was 7.4, and 7.2 during the third cycle. (During the first cycle, operation was with a coordinated pH of 7.0). Evaluation of the dose rate trends in Millstone 3 after two cycles of elevated coolant pH operation concluded that an elevated coolant pH resulted in a 15 percent lower component dose rate compared to other plants that operated with coordinated pH 6.9. However, due to a possible increase in fuel clad corrosion, operation during cycle 4 was restricted to pH 6.9 coordinated chemistry, with the exception of the last two months during which the pH increased to 7.35. At the end of cycle 4 (EOC4), there was a greater increase in component and crud trap dose rates than expected. This paper reviews the radiological trends in the plant and discusses the potential causes for the increase in the dose rates at EOC4.

Indications of 24-h esophageal pH monitoring, capsule pH monitoring, combined pH monitoring with multichannel impedance, esophageal manometry, radiology and scintigraphy in gastroesophageal reflux disease?

Science.gov (United States)

Vardar, Rukiye; Keskin, Muharrem

2017-12-01

Ambulatory esophageal pH monitoring is an essential method in patients exhibiting signs of non-erosive reflux disease (NERD) to make an objective diagnosis. Intra-esophageal pH monitoring is important in patients who are non-responsive to medications and in those with extraesophageal symptoms, particularly in NERD, before surgical interventions. With the help of the wireless capsule pH monitoring, measurements can be made under more physiological conditions as well as longer recordings can be performed because the investigation can be better tolerated by patients. Ambulatory esophageal pH monitoring can be detected within normal limits in 17%-31.4% of the patients with endoscopic esophagitis; therefore, normal pH monitoring cannot exclude the diagnosis of gastroesophageal reflux disease (GERD). Multi-channel intraluminal impedance pH (MII-pH) technology have been developed and currently the most sensitive tool to evaluate patients with both typical and atypical reflux symptoms. The sensitivity of a pH catheter test is 58% for the detection of acid reflux compared with MII-pH monitoring; further, its sensitivity is 28% for the detection of weak acid reflux compared with MII-pH monitoring. By adding impedance to pH catheter in patients with reflux symptoms, particularly in those receiving PPIs, it has been demonstrated that higher rates of diagnoses and symptom analyses can be obtained than those using only pH catheter. Esophageal manometry is used in the evaluation of patients with functional dysphagia and unexplained noncardiac chest pain and prior to antireflux surgery. The use of esophageal manometry is suitable for the detection of esophageal motor patterns and extreme motor abnormalities (e.g., achalasia and extreme hypomotility). Esophageal manometry and ambulatory pH monitoring are often used in assessments prior to laparoscopic antireflux surgery and in patients with reflux symptoms refractory to medical treatment. Although the esophageal motility is

The panacea toolbox of a PhD biomedical student.

Science.gov (United States)

Skaik, Younis

2014-01-01

Doing a PhD (doctor of philosophy) for the sake of contribution to knowledge should give the student an immense enthusiasm through the PhD period. It is the time in one's life that one spends to "hit the nail on the head" in a specific area and topic of interest. A PhD consists mostly of hard work and tenacity; however, luck and genius might also play a little role. You can pass all PhD phases without having both luck and genius. The PhD student should have pre-PhD and PhD toolboxes, which are "sine quibus non" for getting successfully a PhD degree. In this manuscript, the toolboxes of the PhD student are discussed.

Regulation of pH During Amelogenesis.

Science.gov (United States)

Lacruz, Rodrigo S; Nanci, Antonio; Kurtz, Ira; Wright, J Timothy; Paine, Michael L

2010-02-01

During amelogenesis, extracellular matrix proteins interact with growing hydroxyapatite crystals to create one of the most architecturally complex biological tissues. The process of enamel formation is a unique biomineralizing system characterized first by an increase in crystallite length during the secretory phase of amelogenesis, followed by a vast increase in crystallite width and thickness in the later maturation phase when organic complexes are enzymatically removed. Crystal growth is modulated by changes in the pH of the enamel microenvironment that is critical for proper enamel biomineralization. Whereas the genetic bases for most abnormal enamel phenotypes (amelogenesis imperfecta) are generally associated with mutations to enamel matrix specific genes, mutations to genes involved in pH regulation may result in severely affected enamel structure, highlighting the importance of pH regulation for normal enamel development. This review summarizes the intra- and extracellular mechanisms employed by the enamel-forming cells, ameloblasts, to maintain pH homeostasis and, also, discusses the enamel phenotypes associated with disruptions to genes involved in pH regulation.

Formation of continental crust in a temporally linked arc magma system from 5 to 30 km depth: ~ 90 Ma plutonism in the Cascades Crystalline Core composite arc section

Science.gov (United States)

Ratschbacher, B. C.; Miller, J. S.; Kent, A. J.; Miller, R. B.; Anderson, J. L.; Paterson, S. R.

2015-12-01

Continental crust has an andesitic bulk composition with a mafic lower crust and a granodioritic upper crust. The formation of stratified continental crust in general and the vertical extent of processes active in arc crustal columns leading to the differentiation of primitive, mantle-derived melts entering the lower crust are highly debated. To investigate where in the crustal column magma mixing, fractionation, assimilation and crystal growth occur and to what extent, we study the ~ 90 Ma magmatic flare-up event of the Cascades arc, a magma plumbing system from ~ 5 to 30 km depth. We focus on three intrusive complexes, emplaced at different depths during major regional shortening in an exceptionally thick crust (≥ 55 km1) but which are temporally related: the upper crustal Black Peak intrusion (1-3 kbar at 3.7 to 11 km; ~ 86.8 to 91.7 Ma2), the mid-crustal Mt. Stuart intrusion (3.5-4.0 kbar at 13 to 15 km; 90.8 and 96.3 Ma3) and the deep crustal Tenpeak intrusion (7 to 10 kbar at 25 to 37 km; 89.7 to 92.3 Ma4). These intrusive complexes are well characterized by geochronology showing that they have been constructed incrementally by multiple magma batches over their lifespans and thus allow the monitoring and comparison of geochemical parameters over time at different depths. We use a combination of whole rock major and trace element data and isotopes combined with detailed investigation of amphibole, which has been recognized to be important in the generation of calc-alkaline rocks in arcs to test the following hypotheses: (a) compositional bimodality is produced in the lower crust, whereas upper crustal levels are dominated by mixing to form intermediate compositions, or (b) differentiation occurs throughout the crustal column with different crystallizing phases and their compositions controlling the bulk chemistry. 1. Miller et al. 2009: GSA Special Paper 456, p. 125-149 2. Shea 2014: PhD thesis, Massachusetts Institute of Technology 3. Anderson et al. 2012

Functional Equivalence of Retroviral MA Domains in Facilitating Psi RNA Binding Specificity by Gag

Directory of Open Access Journals (Sweden)

Tiffiny Rye-McCurdy

2016-09-01

Full Text Available Retroviruses specifically package full-length, dimeric genomic RNA (gRNA even in the presence of a vast excess of cellular RNA. The “psi” (Ψ element within the 5′-untranslated region (5′UTR of gRNA is critical for packaging through interaction with the nucleocapsid (NC domain of Gag. However, in vitro Gag binding affinity for Ψ versus non-Ψ RNAs is not significantly different. Previous salt-titration binding assays revealed that human immunodeficiency virus type 1 (HIV-1 Gag bound to Ψ RNA with high specificity and relatively few charge interactions, whereas binding to non-Ψ RNA was less specific and involved more electrostatic interactions. The NC domain was critical for specific Ψ binding, but surprisingly, a Gag mutant lacking the matrix (MA domain was less effective at discriminating Ψ from non-Ψ RNA. We now find that Rous sarcoma virus (RSV Gag also effectively discriminates RSV Ψ from non-Ψ RNA in a MA-dependent manner. Interestingly, Gag chimeras, wherein the HIV-1 and RSV MA domains were swapped, maintained high binding specificity to cognate Ψ RNAs. Using Ψ RNA mutant constructs, determinants responsible for promoting high Gag binding specificity were identified in both systems. Taken together, these studies reveal the functional equivalence of HIV-1 and RSV MA domains in facilitating Ψ RNA selectivity by Gag, as well as Ψ elements that promote this selectivity.

Renal responses of trout to chronic respiratory and metabolic acidoses and metabolic alkalosis.

Science.gov (United States)

Wood, C M; Milligan, C L; Walsh, P J

1999-08-01