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Sample records for lytton albion caspar

  1. Chicxulub Impact Ejecta From Albion Island, Belize

    Science.gov (United States)

    Ocampo, A.; Pope, K.; Fischer, A.; Alvarez, W.; Fouke, B.; Webster, C.; Vega, F.; Smit, J.; Fritsche, A.; Claeys, P.

    1999-01-01

    Impact ejecta from the Albion Formation are exposed in northern Belize. The ejecta come from the outer portion of the continuous ejecta blanket of the Chicxulub crater, which is located 360 km to the northwest.

  2. The CASPAR finding aids

    OpenAIRE

    Meghini, Carlo; Avancini, Henry; Versienti, Loredana

    2011-01-01

    One of the CASPAR key components is the FIND Components, which is implementing the Finding Aids of OAIS. According to OAIS, FIND manages Description Information that is associated to Information Packages in order to support the discovery of those Packages. FIND allows defining, creating, persisting, querying, browsing, and accessing both Description Information and the association between Information Packages and Description Information

  3. CASPAR - Nuclear Astrophysics Underground

    Science.gov (United States)

    Strieder, Frank; Robertson, Daniel; Couder, Manoel; Greife, Uwe; Wells, Doug; Wiescher, Michael

    2015-10-01

    The work of the LUNA Collaboration at the Laboratori Nationali del Gran Sasso demonstrated the research potential of an underground accelerator for the field of nuclear astrophysics. Several key reactions could be studied at LUNA, some directly at the Gamow peak for solar hydrogen burning. The CASPAR (Compact Accelerator System for Performing Astrophysical Research) Collaboration will implement a high intensity 1 MV accelerator at the Sanford Underground Research Facility (SURF) and overcome the current limitation at LUNA. The installation of the accelerator in the recently rehabilitated underground cavity at SURF started in Summer 2015 and first beam should be delivered by the end of the year. This project will primarily focus on the neutron sources for the s-process, e.g. 13C(α , n) 16O and 22Ne(α , n) 25Mg , and lead to unprecedented measurements compared to previous studies. A detailed overview of the science goals of CASPAR will be presented.

  4. Lytton Strachey : l’historien intime de deux reines Lytton Strachey’s Intimate Biographies of Two Queens

    Directory of Open Access Journals (Sweden)

    Jeannine Hayat

    2007-01-01

    Full Text Available The British writer Lytton Strachey (1880-1932 wrote biographies of the two most eminent Queens of England: Queen Victoria (1921 and Elizabeth and Essex (1928. The two books made him a very famous historian. However, he would personally have preferred to be admired for his poetry or his plays, for he was a very gifted literary author. Nevertheless many of Strachey’s readers have appreciated his conception of biography, as a means of personal confession while studying the destiny of a public figure. Indeed the Stracheyan way of life, free from Victorian moral standards and guided by the rules of the Bloomsbury group, inspired his story of Victoria and Elizabeth. Both Queens at the end of their lives and at the height of their power carried on strange love affairs: Victoria with her Scottish gillie and Elizabeth with the Earl of Essex, thirty years her younger. In fact, both romances subtly reflect Strachey’s own love affairs. He was himself engaged in a kind of common life with Dora Carrington— the painter, thirteen years younger than him, with whom he was not sexually involved— while he engaged in numerous homosexual love affairs.

  5. 33 CFR 80.1146 - Albion River, CA.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Albion River, CA. 80.1146 Section 80.1146 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1146 Albion River, CA. A line drawn on an...

  6. The CASPAR Approach to Digital Preservation

    Directory of Open Access Journals (Sweden)

    David Giaretta

    2007-07-01

    Full Text Available A description of some of the fundamental concepts in CASPAR as well as the metrics by which CASPAR believes that it, and other projects which claim to aid the practice of digital preservation, should be judged.

  7. Historikeren Caspar Paludan-Müller

    DEFF Research Database (Denmark)

    Møller, Jes Fabricius; Mordhorst, Mads

    Om historikeren Caspar Paludan-Müller's forfatterskab (1805-1882) og historismens udvikling og indflydelse i Danmark......Om historikeren Caspar Paludan-Müller's forfatterskab (1805-1882) og historismens udvikling og indflydelse i Danmark...

  8. [Caspar Bauhin (1560-1624)].

    Science.gov (United States)

    Bergmann, M; Wendler, D

    1986-01-01

    The paper describes the life and scientific work of Caspar Bauhin, whose 425th anniversary of his birth is in 1985. He is well-known in anatomy and botany and some species of plants are called after him. In anatomy his name is linked with the ileocaecal valve, though he apparently did not discover it. Especially Bauhin was engaged in improvement of anatomical and botanical nomenclature.

  9. A Lady 'in Proper Proportions'? Feminism, Lytton Strachey, and Florence Nightingale's Reputation, 1918-39.

    Science.gov (United States)

    Southern, James

    2017-03-01

    Lytton Strachey's Eminent Victorians has long been regarded as a watershed in attitudes to Victorian culture, widely seen as having instigated a revolutionary backlash against the values and heroes of the Victorian era in England. Its impact, however, on the reputations of his four subjects-Thomas Arnold, General Gordon, Cardinal Manning and Florence Nightingale-has been subjected to surprisingly little scholarly attention. Drawing on the work of gender historians, this article reassesses Strachey's effect on the reputation of Nightingale, using biographies and contemporary reviews of Eminent Victorians. It argues that, far from 'debunking' the famous nurse as is generally assumed, Strachey in many ways enhanced her reputation and rendered her a plausible icon for English feminists of the 1920s and 1930s. © The Author [2016]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  10. Caspar Stromayr: sixteenth century ophthalmologist.

    Science.gov (United States)

    Blanchard, D L

    1990-01-01

    Caspar Stromayr, ophthalmologist and hernia surgeon, is credited with writing the first German ophthalmic work of known authorship. Written in about 1559 as an appendix to Practica Copiosa, a larger work on hernia surgery, the ophthalmic chapters describe Stromayr's thoughts on the etiology and treatment of cataract. Stromayr, a master craftsman, also expresses his hostility to the shams and ignorance of the charlatan eye surgeons of his day. This interesting historical article provides a biographical sketch of Stromayr, a description of his book, and a translation of two chapters, "On Cataract of the Eye: How They Take Their Beginning and Whence they Come" and "How You Recognize the Cataract, When It is Ripe to Recline or to be Taken Away."

  11. CASPAR: User's guide. Version 1. 0. CASPAR: Anvaendarhandbok. Version 1. 0

    Energy Technology Data Exchange (ETDEWEB)

    Melin, L.; Westman, S.; Sundstroem, S.; Holmstroem, H.; Ericsson, J.

    1994-05-01

    CASPAR is a tool for studies, decision support and education in the field of protection against Chemical Warfare (CW) agents. CASPAR can be used for simulating air raids or artillery fire with CW agents. Output consists of alarm pattern, primary cloud data, persistent time, concentration and dosage areas, ground contamination, casualties etc. The casualties are calculated with regard to the personel protective equipment and combat activity. The results from the simulation are shown graphically on digital maps. The ground zero and the place for casualty calculation are determined by choosing a point on the map. The results can also be shown as tables and diagrams. In the computer program Military unit data base which is made available from CASPAR, the user can create data bases with different types of units and deployment places. The information in a data base can be plotted on digital maps and casualties can be calculated both for units and deployment places. Units can be moved directly on the map by using the mouse. CASPAR runs in Microsoft Windows environment on PC as well as the map presentation system MilPres II.

  12. Caspar, a suppressor of antibacterial immunity in Drosophila.

    Science.gov (United States)

    Kim, Myungjin; Lee, Jun Hee; Lee, Soo Young; Kim, Eunhee; Chung, Jongkyeong

    2006-10-31

    Drosophila has a primitive yet highly effective innate immune system. Although the infection-dependent activation mechanisms of the Drosophila immune system are well understood, its inhibitory regulation remains elusive. To find novel suppressors of the immune system, we performed a genetic screening for Drosophila mutants with hyperactivated immune responses and isolated a loss-of-function mutant of caspar whose product is homologous to Fas-associating factor 1 in mammals. Interestingly, caspar mutant flies showed increased antibacterial immune responses including increased resistance to bacterial infection and a constitutive expression of diptericin, a representative antibacterial peptide gene. Conversely, ectopic expression of caspar strongly suppressed the infection-dependent gene expression of diptericin, which allowed bacterial outgrowth. Consistent with these physiological phenotypes, Caspar negatively regulated the immune deficiency (Imd)-mediated immune responses by blocking nuclear translocation of Relish, an NF-kappaB transcription factor. In addition, we further demonstrated that Dredd-dependent cleavage of Relish, a prerequisite event for the nuclear entry of Relish, is the target of the Caspar-mediated suppression of the Imd pathway. Remarkably, Caspar was highly specific for the Imd pathway and did not affect the Toll pathway, which is crucial for antifungal immunity. Collectively, our elucidation of an inhibitory mechanism of the Imd pathway by Caspar will provide a valuable insight into understanding complex regulatory mechanisms of the innate immune systems in both Drosophila and mammals.

  13. Evaluation of the CASPAR alcohol education curriculum.

    Science.gov (United States)

    DiCicco, L; Biron, R; Carifio, J; Deutsch, C; Mills, D J; Orenstein, A; Re, A; Unterberger, H; White, R E

    1984-03-01

    The CASPAR education-prevention program was initiated when experimental results indicated that a 5-hr alcohol education curriculum at a Catholic high school was able to reduce frequent intoxication among teenagers. Attempts to institutionalize such a program in the public schools shows that (1) alcohol education can generate widespread community and school support; (2) workshops can successfully train teachers to adopt a decision-making approach, though close supervision is needed to ensure that this approach is adhered to in classroom teaching; (3) the CASPAR model of alcohol education produces classroom situations conducive to many children feeling free to express alcohol-related concerns; (4) trained teachers can serve as intermediaries between students with alcohol-related concerns and community resources, in particular those resources that are designed to help children from families with alcoholism; (5) the CASPAR curriculum, implemented by trained teachers, produces statistically significant knowledge and attitude gains, whereas alternate programs such as a special-events approach produce smaller knowledge gains and little attitude change; and (6) to a considerable extent, knowledge and attitude gains persist over time, although retention is greater on knowledge items and among older students. The results suggest that there may be a behavioral impact of instruction in the form of reduced alcohol misuse among teenagers, although if there is, it requires intensive and repeated exposure and can be demonstrated in these data only among younger students while they remain in junior high school. Although such results may be viewed as less supportive than the original experiment with which this work began, they do suggest that alcohol education remains an effective prevention strategy.

  14. Underground nuclear astrophysics studies with CASPAR

    Directory of Open Access Journals (Sweden)

    Robertson Daniel

    2016-01-01

    Full Text Available The drive of low-energy nuclear astrophysics laboratories is to study the reactions of importance to stellar burning processes and elemental production through stellar nucleosynthesis, over the energy range of astrophysical interest. As laboratory measurements approach the stellar burning window, the rapid drop off of cross-sections is a significant barrier and drives the need to lower background interference. The natural background suppression of underground accelerator facilities enables the extension of current experimental data to lower energies. An example of such reactions of interest are those thought to be sources of neutrons for the s-process, the major production mechanism for elements above the iron peak. The reactions 13C(α,n16O and 22Ne(α,n25Mg are the proposed initial focus of the new nuclear astrophysics accelerator laboratory (CASPAR currently under construction at the Sanford Underground Research Facility, Lead, South Dakota

  15. Underground nuclear astrophysics studies with CASPAR

    Science.gov (United States)

    Robertson, Daniel; Couder, Manoel; Greife, Uwe; Strieder, Frank; Wiescher, Michael

    2016-02-01

    The drive of low-energy nuclear astrophysics laboratories is to study the reactions of importance to stellar burning processes and elemental production through stellar nucleosynthesis, over the energy range of astrophysical interest. As laboratory measurements approach the stellar burning window, the rapid drop off of cross-sections is a significant barrier and drives the need to lower background interference. The natural background suppression of underground accelerator facilities enables the extension of current experimental data to lower energies. An example of such reactions of interest are those thought to be sources of neutrons for the s-process, the major production mechanism for elements above the iron peak. The reactions 13C(α,n)16O and 22Ne(α,n)25Mg are the proposed initial focus of the new nuclear astrophysics accelerator laboratory (CASPAR) currently under construction at the Sanford Underground Research Facility, Lead, South Dakota

  16. Anterior cervical fusion and Caspar plate stabilization for cervical trauma.

    Science.gov (United States)

    Caspar, W; Barbier, D D; Klara, P M

    1989-10-01

    A technique for anterior cervical iliac graft fusion with standardized, commercially available screw and plate fixation (Caspar plating) has been developed. The step-by-step procedure, as well as the instruments designed to facilitate the procedure, are described in this report. Sixty cases of cervical trauma (fractures, subluxations, ligamentous instability, or a combination of these problems) were treated with Caspar plating. All patients obtained fusion, and stability was achieved immediately after surgery without external stabilization. No unusual surgical complications occurred, and the most dreaded complication of dural penetration by drilling or screw placement was not observed. This report details the neurological presentation, anatomical lesions, surgical therapy, and outcome of these patients. Caspar plating combines the advantage of an anterior surgical approach with immediate postoperative stabilization without external stabilization. This advantage persists even in the presence of posterior ligamentous instability. The technique is an important addition to the surgical treatment of cervical trauma.

  17. The Compact Accelerator System for Performing Astrophysical Research Underground - CASPAR

    Science.gov (United States)

    Robertson, Daniel; Couder, Manoel; Greife, Uwe; Wells, Doug; Wiescher, Michael

    2014-03-01

    An accelerator laboratory (CASPAR) to be installed at the Sanford Underground Research Facility (SURF) is being constructed by a collaboration lead by South Dakota School of Mines and Technology. The study of alpha induced reactions of astrophysical interest in a quasi-background free environment is the goal of the laboratory. Specifically, neutron producing reactions for the s-process will be investigated. This process is responsible for the nucleosynthesis of half of the the elements heavier than iron. An outline of CASPAR, its timeline and scientific goals will be presented.

  18. Caspar Wessel. On the Analytical Representation of Direction

    DEFF Research Database (Denmark)

    This book contains the first complete English translation of Caspar Wessel's paper from 1797 "On the Analytical Representation of Direction". The paper has become famous because it gives the first geometric interpretation of the complex numbers. As the complete translation will show, it is also...... remarkable for the analytical representation of directions (vectors) in space and the elegant analytic solution of plane and spherical polygons. Wessel's essay is prefaced by two historical papers on the person Caspar Wessel and his work. They shed much new light on this first important Norwegian...

  19. Underground Nuclear Astrophysics - from LUNA to CASPAR

    Science.gov (United States)

    Strieder, Frank; Caspar Collaboration

    2015-04-01

    It is in the nature of astrophysics that many of the processes and objects are physically inaccessible. Thus, it is important that those aspects that can be studied in the laboratory are well understood. Nuclear reactions are such quantities that can be partly measured in the laboratory. These reactions influence the nucleosynthesis of the elements in the Big Bang as well as in all objects formed thereafter, and control the associated energy generation and evolution of stars. Since 20 years LUNA (Laboratory for Underground Nuclear Astrophysics) has been measuring cross sections relevant for hydrogen burning in the Gran Sasso Laboratory and demonstrated the research potential of an underground accelerator facility. Unfortunately, the number of reactions is limited by the energy range accessible with the 400 kV LUNA accelerator. The CASPAR (Compact Accelerator System for Performing Astrophysical Research) Collaboration will implement a high intensity 1 MV accelerator at the Sanford Underground Research Facility (SURF) and overcome the current limitation at LUNA. This project will primarily focus on the neutron sources for the so-called s-process, e.g. 13 C(α , n) 16 O and 22 Ne(α , n) 25 Mg , and lead to unprecedented measurements compared to previous studies.

  20. Advancing Underground Nuclear Astrophysics with CASPAR

    Science.gov (United States)

    Robertson, Daniel; Couder, Manoel; Greife, Uwe; Strieder, Frank; Wells, Doug; Wiescher, Michael

    2015-04-01

    The advancement of experimental nuclear astrophysics techniques and the requirement of astrophysical network models for further nuclear data over greater energy ranges, has led to the requirement for the better understanding of nuclear reactions in stellar burning regimes. For those reactions of importance to stellar burning processes and elemental production through stellar nucleosynthesis, the energy range of astrophysical interest is always problematic to probe. As reaction measurements approach the burning window of interest, the rapid drop off in cross-section hampers laboratory investigation. The natural background suppression of underground accelerator facilities enables the extension of current experimental data to lower energies. An example of such reactions of interest are those thought to be sources of neutrons for the s-process, the major production mechanism for elements above the iron peak. The reactions 13 C(α,n)16 O and 22 Ne(α,n)25 Mg are the proposed initial focus of the new nuclear astrophysics accelerator laboratory (CASPAR) currently under construction at the Sanford Underground Research Facility, Lead, SD. With thanks to funding provided by South Dakota Science and Technology Authority and the NSF under Grant Number PHY-1419765.

  1. Looking at Low-Background Nuclear Astrophysics Measurements using CASPAR

    Science.gov (United States)

    Robertson, Daniel; Couder, Manoel; Griefe, Uwe; Jung, Hyo Soon; Setoodehnia, Kiana; Wiescher, Michael; Wells, Doug; Caspar Collaboration

    2014-09-01

    An accelerator laboratory (CASPAR) to be installed at the Sanford Underground Research Facility (SURF) is being constructed by a collaboration lead by South Dakota School of Mines and Technology. The study of alpha induced reactions of astrophysical interest in a quasi-background free environment is the goal of the laboratory. Specifically, neutron producing reactions for the s-process will be investigated. This process is responsible for the nucleosynthesis of half of the elements heavier than iron. An outline of CASPAR, its timeline and scientific goals will be presented. An accelerator laboratory (CASPAR) to be installed at the Sanford Underground Research Facility (SURF) is being constructed by a collaboration lead by South Dakota School of Mines and Technology. The study of alpha induced reactions of astrophysical interest in a quasi-background free environment is the goal of the laboratory. Specifically, neutron producing reactions for the s-process will be investigated. This process is responsible for the nucleosynthesis of half of the elements heavier than iron. An outline of CASPAR, its timeline and scientific goals will be presented. Funding provided by SDSTA.

  2. Caspar Wessel (1745-1818). Surveyor and Mathematician

    DEFF Research Database (Denmark)

    Branner, Bodil; Johansen, Nils Voje

    1999-01-01

    This is a biography. It focus on Caspar Wessel's work as surveyor under the auspices of the Royal Danish Academy of Sciences and Letters, in particular on some of his theoretical investigations of geodesy that lead him to use complex numbers to represent directions in a plane at least as early...

  3. [Use and application in clinical practice of the CASPAR criteria].

    Science.gov (United States)

    Torre Alonso, Juan Carlos

    2010-03-01

    Several classification criteria for psoriatic arthritis have been proposed in the literature but it is still unclear which one of them best represents the diseases' ample spectrum. None of these classification criteria have been universally accepted. New classification criteria (CASPAR) have been recently published. Their application is simple, fast and easy to perform. In addition, they show two important qualities. One is that they allow for the diagnosis of psoriatic arthritis even when there is no skin disease present at the moment of diagnosis. The other is is that it enables us to classify a patient as having psoriatic arthritis in spite of a positive rheumatoid factor. The CASPAR criteria have a sensitivity of 91.4% and a specificity of 98.7%. It seems, in contrast, that it is not as high for recent-onset psoriatic arthritis. Therefore establishing the definition of inflammatory arthritis becomes paramount.

  4. Caspar controls resistance to Plasmodium falciparum in diverse anopheline species.

    OpenAIRE

    Garver, Lindsey S.; Yuemei Dong; George Dimopoulos

    2009-01-01

    Immune responses mounted by the malaria vector Anopheles gambiae are largely regulated by the Toll and Imd (immune deficiency) pathways via the NF-kappaB transcription factors Rel1 and Rel2, which are controlled by the negative regulators Cactus and Caspar, respectively. Rel1- and Rel2-dependent transcription in A. gambiae has been shown to be particularly critical to the mosquito's ability to manage infection with the rodent malaria parasite Plasmodium berghei. Using RNA interference to depl...

  5. Caspar plate fixation for the treatment of complex hangman's fractures.

    Science.gov (United States)

    Tuite, G F; Papadopoulos, S M; Sonntag, V K

    1992-05-01

    This report details our recent experience with the surgical treatment of complex hangman's fractures after failure of closed reduction and immobilization in external orthosis. We have successfully treated hangman's fractures in 5 patients with anterior Caspar plate stabilization and C2-C3 interbody fusion. The specific anatomical features of these fractures were complex, rendering the spines of the patients highly unstable. The patients were considered surgical candidates when reduction could not be achieved or maintained with axial traction or halo immobilization. Each patient underwent anterior C2-C3 interbody bone fusion and Caspar plating from C2 to C3. All patients achieved adequate intraoperative reduction and were immobilized postoperatively with a halo vest. The follow-up period ranged from 3 to 28 months and provided a 100% fusion rate with no complications related to plating or nonunion. Our initial experience indicates that anterior C2-C3 interbody bone fusion and Caspar plate fixation is a suitable treatment option for patients with complex hangman's fractures who are not successfully managed nonoperatively.

  6. Anterior cervical fusion with the Caspar instrumentation system.

    Science.gov (United States)

    Naito, M; Kurose, S; Oyama, M; Sugioka, Y

    1993-01-01

    We reviewed 106 consecutive patients who had undergone anterior cervical fusion with the Caspar instrumentation system between 1984 and 1989. Preoperative diagnoses were cervical spondylosis in 73 patients, a traumatic lesion in 12, ossification of the posterior longitudinal ligament in 9, cervical disc herniation in 6, and tumour or miscellaneous lesions in 6. In the 106 patients, 56 had two levels fused and 27 had three levels fused. At an average duration of follow-up of 4 years and 7 months, nonunion occurred in 3 of the 83 patients with multiple level fusions. Screw loosening occurred in 8 of the 106 patients, but there was no oesophageal perforation.

  7. Evolutionary analysis of the CACTA DNA-transposon Caspar across wheat species using sequence comparison and in situ hybridization.

    Science.gov (United States)

    Sergeeva, Ekaterina M; Salina, Elena A; Adonina, Irina G; Chalhoub, Boulos

    2010-07-01

    Mobile elements constitute a considerable part of the eukaryotic genome. This work is focused on the distribution and evolution of DNA-transposons in the genomes of diploid and allopolyploid Triticeae species and their role in the formation of functionally important chromosomal subtelomeric regions. The Caspar family is among the most abundant of CACTA DNA-transposons in Triticeae. To study the evolution of Caspar-like elements in Triticeae genomes, we analyzed their sequences and distribution in chromosomes by in situ hybridization. In total, 46 Caspar-like elements from the wheat and barley Caspar, Clifford, and Donald families were analyzed after being extracted from databases using the transposase consensus sequence. Sequence alignment and subsequent phylogenetic analyses revealed that the transposase DNA sequences formed three major distinct groups: (1) Clifford, (2) Caspar_Triticinae, and (3) Caspar_Hordeinae. Additionally, in situ hybridization demonstrated that Caspar_Triticinae transposons are predominantly compartmentalized in the subtelomeric chromosomal regions of wheat and its progenitors. Analysis of data suggested that compartmentalization in the subtelomeric chromosomal region was a characteristic feature of all the main groups of Caspar-like elements. Furthermore, a dot plot analysis of the terminal repeats demonstrated that the divergence of these repeats strictly correlated with the divergence of Caspar coding sequences. A clear distinction in the Caspar DNA sequences among the species Triticum/Aegilops (Caspar_Triticinae), Hordeum (Caspar_Hordeinae), and different distributions in individual hexaploid wheat genomes (A/B and D) suggest an independent proliferation of these elements in wheat (or its progenitors) and barley genomes. Thus, Caspar-like transposons can significantly contribute to the formation and differentiation of subtelomeric regions in Triticeae species.

  8. Caspar-like gene depletion reduces Leishmania infection in sand fly host Lutzomyia longipalpis.

    Science.gov (United States)

    Telleria, Erich L; Sant'Anna, Maurício R V; Ortigão-Farias, João R; Pitaluga, André N; Dillon, Viv M; Bates, Paul A; Traub-Csekö, Yara M; Dillon, Rod J

    2012-04-13

    Female phlebotomine sand flies Lutzomyia longipalpis naturally harbor populations of the medically important Leishmania infantum (syn. Leishmania chagasi) parasite in the gut, but the extent to which the parasite interacts with the immune system of the insect vector is unknown. To investigate the sand fly immune response and its interaction with the Leishmania parasite, we identified a homologue for caspar, a negative regulator of immune deficiency signaling pathway. We found that feeding antibiotics to adult female L. longipalpis resulted in an up-regulation of caspar expression relative to controls. caspar was differentially expressed when females were fed on gram-negative and gram-positive bacterial species. caspar expression was significantly down-regulated in females between 3 and 6 days after a blood feed containing Leishmania mexicana amastigotes. RNA interference was used to deplete caspar expression in female L. longipalpis, which were subsequently fed with Leishmania in a blood meal. Sand fly gut populations of both L. mexicana and L. infantum were significantly reduced in caspar-depleted females. The prevalence of L. infantum infection in the females fell from 85 to 45%. Our results provide the first insight into the operation of immune homeostasis in phlebotomine sand flies during the growth of bacterial and Leishmania populations in the digestive tract. We have demonstrated that the activation of the sand fly immune system, via depletion of a single gene, can lead to the abortion of Leishmania development and the disruption of transmission by the phlebotomine sand fly.

  9. Caspar-like Gene Depletion Reduces Leishmania Infection in Sand Fly Host Lutzomyia longipalpis*

    Science.gov (United States)

    Telleria, Erich L.; Sant'Anna, Maurício R. V.; Ortigão-Farias, João R.; Pitaluga, André N.; Dillon, Viv M.; Bates, Paul A.; Traub-Csekö, Yara M.; Dillon, Rod J.

    2012-01-01

    Female phlebotomine sand flies Lutzomyia longipalpis naturally harbor populations of the medically important Leishmania infantum (syn. Leishmania chagasi) parasite in the gut, but the extent to which the parasite interacts with the immune system of the insect vector is unknown. To investigate the sand fly immune response and its interaction with the Leishmania parasite, we identified a homologue for caspar, a negative regulator of immune deficiency signaling pathway. We found that feeding antibiotics to adult female L. longipalpis resulted in an up-regulation of caspar expression relative to controls. caspar was differentially expressed when females were fed on Gram-negative and Gram-positive bacterial species. caspar expression was significantly down-regulated in females between 3 and 6 days after a blood feed containing Leishmania mexicana amastigotes. RNA interference was used to deplete caspar expression in female L. longipalpis, which were subsequently fed with Leishmania in a blood meal. Sand fly gut populations of both L. mexicana and L. infantum were significantly reduced in caspar-depleted females. The prevalence of L. infantum infection in the females fell from 85 to 45%. Our results provide the first insight into the operation of immune homeostasis in phlebotomine sand flies during the growth of bacterial and Leishmania populations in the digestive tract. We have demonstrated that the activation of the sand fly immune system, via depletion of a single gene, can lead to the abortion of Leishmania development and the disruption of transmission by the phlebotomine sand fly. PMID:22375009

  10. Caspar controls resistance to Plasmodium falciparum in diverse anopheline species.

    Directory of Open Access Journals (Sweden)

    Lindsey S Garver

    2009-03-01

    Full Text Available Immune responses mounted by the malaria vector Anopheles gambiae are largely regulated by the Toll and Imd (immune deficiency pathways via the NF-kappaB transcription factors Rel1 and Rel2, which are controlled by the negative regulators Cactus and Caspar, respectively. Rel1- and Rel2-dependent transcription in A. gambiae has been shown to be particularly critical to the mosquito's ability to manage infection with the rodent malaria parasite Plasmodium berghei. Using RNA interference to deplete the negative regulators of these pathways, we found that Rel2 controls resistance of A. gambiae to the human malaria parasite Plasmodium falciparum, whereas Rel 1 activation reduced infection levels. The universal relevance of this defense system across Anopheles species was established by showing that caspar silencing also prevents the development of P. falciparum in the major malaria vectors of Asia and South America, A. stephensi and A. albimanus, respectively. Parallel studies suggest that while Imd pathway activation is most effective against P. falciparum, the Toll pathway is most efficient against P. berghei, highlighting a significant discrepancy between the human pathogen and its rodent model. High throughput gene expression analyses identified a plethora of genes regulated by the activation of the two Rel factors and revealed that the Toll pathway played a more diverse role in mosquito biology than the Imd pathway, which was more immunity-specific. Further analyses of key anti-Plasmodium factors suggest they may be responsible for the Imd pathway-mediated resistance phenotype. Additionally, we found that the fitness cost caused by Rel2 activation through caspar gene silencing was undetectable in sugar-fed, blood-fed, and P. falciparum-infected female A. gambiae, while activation of the Toll pathway's Rel1 had a major impact. This study describes for the first time a single gene that influences an immune mechanism that is able to abort

  11. Caspar controls resistance to Plasmodium falciparum in diverse anopheline species.

    Science.gov (United States)

    Garver, Lindsey S; Dong, Yuemei; Dimopoulos, George

    2009-03-01

    Immune responses mounted by the malaria vector Anopheles gambiae are largely regulated by the Toll and Imd (immune deficiency) pathways via the NF-kappaB transcription factors Rel1 and Rel2, which are controlled by the negative regulators Cactus and Caspar, respectively. Rel1- and Rel2-dependent transcription in A. gambiae has been shown to be particularly critical to the mosquito's ability to manage infection with the rodent malaria parasite Plasmodium berghei. Using RNA interference to deplete the negative regulators of these pathways, we found that Rel2 controls resistance of A. gambiae to the human malaria parasite Plasmodium falciparum, whereas Rel 1 activation reduced infection levels. The universal relevance of this defense system across Anopheles species was established by showing that caspar silencing also prevents the development of P. falciparum in the major malaria vectors of Asia and South America, A. stephensi and A. albimanus, respectively. Parallel studies suggest that while Imd pathway activation is most effective against P. falciparum, the Toll pathway is most efficient against P. berghei, highlighting a significant discrepancy between the human pathogen and its rodent model. High throughput gene expression analyses identified a plethora of genes regulated by the activation of the two Rel factors and revealed that the Toll pathway played a more diverse role in mosquito biology than the Imd pathway, which was more immunity-specific. Further analyses of key anti-Plasmodium factors suggest they may be responsible for the Imd pathway-mediated resistance phenotype. Additionally, we found that the fitness cost caused by Rel2 activation through caspar gene silencing was undetectable in sugar-fed, blood-fed, and P. falciparum-infected female A. gambiae, while activation of the Toll pathway's Rel1 had a major impact. This study describes for the first time a single gene that influences an immune mechanism that is able to abort development of P. falciparum

  12. [Surgeon and eye doctor Caspar Stromayr and the ophthalmological illustrations in his "Practica copiosa" (1559)].

    Science.gov (United States)

    Nover, A; Kümmel, W F

    1984-11-01

    In 1559 Caspar Stromayr wrote a richly illustrated book about hernias and their treatment. The manuscript also includes 3 chapters of a book on ophthalmological diseases which, however, was never published. In addition, it contains 6 separate watercolor illustrations of eye diseases, though without any explanatory texts. The authors attempt to interpret these first colored pictures of eye diseases.

  13. The CASPAR recoil discrimination detector for WIMP searches with calcium and fluorine.

    Science.gov (United States)

    Tovey, D. R.; Peak, C. D.; Roberts, J. W.; Spooner, N. J. C.

    1999-01-01

    The authors present results of development work on the CASPAR ('cocktail with alkali-halide scintillating particles') WIMP dark matter detector. The results of Monte Carlo simulations and neutron-scattering tests indicate that even a modest sized detector should provide improved spin-dependent WIMP sensitivity.

  14. The CASPAR recoil discrimination detector for WIMP searches with calcium and fluorine

    Energy Technology Data Exchange (ETDEWEB)

    Tovey, D.R.; Peak, C.D.; Roberts, J.W.; Spooner, N.J.C

    1999-01-01

    We present the results of development work on the CASPAR ('Cocktail with Alkali-halide Scintillating PARticles') WIMP Dark Matter detector. The results of Monte Carlo simulations and neutron-scattering tests indicate that even a modest sized detector should provide improved spin-dependent WIMP sensitivity.

  15. Biomechanical evaluation of Caspar cervical screws: comparative stability under cyclical loading.

    Science.gov (United States)

    Gallagher, M R; Maiman, D J; Reinartz, J; Pintar, F; Yoganandan, N

    1993-12-01

    Anterior cervical instrumentation is used as an adjunct to bone fusion; however, definitive biomechanical data to support some applications and techniques are lacking. In the absence of supportive experimental data, posterior cortical penetration has been recommended with the Caspar system. Previously, we compared the axial pull-out strength of Caspar screws with and without posterior cortical penetration. This study compares the stability of unicortical versus bicortical screw penetration groups under cyclical loading simulating physiological flexion-extension. Caspar screws were placed in human cadaveric vertebrae with or without posterior cortical purchase. Each screw was separately tested, simulating flexion-extension to 200 cycles. Deformation time data allowed a direct comparison of screw "wobble" with and without posterior cortical purchase. The mean deformation differences between subcortical and bicortical groups were statistically significant and increased over time within both groups. Enhanced stability was noted with bicortical purchase throughout most of the examined range, becoming more pronounced over longer periods of cyclical loading. Significant (P < 0.05) increases in deformation over time were noted for both groups, suggesting potentially significant deterioration at the screw-bone interface, despite bicortical purchase. Such deterioration with repeated flexion-extension loading may be of concern in the use of Caspar plates in the presence of multicolumn instability.

  16. Erosion Rates Over Millennial and Decadal Timescales: Measurements at Caspar Creek and Redwood Creek, Northern California

    Science.gov (United States)

    Ferrier, K. L.; Kirchner, J. W.; Finkel, R. C.

    2003-12-01

    Erosion rate measurements are essential for modeling landscape evolution and for discerning how sediment loading affects stream ecosystems. Cosmogenic nuclides such as 10Be in stream sediments can be used to measure whole-catchment erosion rates averaged over thousands of years, a timescale that is unobservable by other methods. Comparing long-term erosion rates from cosmogenic nuclides with short-term sediment yields can shed light on erosional processes and on the effects of land use on sediment delivery to streams. Using cosmogenic 10Be, we measured erosion rates averaged over the past several thousand years at Caspar Creek and Redwood Creek in Northern California. Sediment yields have also been measured at Caspar Creek since 1963 using sediment trapping and gauging methods, and sediment yield data have been collected at Redwood Creek since 1974. The cosmogenic 10Be signature of Caspar Creek sediments indicates an average erosion rate of 0.13 mm/yr, which agrees with the short-term sediment yield data within error. The cosmogenic 10Be signature of Redwood Creek sediments implies an average long-term erosion rate of 0.3 mm/yr, which is in rough agreement with traditional measurements of stream sediment flux. These results imply that the rate of sediment delivery to Caspar Creek and Redwood Creek over the past few decades is broadly consistent with the long-term average rate of sediment production in these watersheds.

  17. Effects of timber harvesting on the lag time of Caspar Creek watershed

    Science.gov (United States)

    Karen Hardison Sendek

    1985-01-01

    Abstract - Hydrograph lag time was analyzed to determine changes after road construction and after selective, tractor-yarded logging in a Caspar Creek watershed, Mendocino County, California. The paired watershed technique was used. Hydrograph lag time for each storm was the time separation between the midpoint of precipitation and the time coordinate of the runoff...

  18. Physical attributes and chemical composition of organic strawberry fruit (Fragaria x ananassa Duch, Cv. Albion) at six stages of ripening.

    Science.gov (United States)

    Ornelas-Paz, José de Jesús; Yahia, Elhadi M; Ramírez-Bustamante, Nidia; Pérez-Martínez, Jaime David; Escalante-Minakata, María del Pilar; Ibarra-Junquera, Vrani; Acosta-Muñiz, Carlos; Guerrero-Prieto, Víctor; Ochoa-Reyes, Emilio

    2013-05-01

    Organic strawberry fruits (Cv. 'Albion') were harvested at six different ripening stages and evaluated for physical and chemical parameters. Biometrical characteristics and moisture content did not change significantly during ripening. Total soluble solids, pH and colour development increased while titratable acidity and fruit firmness decreased 14.7% and 91%, respectively. Fructose, glucose, and sucrose followed similar tendencies. Final contents of these sugars were 2323.4, 1988.5, and 1578.4 mg/100 g. Citric, malic, and ascorbic acids followed a descending, irregular, and increasing tendency during ripening, respectively. Final contents of these acids were 822.8, 245.8, and 78.1 mg/100 g. Total anthocyanins content (TAC) increased during ripening, while the opposite was observed for total phenolic content (TPC). TAC and TPC in ripe fruit were 56.4 mg/100g and 196 mg gallic acid equivalents (GAE)/100 g. Twenty eight phenolic compounds, mainly glycosides, were identified and quantified by HPLC-DAD-MS analysis. The concentration of these compounds was ripening dependent.

  19. Endotracheal tube cuff pressure increases significantly during anterior cervical fusion with the Caspar instrumentation system.

    Science.gov (United States)

    Sperry, R J; Johnson, J O; Apfelbaum, R I

    1993-06-01

    To determine whether endotracheal tube cuff pressure increases significantly with surgical retraction and cervical spine distraction during anterior cervical spine surgery with Caspar instrumentation, we prospectively studied 10 patients undergoing this procedure. The tracheas of all patients were intubated with a Mallinckrodt Hi-Lo endotracheal tube. Tracheal tube cuff pressures measured with a transducer system were 42.4 mm Hg +/- 7.0 mm Hg (SEM) after intubation and cuff inflation. Air was removed from the endotracheal tube cuff until the trachea was just barely sealed at a cuff pressure of 15.2 mm Hg +/- 1.6 mm Hg. The endotracheal tube cuff pressure was readjusted to "just-seal" pressure before the surgeons introduced the Caspar instrumentation. The cuff pressure with traction and distraction was 43.2 mm Hg +/- 5.0 mm Hg. This pressure was significantly increased from the "just-seal" pressure, and from the cuff pressure after instrumentation was discontinued (9.8 mm Hg +/- 2.3 mm Hg). We conclude that anterior cervical spine surgery with Caspar instrumentation is associated with a significant increase in endotracheal tube cuff pressure.

  20. Barriers to Implementing Individualized Substance Abuse Treatment: Qualitative Findings from the CASPAR Replication Studies.

    Science.gov (United States)

    Mericle, Amy A; Casaletto, Kathryn; Knoblach, Dan; Brooks, Adam C; Carise, Deni

    2010-10-01

    Problem-to-services matching is critical to patient-centered care. Further, the extent to which substance abuse treatment is individualized to meet specific client needs is a key predictor of success and represents "best practice" in substance abuse treatment. The CASPAR Resource Guide, an electronic database of local free and low-cost services, is an evidence-based tool designed to help counselors easily and quickly provide offsite referrals to services not available in most community treatment programs to increase problem-to-service matching. This paper examines system-level barriers to using the CASPAR Resource Guide among 30 counselors and 21 site directors across 16 sites in two different studies. Results from qualitative implementation analyses found that key program components needed to support the implementation of this evidence-based practice (e.g., individualized treatment planning, individual treatment sessions, and individual counselor supervision) were lacking, which jeopardized successful adoption of the CASPAR research interventions and prompted a redesign of the studies in order to enhance each program's ability to support individualized care.

  1. Comparison between Measured and Calculated Sediment Transport Rates in North Fork Caspar Creek, California

    Science.gov (United States)

    Kim, T. W.; Yarnell, S. M.; Yager, E.; Leidman, S. Z.

    2015-12-01

    Caspar Creek is a gravel-bedded stream located in the Jackson Demonstration State Forest in the coast range of California. The Caspar Creek Experimental Watershed has been actively monitored and studied by the Pacific Southwest Research Station and California Department of Forestry and Fire Protection for over five decades. Although total annual sediment yield has been monitored through time, sediment transport during individual storm events is less certain. At a study site on North Fork Caspar Creek, cross-section averaged sediment flux was collected throughout two storm events in December 2014 and February 2015 to determine if two commonly used sediment transport equations—Meyer-Peter-Müller and Wilcock—approximated observed bedload transport. Cross-section averaged bedload samples were collected approximately every hour during each storm event using a Helley-Smith bedload sampler. Five-minute composite samples were collected at five equally spaced locations along a cross-section and then sieved to half-phi sizes to determine the grain size distribution. The measured sediment flux values varied widely throughout the storm hydrographs and were consistently less than two orders of magnitude in value in comparison to the calculated values. Armored bed conditions, changing hydraulic conditions during each storm and variable sediment supply may have contributed to the observed differences.

  2. Erosion Rates Over 40-Year and 5,000-Year Timescales at Caspar Creek, Northern California

    Science.gov (United States)

    Ferrier, K. L.; Kirchner, J. W.; Finkel, R. C.

    2002-12-01

    Erosion rate measurements are essential for modeling landscape evolution and for discerning how sediment loading affects stream ecosystems. Cosmogenic nuclides such as 10Be in stream sediments can be used to measure whole-catchment erosion rates averaged over thousands of years, a timescale that is unobservable by other methods. Comparing long-term erosion rates from cosmogenic nuclides with short-term sediment yields can shed light on erosional processes and on the effects of land use on sediment delivery to streams. Using cosmogenic 10Be, we measured erosion rates averaged over the past 5,000 years at Caspar Creek, a small (9 km2) watershed in Mendocino County, California. Sediment yields have also been measured at Caspar Creek since 1963 using sediment trapping and gauging methods. The cosmogenic 10Be signature of Caspar Creek sediments yields an average long-term erosion rate of 0.2 mm/yr. This is 2-3 times faster than erosion rates calculated from traditional stream sediment fluxes averaged over the past 40 years. The long-term rates are comparable to the uplift rate of 0.3 mm/yr inferred from marine terrace ages (Merritts and Bull 1989). These results imply that sediment delivery to streams is episodic, and that conventional sediment yields may underestimate long-term average erosion rates.

  3. A simplified technique for anterior cervical discectomy and fusion using a screw-plate implanted over the Caspar distractor pins.

    Science.gov (United States)

    Fransen, Patrick

    2010-08-01

    The author presents a simplified technique for midline screw-plate fixation in fusion procedures after anterior cervical discectomy, in which the plate is introduced over the Caspar distractor pins. The Uniplate system used, with a single screw in each vertebral body, minimizes bone damage to the vertebral body as the screws can be fixed in the holes previously used for the Caspar distractor pins. This simplified version of the classical anterior cervical fusion technique saves surgical time, facilitates screw insertion, and obviates the need for manipulations to stabilize the plate before the screws are inserted. It provides immediate stability comparable to other plate systems. To the author's knowledge, this is the first report on cervical fusion with the Uniplate system with the plate being introduced over the Caspar distractor pins.

  4. Anterior decompression, structural bone grafting, and Caspar plate stabilization for unstable cervical spine fractures and/or dislocations.

    Science.gov (United States)

    Garvey, T A; Eismont, F J; Roberti, L J

    1992-10-01

    Fourteen patients who sustained acute cervical spine fractures and/or dislocations with associated posterior ligamentous disruption had anterior decompressions, structural bone grafting, and anterior Caspar plate stabilization. With an average 30-month follow-up, no patient has had loss of fixation. Despite criticism raised from biomechanical testing, the Caspar anterior plate system (Aesculape, Tuttlingen, Germany) may be added to structural bone grafting of unstable cervical fractures and/or dislocations, yielding an in vivo solid construct, which obviates the need for simultaneous posterior stabilization.

  5. Modifications to the transverse Caspar cervical retractor blades optimized for a single-level anterior cervical discectomy.

    Science.gov (United States)

    Geisler, F H; Tamargo, R J; Weingart, J D

    1993-02-01

    A modification of the transverse Caspar cervical soft-tissue retractor blades for their use in a single-level anterior cervical discectomy is presented. These modified retractor blades are similarly inserted into the elevated anterior mesial portion of the longus colli muscles. However, they allow a smaller skin incision, less soft-tissue dissection, and do not require use of the superior and inferior smooth retractor blades, while providing the same surgical vision and operative ability in the disc space as does the four-bladed Caspar retractor system.

  6. Radiographic and clinical follow-up review of Caspar plates in 49 patients.

    Science.gov (United States)

    Paramore, C G; Dickman, C A; Sonntag, V K

    1996-06-01

    Although they are excellent clinical tools, Caspar anterior cervical plates have not been studied closely with regard to their mechanisms of failure. As more extensive operations are contemplated on older, sicker patients, it is imperative to know when a plating system might be prone to failure and what the mechanism of that failure might be. Therefore, the authors reviewed 49 patients undergoing Caspar plate placement in whom sufficient radiographs were obtained to determine if the fate of the hardware was related to the patient's age, type of operation, and the length of construct. Eleven of 49 patients suffered hardware failure, defined as any amount of screw backout or breakage, plate pullout, or pseudarthrosis. Four patients underwent hardware removal; one underwent posterior fusion for pseudarthrosis. Only two required treatment in a halo brace. There was an eventual fusion rate of 100%, including one fibrous union, and one of the patients who underwent repeat surgery was lost to follow-up review. No graft extrusions or new neurological deficits were incurred as a result of hardware failure. Plate length predicted plate failure in a statistically significant manner. Increasing age and reoperation correlated with plate failure but were not statistically significant in this small number of patients. Telescoping of the bone graft and vertebral bodies, with concomitant migration of the plate and slippage of the screws, was common. However, telescoping was more profound in the group in which the plates failed. The authors conclude that Caspar plate failures are more likely to occur in the elderly and in patients who need longer constructs. Bone fusion can be expected even when the hardware loosens.

  7. Long-term Preservation of Earth Observation Data and Knowledge in ESA through CASPAR

    Directory of Open Access Journals (Sweden)

    Sergio Albani

    2009-12-01

    Full Text Available ESA-ESRIN, the European Space Agency Centre for Earth Observation (EO, is the largest European EO data provider and operates as the reference European centre for EO payload data exploitation. EO Space Missions provide global coverage of the Earth across both space and time generating on a routine continuous basis huge amounts of data (from a variety of sensors that need to be acquired, processed, elaborated, appraised and archived by dedicated systems. Long-term Preservation of these data and of the ability to discover, access and process them is a fundamental issue and a major challenge at programmatic, technological and operational levels.Moreover these data are essential for scientists needing broad series of data covering long time periods and from many sources. They are used for many types of investigations including ones of international importance such as the study of the Global Change and the Global Monitoring for Environment and Security (GMES Program. Therefore it is of primary importance not only to guarantee easy accessibility of historical data but also to ensure users are able to understand and use them; in fact data interpretation can be even more complicated given the fact that scientists may not have (or may not have access to the right knowledge to interpret these data correctly.To satisfy these requirements, the European Space Agency (ESA, in addition to other internal initiatives, is participating in several EU-funded projects such as CASPAR (Cultural, Artistic, and Scientific knowledge for Preservation, Access and Retrieval, which is building a framework to support the end-to-end preservation lifecycle for digital information, based on the OAIS reference model, with a strong focus on the preservation of the knowledge associated with data.In the CASPAR Project ESA plays the role of both user and infrastructure provider for one of the scientific testbeds, putting into effect dedicated scenarios with the aim of validating the

  8. Syn-extensional plutonism and peak metamorphism in the albion-raft river-grouse creek metamorphic core complex

    Science.gov (United States)

    Strickland, A.; Miller, E.L.; Wooden, J.L.; Kozdon, R.; Valley, J.W.

    2011-01-01

    The Cassia plutonic complex (CPC) is a group of variably deformed, Oligocene granitic plutons exposed in the lower plate of the Albion-Raft River- Grouse Creek (ARG) metamorphic core complex of Idaho and Utah. The plutons range from granodiorite to garnet-bearing, leucogranite, and during intrusion, sillimanite- grade peak metamorphism and ductile attenuation occurred in the country rocks and normal-sense, amphibolite-grade deformation took place along the Middle Mountain shear zone. U-Pb zircon geochronology from three variably deformed plutons exposed in the lower plate of the ARG metamorphic core complex revealed that each zircon is comprised of inherited cores (dominantly late Archean) and Oligocene igneous overgrowths. Within each pluton, a spread of concordant ages from the Oligocene zircon overgrowths is interpreted as zircon recycling within a long-lived magmatic system. The plutons of the CPC have very low negative whole rock ??Nd values of -26 to -35, and initial Sr values of 0.714 to 0.718, consistent with an ancient, crustal source. Oxygen isotope ratios of the Oligocene zircon overgrowths from the CPC have an average ??18O value of 5.40 ?? 0.63 permil (2SD, n = 65) with a slight trend towards higher ??18O values through time. The ??18O values of the inherited cores of the zircons are more variable at 5.93 ?? 1.51 permil (2SD, n = 29). Therefore, we interpret the plutons of the CPC as derived, at least in part, from melting Archean crust based on the isotope geochemistry. In situ partial melting of the exposed Archean basement that was intruded by the Oligocene plutons of the CPC is excluded as the source for the CPC based on field relationships, age and geochemistry. Correlations between Ti and Hf concentrations in zircons from the CPC suggest that the magmatic system may have become hotter (higher Ti concentration in zircon) and less evolved (lower Hf in zircon concentration) through time. Therefore, the CPC represents prolonged or episodic magmatism

  9. The role of Caspar Bartholin the Elder in the evolution of the terminology of the cranial nerves.

    Science.gov (United States)

    Porzionato, Andrea; Macchi, Veronica; De Caro, Raffaele

    2013-01-01

    In the 17th century, the Bartholin family contributed greatly to the advancement of anatomical and medical science. Caspar Bartholin the Elder (1585-1629) introduced the terms nervus olfactorius and nervus vagus in 1611 in the Institutiones Anatomicae. Thomas Bartholin (1616-1680) extended their use to figures added to later revised editions of Institutiones Anatomicae.

  10. Hybrid ambitions : science, governance, and empire in the career of Caspar G.C. Reinwardt (1773-1854)

    NARCIS (Netherlands)

    Weber, Andreas

    2012-01-01

    The German chemist-apothecary Caspar Georg Carl Reinwardt (1773-1854) offers a fascinating window on Dutch culture and society in the late eighteenth and early nineteenth centuries. By providing an in-depth analysis of his multi-faceted career in the Netherlands and the Malay Archipelago, this study

  11. Hybrid Ambitions: Science, Governance, and Empire in the Career of Caspar C.G. Reinwardt (1773-1854)

    NARCIS (Netherlands)

    Weber, A.

    2012-01-01

    The German chemist-apothecary Caspar Georg Carl Reinwardt (1773-1854) offers a fascinating window on Dutch culture and society in the late eighteenth and early nineteenth centuries. By providing an in-depth analysis of his multi-faceted career in the Netherlands and the Malay Archipelago, this study

  12. Caspar Paludan-Müller - Zur frühen Ranke-Rezeption in Dänemark

    DEFF Research Database (Denmark)

    Møller, Jes Fabricius

    2007-01-01

    Den danske reception af Leopold von Rankes værker og historismen skete i overvejende grad gennem Caspar Paludan-Müller, der også anvendte de kildekritiske principper, der hørte til Rankes og Niebuhrs historisme. Historismen og dermed også Paludan-Müllers verdensbillede blev udsat for et stadig st...

  13. Hybrid ambitions : science, governance, and empire in the career of Caspar G.C. Reinwardt (1773-1854)

    NARCIS (Netherlands)

    Weber, Andreas

    2012-01-01

    The German chemist-apothecary Caspar Georg Carl Reinwardt (1773-1854) offers a fascinating window on Dutch culture and society in the late eighteenth and early nineteenth centuries. By providing an in-depth analysis of his multi-faceted career in the Netherlands and the Malay Archipelago, this study

  14. Biomechanical evaluation of Caspar and Cervical Spine Locking Plate systems in a cadaveric model.

    Science.gov (United States)

    Clausen, J D; Ryken, T C; Traynelis, V C; Sawin, P D; Dexter, F; Goel, V K

    1996-06-01

    There exist two markedly different instrumentation systems for the anterior cervical spine: the Cervical Spine Locking Plate (CSLP) system, which uses unicortical screws with a locking hub mechanism for attachment, and the Caspar Trapezial Plate System, which is secured with unlocked bicortical screws. The biomechanical stability of these two systems was evaluated in a cadaveric model of complete C5-6 instability. The immediate stability was determined in six loading modalities: flexion, extension, right and left lateral bending, and right and left axial rotation. Biomechanical stability was reassessed following fatigue with 5000 cycles of flexion-extension, and finally, the spines were loaded in flexion until the instrumentation failed. The Caspar system stabilized significantly in flexion before (p < 0.05) but not after fatigue, and it stabilized significantly in extension before (p < 0.01) and after fatigue (p < 0.01). The CSLP system stabilized significantly in flexion before (p < 0.01) but not after fatigue, and it did not stabilize in extension before or after fatigue. The moment needed to produce failure in flexion did not differ substantially between the two plating systems. The discrepancy in the biomechanical stability of these two systems may be due to differences in bone screw fixation.

  15. Caspar Jørgensen & Morten Pedersen (eds., Industrial Heritage in Denmark: Landscapes, Environments and Historical Archaeology (Aarhus: Kultur Styrelsen & Aarhus University Press, 2015

    Directory of Open Access Journals (Sweden)

    Þóra Pétursdóttir

    2016-03-01

    Full Text Available Book review of: Caspar Jørgensen and Morten Pedersen (eds., Industrial Heritage in Denmark: Landscapes, Environments and Historical Archaeology (Aarhus: Kultur Styrelsen and Aarhus University Press, 2015, 285 pp. ISBN 978 87 7124 108 2

  16. [Recurrent depressive disorder in Caspar David Friedrich. A pathographical approach with operationalized diagnosis].

    Science.gov (United States)

    Spitzer, C; Dahlenburg, B; Freyberger, H J

    2006-07-01

    Caspar David Friedrich (1774 - 1840) is one of the most important German Romantic painters. In his paintings, he prototypically represents the melancholy, which has been mentioned by his contemporaries and later biographers. Art scientists have also referred to his melancholy for the interpretation of his work. From a medical point of view, there are only two pathographies which remain inconclusive. Having applied diagnostic criteria for psychiatric disorders to his letters and publications, to statements of his contemporaries and to his art, we propose that he had suffered from a recurrent major depression which occurred in 1799 for the first time. At least three depressive episodes followed before he was struck by a stroke in 1835. There are epidemiological, psychodynamic and personality-typological reasons supporting our diagnostic assumption. The course of his depression corresponds to phases of reduced creativity, to the chosen techniques and motives. Finally we discuss the implications of our approach for the pathographical method in general.

  17. The CASPAR underground accelerator facility for the study of low energy nuclear astrophysics

    Science.gov (United States)

    Robertson, Daniel; Couder, Manoel; Greife, Uwe; Strieder, Frank; Wiescher, Michael

    2016-09-01

    The drive of nuclear astrophysics is to push the limits of reaction measurements into the burning regime of astrophysical interest. As current laboratory experiments approach the stellar burning window, the rapid drop off of cross-sections is a significant barrier and drives the need for higher intensity accelerators, more robust and isotopically enriched target material and lower background interference. The natural background suppression of underground accelerator facilities enables the extension of current experimental data to the lower energies needed. The CASPAR facility is the first and only underground accelerator facility in the US, focused on the study of low energy reactions of nuclear astrophysical interest. Support provided by NSF Grant No. PHY 1419765, JINA-CEE Grant No. PHY 1430152 and the South Dakota Science and Technology Authority.

  18. Channel Incision and Suspended Sediment Delivery at Caspar Creek, Mendocino County, California.

    Science.gov (United States)

    Dewey, N. J.; Lisle, T. E.; Reid, L. M.

    2003-12-01

    Tributary and headwater valleys in the Caspar Creek watershed, in coastal Mendocino County, California, show signs of incision along much of their lengths. An episode of incision followed initial-entry logging which took place between 1860 and 1906. Another episode of incision cut into skid-trails created for second-entry logging in the 1970's. Gullies resulting from both of these episodes of incision are sensitive to hydrologic fluctuations and feature active headcuts, deepening plungepools, and unstable banks, which continue to contribute sediment to the Caspar Creek channel network. Headcuts are numerous in each channel. In some cases headcuts define the upstream extent of an incised reach; in many cases headcuts migrate up previously incised reaches, increasing the depth of incision. Surveys indicate that bank retreat, plunge pool deepening, and headcut retreat all contributed sediment to the channels between 2000 and 2003. Since bank walls have considerably more surface area than headwalls per given length of channel, and headcuts have largely migrated into positions temporarily constrained by resistant lips, bankwall retreat appears to be a more significant chronic source of sediment than headwall retreat. Stream gage records show that some channels consistently deliver higher levels of suspended sediment than others. In comparing channels, ongoing levels of suspended sediment delivery correlate well with total amount of exposed channel bank (depth of incision integrated over length of channel) in the reaches upstream of stream gages. On an annual to decadal time-scale, rates of suspended sediment delivery per unit area of catchment correlate better with the amount of exposed bank area in reaches upstream of stream gages, than with the volume of sediment delivered by landslide events, with total catchment area, or with peak storm flow per unit area. The correlation between amount of exposed bank area and ongoing levels of suspended sediment delivery is

  19. [The unfolding of the blood circulation doctrine: the correspondence between William Harvey and Caspar Hofmann in May 1636].

    Science.gov (United States)

    Rebollo, Regina André

    2002-01-01

    The present article analyzes the letters exchanged by Caspar Hofmann and William Harvey in 1636 and the delineation of the main questions and answers on the blood circulation theory. The first part of the article presents concepts about blood circulation according to the time's physiology; the second part presents the changes introduced by Harvey; the third and last part presents the debate between Hofmann and Harvey.

  20. Forest Management Effects on Channel Wood and Wood-Channel Interactions in Caspar Creek, California

    Science.gov (United States)

    Hilton, S.

    2006-12-01

    First-cycle logging in much of California's redwood region converted streams with some of the highest known wood volumes and piece sizes to efficient log transport channels. A century later, second-growth trees are still much smaller than old growth, and later logging and stream cleaning have further affected potential wood inputs and large woody debris (LWD) volumes in channels. At Caspar Creek, a 50-year paired watershed study creates an opportunity to compare the effects of two second-growth forest management strategies on wood dynamics in these channels, and to examine how the resulting differences in LWD affect channel form and process. Both the North and South Forks of Caspar Creek started the 20th century with almost no in-channel wood and little potential LWD as a result of clearcut logging, burning, and channel clearing. Stands had partially regrown by 1968, when near-channel roadbuilding and selective logging in the 424-ha South Fork watershed again reduced potential channel LWD. Trees that fell into the channel during logging were removed, along with some instream wood. Logging began in the 384-ha North Fork in 1989 using ridgetop roads; buffer strips were left between the mainstem channel and upslope clearcuts. Potential LWD in the buffer strips was reduced by selective cutting, but channel LWD was not immediately affected. LWD mapping, inventories, and tagging, channel cross-sections and photos, and pool mapping and volume measurements show differences in channel wood and LWD-channel interactions between the two watersheds. Windthrow from buffer strips increased the total channel LWD volume in the North Fork in the mid 1990's while reducing potential future LWD. These higher LWD loads increased pool volumes and enabled increased sediment storage, particularly upstream of logjams. In the South Fork, total LWD volumes are lower and a higher proportion of the wood is residual old growth pieces, some of which entered the channel during the 1970's logging

  1. [Health pedagogy instead of consolation. Theological adjustment to illness by Philipp Melanchthon and Caspar Peucer].

    Science.gov (United States)

    Bröer, R; Hofheinz, R

    2001-01-01

    Subject of this paper is the interpretation of disease as physical evil (malum physicum) by the university professors Philipp Melanchthon (1497-1560) and Caspar Peucer (1525-1602) at Protestant Wittenberg. Melanchthon and Peucer settled the problem of theodicy principally by theological strategies of moralization and compensation. In most cases, therefore, disease resulted from inadequate health behavior, especially drunkenness, furthermore from disdain for medicine and obstruction of divine healing. As a rule, natural factors (e.g. celestial bodies or human affections) only contributed to disease. In general it was caused by free will. In consequence the strategies of depotentiation and functionalization of disease became insignificant resulting in the accentuation of its evil nature. By way of compensation Melanchthon and Peucer stressed the Divine healing of disease. God created the natural remedies and later He created the medical arts by granting heroic virtue to the greatest doctors (Hippocrates, Galen, Avicenna). Moreover the divine Trinity could directly harmonize affections. Thus, God incited a psychosomatical healing within the human organism. As far as physical evil is concerned Lutheran pathology substituted medieval pessimism for therapeutical optimism. Melanchthon and Peucer strived to discipline the patients' behavior and to legitimate the medical arts by God. In this sense their pathology formed part of a program of social and religious stabilization. The academic medicine profited greatly from that program in later years.

  2. Simulation of Partially Saturated - Saturated Flow in the Caspar Creek E-Road Groundwater System

    Science.gov (United States)

    Fisher, J.; Fisher, J.

    2001-12-01

    Over the past decade, the U.S. Forest Service has monitored the subsurface hillslope flow of the E-Road swale. The swale is located in the Caspar Creek watershed near Fort Bragg, California. In hydrologic year 1990 a logging road was built across the middle section of the hillslope followed by a total clearcut of the area during the following year. Development of the logging road has resulted in a large build up of subsurface waters upslope of the road. The increase in pore pressures behind the road is of major concern for slope stability and road failure. A conceptual model is developed to describe the movement of water within the E-Road groundwater system. The two-dimensional SUTRA model is used to describe both saturated and partially saturated flow within the system. SUTRA utilizes a finite element and integrated finite difference method to approximate the governing equation for flow. The model appears to reproduce the uniquely different frequency responses within the E-Road groundwater system. A comparison of simulated and historical piezometric responses demonstrates the model's inability to reproduce historical drainage rates. The low rates of simulated drainage are attributed to the absence of pipeflow within the model. Finally, road consolidation is associated with increased water pressures beneath the road bed.

  3. Caspar Paludan-Müller - Zur frühen Ranke-Rezeption in Dänemark

    OpenAIRE

    Møller, Jes Fabricius

    2007-01-01

    Den danske reception af Leopold von Rankes værker og historismen skete i overvejende grad gennem Caspar Paludan-Müller, der også anvendte de kildekritiske principper, der hørte til Rankes og Niebuhrs historisme. Historismen og dermed også Paludan-Müllers verdensbillede blev udsat for et stadig større pres i løbet af det 19. århundrede. og især Kristian Erslevs kritik af Paludan-Müller skal ses som et udtryk for modernismens og positivismens fremkomst. Erslevs kritik af Paludan-Müller var Ersl...

  4. Voice of Young People in Care: "Don't Be so Formal, I'm Normal" Caspar Conference, Belfast, Northern Ireland, January 25, 2007

    Science.gov (United States)

    McGinnity, Aine

    2007-01-01

    In this article, the author gives a summary of a conference, organized by Voice of Young People in Care (VOYPIC). The event celebrated the publication of the Caspar Research Report--a report on the mental health of looked-after children and care leavers in Northern Ireland. The event was opened by Vivian McConvey, Director of VOYPIC, who gave some…

  5. Selected Findings on the Impact of the CASPAR Alcohol Education Program on Teacher Training and Curriculum Implementation. Evaluation Report No. 8.

    Science.gov (United States)

    Carifio, James; And Others

    The Cambridge and Somerville (Massachusetts) Program for Alcoholism Rehabilitation (CASPAR) was instituted to train teachers and social service workers in implementing alcohol education programs; to train selected high school students as peer leaders; and to promote community awareness of alcohol-related problems. A sequential cycle evaluation…

  6. Development of a Remodeled Caspar Retractor and Its Application in the Measurement of Distractive Resistance in an In Vitro Anterior Cervical Distraction Model.

    Science.gov (United States)

    Wen, Junxiang; Xu, Jianwei; Li, Lijun; Yang, Mingjie; Pan, Jie; Chen, Deyu; Jia, Lianshun; Tan, Jun

    2017-06-01

    In vitro biomechanical study of the cervical intervertebral distraction using a remodeled Caspar retractor. To investigate the torques required for distraction to different heights in an in vitro C3-C4 anterior cervical distraction model using a remodeled Caspar retractor, focusing on the influence of the intervertebral disk, posterior longitudinal ligament (PLL), and ligamentum flavum (LF). No previous studies have reported on the torques required for distraction to various heights or the factors resisting distraction in anterior cervical discectomy and fusion. Anterior cervical distractions at C3-C4 was performed in 6 cadaveric specimens using a remodeled Caspar retractor, under 4 conditions: A, before disk removal; B, after disk removal; C, after disk and PLL removal; and D, after disk and PLL removal and cutting of the LF. Distraction was performed for 5 teeth, and distractive torque of each tooth was recorded. The torque increased with distraction height under all conditions. There was a sudden increase in torque at the fourth tooth under conditions B and C, but not D. Under condition A, distraction to the third tooth required 84.8±13.3 cN m. Under conditions B and C, distraction to the third tooth required resistance may help to determine the optimal distraction height to avoid excessive stress to the endplate spacer. The remodeled Caspar retractor in the present study may provide a feasible and convenient method for intraoperative measurement of distractive resistance.

  7. The timing of tertiary metamorphism and deformation in the Albion-Raft River-Grouse Creek metamorphic core complex, Utah and Idaho

    Science.gov (United States)

    Strickland, A.; Miller, E.L.; Wooden, J.L.

    2011-01-01

    The Albion-Raft River-Grouse Creek metamorphic core complex of southern Idaho and northern Utah exposes 2.56-Ga orthogneisses and Neoproterozoic metasedimentary rocks that were intruded by 32-25-Ma granitic plutons. Pluton emplacement was contemporaneous with peak metamorphism, ductile thinning of the country rocks, and top-to-thewest, normal-sense shear along the Middle Mountain shear zone. Monazite and zircon from an attenuated stratigraphic section in the Middle Mountain were dated with U-Pb, using a SHRIMP-RG (reverse geometry) ion microprobe. Zircons from the deformed Archean gneiss preserve a crystallization age of 2532 ?? 33 Ma, while monazites range from 32.6 ?? 0.6 to 27.1 ?? 0.6 Ma. In the schist of the Upper Narrows, detrital zircons lack metamorphic overgrowths, and monazites produced discordant U-Pb ages that range from 52.8 ?? 0.6 to 37.5 ?? 0.3 Ma. From the structurally and stratigraphically highest unit sampled, the schist of Stevens Spring, narrow metamorphic rims on detrital zircons yield ages from 140-110 Ma, and monazite grains contained cores that yield an age of 141 ??2 Ma, whereas rims and some whole grains ranged from 35.5 ?? 0.5 to 30.0 ?? 0.4 Ma. A boudinaged pegmatite exposed in Basin Creek is deformed by the Middle Mountains shear zone and yields a monazite age of 27.6 ?? 0.2 Ma. We interpret these data to indicate two periods of monazite and metamorphic zircon growth: a poorly preserved Early Cretaceous period (???140 Ma) that is strongly overprinted by Oligocene metamorphism (???32-27 Ma) related to regional plutonism and extension. ?? 2011 by The University of Chicago.

  8. Linkage analyses in type I diabetes mellitus using CASPAR, a software and statistical program for conditional analysis of polygenic diseases.

    Science.gov (United States)

    Buhler, J; Owerbach, D; Schäffer, A A; Kimmel, M; Gabbay, K H

    1997-01-01

    We have developed software and statistical tools for linkage analysis of polygenic diseases. We use type I diabetes mellitus (insulin-dependent diabetes mellitus, IDDM) as our model system. Two susceptibility loci (IDDM1 on 6p21 and IDDM2 on 11p15) are well established, and recent genome searches suggest the existence of other susceptibility loci. We have implemented CASPAR, a software tool that makes it possible to test for linkage quickly and efficiently using multiple polymorphic DNA markers simultaneously in nuclear families consisting of two unaffected parents and a pair of affected siblings (ASP). We use a simulation-based method to determine whether lod scores from a collection of ASP tests are significant. We test our new software and statistical tools to assess linkage of IDDM5 and IDDM7 conditioned on analyses with 1 or 2 other unlinked type I diabetes susceptibility loci. The results from the CASPAR analysis suggest that conditioning of IDDM5 on IDDM1 and IDDM4, and of IDDM7 on IDDM1 and IDDM2 provides significant benefits for the genetic analysis of polygenic loci.

  9. Gully Development in Tributaries to Caspar Creek, Northern California Coast Range

    Science.gov (United States)

    Dewey, N. J.; Lisle, T. E.; Reid, L. M.

    2002-12-01

    Incision of tributaries to Caspar Creek, a gaged Coast Range watershed in Northern California, appears to be an ongoing process that may account for a significant sediment output. Gullied reaches with fresh headcuts and steep banks, indicative of incision, are documented in environments ranging from zero-order swales through third-order channels draining over 50 hectares. Gully size ranges from 0.25 to 25 m2 in cross-sectional area. Gully volume per watershed ranges from 10 to 60 m3 per hectare. Multiple gully headcuts migrate up each channel; typically there are 2 to 5 headcuts taller than 0.8 meters and 3 to 10 smaller headcuts present per 100 m of gullied channel. A variety of processes appear to be responsible for the initiation and propagation of gullies. In the higher reaches of each tributary, gullies are closely associated with pipe-collapse and landslide features. Typically these high slope gullies are separated by unchanneled reaches. Once discontinuous gullies are established at these sites, headcut migration allows them to expand upslope. Lower in the system, plunge pool erosion appears to play a larger role and gullies are part of a continuous channel. A transition from discontinuous gullies to a continuous channel typically occurs at a drainage area of 3 to 10 hectares. Recent disturbance and road runoff allow formation of continuous channels at lower drainage areas. At least two episodes of post-logging gully development occurred. The largest gullies undercut old-growth stumps and old roots in areas which were not subsequently disturbed. These gullies appear to have been activated after an initial logging entry in the late 1800's and early 1900's; some of these older gullies appear to be partially stabilizing. Other gullies clearly postdate logging and skid-trail building in the early 1970's. Incised channels were filled during 1970's logging in the South Fork, and are now being reincised. The most active gullies occur in the locations logged in the

  10. Causal pathways for asthma (CASPAR – MoBa “a happy hunting ground”

    Directory of Open Access Journals (Sweden)

    Wenche Nystad

    2014-12-01

    Full Text Available Large population-based research cohorts, together with national health registries and biobanks are core components in a modern infrastructure for knowledge. Along with the other Nordic countries, Norway has unique opportunities for high quality research based on cohorts, biobanks and registries. Cohorts, biobanks and registries provide a basis for discovering causes and mechanisms of disease as well as for following the development of disease, effects of treatment and consequences of disease. The purpose of this manuscript is to give a brief outline of a project that makes use of these unique opportunities by using data from The Norwegian Mother and Child cohort study (MoBa to address research questions of common interest, and thus encourage other research groups to use this “happy hunting ground”.The present study, Causal Pathways for Asthma (CASPAR funded by the Research Council of Norway, is a subproject of MoBa. The project is designed to take advantage of the potential for research on human biological material in biobanks, by coupling analysis results with data from health surveys, health registries and the health services. The present study is based on an ongoing collaboration between the Norwegian Institute of Public Health (NIPH, the National Institute of Environmental Health Sciences (NIEHS in the US and several other national and international collaborators within The MoBa Asthma Group. The main aim of the study is to examine a number of hypothesis regarding in utero and early life exposures in relation to the development of different phenotypes of asthma and allergies in childhood.For the majority of children who become asthmatic and allergic, the differentiation of their immune system into an atopic phenotype probably begins before birth and is established within the first six years of life. This study will advance knowledge of the mechanisms whereby diet and environmental exposures influences gene expression to alter risk of

  11. Caspar Luyken’s illustrated bible among the Serbs and Bulgarians in the eighteenth and nineteenth centuries

    Directory of Open Access Journals (Sweden)

    Stošić Ljiljana

    2011-01-01

    Full Text Available The engraving of the Finding of Moses from Caspar Luyken’s Amsterdam (1694 and Nuremberg (1708 bibles served as a model for Teodor Kračun’s painting for the small iconostasis of the Orthodox cathedral in Sremski Karlovci (1780, for the Viennese printer J. G. Mansfeld’s frontispiece of Dositej Obradović’s Poem of the Deliverance of Serbia (1789 and for Dimitar Zograf ’s fresco in the vault of the exonarthex of the Rila Monastery (1843. Three different versions of the original copper engraving reveal how Luyken’s Bible was used in support of the cause of religious revival and national liberation of the Serbs and Bulgarians in the Habsburg and Ottoman empires respectively in the late eighteen century and the first half of the nineteenth.

  12. Low accuracy of stem implantation in THR using the CASPAR-system: anteversion measurements in 10 hips.

    Science.gov (United States)

    Mazoochian, Farhad; Pellengahr, Christoph; Huber, Armin; Kircher, Jörn; Refior, Hans Jürgen; Jansson, Volkmar

    2004-06-01

    We studied 10 patients by means of pre- and postoperative CT who underwent computer-assisted total hip replacement using the CASPAR-system (OrthoMaquet GmbH, Rastatt, Germany). The anteversion angles of the stem and translational deviations measured after surgery were compared to the preoperatively planned ones as a quality control. We found an average difference of 7.8 degrees (SD 6.3 degrees; 95% CI 3.3 degrees-12.3 degrees) in the angles and an average difference of 1.8 (SD 1.7; 95% CI 0.6-3.0) mm and 1.2 (SD 1.4: 95% CI 0.25-2.2), respectively, in the medial and lateral deviation. In conclusion, we could not confirm the same accuracy of implant position as that claimed by the manufacturer.

  13. Tracking Sediment Movement with Pittag Surveys during Storm Events in the North Fork of Caspar Creek, California

    Science.gov (United States)

    Leidman, S. Z.; Yarnell, S. M.; Yager, E.

    2015-12-01

    Caspar Creek is a gravel-bedded stream near Fort Bragg in Jackson Demonstration State Forest in Northern California's Coast Range. Since 1962, detailed measurements of streamflow, turbidity, and rainfall have been made at a weir just below the study area by the Pacific Southwest Research Station and California Department of Forestry and Fire Protection (CAL FIRE). However, little research has been done to identify how gravel-sized sediment moves through the system during storm flows. The North Fork of Caspar Creek drains a relatively small and steep watershed providing fast residence times that allow direct correlation between rainfall events and movement of the gravel-dominated (<20% sand) bed material. The study reach has an average discharge of 3.8x10-2 m3/s, yet over the past two years has had 4 storm events with flows greater than 1.0 m3/s, a flow that has shown to be a minimum needed for bedload movement. Gravel sized rocks inserted with HDX pit tags were placed throughout the study reach and surveyed after each storm to track their movement through the system. The results show that bed movement responds nonlinearly to increased peak storm discharge with larger storms disproportionately moving sediment further downstream. The movement distances appear independent of local slope, and the distribution of transported sediment sizes does not show significant variance between different storm events. This info will contribute to a better understanding of gravel deposition and bar formation in rainfall-driven watersheds and may help predict sediment fluxes during storm events.

  14. [Caspar Friedrich Wolff (1734-1794). The concept of epigenesis and the problem of spontaneous generation].

    Science.gov (United States)

    Bednarczyk, Andrzej

    2005-01-01

    The link between the notion of epigenesis and that of spontaneous generation does not seem complicated when it is viewed in theoretical terms or when it is approached in a pure model form. However, once any of its particular manifestations in the history of biology is analysed, the interrelationship between the two notions ceases to be unequivocal. One example of that comes with the first fully-fledged concept of epigenesis, based on careful observation of embryonic development, presented by Caspar Friedrich Wolff in the 18th century. The process of development that an act of spontaneous generation has given rise to cannot, of course, be anything else but one of epigenesis. In this sense, epigenesis constitutes a necessary condition for spontaneous generation, but is not a sufficient condition, i.e. not every process of development through epigenesis has at its source an act of spontaneous generation. Evidence that Wolff was inclined towards the concept of spontaneous generation comes from the presence in his works of a notion described by the Latin term ortus (emergence). That notion--together with that of an organic body--is subject to detailed analysis in the current paper. If the process of spontaneous generation is understood as a process of emergence in nature of what is animate and organic, from what is inanimate and non-organic, and as a process in which living beings are not involved, but a living being is its outcome, then the notion of ortus is close in meaning to the notion of spontaneous generation. However, the deistic and theological philosophical foundation of Wolff's concept of epigenesis is in conflict with the notion of spontaneous generation. It seems that Wolff's notion of ortus can be interpreted in two ways. Firstly, it can be interpreted as as result of the theoretical extrapolation in time applied by Wolff to the usual way in which organic bodies emerge (the process is always given rise to by a nonorganic body, supplied by another organic

  15. Problems in Determining the Return of a Watershed to Pretreatment Conditions: Techniques Applied to a Study at Caspar Creek, California

    Science.gov (United States)

    Thomas, Robert B.

    1990-09-01

    Using a previously treated basin as a control in subsequent paired watershed studies requires the control to be stable. Basin stability can be assessed in many ways, some of which are investigated for the South Fork of Caspar Creek in northern California. This basin is recovering from logging and road building in the early 1970s. Three storm-based discharge characteristics (peak discharge, quick flow, and total storm flow), daily flows, and concentration of suspended sediment were studied to see if the South Fork can be used as a control in a second experiment. Mean sediment concentration in three discharge classes and regression parameters for the other data were tested to estimate remaining treatment effects relative to the North Fork. Patterns of change were similar for most data, with rises in response followed by returns toward pretreatment conditions. The storm and sediment data showed few significant differences, but tests on daily flows indicated that differences still exist. The overall evidence suggests that the South Fork has returned to near pretreatment conditions. Better sediment data are needed for studies of the effects of land management.

  16. [The "Tractatus de balneis Germaniae" by Caspar Schober (around 1530). On the status of early balneology in Germany between mineral source analysis and corresponding reports].

    Science.gov (United States)

    Fürbeth, F

    1996-01-01

    Caspar Schober, an Austrian physician of the early 16th century, wrote a treatise concerning the most famous German spas. In this treatise he describes a method to analyse the hot springs in Gastein to know their therapeutic effects. With this description he is one of the first scientific authors in Germany dealing with the modern analysis of hot springs used by the Italian balneologists; in fact he is writing in the same textual paradigm as Menghus Blanchellus in his "Consilium de balneo Villae'. The second part of his treatise about the spas of Baden near Vienna, Markgrafenbad, Wiesbaden, Aachen, Wildbad in the Black Forest, Pfäfers and Baden in Switzerland depends on a hitherto unknown latin redaction of the "Tractatus de balneis naturalibus' of Felix Hemmerli, probably written by the Munich physician Johannes Hartlieb.

  17. Form--a matter of generation: the relation of generation, form, and function in the epigenetic theory of Caspar F. Wolff.

    Science.gov (United States)

    Witt, Elke

    2008-12-01

    The question, how organisms obtain their specific complex and functional forms, was widely discussed during the eighteenth century. The theory of preformation, which was the dominant theory of generation, was challenged by different alternative epigenetic theories. By the end of the century it was the vitalist approach most famously advocated by Johann Friedrich Blumenbach that prevailed. Yet the alternative theory of generation brought forward by Caspar Friedrich Wolff was an important contribution to the treatment of this question. He turned his attention from the properties of matter and the forces acting on it towards the level of the processes of generation in order to explain the constitution of organismic forms. By regarding organic structures and forms to be the result of the lawfulness of ongoing processes, he opened up the possibility of a functional but non-teleological explanation of generation, and thereby provided an important complement to materialist and vitalist approaches.

  18. Anterior cervical fusion and osteosynthetic stabilization according to Caspar: a prospective study of 41 patients with fractures and/or dislocations of the cervical spine.

    Science.gov (United States)

    Goffin, J; Plets, C; Van den Bergh, R

    1989-12-01

    Between June 1984 and April 1988, 41 patients with severe posttraumatic lesions of the cervical spine between the C2-C3 and the C7-T1 level seen consecutively were treated by an anterior cervical fusion and osteosynthetic stabilization according to Caspar. These patients were prospectively studied. Seven patients had a bilateral facet dislocation, 5 a unilateral facet dislocation, 9 an anterior subluxation, 9 an anterior compression fracture, 5 a hangman's fracture, and 6 a hyperextension injury at a lower cervical level. From a neurological point of view, there were 12 patients with an initial complete transverse lesion and 14 with an incomplete transverse lesion, and the remaining 15 patients did not have any deficit initially. Four patients died during the first 3 months after the operation. In 38 patients good anatomical position was obtained, generally by the intraoperative use of the vertebral distractor of Caspar. In all patients excellent immediate postoperative stability of the spine was obtained, although in 2 patients a second operation was necessary a few days after the first one. Postoperatively all patients were "immobilized" by a soft collar for 3 months. Four patients with an initial complete transverse lesion showed some neurological recovery in the postoperative period, and all patients with an incomplete transverse lesion improved. There were no postoperative neurological disturbances in the group of patients who were neurologically normal from the beginning. The mean postoperative hospitalization time was 13.6 days. These results were compared to the results from the literature, concerning other conservative and operative treatments for posttraumatic lesions of the cervical spine.

  19. [Caspar Fraxinus's papers].

    Science.gov (United States)

    Grynaeus, T; Vida, T

    1993-01-01

    These 21 unpublished letters written by, to or about Gaspar Fraxinus were collected by Istvan Botta, Tivadar Vida and Tamás Grynaeus. Most of the letters were actually health reports written by Fraxinus to Count Nadasdy, though the doctor mentions various other subjects as well. We have followed the Hungarian practice in the publication. The numbers that precede the letters refer to their original date and put them in concordance with all the known Fraxinus letters. Where you find question marks with the numbers the exact date of the letter is uncertain. After the numbers there are also short summaries, and then comes the letter itself in its original language and spelling. Letters either in Latin or German have been translated into Hungarian by Tivadar Vida, and those written in old Hungarian were provided with a transcription that gives the modern spelling. Each unit is closed with the archival data: i.e. the name of the institution that has been trusted with the preservation, and the shelfmarks are indicated.

  20. A multi-isotope approach to understanding the evolution of Cenozoic magmatism in the northeastern Basin and Range: Results from igneous rocks in the Albion-Raft River-Grouse Creek metamorphic core complex

    Science.gov (United States)

    Konstantinou, A.; Strickland, A.; Miller, E. L.

    2012-12-01

    Deep crustal rocks exposed by extensional processes in metamorphic core complexes provide a unique opportunity to address the magmatic and isotopic evolution of the crust and assess the relative crust versus mantle contributions in Cenozoic igneous rocks exposed in the complexes. The Albion-Raft River-Grouse Creek metamorphic core complex exposes mid-crustal rocks that resided at depths of ~15-20 km before the onset of Cenozoic extension. Three major Cenozoic magmatic events are represented in the complex and have been studied using multiple isotopic systems (whole rock Sr and Nd coupled with the Oxygen isotopes in zircon). These three major events are: (1) 42-31 Ma intrusion of a composite plutonic complex of calc-alkaline composition that intrudes both upper crustal rocks (~5-10 km depth) and deeper rocks. (2) A 32-25 Ma plutonic complex, with evolved calc-alkaline composition that intruded in the middle crust (~12-15 km depth), and (3) A 10-8 Ma bimodal (basalt-rhyolite) suite of volcanic rocks that contain high-T anhydrous mineral assemblages erupted across the complex. The pre-extensional crust consisted of an upper crust composed primarily of Neoproterozoic through Triassic metasedimentary rocks (schist and quartzite at its base and limestone at its top). The middle crust consists of late Archean orthogneiss with evolved composition (metamorphosed peraluminous granite) with average 87Sr/86Sr40~0.800, ɛNd40~ -43.4 and δ18Ozirc ~5.7‰. The lower crust is inferred to have been composed of Precambrian intermediate composition igneous rocks with average 87Sr/86Sr40~0.750, ɛNd40~ -37.5 and δ18Ozirc ~5.9‰, and Precambrian mafic rocks with average 87Sr/86Sr40~0.717, ɛNd40~ -25 and δ18Ozirc ~7.0‰. Existing and new data indicate that the 42-31 Ma upper crustal plutonic complex ranges in isotopic composition from 87Sr/86Sri=0.709-0.712, ɛNdi=-15 to -25 and δ18Ozirc 4.7-6.5‰. The composition of the 32-25 Ma middle crustal plutonic complex ranges from 87Sr

  1. Ethics and American Power: Speeches by Caspar W. Weinberger and George P. Shultz. Responses by Philip Geyelin, Smith Hempstone, Carl F. H. Henry, Thomas Molnar, Richard John Neuhaus, David D. Newsom, William V. O'Brien, Paul Seabury, Roger L. Shinn, Seymour Siegel, Edward Teller, Richard M. Nixon. Ethics and Public Policy Essay 59.

    Science.gov (United States)

    Lefever, Ernest W., Ed.

    Two cabinet secretaries address the problems of when and how the United States should use military power. Secretary of Defense Caspar W. Weinberger emphasizes the importance of prudence and restraint in the use of military force in chapter 1: "The Uses of Military Power." Secretary of State George P. Shultz stresses the vital importance…

  2. Clinical experience in 115 patients with arthritis and/or enthesitis who met the classification criteria for psoriatic arthritis (CASPAR) within the last two years-Possible association with malignant disorders.

    Science.gov (United States)

    Hagiwara, Kiyofumi; Suyama, Yasuhiro; Fukuda, Kunihiko

    2016-07-01

    Among about 400 patients with active arthritis and/or enthesitis who were referred to our department within the last two years, 140 of them were strongly suspected as having psoriatic arthritis by a comprehensive diagnostic procedure and after consulting specialists from dermatology, orthopedics, and radiodiagnostics at our institution and other institutions. Among them, 115 patients strictly met the classification criteria for psoriatic arthritis (CASPAR). Among the 115 patients, 19 patients (9 males and 10 females) had current psoriasis and 96 patients (22 males and 74 females) did not have current psoriasis. Nineteen (16.5%) of the 115 patients had developed malignant tumor before the onset of arthritis, and 4 (3.5%) developed malignant tumor after the onset of arthritis. Twenty-two of the 23 patients who developed malignancy were female and 10 patients developed breast cancer. Differential diagnoses in these 23 patients may include paraneoplastic syndrome. We consider that it is important to take into account the possibility of paraneoplastic syndrome in patients with arthritis and/or enthesitis who apparently meet the CASPAR criteria, and detailed screening and monitoring of malignant disease may be beneficial to the patients.

  3. [Caspar Friedrich Wolff: the emergence of epigenesis].

    Science.gov (United States)

    Muzrukova, E B; Pomelova, M A

    2015-01-01

    The role of C.F. Wolff, an outstanding anatomist and embryologist, in the development of embryology is described to mark the 280th anniversary of his birth. His life and work were fully elucidated in the book of A.E. Gaisinovich, a famous historian of biology. Although the alternation of preformation and epigenesis is accompanied by a succession of ideas, the boundary between these concepts is clearly retained and depends on many social and cultural factors.

  4. North Fork Caspar Creek stream biology study

    Science.gov (United States)

    Micheal S. Parker

    1991-01-01

    Timber harvesting is one of the most widespread land-uses in forested watersheds throughout western North America. It has long been recognized that timber removal, primarily through clearcutting, may have significant impacts on some environmental conditions within streams draining forested watersheds. It is also clear that logging related impacts are highly variable...

  5. Caspar Wessel on representing complex numbers (1799)

    DEFF Research Database (Denmark)

    Branner, Bodil

    1999-01-01

    In celebration of the bicentenary of the publication of Wessel's paper on the geometric interpretation of complex numbers it is decsribed how Wessel used complex numbers to represent directions in surveying, at least as early as 1787.......In celebration of the bicentenary of the publication of Wessel's paper on the geometric interpretation of complex numbers it is decsribed how Wessel used complex numbers to represent directions in surveying, at least as early as 1787....

  6. From Albion's shore: Lord Byron' poetry in Slovene translations until 1945

    Directory of Open Access Journals (Sweden)

    Igor Maver

    1989-12-01

    Full Text Available The publication in 1830 of the early poems of the doyen of Slovene poetry - Dr France Prešeren  in Kranjska čbelica (The Carniola Bee - marks the beginning of Slovene Romanticism, which ends in 1848, -with the last of his poems published in the fifth volume of the same literary magazine. The period from 1830 to the »revolutionary« year of 1848 is thus committed to Romanticism as the leading movement of Slovene literature, artfully embodied in Prešeren's fine lyrical poetry that aimed at and considerably contributed to national unification and identification, as well as in the Europe-oriented literary criticism of Matija čop.  Comparing the trends of the English and Slovene Romantic Revival, we can readily establish that the emergence of Romantic tenets expressed in poetry was somewhat late on Slovene ground. In England, of course, the crucial years are1789, when Lyrical Ballads were published by Wordsworth and Coleridge, and the year 1832, which marks the death of Sir Walter Scott.

  7. Parimad õppijad on Tallinna 21. keskkoolis / intervjueerinud Caspar Saar

    Index Scriptorium Estoniae

    2004-01-01

    Õpioskuste olümpiaadil saavutas võidu Tallinna 21. keskkooli kuuendate klasside õpilastest koosnev võistkond. Intervjuu võitjavõistkonna liikmete Heleni, Liisi, Cätlyn-Marylini ja Liisa-Helenaga, juhendaja oli õpetaja Sanne Haab

  8. Access and Use of Federal Data through NSF's CASPAR System.

    Science.gov (United States)

    Firnberg, James W.

    1991-01-01

    The National Science Foundation's Computer-Aided Science Policy and Research database system provides microcomputer-based access and manipulation of multiple national databases for federal and now institutional use. Applications at West Virginia University, Portland State University, and the State University of New York at Buffalo pilot tested the…

  9. "ta surnud sõbrad..." : [luuletused] / Caspar Tops

    Index Scriptorium Estoniae

    Tops, Caspar

    2002-01-01

    Autorist lk 133. Sisu: "ta surnud sõbrad..." ; "ta kummaline hüüd..." ; "nii salakaval oli üks naine..." ; "ta tõmbas..." ; "mul meeles üks..." ; "rohi saab lahti iga päev üha..." ; "aeg riietab end lahti..." ; "ta kunagi..." ; "me riietume..." ; "ma tean armastuse põsepuna..." ; "kunas see suudlus..." ; "sina mu mälestuste tydruk..." ; "su õde mind armastas..." ; "hingata valutult..." ; "need juuksed pesemata..." ; "ah saab olema..." ; "siit natuke maad edasi..."

  10. Das Eismeer – Caspar David Friedrich and the North

    Directory of Open Access Journals (Sweden)

    Nina Hinrichs

    2008-02-01

    1840 created the work of art Das Eismeer in the years 1823/24. Besides his painting Mönch am Meer it is his most radical painting. It depicts a dramatic and grim subject: A shipwreck in the Arctic Sea. According to different cultural, historical and social contexts there have been many different interpretations of his painting since it was produced.

  11. "ta surnud sõbrad..." : [luuletused] / Caspar Tops

    Index Scriptorium Estoniae

    Tops, Caspar

    2002-01-01

    Autorist lk 133. Sisu: "ta surnud sõbrad..." ; "ta kummaline hüüd..." ; "nii salakaval oli üks naine..." ; "ta tõmbas..." ; "mul meeles üks..." ; "rohi saab lahti iga päev üha..." ; "aeg riietab end lahti..." ; "ta kunagi..." ; "me riietume..." ; "ma tean armastuse põsepuna..." ; "kunas see suudlus..." ; "sina mu mälestuste tydruk..." ; "su õde mind armastas..." ; "hingata valutult..." ; "need juuksed pesemata..." ; "ah saab olema..." ; "siit natuke maad edasi..."

  12. Precommercial Stocking Control of Coast Redwood at Caspar Creek, Jackson Demonstration State Forest

    Science.gov (United States)

    James Lindquist

    2007-01-01

    Regeneration of coast redwood by stump sprouting often results in a stand condition that is very dense. A precommercial thinning of redwood sprouts allows managers to select trees and spacing that can best utilize the productivity of the site. The study of five thinning treatments with an unthinned control was initiated on a 19-year old third growth stand. Treatments...

  13. Logging Effects on Streamflow: Storm Runoff at Caspar Creek in Northwestern California

    Science.gov (United States)

    Wright, Kenneth A.; Sendek, Karen H.; Rice, Raymond M.; Thomas, Robert B.

    1990-07-01

    The effects of road building and selective tractor harvesting on storm runoff were assessed for a small (424 ha) coastal watershed in northern California. Road building alone did not significantly affect the storm runoff. After road building and logging, lag time was decreased approximately 1.5 hours, and the very small storm volumes (less than 1209 m3) and storm peaks (less than 566 L/s) were increased by about 132 and 111%, respectively. Storm volumes and peaks of large storms (occurring less frequently than eight times a year) were not significantly increased by either roads or logging, even though more than 15% of the watershed was compacted in roads, skid trails, and landings. Although a decrease in lag time showed that the average storm hydrograph was shifted forward in time, only the small storm hydrographs were changed in shape. We speculate that the rate of delivery of water to the stream channel during large channel-forming flows was governed by infiltration and subsurface flow rates on the 85% of the watershed that was unaffected by roads, landings, or skid trails. From these findings we conclude that, in a rain-dominated hydrologic environment, logging and forest road construction (as carried out in this study) are not likely to change the flow regime of a stream adversely.

  14. TYPE STUDIES IN THE CLAVARIOID FUNGI. V. THE TAXA DESCRIBED BY CASPAR VAN OVEREEM

    Directory of Open Access Journals (Sweden)

    RONALD H. PETERSEN

    1980-03-01

    Full Text Available ABSTRACTiType specimens of Javanese clavarias described by van Overeem —.e. Clavaria depokensis. Clavaria luteo-tenerrima, Clavaria sanguineo-acutaand Clavulinopsis sulcata — are extant and well preserved in HerbariumBogoriense. These are reexamined and reassigned to their respectivegenera and infrageneric complexes.

  15. Seismic data acquisition at the FACT site for the CASPAR project.

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Kyle R.; Chael, Eric Paul; Hart, Darren M.

    2012-01-01

    Since May 2010, we have been recording continuous seismic data at Sandia's FACT site. The collected signals provide us with a realistic archive for testing algorithms under development for local monitoring of explosive testing. Numerous small explosive tests are routinely conducted around Kirtland AFB by different organizations. Our goal is to identify effective methods for distinguishing these events from normal daily activity on and near the base, such as vehicles, aircraft, and storms. In this report, we describe the recording system, and present some observations of the varying ambient noise conditions at FACT. We present examples of various common, non-explosive, sources. Next we show signals from several small explosions, and discuss their characteristic features.

  16. Twenty-four near-instabilities of Caspar-Klug viruses

    Science.gov (United States)

    Englert, François; Peeters, Kasper; Taormina, Anne

    2008-09-01

    Group theoretical arguments combined with normal mode analysis techniques are applied to a coarse-grained approximation of icosahedral viral capsids which incorporates areas of variable flexibility. This highlights a remarkable structure of the low-frequency spectrum in this approximation, namely, the existence of a plateau of 24 near zero modes with universal group theory content.

  17. Computer-assisted scan protocol and reconstruction (CASPAR)-reduction of image noise and patient dose.

    Science.gov (United States)

    Sperl, Jonathan; Beque, Dirk; Claus, Bernhard; De Man, Bruno; Senzig, Bob; Brokate, Martin

    2010-03-01

    X-ray computed tomography is a powerful medical imaging device. It allows high-resolution 3-D visualization of the human body. However, one drawback is the health risk associated with ionizing radiation. Simply downscaling the radiation intensities over the entire scan results in increased quantum noise. This paper proposes the concept of computer-assisted scan protocol and reconstruction. More specifically, we propose a method to compute patient and task-specific intensity profiles that achieve an optimal tradeoff between radiation dose and image quality. Therefore, reasonable image variance and dose metrics are derived. Conventional third-generation systems as well as inverted geometry concepts are considered. Two dose/noise minimization problems are formulated and solved by an efficient algorithm providing optimized milliampere (mA)-profiles. Thorax phantom simulations demonstrate the promising advantage of this technique: in this particular example, the dose is reduced by 53% for third-generation systems and by 86% for an inverted geometry in comparison to a sinusoidal mA-profile at a constant upper noise limit.

  18. Developing CASPAR: a computer-assisted system for patient assessment and referral.

    Science.gov (United States)

    Gurel, Ozge; Carise, Deni; Kendig, Connie; McLellan, A Thomas

    2005-04-01

    A study was completed on the use of a computer-based system that provided counselors with resources for client referrals to free or low-cost services within the community based on problems identified with an Addiction Severity Index (ASI) assessment. That study, completed in Philadelphia, found that in comparison with clients whose counselors received a standard ASI assessment training, clients whose counselors also received brief training on the simple, easy-to-use computer-based resource guide (RG) had treatment plans that were substantially better-matched to their presenting problems and received significantly more and better-matched services. Because of these favorable results, the current article presents further data on counselor use of the RG and, to facilitate the implementation of these procedures by others, we provide access to the original RG database, describe the steps necessary to develop, and maintain an RG, and provide training suggestions.

  19. The Caspar microsurgical discectomy and comparison with a conventional standard lumbar disc procedure.

    Science.gov (United States)

    Caspar, W; Campbell, B; Barbier, D D; Kretschmmer, R; Gotfried, Y

    1991-01-01

    The outcome in 119 patients who were operated on with a conventional standard lumbar discectomy procedure was retrospectively compared with that in 299 patients who were operated on with a microsurgical discectomy technique developed in Homburg/Saar, Federal Republic of Germany by the senior author (W.C.). All patients in this consecutive series had "virgin" lumbar radiculopathy evaluated and operated upon by two experienced surgeons at one institution. Determination of the final outcome was made objectively by an impartial third party using identical criteria for both groups, and with a patient self-evaluation form. The study looked at various pertinent aspects of the treatment course and at final outcome. The results in the microsurgical group were significantly favorable: fewer levels were explored: there was less operative blood loss and a decreased incidence of deep venous thrombosis, urinary tract infections, pulmonary emboli, and bladder catheterization; the time to full ambulation, discharge, and return to work was faster: and there was a decrease in change of occupation and a greater percentage of satisfactory final outcomes, as measured both objectively and subjectively. A description of the microsurgical technique used in this study, which differs significantly from existing microdisectomy techniques, is presented. The authors conclude that the microsurgical disectomy technique presented in this study is a safe and effective approach to the treatment of lumbar radiculopathy.

  20. Logging Effects on Streamflow: Water Yield and Summer Low Flows at Caspar Creek in Northwestern California

    Science.gov (United States)

    Keppeler, Elizabeth T.; Ziemer, Robert R.

    1990-07-01

    Streamflow data for a 21-year period were analyzed to determine the effects of selective tractor harvesting of second-growth Douglas fir and redwood forest on the volume, timing, and duration of low flows and annual water yield in northwestern California. The flow response to logging was highly variable. Some of this variability was correlated with antecedent precipitation conditions. Statistically significant increases in streamflow were detected for both the annual period and the low-flow season. Relative increases in water yield were greater for the summer low-flow period than for annual flows, but these summer flow increases generally disappeared within 5 years.

  1. Palmse mõis / Johann Caspar Mohr, Aarne Kann, Leila Pärtelpoeg

    Index Scriptorium Estoniae

    Mohr, Johann Caspar (?-1788)

    1996-01-01

    Esimesed kirjalikud teated mõisa kohta pärinevad 1348. aastast. Omanik von Pahlen. (W. S. Stavenhageni terasegravüür 1866-1867. a.). lk. 74 (Oruveski, postkaart a. 1910), värv., lk. 75 (mõisahoone ja suur kaskaad, postkaardid a. 1910), värv., lk. 76 (mõisahoone pärast restaureerimist 1980-ndatel aastatel), värv., lk. 77 (härrastemaja tagakülg), värv., lk. 78 (park tiigi, paadisilla ja teemajaga), värv., lk. 79 (fragment 1753. a. plaanist ; vaade parki), värv., lk. 80-83 (restaureeritud siseruumid), värv., lk. 84 (park, paviljonid, 'Suur sild'), värv., lk. 85 (kasvuhoone), värv.

  2. 27 CFR 9.53 - Alexander Valley.

    Science.gov (United States)

    2010-04-01

    ... on the northeasterly line of “Olive Hill” Cemetery, lying on the easterly side of a light-duty road... most easterly point thereon; (17) Then southerly 3,000 feet along the meanders of the west fork of Wood... identified as Lytton Springs Road in T. 9 N., R. 9 W.; (21) Then easterly along Lytton Springs Road to...

  3. Getting patients the services they need using a computer-assisted system for patient assessment and referral—CASPAR

    Science.gov (United States)

    Carise, Deni; Gűrel, Ozge; McLellan, A. Thomas; Dugosh, Karen; Kendig, Connie

    2009-01-01

    The two goals of this technology transfer study were to: (1) increase the number and appropriateness of services received by substance abuse patients, and thereby (2) give clinical meaning and value to research-based assessment information. A software-based Resource Guide was developed to allow counselors to easily identify local resources for referral of their patients to additional clinical and social services. Two hours of training were provided on the use of the guide. It was hoped that this software and training would provide the counselors with a concrete method of linking the Addiction Severity Index (ASI) assessment information on patient problems to appropriate, available community services. We expected improved treatment planning, increased problem services matching, better patient–counselor rapport/satisfaction and better patient-performance during treatment. Data were analyzed from 131 patients of 33 counselors from 9 treatment programs, randomly assigned to 2 groups—Standard Assessment (SA) or Enhanced Assessment (EA). Patients of counselors in the EA group (1) had treatment plans that were better matched to their needs, (2) received significantly more and better-matched services than patients in the SA group, and (3) were less likely to leave treatment against medical advice and more likely to complete the full course of treatment than patients of counselors in the SA group. They did not have higher levels of patient satisfaction or helping alliance scores. These findings are discussed with regard to integrating empirically supported procedures into contemporary, community-based substance abuse treatment. PMID:15913922

  4. Biomechanical comparison of anterior Caspar plate and three-level posterior fixation techniques in a human cadaveric model.

    Science.gov (United States)

    Traynelis, V C; Donaher, P A; Roach, R M; Kojimoto, H; Goel, V K

    1993-07-01

    Traumatic cervical spine injuries have been successfully stabilized with plates applied to the anterior vertebral bodies. Previous biomechanical studies suggest, however, that these devices may not provide adequate stability if the posterior ligaments are disrupted. To study this problem, the authors simulated a C-5 teardrop fracture with posterior ligamentous instability in human cadaveric spines. This model was used to compare the immediate biomechanical stability of anterior cervical plating, from C-4 to C-6, to that provided by a posterior wiring construct over the same levels. Stability was tested in six modes of motion: flexion, extension, right and left lateral bending, and right and left axial rotation. The injured/plate-stabilized spines were more stable than the intact specimens in all modes of testing. The injured/posterior-wired specimens were more stable than the intact spines in axial rotation and flexion. They were not as stable as the intact specimens in the lateral bending or extension testing modes. The data were normalized with respect to the motion of the uninjured spine and compared using repeated measures of analysis of variance, the results of which indicate that anterior plating provides significantly more stability in extension and lateral bending than does posterior wiring. The plate was more stable than the posterior construct in flexion loading; however, the difference was not statistically significant. The two constructs provide similar stability in axial rotation. This study provides biomechanical support for the continued use of bicortical anterior plate fixation in the setting of traumatic cervical spine instability.

  5. Getting patients the services they need using a computer-assisted system for patient assessment and referral--CASPAR.

    Science.gov (United States)

    Carise, Deni; Gurel, Ozge; McLellan, A Thomas; Dugosh, Karen; Kendig, Connie

    2005-11-01

    The two goals of this technology transfer study were to: (1) increase the number and appropriateness of services received by substance abuse patients, and thereby (2) give clinical meaning and value to research-based assessment information. A software-based Resource Guide was developed to allow counselors to easily identify local resources for referral of their patients to additional clinical and social services. Two hours of training were provided on the use of the guide. It was hoped that this software and training would provide the counselors with a concrete method of linking the Addiction Severity Index (ASI) assessment information on patient problems to appropriate, available community services. We expected improved treatment planning, increased problem services matching, better patient-counselor rapport/satisfaction and better patient-performance during treatment. Data were analyzed from 131 patients of 33 counselors from 9 treatment programs, randomly assigned to 2 groups--Standard Assessment (SA) or Enhanced Assessment (EA). Patients of counselors in the EA group (1) had treatment plans that were better matched to their needs, (2) received significantly more and better-matched services than patients in the SA group, and (3) were less likely to leave treatment against medical advice and more likely to complete the full course of treatment than patients of counselors in the SA group. They did not have higher levels of patient satisfaction or helping alliance scores. These findings are discussed with regard to integrating empirically supported procedures into contemporary, community-based substance abuse treatment.

  6. Effects of timber harvesting on the lag time of a Caspar Creek watershed...a study in progress

    Science.gov (United States)

    Karen D. Hardison

    1982-01-01

    Researchers are not agreed on the effects of logging on lag time. Numerous studies have shown that the use of heavy equipment in logging operations can cause soil compaction. Also, associated roads alter natural drainage patterns by concentrating runoff and interrupting subsurface flow. As a result these researchers say, less infiltration into the soil takes place...

  7. "Investigations of salmon and steelhead trout downstream migrations in Caspar Creek and Little River, Mendocino County, March-July, 1993"

    Science.gov (United States)

    Albert Rodriguez; Weldon Jones

    1993-01-01

    Abstract - This annual study has been conducted, since 1987, on two coastal streams, in order to observe the different trend patterns of juvenile out migrations for coho salmon and steelhead-trout, figure 1. Analysis of the 1993 trapping season indicates, at Little River, a decrease of steelhead-trout yearlings but an increase in coho ""y+"". Coho...

  8. A Novel of Reviving a "Dead City"——《The Last Days of Pompeii》Written by Edward George Earl Bulwer Lytton%一部将"死城"复活的小说——爱德华·鲍沃尔·李敦《庞贝城的末日》

    Institute of Scientific and Technical Information of China (English)

    陈晓兰

    2008-01-01

    英国作家爱德华·鲍沃尔·李敦的历史传奇小说,描绘了罗马鼎盛时期的庞贝城,通过城市物质空间及在这一空间中活动着的高贵的和卑贱的生命的故事,复活了一座埋葬了1700多年的古城,向现代人展现了这座城市的风俗习惯、宗教文化以及它所遭遇的一场巨大而可怕的灾难.

  9. Scientific evaluation of Charles Dickens

    OpenAIRE

    Simkin, M. V.

    2009-01-01

    I report the results of the test, where the takers had to tell the prose of Charles Dickens from that of Edward Bulwer-Lytton, who is considered by many to be the worst writer in history of letters. The average score is about 50%, which is on the level of random guessing. This suggests that the quality of Dickens' prose is the same as of that of Bulwer-Lytton.

  10. Forskningen og Forsynet. Religion og videnskab i det efterreformatoriske Danmark

    DEFF Research Database (Denmark)

    Fink-Jensen, Morten

    2003-01-01

    Historie, Reformationen, Danmarks historie 1536-1660, Kirkehistorie, Videnskabshistorie, Tycho Brahe, Caspar Bartholin, Jens Skjelderup, Magi, Religion......Historie, Reformationen, Danmarks historie 1536-1660, Kirkehistorie, Videnskabshistorie, Tycho Brahe, Caspar Bartholin, Jens Skjelderup, Magi, Religion...

  11. GenBank blastn search result: AK318517 [KOME

    Lifescience Database Archive (English)

    Full Text Available son Copia WIS-1, complete sequence; transposon Caspar-1, partial sequence; transposon Hades-1, retrotranspos...on Veju-1, and transposon Caspar-2, complete sequence; transposon Hades-2, partial sequence; transposon Orph

  12. "From la Malinche and Menchu to Modern-Day "Mayas": Women Forging Paths through the Maze of Higher Education"

    Science.gov (United States)

    Hall, Vickie A.

    2010-01-01

    "Beneath the rule of men entirely great, the pen is mightier than the sword." Bulwer-Lytton recognized this strength years ago, and its truth continues to ring true in the works of authors: Tzvetan Todorov, Octavio Paz, Carlos Fuentes, Rigoberta Menchu, and Deborah Tannen. Language is a centuries-old weapon wielded in the struggle against…

  13. Vastuolud annavad märku muutuste vajadusest / Marit Pukk

    Index Scriptorium Estoniae

    Pukk, Marit

    2002-01-01

    Kiiresti areneva firma struktuur vajab muutmist. Kommenteerivad gasellettevõtete juhid Argo Schneider (OÜ Albion Reisid), Peep Nork (AS Euro Truck Trade Center), Riinu Värk (AS Meditsiinigrupp) ja Tiit Elenurm

  14. Accretionary Lapilli (Carbonate Spherules) at the Cretaceous-Paleogene ('KT') Boundary in Belize (Central America)

    Science.gov (United States)

    King, D. T.; Petruny, L. W.

    2013-08-01

    The Chicxulub impact event produced accretionary lapilli (or carbonate spherules) that fell across a wide area. This paper compares Chicxulub ('KT') accretionary lapilli from two sites in Belize: Albion Island and Armenia.

  15. Vastuolud annavad märku muutuste vajadusest / Marit Pukk

    Index Scriptorium Estoniae

    Pukk, Marit

    2002-01-01

    Kiiresti areneva firma struktuur vajab muutmist. Kommenteerivad gasellettevõtete juhid Argo Schneider (OÜ Albion Reisid), Peep Nork (AS Euro Truck Trade Center), Riinu Värk (AS Meditsiinigrupp) ja Tiit Elenurm

  16. Browse Title Index

    African Journals Online (AJOL)

    Items 3651 - 3700 of 11090 ... ... and plant regeneration from leaf explants of sugarcane (Saccharum sp.) ... with 1H-indole-3-butanoic acid (IBA) on Albion strawberry (Fragaria .... Effect of irrigation frequency and application levels of sulphur ...

  17. Adapting Coral Culture to Climate Change: The Mauritian Experience

    African Journals Online (AJOL)

    land-based nursery (LBN) and ocean-based nursery (OBN) in 2008-2010 at Albion,. Mauritius. Survival .... addition, water recycled continuously through ... glue, MAGPOW, Japan) to plastic nails .... chemical variables were initially recorded in.

  18. Distribution and Abundance of the Sponge Spheciospongia ...

    African Journals Online (AJOL)

    vagabunda (Ridley, 1884) was investigated in a shallow lagoon (Albion) of ... Clionaidae) found in coastal lagoons (Levi, ... depends on a number of physical and biological .... Statistical analyses .... Patch 1 and may be another factor that.

  19. Report of the Secretary of Defense Caspar W. Weinberger to the Congress on the FY 1987 Budget, FY 1988 Authorization Request and FY 1987-1991 Defense Programs, February 5, 1986

    Science.gov (United States)

    1986-02-05

    replacement of the USS CORAL SEA, which will become the Navy’s training carrier, replacing the USS LEXINGTON. Looking ahead, the Navy will have to order... Marino Corps Tactical Support 44 44444 44 Reswerve Navy and Marine Corps Tactical Support 44 444 44 43 SeeM Ships. Active Tankers 21 21 26 26 24 Cargo 23

  20. Report of the Secretary of Defense Caspar W. Weinberger to the Congress on the FY 1988/FY 1989 Budget and FY 1988-92 Defense Programs, January 12, 1987.

    Science.gov (United States)

    1987-01-01

    the praise It won from the great English statesman, William Gladstone , as the "most wonderful work ever struck off at a given time by the brain and...growth to the already large stock of Soviet military assets (see Chart I.A.4). In 1984, for the first time since 1969 , U.S. military procurement appears...stability at lower force levels. Beginning in 1969 , the United States attempted to constrain the growth of the Soviet strategic threat through the Strategic

  1. Caspar型颈椎撑开器在颈椎间减压手术中的应用研究%The research of Caspar distractor for anterior cervical discectomy

    Institute of Scientific and Technical Information of China (English)

    袁峰; 杨惠林; 张志明; 殷骏; 姚飞荣

    2004-01-01

    目的:探讨使用Caspar型颈椎撑开器在颈前路椎间减压手术中对颈椎椎间角度、椎间孔大小的影响.方法:取10具C2~C7成人颈椎标本,将Caspar型颈椎撑开器的2枚固定螺钉分别在C4、C5椎体正中相互平行置人,按照Smith-Robinson手术方法进行C4/5间隙减压,用颈椎撑开器加压2mm和撑开2mm、4mm,分别在CR机上摄颈椎侧、斜位片,Pacsout程序软件测量C4/5椎间孔L面积和椎间角度,SAS 6.12软件包进行统计分析.结果:颈椎撑开器压缩2mm,椎间孔面积无明显改变,椎间角度减小39.7%;撑开2mm时,椎间孔面积增加28.3%,椎间角度增加67.6%;撑开4mm时,椎间孔面积增加33.3%,椎间角度增加136.8%.结论:颈椎撑开器撑开椎间隙时扩大了椎间孔面积,同时也增加了椎间角度;提示不应强求使用颈椎撑开器过度撑开椎间隙的方法来增加椎间孔面积.

  2. Museo de arte, en Los Ángeles, California (U.S.A.

    Directory of Open Access Journals (Sweden)

    Pereira, Willian L.

    1967-09-01

    Full Text Available This Museum involves three buildings, organised around a square, which has been carefully landscaped. The buildings are: the Ahmanson Gallery, the Lytton Gallery and the Leo S. Bing Center. This Museum, one of the largest in the United States, is outstanding because of the efficiency of its installations and attractively spectacular external aspect.Consta de tres edificios, organizados alrededor de una plaza central, que ha sido tratada paisajísticamente; dichos edificios son: la Galería Ahmanson, la Galería Lytton y el Leo S. Bing Center. Este Museo, uno de los mayores de los Estados Unidos, además de por la funcionalidad de sus instalaciones, destaca por su atrayente espectacularidad.

  3. Statistics against irritations: a response to Dickens's apologists

    CERN Document Server

    Simkin, M V

    2013-01-01

    In a recent article (arXiv:0909.2479) I reported the results of the test, where the takers had to tell the prose of Charles Dickens from the prose of Edward Bulwer-Lytton. The former is a required reading in school, and the latter has a bad writing contest named after him. Nevertheless, the test-takers performed on the level of random guessing. This research has met much criticism, which I refute the in the present article.

  4. Proceedings from the Workshop on Large-Grained Parallelism (2nd) Held in Hidden Valley, Pennsylvania on October 11-14, 1987.

    Science.gov (United States)

    1987-11-01

    Kingston, Ontario Canada K7L 3N6 , macewenqucis@wiscvm.wisc.edu .* Martin McKendry FileNet Corporation 3530 Hyland Avenue Costa Mesa, CA 92626 (hplabs...University Park, Pa16802, USA (814)863-0147 narayana@psuvatl .uucp The seminal paper by Hoare[S] on a notition for Communicatin , Sequential Processes...and John R. Ellis Digital Equipment Corporation Systems Research Center 130 Lytton Avenue Palo Alto, CA 94301 Large software systems are typically

  5. A Case Study of Liberal Arts Colleges in the 21st Century: Understanding Organizational Change and Evolution in Higher Education

    Science.gov (United States)

    Baker, Vicki L.; Baldwin, Roger G.

    2015-01-01

    We draw upon the evolutionary model of change in order to examine the organizational transformation of three liberal arts colleges (Albion College, Allegheny College, Kenyon College). Relying on our prior research (Baker, Baldwin, & Makker, 2012), we seek to continue our exploration and understanding of the evolution occurring in the important…

  6. Plaadid / Mart Normet

    Index Scriptorium Estoniae

    Normet, Mart, 1979-

    2006-01-01

    Uutest heliplaatidest J.M.K.E. "mälestusi Eesti NSV-st", Infadels "We Are Not The Infadels", Babyshambles "Down In Albion", Rigmor Gustafsson "On My Way To You", Mary J. Blige "The Breakthrough", Beck "Guerolito", Scala & Kolacny Brothers "Grenzenlos"

  7. The Folds of War: Blake’s Meaning of Warfare and Warfare of Meaning

    Science.gov (United States)

    1988-01-01

    Utopia predicated on change, a heaven pulsing with life, contracting and expanding, allowing for love and wrath, individuality and unity . . . [where...Saviour’s coming, saying: I feel my Spectre rising upon me! Albion! arouze thyself Thou wilt certainly provoke my Spectre against thine in fury! He has a

  8. Compariative analysis of strawberry total phenolics via fast blue BB vs. folin-ciocalteu: assay interference by ascorbic acid

    Science.gov (United States)

    Strawberry (Fragaria ×ananassa Duchesne ex Rozier) fruit were harvested from two field plots of five day-neutral cultivars: Albion, Monterey, Portola, San Andreas and Seacape. Marketable (salable) berries were harvested from each plot on 22 and 25 August, and unblemished fully ripe fruit were selec...

  9. Plaadid / Mart Normet

    Index Scriptorium Estoniae

    Normet, Mart, 1979-

    2006-01-01

    Uutest heliplaatidest J.M.K.E. "mälestusi Eesti NSV-st", Infadels "We Are Not The Infadels", Babyshambles "Down In Albion", Rigmor Gustafsson "On My Way To You", Mary J. Blige "The Breakthrough", Beck "Guerolito", Scala & Kolacny Brothers "Grenzenlos"

  10. 75 FR 68623 - Investigations Regarding Certifications of Eligibility To Apply for Worker Adjustment Assistance

    Science.gov (United States)

    2010-11-08

    ... substantial interest in the subject matter of the investigations may request a public hearing, provided such... regarding the subject matter of the investigations to the Director, Division of Trade Adjustment Assistance... Antenna Systems, Albion, MI 10/22/10 10/18/10 Inc. (Company). 74766 Rocon Manufacturing Rochester,...

  11. Transcriptome Characterization of Developing Bean (Phaseolus vulgaris L. Pods from Two Genotypes with Contrasting Seed Zinc Concentrations.

    Directory of Open Access Journals (Sweden)

    Carolina Astudillo-Reyes

    Full Text Available Dry bean (Phaseolus vulgaris L. seeds are a rich source of dietary zinc, especially for people consuming plant-based diets. Within P. vulgaris there is at least two-fold variation in seed Zn concentration. Genetic studies have revealed seed Zn differences to be controlled by a single gene in two closely related navy bean genotypes, Albion and Voyager. In this study, these two genotypes were grown under controlled fertilization conditions and the Zn concentration of various plant parts was determined. The two genotypes had similar levels of Zn in their leaves and pods but Voyager had 52% more Zn in its seeds than Albion. RNA was sequenced from developing pods of both genotypes. Transcriptome analysis of these genotypes identified 27,198 genes in the developing bean pods, representing 86% of the genes in the P. vulgaris genome (v 1.0 DOE-JGI and USDA-NIFA. Expression was detected in 18,438 genes. A relatively small number of genes (381 were differentially expressed between Albion and Voyager. Differentially expressed genes included three genes potentially involved in Zn transport, including zinc-regulated transporter, iron regulated transporter like (ZIP, zinc-induced facilitator (ZIF and heavy metal associated (HMA family genes. In addition 12,118 SNPs were identified between the two genotypes. Of the gene families related to Zn and/or Fe transport, eleven genes were found to contain SNPs between Albion and Voyager.

  12. Transcriptome Characterization of Developing Bean (Phaseolus vulgaris L.) Pods from Two Genotypes with Contrasting Seed Zinc Concentrations.

    Science.gov (United States)

    Astudillo-Reyes, Carolina; Fernandez, Andrea C; Cichy, Karen A

    2015-01-01

    Dry bean (Phaseolus vulgaris L.) seeds are a rich source of dietary zinc, especially for people consuming plant-based diets. Within P. vulgaris there is at least two-fold variation in seed Zn concentration. Genetic studies have revealed seed Zn differences to be controlled by a single gene in two closely related navy bean genotypes, Albion and Voyager. In this study, these two genotypes were grown under controlled fertilization conditions and the Zn concentration of various plant parts was determined. The two genotypes had similar levels of Zn in their leaves and pods but Voyager had 52% more Zn in its seeds than Albion. RNA was sequenced from developing pods of both genotypes. Transcriptome analysis of these genotypes identified 27,198 genes in the developing bean pods, representing 86% of the genes in the P. vulgaris genome (v 1.0 DOE-JGI and USDA-NIFA). Expression was detected in 18,438 genes. A relatively small number of genes (381) were differentially expressed between Albion and Voyager. Differentially expressed genes included three genes potentially involved in Zn transport, including zinc-regulated transporter, iron regulated transporter like (ZIP), zinc-induced facilitator (ZIF) and heavy metal associated (HMA) family genes. In addition 12,118 SNPs were identified between the two genotypes. Of the gene families related to Zn and/or Fe transport, eleven genes were found to contain SNPs between Albion and Voyager.

  13. 徘徊于坍塌上帝之所的颓废浪漫——解读浪漫主义风景画大师弗里德里希%The Decadent Romance which is Hanging about the House where the God Lives——The Horrible Aesthetic Effect in Caspar David Friedrich's Work

    Institute of Scientific and Technical Information of China (English)

    陈玮

    2007-01-01

    弗利德里希,是早期浪漫主义风景画的代表人物.他反对任何形式的传统.坚定个人内心情感的表达.他的风景画亲切而又神秘,始终显露出一种不安定的平衡感.他风景画中的人物常常是不重要的.画中主要描写的对象,如树林、废墟常以剪影的方式出现在雾霭的背景中,因此具有很强的恐怖美学效果和神秘主义的色彩,正因为如此.他的作品成为后世艺术家们赞叹和争论的话题.

  14. Two Academic Systems Introduced from Western Political Science in the Late Qing Period——Discussion Centering on Bluntchli Johann Caspar and Kiheiji Onozuka%晚清时期西方政治学引入的两种学术体系——以伯伦知理与小野塚喜平次为中心的讨论

    Institute of Scientific and Technical Information of China (English)

    王昆

    2016-01-01

    1899年4月,《清议报》刊载的伯伦知理《国家论》译著,是西方政治学作为一门独立学科在近代中国引入的滥觞.在此之后,各类政治学著述便开始在中国广泛传播,其中最主要的代表性著作即是小野塚喜平次的《政治学大纲》.伯伦知理与小野塚喜平次的相关著述,代表了这一时期引入的两种不同类型的政治学学术体系.前者建构的学术体系是以“国家”、“宪法”为基础,围绕与国家相关的诸问题形成的“国家学”学术框架.而在小野塚喜平次《政治学大纲》一书传入中国后,西方政治学的研究视野从理论层面拓展到了公民社会,并特别强调对政治现象的研究,提倡引入社会学、统计学、经济学等多种学科手段对政治学进行研究.这种变动与调整体现了政治学研究视野的扩展、研究体系的扩大与研究方法的扩充.

  15. Nano particles as the primary cause for long-term sunlight suppression at high southern latitudes following the Chicxulub impact - evidence from ejecta deposits in Belize and Mexico

    DEFF Research Database (Denmark)

    Vajda, Vivi; Ocampo, Adriana; Ferrow, Embaie;

    2015-01-01

    Life on Earth was sharply disrupted 66 Ma ago as an asteroid hit the sea-floor in what is today Yucatan Peninsula, Mexico. Approximately 600 km3 of sedimentary rock were vapourized, ejected into the atmosphere and subsequently deposited globally as an ejecta apron and fallout layer. Proximal ejecta...... deposits occur in Belize and southern Mexico where the so called Albion island spheroid bed is superimposed on the target rock (the Barton Creek Formation). We analysed the spheroid bed via Mössbauer spectroscopy, petrology, XRD, and palynology at several sites ~ 350-500 km distance from the crater centre....... Our results show that the relative concentrations of Fe in nano-phase goethite (α-FeOOH) are very high in the spheroid bed samples from Albion Island (Belize) and from Ramonal South (Mexico), but are low to absent in the spheroid bed at Ramonal North, and in the Cretaceous target rock. Moreover, our...

  16. Persistence of physics and engineering students via peer mentoring, active learning, and intentional advising

    Science.gov (United States)

    McCavit, K.; Zellner, N. E. B.

    2016-11-01

    Albion College, a private, undergraduate-only, liberal arts college in Michigan, USA, has developed and implemented a low-cost peer-mentoring programme that blends personal and academic support to help students achieve academic success in the introductory courses required for the Physics Major or the Dual-Degree Program in Engineering. This enhanced mentoring programme provides much-needed assistance for undergraduate students to master introductory physics and mathematics coursework, to normalise the struggle of learning hard material, and to accept their identity as physics or engineering students (among other goals). Importantly, this programme has increased retention among entering science, technology, engineering and mathematics students at Albion College as they move through the introductory classes, as shown by a 20% increase in retention from first-semester to third-semester physics courses compared to years when this programme was not in place.

  17. Chicxulub Ejecta Blanket Deposits From Belize

    Science.gov (United States)

    Ocampo, A.

    1995-01-01

    The Chicxulub impact into a thick sequence of carbonates and sulfates released over a trillion tons of volatiles. The importance of the explosive release of such a large mass of volatiles has been greatly underestimated in studies of ejecta depositional processes. Proximal Chicxulub ejecta blanket deposits recent discovered on Albion Island in Belize provide a key to understanding the role of volatile-rich target material during large impact events.

  18. Final Environmental Impact Statement. Permit Application by United States Steel Corp., Proposed Lake Front Steel Mill, Conneaut, Ohio. Volume 3.

    Science.gov (United States)

    1979-01-01

    interested in fishing may travel to the Grand River near Harpersfield and Austinburg, and for hunting, users may travel to the New Lyme and Orwell ...Pyiiatuning Reservoir Orwell , Ohio Grand River Tributary Albion, Pennsylvania East Branch of Conneaut Creek Waterford, Pennsylvania LeBoeuf Creek Union City...165 Westman, Quantifying Benefits of Pollution Control. 4-166 Personal Comnunication. Bob Wellington, Erie County Health Departent; George Holliday

  19. Development of a High Strength Isothermally Heat-Treated Nodular Iron Road Wheel Arm

    Science.gov (United States)

    1985-03-31

    Ductile Iron . ADI = Austempered Ductile I ron. 19. ABSTRACT (Continue on...Characterization. 23 HAYES-ALBION CORP AUSTEMPERED DUCTILE IRON 200 KSI loo0 U’T.S 20o 1 YIELD KS oo" 10_ 10 - S% * . " ’"ELONGATION E-. I 50 HARDNESS 300 FT.LBS...manufacture, and testing of a proposed road wheel arm for the Ml tank. The material selected is bainitic ductile iron (BDI). This material made by the

  20. Geologic Map and Digital Data Base of the Almo Quadrangle and City of Rocks National Reserve, Cassia County, Idaho

    Science.gov (United States)

    Miller, David M.; Armstrong, Richard L.; Bedford, David R.; Davis, Marsha

    2008-01-01

    This geologic map describes the geology of the City of Rocks National Reserve and environs, located in the Albion Mountains of south-central Idaho. The most prominent geologic features of the Reserve are the spectacular rock spires that attracted visitors, beginning with commentary in the journals of travelers to California during the Gold Rush of 1849. The tectonic history is outlined, and descriptions of landscape processes, a newly discovered Quaternary fault, and features of the pinnacles are presented.

  1. Bohemian mineralogy in the early 19th century: the Vaterländisches Museum in Böhmen

    NARCIS (Netherlands)

    Schweizer, C.R.

    2004-01-01

    The Vaterländisches Museum in Prague was officially founded in 1822 by Caspar and Franz Sternberg as a manifestation of Bohemian nationalism. It aimed at 1) the education of the public, 2) the sponsorship of Bohemian scientific and cultural research, and 3) the economical utilization of scientific

  2. Lavater ja Goethe / Linnar Priimägi

    Index Scriptorium Estoniae

    Priimägi, Linnar, 1954-

    2016-01-01

    Arvustus: Lavateri näoraamat : valgustusajastu pilk inimesele ja kunstile : toetudes Johann Caspar Lavateri menuteosele "Füsiognoomilisi fragmente inimesetundmise ja ligimesearmastuse edendamiseks" (1775-1778) / koostanud, kommenteerinud ja toimetanud Anu Allikvee ja Tiina-Mall Kreem ; fragmentide tõlge: Katrin Kaugver. Tallinn : Eesti Kunstimuuseum, Mikkeli Muuseum ; Tallinna Ülikool, Akadeemiline Raamatukogu. 2015

  3. 76 FR 44048 - Agency Information Collection Activities: Comment Request

    Science.gov (United States)

    2011-07-22

    ... the Web-based Computer-Aided Science Policy Analysis and Research (WebCASPAR) database system. The URL... extensively. The National Science Foundation and the National Institutes of Health, publishes statistics from... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE...

  4. Lavater ja Goethe / Linnar Priimägi

    Index Scriptorium Estoniae

    Priimägi, Linnar, 1954-

    2016-01-01

    Arvustus: Lavateri näoraamat : valgustusajastu pilk inimesele ja kunstile : toetudes Johann Caspar Lavateri menuteosele "Füsiognoomilisi fragmente inimesetundmise ja ligimesearmastuse edendamiseks" (1775-1778) / koostanud, kommenteerinud ja toimetanud Anu Allikvee ja Tiina-Mall Kreem ; fragmentide tõlge: Katrin Kaugver. Tallinn : Eesti Kunstimuuseum, Mikkeli Muuseum ; Tallinna Ülikool, Akadeemiline Raamatukogu. 2015

  5. Data on Second Majors in Language and Literature, 2001-13

    Science.gov (United States)

    Modern Language Association, 2015

    2015-01-01

    Data on second majors were added to the degree completions component of the United States Department of Education's Integrated Postsecondary Education Data System (IPEDS) in 2001 and were made available on the National Science Foundation's "WebCASPAR" Web site (https://webcaspar.nsf.gov/) in 2010. The Modern Language Association's first…

  6. Koers houden in turbulentie : De rol van de rijksoverheid op het gebied van infrastructuur en milieu internationaal vergeleken

    NARCIS (Netherlands)

    Berg, van den C.F.; Meer, van der F.M.; Mannekes, van M.; Osch, van D.; Porth, J.; Schmidt, A.

    2015-01-01

    Caspar van den Berg, Frits van der Meer, Marije van Mannekes, Danielle van Osch, Jan Porth en Arjen Schmidt hebben een omvangrijk internationaal-vergelijkend onderzoek uitgevoerd naar de veranderde rol van de overheid in België/Vlaanderen, Canada, Denemarken, Duitsland, Finland, Frankrijk en het Ver

  7. The botany of the Commelins

    NARCIS (Netherlands)

    Wijnands, D.O.

    1983-01-01

    The Botany of the Commelins deals with the plants pictured in the Moninckx Atlas and the four books by Jan and Caspar Commelin on the exotic plants in the Hortus Medicus of Amsterdam. Water-colours were painted of 420 plants during the years 1686-1709 by a number of artists,

  8. Habitat-dependent interactions between two size-classes of juvenile steelhead in a small stream

    Science.gov (United States)

    Bret C. Harvey; Rodney J. Nakamoto

    1997-01-01

    Abstract - The presence of small steelhead (Oncorhynchus mykiss; averaging 55 mm fork length) influenced the growth of larger juvenile steelhead (90 mm fork length) during a 6-week experiment conducted in North Fork Caspar Creek, California, in summer 1994. In fenced replicate deep stream sections in this small stream, growth of the larger steelhead was greater in...

  9. A hidden early source of information on north-eastern Brazilian zoology

    NARCIS (Netherlands)

    Boeseman, M.

    1994-01-01

    Attention is drawn to some hitherto overlooked paragraphs on the north-eastern Brazilian fauna hid- den in a historiographic account of Count Johan Maurits' govenorship (1637-1644), published by Caspar van Baerle (Barlaeus) in 1647, a year before the publication of Marcgrave & Piso's famous Historia

  10. Yield, quality and biochemical properties of various strawberry cultivars under water stress.

    Science.gov (United States)

    Adak, Nafiye; Gubbuk, Hamide; Tetik, Nedim

    2017-06-05

    Although strawberry (Fragaria x ananassa Duch.) species are sensitive to abiotic stress conditions, some cultivars are known to be tolerant to different environmental conditions. We examined the response of different strawberry cultivars to water stress conditions in terms of yield, quality and biochemical features. The trial was conducted under two different irrigation regimes: in grow bags containing cocopeat (control, 30%; water stress, 15% drainage) with four different cultivars (Camarosa, Albion, Amiga and Rubygem). Fruit weight declined by 59.72% and the yield per unit area by 63.62% under water stress conditions as compared to control. Albion and Rubygem were found to be more tolerant and Amiga the most sensitive in terms of yield under stress conditions. Water stress increased all biochemical features in fruits such as total phenol, total anthocyanin, antioxidant activity and sugar contents. Among the cultivars, glucose and fructose was higher in Albion. Considering the rise in global warming, identification of resistant and tolerant cultivars to stress conditions are crucial for future breeding programmes. Our results showed that some of the fruit's physical features were affected negatively by stress conditions whereas many of the biochemical features such as total anthocyanin content, total phenolic content and antioxidant activity were positively modulated. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  11. The dimensional accuracy of preparation of femoral cavity in cementless total hip arthroplasty

    Institute of Scientific and Technical Information of China (English)

    WU Li-dong (吴立东); HAHNE H.J.; HASSENPFLUG J.

    2004-01-01

    Objective: To observe the accuracy of femoral preparation and the position of the cementless prosthesis in femoral cavity, and to compare the results between the computer-assisted surgical group (CASPAR) and the conventional group. Methods: Ten femoral components were implanted either manually or by CASPAR in cadaver femurs. The specimens were cut to 3 mm thick slices. Microradiograms of every slice were sent to a computer for analysis with special software (IDL). The gaps and the medullary cavities between component and bone, the direct bone contact area of the implant surface,the gap width and the percentage of gap and bone contact area were measured in every slice. Results: In the proximal implant coated with HA of the CASPAR group, the average percentage of bone contact reached 93.2% (ranging from 87.6% to 99.7%); the average gap percentage was 2.9% (ranging from 0.3% to 7.8%); the maximum gap width was 0.81 mm and the average gap width was only 0.20 mm. While in the conventional group, the average percentage of bone contact reached 60.1% (ranging from 49.2% to 70.4%); the average gap percentage was 32.8% (ranging from 25.1% to 39.9%); the maximum gap width was 2.97 mm and the average gap width was 0.77 mm. The average gap around the implant in the CASPAR group was only 9% of that in the manual group; the maximum and average gap widths were only about 26% of those in the manual group. On the other hand, the CASPAR group showed 33% higher bone contact than the manual group. Conclusion: With the use of robotics-assisted system, significant progress can be achieved for femoral preparation in total hip arthroplasty.

  12. The dimensional accuracy of preparation of femoral cavity in cementless total hip arthroplasty

    Institute of Scientific and Technical Information of China (English)

    吴立东; HAHNEH.J.; HASSENPFLUGJ.

    2004-01-01

    Objective: To observe the accuracy of femoral preparation and the position of the cementless prosthesis in femoral cavity, and to compare the results between the computer-assisted surgical group (CASPAR) and the conventional group. Methods: Ten femoral components were implanted either manually or by CASPAR in cadaver femurs. The specimens were cut to 3mm thick slices. Microradiograms of every slice were sent to a computer for analysis with special software (IDL). The gaps and the medullary cavities between component and bone, the direct bone contact area of the implant surface, the gap width and the percentage of gap and bone contact area were measured in every slice. Results: In the proximal implant coated with HA of the CASPAR group, the average percentage of bone contact reached 93.2% (ranging from 87.6% to 99.7%); the average gap percentage was 2.9% (ranging from 0.3% to 7.8%); the maximum gap width was 0.81mm and the average gap width was only 0.20mm. While in the conventional group, the average percentage of bone contact reached 60.1% (ranging from 49.2% to 70.4%); the average gap percentage was 32.8% (ranging from 25.1% to 39.9%); the maximum gap width was 2.97mm and the average gap width was 0.77mm. The average gap around the implant in the CASPAR group was only 9% of that in the manual group; the maximum and average gap widths were only about 26% of those in the manual group. On the other hand, the CASPAR group showed 33% higher bone contact than the manual group. Conclusion: With the use of robotics-assisted system, significant progress can be achieved for femoral preparation in total hip arthroplasty.

  13. Chicxulub Impact Ejecta in Belize

    Science.gov (United States)

    Ocampo, A.; Pope, K.; Fischer, A.; Alvarez, W.; Fouke, B.; Asaro, F.; Webster, C., Jr.; Vega, F.; Smith, J.; Fritsche, A. E.

    1997-01-01

    Chicxulub ejecta deposits in Belize provide the closest exposures of ejecta to the crater and the only exposures of proximal ejecta deposited in a terrestrial environment. A quarry on Albion Island in northern Belize exposes Late Cretaceous, possibly Maastrichtian, carbonate platform sediments that were folded, eroded, and subaerially weathered prior to the deposition of coarse ejecta from Chicxulub. These ejecta deposits are composed of a basal, about 1-m-thick clay and dolomite Spheroid Bed overlain by a about 15-m-thick coarse Diamictite Bed. Many and perhaps most of the clay spheroids are altered glass. Many dolomite spheroids have concentric layers and angular cores are probably of accretionary lapilli origin. A slight Ir concentration (111-152 ppt) was detected in the base of the Spheroid Bed. The Diamictite Bed contains about 10% altered glass, rare shocked quartz, 3-8 m diameter boulders and striated and polished cobbles, one with a penetrating rock chip that plastically deformed the cobble. Ejecta deposits extend to the surface at Albion and the maximum thickness in this area is not known. Ejecta deposits are exposed in several roadside quarries in the Cayo District of central Belize. The Late Cretaceous here is also represented by carbonate platform sediments. The upper surface of the carbonate platform is a highly irregular and extensively recrystallized horizon possibly representing deep karst weathering. Approximately 30 in of diamictite overlies this horizon with a texture similar to the Diamictite Bed at the Albion quarry, but with a more diverse lithology. In three locations the Cayo diamictites, contain red clay layers with abundant polished and striated limestone pebbles and cobbles called Pook's Pebbles, several of which have penetrating rock chips and ablated surfaces. We interpret the Albion Spheroid Bed as a deposit from the impact vapor plume and the Albion and Cayo diamictites as the result of a turbulent flow that contained debris derived

  14. En gave til skolernes litteraturundervisning

    DEFF Research Database (Denmark)

    Larsen, Peter Stein

    2015-01-01

    Mens Caspar Erics debutdigtsamling, " 7/ 11", fra sidste år var præget af en stil, hvor der i en hæsblæsende strøm blev refereret til Facebook, You-Tube, iPhone, mp3, Macbook, Twitter og Netflix, frem for at man fik noget at vide om, hvad der rørte sig i ... ......Mens Caspar Erics debutdigtsamling, " 7/ 11", fra sidste år var præget af en stil, hvor der i en hæsblæsende strøm blev refereret til Facebook, You-Tube, iPhone, mp3, Macbook, Twitter og Netflix, frem for at man fik noget at vide om, hvad der rørte sig i ... ...

  15. Web-based diagnosis and therapy of auditory prerequisites for reading and spelling

    Directory of Open Access Journals (Sweden)

    Krammer, Sandra

    2006-11-01

    Full Text Available Cognitive deficits in auditory or visual processing or in verbal short-term-memory are amongst others risk factors for the development of dyslexia (reading and spelling disability. By early identification and intervention (optimally before school entry, detrimental effects of these cognitive deficits on reading and spelling might be prevented. The goal of the CASPAR-project is to develop and evaluate web-based tools for diagnosis and therapy of cognitive prerequisites for reading and spelling, which are appropriate for kindergarten children. In the first approach CASPAR addresses auditory processing disorders. This article describes a computerized and web-based approach for screening and testing phoneme discrimination and for promoting phoneme discrimination abilities through interactive games in kindergarteners.

  16. Kirjandus- ja kultuuritegelased Pärnu Alevi kalmistul / Gerda Kuum

    Index Scriptorium Estoniae

    Kuum, Gerda

    2007-01-01

    Jutukirjanik Suve Jaan, kodanikunimega Sommer Johann Friedrich (1777-1851); baltisaksa kirjamees ja pastor Johann Heinrich Rosenplänter (1782-1846); kirjamees ja köster Caspar Franz Lorenzsonn (1811-1880); köster Heinrich Gottlieb Lorenzsonn (1803-1847); trükkal ja kirjastaja Friedrich Wilhelm Bonn (1812-1881); linnapead Oskar Alexander Brackmann (1841-1927) ja Jaan Leesment (1870-1941)

  17. Kirjandus- ja kultuuritegelased Pärnu Alevi kalmistul / Gerda Kuum

    Index Scriptorium Estoniae

    Kuum, Gerda

    2007-01-01

    Jutukirjanik Suve Jaan, kodanikunimega Sommer Johann Friedrich (1777-1851); baltisaksa kirjamees ja pastor Johann Heinrich Rosenplänter (1782-1846); kirjamees ja köster Caspar Franz Lorenzsonn (1811-1880); köster Heinrich Gottlieb Lorenzsonn (1803-1847); trükkal ja kirjastaja Friedrich Wilhelm Bonn (1812-1881); linnapead Oskar Alexander Brackmann (1841-1927) ja Jaan Leesment (1870-1941)

  18. NATURE IN THE ROMANTIC PERSPECTIVE: LOOK TRANSFORMATIONS

    Directory of Open Access Journals (Sweden)

    Ana Paula de Toledo Soares

    2015-08-01

    Full Text Available This paper aims to elaborate a reflection that follows the displacement of the human view of nature, in the 19th century to the 20th century. Our focus of observation is Gerd Bornheim’s reflections, as well as Deleuze and Schelling’s texts. We selected as object of analysis one Caspar David Friedrich’s screen and Walt Whitman and Alberto Caeiro’s poems, to elaborate the questions.

  19. Drawing as communicating vessels: An apologia (or not)

    OpenAIRE

    Spiller, Neil

    2016-01-01

    This entry is a transcription of the opening keynote for the two-day international, peer reviewed conference held at the Bartlett School of Architecture, UCL on November 10-11 2016. It was simultaneously published in the book, "Drawing Futures - Speculations in Contemporary Drawing for Art and Architecture", edited by Laura Allen and Luke Caspar Pearson. It outlines my 30 years of speculative architectural drawing.

  20. Persistence of Physics and Engineering Students via Peer Mentoring, Active Learning, and Intentional Advising

    CERN Document Server

    McCavit, Karla

    2016-01-01

    We have developed and implemented a low-cost peer-mentoring program that blends personal and academic support to help students achieve academic success in the introductory courses required for the Physics Major or the Dual-Degree Program in Engineering. As a result of this program, retention has increased among entering science, technology, engineering and mathematics students at Albion College as they move through the introductory classes, as shown by a 20 per cent increase in retention from first-semester to third-semester physics courses compared to years when this program was not in place.

  1. Phyllochron estimation in intercropped strawberry and monocrop systems in a protected environment

    Directory of Open Access Journals (Sweden)

    Heloísa Ferro Constâncio Mendonça

    2012-03-01

    Full Text Available The phyllochron is defined as the time required for the appearance of successive leaves on a plant; this characterises plant growth, development and adaptation to the environment. To check the growth and adaptation in cultivars of strawberry grown intercropped with fig trees, it was estimated the phyllochron in these production systems and in the monocrop. The experiment was conducted in greenhouses at the University of Passo Fundo (28º15'41'' S, 52º24'45'' W and 709 m from June 8th to September 4th, 2009; this comprised the period of transplant until the 2nd flowering. The cultivars Aromas, Camino Real, Albion, Camarosa and Ventana, which seedlings were originated from the Agrícola LLahuen Nursery in Chile, as well as Festival, Camino Real and Earlibrite, originated from the Viansa S.A. Nursery in Argentina, were grown in white polyethylene bags filled with commercial substrate (Tecnomax® and evaluated. The treatments were arranged in a randomised block design and four replicates were performed. A linear regression was realized between the leaf number (LN in the main crown and the accumulated thermal time (ATT. The phyllochron (degree-day leaf-1 was estimated as the inverse of the angular coefficient of the linear regression. The data were submitted to ANOVA, and when significance was observed, the means were compared using the Tukey test (p < 0.05. The mean and standard deviation of phyllochrons of strawberry cultivars intercropped with fig trees varied from 149.35ºC day leaf-1 ± 31.29 in the Albion cultivar to 86.34ºC day leaf-1 ± 34.74 in the Ventana cultivar. Significant differences were observed among cultivars produced in a soilless environment with higher values recorded for Albion (199.96ºC day leaf-1 ± 29.7, which required more degree-days to produce a leaf, while cv. Ventana (85.76ºC day leaf-1 ± 11.51 exhibited a lower phyllochron mean value. Based on these results, Albion requires more degree-days to issue a leaf as

  2. Production of strawberry cultivars in closed hydroponic systems and coconut fibre substrate

    Directory of Open Access Journals (Sweden)

    Fabio Rodrigues de Miranda

    Full Text Available The objective of this work was to evaluate yield and average fruit weight of strawberry cultivars Albion, Camarosa, Festival and Oso Grande, in two closed hydroponic systems (gutters and grow bags, using coconut fibre as substrate. The experimental design was of randomised blocks, divided into strips, with five replications. The hydroponic systems did not differ significantly as to yield, with advantages, such as savings in water and fertilizer and reduced environmental impact, over open systems. The most productive cultivar was Festival, followed by Oso Grande, with average yields of 6.99 kg m-2 and 5.56 kg m-2 respectively. The cultivars with the greatest fruit weight were Oso Grande and Albion, having averages of 11.8 and 11.1 g respectively, with the former being significantly superior to the latter. The highest yield (7.4 kg m-2 was obtained from the cultivar Festival under the gutter system. The Ibiapaba region has conditions which are favourable to strawberry production in relation to precocity (harvesting starts in the 6th week of growth and production continues throughout the year; however there is a need to test new cultivars and to improve the cultivation techniques with an aim to producing larger-sized fruit.

  3. Classification criteria for psoriatic arthritis and ankylosing spondylitis/axial spondyloarthritis.

    Science.gov (United States)

    Rudwaleit, Martin; Taylor, William J

    2010-10-01

    The concept of spondyloarthritides (or spondyloarthropathies, SpAs) that comprises a group of interrelated disorders has been recognised since the early 1970s. While the European Spondyloarthropathy Study Group (ESSG) criteria and the Amor criteria have been developed to embrace the entire group of SpAs, new criteria for psoriatic arthritis have been developed recently. The Classification of Psoriatic Arthritis (CASPAR) study, a large one of more than 1000 patients, led to a new set of validated classification criteria for psoriatic arthritis. Since their publication in 2006 the CASPAR criteria are widely used in clinical studies. In ankylosing spondylitis, the 1984 modified New York criteria have been used widely in clinical studies and daily practice but are not applicable in early disease when the characteristic radiographical signs of sacroiliitis are not visible but active sacroiliitis is readily detectable by magnetic resonance imaging (MRI). This led to the concept of axial SpA that includes patients with and without radiographical damage; candidate criteria for axial SpA were developed based on proposals for a structured diagnostic approach. These criteria were validated in the Assessment of Spondyloarthritis International Society (ASAS) study on new classification criteria for axial SpA, a large international prospective study. In this new criteria, sacroiliitis showing up on MRI has been given as much weight as sacroiliitis on radiographs, thereby also identifying patients with early axial SpA. Both the CASPAR and the ASAS criteria for axial SpA are likely to be of use as diagnostic criteria.

  4. Decision management - projects subject to uncertainty

    Directory of Open Access Journals (Sweden)

    A.E. Paterson

    2003-12-01

    Full Text Available The human mind is normally unable to grasp more than five to nine aspects relating to the same decision circumstances simultaneously. It has been demonstrated that only between four and eight variables significantly affect return on engineering projects (at the 90% level irrespective of scale. The most powerful means of isolating these significant variables is by computer simulation. This is demonstrated through the application of the interactive CASPAR programme to a simulated mining project. The significant variables are separated into controllable, influence able and uncontrollable categories for decision and control purposes since the nature of the speculative risk differs. The managerial treatment of each category is discussed.

  5. BMC Ecology image competition 2014: the winning images

    Science.gov (United States)

    2014-01-01

    BMC Ecology showcases the winning entries from its second Ecology Image Competition. More than 300 individual images were submitted from an international array of research scientists, depicting life on every continent on earth. The journal’s Editorial Board and guest judge Caspar Henderson outline why their winning selections demonstrated high levels of technical skill and aesthetic sense in depicting the science of ecology, and we also highlight a small selection of highly commended images that we simply couldn’t let you miss out on. PMID:25178017

  6. Kunst-Gedanken in Tiecks «Franz Sternbalds Wanderungen»

    Directory of Open Access Journals (Sweden)

    Wolfang Nehring

    2011-10-01

    Full Text Available Ludwig Tieck is not only the most productive and stimulating power of German Roman­ticism with respect to literature but also, largely unnoticed by his contemporaries and critics, an innovative proponent of a new art. His Sternbald goes way beyond the position of Wackenroder’s Herzensergießungen from which it started. It not only influenced the artwork of the two most important romantic painters, Philipp Otto Runge and Caspar David Fried­rich, but advocates, in a way, twentieth-century ideas of modern painting.

  7. [From Vesalius to Descartes: the heart, the life].

    Science.gov (United States)

    Bitbol-Hespériès, Annie

    2014-01-01

    At the end of 1629, Descartes, settled in the Lower Countries, began studying anatomy and performing dissections in order to write L'Homme (The Treatise on Man). He acknowledged his debt towards "Vezalius and the others". In those years, in Europe, the influence of Vesalius was increasing, as shown by Rembrandt's Anatomy of Dr Tulp and by the Theatrum anatomicum by Caspar Bauhin. Descartes rejected the divisions of the soul, then a common place in medical treatises, and he stated a principle of life defined by the heath in the heart linked to the new demonstration of the circulation of the blood by William Harvey.

  8. BMC Ecology image competition 2014: the winning images.

    Science.gov (United States)

    Harold, Simon; Henderson, Caspar; Baguette, Michel; Bonsall, Michael B; Hughes, David; Settele, Josef

    2014-08-29

    BMC Ecology showcases the winning entries from its second Ecology Image Competition. More than 300 individual images were submitted from an international array of research scientists, depicting life on every continent on earth. The journal's Editorial Board and guest judge Caspar Henderson outline why their winning selections demonstrated high levels of technical skill and aesthetic sense in depicting the science of ecology, and we also highlight a small selection of highly commended images that we simply couldn't let you miss out on.

  9. A Cross-Cultural Comparison of Three Risk Tolerance Measures: Turkey and the United States Case

    Directory of Open Access Journals (Sweden)

    Jorge Ruiz-Manjivar

    2016-01-01

    Full Text Available An individual’s attitude toward financial risk tolerance (FRT is an important preference that influences financial decision-making under uncertainty. FRT involves inter-temporal resource allocation. Accurate and reliable measures of FRT are essential for professionals advising consumers as well as researchers who are trying to predict, and understand consumer behavior. This study explores cross-cultural risk tolerance by comparing random samples from Turkey, and the United States. Similar and distinctive attitudes and patterns regarding FRT are identified. Three subjective measures of FRT are employed in this study: Grable and Lytton (1999, Hanna, Gutter and Fan’s (2001 improved version of Barsky, Juster, Kimball and Shapiro (1997, and the Survey of Consumer Finance’s item on risk tolerance. Data was collected via an online survey that used the above-mentioned FRT measures. There were two versions: the original American English version, and a culturally translated Turkish version. To explore the correlation of FRT among measures, we use bivariate analysis by individually employing Pearson Chi-square test of independence, and cross tabulations analysis to each sample. In addition, by pooling both samples, we conduct cumulative logistic regression. We delineate FRT differences and consistencies between countries across subjective financial risk tolerance measures.

  10. A Cross-Cultural Comparison of Three Risk Tolerance Measures: Turkey and The United States Case

    Directory of Open Access Journals (Sweden)

    Jorge Ruiz-Menjivar

    2014-01-01

    Full Text Available An individual’s attitude toward financial risk tolerance (FRT is an important preference that influences financial decision-making under uncertainty. FRT involves inter-temporal resource allocation. Accurate and reliable measures of FRT are essential for professionals advising consumers as well as researchers who are trying to predict, and understand consumer behavior. This study explores cross-cultural risk tolerance by comparing random samples from Turkey, and the United States. Similar and distinctive attitudes, and patterns regarding FRT are identified.  Three subjective measures of FRT are employed in this study: Grable and Lytton (1999, Hanna, Gutter and Fan’s (2001 improved version of Barsky, Juster, Kimball and Shapiro (1997, and the Survey of Consumer Finance’s item on risk tolerance. Data was collected via an online survey that used the above-mentioned FRT measures. There were two versions: the original American English version, and a culturally translated Turkish version. To explore the correlation of FRT among measures, we use bivariate analysis by individually employing Pearson Chi-square test of independence, and cross tabulations analysis to each sample. In addition, by pooling both samples, we conduct cumulative logistic regression. We delineate FRT differences and consistencies between countries across subjective financial risk tolerance measures.

  11. Risk and gender: measuring risk tolerance and gender differences

    Directory of Open Access Journals (Sweden)

    Alexandre Majola Gava

    2008-01-01

    Full Text Available In recent years there has been a growing interest among researchers and fund managers in understanding investor’s behavior towards risk. The lack of a standard model leads financial professionals to develop and use simplified methods, usually limited to simple conversations with clients about their level of well being in a variety of scenarios (GRABLE; LYTTON, 2001. The present article has two main objectives. The first objective is to develop and to verify the validity of a research instrument for the classification of investors according to their risk tolerance. The second objective is to verify if gender has an influence on risk tolerance. A total of 544 questionnaires were applied to undergraduate and post-graduate students of seven Brazilian universities. A Factor Analysis established that there are three different risk factors in this research. When compared to the SCF question, the correlation analysis showed that the research questionnaire is able to determine other factors. The segmentation of the sample according to gender showed that women are more risk-averse than men, as documented by other studies. documented by other studies.

  12. Aliens and time in the machine age

    Science.gov (United States)

    Brake, Mark; Hook, Neil

    2006-12-01

    The 19th century saw sweeping changes for the development of astrobiology, both in the constituency of empirical science encroaching upon all aspects of life and in the evolution of ideas, with Lyell's Principles of Geology radically raising expectation of the true age of the Earth and the drama of Darwinism questioning biblically literalist accounts of natural history. This paper considers the popular culture spun on the crackling loom of the emergent aspects of astrobiology of the day: Edward Bulwer-Lytton's The Coming Race (1871), which foretold the race of the future, and satirist Samuel Butler's anticipation of machine intelligence, `Darwin Among the Machines', in his Erewhon (1872). Finally, we look at the way Darwin, Huxley and natural selection travelled into space with French astronomer Camille Flammarion's immensely popular Récits de l'infini (Stories of Infinity, 1872), and the social Darwinism of H.G. Wells' The Time Machine (1895) and The War of the Worlds (1898). These works of popular culture presented an effective and inspiring communication of science; their crucial discourse was the reducible gap between the new worlds uncovered by science and exploration and the fantastic strange worlds of the imagination. As such they exemplify a way in which the culture and science of popular astrobiology can be fused.

  13. Gloriana de Britten et le rêve de l’opéra anglais Britten’s Gloriana and the dream of english opera

    Directory of Open Access Journals (Sweden)

    Gilles Couderc

    2009-10-01

    Full Text Available The composition of Benjamin Britten’s sixth opera, Gloriana, originates from a conversation about emblematic national operas, the lack thereof in the British repertory and the need for Britten to compose such an opera to coincide with the Coronation of the young Queen Elizabeth II in 1953. Britten’s insistence on composing such an opera based on the tragic love story between the first Queen Elizabeth and Essex, depicted in Lytton Strachey’s dramatic biography, raises several questions. Why should Britten, the controversial composer of several controversial works, curry royal patronage? Why should he insist on composing for an event of such national significance? Why should Britten ride the hobby horse of a national opera and share the obsession of a national opera common to German composers of the Romantic generation? Gloriana turns out to be one of the elements that point to modernist and cosmopolitan Britten’s great sense of a national identity as a composer and his claim to work within a distinctly English tradition. The Coronation opera is also one of many endeavours in Britten’s production to resuscitate English Opera, his life-long ambition. With Gloriana, Britten once more leads the fight to eradicate English people’s prejudices against musicians in general and their own composers in particular and to give the lie to the dictum that Britain is the country that has no music.

  14. 斯特拉奇与“新传记”——历史与文化的透视

    Institute of Scientific and Technical Information of China (English)

    唐岫敏

    2006-01-01

    本论文是对发生在英国两次世界大战期间的"新传记"的研究.1918年,第一次世界大战结束的当年,英国现代主义作家雷顿·斯特拉奇(Lytton Strachey,1880-1932)发表了《维多利亚时代名人传》,其发人深省的讽刺文体、栩栩如生的描写、别具一格的选材和侦探式的心理分析立即引起人们的注意,在接下来的20年间效仿者无数,形成一股潮流.1927年伍尔芙(Virginia Woolf)在一篇书评中使用"新传记"来定位这种与维多利亚时代旧传记绝对不同的现代主义传记.

  15. Crescimento do morangueiro: influência da cultivar e da posição da planta no canteiro Strawberry growth: effect of cultivar and plant position in the bed

    Directory of Open Access Journals (Sweden)

    André Samuel Strassburger

    2011-02-01

    Full Text Available O objetivo deste trabalho foi avaliar o crescimento de cultivares de morangueiro em sistema de cultivo orgânico, observando a influência da posição da planta no canteiro sobre a produção acumulada e a partição de massa seca entre os órgãos aéreos das plantas. O experimento foi realizado na Embrapa Clima Temperado, Estação Experimental Cascata, Pelotas, RS. Os tratamentos constaram da combinação de dois fatores experimentais: cultivar ('Albion', 'Aromas', 'Camarosa' e 'Camino Real' e a posição das plantas no canteiro (Central e Bordadura. O delineamento experimental adotado foi o de blocos completos casualizados com parcelas divididas e quatro repetições. A cultivar 'Camarosa' apresentou maior produção de massa seca dos órgãos aéreos das plantas (62,3; 27,5 e 88,0g planta-1 para folha, coroa e frutos, respectivamente e, juntamente com a 'Aromas', maior produtividade (64,2 e 59,1Mg ha-1, respectivamente. A cultivar 'Aromas' apresentou a maior contribuição proporcional dos frutos para a composição do total de massa seca da planta (60,6% e o maior índice de colheita (88%. A posição das plantas não influenciou o crescimento e a produtividade, indicando ausência de efeito de bordadura para as cultivares 'Albion', 'Aromas', 'Camarosa' e 'Camino Real'.The aim of this research was to evaluate the growth of strawberry cultivars growing in organic crop system observing the influence of plant position in the bed on accumulated dry matter production and its partitioning among the aboveground plant organs. The experiment was conducted in Embrapa Clima Temperado, Estação Experimental Cascata, Pelotas, RS. The treatments were compose by the combination of two experimental factors: cultivar ('Aromas', 'Albion', 'Camarosa' and 'Camino Real' and plant position in the bed (Central and Border. The experimental design used was randomized blocks with split-plots and four replications. 'Camarosa' cultivar presented highest dry mass

  16. Avaliação de extrato de algas no progresso temporal da mancha de Mycosphaerella em cultivares de morangueiro Evaluation of seaweed extract on temporal progress of Mycosphaerella leaf spot in strawberry cultivars

    Directory of Open Access Journals (Sweden)

    Cristiano Nunes Nesi

    2013-02-01

    Full Text Available Em morangueiros, a mancha das folhas, causada por Mycosphaerella fragariae, é uma das doenças mais comuns na cultura, o que torna importantes os estudos de controle alternativo e de cultivares, sobre o progresso da epidemia. Em busca de práticas alternativas para seu controle, avaliou-se o efeito de cultivares de morangueiro e do extrato da alga Ascophyllum nodosum, na expressão dos sintomas de mycosphaerella, além de avaliar o ajuste de modelos de crescimento para o progresso temporal da incidência e severidade da doença. Utilizou-se o extrato de algas a 29%, na dose de 2 L ha-1, aplicado no solo, na folha e em ambos. As cultivares Dover, Toyonoka, Albion, Camarosa, Ventana, Campinas, Tudla e Camino Real foram avaliadas, quinzenalmente, quanto a incidência e severidade da doença. Utilizou-se o delineamento inteiramente casualizado, com parcelas subdivididas e três repetições. Com os dados de incidência e severidade, calculou-se a área abaixo da curva de progresso da doença e utilizou-se a análise de variância para avaliar o efeito de cultivares e do extrato de algas. Aos dados do progresso temporal da incidência e da severidade, em cada cultivar, foram ajustados os modelos monomolecular, logístico e de Gompertz. O extrato de algas não apresentou efeito ou interação com cultivares, no controle da mycosphaerella. Houve efeito de cultivar com menor intensidade da doença, em Albion e Ventana, devido, principalmente, ao atraso na epidemia, pela redução do inóculo inicial efetivo. Aos dados de progresso temporal da incidência e da severidade ajustaram-se, respectivamente, os modelos logístico e monomolecular, para todas as cultivares.Leaf spot, caused by Mycosphaerella fragariae, is a common foliar disease infectious to a broad variety of strawberry cultivars. In a search for alternative control methods, seaweed extract from Ascophyllum nodosum was applied to strawberry cultivars and evaluated for its effect on

  17. The Meteoritical Bulletin, No. 81, 1997 July

    Science.gov (United States)

    Grossman, J.N.

    1997-01-01

    Meteoritical Bulletin, No. 81 lists 181 new meteorites. Noteworthy among these are a new lunar meteorite (Dar al Gani 262), four observed falls (Dong Ujimqin Qi, Galkiv, Mount Tazerzait, and Piplia Kalan), four irons (Albion, Great Sand Sea 003, Hot Springs, and Mont Dieu), two mesosiderites (Dong Ujimqin Qi and Lamont), an acapulcoite (FRO 95029), a eucrite (Piplia Kalan), two probably-paired ureilites (Dar al Gani 164 and 165), an R chondrite (Hammadah al Hamra 119), an ungrouped type-3 chondrite (Hammadah al Hamra 180), a highly unequilibrated ordinary chondrite (Wells, LL3.3), and a variety of carbonaceous and unequilibrated ordinary chondrites from Libya and Antarctica. All italicized abbreviations refer to addresses listed in the appendix. ?? Meteoritical Society, 1997.

  18. THE IMPACT OF ENVIRONMENTALLY FRIENDLY POSTHARVEST TREATMENTS ON THE ANTIOXIDANT ACTIVITY OF STRAWBERRY FRUITS DURING STORAGE

    Directory of Open Access Journals (Sweden)

    Ivna Štolfa

    2014-12-01

    Full Text Available Proper postharvest storage is an effective way to maintain the quality and nutritional values of fruits. The aim of this study was to determine how environmentally friendly postharvest treatments with salicylic acid solution, colloidal silver solution and ozone, affect the antioxidant activity of strawberry fruits (Fragaria x ananassa Duch. cv. Albion during 7 days of storage at 4°C. The content of ascorbic acid, total phenols and antioxidant activity of strawberry fruits were determined spec-trophotometrically. After 7 days of storage in strawberry fruits treated with all three treatments separately, the contents of ascorbic acid were higher than in the control fruits, supporting the usefulness of these treatments for preserving fruit quality and nutritional value during storage. The treatment with salicylic acid solution showed the most beneficial effect during storage causing a significant increase in the content of ascorbic acid, phenols and antioxidant activity at the end of the storage period.

  19. H-2g, a glucose analog of blood group H antigen, mediates monocyte recruitment in vitro and in vivo via IL-8/CXCL8

    Directory of Open Access Journals (Sweden)

    Rabquer BJ

    2012-09-01

    Full Text Available Bradley J Rabquer,1,2 Yong Hou,1 Jeffrey H Ruth,1 Wei Luo,1 Daniel T Eitzman,1 Alisa E Koch,3,1 Mohammad A Amin11University of Michigan Medical School, Department of Internal Medicine, Ann Arbor, MI, USA; 2Albion College, Biology Department, Albion, MI, USA; 3VA Medical Service, Department of Veterans Affairs, Ann Arbor, MI, USAObjective: Monocyte (MN recruitment is an essential inflammatory component of many autoimmune diseases, including rheumatoid arthritis (RA. In this study we investigated the ability of 2-fucosyllactose (H-2g, a glucose analog of blood group H antigen to induce MN migration in vivo and determined if H-2g-induced interleukin-8 (IL-8/CXCL8 plays a role in MN ingress in RA.Methods: Sponge granuloma and intravital microscopy assays were performed to examine H-2g-induced in vivo MN migration and rolling, respectively. MNs were stimulated with H-2g, and the production of IL-8/CXCL8 was assessed by enzyme-linked immunosorbent assay and quantitative polymerase chain reaction. Lastly, in vitro MN migration assays and an in vivo RA synovial tissue severe combined immunodeficiency mouse model were used to determine the role of IL-8/CXCL8 in H-2g-induced MN migration.Results: In vivo, H-2g induced significantly greater MN migration compared to phosphate buffered saline. Intravital microscopy revealed that H-2g mediates MN migration in vivo by inducing MN rolling. In addition, H-2g induced MN production of IL-8/CXCL8, a process that was dependent on Src kinase. Moreover, we found that H-2g mediated MN migration in vitro, and in vivo migration was inhibited by a neutralizing anti-IL-8/CXCL8 antibody.Conclusion: These findings suggest that H-2g mediates MN recruitment in vitro and in vivo (in part via IL-8/CXCL8.Keywords: inflammation, rheumatoid arthritis, chemokine, migration

  20. The occurrence of psoriatic arthritis in Denmark

    DEFF Research Database (Denmark)

    Pedersen, Ole Birger Vesterager; Svendsen, Anders Jørgen; Ejstrup, Leif;

    2008-01-01

    OBJECTIVE: To apply and compare different classification criteria on a representative nationwide sample of psoriatic arthritis (PsA) twins and to estimate the prevalence and incidence of PsA. METHODS: The study comprised three Danish nationwide twin cohorts. In 1994 37,388 Danish twin individuals...... of 228 twin individuals reported PsA and 184 (81%) participated in clinical validation. By using the M&W and CASPAR criteria 54 and 50 cases were diagnosed with PsA respectively. The positive predictive value of self-reported PsA was 31%. According to the M&W and CASPAR criteria the prevalence was 0.......15% (95% CI: 0.13%, 0.22%) and 0.14% (95% CI: 0.11%, 0.19%) respectively. The annual incidence rate based on new self-reported cases in 2002 was 6/100,000 pyr (95% CI: 3/100,000 pyr, 11/100,000 pyr). CONCLUSION: The positive predictive value of self-reported PsA was 31%. The prevalence and incidence...

  1. Combination of the auxins NAA, IBA, and IAA with GA3 improves the commercial seed-tuber production of potato (Solanum tuberosum L.) under in vitro conditions.

    Science.gov (United States)

    Kumlay, Ahmet Metin

    2014-01-01

    The study compared the effects of 1.0 × MS medium containing various concentrations of α-naphthaleneacetic acid (NAA), indole-3-acetic acid (IAA), and indole-3-butyric acid (IBA), alone or in combination with gibberellic acid (GA3) in micropropagation of three potato (Solanum tuberosum L.) cultivars Pasinler, Granola, and Caspar using binodal stem cuttings. The results testified improved regeneration on 1.0 × MS medium containing variants of NAA, IAA, and IBA plus GA3 on all cultivars. The minimum days to shoot induction on three cultivars ranged 4.25-5 d on 1.0 × MS medium containing 0.25 mg L(-1) GA3 + 1 mg L(-1) NAA. The longest shoots (11.8 cm), maximum number of nodes (13.50), and maximum number of leaves (11.00) were recorded on cv. Caspar on 1.0 × MS medium containing 1 mg L(-1) NAA + 0.25 mg L(-1) GA3. The minimum time to root induction (12.25 d) was noted on cv. Pasinler on the same medium. All of the regenerated shoots could be easily rooted. The results showed that the combined effect of various concentrations of NAA, IAA, and IBA plus GA3 was more pronounced compared to the auxins used alone. The results of this research are of significant importance for potato breeders.

  2. New Insights into Viral Architecture via Affine Extended Symmetry Groups

    Directory of Open Access Journals (Sweden)

    T. Keef

    2008-01-01

    Full Text Available Since the seminal work of Caspar and Klug on the structure of the protein containers that encapsulate and hence protect the viral genome, it has been recognized that icosahedral symmetry is crucial for the structural organization of viruses. In particular, icosahedral symmetry has been invoked in order to predict the surface structures of viral capsids in terms of tessellations or tilings that schematically encode the locations of the protein subunits in the capsids. Whilst this approach is capable of predicting the relative locations of the proteins in the capsids, a prediction on the relative sizes of different virus particles in a family cannot be made. Moreover, information on the full 3D structure of viral particles, including the tertiary structures of the capsid proteins and the organization of the viral genome within the capsid are inaccessible with their approach. We develop here a mathematical framework based on affine extensions of the icosahedral group that allows us to address these issues. In particular, we show that the relative radii of viruses in the family of Polyomaviridae and the material boundaries in simple RNA viruses can be determined with our approach. The results complement Caspar and Klug's theory of quasi-equivalence and provide details on virus structure that have not been accessible with previous methods, implying that icosahedral symmetry is more important for virus architecture than previously appreciated.

  3. "A Myth Becomes Reality": Kaspar Hauser as Messianic Wild Child

    Directory of Open Access Journals (Sweden)

    Ulrich Struve

    1998-06-01

    Full Text Available The topos of the "Wild Child" occupies an important place in the mythic and literary imagination of the West. The European climax of a long line of wild children, Kaspar Hauser was a nineteenth-century German foundling whose fate has inspired a host of novels, dramas, novellas, poems, songs, and movies, even an opera and a ballet. It has been treated by Paul Verlaine, R. M. Rilke, and Klaus Mann, by the Dada poet Hans Arp, by the dramatist Peter Handke, and by the filmmaker Werner Herzog. This article offers a brief historical sketch of Hauser's life before discussing a key aspect of the literary Kaspar Hauser reception: the motif of the foundling as a latter-day messiah. By examining a set of twentieth-century texts that develop this motif in an exemplary manner—Jakob Wassermann's novel Caspar Hauser or The Inertia of the Heart , Georg Trakl's Kaspar Hauser Song , the anthroposophist Kaspar Hauser poems by Emma Krell-Werth, and David Constantine's Caspar Hauser: A Poem in Nine Cantos —we can gain insight into our century's desire for redemption and its ethical ramifications.

  4. Fas-associated factor 1 plays a negative regulatory role in the antibacterial immunity of Locusta migratoria.

    Science.gov (United States)

    He, Z; Wang, P; Shi, H; Si, F; Hao, Y; Chen, B

    2013-08-01

    Insect immune responses are precisely regulated to maintain immune balance. In this study, the Fas-associated factor 1 (FAF1) gene of Locusta migratoria manilensis, a homologue of the caspar gene that functions as a specific negative regulator in the antibacterial immunity pathway, was cloned. Gene expression analysis showed that FAF1 was expressed throughout the developmental stages and in all tested tissues, but its transcription levels varied significantly. Thus, FAF1 appears to be tightly regulated and is probably involved in multiple physiological processes. In addition, the antimicrobial peptide gene prolixicin was cloned and characterized. After bacterial challenge, prolixicin was rapidly up-regulated, whereas FAF1 was markedly down-regulated. This result was consistent with the observation that prolixicin was hyperactivated when FAF1 was suppressed by RNA interference. Moreover, after bacterial infection, the survival rate of FAF1-knockdown locusts was much higher than that of the wild-type. Taken together, these findings strongly suggest that FAF1 shares a similar function as caspar in Drosophila and may be involved in the negative regulation of antibacterial immunity in locusts.

  5. De volledigheidswaan van biografen

    Directory of Open Access Journals (Sweden)

    H. de Liagre Böhl

    2000-01-01

    Full Text Available A. Kuiper, Een wijze ging voorbij. Het leven van Abel J. Herzberg; L. van Driel, J. Noordegraaf, De Vries en Te Winkel. Een duografie; W. Hazeu, M.C. Escher. Een biografie; J.W. Renders, Zo meen ik dat ook jij bent. Biografie van Jan Hanlo; M. Derks, S. Verheesen-Stegeman, Wetenschap als roeping. Prof. dr. Christine Mohrmann (1903-1988, classica; F. Zwart, Willem Mengelberg (1871-1951. Een biografie 1871-1920The delusion that the scope of a biography is ever fully completeThis review article observes that, since the 1980s, the art of writing biographies has become fully accepted once more in academic circles in the Netherlands. This revival has been stimulated by positive collaborative efforts between historians and Dutch specialists. This harmony is based on their commitment to the principles of the Modem Biography, a style which counts since the first World War as the ‘ideal type’ of the whole genre. This style — which is mostly identified with Lytton Strachey’s Eminent Victorians (1918 - mediates between literature and historical studies. Their followers want to combine: 1. literary eloquence, 2. scholarly accuracy, 3. an analytic and a explicative concept about the personage and his or her work, 4. the skill of placing the character in the context of his or her time. Those four desiderata are used in this article as a point of departure for assessing six Dutch biographies that appeared in 1998. Some of them are excellent, however, all of them show a propensity towards empiricism and prolixity. Unfortunately this trait is characteristic of many recent biographies in The Netherlands

  6. De volledigheidswaan van biografen

    Directory of Open Access Journals (Sweden)

    H. de Liagre Böhl

    2000-01-01

    Full Text Available A. Kuiper, Een wijze ging voorbij. Het leven van Abel J. Herzberg; L. van Driel, J. Noordegraaf, De Vries en Te Winkel. Een duografie; W. Hazeu, M.C. Escher. Een biografie; J.W. Renders, Zo meen ik dat ook jij bent. Biografie van Jan Hanlo; M. Derks, S. Verheesen-Stegeman, Wetenschap als roeping. Prof. dr. Christine Mohrmann (1903-1988, classica; F. Zwart, Willem Mengelberg (1871-1951. Een biografie 1871-1920The delusion that the scope of a biography is ever fully completeThis review article observes that, since the 1980s, the art of writing biographies has become fully accepted once more in academic circles in the Netherlands. This revival has been stimulated by positive collaborative efforts between historians and Dutch specialists. This harmony is based on their commitment to the principles of the Modem Biography, a style which counts since the first World War as the ‘ideal type’ of the whole genre. This style — which is mostly identified with Lytton Strachey’s Eminent Victorians (1918 - mediates between literature and historical studies. Their followers want to combine: 1. literary eloquence, 2. scholarly accuracy, 3. an analytic and a explicative concept about the personage and his or her work, 4. the skill of placing the character in the context of his or her time. Those four desiderata are used in this article as a point of departure for assessing six Dutch biographies that appeared in 1998. Some of them are excellent, however, all of them show a propensity towards empiricism and prolixity. Unfortunately this trait is characteristic of many recent biographies in The Netherlands

  7. Individual brain structure and modelling predict seizure propagation.

    Science.gov (United States)

    Proix, Timothée; Bartolomei, Fabrice; Guye, Maxime; Jirsa, Viktor K

    2017-03-01

    See Lytton (doi:10.1093/awx018) for a scientific commentary on this article.Neural network oscillations are a fundamental mechanism for cognition, perception and consciousness. Consequently, perturbations of network activity play an important role in the pathophysiology of brain disorders. When structural information from non-invasive brain imaging is merged with mathematical modelling, then generative brain network models constitute personalized in silico platforms for the exploration of causal mechanisms of brain function and clinical hypothesis testing. We here demonstrate with the example of drug-resistant epilepsy that patient-specific virtual brain models derived from diffusion magnetic resonance imaging have sufficient predictive power to improve diagnosis and surgery outcome. In partial epilepsy, seizures originate in a local network, the so-called epileptogenic zone, before recruiting other close or distant brain regions. We create personalized large-scale brain networks for 15 patients and simulate the individual seizure propagation patterns. Model validation is performed against the presurgical stereotactic electroencephalography data and the standard-of-care clinical evaluation. We demonstrate that the individual brain models account for the patient seizure propagation patterns, explain the variability in postsurgical success, but do not reliably augment with the use of patient-specific connectivity. Our results show that connectome-based brain network models have the capacity to explain changes in the organization of brain activity as observed in some brain disorders, thus opening up avenues towards discovery of novel clinical interventions. © The Author (2017). Published by Oxford University Press on behalf of the Guarantors of Brain.

  8. Heavenly Networks. Celestial Maps and Globes in Circulation between Artisans, Mathematicians, and Noblemen in Renaissance Europe.

    Science.gov (United States)

    Gessner, Samuel

    2015-01-01

    The aim of this paper is to examine the iconography on a set of star charts by Albrecht Dürer (1515), and celestial globes by Caspar Vopel (1536) and Christoph Schissler (1575). The iconography on these instruments is conditioned by strong traditions which include not only the imagery on globes and planispheres (star charts), but also ancient literature about the constellations. Where this iconography departs from those traditions, the change had to do with humanism in the sixteenth century. This "humanistic" dimension is interwoven with other concerns that involve both "social" and "technical" motivations. The interplay of these three dimensions illustrates how the iconography on celestial charts and globes expresses some features of the shared knowledge and shared culture between artisans, mathematicians, and nobles in Renaissance Europe.

  9. Anatomy and histology of rodent and human major salivary glands: -overview of the Japan salivary gland society-sponsored workshop-.

    Science.gov (United States)

    Amano, Osamu; Mizobe, Kenichi; Bando, Yasuhiko; Sakiyama, Koji

    2012-10-31

    MAJOR SALIVARY GLANDS OF BOTH HUMANS AND RODENTS CONSIST OF THREE PAIRS OF MACROSCOPIC GLANDS: parotid, submandibular, and sublingual. These glands secrete serous, mucous or mixed saliva via the proper main excretory ducts connecting the glandular bodies with the oral cavity. A series of discoveries about the salivary ducts in the 17th century by Niels Stensen (1638-1686), Thomas Wharton (1614-1673), and Caspar Bartholin (1655-1738) established the concept of exocrine secretion as well as salivary glands. Recent investigations have revealed the endocrine functions of parotin and a variety of cell growth factors produced by salivary glands.The present review aims to describe macroscopic findings on the major salivary glands of rodents and the microscopic differences between those of humans and rodents, which review should be of interest to those researchers studying salivary glands.

  10. Elzevirian Republics, wise merchants, and new perspectives on Spain and Portugal in the seventeenth-century Dutch Republic

    Directory of Open Access Journals (Sweden)

    Sina Rauschenbach

    2013-05-01

    Full Text Available Between 1625 and 1649, the Leiden publishing house Elzevir issued a series of thirty-five descriptions of all European, a selection of non-European, and three ancient states, that became known as the ‘Elzevirian Republics’. This essay focuses on two of these ‘Republics’, Johannes de Laet’s descriptions of Spain and Portugal. I argue that these books convey an attitude towards geopolitics that is best understood in the light of Caspar Barlaeus’s ideal of the ‘wise merchant’ (mercator sapiens and the historical regent-merchant culture in seventeenth-century Amsterdam. The essay draws on recent scholarship in the history of knowledge, commerce, and the pre-history of objectivity.

  11. Epigenesis in Kant: Recent reconsiderations.

    Science.gov (United States)

    Zammito, John H

    2016-08-01

    Epigenesis has become a far more exciting issue in Kant studies recently, especially with the publication of Jennifer Mensch's Kant' Organicism. In my commentary, I propose to clarify my own position on epigenesis relative to that of Mensch and others by once again considering the discourse of epigenesis in the wider eighteenth century. Historically, I maintain that Kant was never fully an epigenesist because he feared its materialist implications. This makes it highly unlikely that he drew heavily, as other interpreters like Dupont and Huneman have suggested, on Caspar Friedrich Wolff for his ultimate theory of "generic preformation." In order to situate more precisely what Kant made of epigenesis, I distinguish his metaphysical use, as elaborated by Mensch, from his view of it as a theory for life science. In that light, I raise questions about the scope and authority of philosophy vis a vis natural science.

  12. TbNb6Sn6: the first ternary compound from the rare earth–niobium–tin system

    Directory of Open Access Journals (Sweden)

    Viktor Hlukhyy

    2010-12-01

    Full Text Available The title compound, terbium hexaniobium hexastannide, TbNb6Sn6, is the first ternary compound from the rare earth–niobium–tin system. It has the HfFe6Ge6 structure type, which can be analysed as an intergrowth of the Zr4Al3 and CaCu5 structures. All the atoms lie on special positions; their coordination geometries and site symmetries are: Tb (dodecahedron 6/mmm; Nb (distorted icosahedron 2mm; Sn (Frank–Caspar polyhedron, CN = 14–15 6mm and overline{6}m2; Sn (distorted icosahedron overline{6}m2. The structure contains a graphite-type Sn network, Kagome nets of Nb atoms, and Tb atoms alternating with Sn2 dumbbells in the channels.

  13. Curating Scientific Research Data for the Long Term: A Preservation Analysis Method in Context

    Directory of Open Access Journals (Sweden)

    Esther Conway

    2011-10-01

    Full Text Available The challenge of digital preservation of scientific data lies in the need to preserve not only the dataset itself but also the ability it has to deliver knowledge to a future user community. A true scientific research asset allows future users to reanalyze the data within new contexts. Thus, in order to carry out meaningful preservation we need to ensure that future users are equipped with the necessary information to re-use the data. This paper presents an overview of a preservation analysis methodology which was developed in response to that need on the CASPAR and Digital Curation Centre SCARP projects. We intend to place it in relation to other digital preservation practices, discussing how they can interact to provide archives caring for scientific data sets with the full arsenal of tools and techniques necessary to rise to this challenge.

  14. The Four Lives of a Nuclear Accelerator

    Science.gov (United States)

    Wiescher, Michael

    2017-06-01

    Electrostatic accelerators have emerged as a major tool in research and industry in the second half of the twentieth century. In particular in low energy nuclear physics they have been essential for addressing a number of critical research questions from nuclear structure to nuclear astrophysics. This article describes this development on the example of a single machine which has been used for nearly sixty years at the forefront of scientific research in nuclear physics. The article summarizes the concept of electrostatic accelerators and outlines how this accelerator developed from a bare support function to an independent research tool that has been utilized in different research environments and institutions and now looks forward to a new life as part of the experiment CASPAR at the 4,850" level of the Sanford Underground Research Facility.

  15. [Carl Gustav Carus, the first director of the newly established maternity institute of the Dresden Royal Surgical-Medical Academy 1814-1827].

    Science.gov (United States)

    Sarembe, B

    1989-01-01

    Carl Gustav Carus was born in 1789 in Leipzig. He studied at the University of Leipzig. His specialization in Gynecology and Obstetrics took place at the Triersches Maternity Hospital. In 1814 he was named Professor for Obstetrics in Dresden at the Royal-Surgical-Medical-Academy. He was the head of the Maternity Hospital till 1827. Under his direction many midwives, students and physicians were educated. He published numerous articles and books on medical and philosophical-psychological topics. He was a talented artist of the Romantic especially in painting landscapes. He was a friend of Caspar David Friedrich and Johann Wolfgang von Goethe. After 1827 he was the physician in ordinary to 3 saxonian kings. He died in 1869. The Medical Academy in Dresden bears his name "Carl Gustav Carus" since its foundation.

  16. Virus Structure: From Crick and Watson to a New Conjecture

    CERN Document Server

    Iorio, Alfredo

    2007-01-01

    We conjecture that certain patterns (scars), theoretically and numerically predicted to be formed by electrons arranged on a sphere to minimize the repulsive Coulomb potential (the Thomson problem) and experimentally found in spherical crystals formed by self-assembled polystyrene beads (an instance of the generalized Thomson problem), could be relevant to extend the classic Caspar and Klug construction for icosahedrally-shaped virus capsids. The main idea is that scars could be produced at an intermediate stage of the assembly of the virus capsids and the release of the bending energy present in scars into stretching energy could allow for a variety of non-spherical capsids' shapes. The conjecture can be tested in experiments on the assembly of artificial protein-cages where these scars should appear.

  17. [Phenomenological anthropological social psychiatry--paving the way for a theoretical reanimation].

    Science.gov (United States)

    Thoma, Samuel

    2012-11-01

    This article tries to link the present lack of theoretical discussion within German Social Psychiatry with a loss of phenomenological and anthropological thought. The so-called Phenomenological Psychiatry used to play a very important role in German psychiatry during the 50 ies until the 70 ies and had strong influences on the first reformers of German psychiatry, such as Walter Ritter von Baeyer, Heinz Häfner, Caspar Kulenkampff, Karl Peter Kisker and Erich Wulff. Their reforms were not only founded by a social criticism put forth by theories such as marxism (Basaglia, Wulff) or structuralism (Foucault) but also by a concrete notion of what it is like to suffer from mental illness and what kind of needs are linked to such suffering. This very notion was given by the phenomenological approach. Finally the article tries to give reasons for today's reciprocal loss of connection of the phenomenological and the socio-psychiatric school.

  18. Utilizing Undergraduate Research Projects to Assist in the Development of Interpretive Resources at City of Rocks National Reserve and Castle Rocks State Park, Idaho

    Science.gov (United States)

    Pogue, K. R.

    2003-12-01

    In the Albion Mountains of southern Idaho, granitic rock of the 28 Ma Almo pluton and 2.5 Ga Green Creek Complex of southern Idaho has weathered and eroded into a spectacular landscape of towers and spires. These unusual landforms impressed travelers on the California Trail who compared their shapes to cathedrals, castles, pyramids, and other man-made structures. The region eventually became know as the City of Rocks and was a local scenic attraction until City of Rocks National Reserve (CRNR) was established in 1989 to provide more effective management for the main group of spires which were drawing an increasing number of tourists. In 2003, Castle Rocks State Park (CRSP) was created to provide both access and protection to a less extensive group of spires located a few kilometers north of the City of Rocks. Interpretive resources at CRNR have generally focused on the human history of the region, particularly its importance to the California Trail, and have largely neglected the fascinating geologic story. Although the general framework of the geology of the Albion Mountains is reasonably well known, this "big-picture" geology does little to answer many of the questions posed by the average visitor. During the summer of 2001, a Keck Geology Consortium undergraduate research project was conducted in CRNR to seek answers to these types of questions. CRNR staff could then utilize the students' research to develop interpretive resources. Six students and two professors spent 4 weeks in the field investigating the structures and processes that have contributed to the architecture of the City of Rocks. The general geomorphology of the Albion Mountains was the focus of a Keck Geology Consortium undergraduate research project conducted during the summer of 2002. Nine students and three professors studied the glacial and landslide history of the highest peaks and the geomorphic evolution of the proposed CRSP. Students working in the Castle Rocks had 2 main goals: 1

  19. Timing and nature of tertiary plutonism and extension in the Grouse Creek Mountains, Utah

    Science.gov (United States)

    Egger, A.E.; Dumitru, T.A.; Miller, E.L.; Savage, C.F.I.; Wooden, J.L.

    2003-01-01

    The Grouse Creek-Albion-Raft River metamorphic core complex in northwestern Utah and southern Idaho is characterized by several Tertiary plutons with a range of ages and crosscutting relations that help constrain the timing of extensional deformation. In the Grouse Creek Mountains, at least three distinct, superimposed, extension-related Tertiary deformational events are bracketed by intrusive rocks, followed by a fourth event: motion on range-bounding faults. The Emigrant Pass plutonic complex was emplaced at depths of less than 10 km into Permianage rocks. SHRIMP U-Pb zircon analysis indicates a three-stage intrusion of the complex at 41.3 ?? 0.3 Ma, 36.1 ?? 0.2 Ma, and 34.3 ?? 0.3 Ma. The two youngest phases represent distinctly younger intrusive event(s) than the oldest phase, separated by more than 5 m.y. The oldest phase cuts several metamorphosed and deformed younger-on-older faults, providing a pre-41 Ma age bracket for oldest extension-related deformation in the region. The youngest phase(s) are interpreted to have been intruded during delelopment of a map-scale. N-S-trending recumbent fold, the Bovine Mountain fold, formed during vertical shortening of roof rocks during intrusion. This second event folded older normal faults that are likely pre-41 Ma. Zircons from the youngest part of the pluton show inheritance from Archean basement (???2.5 Ga) and from its Proterozoic sedimentary cover (???1.65 Ga). The Red Butte pluton, emplaced at 15-20 km depth, intruded highly metamorphosed Archean orthogneiss at 25.3 ?? 0.5 Ma; cores of some zircons yield latest Archean ages of 2.55 Ga. The pluton is interpreted to have been intruded during a third deformational and metamorphic event that resulted in vertical flattening fabrics formed during NW to EW stretching, ultimately leading to thinning of cover and top-to-the west motion on the Ingham Pass fault. The Ingham Pass fault represents an important structure in the Grouse Creek Mountains, as it juxtaposes two parts

  20. Psoriatic Arthritis in Psoriasis Patients: Evaluation of Clinical and Radiological Features

    Directory of Open Access Journals (Sweden)

    Hatice Reşorlu

    2016-08-01

    Full Text Available Objective: The purpose of this study was to perform radiological and clinical determination of the presence of psoriatic arthritis (PsA in patients with psoriasis and to evaluate associations with clinical findings. Materials and Methods: The medical files of 72 patients with psoriasis presenting to our clinic between years 2009-2014 with a pre-diagnosis of PsA were reviewed retrospectively. Hand, foot and sacroiliac joint radiograms were evaluated by a radiologist who was blinded to the patient’s clinical status and who is experienced on musculoskeletal radiology. Patients with psoriasis were divided into two groups according to the presence of arthritis which was determined based on radiographic findings or on Classification Criteria for Psoriatic Arthritis (CASPAR criteria. All patients’ demographic characteristics, length of disease, nail involvement, smoking-alcohol consumption were recorded. Results: The mean age of all patients was 47.24±14.61 years, and the mean duration of disease was 14.13±11.92 years. Smoking and alcohol consumptions were determined in 54.2% (n=39 and 23.6% (n=17 of the cases, respectively. Nail involvement was determined in 56.9% (n=41 of the cases. PsA was determined based on radiological findings in 58.3% (n=42 of the patients. The mean age and age at onset of disease were higher in PsA (+ patients than in radiologically non-PsA subjects. Based on clinical findings, PsA based on CASPAR criteria was determined in only 18.1% (n=13 of all patients. Conclusion: A higher level of PsA was determined using radiological evaluation in this study. The main cause of this condition is the existence of asymptomatic-subclinical patients. A detailed medical history should therefore be taken from patients, and good clinical evaluation is very important. Radiological and clinical evaluation should be performed together in the diagnosis.

  1. SUMO-Enriched Proteome for Drosophila Innate Immune Response

    Science.gov (United States)

    Handu, Mithila; Kaduskar, Bhagyashree; Ravindranathan, Ramya; Soory, Amarendranath; Giri, Ritika; Elango, Vijay Barathi; Gowda, Harsha; Ratnaparkhi, Girish S.

    2015-01-01

    Small ubiquitin-like modifier (SUMO) modification modulates the expression of defense genes in Drosophila, activated by the Toll/nuclear factor-κB and immune-deficient/nuclear factor-κB signaling networks. We have, however, limited understanding of the SUMO-modulated regulation of the immune response and lack information on SUMO targets in the immune system. In this study, we measured the changes to the SUMO proteome in S2 cells in response to a lipopolysaccharide challenge and identified 1619 unique proteins in SUMO-enriched lysates. A confident set of 710 proteins represents the immune-induced SUMO proteome and analysis suggests that specific protein domains, cellular pathways, and protein complexes respond to immune stress. A small subset of the confident set was validated by in-bacto SUMOylation and shown to be bona-fide SUMO targets. These include components of immune signaling pathways such as Caspar, Jra, Kay, cdc42, p38b, 14-3-3ε, as well as cellular proteins with diverse functions, many being components of protein complexes, such as prosß4, Rps10b, SmD3, Tango7, and Aats-arg. Caspar, a human FAF1 ortholog that negatively regulates immune-deficient signaling, is SUMOylated at K551 and responds to treatment with lipopolysaccharide in cultured cells. Our study is one of the first to describe SUMO proteome for the Drosophila immune response. Our data and analysis provide a global framework for the understanding of SUMO modification in the host response to pathogens. PMID:26290570

  2. Avaliação de extrato de algas no progresso temporal da mancha de Mycosphaerella em cultivares de morangueiro

    Directory of Open Access Journals (Sweden)

    Cristiano Nunes Nesi

    2013-02-01

    Full Text Available Em morangueiros, a mancha das folhas, causada por Mycosphaerella fragariae, é uma das doenças mais comuns na cultura, o que torna importantes os estudos de controle alternativo e de cultivares, sobre o progresso da epidemia. Em busca de práticas alternativas para seu controle, avaliou-se o efeito de cultivares de morangueiro e do extrato da alga Ascophyllum nodosum, na expressão dos sintomas de mycosphaerella, além de avaliar o ajuste de modelos de crescimento para o progresso temporal da incidência e severidade da doença. Utilizou-se o extrato de algas a 29%, na dose de 2 L ha-1, aplicado no solo, na folha e em ambos. As cultivares Dover, Toyonoka, Albion, Camarosa, Ventana, Campinas, Tudla e Camino Real foram avaliadas, quinzenalmente, quanto a incidência e severidade da doença. Utilizou-se o delineamento inteiramente casualizado, com parcelas subdivididas e três repetições. Com os dados de incidência e severidade, calculou-se a área abaixo da curva de progresso da doença e utilizou-se a análise de variância para avaliar o efeito de cultivares e do extrato de algas. Aos dados do progresso temporal da incidência e da severidade, em cada cultivar, foram ajustados os modelos monomolecular, logístico e de Gompertz. O extrato de algas não apresentou efeito ou interação com cultivares, no controle da mycosphaerella. Houve efeito de cultivar com menor intensidade da doença, em Albion e Ventana, devido, principalmente, ao atraso na epidemia, pela redução do inóculo inicial efetivo. Aos dados de progresso temporal da incidência e da severidade ajustaram-se, respectivamente, os modelos logístico e monomolecular, para todas as cultivares.

  3. First report of a complete genome sequence for a begomovirus infecting Jatropha gossypifolia in the Americas.

    Science.gov (United States)

    Simmonds-Gordon, R N; Collins-Fairclough, A M; Stewart, C S; Roye, M E

    2014-10-01

    Jatropha gossypifolia is a weed that is commonly found with yellow mosaic symptoms growing along the roadside and in close proximity to cultivated crops in many farming communities in Jamaica. For the first time, the complete genome sequence of a new begomovirus, designated jatropha mosaic virus-[Jamaica:Spanish Town:2004] (JMV-[JM:ST:04]), was determined from field-infected J. gossypifolia in the western hemisphere. DNA-A nucleotide sequence comparisons showed closest identity (84 %) to two tobacco-infecting viruses from Cuba, tobacco mottle leaf curl virus-[Cuba:Sancti Spiritus:03] (TbMoLCV-[CU:SS:03]) and tobacco leaf curl Cuba virus-[Cuba:Taguasco:2005] (TbLCuCUV-[CU:Tag:05]), and two weed-infecting viruses from Cuba and Jamaica, Rhynchosia rugose golden mosaic virus-[Cuba:Camaguey:171:2009] (RhRGMV- [CU:Cam:171:09]) and Wissadula golden mosaic St. Thomas virus-[Jamaica:Albion:2005] (WGMSTV-[JM:Alb:05]). Phylogenetic analysis revealed that JMV-[JM:ST:04] is most closely related to tobacco and tomato viruses from Cuba and WGMSTV-[JM:Alb:05], a common malvaceous-weed-infecting virus from eastern Jamaica, and that it is distinct from begomoviruses infecting Jatropha species in India and Nigeria.

  4. Chemical and isotopic characteristics of brines from three oil- and gas-producing sandstones in eastern Ohio, with applications to the geochemical tracing of brine sources

    Science.gov (United States)

    Breen, K.J.; Angelo, Clifford G.; Masters, Robert W.; Sedam, Alan C.

    1985-01-01

    Chemical and isotopic characteristics of selected inorganic constituents are reported for brines from the Berea Sandstone of Mississippian age, the Clinton sandstone, Albion Sandstone of Silurian age, and the Rose Run formation of Cambrian and Ordovician age in 24 counties in eastern Ohio. Ionic concentrations of dissolved constituents in brines from these formations generally fall in the following ranges (in millimoles per kilogram of brine): Na, Cl > 1,000; 100 Al, I, HCO3, SiO2 Mg, Na, Cl, K, SO4 and Br, and mean values of density and dissolved solids are significantly different at the 95-percent confidence level in each formation. Only potassium has a unique concentration range in each formation. Selected concentration ratios are identified as potential indicators for geochemical tracing of brines having some history of dilution. The k:Na ratios work best for identifying the source formation of an unidentified brine. Isotopic characteristics of hydrogen and oxygen indicate a meteoric origin for the water matrix of the brines. Sulfur isotopes may have utility for differentiating brines from oxidizing ground water.

  5. Studies on Toxicity,Anti—stress and Hepato—Protective properties of Kombucha Tea

    Institute of Scientific and Technical Information of China (English)

    PAULINE,T.; KAVIMANI,S

    2001-01-01

    Objective :The objective of the study was to evaluate toxicity,anti-stress activity and hepatoprotective properties of Kombucha tea.Method :Kombucha tea was fed orally for 15 days using three different doses i.e.normal dose,five and ten times the dose,Rats were then sacrficed and various biochemical,and histological parameters were estimated.Anti-stress activity was evaluated either by 1)by exposing animals to cold and hypoxia and estimating the levels of malondialdehyde and reduced glutathione in plasma/blood or 2) by subjecting the animals to restraint stress and recording faecal output.Hepato-toxicity was induced by challenging the animals to an acute dose of paracetamol(1gm/kg)orally and determining the plasma levels of SGPT,SGOT and MDA.REsults:The effect of oral administration of different doses of K-tea to albion rats was examined and the results indicate that K-tea has no significant toxicity as revealed by various biochemical and histopathological parameters.K-tea has been found to prevent lipid peroxidation and fall in reduced glutathione level when rats were exposed to cold and hypoxia in simulated chamber.Further,K-tea has also been found to decrease the Wrap-restraint faecal pellet output in rats.K-tea has also been found to decrease paracetamol induced hepatotoxicity significantly.Conclusion:The study shows that K-tea has anti-stress and hepato-protective activities.

  6. Effect of hydro-ethanolic extracts of cinnamon (Cinnamomum zeylanicum Blume and common horsetail (Equisetum arvense L. on incidence and severity of Botrytis cinerea on strawberry

    Directory of Open Access Journals (Sweden)

    Pazmiño-Miranda Pilar

    2017-05-01

    Full Text Available The effect of application of three dosages (5, 10 and 15 mL/L and two frequencies (each 6 and 8 days of ethanoic extracts obtained from cinnamon (Cinnamomum zeylanicum Blume and common horsetail (Equisetum arvense L. on incidence and severity of grey mould (Botrytis cinerea on strawberry crop (Fragaria ananassa cv. Albion was evaluated. Experiment was carried out in a randomized block design with factorial arrangement 2 x 3 x 2 + 1, with three replications. Lower incidence and severity percentage in flower and fruit (10.24 and 24.43%, respectively were observed after application of cinnamon extract at 15 mL/L at 6 days interval. Similarly, lower fruit severity (11.86% was observed with the same treatment. In general, reduction in B. cinerea incidence and severity was lower when common horsetail extract was used, compared to cinnamon extracts. According to our results, using of cinnamon hydro-ethanoic extracts could be considered as sustainable alternative for grey mold management in strawberry crops.

  7. Thyroid-stimulating immunoglobulins as measured in a reporter bioassay are not detected in patients with Hashimoto’s thyroiditis and ophthalmopathy or isolated upper eyelid retraction

    Directory of Open Access Journals (Sweden)

    Wall JR

    2014-10-01

    Full Text Available Jack R Wall,1 Hooshang Lahooti,1 Ilhem El Kochairi,1 Simon D Lytton,2 Bernard Champion1 1Department of Medicine, the University of Sydney, Penrith, NSW, Australia; 2SeraDiaLogistics, Munich, Germany Abstract: Although ophthalmopathy is mainly associated with Graves’ hyperthyroidism, milder eye changes are also found in about 25% of patients with Hashimoto’s thyroiditis (HT. The recent finding of negative thyrotropin receptor (TSHR antibodies, as measured in the ­Thyretain™ thyroid-stimulating immunoglobulin (TSI reporter bioassay, in patients with euthyroid Graves’ disease raises the possibility that TSHR antibodies are not the cause of ophthalmopathy in all situations. Here, we have tested serum from patients with HT with and without ophthalmopathy or isolated upper eyelid retraction (UER for TSHR antibodies, using the TSI reporter bioassay and collagen XIII as a marker of autoimmunity against the orbital fibroblast. Study groups were 23 patients with HT with ophthalmopathy, isolated UER, or both eye features and 17 patients without eye signs. Thyretain™ TSI results were expressed as a percentage of the sample-to-reference ratio, with a positive test being taken as a sample-to-reference ratio of more than 140%. Serum collagen XIII antibodies were measured in standard enzyme-linked immunosorbent assay. TSI tests were positive in 22% of patients with HT with no eye signs but in no patient with eye signs. In contrast, TSI tests were positive in 94% of patients with Graves’ ophthalmopathy. Tests were negative in all normal subjects tested. Collagen XIII antibodies were detected in 83% of patients with ophthalmopathy, UER, or both eye features, but in only 30% of patients with no eye signs. Our findings suggest that TSHR antibodies do not play a major role in the pathogenesis of ophthalmopathy or isolated UER in patients with HT. Moreover, the role of TSHR antibodies in the development of ophthalmopathy in patients with Graves

  8. Diagnosis of spondyloarthritis: should we need new criteria?

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    I. Z. Gaidukova

    2015-01-01

    Full Text Available A large number of classification criteria for spondyloarthritis (SpA are simultaneously used in modern rheumatology in the almost complete absence of diagnostic criteria. This poses a number of problems, among which there are two most important ones: 1 the frequent use of classification criteria to make a diagnosis in real clinical practice; 2 the possibility of stating different nosological entities of SpA in one patient in the presence of the same clinical picture.Objective: to investigate the specific features of the diagnosis of SpA and the use of its classification criteria in clinical practice.Subjects and methods. The investigation enrolled 119 patients with the established diagnosis of ankylosing spondylitis (AS, psoriatic arthritis (PsA, undifferentiated axial or peripheral SpA. Whether their clinical picture complied with the modified New York criteria, the European Spondyloarthropathy Study Group (ESSG criteria, the Amor criteria, and the Assessment of Spondyloarthritis International Society (ASAS classification criteria for axial and peripheral SpA and whether the Russian version of the modified New York criteria complied with the Classification criteria of Psoriatic ARthritis (CASPAR were determined in the patients.Results. Sixty-three patients diagnosed with AS (M45, 44 with PsA (M07.0-07.3, 8 with undifferentiated SpA (M46.9, and 4 with nonradiographic axial SpA (M46.8 were followed up by attending physicians. The latter diagnosed AS in 10 patients who met the ASAS criteria for axial PsA but not the modified New York criteria. Twenty-one patients diagnosed as having PsA simultaneously met both the CASPAR criteria and the modified New York criteria, which could establish the diagnosis of AS in these cases. Eighty-one (68.0% out of the 119 patients met the Amor criteria; 98 (82.3% patients, the ESSG criteria; 91 (76.5%, the ASAS criteria for axial SpA; 18 (15.1%, the ASAS criteria for peripheral SpA; 76 (63.8%, the modified New York

  9. Transcriptome analysis of Aedes aegypti transgenic mosquitoes with altered immunity.

    Directory of Open Access Journals (Sweden)

    Zhen Zou

    2011-11-01

    Full Text Available The mosquito immune system is involved in pathogen-elicited defense responses. The NF-κB factors REL1 and REL2 are downstream transcription activators of Toll and IMD immune pathways, respectively. We have used genome-wide microarray analyses to characterize fat-body-specific gene transcript repertoires activated by either REL1 or REL2 in two transgenic strains of the mosquito Aedes aegypti. Vitellogenin gene promoter was used in each transgenic strain to ectopically express either REL1 (REL1+ or REL2 (REL2+ in a sex, tissue, and stage specific manner. There was a significant change in the transcript abundance of 297 (79 up- and 218 down-regulated and 299 (123 up- and 176 down-regulated genes in fat bodies of REL1+ and REL2+, respectively. Over half of the induced genes had predicted functions in immunity, and a large group of these was co-regulated by REL1 and REL2. By generating a hybrid transgenic strain, which ectopically expresses both REL1 and REL2, we have shown a synergistic action of these NF-κB factors in activating immune genes. The REL1+ immune transcriptome showed a significant overlap with that of cactus (RNAi-depleted mosquitoes (50%. In contrast, the REL2+ -regulated transcriptome differed from the relatively small group of gene transcripts regulated by RNAi depletion of a putative inhibitor of the IMD pathway, caspar (35 up- and 140 down-regulated, suggesting that caspar contributes to regulation of a subset of IMD-pathway controlled genes. Infections of the wild type Ae. aegypti with Plasmodium gallinaceum elicited the transcription of a distinct subset of immune genes (76 up- and 25 down-regulated relative to that observed in REL1+ and REL2+ mosquitoes. Considerable overlap was observed between the fat body transcriptome of Plasmodium-infected mosquitoes and that of mosquitoes with transiently depleted PIAS, an inhibitor of the JAK-STAT pathway. PIAS gene silencing reduced Plasmodium proliferation in Ae. aegypti, indicating

  10. Gypsum as a source of sulfur for strawberry cropsGesso agricola como fonte de enxofre para a cultura do morango

    Directory of Open Access Journals (Sweden)

    Universidade Estadual do Centro-Oeste

    2013-09-01

    Full Text Available De uma maneira geral, diversos são os estudos sobre a resposta das plantas ao enxofre (S, porém poucos são específicos para a cultura do morangueiro. A exigência por nutrientes e o estado nutricional é um atributo particular de cada espécie e deve ser levada em conta na determinação da demanda nutricional. O objetivo deste trabalho foi avaliar a influência da aplicação de doses S e fósforo (P no desenvolvimento e produtividade do morangueiro. Foi conduzido um experimento em casa de vegetação, em vasos de 2 Kg de solo (Latossolo Bruno, em Guarapuava-PR. O experimento constituiu-se de um fatorial 6 x 2, delineado em blocos ao acaso, com três repetições, sendo seis doses de S: 0, 10, 20, 30, 40 e 50 mg kg-1, na forma de gesso agrícola e duas doses de P: 300 e 600 mg kg-1 de P2O5. Nos vasos foram transplantadas mudas de morango variedade Albion, cultivadas por 170 dias. Os frutos foram colhidos e pesados ao longo do experimento e a parte aérea ao final do experimento. A parte aérea e os frutos foram secos, pesados, moídos e analisados em relação ao teor de S, Ca e P. A produção de frutos de morango foi influenciada pelas doses de S, sendo que a maior produtividade foi alcançada na dose de 60 mg kg-1 de S com aplicação de 300 mg kg-1 de P e na aplicação de 600 mg kg-1 de P combinada com a dose de 37 mg kg-1 de S. There are several studies on plant responses to Sulfur (S, but few are specific to the strawberry crop. The requirement for nutrients and the nutritional status of plants is a particular attribute of each species that should be taken into account when determining the plant’s nutritional demand. The objective of this study was to evaluate the application of S and phosphate (P rates in the development and productivity of strawberry crops. An experiment was conducted in a greenhouse in pots containing 2 kg soil (Oxisol in Guarapuava city of Paraná State. The experiment consisted of a 6 × 2 factorial outlined

  11. Uranium potential of precambrian rocks in the Raft River area of northwestern Utah and south-central Idaho. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Black, B.A.

    1980-09-01

    A total of 1214 geochemical samples were collected and analyzed. The sampling media included 334 waters, 616 stream sediments, and 264 rocks. In addition, some stratigraphic sections of Elba and Yost Quartzites and Archean metasedimentary rock were measured and sampled and numerous radiation determinations made of the various target units. Statistical evaluation of the geochemical data permitted recognition of 156 uranium anomalies, 52 in water, 79 in stream sediment, and 25 in rock. Geographically, 68 are located in the Grouse Creek Mountains, 43 in the Raft River Mountains, and 41 in the Albion Range. Interpretation of the various data leads to the conclusion that uranium anomalies relate to sparingly and moderately soluble uraniferous heavy minerals, which occur as sparse but widely distributed magmatic, detrital, and/or metamorphically segregated components in the target lithostratigraphic units. The uraniferous minerals known to occur and believed to account for the geochemical anomalies include allanite, monazite, zircon, and apatite. In some instances samarskite may be important. These heavy minerals contain uranium and geochemically related elements, such as Th, Ce, Y, and Zr, in sufficient quantities to account for both the conspicuous lithologic preference and the generally observed low amplitude of the anomalies. The various data generated in connection with this study, as well as those available in the published literature, collectively support the conclusion that the various Precambrian W and X lithostratigraphic units pre-selected for evaluation probably lack potential to host important Precambrian quartz-pebble conglomerate uranium deposits. Moreover it is also doubted that they possess any potential to host Proterozoic unconformity-type uranium deposits.

  12. Hidden symmetry of small spherical viruses and organization principles in "anomalous" and double-shelled capsid nanoassemblies.

    Science.gov (United States)

    Rochal, S B; Konevtsova, O V; Myasnikova, A E; Lorman, V L

    2016-09-29

    We propose the principles of structural organization in spherical nanoassemblies with icosahedral symmetry constituted by asymmetric protein molecules. The approach modifies the paradigmatic geometrical Caspar and Klug (CK) model of icosahedral viral capsids and demonstrates the common origin of both the "anomalous" and conventional capsid structures. In contrast to all previous models of "anomalous" viral capsids the proposed modified model conserves the basic structural principles of the CK approach and reveals the common hidden symmetry underlying all small viral shells. We demonstrate the common genesis of the "anomalous" and conventional capsids and explain their structures in the same frame. The organization principles are derived from the group theory analysis of the positional order on the spherical surface. The relationship between the modified CK geometrical model and the theory of two-dimensional spherical crystallization is discussed. We also apply the proposed approach to complex double-shelled capsids and capsids with protruding knob-like proteins. The introduced notion of commensurability for the concentric nanoshells explains the peculiarities of their organization and helps to predict analogous, but yet undiscovered, double-shelled viral capsid nanostructures.

  13. Heel pain in psoriatic arthropathy: Analysis of a series of 291 patients.

    Science.gov (United States)

    Morales Ivorra, Isabel; Juárez López, Pablo; López de Recalde, Mercè; Carvalho, Pedro David; Rodriguez Moreno, Jesus

    2017-05-30

    To determine the prevalence of heel pain in a series of patients with psoriatic arthritis (PsA). Cross-sectional, observational and retrospective study of a series of 347 patients. All patients fulfilled the CASPAR criteria for PsA and 291 had a clinically significant history of heel pain. The statistical analysis was performed using chi-square test, ANOVA and binary logistic regression. Thirty-five percent of the patients had clinically significant heel pain. A significant association was established between an early onset of skin and joint involvement in the disease and the development of heel pain. However, no significant correlation was found between disease duration and the presence of heel pain. History of dactylitis and PsA in first-degree family members was also statistically associated with this complication. Clinically significant heel pain was recorded in one third of the patients in this series. There was a statistically significant association with dactylitis, PsA in first-degree family members and an earlier onset of joint and skin disease. Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.

  14. Heavy oil and bitumen : thinking caps on : researchers look at new and greener ways to get at the heavy oil prize

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, L.

    2008-01-15

    New steam stimulation processes developed by the Alberta Ingenuity Centre for In Situ Energy were discussed. The J-well and gravity-assisted steam stimulation (JAGD) process uses a steam injection well located within the top few metres of a reservoir and a production well comprised of an inclined J-shaped well. JAGD is a transitional cold production-to-thermal-production technology. High pressure steam is used to heat and loosen the bitumen so that it flows to the producer well below. The configuration was designed to cut through mud and shale layers and is suitable for poor quality reservoirs. Simulations conducted in Athabasca reservoirs have demonstrated that JAGD uses approximately 75 per cent of the steam typically used in steam assisted gravity drainage (SAGD) processes. The iSAGD process was designed to reposition parallel wells in order to increase oil mobility. Researchers at the centre are also investigating a catalytic air-stream process called CASPAR which aims to upgrade oil from 10 degrees API to 16 degrees API within the reservoir. The process involves a mixture of heat, catalyst hydrogen, steam, air and water in the reservoir. The process leaves heavier ends of oil underground as well as fractions of greenhouse gases (GHGs). Research is also being conducted on expanding-solvent SAGD (ES-SAGD) a process that adds butane to steam in order to reduce water use. 3 figs.

  15. ["Dieu et cerveau, rien que Dieu et cerveau!" Johann Gottfried von Herder (1744-1803) and the neurosciences of this time].

    Science.gov (United States)

    Stahnisch, Frank

    2007-01-01

    The impact of Johann Gottfried von Herder on the broad spectrum of the history of ideas can hardly be estimated by separate categories derived from individual disciplines. It transcends the spheres of philosophy, theology, historiography and even medical anthropology--also because Herder, unlike many of his contemporary philosophers and hommes de lettres, was particularly interested in the neurophysiological and -anatomical investigations of his time. Herder's universal interest in human learning is reflected in numerous personal contacts to contemporary academic scholars and natural scientists, such as the Swiss theologian Johann Caspar Lavater, whose physiognomic doctrine mapped out a comprehensive research programme on character analysis, or the Mainz anatomist Samuel Thomas von Soemmering. Herder tightly received the latter's assumption about the interplay between the human soul and the anatomy of the brain. In this article, it shall be demonstrated that Herder's neurophilosophy was primarily influenced by a "pandynamic assumption of nature" and that it designated the brain centrally as a "working tool of God"--right between the human faculties of rationality, feeling and bodily development. The attractiveness of this concept to both basic brain research and clinical neurology was a result of his anthropological approach which combined latest developments in the natural sciences with a central perspective on the human sciences.

  16. Folding into being: early embryology and the epistemology of rhythm.

    Science.gov (United States)

    Wellmann, Janina

    2015-03-01

    Historians have often described embryology and concepts of development in the period around 1800 in terms of "temporalization" or "dynamization". This paper, in contrast, argues that a central epistemological category in the period was "rhythm", which played a major role in the establishment of the emerging discipline of biology. I show that Caspar Friedrich Wolff's epigenetic theory of development was based on a rhythmical notion, namely the hypothesis that organic development occurs as a series of ordered rhythmical repetitions and variations. Presenting Christian Heinrich Pander's and Karl Ernst von Baer's theory of germ layers, I argue that Pander and Baer regarded folding as an organizing principle of ontogenesis, and that the principle's explanatory power stems from their understanding of folding as a rhythmical figuration. In a brief discussion of the notion of rhythm in contemporary music theory, I identify an underlying physiological epistemology in the new musical concept of rhythm around 1800. The paper closes with a more general discussion of the relationship between the rhythmic episteme, conceptions of life, and aesthetic theory at the end of the eighteenth century.

  17. The Freedom of the Woods: Antiquarian Landscapes and Politics

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    Ülrike Sommer

    2007-11-01

    Full Text Available Dark and deep mysterious woods or forests figure prominently in the works of the German Romantic School (ca. 1790–1840. The novellas, poems and novels of Josef von Eichendorff (1788–1857 and especially of Ludwig Tieck (1773–1853 portray the “Loneliness of the woods” (Waldeinsamkeit that can be both a threat to personal identity, and a refuge from the complications and ugliness of modern life, where the beginning of industrialization was endangering traditional social structures and changing urban and rural environments. Such dark and deep woods also figure prominently in Grimm’s fairy tales (first edition 1812–15 and, perhaps are best known, from the paintings of Caspar-David Friedrich (1744–1840. Descriptions of these landscapes, and especially of ‘majestic woodlands’ also appear in accounts of prehistoric monuments, and indeed, could be used to help in the discovery of these monuments (see below. But are these Romantic woodlands just a new type of landscape, perceived for the first time because of a new aesthetic (Schama 1996? Or do they also convey another meaning? In this article, I am going to look at the way in which the relations between humans and their environment were interpreted, and then how this was used in the interpretation of archaeological finds. In the early nineteenth century some antiquarian texts conspicuously used landscapes to convey political messages.

  18. A Recount of Sunspot Groups on Staudach's Drawings

    Science.gov (United States)

    Svalgaard, Leif

    2017-01-01

    We have examined the more than 1100 drawings of the solar disk made by the German amateur astronomer Johann Caspar Staudach during 1749 - 1799 and counted the spots on each image. Using the modern perception of how to group spots into active regions, we regrouped the spots as a modern observer would. The resulting number of groups was found to be higher on average by 25 % than the first count of groups performed by Wolf in 1857, which was used by Hoyt and Schatten ( Solar Phys. 181, 491, 1998) in their construction of the group sunspot number. Compared to other observers at the time, Staudach's drawings have a very low average number, about two, of spots per group, possibly indicating an inferior telescope that probably suffered from spherical and chromatic aberration, as would be typical of amateur telescopes of the day. We have initiated an ongoing project aiming at observing sunspots with antique telescopes having similar defects in order to determine the factor necessary to bring the Staudach observations onto a modern scale.

  19. A Recount of Sunspot Groups on Staudach's Drawings

    CERN Document Server

    Svalgaard, Leif

    2015-01-01

    We have examined the more than 1100 drawings of the solar disk made by the German astronomy amateur Johann Caspar Staudach during 1749-1799 and counted the spots on each image. Using the modern perception of how to group spots into active regions we regrouped the spots as a modern observer would. The resulting number of groups was found to be on average 25% higher than the first count of groups performed by Wolf in 1857, and used by Hoyt and Schatten in their construction of the Group Sunspot Number. Compared to other observers at the time, Staudach's drawings have a very low average number, ~2, of spots per group, possibly indicating an inferior telescope likely suffering from spherical and chromatic aberration as would typical of amateur telescopes of the day. We have initiated an ongoing project aiming at observing sunspots with antique telescopes having similar defects in order to determine the factor necessary to bring the Staudach observations onto a modern scale.

  20. Disentangling the response of streamflow to forest management and climate

    Science.gov (United States)

    Dymond, S.; Miniat, C.; Bladon, K. D.; Keppeler, E.; Caldwell, P. V.

    2016-12-01

    Paired watershed studies have showcased the relationships between forests, management, and streamflow. However, classical analyses of paired-watershed studies have done little to disentangle the effects of management from overarching climatic signals, potentially masking the interaction between management and climate. Such approaches may confound our understanding of how forest management impacts streamflow. Here we use a 50-year record of streamflow and climate data from the Caspar Creek Experimental Watersheds (CCEW), California, USA to separate the effects of forest management and climate on streamflow. CCEW has two treatment watersheds that have been harvested in the past 50 years. We used a nonlinear mixed model to combine the pre-treatment relationship between streamflow and climate and the post-treatment relationship via an interaction between climate and management into one equation. Our results show that precipitation and potential evapotranspiration alone can account for >95% of the variability in pre-treatment streamflow. Including management scenarios into the model explained most of the variability in streamflow (R2 > 0.98). While forest harvesting altered streamflow in both of our modeled watersheds, removing 66% of the vegetation via selection logging using a tractor yarding system over the entire watershed had a more substantial impact on streamflow than clearcutting small portions of a watershed using cable-yarding. These results suggest that forest harvesting may result in differing impacts on streamflow and highlights the need to incorporate climate into streamflow analyses of paired-watershed studies.

  1. Tratamento cirúrgico das lesões traumáticas do segmento médio-inferior da coluna cervical

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    HERCULANO MARCO ANTONIO

    2000-01-01

    Full Text Available O nível C2 é o mais frequente em lesões traumáticas da coluna cervical, sendo seguido por C5 e C6. Elas ocorrem, mais habitualmente, na terceira década de vida, com incidência decrescente na idade avançada. Como parte destas lesões está localizada nos elementos da coluna anterior, segundo a conceituação de Denis e, levado-se em consideração os estudos biomecânicos do segmento médio--inferior da coluna cervical, bem como os mecanismos que causam estas lesões, elaboramos este estudo, com o intuito de apresentar as técnicas de fusão cervical anterior, com enxerto ósseo e placas de Caspar, Morscher (CSLP e ORION(TM. Mostramos e discutimos as vantagens e desvantagens de cada tipo de fixação anterior, com base nos dados de literatura, evidenciando a melhoria no material de implante e das técnicas de fixação.

  2. Normal Threshold Size of Stimuli in Children Using a Game-Based Visual Field Test.

    Science.gov (United States)

    Wang, Yanfang; Ali, Zaria; Subramani, Siddharth; Biswas, Susmito; Fenerty, Cecilia; Henson, David B; Aslam, Tariq

    2017-06-01

    The aim of this study was to demonstrate and explore the ability of novel game-based perimetry to establish normal visual field thresholds in children. One hundred and eighteen children (aged 8.0 ± 2.8 years old) with no history of visual field loss or significant medical history were recruited. Each child had one eye tested using a game-based visual field test 'Caspar's Castle' at four retinal locations 12.7° (N = 118) from fixation. Thresholds were established repeatedly using up/down staircase algorithms with stimuli of varying diameter (luminance 20 cd/m(2), duration 200 ms, background luminance 10 cd/m(2)). Relationships between threshold and age were determined along with measures of intra- and intersubject variability. The Game-based visual field test was able to establish threshold estimates in the full range of children tested. Threshold size reduced with increasing age in children. Intrasubject variability and intersubject variability were inversely related to age in children. Normal visual field thresholds were established for specific locations in children using a novel game-based visual field test. These could be used as a foundation for developing a game-based perimetry screening test for children.

  3. Environmental law. 2. rev. and enl. ed.; Umweltrecht

    Energy Technology Data Exchange (ETDEWEB)

    Koch, H.J. (ed.) [Hamburg Univ. (Germany). Forschungsstelle Umweltrecht

    2007-07-01

    The text book under consideration already is addressed to lawyers and students of jurisprudence. It enables an introduction into the general environmental law and consists of sixteen autonomous chapters: (a) International law in the field of ecology (Matthias Buck, Roda Verheyen); (b) European and national environmental constitutional law (Johannes Caspar); (c) General environmental administrative law (Ulrich Ramsauer); (d) Pollution abatement law (Hans-Joachim Koch); (e) Water protection law (Silke Laskowski, Cornelia Ziehm); (f) Recycling economy law and waste management law (Martin Dieckmann, Moritz Reese); (g) Nature conservation law (Christian Maass, Peter Schuette); (h) Soil conservation law and contaminated sites law (Nikolaus Herrmann); (i) Energy legal regulations as an instrument of environmental protection (Wolfgang Ewer); (j) Atomic energy law (Klaus Jankowski); (k) Genetic engineering law (Ursula Prall); (l) Law of hazardous materials (Eckhard Pache); (m) Environmental law in planning law (Nikolaus Hermann); (n) Environment and traffic (Philipp Hermann, Ekkehard Hofmann); (o) Agriculture and ecology (Ulf-Henning Moeker); (p) Liberal trade and environmental protection (Matthias Buck).

  4. Psoriasis and psoriatic arthritis in Peruvian aborigines: a report from the GRAPPA 2011 annual meeting.

    Science.gov (United States)

    Toloza, Sergio M A; Vega-Hinojosa, Oscar; Chandran, Vinod; Valle Onate, Rafael; Espinoza, Luis R

    2012-11-01

    To determine the presence of psoriasis and psoriatic arthritis (PsA) in aboriginal people living in the Andean Mountains of Peru. Consecutive patients with psoriasis and PsA attending an arthritis clinic in Juliaca, Puno, Peru, located 3824 m above sea level were examined. The CASPAR (ClASsification of Psoriatic ARthritis) criteria were used for classification of PsA. Diagnosis of psoriasis was confirmed by a dermatologist. Seventeen patients [11 (65%) men and 6 (35%) women] fulfilled classification criteria for PsA; one patient was of European ancestry and is not included in this report. Of the 16 aboriginal patients in this report, 5 were natives of Quechua ancestry and one was native Aymara. At the time of their first clinic visit, no native patient with PsA had a family history of psoriasis or PsA, and all patients exhibited an established disease of long duration and severity. Methotrexate was the drug of choice for all patients; 2 patients are currently receiving biological therapy. Contrary to what has been reported in the literature, both psoriasis and PsA are present in aboriginal people from the Andean Mountains of Peru. More studies are needed to further define the phenotype of these disorders, as well as the pathogenetic role of genetic and environmental factors.

  5. Development and calibration of a load sensing cervical distractor capable of withstanding autoclave sterilization.

    Science.gov (United States)

    Demetropoulos, C K; Truumees, E; Herkowitz, H N; Yang, K H

    2005-05-01

    In surgery of the cervical spine, a Caspar pin distractor is often used to apply a tensile load to the spine in order to open up the disc space. This is often done in order to place a graft or other interbody fusion device in the spine. Ideally a tight interference fit is achieved. If the spine is over distracted, allowing for a large graft, there is an increased risk of subsidence into the endplate. If there is too little distraction, there is an increased risk of graft dislodgement or pseudoarthrosis. Generally, graft height is selected from preoperative measurements and observed distraction without knowing the intraoperative compressive load. This device was designed to give the surgeon an assessment of this applied load. Instrumentation of the device involved the application of strain gauges and the selection of materials that would survive standard autoclave sterilization. The device was calibrated, sterilized and once again calibrated to demonstrate its suitability for surgical use. Results demonstrate excellent linearity in the calibration, and no difference was detected in the pre- and post-sterilization calibrations.

  6. Psoriatic arthritis in patients with psoriasis: evaluation of clinical and epidemiological features in 133 patients followed at the University Hospital of Brasília Artrite psoriásica em pacientes com psoríase: avaliação de características clínicas e epidemiológicas em 133 pacientes atendidos no Hospital Universitário de Brasília

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    Jamille Nascimento Carneiro

    2012-08-01

    Full Text Available BACKGROUND: Psoriatic arthritis is an inflammatory arthritis associated with psoriasis. Its prevalence in patients with psoriasis varies from 7 to 42% but its exact prevalence is unknown. OBJECTIVES: Considering the lack of national data related to its diagnosis in patients with psoriasis, this study aims to describe the clinical, laboratorial and radiological manifestations of psoriatic arthritis in these patients. METHODS: We evaluated 133 patients with psoriasis, treated as outpatients. These patients were asked to fill in the forms with data about the disease and were submitted to a clinical evaluation by a dermatologist and a rheumatologist. Suspected cases of arthritis were referred for further investigation and were classified according to presence or absence of psoriatic arthritis according to CASPAR criteria. RESULTS: The number of patients with psoriatic arthritis was 47 (35%, 17 of them were new cases. There was no difference between the groups regarding the type of psoriasis, nail involvement, presence of scalp lesions and psoriatic arthritis. Patients with psoriatic arthritis had more enthesitis and dactylitis (46.7% than those without arthritis. CONCLUSIONS: Despite the high prevalence of arthritis found, we know that results from epidemiological studies are variable, which limits their use and interpretation. We conclude that more studies are needed to draw a profile of rheumatic manifestations in our population of psoriasis patients.FUNDAMENTOS: A artrite psoriásica é uma artrite inflamatória associada à psoríase. Sua prevalência nos pacientes com psoríase de 7 a 42% mas sua exata prevalência ainda é desconhecida. OBJETIVOS: Considerando a escassez de dados nacionais relacionados ao seu diagnóstico em pacientes com psoríase o presente estudo visa descrever o quadro clínico, laboratorial e radiológico da doença nesses pacientes. MÉTODOS: Foram avaliados 133 pacientes com diagnóstico de psoríase acompanhados no

  7. Christology and Christianity: The theological power of the threefold office in Lord’s Day 12

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    Erik A. de Boer

    2013-06-01

    Full Text Available The concept of the threefold office of Jesus was developed in the explanation of the name Christ. The three distinct offices of king, priest and prophet in Israel are thought to be united in the one Messiah. Since the unity of all three offices in one person is not found in so many words in one specific text from the Bible, it is regarded as a theological concept. As such it was developed for the first time in the Heidelberg Catechism (HC. This article traces the development of the exposition of the Apostles’ Creed in earlier Lutheran and reformed catechisms. Special attention is devoted to the one by Johannes Brenz, which was used in the Palatinate before 1563. The main source of the new Catechism of Heidelberg is the Catechismus minor by Zacharias Ursinus, who himself may have been influenced by Martin Bucer and John Calvin and their respective Catechisms. A special feature of the HC is question and answer (Q/A 32, devoted to a parallel exposition of the name Christian. Caspar Olevianus’ work Vester Grund (A Firm Foundation is read as a contemporary commentary on the exposition of the Creed. The catechetical power of the concept of Christ’s threefold office is finally demonstrated in its use in systematic theologies as by Gerrit Immink and Michael Welker, especially in their Christologies.Die konsep van die drievoudige amp van Jesus is ontwikkel in die verklaring van die naam Christus. Die drie onderskeie ampte in Israel, dié van koning, priester en profeet, word gesien as verenig in die Messias. Aangesien die vereniging van al drie ampte in een persoon nie soseer in een spesifieke Bybelteks gevind word nie, word dit as ’n teologiese konsep beskou. Dit is sodanig vir die eerste keer in die Heidelbergse Kategismus (HK ontwikkel. Hierdie artikel ondersoek die ontwikkeling van die uiteensetting van die Apostoliese Geloofsbelydenis in die konteks van vroeëre Lutherse en gereformeerde kategismusse. Daar word veral na Johannes Brenz se

  8. Intra-articular therapy with infliximab in psoriatic arthritis: efficacy and safety in refractory monoarthritis

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    A. Minosi

    2011-06-01

    Full Text Available Objective: To evaluate efficacy and safety of intra-articular therapy (IA with infliximab (IFX, in patients with psoriatic arthritis (PsA and refractory monoarthritis. Methods: Four male and 1 female aged from 25 to 71 years and disease duration from 1 to 25 years, affected by PsA (CASPAR criteria were observed . All patients were treated with immunomodulators (methotrexate, leflunomide, cyclosporin A, 3/5 with concomitant steroids, 4/5 with NSAID’s. Only 1 patient were treated with IFX 5 mg/kg IV every 6 weeks. Before the IFX injection an amount of synovial fluid was aspired from the inflamed site and the anti-TNF injection was echographic guided. Patients were evaluated at regular intervals through clinical and echographic examination and retreated in case of flare. Results: At follow-up visit after 7 days, in all patients treated with the first injection was detected total regression of the inflammation and no new inflamed synovial fluid was observed; power doppler examination shows reduction of local vascularization. Two patients experienced full remission after 6 months and only one injection, 1 patient (arthritis of the wrist was in remission after 2 injections (3 months of interval. In 2 patients with knee arthritis and important synovial hypertrophy good results obtained after the first injection were not maintained afterwards and second injection was ineffective: these patients were evaluated for surgical intervention. Conclusions: Local injections of IFX were safe and well tolerated in all patients. The efficacy in short term was observed in all cases; our supposition is that presence of synovial hypertrophy is cause of worsening.

  9. PSORIATIC ARTHRITIS: AN ALGORITHM FOR MAKING A DECISION ON THE CHOICE OF MANAGEMENT TACTICS

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    N. A. Shostak

    2015-01-01

    Full Text Available Psoriatic arthritis (PA is a chronic inflammatory disease of the joints, vertebral column, and entheses from a group of seronegative spondyloarthritides, which is observed in patients with psoriasis. In accordance with the 2013 federal clinical guidelines for the management of patients with PA, published by the Russian Society of Dermatovenereologists and Cosmetologists and the Association of Rheumatologists of Russia, its diagnosis should be based on the CASPAR criteria (ClASsification criteria for Psoriatic ARthritis, 2006. The activity of spondylitis in PA is assessed using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI that is a questionnaire containing 6 questions; a numeric rating scale from 0 (“very good” to 10 (“very bad” scores is applied for a response. It is recommended that ultrasound studies and magnetic resonance tomography be used for the early diagnosis of enthesitis in seronegative spondyloarthritides. The Psoriasis Area Severity Index (PASI that takes into account the area of the lesion, the magnitude of erythema, infiltration, and desquamation in different body areas. The early diagnosis of PA and the timely use of disease-modifying antirheumatic therapy are topical problems, as high-activity inflammation may lead to rapid joint destruction, physical limitations, and disability. When the signs of active PA (the presence of one or more swollen and tender joints, and/or 1 or more dactylitides, and/or more enthesitides and/or inflammatory back pain are detected, prompt drug therapy is indicated. The clear compliance of the algorithm for making a decision on treatment policy and the timely assessment of the clinical manifestations of the disease improves prognosis, adherence to treatment, and quality of life.

  10. Oassi sámi noaidevuođa birra Kaspar Peucera čállosis Commentarius de praecipuis divinationum generibus (Wittenberg 1560: Teakstakritihkalaš hámis jorgalusain ja kommentáraiguin

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    Per Pippin Aspaas

    2014-11-01

    Full Text Available The text on Sami shamanism in Caspar Peucer’s Commentarius de praecipuis divinationum generibus (Wittenberg 1560: Critical edition, with translation and commentary. Among the sources dealing with the shamanistic skills of the Sami (formerly Lapponian population, a certain text by Kaspar Peucer has so far been little known. This man of extreme learning was the son-in-law of Philip Melanchthon and a Professor at the University of Wittenberg. A true polyhistor, well versed in Medicine, Geography, Astrology, Theology, etc., Peucer included in his chef-d’oeuvre on divination an elaborate description of the shamanism of the so-called Pilappii. The present article offers a critical edition of this text, based on the editions of Wittenberg 1560 (A, 1572 (B, 1580 (C, as well as Zerbst 1591 (D and Frankfurt 1593 (E. In addition to translations into North Sami and Norwegian (see Appendix, some contextualisation is offered, which can be summarised as follows: A similar testimony on shamanism is found in the Historia de gentibus Septentrionalibus by Olaus Magnus (Rome 1555. However, that text is not elaborate enough to prove that Kaspar Peucer has copied his description from him. It is more likely that some student among the considerable number of Swedes, Finns and Norwegians that were immatriculated at Wittenberg University in the years following the Reformation, presented this account to Peucer. Many details in the account make it strikingly similar to Sami folk narratives that have been assembled several centuries later. For example, the description of maritime Sami by Anders Larsen (1870–1949, the Sami book by Johan Turi (published 1910 and Sami songs (joik that were collected by Jacob Fellman in the 1820’s can be compared with Peucer’s account. Peucer himself, however, categorised the shamanism of the Sami as a form of theomanteia, i.e. a form of magic which he considered to originate not from the true God, but from the Devil.

  11. Prevalence and clinical patterns of psoriatic arthritis in Indian patients with psoriasis

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    Ramesh Kumar

    2014-01-01

    Full Text Available Background: The prevalence and clinical patterns of psoriatic arthritis (PsA varies in different parts of the world and there is little clinical and epidemiological data from the Indian subcontinent. Aims: Our study was designed to evaluate the prevalence and clinical patterns of PsA in Indian patients. Methods: This was a non-interventional, cross-sectional study, in which 1149 consecutive psoriasis patients seen over 1 year were screened for PsA according to classification of psoriatic arthritis (CASPAR criteria. Demographic and disease parameters were recorded including Psoriasis Area and Severity Index (PASI, Nail Psoriasis Severity Index (NAPSI, and number of swollen and tender joints. Results: Among 1149 patients with psoriasis, 100 (8.7% patients had PsA, of which 83% were newly diagnosed. The most common pattern was symmetrical polyarthritis (58%, followed by spondyloarthropathy 49%, asymmetric oligoarthritis (21%, isolated spondyloarthropathy (5%, predominant distal interphalangeal arthritis (3%, and arthritis mutilans (1%. Enthesitis and dactylitis were present in 67% and 26% of cases, respectively. The mean number of swollen and tender joints were 3.63 ± 3.59 (range, 0-22 and 7.76 ± 6.03 (range, 1-26, respectively. Nail changes were present in 87% of the cases. The median PASI and NAPSI of the subjects with PsA was 3.6 and 20, respectively. There was no significant correlation of number of swollen/tender joints with PASI or NAPSI. Conclusion: There is a relatively low prevalence of PsA among Indian psoriasis patients presenting to dermatologists. No correlation was found between the severity of skin and nail involvement and articular disease.

  12. CLINICAL HETEROGENEITY OF EARLY PSORIATIC ARTHRITIS

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    V. V. Badokin

    2016-01-01

    Full Text Available Objective: to reveal the characteristic symptoms and syndromes of early-stage psoriatic arthritis (ePsA, which are pivotal to its early diagnosis.Patients and methods. Fifty-one patients with a PsA duration of less than 2 years (mean 12 months were examined. The diagnosis of PsA was established on the basis of the conventional CASPAR criteria and the Russian criteria developed by the expert method. The conventional current criteria, including the number of tender and swollen joints, DAS28, values of acute-phase indicators, were used to detect inflammatory activity. Skin syndrome was evaluated using the Psoriasis Area and Severity Index (PASI. X-ray study of the hands, distal and proximal feet, pelvis, and other involved joints and MRI of the distal hands/feet were performed. The Maastricht Ankylosing Spondylitis Enthesitis Score (MASES and reduced GUESS were used to assess enthesopathy.Results. The types of articular syndrome in ePsA were identified in accordance of the duration of the disease. The authors determined the characteristic features of arthritis, spondylitis, enthesitis, and dactylitis, their diagnostic value and associations with other manifestations in the first 2 years of PsA. There was a relationship of dermatitis and psoriatic onychopathy to the clinical picture of articular syndrome.Conclusion. ePsA is characterized by marked heterogeneity of articular syndrome with predominantly mono/oligoarthritic and polyarthritic articular syndrome. The significant signs are enthesitis and dactylitis, which serve as risk factors for the unfavorable course of the disease. 

  13. Sensitivity and specificity of plain radiographic features of peripheral enthesopathy at major sites in psoriatic arthritis

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    Helliwell, P.S. [University of Leeds, Academic Unit of Musculoskeletal and Rehabilitation Medicine, Leeds (United Kingdom); Porter, G. [Airedale Hospital NHS Trust, Keighley, West Yorkshire (United Kingdom)

    2007-11-15

    It has been proposed that the defining difference between rheumatoid arthritis and spondyloarthropathy (including psoriatic arthritis) is the initial pathological lesion where the emphasis in psoriatic arthritis is on the enthesis and in rheumatoid arthritis on the synovium. Classical radiological descriptions of seronegative spondyloarthropathy include enthesopathy at major entheseal insertions characterised by erosions and exuberant new bone formation. In this study, the plain radiographic features of spondyloarthropathy are compared between psoriatic arthritis, other spondyloarthropathies and rheumatoid arthritis. The CASPAR study collected clinical, radiological and laboratory data on 588 patients with physician diagnosed psoriatic arthritis and 525 controls with other inflammatory arthritis, 70% of which had rheumatoid arthritis. Plain radiographs of the pelvis and heels were part of the study protocol, although radiographs of other potential entheseal sites such as the knee, elbow and shoulder, were interpreted if available. All radiographs were read blind by two observers working in tandem. Significant differences in entheseal erosion and entheseal new bone formation were found between psoriatic arthritis, ankylosing spondylitis, undifferentiated spondyloarthropathy, rheumatoid arthritis and other diagnoses (entheseal erosion, chi-squared 20.8, p = 0.008; entheseal new bone formation, chi-squared 24.5, p = 0.001). These differences were mainly due to a higher proportion of these features in ankylosing spondylitis. No differences in the plain radiographic features of enthesopathy were found between psoriatic arthritis and rheumatoid arthritis except in the case of entheseal new bone formation at sites of attachment of inguinal ligament, sartorius and rectus femoris muscles to the ilium (OR 3.01, 95% CI 1.13-8.02). Very few subjects with symptomatic heel involvement had radiographic changes and minimal differences were found between those with and without

  14. Classification and clinical assessment

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    F. Cantini

    2012-06-01

    Full Text Available There are at least nine classification criteria for psoriatic arthritis (PsA that have been proposed and used in clinical studies. With the exception of the ESSG and Bennett rules, all of the other criteria sets have a good performance in identifying PsA patients. As the CASPAR criteria are based on a robust study methodology, they are considered the current reference standard. However, if there seems to be no doubt that they are very good to classify PsA patients (very high specificity, they might be not sensitive enough to diagnose patients with unknown early PsA. The vast clinical heterogeneity of PsA makes its assessment very challenging. Peripheral joint involvement is measured by 78/76 joint counts, spine involvement by the instruments used for ankylosing spondylitis (AS, dactylitis by involved digit count or by the Leeds dactylitis index, enthesitis by the number of affected entheses (several indices available and psoriasis by the Psoriasis Area and Severity Index (PASI. Peripheral joint damage can be assessed by a modified van der Heijde-Sharp scoring system and axial damage by the methods used for AS or by the Psoriatic Arthritis Spondylitis Radiology Index (PASRI. As in other arthritides, global evaluation of disease activity and severity by patient and physician and assessment of disability and quality of life are widely used. Finally, composite indices that capture several clinical manifestations of PsA have been proposed and a new instrument, the Psoriatic ARthritis Disease Activity Score (PASDAS, is currently being developed.

  15. Himmelsblau. Bemerkungen zum Thema „Farben“ in Humboldts Alterswerk Kosmos. Entwurf einer physischen Weltbeschreibung

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    Petra Werner

    2006-04-01

    Full Text Available Articel in German, Abstracts in English and German.For the greater part of his life, Alexander von Humboldt was interested in colour phenomena which he observed in nature. These observations led him to do research into phenomena such as the blue colour of the sky, enigmatic dust and hail, and the colour of plants. Humboldt corresponded with many scientists about the connection between sunlight and the creation of colours, about coloured shadows, the Blue Cave in Capri, the colour of stars, plants etc. Claude-Louis Berthollet developed a model for the composition of a blue colour (Indigo, a technology which was of great importance to the textile industry.The present paper focuses on Humboldt’s interest in the blue colour of the sky, which he shared with artists, writers and scientists like Johann Wolfgang von Goethe, Christian Gottfried Lichtenberg, Caspar David Friedrich and Horace Bénédict de Saussure. During his travels in South America, Humboldt used Saussure’s cyanometer to determine the intensity of the blue colour of the sky. Later he corresponded about this instrument with his friend François Arago who had invented a cyanometer based on chromatic polarisation. While Humboldt was working on his “Cosmos”, Arago explained to his friend the latest results in physics, especially in polarography. Towards the end of his life, Humboldt corresponded with the painter J. G. Schall and admitted that he had somewhat lost his interest in the physical explanation of the blue colour of the sky.

  16. 50 years of fiber diffraction.

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    Holmes, Kenneth C

    2010-05-01

    In 1955 Ken Holmes started working on tobacco mosaic virus (TMV) as a research student with Rosalind Franklin at Birkbeck College, London. Afterward he spent 18months as a post doc with Don Caspar and Carolyn Cohen at the Children's Hospital, Boston where he continued the work on TMV and also showed that the core of the thick filament of byssus retractor muscle from mussels is made of two-stranded alpha-helical coiled-coils. Returning to England he joined Aaron Klug's group at the newly founded Laboratory of Molecular Biology in Cambridge. Besides continuing the TMV studies, which were aimed at calculating the three-dimensional density map of the virus, he collaborated with Pringle's group in Oxford to show that two conformation of the myosin cross-bridge could be identified in insect flight muscle. In 1968 he opened the biophysics department at the Max Planck Institute for Medical Research in Heidelberg, Germany. With Gerd Rosenbaum he initiated the use of synchrotron radiation as a source for X-ray diffraction. In his lab the TMV structure was pushed to 4A resolution and showed how the RNA binds to the protein. With his co-workers he solved the structure of g-actin as a crystalline complex and then solved the structure of the f-actin filament by orientating the g-actin structure so as to give the f-actin fiber diffraction pattern. He was also able to solve the structure of the complex of actin with tropomyosin from fiber diffraction.

  17. Clinical features and multidisciplinary approaches to dementia care

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    Gr

    2011-05-01

    Full Text Available Jacob HG Grand¹, Sienna Caspar², Stuart WS MacDonald11Department of Psychology, University of Victoria, Victoria, BC, Canada; 2Interdisciplinary Graduate Studies, University of British Columbia, Vancouver, BC, CanadaAbstract: Dementia is a clinical syndrome of widespread progressive deterioration of cognitive abilities and normal daily functioning. These cognitive and behavioral impairments pose considerable challenges to individuals with dementia, along with their family members and caregivers. Four primary dementia classifications have been defined according to clinical and research criteria: 1 Alzheimer’s disease; 2 vascular dementias; 3 frontotemporal dementias; and 4 dementia with Lewy bodies/Parkinson’s disease dementia. The cumulative efforts of multidisciplinary healthcare teams have advanced our understanding of dementia beyond basic descriptions, towards a more complete elucidation of risk factors, clinical symptoms, and neuropathological correlates. The characterization of disease subtypes has facilitated targeted management strategies, advanced treatments, and symptomatic care for individuals affected by dementia. This review briefly summarizes the current state of knowledge and directions of dementia research and clinical practice. We provide a description of the risk factors, clinical presentation, and differential diagnosis of dementia. A summary of multidisciplinary team approaches to dementia care is outlined, including management strategies for the treatment of cognitive impairments, functional deficits, and behavioral and psychological symptoms of dementia. The needs of individuals with dementia are extensive, often requiring care beyond traditional bounds of medical practice, including pharmacologic and non-pharmacologic management interventions. Finally, advanced research on the early prodromal phase of dementia is reviewed, with a focus on change-point models, trajectories of cognitive change, and threshold models of

  18. Implications of Increasing Forest Density and Vegetation Water Demand on Drought Impacts in California Montane Forest

    Science.gov (United States)

    Saksa, P. C.; Safeeq, M.; Dymond, S.

    2016-12-01

    Vegetation density has been increasing over the past 30 years at mid-elevation southern Sierra mixed-conifer catchments and northern California coastal conifer catchments, as shown from Landsat mean annual values of the Normalized Difference Vegetation Index (NDVI). Forest vegetation in these regions is being maintained or even increased during the recent drought, despite record low precipitation levels statewide and heavy tree mortality at lower elevation Sierra pine-dominated forests. The increase in vegetation density suggests an increase in forest water use, exacerbating the effects of the drought on runoff and water supply. Between 1984 and 2015, mean annual NDVI increased in the southern Sierra from 0.47 to 0.56 (+19%) in the Providence Creek basin (1730-2115m elevation) and from 0.53 to 0.62 (+17%) in Bull Creek basin (2145-2490m), while NDVI increased along the northern California coast from 0.75 to 0.88 (+17%) in the Caspar Creek basin (40-300m). Previous research has shown an exponential relationship exists between NDVI and measured annual evapotranspiration (ET), indicating even greater increases in ET than NDVI over the three decades. This increase in vegetation has also led to more competition for plant available water, and can be used to explain the large tree mortality occurring in the pine forests at lower elevations, which did not occur during previous drought periods. Preliminary results of a hydro-ecological model, RHESSys, suggest intensive vegetation treatments in these regions can reduce evapotranspiration and modify the catchment-scale water balance. Forest management strategies for implementation of thinning and fuels treatments to reduce forest density may be effective in limiting vegetation mortality during future drought events.

  19. La transposición como procedimiento artístico en la obra de Peter Rostovsky

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    María Guillermina Fressoli

    2011-06-01

    Full Text Available Este trabajo indaga la obra del artista Peter Rostovsky, el uso de la transposición  como recurso estético. El caso ofrece un ejemplo de cómo la transposición, en el marco de una tendencia artística que trabaja desde la deconstrucción de diferentes códigos o representaciones culturales, puede devenir un recurso que apela a una referencia compartida con un eventual espectador a fin de componer un discurso poético. Como hipótesis se considera que a través de este procedimiento el artista  reflexiona sobre el desplazamiento de hábitos de visibilidad y percepción en la cultura contemporánea. Este dispositivo, que revisita diferentes obras modernas, formula un enunciado que reflexiona sobre el estatuto de la experiencia en la actualidad. Para desarrollar el problema que el caso plantea se indagará específicamente sobre la serie Ephifany Models en la que el artista reelabora la obra del pintor Caspar Friedrich y, a través de él, los recursos pictóricos del romanticismo alemán. En esa reelaboración Rostovsky traslada el texto decimonónico a una nueva materia significante, este desplazamiento que el artista establece entre el discurso romántico y los recursos del arte contemporáneo comprometen valoraciones sociales y culturales que producen un cambio de sentido del texto fuente constituyendo una transposición.

  20. Mosquito infection responses to developing filarial worms.

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    Sara M Erickson

    Full Text Available Human lymphatic filariasis is a mosquito-vectored disease caused by the nematode parasites Wuchereria bancrofti, Brugia malayi and Brugia timori. These are relatively large roundworms that can cause considerable damage in compatible mosquito vectors. In order to assess how mosquitoes respond to infection in compatible mosquito-filarial worm associations, microarray analysis was used to evaluate transcriptome changes in Aedes aegypti at various times during B. malayi development. Changes in transcript abundance in response to the different stages of B. malayi infection were diverse. At the early stages of midgut and thoracic muscle cell penetration, a greater number of genes were repressed compared to those that were induced (20 vs. 8. The non-feeding, intracellular first-stage larvae elicited few differences, with 4 transcripts showing an increased and 9 a decreased abundance relative to controls. Several cecropin transcripts increased in abundance after parasites molted to second-stage larvae. However, the greatest number of transcripts changed in abundance after larvae molted to third-stage larvae and migrated to the head and proboscis (120 induced, 38 repressed, including a large number of putative, immunity-related genes (approximately 13% of genes with predicted functions. To test whether the innate immune system of mosquitoes was capable of modulating permissiveness to the parasite, we activated the Toll and Imd pathway controlled rel family transcription factors Rel1 and Rel2 (by RNA interference knockdown of the pathway's negative regulators Cactus and Caspar during the early stages of infection with B. malayi. The activation of either of these immune signaling pathways, or knockdown of the Toll pathway, did not affect B. malayi in Ae. aegypti. The possibility of LF parasites evading mosquito immune responses during successful development is discussed.

  1. The Laboratoire Souterrain Bas Bruit (lsbb) In Rustrel-pays D'apt (france): A Unique Opportunity For Low-noise Underground Science

    Science.gov (United States)

    Waysand, G.; Gaffet, S.; Virieux, J.; Chwala, A.; Auguste, M.; Boyer, D.; Cavaillou, A.; Guglielmi, Y.; Rodrigues, D.

    The former underground lauching control room 1 of the ground based component of the french nuclear missile system has been decommissioned. This installation has been designed and built to remain operational even in case of a near-by nuclear blast. As a result it is robust to radioactive clouds, thermal and mechanical waves as well as electromagnetic pulses. The whole installation has been turned progressively into a cross disciplinary underground laboratory LSBB. LSBB is, so far, a unique low noise underground set-up because of its initial conception and its location in the regional parc of Luberon far from large cities, industries and heavy car traffic. The galleries of LSBB, horizontally accessible from the surface, are buried in the south of the Albion Plateau, northward Aix-en-Provence. Their ensemble is almost flat with a 2% slope and a total length larger than 3.5km under the karstic calcareous "Grande Montagne". The deepest point is 500m below the surface. At this depth, a huge and non conven- tional shielded cylindrical capsule with an horizontal axis was installed. It measures 28m long with 9m in diameter surrounded by 1cm of stainless steel plus 2m of rein- forced concrete. This is indeed a very large Faraday cage but with µmetal, 1250m3 no in volume with a residual electromagntic noise lower than 2fT/ Hz above 10Hz, the present limit of the residual noise of the SQUID magnetometer we have used. As a result, earth magnetic field fluctuations can be recorded even at a very low noise level with SQUIDS (superconducting quantum interferometric devices) at liquid he- lium temperature. Taking advantage of the "V" geometry of the main gallery, a broad- band underground seismic array has been designed with 5 STS2 sensors and is de- ployed since the beginning of 2001. Simultaneously, magnetic measurements are done with a low Tc SQUID magnetometer jointly to the seismic recordings. The spectral noise calibration of the LSBB will be presented and discussed as well

  2. Yields and resistance of strawberry cultivars to crown and root diseases in the field, and cultivar responses to pathogens under controlled environment conditions

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    Xiangling FANG

    2012-05-01

    Full Text Available Devastating outbreaks of crown and root diseases have impacted severely on commercial strawberry production in Western Australia (W.A.. Studies were conducted to evaluate the yields, and resistance of three commercial strawberry cultivars to crown and root diseases, both in fumigated and non-fumigated field beds, and to determine the responses of eight commercial cultivars to individual pathogens under controlled conditions. In the field, cv. Camino Real showed the greatest fruit yield both in fumigated and non-fumigated beds, and was the most disease-resistant cultivar. Each cultivar had a greater fruit yield and a lower amount of plant decline in fumigated beds, compared with non-fumigated beds. Both for fumigated and non-fumigated beds, the amount of plant decline increased from August to November, particularly in non-fumigated beds. Under controlled conditions, cv. Festival was most resistant and cv. Camarosa most susceptible to wilt-causing Fusarium oxysporum. Against binucleate Rhizoctonia AG-A, Cylindrocarpon destructans and Phoma exigua, cv. Festival was most resistant and cv. Aromas most susceptible. Cultivar Camino Real was the most resistant to Gnomonia fructicola and Phytophthora cactorum and cv. Festival most resistant to Pythium ultimum. Against Macrophomina phaseolina, cv. Albion was the most resistant with cv. Camarosa the most susceptible. Cultivar Camarosa, the most widely grown cultivar in W.A., was most susceptible to F. oxysporum, while cv. Camino Real was resistant to F. oxysporum both in the field and the controlled environment conditions. Cultivar Festival is the most resistant cultivar to F. oxysporum and a range of different pathogens. The Australian bred cv. Juliette was as susceptible as cv. Camarosa to F. oxysporum, but relatively resistant to binucleate Rhizoctonia AG-A. This is the first study, not only to define the relative yield potentials of different cultivars in a situation where crown and root disease

  3. Molecular characterization and experimental host range of an isolate of Wissadula golden mosaic St. Thomas virus.

    Science.gov (United States)

    Collins, A M; Mujaddad-ur-Rehman, Malik; Brown, J K; Reddy, C; Wang, A; Fondong, V; Roye, M E

    2009-12-01

    Partial genome segments of a begomovirus were previously amplified from Wissadula amplissima exhibiting yellow-mosaic and leaf-curl symptoms in the parish of St. Thomas, Jamaica and this isolate assigned to a tentative begomovirus species, Wissadula golden mosaic St. Thomas virus. To clone the complete genome of this isolate of Wissadula golden mosaic St. Thomas virus, abutting primers were designed to PCR amplify its full-length DNA-A and DNA-B components. Sequence analysis of the complete begomovirus genome obtained, confirmed that it belongs to a distinct begomovirus species and this isolate was named Wissadula golden mosaic St. Thomas virus-[Jamaica:Albion:2005] (WGMSTV-[JM:Alb:05]). The genome of WGMSTV-[JM:Alb:05] is organized similar to that of other bipartite Western Hemisphere begomoviruses. Phylogenetic analyses placed the genome components of WGMSTV-[JM:Alb:05] in the Abutilon mosaic virus clade and showed that the DNA-A component is most closely related to four begomovirus species from Cuba, Tobacco leaf curl Cuba virus, Tobacco leaf rugose virus, Tobacco mottle leaf curl virus, and Tomato yellow distortion leaf virus. The putative Rep-binding-site motif in the common region of WGMSTV-[JM:Alb:05] was observed to be identical to that of Chino del tomate virus-Tomato [Mexico:Sinaloa:1983], Sida yellow mosaic Yucatan virus-[Mexico:Yucatan:2005], and Tomato leaf curl Sinaloa virus-[Nicaragua:Santa Lucia], suggesting that WGMSTV-[JM:Alb:05] is capable of forming viable pseudo-recombinants with these begomoviruses, but not with other members of the Abutilon mosaic virus clade. Biolistic inoculation of test plant species with partial dimers of the WGMSTV-[JM:Alb:05] DNA-A and DNA-B components showed that the virus was infectious to Nicotiana benthamiana and W. amplissima and the cultivated species Phaseolus vulgaris (kidney bean) and Lycopersicon esculentum (tomato). Infected W. amplissima plants developed symptoms similar to symptoms observed under field

  4. Groundwater geochemistry of the Yucatan Peninsula, Mexico: Constraints on stratigraphy and hydrogeology

    Science.gov (United States)

    Perry, Eugene; Paytan, Adina; Pedersen, Bianca; Velazquez-Oliman, Guadalupe

    2009-03-01

    SummaryWe report 87Sr/ 86Sr and ion concentrations of sulfate, chloride, and strontium in the groundwater of the northern and central Yucatan Peninsula, Mexico. Correlation between these data indicates that ejecta from the 65.95 m.y. old Chicxulub impact crater have an important effect on hydrogeology, geomorphology, and soil development of the region. Ejecta are present at relatively shallow subsurface depths in north-central Yucatan and at the surface along the Rio Hondo escarpment in southeast Quintana Roo, where they are referred to as the Albion Formation. Anhydrite/gypsum (and by inference celestite) are common in impact ejecta clasts and in beds and cements of overlying Paleocene and Lower Eocene rocks cored around the margin of the crater. The sulfate-rich minerals that are found in rocks immediately overlying the impact ejecta blanket, may either be partially mobilized from the ejecta layer itself or may have been deposited after the K/T impact event in an extensive pre-Oligocene shallow sea. These deposits form a distinctive sedimentary package that can be easily traced by the Eocene-Cretaceous 87Sr/ 86Sr signal. A distinct Sr isotopic signature and high SO 4/Cl ratios are observed in groundwater of northwestern and north-central Yucatan that interacts with these rocks. Moreover, the distribution of the gypsum-rich stratigraphic unit provides a solution-enhanced subsurface drainage pathway for a broad region characterized by dissolution features (poljes) extending from Chetumal, Quintana Roo to Campeche, Campeche. The presence of gypsum quarries in the area is also consistent with a sulfate-rich stratigraphic "package" that includes ejecta. The distinctive chemistry of groundwater that has been in contact with evaporite/ejecta can be used to trace flow directions and confirms a groundwater divide in the northern Peninsula. Information about groundwater flow directions and about deep subsurface zones of high permeability is useful for groundwater and

  5. Obituary: R(oyal) Glenn Hall, 1921-2004

    Science.gov (United States)

    McCarthy, Dennis Dean

    2004-12-01

    R. Glenn Hall died on 25 June 2004 following a battle with prostate cancer. His contributions to the determination of the frequency corresponding to an energy level transition in the Cesium atom led to the definition of the length of the second and formed the basis for precise modern timekeeping. Glenn was born on 23 June 1921 in Koloa, Hawaii, and together with a brother and three sisters, grew up in Albion, Michigan. His father was a professor of political science at Albion College. He graduated from Park College in Parkville, Missouri with a degree in mathematics in 1941. He served as a corpsman in the U. S. Navy during World War II, and went on to earn a PhD at the University of Chicago in 1949. Glenn joined the faculty at the University of Chicago as an instructor from 1949 through 1952 and became a research associate there in 1953. While at the U. of Chicago he worked extensively on mass ratios of binary stars, binary star orbits and the determination of stellar parallaxes. In 1953 Glenn came to the U. S. Naval Observatory (USNO) where he became the Assistant Director of the Time Service Division. His early work at the Naval Observatory was related to the determination of Ephemeris Time (ET) from photographic observations of the Moon with respect to background stars. This work provided a time scale more uniform than that based on the Earth's rotation, which was the internationally accepted time scale at the time. As a result, the International Astronomical Union in 1955 redefined the second to be the second as determined from Ephemeris Time. In June 1955, L. Essen and J.V.L. Parry placed in operation a Cesium beam atomic standard at the National Physical Laboratory in Teddington, England. William Markowitz (1907-1998), the director of the Time Service, and Hall together with Essen and Parry then began the work leading to the determination of the frequency of the Cesium atom in terms of the second of the seasonally corrected time scale determined from the

  6. REARRANGEMENT IN THE B-GENOME FROM DIPLOID PROGENITOR TO WHEAT ALLOPOLYPOLID

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    Salina E.A.

    2012-08-01

    Full Text Available Three key periods that were accompanied by considerable rearrangements in the B genome of wheat and its progenitor can be considered. The first period covers the period from the divergence of diploid Triticum and Aegilops species from their common progenitor (2.5–6 million years ago to formation of the tetraploid T. diccocoides (about 500 thousand years ago. Significant genomic rearrangements in the diploid progenitor of the B genome, Ae. speltoides (SS genome, involved a considerable amplification of repeated DNA sequences, which led to an increase in the number of heterochromatin blocks on chromosomes relative to other diploid Aegilops and Triticum species. Our analysis has demonstrated that during this period the Spelt1 repeats intensively amplified as well as several mobile elements proliferated, in particular, the genome-specific gypsy LTR-retrotransposon Fatima and CACTA DNA-transposon Caspar. The second period in the B-genome evolution was associated with the emergence of tetraploid (BBAA genome and its subsequent evolution. The third most important event leading to the next rearrangement of the B genome took place relatively recently, 7000–9500 years ago, being associated with the emergence of hexaploid wheat with the genomic formula BBAADD. The evolution of the B/S genome involved intergenomic and intragenomic translocations and chromosome inversions. So far, five rearrangements in the B-genome chromosomes of polyploid wheats has been observed and described; the majority of them took place during the formation and evolution of tetraploid species. The mapping of the S-genome chromosomes and comparison with the B-genome chromosome maps have demonstrated that individual rearrangements pre-existed in Ae. speltoides; moreover, Ae. speltoides is polymorphic for these rearrangements.Chromosome 5B is nearly 870 Mbp (5BL = 580 Mbp and 5BS = 290 Mbp and is known to carry important genes controlling the key aspects of wheat biology, in

  7. A comparison of disease burden in rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis.

    Directory of Open Access Journals (Sweden)

    Brigitte Michelsen

    Full Text Available The main objective of this study was to compare disease burden in rheumatoid arthritis (RA, psoriatic arthritis (PsA and axial spondyloarthritis (ax-SpA.In this cross-sectional study, all the RA (1093, PsA (365 and ax-SpA (333 patients who visited the out-patient clinic of the Hospital of Southern Norway Trust during the year 2013 were included; the RA patients all had a RA diagnosis verified by the treating rheumatologist, the PsA patients all fulfilled the ClASsification for Psoriatic ARthritis (CASPAR criteria and the ax-SpA patients all fulfilled the Assessment of SpondyloArthritis international Society (ASAS classification criteria for ax-SpA. Patient-reported health status, demographic variables, medications, and composite scores of disease activity were assessed. The main analyses were performed using General Linear Models adjusted for age, sex and multiple comparisons. Correlation analyses were performed using Spearman's rho.The reported pain, joint pain, patient's global assessment and fatigue were similar in PsA and ax-SpA, but significantly lower in RA. The 28-joint Disease Activity Score (DAS28 (0.3±0.1, p = 0.003, Clinical Disease Activity Index (CDAI (1.0±0.4, p = 0.028 and Routine Assessment of Patient Index Data 3 (RAPID3 (0.4±0.1, p = 0.004 were all significantly higher in PsA vs. RA. RAPID3 showed moderate to high correlation with DAS28 (rho = 0.521, p<0.001 and CDAI (rho = 0.768, p<0.001 in RA and PsA, and with Bath Ankylosing Spondylitis Disease Activity Index (BASDAI (rho = 0.902, p<0.001 and Bath Ankylosing Spondylitis Functional Index (BASFI (0.865, p<0.001 in ax-SpA and PsA.In conclusion, patient- reported outcome measures were similar in our population of PsA and ax-SpA patients, but significantly lower for the RA patients. Composite disease activity measures were lower in RA than in PsA and ax-SpA, but the magnitude of these differences was small and probably not of clinical significance. Our study indicates that

  8. The Danish National Chronic Lymphocytic Leukemia Registry

    Directory of Open Access Journals (Sweden)

    da Cunha-Bang C

    2016-10-01

    Full Text Available Caspar da Cunha-Bang,1 Christian Hartmann Geisler,2 Lisbeth Enggaard,3 Christian Bjørn Poulsen,4 Peter de Nully Brown,2 Henrik Frederiksen,5 Olav Jonas Bergmann,6 Elisa Jacobsen Pulczynski,7 Robert Schou Pedersen,8 Linda Højberg Nielsen,9 Ilse Christiansen,10 Carsten Utoft Niemann2 1Department of Internal Medicine, Roskilde Hospital, Roskilde, Denmark; 2Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; 3Department of Hematology, Herlev Hospital, Herlev, Denmark; 4Department of Hematology, Roskilde Hospital, Roskilde, Denmark; 5Department of Hematology, Odense University Hospital, Odense, Denmark; 6Department of Hematology, Vejle Hospital, Vejle, Denmark; 7Department of Hematology, Aarhus University Hospital, Aarhus, Denmark; 8Department of Hematology, Holstebro Hospital, Holstebro, Denmark; 9Department of Hematology, Esbjerg Hospital, Esbjerg, Denmark; 10Department of Hematology, Aalborg University Hospital, Aalborg, Denmark Aim: In 2008, the Danish National Chronic Lymphocytic Leukemia Registry was founded within the Danish National Hematology Database. The primary aim of the registry is to assure quality of diagnosis and care of patients with chronic lymphocytic leukemia (CLL in Denmark. Secondarily, to evaluate adherence to national guidelines and to provide source data for research purposes. Study population: All patients diagnosed with CLL in Denmark from 2008 onward are included in the registry. Patients are followed in one of nine hematology centers. All centers participate in the registry and are all obliged to collect data. Main variables: Predefined data are collected at the time of diagnosis, and follow-up at the time of significant events: treatment, progression, transplantation, and death. Parameters included in the International Workshop on Chronic Lymphocytic Leukaemia criteria for diagnosis, and for decision on treatment initiation as well as characteristics included in the CLL

  9. A Comparison of Disease Burden in Rheumatoid Arthritis, Psoriatic Arthritis and Axial Spondyloarthritis

    Science.gov (United States)

    Michelsen, Brigitte; Fiane, Ragnhild; Diamantopoulos, Andreas P.; Soldal, Dag Magnar; Hansen, Inger Johanne W.; Sokka, Tuulikki; Kavanaugh, Arthur; Haugeberg, Glenn

    2015-01-01

    Objective The main objective of this study was to compare disease burden in rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (ax-SpA). Methods In this cross-sectional study, all the RA (1093), PsA (365) and ax-SpA (333) patients who visited the out-patient clinic of the Hospital of Southern Norway Trust during the year 2013 were included; the RA patients all had a RA diagnosis verified by the treating rheumatologist, the PsA patients all fulfilled the ClASsification for Psoriatic ARthritis (CASPAR) criteria and the ax-SpA patients all fulfilled the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for ax-SpA. Patient-reported health status, demographic variables, medications, and composite scores of disease activity were assessed. The main analyses were performed using General Linear Models adjusted for age, sex and multiple comparisons. Correlation analyses were performed using Spearman’s rho. Results The reported pain, joint pain, patient’s global assessment and fatigue were similar in PsA and ax-SpA, but significantly lower in RA. The 28-joint Disease Activity Score (DAS28) (0.3±0.1, p = 0.003), Clinical Disease Activity Index (CDAI) (1.0±0.4, p = 0.028) and Routine Assessment of Patient Index Data 3 (RAPID3) (0.4±0.1, p = 0.004) were all significantly higher in PsA vs. RA. RAPID3 showed moderate to high correlation with DAS28 (rho = 0.521, p<0.001) and CDAI (rho = 0.768, p<0.001) in RA and PsA, and with Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (rho = 0.902, p<0.001) and Bath Ankylosing Spondylitis Functional Index (BASFI) (0.865, p<0.001) in ax-SpA and PsA. Conclusion In conclusion, patient- reported outcome measures were similar in our population of PsA and ax-SpA patients, but significantly lower for the RA patients. Composite disease activity measures were lower in RA than in PsA and ax-SpA, but the magnitude of these differences was small and probably not of

  10. Clinical and immunogenetic characteristics of psoriatic arthritis: a single-center experience from South India

    Directory of Open Access Journals (Sweden)

    CB Mithun

    2013-02-01

    Full Text Available AimThe aim of this study was to determine the clinical characteristics and prevalence of HLA B27 in patients with psoriatic arthritis presenting to a tertiary care centre in South India. BackgroundAlthough the prevalence of psoriasis is high in India, there is paucity of data, especially on Ps A. Materials and methodsThis retrospective study included 141 patients satisfying the ClASsification criteria for Ps A (CASPAR. Demographic, clinical, and laboratory data of the patients were collected through personal interviews, clinical examination, appropriate investigations, and analysis of case records. HLA-B27 typing by PCR method was done for all patients. ResultsAmong the 141 patients, 89 subjects were males and 52 were females, and the male to female ratio was 1.7:1. Polyarthritis (n=51, 36.2% was the most common Ps A subtype noted during the study, followed by oligoarthritis (n=48, 34%, spondyloarthropathy (n=29, 20.6%, distal interphalangeal (DIP predominant arthritis (n=25, 7.8%, and arthritis mutilans (n=2, 1.4%. Arthritis preceded skin involvement in 9.2% (n=13 of the cases. Dactylitis was seen in 24.1% (n=34 of the patients. Extra-articular features like enthesitis (n=16, 11.3% and eye involvement (n=1, 0.7% were also observed. Deformities were seen in 32.6% (n=46 of the subjects. The most common type of psoriatic skin lesion noted was psoriasis vulgaris (n=119, 84.4%. Nail involvement was seen in 17.7% (n=25 of the patients and it was observed in all subjects with DIP predominant arthritis (100%. Family history of psoriasis was present in 11.3% (n=16 of the patients. The number of patients positive for HLA B27 was 16 (11.3%. Additionally, the antigen positivity was noted in 35.7% (n=10 of the patients with spondyloarthropathy. ConclusionPs A was more common in males. Polyarthritis and oligoarthritis were the most prevalent subtypes. The prevalence of HLA-B27 in our study population was 11.3% and was found to be strongly associated with

  11. Spondyloarthritis oder Morbus Bechterew: Neue Klassifikation der axialen Spondyloarthritis mit Morbus Bechterew als Endstadium

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    Schirmer M

    2011-01-01

    Full Text Available Mit einer Prävalenz von 0,6–1,9 % ist die axiale Spondyloarthritis (SpA der Sammelbegriff für eine Gruppe von entzündlichen rheumatischen Krankheiten, die vor allem das axiale Skelett und die Insertionsstellen der Sehnen am Knochen (Enthesen betreffen. Je nach Subtyp der SpA besteht eine unterschiedlich starke Assoziation mit dem MHC-I-Antigen HLA-B27. Entsprechend der „Assessment of Spondyloarthritis International Society“ (ASAS wird die SpA anhand der prädominant betroffenen Region in die periphere und die axiale Form unterteilt. Die aktuelle Klassifikation der axialen SpA erfolgt mittels der 2009 veröffentlichten ASAS-Kriterien. Bei Sakroiliitis in der Bildgebung müssen ≥ 1 SpAParameter, bei positivem HLA-B27-Befund ≥ 2 andere SpA-Parameter für die Klassifikation als SpA vorhanden sein. SpA-Parameter sind entzündlicher Rückenschmerz, Arthritis, Familienanamnese, Uveitis anterior, entzündliche Darmerkrankung, Psoriasis, Daktylitis, Enthesitis, gutes Ansprechen auf NSAR und HLA-B27-Positivität. Die Sensitivität dieser Kriterien liegt bei 82,9 %, die Spezifität bei 84,4 %. Für die axiale Beteiligung der Psoriasis arthropathica werden auch die ähnlichen CASPAR-Kriterien verwendet. Für die Klassifikation des Morbus Bechterew werden die 1984 modifizierten New York-Kriterien verwendet, bei denen neben spezifischen klinischen Kriterien radiologisch eine Sacroiliitis Grad 2 oder mehr bilateral oder Grad 3–4 unilateral vorhanden sein muss. Bei schwerem Verlauf kann prinzipiell jede Form der SpA mit einer axialen Beteiligung in einen Morbus Bechterew übergehen. Somit ist der Morbus Bechterew sowohl ein Subtyp der SpA, als auch eine mögliche Spätform anderer Subtypen. Zur Verlaufs- bzw. Therapiekontrolle werden sowohl bei axialer SpA als auch bei Morbus Bechterew spezifische Scores verwendet, um Krankheitsaktivität und Funktionsveränderungen zu dokumentieren (BASFI, BASDAI, ASDAS.

  12. Isolation and sequence analysis of the wheat B genome subtelomeric DNA

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    Huneau Cecile

    2009-09-01

    Full Text Available Abstract Background Telomeric and subtelomeric regions are essential for genome stability and regular chromosome replication. In this work, we have characterized the wheat BAC (bacterial artificial chromosome clones containing Spelt1 and Spelt52 sequences, which belong to the subtelomeric repeats of the B/G genomes of wheats and Aegilops species from the section Sitopsis. Results The BAC library from Triticum aestivum cv. Renan was screened using Spelt1 and Spelt52 as probes. Nine positive clones were isolated; of them, clone 2050O8 was localized mainly to the distal parts of wheat chromosomes by in situ hybridization. The distribution of the other clones indicated the presence of different types of repetitive sequences in BACs. Use of different approaches allowed us to prove that seven of the nine isolated clones belonged to the subtelomeric chromosomal regions. Clone 2050O8 was sequenced and its sequence of 119 737 bp was annotated. It is composed of 33% transposable elements (TEs, 8.2% Spelt52 (namely, the subfamily Spelt52.2 and five non-TE-related genes. DNA transposons are predominant, making up 24.6% of the entire BAC clone, whereas retroelements account for 8.4% of the clone length. The full-length CACTA transposon Caspar covers 11 666 bp, encoding a transposase and CTG-2 proteins, and this transposon accounts for 40% of the DNA transposons. The in situ hybridization data for 2050O8 derived subclones in combination with the BLAST search against wheat mapped ESTs (expressed sequence tags suggest that clone 2050O8 is located in the terminal bin 4BL-10 (0.95-1.0. Additionally, four of the predicted 2050O8 genes showed significant homology to four putative orthologous rice genes in the distal part of rice chromosome 3S and confirm the synteny to wheat 4BL. Conclusion Satellite DNA sequences from the subtelomeric regions of diploid wheat progenitor can be used for selecting the BAC clones from the corresponding regions of hexaploid wheat

  13. PSORIATIC ARTHRITIS: CLASSIFICATION, CLINICAL PRESENTATION, DIAGNOSIS, TREATMENT

    Directory of Open Access Journals (Sweden)

    T. V. Korotaeva

    2014-01-01

    Full Text Available The lecture gives basic information about psoriatic arthritis (PsA, a chronic inflammatory disease of the joints, spine, and enthesises from a group of spondyloarthritis. It describes the epidemiology of the disease and considers current ideas on its pathogenesis and factors influencing the development of PsA in psoriatic patients. The classification and clinical forms of PsA are presented. The major clinical manifestations of the disease are indicated to include peripheral arthritis, enthesitis, dactylitis, and spondylitis. The diagnosis of the disease is noted to be established on the basis of its detected typical clinical and radiological signs, by applying the CASPAR criteria. A dermatologist, rheumatologist, and general practitioner screen PsA, by actively detecting complaints, characteristic clinical and radiological signs of damage to the joints, and/or spine, and/or enthesises and by using screening questionnaires. There are data that patients with PsA are observed to be at higher risk for a number of diseases type 2 diabetes mellitus hypertension, coronary heart disease, obesity, metabolic syndrome, inflammatory bowel diseases, etc. The aim of current pharmacotherapy for PsA is to achieve remission or minimal activity of clinical manifestations of the disease, to delay or prevent its X-ray progression, to increase survival, to improve quality of life in patients, and to reduce the risk of comorbidities. The paper considers groups of medicines used to treat the disease, among other issues, information about biological agents (BA registered in the Russian Federation for the treatment of PsA. Most patients are mentioned to show a good response to this therapy option just 3–6 months after treatment initiation; however, some of them develop primary inefficiency. In this case, switching one BA to another is recommended. Some patients using a BA develop secondary treatment inefficiency, which is firstly due to the appearance of

  14. Mathematics make microbes beautiful, beneficial, and bountiful.

    Science.gov (United States)

    Jungck, John R

    2012-01-01

    Microbiology is a rich area for visualizing the importance of mathematics in terms of designing experiments, data mining, testing hypotheses, and visualizing relationships. Historically, Nobel Prizes have acknowledged the close interplay between mathematics and microbiology in such examples as the fluctuation test and mutation rates using Poisson statistics by Luria and Delbrück and the use of graph theory of polyhedra by Caspar and Klug. More and more contemporary microbiology journals feature mathematical models, computational algorithms and heuristics, and multidimensional visualizations. While revolutions in research have driven these initiatives, a commensurate effort needs to be made to incorporate much more mathematics into the professional preparation of microbiologists. In order not to be daunting to many educators, a Bloom-like "Taxonomy of Quantitative Reasoning" is shared with explicit examples of microbiological activities for engaging students in (a) counting, measuring, calculating using image analysis of bacterial colonies and viral infections on variegated leaves, measurement of fractal dimensions of beautiful colony morphologies, and counting vertices, edges, and faces on viral capsids and using graph theory to understand self assembly; (b) graphing, mapping, ordering by applying linear, exponential, and logistic growth models of public health and sanitation problems, revisiting Snow's epidemiological map of cholera with computational geometry, and using interval graphs to do complementation mapping, deletion mapping, food webs, and microarray heatmaps; (c) problem solving by doing gene mapping and experimental design, and applying Boolean algebra to gene regulation of operons; (d) analysis of the "Bacterial Bonanza" of microbial sequence and genomic data using bioinformatics and phylogenetics; (e) hypothesis testing-again with phylogenetic trees and use of Poisson statistics and the Luria-Delbrück fluctuation test; and (f) modeling of

  15. Elemental and Isotopic Tomography at Single-Atom-Scale in 4.0 and 2.4 Ga Zircons

    Science.gov (United States)

    Valley, J. W.; Reinhard, D. A.; Snoeyenbos, D.; Lawrence, D.; Martin, I.; Kelly, T. F.; Ushikubo, T.; Strickland, A.; Cavosie, A. J.

    2012-12-01

    Atom probe tomography can determine identity (mass/charge ratio) and 3-D position of individual atoms in minerals such as zircon. These data provide unique information for understanding the thermal history and mechanisms of mineral reaction and exchange, including radiation damage. Nine needle-shaped specimens ~100 nm in diameter (at the apex) were sampled from 2 zircons by FIB and analyzed with a local-electrode atom probe (LEAP), CAMECA LEAP 4000X HR. The LEAP uses pulsed-laser heating to field evaporate the tip of a zircon needle and accelerates the ions into a position-sensitive TOF-MS. With due care for complex isobaric interferences (molecules, multiple ionizations) and background correction, it is possible to individually identify up to 10E8 atoms/needle (36% detection efficiency) by mass/charge (MRP ~ 1000@ m/n=16Da) and position (X-Y-Z coordinates on 0.2 nm scale) (Kelly & Larson 2012). The 3-D distribution of Pb and Y differ at atom-scale in the 2 zircons. Zircon #1 (4007 Ma, Jack Hills, W. Australia, Cavosie 2005, Ushikubo et al. 2008, Bouvier et al. 2011) is homogeneous in Pb and Y. In contrast, incompatible elements, including Pb and Y, are concentrated in equant 5-10 nm dia. domains, spaced ~50 nm apart in zircon #2 (2438 Ma, Albion-Raft R-Grouse Ck core complex, Utah, Strickland et al. 2011). U is homogeneously distributed in both zircons. The analyzed domains suffered 4-8 x 10E15 α-decay events/mg due to U and Th decay and yet both zircons yield >97% concordant U-Pb ages by SIMS, suggesting annealing of radiation damage during the life of the zircons. The 207-Pb/206-Pb ratios for these nm-scale domains, as measured by LEAP, average 0.17 for the 2.4 Ga Zrc2 (3 needles) and 0.43 for the 4.0 Ga Zrc1 (5 needles). These ratios are less precise (±40% 2σ) due to ultra-small sample size, but are in excellent agreement with values measured by SIMS, 0.1684 and 0.4269, respectively. Thus Pb in both zircons is radiogenic. The Pb-Y-rich domains and lack of

  16. Relation of gene expression to anthocyanins metabolism in strawberry fruits%草莓果实基因表达与花色苷代谢的关系

    Institute of Scientific and Technical Information of China (English)

    肖敏; 汪佳易; 李皓; 罗赟; 林晓; 陈宗玲; 王红清

    2013-01-01

    The aim of this research is to probe further into the anthocyanins metabolism and functions of enzymes involved in the synthesis of anthocyanins in strawberry fruits. The coding sequences of three genes encoding DFR.ANS and LAR were cloned from 'Albion' (Fragaria x ananassa ) strawberry fruits by RT-PCR. The predicted protein sequences shared 99%~100% homology to those of 'Queen Elisa' and ' Korona' ( Fragaria x ananassa) strawberry published in NCBI.Semiquantitative RT-PCR showed that DFR had three transcript level peaks at fruitlet stage, white stage and red stage, respectively, with the highest at red stage. The transcript level of ANS increased rapidly from white stage,reaching the highest at red stage. The transcript level of LAR showed a decreased trend with the highest at fruitlet stage. During the development of strawberry fruits, the transcript level of DFR peaks at fruitlet and red stages correlated with the concentration of flavan-3-nols and anthocyanins. The LAR and ANS were closely correlative with the synthesis of anthocyanins and flavan-3-ols,respectively.%为进一步探究草莓果实花色苷合成过程中各个酶的作用,明确草莓果实花色苷的代谢机制,以‘阿尔比’草莓(Fragaria×ananassa‘Albion’)为试材,利用RT-PCR从草莓果实中克隆到DFR、ANS和LAR基因的编码序列,对预测的氨基酸序列进行分析,结果表明:各基因与NCBI(美国国立生物技术信息中心)上已有的草莓品种‘Queen Elisa’及‘Korona’(Fragaria×ananassa)所对应基因的同源性高达99%~100%.半定量RT-PCR分析表明,DFR基因依次在幼果期、白熟期和红熟期出现了3个表达峰值,其中红熟期最大;ANS基因的表达量在白熟期后迅速增加,红熟期达最大值;LAR基因的最大表达量出现在幼果期,后呈降低趋势.草莓果实发育过程中,DFR基因在幼果期和红熟期的表达峰值分别与黄烷-3-醇类和花色苷的合成峰值相一致,ANS及LAR分别

  17. 70例关节病性银屑病患者临床特征研究%Clinical features of 70 cases of psoriatic arthritis

    Institute of Scientific and Technical Information of China (English)

    赵伟; 于倩; 丁杨峰; 谢韶琼; 史玉玲

    2016-01-01

    Objective To investigate the prevalence of psoriatic arthritis (PsA) in patients with psoriasis and its clinical features.Methods A cross-sectional study was conducted among patients diagnosed with psoriasis from January 2014 to January 2015.Through a questionnaire survey,the diagnosis of PsA was confirmed according to the Classification Criteria for Psoriatic Arthritis (CASPAR) in patients with suspected PsA.Clinical data were collected from patients with newly and previously diagnosed PsA.Statistical analysis was carried out by t test for two-group comparisons,one-way analysis of variance (ANOVA) for multi-group comparisons,and chi-square test for comparisons of rates.All the statistical tests were two-sided.Results Totally,1 062 outpatients with psoriasis were enrolled into this study,and 125 were suspected to have PsA.According to the CASPAR,70 (6.59%) patients were finally diagnosed with PsA,with the ratio of male to female being 2.1 ∶ 1,and 45 of them (64.29%) were newly diagnosed.Psoriasis vulgaris lesions were observed in 50 (71.43%) patients with PsA,and were the most common type of skin lesions in patients with PsA.There were 5 clinical types of PsA in these patients,including asymmetrical oligoarthritis (23 cases,32.86%),symmetric polyarthritis (19 cases,27.14%),distal interphalangeal predominant arthritis (10 cases,14.29%),vertebral or sacroiliac arthropathy (7 cases,10.00%),and arthritis mutilans (11 cases,15.71%),with some overlap among these clinical types.As relatively distinctive manifestations of PsA,dactylitis and enthesitis were observed in 14 (20.00%) and 8 cases (11.43%) respectively.In addition,43 (61.43%) cases had nail involvements.Conclusion To master clinical features of PsA and to diagnose it early are of great significance for long-term prognosis of PsA patients.%目的 探讨关节病性银屑病(PsA)在银屑病中的比例及其临床特征.方法 对2014年1月至2015年1月诊断为银屑病的患者进行

  18. Comparative characterization of the data of magnetic resonance imaging, X-ray and clinical studies of the hand and foot joints in patients with early psoriatic arthritis

    Directory of Open Access Journals (Sweden)

    Svetlana Olegovna Krasnenko

    2013-01-01

    Full Text Available The clinical manifestations of psoriatic arthritis (PsA at its early stage may be inadequately informative. In this connection, radiological techniques, such as magnetic resonance imaging (MRI and X-ray study of peripheral joints, in addition to clinical examination are of paramount importance in the diagnosis of early PsA. Objective: To compare the data of clinical examination and various imaging methods (MRI and X-ray of the hand and foot joints in early peripheral PsA. Subjects and methods. The trial included 45 patients (14 men and 31 women; mean age 42.08±13.7 years; median PsA duration 1 year [range 0.55 to 2] with early peripheral PsA without previous therapy with disease-modifying antirheumatic drugs (DMARDs, who met the CASPAR criteria (2006. A standard clinical examination was performed and the activity of peripheral arthritis and the presence of enthesitis and dactylitis were determined in the patients. Not later than 2 days after the clinical examination, a standard X-ray examination of the hands and feet in the direct projection and MRI of the same areas were made. Results. When included into the study, the entire group of patients was found to have a moderate PsA by DAS; its median was 3.12 [2.21 to 3.89]. Cutaneous PsA was noted in 40 patients; 5 persons had a family history of PsA; one female patient had ungual PsA only. In the study group, the clinical signs of enthesitis in the tendon attachments at different sites were revealed in 33 (75.3% patients. Dactylitis was found in 34 (75% patients. The clinical examination showed inflammatory changes in the hand and foot joints in 36 (80% and 38 (84% patients, respectively; while MRT revealed them in 31 (69% and 32 (71% patients. Hand MRI displayed arthritis of the proximal interpha-langeal (PIP, metacarpophalangeal (MCP, and distal interphalangeal (DIP joints in 27 (87%, 21 (68%, and 12 (40% of the 31 patients, respectively. Foot MRI exhibited MCP, PIP, and DIP joint arthritis in

  19. Geysers Unit 18

    Energy Technology Data Exchange (ETDEWEB)

    Finney, John P.

    1980-12-01

    The geothermal user's viewpoint in this case is somewhat unique. San Diego Gas & Electric Company, by virtue of its activity in geothermal exploration and development since 1972, is in a position to be considered not only a user of geothermal, but a producer as well through the activities of its wholly-owned subsidiary, New Albion Resources Co. As the Supervisor of Fuel Development of SDG&E and the General Manager of NARCO, I can speak from experience on both sides of the negotiating table. I have given advice from the user's point of view to SDG&E's fuel acquisitions people as they labored to negotiate a contract to buy from a geothermal producer of hot water. As General Manager of NARCO, I am in the position of developing geothermal resources and negotiating contracts to sell some of NARCO's heat to third parties. So much for the introduction--How does a utility, such as SDG&E, view risk in today's business climate? The answer to that question is very simple. SDG&E has an allowed rate of return of 10.59%. This is based upon 48% debt, having an imbedded interest cost of 8.1%; 14% preferred stock, at a cost of 8.2% and 42% equity. Out rates are supposed to return 14-112% on this equity. Let me put these numbers in perspective. In early March SDG&E sold $50 million of mortgage bonds which bear an interest rate of 16%. In mid-March we sold 2-112 million shares of common stock for $11.50 per share. The current dividend of $1.52 will yield 13.2% and those dividends are paid after taxes. When money borrowed to build a project costs more than you can earn on the project, there is no incentive to build that project and certainly no incentive to take any risk associated with the project. How does SDG&E view risks? Simple--don't take any risks which can be avoided. Is this attitude likely to change? My forecast is, there is no change in sight. Does this take SDG&E out of contention as a possible market for producers of geothermal energy? Not

  20. [Man and his fellow-creatures under ethical aspects

    Science.gov (United States)

    Teutsch

    1999-01-01

    Preliminary remarks Preceding the detailed literary review, here a few events, topics and publications for the busy reader including * The decision of the Bundesverfassungsgericht (Federal Constitutional Court) to declare unconstitutional and invalid chicken owner ordinances permitting caging * The decision of the German parliament to declare animal protection a national goal * Publication of a number of books which are likely to influence discussions for years to come since they bring to a close developments having emerged over an extended period of time. Without claiming to be exhaustive the following should be mentioned: Marc Bekoff and Carron A. Meany, ed.: "Encyclopedia of animal rights and animal welfare", an extensive work being reviewed by Peter Thornton in chapter 3.6 of this report. For the first time, animal protection of the Anglo-American tradition is being summarised, in theory as well as in practice, and, on high standards: "The list of contributors reads like a Who"s Who of experts in their chosen fields and includes philosophers such as Peter Singer, Tom Regan, Tom Beauchamp and Bernard Rollin and welfare scientists such as Don Broom, David Fraser, Temple Grandin. Others involved in examining the role of animals in society and our relationship with them, such as Andrew Linzey, Richard Ryder, James Serpell and David Morton (to name just a few), have also provided entries" (Peter Thornton). The comprehensive monograph by Johannes Caspar: "Tierschutz im Recht der modernen Industriegesellschaft. Eine rechtliche Neukonstruktion auf philosophischer und historischer Grundlage" (Animal Protection in the Law of modern industrial Society. A new legal Construct on a philosophical and historical Base) represents an extensive critical incorporation of animal protection in Germany under legal and ethical aspects including a detailed rendering of the actual treatment of animals. The term "critical incorporation" was used on purpose since never before was cruelty

  1. Artificial Cervical Disc Arthroplasty (ACDA): tips and tricks

    Science.gov (United States)

    Khadivi, Masoud; Rahimi Movaghar, Vafa; Abdollahzade, Sina

    2012-01-01

    presented with cervical discopathy who had myelopathy or radiculopathy and failed conservative management, undergoing cervical disc arthroplasty by ACDA were included, consecutively. Patients were followed for at least 2 years. Exclusion criteria was age greater than 60 years, non compliance with the study protocol, osteoporosis, infection, congenital or post traumatic deformity, malignancy metabolic bone disease, and narrow cervical canal (less than 12 mm). Heterotopic ossification and adjacent segment degenerative changes were assessed at 2 years follow up by means of neutral and dynamic xrays and CT/MRI if clinically indicated. Neck and upper extremity pain were assessed before the procedure and in the first post-operative visit and 3 months later by means of visual analogue scale. A standard approach was performed to the anterior cervical spine. Patients were positioned supine while holding neck in neutral position. A combination of sharp and blunt dissection was performed to expose longus coli musculature and anterior cervical vertebrae. Trachea and esophagus were retracted medially and carotid artery and jugular vein laterally. After a thorough discectomy, the intersomatic space is distracted in a parallel way by a vertebral distracter. Followed by Caspar distractor is applied to provide a working channel into posterior disc space. In this stage, any remnant disc materials as well as osteophytes are removed and foraminal decompression is done. Posterior longitudinal ligament (PLL) opening and removal, although discouraged by some, is done next. In order to define the size of the prosthesis, multiple trials are tested. It is important not to exceed the height of the healthy adjacent disc to avoid facet joint overdistraction. An specific insertor is applied to plant the prosthesis in disc space. Control X-rays are advised to check the precise positioning of the implant. Results: one hundred-fifty three patients including 87 females and 66 males were included. The mean

  2. Book Review: Beitraege zur Astronomiegeschichte, Band 5 (Acta Historica Astronomiae Vol. 15)

    Science.gov (United States)

    Duerbeck, H. W.; Dick, W. R.; Hamel, J.

    2002-12-01

    The 15th volume of the Acta Historica Astronomiae is at the same time the fifth collection of essays on the history of astronomy (Beitraege zur Astronomiegeschichte, Band 5), edited by the historians of astronomy W.R. Dick (Potsdam) and J. Hamel (Berlin). Besides a few short notices and book reviews, the book contains 11 major articles, which deal with astronomical topics covering the time from the 16th to the 20th centuries. The first article, on the analysis and interpretation of historical horoscopes as a source of the history of science, is based on the inaugural lecture of its author, Guenther Oestmann. After a general introduction, which deals with the principles of horoscope making, the author discusses the horoscope of Count Heinrich Ranzau (1526-1598), the Danish governor of Schleswig-Holstein, who was a friend of Tycho Brahe. Oestmann shows that the astronomical-mathematical basis of such a horoscope can be reconstructed and interpreted. However, it is hardly possible to gain an insight in the process how the interpretation of a horoscope was done in detail. The second and third articles, by Franz Daxecker, deal with Athanasius Kircher and Christoph Scheiner, two catholic astronomers of the 17th century. Kircher's Organum Mathematicum is a calculating device that can be used in the fields of arithmetic, geometry, chronology, astronomy, astrology and others. The author provides extracts of the description of the Organum taken from a book by Caspar Schott, which deal with chronology and astronomy. A photograph of the Organum indicates that this tool consists of a set of tables glued on wooden or cardboard, but details of its contents and applications remain pretty obscure for the reader - a few elaborated examples would have been helpful. The second paper deals with the life of Christoph Scheiner SJ, the co-discoverer of sunspots (next to Galileo), after leaving Rome in 1633 - the year of the Galileo trial. Scheiner spent his later years in the Austrian and