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Sample records for m3 electronic resource

  1. Low-lying electronic states of M(3)O(9)(-) and M(3)O(9)(2-) (M = Mo, W).

    Science.gov (United States)

    Li, Shenggang; Dixon, David A

    2007-11-01

    Multiple low-lying electronic states of M(3)O(9)(-) and M(3)O(9)(2-) (M = Mo, W) arise from the occupation of the near-degenerate low-lying virtual orbitals in the neutral clusters. We used density functional theory (DFT) and coupled cluster theory (CCSD(T)) with correlation consistent basis sets to study the structures and energetics of the electronic states of these anions. The adiabatic and vertical electron detachment energies (ADEs and VDEs) of the anionic clusters were calculated with 27 exchange-correlation functionals including one local spin density approximation functional, 13 generalized gradient approximation (GGA) functionals, and 13 hybrid GGA functionals, as well as the CCSD(T) method. For M(3)O(9)(-), CCSD(T) and nearly all of the DFT exchange-correlation functionals studied predict the (2)A(1) state arising from the Jahn-Teller distortion due to singly occupying the degenerate e' orbital to be lower in energy than the (2)A(1)' state arising from singly occupying the nondegenerate a(1)' orbital. For W(3)O(9)(-), the (2)A(1) state was predicted to have essentially the same energy as the (2)A(1)' state at the CCSD(T) level with core-valence correlation corrections included and to be higher in energy or essentially isoenergetic with most DFT methods. The calculated VDEs from the CCSD(T) method are in reasonable agreement with the experimental values for both electronic states if estimates for the corrections due to basis set incompleteness are included. For M(3)O(9)(2-), the singlet state arising from doubly occupying the nondegenerate a(1)' orbital was predicted to be the most stable state for both M = Mo and W. However, whereas M(3)O(9)(2-) was predicted to be less stable than M(3)O(9)(-), W(3)O(9)(2-) was predicted to be more stable than W(3)O(9)(-).

  2. Relativistic electrons high doses at International Space Station and Foton M2/M3 satellites

    Science.gov (United States)

    Dachev, T. P.; Tomov, B.; Matviichuk, Yu.; Dimitrov, Pl.; Bankov, N.

    2009-12-01

    The paper presents observation of relativistic electrons. Data are collected by the Radiation Risk Radiometer-Dosimeters (R3D) B2/B3 modifications during the flights of Foton M2/M3 satellites in 2005 and 2007 as well as by the R3DE instrument at the European Technology Exposure Facility (EuTEF) on the Columbus External Payload Adaptor at the International Space Station (ISS) in the period February 20 - April 28, 2008. On the Foton M2/M3 satellites relativistic electrons are observed more frequently than on the ISS because of higher (62.8°) inclination of the orbit. At both Foton satellites the usual duration of the observations are a few minutes long. On the ISS the duration usually is about 1 min or less. The places of observations of high doses due to relativistic electrons are distributed mainly at latitudes above 50° geographic latitude in both hemispheres on Foton M2/M3 satellites. A very high maximum is found in the southern hemisphere at longitudinal range 0°-60°E. At the ISS the maximums are observed between 45° and 52° geographic latitude in both hemispheres mainly at longitudes equatorward from the magnetic poles. The measured absolute maximums of dose rates generated by relativistic electrons are found to be as follows: 304 μGy h -1 behind 1.75 g cm -2 shielding at Foton M2, 2314 μGy h -1 behind 0.71 g cm -2 shielding at Foton M3 and 19,195 μGy h -1 (Flux is 8363 cm -2 s -1) behind les than 0.4 g cm -2 shielding at ISS.

  3. Selection of Electronic Resources.

    Science.gov (United States)

    Weathers, Barbara

    1998-01-01

    Discusses the impact of electronic resources on collection development; selection of CD-ROMs, (platform, speed, video and sound, networking capability, installation and maintenance); selection of laser disks; and Internet evaluation (accuracy of content, authority, objectivity, currency, technical characteristics). Lists Web sites for evaluating…

  4. Electronic Resource Management Systems

    Directory of Open Access Journals (Sweden)

    Mark Ellingsen

    2004-10-01

    Full Text Available Computer applications which deal with electronic resource management (ERM are quite a recent development. They have grown out of the need to manage the burgeoning number of electronic resources particularly electronic journals. Typically, in the early years of e-journal acquisition, library staff provided an easy means of accessing these journals by providing an alphabetical list on a web page. Some went as far as categorising the e-journals by subject and then grouping the journals either on a single web page or by using multiple pages. It didn't take long before it was recognised that it would be more efficient to dynamically generate the pages from a database rather than to continually edit the pages manually. Of course, once the descriptive metadata for an electronic journal was held within a database the next logical step was to provide administrative forms whereby that metadata could be manipulated. This in turn led to demands for incorporating more information and more functionality into the developing application.

  5. Electronic Resource Management and Design

    Science.gov (United States)

    Abrams, Kimberly R.

    2015-01-01

    We have now reached a tipping point at which electronic resources comprise more than half of academic library budgets. Because of the increasing work associated with the ever-increasing number of e-resources, there is a trend to distribute work throughout the library even in the presence of an electronic resources department. In 2013, the author…

  6. Electronic Resource Management and Design

    Science.gov (United States)

    Abrams, Kimberly R.

    2015-01-01

    We have now reached a tipping point at which electronic resources comprise more than half of academic library budgets. Because of the increasing work associated with the ever-increasing number of e-resources, there is a trend to distribute work throughout the library even in the presence of an electronic resources department. In 2013, the author…

  7. Structural and electronic properties of reduced transition metal oxide clusters, M3O8 and M3O8- (M = Cr, W), from photoelectron spectroscopy and quantum chemical calculations.

    Science.gov (United States)

    Li, Shenggang; Zhai, Hua-Jin; Wang, Lai-Sheng; Dixon, David A

    2009-10-22

    We report a comparative study of reduced transition metal oxide clusters, M(3)O(8)(-) (M = Cr, W) anions and their neutrals, via anion photoelectron spectroscopy (PES) and density functional theory (DFT) and molecular orbital theory (CCSD(T)) calculations. Well-resolved PES spectra are obtained for M(3)O(8)(-) (M = Cr, W) at 193 and 157 nm photon energies. Different PES spectra are observed for M = Cr versus M = W. Extensive DFT and CCSD(T) calculations are performed to locate the ground and low-lying excited states for the neutrals and anions. The ground states of Cr(3)O(8) and Cr(3)O(8)(-) are predicted to be the (3)B(2) and (4)B(2) states of a C(2v) structure, respectively, revealing ferromagnetic spin coupling for Cr 3d electrons. In contrast, the ground states of W(3)O(8) and W(3)O(8)(-) are predicted to be the (1)A' state (C(s) symmetry) and the (2)A(1) state (C(2v) symmetry), respectively, showing metal-metal d-d bonding in the anion. The current cluster geometries are in qualitative agreement with prior DFT studies at the PBE level for M = Cr and the B3LYP level for M = W. The BP86 and PW91 functionals significantly outperform the B3LYP functional for the Cr species, in terms of relative energies, electron detachment energies, and electronic excitation energies, whereas the B3LYP functional is better for the W species. Accurate heats of formation for the ground states of M(3)O(8) are calculated from the clustering energies and the heats of formation of MO(2) and MO(3). The energetics have been used to predict redox reaction thermochemistry.

  8. Managing electronic resources a LITA guide

    CERN Document Server

    Weir, Ryan O

    2012-01-01

    Informative, useful, current, Managing Electronic Resources: A LITA Guide shows how to successfully manage time, resources, and relationships with vendors and staff to ensure personal, professional, and institutional success.

  9. Electronic Resources Management Project Presentation 2012

    KAUST Repository

    Ramli, Rindra M.

    2012-11-05

    This presentation describes the electronic resources management project undertaken by the KAUST library. The objectives of this project is to migrate information from MS Sharepoint to Millennium ERM module. One of the advantages of this migration is to consolidate all electronic resources into a single and centralized location. This would allow for better information sharing among library staff.

  10. Implementing CORAL: An Electronic Resource Management System

    Science.gov (United States)

    Whitfield, Sharon

    2011-01-01

    A 2010 electronic resource management survey conducted by Maria Collins of North Carolina State University and Jill E. Grogg of University of Alabama Libraries found that the top six electronic resources management priorities included workflow management, communications management, license management, statistics management, administrative…

  11. Implementing CORAL: An Electronic Resource Management System

    Science.gov (United States)

    Whitfield, Sharon

    2011-01-01

    A 2010 electronic resource management survey conducted by Maria Collins of North Carolina State University and Jill E. Grogg of University of Alabama Libraries found that the top six electronic resources management priorities included workflow management, communications management, license management, statistics management, administrative…

  12. Resource Letter: TE-1: Teaching electronics

    Science.gov (United States)

    Henry, Dennis C.

    2002-01-01

    This Resource Letter examines the evolution, roles, and content of courses in electronics in the undergraduate physics curriculum, and provides a guide to resources for faculty teaching such courses. It concludes with a brief section addressing problems of electromagnetic interference in electronic systems, and provides an introduction to the literature and practice of electromagnetic compatibility. I have included textbooks, reference books, articles, collections of laboratory experiments and projects, sources of equipment and parts, software packages, videos, and websites.

  13. Electronic Resources Management System: Recommendation Report 2017

    KAUST Repository

    Ramli, Rindra M.

    2017-05-01

    This recommendation report provides an overview of the selection process for the new Electronic Resources Management System. The library has decided to move away from Innovative Interfaces Millennium ERM module. The library reviewed 3 system as potential replacements namely: Proquest 360 Resource Manager, Ex Libris Alma and Open Source CORAL ERMS. After comparing and trialling the systems, it was decided to go for Proquest 360 Resource Manager.

  14. Bonding the superalkali M3O (M = Li and K): An effective strategy to improve the electronic and nonlinear optical properties of the inorganic B40 nanocage

    Science.gov (United States)

    Li, Zhipeng; Yu, Guangtao; Zhang, Xueying; Huang, Xuri; Chen, Wei

    2017-10-01

    Inspired by the fascinating finding of all-boron fullerene B40 (Nat Chem, 2014, 6, 727), we propose a new and effective strategy to construct a series of typical Donor-Acceptor (D-A) frameworks via linking the superalkali M3O (M = Li and K) unit with the low ionization potential to the B40 nanocage with large electron affinity. By means of the density functional theory computations, we have systematically investigated the structures, electronic properties, the first and second hyperpolarizabilities of these modified B40 nanocage systems. Owing to the formation of a B-O chemical bond, these composite systems (M3O)n-B40 (M = Li and K, n = 1 and 2) can possess the considerably large binding energy ranging from 57.0 to 99.8 kcal/mol, indicating their high structure stabilities. Compared with the pristine B40 nanocage, linking the superalkali M3O can effectively narrow the wide energy gap from the original 2.86 eV to 0.61-1.11 eV, and significantly increase the first and second hyperpolarizabilities to as large as 5.00 × 104-2.46 × 105 au and 1.48 × 107-4.85 × 108 au, respectively, owing to the occurrence of evident electron transfer process in this kind of typical D-A framework. These fascinating findings will be advantageous for promoting the potential applications of the inorganic boron-based nanosystems in the new type of electronic nanodevices and high-performance nonlinear optical materials.

  15. Library Training to Promote Electronic Resource Usage

    DEFF Research Database (Denmark)

    Frandsen, Tove Faber; Tibyampansha, Dativa; Ibrahim, Glory

    2017-01-01

    Purpose: Increasing the usage of electronic resources is an issue of concern for many libraries all over the world. Several studies stress the importance of information literacy and instruction in order to increase the usage. Design/methodology/approach: The present article presents the results...

  16. Reviewing the Electronic Resources & Libraries Conference

    Science.gov (United States)

    Tijerina, Bonnie

    2008-01-01

    The third Electronic Resources & Libraries (ER&L) conference gathered at Georgia Institute of Technology's Global Learning and Conference Center in Atlanta, Georgia, March 18-21, 2008. Over 360 attendees, from six countries and from 80% of the United States, represented their libraries and organizations resulting in a diverse and…

  17. Making sense of the electronic resource marketplace: trends in health-related electronic resources.

    Science.gov (United States)

    Blansit, B D; Connor, E

    1999-07-01

    Changes in the practice of medicine and technological developments offer librarians unprecedented opportunities to select and organize electronic resources, use the Web to deliver content throughout the organization, and improve knowledge at the point of need. The confusing array of available products, access routes, and pricing plans makes it difficult to anticipate the needs of users, identify the top resources, budget effectively, make sound collection management decisions, and organize the resources effectively and seamlessly. The electronic resource marketplace requires much vigilance, considerable patience, and continuous evaluation. There are several strategies that librarians can employ to stay ahead of the electronic resource curve, including taking advantage of free trials from publishers; marketing free trials and involving users in evaluating new products; watching and testing products marketed to the clientele; agreeing to beta test new products and services; working with aggregators or republishers; joining vendor advisory boards; benchmarking institutional resources against five to eight competitors; and forming or joining a consortium for group negotiating and purchasing. This article provides a brief snapshot of leading biomedical resources; showcases several libraries that have excelled in identifying, acquiring, and organizing electronic resources; and discusses strategies and trends of potential interest to biomedical librarians, especially those working in hospital settings.

  18. Electronic resource management systems a workflow approach

    CERN Document Server

    Anderson, Elsa K

    2014-01-01

    To get to the bottom of a successful approach to Electronic Resource Management (ERM), Anderson interviewed staff at 11 institutions about their ERM implementations. Among her conclusions, presented in this issue of Library Technology Reports, is that grasping the intricacies of your workflow-analyzing each step to reveal the gaps and problems-at the beginning is crucial to selecting and implementing an ERM. Whether the system will be used to fill a gap, aggregate critical data, or replace a tedious manual process, the best solution for your library depends on factors such as your current soft

  19. Electronic Resource Management System. Vernetzung von Lizenzinformationen

    Directory of Open Access Journals (Sweden)

    Michaela Selbach

    2014-12-01

    Full Text Available In den letzten zehn Jahren spielen elektronische Ressourcen im Bereich der Erwerbung eine zunehmend wichtige Rolle: Eindeutig lässt sich hier ein Wandel in den Bibliotheken (fort vom reinen Printbestand zu immer größeren E-Only-Beständen feststellen. Die stetig wachsende Menge an E-Ressourcen und deren Heterogenität stellt Bibliotheken vor die Herausforderung, die E-Ressourcen effizient zu verwalten. Nicht nur Bibliotheken, sondern auch verhandlungsführende Institutionen von Konsortial- und Allianzlizenzen benötigen ein geeignetes Instrument zur Verwaltung von Lizenzinformationen, welches den komplexen Anforderungen moderner E-Ressourcen gerecht wird. Die Deutsche Forschungsgemeinschaft (DFG unterstützt ein Projekt des Hochschulbibliothekszentrums des Landes Nordrhein-Westfalen (hbz, der Universitätsbibliothek Freiburg, der Verbundzentrale des Gemeinsamen Bibliotheksverbundes (GBV und der Universitätsbibliothek Frankfurt, in dem ein bundesweit verfügbares Electronic Ressource Managementsystem (ERMS aufgebaut werden soll. Ein solches ERMS soll auf Basis einer zentralen Knowledge Base eine einheitliche Nutzung von Daten zur Lizenzverwaltung elektronischer Ressourcen auf lokaler, regionaler und nationaler Ebene ermöglichen. Statistische Auswertungen, Rechteverwaltung für alle angeschlossenen Bibliotheken, kooperative Datenpflege sowie ein über standardisierte Schnittstellen geführter Datenaustausch stehen bei der Erarbeitung der Anforderungen ebenso im Fokus wie die Entwicklung eines Daten- und Funktionsmodells. In the last few years the importance of electronic resources in library acquisitions has increased significantly. There has been a shift from mere print holdings to both e- and print combinations and even e-only subscriptions. This shift poses a double challenge for libraries: On the one hand they have to provide their e-resource collections to library users in an appealing way, on the other hand they have to manage these

  20. Utilization of electronic information resources by academic staff at ...

    African Journals Online (AJOL)

    Utilization of electronic information resources by academic staff at Makerere University. ... AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search ... It examined the academic staff awareness of the resources available, the types ...

  1. Effectiveness Analysis of Electronic Resources at the Hacettepe University

    OpenAIRE

    2011-01-01

    It is important to collect and analyze the usage data of electronic databases and periodicals in order to make policies regarding the composition, improvement and more extensive utilization of electronic resources of libraries. The aim of this study is to investigate how efficiently the full text accessible electronic resources of Hacettepe University Libraries are used. For this purpose the usage data obtained from COUNTER Software regarding the electronic databases to which Hacettepe Univer...

  2. The Study of Analytical Model of Library Electronic Resources Usage-A Case of Medical Electronic Resources

    OpenAIRE

    Chung-Yen Yu; Jiann-Cherng Shieh

    2014-01-01

    With the advents of internet, the importance of electronic resources is growing. Due to the increasing expensiveness of electronic resources, university libraries normally received budgets from parent institutions annually. They necessarily applied effective and systematic methods for decision making in electronic resources purchase or re-subscription. However, there are some difficulties in practices: First of all, libraries are unable to receive user records; second, the COUNTER statistics ...

  3. The Role of the Acquisitions Librarian in Electronic Resources Management

    Science.gov (United States)

    Pomerantz, Sarah B.

    2010-01-01

    With the ongoing shift to electronic formats for library resources, acquisitions librarians, like the rest of the profession, must adapt to the rapidly changing landscape of electronic resources by keeping up with trends and mastering new skills related to digital publishing, technology, and licensing. The author sought to know what roles…

  4. Electronic resources preferred by pediatric hospitalists for clinical care.

    Science.gov (United States)

    Beck, Jimmy B; Tieder, Joel S

    2015-10-01

    There is little research on pediatric hospitalists' use of evidence-based resources. The aim of this study was to determine the electronic resources that pediatric hospitalists prefer. Using a web-based survey, the authors determined hospitalists' preferred electronic resources, as well as their attitudes toward lifelong learning, practice, and experience characteristics. One hundred sixteen hospitalists completed the survey. The most preferred resource for general information, patient handouts, and treatment was UpToDate. Online search engines were ranked second for general information and patient handouts. Pediatric hospitalists tend to utilize less rigorous electronic resources such as UpToDate and Google. These results can set a platform for discussing the quality of resources that pediatric hospitalists use.

  5. Cataloging and Indexing of Electronic Information Resources

    Science.gov (United States)

    2003-04-01

    digital library, but it facilitates the exchange of these objects among digital libraries . METS provides an XML DTD that can point to metadata in other...International Federation of Library Associations and Institutions (IFLA). (2002). Digital Libraries : Metadata Resources. Retrieved May 3, 2002 from the

  6. Adoption and use of electronic information resources by medical ...

    African Journals Online (AJOL)

    ... were analysed with descriptive Statistics(Simple percentage and frequency count). ... for doing assignment, Google search, for personal development, and getting ... major problems encountered when using electronic Information Resources.

  7. Euler European Libraries and Electronic Resources in Mathematical Sciences

    CERN Document Server

    The Euler Project. Karlsruhe

    The European Libraries and Electronic Resources (EULER) Project in Mathematical Sciences provides the EulerService site for searching out "mathematical resources such as books, pre-prints, web-pages, abstracts, proceedings, serials, technical reports preprints) and NetLab (for Internet resources), this outstanding engine is capable of simple, full, and refined searches. It also offers a browse option, which responds to entries in the author, keyword, and title fields. Further information about the Project is provided at the EULER homepage.

  8. Building an electronic resource collection a practical guide

    CERN Document Server

    Lee, Stuart D

    2004-01-01

    This practical book guides information professionals step-by-step through building and managing an electronic resource collection. It outlines the range of electronic products currently available in abstracting and indexing, bibliographic, and other services and then describes how to effectively select, evaluate and purchase them.

  9. Why and How to Measure the Use of Electronic Resources

    Directory of Open Access Journals (Sweden)

    Jean Bernon

    2008-11-01

    Full Text Available A complete overview of library activity implies a complete and reliable measurement of the use of both electronic resources and printed materials. This measurement is based on three sets of definitions: document types, use types and user types. There is a common model of definitions for printed materials, but a lot of questions and technical issues remain for electronic resources. In 2006 a French national working group studied these questions. It relied on the COUNTER standard, but found it insufficient and pointed out the need for local tools such as web markers and deep analysis of proxy logs. Within the French national consortium COUPERIN, a new working group is testing ERMS, SUSHI standards, Shibboleth authentication, along with COUNTER standards, to improve the counting of the electronic resources use. At this stage this counting is insufficient and its improvement will be a European challenge for the future.

  10. Access to electronic resources by visually impaired people

    Directory of Open Access Journals (Sweden)

    Jenny Craven

    2003-01-01

    Full Text Available Research into access to electronic resources by visually impaired people undertaken by the Centre for Research in Library and Information Management has not only explored the accessibility of websites and levels of awareness in providing websites that adhere to design for all principles, but has sought to enhance understanding of information seeking behaviour of blind and visually impaired people when using digital resources.

  11. The Study of Analytical Model of Library Electronic Resources Usage-A Case of Medical Electronic Resources

    Directory of Open Access Journals (Sweden)

    Chung-Yen Yu

    2014-10-01

    Full Text Available With the advents of internet, the importance of electronic resources is growing. Due to the increasing expensiveness of electronic resources, university libraries normally received budgets from parent institutions annually. They necessarily applied effective and systematic methods for decision making in electronic resources purchase or re-subscription. However, there are some difficulties in practices: First of all, libraries are unable to receive user records; second, the COUNTER statistics does not include details about users and their affiliation. As a result, one cannot conduct advanced user analysis based on the usage of users, institutions, and departments. To overcome the difficulties, this study presents a feasible model to analyze electronic resource usage effectively and flexibly. We set up a proxy server to collect actual usage raw data. By analyzing items in internet browsing records, associated with original library automatic system, this study aims at exploring how to use effective ways to analyze big data of website log data. We also propose the process of how original data to be transformed, cleared, integrated, and demonstrated. This study adopted a medical university library and its subscription of medical electronic resources as a case. Our data analysis includes (1 year of subscription,(2 title of journal, (3 affiliation, (4 subjects, and (5 specific journal requirements, etc. The findings of the study are contributed to obtain further understanding in policy making and user behavior analysis. The integrated data provides multiple applications in informatics research, information behavior, bibliomining, presenting diverse views and extended issues for further discussion.

  12. Practical guide to electronic resources in the humanities

    CERN Document Server

    Dubnjakovic, Ana

    2010-01-01

    From full-text article databases to digitized collections of primary source materials, newly emerging electronic resources have radically impacted how research in the humanities is conducted and discovered. This book, covering high-quality, up-to-date electronic resources for the humanities, is an easy-to-use annotated guide for the librarian, student, and scholar alike. It covers online databases, indexes, archives, and many other critical tools in key humanities disciplines including philosophy, religion, languages and literature, and performing and visual arts. Succinct overviews of key eme

  13. Discipline, availability of electronic resources and the use of Finnish National Electronic Library - FinELib

    Directory of Open Access Journals (Sweden)

    Sanna Torma

    2004-01-01

    Full Text Available This study elaborated relations between digital library use by university faculty, users' discipline and the availability of key resources in the Finnish National Electronic Library (FinELib, Finnish national digital library, by using nationwide representative survey data. The results show that the perceived availability of key electronic resources by researchers in FinELib was a stronger predictor of the frequency and purpose of use of its services than users' discipline. Regardless of discipline a good perceived provision of central resources led to a more frequent use of FinELib. The satisfaction with the services did not vary with the discipline, but with the perceived availability of resources.

  14. Providing Access to Electronic Information Resources in Further Education

    Science.gov (United States)

    Banwell, Linda; Ray, Kathryn; Coulson, Graham; Urquhart, Christine; Lonsdale, Ray; Armstrong, Chris; Thomas, Rhian; Spink, Sin; Yeoman, Alison; Fenton, Roger; Rowley, Jennifer

    2004-01-01

    This article aims to provide a baseline for future studies on the provision and support for the use of digital or electronic information services (EIS) in further education. The analysis presented is based on a multi-level model of access, which encompasses access to and availability of information and communication technology (ICT) resources,…

  15. ANALYTICAL REVIEW OF ELECTRONIC RESOURCES FOR THE STUDY OF LATIN

    Directory of Open Access Journals (Sweden)

    Olena Yu. Balalaieva

    2014-04-01

    Full Text Available The article investigates the current state of development of e-learning content in the Latin language. It is noted that the introduction of ICT in the educational space has expanded the possibility of studying Latin, opened access to digital libraries resources, made it possible to use scientific and educational potential and teaching Latin best practices of world's leading universities. A review of foreign and Ukrainian information resources and electronic editions for the study of Latin is given. Much attention was paid to the didactic potential of local and online multimedia courses of Latin, electronic textbooks, workbooks of interactive tests and exercises, various dictionaries and software translators, databases and digital libraries. Based on analysis of the world market of educational services and products the main trends in the development of information resources and electronic books are examined. It was found that multimedia courses with interactive exercises or workbooks with interactive tests, online dictionaries and translators are the most widely represented and demanded. The noticeable lagging of Ukrainian education and computer linguistics in quantitative and qualitative measures in this industry is established. The obvious drawback of existing Ukrainian resources and electronic editions for the study of Latin is their noninteractive nature. The prospects of e-learning content in Latin in Ukraine are outlined.

  16. Electronic Commerce Resource Centers. An Industry--University Partnership.

    Science.gov (United States)

    Gulledge, Thomas R.; Sommer, Rainer; Tarimcilar, M. Murat

    1999-01-01

    Electronic Commerce Resource Centers focus on transferring emerging technologies to small businesses through university/industry partnerships. Successful implementation hinges on a strategic operating plan, creation of measurable value for customers, investment in customer-targeted training, and measurement of performance outputs. (SK)

  17. Student Satisfaction with Electronic Library Resources at Wayne State University

    Science.gov (United States)

    Holley, Robert P.; Powell, Ronald R.

    2004-01-01

    This paper reports the results of a survey of student satisfaction with electronic library resources other than the online catalog at Wayne State University. Undertaken in Fall Term 2000 as a class project for a marketing course, a student team designed, administered, and analyzed a survey of a random sample of students. Almost 40% of the…

  18. Electronic Commerce Resource Centers. An Industry--University Partnership.

    Science.gov (United States)

    Gulledge, Thomas R.; Sommer, Rainer; Tarimcilar, M. Murat

    1999-01-01

    Electronic Commerce Resource Centers focus on transferring emerging technologies to small businesses through university/industry partnerships. Successful implementation hinges on a strategic operating plan, creation of measurable value for customers, investment in customer-targeted training, and measurement of performance outputs. (SK)

  19. Technical Communicator: A New Model for the Electronic Resources Librarian?

    Science.gov (United States)

    Hulseberg, Anna

    2016-01-01

    This article explores whether technical communicator is a useful model for electronic resources (ER) librarians. The fields of ER librarianship and technical communication (TC) originated and continue to develop in relation to evolving technologies. A review of the literature reveals four common themes for ER librarianship and TC. While the…

  20. Providing Access to Electronic Information Resources in Further Education

    Science.gov (United States)

    Banwell, Linda; Ray, Kathryn; Coulson, Graham; Urquhart, Christine; Lonsdale, Ray; Armstrong, Chris; Thomas, Rhian; Spink, Sin; Yeoman, Alison; Fenton, Roger; Rowley, Jennifer

    2004-01-01

    This article aims to provide a baseline for future studies on the provision and support for the use of digital or electronic information services (EIS) in further education. The analysis presented is based on a multi-level model of access, which encompasses access to and availability of information and communication technology (ICT) resources,…

  1. Theoretical study of the structure, bonding and electronic behaviour of sandwich complexes [M3(C7H7)2X3]- (M = Ni, Pd, Pt; X = F, Cl)

    Science.gov (United States)

    Zhou, Ke; Min, Suotian; Xue, Ganglin; Huang, Wendeng

    2014-08-01

    The correlations between the structural and electronic properties of the clusters [M3X3]3- and sandwich complexes [M3(C7H7)2X3]- (where M = Ni, Pd, Pt; X = F, Cl) were studied with density functional theory (B3PW91). All of the sandwich complexes are donating and back-donating metal-ligand bonding structures. The influence of the ligand, significant variations in the Msbnd C, Msbnd X, Msbnd M, Csbnd C bond lengths and binding energies were examined to obtain qualitative and quantitative pictures of the intramolecular C7R7+-M3X33- interactions. Our theoretical investigations show that the binding energies of the sandwich complexes gradually reduce from Ni to Pt, as well as from F to Cl. Meanwhile, the geometric and electronic structures and the relative stabilities have a strong relation to each other. S1). 7-B-(H-10) is a delocalised σ orbital, which has contributions from Pt (15% s orbital of each Pt, 8% d orbital of each Pt), and there is little contribution from Cl (Table S2). 7-C-(H-11) is a delocalised π orbital, which mainly involves contribution from Pt (25% dxz and dyz of each Pt) and Cl (8.5% pz of each Cl) (Table S3). 7-D-(H-14) is a delocalised σ orbital, which is mostly composed of d orbitals (14% for each Pt) and p orbitals (16% for each Cl) (Table S4). Pt s (10%) and d (10%) orbitals mainly participate in the formations of 7-E-(H-23), and there is a 13% p orbital contribution from each Cl (Table S5). For structure 13, the LUMO is mainly s orbitals of C, and there is some contribution from the s and d orbitals of Pt (Table S6), whereas the HOMO is mainly s orbitals of C (Table S7). 13-c-(H-14) is mainly the dxz and dyz orbitals of Pt (Table S8).NICS can be used to predict and understand some of the properties of a molecule, especially its stability due to aromatic stabilisation, which is based on the negative of the magnetic shielding computed at or above the geometrical centres of rings or clusters. Systems with negative NICS values are aromatic

  2. Evaluating the appropriateness of electronic information resources for learning.

    Science.gov (United States)

    Saparova, Dinara; Nolan, Nathanial S

    2016-01-01

    Current US medical students have begun to rely on electronic information repositories-such as UpToDate, AccessMedicine, and Wikipedia-for their pre-clerkship medical education. However, it is unclear whether these resources are appropriate for this level of learning due to factors involving information quality, level of evidence, and the requisite knowledgebase. This study evaluated appropriateness of electronic information resources from a novel perspective: amount of mental effort learners invest in interactions with these resources and effects of the experienced mental effort on learning. Eighteen first-year medical students read about three unstudied diseases in the above-mentioned resources (a total of fifty-four observations). Their eye movement characteristics (i.e., fixation duration, fixation count, visit duration, and task-evoked pupillary response) were recorded and used as psychophysiological indicators of the experienced mental effort. Post reading, students' learning was assessed with multiple-choice tests. Eye metrics and test results constituted quantitative data analyzed according to the repeated Latin square design. Students' perceptions of interacting with the information resources were also collected. Participants' feedback during semi-structured interviews constituted qualitative data and was reviewed, transcribed, and open coded for emergent themes. Compared to AccessMedicine and Wikipedia, UpToDate was associated with significantly higher values of eye metrics, suggesting learners experienced higher mental effort. No statistically significant difference between the amount of mental effort and learning outcomes was found. More so, descriptive statistical analysis of the knowledge test scores suggested similar levels of learning regardless of the information resource used. Judging by the learning outcomes, all three information resources were found appropriate for learning. UpToDate, however, when used alone, may be less appropriate for first

  3. Electronic and spin-orbit properties of the kagome MOF family M3(1,2,5,6,9, 10-triphenylenehexathiol)2 (M  =  Ni, Pt, Cu and Au).

    Science.gov (United States)

    Silveira, Orlando J; Chacham, Helio

    2017-03-08

    We investigate, through first-principles calculations, the electronic band structure-including the spin-orbit coupling-of single-layer M3(THT)2 metal-organic frameworks, where M  =  Ni, Pt, Cu and Au, and THT is the 1,2,5,6,9,10-triphenylenehexathiol molecule. This MOF family contains, in its electronic structure, spin-orbit gaps that could allow their use in quantum spin Hall effect devices. We find that the partial inclusion of exact exchange in the calculations (beyond a semi-local exchange-correlation level) leads to quantitative, and even qualitative, modifications of the electronic structure of Ni3(THT)2 and Pt3(THT)2 relative to calculations at semi-local exchange-correlation level: upon inclusion of exact exchange, the predicted fundamental band gap of these semiconductor materials increases to more than twice, and the predicted spin-orbit gaps change by as much as 44%. Even the qualitative description of the valence bands of these materials changes upon inclusion of exact exchange. We also find that the magnitudes of the spin-orbit gaps are not monotonic with the atomic number of the metal atom.

  4. Electronic and spin–orbit properties of the kagome MOF family M3(1,2,5,6,9, 10-triphenylenehexathiol)2 (M  =  Ni, Pt, Cu and Au)

    Science.gov (United States)

    Silveira, Orlando J.; Chacham, Helio

    2017-03-01

    We investigate, through first-principles calculations, the electronic band structure—including the spin–orbit coupling—of single-layer M3(THT)2 metal-organic frameworks, where M  =  Ni, Pt, Cu and Au, and THT is the 1,2,5,6,9,10-triphenylenehexathiol molecule. This MOF family contains, in its electronic structure, spin–orbit gaps that could allow their use in quantum spin Hall effect devices. We find that the partial inclusion of exact exchange in the calculations (beyond a semi-local exchange-correlation level) leads to quantitative, and even qualitative, modifications of the electronic structure of Ni3(THT)2 and Pt3(THT)2 relative to calculations at semi-local exchange-correlation level: upon inclusion of exact exchange, the predicted fundamental band gap of these semiconductor materials increases to more than twice, and the predicted spin–orbit gaps change by as much as 44%. Even the qualitative description of the valence bands of these materials changes upon inclusion of exact exchange. We also find that the magnitudes of the spin–orbit gaps are not monotonic with the atomic number of the metal atom.

  5. MODEL OF AN ELECTRONIC EDUCATIONAL RESOURCE OF NEW GENERATION

    Directory of Open Access Journals (Sweden)

    Anatoliy V. Loban

    2016-01-01

    Full Text Available The mathematical structure of the modular architecture of an electronic educational resource (EER of new generation, which allows to decompose the process of studying the subjects of the course at a hierarchically ordered set of data (knowledge and procedures for manipulating them, to determine the roles of participants of process of training of and technology the development and use of EOR in the study procrate.

  6. A transmission electron microscopy study of radiation damages to β-dicalcium (Ca{sub 2}SiO{sub 4}) and M3-tricalcium (Ca{sub 3}SiO{sub 5}) orthosilicates

    Energy Technology Data Exchange (ETDEWEB)

    Noirfontaine, Marie-Noëlle de; Dunstetter, Frédéric [Laboratoire des Solides Irradiés, Ecole Polytechnique, CNRS UMR 7642, CEA-DSM-IRAMIS, Université Paris Saclay, F-91128 Palaiseau Cedex (France); Courtial, Mireille [Laboratoire des Solides Irradiés, Ecole Polytechnique, CNRS UMR 7642, CEA-DSM-IRAMIS, Université Paris Saclay, F-91128 Palaiseau Cedex (France); Université d' Artois, 1230 Rue de l' Université, CS 20819, F-62408 Béthune (France); Signes-Frehel, Marcel [Laboratoire des Solides Irradiés, Ecole Polytechnique, CNRS UMR 7642, CEA-DSM-IRAMIS, Université Paris Saclay, F-91128 Palaiseau Cedex (France); Wang, Guillaume [Laboratoire Matériaux et Phénomènes Quantiques, CNRS UMR 7162, Université Paris Diderot, F-75205 Paris Cedex 13 (France); Gorse-Pomonti, Dominique, E-mail: dominique.gorse-pomonti@polytechnique.edu [Laboratoire des Solides Irradiés, Ecole Polytechnique, CNRS UMR 7642, CEA-DSM-IRAMIS, Université Paris Saclay, F-91128 Palaiseau Cedex (France)

    2016-01-15

    In this paper, we present results of a first study of electron radiation damages to β-dicalcium silicate (Ca{sub 2}SiO{sub 4}:C{sub 2}S) and M3-tricalcium silicate (Ca{sub 3}SiO{sub 5}:C{sub 3}S) in a Transmission Electron Microscope. Electron irradiation is used here as a means to bring to light a difference of reactivity under the electron beam between these two complex ceramic oxides, keeping in mind that C{sub 3}S reacts faster with water than C{sub 2}S and that this property remains unexplained, owing to the complex structural characteristics of these ceramics which have not yet been fully elucidated. The following results were obtained by coupling TEM imaging and EDS analysis: i) Rapid decomposition of both silicate particles into CaO nano-crystals separated by (presumably SiO{sub 2}-rich) amorphous areas at low flux for both silicates; ii) once reached a threshold electron flux, formation of an amorphous crater in both silicates, fully calcium-depleted in C{sub 3}S but never in C{sub 2}S; iii) significant post-mortem structural evolution of the craters that at least partially recrystallize in C{sub 2}S, to be compared to the quasi frozen damaged area in C{sub 3}S; iv) hole drilling at high flux but only in C{sub 3}S once reached a threshold flux, ϕ{sub th} ∼ 7.9 × 10{sup 21} e{sup −} cm{sup −2} s{sup −1}, of the same order of magnitude than previously estimated in a number of ceramic materials, whereas C{sub 2}S still amorphizes under the electron beam for a flux as high as 2.2 × 10{sup 22} e{sup −} cm{sup −2} s{sup −1}. The radiation damages and their post–mortem evolution differ largely between C{sub 2}S and C{sub 3}S. We attempted to relate the obtained results, and especially the evolution of the Ca content in the damaged areas under the electron beam to the available structural characteristics of these two orthosilicates. - Highlights: • TEM study of electron damages in β-dicalcium (C{sub 2}S), M3-tricalcium silicates

  7. Evaluating increased resource use in fibromyalgia using electronic health records

    Directory of Open Access Journals (Sweden)

    Margolis JM

    2016-11-01

    Full Text Available Jay M Margolis,1 Elizabeth T Masters,2 Joseph C Cappelleri,3 David M Smith,1 Steven Faulkner4 1Truven Health Analytics, Life Sciences, Outcomes Research, Bethesda, MD, 2Pfizer Inc, Outcomes & Evidence, New York, NY, 3Pfizer Inc, Statistics, Groton, CT, 4Pfizer Inc, North American Medical Affairs, Medical Outcomes Specialists, St Louis, MO, USA Objective: The management of fibromyalgia (FM, a chronic musculoskeletal disease, remains challenging, and patients with FM are often characterized by high health care resource utilization. This study sought to explore potential drivers of all-cause health care resource utilization and other factors associated with high resource use, using a large electronic health records (EHR database to explore data from patients diagnosed with FM. Methods: This was a retrospective analysis of de-identified EHR data from the Humedica database. Adults (≥18 years with FM were identified based on ≥2 International Classification of Diseases, Ninth Revision codes for FM (729.1 ≥30 days apart between January 1, 2008 and December 31, 2012 and were required to have evidence of ≥12 months continuous care pre- and post-index; first FM diagnosis was the index event; 12-month pre- and post-index reporting periods. Multivariable analysis evaluated relationships between variables and resource utilization. Results: Patients were predominantly female (81.4%, Caucasian (87.7%, with a mean (standard deviation age of 54.4 (14.8 years. The highest health care resource utilization was observed for the categories of “medication orders” and “physician office visits,” with 12-month post-index means of 21.2 (21.5 drug orders/patient and 15.1 (18.1 office visits/patient; the latter accounted for 73.3% of all health care visits. Opioids were the most common prescription medication, 44.3% of all patients. The chance of high resource use was significantly increased (P<0.001 26% among African-Americans vs Caucasians and for patients

  8. Online Electronic Resources and Slovenian Bibliography: a Case Study

    Directory of Open Access Journals (Sweden)

    Daniela Škerget

    2014-09-01

    Full Text Available AbstractConsidering the fact that the number of publications available online only is growing, the question whether to include online electronic resources into the Slovenian bibliography, and if so, in which way, and what are the requirements for the inclusion, is raised. To answer these questions, the research on the growth of the Slovenian online scientific production in comparison with production in printed form was conducted in the case of original scientific articles. Results showed a rapid growth of the number of original scientific articles available online only, which indicates the necessity to form a separate Slovenian bibliography of online resources. The selection criteria for the Slovenian bibliography of online resources are also presented. This kind of bibliography would, along with the informational value, add to the historical value of intellectual production in a given time frame, enriched with a link to the resource preserved in another location (archive, repository, in case of unavailability of the resource on its original location.

  9. Journals, Data and Abstracts Make an Integrated Electronic Resource

    Science.gov (United States)

    Boyce, P.

    1996-12-01

    Astronomy now has an integrated, Web-based information resource for research papers, data and bibliographic information. The major scholarly research journals, a comprehensive abstract service and the astronomical data centers are now linked together to provide an information resource which is not available to most other scientific disciplines. As of January, 1997, the Astrophysical Journal joins the ApJ Letters on the Web. Astronomy and Astrophysics Supplements now has a page image version. Elsevier's electronic journal New Astronomy has recently made its appearance. Over forty percent of the new peer-reviewed, astronomical literature is now available electronically. The main Astronomy and Astrophysics journal, the Astronomical Journal and others will be available by 1998, at which point ninety percent of the literature will be available electronically, a figure not approached by any other scientific discipline. With so many different sources, one of the challenges has been to integrate the on-line, peer-reviewed literature into a resource which serves the astronomical community in a unified and coherent manner. Following the lead of the AAS, the major publishers have chosen to rely upon the NASA-supported Astrophysics Data System (ADS) and the astronomical data centers to provide the means by which the various separate journals can interoperate. The data centers and the ADS have developed unique identification codes for journal articles. By adopting the existing standard "bibcodes" and integrating them into their WWW links, each of the major astronomical journals are able to link to the abstracts of most of the referenced articles. Since the ADS also serves as an on-line repository for page images of the past twenty years of the major astronomical journals, the full text of many of the referenced articles are available, too. The articles in the ADS have recently been linked through their references, both forward and backward in time. With the "bibcode" providing

  10. Analysis of Human Resources Management Strategy in China Electronic Commerce Enterprises

    Science.gov (United States)

    Shao, Fang

    The paper discussed electronic-commerce's influence on enterprise human resources management, proposed and proved the human resources management strategy which electronic commerce enterprise should adopt from recruitment strategy to training strategy, keeping talent strategy and other ways.

  11. Resources

    Science.gov (United States)

    ... resources Alzheimer's - resources Anorexia nervosa - resources Arthritis - resources Asthma and allergy - resources Autism - resources Blindness - resources BPH - resources Breastfeeding - resources Bulimia - resources Burns - resources Cancer - resources Cerebral ...

  12. Discipline, Availability of Electronic Resources and the Use of Finnish National Electronic Library-- FinELib

    Science.gov (United States)

    Törmä, Sanna; Vakkari, Pertti

    2004-01-01

    This study elaborated relations between digital library use by university faculty, users' discipline and the availability of key resources in the Finnish National Electronic Library (FinELib), Finnish national digital library, by using nationwide representative survey data. The results show that the perceived availability of key electronic…

  13. End-of-life resource recovery from emerging electronic products

    DEFF Research Database (Denmark)

    Parajuly, Keshav; Habib, Komal; Cimpan, Ciprian

    2016-01-01

    of emerging electronic product, in order to understand the recovery fate of different materials and its linkage to product design. Ten different brands of RVC were dismantled and their material composition and design profiles were studied. Another 125 RVCs (349 kg) were used for an experimental trial......Integrating product design with appropriate end-of-life (EoL) processing is widely recognized to have huge potentials in improving resource recovery from electronic products. In this study, we investigate both the product characteristics and EoL processing of robotic vacuum cleaner (RVC), as a case...... at a conventional ‘shred-and-separate’ type preprocessing plant in Denmark. A detailed material flow analysis was performed throughout the recycling chain. The results show a mismatch between product design and EoL processing, and the lack of practical implementation of ‘Design for EoL’ thinking. In the best...

  14. Electronic Resources and Mission Creep: Reorganizing the Library for the Twenty-First Century

    Science.gov (United States)

    Stachokas, George

    2009-01-01

    The position of electronic resources librarian was created to serve as a specialist in the negotiation of license agreements for electronic resources, but mission creep has added more functions to the routine work of electronic resources such as cataloging, gathering information for collection development, and technical support. As electronic…

  15. Effects of Electronic Information Resources Skills Training for Lecturers on Pedagogical Practices and Research Productivity

    Science.gov (United States)

    Bhukuvhani, Crispen; Chiparausha, Blessing; Zuvalinyenga, Dorcas

    2012-01-01

    Lecturers use various electronic resources at different frequencies. The university library's information literacy skills workshops and seminars are the main sources of knowledge of accessing electronic resources. The use of electronic resources can be said to have positively affected lecturers' pedagogical practices and their work in general. The…

  16. Electronic Document Management: A Human Resource Management Case Study

    Directory of Open Access Journals (Sweden)

    Thomas Groenewald

    2004-11-01

    Full Text Available This case study serve as exemplar regarding what can go wrong with the implementation of an electronic document management system. Knowledge agility and knowledge as capital, is outlined against the backdrop of the information society and knowledge economy. The importance of electronic document management and control is sketched thereafter. The literature review is concluded with the impact of human resource management on knowledge agility, which includes references to the learning organisation and complexity theory. The intervention methodology, comprising three phases, follows next. The results of the three phases are presented thereafter. Partial success has been achieved with improving the human efficacy of electronic document management, however the client opted to discontinue the system in use. Opsomming Die gevalle studie dien as voorbeeld van wat kan verkeerd loop met die implementering van ’n elektroniese dokumentbestuur sisteem. Teen die agtergrond van die inligtingsgemeenskap en kennishuishouding word kennissoepelheid en kennis as kapitaal bespreek. Die literatuurstudie word afgesluit met die inpak van menslikehulpbronbestuur op kennissoepelheid, wat ook die verwysings na die leerorganisasie en kompleksietydsteorie insluit. Die metodologie van die intervensie, wat uit drie fases bestaan, volg daarna. Die resultate van die drie fases word vervolgens aangebied. Slegs gedeelte welslae is behaal met die verbetering van die menslike doeltreffendheid ten opsigte van elektroniese dokumentbestuur. Die klient besluit egter om nie voort te gaan om die huidige sisteem te gebruik nie.

  17. New acceptor-bridge-donor strategy for enhancing NLO response with long-range excess electron transfer from the NH2...M/M3O donor (M = Li, Na, K) to inside the electron hole cage C20F19 acceptor through the unusual σ chain bridge (CH2)4.

    Science.gov (United States)

    Bai, Yang; Zhou, Zhong-Jun; Wang, Jia-Jun; Li, Ying; Wu, Di; Chen, Wei; Li, Zhi-Ru; Sun, Chia-Chung

    2013-04-01

    Using the strong electron hole cage C20F19 acceptor, the NH2...M/M3O (M = Li, Na, and K) complicated donors with excess electron, and the unusual σ chain (CH2)4 bridge, we construct a new kind of electride molecular salt e(-)@C20F19-(CH2)4-NH2...M(+)/M3O(+) (M = Li, Na, and K) with excess electron anion inside the hole cage (to be encapsulated excess electron-hole pair) serving as a new A-B-D strategy for enhancing nonlinear optical (NLO) response. An interesting push-pull mechanism of excess electron generation and its long-range transfer is exhibited. The excess electron is pushed out from the (super)alkali atom M/M3O by the lone pair of NH2 in the donor and further pulled inside the hole cage C20F19 acceptor through the efficient long σ chain (CH2)4 bridge. Owing to the long-range electron transfer, the new designed electride molecular salts with the excess electron-hole pair exhibit large NLO response. For the e(-)@C20F19-(CH2)4-NH2...Na(+), its large first hyperpolarizability (β0) reaches up to 9.5 × 10(6) au, which is about 2.4 × 10(4) times the 400 au for the relative e(-)@C20F20...Na(+) without the extended chain (CH2)4-NH2. It is shown that the new strategy is considerably efficient in enhancing the NLO response for the salts. In addition, the effects of different bridges and alkali atomic number on β0 are also exhibited. Further, three modulating factors are found for enhancing NLO response. They are the σ chain bridge, bridge-end group with lone pair, and (super)alkali atom. The new knowledge may be significant for designing new NLO materials and electronic devices with electrons inside the cages. They may also be the basis of establishing potential organic chemistry with electron-hole pair.

  18. Electronic Safety Resource Tools -- Supporting Hydrogen and Fuel Cell Commercialization

    Energy Technology Data Exchange (ETDEWEB)

    Barilo, Nick F.

    2014-09-29

    The Pacific Northwest National Laboratory (PNNL) Hydrogen Safety Program conducted a planning session in Los Angeles, CA on April 1, 2014 to consider what electronic safety tools would benefit the next phase of hydrogen and fuel cell commercialization. A diverse, 20-person team led by an experienced facilitator considered the question as it applied to the eight most relevant user groups. The results and subsequent evaluation activities revealed several possible resource tools that could greatly benefit users. The tool identified as having the greatest potential for impact is a hydrogen safety portal, which can be the central location for integrating and disseminating safety information (including most of the tools identified in this report). Such a tool can provide credible and reliable information from a trustworthy source. Other impactful tools identified include a codes and standards wizard to guide users through a series of questions relating to application and specific features of the requirements; a scenario-based virtual reality training for first responders; peer networking tools to bring users from focused groups together to discuss and collaborate on hydrogen safety issues; and a focused tool for training inspectors. Table ES.1 provides results of the planning session, including proposed new tools and changes to existing tools.

  19. Controlling user access to electronic resources without password

    Science.gov (United States)

    Smith, Fred Hewitt

    2015-06-16

    Described herein are devices and techniques for remotely controlling user access to a restricted computer resource. The process includes pre-determining an association of the restricted computer resource and computer-resource-proximal environmental information. Indicia of user-proximal environmental information are received from a user requesting access to the restricted computer resource. Received indicia of user-proximal environmental information are compared to associated computer-resource-proximal environmental information. User access to the restricted computer resource is selectively granted responsive to a favorable comparison in which the user-proximal environmental information is sufficiently similar to the computer-resource proximal environmental information. In at least some embodiments, the process further includes comparing user-supplied biometric measure and comparing it with a predetermined association of at least one biometric measure of an authorized user. Access to the restricted computer resource is granted in response to a favorable comparison.

  20. The Internet School of Medicine: use of electronic resources by medical trainees and the reliability of those resources.

    Science.gov (United States)

    Egle, Jonathan P; Smeenge, David M; Kassem, Kamal M; Mittal, Vijay K

    2015-01-01

    Electronic sources of medical information are plentiful, and numerous studies have demonstrated the use of the Internet by patients and the variable reliability of these sources. Studies have investigated neither the use of web-based resources by residents, nor the reliability of the information available on these websites. A web-based survey was distributed to surgical residents in Michigan and third- and fourth-year medical students at an American allopathic and osteopathic medical school and a Caribbean allopathic school regarding their preferred sources of medical information in various situations. A set of 254 queries simulating those faced by medical trainees on rounds, on a written examination, or during patient care was developed. The top 5 electronic resources cited by the trainees were evaluated for their ability to answer these questions accurately, using standard textbooks as the point of reference. The respondents reported a wide variety of overall preferred resources. Most of the 73 responding medical trainees favored textbooks or board review books for prolonged studying, but electronic resources are frequently used for quick studying, clinical decision-making questions, and medication queries. The most commonly used electronic resources were UpToDate, Google, Medscape, Wikipedia, and Epocrates. UpToDate and Epocrates had the highest percentage of correct answers (47%) and Wikipedia had the lowest (26%). Epocrates also had the highest percentage of wrong answers (30%), whereas Google had the lowest percentage (18%). All resources had a significant number of questions that they were unable to answer. Though hardcopy books have not been completely replaced by electronic resources, more than half of medical students and nearly half of residents prefer web-based sources of information. For quick questions and studying, both groups prefer Internet sources. However, the most commonly used electronic resources fail to answer clinical queries more than half

  1. Developing Humanities Collections in the Digital Age: Exploring Humanities Faculty Engagement with Electronic and Print Resources

    Science.gov (United States)

    Kachaluba, Sarah Buck; Brady, Jessica Evans; Critten, Jessica

    2014-01-01

    This article is based on quantitative and qualitative research examining humanities scholars' understandings of the advantages and disadvantages of print versus electronic information resources. It explores how humanities' faculty members at Florida State University (FSU) use print and electronic resources, as well as how they perceive these…

  2. Developing Humanities Collections in the Digital Age: Exploring Humanities Faculty Engagement with Electronic and Print Resources

    Science.gov (United States)

    Kachaluba, Sarah Buck; Brady, Jessica Evans; Critten, Jessica

    2014-01-01

    This article is based on quantitative and qualitative research examining humanities scholars' understandings of the advantages and disadvantages of print versus electronic information resources. It explores how humanities' faculty members at Florida State University (FSU) use print and electronic resources, as well as how they perceive these…

  3. Electronic resource management practical perspectives in a new technical services model

    CERN Document Server

    Elguindi, Anne

    2012-01-01

    A significant shift is taking place in libraries, with the purchase of e-resources accounting for the bulk of materials spending. Electronic Resource Management makes the case that technical services workflows need to make a corresponding shift toward e-centric models and highlights the increasing variety of e-formats that are forcing new developments in the field.Six chapters cover key topics, including: technical services models, both past and emerging; staffing and workflow in electronic resource management; implementation and transformation of electronic resource management systems; the ro

  4. Strategic Planning for Electronic Resources Management: A Case Study at Gustavus Adolphus College

    Science.gov (United States)

    Hulseberg, Anna; Monson, Sarah

    2009-01-01

    Electronic resources, the tools we use to manage them, and the needs and expectations of our users are constantly evolving; at the same time, the roles, responsibilities, and workflow of the library staff who manage e-resources are also in flux. Recognizing a need to be more intentional and proactive about how we manage e-resources, the…

  5. Strategic Planning for Electronic Resources Management: A Case Study at Gustavus Adolphus College

    Science.gov (United States)

    Hulseberg, Anna; Monson, Sarah

    2009-01-01

    Electronic resources, the tools we use to manage them, and the needs and expectations of our users are constantly evolving; at the same time, the roles, responsibilities, and workflow of the library staff who manage e-resources are also in flux. Recognizing a need to be more intentional and proactive about how we manage e-resources, the…

  6. The Relevancy of Graduate Curriculum to Human Resource Professionals' Electronic Communication.

    Science.gov (United States)

    Hoell, Robert C.; Henry, Gordon O.

    2003-01-01

    Electronic communications of human resource professionals and the content of 23 university human resource management courses were categorized using the Human Resource Certification Institute's body of knowledge. Differences between proportion of topics discussed and topics covered in curricula suggest some topics are over- or undertaught.…

  7. 2015 Utilization of Electronic Information Resources in Ramat ...

    African Journals Online (AJOL)

    intensely powerful and has permeated all segments and ... Web (WWW) and the internet to make information more accessible. On the other ... access points on the campus and computer literacy is till .... resources are often faster to consult than.

  8. Remote Electronic Resources and the OPAC: Illustrated by the Unisa Library Experience.

    Science.gov (United States)

    Van der Merwe, Ina; Van Eeden, Welna; Hartzer, Sandra

    This paper describes the Unisa (University of South Africa) Library's experience with cataloging remote electronic resources, including electronic journals, electronic text files, online databases, digital images, Unisa campus Web sites, and mailing list discussions. The first section discusses the decision to add bibliographic references for…

  9. Controlling user access to electronic resources without password

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Fred Hewitt

    2017-08-22

    Described herein are devices and techniques for remotely controlling user access to a restricted computer resource. The process includes obtaining an image from a communication device of a user. An individual and a landmark are identified within the image. Determinations are made that the individual is the user and that the landmark is a predetermined landmark. Access to a restricted computing resource is granted based on the determining that the individual is the user and that the landmark is the predetermined landmark. Other embodiments are disclosed.

  10. An Evaluation of Electronic Product Design Education Using Hypermedia-Resourced Learning Environments

    Science.gov (United States)

    Page, Tom; Thorsteinsson, Gisli

    2006-01-01

    The work outlined here provides a comprehensive report and formative observations of the development and implementation of hypermedia resources for learning and teaching used in conjunction with a managed learning environment (MLE). These resources are used to enhance teaching and learning of an electronics module in product design at final year…

  11. A Study on Developing Evaluation Criteria for Electronic Resources in Evaluation Indicators of Libraries

    Science.gov (United States)

    Noh, Younghee

    2010-01-01

    This study aimed to improve the current state of electronic resource evaluation in libraries. While the use of Web DB, e-book, e-journal, and other e-resources such as CD-ROM, DVD, and micro materials is increasing in libraries, their use is not comprehensively factored into the general evaluation of libraries and may diminish the reliability of…

  12. Managing Selection for Electronic Resources: Kent State University Develops a New System to Automate Selection

    Science.gov (United States)

    Downey, Kay

    2012-01-01

    Kent State University has developed a centralized system that manages the communication and work related to the review and selection of commercially available electronic resources. It is an automated system that tracks the review process, provides selectors with price and trial information, and compiles reviewers' feedback about the resource. It…

  13. Where Do Electronic Books Fit in the College Research Arsenal of Resources?

    Science.gov (United States)

    Barbier, Patricia

    2007-01-01

    Student use of electronic books has become an accepted supplement to traditional resources. Student use and satisfaction was monitored through an online course discussion board. Increased use of electronic books indicate this service is an accepted supplement to the print book collection.

  14. Where Do Electronic Books Fit in the College Research Arsenal of Resources?

    Science.gov (United States)

    Barbier, Patricia

    2007-01-01

    Student use of electronic books has become an accepted supplement to traditional resources. Student use and satisfaction was monitored through an online course discussion board. Increased use of electronic books indicate this service is an accepted supplement to the print book collection.

  15. MULER: Building an Electronic Resource Management (ERM Solution at York University

    Directory of Open Access Journals (Sweden)

    Aaron August Lupton

    2012-01-01

    Full Text Available Many university libraries now utilize an Electronic Resource Management (ERM system to assist with operations related to electronic resources. An ERM is a relational database containing information such as suppliers, costs, holdings, and renewal dates for electronic resources, both at the database and title levels. While commercial ERM products are widely available, some institutions are custom building their own ERM in- house. This article describes how York University in Toronto, Canada, did just that by building a system called Managing University Library Electronic Resources (MULER. The article details the background and history of how electronic resources were managed pre-MULER; why a new ERM was needed; the planning process; the current and innovative functions of MULER, including integration of MULER data into York University Libraries search and discovery layer, Vufind; subject tagging in MULER; new functions to be added; and lessons learned from the project. Positive and negative implications of choosing an in-house project over paying for a commercial product are also discussed.

  16. The National Site Licensing of Electronic Resources: An Institutional Perspective

    Directory of Open Access Journals (Sweden)

    Xiaohua Zhu

    2011-06-01

    Full Text Available While academic libraries in most countries are struggling to negotiate with publishers and vendors individually or collaboratively via consortia, a few countries have experimented with a different model, national site licensing (NSL. Because NSL often involves government and large-scale collaboration, it has the potential to solve many problems in the complex licensing world. However, not many nations have adopted it. This study uses historical research approach and the comparative case study research method to explore the seemingly low level of adoption. The cases include the Canadian National Site Licensing Project (CNSLP, the United Kingdom’s National Electronic Site Licensing Initiative (NESLI, and the United States, which has not adopted NSL. The theoretical framework guiding the research design and data collection is W. Richard Scott’s institutional theory, which utilizes three supporting pillars—regulative, normative, and cultural-cognitive—to analyze institutional processes. In this study, the regulative pillar and the normative pillar of NSL adoption— an institutional construction and change—are examined. Data were collected from monographs, research articles, government documents, and relevant websites. Based on the analysis of these cases, a preliminary model is proposed for the adoption of NSL. The factors that support a country’s adoption of NSL include the need for new institutions, a centralized educational policy-making system and funding system, supportive political trends, and the tradition of cooperation. The factors that may prevent a country from adopting NSL include decentralized educational policy and funding, diversity and the large number of institutions, the concern for the “Big Deal,” and the concern for monopoly.

  17. Optimizing Concurrent M3-Transactions: A Fuzzy Constraint Satisfaction Approach

    Directory of Open Access Journals (Sweden)

    Peng LI

    2004-10-01

    Full Text Available Due to the high connectivity and great convenience, many E-commerce application systems have a high transaction volume. Consequently, the system state changes rapidly and it is likely that customers issue transactions based on out-of-date state information. Thus, the potential of transaction abortion increases greatly. To address this problem, we proposed an M3-transaction model. An M3-transaction is a generalized transaction where users can issue their preferences in a request by specifying multiple criteria and optional data resources simultaneously within one transaction. In this paper, we introduce the transaction grouping and group evaluation techniques. We consider evaluating a group of M3-transactions arrived to the system within a short duration together. The system makes optimal decisions in allocating data to transactions to achieve better customer satisfaction and lower transaction failure rate. We apply the fuzzy constraint satisfaction approach for decision-making. We also conduct experimental studies to evaluate the performance of our approach. The results show that the M3-transaction with group evaluation is more resilient to failure and yields much better performance than the traditional transaction model.

  18. Optimizing Concurrent M3-Transactions: A Fuzzy Constraint Satisfaction Approach

    Directory of Open Access Journals (Sweden)

    Peng LI

    2004-10-01

    Full Text Available Due to the high connectivity and great convenience, many E-commerce application systems have a high transaction volume. Consequently, the system state changes rapidly and it is likely that customers issue transactions based on out-of-date state information. Thus, the potential of transaction abortion increases greatly. To address this problem, we proposed an M3-transaction model. An M3-transaction is a generalized transaction where users can issue their preferences in a request by specifying multiple criteria and optional data resources simultaneously within one transaction. In this paper, we introduce the transaction grouping and group evaluation techniques. We consider evaluating a group of M3-transactions arrived to the system within a short duration together. The system makes optimal decisions in allocating data to transactions to achieve better customer satisfaction and lower transaction failure rate. We apply the fuzzy constraint satisfaction approach for decision-making. We also conduct experimental studies to evaluate the performance of our approach. The results show that the M3-transaction with group evaluation is more resilient to failure and yields much better performance than the traditional transaction model.

  19. Analytical Study of Usage of Electronic Information Resources at Pharmacopoeial Libraries in India

    Directory of Open Access Journals (Sweden)

    Sunil Tyagi

    2014-02-01

    Full Text Available The objective of this study is to know the rate and purpose of the use of e-resource by the scientists at pharmacopoeial libraries in India. Among other things, this study examined the preferences of the scientists toward printed books and journals, electronic information resources, and pattern of using e-resources. Non-probability sampling specially accidental and purposive technique was applied in the collection of primary data through administration of user questionnaire. The sample respondents chosen for the study consists of principle scientific officer, senior scientific officer, scientific officer, and scientific assistant of different division of the laboratories, namely, research and development, pharmaceutical chemistry, pharmacovigilance, pharmacology, pharmacogonosy, and microbiology. The findings of the study reveal the personal experiences and perceptions they have had on practice and research activity using e-resource. The major findings indicate that of the total anticipated participants, 78% indicated that they perceived the ability to use computer for electronic information resources. The data analysis shows that all the scientists belonging to the pharmacopoeial libraries used electronic information resources to address issues relating to drug indexes and compendia, monographs, drugs obtained through online databases, e-journals, and the Internet sources—especially polices by regulatory agencies, contacts, drug promotional literature, and standards.

  20. Connecting knowledge resources to the veterinary electronic health record: opportunities for learning at point of care.

    Science.gov (United States)

    Alpi, Kristine M; Burnett, Heidi A; Bryant, Sheila J; Anderson, Katherine M

    2011-01-01

    Electronic health records (EHRs) provide clinical learning opportunities through quick and contextual linkage of patient signalment, symptom, and diagnosis data with knowledge resources covering tests, drugs, conditions, procedures, and client instructions. This paper introduces the EHR standards for linkage and the partners-practitioners, content publishers, and software developers-necessary to leverage this possibility in veterinary medicine. The efforts of the American Animal Hospital Association (AAHA) Electronic Health Records Task Force to partner with veterinary practice management systems to improve the use of controlled vocabulary is a first step in the development of standards for sharing knowledge at the point of care. The Veterinary Medical Libraries Section (VMLS) of the Medical Library Association's Task Force on Connecting the Veterinary Health Record to Information Resources compiled a list of resources of potential use at point of care. Resource details were drawn from product Web sites and organized by a metric used to evaluate medical point-of-care resources. Additional information was gathered from questions sent by e-mail and follow-up interviews with two practitioners, a hospital network, two software developers, and three publishers. Veterinarians with electronic records use a variety of information resources that are not linked to their software. Systems lack the infrastructure to use the Infobutton standard that has been gaining popularity in human EHRs. While some veterinary knowledge resources are digital, publisher sites and responses do not indicate a Web-based linkage of veterinary resources with EHRs. In order to facilitate lifelong learning and evidence-based practice, veterinarians and educators of future practitioners must demonstrate to veterinary practice software developers and publishers a clinically-based need to connect knowledge resources to veterinary EHRs.

  1. Improving access to information – defining core electronic resources for research and wellbeing

    Directory of Open Access Journals (Sweden)

    Kristiina Hormia-Poutanen

    2007-11-01

    Full Text Available Research and innovation are listed as the key success factors for the future development of Finnish prosperity and the Finnish economy. The Finnish libraries have developed a scenario to support this vision. University, polytechnic and research institute libraries as well as public libraries have defined the core electronic resources necessary to improve access to information in Finland. The primary aim of this work has been to provide information and justification for central funding for electronic resources to support the national goals. The secondary aim is to help with the reallocation of existing central funds to better support access to information.

  2. Elektronik Bilgi Kaynaklarının Seçimi / Selection of Electronic Information Resources

    Directory of Open Access Journals (Sweden)

    Pınar Al

    2003-04-01

    Full Text Available For many years, library users have used only from the printed media in order to get the information that they have needed. Today with the widespread use of the Web and the addition of electronic information resources to library collections, the use of information in the electronic environment as well as in printed media is started to be used. In time, such types of information resources as, electronic journals, electronic books, electronic encyclopedias, electronic dictionaries and electronic theses have been added to library collections. In this study, selection criteria that can be used for electronic information resources are discussed and suggestions are provided for libraries that try to select electronic information resources for their collections.

  3. The Luminosity Function of M3

    CERN Document Server

    Rood, R T; Paltrinieri, B; Ferraro, F R; Pecci, F F; Dorman, B; Chieffi, A; Straniero, O; Buonanno, R

    1999-01-01

    We present a high precision, large sample luminosity function (LF) for the Galactic globular cluster M3. With a combination of ground based and Hubble Space Telescope data we cover the entire radial extent of the cluster. The observed LF is well fit by canonical standard stellar models from the red giant branch (RGB) tip to below the main sequence turnoff point. Specifically, neither the RGB LF-bump nor subgiant branch LF indicate any breakdown in the standard models. On the main sequence we find evidence for a flat initial mass function and for mass segregation due to the dynamical evolution of the cluster.

  4. Using Electronic Information Resources Centers by Faculty Members at University Education: Competencies, Needs and Challenges

    Science.gov (United States)

    Abouelenein, Yousri

    2017-01-01

    This study aimed at investigating the factual situation of electronic information resources centers to faculty members at university education. Competencies that faculty members should possess regarding this issue were determined. Also their needs for (scientific research skills and teaching) were assessed. In addition, problems that hinder their…

  5. Localising versus standardising electronic human resource management: complexities and tensions between HRM and IT departments

    NARCIS (Netherlands)

    Tate, Mary; Furtmueller, E.; Wilderom, C.P.M.

    2013-01-01

    In this paper, we provide an analysis of the complexities involved during global e-HRM (Electronic Human Resource Management) implementation. We present findings from a case study on the challenge of global integration versus local responsiveness of e-HRM systems. We take a local site lens, analysin

  6. Use of Electronic Information Resources among Research Scholars in the Islamia University of Bahawalpur, Pakistan

    Science.gov (United States)

    Amjad, Anam; Ahmed, Shamshad; Bin Naeem, Salman

    2013-01-01

    This study examined the use of electronic resources among academic scholars of The Islamia University of Bahawalpur (IUB), Punjab, Pakistan. A quantitative survey was found most convenient and useful for this study. The total population of the study was 169 research students in IUB. The response rate was 79% and 133 utilizable responses were coded…

  7. The Acquisition and Management of Electronic Resources: Can Use Justify Cost?

    Science.gov (United States)

    Koehn, Shona L.; Hawamdeh, Suliman

    2010-01-01

    As library collections increasingly become digital, libraries are faced with many challenges regarding the acquisition and management of electronic resources. Some of these challenges include copyright and fair use, the first-sale doctrine, licensing versus ownership, digital preservation, long-term archiving, and, most important, the issue of…

  8. 电子资源的编目策略%Cataloging Strategies of Electronic Resources

    Institute of Scientific and Technical Information of China (English)

    王亚林

    2012-01-01

    Compared with traditional paper resources, electronic resources have following characteristics which determine different cataloging strategies from paper resources. These characteristics are huge quantity, updating rapidly, coexistence of a variety of manifestations. The source data of electronic resources is usually provided by the database agent. The cataloging of electronic resources is based on the Chapter IX of Anglo-American Cataloging Rules, Library of Congress Rule Interpretations and rules of Cooperative Online Serials. There are two major cataloging methods for electronic resources abroad, they are single record approach and separate record approach. Peking University Library chooses the latter method and batches cataloging automatically using the source data.%电子资源吲传统纸质资源相比,具有数量大、更新快、多种载体表现并行等特点,且大部分出版机构能够提供数据源数据。这些特点决定了.电子资源应采取与纸质文献不同的编目策略。电子资源编日的主要依据是《英美编日条例》的第9章、美国《国会图书馆条例解释》及全美期刊合作编目计划的规定。对于电子资源的编目,国外有单一记录编目法和分散记录编目法。北京大学图书馆采用后者,同时利用数据源数据批舒自动编目。

  9. Power resource management and low-power remote wireless RF electronics

    Science.gov (United States)

    Jannson, Tomasz; Forrester, Thomas; Degrood, Kevin; Lee, Kang; Gans, Eric; Walter, Kevin

    2009-05-01

    Battery power resource management becomes a critical issue in the case of self-powered remote wireless RF electronics, where the basic parameter is time of system operation before battery recharging or battery replacement. In such cases, very often related to physical protection against antitampering (AT), proper theoretical modeling of a battery driven power supply in the context of a given digital electronic system is of utmost importance. Such modeling should include various types of batteries (primary and secondary), various self-discharge processes in different temperatures, and even energy harvesting, the latter to supply power for long-term content, low-power electronic subsystems. In this paper we analyze simple modeling of resource power management, including variations of all of these parameters and energy harvesting.

  10. Identifying and evaluating electronic learning resources for use in adult-gerontology nurse practitioner education.

    Science.gov (United States)

    Thompson, Hilaire J; Belza, Basia; Baker, Margaret; Christianson, Phyllis; Doorenbos, Ardith; Nguyen, Huong

    2014-01-01

    Enhancing existing curricula to meet newly published adult-gerontology advanced practice registered nurse (APRN) competencies in an efficient manner presents a challenge to nurse educators. Incorporating shared, published electronic learning resources (ELRs) in existing or new courses may be appropriate in order to assist students in achieving competencies. The purposes of this project were to (a) identify relevant available ELR for use in enhancing geriatric APRN education and (b) to evaluate the educational utility of identified ELRs based on established criteria. A multilevel search strategy was used. Two independent team members reviewed identified ELR against established criteria to ensure utility. Only resources meeting all criteria were retained. Resources were found for each of the competency areas and included formats such as podcasts, Web casts, case studies, and teaching videos. In many cases, resources were identified using supplemental strategies and not through traditional search or search of existing geriatric repositories. Resources identified have been useful to advanced practice educators in improving lecture and seminar content in a particular topic area and providing students and preceptors with additional self-learning resources. Addressing sustainability within geriatric APRN education is critical for sharing of best practices among educators and for sustainability of teaching and related resources. © 2014.

  11. Library Electronic Resource Sharing Among Liberal Arts Colleges: ACS Palladian Alliance Project

    Directory of Open Access Journals (Sweden)

    Wenxian Zhang

    1997-03-01

    Full Text Available 無Effective electronic resource sharing is critical to library information services of the 1990s. Explosion of data and increased cost of information force libraries to work together, and technological advancements present the library service profession a platform for resource sharing. The Palladian Alliance Project of the Associated Colleges of the South is designed to provides ACS member institutions an effective means to enhance information access for their faculty and students, and achieve significant cost containment in the years to come.

  12. Availability, Level of Use and Constraints to Use of Electronic Resources by Law Lecturers in Public Universities in Nigeria

    Science.gov (United States)

    Amusa, Oyintola Isiaka; Atinmo, Morayo

    2016-01-01

    (Purpose) This study surveyed the level of availability, use and constraints to use of electronic resources among law lecturers in Nigeria. (Methodology) Five hundred and fifty-two law lecturers were surveyed and four hundred and forty-two responded. (Results) Data analysis revealed that the level of availability of electronic resources for the…

  13. Transport Coefficients of Black M3-Branes

    CERN Document Server

    Dhuria, Mansi

    2014-01-01

    The local uplift via local SYZ mirror symmetry of (M)N (fractional)D3-branes, and wrapped N_f flavor D7-branes in the presence of a black-hole resulting in a non-Kaehler resolved warped deformed conifold (NKRWDC) in [1], was carried out in [2] and resulted in black M3-branes; the deviation from the ISD condition of G_3 proportional to the square of the resolution parameter, in the limits of [1] and MQGP limit of [2], imposed on (g_s,M,N), can be ignored [3]. The uplift, if valid globally, asymptotes to M5-branes wrapping a two-cycle (homologously an (large) integer sum of two-spheres) in AdS_5xM_6. Interestingly, in the limits of [1]/ [2], assuming the deformation > resolution, by estimating the five SU(3) structure torsion (\\tau) classes W_{1,2,3,4,5} we show that \\tau\\in W_5 in the large-r limit, implying the NKRWDC reduces to a warped Kaehler deformed conifold. Further, the local T^3 of [2] in the large-r limit and the limits of [1] and the `MQGP' limit of [2], satisfies the same conditions as the maximal ...

  14. Formando planetas habitables en estrellas M3

    Science.gov (United States)

    Dugaro, A.; de Elía, G. C.; Brunini, A.

    2016-08-01

    Studies of stellar evolution allow us to infer that the low-mass stars are the most abundant in the galaxy. In the present investigation, we analyze the formation of planetary systems without gas giants around M3-type stars, which have a mass of 0.29 M. In particular, we are interested in studying the terrestrial-like planet formation processes and water delivery in the Habitable Zone (HZ) of those systems. To develop this investigation, we assume massive protoplanetary disks for such stars, which have 5 of the mass of the central star. Once defined the working disk, we use a semi-analytical model, which is able to determine the distribution of planetary embryos and planetesimals at the end of the gaseous phase. Then, these distributions are used as initial conditions for running -body simulations. Due to the stochastic nature of the accretion process, we carry out ten -body simulations in order to analyze the evolution of the planetary systems after the gas dissipation. Our results suggest the efficient formation of terrestrial-like planets in the HZ with a wide range of masses and water contents. The planets formed in the HZ of the system have masses between 0.07 M and 0.15 M and final water contents between 5.4 and 29 by mass. The physical properties of the terrestrial-like planets formed in the HZ of our simulations suggest that they should be able to retain a permanent and substantial atmosphere.

  15. Conformable M3 Microsystems for Aerodynamic Control

    Science.gov (United States)

    2007-11-02

    we have fabricated sensors, actuators, and electronics all on the same chip. Control: • A CMOS control circuit has been designed and sent to MOSIS ...macro aerodynamic devices. (3) After the chip from MOSIS is fabricated, it will be tested to confirm that it works as designed. (4) The process and...identify the separation point from the outputs of shear stress sensors and drive the corresponding actuators. The layout has been sent to MOSIS for

  16. New BMW M3 sports coupe; Neues Sportcoupe M3 von BMW

    Energy Technology Data Exchange (ETDEWEB)

    Biermann, A.; Friedmann, S.; Gehrig, H.; Huebner, W.; Weidhase, U. [Bayerische Motoren Werke AG (BMW), Muenchen (Germany); Koplenig, W. [BMW, Muenchen (Germany). Fachbereich Karosserie

    2000-10-01

    Since 1972 Motorsport (which has been known as BMW M since 1994) has been manufacturing automobiles of exceptionally sporting character on the basis of suitable series-production cars. With its new M3, BMW M continues this tradition. It is a sports coupe based on the latest BMW 3 Series model line. Its sports design embodies the essentials of BMW M's performance philosophy. Both visible and invisible 'highlights' such as the new high-speed driveline rating elevate its longitudinal and lateral driving dynamics to the level of a racing car. We have also succeeded in maintaining the basic car's unlimited suitability for everyday use. The new M3 is therefore a fully-fledged sports car without the typical disadvantages of this type of vehicle. (orig.) [German] Bereits seit 1972 entstehen bei BMW Motorsport (seit 1994 BMW M) auf der Basis von Serienfahrzeugen Automobile mit aussergewoehnlichen sportlichen Eigenschaften. Mit dem neuen M3, abgeleitet von der aktuellen BMW Dreier-Reihe, setzt BMW M diese Tradition fort. Das Sportcoupe erschliesst ueber die weiterentwickelte Hochdrehzahlauslegung eine Fahrdynamik in Laengs- und Querrichtung auf dem Niveau eines Rennsportwagens. Gleichzeitig ist es gelungen, die uneingeschraenkte Alltagstauglichkeit des Basis-Fahrzeugs zu erhalten. Der neue M3 ist somit ein vollwertiger Sportwagen, vermeidet aber dessen typische Nachteile. (orig.)

  17. Potential resource and toxicity impacts from metals in waste electronic devices.

    Science.gov (United States)

    Woo, Seung H; Lee, Dae Sung; Lim, Seong-Rin

    2016-04-01

    As a result of the continuous release of new electronic devices, existing electronic devices are quickly made obsolete and rapidly become electronic waste (e-waste). Because e-waste contains a variety of metals, information about those metals with the potential for substantial environmental impact should be provided to manufacturers, recyclers, and disposers to proactively reduce this impact. This study assesses the resource and toxicity (i.e., cancer, noncancer, and ecotoxicity) potentials of various heavy metals commonly found in e-waste from laptop computers, liquid-crystal display (LCD) monitors, LCD TVs, plasma TVs, color cathode ray tube (CRT) TVs, and cell phones and then evaluates such potentials using life cycle impact-based methods. Resource potentials derive primarily from Cu, Sb, Ag, and Pb. Toxicity potentials derive primarily from Pb, Ni, and Hg for cancer toxicity; from Pb, Hg, Zn, and As for noncancer toxicity; and from Cu, Pb, Hg, and Zn for ecotoxicity. Therefore, managing these heavy metals should be a high priority in the design, recycling, and disposal stages of electronic devices.

  18. Model of e-learning with electronic educational resources of new generation

    Directory of Open Access Journals (Sweden)

    A. V. Loban

    2017-01-01

    Full Text Available Purpose of the article: improving of scientific and methodical base of the theory of the е-learning of variability. Methods used: conceptual and logical modeling of the е-learning of variability process with electronic educational resource of new generation and system analysis of the interconnection of the studied subject area, methods, didactics approaches and information and communication technologies means. Results: the formalization complex model of the е-learning of variability with electronic educational resource of new generation is developed, conditionally decomposed into three basic components: the formalization model of the course in the form of the thesaurusclassifier (“Author of e-resource”, the model of learning as management (“Coordination. Consultation. Control”, the learning model with the thesaurus-classifier (“Student”. Model “Author of e-resource” allows the student to achieve completeness, high degree of didactic elaboration and structuring of the studied material in triples of variants: modules of education information, practical task and control tasks; the result of the student’s (author’s of e-resource activity is the thesaurus-classifier. Model of learning as management is based on the principle of personal orientation of learning in computer environment and determines the logic of interaction between the lecturer and the student when determining the triple of variants individually for each student; organization of a dialogue between the lecturer and the student for consulting purposes; personal control of the student’s success (report generation and iterative search for the concept of the class assignment in the thesaurus-classifier before acquiring the required level of training. Model “Student” makes it possible to concretize the learning tasks in relation to the personality of the student and to the training level achieved; the assumption of the lecturer about the level of training of a

  19. [Use of internet and electronic resources among Spanish intensivist physicians. First national survey].

    Science.gov (United States)

    Gómez-Tello, V; Latour-Pérez, J; Añón Elizalde, J M; Palencia-Herrejón, E; Díaz-Alersi, R; De Lucas-García, N

    2006-01-01

    Estimate knowledge and use habits of different electronic resources in a sample of Spanish intensivists: Internet, E-mail, distribution lists, and use of portable electronic devices. Self-applied questionnaire. A 50-question questionnaire was distributed among Spanish intensivists through the hospital marketing delegates of a pharmaceutical company and of electronic forums. A total of 682 questionnaires were analyzed (participation: 74%). Ninety six percent of those surveyed used Internet individually: 67% admitted training gap. Internet was the second source of clinical consultations most used (61%), slightly behind consultation to colleagues (65%). The pages consulted most were bibliographic databases (65%) and electronic professional journals (63%), with limited use of Evidence Based Medicine pages (19%). Ninety percent of those surveyed used e-mail regularly in the practice of their profession, although 25% admitted that were not aware of its possibilities. The use of E-mail decreased significantly with increase in age. A total of 62% of the intensivists used distribution lists. Of the rest, 42% were not aware of its existence and 32% admitted they had insufficient training to handle them. Twenty percent of those surveyed had portable electronic devices and 64% considered it useful, basically due to its rapid consultation at bedside. Female gender was a negative predictive factor of its use (OR 0.35; 95% CI 0.2-0.63; p=0.0002). A large majority of the Spanish intensivists use Internet and E-mail. E-mail lists and use of portable devices are still underused resources. There are important gaps in training and infrequent use of essential pages. There are specific groups that require directed educational policies.

  20. Review of material recovery from used electric and electronic equipment-alternative options for resource conservation.

    Science.gov (United States)

    Friege, Henning

    2012-09-01

    For waste from electric and electronic equipment, the WEEE Directive stipulates the separate collection of electric and electronic waste. As to new electric and electronic devices, the Restriction of Hazardous Substances (RoHS) Directive bans the use of certain chemicals dangerous for man and environment. From the implementation of the WEEE directive, many unsolved problems have been documented: poor collection success, emission of dangerous substances during collection and recycling, irretrievable loss of valuable metals among others. As to RoHS, data from the literature show a satisfying success. The problems identified in the process can be reduced to some basic dilemmas at the borders between waste management, product policy and chemical safety. The objectives of the WEEE Directive and the specific targets for use and recycling of appliances are not consistent. There is no focus on scarce resources. Extended producer responsibility is not sufficient to guarantee sustainable waste management. Waste management reaches its limits due to problems of implementation but also due to physical laws. A holistic approach is necessary looking at all branch points and sinks in the stream of used products and waste from electric and electronic equipment. This may be done with respect to the general rules for sustainable management of material streams covering the three dimensions of sustainable policy. The relationships between the players in the field of electric and electronic devices have to be taken into account. Most of the problems identified in the implementation process will not be solved by the current amendment of the WEEE Directive.

  1. Aufwand und Nutzen des Electronic Resource Management Systems RMS an der UB Kassel

    Directory of Open Access Journals (Sweden)

    Tobias Pohlmann

    2016-03-01

    The university library of Kassel therefore uses SemperTool’s web-based electronic resource management system RMS. This paper presents the functionality of this system and makes an estimate of the expenditure of work necessary to enter all relevant information about licensed databases, e-book and e-journal packages with the corresponding individual resources. It also describes existing and projected tools for analysis and evaluation, which are decisive for the usefulness of such a system, and concludes with the satisfaction reached at the university library of Kassel. These experiences may help other libraries to decide whether or not to introduce RMS or a comparable system.

  2. ELECTRONIC EDUCATIONAL RESOURCES FOR ONLINE SUPPORT OF MODERN CHEMISTRY CLASSES IN SPECIALIZED SCHOOL

    Directory of Open Access Journals (Sweden)

    Maria D. Tukalo

    2013-09-01

    Full Text Available This article contains material of some modern electronic educational resources that can be used via the Internet to support the modern chemistry classes in specialized school. It was drawn attention to the educational chemical experiments as means of knowledge; simulated key motivational characteristics to enhance students interest for learning subjects, their cognitive and practical activity in the formation of self-reliance and self-creative; commented forecasts for creating of conditions to enhance the creative potential of students in a modern learning environment.

  3. Teachers' Link to Electronic Resources in the Library Media Center: A Local Study of Awareness, Knowledge, and Influence

    Science.gov (United States)

    Williams, Teresa D.; Grimble, Bonnie J.; Irwin, Marilyn

    2004-01-01

    High school students often use online databases and the Internet in the school library media center (SLMC) to complete teachers' assignments. This case study used a survey to assess teachers' awareness of electronic resources, and to determine whether their directions influence student use of these resources in the SLMC. Participants were teachers…

  4. Impact of Knowledge Resources Linked to an Electronic Health Record on Frequency of Unnecessary Tests and Treatments

    Science.gov (United States)

    Goodman, Kenneth; Grad, Roland; Pluye, Pierre; Nowacki, Amy; Hickner, John

    2012-01-01

    Introduction: Electronic knowledge resources have the potential to rapidly provide answers to clinicians' questions. We sought to determine clinicians' reasons for searching these resources, the rate of finding relevant information, and the perceived clinical impact of the information they retrieved. Methods: We asked general internists, family…

  5. Reducing Clinical Trial Monitoring Resource Allocation and Costs Through Remote Access to Electronic Medical Records

    Science.gov (United States)

    Uren, Shannon C.; Kirkman, Mitchell B.; Dalton, Brad S.; Zalcberg, John R.

    2013-01-01

    Purpose: With electronic medical records (eMRs), the option now exists for clinical trial monitors to perform source data verification (SDV) remotely. We report on a feasibility study of remote access to eMRs for SDV and the potential advantages of such a process in terms of resource allocation and cost. Methods: The Clinical Trials Unit at the Peter MacCallum Cancer Centre, in collaboration with Novartis Pharmaceuticals Australia, conducted a 6-month feasibility study of remote SDV. A Novartis monitor was granted dedicated software and restricted remote access to the eMR portal of the cancer center, thereby providing an avenue through which perform SDV. Results: Six monitoring visits were conducted during the study period, four of which were performed remotely. The ability to conduct two thirds of the monitoring visits remotely in this complex phase III study resulted in an overall cost saving to Novartis. Similarly, remote monitoring eased the strain on internal resources, particularly monitoring space and hospital computer terminal access, at the cancer center. Conclusion: Remote access to patient eMRs for SDV is feasible and is potentially an avenue through which resources can be more efficiently used. Although this feasibility study involved limited numbers, there is no limit to scaling these processes to any number of patients enrolled onto large clinical trials. PMID:23633977

  6. Electronic theses and dissertations: a review of this valuable resource for nurse scholars worldwide.

    Science.gov (United States)

    Goodfellow, L M

    2009-06-01

    A worldwide repository of electronic theses and dissertations (ETDs) could provide worldwide access to the most up-to-date research generated by masters and doctoral students. Until that international repository is established, it is possible to access some of these valuable knowledge resources. ETDs provide a technologically advanced medium with endless multimedia capabilities that far exceed the print and bound copies of theses and dissertations housed traditionally in individual university libraries. CURRENT USE: A growing trend exists for universities worldwide to require graduate students to submit theses or dissertations as electronic documents. However, nurse scholars underutilize ETDs, as evidenced by perusing bibliographic citation lists in many of the research journals. ETDs can be searched for and retrieved through several digital resources such as the Networked Digital Library of Theses and Dissertations (http://www.ndltd.org), ProQuest Dissertations and Theses (http://www.umi.com), the Australasian Digital Theses Program (http://adt.caul.edu.au/) and through individual university web sites and online catalogues. An international repository of ETDs benefits the community of nurse scholars in many ways. The ability to access recent graduate students' research electronically from anywhere in the world is advantageous. For scholars residing in developing countries, access to these ETDs may prove to be even more valuable. In some cases, ETDs are not available for worldwide access and can only be accessed through the university library from which the student graduated. Public access to university library ETD collections is not always permitted. Nurse scholars from both developing and developed countries could benefit from ETDs.

  7. A preliminary categorization of end-of-life electrical and electronic equipment as secondary metal resources.

    Science.gov (United States)

    Oguchi, Masahiro; Murakami, Shinsuke; Sakanakura, Hirofumi; Kida, Akiko; Kameya, Takashi

    2011-01-01

    End-of-life electrical and electronic equipment (EEE) has recently received attention as a secondary source of metals. This study examined characteristics of end-of-life EEE as secondary metal resources to consider efficient collection and metal recovery systems according to the specific metals and types of EEE. We constructed an analogy between natural resource development and metal recovery from end-of-life EEE and found that metal content and total annual amount of metal contained in each type of end-of-life EEE should be considered in secondary resource development, as well as the collectability of the end-of-life products. We then categorized 21 EEE types into five groups and discussed their potential as secondary metal resources. Refrigerators, washing machines, air conditioners, and CRT TVs were evaluated as the most important sources of common metals, and personal computers, mobile phones, and video games were evaluated as the most important sources of precious metals. Several types of small digital equipment were also identified as important sources of precious metals; however, mid-size information and communication technology (ICT) equipment (e.g., printers and fax machines) and audio/video equipment were shown to be more important as a source of a variety of less common metals. The physical collectability of each type of EEE was roughly characterized by unit size and number of end-of-life products generated annually. Current collection systems in Japan were examined and potentially appropriate collection methods were suggested for equipment types that currently have no specific collection systems in Japan, particularly for video games, notebook computers, and mid-size ICT and audio/video equipment.

  8. From Millennium ERM to Proquest 360 Resource Manager: Implementing a new Electronic Resources Management System ERMS in an International Graduate Research University in Saudi Arabia

    KAUST Repository

    Ramli, Rindra M.

    2017-05-17

    An overview of the Recommendation Study and the subsequent Implementation of a new Electronic Resources Management system ERMS in an international graduate research university in the Kingdom of Saudi Arabia. It covers the timeline, deliverables and challenges as well as lessons learnt by the Project Team.

  9. Electronic tracking of human resource skills and knowledge, just in time training, manageable due diligence

    Energy Technology Data Exchange (ETDEWEB)

    Kolodziej, M.A. [Quick Test International Inc., (Canada). Canadian Technology Human Resource Board; Baker, O. [KeySpan Energy Canada, Calgary, AB (Canada)

    2001-06-01

    KeySpan Energy Canada is in the process of obtaining recognition of various occupational profiles including pipeline operators, inspectors, and field and plant operators from various certifying organizations. The process of allowing individuals to obtain certification is recognized by Canadian Technology Human Resources Board as a step towards national standards for technologists and technicians. Proven competency is a must for workers in todays oil industry in response to increasingly stringent government safety regulations, environmental concerns and high public scrutiny. Quick Test international Inc. has developed a management tool in collaboration with end users at KeySpan Energy Canada. It is an electronic, Internet based competency tool for tracking personal competencies and maintaining continued competency. Response to the tool has been favourable. 2 refs., 4 figs.

  10. [HYGIENIC REGULATION OF THE USE OF ELECTRONIC EDUCATIONAL RESOURCES IN THE MODERN SCHOOL].

    Science.gov (United States)

    Stepanova, M I; Aleksandrova, I E; Sazanyuk, Z I; Voronova, B Z; Lashneva, L P; Shumkova, T V; Berezina, N O

    2015-01-01

    We studied the effect of academic studies with the use a notebook computer and interactive whiteboard on the functional state of an organism of schoolchildren. Using a complex of hygienic and physiological methods of the study we established that regulation of the computer activity of students must take into account not only duration but its intensity either. Design features of a notebook computer were shown both to impede keeping the optimal working posture in primary school children and increase the risk offormation of disorders of vision and musculoskeletal system. There were established the activating influence of the interactive whiteboard on performance activities and favorable dynamics of indices of the functional state of the organism of students under keeping optimal density of the academic study and the duration of its use. There are determined safety regulations of the work of schoolchildren with electronic resources in the educational process.

  11. Medical Image Resource Center--making electronic teaching files from PACS.

    Science.gov (United States)

    Lim, C C Tchoyoson; Yang, Guo Liang; Nowinski, Wieslaw L; Hui, Francis

    2003-12-01

    A picture archive and communications system (PACS) is a rich source of images and data suitable for creating electronic teaching files (ETF). However, the potential for PACS to support nonclinical applications has not been fully realized: at present there is no mechanism for PACS to identify and store teaching files; neither is there a standardized method for sharing such teaching images. The Medical Image Resource Center (MIRC) is a new central image repository that defines standards for data exchange among different centers. We developed an ETF server that retrieves digital imaging and communication in medicine (DICOM) images from PACS, and enables users to create teaching files that conform to the new MIRC schema. We test-populated our ETF server with illustrative images from the clinical case load of the National Neuroscience Institute, Singapore. Together, PACS and MIRC have the potential to benefit radiology teaching and research.

  12. Electronic Human Resource Management (e-HRM of Hotel Business in Phuket

    Directory of Open Access Journals (Sweden)

    Kitimaporn Choochote

    2015-04-01

    Full Text Available This research aims to study the pattern of the electronic human resources management (e-HRM of the hotel business in Phuket. The study is conducted with the implementation of field data and in-depth interview of hotels’ HR managers. In consequence, the study reveals that the hotel business has applied the use of the e-HRM varying in job recruitment (15 percent, employee engagement (55 percent, organizational file structure (10 percent, idea and creativity exchanges (38 percent and assessment system (6 percent. However, considered as 100 percent, the hotel business has not prepared to apply the use of the e-HRM in salary system, learning and training program, welfare allocation and career development.

  13. Using mobile electronic devices to deliver educational resources in developing countries.

    Science.gov (United States)

    Mazal, Jonathan Robert; Ludwig, Rebecca

    2015-01-01

    Developing countries have far fewer trained radiography professionals than developed countries, which exacerbates the limited access to imaging services. The lack of trained radiographers reflects, in part, limited availability of radiographer-specific educational resources. Historically, organizations that provided such resources in the developing world faced challenges related to the limited stock of current materials as well as expenses associated with shipping and delivery. Four mobile electronic devices (MEDs) were loaded with educational content (e-books, PDFs, and digital applications) spanning major radiography topics. The MEDs were distributed to 4 imaging departments in Ghana, India, Nepal, and Nigeria based on evidence of need for radiography-specific resources, as revealed by survey responses. A cost comparison of postal delivery vs digital delivery of educational content was performed. The effectiveness of delivering additional content via Wi-Fi transmission also was evaluated. Feedback was solicited on users' experience with the MEDs as a delivery tool for educational content. An initial average per e-book expense of $30.05, which included the cost of the device, was calculated for the MED delivery method compared with $15.56 for postal delivery of printed materials. The cost of the MED delivery method was reduced to an average of $10.05 for subsequent e-book deliveries. Additional content was successfully delivered via Wi-Fi transmission to all recipients during the 3-month follow-up period. Overall user feedback on the experience was positive, and ideas for enhancing the MED-based method were identified. Using MEDs to deliver radiography-specific educational content appears to be more cost effective than postal delivery of printed materials on a long-term basis. MEDs are more efficient for providing updates to educational materials. Customization of content to department needs, and using projector devices could enhance the usefulness of MEDs for

  14. Plastics disassembly versus bulk recycling: engineering design for end-of-life electronics resource recovery.

    Science.gov (United States)

    Rios, Pedro; Stuart, Julie Ann; Grant, Ed

    2003-12-01

    Annual plastic flows through the business and consumer electronics manufacturing supply chain include nearly 3 billion lb of high-value engineering plastics derived from petroleum. The recovery of resource value from this stream presents critical challenges in areas of materials identification and recycling process design that demand new green engineering technologies applied together with life cycle assessment and ecological supply chain analysis to create viable plastics-to-plastics supply cycles. The sustainable recovery of potentially high-value engineering plastics streams requires that recyclers either avoid mixing plastic parts or purify later by separating smaller plastic pieces created in volume reduction (shredding) steps. Identification and separation constitute significant barriers in the plastics-to-plastics recycling value proposition. In the present work, we develop a model that accepts randomly arriving electronic products to study scenarios by which a recycler might identify and separate high-value engineering plastics as well as metals. Using discrete eventsimulation,we compare current mixed plastics recovery with spectrochemical plastic resin identification and subsequent sorting. Our results show that limited disassembly with whole-part identification can produce substantial yields in separated streams of recovered engineering thermoplastics. We find that disassembly with identification does not constitute a bottleneck, but rather, with relatively few workers, can be configured to pull the process and thus decrease maximum staging space requirements.

  15. SAGES: a suite of freely-available software tools for electronic disease surveillance in resource-limited settings.

    Directory of Open Access Journals (Sweden)

    Sheri L Lewis

    Full Text Available Public health surveillance is undergoing a revolution driven by advances in the field of information technology. Many countries have experienced vast improvements in the collection, ingestion, analysis, visualization, and dissemination of public health data. Resource-limited countries have lagged behind due to challenges in information technology infrastructure, public health resources, and the costs of proprietary software. The Suite for Automated Global Electronic bioSurveillance (SAGES is a collection of modular, flexible, freely-available software tools for electronic disease surveillance in resource-limited settings. One or more SAGES tools may be used in concert with existing surveillance applications or the SAGES tools may be used en masse for an end-to-end biosurveillance capability. This flexibility allows for the development of an inexpensive, customized, and sustainable disease surveillance system. The ability to rapidly assess anomalous disease activity may lead to more efficient use of limited resources and better compliance with World Health Organization International Health Regulations.

  16. Magnetic circular dichroism of porphyrin lanthanide M3+ complexes.

    Science.gov (United States)

    Andrushchenko, Valery; Padula, Daniele; Zhivotova, Elena; Yamamoto, Shigeki; Bouř, Petr

    2014-10-01

    Lanthanide complexes exhibit interesting spectroscopic properties yielding many applications as imaging probes, natural chirality amplifiers, and therapeutic agents. However, many properties are not fully understood yet. Therefore, we applied magnetic circular dichroism (MCD) spectroscopy, which provides enhanced information about the underlying electronic structure to a series of lanthanide compounds. The metals in the M(3+) state included Y, La, Eu, Tb, Dy, Ho, Er, Tm, Yb, and Lu; the spectra were collected for selected tetraphenylporphin (TPP) and octaethylporphin (OEP) complexes in chloroform. While the MCD and UV-VIS absorption spectra were dominated by the porphyrin signal, metal binding significantly modulated them. MCD spectroscopy was found to be better suited to discriminate between various species than absorption spectroscopy alone. The main features and trends in the lanthanide series observed in MCD and absorption spectra of the complexes could be interpreted at the Density Functional Theory (DFT) level, with effective core potentials on metal nuclei. The sum over state (SOS) method was used for simulation of the MCD intensities. The combination of the spectroscopy and quantum-chemical computations is important for understanding the interactions of the metals with the organic compounds.

  17. Genomic standards consortium workshop: metagenomics, metadata and metaanalysis (M3).

    Science.gov (United States)

    Sterk, Peter; Hirschman, Lynette; Field, Dawn; Wooley, John

    2010-01-01

    The M3 workshop has, as its primary focus, the rapidly growing area of metagenomics, including the metadata standards and the meta-analysis approaches needed to organize, process and interpret metagenomics data. The PSB Workshop builds on the first M3 meeting, a Special Interest Group (SIG) meeting at ISMB 2009, organized by the Genomics Standards Consortium.

  18. Impact of Electronic Resources and Usage in Academic Libraries in Ghana: Evidence from Koforidua Polytechnic & All Nations University College, Ghana

    Science.gov (United States)

    Akussah, Maxwell; Asante, Edward; Adu-Sarkodee, Rosemary

    2015-01-01

    The study investigates the relationship between impact of electronic resources and its usage in academic libraries in Ghana: evidence from Koforidua Polytechnic & All Nations University College, Ghana. The study was a quantitative approach using questionnaire to gather data and information. A valid response rate of 58.5% was assumed. SPSS…

  19. Utilization of Electronic Information Resources by Undergraduate Students of University of Ibadan: A Case Study of Social Sciences and Education

    Science.gov (United States)

    Owolabi, Sola; Idowu, Oluwafemi A.; Okocha, Foluke; Ogundare, Atinuke Omotayo

    2016-01-01

    The study evaluated utilization of electronic information resources by undergraduates in the Faculties of Education and the Social Sciences in University of Ibadan. The study adopted a descriptive survey design with a study population of 1872 undergraduates in the Faculties of Education and the Social Sciences in University of Ibadan, from which a…

  20. M3: Matrix Multiplication on MapReduce

    DEFF Research Database (Denmark)

    Silvestri, Francesco; Ceccarello, Matteo

    2015-01-01

    M3 is an Hadoop library for performing dense and sparse matrix multiplication in MapReduce. The library is based on multi-round algorithms exploiting the 3D decomposition of the problem.......M3 is an Hadoop library for performing dense and sparse matrix multiplication in MapReduce. The library is based on multi-round algorithms exploiting the 3D decomposition of the problem....

  1. Human resource requirements for quality-assured electronic data capture of the tuberculosis case register

    Directory of Open Access Journals (Sweden)

    Hoa Nguyen B

    2012-01-01

    Full Text Available Abstract Background The tuberculosis case register is the data source for the reports submitted by basic management units to the national tuberculosis program. Our objective was to measure the data entry time required to complete and double-enter one record, and to estimate the time for the correction of errors in the captured information from tuberculosis case registers in Cambodia and Viet Nam. This should assist in quantifying the additional requirements in human resources for national programs moving towards electronic recording and reporting. Methods Data from a representative sample of tuberculosis case registers from Cambodia and Viet Nam were double-entered and discordances resolved by rechecking the original case register. Computer-generated data entry time recorded the time elapsed between opening of a new record and saving it to disk. Results The dataset comprised 22,732 double-entered records of 11,366 patients (37.1% from Cambodia and 62.9% from Viet Nam. The mean data entry times per record were 97.5 (95% CI: 96.2-98.8 and 66.2 (95% CI: 59.5-73.0 seconds with medians of 90 and 31 s respectively in Cambodia and in Viet Nam. The percentage of records with an error was 6.0% and 39.0% respectively in Cambodia and Viet Nam. Data entry time was inversely associated with error frequency. We estimate that approximately 118-person-hours were required to produce 1,000 validated records. Conclusions This study quantifies differences between two countries for data entry time for the tuberculosis case register and frequencies of data entry errors and suggests that higher data entry speed is partially offset by requiring revisiting more records for corrections.

  2. Use and Cost of Electronic Resources in Central Library of Ferdowsi University Based on E-metrics

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Davarpanah

    2012-07-01

    Full Text Available The purpose of this study was to investigate the usage of electronic journals in Ferdowsi University, Iran based on e-metrics. The paper also aimed to emphasize the analysis of cost-benefit and the correlation between the journal impact factors and the usage data. In this study experiences of Ferdowsi University library on licensing and usage of electronic resources was evaluated by providing a cost-benefit analysis based on the cost and usage statistics of electronic resources. Vendor-provided data were also compared with local usage data. The usage data were collected by tracking web-based access locally, and by collecting vender-provided usage data. The data sources were one-year of vendor-supplied e-resource usage data such as Ebsco, Elsevier, Proquest, Emerald, Oxford and Springer and local usage data collected from the Ferdowsi university web server. The study found that actual usage values differ for vendor-provided data and local usage data. Elsevier has got the highest usage degree in searches, sessions and downloads. Statistics also showed that a small number of journals satisfy significant amount of use while the majority of journals were used less frequent and some were never used at all. The users preferred the PDF rather than HTML format. The data in subject profile suggested that the provided e-resources were best suited to certain subjects. There was no correlation between IF and electronic journal use. Monitoring the usage of e-resources gained increasing importance for acquisition policy and budget decisions. The article provided information about local metrics for the six surveyed vendors/publishers, e.g. usage trends, requests per package, cost per use as related to the scientific specialty of the university.

  3. Use and User Perception of Electronic Information Resources: A Case Study of Siva Institute of Frontier Technology, India

    Directory of Open Access Journals (Sweden)

    Velmurugan Chandran

    2013-12-01

    Full Text Available The present study aims to explore the use and user perception of electronic resources in Siva Institute of Frontier Technology, India. A total number of 123 users were taken into account for the study through a questionnaire-based survey method. A well-structured questionnaire was designed and distributed to the selected 200 students and staff members. 123 copies of the questionnaires were returned dully filled in and the overall response rate was 61.50 percent. The questionnaire contained both open- and close-ended questions. The collected data were classified, analyzed, and tabulated by using simple statistical methods. This study covers the impact of electronic resources on students and faculty in their academic pursuit.

  4. How Human Resource Professionals Use Electronic Channels to Communicate CSR : A case study focused on Solvay's French industrial sites

    OpenAIRE

    Fournet, Clara; Pauly, Marissa

    2015-01-01

    Corporate Social Responsibility (CSR) has become a large concern for many companies with the rise of globalization. Oftentimes, companies are encouraged to communicate CSR externally, but not internally. This research focuses upon the internal communication of CSR, specifically how Human Resource (HR) professionals use electronic channels to communicate to employees. The scope of this research is focused solely upon HR professionals within Solvay’s French industrial sites, which produce chemi...

  5. Challenges in the implementation of an electronic surveillance system in a resource-limited setting: Alerta, in Peru

    Directory of Open Access Journals (Sweden)

    Soto Giselle

    2008-11-01

    Full Text Available Abstract Background Infectious disease surveillance is a primary public health function in resource-limited settings. In 2003, an electronic disease surveillance system (Alerta was established in the Peruvian Navy with support from the U.S. Naval Medical Research Center Detachment (NMRCD. Many challenges arose during the implementation process, and a variety of solutions were applied. The purpose of this paper is to identify and discuss these issues. Methods This is a retrospective description of the Alerta implementation. After a thoughtful evaluation according to the Centers for Disease Control and Prevention (CDC guidelines, the main challenges to implementation were identified and solutions were devised in the context of a resource-limited setting, Peru. Results After four years of operation, we have identified a number of challenges in implementing and operating this electronic disease surveillance system. These can be divided into the following categories: (1 issues with personnel and stakeholders; (2 issues with resources in a developing setting; (3 issues with processes involved in the collection of data and operation of the system; and (4 issues with organization at the central hub. Some of the challenges are unique to resource-limited settings, but many are applicable for any surveillance system. For each of these challenges, we developed feasible solutions that are discussed. Conclusion There are many challenges to overcome when implementing an electronic disease surveillance system, not only related to technology issues. A comprehensive approach is required for success, including: technical support, personnel management, effective training, and cultural sensitivity in order to assure the effective deployment of an electronic disease surveillance system.

  6. M3D project for simulation studies of plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Park, W.; Belova, E.V.; Fu, G.Y. [Princeton Univ., NJ (United States). Plasma Physics Lab.; Strauss, H.R. [New York Univ., NY (United States); Sugiyama, L.E. [Massachusetts Inst. of Tech., Cambridge, MA (United States)

    1998-12-31

    The M3D (Multi-level 3D) project carries out simulation studies of plasmas of various regimes using multi-levels of physics, geometry, and mesh schemes in one code package. This paper and papers by Strauss, Sugiyama, and Belova in this workshop describe the project, and present examples of current applications. The currently available physics models of the M3D project are MHD, two-fluids, gyrokinetic hot particle/MHD hybrid, and gyrokinetic particle ion/two-fluid hybrid models. The code can be run with both structured and unstructured meshes.

  7. Assembly language programming ARM Cortex-M3

    CERN Document Server

    Mahout, Vincent

    2013-01-01

    ARM designs the cores of microcontrollers which equip most "embedded systems" based on 32-bit processors. Cortex M3 is one of these designs, recently developed by ARM with microcontroller applications in mind. To conceive a particularly optimized piece of software (as is often the case in the world of embedded systems) it is often necessary to know how to program in an assembly language.This book explains the basics of programming in an assembly language, while being based on the architecture of Cortex M3 in detail and developing many examples.It is written for people who have never pr

  8. Tracking the Flow of Resources in Electronic Waste - The Case of End-of-Life Computer Hard Disk Drives.

    Science.gov (United States)

    Habib, Komal; Parajuly, Keshav; Wenzel, Henrik

    2015-10-20

    Recovery of resources, in particular, metals, from waste flows is widely seen as a prioritized option to reduce their potential supply constraints in the future. The current waste electrical and electronic equipment (WEEE) treatment system is more focused on bulk metals, where the recycling rate of specialty metals, such as rare earths, is negligible compared to their increasing use in modern products, such as electronics. This study investigates the challenges in recovering these resources in the existing WEEE treatment system. It is illustrated by following the material flows of resources in a conventional WEEE treatment plant in Denmark. Computer hard disk drives (HDDs) containing neodymium-iron-boron (NdFeB) magnets were selected as the case product for this experiment. The resulting output fractions were tracked until their final treatment in order to estimate the recovery potential of rare earth elements (REEs) and other resources contained in HDDs. The results further show that out of the 244 kg of HDDs treated, 212 kg comprising mainly of aluminum and steel can be finally recovered from the metallurgic process. The results further demonstrate the complete loss of REEs in the existing shredding-based WEEE treatment processes. Dismantling and separate processing of NdFeB magnets from their end-use products can be a more preferred option over shredding. However, it remains a technological and logistic challenge for the existing system.

  9. The impact of electronic healthcare associated infection surveillance software on infection prevention resources: A systematic review of the literature.

    Science.gov (United States)

    Russo, Philip L; Shaban, Ramon Z; MacBeth, Deborough; Carter, Abigail; Mitchell, Brett G

    2017-09-08

    Surveillance of healthcare-associated infections is fundamental for infection prevention. The methods and practices for surveillance have evolved as technology becomes more advanced. The availability of electronic surveillance software (ESS) has increased, and yet adoption of ESS is slow. It is argued that ESS deliver savings through automation, particularly in terms of human resourcing and infection prevention (IP) staff time. This paper describes the findings of a systematic review on the impact of ESS on IP resources. A systematic search was conducted of electronic databases Medline and the Cumulative Index to Nursing and Allied Health Literature published between 1st January 2006 and 31(st) December 2016 with analysis using Newcastle-Ottawa Scale. 2832 articles were reviewed of which 16 studies met the inclusion criteria. IP resources were identified as time undertaken on surveillance. A reduction in IP staff time to undertake surveillance was demonstrated in 13 studies. The reduction proportion ranged from 12.5% - 98.4% (mean 73.9%). The remaining three did not allow for any estimation of the effect in terms of IP staff time. None of the studies demonstrated an increase in IP staff time. The results of this review demonstrate that adopting ESS yield considerable dividends in IP staff time relating to data collection and case ascertainment whilst maintaining high levels of sensitivity and specificity. This has the potential to enable reinvestment into other components of IP to maximise efficient use of scare IP resources. Copyright © 2017. Published by Elsevier Ltd.

  10. HELP (INFORMATION ELECTRONIC RESOURCE "CHRONICLE OF ONU: DATES, FACTS, EVENTS": HISTORY OF UNIVERSITY IN INFORMATION SPACE

    Directory of Open Access Journals (Sweden)

    А. М. Гавриленко

    2016-03-01

    Object of research is the help information resource "The chronicle of the Odessa national university of I. I. Mechnikov: dates, facts, events". The main objective of our article – to state the main methodological bases of creation of information resource. One of advantages of information resource is possibility of continuous updating and replenishment by new information. Main objective of creation of this information resource is systematization of material on stories of the Odessa national university of I. I. Mechnikov from the date of his basis to the present, ensuring interactive access to information on the main dates, the most significant events in life of university. The base of research are sources on the history of university, chronology of historical development, formation of infrastructure, cadres and scientific researches. In information resource the main stages of development, functioning and transformation of the Odessa University are analyzed, information on its divisions is collected. For creation of this information resource in Scientific library the method of work was developed, the main selection criteria of data are allocated. This information resource have practical value for all who is interested in history of university, historians, scientists-researchers of history of science and the city of Odessa.

  11. M3: An Open Model for Measuring Code Artifacts

    NARCIS (Netherlands)

    Izmaylova, A.; Klint, P.; Shahi, A.; Vinju, J.J.

    2013-01-01

    In the context of the EU FP7 project ``OSSMETER'' we are developing an infra-structure for measuring source code. The goal of OSSMETER is to obtain insight in the quality of open-source projects from all possible perspectives, including product, process and community. This is a "white paper" on M3,

  12. Effect of Access to an Electronic Medical Resource on Performance Characteristics of a Certification Examination: A Randomized Controlled Trial.

    Science.gov (United States)

    Lipner, Rebecca S; Brossman, Bradley G; Samonte, Kelli M; Durning, Steven J

    2017-09-05

    Electronic resources are increasingly used in medical practice. Their use during high-stakes certification examinations has been advocated by many experts, but whether doing so would affect the capacity to differentiate between high and low abilities is unknown. To determine the effect of electronic resources on examination performance characteristics. Randomized controlled trial. Medical certification program. 825 physicians initially certified by the American Board of Internal Medicine (ABIM) who passed the Internal Medicine Certification examination or sat for the Internal Medicine Maintenance of Certification (IM-MOC) examination in 2012 to 2015. Participants were randomly assigned to 1 of 4 conditions: closed book using typical or additional time, or open book (that is, UpToDate [Wolters Kluwer]) using typical or additional time. All participants took the same modified version of the IM-MOC examination. Primary outcomes included item difficulty (how easy or difficult the question was), item discrimination (how well the question differentiated between high and low abilities), and average question response time. Secondary outcomes included examination dimensionality (that is, the number of factors measured) and test-taking strategy. Item response theory was used to calculate question characteristics. Analysis of variance compared differences among conditions. Closed-book conditions took significantly less time than open-book conditions (mean, 79.2 seconds [95% CI, 78.5 to 79.9 seconds] vs. 110.3 seconds [CI, 109.2 to 111.4 seconds] per question). Mean discrimination was statistically significantly higher for open-book conditions (0.34 [CI, 0.32 to 0.35] vs. 0.39 [CI, 0.37 to 0.41] per question). A strong single dimension showed that the examination measured the same factor with or without the resource. Only 1 electronic resource was evaluated. Inclusion of an electronic resource with time constraints did not adversely affect test performance and did not change

  13. Understanding intention to use electronic information resources: A theoretical extension of the technology acceptance model (TAM).

    Science.gov (United States)

    Tao, Donghua

    2008-11-06

    This study extended the Technology Acceptance Model (TAM) by examining the roles of two aspects of e-resource characteristics, namely, information quality and system quality, in predicting public health students' intention to use e-resources for completing research paper assignments. Both focus groups and a questionnaire were used to collect data. Descriptive analysis, data screening, and Structural Equation Modeling (SEM) techniques were used for data analysis. The study found that perceived usefulness played a major role in determining students' intention to use e-resources. Perceived usefulness and perceived ease of use fully mediated the impact that information quality and system quality had on behavior intention. The research model enriches the existing technology acceptance literature by extending TAM. Representing two aspects of e-resource characteristics provides greater explanatory information for diagnosing problems of system design, development, and implementation.

  14. Building and Managing Electronic Resources in Digital Era in India with Special Reference to IUCAA and NIV, Pune: A Comparative Case Study

    Science.gov (United States)

    Sahu, H. K.; Singh, S. N.

    2015-04-01

    This paper discusses and presents a comparative case study of two libraries in Pune, India, Inter-University Centre for Astronomy and Astrophysics and Information Centre and Library of National Institute of Virology (Indian Council of Medical Research). It compares how both libraries have managed their e-resource collections, including acquisitions, subscriptions, and consortia arrangements, while also developing a collection of their own resources, including pre-prints and publications, video lectures, and other materials in an institutional repository. This study illustrates how difficult it is to manage electronic resources in a developing country like India, even though electronic resources are used more than print resources. Electronic resource management can be daunting, but with a systematic approach, various problems can be solved, and use of the materials will be enhanced.

  15. Print and Electronic Resources: Usage Statistics at Guru Gobind Singh Indraprastha University Library

    Science.gov (United States)

    Kapoor, Kanta

    2010-01-01

    Purpose: The purpose of this paper is to quantify the use of electronic journals in comparison with the print collections in the Guru Gobind Singh Indraprastha University Library. Design/methodology/approach: A detailed analysis was made of the use of lending services, the Xerox facility and usage of electronic journals such as Science Direct,…

  16. Print and Electronic Resources: Usage Statistics at Guru Gobind Singh Indraprastha University Library

    Science.gov (United States)

    Kapoor, Kanta

    2010-01-01

    Purpose: The purpose of this paper is to quantify the use of electronic journals in comparison with the print collections in the Guru Gobind Singh Indraprastha University Library. Design/methodology/approach: A detailed analysis was made of the use of lending services, the Xerox facility and usage of electronic journals such as Science Direct,…

  17. Intention to use and actual use of electronic information resources: further exploring Technology Acceptance Model (TAM).

    Science.gov (United States)

    Tao, Donghua

    2009-11-14

    Following up a previous study that examined public health students' intention to use e-resources for completing research paper assignments, the present study proposed two models to investigate whether or not public health students actually used the e-resources they intended to use and whether or not the determinants of intention to use predict actual use of e-resources. Focus groups and pre- and post-questionnaires were used to collect data. Descriptive analysis, data screening, and Structural Equation Modeling (SEM) techniques were used for data analysis. The study found that the determinants of intention-to-use significantly predict actual use behavior. Direct impact of perceived usefulness and indirect impact of perceived ease of use to both behavior intention and actual behavior indicated the importance of ease of use at the early stage of technology acceptance. Non-significant intention-behavior relationship prompted thoughts on the measurement of actual behavior and multidimensional characteristics of the intention construct.

  18. M3与M5的MICM鉴别

    Institute of Scientific and Technical Information of China (English)

    索翠平; 李寅; 赵霞

    2003-01-01

    @@ 急性早幼粒细胞自血病(M3型,acute promyelocytic leukemia,APL)和急性单核细胞白血病(M5型,acute monocytic leukemia,AMOL)同属于急性非淋巴细胞白血病.二者在临床与形态上均有相似之处,特别是细颗粒型急性早幼粒细胞白血病(M3b)在形态上更易被误诊为急性单核细胞白血病.但二者的治疗与预后却有很大的区别.在此,结合MICM分型原则对二者加以鉴别,以免造成误诊,导致不应有的后果.

  19. MendelWeb: An Electronic Science/Math/History Resource for the WWW.

    Science.gov (United States)

    Blumberg, Roger B.

    This paper describes a hypermedia resource, called MendelWeb that integrates elementary biology, discrete mathematics, and the history of science. MendelWeb is constructed from Gregor Menders 1865 paper, "Experiments in Plant Hybridization". An English translation of Mendel's paper, which is considered to mark the birth of classical and…

  20. QR Codes as Finding Aides: Linking Electronic and Print Library Resources

    Science.gov (United States)

    Kane, Danielle; Schneidewind, Jeff

    2011-01-01

    As part of a focused, methodical, and evaluative approach to emerging technologies, QR codes are one of many new technologies being used by the UC Irvine Libraries. QR codes provide simple connections between print and virtual resources. In summer 2010, a small task force began to investigate how QR codes could be used to provide information and…

  1. Electronic resources at the University of Sharjah medical library: an investigation of students' information-seeking behavior.

    Science.gov (United States)

    Boumarafi, Behdja

    2010-10-01

    Electronic information is becoming prevalent worldwide, and its use is growing exponentially as more and more users are recognizing the potential that it offers in terms of access and delivery. However, with the introduction of new tools for e-information searching and retrieval, users have to readjust their information-seeking behavior to cope with the corresponding changes. The University of Sharjah library is steadily increasing its investment in e-resources to offer ubiquitous access to the growing body of literature in areas that interest the community it serves. This study reports the findings of a survey conducted to investigate the information-seeking behavior of medical students at the medical library. Results showed evidence of use of e-resources, but they did not explicitly establish that some of the major problems mentioned by participants did hinder the information searches of the respondents. An extensive literature review sets the background for the study.

  2. 图书馆电子信息资源利用效果评价研究%Study on Utilization Effect Evaluation of Library Electronic Information Resources

    Institute of Scientific and Technical Information of China (English)

    晋晓强; 贺培风; 何忠印

    2012-01-01

    This paper discusses utilization effect of electronic information resources combining with the characteristics of electronic information resources, makes evaluation system of library electronic information resource utilization effect from three aspects : the library, the users and the data providers, hoping for providing valuable reference for the efficient use of library electronic resources.%本文结合电子信息资源的特性对电子信息资源的利用进行初步探讨,从图书馆、用户和数据服务商三个角度构建图书馆电子信息资源利用效果的评价体系,希望能为图书馆电子信息资源的高效利用提供参考。

  3. Divergent evolution of the M3A family of metallopeptidases in plants.

    Science.gov (United States)

    Kmiec, Beata; Teixeira, Pedro F; Murcha, Monika W; Glaser, Elzbieta

    2016-07-01

    Plants, as stationary organisms, have developed mechanisms allowing them efficient resource reallocation and a response to changing environmental conditions. One of these mechanisms is proteome remodeling via a broad peptidase network present in various cellular compartments including mitochondria and chloroplasts. The genome of the model plant Arabidopsis thaliana encodes as many as 616 putative peptidase-coding genes organized in 55 peptidase families. In this study, we describe the M3A family of peptidases, which comprises four members: mitochondrial and chloroplastic oligopeptidase (OOP), cytosolic oligopeptidase (CyOP), mitochondrial octapeptidyl aminopeptidase 1 (Oct1) and plant-specific protein of M3 family (PSPM3) of unknown function. We have analyzed the evolutionary conservation of M3A peptidases across plant species and the functional specialization of the three distinct subfamilies. We found that the subfamily-containing OOP and CyOP-like peptidases, responsible for oligopeptide degradation in the endosymbiotic organelles (OOP) or in the cytosol (CyOP), are highly conserved in all kingdoms of life. The Oct1-like peptidase subfamily involved in pre-protein maturation in mitochondria is conserved in all eukaryotes, whereas the PSPM3-like protein subfamily is strictly conserved in higher plants only and is of unknown function. Specific characteristics within PSPM3 sequences, i.e. occurrence of a N-terminal transmembrane domain and amino acid changes in distal substrate-binding motif, distinguish PSPM3 proteins from other members of M3A family. We performed peptidase activity measurements to analyze the role of substrate-binding residues in the different Arabidopsis M3A paralogs. © 2016 Scandinavian Plant Physiology Society.

  4. Structure and dynamics of the M3 muscarinic acetylcholine receptor

    Energy Technology Data Exchange (ETDEWEB)

    Kruse, Andrew C.; Hu, Jianxin; Pan, Albert C.; Arlow, Daniel H.; Rosenbaum, Daniel M.; Rosemond, Erica; Green, Hillary F.; Liu, Tong; Chae, Pil Seok; Dror, Ron O.; Shaw, David E.; Weis, William I.; Wess, Jürgen; Kobilka, Brian K. (Stanford); (NIH); (D.E. Shaw); (Hanyang); (UTSMC)

    2012-03-01

    Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subtypes (M1-M5) share a high degree of sequence homology, they show pronounced differences in G-protein coupling preference and the physiological responses they mediate. Unfortunately, despite decades of effort, no therapeutic agents endowed with clear mAChR subtype selectivity have been developed to exploit these differences. We describe here the structure of the G{sub q/11}-coupled M3 mAChR ('M3 receptor', from rat) bound to the bronchodilator drug tiotropium and identify the binding mode for this clinically important drug. This structure, together with that of the G{sub i/o}-coupled M2 receptor, offers possibilities for the design of mAChR subtype-selective ligands. Importantly, the M3 receptor structure allows a structural comparison between two members of a mammalian GPCR subfamily displaying different G-protein coupling selectivities. Furthermore, molecular dynamics simulations suggest that tiotropium binds transiently to an allosteric site en route to the binding pocket of both receptors. These simulations offer a structural view of an allosteric binding mode for an orthosteric GPCR ligand and provide additional opportunities for the design of ligands with different affinities or binding kinetics for different mAChR subtypes. Our findings not only offer insights into the structure and function of one of the most important GPCR families, but may also facilitate the design of improved therapeutics targeting these critical receptors.

  5. The boundary RSOS \\mathcal{M}(3,5) model

    CERN Document Server

    Deeb, Omar El

    2015-01-01

    We consider the critical non-unitary minimal model {\\cal M}(3,5) with integrable boundaries. We analyze the patterns of zeros of the eigenvalues of the transfer matrix and then determine the spectrum of the critical theory through the Thermodynamic Bethe Ansatz (TBA) equations. We derive these equations for all excitations by solving, the TBA functional equation satisfied by the transfer matrices of the associated A_{4} RSOS lattice model of Forrester and Baxter in Regime III, then determine their corresponding energies. The excitations are classified in terms of (m,n) systems.

  6. 3000m3/h cutter-suction dredge

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ In October 2004, the Fumin 9 3000 m3/h cutter-suction dredge co-designed by the Dutch IHC and Guangzhou Wenchong Shipyard went through a dock usability test and a 25 meter clean water test. The dredge is the largest of its kind in China, and the most advanced and most efficient cutter-suction dredge in the world. The IHC was responsible for the design of the ship till its working design was taken over by Guangzhou Wenchong Shipyard, the builder of the dredge, who had started its construction on October 23, 2003.

  7. Hydraulic supports for polishing TMT M3MP

    Science.gov (United States)

    Hu, Haifei; Qi, Erhui; Cole, Glen; Hu, Haixiang; Luo, Xiao; Ford, Virginia; Zhang, Xuejun

    2016-10-01

    For polishing the ultra-thin TMT M3MP, a polishing support system with 18 hydraulic supports (HS) is introduced. This work focuses on the designing and testing of these HSs. Firstly the design concept of HS system is discussed; then mechanical implementation of the HS structure is carried out, with special consideration of fluid cycling, work pressurization and the weight component. Afterward the piping installation and the de-gas process for the working fluid are implemented. Pressurization and stiffness are well checked before system integration for the single HS unit. Finally the support system is integrated for the polishing process.

  8. An Exploratory study on the use of LibAnswers to Resolve, Track and Monitor Electronic Resources Issues: The KAUST Library experience

    KAUST Repository

    Ramli, Rindra M.

    2017-05-03

    An Exploratory study on KAUST library use of LibAnswers in resolving electronic resources questions received in LibAnswers. It describes the findings of the questions received in LibAnswers. The author made suggestions based on the findings to improve the reference services in responding to e-resources questions.

  9. Eavesdropping on Electronic Guidebooks: Observing Learning Resources in Shared Listening Environments.

    Science.gov (United States)

    Woodruff, Allison; Aoki, Paul M.; Grinter, Rebecca E.; Hurst, Amy; Szymanski, Margaret H.; Thornton, James D.

    This paper describes an electronic guidebook, "Sotto Voce," that enables visitors to share audio information by eavesdropping on each others guidebook activity. The first section discusses the design and implementation of the guidebook device, key aspects of its user interface, the design goals for the audio environment, the eavesdropping…

  10. Electronic Resources in a Next-Generation Catalog: The Case of WorldCat Local

    Science.gov (United States)

    Shadle, Steve

    2009-01-01

    In April 2007, the University of Washington Libraries debuted WorldCat Local (WCL), a localized version of the WorldCat database that interoperates with a library's integrated library system and fulfillment services to provide a single-search interface for a library's physical and electronic content. This brief will describe how WCL incorporates a…

  11. Equalizing Access to Electronic Networked Resources: A Model for Rural Libraries in the United States.

    Science.gov (United States)

    Senkevitch, Judith J.; Wolfram, Dietmar

    1994-01-01

    Provides an overview of the current state of networking technology in rural libraries and describes a model for educating rural librarians in accessing electronic networks. Topics discussed include information needs in rural libraries; telecommunications technology access in rural areas; and examples of services to enhance information access.…

  12. Hot Electron Diagnostic in a Solid Laser Target by K-Shell Lines Measurement from Ultra-Intense Laser-Plasma Interactions R=1.06 (micron)m, 3x10 W/cm -2(less than or equal to) 500 J

    Energy Technology Data Exchange (ETDEWEB)

    Yasuike, K.; Wharton, K.B.; Key, M.; Hatchett, S.; Snavely, R.

    2000-07-27

    Characterization of hot electron production (a conversion efficiency from laser energy into electrons) from ultra intense laser-solid target interaction by observing molybdenum (Mo) K{beta} as well as K{alpha} emissions from a buried fluorescence tracer layer in the targets has been done. The experiments used 1.06 {micro}m laser light with an intensity of from 2 x 10{sup 18} up to 3 x 10{sup 20} W cm{sup -2} (20-0.5 ps pulse width) and an on target laser energy of 280-500 J. The conversion efficiency from the laser energy into the energy, carried by hot electrons, has been estimated to be {approx}50% for the 0.5 ps shots at an on-target laser intensity of 3 x 10{sup 20} W cm{sup -2}, which increased from {approx}30% at 1 x 10{sup 19} W cm{sup -2} 5 ps shots and {approx} 12% at 2 x 10{sup 18} W cm{sup -2} 20 ps shots.

  13. Preference and Use of Electronic Information and Resources by Blind/Visually Impaired in NCR Libraries in India

    Directory of Open Access Journals (Sweden)

    Shailendra Kumar

    2013-06-01

    Full Text Available This paper aims to determine the preference and use of electronic information and resources by blind/visually impaired users in the leading National Capital Region (NCR libraries of India. Survey methodology has been used as the basic research tool for data collection with the help of questionnaires. The 125 in total users surveyed in all the five libraries were selected randomly on the basis of willingness of the users with experience of working in digital environments to participate in the survey. The survey results were tabulated and analyzed with descriptive statistics methods using Excel software and 'Stata version 11'. The findings reveal that ICT have a positive impact in the lives of people with disabilities as it helps them to work independently and increases the level of confidence among them. The Internet is the most preferred medium of access to information among the majority of blind/visually impaired users. The 'Complexity of content available on the net' is found as the major challenge faced during Internet use by blind users of NCR libraries. 'Audio books on CDs/DVDs and DAISY books' are the most preferred electronic resources among the majority of blind/visually impaired users. This study will help the library professionals and organizations/institutions serving people with disabilities to develop effective library services for blind/visually impaired users in the digital environment on the basis of findings on information usage behavior in the study.

  14. Collaboration in electronic resource provision in university libraries: SHEDL, a Scottish case study

    OpenAIRE

    Kidd, T

    2009-01-01

    This case study examines the growth of collaboration among Scottish higher education institutions. Following a summary of the work of the Scottish Confederation of University and Research Libraries (SCURL), more detailed information is provided on collaboration in the fields of acquisition, licensing, selection, and purchasing. Some of the UK background is outlined, relating to NESLi2 in particular, in order to illuminate the options within Scotland. The origins of negotiations on electronic ...

  15. Internet and electronic resources for inflammatory bowel disease: a primer for providers and patients.

    Science.gov (United States)

    Fortinsky, Kyle J; Fournier, Marc R; Benchimol, Eric I

    2012-06-01

    Patients with inflammatory bowel disease (IBD) are increasingly turning to the Internet to research their condition and engage in discourse on their experiences. This has resulted in new dynamics in the relationship between providers and their patients, with misinformation and advertising potentially presenting barriers to the cooperative patient-provider partnership. This article addresses important issues of online IBD-related health information and social media activity, such as quality, reliability, objectivity, and privacy. We reviewed the medical literature on the quality of online information provided to IBD patients, and summarized the most commonly accessed Websites related to IBD. We also assessed the activity on popular social media sites (such as Facebook, Twitter, and YouTube), and evaluated currently available applications for use by IBD patients and providers on mobile phones and tablets. Through our review of the literature and currently available resources, we developed a list of recommended online resources to strengthen patient participation in their care by providing reliable, comprehensive educational material.

  16. 针对MCU应用的Cortex-M3

    Institute of Scientific and Technical Information of China (English)

    费浙平

    2005-01-01

    传统上MCU领域一直由4/8位架构占据了主导地位,部分采用16位架构,而32位才刚起步,在多数人印象中它还是一种奢侈的高端应用。但近几年这种情况已有了很大变化,越来越多的设计采用32位MCU架构,而ARMCotex—M3的面世也为32位MCU应用带来更多可能。

  17. Granulometric composition study of mineral resources using opto-electronic devices and Elsieve software system

    Directory of Open Access Journals (Sweden)

    Kaminski Stanislaw

    2016-01-01

    Full Text Available The use of mechanical sieves has a great impact on measurement results because occurrence of anisometric particles causes undercounting the average size. Such errors can be avoided by using opto-electronic measuring devices that enable measurement of particles from 10 μm up to a few dozen millimetres in size. The results of measurement of each particle size fraction are summed up proportionally to its weight with the use of Elsieve software system and for every type of material particle-size distribution can be obtained. The software allows further statistical interpretation of the results. Beam of infrared radiation identifies size of particles and counts them precisely. Every particle is represented by an electronic impulse proportional to its size. Measurement of particles in aqueous suspension that replaces the hydrometer method can be carried out by using the IPS L analyser (range from 0.2 to 600 μm. The IPS UA analyser (range from 0.5 to 2000 μm is designed for measurement in the air. An ultrasonic adapter enables performing measurements of moist and aggregated particles from 0.5 to 1000 μm. The construction and software system allow to determine second dimension of the particle, its shape coefficient and specific surface area. The AWK 3D analyser (range from 0.2 to 31.5 mm is devoted to measurement of various powdery materials with subsequent determination of particle shape. The AWK B analyser (range from 1 to 130 mm measures materials of thick granulation and shape of the grains. The presented method of measurement repeatedly accelerates and facilitates study of granulometric composition.

  18. 试论图书馆电子资源与纸本资源的协调发展%The coordinated development of library electronic resources and paper resources

    Institute of Scientific and Technical Information of China (English)

    冯雷

    2012-01-01

      纸本资源和电子资源属于公共图书馆文献资源中两个非常重要的资源类型,纸本资源和电子资源的协调发展在图书馆的可持续发展过程中起着非常重要的作用。本文对如何实现图书馆电子资源和纸本资源之间的协调发展进行了探讨,希望能够为图书馆文献资源的管理提供一些参考。%  The paper and electronic resources are two very important types of literature resources of public libraries, the coordinated development of the paper and electronic resources play a very important role in the sustainable development process of the library. This article discusses how to realize the coordinated development of library electronic resources and paper resources, hope to provide some reference for library literature resource management.

  19. On the Development of Electronic Resources and Paper Resources%关于电子资源与纸本资源协调发展的思考和建议

    Institute of Scientific and Technical Information of China (English)

    王军武

    2012-01-01

    In recent years, a large number of electronic resources was introduced to the libraries, which has become an im- portant component of library resource system. However, there are also a lot of hot debates about the following issues, such as how to build a traditional paper resources, how to deal with the relationship between paper resources and electronic resources, how to build a library resources development system, etc. These problems also confused many librarians who are building resources in the library. With the combination with the opinions from some experts, research scholars, the paper proposed some guiding principles to deal with the relationship between electronic resources and paper resources. Taking all the aspects into consideration, such as the concepts of the library, the funding of the resources, the policies and structure of the library, cooperative development, the paper also proposes some measures for the development of electronic resources and paper resources.%在复合图书馆环境下,如何协调发展电子资源与纸本资源是图书馆界专家、学者研究和探讨的热点问题,也是许多图书馆工作者在文献资源建设实践中十分困惑的问题。文章结合有关专家、学者的研究成果及图书馆的相关案例,概述了电子资源与纸本资源协调发展应遵循的指导性原则,并从馆藏理念、经费投入、馆藏政策、馆藏结构、合作发展、服务利用等几个方面提出了协调发展电子资源与纸本资源的若干举措。

  20. Green Supply Chain Collaboration for Fashionable Consumer Electronics Products under Third-Party Power Intervention—A Resource Dependence Perspective

    Directory of Open Access Journals (Sweden)

    Jiuh-Biing Sheu

    2014-05-01

    Full Text Available Under third-party power intervention (TPPI, which increases uncertainty in task environments, complex channel power interplays and restructuring are indispensable among green supply chain members as they move toward sustainable collaborative relationships for increased viability and competitive advantage. From the resource dependence perspective, this work presents a novel conceptual model to investigate the influence of political and social power on channel power restructuring and induced green supply chain collaboration in brander-retailer bidirectional green supply chains of fashionable consumer electronics products (FCEPs. An FCEP refers to the consumer electronics product (e.g., personal computers, mobile phones, computer notebooks, and game consoles with the features of a well-known brand associated, a short product lifecycle, timely and fashionable design fit for market trends, and quick responsiveness to the variations of market demands. The proposed model is tested empirically using questionnaire data obtained from retailers in the FCEP brander-retailer distribution channels. Analytical results reveal that as an extension of political and social power, TPPI positively affects the reciprocal interdependence of dyadic members and reduces power asymmetry, thereby enhancing the collaborative relationship of dyadic members and leading to improved green supply chain performance. Therein, reciprocal interdependence underlying collaborative relationship is the key to reducing the external environmental uncertainties in the TPPI context.

  1. Electronic medical record data to identify variables associated with a fibromyalgia diagnosis: importance of health care resource utilization

    Directory of Open Access Journals (Sweden)

    Masters ET

    2015-03-01

    Full Text Available Elizabeth T Masters,1 Jack Mardekian,1 Birol Emir,1 Andrew Clair,1 Max Kuhn,2 Stuart L Silverman,31Pfizer, Inc., New York, NY, 2Pfizer, Inc., Groton, CT, 3Cedars-Sinai Medical Center, Los Angeles, CA, USABackground: Diagnosis of fibromyalgia (FM is often challenging. Identifying factors associated with an FM diagnosis may guide health care providers in implementing appropriate diagnostic and management strategies.Methods: This retrospective study used the de-identified Humedica electronic medical record (EMR database to identify variables associated with an FM diagnosis. Cases (n=4,296 were subjects ≥18 years old with ≥2 International Classification of Diseases, Ninth Revision (ICD-9 codes for FM (729.1 ≥30 days apart during 2012, associated with an integrated delivery network, with ≥1 encounter with a health care provider in 2011 and 2012. Controls without FM (no-FM; n=583,665 did not have the ICD-9 codes for FM. Demographic, clinical, and health care resource utilization variables were extracted from structured EMR data. Univariate analysis identified variables showing significant differences between the cohorts based on odds ratios (ORs.Results: Consistent with FM epidemiology, FM subjects were predominantly female (78.7% vs 64.5%; P<0.0001 and slightly older (mean age 53.3 vs 52.7 years; P=0.0318. Relative to the no-FM cohort, the FM cohort was characterized by a higher prevalence of nearly all evaluated comorbidities; the ORs suggested a higher likelihood of an FM diagnosis (P<0.0001, especially for musculoskeletal and neuropathic pain conditions (OR 3.1 for each condition. Variables potentially associated with an FM diagnosis included higher levels of use of specific health care resources including emergency-room visits, outpatient visits, hospitalizations, and medications. Units used per subject for emergency-room visits, outpatient visits, hospitalizations, and medications were also significantly higher in the FM cohort (P<0

  2. Survey on User Satisfaction of Electronic Resources in University Libraries%高校图书馆电子资源用户满意度调查

    Institute of Scientific and Technical Information of China (English)

    陈姚竹; 马东

    2011-01-01

    通过分析影响用户对图书馆电子资源利用的因素,以美国顾客满意度指数模型为基础,提出关于各个因素的测量指标,对高校图书馆电子资源用户满意度进行测量。%Through analyzing the influencing factors on utilizing library electronic resources, based on the model of American customer satisfaction index, the paper puts forward corresponding measurement indexes, and then measures the user satisfaction on electronic resources of university library

  3. Hemopoietic tissue in newts flown aboard Foton M3

    Science.gov (United States)

    Domaratskaya, Elena I.; Almeida, Eduardo; Butorina, Nina N.; Nikonova, Tatyana M.; Grigoryan, Eleonora N.; Poplinskaya, Valentina A.; Souza, Kenneth; Skidmore, Mike

    The effect of 12-day spaceflight aboard the Foton-M3 biosatellite on the hematopoietic tissue of P. waltl newts was studied. These animals used at the same time in regeneration experiments after lens and tail tip amputation. In flight and synchronous groups there were performed video recording, temperature and radiation monitoring and continuous contact (via skin) with thymidine analog BrdU. We took differential blood counts and assessed histologically the liver in the flight (F), basal (BC) and synchronous (SC)control groups of animals. In the peripheral blood, we identified neutrophils, eosinophils, basophils, lymphocytes, and monocytes. Lymphocytes (L) and neutrophils (N) prevailed, accounting for about 60 and 20% of white blood cells, respectively. The spaceflight had no apparent effect on the differential blood count in the F group: neither the L and N contents nor the maturing to mature N - ratio differed from those in the control groups. No significant differences between F, SC and BC groups were observed with respect to the structure of hematopoietic areas and the liver morphology. As in Foton-M2, BrdU labeled cells revealed in blood as well as in the hemopoietic areas of the liver. However, in previous experiments performed at satellites Bion-10 and Foton-M2 the changes in peripheral blood contents were registered in operated F newts, and we supposed it could be the result of additive effects of spaceflight factors and stimulation of reparative potency and stress due to surgical operation. Possibly, the temperature conditions also may provide some influence on blood cell content of newts that belong to poikilothermic animals. Thus, in present experiment F and SC groups were reared in the same temperature regims, whereas it was nearly 3o C differences between SC and F groups exposed on Foton-M2. At the same time as it was found in experiments on Bion-11 and Foton-M2 spaceflight factors did not affect on differential blood counts of intact non

  4. Development of an electronic medical record based alert for risk of HIV treatment failure in a low-resource setting.

    Directory of Open Access Journals (Sweden)

    Nancy Puttkammer

    Full Text Available BACKGROUND: The adoption of electronic medical record systems in resource-limited settings can help clinicians monitor patients' adherence to HIV antiretroviral therapy (ART and identify patients at risk of future ART failure, allowing resources to be targeted to those most at risk. METHODS: Among adult patients enrolled on ART from 2005-2013 at two large, public-sector hospitals in Haiti, ART failure was assessed after 6-12 months on treatment, based on the World Health Organization's immunologic and clinical criteria. We identified models for predicting ART failure based on ART adherence measures and other patient characteristics. We assessed performance of candidate models using area under the receiver operating curve, and validated results using a randomly-split data sample. The selected prediction model was used to generate a risk score, and its ability to differentiate ART failure risk over a 42-month follow-up period was tested using stratified Kaplan Meier survival curves. RESULTS: Among 923 patients with CD4 results available during the period 6-12 months after ART initiation, 196 (21.2% met ART failure criteria. The pharmacy-based proportion of days covered (PDC measure performed best among five possible ART adherence measures at predicting ART failure. Average PDC during the first 6 months on ART was 79.0% among cases of ART failure and 88.6% among cases of non-failure (p<0.01. When additional information including sex, baseline CD4, and duration of enrollment in HIV care prior to ART initiation were added to PDC, the risk score differentiated between those who did and did not meet failure criteria over 42 months following ART initiation. CONCLUSIONS: Pharmacy data are most useful for new ART adherence alerts within iSanté. Such alerts offer potential to help clinicians identify patients at high risk of ART failure so that they can be targeted with adherence support interventions, before ART failure occurs.

  5. M3-learning - Exploring mobile multimedia microblogging learning

    Directory of Open Access Journals (Sweden)

    Carmen Holotescu

    2011-12-01

    Full Text Available In the context in which the new frontier of Web 2.0 is marked out by the use of mobile devices anywhere, anytime, by anyone and anything, our paper aims at valorizing the mobility parameters of the Cirip.eu platform in order to integrate the microblogging technology in higher education, for the purpose of increasing knowledge and learning in authentic mobile learning environments. As an innovation for the mobile learning through microblogging, we mention the following elements:•On a technological level: localize / join mobile groups, access content and OERs, share opinions, work collaboratively on multimedia objects, participate in polls / quizzes, receive / send updates via SMS, create / manage mobile PLEs, recover password via SMS;On a pedagogical level: develop multimedia educational resources / learning objects by using mobile technologies specific for different subject areas to be teached with microblogging.Thus, the aim of our experiment is not only to provide a general overview / a framework for using microblogging through mobile technologies, but also a way to enhance teaching and learning in formal university courses and to present mobile microblogging learning benefits, opportunities, limits and risks.

  6. Transport coefficients of black MQGP M3-branes

    Energy Technology Data Exchange (ETDEWEB)

    Dhuria, Mansi [Physical Research Laboratory, Theoretical Physics Division, Ahmedabad (India); Misra, Aalok [Indian Institute of Technology, Department of Physics, Roorkee, Uttaranchal (India)

    2015-01-01

    The Strominger-Yau-Zaslow (SYZ) mirror, in the 'delocalised limit' of Becker et al. (Nucl Phys B 702:207, 2004), of N D3-branes, M fractional D3-branes and N{sub f} flavour D7-branes wrapping a non-compact four-cycle in the presence of a black hole (BH) resulting in a non-Kahler resolved warped deformed conifold (NKRWDC) in Mia et al. (Nucl Phys B 839:187, 2010), was carried out in Dhuria and Misra (JHEP 1311:001, 2013) and resulted in black M3- branes. There are two parts in our paper. In the first we show that in the 'MQGP' limit discussed in Dhuria and Misra (JHEP 1311:001, 2013) a finite g{sub s} (and hence expected to be more relevant to QGP), finite g{sub s}M, N{sub f}, g{sub s}{sup 2}MN{sub f} and very large g{sub s}N, and very small (g,M{sup 2})/(N), we have the following. (i) The uplift, if valid globally (like Dasgupta et al., Nucl Phys B 755:21, 2006) for fractional D3 branes in conifolds, asymptotically goes to M5-branes wrapping a two-cycle (homologously a (large) integer sum of two-spheres) in AdS{sub 5} x M{sub 6}. (ii) Assuming the deformation parameter to be larger than the resolution parameter, by estimating the five SU(3) structure torsion (τ) classes W{sub 1,2,3,4,5} we verify that τ element of W{sub 5} in the large-r limit, implying the NKRWDC reduces to a warped Kahler deformed conifold. (iii) The local T{sup 3} of Dhuria and Misra (JHEP 1311:001, 2013) in the large-r limit satisfies the same conditions as the maximal T{sup 2}-invariant special Lagrangian three-cycle of T*S{sup 3} of Ionel and Min-OO (J Math 52(3), 2008), partly justifying use of SYZ-mirror symmetry in the ''delocalised limit'' of Becker et al. (Nucl Phys B 702:207, 2004) in Dhuria and Misra (JHEP 1311:001, 2013). In the second part of the paper, by either integrating out the angular coordinates of the non-compact four-cycle which a D7-brane wraps around, using the Ouyang embedding, in the DBI action of a D7-brane evaluated at infinite

  7. The BRIGHTEN Program: Implementation and Evaluation of a Program to Bridge Resources of an Interdisciplinary Geriatric Health Team via Electronic Networking

    Science.gov (United States)

    Emery, Erin E.; Lapidos, Stan; Eisenstein, Amy R.; Ivan, Iulia I.; Golden, Robyn L.

    2012-01-01

    Purpose: To demonstrate the feasibility of the BRIGHTEN Program (Bridging Resources of an Interdisciplinary Geriatric Health Team via Electronic Networking), an interdisciplinary team intervention for assessing and treating older adults for depression in outpatient primary and specialty medical clinics. The BRIGHTEN team collaborates "virtually"…

  8. The module of methodical support in system of electronic educational resources as the innovative element of the modern maintenance of formation

    Directory of Open Access Journals (Sweden)

    Ольга Николаевна Крылова

    2009-06-01

    Full Text Available The article introduces some results of research, which were devoted to evaluation of tearches' mobility to introduce innovations in the contents of education. The author considers innovative potential of modules of the methodical support for system of electronic educational resources.

  9. Charting a Course through CORAL: Texas A&M University Libraries' Experience Implementing an Open-Source Electronic Resources Management System

    Science.gov (United States)

    Hartnett, Eric; Beh, Eugenia; Resnick, Taryn; Ugaz, Ana; Tabacaru, Simona

    2013-01-01

    In 2010, after two previous unsuccessful attempts at electronic resources management system (ERMS) implementation, Texas A&M University (TAMU) Libraries set out once again to find an ERMS that would fit its needs. After surveying the field, TAMU Libraries selected the University of Notre Dame Hesburgh Libraries-developed, open-source ERMS,…

  10. The BRIGHTEN Program: Implementation and Evaluation of a Program to Bridge Resources of an Interdisciplinary Geriatric Health Team via Electronic Networking

    Science.gov (United States)

    Emery, Erin E.; Lapidos, Stan; Eisenstein, Amy R.; Ivan, Iulia I.; Golden, Robyn L.

    2012-01-01

    Purpose: To demonstrate the feasibility of the BRIGHTEN Program (Bridging Resources of an Interdisciplinary Geriatric Health Team via Electronic Networking), an interdisciplinary team intervention for assessing and treating older adults for depression in outpatient primary and specialty medical clinics. The BRIGHTEN team collaborates "virtually"…

  11. Electronic Information Resources (EIR Adoption in Private University Libraries: The Moderating Effect of Productivity and Relative Advantage on Perceived Usefulness

    Directory of Open Access Journals (Sweden)

    Izuagbe, Roland

    2016-03-01

    Full Text Available The study tested a hybrid model with constructs drawn from the Technology Acceptance Model (TAM and Diffusion of Innovation (DOI theory in order to examine the moderating effect of productivity and relative advantage (RA on perceived usefulness (PU vis-à-vis electronic information resources (EIR adoption in private university libraries in Ogun and Osun States of Nigeria. The descriptive research design was adopted in the study. The population consisted of 61 (55.0% librarians and 50 (45.0% library officers (totaling 116—100% in Babcock University, Bells University, Covenant University, Bowen University, Oduduwa University, and Redeemer's University. Purposive sampling procedure was adopted after which total enumeration was used since the total population is small. The questionnaire was used for data collection. Of the 116 copies of the questionnaire administered, 111 (95.7% were found usable. The instrument was structured based on a 4-point Likert agreement scale of Strongly Agree, Agree, Disagree, and Strongly Disagree. Data were analyzed using descriptive statistics like tables of frequency counts and percentage. The findings revealed that productivity and relative advantage are significant moderators of perceived usefulness of EIR adoption in private university libraries in Ogun and Osun States, Nigeria.

  12. High temperature EPR study of the M3Fe4V6O24 (M = Cu, Zn, Mg and Mn

    Directory of Open Access Journals (Sweden)

    Guskos Niko

    2016-09-01

    Full Text Available Electron paramagnetic resonance (EPR spectra of M3Fe4V6O24 (M = Cu, Zn, Mg and Mn compounds in high temperature range (293 K to 493 K have been investigated. The role of magnetic (Cu, Mn and non-magnetic (Zn, Mg ions in M3Fe4V6O24 structure in formation of magnetic resonance spectra was studied. Temperature dependence of EPR parameters: resonance field, linewidth and integrated intensity were examined. Similarities and differences in temperature behavior of these parameters has been discussed in terms of different relaxation mechanisms and magnetic interactions in the spin systems. An important role of additional magnetic ions (M = Mn or Cu in the M3Fe4V6O24 structure has been identified and its consequences considered.

  13. M3(Au,Ge)19 and M(3.25)(Au,Ge)18 (M = Ca, Yb): distinctive phase separations driven by configurational disorder in cubic YCd6-type derivatives.

    Science.gov (United States)

    Lin, Qisheng; Corbett, John D

    2010-05-17

    Exploratory syntheses in the M-Au-Ge (M = Ca, Yb) systems have led to the discovery of two cleanly separated non-stoichiometric phases M(3)Au(approximately 14.4)Ge(approximately 4.6) (I) and M(3.25)Au(approximately 12.7)Ge(approximately 5.3) (II). Single crystal X-ray studies reveal that both (space group Im3) feature body-centered-cubic packing of five-shell multiply endohedral clusters that resemble those in the parent YCd(6) (= Y(3)Cd(18)) and are akin to approximate phases in other quasicrystal systems. However, differences resulting from various disorders in these are distinctive. The innermost cluster in the M(3)Au(approximately 14.4)Ge(approximately 4.6) phase (I) remains a disordered tetrahedron, as in the YCd(6) parent. In contrast, its counterpart in the electron-richer M(3.25)Au(approximately 12.7)Ge(approximately 5.3) phase (II) is a "rattling" M atom. The structural differentiations between I and II exhibit strong correlations between lattice parameters, cluster sizes, particular site occupancies, and valence electron counts.

  14. Effects of Modulating M3 Muscarinic Receptor Activity on Azoxymethane-Induced Liver Injury in Mice

    OpenAIRE

    2013-01-01

    Previously, we reported that azoxymethane (AOM)-induced liver injury is robustly exacerbated in M3 muscarinic receptor (M3R)-deficient mice. We used the same mouse model to test the hypothesis that selective pharmacological modulation of M3R activity regulates the liver injury response. Initial experiments confirmed that giving a selective M3R antagonist, darifenacin, to AOM-treated mice mimicked M3R gene ablation. Compared to vehicle controls, mice treated with the M3R antagonist had reduced...

  15. Reactor Dosimetry Applications Using RAPTOR-M3G:. a New Parallel 3-D Radiation Transport Code

    Science.gov (United States)

    Longoni, Gianluca; Anderson, Stanwood L.

    2009-08-01

    The numerical solution of the Linearized Boltzmann Equation (LBE) via the Discrete Ordinates method (SN) requires extensive computational resources for large 3-D neutron and gamma transport applications due to the concurrent discretization of the angular, spatial, and energy domains. This paper will discuss the development RAPTOR-M3G (RApid Parallel Transport Of Radiation - Multiple 3D Geometries), a new 3-D parallel radiation transport code, and its application to the calculation of ex-vessel neutron dosimetry responses in the cavity of a commercial 2-loop Pressurized Water Reactor (PWR). RAPTOR-M3G is based domain decomposition algorithms, where the spatial and angular domains are allocated and processed on multi-processor computer architectures. As compared to traditional single-processor applications, this approach reduces the computational load as well as the memory requirement per processor, yielding an efficient solution methodology for large 3-D problems. Measured neutron dosimetry responses in the reactor cavity air gap will be compared to the RAPTOR-M3G predictions. This paper is organized as follows: Section 1 discusses the RAPTOR-M3G methodology; Section 2 describes the 2-loop PWR model and the numerical results obtained. Section 3 addresses the parallel performance of the code, and Section 4 concludes this paper with final remarks and future work.

  16. A Study on the Model for Resources Matching of Electronic Bartering%电子易货资源匹配模型研究

    Institute of Scientific and Technical Information of China (English)

    吴剑云; 张嵩

    2012-01-01

    By exchanging idle goods and services, electronic bartering can help enterprises solve dull sale problems, shortage of funds, overstocks and other problems without sufficient cash. Relying on the Internet and the e-commerce platform, electronic bartering removes the traditional bartering limitations, greatly expands the trading object and range, improves the transaction efficiency, and provides additional channels for economic development. How to promote more successful barters among multiple barterers? A key factor is the matching of barter resources. Focusing on the automatic matching of resources in the electronic barter, this paper proposes a network model to help maximize resources matching and provide recommendation information for barter participants, thereby raising the transaction rate and making the barter market prosperous.According to the type and quantity of barter resources, barter market can be divided into two types. In the first type, the supply and demand of the barter market is related to the same type of resources and each barterer owns only one type of resource. In the second type, the supply and demand of the barter market is linked to many types of resources and each barterer owns multiple resources to be exchanged. The first case has been resolved in the relevant document by using the graph theory to solve digraph circuits. This paper is interested in studying the second type of barter. Suppose the barter market has m barterers and n resources. Each barterer owns diverse types of barter resources, and is interested in other types of resources. The barterer a will provide other barterers his own resources only if he gets the resources he needs from the barterer b. Note that each of the bartered resource is regarded as having equal value to any other resources. The main objective is to maximize the number of resources that are bartered.Next, this paper proposes a math model of automatic resources matching by systematically analyzing resource

  17. Exception Processing of Cortex-M3%Cortex-M3的异常处理机制研究

    Institute of Scientific and Technical Information of China (English)

    方安平; 蔡俊宇

    2009-01-01

    详细阐述Cortex-M3异常的分类、优先级、进入和退出,以及在Cortex-M3异常处理机制中使用的新技术--迟到(late-arriving)和尾链(tail-chaining);最后,比较Cortex-M3和ARM7异常控制机制的区别,并量化分析迟到和尾链技术在异常处理中的优越性.

  18. The Use and Maintenance of University Library Electronic Resources%浅议大学图书馆电子资源的利用与维护

    Institute of Scientific and Technical Information of China (English)

    马鹏飞; 熊豫玲

    2011-01-01

    随着科学技术的飞速发展,高新信息技术的广泛应用,大学图书馆的工作内容和方法也面临新的挑战,为了使用户更好的利用大学图书馆的电子资源,提高电子资源利用率,实现大学图书馆数字化,本文主要从电子资源的利用和维护方面进行探讨。%With the rapid development of science and technology,the extensive application of high-tech information technology, University of content and methods of library work is also facing new challenges in order to make better use of university library users to electronic resources,improve the utilization of electronic resources to achieve the University Library digital,paper, from the use of electronic resources and maintenance were discussed.

  19. Theoretical study of neutral and charged Sc{sub n{<=}2}-(benzene){sub m{<=}3} clusters

    Energy Technology Data Exchange (ETDEWEB)

    Maynez-Rojas, Miguel; Castro, Miguel, E-mail: castro@quetzal.pquim.unam.mx [Universidad Nacional Autonoma de Mexico, Departamento de Fisica y Quimica Teorica, DEPg. Facultad de Quimica (Mexico)

    2013-01-15

    Interactions of benzene molecules with scandium atoms, Sc{sub n{<=}2}-(C{sub 6}H{sub 6}){sub m{<=}3}, in the gas phase were studied by means of density functional theory. All-electron calculations were performed using the B3LYP hybrid functional in concert with 6-311+G(d,p) orbital basis sets for the Sc, C, and H atoms. Multiple-decker sandwich (MDS) structures are identified as the ground states for Sc{sub n{<=}2}-(C{sub 6}H{sub 6}){sub m{<=}3}, where the ligands are attached to the metal through Sc-C bonding, formed between the 3d electrons and the {pi}-clouds of the benzene rings. Significant distortion is produced on the absorbed benzene molecules by the metal-ligand bonding. Rice ball structures also appeared, but they were found at higher energies, in such a way that essentially MDS isomers may emerge in the molecular beams. Even the low number of valence electrons (3d{sup 2}4s{sup 1}) of the Sc atom; sextuple coordinations are formed, but they show different Sc-C bond lengths, diminishing the symmetry of neutral and charged clusters. The estimated ionization energies, in near agreement with experimental data, and electron affinities, suggest delocalization of the valence electrons through the network of 3d-{pi} bonds of Sc{sub 1,2}-(C{sub 6}H{sub 6}){sub m{<=}3}. The binding energies decrease with the absorption of more benzene molecules, and in some cases increase as more metal atoms are added to the cluster.

  20. Comparative study of AISI M3:2 high speed steel produced through different techniques of manufacturing; Estudo comparativo de acos rapidos AISI M3:2 produzidos por diferentes processos de fabricacao

    Energy Technology Data Exchange (ETDEWEB)

    Araujo Filho, Oscar Olimpio de

    2006-07-01

    In this work AISI M3:2 high speed steels obtained through different techniques of manufacturing, submitted to the same heat treatment procedure were evaluated by measuring their mechanical properties of transverse rupture strength and hardness. Sinter 23 obtained by hot isostatic pressing (HIP), VWM3C obtained by the conventional route and a M3:2 high speed steel obtained by cold compaction of water atomized powders and vacuum sintered with and without the addition of a small quantity of carbon were evaluated after the same heat treatment procedure. The vacuum sintered M3:2 high speed steel can be an alternative to the more expensive high speed steel produced by hot isostatic pressing and with similar properties presented by the conventional one. The characterization of the vacuum sintered M3:2 high speed steel was performed by measuring the densities of the green compacts and after the sintering cycle. The sintering produced an acceptable microstructure and densities near to the theoretical. The transverse rupture strength was evaluated by means of three point bending tests and the hardness by means of Rockwell C and Vickers tests. The technique of scanning electronic microscopy (SEM) was used to evaluate the microstructure and to establish a relation with the property of transverse rupture strength. The structure was determined by means of X-ray diffraction (XRD) patterns and the retained austenite was detected to all the conditions of heat treatment. The main contribution of this work is to establish a relation between the microstructure and the mechanical property of transverse rupture strength and to evaluate the AISI M3:2 vacuum sintered high speed steel as an alternative to the similar commercial high speed steels. (author)

  1. Barriers to electronic access and delivery of educational information in resource constrained public schools: a case of Greater Tubatse Municipality

    CSIR Research Space (South Africa)

    Pholotho, T

    2016-05-01

    Full Text Available Information and Communication Technologies (ICTs) are capable of expanding access to quality education, educational resources and provide teachers with new skills. Nevertheless, a majority of rural public schools have limited ICTs, mainly due...

  2. Electronic Grey Literature in Accelerator Science and Its Allied Subjects : Selected Web Resources for Scientists and Engineers

    CERN Document Server

    Rajendiran, P

    2006-01-01

    Grey literature Web resources in the field of accelerator science and its allied subjects are collected for the scientists and engineers of RRCAT (Raja Ramanna Centre for Advanced Technology). For definition purposes the different types of grey literature are described. The Web resources collected and compiled in this article (with an overview and link for each) specifically focus on technical reports, preprints or e-prints, which meet the main information needs of RRCAT users.

  3. 电子资源许可使用的发展与创新%The Development and Innovation of the Use of the Electronic Resource License

    Institute of Scientific and Technical Information of China (English)

    王军

    2012-01-01

      电子资源许可使用在我国发展时间较短,在其建立过程中还存在许可定价、购买模式、馆际互借以及电子资源的长期保存许可方式等难题。电子资源许可使用的发展与创新,需要根据用户需求制定发展战略,建立图书馆的读者监督管理制度和数字化资源服务制度,规范文献编目制度等,以提高电子信息资源与图书馆信息资源的使用效果和广泛的使用需求%  It's been a short time since the use of electronic resource licenses has developed in China; in addition, many problems ap-pear in the establishment process in terms of license pricing, purchase pattern, inter-library loan and long-term preservation ways of electronic resources. In order to develop and innovate the use of the license, libraries should develop strategies in accordance with the users' needs, establish a reader supervision system and a digital resource service system, and normalize the document cataloging sys-tem to enhance the utilization effect and meet the extensive demand for electronic and library information resources.

  4. Different Characteristics of the Bright Branches of the Globular Clusters M3 and M13

    CERN Document Server

    Cho, D H; Jeon, Y B; Sim, K J; Cho, Dong-Hwan; Lee, Sang-Gak; Jeon, Young-Beom; Sim, Kyung Jin

    2005-01-01

    We carried out wide-field BVI CCD photometric observations of the GCs M3 and M13 using the BOAO 1.8 m telescope equipped with a 2K CCD. We present CMDs of M3 and M13. We have found AGB bumps at V = 14.85 for M3 at V = 14.25 for M13. It is found that AGB stars in M3 are more concentrated near the bump, while those in M13 are scattered along the AGB sequence. We identified the RGB bump of M3 at V = 15.50 and that of M13 at V = 14.80. We have estimated the ratios R and R2 for M3 and M13 and found that of R for M3 is larger than that for M13 while R2's for M3 and M13 are similar when only normal HB stars are used in R and R2 for M13. However, we found that R's for M3 and M13 are similar while R2 for M3 is larger than that for M13 when all the HB stars are included in R and R2 for M13. We have compared the observed RGB LFs of M3 and M13 with the theoretical RGB LF of Bergbusch & VandenBerg at the same radial distances from the cluster centers as used in R and R2 for M3 and M13. We found "extra stars" belonging...

  5. Second Parameter Effects in and between M3 and Palomar 3

    CERN Document Server

    Catelan, M; Ferraro, F R

    2001-01-01

    We study the globular clusters M3 and Palomar 3 as a "second parameter (2ndP) pair," showing that: i) M3 has a surprisingly strong *internal* 2ndP; ii) The dispersion in mass on the Pal 3 horizontal branch (HB) is intrinsically very small, leading to the most apparent differences in HB morphology between M3 and Pal 3; iii) Ignoring the difference in HB mass dispersion between M3 and Pal 3, their relative HB types can be accounted for by a fairly small difference in age, of order 0.5-1 Gyr.

  6. Design Essentials of 80 m3 Diluted Acetaldehyde Storage Tank%浅谈80 m3稀乙醛储槽设计要点

    Institute of Scientific and Technical Information of China (English)

    白春山; 刘文元

    2009-01-01

    Combination 80 m3 thin acetaldehyde tank design, the paper focused on low-pressure tank-top cans bearing ring, tank walls, tank top and anchor set design and the method of calculating and comparing the general design of storage tanks were introduced.%结合80 m3稀乙醛储槽的设计,着重介绍低压储罐罐顶承压环、罐壁、罐顶以及锚栓设置的设计及其计算方法,并与一般储罐设计进行比较.

  7. Effects of Modulating M3 Muscarinic Receptor Activity on Azoxymethane-Induced Liver Injury in Mice

    Science.gov (United States)

    Khurana, Sandeep; Jadeja, Ravirajsinh; Twadell, William; Cheng, Kunrong; Rachakonda, Vikrant; Saxena, Neeraj; Raufman, Jean-Pierre

    2013-01-01

    Previously, we reported that azoxymethane (AOM)-induced liver injury is robustly exacerbated in M3 muscarinic receptor (M3R)-deficient mice. We used the same mouse model to test the hypothesis that selective pharmacological modulation of M3R activity regulates the liver injury response. Initial experiments confirmed that giving a selective M3R antagonist, darifenacin, to AOM-treated mice mimicked M3R gene ablation. Compared to vehicle controls, mice treated with the M3R antagonist had reduced survival and increased liver nodularity and fibrosis. We next assessed AOM-induced liver injury in mice treated with a selective M3R agonist, pilocarpine. After pilocarpine treatment, stimulation of post-M3R signaling in the liver was evidenced by ERK and AKT activation. In contrast to the damaging effects of the M3R antagonist, administering pilocarpine to AOM-treated mice significantly attenuated hepatic stellate cell activation, collagen deposition, bile ductule proliferation, and liver fibrosis and nodularity. As anticipated from these findings, livers from pilocarpine-treated mice exhibited reduced expression of key players in fibrosis (α1 collagen, α-smooth muscle actin, TGF-β1, PGDF, TGF-β1R, PGDFR) and decreased mRNA levels for molecules that regulate extracellular matrix formation (TIMP-1, TIMP-2, MMP-2, MMP-13). Cleaved caspase-3, nitrotyrosine and BrdU immunostaining provided evidence that pilocarpine treatment reduced hepatocyte apoptosis and oxidative stress, while increasing hepatocyte proliferation. Collectively, these findings identify several downstream mechanisms whereby M3R activation ameliorates toxic liver injury. These novel observations provide a proof-of-principle that selectively stimulating M3R activation to prevent or diminish liver injury is a therapeutic strategy worthy of further investigation. PMID:23707755

  8. Clinician‐selected Electronic Information Resources do not Guarantee Accuracy in Answering Primary Care Physicians’ Information Needs. A review of: McKibbon, K. Ann, and Douglas B. Fridsma. “Effectiveness of Clinician‐selected Electronic Information Resources for Answering Primary Care Physicians’ Information Needs.” Journal of the American Medical Informatics Association 13.6 (2006: 653‐9.

    Directory of Open Access Journals (Sweden)

    Martha Ingrid Preddie

    2008-03-01

    Full Text Available Objective – To determine if electronic information resources selected by primary care physicians improve their ability to answer simulated clinical questions.Design – An observational study utilizing hour‐long interviews and think‐aloud protocols.Setting – The offices and clinics of primary care physicians in Canada and the United States.Subjects – Twenty‐five primary care physicians of whom 4 were women, 17 were from Canada, 22 were family physicians,and 24 were board certified.Methods – Participants provided responses to 23 multiple‐choice questions. Each physician then chose two questions and looked for the answers utilizing information resources of their own choice. The search processes, chosen resources and search times were noted. These were analyzed along with data on the accuracy of the answers and certainties related to the answer to each clinical question prior to the search.Main results – Twenty‐three physicians sought answers to 46 simulated clinical questions. Utilizing only electronic information resources, physicians spent a mean of 13.0 (SD 5.5 minutes searching for answers to the questions, an average of 7.3(SD 4.0 minutes for the first question and 5.8 (SD 2.2 minutes to answer the second question. On average, 1.8 resources were utilized per question. Resources that summarized information, such as the Cochrane Database of Systematic Reviews, UpToDate and Clinical Evidence, were favored 39.2% of the time, MEDLINE (Ovid and PubMed 35.7%, and Internet resources including Google 22.6%. Almost 50% of the search and retrieval strategies were keyword‐based, while MeSH, subheadings and limiting were used less frequently. On average, before searching physicians answered 10 of 23 (43.5% questions accurately. For questions that were searched using clinician‐selected electronic resources, 18 (39.1% of the 46 answers were accurate before searching, while 19 (42.1% were accurate after searching. The difference of

  9. Scale-up of industrial biodiesel production to 40 m3using a liquid lipase formulation

    DEFF Research Database (Denmark)

    Price, Jason; Nordblad, Mathias; Martel, Hannah H.

    2016-01-01

    In this work, we demonstrate the scale-up from an 80 L fed-batch scale to 40 m3 along with the design of a 4 m3continuous process for enzymatic biodiesel production catalysed by NS-40116 (a liquid formulation of a modified Thermomyces lanuginosus lipase). Based on the analysis of actual pilot pla...

  10. Residual stress in a M3:2 PM high speed steel; effect of mechanical loading

    DEFF Research Database (Denmark)

    Højerslev, Christian; Odén, Magnus; Carstensen, Jesper V.;

    2001-01-01

    X-ray lattice strains were investigated in an AISI M3:2 PM high-speed steel in the as heat treated condition and after exposure to alternating mechanical load. The volume changes during heat treatment were monitored with dilatometry. Hardened and tempered AISI M3:2 steel consists of tempered lath...

  11. Conceived on the City Electronic Waste Resource Mana oement Model%城市电子废弃物资源化管理模式构想

    Institute of Scientific and Technical Information of China (English)

    熊贵琍; 余涛

    2012-01-01

    Investigated e- waste collection system the investigation, the whereabouts and electronic waste disposal in Httizhou city, the paper analyzed the Huizhou city e- waste collection and disposal of a series of problems, combined with the actual, conceived urban electronic waste resources management mode.%通过对惠州市电子废弃物收集体系组成、去向以及电子废弃物处置方式的调查,分析惠州市电子废弃物收集和处置存在的一系列问题,结合实际提出了城市电子废弃物资源化管理模式的初步构想。

  12. Accessibility and Use of Web-Based Electronic Resources by Physicians in a Psychiatric Institution in Nigeria

    Science.gov (United States)

    Oduwole, Adebambo Adewale; Oyewumi, Olatundun

    2010-01-01

    Purpose: This study aims to examine the accessibility and use of web-based electronic databases on the Health InterNetwork Access to Research Initiative (HINARI) portal by physicians in the Neuropsychiatric Hospital, Aro--a psychiatry health institution in Nigeria. Design/methodology/approach: Collection of data was through the use of a three-part…

  13. On M3-transition rates in selected odd-mass nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Lombard, R.J. E-mail: lombard@ipno.in2p3.fr; Vdovin, A.I.; Shirikova, N.Yu.; Sushkov, A.V

    2003-06-02

    The reduced probabilities of M3 transitions are studied in five deformed and three spherical or near-spherical odd-mass nuclei. In deformed nuclei, the states linked by M3 transitions are predominantly of single-quasiparticle nature and the calculations are performed taking into account the single-quasiparticle as well as core-polarization terms in the M3-operator. Whereas in {sup 159}Ho, {sup 175}Yb, and {sup 179}Hf the ratio between theoretical and experimental B(M3) values range from 0.5 to 1.4, the situation is much worse in neutron deficient nuclides {sup 179}W and {sup 183}Pt where the theory used can not explain a very sharp drop of the B(M3) values. In the soft nuclei {sup 121}Cs and {sup 207}Po the states connected by M3 transitions are treated as 'quasiparticle x phonon' states. In {sup 113}Sn, the small 'quasiparticle x phonon' components are not sufficient to compensate vanishing contribution of the dominant quasiparticle component, which shares {delta}l forbidden transitions. Thus, on the whole theoretical description of B(M3) with the present simple models seems to be unsatisfactory. It constitutes a challenging problem both at the level of the nuclear structure and the transition operator.

  14. Share and share alike: encouraging the reuse of academic resources through the Scottish electronic Staff Development Library

    Directory of Open Access Journals (Sweden)

    Lorna M. Campbell

    2001-12-01

    Full Text Available The Scottish electronic Staff Development Library (http://www.sesdl.scotcit.acuk is an ongoing collaborative project involving the Universities of Edinburgh, Paisley and Strathclyde which has been funded by SHEFC as part of their current ScotCIT Programme (http:llwww.scotcit.ac.uk. This project is being developed in response to the increasing demand for flexible, high-quality staff development materials.

  15. COOLING METHOD OF SILUMINA CASTINGS AK15M3 AT VERTICAL CENTRIFUGAL CASTING

    Directory of Open Access Journals (Sweden)

    V. Yu. Stecenko

    2013-01-01

    Full Text Available The way of cooling of castings from silumin AK15M3 is developed at the vertical centrifugal casting, enabling to receive bimetallic blanks with high-disperse eutectic and hypereutectic microstructures and minimal allowance for machining.

  16. Complete Genome Sequence of the Novel Leech Symbiont Mucinivorans hirudinis M3T

    OpenAIRE

    Nelson, Michael C.; Bomar, Lindsey; Graf, Joerg

    2015-01-01

    Mucinivorans hirudinis M3T was isolated from the digestive tract of the medicinal leech, Hirudo verbana, and is the type species of a new genus within the Rikenellaceae. Here, we report the complete annotated genome sequence of this bacterium.

  17. Complete Genome Sequence of the Novel Leech Symbiont Mucinivorans hirudinis M3T.

    Science.gov (United States)

    Nelson, Michael C; Bomar, Lindsey; Graf, Joerg

    2015-02-05

    Mucinivorans hirudinis M3(T) was isolated from the digestive tract of the medicinal leech, Hirudo verbana, and is the type species of a new genus within the Rikenellaceae. Here, we report the complete annotated genome sequence of this bacterium.

  18. 重庆高校图书馆电子文献资源建设现状及对策%The Present Situation and Countermeasure of Electronic Literature Resources Construction about Chongqing University Library

    Institute of Scientific and Technical Information of China (English)

    刘子辉; 彭渝; 陈强; 吴晓英

    2014-01-01

    In the information society, Electronic document resources are very important for library development and the school's teaching and research. The university library should pay more at ention to the construction of electronic document resources. Through the survey of the electronic document resources in Chongqing, We have mastered the distribution of electronic document resources, analyzed the existing problems in resource construction, and proposed the related countermeasure. We hope to provide reference for the electronic document resources construction.%在信息社会,电子文献资源对高校图书馆建设、学校的教学与科研都起到非常重要的作用,各高校图书馆应该更加重视电子文献资源的建设。通过对重庆高校图书馆电子文献资源建设情况进行调查,掌握了本地区电子文献资源的分布情况,分析了资源建设中存在的问题,并提出了相关对策,希望为本地区高校图书馆电子文献资源建设提供参考。

  19. Posttranslational modifications of human M3 muscarinic acetylcholine receptor: zooming in its functional implications

    OpenAIRE

    Romero Fernández, Wilber

    2011-01-01

    The human M3 muscarinic acetylcholine receptor (M3R) regulates many important physiological roles in the central and peripheral nervous systems, and it is involved in the pathophysiology of several neurodegenerative and autoimmune diseases, representing attractive potential pharmacological target for intervention. However, the lack of structural information on this receptor hampered the development of new potent antagonist with increased selectivity and lower side effects. Such structural inf...

  20. M3B: A coarse grain model for the simulation of oligosaccharides and their water mixtures.

    Science.gov (United States)

    Goddard, William A.; Cagin, Tahir; Molinero, Valeria

    2003-03-01

    Water and sugar dynamics in concentrated carbohydrate solutions is of utmost importance in food and pharmaceutical technology. Water diffusion in concentrated sugar mixtures can be slowed down many orders of magnitude with respect to bulk water [1], making extremely expensive the simulation of these systems with atomistic detail for the required time-scales. We present a coarse grain model (M3B) for malto-oligosaccharides and their water mixtures. M3B speeds up molecular dynamics simulations about 500-1000 times with respect to the atomistic model while retaining enough detail to be mapped back to the atomistic structures with low uncertainty in the positions. The former characteristic allows the study of water and carbohydrate dynamics in supercooled and polydisperse mixtures with characteristic time scales above the nanosecond. The latter makes M3B well suited for combined atomistic-mesoscale simulations. We present the parameterization of M3B force field for water and a family of technologically relevant glucose oligosaccharides, the alpha-(1->4) glucans. The coarse grain force field is completely parameterized from atomistic simulations to reproduce the density, cohesive energy and structural parameters of amorphous sugars. We will show that M3B is capable to describe the helical character of the higher oligosaccharides, and that the water structure in low moisture mixtures shows the same features obtained with the atomistic and M3B models. [1] R Parker, SG Ring: Carbohydr. Res. 273 (1995) 147-55.

  1. σ-Aromatic cyclic M3(+) (M = Cu, Ag, Au) clusters and their complexation with dimethyl imidazol-2-ylidene, pyridine, isoxazole, furan, noble gases and carbon monoxide.

    Science.gov (United States)

    Pan, Sudip; Saha, Ranajit; Mandal, Subhajit; Chattaraj, Pratim K

    2016-04-28

    The σ-aromaticity of M3(+) (M = Cu, Ag, Au) is analyzed and compared with that of Li3(+) and a prototype σ-aromatic system, H3(+). Ligands (L) like dimethyl imidazol-2-ylidene, pyridine, isoxazole and furan are employed to stabilize these monocationic M3(+) clusters. They all bind M3(+) with favorable interaction energy. Dimethyl imidazol-2-ylidene forms the strongest bond with M3(+) followed by pyridine, isoxazole and furan. Electrostatic contribution is considerably more than that of orbital contribution in these M-L bonds. The orbital interaction arises from both L → M σ donation and L ← M back donation. M3(+) clusters also bind noble gas atoms and carbon monoxide effectively. In general, among the studied systems Au3(+) binds a given L most strongly followed by Cu3(+) and Ag3(+). Computation of the nucleus-independent chemical shift (NICS) and its different extensions like the NICS-rate and NICS in-plane component vs. NICS out-of-plane component shows that the σ-aromaticity in L bound M3(+) increases compared to that of bare clusters. The aromaticity in pyridine, isoxazole and furan bound Au3(+) complexes is quite comparable with that in the recently synthesized Zn3(C5(CH3)5)3(+). The energy gap between the highest occupied molecular orbital and the lowest unoccupied molecular orbital also increases upon binding with L. The blue-shift and red-shift in the C-O stretching frequency of M3(CO)3(+) and M3(OC)3(+), respectively, are analyzed through reverse polarization of the σ- and π-orbitals of CO as well as the relative amount of OC → M σ donation and M → CO π back donation. The electron density analysis is also performed to gain further insight into the nature of interaction.

  2. New M+, M3+-arsenates – the framework structures of AgM3+(HAsO42 (M3+ = Al, Ga and M+GaAs2O7 (M+ = Na, Ag

    Directory of Open Access Journals (Sweden)

    Karolina Schwendtner

    2017-05-01

    Full Text Available The crystal structures of hydrothermally synthesized silver(I aluminium bis[hydrogen arsenate(V], AgAl(HAsO42, silver(I gallium bis[hydrogen arsenate(V], AgGa(HAsO42, silver gallium diarsenate(V, AgGaAs2O7, and sodium gallium diarsenate(V, NaGaAs2O7, were determined from single-crystal X-ray diffraction data collected at room temperature. The first two compounds are representatives of the MCV-3 structure type known for KSc(HAsO42, which is characterized by a three-dimensional anionic framework of corner-sharing alternating M3+O6 octahedra (M = Al, Ga and singly protonated AsO4 tetrahedra. Intersecting channels parallel to [101] and [110] host the Ag+ cations, which are positionally disordered in the Ga compound, but not in the Al compound. The hydrogen bonds are relatively strong, with O...O donor–acceptor distances of 2.6262 (17 and 2.6240 (19 Å for the Al and Ga compounds, respectively. The two diarsenate compounds are representatives of the NaAlAs2O7 structure type, characterized by an anionic framework topology built of M3+O6 octahedra (M = Al, Ga sharing corners with diarsenate groups, and M+ cations (M = Ag hosted in the voids of the framework. Both structures are characterized by a staggered conformation of the As2O7 groups.

  3. 3 800 m3耙吸挖泥船的HVAC设计%HVAC design for a 3 800 m3 trailing suction dredger

    Institute of Scientific and Technical Information of China (English)

    戴菁; 赵骊; 陈维茂

    2007-01-01

    挖泥船的需求量与日俱增,逐渐形成系列船型.通过介绍3 800 m3耙吸挖泥船的HVAC设计系统,与以往挖泥船型比较,以及用户的评价,指出该船的空调系统设计思想和方法上的优点,为后续船提供了有益的参考.

  4. Selection and Evaluation of Electronic Resources Elektronik Kaynakların Seçimi ve Değerlendirilmesi

    Directory of Open Access Journals (Sweden)

    Doğan Atılgan

    2009-12-01

    Full Text Available Publication boom and issues related to controlling and accession of printed sources have created some problems after World War II. Consequently, publishing industry has encountered the problem of finding possible solution for emerged situation. Industry of electronic publishing has started to improve with the rapid increase of the price of printed sources as well as the problem of publication boom. The first effects of electronic publishing were appeared on the academic and scholarly publications then electronic publishing became a crucial part of all types of publications. As a result of these developments, collection developments and service policies of information centers were also significantly changed. In this article, after a general introduction about selection and evaluation processes of electronic publications, the subscribed databases by a state and a privately owned university in Turkey and their usage were examined. İkinci dünya savaşından sonra görülen yayın patlaması, basılı kaynakların denetim ve erişiminde sorunlar yaşanmasına neden olmuştur. Bu da yayıncılık sektöründe yeni arayışlara yol açmıştır. 1980’li yıllardan sonra basılı yayın fiyatlarındaki hızlı artış da bu etmenlere eklenince elektronik yayıncılık sektörü gelişmeye başlamıştır. Öncelikle bilimsel ve akademik yayınlarla başlayan elektronik yayın günümüzde tüm yayın türlerini kapsamaktadır. Yayıncılıktaki bu gelişim bilgi merkezlerinin derme geliştirme ve hizmet politikalarını da önemli ölçüde değiştirmiştir. Bu çalışmada elektronik yayınların seçim, değerlendirme ve sağlama konularında genel bir girişten sonra bir devlet üniversitesinin bir de özel üniversitenin abone olduğu veritabanları ve bu veri tabanlarının kullanımının değerlendirilmesi yapılmaktadır.

  5. Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice

    NARCIS (Netherlands)

    Kistemaker, Loes E.M.; van Os, Ronald P.; Dethmers-Ausema, Albertina; Bos, I. Sophie T.; Hylkema, Machteld N.; van den Berge, Maarten; Hiemstra, Pieter S; Wess, Jürgen; Meurs, Herman; Kerstjens, Huib A.M.; Gosens, Reinoud

    2015-01-01

    Anticholinergics, blocking the muscarinic M-3 receptor, are effective bronchodilators for patients with chronic obstructive pulmonary disease. Recent evidence from M-3 receptor-deficient mice (M3R-/-) indicates that M-3 receptors also regulate neutrophilic inflammation in response to cigarette smoke

  6. Resources Conditions of Coalbed Methane Districts in China

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The China National Administration of Coal Geology accomplished an assessment of coalbed methane resources of China in 1988. The total amount of coalbed methane resources in China is 14336.944 billion m3,occurring in recoverable coal seams and beneath weathering zones,with coalbed methane content equal to or higher than 4 m3 per ton and buried depths smaller than 2000 m,among which there are 967.51 billion m3 of predicted reserves and 13369.434 billion m3 of future reserves. The resources in coal reservoirs with methane content of more than 8 m3 per ton are 12444.087 billion m3,and those with methane content between 4 to 8 m3 per ton are 1892.856 billion m3. There are 35 districts in which the resources abundance is higher than 150 million m3/km2,49 districts with the abundance between 50 million and 150 million m3/km2,and 31 districts with the abundance less than 50 million m3/km2. There is 9256.078 billion m3 of methane occurring in coal seams with buried depths less than 1500 m,and 5080.866 billion m3 in coal seams with buried depths between 1500 and 2000 m. There are 28 large-scale districts in which coalbed methane resources are more than 100 billions m3,28 medium-scale districts with coalbed methane resources between 20 billion and 100 billion m3 and 59 small-scale districts with resources amount less than 20 billion m3. The Jincheng area is one of the most favourable districts for coalbed methane resources in China.

  7. Design of USB smart card reader based on Cortex-M3%基于Cortex-M3的智能卡USB读卡器设计

    Institute of Scientific and Technical Information of China (English)

    李冬霞; 张雪庆

    2010-01-01

    为了提高智能卡系统的通信速度和中断响应速度,设计了基于Cortex-M3和USB接口的智能卡读卡器系统.设计中采用具有ARM Cortex-M3内核的STM32F103R6T6等芯片进行相关的硬件设计,分别使用Keil和Visual C++6.0进行读卡器固件子系统程序和PC端子系统驱动程序开发,在此基础上,专门设计了测试程序用于测试系统的正确性和有效性.实验结果表明,该智能卡读卡器系统可实现计算机与智能卡的准确,高效通信.

  8. Renovation of stirring system in 300m3 L-lysine fermentor%300m3赖氨酸发酵罐搅拌系统改造

    Institute of Scientific and Technical Information of China (English)

    王远海

    2012-01-01

    以加强传质混合为目的提出300m3赖氨酸发酵罐搅拌系统改造方案,采用计算流体力学(CFD)数值模拟方法分析了搅拌系统轴功率、流型、传质混合能力,成功指导了搅拌系统改造,在电流增大的情况下,平均单罐产量提高2.44t,平均糖酸转化率提高约1个百分点.%To strengthen mass transfer and mixing for purpose, the reform scheme of stirring system in 300m3 L-lysine fermentor was proposed, CFD (Computational Fluid Dynamics) numerical simulation was used in analysing shaft power, flow pattern, mass transfer mixing ability of the stirring system, when current increased, the fermentation yield and L-lysine acid conversion rate of sugar was 2.44t and about 1% higher than the fermentor which not renovated.

  9. M3-receptor activation counteracts opioid-mediated apneusis, but the apneusis per se is not necessarily related to an impaired M3 mechanism in rats.

    Science.gov (United States)

    Niwa, Yuka; Haji, Akira

    2011-11-07

    Morphine slows the respiratory cycle due to a predominant prolongation of inspiration (apneusis) by postponing the spontaneous termination of inspiration (inspiratory off-switching). The present study investigates whether the morphine-induced apneusis results from impairment of cholinergic mechanisms in the central respiratory network. The efferent discharge was recorded from the phrenic nerve in artificially ventilated and anesthetized rats with vagotomy. All drugs were injected intravenously. The phrenic nerve displayed an augmenting discharge during inspiration and arrest of discharge during expiration in normal condition. Administration of morphine (0.3-10.0mg/kg) dose-dependently provoked apneusis characterized by a long-lasting, plateau inspiratory discharge of the phrenic nerve. It shortened the expiratory duration. Subsequent administration of physostigmine (0.1mg/kg) restored the morphine-induced apneusis to eupnea with a partial recovery of the augmenting inspiratory discharge. This modification of physostigmine was blocked by a non-specific muscarinic antagonist scopolamine (3.0mg/kg), leading to re-prolongation of inspiration. A similar antagonism was affected by an antagonist of M3 cholinergic receptors, 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP, 1.0 and 10.0mg/kg) but not by an antagonist of M1 cholinergic receptors, pirenzepine (1.0 and 10.0mg/kg). These results demonstrate that the activation of endogenous M3 cholinergic mechanisms counteracts the morphine-induced apneusis. Copyright © 2011 Elsevier Inc. All rights reserved.

  10. Utility of the electronic information resource UpToDate for clinical decision-making at bedside rounds.

    Science.gov (United States)

    Phua, J; See, K C; Khalizah, H J; Low, S P; Lim, T K

    2012-02-01

    Clinical questions often arise at daily hospital bedside rounds. Yet, little information exists on how the search for answers may be facilitated. The aim of this prospective study was, therefore, to evaluate the overall utility, including the feasibility and usefulness of incorporating searches of UpToDate, a popular online information resource, into rounds. Doctors searched UpToDate for any unresolved clinical questions during rounds for patients in general medicine and respiratory wards, and in the medical intensive care unit of a tertiary teaching hospital. The nature of the questions and the results of the searches were recorded. Searches were deemed feasible if they were completed during the rounds and useful if they provided a satisfactory answer. A total of 157 UpToDate searches were performed during the study period. Questions were raised by all ranks of clinicians from junior doctors to consultants. The searches were feasible and performed immediately during rounds 44% of the time. Each search took a median of three minutes (first quartile: two minutes, third quartile: five minutes). UpToDate provided a useful and satisfactory answer 75% of the time, a partial answer 17% of the time and no answer 9% of the time. It led to a change in investigations, diagnosis or management 37% of the time, confirmed what was originally known or planned 38% of the time and had no effect 25% of the time. Incorporating UpToDate searches into daily bedside rounds was feasible and useful in clinical decision-making.

  11. Adsorption of aromatics on the (111) surface of PtM and PtM3 (M = Fe, Ni) alloys

    Energy Technology Data Exchange (ETDEWEB)

    Hensley, Alyssa; Schneider, Sebastian; Wang, Yong; McEwen, Jean-Sabin

    2015-09-18

    The adsorption of benzene and phenol was studied on PtM and PtM3 (111) surfaces, with M being either Ni or Fe. Under vacuum, the most favorable near surface structures showed an enrichment in Pt over the M species. An analysis of the electronic structure of the metal species in the clean surfaces with different near surface structures was done with the d-band model and showed that the Pt's d-states are significantly shifted away from the Fermi level due to the Pt-M interactions while the M species' d-states were less affected, with Ni's d-band shifting closer to the Fermi level and Fe's d-band shifting away from the Fermi level. The adsorption of aromatics, benzene and phenol, on several near surface structures for the PtM and PtM3 (111) surfaces showed that higher surface M concentrations resulted in a stronger adsorption due to the larger amount of charge transferred between the adsorbate and surface. However, compared to the adsorption of benzene and phenol on monometallic surfaces, the adsorption of these species on the PtM and PtM3 (111) surfaces was significantly weakened. Overall, our results show that the observed behavior of these Pt/Fe and Pt/Ni alloys is similar to that seen for the previously studied Pd/Fe surfaces. Furthermore, balancing the weakly adsorbing Pt surface species with the more strongly interacting Fe or Ni species can lead to the tailored adsorption of aromatics with applications in both hydrodeoxygenation and hydrogenation reactions by increasing the desorption rate of wanted aromatic products.

  12. The application of pentaprism scanning technology on the manufacturing of M3MP

    Science.gov (United States)

    Qi, Erhui; Hu, Haixiang; Hu, Haifei; Cole, Glen; Luo, Xiao; Ford, Virginia; Zhang, Xuejun

    2016-10-01

    The PSS (pentaprism scanning system) has advantages of simple structure, needless of reference flat, be able of on-site testing, etc, it plays an important role in large flat reflective mirror's manufacturing, especially the high accuracy testing of low order aberrations. The PSS system measures directly the slope information of the tested flat surface. Aimed at the unique requirement of M3MP, which is the prototype mirror of the tertiary mirror in TMT (Thirty Meter Telescope) project, this paper analyzed the slope distribution of low order aberrations, power and astigmatism, which is very important in the manufacturing process of M3MP. Then the sample route lines of PSS are reorganized and new data process algorism is implemented. All this work is done to improve PSS's measure sensitivity of power and astigmatism, for guiding the manufacturing process of M3MP.

  13. Muscarinic M3 receptor subtype gene expression in the human heart.

    Science.gov (United States)

    Hellgren, I; Mustafa, A; Riazi, M; Suliman, I; Sylvén, C; Adem, A

    2000-01-20

    The heart is an important target organ for cholinergic function. In this study, muscarinic receptor subtype(s) in the human heart were determined using reverse transcription-polymerase chain reaction. Our results demonstrated muscarinic receptor M2 and M3 subtype RNA in left/right atria/ventricles of donor hearts. Receptor autoradiography analysis using selective muscarinic ligands indicated an absence of M1 receptor subtype in the human heart. The level of muscarinic receptor binding in atria was two to three times greater than in ventricles. Our results suggest that muscarinic receptors in the human heart are of the M2 and M3 subtypes. This is the first report of M3 receptors in the human myocardium.

  14. M3 User's Manual. Version 3.0

    Energy Technology Data Exchange (ETDEWEB)

    Laaksoharju, Marcus (Geopoint AB, Sollentuna (Sweden)); Skaarman, Erik (Abscondo Utveckling, Bromma (Sweden)); Gomez, Javier B. (Univ. of Zaragoza (Spain). Geochemical modelling Group); Gurban, Ioana (3D Terra (Canada))

    2006-07-15

    This report describes the Multivariate Mixing and Mass balance calculations (M3). This new method and computer code is developed to trace the mixing and reaction processes in the groundwater. The aim of the M3 concept is to decode the often hidden and complex information gathered in the groundwater analytical data. The manual presents shortly the theory and practice behind the M3 method. The M3 computer code is also presented and emphasis is put on the reference manual. This includes detailed reference to the M3 program's abilities and limitations, installation procedures and all functions and operations that the program can perform. It also describes sample cases of how the program is used to analyse a test data set. This guide is part of the Help Files distributed together with M3. Two accompanying reports cover other aspects: - Concepts, Methods, and Mathematical Formulation, gives a complete description of the mathematical framework of M3 and introduces concepts and methods useful for the end user. - M3 version 3.0: Verification and Validation, gathers a collection of validation and verification exercises, designed to test each part of M3 code and to build confidence in its methodology. The M3 method has been tested and modified over several years. The development work has been supported by the Swedish Nuclear Fuel and Waste Management Company (SKB). The main test site for the model was the underground Aespoe Hard Rock Laboratory (HRL). The examples used in this manual are from a Aespoe international groundwater modelling co-operation project where one of the tools used was M3. The M3 concept has been applied on the data from SKB's site investigation programme and in data from Canada, Japan, Jordan, Gabon and Finland. The groundwater composition is a result of mixing processes and water-rock interaction. Standard groundwater models based on thermodynamic laws may not be applicable in a normal temperature groundwater system where equilibrium with many

  15. A Discussion of the High Energy Density Primary Battery Employed in the FOTON M3 Mission

    Science.gov (United States)

    Bennetti, A.; Reece, D.; Spurrett, R.; Schautz, M.; Green, K.

    2008-09-01

    In 2005, ABSL Space Products (ABSL) was contracted by QinetiQ to deliver the lithium sulfuryl chloride primary battery system for the FOTON M3 ESA (European Space Agency) mission. FOTON M3 was led by the ESA Directorate of Human Spaceflight & Exploration and carried a number of materials science, fluid physics and biology experiments as well as technology demonstration payloads. A number of the experiments required a very high energy density primary battery power source. This battery was manufactured by ABSL, and the mission was successfully completed in September 2007 following a twelve days orbiting in Low Earth Orbit (LEO).

  16. Development of RT-components for the M-3 Strawberry Harvesting Robot

    Science.gov (United States)

    Yamashita, Tomoki; Tanaka, Motomasa; Yamamoto, Satoshi; Hayashi, Shigehiko; Saito, Sadafumi; Sugano, Shigeki

    We are now developing the strawberry harvest robot called “M-3” prototype robot system under the 4th urgent project of MAFF. In order to develop the control software of the M-3 robot more efficiently, we innovated the RT-middleware “OpenRTM-aist” software platform. In this system, we developed 9 kind of RT-Components (RTC): Robot task sequence player RTC, Proxy RTC for image processing software, DC motor controller RTC, Arm kinematics RTC, and so on. In this paper, we discuss advantages of RT-middleware developing system and problems about operating the RTC-configured robotic system by end-users.

  17. 1500 m3立式圆筒形煤仓有限元计算%Finite Element Calculation of 1 500 m3 Vertical Cylindrical Bunker

    Institute of Scientific and Technical Information of China (English)

    汪志福; 陶保林; 孙文红

    2015-01-01

    Large cylindrical bunker is widely used in oil fired steam injection station project.An analysis of stress strength for the design of a 1 500 m3 vertical cylindrical bunker is given.A large general finite element software ANSYS is used to establish a actual size of the finite element nu-merical model,which connected with a coal bunker tank top,tank walls,bearing,cone bottom, consistent with steel support columns,using powerful border simulation and all kinds of applied load function,in a state filled with water + wind + snow + load cases,to calculate and check the various structural parts of coal bunker.The calculated results show that it has sufficient safe-ty margin and reliability.%大型圆筒式煤仓在油田燃煤注汽站工程中应用广泛,对某1500 m3立式圆筒形煤仓进行了应力强度分析。运用有限元软件 ANSYS 建立了与煤仓罐顶、罐壁、支座连接、锥底、支撑钢架以及立柱实际尺寸相一致的有限元数值计算模型,利用软件的边界模拟和各种荷载施加功能,针对煤仓各结构部分,在充水状态+风载荷+雪载荷+地震载荷工况下进行了应力计算和校核,结果表明,此煤仓具有足够的安全裕度及可靠性。

  18. Metal-organic Kagome lattices M3(2,3,6,7,10,11-hexaiminotriphenylene)2 (M = Ni and Cu): from semiconducting to metallic by metal substitution.

    Science.gov (United States)

    Chen, Shuang; Dai, Jun; Zeng, Xiao Cheng

    2015-02-28

    Motivated by recent experimental synthesis of a semiconducting metal-organic graphene analogue (J. Am. Chem. Soc., 2014, 136, 8859), i.e., Ni3(2,3,6,7,10,11-hexaiminotriphenylene)2 [Ni3(HITP)2], a new Kagome lattice, Cu3(HITP)2, is designed by substituting the coordination of Ni by Cu. Such substitution results in interesting changes in electronic properties of the M3(HITP)2 bulk and two-dimensional (2D) sheets. In Ni3(HITP)2, each Ni atom adopts the dsp(2) hybridization, forming a perfect 2D conjugation, whereas in Cu3(HITP)2, each Cu atom adopts the sp(3) hybridization, resulting in a distorted 2D sheet. The M3(HITP)2 bulks, assembled from M3(HITP)2 sheets via both strong π-π interaction and weak metal-metal interaction, are metallic. However, the 2D Ni3(HITP)2 sheet is a semiconductor with a narrow band gap whereas the 2D Cu3(HITP)2 sheet is a metal. Remarkably, both the 2D M3(HITP)2 Kagome lattices possess Dirac bands in the vicinity of the Fermi level. Additional ab initio molecular dynamics simulations show that both sheets exhibit high thermal stability at elevated temperatures. Our theoretical study offers new insights into tunability of electronic properties for the 2D metal-organic frameworks (MOFs).

  19. HST UV Observations of the Cores of M3 and M13

    CERN Document Server

    Ferraro, F R; Pecci, F F; Cacciari, C; Dorman, B; Rood, R T; Ferraro, Francesco R.; Paltrinieri, Barbara; Pecci, Flavio Fusi; Cacciari, Carla; Dorman, Ben; Rood, Robert T.

    1997-01-01

    We present preliminary results from HST/WFPC2 observations of the central regions of the of the Galactic globular clusters M13 and M3. The clusters are almost identical in most respects including chemical composition, but there are dramatic differences in both the horizontal branch (HB) and blue straggler (BSS) populations. The M13 HB has a long blue tail extending 4.5 mag in V, reaching well below the level of the main sequence turn-off. M3 has no such feature. M3 and M13 are thus an extreme case of the ``second parameter problem'' in HB morphology. Also present in the M13 HB are two gaps similar to those seen in the clusters NGC 6752 and NGC 2808. M3 has a specific frequency of BSS three times larger than that of M13. Our results imply that neither age nor cluster density, two popular second parameter candidates, are likely to be responsible for the observed differences.

  20. Experimental Conditions: SE37_S16_M3_D1 [Metabolonote[Archive

    Lifescience Database Archive (English)

    Full Text Available opes SE37_S16 Blank (80% methanol) SE37_S16_M3 0mg [MassBase ID] MDLC1_43486 SE37_MS1 Metabolites extraction... with 80% methanol and analysis by LC-Orbitrap-MS SE37_DS1 Peak extraction for unlabeled data ...

  1. On the Family of Thue Equation |x3 + mx2y- (m + 3) xy2 + y3 |= k

    Institute of Scientific and Technical Information of China (English)

    XIA Jingbo; CHEN Jianhua; ZHANG Silan

    2006-01-01

    The family of cubic Thue equation which depend on two parameters | x3 + mx2 y- (m+3) xy2 + y3|=k is studied. Using rational approximation, we give a smaller upper bound of the solution of the equation, that is quite better than the present result. Moreover, we study two inequalities |x3 +mx2y- (m+3)xy2 +y3|=k≤2m+3 and |m3 +mm2y- (m+3)my2 + y3 | = k≤(2m+ 3)2 separately. Our result of upper bound make it easy to solve those inequalities by simple method of continuous fraction expansion.

  2. 图书馆纸质资源与电子资源投入比例研究%The research of ratio between traditional and electronics resources in library

    Institute of Scientific and Technical Information of China (English)

    王以婧; 李明

    2012-01-01

    With the popularization of electronic product development,library is no longer the paper-based resources into a single information carrier the pattern,but has formed a paper resource and electronic resources coexist in the new situation.Because the library types of our country,the proportion of input between paper-based resources and other kinds of resources exist difference.This paper will discuss the relationship between the traditional and electronics resources,and also points out the existing problems and the countermeasures.%随着电子产品的普及发展,图书馆已不再以纸质资源为唯一的信息载体,而是形成了纸质资源和电子资源并存的新局面。由于国内图书馆类型的不同,纸质资源与电子资源的配比也会存在差异。通过讨论二者的关系,指出存在的问题及应对之策。

  3. There is a Relationship between Resource Expenditures and Reference Transactions in Academic Libraries. A Review of: Dubnjakovic, A. (2012. Electronic resource expenditure and the decline in reference transaction statistics in academic libraries. Journal of Academic Librarianship, 38(2, 94-100. doi:10.1016/j.acalib.2012.01.001

    Directory of Open Access Journals (Sweden)

    Annie M. Hughes

    2013-03-01

    Full Text Available Objective – To provide an analysis of the impact of expenditures on electronic resourcesand gate counts on the increase or decrease in reference transactions.Design – Analysis of results of existing survey data from the National Center for Educational Statistics (NCES 2006 Academic Library Survey(ALS.Setting – Academic libraries in the United States.Subjects – 3925 academic library respondents.Methods – The author chose to use survey data collected from the 2006 ALS conducted bythe NCES. The survey included data on various topics related to academic libraries, but in the case of this study, the author chose to analyze three of the 193 variables included. The three variables: electronic books expenditure, computer hardware and software, and expenditures on bibliographic utilities, were combined into one variable called electronic resource expenditure. Gate counts were also considered as a variable. Electronic resource expenditure was also split as a variable into three groups: low, medium, and high. Multiple regression analysis and general linear modeling, along with tests of reliability, were employed. Main Results – The author determined that low, medium, and high spenders with regard to electronic resources exhibited differences in gate counts, and gate counts have an effect on reference transactions in any given week. Gate counts tend to not have much of an effect on reference transactions for the higher spenders, and higher spenders tend to have a higher number of reference transactions overall. Low spenders have lower gate counts and also a lower amount of reference transactions.Conclusion – The findings from this study show that academic libraries spending more on electronic resources also tend to have an increase with regard to reference transactions. The author also concludes that library spaces are no longer the determining factor with regard to number of reference transactions. Spending more on electronic resources is

  4. Residual stress in a M3:2 PM high speed steel; effect of mechanical loading

    DEFF Research Database (Denmark)

    Højerslev, Christian; Odén, Magnus; Carstensen, Jesper V.

    2001-01-01

    X-ray lattice strains were investigated in an AISI M3:2 PM high-speed steel in the as heat treated condition and after exposure to alternating mechanical load. The volume changes during heat treatment were monitored with dilatometry. Hardened and tempered AISI M3:2 steel consists of tempered lath...... martensite and the carbides M6C,V8C7 and M23C6. In the as heat treated condition the stress state is triaxial. The primary carbides M6C and V8C7 experience a compressive state of stress. Exposure to an alternating mechanical load, changes the states of stress of V8C7 and tempered martensite, but does...... not appear to change the state of stress in M6C....

  5. The Abundance of Lithium in an AGB Star in the Globular Cluster M3 (NGC 5272)

    CERN Document Server

    Givens, R A

    2016-01-01

    A survey of red giants in the globular cluster M3 with the Hydra multi-object spectrograph on the WIYN 3.5-m telescope indicated a prominent Li I 6707 $\\AA$ feature in the red giant vZ 1050. Follow-up spectroscopy with the ARC 3.5-m telescope confirmed this observation and yielded a derived abundance of A(Li)$_{NLTE}$ = 1.6 $\\pm$ 0.05. In addition, the high oxygen and low sodium abundances measured from the same spectrum suggest that vZ 1050 is a first generation cluster star. The location vZ 1050 above the horizontal branch and blueward of the red giant branch in the cluster's color-magnitude diagram places vZ 1050 on M3's asymptotic giant branch. The likely source for the enhanced lithium abundance is the Cameron-Fowler mechanism operating in vZ 1050 itself.

  6. The Abundance of Lithium in an ABG Star in the Globular Cluster M3 (NGC 5272)

    Science.gov (United States)

    Givens, R. A.; Pilachowski, C. A.

    2016-12-01

    A survey of red giants in the globular cluster M3 with the Hydra multi-object spectrograph on the WIYN 3.5 m telescope indicated a prominent Li i 6707 Å feature in the red giant vZ 1050. Followup spectroscopy with the ARC 3.5 m telescope confirmed this observation and yielded a derived abundance of A(Li)NLTE = 1.6 ± 0.05. In addition, the high oxygen and low sodium abundances measured from the same spectrum suggest that vZ 1050 is a first generation cluster star. The location of vZ 1050 above the horizontal branch and blueward of the red giant branch in the cluster’s color-magnitude diagram places vZ 1050 on M3's asymptotic giant branch. The likely source for the enhanced lithium abundance is the Cameron-Fowler mechanism operating in vZ 1050 itself.

  7. M3A system (2000–2005 – operation and maintenance

    Directory of Open Access Journals (Sweden)

    G. Petihakis

    2006-05-01

    Full Text Available During the Pilot Phase of the Mediterranean Forecasting System (MFSPP (1998–2001 a prototype observing system (Mediterranean Moored Multi-sensor Array – M3A was designed, developed and operated in the Cretan Sea for continuous oceanographic measurements in real time. The main problems encountered were associated with biofouling, underwater and aerial communication and with the design of the surface buoy. In the second phase of the MFS project named Mediterranean Forecasting System Towards Environmental Predictions (MFSTEP (2001–2005, the aim was to solve those problems and to consolidate the M3A. During the approximately five years of operation there were 13 scheduled and 15 emergency visits with a total duration of 65 days. The acquired experience through the maintenance program proved that the continuous observation of a so important system with a relative low cost is feasible.

  8. M3MS-16OR0401086 – Report on NEAMS Workbench Support for MOOSE Applications

    Energy Technology Data Exchange (ETDEWEB)

    Lefebvre, Robert A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Reactor and Nuclear Systems Division; Langley, Brandon R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Reactor and Nuclear Systems Division; Thompson, Adam B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Reactor and Nuclear Systems Division

    2016-09-23

    This report summarizes the status of the Nuclear Energy Advanced Modeling and Simulation (NEAMS) Workbench from Oak Ridge National Laboratory (ORNL) and the integration of the MOOSE framework. This report marks the completion of NEAMS milestone M3MS-16OR0401086. This report documents the developed infrastructure to support the MOOSE framework applications, the applications’ results, visualization status, the collaboration that facilitated this progress, and future considerations.

  9. New species of Triplocania Roesler with forewing M3 forked (Psocodea: 'Psocoptera': Ptiloneuridae), from Brazil.

    Science.gov (United States)

    Da Silva Neto, Alberto Moreira; Rafael, José Albertino; Aldrete, Alfonso N García

    2014-07-16

    Four new Brazilian species of Triplocania with forewing M3 forked are described and illustrated based on male specimens, namely: Triplocania lamasi n.sp. (Mato Grosso: Brazil), Triplocania mariateresae n.sp. (Rio de Janeiro: Brazil), Triplocania newi n.sp. (Tocantins: Brazil) and Triplocania plaumanni n.sp. (Santa Catarina: Brasil). They differ from all the other species in the genus, in which the males are known, by the hypandrium and phallosome structures.

  10. A novel antiarrhythmic target-M3-R/IKM3

    Institute of Scientific and Technical Information of China (English)

    Bao-fengYANG

    2004-01-01

    The total efficient rate of antiarrhythmic agents is only 30%to 60%, and the compounding problem is the lack of an effective therapy for some serious arrhythmias. Muscarinic receptors have been cloned and subdivided into the five subtypes M1, M2, M3,M4 and M5. And M2 receptors have long been believed to be the only functional subtype of muscarinic acetylcholine receptor (mAChR) in the heart, although recent studies have provided

  11. A picrotoxin-specific conformational change in the glycine receptor M2-M3 loop.

    Science.gov (United States)

    Hawthorne, Rebecca; Lynch, Joseph W

    2005-10-28

    The external loop linking the M2 and M3 transmembrane domains is crucial for coupling agonist binding to channel gating in the glycine receptor chloride channel (GlyR). A substituted cysteine accessibility scan previously showed that glycine activation increased the surface accessibility of 6 contiguous residues (Arg271-Lys276) toward the N-terminal end of the homomeric alpha1 GlyR M2-M3 loop. In the present study we used a similar approach to determine whether the allosteric antagonist, picrotoxin, could impose conformational changes to this domain that cannot be induced by varying agonist concentrations alone. Picrotoxin slowed the reaction rate of a sulfhydryl-containing compound (MTSET) with A272C, S273C, and L274C. Before interpreting this as a picrotoxin-specific conformational change, it was necessary to eliminate the possibility of steric competition between picrotoxin and MTSET. Accordingly, we showed that picrotoxin and the structurally unrelated blocker, bilobalide, were both trapped in the R271C GlyR in the closed state and that a point mutation to the pore-lining Thr6' residue abolished inhibition by both compounds. We also demonstrated that the picrotoxin dissociation rate was linearly related to the channel open probability. These observations constitute a strong case for picrotoxin binding in the pore. We thus conclude that the picrotoxin-specific effects on the M2-M3 loop are mediated allosterically. This suggests that the M2-M3 loop responds differently to the occupation of different binding sites.

  12. Development, Implementation and Evaluation of an M3 Community Health Curriculum

    Directory of Open Access Journals (Sweden)

    Staci Young, MS

    2004-03-01

    Full Text Available Objectives: This paper describes the development, implementation and evaluation of an M3 community health curriculum that responds to recent changes within the health care finance and delivery system. Methods: The new curriculum was developed based on AAMC recommendations, LCME requirements, a national review of undergraduate community health curricula, and an internal review of the integration of community health concepts in M3 clerkships. Results: The M3 curriculum teaches: 1 the importance of being a community responsive physician; 2 SES factors that influence health; 3 cultural competency; and 4 the role of physicians as health educators. Student evaluations for the first twelve months of implementation indicate that students are most satisfied with presentations and less satisfied with required readings and a patient interview project. Discussion: Most students agree that at the completion of the course they understand what it means to be a community-responsive physician, and they have developed skills to help them become more community responsive. Evaluation tools need to be developed to assess if students’ behavior has changed due to course participation.

  13. Performance of 500 m3 TankCell® at Kevitsa Cu-Ni-PGM concentrator

    Directory of Open Access Journals (Sweden)

    Mattsson Toni

    2016-01-01

    Full Text Available Outotec TankCell e500 flotation cell, with 500 m3 of efficient flotation volume, has been in operation since October 2014 at Kevitsa Cu-Ni-PGM concentrator as the first Cu rougher flotation cell. The 500 m3 flotation cell has proven to provide metallurgical superiority at very low specific power. On average the cell has recovered 71% of copper contained in the flotation feed. The cell has produced the concentrate with the Cu grade equal to 17% Cu. The typical specific power for the cell is around 0.4 kW/m3 (blower power not included. After the start-up of the cell the operating parameters have varied. The mixing speed have varied from 4.9 to 7.0 m/s and the superficial gas velocity from 0.3 to 1.5 cm/s. At various operating parameters the mixing, gas dispersion and metallurgical performance of the cell have been evaluated. In this paper a review of the hydrodynamic and metallurgical performance of the cell is presented. The paper focuses on the interactions of mixing intensity, bubble size and metallurgical performance in industrial application.

  14. Mice Lacking M1 and M3 Muscarinic Acetylcholine Receptors Have Impaired Odor Discrimination and Learning

    Science.gov (United States)

    Chan, Wilson; Singh, Sanmeet; Keshav, Taj; Dewan, Ramita; Eberly, Christian; Maurer, Robert; Nunez-Parra, Alexia; Araneda, Ricardo C.

    2017-01-01

    The cholinergic system has extensive projections to the olfactory bulb (OB) where it produces a state-dependent regulation of sensory gating. Previous work has shown a prominent role of muscarinic acetylcholine (ACh) receptors (mAChRs) in regulating the excitability of OB neurons, in particular the M1 receptor. Here, we examined the contribution of M1 and M3 mAChR subtypes to olfactory processing using mice with a genetic deletion of these receptors, the M1−/− and the M1/M3−/− knockout (KO) mice. Genetic ablation of the M1 and M3 mAChRs resulted in a significant deficit in odor discrimination of closely related molecules, including stereoisomers. However, the discrimination of dissimilar molecules, social odors (e.g., urine) and novel object recognition was not affected. In addition the KO mice showed impaired learning in an associative odor-learning task, learning to discriminate odors at a slower rate, indicating that both short and long-term memory is disrupted by mAChR dysfunction. Interestingly, the KO mice exhibited decreased olfactory neurogenesis at younger ages, a deficit that was not maintained in older animals. In older animals, the olfactory deficit could be restored by increasing the number of new born neurons integrated into the OB after exposing them to an olfactory enriched environment, suggesting that muscarinic modulation and adult neurogenesis could be two different mechanism used by the olfactory system to improve olfactory processing. PMID:28210219

  15. Goldschmidt crater and the Moon's north polar region: Results from the Moon Mineralogy Mapper (M3)

    Science.gov (United States)

    Cheek, L.C.; Pieters, C.M.; Boardman, J.W.; Clark, R.N.; Combe, J.-P.; Head, J.W.; Isaacson, P.J.; McCord, T.B.; Moriarty, D.; Nettles, J.W.; Petro, N.E.; Sunshine, J.M.; Taylor, L.A.

    2011-01-01

    Soils within the impact crater Goldschmidt have been identified as spectrally distinct from the local highland material. High spatial and spectral resolution data from the Moon Mineralogy Mapper (M3) on the Chandrayaan-1 orbiter are used to examine the character of Goldschmidt crater in detail. Spectral parameters applied to a north polar mosaic of M3 data are used to discern large-scale compositional trends at the northern high latitudes, and spectra from three widely separated regions are compared to spectra from Goldschmidt. The results highlight the compositional diversity of the lunar nearside, in particular, where feldspathic soils with a low-Ca pyroxene component are pervasive, but exclusively feldspathic regions and small areas of basaltic composition are also observed. Additionally, we find that the relative strengths of the diagnostic OH/H2O absorption feature near 3000 nm are correlated with the mineralogy of the host material. On both global and local scales, the strongest hydrous absorptions occur on the more feldspathic surfaces. Thus, M3 data suggest that while the feldspathic soils within Goldschmidt crater are enhanced in OH/H2O compared to the relatively mafic nearside polar highlands, their hydration signatures are similar to those observed in the feldspathic highlands on the farside. Copyright 2011 by the American Geophysical Union.

  16. The WA105-3x1x1 m3 dual phase LAr-TPC demonstrator

    CERN Document Server

    Murphy, Sebastien

    2016-11-15

    The dual phase Liquid Argon Time Projection Chamber (LAr TPC) is the state-of-art technology for neutrino detection thanks to its superb 3D tracking and calorimetry performance. Its main feature is the charge amplification in gas argon which provides excellent signal-to-noise ratio. Electrons produced in the liquid argon are extracted in the gas phase. Here, a readout plane based on Large Electron Multiplier detectors provides amplification of the charges before its collection onto an anode with strip readout. The charge amplification enables constructing fully homoge- nous giant LAr-TPCs with tuneable gain, excellent charge imaging performance and increased sensitivity to low energy events. Following a staged approach the WA105 collaboration is con- structing a dual phase LAr-TPC with an active volume of 3x1x1m3 that will soon be tested with cosmic rays. Its construction and operation aims to test scalable solutions for the crucial aspects of this technology: ultra high argon purity in non-evacuable tank, la...

  17. If Information Wants To Be Free...Then Who's Going To Pay for It? [and] A Question of Access: SPARC, BioOne, and Society-Driven Electronic Publishing [and] Who Is Going To Mine Digital Library Resources? And How?

    Science.gov (United States)

    Kaser, Richard T.; Johnson, Richard K.; Rudner, Lawrence

    2000-01-01

    Discusses Fair Use and the public perception; models for funding information services; publishers illusion that information is/should be free; Internet's role in making information freely available; scholarly communication systems: Scholarly Publishing and Academic Resources Coalition (SPARC) and BioOne (an electronic aggregation of bioscience…

  18. If Information Wants To Be Free...Then Who's Going To Pay for It? [and] A Question of Access: SPARC, BioOne, and Society-Driven Electronic Publishing [and] Who Is Going To Mine Digital Library Resources? And How?

    Science.gov (United States)

    Kaser, Richard T.; Johnson, Richard K.; Rudner, Lawrence

    2000-01-01

    Discusses Fair Use and the public perception; models for funding information services; publishers illusion that information is/should be free; Internet's role in making information freely available; scholarly communication systems: Scholarly Publishing and Academic Resources Coalition (SPARC) and BioOne (an electronic aggregation of bioscience…

  19. Impact of two interventions on timeliness and data quality of an electronic disease surveillance system in a resource limited setting (Peru: a prospective evaluation

    Directory of Open Access Journals (Sweden)

    Quispe Jose A

    2009-03-01

    Full Text Available Abstract Background A timely detection of outbreaks through surveillance is needed in order to prevent future pandemics. However, current surveillance systems may not be prepared to accomplish this goal, especially in resource limited settings. As data quality and timeliness are attributes that improve outbreak detection capacity, we assessed the effect of two interventions on such attributes in Alerta, an electronic disease surveillance system in the Peruvian Navy. Methods 40 Alerta reporting units (18 clinics and 22 ships were included in a 12-week prospective evaluation project. After a short refresher course on the notification process, units were randomly assigned to either a phone, visit or control group. Phone group sites were called three hours before the biweekly reporting deadline if they had not sent their report. Visit group sites received supervision visits on weeks 4 & 8, but no phone calls. The control group sites were not contacted by phone or visited. Timeliness and data quality were assessed by calculating the percentage of reports sent on time and percentage of errors per total number of reports, respectively. Results Timeliness improved in the phone group from 64.6% to 84% in clinics (+19.4 [95% CI, +10.3 to +28.6]; p Conclusion Regular phone reminders significantly improved timeliness of reports in clinics and ships, whereas supervision visits led to improved data quality only among clinics. Further investigations are needed to establish the cost-effectiveness and optimal use of each of these strategies.

  20. Metadata for Electronic Information Resources

    Science.gov (United States)

    2004-12-01

    among digital libraries . METS provides an XML DTD that can point to metadata in other schemes by declaring the scheme that is being used. For example...site: www.niso.org/news/Metadata_simpler.pdf International Federation of Library Associations and Institutions (IFLA). (2002). Digital Libraries : Metadata

  1. 基于ASP.NET的电子资源整合系统设计与实现%Design and Realization of an Integrated Electronic Resource System Based on ASP.NET

    Institute of Scientific and Technical Information of China (English)

    冀宪武; 陈晓冬; 何燕; 杨方; 曹宇宾; 潘大丰

    2011-01-01

    电子信息资源的整合是数字图书馆建设中的一个非常重要的环节,论述了数字资源整合的必要性,结合农业图书馆的实际,开展了电子资源整合服务平台的设计与实现。%The integration of electronic information resources is a very important part in digital library construction.In this paper,the necessity for integration of digital resources was discussed,combined with the actuality of the agricultural library,the design and implementation about services platform of electronic resource integration were carried out.

  2. The Moon Mineralogy (M3) Imaging Spectrometer: Early Assessment of the Spectral, Radiometric, Spatial and Uniformity Properties

    Science.gov (United States)

    Green, Robert O.; Pieters, C. M.; Boardman, J.; Barr, D.; Bruce, C.; Bousman, J.; Chatterjee, A.; Eastwood, M.; Essandoh, V.; Geier, S.; Glavich, T.; Green, R.; Haemmerle, V.; Hyman, S.; Hovland, L.; Koch, T.; Lee, K.; Lundeen, S.; Motts, E.; Mouroulis, P.; Paulson, S.; Plourde, K.; Racho, C.; Robinson, D.; Rodriquez, J.

    2009-01-01

    The Moon Mineralogy Mapper's (M3) is a high uniformity and high signal-to-noise ratio NASA imaging spectrometer that is a guest instrument on the Indian Chandrayaan-1 Mission to the Moon. The laboratory measured spectral, radiometric, spatial, and uniformity characteristics of the M3 instrument are given. The M3 imaging spectrometer takes advantage of a suite of critical enabling capabilities to achieve its measurement requirement with a mass of 8 kg, power usage of 15 W, and volume of 25X18X12 cm. The M3 detector and spectrometer are cooled by a multi-stage passive cooler. This paper presents early M3 performance assessment results.

  3. Comparison of the space radiation environment at Foton M3 satellite altitudes and on aircraft altitudes for minimum of solar activity

    Science.gov (United States)

    Ploc, Ondrej; Dachev, Tsvetan; Spurny, Frantisek; Tomov, Borislav; Dimitrov, Plamen; Matviichuk, Yury; Bankov, Nikolay

    The space radiation environments at Foton M3 and aircraft altitudes were measured by using of practically equal silicon detector based on a deposited energy spectrometers in the fall of 2007. The aircraft measurements were performed on commercial flights of CSA airlines, while the Foton M3 measurements were inside of the ESA Biopan 6 experiment. Foton M3 orbit was close to circular between 260 and 289 km altitude and about 63° inclination. The relatively high inclination and small shielding of the detector (0.81 g/cm2 ) allow us to observe doses by electrons in the outer radiation belt as high as 2.3 mGy/hour. The comparison of the total GCR deposited doses for the Foton M3 time interval, which coincides with the absolute cycle 23 minimum of the solar activity is about 15% higher than the measured during the Foton M2 satellite doses in 2005. Comparisons of the latitudinal profiles for ISS in 2001, Foton 2 and 3 satellites and aircrafts show that the ratio of doses is as 1:2:3. Aircraft measurements are characterised through average values of exposure during frequent, statistically well based measurements on the routes Prague - New York. Dose absorbed in Si-detector per flight on these routes was about 8% higher in 2007 than in 2005. Different comparisons with the existing models for the radiation environment on aircraft and spacecraft altitudes are presented in the paper also and discussed.

  4. Library resources on the Internet

    Science.gov (United States)

    Buchanan, Nancy L.

    1995-07-01

    Library resources are prevalent on the Internet. Library catalogs, electronic books, electronic periodicals, periodical indexes, reference sources, and U.S. Government documents are available by telnet, Gopher, World Wide Web, and FTP. Comparatively few copyrighted library resources are available freely on the Internet. Internet implementations of library resources can add useful features, such as full-text searching. There are discussion lists, Gophers, and World Wide Web pages to help users keep up with new resources and changes to existing ones. The future will bring more library resources, more types of library resources, and more integrated implementations of such resources to the Internet.

  5. Vasco da Gama 33000m3耙吸挖泥船

    Institute of Scientific and Technical Information of China (English)

    刘厚恕; 顾洁

    2001-01-01

    The 33000m3 Vasco da Gama was delivered to the owner in 2000, which is the largest trailing suction hopper dredger up to now. The vessel is designed for the following main functions: loading spoil with two side suction pipes at a depth of 45-60m; transporting the spoil at a speed of 16.Skn; dumping spoil through six pairs of bottom doors; self-discharging of spoil via floating pipeline; self-discharging of spoil through bow-jet nozzle; deep dredging at 131m with 5500kW submerged dredge pump. This paper fully described its arrangement, key dredging equipments and major design features,

  6. Deposition of CdTe films under microgravity: Foton M3 mission

    Energy Technology Data Exchange (ETDEWEB)

    Benz, K.W.; Croell, A. [Freiburger Materialforschungszentrum FMF, Albert-Ludwigs-Universitaet Freiburg (Germany); Zappettini, A.; Calestani, D. [CNR Parma, Instituto Materiali Speciali per Elettronica e Magnetismo IMEM, Fontani Parma (Italy); Dieguez, E. [Universidad Autonoma de Madrid (Spain). Departamento de Fisica de Materiales; Carotenuto, L.; Bassano, E. [Telespazio Napoli, Via Gianturco 31, 80146 Napoli (Italy); Fiederle, M.

    2009-10-15

    Experiments of deposition of CdTe films have been carried out under microgravity in the Russian Foton M3 mission. The influence of gravity has been studied with these experiments and compared to the results of simulations. The measured deposition rate could be confirmed by the theoretical results for lower temperatures. For higher temperatures the measured thickness of the deposited films was larger compared to the theoretical data. (copyright 2009 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  7. Postpartum Diagnosis of AML-M3: A Rare Case Report

    Directory of Open Access Journals (Sweden)

    Manjula Biradar

    2016-07-01

    Full Text Available A 27 year old female gravid 2, para 1, presented at 39 weeks of gestation with pain in abdomen going in for labour, and delivered healthy baby. The patient later had post-partum haemorrhage with Prothrombin Time (PT 10min, platelet count 70,000 cells/cumm. Peripheral smear showed shift to left with myeloblasts, promyelocytes. The diagnosis of Acute Myeloid Leukemia (AML was given and advised for bone marrow examination. The diagnosis AML-M3 was confirmed by marrow study. Unfortunately, patient went in for Disseminated Intravascular Coagulation (DIC and died 2 days after the diagnosis.

  8. Lunar Exploration Insights Recognized from Chandrayaan-1 M3 Imaging Spectrometer

    Science.gov (United States)

    Pieters, Carle; Green, Robert O.; Boardman, Joseph

    2016-07-01

    One of the most important lessons learned from the renaissance of lunar exploration over the last decade is that new discoveries and surprises occur with every new mission to the Moon. Although the color of the Moon had been measured using Earth-based telescopes even before Apollo, modern instruments sent to orbit the Moon provide a scope of inquiry unimaginable during the last century. Spacecraft have now been successfully sent to the Moon by six different space agencies from around the world and the number is growing. The Indian Chandrayaan- 1 spacecraft carried a suite of indigenous instruments as well as several guest instruments from other countries, including the Moon Mineralogy Mapper (M-cube) supplied by NASA. Even though Chandrayaan's lifetime in orbit was shortened by technical constraints, M3 provided a taste of the power of near-infrared imaging spectroscopy used for science and exploration at the Moon. Contrary to expectations, the lunar surface was discovered to be hydrated, which is now known to result from solar wind H combining with O of rocks and soil. Surficial hydration was found to be pervasive across the Moon and the limited data hint at both local concentrations and temporal variations. The prime objective of M3 was to characterize lunar mineralogy in a spatial context. Working in tandem with related instruments on JAXA's SELENE, M3 readily recognized and mapped known minerals from mare and highland terrains (pyroxenes, olivine) at high resolution, but also detected diagnostic properties of crystalline plagioclase which, when mapped across a spatial context, enabled the unambiguous identification of a massive crustal layer of plagioclase that clearly resulted from an early magma ocean. An additional surprise came with the discovery of a new rock type on the Moon that had not been recognized in samples returned by Apollo and Luna: a Mg-rich spinel anorthosite associated with material excavated from some of the greatest lunar depths. In

  9. Forsmark Site: M3 modelling and 2D visualisation of the hydrochemical parameters in Forsmark groundwater

    Energy Technology Data Exchange (ETDEWEB)

    Gurban, Ioana (3D Terra (Canada))

    2008-08-15

    This work represents the stage 2.3 of the hydrochemical evaluation and modelling of the Forsmark data. This comprises M3 modelling and 2D visualisation of the data along the boreholes. The following conclusions can be drawn: - M3 modelling helped to summarise and understand the data, by using as variables the major elements and the isotopes delta18O and deltaD. - Previous alternative models and the experience from Forsmark 1.2, 2.1 and 2.2, helped to clarify different previously unsolved issues such as: the use of variables, tests with different endmembers, the use of only groundwater data in order to build a bedrock hydrochemical model. - The visualisation of the mixing proportions along the boreholes helps to understand the distribution of the data in the domain and to check and compare the results of different models; and therefore to chose the model which best describes the measured data. - The different M3 modelling tests resulted in the following conclusions: a) When calculating mixing proportions only samples from the boreholes will be used, b) the altered meteoric end-member which best describes the more shallow groundwater compositions is defined by a representative upper bedrock sample; the Littorina end-member employed the existing modelled compositions; the Deep saline and glacial end-members compositions were tested by means of a feasibility study and employed in the modelling. - Three models were presented. All the models are good and can be used, but the best is to use the one that fits the conceptual model best and the hydrogeochemical understanding. - The use of Littorina, Glacial, Deep Saline and Altered Meteoric end-members makes possible the comparison of different sites such as Laxemar and Forsmark. - All the data used in the M3 modelling and the results of the modelling and visualisation along the boreholes are presented in SKB database SIMON. - The extended data do not affect the results of the modelling of the Forsmark 2.3 dataset (the

  10. The Mediterranean Moored Multi-sensor Array (M3A: system development and initial results

    Directory of Open Access Journals (Sweden)

    K. Nittis

    Full Text Available Operational forecasting of ocean circulation and marine ecosystem fluctuations requires multi-parametric real-time measurements of physical and biochemical properties. The architecture of a system that is able to provide such measurements from the upper-thermocline layers of the Mediterranean Sea is described here. The system was developed for the needs of the Mediterranean Forecasting System and incorporates state-of-the-art sensors for optical and chemical measurements in the upper 100 m and physical measurements down to 500 m. Independent moorings that communicate via hydro-acoustic modems are hosting the sensors. The satellite data transfer and the large autonomy allow for the operation of the system in any open-ocean site. The system has been in pre-operational use in the Cretan Sea since January 2000. The results of this pilot phase indicate that multi-parametric real-time observations with the M3A system are feasible, if a consistent maintenance and re-calibration program is followed. The main limitations of the present configuration of M3A are related: (a to bio-fouling that primarily affects the turbidity and secondarily affects the other optical sensors, and (b to the limited throughput of the currently used satellite communication system.

    Key words. Atmospheric composition and structure (instruments and techniques. Oceanography: general (ocean prediction Oceanography: physical (upper ocean process

  11. Connexins and M3 Muscarinic Receptors Contribute to Heterogeneous Ca2+ Signaling in Mouse Aortic Endothelium

    Directory of Open Access Journals (Sweden)

    François-Xavier Boittin

    2013-02-01

    Full Text Available Background/Aims: Smooth muscle tone is controlled by Ca2+ signaling in the endothelial layer. Mouse endothelial cells are interconnected by gap junctions made of Connexin40 (Cx40 and Cx37, which allow the exchange of signaling molecules to coordinate their activity. Here, we investigated the role of Cx40 in the endothelial Ca2+ signaling of the mouse aorta. Methods: Ca2+ imaging was performed on intact aortic endothelium from both wild type (Cx40+/+ and Connexin40-deficient (Cx40 -/- mice. Results: Acetylcholine (ACh induced early fast and high amplitude Ca2+ transients in a fraction of endothelial cells expressing the M3 muscarinic receptors. Inhibition of intercellular communication using carbenoxolone or octanol fully blocked the propagation of ACh-induced Ca2+ transients toward adjacent cells in WT and Cx40-/- mice. As compared to WT, Cx40-/- mice displayed a reduced propagation of ACh-induced Ca2+ waves, indicating that Cx40 contributes to the spreading of Ca2+ signals. The propagation of those Ca2+ responses was not blocked by suramin, a blocker of purinergic ATP receptors, indicating that there is no paracrine effect of ATP release on the Ca2+ waves. Conclusions: Altogether our data show that Cx40 and Cx37 contribute to the propagation and amplification of the Ca2+ signaling triggered by ACh in endothelial cells expressing the M3 muscarinic receptors.

  12. HST Observations of Blue Straggler Stars in the Core of the Globular Cluster M3

    CERN Document Server

    Ferraro, F R; Pecci, F F; Cacciari, C; Dorman, B; Rood, R T; Buonanno, R; Corsi, C E; Burgarella, D; Laget, M

    1997-01-01

    The core of the Galactic Globular Cluster M3 (NGC 5272) has been observed with the WFPC2 through the filters F255W, F336W, F555W, and F814W. Using these observations along with a thorough reanalysis of earlier catalogs, we have produced a catalog of blue straggler stars (BSS) spanning the cluster. Earlier studies and the fainter part of our sample suffer severe selection biases. Our analysis is based on a more reliable bright global sample of 122 BSS. We confirm earlier suggestions that the radial BSS distribution in M3 is bimodal. It is strongly peaked in the center, has a clear dip 100--200" from the center, and rises again at larger radii. The observed distribution agrees with the dynamical model of Sigurdsson et al. (1994) which takes into account both star collisions and merging of primordial binaries for the origin of BSS. The observed luminosity functions of BSS in the inner and outer parts of the cluster are different. Interpreting these using the models of Bailyn & Pinsonneault (1995), we suggest...

  13. Scale-up of industrial biodiesel production to 40 m3using a liquid lipase formulation

    DEFF Research Database (Denmark)

    Price, Jason; Nordblad, Mathias; Martel, Hannah H.

    2016-01-01

    In this work, we demonstrate the scale-up from an 80 L fed-batch scale to 40 m3 along with the design of a 4 m3continuous process for enzymatic biodiesel production catalysed by NS-40116 (a liquid formulation of a modified Thermomyces lanuginosus lipase). Based on the analysis of actual pilot plant...... the fed-batch and CSTR cases. Given similar operating conditions, the CSTR operation on average, has a reaction time which is 1.3 times greater than the fed-batch operation. We also showed how the process metrics can be used to quickly estimate the selling price of the enzyme. Assuming a biodiesel selling...... price of 0.6 USD/kg and a one-time use of the enzyme (0.1% (w/woil) enzyme dosage); the enzyme can then be sold for 30 USD/kg which ensures that that the enzyme cost is not more than 5% of the biodiesel revenue. This article is protected by copyright. All rights reserved...

  14. M3A system (2000–2005 – operation and maintenance

    Directory of Open Access Journals (Sweden)

    G. Petihakis

    2007-01-01

    Full Text Available During the pilot phase of the Mediterranean Forecasting System (MFSPP (2000 2003, a prototype observing system (Mediterranean Moored Multi-sensor Array – M3A was designed, developed and operated in the Cretan Sea for continuous oceanographic measurements in real time. The main problems encountered were associated with biofouling, underwater and aerial communication and with the design of the surface buoy. In the second phase of the MFS project named Mediterranean Forecasting System Towards Environmental Predictions (MFSTEP (2003–2005, the aim was to solve those problems and to consolidate the M3A. For the minimisation of biofouling a pilot field study was performed and the techniques of bromine solution and copper shielding were evaluated. Additionally, the oligotrophy of the Aegean Sea dictated the need to ignore factory calibrations and to perform site-specific laboratory calibrations of the sensors. This procedure was proved necessary and produced calibration coefficients that gave results comparable to the measurements obtained with the laboratory analysis method. During the approximately five years of operation, there were 13 scheduled and 15 emergency visits, with a total duration of 65 days. The acquired experience through the maintenance program proved that the continuous observation of such a very important system with a relative low cost is feasible.

  15. Machining risk of beryllium disease and sensitization with median exposures below 2 micrograms/m3.

    Science.gov (United States)

    Kreiss, K; Mroz, M M; Newman, L S; Martyny, J; Zhen, B

    1996-07-01

    We examined the prevalence of beryllium sensitization in relation to work process and beryllium exposure measurements in a beryllia ceramics plant that had operated since 1980. We interviewed 136 employees (97.8% of the workforce), ascertained beryllium sensitization with the beryllium lymphocyte proliferation blood test, and reviewed historical industrial hygiene measurements. Of eight beryllium-sensitized employees (5.9%), six (4.4% of participating employees) had granulomatous disease on transbronchial lung biopsy. Machinists had a sensitization rate of 14.3% compared to a rate of 1.2% among other employees. Machining had significantly higher general area and breathing zone measurements than did other processes in the time period in which most beryllium-sensitized cases had started machining work. Daily weighted average (DWA) estimates of exposure for matching processes also exceeded estimates for other work processes in that time period, with a median DWA of 0.9 microgram/m3. Machining process DWAs accounted for the majority of DWAs exceeding the 2.0 micrograms/m3 OSHA standard, with 8.1% of machining DWAs above the standard. We conclude that lowering machining process-related exposures may be important to lowering risk of beryllium disease.

  16. 基于 EZproxy 日志的电子资源异常访问行为研究%Research on Abnormal Access to Electronic Resources Based on EZproxy Logs

    Institute of Scientific and Technical Information of China (English)

    雷东升; 郭振英

    2016-01-01

    The off - campus access to electronic resources in the library benefits readers a lot .Meanwhile ,some abnormal access behavior arises .The paper analyzed the electronic resources access log with EZproxyog proxy server ,designed and devel-oped the EZproxy log analysis system so as to pretreat ,upload ,count and analyze the access log to electronic resources .To dis-cover the abnormal access behavior of readers on the basis of the characteristics of their access and to classify the abnormal behav -ior , the paper could avoid that IP is temporarily blocked by the supporters of database of electronic resources in the library so that can maintain the readers' rights and improve the efficiency of resource access .%校外访问图书馆电子资源在方便读者的同时也出现一些异常访问行为,利用 EZproxy 代理服务器日志信息分析异常访问行为特征,设计并开发 EZproxy 日志分析系统,完成对电子资源访问日志的预处理、上传、统计和分析,从访问特征发掘读者的异常访问行为,对异常行为情况分类处理,基本避免了异常访问行为导致图书馆电子资源被数据库商临时封掉 IP 的现象出现,维护图书馆读者的合法权利,提高资源访问效率。

  17. VARIABILITY STUDIES IN M3 GENERATION IN BLACKGRAM (VIGNA MUNGO (L.HEPPER

    Directory of Open Access Journals (Sweden)

    M P MESHRAM

    2013-12-01

    Full Text Available In the present study, pure line seeds of black gram variety viz. T-9, TPU-4 and one promising genotype AKU-18 was treated with gamma irradiation (15kR, 25kR and 35kR with the objective to assess the variability in M3 generation.. Highest GCV and PCV and high estimates of heritability were recorded for the characters sprouting percentage, number of pods plant-1 and grain yield plant-1 (g. High heritability accompanied with high genetic advance was recorded for number of pods plant-1 governed by additive gene effects and therefore selection based on phenotypic performance will be useful to improve character in future.

  18. Trimble M3 1” and South Nts-362R Total Station Angle Measurement Accuracy Analysis

    Directory of Open Access Journals (Sweden)

    Oleniacz Grzegorz

    2017-03-01

    Full Text Available The main purpose of this study was to obtain information about the actual precision of angle measurements with two instruments (Trimble M3 1 "and South NTS-362R, realizable in given measurement conditions. This object is achieved by using a simplified method of testing instruments contained in the PN-ISO 17123-3 standard [1]. This is a continuation of research described in [2], carried out on the same test base, but this time in a different, less favorable field conditions. The use of the same instrument has created an opportunity to compare and analyze the measurement results. The scope of work includes the measurement and results preparation along with statistical processing of the obtained results for both instruments.

  19. Half lives of spherical proton emitters using density dependent M3Y interaction

    CERN Document Server

    Chowdhury, P R; Basu, D N

    2005-01-01

    The proton radioactivity lifetimes of spherical proton emitters from the ground and the isomeric states are calculated using the microscopic nucleon-nucleus interaction potentials. The daughter nuclei density distributions are folded with a realistic density dependent M3Y effective interaction supplemented by a zero-range pseudo-potential. The density dependence parameters of the interaction are extracted from the nuclear matter calculations. The saturation energy per nucleon used for nuclear matter calculations is determined from the co-efficient of the volume term of Bethe-Weizsacker mass formula which is evaluated by fitting the recent experimental and estimated atomic mass excesses from Audi-Wapstra-Thibault atomic mass table by minimizing the mean square deviation. The quantum mechanical tunneling probability is calculated within the WKB approximation. Spherical charge distributions are used for calculating the Coulomb interaction potentials. These calculations provide good estimates for the observed pro...

  20. Electrodialytic remediation of CCA-treated waste wood in a 2 m3 pilot plant

    DEFF Research Database (Denmark)

    Christensen, Iben Vernegren; Pedersen, Anne Juul; Ottosen, Lisbeth M.;

    2006-01-01

    Waste wood that has been treated with chromated-copper-arsenate (CCA) poses a potential environmental problem due to the content of copper, chromium and arsenic. A pilot plant for electrodialytic remediation of up to 2 m3 wood has been designed and tested and the results are presented here. Several...... fractions. The best remediation efficiency was obtained in an experiment with an electrode distance of 60 cm, and 100 kg wood chips. In this experiment 87% copper, 81% chromium and > 95% arsenic were removed. One other experiment was also analysed for arsenic. In this experiment the distance between...... the working electrodes was 1.5 m and here 95% As was removed. The results showed that arsenic may be the easiest removable of the copper, chromium and arsenic investigated here. This is very encouraging since arsenic is the CCA components of most environmental concern....

  1. Variable Star Status of Two Stars: V204 and I-I-39 in M3

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The star I-I-42 (=vZ1390), a cluster member in M3, located near the red edge of the instability strip of the horizontal branch, was discovered by Roberts and Sandage as a low amplitude variable, it was designated as V204 in the "second catalogue of variable stars in globular clusters", but its coordinates given in all versions of this catalogue are wrong since 1955. We argue that V204 is indeed a low amplitude HB variable star, located near to the red edge of the instability strip, with a period of 0.74785d and an amplitude of about 0.04 mag in V. We also find that the red cluster member star I-I-39 is a low amplitude variable with a period of 1.16d and amplitude of about 0.03 mag in V which might be pulsating at the second overtone.

  2. Modeling of lithium granule injection in NSTX using M3D-C1

    Science.gov (United States)

    Fil, A.; Kolemen, E.; Ferraro, N.; Jardin, S.; Parks, P. B.; Lunsford, R.; Maingi, R.

    2017-05-01

    In this paper, we present simulations of pedestal control by lithium granule injection (LGI) in NSTX. A model for small granule ablation has been implemented in the M3D-C1 code (Jardin et al 2012 Comput. Sci. Discovery 5 014002), allowing the simulation of realistic lithium granule injections. 2D and 3D simulations of Li injections in NSTX H-mode plasmas are performed and the effect of granule size, injection angle and velocity on the pedestal gradient increase is studied. The amplitude of the local pressure perturbation caused by the granules is found to be highly dependent on the solid granule size. Adjusting the granule injection velocity allows one to inject more particles at the pedestal top. 3D simulations show the destabilization of high order MHD modes whose amplitude is directly linked to the localized pressure perturbation, which is found to depend on the toroidal localization of the granule density source.

  3. CH5M3D: an HTML5 program for creating 3D molecular structures.

    Science.gov (United States)

    Earley, Clarke W

    2013-11-18

    While a number of programs and web-based applications are available for the interactive display of 3-dimensional molecular structures, few of these provide the ability to edit these structures. For this reason, we have developed a library written in JavaScript to allow for the simple creation of web-based applications that should run on any browser capable of rendering HTML5 web pages. While our primary interest in developing this application was for educational use, it may also prove useful to researchers who want a light-weight application for viewing and editing small molecular structures. Molecular compounds are drawn on the HTML5 Canvas element, with the JavaScript code making use of standard techniques to allow display of three-dimensional structures on a two-dimensional canvas. Information about the structure (bond lengths, bond angles, and dihedral angles) can be obtained using a mouse or other pointing device. Both atoms and bonds can be added or deleted, and rotation about bonds is allowed. Routines are provided to read structures either from the web server or from the user's computer, and creation of galleries of structures can be accomplished with only a few lines of code. Documentation and examples are provided to demonstrate how users can access all of the molecular information for creation of web pages with more advanced features. A light-weight (≈ 75 kb) JavaScript library has been made available that allows for the simple creation of web pages containing interactive 3-dimensional molecular structures. Although this library is designed to create web pages, a web server is not required. Installation on a web server is straightforward and does not require any server-side modules or special permissions. The ch5m3d.js library has been released under the GNU GPL version 3 open-source license and is available from http://sourceforge.net/projects/ch5m3d/.

  4. Analysis on the Thinking Modes of Medical Users Utilizing Library Electronic Resources%医药学用户使用图书馆电子资源的思维模式分析

    Institute of Scientific and Technical Information of China (English)

    陈东滨; 应峻; 辛继宾; 徐一新

    2012-01-01

    The paper studies the thinking modes of medical users utilizing electronic resources in college and university libraries. Combining with the questionnaires,in - depth analysis of utilization desire,utilization decision,impact factors of utilization behaviors are compiled,in order to provide references for college and university libraries formulating electronic resources marketing strategies.%研究高校图书馆医药学用户在使用电子资源过程中的思维模式,结合问卷调查结果深入分析思维模式中使用意愿、使用决策、使用行为的影响因素,为高校图书馆制定电子资源营销策略提供依据。

  5. Review of Researches on the Usage Standard Management of Electronic Resources in China from 2000 to 2010%2000—20l0年我国电子资源使用的规范管理研微

    Institute of Scientific and Technical Information of China (English)

    宛玲; 杜坤

    2012-01-01

    In recent years, electronic resources play an increasingly important role in research, teaching and other works. Through the statistical analysis of the domestic research on the usage standard management of electronic resources from 2000 to 2010, we find that the issue of the usage standard management of electronic resources is increasingly concerned by the public and researchers. But there are still some problems, such as lack of systematic discussion and empirical research, scattered research topics, most research results on guidance proposals, and so on. Our researches about usage standard management of electronic resources should strengthen researches on the user, related technologies, licensing alliance, strengthen the communication between libraries and database providers, and strengthen the analysis and absorption of foreign experience.%目前,电子资源在科研、教学等工作中扮演着越来越重要的角色。通过对2000-2010年我国电子资源使用规范管理研究文献的统计分析发现,虽然公众及科研人员对电子资源使用的规范的关注程度越来越高,但是仍存在缺乏系统性的论述和实证性的研究、研究主题过于分散、研究成果多为指导性建议等问题。我国电子资源使用规范管理研究应加强对用户、相关技术、许可联盟的研究,加强对图书馆与数据库商交流的研究,加强对国外经验的分析与吸收。

  6. 高校图书馆电子资源购买过程中的委托-代理关系探究%Principal-agent Relationship During the Electronic Resources Purchase Process of University Libraries

    Institute of Scientific and Technical Information of China (English)

    桂君; 吴冬曼

    2012-01-01

    The prineipal-agent relationship is throughout the whole process of the electronic resources purchase for university libraries. Based on the asymmetric informatiun theory the issues of information asymmetries in the purchase process of electronic resources for university libraries are analyzed. The major prineipal-agent relationships between the university libraries, the group organizers and the database providers ate studied. The operational characteristics and existing problems in the purchase process of electronic resources for university libraries are also discussed. Taking this opportunity to attention the principal-agent relationships existed in the electronic resources purchase of university libraries, the authors hope to solve some problems caused by the market information asymmetry.%委托-代理关系贯穿了高校图书馆电子资源的购买全过程,,基于信息不对称理论,分析高校图书馆电子资源购买中的信息不对称现象,并以高校图书馆、集团组织者、数据库提供者为主体,研究高校图书馆电子资源采购过程中存在的几种主要委托-代理关系、业务特点和存在的问题、通过对委托-代理关系的研究和分析,合理把握电子资源采购的规律,可以部分解决高校电子资源购买中由市场信息不平衡所带来的问题。

  7. M3 Macrophages Stop Division of Tumor Cells In Vitro and Extend Survival of Mice with Ehrlich Ascites Carcinoma.

    Science.gov (United States)

    Kalish, Sergey; Lyamina, Svetlana; Manukhina, Eugenia; Malyshev, Yuri; Raetskaya, Anastasiya; Malyshev, Igor

    2017-01-26

    BACKGROUND M1 macrophages target tumor cells. However, many tumors produce anti-inflammatory cytokines, which reprogram the anti-tumor M1 macrophages into the pro-tumor M2 macrophages. We have hypothesized that the problem of pro-tumor macrophage reprogramming could be solved by using a special M3 switch phenotype. The M3 macrophages, in contrast to the M1 macrophages, should respond to anti-inflammatory cytokines by increasing production of pro-inflammatory cytokines to retain its anti-tumor properties. Objectives of the study were to form an M3 switch phenotype in vitro and to evaluate the effect of M3 macrophages on growth of Ehrlich ascites carcinoma (EAC) in vitro and in vivo. MATERIAL AND METHODS Tumor growth was initiated by an intraperitoneal injection of EAC cells into C57BL/6J mice. RESULTS 1) The M3 switch phenotype can be programed by activation of M1-reprogramming pathways with simultaneous inhibition of the M2 phenotype transcription factors, STAT3, STAT6, and/or SMAD3. 2) M3 macrophages exerted an anti-tumor effect both in vitro and in vivo, which was superior to anti-tumor effects of cisplatin or M1 macrophages. 3) The anti-tumor effect of M3 macrophages was due to their anti-proliferative effect. CONCLUSIONS Development of new biotechnologies for restriction of tumor growth using in vitro reprogrammed M3 macrophages is very promising.

  8. M3 Macrophages Stop Division of Tumor Cells In Vitro and Extend Survival of Mice with Ehrlich Ascites Carcinoma

    Science.gov (United States)

    Kalish, Sergey; Lyamina, Svetlana; Manukhina, Eugenia; Malyshev, Yuri; Raetskaya, Anastasiya; Malyshev, Igor

    2017-01-01

    Background M1 macrophages target tumor cells. However, many tumors produce anti-inflammatory cytokines, which reprogram the anti-tumor M1 macrophages into the pro-tumor M2 macrophages. We have hypothesized that the problem of pro-tumor macrophage reprogramming could be solved by using a special M3 switch phenotype. The M3 macrophages, in contrast to the M1 macrophages, should respond to anti-inflammatory cytokines by increasing production of pro-inflammatory cytokines to retain its anti-tumor properties. Objectives of the study were to form an M3 switch phenotype in vitro and to evaluate the effect of M3 macrophages on growth of Ehrlich ascites carcinoma (EAC) in vitro and in vivo. Material/Methods Tumor growth was initiated by an intraperitoneal injection of EAC cells into C57BL/6J mice. Results 1) The M3 switch phenotype can be programed by activation of M1-reprogramming pathways with simultaneous inhibition of the M2 phenotype transcription factors, STAT3, STAT6, and/or SMAD3. 2) M3 macrophages exerted an anti-tumor effect both in vitro and in vivo, which was superior to anti-tumor effects of cisplatin or M1 macrophages. 3) The anti-tumor effect of M3 macrophages was due to their anti-proliferative effect. Conclusions Development of new biotechnologies for restriction of tumor growth using in vitro reprogrammed M3 macrophages is very promising. PMID:28123171

  9. Chemokine Binding Protein M3 of Murine Gammaherpesvirus 68 Modulates the Host Response to Infection in a Natural Host

    Science.gov (United States)

    Hughes, David J.; Kipar, Anja; Leeming, Gail H.; Bennett, Elaine; Howarth, Deborah; Cummerson, Joanne A.; Papoula-Pereira, Rita; Flanagan, Brian F.; Sample, Jeffery T.; Stewart, James P.

    2011-01-01

    Murine γ-herpesvirus 68 (MHV-68) infection of Mus musculus-derived strains of mice is an attractive model of γ-herpesvirus infection. Surprisingly, however, ablation of expression of MHV-68 M3, a secreted protein with broad chemokine-binding properties in vitro, has no discernable effect during experimental infection via the respiratory tract. Here we demonstrate that M3 indeed contributes significantly to MHV-68 infection, but only in the context of a natural host, the wood mouse (Apodemus sylvaticus). Specifically, M3 was essential for two features unique to the wood mouse: virus-dependent inducible bronchus-associated lymphoid tissue (iBALT) in the lung and highly organized secondary follicles in the spleen, both predominant sites of latency in these organs. Consequently, lack of M3 resulted in substantially reduced latency in the spleen and lung. In the absence of M3, splenic germinal centers appeared as previously described for MHV-68-infected laboratory strains of mice, further evidence that M3 is not fully functional in the established model host. Finally, analyses of M3's influence on chemokine and cytokine levels within the lungs of infected wood mice were consistent with the known chemokine-binding profile of M3, and revealed additional influences that provide further insight into its role in MHV-68 biology. PMID:21445235

  10. Chemokine binding protein M3 of murine gammaherpesvirus 68 modulates the host response to infection in a natural host.

    Directory of Open Access Journals (Sweden)

    David J Hughes

    2011-03-01

    Full Text Available Murine γ-herpesvirus 68 (MHV-68 infection of Mus musculus-derived strains of mice is an attractive model of γ-herpesvirus infection. Surprisingly, however, ablation of expression of MHV-68 M3, a secreted protein with broad chemokine-binding properties in vitro, has no discernable effect during experimental infection via the respiratory tract. Here we demonstrate that M3 indeed contributes significantly to MHV-68 infection, but only in the context of a natural host, the wood mouse (Apodemus sylvaticus. Specifically, M3 was essential for two features unique to the wood mouse: virus-dependent inducible bronchus-associated lymphoid tissue (iBALT in the lung and highly organized secondary follicles in the spleen, both predominant sites of latency in these organs. Consequently, lack of M3 resulted in substantially reduced latency in the spleen and lung. In the absence of M3, splenic germinal centers appeared as previously described for MHV-68-infected laboratory strains of mice, further evidence that M3 is not fully functional in the established model host. Finally, analyses of M3's influence on chemokine and cytokine levels within the lungs of infected wood mice were consistent with the known chemokine-binding profile of M3, and revealed additional influences that provide further insight into its role in MHV-68 biology.

  11. Printed Resources and Electronic Resources Integrated Services in Small and Medium-sized Libraries%中小型图书馆印本资源与电子资源一体化服务实践

    Institute of Scientific and Technical Information of China (English)

    刘胜

    2014-01-01

    Through analyzing the integrated service system of library resources, this paper sums up three methods for the integration of printed resources and digital resources including the digital resources catalog, digital resources navigate and open link system, and suggests that the libraries should give priority to books and periodicals integrated retrieval in the integrated service, and carry out the system construction within their capabilities by adopting the methods of making second development, introducing new system, and conducting independent development, etc.%通过对图书馆馆藏一体化服务系统的分析,归纳总结出印本资源与电子资源整合的3种主要模式———电子资源编目、电子资源导航与开放链接,并建议图书馆在进行一体化服务时,优先考虑图书和期刊的整合检索,在系统建设上量力而行,采取二次开发、引进新系统、自主开发等方式。

  12. 基于使用数据的馆藏电子资源评价方法与系统分析%Methods and Systems of Library Electronic Resources Evaluation Analysis Based on Usage Data

    Institute of Scientific and Technical Information of China (English)

    王丹丹

    2014-01-01

    The origin and methods of library electronic resources evaluation were summarized;the statistical standards of library users' us-age data were reviewed. Then four library electronic resources evaluation systems based on library users' usage data which are ScholarlyS-tats,Journal Use Reports,360 Counter and Ustat were compared and contrasted. The related work which librarians need to do and the con-sidering factors about the selection of electronic resources evaluation system was also analyzed.%总结了图书馆馆藏电子资源评价的缘起与方法,梳理了图书馆用户使用数据的统计规范。以此为基础对比了四个基于使用数据的馆藏电子资源评价系统---ScholarlyStats,Journal Use Reports,360 Counter,UStat,分析了图书馆选择电子资源评价系统的考虑因素和需要预先做好的相关工作。

  13. Soluble M3 proteins of murine gammaherpesviruses 68 and 72 expressed in Escherichia coli: analysis of chemokine-binding properties.

    Science.gov (United States)

    Matúšková, R; Pančík, P; Štibrániová, I; Belvončíková, P; Režuchová, I; Kúdelová, M

    2015-12-01

    M3 protein of murine gammaherpesvirus 68 (MHV-68) was identified as a viral chemokine-binding protein 3 (vCKBP-3) capable to bind a broad spectrum of chemokines and their receptors. During both acute and latent infection MHV-68 M3 protein provides a selective advantage for the virus by inhibiting the antiviral and inflammatory response. A unique mutation Asp307Gly was identified in the M3 protein of murine gammaherpesvirus 72 (MHV-72), localized near chemokine-binding domain. Study on chemokine-binding properties of MHV-72 M3 protein purified from medium of infected cells implied reduced binding to some chemokines when compared to MHV-68 M3 protein. It was suggested that the mutation in the M3 protein might be involved in the attenuation of immune response to infection with MHV-72. Recently, Escherichia coli cells were used to prepare native recombinant M3 proteins of murine gammaherpesviruses 68 and 72 (Pančík et al., 2013). In this study, we assessed the chemokine-binding properties of three M3 proteins prepared in E. coli Rosetta-gami 2 (DE3) cells, the full length M3 protein of both MHV-68 and MHV-72 and MHV-68 M3 protein truncated in the signal sequence (the first 24 aa). They all displayed binding activity to human chemokines CCL5 (RANTES), CXCL8 (IL-8), and CCL3 (MIP-1α). The truncated MHV-68 M3 protein had more than twenty times reduced binding activity to CCL5, but only about five and three times reduced binding to CXCL8 and CCL3 when compared to its full length counterpart. Binding of the full length MHV-72 M3 protein to all chemokines was reduced when compared to MHV-68 M3 protein. Its binding to CCL5 and CCL3 was reduced over ten and seven times. However, its binding to CXCL8 was only slightly reduced (64.8 vs 91.8%). These data implied the significance of the signal sequence and also of a single mutation (at aa 307) for efficient M3 protein binding to some chemokines.

  14. The BIOPAN experiment MARSTOX II of the FOTON M-3 mission

    Science.gov (United States)

    Rettberg, P.; Moeller, R.; Rabbow, E.; Panitz, C.; Horneck, G.; Meyer, C.; Lammer, H.; Douki, T.; Cadet, J.

    2008-09-01

    The experiment MARSTOX II on FOTON M-3 mission (September 14 - 26, 2007) was a further step in the study of the Responses of Organisms to the Martian Environment (ROME) which already started with first ground-based experiments in Mars simulation chambers and with the space experiment MARSTOX I, flown in 2005 in the ESA facility BIOPAN (Fig. 1) on FOTON M-2. The survivability of bacterial spores of B. subtilis, a well-characterized model system for highly resistant microorganisms, was investigated under the extreme environmental conditions as they exist on the surface of Mars. By use of exterrestrial UV radiation and cut-off filters the photoprotection and potential UV-phototoxicity of different minerals of the Martian soil were investigated.In MARSTOX II two further aspects were addressed (i) the influence of different concentrations of dust in the Martian atmosphere, which change the solar irradiance on the surface significantly compared to vacuum exposure under the same conditions (experiment parts 'DUST MARS' and 'DUST SPACE'), and (ii) the survivability of spores under martian atmosphere and pressure exposed to a mars-like spectral irradiance compared to vacuum exposure under the same conditions (experiment parts 'MIXED MARS' and 'MIXED SPACE') (Fig. 2 and 3). After exposure to space during the FOTON M-3 mission the sample analysis was performed at CEA in Grenoble, F, and at DLR in Cologne, D, together with parallel samples from the corresponding ground control experiment performed in the space simulation facilities at DLR. As biological endpoints in these investigations survival and UV-induced DNAphotoproducts were analysed.From the results of MARSTOX II the following conclusions can be drawn: (i) Spores mixed with martian soil analogue are protected only to a low degree against UV radiation. The protective effect of several defined layers of spores mixed with Martian soil analogue were quantified. (ii) The two investigated martian soil analogues, MRS07 (47

  15. CH5M3D: an HTML5 program for creating 3D molecular structures

    Science.gov (United States)

    2013-01-01

    Background While a number of programs and web-based applications are available for the interactive display of 3-dimensional molecular structures, few of these provide the ability to edit these structures. For this reason, we have developed a library written in JavaScript to allow for the simple creation of web-based applications that should run on any browser capable of rendering HTML5 web pages. While our primary interest in developing this application was for educational use, it may also prove useful to researchers who want a light-weight application for viewing and editing small molecular structures. Results Molecular compounds are drawn on the HTML5 Canvas element, with the JavaScript code making use of standard techniques to allow display of three-dimensional structures on a two-dimensional canvas. Information about the structure (bond lengths, bond angles, and dihedral angles) can be obtained using a mouse or other pointing device. Both atoms and bonds can be added or deleted, and rotation about bonds is allowed. Routines are provided to read structures either from the web server or from the user’s computer, and creation of galleries of structures can be accomplished with only a few lines of code. Documentation and examples are provided to demonstrate how users can access all of the molecular information for creation of web pages with more advanced features. Conclusions A light-weight (≈ 75 kb) JavaScript library has been made available that allows for the simple creation of web pages containing interactive 3-dimensional molecular structures. Although this library is designed to create web pages, a web server is not required. Installation on a web server is straightforward and does not require any server-side modules or special permissions. The ch5m3d.js library has been released under the GNU GPL version 3 open-source license and is available from http://sourceforge.net/projects/ch5m3d/. PMID:24246004

  16. Real-time monitoring of genetically modified Chlamydomonas reinhardtii during the Foton M3 space mission

    Science.gov (United States)

    Lambreva, M.; Rea, G.; Antonacci, A.; Serafini, A.; Damasso, M.; Pastorelli, S.; Margonelli, A.; Johanningmeier, U.; Bertalan, I.; Pezzotti, G.; Giardi, M. T.

    2008-09-01

    Long-term space exploration, colonization or habitation requires biological life support systems capable to cope with the deleterious space environment. The use of oxygenic photosynthetic microrganisms is an intriguing possibility mainly for food, O2 and nutraceutical compounds production. The critical points of utilizing plants- or algae-based life support systems are the microgravity and the ionizing radiation, which can influence the performance of these organisms. The aim of the present study was to assess the effects of space environment on the photosynthetic activity of various microrganisms and to select space stresstolerant strains. Photosystem II D1 protein sitedirected and random mutants of the unicellular green alga Chlamydomonas reinhardtii [1] were used as a model system to test and select the amino acid substitutions capable to account for space stress tolerance. We focussed our studies also on the accumulation of the Photosystem II photoprotective carotenoids (the xantophylls violaxanthin, anteraxanthin and zeaxanthin), powerful antioxidants that epidemiological studies demonstrated to be human vision protectors. For this purpose some mutants modified at the level of enzymes involved in the biosynthesis of xanthophylls were included in the study [2]. To identify the consequences of the space environment on the photosynthetic apparatus the changes in the Photosystem II efficiency were monitored in real time during the ESA-Russian Foton- M3 mission in September 2007. For the space flight a high-tech, multicell fluorescence detector, Photo-II, was designed and built by the Centre for Advanced Research in Space Optics in collaboration with Kayser-Italy, Biosensor and DAS. Photo-II is an automatic device developed to measure the chlorophyll fluorescence and to provide a living conditions for several different algae strains (Fig.1). Twelve different C. reinhardti strains were analytically selected and two replications for each strain were brought to space

  17. A miniaturized microbial fuel cell with three-dimensional graphene macroporous scaffold anode demonstrating a record power density of over 10 000 W m-3

    Science.gov (United States)

    Ren, Hao; Tian, He; Gardner, Cameron L.; Ren, Tian-Ling; Chae, Junseok

    2016-02-01

    A microbial fuel cell (MFC) is a bio-inspired renewable energy converter which directly converts biomass into electricity. This is accomplished via the unique extracellular electron transfer (EET) of a specific species of microbe called the exoelectrogen. Many studies have attempted to improve the power density of MFCs, yet the reported power density is still nearly two orders of magnitude lower than other power sources/converters. Such a low performance can primarily be attributed to two bottlenecks: (i) ineffective electron transfer from microbes located far from the anode and (ii) an insufficient buffer supply to the biofilm. This work takes a novel approach to mitigate these two bottlenecks by integrating a three-dimensional (3D) macroporous graphene scaffold anode in a miniaturized MFC. This implementation has delivered the highest power density reported to date in all MFCs of over 10 000 W m-3. The miniaturized configuration offers a high surface area to volume ratio and improved mass transfer of biomass and buffers. The 3D graphene macroporous scaffold warrants investigation due to its high specific surface area, high porosity, and excellent conductivity and biocompatibility which facilitates EET and alleviates acidification in the biofilm. Consequently, the 3D scaffold houses an extremely thick and dense biofilm from the Geobacter-enriched culture, delivering an areal/volumetric current density of 15.51 A m-2/31 040 A m-3 and a power density of 5.61 W m-2/11 220 W m-3, a 3.3 fold increase when compared to its planar two-dimensional (2D) control counterparts.A microbial fuel cell (MFC) is a bio-inspired renewable energy converter which directly converts biomass into electricity. This is accomplished via the unique extracellular electron transfer (EET) of a specific species of microbe called the exoelectrogen. Many studies have attempted to improve the power density of MFCs, yet the reported power density is still nearly two orders of magnitude lower than

  18. Analysis on Current Situation and Countermeasure of Domestic Electronic Commerce Logistics in the Internet Age——Based on Resource Dependence Theory

    Directory of Open Access Journals (Sweden)

    Zhang Jiapeng

    2017-01-01

    Full Text Available This paper analyzes the status of electric business logistics in the current Internet era in China, and combines the SWOT analysis with AHP to do the empirical analysis, then puts forward the countermeasure that the electric business logistics resource should be shared based on the resource dependence theory. Through the empirical analysis, it is found that the disadvantages and opportunities of the logistics status are important in the Internet era.The resource sharing strategy based on the resource dependence theory is more scientific. The rational use of Internet technology in electric business logistics industry can achieve “sharing”. It is of great significance for its balanced development, intelligent development and optimization and development.

  19. The Swift/UVOT Stars Survey. II. RR Lyrae Stars in M 3 and M 15

    CERN Document Server

    Siegel, Michael H; Balzer, Benjamin G; Hagen, Lea M Z

    2015-01-01

    We present the first results of an near-ultraviolet (NUV) survey of RR Lyrae stars from the Ultraviolet Optical Telescope (UVOT) aboard the Swift Gamma-Ray Burst Mission. It is well-established that RR Lyrae have large amplitudes in the far- and near-ultraviolet. We have used UVOT's unique wide-field NUV imaging capability to perform the first systematic NUV survey of variable stars in the Galactic globular clusters M 3 and M 15. We identify 280 variable stars, comprising 275 RR Lyrae, two anomalous Cepheids, one classical Cepheid, one SX Phoenicis star and one possible long-period or irregular variable. Only two of these are new discoveries. We compare our results to previous investigations and find excellent agreement in the periods with significantly larger amplitudes in the NUV. We map out, for the first time, an NUV Bailey diagram from globular clusters, showing the usual loci for fundamental mode RRab and first overtone RRc pulsators. We show the unique sensitivity of NUV photometry to both the temperat...

  20. THE SWIFT UVOT STARS SURVEY. II. RR LYRAE STARS IN M3 AND M15

    Energy Technology Data Exchange (ETDEWEB)

    Siegel, Michael H.; Porterfield, Blair L.; Balzer, Benjamin G.; Hagen, Lea M. Z., E-mail: siegel@astro.psu.edu, E-mail: blp14@psu.edu, E-mail: bgb5080@psu.edu, E-mail: lea.zernow.hagen@gmail.com [Pennsylvania State University, Department of Astronomy, 525 Davey Laboratory, University Park, PA 16802 (United States)

    2015-10-15

    We present the first results of a near-ultraviolet (NUV) survey of RR Lyrae stars from the Ultraviolet Optical Telescope (UVOT) on board the Swift Gamma-ray Burst Mission. It is well-established that RR Lyrae stars have large amplitudes in the far- and near-ultraviolet. We have used UVOT’s unique wide-field NUV imaging capability to perform the first systematic NUV survey of variable stars in the Galactic globular clusters M3 and M15. We identify 280 variable stars, comprised of 275 RR Lyrae, 2 anomalous Cepheids, 1 classical Cepheid, 1 SX Phoenicis star, and 1 possible long-period or irregular variable. Only two of these are new discoveries. We compare our results to previous investigations and find excellent agreement in the periods with significantly larger amplitudes in the NUV. We map out, for the first time, an NUV Bailey diagram from globular clusters, showing the usual loci for fundamental mode RRab and first overtone RRc pulsators. We show the unique sensitivity of NUV photometry to both the temperatures and the surface gravities of RR Lyrae stars. Finally, we show evidence of an NUV period–metallicity–luminosity relationship. Future investigations will further examine the dependence of NUV pulsation parameters on metallicity and Oosterhoff classification.

  1. Molecular Modeling of the M3 Acetylcholine Muscarinic Receptor and Its Binding Site

    Science.gov (United States)

    Martinez-Archundia, Marlet; Cordomi, Arnau; Garriga, Pere; Perez, Juan J.

    2012-01-01

    The present study reports the results of a combined computational and site mutagenesis study designed to provide new insights into the orthosteric binding site of the human M3 muscarinic acetylcholine receptor. For this purpose a three-dimensional structure of the receptor at atomic resolution was built by homology modeling, using the crystallographic structure of bovine rhodopsin as a template. Then, the antagonist N-methylscopolamine was docked in the model and subsequently embedded in a lipid bilayer for its refinement using molecular dynamics simulations. Two different lipid bilayer compositions were studied: one component palmitoyl-oleyl phosphatidylcholine (POPC) and two-component palmitoyl-oleyl phosphatidylcholine/palmitoyl-oleyl phosphatidylserine (POPC-POPS). Analysis of the results suggested that residues F222 and T235 may contribute to the ligand-receptor recognition. Accordingly, alanine mutants at positions 222 and 235 were constructed, expressed, and their binding properties determined. The results confirmed the role of these residues in modulating the binding affinity of the ligand. PMID:22500107

  2. [Gerbil experiment in the flight of spacecraft "Foton-M3"].

    Science.gov (United States)

    Il'in, E A; Smirnov, I A; Soldatov, P E; Orlov, O I

    2009-01-01

    The 12-d mission of Russian spacecraft Foton-M3 in September of 2007 was used as an opportunity to fly an experiment with 12 male gerbils (Meriones unguiculatus) at the age of 4-4.5 mos. and mean body weight of 51.6 grams. Considering the behavior pattern of these animals, selection and preparation of the experimental groups continued in the course of 2.5-3 months. The flight animals were contained in module Kontur-L outfitted with a self-sustained system of life support. In orbit, the animals received a palletized hydrogenous feed. The physiological and hygienic parameters of the gerbil environment during the flight complied with the official standards. Analysis of the video recorded behavior of animals in microgravity showed that virtually throughout the flight they moved chaotically along the cage never attempting to stabilize position catching at the wire netting of the cage. The animals were decapitated in 21-24 hours after landing. The investigations showed that structural and functional changes in gerbil organs and tissues were generally of the same type as in rats following fights of comparable duration. However, some differences between the animals were attributed to the specifics of water turnover in gerbils.

  3. [Handling and maintenance of gerbils during the spacecraft Foton-M3 mission].

    Science.gov (United States)

    Soldatov, P E; Smirnov, I A; Il'in, E A; Gur'eva, T S; Mednikova, E I; Smolenskaia, T S; Lysenko, L A; Kaminskaia, E V

    2009-01-01

    Pressurized low-sized module Kontur with an independent life support system (LSS) was developed by the Institute of Biomedical Problems cooperatively with the Special Design Bureau of Experimental Equipment to house gerbils (Meriones unguiculatus) aboard robotic technology-purpose spacecraft. Design of the module precludes pollution of the environment The fully equipped module weighs 69 kg; average daily power consumption is 62 watts. The environmental parameters for 12 animals flown on Foton-M3 in the period of September 14-26, 2007 were controlled within the following ranges: pO2 - 143-156 mm Hg, (mean 150 mm Hg), pCO2 - 0.76 mm Hg maximum (mean 0.64 mm Hg), temperature - 23-28 degrees C (mean 26.7 degrees C), relative humidity - 29% and 57% at the beginning and end of the flight, respectively (mean 39%). The animals consumed the palletized food prepared of natural products with a moisture content of approx. 20%. The day-night periods were 12 hrs. long. The daytime video recording of the animals went on continuously in the throughout the flight. The experiment showed that the module meets the requirements of experiments with mammals aboard returnable robotic spacecraft and piloted space stations. At the moment, the model is being redesigned for a 30-day BION-M1 mission.

  4. [Glycogen content in gerbil's liver following the spacecraft Foton-M3 mission].

    Science.gov (United States)

    Atiakshin, D A; Bykov, E G; Il'in, E A; Pashkov, A N

    2009-01-01

    Glycogen cytochemistry and distribution in hepatocytes of the classic liver lobules were studied in three groups of gerbils Meriones unguiculatus: vivarium, synchronous control and flown in the 12-d Foton-M3 mission. The control animals were shown to have the central glycogen distribution with a large pool of polysaccharides found in hepatocytes of the pericentral and intermediate lobules and a small pool in the periportal area. Glycogen in hepatocyte plasm was within the physiological norm in the alpha- and beta-granules, typically localized on the cell periphery. Exposure to the spaceflight conditions decreased significantly glycogen concentrations in each functional region of the hepatic lobules and reduced the gradient of polysaccharide distribution from the portal triads toward the central vein. In parallel, high glycogen heterogeneity formed in adjacent hepatocytes and loci. The presence of glycosomes evidenced disturbance of carbohydrates metabolism. In addition, intracellular topography of glycogen granules in cytoplasm was altered. Trends of glycogen in gerbils of the synchronous control were similar to the space flown animals but much less pronounced.

  5. [Jejunum intersticium in mongolian gerbils after the flight on spacecraft Foton-M3].

    Science.gov (United States)

    Atiashkin, D A; Bykov, É G; Il'in, E A; Pashkov, A N

    2012-01-01

    Methods of light optical microscopy were used to explore histoarchitectonics, topography and tinctorial properties of the extracellular phase of fibers of jejunum wall intersticium in Mongolian gerbils following 12-day orbital flight aboard Foton-M3, ground-based simulation of the spaceflight factors in the KONTUR-L facility, and in the group of biological control Postflight destructive changes were found in reticulin fibers (type-III collagen) of villi stroma, intercrypt intersticium and submucosa. Local acidophilia and fiber homogenization formed in type I collagen present in the intestinal subserous layer, muscular layers endomysium and submucose against the background of progressing edema and arterial, venous plethora and lymphostasis. Elastic component of the intersticium was disarranged in the structures of internal elastic membrane of submucous vessels, fragmented and partly reduced. Simulation of the orbital factors, except for microgravity, in the KONTUR-L facility called forth similar, although less often and diffuse, changes in intersticium fibers. The results of examination of intestinal intersticium fibers in the vivarium control gerbils discovered expressed species characters that should be taken into account by investigators, especially when comparing with data obtained from other animal species.

  6. [Rna content of gerbil hepatocytes after the flight aboard space platform Foton-M3].

    Science.gov (United States)

    Atiashkin, D A; Bykov, E G; Il'in, E A; Pashkov, A N

    2010-01-01

    The paper compares and contrasts the results of measuring the hepatocyte cytoplasm area and RNA content in 35 gerbils in three series of experiments, i.e. the vivarium control, modeled space flight (synchronous control) and exposure to the factors of 12-d Foton-M3 orbital flight. Central, intermediate and peripheral zones of hepatic lobes were subjected to histological and histochemical analyses to measure the hepatocyte cytoplasm area; the RNA content was determined from the level of cytoplasm basophilia after azure staining. Cytometric and cytophotometric investigations were performed using image analyzer Video-7-Test-Morpho. In the vivarium animals, hepatocytes with the largest cytoplasm localized predominantly in the intermediate and central zones of the lobes. Judging from the results of microdensitometry, the RNA content was particularly high in binucleate hepatocytes of the intermediate zone. In the synchronous control, hepatocytes tended to grow in size, in the peripheral zone specifically, whereas RNA content was largely equal no matter hepatocyte topography. After space flight, cytoplasm enlargement transcended this process in the vivarium animals. The cytoplasm RNA content along the entire liver parenchyma made a significant decrease equally as compared with the vivarium and synchronous control animals.

  7. Molecular Modeling of the M3 Acetylcholine Muscarinic Receptor and Its Binding Site

    Directory of Open Access Journals (Sweden)

    Marlet Martinez-Archundia

    2012-01-01

    Full Text Available The present study reports the results of a combined computational and site mutagenesis study designed to provide new insights into the orthosteric binding site of the human M3 muscarinic acetylcholine receptor. For this purpose a three-dimensional structure of the receptor at atomic resolution was built by homology modeling, using the crystallographic structure of bovine rhodopsin as a template. Then, the antagonist N-methylscopolamine was docked in the model and subsequently embedded in a lipid bilayer for its refinement using molecular dynamics simulations. Two different lipid bilayer compositions were studied: one component palmitoyl-oleyl phosphatidylcholine (POPC and two-component palmitoyl-oleyl phosphatidylcholine/palmitoyl-oleyl phosphatidylserine (POPC-POPS. Analysis of the results suggested that residues F222 and T235 may contribute to the ligand-receptor recognition. Accordingly, alanine mutants at positions 222 and 235 were constructed, expressed, and their binding properties determined. The results confirmed the role of these residues in modulating the binding affinity of the ligand.

  8. [2 fatal cases of acute myeloid leukemia (M3, M4) during pregnancy].

    Science.gov (United States)

    Aragona, M; Asmundo, A

    1995-04-01

    Two cases of unexpected post-partum death of women with acute leukemia are described. In the first case (1st pregnancy) the diagnosis (acute promyelocytic leukemia: M3) was performed one week before delivery and death occurred 3 days later, because of hemorrhagic and renal DIC complication. Since one month before hospitalization, laboratory exams indicated a serious hematological pathology and no further exams were carried out by the physicians, elements of professional fault were recognized in them, considering that because of the diagnostic omission it was impossible to make an early diagnosis and thus perform to specific therapy, adopted only in the terminal phase. This specific therapy is able to determine remission from most cases of acute promyelocytic leukemia. In the second case (2nd pregnancy) the diagnosis (acute myelomonocytic leukemia: M4) was performed only postmortem because, during the whole pregnancy, no signs of disease were evident. After a few hours from the spontaneous delivery, death occurred as a result of an intractable + hemorrhagic syndrome caused by primary hyperfibrinolysis and repeated episodes of cardiac arrest, without possibility of recognizing it. The medical procedures for this case, both throughout pregnancy and terminal phases, appeared free of censure.

  9. Experimental Study of Ultralight (<300 kg/m3 Foamed Concrete

    Directory of Open Access Journals (Sweden)

    Xianjun Tan

    2014-01-01

    Full Text Available A type of ultralight (<300 kg/m3 foamed concrete (FC, which can be used as a new energy-conservation and environmental-protection building material and is particularly suitable for the thermal-insulation engineering of building external walls, was produced. The influences of different mixing amounts of fly ash, fly ash activator, WC (WC ratio, and foaming agent (FA on the compressive strength of FC were reported. The experimental study indicated that (1 the addition of fly ash reduced the strength of the FC and that the appropriate mixing amount of fly ash in this ultralight FC system should not exceed 45%; (2 with the increasing of fly ash activator, the strength of the FC sample is notably enhanced and the appropriate mixing amount of fly ash activator is 2.5%; (3 the optimized proportion of WC ratio is 0.45, and the FC that was produced according to this proportion has relatively high compressive strength; (4 by increasing the mixing amount of FA, the compressive strength of the FC notably decreases, and the optimal mixing amount of FA in this experiment is 3.5%.

  10. Discovery of a wide planetary-mass companion to the young M3 star GU PSC

    Energy Technology Data Exchange (ETDEWEB)

    Naud, Marie-Eve; Artigau, Étienne; Malo, Lison; Albert, Loïc; Doyon, René; Lafrenière, David; Gagné, Jonathan; Boucher, Anne [Département de physique and Observatoire du Mont-Mégantic, Université de Montréal, Montréal H3C 3J7 (Canada); Saumon, Didier [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Morley, Caroline V. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Allard, France; Homeier, Derek [Centre de Recherche Astrophysique de Lyon, UMR 5574 CNRS, Université de Lyon, École Normale Supérieure de Lyon, 46 Allée d' Italie, F-69364 Lyon Cedex 07 (France); Beichman, Charles A.; Gelino, Christopher R., E-mail: naud@astro.umontreal.ca [Infrared Processing and Analysis Center, MS 100-22, California Institute of Technology, Pasadena, CA 91125 (United States)

    2014-05-20

    We present the discovery of a comoving planetary-mass companion ∼42'' (∼2000 AU) from a young M3 star, GU Psc, a likely member of the young AB Doradus Moving Group (ABDMG). The companion was first identified via its distinctively red i – z color (>3.5) through a survey made with Gemini-S/GMOS. Follow-up Canada-France-Hawaii Telescope/WIRCam near-infrared (NIR) imaging, Gemini-N/GNIRS NIR spectroscopy and Wide-field Infrared Survey Explorer photometry indicate a spectral type of T3.5 ± 1 and reveal signs of low gravity which we attribute to youth. Keck/Adaptive Optics NIR observations did not resolve the companion as a binary. A comparison with atmosphere models indicates T {sub eff} = 1000-1100 K and log g = 4.5-5.0. Based on evolution models, this temperature corresponds to a mass of 9-13 M {sub Jup} for the age of ABDMG (70-130 Myr). The relatively well-constrained age of this companion and its very large angular separation to its host star will allow its thorough characterization and will make it a valuable comparison for planetary-mass companions that will be uncovered by forthcoming planet-finder instruments such as Gemini Planet Imager and SPHERE 9.

  11. Magnetic and dynamical photospheric disturbances observed during an M3.2 solar flare

    CERN Document Server

    Kuckein, C; Sainz, R Manso

    2015-01-01

    This letter reports on a set of full-Stokes spectropolarimetric observations in the near infrared He I 10830 A spectral region covering the pre-, flare, and post-flare phases of an M3.2 class solar flare. The flare originated on 2013 May 17 and belonged to active region NOAA 11748. We detected strong He I 10830 A emission in the flare. The red component of the He I triplet peaks at an intensity ratio to the continuum of about 1.86. During the flare, He I Stokes V is substantially larger and appears reversed compared to the usually larger Si I Stokes V profile. The photospheric Si I inversions of the four Stokes profiles reveal the following: (1) the magnetic field strength in the photosphere decreases or is even absent during the flare phase, as compared to the pre-flare phase. However, this decrease is not permanent. After the flare the magnetic field recovers its pre-flare configuration in a short time (i.e., in 30 minutes after the flare). (2) In the photosphere, the line-of-sight velocities show a regular...

  12. GRAVITAS : General Relativistic Astrophysics VIa Timing And Spectroscopy: An ESA M3 mission proposal

    CERN Document Server

    Nandra, Kirpal; Fabian, Andy; Strueder, Lothar; Willingale, Richard; Watson, Mike; Jonker, Peter; Kunieda, Hideyo; Miniutti, Giovanni; Motch, Christian; Predehl, Peter

    2011-01-01

    GRAVITAS is an X-ray observatory, designed and optimised to address the ESA Cosmic Vision theme of "Matter under extreme conditions". It was submitted as a response to the call for M3 mission proposals. The concept centres around an X-ray telescope of unprecedented effective area, which will focus radiation emitted from close to the event horizon of black holes or the surface of neutron stars. To reveal the nature and behaviour of matter in the most extreme astrophysical environments, GRAVITAS targets a key feature in the X-ray spectra of compact objects: the iron Kalpha line at ~6.5 keV. The energy, profile, and variability of this emission line, and the properties of the surrounding continuum emission, shaped by General Relativity (GR) effects, provide a unique probe of gravity in its strong field limit. Among its prime targets are hundreds of supermassive black holes in bright Active Galactic Nuclei (AGN), which form the perfect laboratory to help understand the physical processes behind black hole growth....

  13. Overtone and multi-mode RR Lyrae stars in the globular cluster M3

    CERN Document Server

    Jurcsik, J; Hajdu, G; Sódor, Á; Nuspl, J; Kolenberg, K; Fűrész, G; Moór, A; Kun, E; Pál, A; Bakos, J; Kelemen, J; Kovács, T; Kriskovics, L; Sárneczky, K; Szalai, T; Szing, A; Vida, K

    2015-01-01

    The overtone and multi-mode RR Lyrae stars in the globular cluster M3 are studied using a 200-d long, $B,V$ and $I_{\\mathrm C}$ time-series photometry obtained in 2012. 70\\% of the 52 overtone variables observed show some kind of multi-periodicity (additional frequency at ${f_{0.61}}={f_{\\mathrm {1O}}}/0.61$ frequency ratio, Blazhko effect, double/multi-mode pulsation, period doubling). A signal at 0.587 frequency ratio to the fundamental-mode frequency is detected in the double-mode star, V13, which may be identified as the second radial overtone mode. If this mode-identification is correct, than V13 is the first RR Lyrae star showing triple-mode pulsation of the first three radial modes. Either the Blazhko effect or the ${f_{0.61}}$ frequency (or both of these phenomena) appear in 7 double-mode stars. The $P_{\\mathrm{1O}}/P_{\\mathrm{F}}$ period ratio of RRd stars showing the Blazhko effect are anomalous. A displacement of the main frequency component at the fundamental-mode with the value of modulation freq...

  14. Discovery of a wide planetary-mass companion to the young M3 star GU Psc

    CERN Document Server

    Naud, Marie-Eve; Malo, Lison; Albert, Loïc; Doyon, René; Lafrenière, David; Gagné, Jonathan; Saumon, Didier; Morley, Caroline V; Allard, France; Homeier, Derek; Beichman, Charles A; Gelino, Christopher R; Boucher, Anne

    2014-01-01

    We present the discovery of a co-moving planetary-mass companion ~42" (~2000 AU) from a young M3 star, GU Psc, likely member of the young AB Doradus Moving Group (ABDMG). The companion was first identified via its distinctively red i - z color (> 3.5) through a survey made with Gemini-S/GMOS. Follow-up Canada-France-Hawaii Telescope/WIRCam near-infrared (NIR) imaging, Gemini-N/GNIRS NIR spectroscopy and Wide-field Infrared Survey Explorer photometry indicate a spectral type of T3.5+-1 and reveal signs of low gravity which we attribute to youth. Keck/Adaptive Optics NIR observations did not resolve the companion as a binary. A comparison with atmosphere models indicates Teff = 1000-1100 K and logg = 4.5-5.0. Based on evolution models, this temperature corresponds to a mass of 9-13 MJup for the age of ABDMG (70-130 Myr). The relatively well-constrained age of this companion and its very large angular separation to its host star will allow its thorough characterization and will make it a valuable comparison for ...

  15. IFR safety tests M2 and M3 in TREAT: data and analysis

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, W R; Lo, R K; Bauer, T H; Froehle, P H; Helenberg, H W; Morman, J A; Stanford, G S; Wright, A E

    1985-06-01

    TREAT tests M2 and M3 were performed to obtain information on the characteristics of metal-alloy reactor fuel under slow transient overpower accident conditions, in particular, the margin to cladding breach and the axial self-extrusion of fuel within intact cladding. The tests used U-5Fs fuel pins irradiated to burnup levels of 0.3 at. %, 4.5 at. % and 7.9 at. %. Each pin was located in a separte flowtube and cooled by flowing sodium. In one test, a pin of each burnup was heated to incipient cladding breach. In the other, pins of the medium and high burnup levels wer heated to slightly beyond breach. Pre- and post-failure fuel motions were monitored by the fast-neutron hodoscope. The time and axial location of cladding breach were determined from the test-loop instrumentation. Computations of fuel extrusion and cladding failure are desribed. The models used in the computations include effects of retained fission gas expansion, vaporization of the sodium-bond annulus in low burnup fuel, and cladding-wall thinning by eutectic formation.

  16. Comparison of human and porcine gastric clasp and sling fiber contraction by M2 and M3 muscarinic receptors.

    Science.gov (United States)

    Vegesna, Anil K; Braverman, Alan S; Miller, Larry S; Tallarida, Ronald J; Tiwana, Mansoor I; Khayyam, Umar; Ruggieri, Michael R

    2010-04-01

    To compare the gastroesophageal junction of the human with the pig, M(2) and M(3) receptor densities and the potencies of M(2) and M(3) muscarinic receptor subtype selective antagonists were determined in gastric clasp and sling smooth muscle fibers. Total muscarinic and M(2) receptors are higher in pig than human clasp and sling fibers. M(3) receptors are higher in human compared with pig sling fibers but lower in human compared with pig clasp fibers. Clasp fibers have fewer M(3) receptors than sling fibers in both humans and pigs. Similar to human clasp fibers, pig clasp fibers contract significantly less than pig sling fibers. Analysis of the methoctramine Schild plot suggests that M(2) receptors are involved in mediating contraction in pig clasp and sling fibers. Darifenacin potency suggests that M(3) receptors mediate contraction in pig sling fibers and that M(2) and M(3) receptors mediate contraction in pig clasp fibers. Taken together, the data suggest that both M(2) and M(3) muscarinic receptors mediate the contraction in both pig clasp and sling fibers similar to human clasp and sling fibers.

  17. Fiber resources

    Science.gov (United States)

    P. J. Ince

    2004-01-01

    In economics, primary inputs or factors of production define the term ‘resources.’ Resources include land resources (plants, animals, and minerals), labor, capital, and entrepreneurship. Almost all pulp and paper fiber resources are plant materials obtained from trees or agricultural crops. These resources encompass plant materials harvested directly from the land (...

  18. MAGNETIC AND DYNAMICAL PHOTOSPHERIC DISTURBANCES OBSERVED DURING AN M3.2 SOLAR FLARE

    Energy Technology Data Exchange (ETDEWEB)

    Kuckein, C. [Leibniz-Institut für Astrophysik Potsdam (AIP), An der Sternwarte 16, D-14482, Potsdam (Germany); Collados, M.; Sainz, R. Manso, E-mail: ckuckein@aip.de [Instituto de Astrofísica de Canarias (IAC), Vía Láctea s/n, E-38205, La Laguna, Tenerife (Spain)

    2015-02-01

    This Letter reports on a set of full-Stokes spectropolarimetric observations in the near-infrared He i 10830 Å spectral region covering the pre-flare, flare, and post-flare phases of an M3.2 class solar flare. The flare originated on 2013 May 17 and belonged to active region NOAA 11748. We detected strong He i 10830 Å emission in the flare. The red component of the He i triplet peaks at an intensity ratio to the continuum of about 1.86. During the flare, He i Stokes V is substantially larger and appears reversed compared to the usually larger Si i Stokes V profile. The photospheric Si i inversions of the four Stokes profiles reveal the following: (1) the magnetic field strength in the photosphere decreases or is even absent during the flare phase, as compared to the pre-flare phase. However, this decrease is not permanent. After the flare, the magnetic field recovers its pre-flare configuration in a short time (i.e., 30 minutes after the flare). (2) In the photosphere, the line of sight velocities show a regular granular up- and downflow pattern before the flare erupts. During the flare, upflows (blueshifts) dominate the area where the flare is produced. Evaporation rates of ∼10{sup −3} and ∼10{sup −4} g cm{sup −2} s{sup −1} have been derived in the deep and high photosphere, respectively, capable of increasing the chromospheric density by a factor of two in about 400 s.

  19. Signal transduction by M3 muscarinic acetylcholine receptor in prostate cancer

    Science.gov (United States)

    GUO, LIQIANG; LIU, YUQIANG; DING, ZHIBO; SUN, WENDONG; YUAN, MINGZHEN

    2016-01-01

    The present study aimed to investigate the potential mechanisms used during signal transduction by M3 muscarinic acetylcholine receptor (CHRM3) in prostate cancer. The microarray datasets of GSE3325, including 5 clinically localized primary prostate cancers and 4 benign prostate tissues, were downloaded from the Gene Expression Omnibus database. The differentially-expressed genes (DEGs) in primary prostate cancer tissues compared with benign controls were screened using the Limma package. Gene Ontology and pathway enrichment analyses were performed using the Database for Annotation Visualization and Integrated Discovery. Next, a protein-protein interaction (PPI) network was constructed. Additionally, microRNAs (miRNAs) associated with DEGs were predicted and miRNA-target DEG analysis was performed using a Web-based Gene Set Analysis Toolkit. Finally, the PPI network and the miRNA-target DEG network were integrated using Cytoscape. In total, 224 DEGs were screened in the prostate cancer tissues, including 113 upregulated and 111 downregulated genes. CHRM3 and epidermal growth factor (EGF) were enriched in the regulation of the actin cytoskeleton. EGF and v-myc avian myelocytomatosis viral oncogene homolog (Myc) were enriched in the mitogen-activated protein kinase (MAPK) signaling pathway. EGF with the highest degree of connectivity was the hub node in the PPI network, and miR-34b could interact with Myc directly in the miRNA-target DEG network. EGF and Myc may exhibit significant roles in the progression of prostate cancer via regulation of the actin cytoskeleton and the MAPK signaling pathway. CHRM3 may activate these two pathways in prostate cancer progression. Thus, these two key factors and pathways may be crucial mechanisms during signal transduction by CHRM3 in prostate cancer. PMID:26870222

  20. Simulation of VANAM M3 test using MELCOR 1.8.3

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Sung Won; Kim, Hee Dong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1996-07-01

    A standard problem is defined as a comparison between experimental and analytical results in the field of reactor safety research. The detailed comparison of the data permits conclusions for the reliability and precision of computer simulations of postulated accidents and contributions to the development and improvement of reactor safety computer codes. Following a suggestion of the Federal Republic of Germany, the OECD-CSNI agreed to offer the experiment VANAM M3 at the Battelle Model Containment (BMC), an experiment on thermohydraulics and aerosol behavior in a containment, as International Standard Problem No. 37 (ISP 37). The general objectives of the ISP 37 are to analyse the thermohydraulics of a containment atmosphere and the distribution and settlement of aerosol after a high pressure path with depressurization by pressurizer relief valve discharge. Steam condensation at the aerosol particles(condensation in volume) is enhanced by the hygroscopic properties of the aerosol materials, even in case of limited steam supply. The originally small, low-density NaOH particles are converted to solution droplets by steam condensation, the increasing droplet mass significantly enhancing aerosol depletion by gravity settlement. As a result, higher depletion rate have been obtained for the NaOH aerosol than for the SnO{sub 2} aerosol in M2. The MELCOR code, version 1.8.3, has been used for the simulation of this experiment, and the results are compared with the results of other calculations at GRS. The objectives of this report are to contribute to the efficient use of MELCOR code and understanding of the aerosol behavior. 12 tabs., 19 figs., 11 refs. (Author).

  1. Agronomic Characterization of Wheat Mutants (Triticum aestivum of M3 Generation Planted in Sukabumi

    Directory of Open Access Journals (Sweden)

    Laela Sari

    2016-11-01

    Full Text Available The purpose of this study was to identify the selection criteria to obtain a superior mutant derived from the wheat plants of such varieties as Dewata, Selayar and Alibey, adaptive in medium land. The analysis of agronomic growth characters showed a significantly effect on a growth percentage of the initial growth (8 mutants, flowering time (1 mutant, panicle stem length (15 mutants, number of panicles (7 mutants, the number of grains per panicle (8 mutants, grain weight observed (8 mutants, grain weight per genotype (6 mutants, leaf area (2 mutants and leaf greenness (5 mutants. The effects on the characters of ripe time, harvest, panicle length and plant height were not significant. The mutants of Dewata, Selayar and Alibey could be selected based on the characters of panicle stem length, number of grains per panicle and grain weight per observation because these characters generated more mutants than the other characters. The correlation analysis between the characters of growth and yield components of wheat mutants showed that the number of grains per panicle was positively correlated with the grain weight observed, while the length of panicle stem was positively correlated with grain weight per genotype, number of panicles and leaf area. Hopefully some mutants produced could adapt to the tropical medium land, thus adding to the diversity of wheat germplasm in Indonesia, thereby reducing the import of wheat to Indonesia.How to CiteSari, L., Purwito, A., Sopandie, D., Purnamaningsih, R. & Sudarmonowati, E. (2016. Agronomic Characterization of Wheat Mutants (Triticum aestivum of M3 Generation Planted in Sukabumi. Biosaintifika: Journal of Biology & Biology Education, 8(3, 353-361. 

  2. Remote compositional analysis of lunar olivine-rich lithologies with Moon Mineralogy Mapper (M3) spectra

    Science.gov (United States)

    Isaacson, P.J.; Pieters, C.M.; Besse, S.; Clark, R.N.; Head, J.W.; Klima, R.L.; Mustard, J.F.; Petro, N.E.; Staid, M.I.; Sunshine, J.M.; Taylor, L.A.; Thaisen, K.G.; Tompkins, S.

    2011-01-01

    A systematic approach for deconvolving remotely sensed lunar olivine-rich visible to near-infrared (VNIR) reflectance spectra with the Modified Gaussian Model (MGM) is evaluated with Chandrayaan-1 Moon Mineralogy Mapper (M 3) spectra. Whereas earlier studies of laboratory reflectance spectra focused only on complications due to chromite inclusions in lunar olivines, we develop a systematic approach for addressing (through continuum removal) the prominent continuum slopes common to remotely sensed reflectance spectra of planetary surfaces. We have validated our continuum removal on a suite of laboratory reflectance spectra. Suites of olivine-dominated reflectance spectra from a small crater near Mare Moscoviense, the Copernicus central peak, Aristarchus, and the crater Marius in the Marius Hills were analyzed. Spectral diversity was detected in visual evaluation of the spectra and was quantified using the MGM. The MGM-derived band positions are used to estimate the olivine's composition in a relative sense. Spectra of olivines from Moscoviense exhibit diversity in their absorption features, and this diversity suggests some variation in olivine Fe/Mg content. Olivines from Copernicus are observed to be spectrally homogeneous and thus are predicted to be more compositionally homogeneous than those at Moscoviense but are of broadly similar composition to the Moscoviense olivines. Olivines from Aristarchus and Marius exhibit clear spectral differences from those at Moscoviense and Copernicus but also exhibit features that suggest contributions from other phases. If the various precautions discussed here are weighed carefully, the methods presented here can be used to make general predictions of absolute olivine composition (Fe/Mg content). Copyright ?? 2011 by the American Geophysical Union.

  3. On the development and the utilization of library holding in electronic resources Taking the Library of Shandong University of Science and Technology%试论电子资源的馆藏发展与利用——以山东科技大学图书馆为例

    Institute of Scientific and Technical Information of China (English)

    陈明华; 马圣芹

    2012-01-01

    通过分析电子资源馆藏发展的意义及模式,对电子资源发展的目标及有效管理进行了探讨,并提出一些提高电子资源利用率的措施。%This paper analyses the mode and the importance of library holding development in electronic resources. It also ex- plores the aim and the affective management in electronic resource development and put forwards some measures to improve the utilization ratio of electronic resources.

  4. 基于Cortex-M3的电池内阻检测系统设计与实现%Design and implementation of battery internal resistance detection system based on Cortex-M3

    Institute of Scientific and Technical Information of China (English)

    张乐芳; 荆炳礼; 任志宏

    2015-01-01

    以电池为能源的各类电气设备,在工业生产、交通、军事、通信等领域广泛应用,电池性能对电子、电气设备的正常运行具有极其重要的作用。电池在使用过程中,其性能和容量会随充放电次数的增加而下降,所以,定期维护及检验电池性能,是保证电器设备可靠工作的重要内容。电池内阻是检验电池性能和容量的重要参数,通过内阻检测评估电池性能和容量参数,也是科学研究和工业应用的基本原理。电池内阻测量的常用方法一般采用电位差原理。但是,该测量方法对于大型设备的高容量电池存在测量误差大、发热、易损电池等弊端。本文采用基于Cortex-M3核32位微处理微计算机控制和电位差原理的智能内阻测量系统,实现了大容量电池的精确、快速、安全测量和高度智能化的故障诊断功能,具有重要的科学研究意义及实用价值。%All kinds of electrical equipment which use battery as energy sources, are widely used in the industrial production, transportation, military, communications and other fields. And the battery performance is of great importance to normal operation of electrical and electronic equipment. Because the performance and capacity of battery decreases with the increasing number of charge cycles and discharge, the regular maintenance and test of battery performance is the important to guarantee working reliability of electrical equipment. Evaluation battery performance and capacity by testing battery internal resistance, which is the vital parameter for battery performance and capacity, is the basic principles of scientific research and industrial application. Potential difference principle is common method to measure battery internal resistance, but in which the disadvantage is that causing large measurement error, producing heat and damaging battery easily for the large capacity battery of large equipment. In this

  5. Peculiarities of lens and tail regeneration detected in newts after spaceflight aboard Foton M3

    Science.gov (United States)

    Grigoryan, Eleonora N.; Almeida, Eduardo; Poplinskaya, Valentina; Novikova, Julia; Domaratskaya, Elena; Aleinikova, Karina; Souza, Kenneth; Skidmore, Mike; Grigoryan, Eleonora N.

    In September 2007 the joint, 12 day long experiment was carried out aboard Russian satellite Foton M3. The goal of the experiment was to study eye lens, tail and forelimb toe regeneration in adult 16 newts (Pl. waltl.) operated 10 days before taking-off. In spaceflight and synchronous ground control we used video recording, temperature and irradiation control, as well as constant availability of thymidine analog BrdU for its absorption via animals' skin. New techniques allowed us to analyze animals' behavior in hyperand microgravity periods of time, to take proper account of spaceflight factors, and measure accumulated pools of DNA-synthesizing cells in regenerating tissues. All tissue specimens obtained from animals were isolated in the day of landing and then prepared for morphological, immunochemical and molecular investigations. Synchronous control was shifted for two days and reproduced flight conditions except changes of gravity influence. As a result in flown animals as compared with synchronous ground control we found lens regeneration of 0.5-1 stage speeded up and an increased BrdU+ (S-phase) cell number in eye cornea, growth zone, limbus and newly forming lens. These features of regeneration were accompanied by an increase of FGF2 expression in eye growth zone and heat shock protein (HSP90) induction purely in retinal macroglial cells of regenerating eyes. Toe regeneration rate was equal and achieved the stage of accomplished healing of amputation area in both groups - "flown" and control animals. We found no essential differences in tail regeneration rate and tail regenerate sizes in the newts exposed to space and on ground. In both groups tail regeneration reached the stage IV-V when tail length and square were around 4.4 mm and 15.5 mm2, correspondingly. However we did observe remarkable changes of tail regenerate form and some of pigmentation. Computer morphometrical analysis showed that only in ground control animals the evident dorso

  6. Electronic Library: A TERI Experiment.

    Science.gov (United States)

    Kar, Debal C.; Deb, Subrata; Kumar, Satish

    2003-01-01

    Discusses the development of Electronic Library at TERI (The Energy and Resources Institute, New Delhi). Highlights include: hardware and software used; the digital library/Virtual Electronic Library; directory of Internet journals; virtual reference resources; electronic collection/Physical Electronic Library; downloaded online full-length…

  7. Innovative Resources for Education and Public Information: Electronic Services, Data and Information from NASA's Hubble Space Telescope and Other NASA Missions.

    Science.gov (United States)

    Christian, Carol A.

    The Space Telescope Science Institute (STScI), which supports the operation of the Hubble Space Telescope, is actively investigating and supporting innovative and experimental methods for improving science and math education content. The educational resources on the World Wide Web are derived from the latest data, scientific results, and advances…

  8. 1450 m^3 at 10^-9 Pa: One of the KATRIN Challenges

    Energy Technology Data Exchange (ETDEWEB)

    Christian Day; R. Gumbsheimer; W. Herz; J. Wolf; J. Bonn; R. Reid; G.R. Myneni

    2006-11-12

    The KATRIN project is a challenging experiment to measure the mass of the electron neutrino directly with a sensitivity of 0.2 eV. It is a next generation tritium beta-decay experiment scaling up the size and precision of previous experiments by an order of magnitude as well as the intensity of the tritium beta source. Ultrafine spectrometric analysis of the energy distribution of the decay electrons at their very endpoint of 18.57 keV is the key to derive the neutrino mass. This is provided by a high-resolution spectrometer of unique size (10 m in diameter, 22 m in length). To avoid any negative influence from residual gas, the spectrometer vessel is designed to UHV/XHV conditions (an ultimate total pressure of below 10{sup -9} Pa and a wall outgassing rate below 10{sup -13} Pam{sup 3}/scm{sup 2}). The paper shortly describes the experimental idea behind KATRIN. The emphasis will then be given to the pumping concept for how to achieve the target parameters and to the manufacturing of the spectrometer tank. Critical issues will also be discussed (surface treatment, welding, transportation). Finally, a description of the current status and an outlook on the overall KATRIN schedule completes the paper.

  9. An implementation case study. Implementation of the Indian Health Service's Resource and Patient Management System Electronic Health Record in the ambulatory care setting at the Phoenix Indian Medical Center.

    Science.gov (United States)

    Dunnigan, Anthony; John, Karen; Scott, Andrea; Von Bibra, Lynda; Walling, Jeffrey

    2010-01-01

    The Phoenix Indian Medical Center (PIMC) has successfully implemented the Resource and Patient Management System Electronic Health Record (RPMS-EHR) in its Ambulatory Care departments. One-hundred and twenty-six providers use the system for essentially all elements of documentation, ordering, and coding. Implementation of one function at a time, in one clinical area at a time, allowed for focused training and support. Strong departmental leadership and the development of 'super-users' were key elements. Detailed assessments of each clinic prior to implementation were vital, resulting in optimal workstation utilization and a greater understanding of each clinic's unique flow. Each phase saw an increasing reluctance to revert to old paper processes. The success of this implementation has placed pressure on the remainder of the hospital to implement the RPMS-EHR, and has given the informatics team an increased awareness of what resources are required to achieve this result.

  10. 大學圖書館電子資源之需求分析與行銷策略之研究 A Study of Demands Analysis and Marketing Strategy of Electronic Resources in University Library

    Directory of Open Access Journals (Sweden)

    Huang-Yu Liu

    2008-03-01

    Full Text Available 電子資源的出現,使得知識載體有了新的突破,提高了使用者的便利性與即時性。對於圖書館而言,如何使電子資源的使用效益達到最高,必須思考一套有效的行銷策略。電子資源行銷概念應以讀者為導向,尊重讀者的資訊需求,並利用各種宣傳技巧,行銷電子資源,使圖書館能提供更完善的服務。本研究之目的旨在探討讀者的使用需求及電子資源的推廣策略,以獲致最有效益的行銷方式。研究對象以開南大學日間部四學院(商學院、運輸觀光學院、資訊學院、人文社會學院)學生為樣本,佐以缺口分析模型為分析架構,藉以找出個案中讀者/學生對於電子資源使用的真實需求,並進而歸納出提供服務的大學圖書館在其推廣或行銷服務上可有的因應策略。The emergence of electronic resources has made new breakthrough in knowledge carriers because of their ease of use, instant availability, and the characteristic of no time and space constraints. For public libraries to achieve maximum efficiency in its electronic resources, it is necessary to seek the most effective marketing strategies. Therefore, the marketing concept of the electronic resources should be reader oriented, such as respecting and understanding library user’s information needs. Libraries also need to utilize various media and techniques to market the electronic resources, so that more comprehensive services and experiences can be provided to readers. The purpose of this study is to investigate library user’s needs and promotion strategies of electronic resources in order to identify the most effective ways of marketing. This study focuses on the students of the four colleges (College of Business, College of Tourism, College of Information, and College of Humanities and Social Science in Kainan University as subjects in the survey questionnaire. It uses the Gap Analysis

  11. SAP is required for the development of innate phenotype in H2-M3-restricted CD8+ T cells1

    Science.gov (United States)

    Bediako, Yaw; Bian, Yao; Zhang, Hong; Cho, Hoonsik; Stein, Paul L.; Wang, Chyung-Ru

    2012-01-01

    H2-M3-restricted T cells have a pre-activated surface phenotype, rapidly expand and produce cytokines upon stimulation and as such, are classified as innate T cells. Unlike most innate T cells, M3-restricted T cells also express CD8αβ co-receptors and a diverse TCR repertoire: hallmarks of conventional MHC Ia-restricted CD8+ T cells. Although iNKT cells are also innate lymphocytes, they are selected exclusively on hematopoietic cells (HC), while M3-restricted T cells can be selected on either hematopoietic or thymic epithelial cells (TEC). Moreover, their phenotypes differ depending on what cells mediate their selection. Though there is a clear correlation between selection on HC and development of innate phenotype, the underlying mechanism remains unclear. SAP is required for the development of iNKT cells and mediates signals from SLAM receptors that are exclusively expressed on HC. Based on their dual selection pathway, M3-restricted T cells present a unique model for studying the development of innate T cell phenotype. Using both polyclonal and transgenic mouse models we demonstrate that while M3-restricted T cells are capable of developing in the absence of SAP, SAP is required for HC-mediated selection, development of pre-activated phenotype and heightened effector functions of M3-restricted T cells. These findings are significant because they directly demonstrate the need for SAP in HC-mediated acquisition of innate T cell phenotype and suggest that due to their SAP-dependent HC-mediated selection, M3-restricted T cells develop a pre-activated phenotype and an intrinsic ability to proliferate faster upon stimulation, allowing for an important role in the early response to infection. PMID:23041566

  12. 电子商务系统内的人力资源管理模式解析%The analytic model of human resource management in electronic commerce system

    Institute of Scientific and Technical Information of China (English)

    王斌

    2013-01-01

      企业人力资源管理工作在现代电子商务环境下呈现出多方面的电子化新特征,且较之于传统的人力资源管理工作有非常多显著的优势可言,基本上已经成为了企业获取更大成功的基本导向。电子商务系统内的人力资源管理新模式E-HR就是在这样一种背景下应运而生的,E-HR管理模式不仅已经成为了众多企业发展的趋势,而且在实际应用的过程当中也已经给企业带来了非常多的利益。本文正是在此背景之下对电子商务系统内的人力资源管理模式E-HR进行解析,希望能够对其有更深入的理解并更好的应用到实践当中去。%The enterprise human resources management in modern electronic commerce environment presents many new characteristics of the electron,and compared with the traditional human resource management has many significant advantages,basically has become a basic guide for more successful enterprises.E-HR is a new mode of human resource management system emerge as the times require electronic commerce is in such a background,the E-HR management model not only has become the trend of development of many enterprises, but also in the process of practical application also has to the enterprise has brought a lot of benefits. This paper is analyzed under this background to the electronic commerce system within the human resources management mode of E-HR,the application wishes to have a deeper understanding and better on it into practice.

  13. International Conference on Harmonisation; Guidance on M3(R2) Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals; availability. Notice.

    Science.gov (United States)

    2010-01-21

    The Food and Drug Administration (FDA) is announcing the availability of a guidance entitled "M3(R2) Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals.'' The guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The guidance, which is a revision of an existing guidance, discusses the types of nonclinical studies, their scope and duration, and their relation to the conduct of human clinical trials and marketing authorization for pharmaceuticals. The guidance is intended to facilitate the timely conduct of clinical trials and reduce the unnecessary use of animals and other drug development resources.

  14. Positive Perceptions of Access to Online Library Resources Correlates with Quality and Quantity of Scholarly Publications among Finnish Academics. A Review of: Vakkari, Pertti. “Perceived Influence of the Use of Electronic Information Resources on Scholarly Work and Publication Productivity.” Journal of the American Society for Information Science and Technology 59.4 (Feb. 15, 2008: 602-12.

    Directory of Open Access Journals (Sweden)

    Scott Marsalis

    2008-12-01

    Full Text Available Objective – To investigate the relationship between academics’ use of library electronic resources and their opinions regarding how these resources have impacted their work, and to investigate the association between this perceived influence and publication productivity during the previous two years.Design – Two specific questions added to an annual online user-survey questionnaire; additional data mined from surveySetting – Twenty-two Finnish Universities served by FinELib, the Finnish Electronic Library.Subjects – Seven hundred and sixty seven academic staff and full-time doctoral students.Methods – A questionnaire was posted in April 2007 on FinELib’s homepage and advertised on each university library’s mainpage, and focused on respondents’ experience in the previous two years. Participants selected answers either from a list of category choices, or, when measuring perceptions, by rating agreement with statements along a four-point scale. Controlled variables measured were the respondents’ academic position, their discipline, membership in a research group, whether their literature use was discipline-specific or interdisciplinary, and their perception of the availability online of the relevant core literature. The independent variable measured was the scholars’ perception of the impact of the use of electronic library resources on their work. The dependent variable measured was the scholars’ self-reported publications in the two years preceding the survey.Main Results – Participants reported a positive impact on the efficiency of their work, most strongly in areas of ease of access, with lesser impacts in the range of materials available to them and the ease with which they can keep up-to-date in their field. To a lesser extent, the scholars perceived a positive impact on the quality of their work. Upon analysis, the study found that access to online library resources improved scholars’ work by the interconnected

  15. 1750m3高炉煤气除尘改造及TRT发电技术的应用%De-dusting System Improvement and TRT Technology Application on the 1750m3 Blast Furnaces

    Institute of Scientific and Technical Information of China (English)

    曹海刚; 许强

    2012-01-01

    介绍了济钢2座1750m3高炉煤气湿法改干法涂尘及TRT发电的主体设备、主要技术参数及取得的经济效益。%On the two 1750m3 blast furnaces of Jinan Iron and Steel Co., the wet BFG de-ducting system is replaced with the dry de-dusting system and the TRT generation unit is installed. These equipment and their technical data and economic benefits are presented.

  16. Horizontal-Branch Models and the Second-Parameter Effect. IV. The Case of M3 and Palomar 3

    CERN Document Server

    Catelan, M; Rood, R T

    2001-01-01

    We present a detailed analysis of the "second-parameter pair" of globular clusters M3 (NGC 5272) and Palomar 3. Our main results can be summarized as follows: i) The horizontal-branch (HB) morphology of M3 is significantly bluer in its inner regions (observed with the Hubble Space Telescope) than in the cluster outskirts (observed from the ground), i.e., M3 has an internal second parameter. Most plausibly the mass loss on the red giant branch (RGB) has been more efficient in the inner than in the outer regions of the cluster. ii) The dispersion in mass of the Pal 3 HB is found to be very small -- consistent with zero -- and we argue that this is unlikely to be due to a statistical fluctuation. It is this small mass dispersion that leads to the most apparent difference in the HB morphologies of M3 and Pal 3. iii) The relative HB types of M3 and Pal 3, as measured by mean colors or parameters involving the number of blue, variable, and red HB stars, can easily be accounted for by a fairly small difference in ag...

  17. Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation

    Science.gov (United States)

    Yu, Huangfei; Xia, Hongwei; Tang, Qiulin; Xu, Huanji; Wei, Guoqing; Chen, Ying; Dai, Xinyu; Gong, Qiyong; Bi, Feng

    2017-01-01

    Acetylcholine (ACh), known as a neurotransmitter, regulates the functions of numerous fundamental central and peripheral nervous system. Recently, emerging evidences indicate that ACh also plays an important role in tumorigenesis. However, little is known about the role of ACh in gastric cancer. Here, we reported that ACh could be auto-synthesized and released from MKN45 and BGC823 gastric cancer cells. Exogenous ACh promoted cell proliferation in a does-dependent manner. The M3R antagonist 4-DAMP, but not M1R antagonist trihexyphenidyl and M2/4 R antagonist AFDX-116, could reverse the ACh-induced cell proliferation. Moreover, ACh, via M3R, activated the EGFR signaling to induce the phosphorylation of ERK1/2 and AKT, and blocking EGFR pathway by specific inhibitor AG1478 suppressed the ACh induced cell proliferation. Furthermore, the M3R antagonist 4-DAMP and darifenacin could markedly inhibit gastric tumor formation in vivo. 4-DAMP could also significantly enhance the cytotoxic activity of 5-Fu against the MKN45 and BGC823 cells, and induce the expression of apoptosis-related proteins such as Bax and Caspase-3. Together, these findings indicated that the autocrine ACh could act through M3R and the EGFR signaling to promote gastric cancer cells proliferation, targeting M3R or EGFR may provide us a potential therapeutic strategy for gastric cancer treatment. PMID:28102288

  18. Genetic environments of the transferable plasmid-mediated blaCTX-M-3 gene in Serratia marcescens isolates.

    Science.gov (United States)

    Chu, Pei-Yu; Peng, Chien-Fang

    2014-01-01

    In this study, genetic environments of the transferable plasmid-mediated blaCTX-M-3 gene were characterized among 14 isolates of cefotaxime-resistant Serratia marcescens using PCR and BLAST DNA sequence analysis. A total of 3 types of genetic architectures in the regions surrounding this blaCTX-M-3 gene were identified. Type I architecture was characterized by the presence of a complete insertion sequence of tnpA-ISEcp1, identified as interrupting a reverse IS26 sequence in the upstream region of the blaCTX-M-3 gene. A reverse-directional orf477 fragment was located downstream of the blaCTX-M-3 gene, which was in the same direction of the mucA gene. A common region containing the orf513 element was located upstream of the mucA gene. Moreover, a copy of the 3'-CS2 element was located immediately upstream of the orf513 element. A novel complex class 1 integron was characterized by the presence of the dfrA19 gene, which was flanked by two copies of class 1 integrons. This is the first report to describe the dfrA19 gene within a novel complex class 1 integron in S. marcescens isolates from Taiwan. This novel complex class 1 integron structure was located distantly upstream of the blaCTX-M-3 gene.

  19. Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat

    Directory of Open Access Journals (Sweden)

    Yuanhong Xie

    2015-06-01

    Full Text Available To investigate the effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rats, female Wistar rats were fed a high-cholesterol diet (HCD for 28 d to generate hyperlipidemic models. Hyperlipidemic rats were assigned to four groups, which were individually treated with three different dosages of K. marxianus M3+HCD or physiological saline+HCD via oral gavage for 28 d. The total cholesterol (TC, triglycerides (TG, high-density lipoprotein cholesterol (HDL-C, and low-density lipoprotein cholesterol (LDL-C levels in the serum and liver of the rats were measured using commercially available enzyme kits. In addition, the liver morphology was also examined using hematoxylin and eosin staining and optical microscopy. According to our results, the serum and liver TC, TG, LDL-C levels and atherogenic index (AI were significantly decreased in rats orally administered K. marxianus M3 (p <0.01, and the HDL-C levels and anti atherogenic index (AAI were significantly increased (p <0.01 compared to the control group. Moreover, K. marxianus M3 treatment also reduced the build-up of lipid droplets in the liver and exhibited normal hepatocytes, suggesting a protective effect of K. marxianus M3 in hyperlipidemic rats.

  20. Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat.

    Science.gov (United States)

    Xie, Yuanhong; Zhang, Hongxing; Liu, Hui; Xiong, Lixia; Gao, Xiuzhi; Jia, Hui; Lian, Zhengxing; Tong, Nengsheng; Han, Tao

    2015-06-01

    To investigate the effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rats, female Wistar rats were fed a high-cholesterol diet (HCD) for 28 d to generate hyperlipidemic models. Hyperlipidemic rats were assigned to four groups, which were individually treated with three different dosages of K. marxianus M3+HCD or physiological saline+HCD via oral gavage for 28 d. The total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels in the serum and liver of the rats were measured using commercially available enzyme kits. In addition, the liver morphology was also examined using hematoxylin and eosin staining and optical microscopy. According to our results, the serum and liver TC, TG, LDL-C levels and atherogenic index (AI) were significantly decreased in rats orally administered K. marxianus M3 (p <0.01), and the HDL-C levels and anti atherogenic index (AAI) were significantly increased (p <0.01) compared to the control group. Moreover, K. marxianus M3 treatment also reduced the build-up of lipid droplets in the liver and exhibited normal hepatocytes, suggesting a protective effect of K. marxianus M3 in hyperlipidemic rats.

  1. EFFECT OF Nb ON THE MICROSTRUCTURE AND PROPERTIES OF SPRAY FORMED M3 HIGH SPEED STEEL%Nb对喷射成形M3型高速钢组织和性能的影响

    Institute of Scientific and Technical Information of China (English)

    于一鹏; 黄进峰; 崔华; 蔡元华; 张济山

    2012-01-01

    为了利用NbC的高硬度和高热稳定性,并避免其在凝固过程中的过分长大,采用喷射成形快速凝固技术制备了M3型高速钢和以Nb代V的M3型高速钢.利用SEM,EDX和XRD等方法研究了Nb对喷射成形M3型高速钢沉积态组织的影响;利用SRV高温摩擦磨损试验机和三维白光干涉表面形貌仪研究了Nb对喷射成形M3型高速钢摩擦磨损性能的影响.结果表明,用等原子分数的Nb替代V,可大幅增加沉积态中一次MC型碳化物,减少一次M2C型碳化物,同时由于喷射成形高冷速的作用,使得MC碳化物尺寸减小,分布更弥散;这些MC型碳化物的存在是M3型高速钢的抗磨粒磨损性能提高的主要原因,但其对抗氧化性能并无贡献,在高载荷时抗氧化剥落磨损能力增加不明显;Nb对提高M3高速钢回火稳定性也有明显的作用.%Spray forming with a short process chains has been proven to be a powerful tool for the production of high-alloyed materials. Niobium, as a strong former for the carbide, will mainly form primary MC carbides, such as NbC, which can be formed via the reaction between Nb and C atoms at the beginning of solidification, and it can act as the inoculants and refine the cast structure of steel which can mainly form primary MC carbides. M3 high speed steel with or without Nb addition were prepared via spray forming. The effect of Nb on the microstructure of spray formed M3 high speed steel was investigated by SEM, EDX and XRD methods; the friction performances of these two steels were studied by SRV high temperature tribometer and 3D white-light interfering profilometer. The results show that the amount of primary MC carbides can increase sharply while the reduction of the amount of primary M2C due to the substitution of 2% Nb for 1% V (mass fraction) in M3 high speed steel. For the high cooling rate during the spray forming, the primary MC carbides can be refined and dispersed. Large number of primary MC carbides

  2. Lactation resources for clinicians.

    Science.gov (United States)

    Turner-Maffei, Cynthia

    2007-01-01

    Breastfeeding is widely acknowledged as the optimal infant feeding choice. However, many clinicians working in maternal and child health do not receive adequate university preparation to support breastfeeding. Knowledge and skill are most often gained through on-the-job and personal experience. Myriad resources exist to support clinicians in delivering the best quality care to breastfeeding clients. Among the available resources are policies and protocols of professional organizations, governmental, and health advocacy groups. Breastfeeding-focused academic and continuing education programs are identified. Electronic and other resources for breastfeeding information are available for both professional and consumer audiences.

  3. Renewable energy resources

    DEFF Research Database (Denmark)

    Ellabban, Omar S.; Abu-Rub, Haitham A.; Blaabjerg, Frede

    2014-01-01

    Electric energy security is essential, yet the high cost and limited sources of fossil fuels, in addition to the need to reduce greenhouse gasses emission, have made renewable resources attractive in world energy-based economies. The potential for renewable energy resources is enormous because...... they can, in principle, exponentially exceed the world's energy demand; therefore, these types of resources will have a significant share in the future global energy portfolio, much of which is now concentrating on advancing their pool of renewable energy resources. Accordingly, this paper presents how...... renewable energy resources are currently being used, scientific developments to improve their use, their future prospects, and their deployment. Additionally, the paper represents the impact of power electronics and smart grid technologies that can enable the proportionate share of renewable energy...

  4. Merge of terminological resources

    DEFF Research Database (Denmark)

    Henriksen, Lina; Braasch, Anna

    2012-01-01

    In our globalized world, the amount of cross-national communication increases rapidly, which also calls for easy access to multi-lingual high quality terminological resources. Sharing of terminology resources is currently becoming common practice, and efficient strategies for integration...... – or merging – of terminology resources are strongly needed. This paper discusses prerequisites for successful merging with the focus on identification of candidate duplicates of a subject domain found in the resources to be merged, and it describes automatic merging strategies to be applied to such duplicates...... in electronic terminology resources. Further, some perspectives of manual, supplementary assessment methods supporting the automatic procedures are sketched. Our considerations are primarily based on experience gained in the IATE and EuroTermBank projects, as merging was a much discussed issue in both projects....

  5. Expression of the M3 Muscarinic Receptor on Orexin Neurons that Project to the Rostral Ventrolateral Medulla.

    Science.gov (United States)

    Dai, Yu-Wen E; Lee, Yen-Hsien; Chen, Jennifer Y S; Lin, Yen-Kuang; Hwang, Ling-Ling

    2016-05-01

    Activation of central cholinergic receptors causes a pressor response in rats, and the hypothalamus is important for this response. Projections from hypothalamic orexin neurons to the rostral ventrolateral medulla (RVLM) are involved in sympatho-excitation of the cardiovascular system. A small population of orexin neurons is regulated by cholinergic inputs through M3 muscarinic acetylcholine receptor (M3 R). To elucidate whether the M3 R on orexin neurons is involved in cardiosympathetic regulation through the RVLM, we examined the presence of the M3 R on retrograde-labeled RVLM-projecting orexin neurons. The retrograde tracer was unilaterally injected into the RVLM. Within the hypothalamus, retrograde-labeled neurons were located predominantly ipsilateral to the injection side. In the anterior hypothalamus (-1.5 to -2.3 mm to the bregma), retrograde-labeled neurons were densely distributed in the paraventricular nuclei and scattered in the retrochiasmatic area. At -2.3 to -3.5 mm from the bregma, labeled neurons were located in the regions where orexin neurons were situated, that is, the tuberal lateral hypothalamic area, perifornical area, and dorsomedial nuclei. Very few retrograde-labeled neurons were observed in the hypothalamus at -3.5 to -4.5 mm from the bregma. About 19.5% ± 1.6% of RVLM-projecting neurons in the tuberal hypothalamus were orexinergic. The M3 R was present on 18.7% ± 3.0% of RVLM-projecting orexin neurons. Injection of a muscarinic agonist, oxotremorine, in the perifornical area resulted in a pressor response, which was attenuated by a pretreatment of atropine. We conclude that cholinergic inputs to orexin neurons may be involved in cardiosympathetic regulation through the M3 R on the orexin neurons that directly project to the RVLM.

  6. The Wyckoff positional order and polyhedral intergrowth in the M3B2- and M5B3-type boride precipitated in the Ni-based superalloys

    Science.gov (United States)

    Hu, X. B.; Zhu, Y. L.; Sheng, N. C.; Ma, X. L.

    2014-12-01

    Ni-based single superalloys play a crucial role in the hottest parts of jet engines. However, due to the complex geometry and macro-segregation during the solidification process, the cast defect such as stray grains is inevitable. Therefore, the transient liquid phase (TLP) bonding which can join several small single crystalline castings together is gradually believed to be an effective method for improving the yields of production of the complex components. The melting point depressant element B is always added into the interlayer filler material. Consequently, borides including the M3B2 and M5B3 phase usually precipitate during the TLP bonding process. So a comprehensive knowledge of the fine structural characteristics of the borides is very critical for an accurate evaluation of the TLP bonding process. In this work, by means of the aberration-corrected transmission electron microscopy, we show, at an atomic scale, the Wyckoff positional order phenomenon of the metal atoms in the unit cell of M3B2- and M5B3-type boride. Meanwhile, the defect along the (001) plane of the above two types of boride are determined to be the polyhedral intergrowth with complex configurations.

  7. Study and Implementation of Floating-point Operations Based on Cortex-M3 Core%Cortex-M3内核浮点型运算的研究与实现

    Institute of Scientific and Technical Information of China (English)

    梅静静; 王申良

    2011-01-01

    通过分析Cortex-M3内核的结构与浮点型格式,充分利用Cortex-M3内核中的分支预测、单周期乘法、硬件除法等众多功能强大的特性,使用Thumb-2指令集实现了单精度浮点型的加、减、乘、除与比较运算,并给出了加减法运算的流程图和除法运算的源程序.%By analyzing the Cortex-M3 core structure and floating-point format, this paper uses the Thumb-2 instruction set to achieve addition, subtraction, multiplication, division and comparison operations of single-precision floating-point numbers, making full use of such powerful features of Cortex-M3 core as branch prediction, single-cycle multiplication and hardware division. The flow chart of addition and subtraction operations, as well as the source program of division operation, is provided.

  8. TREATMENT OF ABNORMAL TEMPERATURE RISE OF 1 800 m3 BF HEARTH%宣钢1800 m3高炉炉缸温度异常升高的处理

    Institute of Scientific and Technical Information of China (English)

    武建新; 匡祎

    2014-01-01

    This paper is aimed at the abnormal temperature rise of the 1800m3 BF hearth carbon bricks . Through correct diagnosis of furnace body corrosion condition , such measures are taken as increasing tita-nium load into the furnace , enhancing cooling intensity , enhancing tap -hole maintenance to guarantee tap-hole depth , changing field on time while tapping and so on , many hidden safety troubles are elimi-nated , and long-time and smooth operation of the 1 800 m3 BF is guaranteed .%针对2013年1月16日宣钢1800 m3高炉炉缸碳砖温度大幅度异常升高。通过正确诊断炉体侵蚀状况,采取提高入炉钛负荷、提高冷却强度、加强铁口维护保证铁口深度、出铁及时倒场等多项护炉措施,消除了安全隐患,保证了1800 m3高炉炉况长期稳定顺行。

  9. Evaluating the use of a simulated electronic health record and online drug reference in a case study to enhance nursing students' understanding of pharmacologic concepts and resources.

    Science.gov (United States)

    Vana, Kimberly D; Silva, Graciela E

    2014-01-01

    Nursing students should learn to navigate the complexities of the healthcare arena, such as integrating use of electronic health records (EHRs) and online drug references into patient care. Using a simulated EHR in a nursing pharmacology course allowed students to interact with these technologies while learning and applying pharmacologic concepts to a case study. The authors discuss how they created and facilitated such a case study, as well as students' outcomes.

  10. 浅谈高职院校图书馆电子资源的管理和服务%On the Management and Service of the Electronic Resources of Higher Vocational College Library

    Institute of Scientific and Technical Information of China (English)

    邓正芳

    2014-01-01

    Under the background of rapid development of social economy, the computer technology, computer network technology, communication technology, database technology and other information technology, China has entered the information age ahead of time. In higher vocational colleges, the library electronic resources have become an important way for teachers and students to get teaching knowledge and scientific research information, providing reliable, timely and accurate books resources information service for teachers and students. In order to ensure the effective utilization of library electronic resources in higher vocational colleges, scientific and reasonable management is necessary, so as to promote the construction of digital libraries in higher vocational colleges, to achieve better and faster development.%在社会经济的快速发展背景下,我国计算机技术、计算机网络技术、通讯技术以及数据库技术等信息技术的产生,使我国提前进入信息化时代。在高职院校中,图书馆电子资源已经成为老师和学生获取教学知识、科研信息等方面的重要途径,为学校老师和学生提供了可靠、及时、准确的图书资源信息化服务。为了确保高职院校图书馆电子资源的有效利用,需要对其进行科学合理的管理,促进高职院校图书馆数字化建设,使其更好更快地发展。

  11. Power Electronics

    DEFF Research Database (Denmark)

    Iov, Florin; Ciobotaru, Mihai; Blaabjerg, Frede

    2008-01-01

    is to change the electrical power production sources from the conventional, fossil (and short term) based energy sources to renewable energy resources. The other is to use high efficient power electronics in power generation, power transmission/distribution and end-user application. This paper discuss the most...... emerging renewable energy sources, wind energy, which by means of power electronics are changing from being a minor energy source to be acting as an important power source in the energy system. Power electronics is the enabling technology and the presentation will cover the development in wind turbine...... technology from kW to MW, discuss which power electronic solutions are most feasible and used today....

  12. Electronic collection management

    CERN Document Server

    Mcginnis, Suzan D

    2013-01-01

    Build and manage your collection of digital resources with these successful strategies! This comprehensive volume is a practical guide to the art and science of acquiring and organizing electronic resources. The collections discussed here range in size from small college libraries to large research libraries, but all are facing similar problems: shrinking budgets, increasing demands, and rapidly shifting formats. Electronic Collection Management offers new ideas for coping with these issues. Bringing together diverse aspects of collection development, Electronic Collection

  13. Synthesis and characterization of M3V2O8 (M = Ca, Sr and Ba) by a solid-state metathesis approach

    Indian Academy of Sciences (India)

    Purnendu Parhi; V Manivannan; Sandeep Kohli; Patrick Mccurdy

    2008-11-01

    A solid-state metathesis approach initiated by microwave energy has been successfully applied for the synthesis of orthovanadates, M3V2O8 (M = Ca, Sr, and Ba). The structural, vibrational, thermal, optical and chemical properties of synthesized powders are determined by powder X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, magnetic property measurements and diffused reflectance spectra in the UV–VIS range. The direct bandgap of the synthesized materials was found to be 3.55 ± 0.2 eV, 3.75 ± 0.2 eV and 3.57 ± 0.2 eV for Ca3V2O8, Sr3V2O8 and Ba3V2O8, respectively.

  14. 基于高校图书馆电子资源的采访调查与分析——以海南大学图书馆为例%Survey and Analysis Based on the Electronic Resource of University Libraries Taking Hainan University library as an Example

    Institute of Scientific and Technical Information of China (English)

    杨莹

    2011-01-01

    随着信息化时代的到来,高校图书馆的馆藏资源建设模式已经发生了变化,形成了纸质资源与电子资源并存的局面,电子资源以其方便快捷深受读者喜爱,电子资源的采购比例越来越重,如何协调电子资源的采购比例,是图书馆界丞待解决的问题.文章通过对海南大学2006-2010年间的电子资源经费使用情况进行统计、对比和分析,对此问题进行了初步的探讨.%With the arrival of information age, college library collection resources construction mode has changed, and the paper-based resources and electroic resources coexist.With the convenience of electronic resources, the acquisition proportion of electronic resources grows.How to coordinate the acquisition of electronic resource proportion is a problem faced by the libraries.Through the funds statistics, contrast and analysis of electronic resources in hainan university 2006-2010 this article provides a preliminary discussion.

  15. Lead generation using pharmacophore mapping and three-dimensional database searching: application to muscarinic M(3) receptor antagonists.

    Science.gov (United States)

    Marriott, D P; Dougall, I G; Meghani, P; Liu, Y J; Flower, D R

    1999-08-26

    By using a pharmacophore model, a geometrical representation of the features necessary for molecules to show a particular biological activity, it is possible to search databases containing the 3D structures of molecules and identify novel compounds which may possess this activity. We describe our experiences of establishing a working 3D database system and its use in rational drug design. By using muscarinic M(3) receptor antagonists as an example, we show that it is possible to identify potent novel lead compounds using this approach. Pharmacophore generation based on the structures of known M(3) receptor antagonists, 3D database searching, and medium-throughput screening were used to identify candidate compounds. Three compounds were chosen to define the pharmacophore: a lung-selective M(3) antagonist patented by Pfizer and two Astra compounds which show affinity at the M(3) receptor. From these, a pharmacophore model was generated, using the program DISCO, and this was used subsequently to search a UNITY 3D database of proprietary compounds; 172 compounds were found to fit the pharmacophore. These compounds were then screened, and 1-[2-(2-(diethylamino)ethoxy)phenyl]-2-phenylethanone (pA(2) 6.67) was identified as the best hit, with N-[2-(piperidin-1-ylmethyl)cycohexyl]-2-propoxybenz amide (pA(2) 4. 83) and phenylcarbamic acid 2-(morpholin-4-ylmethyl)cyclohexyl ester (pA(2) 5.54) demonstrating lower activity. As well as its potency, 1-[2-(2-(diethylamino)ethoxy)phenyl]-2-phenylethanone is a simple structure with limited similarity to existing M(3) receptor antagonists.

  16. EFFECTIVE ELECTRONIC TUTORIAL

    Directory of Open Access Journals (Sweden)

    Andrei A. Fedoseev

    2014-01-01

    Full Text Available The article analyzes effective electronic tutorials creation and application based on the theory of pedagogy. Herewith the issues of necessary electronic tutorial functional, ways of the educational process organization with the use of information and communication technologies and the logistics of electronic educational resources are touched upon. 

  17. 高顶压技术在莱钢1000m3高炉的应用%Application of High Top Pressure Technology in Laigang 1000 m3 Blast Furnace

    Institute of Scientific and Technical Information of China (English)

    王丰巧

    2015-01-01

    高压操作是强化高炉冶炼的一项重要措施,利于高炉炉况稳定顺行、提高煤气利用率,莱钢1000 m3高炉通过加强原料管理、增加鼓风动能、加强炉前管理等措施提高炉顶压力,取得了显著的经济效益。%High pressure operation is an important measure to strengthen the blast furnace smelting of blast furnace, can be conducive to the stable operation and the exploitation rate of gas.By improving raw material management, increasing the en-ergy of blast furnace, strengthening management measures to strengthen blast furnace top pressure, remarkable economic benefits has been achieved for Laigang 1000 m3 furnace.

  18. Development of Protection System Preventing 60 000 m3 Air Compressor from Stall%60000m3空压机喘振保护系统的研发

    Institute of Scientific and Technical Information of China (English)

    李学波

    2014-01-01

    This article describes the reason and harm of air compressor stall in detail ,and elaborates the principle of the anti-stall control system .A protection system for 60 000 m3 air compressor is set up .By using the function of DCS and PLC ,we can make the control of compressor fast and reliable .This work has important reference value to the other anti-stall control systems .%简述了喘振的原理及危害。详细阐述了防喘振系统的控制原理,并建立了60000 m3空压机的保护系统,利用DCS和PLC的强大功能实现快速可靠的控制,对其他系统的防喘振控制有着重要的参考价值。

  19. M3 version 3.0: Verification and validation; Hydrochemical model of ground water at repository site

    Energy Technology Data Exchange (ETDEWEB)

    Gomez, Javier B. (Dept. of Earth Sciences, Univ. of Zaragoza, Zaragoza (Spain)); Laaksoharju, Marcus (Geopoint AB, Sollentuna (Sweden)); Skaarman, Erik (Abscondo, Bromma (Sweden)); Gurban, Ioana (3D-Terra (Canada))

    2009-01-15

    Hydrochemical evaluation is a complex type of work that is carried out by specialists. The outcome of this work is generally presented as qualitative models and process descriptions of a site. To support and help to quantify the processes in an objective way, a multivariate mathematical tool entitled M3 (Multivariate Mixing and Mass balance calculations) has been constructed. The computer code can be used to trace the origin of the groundwater, and to calculate the mixing proportions and mass balances from groundwater data. The M3 code is a groundwater response model, which means that changes in the groundwater chemistry in terms of sources and sinks are traced in relation to an ideal mixing model. The complexity of the measured groundwater data determines the configuration of the ideal mixing model. Deviations from the ideal mixing model are interpreted as being due to reactions. Assumptions concerning important mineral phases altering the groundwater or uncertainties associated with thermodynamic constants do not affect the modelling because the calculations are solely based on the measured groundwater composition. M3 uses the opposite approach to that of many standard hydrochemical models. In M3, mixing is evaluated and calculated first. The constituents that cannot be described by mixing are described by reactions. The M3 model consists of three steps: the first is a standard principal component analysis, followed by mixing and finally mass balance calculations. The measured groundwater composition can be described in terms of mixing proportions (%), while the sinks and sources of an element associated with reactions are reported in mg/L. This report contains a set of verification and validation exercises with the intention of building confidence in the use of the M3 methodology. At the same time, clear answers are given to questions related to the accuracy and the precision of the results, including the inherent uncertainties and the errors that can be made

  20. M3 version 3.0: Verification and validation; Hydrochemical model of ground water at repository site

    Energy Technology Data Exchange (ETDEWEB)

    Gomez, Javier B. (Dept. of Earth Sciences, Univ. of Zaragoza, Zaragoza (Spain)); Laaksoharju, Marcus (Geopoint AB, Sollentuna (Sweden)); Skaarman, Erik (Abscondo, Bromma (Sweden)); Gurban, Ioana (3D-Terra (Canada))

    2009-01-15

    Hydrochemical evaluation is a complex type of work that is carried out by specialists. The outcome of this work is generally presented as qualitative models and process descriptions of a site. To support and help to quantify the processes in an objective way, a multivariate mathematical tool entitled M3 (Multivariate Mixing and Mass balance calculations) has been constructed. The computer code can be used to trace the origin of the groundwater, and to calculate the mixing proportions and mass balances from groundwater data. The M3 code is a groundwater response model, which means that changes in the groundwater chemistry in terms of sources and sinks are traced in relation to an ideal mixing model. The complexity of the measured groundwater data determines the configuration of the ideal mixing model. Deviations from the ideal mixing model are interpreted as being due to reactions. Assumptions concerning important mineral phases altering the groundwater or uncertainties associated with thermodynamic constants do not affect the modelling because the calculations are solely based on the measured groundwater composition. M3 uses the opposite approach to that of many standard hydrochemical models. In M3, mixing is evaluated and calculated first. The constituents that cannot be described by mixing are described by reactions. The M3 model consists of three steps: the first is a standard principal component analysis, followed by mixing and finally mass balance calculations. The measured groundwater composition can be described in terms of mixing proportions (%), while the sinks and sources of an element associated with reactions are reported in mg/L. This report contains a set of verification and validation exercises with the intention of building confidence in the use of the M3 methodology. At the same time, clear answers are given to questions related to the accuracy and the precision of the results, including the inherent uncertainties and the errors that can be made

  1. Restoration of Bottom Plate Leakage at 80,000 m3 Wiggins Gasholder%8万m3威金斯煤气柜柜底板泄漏修复

    Institute of Scientific and Technical Information of China (English)

    董永涛

    2015-01-01

    8万m3威金斯柜在生产运行中柜底板发生泄漏,采取临时措施封堵后效果不佳,为了避免事态扩大停柜检修,针对柜底板蜂窝状腐蚀,以托补钢板的形式予以加强,消除煤气泄漏的安全隐患.

  2. 基于ARM Cortex-M3的步进电机线性速度控制的实现%The Realization of Linear Speed Control of Stepper Motor Based on ARM Cortex-M3

    Institute of Scientific and Technical Information of China (English)

    罗鑫; 张峰

    2009-01-01

    Conex-M3是ARM公司最新推出的基于ARMy7体系架构的处理核.步进电机已被广泛的应用于速度、位置等控制领域.本文实现了基于Codex-M3内核处理器的步进电机的线性速度控制.针对步进电机控制过程中易出现的失步和过冲现象,提出了一种步进电机加减速控制算法.首先,在Codex-M3内核处理器上移植了μCOS-Ⅱ实时操作系统.在此基础上,利用系统的API接口函数用程序实现了加减速控制算法,并最终实现了对两路步进电机的控制.

  3. [Biological experiments in flights of unmanned space craft Foton-M2 and Foton-M3].

    Science.gov (United States)

    Ilyin, E A

    2013-01-01

    Missions of unmanned spacecraft Foton-M2 (2005) and Foton-M3 (2007) of 16 and 12 days in duration, respectively, provided an opportunity to conduct the Russian/US experiments with snails (Helix lucorum and Helix aspera), newts (Pleurodeles waltli), geckos (Pachydactilus turneri) and microorganisms (Streptomyces lividans 66, E. coli and others). Besides, Foton-M3 carried a Russian experiment with Mongolian gerbils (Meriones unguiculatus). Objectives of the space experiments were to study the micro-g effects on the living systems' behavior, structure and functioning, post-traumatic regeneration of bone and organs, stable inheritance of plasmid pIJ 702, and melanin pigment synthesis by streptomycets. The survey paper presents the major findings of a large team of investigators.

  4. Electrochemical properties of mixed conducting (La,M)(CoFe) oxide perovskites (M=3DSr, Ca, and Ba)

    Energy Technology Data Exchange (ETDEWEB)

    Stevenson, J.W.; Armstrong, T.R.; Bates, J.L. [and others

    1996-04-01

    Electrical properties and oxygen permeation properties of solid mixed-conducting electrolytes (La,M)(CoFe) oxide perovskites (M=3DSr, Ca, and Ba) have been characterized. These materials are potentially useful as passive membranes to separate high purity oxygen from air and as the cathode in a fuel cell. Dilatometric linear expansion measurements were performed as a function of temperature and oxygen partial pressure to evaluate the stability.

  5. The Armys M-1 Abrams, M-2/M-3 Bradley, and M-1126 Stryker: Background and Issues for Congress

    Science.gov (United States)

    2016-04-05

    entered service with the Army in 1980; the M-2/M-3 Bradley Fighting Vehicle in 1981; and the Stryker Combat Vehicle in 2001. Under current Army... Under current Army modernization plans, the Army envisions all three vehicles in service with Active and National Guard forces beyond FY2028...Information from this section, unless otherwise noted, is taken from Jane’s Armour and Artillery, 2011-2012, pp.177- 185, and the author’s personal

  6. Inhalation by design: dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD.

    Science.gov (United States)

    Jones, Lyn H; Baldock, Helen; Bunnage, Mark E; Burrows, Jane; Clarke, Nick; Coghlan, Michele; Entwistle, David; Fairman, David; Feeder, Neil; Fulton, Craig; Hilton, Laura; James, Kim; Jones, Rhys M; Kenyon, Amy S; Marshall, Stuart; Newman, Sandra D; Osborne, Rachel; Patel, Sheena; Selby, Matthew D; Stuart, Emilio F; Trevethick, Michael A; Wright, Karen N; Price, David A

    2011-05-01

    This paper describes the successful design and development of dual pharmacology β-2 agonists-M3 antagonists, for the treatment of chronic obstructive pulmonary disorder using the principles of 'inhalation by design'. A key feature of this work is the combination of balanced potency and pharmacodynamic duration with desirable pharmacokinetic and material properties, whilst keeping synthetic complexity to a minimum. Copyright © 2010 Elsevier Ltd. All rights reserved.

  7. Implications for Damage Recognition during Dpo4-Mediated Mutagenic Bypass of m1G and m3C Lesions

    Energy Technology Data Exchange (ETDEWEB)

    Rechkoblit, Olga; Delaney, James C.; Essigmann, John M.; Patel, Dinshaw J. (MIT); (MSKCC)

    2012-05-08

    DNA is susceptible to alkylation damage by a number of environmental agents that modify the Watson-Crick edge of the bases. Such lesions, if not repaired, may be bypassed by Y-family DNA polymerases. The bypass polymerase Dpo4 is strongly inhibited by 1-methylguanine (m1G) and 3-methylcytosine (m3C), with nucleotide incorporation opposite these lesions being predominantly mutagenic. Further, extension after insertion of both correct and incorrect bases, introduces additional base substitution and deletion errors. Crystal structures of the Dpo4 ternary extension complexes with correct and mismatched 3'-terminal primer bases opposite the lesions reveal that both m1G and m3C remain positioned within the DNA template/primer helix. However, both correct and incorrect pairing partners exhibit pronounced primer terminal nucleotide distortion, being primarily evicted from the DNA helix when opposite m1G or misaligned when pairing with m3C. Our studies provide insights into mechanisms related to hindered and mutagenic bypass of methylated lesions and models associated with damage recognition by repair demethylases.

  8. Drop by drop backscattered signal of a 50 × 50 × 50 m3 volume: A numerical experiment

    Science.gov (United States)

    Gires, A.; Tchiguirinskaia, I.; Schertzer, D.

    2016-09-01

    The goal of this paper is to analyse the influence of individual drop positions on a backscattered radar signal. This is achieved through a numerical experiment: a 3D rain drop field generator is developed and implemented over a volume of 50 × 50 × 50 m3, and then the sum of the electromagnetic waves backscattered by its hydrometeors is computed. Finally the temporal evolution over 1 s is modelled with simplistic assumptions. For the rainfall generator, the liquid water content (LWC) distribution is represented with the help of a multiplicative cascade down to 0.5 m, below which it is considered as homogeneous. Within each 0.5 × 0.5 × 0.5 m3 patch, liquid water is distributed into drops, located randomly uniformly according to a pre-defined drop size distribution (DSD). Such configuration is compared with the one consisting of the same drops being uniformly distributed over the entire 50 × 50 × 50 m3 volume. Due to the fact that the radar wave length is much smaller than the size of a rainfall "patch", it appears that, in agreement with the theory, we retrieve an exponential distribution for potential measures on horizontal reflectivity. Much thinner dispersion is noticed for differential reflectivity. We show that a simple ballistic assumption for drop velocities does not enable the reproduction of radar observations, and turbulence should be taken into account. Finally the sensitivity of these outputs to the various model parameters is quantified.

  9. The surface accessibility of the glycine receptor M2-M3 loop is increased in the channel open state.

    Science.gov (United States)

    Lynch, J W; Han, N L; Haddrill, J; Pierce, K D; Schofield, P R

    2001-04-15

    Mutations in the extracellular M2-M3 loop of the glycine receptor (GlyR) alpha1 subunit have been shown previously to affect channel gating. In this study, the substituted cysteine accessibility method was used to investigate whether a structural rearrangement of the M2-M3 loop accompanies GlyR activation. All residues from R271C to V277C were covalently modified by both positively charged methanethiosulfonate ethyltrimethylammonium (MTSET) and negatively charged methanethiosulfonate ethylsulfonate (MTSES), implying that these residues form an irregular surface loop. The MTSET modification rate of all residues from R271C to K276C was faster in the glycine-bound state than in the unliganded state. MTSES modification of A272C, L274C, and V277C was also faster in the glycine-bound state. These results demonstrate that the surface accessibility of the M2-M3 loop is increased as the channel transitions from the closed to the open state, implying that either the loop itself or an overlying domain moves during channel activation.

  10. Power Electronics

    DEFF Research Database (Denmark)

    Iov, Florin; Ciobotaru, Mihai; Blaabjerg, Frede

    2008-01-01

    energy at the end-user should also be set up. Deregulation of energy has in the past lowered the investment in larger power plants, which means the need for new electrical power sources will be high in the near future. Two major technologies will play important roles to solve the future problems. One...... is to change the electrical power production sources from the conventional, fossil (and short term) based energy sources to renewable energy resources. The other is to use high efficient power electronics in power generation, power transmission/distribution and end-user application. This paper discuss the most...... emerging renewable energy sources, wind energy, which by means of power electronics are changing from being a minor energy source to be acting as an important power source in the energy system. Power electronics is the enabling technology and the presentation will cover the development in wind turbine...

  11. Study of time-lapse processing for dynamic hydrologic conditions. [electronic satellite image analysis console for Earth Resources Technology Satellites imagery

    Science.gov (United States)

    Serebreny, S. M.; Evans, W. E.; Wiegman, E. J.

    1974-01-01

    The usefulness of dynamic display techniques in exploiting the repetitive nature of ERTS imagery was investigated. A specially designed Electronic Satellite Image Analysis Console (ESIAC) was developed and employed to process data for seven ERTS principal investigators studying dynamic hydrological conditions for diverse applications. These applications include measurement of snowfield extent and sediment plumes from estuary discharge, Playa Lake inventory, and monitoring of phreatophyte and other vegetation changes. The ESIAC provides facilities for storing registered image sequences in a magnetic video disc memory for subsequent recall, enhancement, and animated display in monochrome or color. The most unique feature of the system is the capability to time lapse the imagery and analytic displays of the imagery. Data products included quantitative measurements of distances and areas, binary thematic maps based on monospectral or multispectral decisions, radiance profiles, and movie loops. Applications of animation for uses other than creating time-lapse sequences are identified. Input to the ESIAC can be either digital or via photographic transparencies.

  12. Resource Manual

    Science.gov (United States)

    Human Development Institute, 2008

    2008-01-01

    This manual was designed primarily for use by individuals with developmental disabilities and related conditions. The main focus of this manual is to provide easy-to-read information concerning available resources, and to provide immediate contact information for the purpose of applying for resources and/or locating additional information. The…

  13. Rethinking Resourcing.

    Science.gov (United States)

    Norris, Donald M.; Olson, Mark A.

    2003-01-01

    This adaptation of an excerpt from a book, "The Business Value Web: Resourcing Business Processes and Solutions in Higher Education," addresses ways to look at college business processes systematically, take fresh approaches to resourcing, and create real value for stakeholders. (EV)

  14. The central dynamics of M3, M13, and M92: stringent limits on the masses of intermediate-mass black holes

    Science.gov (United States)

    Kamann, S.; Wisotzki, L.; Roth, M. M.; Gerssen, J.; Husser, T.-O.; Sandin, C.; Weilbacher, P.

    2014-06-01

    We used the PMAS integral field spectrograph to obtain large sets of radial velocities in the central regions of three northern Galactic globular clusters: M3, M13, and M92. By applying the novel technique of crowded field 3D spectroscopy, we measured radial velocities for about 80 stars within the central ~10″ of each cluster. These are by far the largest spectroscopic datasets obtained in the innermost parts of these clusters up to now. To obtain kinematical data across the whole extent of the clusters, we complement our data with measurements available in the literature. We combine our velocity measurements with surface brightness profiles to analyse the internal dynamics of each cluster using spherical Jeans models, and investigate whether our data provide evidence for an intermediate-mass black hole in any of the clusters. The surface brightness profiles reveal that all three clusters are consistent with a core profile, although shallow cusps cannot be excluded. We find that spherical Jeans models with a constant mass-to-light ratio provide a good overall representation of the kinematical data. A massive black hole is required in none of the three clusters to explain the observed kinematics. Our 1σ (3σ) upper limits are 5300 M⊙ (12 000 M⊙) for M3, 8600 M⊙ (13 000 M⊙) for M13, and 980 M⊙ (2700 M⊙) for M92. A puzzling circumstance is the existence of several potential high velocity stars in M3 and M13, as their presence can account for the majority of the discrepancies that we find in our mass limits compared to M92. Based on observations collected at the Centro Astronómico Hispano-Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC).Appendices are available in electronic form at http://www.aanda.orgTables D.1 to D.6 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc

  15. Design of Instrument Lathe Control System Based on CORTEX-M3 Technology%基于CORTEX-M3技术的仪表车床控制系统设计

    Institute of Scientific and Technical Information of China (English)

    李香泉; 刘浪; 洪耀球

    2012-01-01

    采用了基于CORTEX-M3核的STM32F103VCT6 ARM芯片作为核心,实现4轴步进电机控制功能,同时系统还实现了与基于MODBUS RTU协议的文本显示或工业触摸屏的通信功能,以及获取相关输入信号和控制继电器功能.

  16. 8×104m3威金斯转炉煤气柜密封膜破损修复处理%Renovation the Broken Sealing Membrane of 8×104m3 Wiggins Converter Gas Tank

    Institute of Scientific and Technical Information of China (English)

    王树奇; 张军; 刘芳荣

    2013-01-01

    文章介绍了8× 104m3威金斯转炉煤气柜发生密封膜破损泄漏事故,分析了密封膜损坏的原因分析.希望通过此次事故,能提高运行人员和点检人员对八万转炉煤气柜的高度认识和密切关注,在以后的工作当中,避免此类事情的发生.

  17. Assessment of use of library resources on research activities of ...

    African Journals Online (AJOL)

    Open Access DOWNLOAD FULL TEXT ... Library resources use contribute immensely to the research output of agricultural scientists and ... electronics Library resources such as electronic journals, e-books, scholarly databases, ... researchers to have access to a wide range of high quality electronic information resources.

  18. Genetic toxicology: web resources.

    Science.gov (United States)

    Young, Robert R

    2002-04-25

    Genetic toxicology is the scientific discipline dealing with the effects of chemical, physical and biological agents on the heredity of living organisms. The Internet offers a wide range of online digital resources for the field of Genetic Toxicology. The history of genetic toxicology and electronic data collections are reviewed. Web-based resources at US National Library of Medicine (NLM), including MEDLINE, PUBMED, Gateway, Entrez, and TOXNET, are discussed. Search strategies and Medical Subject Headings (MeSH) are reviewed in the context of genetic toxicology. The TOXNET group of databases are discussed with emphasis on those databases with genetic toxicology content including GENE-TOX, TOXLINE, Hazardous Substances Data Bank, Integrated Risk Information System, and Chemical Carcinogenesis Research Information System. Location of chemical information including chemical structure and linkage to health and regulatory information using CHEMIDPLUS at NLM and other databases is reviewed. Various government agencies have active genetic toxicology research programs or use genetic toxicology data to assist fulfilling the agency's mission. Online resources at the US Food and Drug Administration (FDA), the US Environmental Protection Agency (EPA), the National Institutes of Environmental Health Sciences, and the National Toxicology Program (NTP) are outlined. Much of the genetic toxicology for pharmaceuticals, industrial chemicals and pesticides that is performed in the world is regulatory-driven. Regulatory web resources are presented for the laws mandating testing, guidelines on study design, Good Laboratory Practice (GLP) regulations, and requirements for electronic data collection and reporting. The Internet provides a range of other supporting resources to the field of genetic toxicology. The web links for key professional societies and journals in genetic toxicology are listed. Distance education, educational media resources, and job placement services are also

  19. 地方高校的电子文献资源建设——以南京晓庄学院为例%Construction of Electronic Literature Resources of Local University Library —— A Case Study ofNanjing Xiaozhuang University

    Institute of Scientific and Technical Information of China (English)

    王雯

    2012-01-01

    以南京晓庄学院图书馆为蓝本,从电子资源的文献价值入手,阐明了编制电子资源的采访标准和评价指标的意义,指出在当前网络环境下,地方高校加强电子文献资源建设的重要性和发展方向。%This paper is on the original version ofNanjing Xiaozhuang University library, from the literature value of electron- ic resource, expounds the meaning of compiling electronic resources acquisition standard and evaluation index, points out under current network environment, the importance of local university library strengthen electronic litera-ture resources construction and development direction.

  20. The Strategies for the Construction of the Electronic Journal Resources in Higher Vocational College Library in the Network Environment%网络环境下高职院校图书馆电子期刊资源建设策略

    Institute of Scientific and Technical Information of China (English)

    黄妙琼

    2015-01-01

    This paper expounds some main principles of the construction of the network electronic journal resources in higher vocational college library in the network environment, introduces several types of the network electronic journal resources, and probes into some strategies for the construction of electronic journal resources in higher vocational college library.%阐述了高职院校图书馆网络电子期刊资源建设的主要原则,介绍了网络电子期刊资源的几种类型, 探讨了高职院校图书馆电子期刊资源建设的策略.

  1. 区域性高校数字图书馆联盟电子资源建设研究--以湖南省高校数字图书馆为例%Study on the Electronic Resources Construction of Regional University Digital Library Alliance---Taking Hunan Academic Digital Library (HNADL)as an Example

    Institute of Scientific and Technical Information of China (English)

    唐婷

    2015-01-01

    介绍了湖南省高校数字图书馆电子资源建设情况,阐述了各联盟成员馆电子资源建设现状,探讨了湖南省高校数字图书馆电子资源建设存在的问题,并提出了相应的对策及建议。%ABSTRACT:This paper introduces the situation of the electronic resources construction of HNADL, expounds the current status of the electronic resources construction of each number library, probes into the problems existing in the electronic resources construction of HNADL,and puts forward some corresponding countermeasures and suggestions.

  2. Telecommunications--Electronic Mail.

    Science.gov (United States)

    Kelly, Luke E.; Zuckerman, B. Michael

    1989-01-01

    This article identifies resources needed in order for physical education, recreation, and dance professionals to use computer-based telecommunications; discusses electronic mail; and explains how telecommunications can enhance communication in the field, both within and across professions. (IAH)

  3. Rethinking resources

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, W.L. [Univ. of Texas, Austin, TX (United States)

    1994-09-01

    We class energy and mineral resources as finite because we are reasonably certain that they do not form at a rate remotely approaching man`s rate of use. We have certain environments of the earth that have limits in carrying capacity, and we presume that the global environment does as well. These facts and presumptions, coupled with anxieties over growth in population and consumption, have posed pictures of impending catastrophe from Malthus through the Club of Rome and currently, among certain advocates of what is called sustainable development. To avoid future calamity, command and control management of resource use is urged by many. But, quite simply, such management would presume a wisdom that historical experience suggests does not exist. As a recent example, consider natural gas resources. A decade and a half ago, the resource base of natural gas in the United States was judged to be near exhaustion. Estimates of remaining resources by governmental agencies, academicians, and several major energy companies indicated the ultimate resource would be at about 100 tcf today, with essential depletion by the end of the century. Such was the near universal wisdom that compelled Congress to enact legislation to outright prohibit certain use of natural gas. Today, after nearly eight years of gas supply in excess of demand and with entirely new appreciation of the impact of technology, estimates of the remaining gas resource by industry, government, and others are an order of magnitude greater than those made just 15 yr ago, and the same government that then sought to husband a resource presumed to be near depletion now aggressively promotes its use and consumption. Limits to resources and limits to environmental carrying capacity do indeed exist, but we have yet to define those limits and the paths thereto.

  4. lOT Data Acquisition Substation for forestry ecology monitor Based on Cortex- M3%Cortex—M3的生态物联网数据采集分站设计

    Institute of Scientific and Technical Information of China (English)

    李骏慧; 陶华; 俞哲伟; 宋军

    2011-01-01

    The IOT(Internet of things)data acquisition substation for forestry ecology monitor is proposed, which employs the Cortex- M3 processor as the CPU. Digital temperature humidity sensor, smoke sensor, C()2 sensor and digital luminance sensor are employed to acquire the environment information which is related with forestry ecology. Then the sensors data are collected by LM3S811 and ID of substation is added to data packet. Further more, LM3SSll transmits the data packet to servers using RF module.%以Cortex—M3处理器LM3S811为核心,设计了面向森林生态监测的物联网数据采集终端分站系统。通过单总线数字式温湿度传感器、烟雾传感器、CO2传感器和环境光亮度传感器分别采集温度、湿度、可燃性颗粒物、CO2含量和光照等与林木生态相关的环境信息和林场防火的相关信息。由LM3S81l处理器处理并添加分站ID和校验码后,采用无线模块传送给服务器。

  5. 100 m3/min往复式空压机长周期安全稳定运行研究%Study on Long, Safe and Stable Operation of 100 m3/min Reciprocating Air Compressor

    Institute of Scientific and Technical Information of China (English)

    陈山

    2015-01-01

    介绍了安徽晋煤中能化工股份有限公司100 m3/min往复式空压机的工况,针对影响机组长周期稳定、安全运行的问题,采取了优化设备结构和工艺结构的措施,优化结果表明:年创造经济效益16.28万元,实现了节能降耗的目的。%This paper introduces the working conditions of 100 m3/min reciprocating air compressor of Anhui Jinmei Zhongneng Chemical Co. , Ltd. To solve the problem affecting long, safe and stable operation of the unit, the author optimizes the structures of the equipment and the process. The opti-mization results show that it has gained 162 800 RMB yuan/a economic benefit and achieved its energy-saving and consumption-reducing purpose.

  6. 石家庄陕鼓2×40000m^3/h空分设备设计优化%Optimized design of Shijiazhuang Shaanxi Blower Group 2 ×40000m^3/h air separation plant

    Institute of Scientific and Technical Information of China (English)

    张岑; 卢子学

    2012-01-01

    At design stage of Shijiazhuang Shaanxi Blower Group 2 ×40000m^3/h air separation plants, it found unreasonable design in the nitrogen compression and supply system, air compressor vent silencer, and connection mode for feeding boosted air to plate-fin type heat exchanger, as well as the factors impairing stable and safe operation of the product continuous supply and air separation plant. Here, the optimization measures taken for the unreasonable factors are described, which puts a sound basis for stable run of the air separation plant.%在石家庄陕鼓2×40000m^3/h空分设备设计阶段,发现氮气压缩和供应系统、空压机放空消声器以及增压空气进板翅式换热器的连接方式设计不舍理,存在影响产品连续供应和空分设备稳定、安全运行的因素。介绍对这些不合理因素所采取的优化措施,为空分设备建成后稳定运行奠定基础。

  7. 3500m3/h绞吸挖泥船甲板机舱振动分析与优化%Analysis and Optimization of Deck Cabin Vibration in 3 500 m3/h Cutter Suction Dredger

    Institute of Scientific and Technical Information of China (English)

    王炜

    2015-01-01

    针对3500 m3/h绞吸式挖泥船的甲板机舱异常振动问题,建立机舱结构有限元模型,进行振动模态分析,发现甲板下支柱与柴油机工作频率耦合引起的共振是导致甲板机舱异常振动的主要原因,进行甲板机舱结构和立柱位置的优化,检测表明,优化后的结构有效避开了共振频率,振动速度峰值和加速度大幅下降,优化效果良好。%In view of abnormal vibration on deck engine room of 3 500 m3/h cutter suction dredger, the FE structural model of the engine room is established.Via the analysis of mode of vibration, resonance coupling of working frequency of the diesel en-gine with the pillar under deck is the primary cause for abnormal vibration of deck engine room.So the location of pillars is rede-signed to avoid the resonant frequency.The test results verify that the peaks of vibration acceleration and velocity are sharply de-creased;the effects of optimization are satisfactory.

  8. Logic control of molecular sieve purification system of 65000m3· h-1 air separation plant%65000m3·h-1空分设备分子筛纯化系统逻辑控制

    Institute of Scientific and Technical Information of China (English)

    朱玉芹

    2012-01-01

    The structure and technical process of molecular sieve purification system of 65000m3/ an air separation plant of Hebi coal and electeicity 600 ktpa methanol project are briefed, automatic valve closing / opening logical control of molecular sieve purification system, automatic / manual operation sequence control program,implementation of the sequence control program and optimized reform of the sequence control configuration program of the molecular sieve absorber in accordance with site operation conditions are described.%简介鹤壁煤电股份有限公司化工分公司空分厂65000m3·h-1空分设备分子筛纯化系统结构和工艺流程,介绍分子筛纯化系统阀门自动开关控制逻辑、顺控程序自动/手动运行、顺控程序执行过程,以及根据现场生产运行实际情况,对分子筛吸附器顺控组态程序进行的优化改进.

  9. Design of Low-cost LCD Touch Screen Based on Cortex-M3%基于Cortex-M3的低成本液晶触摸屏设计

    Institute of Scientific and Technical Information of China (English)

    张勇; 邹卫军

    2014-01-01

    选用NXP公司内置LCD控制器的Cortex-M3处理器LPC1788作为主控,设计了一种低成本的液晶触摸屏。介绍了四线电阻式触摸屏与LPC1788的接口设计,移植emWin图形界面库为GUI提供支持。实际运用证明,低成本液晶触摸屏运行稳定,界面设计便捷。%This paper provides a Iow-cost LCD Touch Screen design which use LPC1788 as the processor.LPC1788 which is de-signed by NXP,is a SoC based on Cortex-M3 CPU and contains a buiId-in LCD controI er,and introduces the interface of 4-wire resistive touch pad with LPC1788.In addition,transpIant the graphicaI interface Iibrary emWin to provide best support for the design of GUI.The practicaI appIication shows this screen works stabIy and makes the interface design convenient.

  10. 基于ARM Cortex M3内核TFT触摸屏无线遥控设计%On Wireless Remote Control System Design Based on the ARM Cortex M3 core TFT Touch Screen

    Institute of Scientific and Technical Information of China (English)

    李金赐; 梁九兴

    2012-01-01

    The designing is based on Bluetooth communication through the ARM Contex M3 core microprocessor STM32F103VET6 and TEF color LCD touch screen to design a touch-screen remote control.This kind of remote control,through touching the controls displayed on the TFT color LCD of the host computer,triggers variety of control signals and then wireless Bluetooth module sends control signals.%本设计是建立在蓝牙通信下通过ARM Cortex M3内核的微处理器STM32F103VET6与TFT彩色液晶触摸屏来设计一种触摸屏遥控器。该遥控器通过触摸上位机TFT彩色液晶触摸屏上显示的各个控件来触发各种控制信号;无线蓝牙模块发送各种控制信号。

  11. Design and Realization of GUI Based on ARM Cortex-M3%基于ARM Cortex-M3的图形用户界面设计和实现

    Institute of Scientific and Technical Information of China (English)

    韩定

    2015-01-01

    采用基于Cortex-M3内核的LPC1788为主控芯片和320(RGB)*480 pixels的带触摸点阵液晶屏,应用emWin图形库设计了一款简单易用的小型人机交互界面,并提供大容量的图片存储空间和可扩展字库存储空间,便于用户使用,可以广泛应用于家庭自动化和工业控制领域。%The ARM Cortex-M3 kernel processor LPC1788 and 320*480 pixels LCD with touch is used to design a small Graphical User Interface. EmWin is a kind of open source software, which is used to GUI embedded system. It can be widely used in home automation and industrial control.

  12. 年产5000m3意杨LVL主材及设备量的计算与配置%Calculation and Configuration of Main Material and Equipment Quantity for Annual 5000m3 Populus LVL

    Institute of Scientific and Technical Information of China (English)

    蒋瞻

    2012-01-01

      LVL has become the fastest kind of wooden composite material product in the current woodworking industry. The configuration of materials and equipment of an enterprise located in Northern Jiangsu that manufactures 5000 m 3 Populus LVL annually is introduced, with emphasis placed on relevant design calculation and configuration of such main materials as veneer and adhesive and such main equipment as presses, with the aim to provide reference for China’s small and medium-sized plywood manufacturing enterprises in term of design of the materials and equipment for manufacturing Populus LVL products.%  LVL已成为当今木材加工行业发展速度最快的一种木质复合材料产品。介绍了苏北一家年产5000m3意杨LVL企业的加工材料与设备配置情况,着重对单板、胶黏剂主材及压机等主要设备进行了相关的设计计算与配置,为我国制造胶合板的中小型企业做好意杨LVL产品的主材及其设备的设计工作提供参考。

  13. DISCUSSION ABOUT HEAT BALANCE CALCULATION AND ENERGY SAVING FOR 2500 m3 BLAST FURNACE%承钢2500 m3高炉热平衡测算与节能探讨

    Institute of Scientific and Technical Information of China (English)

    王秀英

    2014-01-01

    以承钢3座2 500 m3高炉为研究对象,用第一总热平衡测试法进行了高炉热平衡测算.结果表明:承钢2 500 m3高炉近年来节能主要是降低了冷却软熔带带走热量约0.29 GJ/tFe,减少煤气带走热量约0.12 GJ/tFe,降低瓦斯灰带走热量约0.04 GJ/tFe.从测算结果可以看出,因高炉工艺优化吨铁耗风量降低后,收入项中热风带入的热量减少约0.4 GJ/tFe,碳素氧化带入的热量减少约0.12 GJ/tFe.介绍了承钢高炉近年采用的节能技术及应用效果,根据热平衡测算结果和目前的前沿节能技术,提出了承钢高炉进一步降低能耗的措施.

  14. Scale-up of industrial biodiesel production to 40 m(3) using a liquid lipase formulation.

    Science.gov (United States)

    Price, Jason; Nordblad, Mathias; Martel, Hannah H; Chrabas, Brent; Wang, Huali; Nielsen, Per Munk; Woodley, John M

    2016-08-01

    In this work, we demonstrate the scale-up from an 80 L fed-batch scale to 40 m(3) along with the design of a 4 m(3) continuous process for enzymatic biodiesel production catalyzed by NS-40116 (a liquid formulation of a modified Thermomyces lanuginosus lipase). Based on the analysis of actual pilot plant data for the transesterification of used cooking oil and brown grease, we propose a method applying first order integral analysis to fed-batch data based on either the bound glycerol or free fatty acid content in the oil. This method greatly simplifies the modeling process and gives an indication of the effect of mixing at the various scales (80 L to 40 m(3) ) along with the prediction of the residence time needed to reach a desired conversion in a CSTR. Suitable process metrics reflecting commercial performance such as the reaction time, enzyme efficiency, and reactor productivity were evaluated for both the fed-batch and CSTR cases. Given similar operating conditions, the CSTR operation on average, has a reaction time which is 1.3 times greater than the fed-batch operation. We also showed how the process metrics can be used to quickly estimate the selling price of the enzyme. Assuming a biodiesel selling price of 0.6 USD/kg and a one-time use of the enzyme (0.1% (w/woil ) enzyme dosage); the enzyme can then be sold for 30 USD/kg which ensures that that the enzyme cost is not more than 5% of the biodiesel revenue. Biotechnol. Bioeng. 2016;113: 1719-1728. © 2016 Wiley Periodicals, Inc.

  15. Syntheses, crystal structure and magnetic properties of Rm+nCo5m+3nB2n

    Institute of Scientific and Technical Information of China (English)

    梁敬魁; 陈怡; 陈小龙

    2001-01-01

    The phase relations at the 600℃ and 700℃ isothermal sections of the ternary systems R-Co-B for R= Nd, Pr and R = Sm, Gd respectively were summarized in this paper. For Rm+ n Co5m+3n B2n, two new types ofcompounds R3Co13B2(R=Pr, Nd, Sm, Gd, Dy, Ho, Er, Y) (m=2, n=1) andR5Co19B6(R=Pr, Nd) (m=2,n = 3 ) were synthesized by utilizing the principle of structural combination. Their crystalstructures and easymagnetization direction were determined by X-ray powder diffraction, and structures were refined by the Rietveldmethod. The Curie temperature Tc, saturation magnetization M8 and anisotropic field HA of the new compounds weremeasured using a vibrating-sample magnetometer, an extraction sample magnetometer and M(H) - H curves of samplesin different magnetization directions respectively. The Tc and Ms of Rm + n Co5 m + 3 n B2n increase with increasing values of mat a given n value. HA increases with an increase in n when m is kept invariable. The effects of the substitution of Ni for Co on the magnetic properties of Nd13 Co15- x Nix B2 were also investigated. It was found that TsR decreased monotonously as the concentration of Ni increased, and at x = 3 the easy magnetization direction becomes axial at room temperature. The relations between crystal structure and magnetic properties of Rm + nCo5m+ 3nB2n and the possible routes of synthesizing permanent magnetic materials are also discussed.

  16. Successful management of pulmonary hemorrhage and aspergillosis in a patient with acute myeloid leukemia (AML-M3

    Directory of Open Access Journals (Sweden)

    Hulya Gunbatar

    2015-01-01

    Full Text Available A 35-year-old man presented with a one month history of gingival bleeding. He was diagnosed with Acute Myeloid Leukemia (AML-M3. During treatment he developed alveolar hemorrhage for which he was treated with a steroid. After the steroid treatment he developed a nodule, a cavitary lesion and atelectasia in the left lung. He was treated with voriconazole. After therapy with voriconazole his lesion significantly decreased. This case illustrates the efficacy and safety of antifungal therapy with voriconazole for aspergillosis complicated by AML.

  17. Successful management of pulmonary hemorrhage and aspergillosis in a patient with acute myeloid leukemia (AML-M3).

    Science.gov (United States)

    Gunbatar, Hulya; Demir, Cengiz; Kara, Erdal; Esen, Ramazan; Sertogullarindan, Bunyamin; Asker, Selvi

    2015-01-01

    A 35-year-old man presented with a one month history of gingival bleeding. He was diagnosed with Acute Myeloid Leukemia (AML-M3). During treatment he developed alveolar hemorrhage for which he was treated with a steroid. After the steroid treatment he developed a nodule, a cavitary lesion and atelectasia in the left lung. He was treated with voriconazole. After therapy with voriconazole his lesion significantly decreased. This case illustrates the efficacy and safety of antifungal therapy with voriconazole for aspergillosis complicated by AML.

  18. Arthritis - resources

    Science.gov (United States)

    Resources - arthritis ... The following organizations provide more information on arthritis : American Academy of Orthopaedic Surgeons -- orthoinfo.aaos.org/menus/arthritis.cfm Arthritis Foundation -- www.arthritis.org Centers for Disease Control and Prevention -- www. ...

  19. Diabetes - resources

    Science.gov (United States)

    Resources - diabetes ... The following sites provide further information on diabetes: American Diabetes Association -- www.diabetes.org Juvenile Diabetes Research Foundation International -- www.jdrf.org National Center for Chronic Disease Prevention and Health Promotion -- ...

  20. Seaweed resources

    Digital Repository Service at National Institute of Oceanography (India)

    Deshmukhe, G.V.; Dhargalkar, V.K.; Untawale, A.G.

    The chapter summarizes our present knowledge of the seaweed resources of the Indian Ocean region with regard to the phytogeographical distribution, composition, biomass, utilization, cultivation, conservation and management. The voluminous data...

  1. Mineral resources

    Digital Repository Service at National Institute of Oceanography (India)

    Valsangkar, A.B.

    (placers), biogenous (ooze, limestone) or chemogenous (phosphorites and polymetallic nodules) type. In recent years, hydrothermal deposits, cobalt crust and methane gas hydrates are considered as frontier resources. Their distribution depends upon proximity...

  2. Depression - resources

    Science.gov (United States)

    Resources - depression ... Depression is a medical condition. If you think you may be depressed, see a health care provider. ... following organizations are good sources of information on depression : American Psychological Association -- www.apa.org/topics/depress/ ...

  3. Land Resources

    Science.gov (United States)

    Young, Anthony

    1998-08-01

    Unless action is taken, the developing world will face recurrent problems of food security and conflict. This volume provides a summary and perspective of the field of land resources and suggests improvements needed to conserve resources for future generations. Coverage provides an authoritative review of the resources of soils, water, climate, forests and pastures on which agriculture depends. It assesses the interactions between land resources and wider aspects of development, including population and poverty. It provides a strong critique of current methods of assessing land degradation and placing an economic value on land. It should be read by all involved in rural development, including scientists, economists, geographers, sociologists, planners, and students of development studies.

  4. Hemophilia - resources

    Science.gov (United States)

    Resources - hemophilia ... The following organizations provide further information on hemophilia : Centers for Disease Control and Prevention -- www.cdc.gov/ncbddd/hemophilia/index.html National Heart, Lung, and Blood Institute -- www.nhlbi.nih.gov/ ...

  5. Forest Resources

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-06-01

    Forest biomass is an abundant biomass feedstock that complements the conventional forest use of wood for paper and wood materials. It may be utilized for bioenergy production, such as heat and electricity, as well as for biofuels and a variety of bioproducts, such as industrial chemicals, textiles, and other renewable materials. The resources within the 2016 Billion-Ton Report include primary forest resources, which are taken directly from timberland-only forests, removed from the land, and taken to the roadside.

  6. Water resources utilization and eco-environmental safety in Northwest China%中国西北水资源利用及生态环境安全

    Institute of Scientific and Technical Information of China (English)

    张济世; 徐进祥; 张永秋

    2006-01-01

    Northwest China includes Xinjiang Ugyur Autonomous Region, Qinghai Province, Gansu Province, Ningxia Hui Autonomous Region and Shaanxi Province, covering 308× 104 km2. It is located in the warm-temperate zone and the climate is arid or semi-arid. Precipitation is very scarce but evaporation is extremely high. The climate is dry, the water resources are deficient, the eco-environment is fragile, and the distribution of water resources is uneven. In this region, precipitation is the only input, and evaporation is the only output in the inland rivers, and precipitation, surface water and groundwater change with each other for many times, which benefits the storage and utilization of water resources.The average precipitation in this region is 232 mm, the total precipitation amount is 7003 × 108 m3/a,the surface water resources are 1891 × 108 m3/a, the total natural groundwater resources are 1150× 108 m3/a,the total available water resources are 438 × 108 m3/a, and the total water resources are 1996× 108 m3/a and per capita water resources are 2278 m3/a. The water resources of the whole area are 5.94× 104 m3/(a.km2),being only one-fifth of the mean value in China. Now, the available water resources are 876×108 m3/a,among which groundwater is proximate 130× 108 m3/a.

  7. The Horizontal Branch in the UV Colour Magnitude Diagrams. II. The case of M3, M13 and M79

    CERN Document Server

    Dalessandro, Emanuele; Ferraro, Francesco R; Mucciarelli, Alessio; Cassisi, Santi

    2012-01-01

    We present a detailed comparison between far-UV/optical colour Magnitude Diagrams obtained with high-resolution Hubble Space Telescope data and suitable theoretical models for three Galactic Globular Clusters: M3, M13 and M79. These systems represents a classical example of clusters in the intermediate metallicity regime that, even sharing similar metal content and age, show remarkably different Horizontal Branch morphologies. As a consequence, the observed differences in the colour distributions of Horizontal Branch stars cannot be interpreted in terms of either first (metallicity) or a second parameter such as age. We investigate here the possible role of variations of initial Helium abundance (Y). Thanks to the use of a proper setup of far-UV filters, we are able to put strong constraints on the maximum Y (Y_{max}) values compatible with the data. We find differences Delta Y_{max} ~ 0.02-0.04 between the clusters with M13 showing the largest value (Y_{max} ~ 0.30) and M3 the smallest (Y_{max} ~ 0.27). In g...

  8. Model for Presenting Resources in Scholar's Portal

    Science.gov (United States)

    Feeney, Mary; Newby, Jill

    2005-01-01

    Presenting electronic resources to users through a federated search engine introduces unique opportunities and challenges to libraries. This article reports on the decision-making tools and processes used for selecting collections of electronic resources by a project team at the University of Arizona (UA) Libraries for the Association of Research…

  9. 安钢10万m3威金斯气柜利用效率探讨与应用%Efficiency Analysis and Application of Anyang Iron and Steel 100 000 m3 Wiggins Gasholder

    Institute of Scientific and Technical Information of China (English)

    于海顺; 王志峰; 王祥凯; 张文杰; 赵卫兵

    2015-01-01

    As to the operating situation of Augang 100 000 Wiggins gas holder, this paper analyzes the efficiency factors of Wiggins gesholder, and puts forward improving weasuers, including establishing a liaision mechauism, adjusting part programs of micro oxygen analzer before gasholder in gasholder control system to improve the gas-holder efficiency.%针对安钢10万m3威金斯气柜运行现状,对影响威金斯气柜利用效率的因素进行了探讨,并提出了建立联络机制、调整气柜控制系统中气柜进口前微氧分析仪的部分程序等改进措施。采取有效措施后提高了气柜的利用效率。

  10. Electronics and electronic systems

    CERN Document Server

    Olsen, George H

    1987-01-01

    Electronics and Electronic Systems explores the significant developments in the field of electronics and electronic devices. This book is organized into three parts encompassing 11 chapters that discuss the fundamental circuit theory and the principles of analog and digital electronics. This book deals first with the passive components of electronic systems, such as resistors, capacitors, and inductors. These topics are followed by a discussion on the analysis of electronic circuits, which involves three ways, namely, the actual circuit, graphical techniques, and rule of thumb. The remaining p

  11. 高铝渣对济钢3200m3高炉冶炼的影响%Influence of High Al2O3 Slag on Operation of 3 200 m3 BF in Jinan Steel

    Institute of Scientific and Technical Information of China (English)

    王军

    2015-01-01

    To the characteristics of high Al2O3 slag with higher viscosity, poor liquidity, and poor desulphurization ability, by adjusting the thermal system and distributing system, the Mg/Al ratio in the slag is controlled lager than 0.6 by increasing the MgO content in sintering, the MgO content in the slag is made between 8%-11%, the overall operation of 3 200 m3 BF in Jinan Steel can fit smelting requirement with high Al2O3 slag. Under the condition of slag ratio increase by 43 kg/t, the silicon in the pig iron was decreased, the desulphurization ability of the slag was strengthened and third grade iron was eliminated basically.%针对高铝渣特有的黏度高、流动性差、脱硫能力差的特点,济钢3 200 m3高炉通过调整热制度和布料制度,在烧结时提高MgO含量,控制渣中镁铝比>0.6,使渣中MgO含量在8%~11%,高炉的整体操作炉型适应了高铝渣的冶炼要求.在渣铁比升高43 kg/t的条件下,高炉生铁含硅降低,炉渣脱硫能力增强,基本杜绝了三类铁.

  12. New Technology Adopted and Operation Practice in No.3 3 200 m3 BF in Laiwu Steel%莱钢3#3200 m3高炉采用的新技术及生产实践

    Institute of Scientific and Technical Information of China (English)

    贾利军; 孟淑敏; 王冰

    2016-01-01

    In the paper, a series of new process and technology adopted in newly built No.3 3 200 m3 BF in laiwu steel are introduced, such as comprehensive technology of blast furnace longevity,multi nozzle type and fixed hopper of PW bell-less top, technology of axial cyclone deduster plus automatically discharging ash system, environmental INBA slag granulation technology, the dehumidified blast technology of BF and so on. The blast furnace was started up smoothly and reached the design product, in addition, all kinds of operation experience was happened, for example, intensified smelting, high coal ratio, large ore batch, limited production, wind-off without plan. The results were verified that every system ran normally and had better technical and economic index.%介绍了莱钢3#3200 m3高炉采用的长寿综合技术、多流嘴式料流分配器+固定料罐的PW无料钟炉顶设备、轴流旋风除尘器+吸排罐车自动卸灰系统、环保型INBA法渣处理技术、高炉脱湿鼓风技术等设计特点,高炉顺利开炉达产,历经强化冶炼、高煤比、大矿批、限产、无计划休风等不同操作实践,炉况顺行良好,各工艺系统运行正常,取得了良好的技术经济指标。

  13. Portable and Smart Ultrasonic Fluid Level Meter Based on ARM Cortex- M3%基于ARM Cortex - M3便携式智能超声波液位计

    Institute of Scientific and Technical Information of China (English)

    张根宝; 李秀平; 庞苏娟

    2012-01-01

    为了准确测量环境恶劣工业生产中的液位以保证生产效率,通过研究超声波测距工作原理,采用新型高性能、低功耗和低成本的ARM - Cortex M3内核微控制器,结合超声波技术、红外传输与DS1820温度补偿修正设计了一款便携式智能超声波液位计.其采用的先进微处理器以及无线传输的方式,简化了硬件电路,优化了软件编程.研究表明:该液位计设计提高了液位测量精度、实时性、灵活性与快速性.%To measure fluid level in poor industrial production conditions accurately for ensuring production efficiency,a portable intelligent correction ultrasonic fluid level meter was designed by studying the working principle of ultrasonic distance measurement. New high-performance, low power and low-cost ARM-Cortex M3 microcontroller core, combined with ultrasonic technology, infrared transmission and DS1820 temperature compensation were used in the level meter. The use of advanced microprocessor and wireless transmission, simplified hardware and optimized software programming. Studies show that the design of this fluid level gauge improved accuracy,timeliness,flexibility and rapidity of the level measurement.

  14. 莱钢3号3200 m3高炉设计创新与实践%Design innovation and practice of No. 3200 m3 BF in Laigang

    Institute of Scientific and Technical Information of China (English)

    王冰; 孟淑敏; 贾利军

    2016-01-01

    莱钢3号3200m3高炉设计采用了串罐无料钟炉顶、软水密闭循环冷却、炉体全覆盖冷却壁、铜冷却壁、 UCAR热压小块炭砖、改进型顶燃式热风炉、环保型INBA渣处理、轴流式旋风除尘器、环保平坦化出铁场、全干法布袋除尘、高富氧喷煤等一系列先进实用、成熟可靠、清洁环保、高效长寿的新技术设备,为实现高炉“高效、优质、低耗、长寿、环保”的目标打下了坚实的基础。%A series of advanced and suitable , mature and reliable , clean and environmentally friendly, high efficiency and long campaign techniques were adopted in the design of No. 3 3200m3 BF in Laiwu Steel, such as BLT, closed loop soft water cooling, complete coverage of furnace body cooling stave, copper cooling staves, UCAR hot pressing small pieces of carbon brick, improved top combus-tion hot blast stove, environmental friendly INBA slag treatment, axial cyclone deduster, green flat cast house, completely dry method bag deduster, high oxygen enrichment PCI, all the new technolo-gies mentioned above has laid a solid foundation for blast the target of high efficiency, high quality, low consumption, long campaign and clean environmental protection.

  15. Hearth Erosion Situation Analysis for the 1 750 m3 Blast Furnace in Jinan Steel%济钢1750 m3高炉炉缸侵蚀情况分析

    Institute of Scientific and Technical Information of China (English)

    张小伟; 张熙玮

    2015-01-01

    通过对生产条件及炉缸结构相同的济钢1#、3#1750 m3高炉炉缸侵蚀情况进行调查,发现1#高炉炉缸呈浅锅底—象脚状侵蚀,扒炉实测表明,炉缸、炉底交接处侵蚀最为严重,炭砖残存厚度最薄处仅为300 mm;3#高炉铁口附近炭砖出现不同程度裂纹,侵蚀严重处炭砖残存厚度600 mm。建议考虑炭砖的微孔度,使用高可靠性热电偶,降低炉底冷却水流量,增加炉缸冷却水流量等,以提高高炉寿命。%The hearth erosion of Jinan Steel’s No.1 and No.3 1 750 m3 BF have been investigated, although they have the same production conditions and hearth structure. It is found that the No.1 blast furnace hearth pale pot is like the foot-shaped erosion, griddle test shows junction of hearth and bottom are the most serious erosion position, the remaining thickness of the thinnest carbon brick is only 300 mm. The carbon bricks near the iron mouth of the No.3 BF have cracked to some extent, the remaining carbon brick thickness of severe erosion is 600 mm. To improve and prolong the life of the blast furnace, it is suggested that to apply the porous carbon bricks and high reliability thermocouples, reduce the cooling water flow for bottom, increase the cooling water flow of the hearth etc.

  16. Design of on-broad diagnose terminal with real-time warning based on CORTEX-M3%基于CORTEX-M3的实时车载诊断预警系统的设计

    Institute of Scientific and Technical Information of China (English)

    陈鲤文; 邹复民

    2013-01-01

    The design of ODB-II standard framework is based on embedded real-time operation and it can be realized on Cortex-M3 CPU core with uc/os II operating system. We have successful read real-time OBD-II data of vehicles from PC monitor and gather accident codes and sensor data through CAN bus, which can be used to evaluate the health of the automobiles, preventive against trouble, deduce the cost of driving and improve the driving safety. The advantage to the device is taking full account of all sorts of vehicle buses and put forward a kind of resolved scheme about remote on-boarded diagnosis in complicated vehicle circumstance.%基于嵌入式实时操作系统的OBD-Ⅱ诊断协议框架,以Cortex-M3为内核,采用uc/os Ⅱ操作系统实现了ISO15765协议,成功通过CAN总线读取了车辆的OBD-Ⅱ系统数据,通过上位机监控窗口,能实时检查汽车故障码与汽车传感器数据.可在此基础上评价汽车健康状况,并可对故障及早预防,降低行车成本,提供行车安全性;本设计充分考虑中国汽车市场主流总线发展的情况,提供了在复杂的车载环境下远程车载诊断设备的解决方案.

  17. Multilingual digital resources with Bulgarian language

    Directory of Open Access Journals (Sweden)

    Ludmila Dimitrova

    2015-11-01

    Full Text Available Multilingual digital resources with Bulgarian language The paper presents in brief Bulgarian language resources as a part of multilingual digital resources developed in the frame of some international projects, among them parallel annotated and aligned corpora, comparable corpora, morpho-syntactic specifications for corpora annotation and dictionaries encoding, lexicons, lexical databases, and electronic dictionaries.

  18. THE INFLUENCE OF THE INGOT MOLD COOLING ON THE STRUCTURE OF SILUMINA CASTINGS AK15M3 AT VERTICAL CENTRIFUGAL CASTING

    Directory of Open Access Journals (Sweden)

    V. Yu. Stecenko

    2013-01-01

    Full Text Available Influence of ways of the mold cooling on structure of castings with diameter of 135 mm from AK15M3 silumin at vertical centrifugal casting is investigated. It is established that for production of castings with diameter 135 mm from AK15M3 silumin with high mechanical and tribotechnical properties it is necessary to apply a shaped mould with water-spray cooling at expense of cooler of 0,42 m3/h.

  19. Potential recoverable natural gas resources in China

    Institute of Scientific and Technical Information of China (English)

    Liu Chenglin; Zhu Jie; Che Changbo; Liu Guangdi

    2008-01-01

    Natural gas resources in China are abundant. The undiscovered recoverable natural gas resources in China are estimated to be 19.27×1012 m3. Natural gas is mainly distributed in the middle and west China and offshore areas of China. The Tarim Basin, Sichuan Basin, Ordos Basin, East China Sea Basin, Tsaidam Basin, Yinggehai Basin, and Qiongdongnan Basin are the main gas-beating basins. The natural gas resources are not distributed evenly and are under-explored in China. The deeper horizons in east China, foreland basins and craton paleo-uplifts in the middle and west China, and the offshore basins are the main exploration areas in the future.

  20. Effects of the A-site cation number on the properties of Ln5/8M3/8MnO 3 manganites

    Science.gov (United States)

    Collado, J. A.; García-Muñoz, J. L.; Aranda, M. A. G.

    2010-05-01

    The properties of manganites can be tuned by changing the doping level x in Ln1-xM xMnO 3. A second mechanism allows tuning of magnetic and electronic properties, for fixed x values, by varying the average A-cation radius, . Moreover, for fixed x and values, the changes in the A-cation size variance, σ2, also modify the ferromagnetic and metal-insulator transition temperatures. Here, we investigate the influence of the number of A-site cations on Ln5/8M3/8MnO 3 manganites, where x, and σ2 values are kept constant, and in the absence of phase separation phenomena. We have found that the number of cation species at the A site ( N A) has a strong influence on the width of the ferromagnetic and metal-insulator transitions, and a small influence on the average transition temperature. This behavior is opposite to that observed for increasing values of the variance σ2 in manganites, with the same x and values, where average transition temperatures are strongly reduced.

  1. STEP electronic system design

    Science.gov (United States)

    Couch, R. H.; Johnson, J. W.

    1984-01-01

    The STEP electronic system design is discussed. The purpose of the design is outlined. The electronic system design is summarized and it is found that: an effective conceptual system design is developed; the design represents a unique set of capabilities; makes efficient use of available orbiter resources; the system capabilities exceed identified potential experiment needs.

  2. [Morphological changes in gastric wall of mongolian gerbils following the 12-day orbital flight aboard Foton-M3].

    Science.gov (United States)

    Atiashkin, D A; Bykov, É G

    2012-01-01

    Gastric wall of Meriones unguiculatus is distinguished by species-specific properties arising from the peculiar proportion of interstitium, muscle and epithelial tissues. Exposure to the factors of the 12-d Foton-M3 flight led to microfocal lesions of the mucous coat, dystrophic developments in the acid glands, dissociation of the mucous barrier function and deterioration of its biosynthetic function. Modifications of the tinctorial properties of the interstitium reticulum in every stomach layer progressed concurrently with reductions in prismatic epithelium height, as well as in mucous and muscular layer thickness. It is assumed that existence in the low gravity aboard the Biosat stimulated involutory processes in the gastric wall. Animals of the ground synchronous control conducted in the flight equipment mockup (Kontur-L) exhibited though similar yet less pronounced changes.

  3. Elements in the canine distemper virus M 3' UTR contribute to control of replication efficiency and virulence.

    Directory of Open Access Journals (Sweden)

    Danielle E Anderson

    Full Text Available Canine distemper virus (CDV is a negative-sense, single-stranded RNA virus within the genus Morbillivirus and the family Paramyxoviridae. The Morbillivirus genome is composed of six transcriptional units that are separated by untranslated regions (UTRs, which are relatively uniform in length, with the exception of the UTR between the matrix (M and fusion (F genes. This UTR is at least three times longer and in the case of CDV also highly variable. Exchange of the M-F region between different CDV strains did not affect virulence or disease phenotype, demonstrating that this region is functionally interchangeable. Viruses carrying the deletions in the M 3' UTR replicated more efficiently, which correlated with a reduction of virulence, suggesting that overall length as well as specific sequence motifs distributed throughout the region contribute to virulence.

  4. Conversión de diagramas de procesos en diagramas de casos de usos usando AToM3

    Directory of Open Access Journals (Sweden)

    CARLOS M. ZAPATA J.

    2005-01-01

    Full Text Available Toda pieza de software se origina en el modelo verbal, con el cual se pueden definir los diferentes modelos conceptuales que acerquen el problema a una solución. Las herramientas convencionales para la construcción de los modelos conceptuales no toman en consideración las diferentes reglas de consistencia que se pueden presentar entre los diferentes modelos. En este artículo se emplea el AToM3 como herramienta para la definición de los meta-modelos del diagrama de procesos y el diagrama de casos de uso, con el fin de reexpresar el primero para obtener algunos elementos básicos del segundo.

  5. Anomalous Hall hysteresis in T m3F e5O12/Pt with strain-induced perpendicular magnetic anisotropy

    Science.gov (United States)

    Tang, Chi; Sellappan, Pathikumar; Liu, Yawen; Xu, Yadong; Garay, Javier E.; Shi, Jing

    2016-10-01

    We demonstrate robust interface strain-induced perpendicular magnetic anisotropy in atomically flat ferrimagnetic insulator T m3F e5O12 (TIG) films grown with pulsed laser deposition on a substituted G d3G a5O12 substrate which maximizes the tensile strain at the interface. In bilayers consisting of Pt and TIG, we observe large squared Hall hysteresis loops over a wide range of thicknesses of Pt at room temperature. When a thin Cu layer is inserted between Pt and TIG, the Hall hysteresis magnitude decays but stays finite as the thickness of Cu increases up to 5 nm. However, if the Cu layer is placed atop Pt instead, the Hall hysteresis magnitude is consistently larger than when the Cu layer with the same thickness is inserted in between for all Cu thicknesses. These results suggest that both the proximity-induced ferromagnetism and spin current contribute to the anomalous Hall effect.

  6. Photometric and spectroscopic observations of the F3+M3 eclipsing binary T-Lyr0-08070

    CERN Document Server

    Cakirli, O; Sipahi, E

    2012-01-01

    The multi-color photometric and spectroscopic observations of the newly discovered eclipsing binary T-Lyr0-08070 were obtained. The resultant light and radial velocities were analysed and the absolute parameters of the components were determined. The system is composed of an F3 and an M3 main-sequence stars. Masses and radii were estimated to be 1.37$\\pm$0.23 M$_{\\odot}$ and 1.60$\\pm$0.09 R$_{\\odot}$ for the primary and 0.32$\\pm$0.04 M$_{\\odot}$ and 0.86$\\pm$0.06R$_{\\odot}$ for the secondary star. The less massive secondary component has a radius at least two times larger with respect to its mass. Using the BVJHK magnitudes of the system we estimated an interstellar reddening of 0.22 mag and a distance to the system as 479$\\pm$36 pc.

  7. Moment Tensors and their Uncertainties for M3 Earthquakes in the Geysers, California, from Waveform Modeling and First Motions

    Science.gov (United States)

    Guilhem, A.; Dreger, D. S.; Hutchings, L. J.; Johnson, L.

    2012-12-01

    We investigate moment tensor solutions and their uncertainties for magnitude (M) ~3 earthquakes located in the northwest Geysers geothermal field, California. We are exploiting an unusual opportunity where data for M~3 events have been recorded by three different networks and have moment tensor solutions calculated by three different methods. We solve for both deviatoric and full moment tensor solutions. The data sets include local short-period instruments (4.5 Hz) of the 30 stations of the Lawrence Berkeley National Laboratory (LBNL), with which we obtain waveform inversion solutions at relatively high frequencies (i.e., up to 2.5 Hz), and regionally distributed broadband stations operated by the Berkeley Seismological Laboratory (BSL), with which are used to provide waveform inversion solutions with data filtered at longer periods (i.e., > 10 sec). We also utilize the LBNL data to obtain moment tensor solutions by fitting the P-wave first motions. The USGS, LBNL, and BSL obtain different event locations, utilize different velocity models, and analyze different frequency bands and wave types (i.e., body waves for LBNL method and primarily surface waves for the BSL analysis). Preliminary results indicate that the BSL and LBNL waveform modeling analyses give similar results in terms of nodal plane characteristics, moment magnitude, and moment tensor decomposition. Analysis of the P-wave first motions recorded by LBNL stations can illuminate complexities in the source processes when compared to waveform moment tensor solutions. We discuss uncertainties in the source inversions that use broadband and/or short-period waveform modeling, and in the source inversions from first motions only. We also combine the different datasets and compare their individual importance as they can help illustrate the complex source processes happening in the Geysers. This study introduces the possibility to interpret the seismic sources as complex processes in which both shear and tensile

  8. 高校图书馆外文电子资源的建设与利用研究——以安徽建筑大学图书馆为例%Study on the Construction and Utilization of Foreign Electronic Resources in University Library ——A Case Study of the Library of AUA

    Institute of Scientific and Technical Information of China (English)

    黄静

    2015-01-01

    This paper makes an investigation and statistical analysis on the current construction ans utilization of foreign electronic resources of the library of AUA from the aspects of the quantities, funds as well as utilization rate of foreign database, discusses some factors influencing the construction and utilization of foreign electronic resources, and probes into the countermeasures for strengthening the construction of foreign electronic resources and improving the utilization rate of foreign electronic resources.%从外文数据库的数量、经费和利用率等方面,对安徽建筑大学图书馆外文电子资源建设与利用现状进行了调查研究与统计分析,论述了影响外文电子资源建设与利用的因素,探讨了加强外文电子资源建设、提高外文数据库利用率的对策.

  9. Interactive Technologies in Electronic Educational Resources

    Science.gov (United States)

    Anisimova, Tatyana Ivanovna; Krasnova, Lyubov Alekseevna

    2015-01-01

    Modern professional education in the transition to a tiered system of specialists training is focused not on the transfer of ready knowledge but on teaching to find this knowledge and to apply them in situations close to the professional conditions. The educational process, relying on use of interactive methods of teaching, which is organized with…

  10. Helix 8 and the i3 loop of the muscarinic M3 receptor are crucial sites for its regulation by the Gβ5-RGS7 complex.

    Science.gov (United States)

    Karpinsky-Semper, Darla; Tayou, Junior; Levay, Konstantin; Schuchardt, Brett J; Bhat, Vikas; Volmar, Claude-Henry; Farooq, Amjad; Slepak, Vladlen Z

    2015-02-01

    The muscarinic M3 receptor (M3R) is a Gq-coupled receptor and is known to interact with many intracellular regulatory proteins. One of these molecules is Gβ5-RGS7, the permanently associated heterodimer of G protein β-subunit Gβ5 and RGS7, a regulator of G protein signaling. Gβ5-RGS7 can attenuate M3R-stimulated release of Ca(2+) from intracellular stores or enhance the influx of Ca(2+) across the plasma membrane. Here we show that deletion of amino acids 304-345 from the central portion of the i3 loop renders M3R insensitive to regulation by Gβ5-RGS7. In addition to the i3 loop, interaction of M3R with Gβ5-RGS7 requires helix 8. According to circular dichroism spectroscopy, the peptide corresponding to amino acids 548-567 in the C-terminus of M3R assumes an α-helical conformation. Substitution of Thr553 and Leu558 with Pro residues disrupts this α-helix and abolished binding to Gβ5-RGS7. Introduction of the double Pro substitution into full-length M3R (M3R(TP/LP)) prevents trafficking of the receptor to the cell surface. Using atropine or other antagonists as pharmacologic chaperones, we were able to increase the level of surface expression of the TP/LP mutant to levels comparable to that of wild-type M3R. However, M3R-stimulated calcium signaling is still severely compromised. These results show that the interaction of M3R with Gβ5-RGS7 requires helix 8 and the central portion of the i3 loop.

  11. Design of Dynamic Electrocardiogram Based on ARM Cortex-M3%基于ARM Cortex-M3的动态心电图机设计

    Institute of Scientific and Technical Information of China (English)

    谢建华; 刘海波; 刘瑞芳

    2012-01-01

    In order to enrich the product categories and function of the dynamic electrocardiogram,a new type of dynamic electrocardiogram product based on ARM (Advanced RISC Machines) Cortex-M3 is developed. The system hardware consists a processor minimum system,bioelectricity amplification module, storage module,LCD(Liquid Crstal Display) and touch screen module,high speed USB interface and the power module. For the system software, the platform was build based on CooCox CoOS embedded realtime operating system, the file system and USB middleware. The man-machine interface is realized by transplanting uC/GUI. The experiment results showed that the system could be used to control ECG signal collection,great capacity data storage and high-speed upload. The graphical user interface and real time waveform display are the innovative points.%针对目前动态心电图机产品种类和功能单一的现状,研制了基于ARM(Advanced RISC Machines) Cortex-M3的新型动态心电图机.硬件主要由处理器最小系统、生物电放大模块、存储模块、LCD (Liquid Cgstal Display)和触摸屏模块、高速USB接口和电源模块构成.软件开发基于CooCox CoOS嵌入式实时操作系统,同时使用了文件系统和USB等中间件.移植uC/GUI实现人机接口设计.测试结果表明,该系统不但实现了心电信号采集、大容量数据存储和高速上传的功能,而且创新性地增加了图形用户界面和实时波形显示功能.

  12. Car Design of WiFi Internet of Things Based on SCM Cortex-M3%基于Cortex-M3单片机的WiFi物联网小车的设计

    Institute of Scientific and Technical Information of China (English)

    汤莉莉; 黄伟; 王春波; 方规

    2014-01-01

    使用无线互联网WiFi技术,采集小车上传感器的相关数据,并做相应的处理和控制,实现远程控制和监控功能。研究的范围包括Cortex-M3内核的LPC1768单片机软件的编程,单片机温度、速度、视屏的采集处理和传输,电脑软件的编程, Windows环境下的视屏处理、模拟速度表盘和模拟温度计的设计与实现以及TCP/IP通信实现等。方案采用自下而上的模块化编程方法,对温度和速度测试模块进行了模拟测试,对WiFi通信机制做了大量的数据分析,实现用电脑软件通过无线WiFi控制小车的运动、采集相关信息并显示等功能。%The purpose of this design is to use wireless Internet WiFi technology to collect the related data of car sensor,perform appropriate process and control,and ultimately realize remote control and monitoring functions.The study covers the SCM LPC1768 soft-ware programming of Cortex-M3 core,and the temperature,speed,screen capture processing and transmission of SCM,together with the design and implementation of screen processing,analog dial of speed,analog thermometer and TCP/IP communication under Windows environments.The scheme uses a bottom-up modular programming method to implement the simulation and test for temperature and speed testing module,perform much of data analysis of WiFi communication mechanism,and finally use computer software to achieve the control the car′s movement,collect and display relevant information through wireless WiFi.

  13. Design of mine DC electrical prospecting instrument based on ARM Cortex-M3 core%基于ARM Cortex-M3内核矿井直流电法仪的研制

    Institute of Scientific and Technical Information of China (English)

    宁殿艳; 张仲礼; 王继矿; 汪凯斌; 李超

    2011-01-01

    DC electrical prospecting instrument has played an important role in preventing mine water disaster, but the traditional DC electrical prospecting instrument has some disadvantages such as high power consumption, small storage capacity, hard operation and difficulty to carry, for it is mostly developed utilizing MCS -51 microcontroller. These restrict the application of DC electrical prospecting instrument to a certain extent. This article begins with the working principle of mine DC electrical, improves the traditional DC electrical prospecting instrument utilizing STM32 microcomputer based on Cortex - M3 core and 24 - bit Σ - A ADC component, and redesigns the hardware and software of mine DC eldetrieal instrument. The improved instrument has the advantage of high accuracy, low cost, low power consumption, large storage capacity, convenient communication and friendly man-machine interface compared with traditional DC electrical prospecting instrument.%直流电法仪在预防煤矿水害中发挥重要作用,但传统直流电法仪的核心芯片多采用51系列单片机,具有功耗大、存储容量小、操作不方便,难以携带等缺点,在一定程度上制约了直流电法仪的应用.文中从矿井直流电法仪的工作原理出发,采用基于ARM Cortex-M3内核的STM32处理器和基于Σ-Δ技术的24位高分辨率ADC器件对传统矿井直流电法仪进行了升级、改造,重新设计了硬件电路和软件程序.与传统矿井直流电法仪相比,新设计的直流电法仪具有精度高、成本低、功耗小、存储容量大、通讯方便和人机界面友好等优点.

  14. 电场对金属串配合物M3(dpa)4Cl2(M=Co,Rh,Ir;dpa=dipyridylamide)结构的影响%Effects of Electric Field on the Structures of Metal String Complexes M3(dpa)4Cl2 (M=Co, Rh, Ir; dpa=dipyridylamide)

    Institute of Scientific and Technical Information of China (English)

    黄燕; 黄晓; 许旋

    2013-01-01

      应用密度泛函理论 PBE0方法研究具有分子导线潜在应用的金属串配合物 M3(dpa)4Cl2(1: M=Co,2:M=Rh,3: M=Ir; dpa=dipyridylamide)在电场作用下的几何和电子结构.结果表明:配合物基态均是二重态.1和2的M36+金属链形成三中心三电子σ键,3中M36+形成三中心四电子σ键且存在弱的δ键.随金属原子周期数增大其M―M键增强、LUMO与HOMO能隙减小、金属原子的反铁磁耦合减弱以至消失且自旋密度向配体的离域增强.在Cl4→Cl5电场作用下,低电势端的M3-Cl5键缩短,高电势端的M2―Cl4键增长, M―M平均键长略为缩短, M―M键增强,有利于分子线的电子传递;分子能量降低,偶极矩线性增大.低电势端Cl5的负电荷向高电势端Cl4转移,且3中金属原子的正电荷由高电势端向低电势端的转移较明显,自旋电子由低电势端向高电势端金属原子移动,但桥联配体dpa-与M和Cl所在的分子轴间没有电荷转移.电场使LUMO与HOMO能隙减小,有利于分子的电子输运.随金属原子周期数增大,电场作用下M―M平均键长变化减小, LUMO、HOMO的能级交错现象减少.%As potential molecular wire species, the geometrical and electronic structures of metal string complexes M3(dpa)4Cl2 (1: M=Co, 2: M=Rh, 3: M=Ir; dpa=dipyridylamide) were investigated theoretical y using density functional theory with the PBE0 functional by considering the interaction of an external electric field along the M36+ linear metal chain. The results show that the ground states of the complexes are al doublets. There is a 3-center-3-electron σ bond delocalized over the M36+ chain for 1 and 2, while there is a 3-center-4-electron σ bond and a weak δ bond among the Ir36+ chain in 3. Moving down the column of Co, Rh, and Ir elements in the periodic table, the complexes with the corresponding metals showed some regular trends, such as stronger M - M bonds, smal er LUMO-HOMO gaps, weaker anti

  15. 77 FR 76598 - Notice of Receipt of Petition for Decision That Nonconforming 2006-2010 BMW M3 Passenger Cars Are...

    Science.gov (United States)

    2012-12-28

    ... vehicles that are not already so equipped; and (b) replacement of any non U.S.- model air bags, air bag...-2010 BMW M3 Passenger Cars Are Eligible for Importation AGENCY: National Highway Traffic Safety...-2010 BMW M3 passenger cars that were not originally manufactured to comply with all applicable Federal...

  16. Time-Resolved Hot Electron Transport in Electronic Devices

    Science.gov (United States)

    1988-12-01

    wavevector in the barrier). For the heavy holes tunneling from QWI to QW2 the k’s are k2 = (2mb(VI-E) A2" k3 = (2m 3E/ hZJ . For the electrons tunneling from...Laser-Exci, td bem~onductors,’ Prog. Quantum Electron. 9, 3 (1984). 9 G. D. Sanders and Yia-Chung Chang, "Theory of Photoabsorption in Modulation-Doped

  17. 某10万m3钢储罐罐体变形的修复措施%The Rectification Methodof 100,000 m3 Steel Oil Storage Tank Wall Deformation

    Institute of Scientific and Technical Information of China (English)

    应付钊; 丁伟

    2013-01-01

    The differential settlement of tank foundation or low quality tank erection will cause wall deformation of steel oil storage tank, the low quality tank erection will have greater effect on the lifting of floating roof than the differential settlement of tank foundation. In the paper, the reason causing wall deformation and rectification method were introduced, some questions that need considered during steel oil storage tank erection and high pressure filling method of cavity which is between tank bottom plate and tank foundation were pointed. Finally, some referable conclusions are obtained.%地基不均匀沉降和安装不当均会引起钢储罐罐体变形,安装不当引起的罐体变形比罐基础不均匀沉降造成的罐体变形对浮船升降影响可能更大.通过对某10万m3钢储罐产生罐壁变形的原因分析和纠偏措施介绍,提出了一些大型储罐在安装过程中应注意的问题,给出了罐体顶升后间隙采用高压吹填的处理措施,对同类工程设计有一定的借鉴意义.

  18. 基于nRF24L01和Cortex-M3的无线测控系统%Wireless measurement and control system based on nRF24L01 and Cortex-M3

    Institute of Scientific and Technical Information of China (English)

    袁正道; 董丽莎; 王家斌

    2012-01-01

      在井下抢险或其它搜救现场,通常都需要一种远程遥测系统来取代人工进入一些危险场所。文中提出了一种基于nRF24L01和Cortex的无线测控系统的开发方法,简要讨论了其结构和开发原理,并详细介绍了该测控系统的硬件构造和软件开发流程%  On the downhole resuce and other rescue spot, a remote-measuring system is used to enter into the dangerous areas instead of persons. A design scheme of wireless measurement and control system based on RF24L01 and Cortex-M3 is given in the paper. In the paper a brief discussion on the structure and development principles of the system is made and the hardware construction and software development process are introduced in detail.

  19. Resource Abundance and Resource Dependence in China

    NARCIS (Netherlands)

    Ji, K.; Magnus, J.R.; Wang, W.

    2010-01-01

    This paper reconsiders the ‘curse of resources’ hypothesis for the case of China, and distinguishes between resource abundance, resource rents, and resource dependence. Resource abundance and resource rents are shown to be approximately equivalent, and their association with resource dependence vari

  20. Tilting structures in inverse perovskites, M3TtO (M = Ca, Sr, Ba, Eu; Tt = Si, Ge, Sn, Pb).

    Science.gov (United States)

    Nuss, Jürgen; Mühle, Claus; Hayama, Kyouhei; Abdolazimi, Vahideh; Takagi, Hidenori

    2015-06-01

    Single-crystal X-ray diffraction experiments were performed for a series of inverse perovskites, M3TtO (M = Ca, Sr, Ba, Eu; Tt = tetrel element: Si, Ge, Sn, Pb) in the temperature range 500-50 K. For Tt = Sn, Pb, they crystallize as an 'ideal' perovskite-type structure (Pm3m, cP5); however, all of them show distinct anisotropies of the displacement ellipsoids of the M atoms at room temperature. This behavior vanishes on cooling for M = Ca, Sr, Eu, and the structures can be regarded as `ideal' cubic perovskites at 50 K. The anisotropies of the displacement ellipsoids are much more enhanced in the case of the Ba compounds. Finally, their structures undergo a phase transition at ∼ 150 K. They change from cubic to orthorhombic (Ibmm, oI20) upon cooling, with slightly tilted OBa6 octahedra, and bonding angles O-Ba-O ≃ 174° (100 K). For the larger Ba(2+) cations, the structural changes are in agreement with smaller tolerance factors (t) as defined by Goldschmidt. Similar structural behavior is observed for Ca3TtO. Smaller Tt(4-) anions (Si, Ge) introduce reduced tolerance factors. Both compounds Ca3SiO and Ca3GeO with cubic structures at 500 K, change into orthorhombic (Ibmm) at room temperature. Whereby, Ca3SiO is the only representative within the M3TtO family where three polymorphs can be found within the temperature range 500-50 K: Pm3m-Ibmm-Pbnm. They show tiny differences in the tilting of the OCa6 octahedra, expressed by O-Ca-O bond angles of 180° (500 K), ∼ 174° (295 K) and 170° (100 K). For larger M (Sr, Eu, Ba), together with smaller Tt (Si, Ge) atoms, pronounced tilting of the OM6 octahedra, and bonding angles of O-M-O ≃ 160° (295 K) are observed. They crystallize in the anti-GdFeO3 type of structure (Pbnm, oP20), and no phase transitions occur between 500 and 50 K. The observed phase transitions are all accompanied by multiple twinning, in terms of pseudo-merohedry or reticular pseudo-merohedry.

  1. GABA(A) receptor M2-M3 loop secondary structure and changes in accessibility during channel gating.

    Science.gov (United States)

    Bera, Amal K; Chatav, Maya; Akabas, Myles H

    2002-11-08

    The gamma-aminobutyric acid type A (GABA(A)) receptor M2-M3 loop structure and its role in gating were investigated using the substituted cysteine accessibility method. Residues from alpha(1)Arg-273 to alpha(1)Ile-289 were mutated to cysteine, one at a time. MTSET(+) or MTSES(-) reacted with all mutants from alpha(1)R273C to alpha(1)Y281C, except alpha(1)P277C, in the absence and presence of GABA. The MTSET(+) closed-state reaction rate was >1000 liters/mol-s at alpha(1)N274C, alpha(1)S275C, alpha(1)K278C, and alpha(1)Y281C and was <300 liters/mol-s at alpha(1)R273C, alpha(1)L276C, alpha(1)V279C, alpha(1)A280C, and alpha(1)A284C. These two groups of residues lie on opposite sides of an alpha-helix. The fast reacting group lies on a continuation of the M2 segment channel-lining helix face. This suggests that the M2 segment alpha-helix extends about two helical turns beyond alpha(1)N274 (20'), aligned with the extracellular ring of charge. At alpha(1)S275C, alpha(1)V279C, alpha(1)A280C, and alpha(1)A284C the reaction rate was faster in the presence of GABA. The reagents had no functional effect on the mutants from alpha(1)A282C to alpha(1)I289C, except alpha(1)A284C. Access may be sterically hindered possibly by close interaction with the extracellular domain. We suggest that the M2 segment alpha-helix extends beyond the predicted extracellular end of the M2 segment and that gating induces a conformational change in and/or around the N-terminal half of the M2-M3 loop. Implications for coupling ligand-evoked conformational changes in the extracellular domain to channel gating in the membrane-spanning domain are discussed.

  2. Nanoscale Stabilization of New Phases in the PbTe-Sb2Te3 System: PbmSb2nTem+3n Nanocrystals

    Energy Technology Data Exchange (ETDEWEB)

    Soriano, Ronald B; Arachchige, Indika U; Malliakas, Christos D; Wu, Jinsong; Kanatzidis, Mercouri G [NWU

    2012-12-28

    A series of novel rock-salt-type PbmSb2nTem+3n nanocrystals (m = 2, 3, 4, 6, 8, and 10; n = 1 and 2) were successfully prepared using a colloidal synthesis route. These materials are stable only on the nanoscale and have no bulk analogues. Elemental compositions were determined using scanning transmission electron microscopy/energy-dispersive X-ray spectroscopy (STEM/EDS) and inductively coupled plasma atomic emission spectroscopy (ICP-AES). The nanocrystals exhibit well-defined band energies in the mid-IR region that are nearly independent of their atomic compositions. PbmSb2nTem+3n nanocrystals behave as metastable homogeneous solid solutions at room temperature and tend to phase separate into the respective binary PbTe + Sb2Te3 at 300 °C. Furthermore, pair distribution function (PDF) analysis suggests that the local structure of these PbmSb2nTem+3n nanocrystals is distorted with respect to the rock-salt structure.

  3. Algae Resources

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-06-01

    Algae are highly efficient at producing biomass, and they can be found all over the planet. Many use sunlight and nutrients to create biomass, which contain key components—including lipids, proteins, and carbohydrates— that can be converted and upgraded to a variety of biofuels and products. A functional algal biofuels production system requires resources such as suitable land and climate, sustainable management of water resources, a supplemental carbon dioxide (CO2) supply, and other nutrients (e.g., nitrogen and phosphorus). Algae can be an attractive feedstock for many locations in the United States because their diversity allows for highpotential biomass yields in a variety of climates and environments. Depending on the strain, algae can grow by using fresh, saline, or brackish water from surface water sources, groundwater, or seawater. Additionally, they can grow in water from second-use sources such as treated industrial wastewater; municipal, agricultural, or aquaculture wastewater; or produced water generated from oil and gas drilling operations.

  4. Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gbeta(5)-RGS7.

    Science.gov (United States)

    Sandiford, Simone L; Wang, Qiang; Levay, Konstantin; Buchwald, Peter; Slepak, Vladlen Z

    2010-06-22

    The complex of the regulator of G protein signaling (RGS), Gbeta(5)-RGS7, can inhibit signal transduction via the M3 muscarinic acetylcholine receptor (M3R). RGS7 consists of three distinct structural entities: the DEP domain and its extension DHEX, the Ggamma-like (GGL) domain, which is permanently bound to Gbeta subunit Gbeta(5), and the RGS domain responsible for the interaction with Galpha subunits. Inhibition of the M3R by Gbeta(5)-RGS7 is independent of the RGS domain but requires binding of the DEP domain to the third intracellular loop of the receptor. Recent studies identified the dynamic intramolecular interaction between the Gbeta(5) and DEP domains, which suggested that the Gbeta(5)-RGS7 dimer could alternate between the "open" and "closed" conformations. Here, we identified point mutations that weaken DEP-Gbeta(5) binding, presumably stabilizing the open state, and tested their effects on the interaction of Gbeta(5)-RGS7 with the M3R. We found that these mutations facilitated binding of Gbeta(5)-RGS7 to the recombinant third intracellular loop of the M3R but did not enhance its ability to inhibit M3R-mediated Ca(2+) mobilization. This led us to the idea that the M3R can effectively induce the Gbeta(5)-RGS7 dimer to open; such a mechanism would require a region of the receptor distinct from the third loop. Indeed, we found that the C-terminus of M3R interacts with Gbeta(5)-RGS7. Truncation of the C-terminus rendered the M3R insensitive to inhibition by wild-type Gbeta(5)-RGS7; however, the open mutant of Gbeta(5)-RGS7 was able to inhibit signaling by the truncated M3R. The GST fusion of the M3R C-tail could not bind to wild-type Gbeta(5)-RGS7 but could associate with its open mutant as well as with the separated recombinant DEP domain or Gbeta(5). Taken together, our data are consistent with the following model: interaction of the M3R with Gbeta(5)-RGS7 causes the DEP domain and Gbeta(5) to dissociate from each other and bind to the C-tail, and the DEP

  5. Underground low flux neutron background measurements in LSM using a large volume (1m3) spherical proportional counter

    Science.gov (United States)

    Savvidis, I.; Giomataris, I.; Bougamont, E.; Irastorza, I.; Aune, S.; Chapelier, M.; Charvin, P. H.; Colas, P.; Derre, J.; Ferrer, E.; Gerbier, G.; Gros, M.; Mangier, P.; Navick, X. F.; Salin, P.; Vergados, J. D.; Zampalo, M.

    2010-01-01

    A large volume (1m3) spherical proportional counter has been developed at CEA/Saclay, for low flux neutron measurements. The high voltage is applied to a small sphere 15mm in diameter, located in the center of the counter and the wall of the counter is grounded. Neutrons can be measured successfully, with high sensitivity, using 3He gas in the detector. The proton and tritium energy deposition in the drift gaseous volume, from the reaction 3He(n,p)3H, can provide the neutron spectra from thermal neutrons up to several MeV. The detector has been installed in the underground laboratory in Modane (LSM) to measure the neutron background. The sphere has been has been filled with gas mixture of Ar + 2% CH4 +3gr He-3, at 275 mbar. The thermal neutron peak is well separated from the cosmic ray and gamma background, permitting of neutron flux calculation. Other potential applications requiring large volume of about 10 m in radius are described in detail in reference

  6. Tests of shielding effectiveness of Kevlar and Nextel onboard the International Space Station and the Foton-M3 capsule.

    Science.gov (United States)

    Pugliese, M; Bengin, V; Casolino, M; Roca, V; Zanini, A; Durante, M

    2010-08-01

    Radiation assessment and protection in space is the first step in planning future missions to the Moon and Mars, where mission and number of space travelers will increase and the protection of the geomagnetic shielding against the cosmic radiation will be absent. In this framework, the shielding effectiveness of two flexible materials, Kevlar and Nextel, were tested, which are largely used in the construction of spacecrafts. Accelerator-based tests clearly demonstrated that Kevlar is an excellent shield for heavy ions, close to polyethylene, whereas Nextel shows poor shielding characteristics. Measurements on flight performed onboard of the International Space Station and of the Foton-M3 capsule have been carried out with special attention to the neutron component; shielded and unshielded detectors (thermoluminescence dosemeters, bubble detectors) were exposed to a real radiation environment to test the shielding properties of the materials under study. The results indicate no significant effects of shielding, suggesting that thin shields in low-Earth Orbit have little effect on absorbed dose.

  7. [Morphofunctional state of hepatocytes nuclear apparatus in Mongolian herbils after the flight on space apparatus Foton-M3].

    Science.gov (United States)

    Atiakshin, D A; Il'in, E A; Pashkov, A N

    2010-01-01

    Morphofunctional state of hepatocytes nuclear apparatus was analyzed in the liver of Mongolian gerbils Meriones unguiculatus returned from 12-d space flight of Foton-M3 (SF) and their vivarium and ground synchronous controls. Volume, ploidy and number of hepatocyte nuclei, nucleolus dimensions and number as well as contacts with karyolemma were determined in the central, intermediate and peripheral areas of the liver classical lobe. Also, total number of mitoses and amitoses was determined in the liver parenchyma. The vivarium control animals displayed specifics of the nucleus apparatus structure that depended on intralobe topography. Based on the selected criteria, high functional activity was characteristic of cells in the intermediate area. According to the criteria, nuclear apparatus in the synchronous control tended to down the functional activity The adaptive adjustment of nuclei in SF seemed to have been initiated by changes in the hepatic blood flow: volumes of hepatocyte nuclei and nucleoli increased as did the number of nuclei in cell, whereas ploidy made a decrease, especially in the intermediate area. Under the SF conditions, particularly important compensatory mechanism for the liver function was intensification of amitosis and consequent increase of the population of dinuclear hepatocytes.

  8. Full Stokes observations in the He I 1083 nm spectral region covering an M3.2 flare

    CERN Document Server

    Kuckein, C; Sainz, R Manso; Ramos, A Asensio

    2015-01-01

    We present an exceptional data set acquired with the Vacuum Tower Telescope (Tenerife, Spain) covering the pre-flare, flare, and post-flare stages of an M3.2 flare. The full Stokes spectropolarimetric observations were recorded with the Tenerife Infrared Polarimeter in the He I 1083.0 nm spectral region. The object under study was active region NOAA 11748 on 2013 May 17. During the flare the chomospheric He I 1083.0 nm intensity goes strongly into emission. However, the nearby photospheric Si I 1082.7 nm spectral line profile only gets shallower and stays in absorption. Linear polarization (Stokes Q and U) is detected in all lines of the He I triplet during the flare. Moreover, the circular polarization (Stokes V) is dominant during the flare, being the blue component of the He I triplet much stronger than the red component, and both are stronger than the Si I Stokes V profile. The Si I inversions reveal enormous changes of the photospheric magnetic field during the flare. Before the flare magnetic field conc...

  9. Reactor performance of a 750 m(3) anaerobic digestion plant: varied substrate input conditions impacting methanogenic community.

    Science.gov (United States)

    Wagner, Andreas Otto; Malin, Cornelia; Lins, Philipp; Gstraunthaler, Gudrun; Illmer, Paul

    2014-10-01

    A 750 m(3) anaerobic digester was studied over a half year period including a shift from good reactor performance to a reduced one. Various abiotic parameters like volatile fatty acids (VFA) (formic-, acetic-, propionic-, (iso-)butyric-, (iso-)valeric-, lactic acid), total C, total N, NH4 -N, and total proteins, as well as the organic matter content and dry mass were determined. In addition several process parameters such as temperature, pH, retention time and input of substrate and the concentrations of CH4, H2, CO2 and H2S within the reactor were monitored continuously. The present study aimed at the investigation of the abundance of acetogens and total cell numbers and the microbial methanogenic community as derived from PCR-dHPLC analysis in order to put it into context with the determined abiotic parameters. An influence of substrate quantity on the efficiency of the anaerobic digestion process was found as well as a shift from a hydrogenotrophic in times of good reactor performance towards an acetoclastic dominated methanogenic community in times of reduced reactor performance. After the change in substrate conditions it took the methano-archaeal community about 5-6 weeks to be affected but then changes occurred quickly.

  10. 75 FR 3471 - International Conference on Harmonisation; Guidance on M3(R2) Nonclinical Safety Studies for the...

    Science.gov (United States)

    2010-01-21

    ... . Submit written comments on the guidance to the Division of Dockets Management (HFA-305), Food and Drug... Pharmaceutical Industries Associations; the Japanese Ministry of Health, Labour, and Welfare; the Japanese.... Comments Interested persons may submit to the Division of Dockets Management (see ADDRESSES) electronic...

  11. Electronic Books for Secondary Students.

    Science.gov (United States)

    Anderson-Inman, Lynne; Horney, Mark

    1997-01-01

    Discusses the definition, purposes, and advantages and disadvantages of electronic books. Notes the types of embedded resources present in them, offers an example of an electronic book, and suggests three steps to evaluate and select electronic books for the curriculum. (SR)

  12. Data acquisition system of 16-channel EEG based on ATSAM3X8E ARM Cortex-M3 32-bit microcontroller and ADS1299

    Science.gov (United States)

    Toresano, L. O. H. Z.; Wijaya, S. K.; Prawito, Sudarmaji, A.; Badri, C.

    2017-07-01

    The prototype of the EEG (electroencephalogram) instrumentation systems has been developed based on 32-bit microcontrollers of Cortex-M3 ATSAM3X8E and Analog Front-End (AFE) ADS1299 (Texas Instruments, USA), and also consists of 16-channel dry-electrodes in the form of EEG head-caps. The ADS1299-AFE has been designed in a double-layer format PCB (Print Circuit Board) with daisy-chain configuration. The communication protocol of the prototype was based on SPI (Serial Peripheral Interface) and tested using USB SPI-Logic Analyzer Hantek4032L (Qingdao Hantek Electronic, China). The acquired data of the 16-channel from this prototype has been successfully transferred to a PC (Personal Computer) with accuracy greater than 91 %. The data acquisition system has been visualized with time-domain format in the multi-graph plotter, the frequency-domain based on FFT (Fast Fourier Transform) calculation, and also brain-mapping display of 16-channel. The GUI (Graphical User Interface) has been developed based on OpenBCI (Brain Computer Interface) using Java Processing and also can be stored of data in the *.txt format. Instrumentation systems have been tested in the frequency range of 1-50 Hz using MiniSim 330 EEG Simulator (NETECH, USA). The validation process has been done with different frequency of 0.1 Hz, 2 Hz, 5 Hz, and 50 Hz, and difference voltage amplitudes of 10 µV, 30 µV, 50 µV, 100 µV, 500 µV, 1 mV, 2 mV and 2.5 mV. However, the acquisition system was not optimal at a frequency of 0.1 Hz and for amplitude potentials of over 1 mV had differences of the order 10 µV.

  13. Changing M3G/M6G ratios and pharmacodynamics in a cancer patient during long-term morphine treatment

    DEFF Research Database (Denmark)

    Andersen, Gertrud; Christrup, Lona Louring; Sjøgren, Per;

    2002-01-01

    A cancer patient receiving long-term oral sustained-release morphine treatment and periodically presenting with unusually high plasma M3G/M6G ratios is described. We found the patient's formation of M6G more unstable and perhaps delayed compared to the formation of M3G. There is no apparent...... explanation for this phenomenon and the high M3G/M6G ratios had no implications for the patient's pain experience or side effects from the morphine treatment....

  14. Progress in TMT M3 system%TMT 望远镜三镜系统的研究进展

    Institute of Scientific and Technical Information of China (English)

    王富国; 杨飞; 赵宏超; 苏燕芹; 陈宝刚

    2013-01-01

    介绍30 m望远镜(TMT)的相关背景以及我国在TMT项目中承担的任务。从TMT三镜系统的总体要求出发,论述了三镜系统的两个主要部分(M3CA和M3PA)的具体要求、技术难点以及初步方案。针对M3CA,介绍了底支撑方案和侧支撑方案,采用Kinematic的底支撑方案时其面形精度RMS可以达到109.7 nm,SlopeRMS为0.95μrad,采用Kinematic的侧支撑方案时其面形精度RMS<15 nm,一阶谐振频率等于17.7 Hz,均达到了设计要求。针对M3PA,介绍了Tilt轴系和Rotator轴系的方案。最后,简要介绍了三镜控制系统(M3CS)的要求和目标。%The background of Thirty Meter Telescope(TMT) and its mission that we should take in hand are introdced.The detailed specifications and the preliminary scheme for the M 3CA and M3PA in the 3 mirror (M3) system are presented according to the general specification .Then, the two parts,axial support and later-al support of M3CA, are designed in detail.Due to the kinematic concept design used in both of axial support and lateral support, the mirror surface error can be reduced in a acceptable level .When the kinematic axial support scheme is taken, its surface accuracy RMS is 109.7 nm and Slope RMS is 0.95μrad, while the kine-matic lateral support scheme is taken, its surface accuracy RMS is 15 nm,and the first natural frequency can reach to 17.7 Hz.The design proposal for M3PA is discussed and the control system for M3 system(M3CS) is introduced briefly.

  15. 基于MDK RTX的Cortex-M3多任务应用设计%Multi-task Application Design Based on MDK RTX

    Institute of Scientific and Technical Information of China (English)

    方安平; 武永谊

    2008-01-01

    MDK RL-RTX是ARM公司推出的最新实时多任务内核,Cortex-M3是ARM公司最新发布的嵌入式处理器.将RL-RTX实时多任务内核应用到Cortex-M3处理器上,可大大提高代码密度,减少系统内存,提升系统性能.本文介绍了RL-RTX在Cortex-M3上的移植以及多任务应用设计方法.

  16. Using Predefined M3(μ3-O) Clusters as Building Blocks for an Isostructural Series of Metal-Organic Frameworks.

    Science.gov (United States)

    Peng, Li; Asgari, Mehrdad; Mieville, Pascal; Schouwink, Pascal; Bulut, Safak; Sun, Daniel T; Zhou, Zhongrui; Pattison, Philip; van Beek, Wouter; Queen, Wendy L

    2017-07-19

    Metal-organic frameworks (MOFs) have attracted much attention in the past decade owing to their unprecedented internal surface areas, tunable topologies, designable surfaces, and various potential applications. One bottleneck in the field regarding MOF synthesis is controlling the metal-containing secondary building unit (SBU) incorporated into the structure. In this work we report the synthesis and characterization of five trimeric [M3(μ3-O)(CH3CO2)6](x) clusters (where M = Fe(3+), Cr(3+), Fe(3+)/Cr(3+), Fe(3+)/Co(2+), or Fe(3+)/Ni(2+) and x = +1 or 0). The monocarboxylate capping ligand, acetate in this case, readily undergoes exchange with several difunctional counterparts, including 1,4-benzenedicarboxylic acid (H2-BDC) and biphenyl-4,4'-dicarboxylic acid (H2-BPDC), for the formation of an isostructural series of MOFs, several of which are newly reported (for M = Fe(3+)/Cr(3+), Fe(3+)/Co(2+), and Fe(3+)/Ni(2+)) and show excellent CO2 adsorption properties. In this report, a host of techniques including NMR, ICP, and ESI-MS are used to probe the ligand exchange process and composition of the SBUs, and XAS is used to monitor the Fe(3+) and Cr(3+) environment throughout the reactions, giving strong evidence that the clusters stay intact throughout the MOF synthesis. This work reveals that predefined SBUs is an effective means to create metal-substituted analogues of known frameworks. Further, CO adsorption and in situ IR are used to probe accessibility of the metals after solvent removal. We show for the first time that the incorporation of the neutral clusters, containing weaker Lewis acids like Ni(2+) and Co(2+), can promote the formation of open metal sites in the MOF frameworks, structural features known to enhance the binding energy of small guest molecules like CO2.

  17. Automotive electronics design fundamentals

    CERN Document Server

    Zaman, Najamuz

    2015-01-01

    This book explains the topology behind automotive electronics architectures and examines how they can be profoundly augmented with embedded controllers. These controllers serve as the core building blocks of today’s vehicle electronics. Rather than simply teaching electrical basics, this unique resource focuses on the fundamental concepts of vehicle electronics architecture, and details the wide variety of Electronic Control Modules (ECMs) that enable the increasingly sophisticated "bells & whistles" of modern designs.  A must-have for automotive design engineers, technicians working in automotive electronics repair centers and students taking automotive electronics courses, this guide bridges the gap between academic instruction and industry practice with clear, concise advice on how to design and optimize automotive electronics with embedded controllers.

  18. Energy resources

    CERN Document Server

    Simon, Andrew L

    1975-01-01

    Energy Resources mainly focuses on energy, including its definition, historical perspective, sources, utilization, and conservation. This text first explains what energy is and what its uses are. This book then explains coal, oil, and natural gas, which are some of the common energy sources used by various industries. Other energy sources such as wind, solar, geothermal, water, and nuclear energy sources are also tackled. This text also looks into fusion energy and techniques of energy conversion. This book concludes by explaining the energy allocation and utilization crisis. This publ

  19. A comparison between immunofluorescence staining on smears from Membrana nictitans (M3 test), immunohistopathology and routine pathology in cats with suspected feline infectious peritonitis (FIP).

    Science.gov (United States)

    Hök, K

    1991-01-01

    An indirect immunofluorescence method using smears from membrana nictitans (M3 test) to diagnose feline corona virus (FCV) infection was compared with immunohistopathology (using indirect immunofluorescence assay (IFFA) performed on organs (IFO], and routine pathology (RP) in cats with suspected feline infectious peritonitis (FIP). A close correlation between the 2 immunofluorescence methods (IFO and M3) was observed. Although the M3 test requires samples from only 1 organ per animal, both the sensitivity and specificity were high (80%), when compared to IFO (using samples from an average of 5 organs per animal). In 21% of the cats with suspected FIP typical pathological lesions were found. As the M3 test is relatively easy to perform, it could reduce work-load of pathology laboratories and provide valuable data for clinical and epidemiological use.

  20. The Biomedical Resource Ontology (BRO) to enable resource discovery in clinical and translational research.

    Science.gov (United States)

    Tenenbaum, Jessica D; Whetzel, Patricia L; Anderson, Kent; Borromeo, Charles D; Dinov, Ivo D; Gabriel, Davera; Kirschner, Beth; Mirel, Barbara; Morris, Tim; Noy, Natasha; Nyulas, Csongor; Rubenson, David; Saxman, Paul R; Singh, Harpreet; Whelan, Nancy; Wright, Zach; Athey, Brian D; Becich, Michael J; Ginsburg, Geoffrey S; Musen, Mark A; Smith, Kevin A; Tarantal, Alice F; Rubin, Daniel L; Lyster, Peter

    2011-02-01

    The biomedical research community relies on a diverse set of resources, both within their own institutions and at other research centers. In addition, an increasing number of shared electronic resources have been developed. Without effective means to locate and query these resources, it is challenging, if not impossible, for investigators to be aware of the myriad resources available, or to effectively perform resource discovery when the need arises. In this paper, we describe the development and use of the Biomedical Resource Ontology (BRO) to enable semantic annotation and discovery of biomedical resources. We also describe the Resource Discovery System (RDS) which is a federated, inter-institutional pilot project that uses the BRO to facilitate resource discovery on the Internet. Through the RDS framework and its associated Biositemaps infrastructure, the BRO facilitates semantic search and discovery of biomedical resources, breaking down barriers and streamlining scientific research that will improve human health. Copyright © 2010 Elsevier Inc. All rights reserved.

  1. The Biomedical Resource Ontology (BRO) to Enable Resource Discovery in Clinical and Translational Research

    Science.gov (United States)

    Tenenbaum, Jessica D.; Whetzel, Patricia L.; Anderson, Kent; Borromeo, Charles D.; Dinov, Ivo D.; Gabriel, Davera; Kirschner, Beth; Mirel, Barbara; Morris, Tim; Noy, Natasha; Nyulas, Csongor; Rubenson, David; Saxman, Paul R.; Singh, Harpreet; Whelan, Nancy; Wright, Zach; Athey, Brian D.; Becich, Michael J.; Ginsburg, Geoffrey S.; Musen, Mark A.; Smith, Kevin A.; Tarantal, Alice F.; Rubin, Daniel L; Lyster, Peter

    2010-01-01

    The biomedical research community relies on a diverse set of resources, both within their own institutions and at other research centers. In addition, an increasing number of shared electronic resources have been developed. Without effective means to locate and query these resources, it is challenging, if not impossible, for investigators to be aware of the myriad resources available, or to effectively perform resource discovery when the need arises. In this paper, we describe the development and use of the Biomedical Resource Ontology (BRO) to enable semantic annotation and discovery of biomedical resources. We also describe the Resource Discovery System (RDS) which is a federated, inter-institutional pilot project that uses the BRO to facilitate resource discovery on the Internet. Through the RDS framework and its associated Biositemaps infrastructure, the BRO facilitates semantic search and discovery of biomedical resources, breaking down barriers and streamlining scientific research that will improve human health. PMID:20955817

  2. The use of occupation isoboles for analysis of a response mediated by two receptors: M2 and M3 muscarinic receptor subtype-induced mouse stomach contractions.

    Science.gov (United States)

    Braverman, Alan S; Tallarida, Ronald J; Ruggieri, Michael R

    2008-06-01

    Smooth muscle contains multiple muscarinic receptor subtypes, including M2 and M3. M2 receptors outnumber M3 receptors. Based on the potency of subtype selective anticholinergics, contraction is mediated by the M3 subtype. However, results from knockout (KO) mice show that the M2 receptor mediates approximately 45% of the contractile response produced by the M3 receptor. The traditional theory of one receptor mediating a response does not allow assessment of interactions between receptors when more than one receptor participates in a response. Our study was performed using a novel analysis method based on dual receptor occupancy to determine how M2 and M3 receptor subtypes interact to mediate contraction in mouse stomach. Cumulative carbachol concentration contractile responses were determined for wild-type, M2-KO, and M3-KO stomach body smooth muscle. Using affinity constants for carbachol at M2 and M3 cholinergic receptors, the concentration values were converted to fractional receptor occupation. The resulting occupation-effect relations showed maximum effects for the M2 and M3 subtypes, respectively. These occupation-effect relations allow determination of the additive (expected) isobole based on this dual occupancy, thereby providing a curve (mathematically derived) for comparison against the experimentally derived value in wild type. The actual values determined experimentally in the wild type were not statistically significantly different from that predicted by the isobole. This confirms that the interaction between these mutually occupied receptors is additive. The new method of analysis also expands the traditional Schild theory that was based on a single receptor type to which the agonist and antagonist bind.

  3. PDA对我国外文电子期刊资源联合采购的影响研究%Study on the Inlfuence of Patron Driven Acquisition(PDA)on the Joint Purchase of the Foreign Electronic Periodical Resources Libraries

    Institute of Scientific and Technical Information of China (English)

    吴进琼

    2016-01-01

    Patron driven Acquisition,PDA(读者决策采购)在国外图书馆电子图书联合采购中效益非常明显。如果把它引进我国高校图书馆电子期刊文献资源特别是外文电子期刊联合采购中,将会对我国的电子期刊文献资源建设起到非常重要的作用。本文主要对把读者决策采购PDA模式对我国高校图书馆外文电子期刊文献资源联合采购的影响进行论述。%The Benefit of Patron-driven Acquisition(PDA)is very obvious in the foreign library electronic book purchase.PDA will play an very important role to our country's electronic resources construction especially foreign electronic journal if it is introduced into the electronic journal literature resources joint purchase in our country university libraries.This article mainly discusses the influence of the PDA mode on the purchase of the foreign electronic journals of University Libraries in China.

  4. The insect repellent N,N-diethyl-m-toluamide (DEET) induces angiogenesis via allosteric modulation of the M3 muscarinic receptor in endothelial cells.

    Science.gov (United States)

    Legeay, Samuel; Clere, Nicolas; Hilairet, Grégory; Do, Quoc-Tuan; Bernard, Philippe; Quignard, Jean-François; Apaire-Marchais, Véronique; Lapied, Bruno; Faure, Sébastien

    2016-06-27

    The insect repellent N,N-diethyl-m-toluamide (DEET) has been reported to inhibit AChE (acetylcholinesterase) and to possess potential carcinogenic properties with excessive vascularization. In the present paper, we demonstrate that DEET specifically stimulates endothelial cells that promote angiogenesis which increases tumor growth. DEET activates cellular processes that lead to angiogenesis including proliferation, migration and adhesion. This is associated with an enhancement of NO production and VEGF expression in endothelial cells. M3 silencing or the use of a pharmacological M3 inhibitor abrogates all of these effects which reveals that DEET-induced angiogenesis is M3 sensitive. The experiments involving calcium signals in both endothelial and HEK cells overexpressing M3 receptors, as well as binding and docking studies demonstrate that DEET acts as an allosteric modulator of the M3 receptor. In addition, DEET inhibited AChE which increased acetylcholine bioavailability and binding to M3 receptors and also strengthened proangiogenic effects by an allosteric modulation.

  5. Real-time monitoring of genetically modified Chlamydomonas reinhardtii during the Foton M3 space mission and ground irradiation experiment

    Science.gov (United States)

    Lambreva, Maya; Rea, Giuseppina; Antonacci, Amina; Serafini, Agnese; Damasso, Mario; Margonelli, Andrea; Johanningmeier, Udo; Bertalan, Ivo; Pezzotti, Gianni; Giardi, Maria Teresa

    Long-term space exploration, colonization or habitation requires biological life support systems capable to cope with the deleterious space environment. The use of oxygenic photosynthetic microrganisms is an intriguing possibility mainly for food, O2 and nutraceutical compounds production. The critical points of utilizing plantsor algae-based life support systems are the microgravity and the ionizing radiation, which can influence the performance of these organisms. The aim of the present study was to assess the effects of space environment on the photosynthetic activity of various microrganisms and to select space stress-tolerant strains. Site-directed and random mutants of the unicellular green alga Chlamydomonas reinhardtii of Photosystem II D1 protein were used as a model system to test and select the amino acid substitutions capable to account for space stress tolerance. We focussed our studies also on the accumulation of the Photosystem II photoprotective carotenoids (the xantophylls violaxanthin, anteraxanthin and zeaxanthin), powerful antioxidants that epidemiological studies demonstrated to be human vision protectors. Metabolite profiling by quantitative HPLC methods revealed the organisms and the stress conditions capable to accumulate the highest pigment levels. In order to develop a project for a rationale metabolic engineering of algal secondary metabolites overproduction, we are performing expression analyses on the carotenoid biosynthetic pathway under physiological and mimicked space conditions. To identify the consequences of the space environment on the photosynthetic apparatus the changes in the Photosystem II efficiency were monitored in real time during the ESA-Russian Foton-M3 mission in September 2007. For the space flight a high-tech, multicell fluorescence biosensor, Photo-II, was designed and built by the Centre for Advanced Research in Space Optics in collaboration with Kayser-Italy, Biosensor and DAS. Photo-II is an automatic device

  6. Open Educational Resources (1): Wat hebben we nodig?

    NARCIS (Netherlands)

    Westera, Wim

    2010-01-01

    Westera, W. (2010). Open Educational Resources (1): Wat hebben we nodig? Electronic article on SURFspace. SURF foundation: Utrecht. Retrieved december 14 at http://www.surfspace.nl/nl/Artikelen/Pages/OpenEducationalResources(1)Wathebbenwenodig.aspx

  7. Open Educational Resources (2): Hoe dekken we de kosten?

    NARCIS (Netherlands)

    Westera, Wim

    2010-01-01

    Westera, W. (2010). Open Educational Resources (2): Hoe dekken we de kosten? Electronic article on SURFspace. SURF foundation: Utrecht. Retrieved december 14 at http://www.surfspace.nl/nl/Artikelen/Pages/OpenEducationalResources(2)Hoedekkenwedekosten.aspx

  8. Lunar Net—a proposal in response to an ESA M3 call in 2010 for a medium sized mission

    Science.gov (United States)

    Smith, Alan; Crawford, I. A.; Gowen, Robert Anthony; Ambrosi, R.; Anand, M.; Banerdt, B.; Bannister, N.; Bowles, N.; Braithwaite, C.; Brown, P.; Chela-Flores, J.; Cholinser, T.; Church, P.; Coates, A. J.; Colaprete, T.; Collins, G.; Collinson, G.; Cook, T.; Elphic, R.; Fraser, G.; Gao, Y.; Gibson, E.; Glotch, T.; Grande, M.; Griffiths, A.; Grygorczuk, J.; Gudipati, M.; Hagermann, A.; Heldmann, J.; Hood, L. L.; Jones, A. P.; Joy, K. H.; Khavroshkin, O. B.; Klingelhoefer, G.; Knapmeyer, M.; Kramer, G.; Lawrence, D.; Marczewski, W.; McKenna-Lawlor, S.; Miljkovic, K.; Narendranath, S.; Palomba, E.; Phipps, A.; Pike, W. T.; Pullan, D.; Rask, J.; Richard, D. T.; Seweryn, K.; Sheridan, S.; Sims, M.; Sweeting, M.; Swindle, T.; Talboys, D.; Taylor, L.; Teanby, N.; Tong, V.; Ulamec, S.; Wawrzaszek, R.; Wieczorek, M.; Wilson, L.; Wright, I.

    2012-04-01

    Emplacement of four or more kinetic penetrators geographically distributed over the lunar surface can enable a broad range of scientific exploration objectives of high priority and provide significant synergy with planned orbital missions. Whilst past landed missions achieved a great deal, they have not included a far-side lander, or investigation of the lunar interior apart from a very small area on the near side. Though the LCROSS mission detected water from a permanently shadowed polar crater, there remains in-situ confirmation, knowledge of concentration levels, and detailed identification of potential organic chemistry of astrobiology interest. The planned investigations will also address issues relating to the origin and evolution of the Earth-Moon system and other Solar System planetary bodies. Manned missions would be enhanced with use of water as a potential in-situ resource; knowledge of potential risks from damaging surface Moonquakes, and exploitation of lunar regolith for radiation shielding. LunarNet is an evolution of the 2007 LunarEX proposal to ESA (European Space Agency) which draws on recent significant advances in mission definition and feasibility. In particular, the successful Pendine full-scale impact trials have proved impact survivability for many of the key technology items, and a penetrator system study has greatly improved the definition of descent systems, detailed penetrator designs, and required resources. LunarNet is hereby proposed as an exciting stand-alone mission, though is also well suited in whole or in-part to contribute to the jigsaw of upcoming lunar missions, including that of a significant element to the ILN (International Lunar Network).

  9. The Use of Resources in Resource Acquisition

    OpenAIRE

    Wernerfelt, Birger

    2010-01-01

    The author considers the processes through which a firm can acquire resources and argues that its current stock of resources create asymmetries in competition for new resources. Two simple models illustrate how this can work through linkages on the demand and/or cost side. The normative implication is that firms should expand their resource portfolios by building on their existing resources; different firms will then acquire different new resources, and small initial heterogeneities will ampl...

  10. Research on adverse drug events. I. Muscarinic M3 receptor binding affinity could predict the risk of antipsychotics to induce type 2 diabetes.

    Science.gov (United States)

    Silvestre, J S; Prous, J

    2005-06-01

    Antipsychotics are associated with a wide range of adverse effects, several of which may represent a serious health risk to patients. There is an increased concern about metabolic disturbances associated with antipsychotics, including weight gain, dyslipidemia, hyperglycemia, and type 2 diabetes. However, little is known about the mechanisms underlying antipsychotic-induced metabolic disturbances and, in particular, those related to the induction of abnormal glucose metabolism and diabetes. The present article aimed to identify those receptor(s) that are most likely to be involved with or mediate antipsychotics-induced diabetes. Two independent measures taken from literature to indicate the risk of type 2 diabetes associated with 25 typical and atypical antipsychotic drugs were considered, along with their binding affinities to 21 specific receptors (obtained from the resources of Prous Science Integrity). A range of both exploratory and predictive statistical analyses were applied, including principal component factorial analysis, multivariable linear regression analysis, and discriminant analysis. Binding affinities (pKi) to human neurotransmitter receptors and monoaminergic transporters were used as independent variables (predictors). Measures to determine the risk to induce new-onset type 2 diabetes associated with each antipsychotic, logistic regression odds-ratio (dOR) and a discrete scale-based risk (three levels: 'low,' 'moderate,' 'high'), were used as the dependent variables (criteria). Similarly, parallel analyses were also conducted for other measures (average effective therapeutic dose) or adverse effects (weight gain, extrapyramidal side effects, hyperprolactinemia, anticholinergic, hypotension, and sedation) associated with antipsychotics, where underlying mechanisms have been previously established and, therefore, serve as positive-control references. Affinity for the cholinergic muscarinic M3 receptor subtype was presented as the best predictor for

  11. Comprehensive Epidemiologic Data Resource (CEDR) (Poster)

    Energy Technology Data Exchange (ETDEWEB)

    Oak Ridge Institute for Science and Education (ORISE)

    2012-12-12

    This poster introduces the Comprehensive Epidemiologic Data Resource (CEDR), an electronic database with demographic, health outcome, and exposure information for over a million DOE nuclear plant and laboratory workers.

  12. The M3 phosphorylation site is required for trafficking and biological roles of PIN-FORMED1, 2, and 7 in Arabidopsis

    Directory of Open Access Journals (Sweden)

    Daeeun Ki

    2016-09-01

    Full Text Available Asymmetrically localized PIN-FORMED (PIN auxin efflux carriers play key roles in regulating directional intercellular auxin movement, generating local auxin gradients, and diverse auxin-mediated growth and development. The polar localization of PINs is controlled by phosphorylation in the central hydrophilic loop (HL of PINs. Although the M3 phosphorylation site, including phosphorylatable 5 Ser/Thr residues, is conserved among long HL-PINs, its native role has only been characterized in PIN3. In this study, we examined the role of M3 phosphorylation site of PIN1, PIN2, and PIN7 in intracellular trafficking, phosphorylation, and biological functions of those PINs in their native expressing tissues. Phosphorylation-defective mutations of the phosphorylatable residues in the M3 site of PIN1-HL led to alteration in subcellular polarity of PIN1 and caused defects in PIN1-mediated biological functions such as cotyledon development, phyllotaxy of vegetative leaves, and development of reproductive organs. The M3 mutations of PIN7 interfered with its polar recycling in the root columella cell in response to gravity stimulus and partially disrupted root gravitropism. On the other hand, the M3 site of PIN2 was shown to be necessary for its targeting to the plasma membrane. In vitro phosphorylation assay showed that the M3 phosphorylation residues of PIN1 are the partial targets by PINOID kinase. Our data suggest that the M3 phosphorylation site is functionally conserved among long HL-PINs by playing roles for their subcellular trafficking and auxin-mediated developmental processes.

  13. The M3 Phosphorylation Site Is Required for Trafficking and Biological Roles of PIN-FORMED1, 2, and 7 in Arabidopsis

    Science.gov (United States)

    Ki, Daeeun; Sasayama, Daisuke; Cho, Hyung-Taeg

    2016-01-01

    Asymmetrically localized PIN-FORMED (PIN) auxin efflux carriers play key roles in regulating directional intercellular auxin movement, generating local auxin gradients, and diverse auxin-mediated growth and development. The polar localization of PINs is controlled by phosphorylation in the central hydrophilic loop (HL) of PINs. Although the M3 phosphorylation site, including phosphorylatable 5 Ser/Thr residues, is conserved among long HL-PINs, its native role has only been characterized in PIN3. In this study, we examined the role of M3 phosphorylation site of PIN1, PIN2, and PIN7 in intracellular trafficking, phosphorylation, and biological functions of those PINs in their native expressing tissues. Phosphorylation-defective mutations of the phosphorylatable residues in the M3 site of PIN1-HL led to alteration in subcellular polarity of PIN1 and caused defects in PIN1-mediated biological functions such as cotyledon development, phyllotaxy of vegetative leaves, and development of reproductive organs. The M3 mutations of PIN7 interfered with its polar recycling in the root columella cell in response to gravity stimulus and partially disrupted root gravitropism. On the other hand, the M3 site of PIN2 was shown to be necessary for its targeting to the plasma membrane. In vitro phosphorylation assay showed that the M3 phosphorylation residues of PIN1 are the partial targets by PINOID kinase. Our data suggest that the M3 phosphorylation site is functionally conserved among long HL-PINs by playing roles for their subcellular trafficking and auxin-mediated developmental processes.

  14. Hard electronics; Hard electronics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    In the fields of power conversion devices and broadcasting/communication amplifiers, high power, high frequency and low losses are desirable. Further, for electronic elements in aerospace/aeronautical/geothermal surveys, etc., heat resistance to 500degC is required. Devices which respond to such hard specifications are called hard electronic devices. However, with Si which is at the core of the present electronics, the specifications cannot fully be fulfilled because of the restrictions arising from physical values. Accordingly, taking up new device materials/structures necessary to construct hard electronics, technologies to develop these to a level of IC were examined and studied. They are a technology to make devices/IC of new semiconductors such as SiC, diamond, etc. which can handle higher temperature, higher power and higher frequency than Si and also is possible of reducing losses, a technology to make devices of hard semiconducter materials such as a vacuum microelectronics technology using ultra-micro/high-luminance electronic emitter using negative electron affinity which diamond, etc. have, a technology to make devices of oxides which have various electric properties, etc. 321 refs., 194 figs., 8 tabs.

  15. Electronic Cigarettes

    Science.gov (United States)

    ... New FDA Regulations Text Size: A A A Electronic Cigarettes Electronic cigarettes (e-cigarettes) are battery operated products designed ... more about: The latest news and events about electronic cigarettes on this FDA page Electronic cigarette basics ...

  16. Experiment lithopanspermia: test of interplanetary transfer and re-entry process of epi- and endolithic microbial communities in the FOTON-M3 Mission

    Science.gov (United States)

    de La Torre Noetzel, Rosa

    The Lithopanspermia hypothesis assumes that impact-expelled rocks serve as interplanetary transfer vehicles for microorganisms colonizing those rocks. It requires that the microorganisms survive (1) the impact ejection process from the planet of origin; (2) travelling through space; (3) capture and landing on another planet. In the experiment "Lithopanspermia" on board of the FOTON-M3 satellite (14.09.07) steps 2 and 3 of this scenario have been experimentally tested. Assay systems for step 2 were the bipolar epilithic lichen species Rhizocarpon geographicum and Xanthoria elegans on their natural rock substrate as well as their reproduction structures, microbial communities from atacamás halites Chroococcidiopsiss, endolithic communities of Anabaena and Nostoc, and the vagrant lichen species Aspicilia fruticulosa. The samples were exposed to outer space conditions within the BIOPAN-6 facility of ESA. Preparatory space simulation studies (UV solar spectrum radiation and vacuum at 10-2 Pa) performed at the Spasolab-Laboratory of INTA (March-April 2007), have demonstrated the suitability of those lichen species. After flight (10 days exposure to harsh space conditions in low Earth orbit at about 300 km altitude) and recovery, the survival capacity of the microbial communities has been assayed. First analyses have confirmed a fast recovery of the biological activity (chlorophyll a- fluorescence) of the lichens, similar to the high survival rates observed in the experiment LICHENS onboard of the Foton-M2 mission (de la Torre et al., 2007; Sancho et al., 2007). There were no significant changes in relation with the pre-flight values of the epilithic-, endolithicand vagrant lichen samples. First results of Confocal Scanning Laser Microscopy have demonstrated a high vitality of epilithic samples. Ultrastructural changes are being analyzed by Transmission Electron Microscopy and Cryoscanning. Furthermore, concerning the germination capacity of ascospores of Xanthoria

  17. Quantitation of the Contractile Response Mediated by Two Receptors: M2 and M3 Muscarinic Receptor-Mediated Contractions of Human Gastroesophageal Smooth MuscleS⃞

    Science.gov (United States)

    Braverman, Alan S.; Miller, Larry S.; Vegesna, Anil K.; Tiwana, Mansoor I.; Tallarida, Ronald J.; Ruggieri, Michael R.

    2009-01-01

    Although muscarinic receptors are known to mediate tonic contraction of human gastrointestinal tract smooth muscle, the receptor subtypes that mediate the tonic contractions are not entirely clear. Whole human stomachs with attached esophagus were procured from organ transplant donors. Cholinergic contractile responses of clasp, sling, lower esophageal circular (LEC), midesophageal circular (MEC), and midesophageal longitudinal (MEL) muscle strips were determined. Sling fibers contracted greater than the other fibers. Total, M2 and M3 muscarinic receptor density was determined for each of these dissections by immunoprecipitation. M2 receptor density is greatest in the sling fibers, followed by clasp, LEC, MEC, and then MEL, whereas M3 density is greatest in LEC, followed by MEL, MEC, sling, and then clasp. The potency of subtype-selective antagonists to inhibit bethanechol-induced contraction was calculated by Schild analysis to determine which muscarinic receptor subtypes contribute to contraction. The results suggest both M2 and M3 receptors mediate contraction in clasp and sling fibers. Thus, this type of analysis in which multiple receptors mediate the contractile response is inappropriate, and an analysis method relating dual occupation of M2 and M3 receptors to contraction is presented. Using this new method of analysis, it was found that the M2 muscarinic receptor plays a greater role in mediating contraction of clasp and sling fibers than in LEC, MEC, and MEL muscles in which the M3 receptor predominantly mediates contraction. PMID:19126780

  18. Quantitation of the contractile response mediated by two receptors: M2 and M3 muscarinic receptor-mediated contractions of human gastroesophageal smooth muscle.

    Science.gov (United States)

    Braverman, Alan S; Miller, Larry S; Vegesna, Anil K; Tiwana, Mansoor I; Tallarida, Ronald J; Ruggieri, Michael R

    2009-04-01

    Although muscarinic receptors are known to mediate tonic contraction of human gastrointestinal tract smooth muscle, the receptor subtypes that mediate the tonic contractions are not entirely clear. Whole human stomachs with attached esophagus were procured from organ transplant donors. Cholinergic contractile responses of clasp, sling, lower esophageal circular (LEC), midesophageal circular (MEC), and midesophageal longitudinal (MEL) muscle strips were determined. Sling fibers contracted greater than the other fibers. Total, M(2) and M(3) muscarinic receptor density was determined for each of these dissections by immunoprecipitation. M(2) receptor density is greatest in the sling fibers, followed by clasp, LEC, MEC, and then MEL, whereas M(3) density is greatest in LEC, followed by MEL, MEC, sling, and then clasp. The potency of subtype-selective antagonists to inhibit bethanechol-induced contraction was calculated by Schild analysis to determine which muscarinic receptor subtypes contribute to contraction. The results suggest both M(2) and M(3) receptors mediate contraction in clasp and sling fibers. Thus, this type of analysis in which multiple receptors mediate the contractile response is inappropriate, and an analysis method relating dual occupation of M(2) and M(3) receptors to contraction is presented. Using this new method of analysis, it was found that the M(2) muscarinic receptor plays a greater role in mediating contraction of clasp and sling fibers than in LEC, MEC, and MEL muscles in which the M(3) receptor predominantly mediates contraction.

  19. Microwave irradiation induces neurite outgrowth in PC12m3 cells via the p38 mitogen-activated protein kinase pathway.

    Science.gov (United States)

    Inoue, Shigeki; Motoda, Hirotoshi; Koike, Yoshihisa; Kawamura, Kenji; Hiragami, Fukumi; Kano, Yoshio

    2008-02-13

    The increasing use of mobile phone communication has raised concerns about possible health hazard effects of microwave irradiation. We investigated damage and differentiation caused by microwave irradiation on drug-hypersensitive PC12 cell line (PC12m3). These cells showed enhancement of neurite outgrowth to various stimulants. The frequency of neurite outgrowth induced by 2.45 GHz (200 W) of microwave irradiation was approximately 10-fold greater than that of non-irradiated control cells. Incubation of PC12m3 cells with SB203580, a specific inhibitor of p38 MAPK, resulted in marked inhibition of the microwave radiation-induced neurite outgrowth. Also, activation of the transcription factor CREB induced by microwave irradiation was inhibited by SB203580. Heat shock treatment at 45 degrees C had a strong toxic effect on PC12m3 cells, whereas microwave treatment had no toxic effect on PC12m3 cells. These findings indicate that p38 MAPK is responsible for the survival of PC12m3 cells and might induce neurite outgrowth via a CREB signaling pathway when subjected to microwave irradiation.

  20. Virtual Screening of M3 Protein Antagonists for Finding a Model to Study the Gammaherpesvirus Damaged Immune System and Chemokine Related Diseases

    Directory of Open Access Journals (Sweden)

    Ibrahim Torktaz

    2013-12-01

    Full Text Available Introduction: M3 protein is a chemokine decoy receptor involved in pathogenesis of persistent infection with gammaherpesvirus and complications related to the latency of this pathogen. We proposed that antagonists of the M3 would provide a unique opportunity for studying new therapeutic strategies in disordered immune system, immune-deficient states and role of chemokines in pathogenesis development. Methods: Comparative modeling and fold recognition algorithms have been used for prediction of M3 protein 3-D model. Evaluation of the models using Q-mean and ProSA-web score, has led to choosing predicted model by fold recognition algorithm as the best model which was minimized regarding energy level using Molegro Virtual Docker 2011.4.3.0 (MVD software. Pockets and active sites of model were recognized using MVD cavity detection, and MetaPocket algorithms. Ten thousand compounds accessible on KEGG database were screened; MVD was used for computer simulated docking study; MolDock SE was selected as docking scoring function and final results were evaluated based on MolDock and Re-rank score. Results: Docking data suggested that prilocaine, which is generally applied as a topical anesthetic, binds strongly to 3-D model of M3 protein. Conclusion: This study proposes that prilocaine is a potential inhibitor of M3 protein and possibly has immune enhancing properties.

  1. The Electron

    Energy Technology Data Exchange (ETDEWEB)

    Thomson, George

    1972-01-01

    Electrons are elementary particles of atoms that revolve around and outside the nucleus and have a negative charge. This booklet discusses how electrons relate to electricity, some applications of electrons, electrons as waves, electrons in atoms and solids, the electron microscope, among other things.

  2. Hard electronics; Hard electronics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    Hard material technologies were surveyed to establish the hard electronic technology which offers superior characteristics under hard operational or environmental conditions as compared with conventional Si devices. The following technologies were separately surveyed: (1) The device and integration technologies of wide gap hard semiconductors such as SiC, diamond and nitride, (2) The technology of hard semiconductor devices for vacuum micro- electronics technology, and (3) The technology of hard new material devices for oxides. The formation technology of oxide thin films made remarkable progress after discovery of oxide superconductor materials, resulting in development of an atomic layer growth method and mist deposition method. This leading research is expected to solve such issues difficult to be easily realized by current Si technology as high-power, high-frequency and low-loss devices in power electronics, high temperature-proof and radiation-proof devices in ultimate electronics, and high-speed and dense- integrated devices in information electronics. 432 refs., 136 figs., 15 tabs.

  3. Research on sub-surface damage and its stress deformation in the process of large aperture and high diameter-to-thickness ratio TMT M3MP

    Science.gov (United States)

    Hu, Hai-xiang; Qi, Erhui; Cole, Glen; Hu, Hai-fei; Luo, Xiao; Zhang, Xue-jun

    2016-10-01

    Large flat mirrors play important roles in large aperture telescopes. However, they also introduce unpredictable problems. The surface errors created during manufacturing, testing, and supporting are all combined during measurement, thus making understanding difficult for diagnosis and treatment. Examining a high diameter-to-thickness ratio flat mirror, TMT M3MP, and its unexpected deformation during processing, we proposed a strain model of subsurface damage to explain the observed phenomenon. We designed a set of experiment, and checked the validity of our diagnosis. On that basis, we theoretical predicted the trend of this strain and its scale effect on Zerodur®, and checked the validity on another piece experimentally. This work guided the grinding-polishing process of M3MP, and will be used as reference for M3M processing as well.

  4. Electronic Resources and Web Sites: Replacing a Back-end Database with Innovative's Electronic Resource Management

    National Research Council Canada - National Science Library

    Laura Tull

    2005-01-01

    .... This article focuses on one aspect of ERM, the integration of the module with the Web OPAC, and describes how the Ohio State University Libraries replaced a back-end database with ERM to support...

  5. Shaping the Electronic Library--The UW-Madison Approach.

    Science.gov (United States)

    Dean, Charles W., Ed.; Frazier, Ken; Pope, Nolan F.; Gorman, Peter C.; Dentinger, Sue; Boston, Jeanne; Phillips, Hugh; Daggett, Steven C.; Lundquist, Mitch; McClung, Mark; Riley, Curran; Allan, Craig; Waugh, David

    1998-01-01

    This special theme section describes the University of Wisconsin-Madison's experience building its Electronic Library. Highlights include integrating resources and services; the administrative framework; the public electronic library, including electronic publishing capability and access to World Wide Web-based and other electronic resources;…

  6. Comparison of Transport Calculation Between 2D/1D synthesis and RAPTOR-M3G at Core Barrel of Korea Standard Nuclear Plant(KSNP), OPR-1000

    Energy Technology Data Exchange (ETDEWEB)

    Maeng, Young Jae; Kim, Byoung Chul; Lim, Mi Joung; Kim, Kyung Sik; Jeon, Young Kyou [Korea Reactor Integrity Surveillance Technology, Daejeon (Korea, Republic of); Yoo, Chun Sung [Korea Atomic Energy Research Institutes, Daejeon (Korea, Republic of)

    2013-10-15

    The DORT code for 2D/1D synthesis has been actively applied to calculate the fast neutron (E>1.0MeV) fluence exposure of RPV. RAPTOR-M3G code is also applied for the comparison of 2D/1D synthesis, and it was found that 2D/1D synthesis method generally provided more conservative results than RAPTOR-M3G at both RPV and surveillance capsule locations. As a result, definitely RAPTOR-M3G for 3D calculation must apply for accurate evaluation of the integrity and ageing of RPV and internal structures. Therefore, the purpose of this paper is to compare the differences in terms of geometric aspect of KSNP model between 2D/1D synthesis and RAPTOR-M3G at core barrel area. 2D/1D synthesis method shows still higher results at the shortest distance of bypass water region. The reason is that 2D/1D synthesis method has excessive conservatism because of having just one model of R-θ and R-Z separately. Angles (5, 25, 45, 65 and 90 degrees) that RAPTOR-M3G results are higher than 2D/1D synthesis results seem to have almost regular interval. The reason can be that neutron flux to reach to barrel is affected by the nearest core definitely and all of near core areas including bypass water. RAPTOR-M3G performing 3D calculation can be applied to various reactor structures, because the code can simulate the model realistically and reasonably in geometric view points. Understanding the phenomenon that 45 degree shows downward peak, in spite of baffle corner location, remains.

  7. Length and amino acid sequence of peptides substituted for the 5-HT3A receptor M3M4 loop may affect channel expression and desensitization.

    Directory of Open Access Journals (Sweden)

    Nicole K McKinnon

    Full Text Available 5-HT3A receptors are pentameric neurotransmitter-gated ion channels in the Cys-loop receptor family. Each subunit contains an extracellular domain, four transmembrane segments (M1, M2, M3, M4 and a 115 residue intracellular loop between M3 and M4. In contrast, the M3M4 loop in prokaryotic homologues is <15 residues. To investigate the limits of M3M4 loop length and composition on channel function we replaced the 5-HT3A M3M4 loop with two to seven alanine residues (5-HT3A-A(n = 2-7. Mutants were expressed in Xenopus laevis oocytes and characterized using two electrode voltage clamp recording. All mutants were functional. The 5-HT EC(50's were at most 5-fold greater than wild-type (WT. The desensitization rate differed significantly among the mutants. Desensitization rates for 5-HT3A-A(2, 5-HT3A-A(4, 5-HT3A-A(6, and 5-HT3A-A(7 were similar to WT. In contrast, 5-HT3A-A(3 and 5-HT3A-A(5 had desensitization rates at least an order of magnitude faster than WT. The one Ala loop construct, 5-HT3A-A(1, entered a non-functional state from which it did not recover after the first 5-HT application. These results suggest that the large M3M4 loop of eukaryotic Cys-loop channels is not required for receptor assembly or function. However, loop length and amino acid composition can effect channel expression and desensitization. We infer that the cytoplasmic ends of the M3 and M4 segments may undergo conformational changes during channel gating and desensitization and/or the loop may influence the position and mobility of these segments as they undergo gating-induced conformational changes. Altering structure or conformational mobility of the cytoplasmic ends of M3 and M4 may be the basis by which phosphorylation or protein binding to the cytoplasmic loop alters channel function.

  8. Binding properties of nine 4-diphenyl-acetoxy-N-methyl-piperidine (4-DAMP) analogues to M1, M2, M3 and putative M4 muscarinic receptor subtypes.

    OpenAIRE

    Waelbroeck, M.; Camus, J.; Tastenoy, M.; Christophe, J.

    1992-01-01

    1. We compared the binding properties of 4-diphenyl-acetoxy-N-methyl-piperidine methiodide (4-DAMP) and nine analogues of this compound on muscarinic receptors of human neuroblastoma NB-OK1 cells (M1 subtype), rat heart (M2 subtype), rat pancreas (M3 subtype) and to the putative M4 subtype in striatum. 2. The requirements for high affinity binding were somewhat different for the four receptor subtypes. In general, the requirements of M3 receptors were more stringent than for M1, M2 or putativ...

  9. Hammurabi and the Electronic Age: Documenting Electronic Collecting Decisions.

    Science.gov (United States)

    Fedunok, Suzanne

    1996-01-01

    Presents a list of commonly used elements found in a number of electronic information collection development policy statements collected by an American Library Association committee. The article concludes with a selected annotated bibliography of 14 sources relating to collection development policies for electronic information resources.…

  10. 研究/電子資源使用統計標準與規範之探討/陳雪華;許嘉珍;朱雅琦 | Study of the Electronic Resources Usage Statistics Standards and Guidelines/ Hsueh-Hua Chen;Chia-Chen Hsu;Ya-Chi Chu

    Directory of Open Access Journals (Sweden)

    陳雪華、許嘉珍、朱雅琦

    2007-04-01

    Full Text Available

    近年來,由於資訊科技的進步,圖書館中的電子資源數量快速增加,所佔預算金額比例也大幅增長。圖書館希望能夠透過評鑑電子資源的使用,以便能夠在電 子資源館藏發展等方面做出正確的決策。由於體認到電子資源使用統計之重要性,圖書館界與相關組織紛紛發展或修訂圖書館統計標準,增列電子資源使用統計的項 目以充分反映圖書館電子資源使用之狀況。本文主要採用文獻分析法以及內容分析法,收集探討並比較近軍來國內外電子資源使用統計之相關規範及標準,包含 ISO 2789、 ICOLC Guidelines、州ANSI/NISO Z39.7、CNS13151、ARL E-Metrlcs、E-Measures Project、以及Project COUNTER等。

    Recently, due to the advances of information technology, electronic resources are gradually replacing print resources as the largest consumer of library acquisition budgets. Logically, libraries want to evaluate the usage of electronic resources and incorporate the results into their decision making regarding electronic resource acquisition. Over these years, there is a general awareness among libraries to develop statistics standards and guidelines for library electronic resources usage. In this paper, literature review and content analysis methods are used to compare several library statistics standards, including: ISO 2789 、ICOLC Guidelines、ANSI/NISO Z39.7、CNS13151、ARL E-Metrics、E-Measures Project、and Project COUNTER etc.

    頁次:89-102

  11. Oxylipin biosynthesis in spikemoss Selaginella moellendorffii: Molecular cloning and identification of divinyl ether synthases CYP74M1 and CYP74M3.

    Science.gov (United States)

    Gorina, Svetlana S; Toporkova, Yana Y; Mukhtarova, Lucia S; Smirnova, Elena O; Chechetkin, Ivan R; Khairutdinov, Bulat I; Gogolev, Yuri V; Grechkin, Alexander N

    2016-04-01

    Nonclassical P450s of CYP74 family control the secondary conversions of fatty acid hydroperoxides to bioactive oxylipins in plants. At least ten genes attributed to four novel CYP74 subfamilies have been revealed by the recent sequencing of the spikemoss Selaginella moellendorffii Hieron genome. Two of these genes CYP74M1 and CYP74M3 have been cloned in the present study. Both recombinant proteins CYP74M1 and CYP74M3 were active towards the 13(S)-hydroperoxides of α-linolenic and linoleic acids (13-HPOT and 13-HPOD, respectively) and exhibited the activity of divinyl ether synthase (DES). Products were analyzed by gas chromatography-mass spectrometry. Individual oxylipins were purified by HPLC and finally identified by their NMR data, including the (1)H NMR, 2D-COSY, HSQC and HMBC. CYP74M1 (SmDES1) specifically converted 13-HPOT to (11Z)-etherolenic acid and 13-HPOD to (11Z)-etheroleic acid. CYP74M3 (SmDES2) turned 13-HPOT and 13-HPOD mainly to etherolenic and etheroleic acids, respectively. CYP74M1 and CYP74M3 are the first DESs detected in non-flowering plants. The obtained results demonstrate the existence of the sophisticated oxylipin biosynthetic machinery in the oldest taxa of vascular plants.

  12. Maternal Malaria and Malnutrition (M3) initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western Pacific

    DEFF Research Database (Denmark)

    Unger, Holger W; Cates, Jordan E; Gutman, Julie

    2016-01-01

    PURPOSE: The Maternal Malaria and Malnutrition (M3) initiative has pooled together 13 studies with the hope of improving understanding of malaria-nutrition interactions during pregnancy and to foster collaboration between nutritionists and malariologists. PARTICIPANTS: Data were pooled on 14 635...

  13. Muscarinic acetylcholine receptor M1 and M3 subtypes mediate acetylcholine-induced endothelium-independent vasodilatation in rat mesenteric arteries.

    Science.gov (United States)

    Tangsucharit, Panot; Takatori, Shingo; Zamami, Yoshito; Goda, Mitsuhiro; Pakdeechote, Poungrat; Kawasaki, Hiromu; Takayama, Fusako

    2016-01-01

    The present study investigated pharmacological characterizations of muscarinic acetylcholine receptor (AChR) subtypes involving ACh-induced endothelium-independent vasodilatation in rat mesenteric arteries. Changes in perfusion pressure to periarterial nerve stimulation and ACh were measured before and after the perfusion of Krebs solution containing muscarinic receptor antagonists. Distributions of muscarinic AChR subtypes in mesenteric arteries with an intact endothelium were studied using Western blotting. The expression level of M1 and M3 was significantly greater than that of M2. Endothelium removal significantly decreased expression levels of M2 and M3, but not M1. In perfused mesenteric vascular beds with intact endothelium and active tone, exogenous ACh (1, 10, and 100 nmol) produced concentration-dependent and long-lasting vasodilatations. In endothelium-denuded preparations, relaxation to ACh (1 nmol) disappeared, but ACh at 10 and 100 nmol caused long-lasting vasodilatations, which were markedly blocked by the treatment of pirenzepine (M1 antagonist) or 4-DAMP (M1 and M3 antagonist) plus hexamethonium (nicotinic AChR antagonist), but not methoctramine (M2 and M4 antagonist). These results suggest that muscarinic AChR subtypes, mainly M1, distribute throughout the rat mesenteric arteries, and that activation of M1 and/or M3 which may be located on CGRPergic nerves releases CGRP, causing an endothelium-independent vasodilatation. Copyright © 2015 Japanese Pharmacological Society. Production and hosting by Elsevier B.V. All rights reserved.

  14. Muscarinic acetylcholine receptor M1 and M3 subtypes mediate acetylcholine-induced endothelium-independent vasodilatation in rat mesenteric arteries

    Directory of Open Access Journals (Sweden)

    Panot Tangsucharit

    2016-01-01

    Full Text Available The present study investigated pharmacological characterizations of muscarinic acetylcholine receptor (AChR subtypes involving ACh-induced endothelium-independent vasodilatation in rat mesenteric arteries. Changes in perfusion pressure to periarterial nerve stimulation and ACh were measured before and after the perfusion of Krebs solution containing muscarinic receptor antagonists. Distributions of muscarinic AChR subtypes in mesenteric arteries with an intact endothelium were studied using Western blotting. The expression level of M1 and M3 was significantly greater than that of M2. Endothelium removal significantly decreased expression levels of M2 and M3, but not M1. In perfused mesenteric vascular beds with intact endothelium and active tone, exogenous ACh (1, 10, and 100 nmol produced concentration-dependent and long-lasting vasodilatations. In endothelium-denuded preparations, relaxation to ACh (1 nmol disappeared, but ACh at 10 and 100 nmol caused long-lasting vasodilatations, which were markedly blocked by the treatment of pirenzepine (M1 antagonist or 4-DAMP (M1 and M3 antagonist plus hexamethonium (nicotinic AChR antagonist, but not methoctramine (M2 and M4 antagonist. These results suggest that muscarinic AChR subtypes, mainly M1, distribute throughout the rat mesenteric arteries, and that activation of M1 and/or M3 which may be located on CGRPergic nerves releases CGRP, causing an endothelium-independent vasodilatation.

  15. Maternal Malaria and Malnutrition (M3) initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western Pacific

    DEFF Research Database (Denmark)

    Unger, Holger W; Cates, Jordan E; Gutman, Julie;

    2016-01-01

    PURPOSE: The Maternal Malaria and Malnutrition (M3) initiative has pooled together 13 studies with the hope of improving understanding of malaria-nutrition interactions during pregnancy and to foster collaboration between nutritionists and malariologists. PARTICIPANTS: Data were pooled on 14 635...... and alternative or intensified malaria prevention regimens, and the settings in which these interventions would be most effective....

  16. The colon-selective spasmolytic otilonium bromide inhibits muscarinic M3 receptor-coupled calcium signals in isolated human colonic crypts

    Science.gov (United States)

    Lindqvist, Susanne; Hernon, James; Sharp, Paul; Johns, Neil; Addison, Sarah; Watson, Mark; Tighe, Richard; Greer, Shaun; Mackay, Jean; Rhodes, Michael; Lewis, Michael; Stebbings, William; Speakman, Chris; Evangelista, Stefano; Johnson, Ian; Williams, Mark

    2002-01-01

    Otilonium bromide (OB) is a smooth muscle relaxant used in the treatment of irritable bowel syndrome. Otilonium bromide has been shown to interfere with the mobilization of calcium in intestinal smooth muscle, but the effects on other intestinal tissues have not been investigated. We identified the muscarinic receptor subtype coupled to calcium signals in colonic crypt derived from the human colonic epithelium and evaluated the inhibitory effects of OB. Calcium signals were monitored by fluorescence imaging of isolated human colonic crypts and Chinese hamster ovary cells stably expressing the cloned human muscarinic M3 receptor subtype (CHO-M3). Colonic crypt receptor expression was investigated by pharmacological and immunohistochemical techniques. The secretagogue acetylcholine (ACh) stimulated calcium mobilization from intracellular calcium stores at the base of human colonic crypts with an EC50 of 14 μM. The muscarinic receptor antagonists 4-DAMP, AF-DX 384, pirenzepine and methroctamine inhibited the ACh-induced calcium signal with the following respective IC50 (pKb) values: 0.78 nM (9.1), 69 nM (7.2), 128 nM (7.1), and 2510 nM (5.8). Immunohistochemical analyses of muscarinic receptor expression demonstrated the presence of M3 receptor subtype expression at the crypt-base. Otilonium bromide inhibited the generation of ACh-induced calcium signals in a dose dependent manner (IC50=880 nM). In CHO-M3 cells, OB inhibited calcium signals induced by ACh, but not ATP. In addition, OB did not inhibit histamine-induced colonic crypt calcium signals. The present studies have demonstrated that OB inhibited M3 receptor-coupled calcium signals in human colonic crypts and CHO-M3 cells, but not those induced by stimulation of other endogenous receptor types. We propose that the M3 receptor-coupled calcium signalling pathway is directly targeted by OB at the level of the colonic epithelium, suggestive of an anti-secretory action in IBS patients suffering with diarrhoea. PMID

  17. The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts.

    Science.gov (United States)

    Lindqvist, Susanne; Hernon, James; Sharp, Paul; Johns, Neil; Addison, Sarah; Watson, Mark; Tighe, Richard; Greer, Shaun; Mackay, Jean; Rhodes, Michael; Lewis, Michael; Stebbings, William; Speakman, Chris; Evangelista, Stefano; Johnson, Ian; Williams, Mark

    2002-12-01

    1. Otilonium bromide (OB) is a smooth muscle relaxant used in the treatment of irritable bowel syndrome. Otilonium bromide has been shown to interfere with the mobilization of calcium in intestinal smooth muscle, but the effects on other intestinal tissues have not been investigated. We identified the muscarinic receptor subtype coupled to calcium signals in colonic crypt derived from the human colonic epithelium and evaluated the inhibitory effects of OB. 2. Calcium signals were monitored by fluorescence imaging of isolated human colonic crypts and Chinese hamster ovary cells stably expressing the cloned human muscarinic M(3) receptor subtype (CHO-M(3)). Colonic crypt receptor expression was investigated by pharmacological and immunohistochemical techniques. 3. The secretagogue acetylcholine (ACh) stimulated calcium mobilization from intracellular calcium stores at the base of human colonic crypts with an EC(50) of 14 micro M. The muscarinic receptor antagonists 4-DAMP, AF-DX 384, pirenzepine and methroctamine inhibited the ACh-induced calcium signal with the following respective IC(50) (pK(b)) values: 0.78 nM (9.1), 69 nM (7.2), 128 nM (7.1), and 2510 nM (5.8). 4. Immunohistochemical analyses of muscarinic receptor expression demonstrated the presence of M(3) receptor subtype expression at the crypt-base. 5. Otilonium bromide inhibited the generation of ACh-induced calcium signals in a dose dependent manner (IC(50)=880 nM). 6. In CHO-M(3) cells, OB inhibited calcium signals induced by ACh, but not ATP. In addition, OB did not inhibit histamine-induced colonic crypt calcium signals. 7. The present studies have demonstrated that OB inhibited M(3) receptor-coupled calcium signals in human colonic crypts and CHO-M(3) cells, but not those induced by stimulation of other endogenous receptor types. We propose that the M(3) receptor-coupled calcium signalling pathway is directly targeted by OB at the level of the colonic epithelium, suggestive of an anti-secretory action

  18. Electronic Reference Works and Library Budgeting Dilemma

    Science.gov (United States)

    Lawal, Ibironke O.

    2007-01-01

    The number of electronic resources has climbed up steadily in recent times. Some of these e-resources are reference sources, mostly in Science, Technology and Medicine (STM), which publishers convert to electronic for obvious reasons. The library budgets for materials usually have two main lines, budget for one time purchase (monographs) and…

  19. Involvement of M3 Cholinergic Receptor Signal Transduction Pathway in Regulation of the Expression of Chemokine MOB-1, MCP-1 Genes in Pancreatic Acinar Cells

    Institute of Scientific and Technical Information of China (English)

    郑海; 陈道达; 张景輝; 田原

    2004-01-01

    Whether M3 cholinergic receptor signal transduction pathway is involved in regulation of the activation of NF-κB and the expression of chemokine MOB-1, MCP-1genes in pancreatic acinar cells was investigated. Rat pancreatic acinar cells were isolated, cultured and treated with carbachol, atropine and PDTC in vitro. The MOB-1 and MCP-1 mRNA expression was detected by using RT-PCR. The activation of NF-κB was monitored by using electrophoretic mobility shift assay.The results showed that as compared with control group, M3 cholinergic receptor agonist (103mol/L, 104-4ol/L carbachol) could induce a concentration-dependent and time-dependent increase in the expression of MOB-1, MCP-1 mRNA in pancreatic acinar cells. After treatment with 10 -3mol/L carbachol for 2 h, the expression of MOB-1, MCP-1 mRNA was strongest. The activity of NF-κB in pancreatic acinar cells was significantly increased (P<0.01) after treated with M3 cholinergic receptor agonist (10-3 mol/L carbachol) in vitro for 30 min. Either M3 cholinergic receptor antagonist (10-5 mol/L atropine) or NF-κB inhibitor (10-2 mol/L PDTC) could obviously inhibit the activation of NF-κB and the chemokine MOB-1, MCP-1 mRNA expression induced by carbachol (P <0.05). This inhibitory effect was significantly increased by atropine plus PDTC (P<0.01). The results of these studies indicated that M3 cholinergic receptor signal transduction pathway was likely involved in regulation of the expression of chemokine MOB-1 and MCP-1genes in pancreatic acinar cells in vitro through the activation of NF-κB.

  20. Ambient Electronics

    Science.gov (United States)

    Sekitani, Tsuyoshi; Someya, Takao

    2012-10-01

    We report the recent research progress and future prospects of flexible and printed electronics, focusing on molecular electronic material-based thin-film transistors, which are expected to usher in a new era of electronics.

  1. Electron cooling

    Science.gov (United States)

    Meshkov, I.; Sidorin, A.

    2004-10-01

    The brief review of the most significant and interesting achievements in electron cooling method, which took place during last two years, is presented. The description of the electron cooling facilities-storage rings and traps being in operation or under development-is given. The applications of the electron cooling method are considered. The following modern fields of the method development are discussed: crystalline beam formation, expansion into middle and high energy electron cooling (the Fermilab Recycler Electron Cooler, the BNL cooler-recuperator, cooling with circulating electron beam, the GSI project), electron cooling in traps, antihydrogen generation, electron cooling of positrons (the LEPTA project).

  2. Negotiating for Critical Resources.

    Science.gov (United States)

    Bartunek, Frank P.

    1994-01-01

    School districts dependent on outside resources must develop skills for securing educational resources, including competencies in collaborative, creative, and principled resource management. Constructive negotiations between local and provincial levels of government can improve relationships and support the development of collaborative…

  3. Recent development in thermally activated desalination methods: achieving an energy efficiency less than 2.5 kWhelec/m3

    KAUST Repository

    Shahzad, Muhammad Wakil

    2015-05-19

    Water-Energy-Environment nexus is a crucial consideration when designing seawater desalination processes, particularly for the water-stressed countries where the annual water availability is less than 250 m3 per capita. Despite the thermodynamics limit for seawater desalination at normal conditions is about 0.78 to 1.09 kWhelec/m3, the specific energy consumption of desalination of real plants is found to operate at several folds higher. Today’s technological advancement in membranes, namely the reverse osmosis processes, has set an energy consumption of around 3.5–5 kWhelec/m3, while the conventional perception of thermally activated processes such as MSF and MED tends to be higher. Although the higher energetic specific consumption of MED or MSF processes appeared to be higher at 60–100 kWhthermal/m3, their true electricity equivalent has been converted, hitherto, using the energetic analyses where the work potential of working steam of the processes cannot be captured adequately. Thermally activated processes, such as MED and MSF, form the bottoming cycle of a cogeneration plant where both electricity and desalination processes operate in tandem in a cascaded manner. Only the bled-steam at lower exergy is extracted for the desalination processes. In this presentation, we demonstrate that in a cogen plant with 30% bled-steam for MED processes, the exergy destruction ratio is found to be less than 7% of the total available exergy that emanated from the boilers. By the exergetic approach, the equivalent electricity consumption of an average 75 kWhthermal/m3 would result in an electrical equivalent of less than 2.5 kWhelec/m3. Also in this presentation, the authors will elaborate the latest developments in the use of hybridization concept where the MED and the AD cycles are thermodynamically integrated and enhancing the overall efficiency of desalination. © 2015 Balaban Desalination Publications. All rights reserved.

  4. Digital Knowledge Resources Sharing Through Online Distance Education Course

    Institute of Scientific and Technical Information of China (English)

    Josephine; Yu; Chen; Sche

    2002-01-01

    Since the electronic resources and Internet Web sites became popular, distance education courses offered via the Internet could play an important role in providing global digital resources and teaching the knowledge of international library and information standards for bibliographic databases with electronic and web resources.This paper uses the example of the author's new online course: ILS 608 Cataloging and Development of a Digital Union Catalog for Ancient Chinese Books to demonstrate the global re...

  5. Mother Lode: The Untapped Rare Earth Mineral Resources of Vietnam

    Science.gov (United States)

    2013-11-01

    hundreds of Bq/m 3 of air; the recommended safety limits for civilian exposure are 3.5 mSv/year and 0.15 Bq/m 3 , respectively. 37 REO Mining – a...Commission for Asia and the Pacific. Atlas of Mineral Resources of the ESCAP Region, Vol. 6, Viet Nam. ST/ESCAP/831. Bangkok : UNESCAP, 1990. “US$ 35.5... Bangkok ), July 19, 2013. ProQuest (1400734925). “VINACOMIN and Japanese Firm to Exploit and Process Rare Earth in Lai Chau.” Vietnam National

  6. Towards a liquid Argon TPC without evacuation filling of a 6$m^3$ vessel with argon gas from air to ppm impurities concentration through flushing

    CERN Document Server

    Curioni, A; Gendotti, A; Knecht, L; Lussi, D; Marchionni, A; Natterer, G; Resnati, F; Rubbia, A; Coleman, J; Lewis, M; Mavrokoridis, K; McCormick, K; Touramanis, C

    2010-01-01

    In this paper we present a successful experimental test of filling a volume of 6 $m^3$ with argon gas, starting from normal ambient air and reducing the impurities content down to few parts per million (ppm) oxygen equivalent. This level of contamination was directly monitored measuring the slow component of the scintillation light of the Ar gas, which is sensitive to $all$ sources of impurities affecting directly the argon scintillation.

  7. Sources and physical processes responsible for OH/H2O in the lunar soil as revealed by the Moon Mineralogy Mapper (M3)

    Science.gov (United States)

    McCord, T.B.; Taylor, L.A.; Combe, J.-P.; Kramer, G.; Pieters, C.M.; Sunshine, J.M.; Clark, R.N.

    2011-01-01

    Analysis of two absorption features near 3 m in the lunar reflectance spectrum, observed by the orbiting M3 spectrometer and interpreted as being due to OH and H2O, is presented, and the results are used to discuss the processes producing these molecules. This analysis focuses on the dependence of the absorptions on lunar physical properties, including composition, illumination, latitude, and temperature. Solar wind proton-induced hydroxylation is proposed as the creation process, and its products could be a source for other reported types of hydrogen-rich material and water. The irregular and damaged fine-grained lunar soil seems especially adapted for trapping solar wind protons and forming OH owing to abundant dangling oxygen bonds. The M3 data reveal that the strengths of the two absorptions are correlated and widespread, and both are correlated with lunar composition but in different ways. Feldspathic material seems richer in OH. These results seem to rule out water from the lunar interior and cometary infall as major sources. There appear to be correlations of apparent band strengths with time of day and lighting conditions. However, thermal emission from the Moon reduces the apparent strengths of the M3 absorptions, and its removal is not yet completely successful. Further, many of the lunar physical properties are themselves intercorrelated, and so separating these dependencies on the absorptions is difficult, due to the incomplete M3 data set. This process should also operate on other airless silicate surfaces, such as Mercury and Vesta, which will be visited by the Dawn spacecraft in mid-2011. Copyright 2011 by the American Geophysical Union.

  8. Virulence of two Streptococcus pyogenes strains (types M1 and M3) associated with toxic-shock-like syndrome depends on an intact mry-like gene.

    OpenAIRE

    Perez-Casal, J F; Dillon, H F; Husmann, L K; Graham, B.; Scott, J R

    1993-01-01

    The major virulence factor of Streptococcus pyogenes, the M protein, is positively regulated at the transcriptional level by mry in the M type 6 strain studied. We show here that in two S. pyogenes strains isolated from cases of toxic-shock-like syndrome, a type M1 strain and a type M3 strain, an mry-like gene is also required for resistance to phagocytosis.

  9. Comparison of Analysis Results Between 2D/1D Synthesis and RAPTOR-M3G in the Korea Standard Nuclear Plant (KSNP)

    Science.gov (United States)

    Joung Lim, Mi; Maeng, Young Jae; Fero, Arnold H.; Anderson, Stanwood L.

    2016-02-01

    The 2D/1D synthesis methodology has been used to calculate the fast neutron (E > 1.0 MeV) exposure to the beltline region of the reactor pressure vessel. This method uses the DORT 3.1 discrete ordinates code and the BUGLE-96 cross-section library based on ENDF/B-VI. RAPTOR-M3G (RApid Parallel Transport Of Radiation-Multiple 3D Geometries) which performs full 3D calculations was developed and is based on domain decomposition algorithms, where the spatial and angular domains are allocated and processed on multi-processor computer architecture. As compared to traditional single-processor applications, this approach reduces the computational load as well as the memory requirement per processor. Both methods are applied to surveillance test results for the Korea Standard Nuclear Plant (KSNP)-OPR (Optimized Power Reactor) 1000 MW. The objective of this paper is to compare the results of the KSNP surveillance program between 2D/1D synthesis and RAPTOR-M3G. Each operating KSNP has a reactor vessel surveillance program consisting of six surveillance capsules located between the core and the reactor vessel in the downcomer region near the reactor vessel wall. In addition to the In-Vessel surveillance program, an Ex-Vessel Neutron Dosimetry (EVND) program has been implemented. In order to estimate surveillance test results, cycle-specific forward transport calculations were performed by 2D/1D synthesis and by RAPTOR-M3G. The ratio between measured and calculated (M/C) reaction rates will be discussed. The current plan is to install an EVND system in all of the Korea PWRs including the new reactor type, APR (Advanced Power Reactor) 1400 MW. This work will play an important role in establishing a KSNP-specific database of surveillance test results and will employ RAPTOR-M3G for surveillance dosimetry location as well as positions in the KSNP reactor vessel.

  10. 肌肉白天使!——G—Power BMW M3(E92)GT2 R

    Institute of Scientific and Technical Information of China (English)

    斌志

    2013-01-01

    G-Power为德国老字号BMW改装商之一,推出了超暴力型的M3(E92)GT2R版本。雪白车漆配搭赛车拉花、20英寸黑色锻造轮毂、GT大尾翼以及全车碳纤宽体处理,横竖看都是暴力!!!

  11. RR Lyrae stars in the outer region of the globular cluster M3: a shortage of long periods at r ~ 3.5 to 6 arcmin ?

    CERN Document Server

    Butler, D J

    2004-01-01

    An analysis of the radial distribution of ab-type RR Lyrae star periods in the outer region of the globular cluster M3 at r >= 0.83 arcmin has been performed. That analysis points towards a real shortage of stars with long periods in the radial distance range 3.5 to 6 arcmin (or about 7 to 12 core radii). A brief discussion is presented. The origin of the phenomenon remains an open question.

  12. Sleep as spatiotemporal integration of biological processes that evolved to periodically reinforce neurodynamic and metabolic homeostasis: The 2m3d paradigm of sleep.

    Science.gov (United States)

    Mader, Edward Claro; Mader, Annie Cielo Llave

    2016-08-15

    Sleep continues to perplex scientists and researchers. Despite decades of sleep research, we still lack a clear understanding of the biological functions and evolution of sleep. In this review, we will examine sleep from a functional and phylogenetic perspective and describe some important conceptual gaps in understanding sleep. Classical theories of the biology and evolution of sleep emphasize sensory activation, energy balance, and metabolic homeostasis. Advances in electrophysiology, functional neuroimaging, and neuroplasticity allow us to view sleep within the framework of neural dynamics. With this paradigm shift, we have come to realize the importance of neurodynamic homeostasis in shaping the biology of sleep. Evidently, animals sleep to achieve neurodynamic and metabolic homeostasis. We are not aware of any framework for understanding sleep where neurodynamic, metabolic, homeostatic, chronophasic, and afferent variables are all taken into account. This motivated us to propose the two-mode three-drive (2m3d) paradigm of sleep. In the 2m3d paradigm, local neurodynamic/metabolic (N/M) processes switch between two modes-m0 and m1-in response to three drives-afferent, chronophasic, and homeostatic. The spatiotemporal integration of local m0/m1 operations gives rise to the global states of sleep and wakefulness. As a framework of evolution, the 2m3d paradigm allows us to view sleep as a robust adaptive strategy that evolved so animals can periodically reinforce neurodynamic and metabolic homeostasis while remaining sensitive to their internal and external environment.

  13. Describing the heavy-ion above-barrier fusion using the bare potentials resulting from Migdal and M3Y double-folding approaches

    Science.gov (United States)

    Gontchar, I. I.; Chushnyakova, M. V.

    2016-08-01

    Systematic calculations of the Coulomb barrier parameters for collisions of spherical nuclei are performed within the framework of the double folding approach. The value of the parameter {B}Z={Z}P{Z}T/({A}P{1/3}+{A}T{1/3}) (which estimates the Coulomb barrier height) varies in these calculations from 10 MeV up to 150 MeV. The nuclear densities came from the Hartree-Fock calculations which reproduce the experimental charge densities with good accuracy. For the nucleon-nucleon effective interaction two analytical approximations known in the literature are used: the M3Y and Migdal forces. The calculations show that Migdal interaction always results in the higher Coulomb barrier. Moreover, as B Z increases the difference between the M3Y and Migdal barrier heights systematically increases as well. As the result, the above barrier fusion cross sections calculated dynamically with the M3Y forces and surface friction are in agreement with the data. The cross sections calculated with the Migdal forces are always below the experimental data even without accounting for the dissipation.

  14. Describing the heavy-ion above-barrier fusion using the bare potentials resulting from Migdal and M3Y double-folding approaches

    CERN Document Server

    Gontchar, Igor

    2015-01-01

    Systematic calculations of the Coulomb barrier parameters for collisions of spherical nuclei are performed within the framework of the double folding approach. The value of the parameter $B_Z=Z_PZ_T/(A^{1/3}_P+(A^{1/3}_P)$ (which estimates the Coulomb barrier height) varies in these calculations from 10 MeV up to 150 MeV. The nuclear densities came from the Hartree-Fock calculations which reproduce the experimental charge densities with good accuracy. For the nucleon-nucleon effective interaction two analytical approximations known in the literature are used: the M3Y and Migdal forces. The calculations show that Migdal interaction always results in the higher Coulomb barrier. Moreover, as $B_Z$ increases the difference between the M3Y and Migdal barrier heights systematically increases as well. As the result, the above barrier fusion cross sections calculated dynamically with the M3Y forces and surface friction are in agreement with the data. The cross sections calculated with the Migdal forces are always bel...

  15. K3M3 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  16. Conventional transmission electron microscopy.

    Science.gov (United States)

    Winey, Mark; Meehl, Janet B; O'Toole, Eileen T; Giddings, Thomas H

    2014-02-01

    Researchers have used transmission electron microscopy (TEM) to make contributions to cell biology for well over 50 years, and TEM continues to be an important technology in our field. We briefly present for the neophyte the components of a TEM-based study, beginning with sample preparation through imaging of the samples. We point out the limitations of TEM and issues to be considered during experimental design. Advanced electron microscopy techniques are listed as well. Finally, we point potential new users of TEM to resources to help launch their project.

  17. The Global Resource Nexus

    NARCIS (Netherlands)

    Ridder, M. de; Duijne, F. van; Jong, S. de; Jones, J.; Luit, E. van; Bekkers, F.F.; Auping, W.

    2014-01-01

    Supply and demand of resources are connected in a complex way. This interconnectivity has been framed as the global resource nexus and can conceivebly include all types of resources. This study focus on the nexus of five essential natural resources: land, food, energy, water and minerals. Together t

  18. The New Resource File

    Science.gov (United States)

    Luck, Donald D.

    2011-01-01

    The development of the resource file is a common experience in teacher preparation programs. The author examines strategies for transforming what has been a project composed of physical resources to one emphasizing digital resources. Methods for finding, tagging, storing and retrieving resources are explored.

  19. DYNAMIC RESOURCES OF RIVER SEDIMENTS

    Institute of Scientific and Technical Information of China (English)

    George GERGOV; Tzviatka KARAGIOZOVA

    2005-01-01

    The currently enforced Bulgarian water legislation [the Water Act (1999),the Environmental Protection Act (2002),etc.] requires conducting special studies for accurate assessments of sand and gravel flux along the rivers,prior to the issue of the license for operation of the quarries,where they will be dredged. The activity of a quarry necessitates special investigations because of the large dimensions of the damages inflicted on the environment. Ours studies have shown that there are two types of river reaches,in which abstracion of sand and gravel is performed. The first one refers usually to the plain area river reaches. The other type is mountainous with high rate of sediment load,which consists of coarse solid matter. The "on-the-spot" study on the environmental impact of the sand and gravel dredging has revealed that in the area of the quarry the riverbed cuts into the alluvial sediments to about 6-7 m and this ditch has spread by attenuation at a distance of more than 25 km upstream. Downstream the pit the picture is replicated and at the 8th km a local scour on the riverbed,amounting to more than 1.80 - 2.00 m,has been measured near the foundation of a massive bridge in the centre of city of Plovdiv. Such assessments of dynamic resources of sand and gravel materials are expected to serve for the purposes of gradual limitation of this activity in river sections close to renewable resources. The amount of sediment load,which may be abstracted in the area of the Orizare quarry in Bulgaria on a yearly basis has been calculated as 6000 m3/a. It ensures that the resources will not be exhausted and irreversible distortion of the riverbed will be prevented. This is an environmentally safe limit.

  20. Knowledge and Natural Resources

    DEFF Research Database (Denmark)

    Bertelsen, Rasmus Gjedssø; Justinussen, Jens Christian Svabo

    2016-01-01

    Arctic economies are generally natural resource based economies, whether they are indigenous economies largely dependent on living on the land or industrialized economies depending on marine resources, mineral resources or fossil or renewable energy resources. However, the central role of knowledge...... on the Icelandic and Faroese experiences with marine resources and renewable energy resources in geothermal, hydro, tidal and wind power. Iceland and the Faroe Islands are selected because they are examples of very small Arctic societies, which particularly well illustrate how the combination of human capital...... and marine resources and renewable energy can contribute to socio-economic and political-constitutional development....