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Sample records for lynn ts maury

  1. Maury Documentation

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Supporting documentation for the Maury Collection of marine observations. Includes explanations from Maury himself, as well as guides and descriptions by the U.S....

  2. The Maury Project

    Science.gov (United States)

    2016-06-07

    Weinbeck (2006). “The Maury Project, and Online Ocean Studies: AMS Initiatives in Ocean Science Education ”, Marine Science Technology Journal, 39(4...The Maury Project Ira W. Geer Education Program American Meteorological Society 1120 G Street, N.W., Suite 800 Washington, DC 20005 Tel: 202...workshop. IMPACT /APPLICATIONS Maury Project summer workshop participants are committed to organizing and offering a minimum of two single-topic

  3. Maury Journals - German Vessels

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — German vessels observations, after the 1853 Brussels Conference that set International Maritime Standards, modeled after Maury Marine Standard Observations.

  4. Maury Journals - US Vessels

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — U.S. vessels observations, after the 1853 Brussels Conference that set International Maritime Standards, modeled after Maury Marine Standard Observations.

  5. Zona Lynn Unveiled in CBD

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    On September 29,many fashion industry elites gathered at the Beijing Fortune Plaza at the heart of the Beijing Central Business District(CBD) for a press conference on Zona Lynn,a high-end tailor-made clothing brand.Amid beautiful flowers and applauses,

  6. Lynne Cherry's World: A Celebration of Nature.

    Science.gov (United States)

    Winarski, Diana L.

    1995-01-01

    Profiles Lynne Cherry, author-illustrator whose books convey her interest in environmentalism and preserving natural resources. Describes her career, process of illustrating several recent books, and founding of the Center for Children's Environmental Literature in 1992. (TM)

  7. Mauri pärlid Soome lahe kaldal

    Index Scriptorium Estoniae

    2007-01-01

    Narva-Jõesuu puitpitsiga suvilatest - Kreenholmi manufaktuuri juhi Robert Kolbe mauri stiilis villa, mis põles 2006. a. suvel ja Pantelejevi villa, mille puitpitsid olid Karjala-Vene rahvuslikus stiilis. Aprillis avatakse Narva-Jõesuu puitarhitektuurist fotonäitus Jõhvi Kontserdimajas

  8. 76 FR 58105 - Regulated Navigation Area; Saugus River, Lynn, MA

    Science.gov (United States)

    2011-09-20

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA11 Regulated Navigation Area; Saugus River, Lynn, MA AGENCY... River in Lynn, MA. Establishing this temporary rule will allow the necessary stabilization work to be... on the Energy Systems Pipeline Bridge on the Saugus River in Lynn, MA. The regulated area...

  9. Obituary: Lynne Karen Deutsch, 1954-2004

    Science.gov (United States)

    Sprague, Ann L.

    2004-12-01

    It is with deep sadness and regret that we note the passing of our dear friend and colleague Prof. Lynne K. Deutsch. Lynne died on 2 April 2004 after a protracted illness and lengthy battle with complications caused by the blood disease Polycythaemia Vera. Lynne was born in Chicago on 26 November 1956 to Victor and Ailsa Deutsch. She lived with her family in the town of Morton Grove, IL until she was 8 years old, when they moved to Beverly Hills, CA. She was an outgoing child who played basketball and excelled in her studies. She graduated from Beverly Hills High School at the age of 16 after completing all high school requirements in only three years. Lynne had a beautiful singing voice, and was in the chorus in high school and college. Lynne earned her first bachelor's degree in philosophy from the University of California at Berkeley in 1977. She then returned to Berkeley and received a second bachelor's degree, this time in physics, in 1981. She was a graduate student and teaching assistant at MIT and earned an MS in physics from MIT in 1983. Lynne then attended the astronomy graduate program at Harvard University, where she earned her MA in 1985 and PhD in 1990. During her degree studies she began crafting mid-infrared instrumentation. These instruments were destined to be used by a host of eager observers to discover, identify, and study many emissions from the Solar System, and galactic and extragalactic sources. Lynne was a National Research Council Post-doctoral Fellow at NASA Ames Research Center from 1990 - 1992, where she played an important role in the development of the Smithsonian Astrophysical Observatory/University of Arizona Mid-Infrared Array Camera (MIRAC), a well-known and much sought after instrument frequently used in studies of Mercury, Jupiter, the Moon, planetary nebulae, star formation regions, galactic center, young stellar objects, and extragalactic objects. After leaving NASA Ames Research Center, Lynne taught for several years (1993

  10. Maury Nussbaum reappointed as Hal G. Prillaman Professor Fellow in Industrial and Systems Engineering

    OpenAIRE

    Owczarski, Mark

    2010-01-01

    Maury Nussbaum, professor of industrial and systems engineering in the College of Engineering at Virginia Tech, has been reappointed as the Hal G. Prillaman Professor Fellow in Industrial and Systems Engineering by the Virginia Tech Board of Visitors.

  11. Symposium on Highlights from 14 years of LEAR Physics : "AD Project" by S. Maury

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields: S. Maury "AD Project"

  12. AFSC/ABL: Lynn Canal Echo-Integrated Trawl Surveys, 2001-2004

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The acoustic trawl database for Lynn Canals echo-trawl survey was conducted from 2001 to 2004 throughout southern Lynn Canal in southeast Alaska. Acoustic surveys...

  13. AFSC/ABL: Lynn Canal Overwinter Acoustic Survey, 2004-2005

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The acoustic trawl database for Lynn Canals echo-trawl survey was conducted from 2001 to 2004 throughout southern Lynn Canal in southeast Alaska. Acoustic surveys...

  14. Repair of acute Achilles tendon ruptures using Lynn method

    Directory of Open Access Journals (Sweden)

    Tolga Tolunay

    2013-09-01

    Full Text Available Objectives: Efficiency assessment of Lynn method onopen primary repair of acute Achilles tendon ruptures.Methods: Data were evaluated from 19 patients whotreated with the Lynne method due to acute Achilles tendonrupture. Average follow-up length was 12.3 months(range 8-15 months. Dominant side was the right sideby all patients and all patients were males. Plantaris tendonaugmentation was applied after end-to-end repair bymodified Kessler suture technique.Results: The mean postoperative AOFAS score (TheAmerican Orthopaedic Foot and Ankle Society hindfootclinical outcome scores was 93.5 (range 82-100. Theaverage of Achilles tendon postoperative assessmentscore, as developed by Thermann and colleagues, was93.3. Both assessment scores were between 90-100 andwere evaluated as very good. None of the patients developedpost-operative wound infection. The Thompson testwas negative on all patients and bilateral motor strengthwas 5/5.Conclusion: Lynn method, especially in young and activepatients with acute Achilles tendon rupture is a methodthat should be considered in treatment protocols.Key words: Achilles tendon, Lynn method, AOFAS score

  15. Tourette Syndrome (TS): Treatments

    Science.gov (United States)

    ... Articles & Key Findings Free Materials Info For Families Bullying Info for Health Professionals Info for Education Professionals ... Tics (CBIT) CBIT is a new, evidence-based type of behavioral therapy for TS and chronic tic ...

  16. Reality versus fantasy: reply to Lynn et al. (2014).

    Science.gov (United States)

    Dalenberg, Constance J; Brand, Bethany L; Loewenstein, Richard J; Gleaves, David H; Dorahy, Martin J; Cardeña, Etzel; Frewen, Paul A; Carlson, Eve B; Spiegel, David

    2014-05-01

    We respond to Lynn et al.'s (2014) comments on our review (Dalenberg et al., 2012) demonstrating the superiority of the trauma model (TM) over the fantasy model (FM) in explaining the trauma-dissociation relationship. Lynn et al. conceded that our meta-analytic results support the TM hypothesis that trauma exposure is a causal risk factor for the development of dissociation. Although Lynn et al. suggested that our meta-analyses were selective, we respond that each omitted study failed to meet inclusion criteria; our meta-analyses thus reflect a balanced view of the predominant trauma-dissociation findings. In contrast, Lynn et al. were hypercritical of studies that supported the TM while ignoring methodological problems in studies presented as supportive of the FM. We clarify Lynn et al.'s misunderstandings of the TM and demonstrate consistent superiority in prediction of time course of dissociative symptoms, response to psychotherapy of dissociative patients, and pattern of relationships of trauma to dissociation. We defend our decision not to include studies using the Dissociative Experiences Scale-Comparison, a rarely used revision of the Dissociative Experiences Scale that shares less than 10% of the variance with the original scale. We highlight several areas of agreement: (a) Trauma plays a complex role in dissociation, involving indirect and direct paths; (b) dissociation-suggestibility relationships are small; and (c) controls and measurement issues should be addressed in future suggestibility and dissociation research. Considering the lack of evidence that dissociative individuals simply fantasize trauma, future researchers should examine more complex models of trauma and valid measures of dissociation.

  17. Mentor-Mentee Relationship in an Educational Leadership Doctoral Program at Lynn University

    Science.gov (United States)

    Reedy, Katherine; Taylor-Dunlop, Korynne

    2015-01-01

    Lynn University embraces the Carnegie Project on the Education Doctorate (CPED) initiative, signature pedagogies and the development of scholarly practitioners. In response to the evolution of educational leadership, Lynn University values the need for doctoral candidates to understand the group process and to be able to work within a diverse…

  18. Another Failure to Replicate Lynn's Estimate of the Average IQ of Sub-Saharan Africans

    Science.gov (United States)

    Wicherts, Jelte M.; Dolan, Conor V.; Carlson, Jerry S.; van der Maas, Han L. J.

    2010-01-01

    In his comment on our literature review of data on the performance of sub-Saharan Africans on Raven's Progressive Matrices, Lynn (this issue) criticized our selection of samples of primary and secondary school students. On the basis of the samples he deemed representative, Lynn concluded that the average IQ of sub-Saharan Africans stands at 67…

  19. 33 CFR 110.27 - Lynn Harbor in Broad Sound, Mass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lynn Harbor in Broad Sound, Mass. 110.27 Section 110.27 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.27 Lynn Harbor in Broad Sound, Mass. North...

  20. Saugus River and Tributaries Flood Damage Reduction Study: Lynn, Malden, Revere and Saugus, Massachusetts. Section 1. Feasibility Report.

    Science.gov (United States)

    1989-12-01

    Flood Damage Reduction Study: Lynn, Malden, Revere, and Saugus, MassachusetLs: Section I Feasibility Report 12. PERSONAL AUTHOR(S) Robert Hunt - Project...employ- Problem Identification 20 ment in the communities is characterized by personal services, rather than higher paying professional services. Many...Formulation 50 LYNN BEACH LYNN DIKES AND gLYNN HARBOR -GE FL~TIA 1w IVER FODAE U -~z~POINT OF EAST SAUGUSWALREEMN PROTECT STORAGE PONDING AREA SAUGUS91

  1. 76 FR 60489 - Lynn E. Stevenson; Notice of Termination of License by Implied Surrender and Soliciting Comments...

    Science.gov (United States)

    2011-09-29

    ... Energy Regulatory Commission Lynn E. Stevenson; Notice of Termination of License by Implied Surrender and... No.: 8866-009. c. Date Initiated: September 23, 2011 (notice date). d. Licensee: Lynn E. Stevenson. e... Lynn E. Stevenson.\\1\\ The project has not operated since a downstream landslide in 1993 and has...

  2. Effects of oilfield brinewater discharges on Western sandpipers (Calidris mauri) in Nueces Bay, Texas

    Science.gov (United States)

    Capizzi, J.L.; King, K.A.; Melancon, M.J.; Rattner, B.A.; LeCaptain, L.

    1993-01-01

    Western sandpipers (Calidris mauri) were studied at an oilfield brinewater discharge site near Corpus Christi, Texas, and at a reference site near Galveston, Texas. Morphological indices, hepatic monooxygenase activities, and contaminant burdens were quantified to evaluate exposure and effects. Pooled stomach contents of birds collected at the discharge site contained higher concentrations of petroleum hydrocarbons than the reference site. Total pristane concentration, and the ratio of pristane:n-heptadecane in sandpiper carcasses were significantly greater at the oil discharge site, indicative of chronic exposure. Concentrations of other organic contaminants (petroleum aromatic hydrocarbons, polychlorinated biphenyls and organochlorine pesticides and metabolites) in carcasses at both study sites were relatively low. Neither body weight, bill length or hepatic monooxygenase activities differed between sites, although liver weight and liver weight:body weight ratio were significantly lower at the discharge site. These data suggest that oilfield brinewater discharges have only limited toxicity to sandpipers wintering near the site.

  3. Saugus River and Tributaries, Lynn Malden, Revere and Saugus, Massachusetts. Flood Damage Reduction. Volume 6. Appendix I. Planning Correspondence: Lynn, Malden, Revere, Saugus, Interest Groups, and News Articles

    Science.gov (United States)

    1989-06-01

    TUMORS . LOBSTER HAD HIGH LEVELS OF CANCER CAUSING PCB"S AND CLAMS SHOWED HIGH LEVELS OF VIRUSES AND DISEASES. THIS IS FACT IN BOSTON HARBOR AND QUINCY BAY...te corp IsI ’paring plans far I. An Is million Roughans Peb VIATTL. - Par I 1-9 DAILY EVENING ITEM. Lynn, Mama .. Friday, May 16, 1986 Flood control

  4. Lynn White Jr. and the greening-of-religion hypothesis.

    Science.gov (United States)

    Taylor, Bron; Van Wieren, Gretel; Zaleha, Bernard Daley

    2016-10-01

    Lynn White Jr.'s "The Historical Roots of Our Ecologic Crisis," which was published in Science in 1967, has played a critical role in precipitating interdisciplinary environmental studies. Although White advances a multifaceted argument, most respondents focus on his claim that the Judeo-Christian tradition, especially Christianity, has promoted anthropocentric attitudes and environmentally destructive behaviors. Decades later, some scholars argue contrarily that Christianity in particular and the world's predominant religions in general are becoming more environmentally friendly, known as the greening-of-religion hypothesis. To test these claims, we conducted a comprehensive review of over 700 articles-historical, qualitative, and quantitative-that are pertinent to them. Although definitive conclusions are difficult, we identified many themes and dynamics that hinder environmental understanding and mobilization, including conservative theological orientations and beliefs about the role of divine agency in preventing or promoting natural events, whether the religion is an Abrahamic tradition or originated in Asia. On balance, we found the thrust of White's thesis is supported, whereas the greening-of-religion hypothesis is not. We also found that indigenous traditions often foster proenvironmental perceptions. This finding suggests that indigenous traditions may be more likely to be proenvironmental than other religious systems and that some nature-based cosmologies and value systems function similarly. Although we conclude White's thesis and subsequent claims are largely born out, additional research is needed to better understand under what circumstances and communication strategies religious or other individuals and groups may be more effectively mobilized to respond to contemporary environmental challenges. © 2016 Society for Conservation Biology.

  5. Chemical composition and antioxidant activity of aerial parts of Ferula longipes Coss. ex Bonnier and Maury.

    Science.gov (United States)

    Bouratoua, Aicha; Khalfallah, Assia; Bensouici, Chawki; Kabouche, Zahia; Alabdul Magid, Abdulmagid; Harakat, Dominique; Voutquenne-Nazabadioko, Laurence; Kabouche, Ahmed

    2017-07-16

    This is the first study on the phytochemistry and antioxidant activity of Ferula longipes Coss. ex Bonnier and Maury (Apiaceae). A new flavonoid quercetin-3-O-α-L-rhamnopyranoside-7-O-ß-D-[2-O-caffeoyl]-glucopyranoside (1), along with 10 known compounds kaempferol-3-O-α-L-rhamnopyranoside (2), quercetin-3-O-α-L-rhamnopyranoside (3), kaempferol-3-O-ß-D-glucopyranoside-7-O-α-L-rhamnopyranoside (4), isorhamnetin-3-O-α-L-rhamnopyranoside-7-O-ß-D-glucopyranoside (5), quercetin-3-O-α-L-rhamnopyranoside-7-O-ß-D-glucopyranoside (6), isorhamnetin-3,7-di-O-β-D-glucopyranoside (7), apigenin (8), apigenin-7-O-ß-D-glucopyranoside (9), 3,5-dicaffeoylquinic acid (10), deltoin (11) were isolated from the aerial parts of Ferula longipes Coss. Structures elucidation was performed by comprehensive 1D and 2D NMR analyses, mass spectrometry and by comparison with literature data. The compounds 1, 3, 4, 6, 7 and 10 were evaluated for their antioxidant activity, compound 1 exhibited the best antiradical activity potential and showed IC50 and A0.5 values 5.70, 7.25, 5.00, and 2.63 μg/mL towards DPPH free radical-scavenging, ABTS, CUPRAC, and reducing power assays, respectively compared with BHA, BHT and ascorbic acid which were used as positive controls.

  6. 77 FR 32625 - William J. Stevenson, Estate of Lynn E. Stevenson, Black Canyon Bliss, LLC; Notice of Application...

    Science.gov (United States)

    2012-06-01

    ... Energy Regulatory Commission William J. Stevenson, Estate of Lynn E. Stevenson, Black Canyon Bliss, LLC... 23, 2012, William J. Stevenson, Estate of Lynn E. Stevenson (transferor) and Black Canyon Bliss, LLC (transferee) filed an application for the transfer of license for the Stevenson No. 2 Project (FERC No....

  7. 76 FR 43997 - N. Stanley Standal and Loretta M. Standal; Lynn E. Stevenson; Notice of Change in Docket Numbers

    Science.gov (United States)

    2011-07-22

    .... Stanley Standal and Loretta M. Standal; Lynn E. Stevenson; Notice of Change in Docket Numbers 1. On March 18, 1986, the Commission issued two licenses to the Lynn E. Stevenson, one for Project No. 1, FERC... (1986). \\2\\ 34 FERC ] 62,530 (1986). 2. Several years later, Mr. Stevenson died and, on March 18,...

  8. Redescription of Iberoiulus cavernicola Ceuca, 1967, and the relationships of the genus Iberoiulus Mauriès, 1985 (Diplopoda, Julida, Blaniulidae)

    DEFF Research Database (Denmark)

    Enghoff, Henrik; P. S. Reboleira, Ana Sofia

    2014-01-01

    The Iberian blaniulid millipede Iberoiulus cavernicola Ceuca, 1967, is redescribed based on abundant new material collected in a cave in Villaluenga del Rosario, Cádiz, Spain. The relationships of the genus Iberoiulus Mauriès, 1985, to other blaniulid genera are discussed.......The Iberian blaniulid millipede Iberoiulus cavernicola Ceuca, 1967, is redescribed based on abundant new material collected in a cave in Villaluenga del Rosario, Cádiz, Spain. The relationships of the genus Iberoiulus Mauriès, 1985, to other blaniulid genera are discussed....

  9. 76 FR 21330 - Lynn Canal/Icy Straits Resource Advisory Committee

    Science.gov (United States)

    2011-04-15

    ...The Lynn Canal/Icy Straits Resource Advisory Committee will meet in Juneau, Alaska, April 25, 2011. The purpose of this meeting is to orient the new appointees as to the Secure Rural Schools and Community Self-Determination Act of 2008, provide operational guidelines, discuss and adopt specific bylaws for the RAC, and elect a RAC...

  10. 78 FR 18849 - Drawbridge Operation Regulations; Saugus River, Saugus and Lynn, MA

    Science.gov (United States)

    2013-03-28

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Saugus River, Saugus and Lynn, MA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from regulations. SUMMARY: The...

  11. 77 FR 42433 - Drawbridge Operation Regulations; Saugus River, Lynn and Revere, MA

    Science.gov (United States)

    2012-07-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Saugus River, Lynn and Revere, MA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from regulations. SUMMARY: The...

  12. 76 FR 73510 - Drawbridge Operation Regulations; Saugus River, Lynn and Revere, MA

    Science.gov (United States)

    2011-11-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Saugus River, Lynn and Revere, MA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from regulations. SUMMARY: The...

  13. 78 FR 9588 - Drawbridge Operation Regulations; Saugus River, Lynn and Revere, MA

    Science.gov (United States)

    2013-02-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Saugus River, Lynn and Revere, MA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from regulation. SUMMARY: The U.S....

  14. An Adolescent's Best Friend: The Roles of Animals in Lynn Hall's Fiction.

    Science.gov (United States)

    Brown, Joanne

    1994-01-01

    Discusses the way Lynn Hall uses animals in her novels. Shows how her use of animals varies from background to the focus of the story, often as central object of the heroine's affection. Analyzes Hall's animal novels as archetypically romantic in pattern. (HB)

  15. An Interview Forum on Interlibrary Loan/Document Delivery with Lynn Wiley and Tom Delaney

    Science.gov (United States)

    Hasty, Douglas F.

    2003-01-01

    The Virginia Boucher-OCLC Distinguished ILL Librarian Award is the most prestigious commendation given to practitioners in the field. The following questions about ILL were posed to the two most recent recipients of the Boucher Award: Tom Delaney (2002), Coordinator of Interlibrary Loan Services at Colorado State University and Lynn Wiley (2001),…

  16. Intertidal biofilm distribution underpins differential tide-following behavior of two sandpiper species (Calidris mauri and Calidris alpina) during northward migration

    NARCIS (Netherlands)

    Jimenez, A.; Elner, R.W.; Favaro, C.; Rickards, K.; Ydenberg, R.C.

    2015-01-01

    The discovery that some shorebird species graze heavily on biofilm adds importance to elucidating coastal processes controlling biofilm, as well as impetus to better understand patterns of shorebird use of intertidal flats. Western sandpipers (Calidris mauri) and dunlin (Calidris alpina) stopover in

  17. 77 FR 55452 - Lynn Canal-Icy Strait Resource Advisory Committee

    Science.gov (United States)

    2012-09-10

    ...The Lynn Canal-Icy Strait Resource Advisory Committee (LC-IS RAC) will meet in Juneau, AK. The committee is authorized under the Secure Rural Schools and Community Self-Determination Act (Pub. L. 112- 141) (the Act) and operates in compliance with the Federal Advisory Committee Act. The purpose of the committee is to improve collaborative relationships and to provide advice and recommendations......

  18. Spectroscopic Classification of ASASSN-15ts

    Science.gov (United States)

    Prieto, J. L.

    2015-12-01

    We obtained an optical spectrum of ASASSN-15ts (ATel #8380) on UT 2015 December 8.1 with GMOS mounted on the Gemini South telescope. The spectrum of ASASSN-15ts is that of a normal Type Ia at peak. After correcting for the redshift of the host galaxy, we measure a Si II 6355 expansion velocity of -14000 km/s.

  19. Description of a new species and the karyotype of the cavernicolous millipede Pseudonannolene Silvestri and the karyotype of Pseudonannolene strinatti Mauriès (Diplopoda, Pseudonannolenida, Pseudonannolenidae

    Directory of Open Access Journals (Sweden)

    Carmem Silvia Fontanetti

    1996-01-01

    Full Text Available Pseudonannolene tocaiensis, sp.n. is described from Brazil, São Paulo, Itirapina. The karyotypes of P. tocaiensis, sp.n. and P. strinatti Mauriès, 1974 are also presented, both species are found in cave environments. P. tocaiensis has 2n=20, XY and P. strinatti, 2n=16; it was not possible to observe the sex determination mechanism in the latter.

  20. Common Sense, Ontology and Time: A Critique of Lynne Rudder Baker's View of Temporal Reality

    Directory of Open Access Journals (Sweden)

    L. Nathan Oaklander

    Full Text Available ABSTRACT The aim of this paper is twofold: First, to critically discuss Lynne Rudder's Baker BA-theory of time, and second to contrast it with the R-theory (after Russell. In the course of my discussion I will contrast three different methodological approaches regarding the relation between common sense and ontology; clarify Russell's authentic view in contrast to the B-theory which is McTaggart's misrepresentation of Russell, and consider how the R-theory can respond to objections Baker makes to eternalism (as she understands it.

  1. TS/EL ELECTRICAL WORK REQUEST FORM

    CERN Multimedia

    TS Department

    2008-01-01

    To facilitate the processing of requests for minor electrical installation work to be carried out by the TS/EL group, a new procedure designed to improve contacts and exchange of information with customers has been set up. The procedure comprises a check to determine whether the TS/EL or the TS/FM group is responsible for the area where the electrical work is to be done. If the work is to be performed by the EL group, an on-line request form must be completed. The following steps must be completed: On a web browser, use the link http://ts-dep.web.cern.ch/ts-dep/groups/el/el.htm In the left-hand menu choose ‘Demande de Travaux Electriques’ Enter the building number to check which group to contact and click ‘FIND’ If the area is: Under FM’s responsibility:\tCall 77777 Under EL’s responsibility:\tClick the link to the work form, complete it and send it (click ‘ENVOYER’) IMPORTANT This form is for minor electrical installation requests only. Please call 72201 in t...

  2. Identification and Mapping of Soils, Vegetation, and Water Resources of Lynn County, Texas, by Computer Analysis of ERTS MSS Data

    Science.gov (United States)

    Baumgardner, M. F.; Kristof, S. J.; Henderson, J. A., Jr.

    1973-01-01

    Results of the analysis and interpretation of ERTS multispectral data obtained over Lynn County, Texas, are presented. The test site was chosen because it embodies a variety of problems associated with the development and management of agricultural resources in the Southern Great Plains. Lynn County is one of ten counties in a larger test site centering around Lubbock, Texas. The purpose of this study is to examine the utility of ERTS data in identifying, characterizing, and mapping soils, vegetation, and water resources in this semiarid region. Successful application of multispectral remote sensing and machine-processing techniques to arid and seminarid land-management problems will provide valuable new tools for the more than one-third of the world's lands lying in arid-semiarid regions.

  3. North American Regional Security: A Trilateral Framework. By Richard J. Kilroy, Jr., Abelardo Rodriquez Sumano, and Todd S. Hataley, Boulder, CO: Lynne Rienner Press, 2013.

    Directory of Open Access Journals (Sweden)

    Robert Stewart-Ingersoll

    2014-04-01

    Full Text Available North American Regional Security: A Trilateral Framework. By Richard J. Kilroy, Jr., Abelardo Rodriquez Sumano, and Todd S. Hataley, Boulder, CO: Lynne Rienner Press, 2013. ISBN 978-1-58826-854-9.

  4. Wartime Women Rape: A Means of Moral Attack and Emasculation in Lynn Nottage’s Ruined

    Directory of Open Access Journals (Sweden)

    Elaff Ganim Salih

    2016-05-01

    Full Text Available Women rape at warfare was considered a consequence of war in the social, literary and political world for a long period of time. Some criminals of rape escaped justice and others were persecuted on the basis that they were involved in mass rape because it was a natural consequence of war. But, women are targeted with rape in time of war because they are the symbolic representation of a culture, ethnicity, and the unifying fabric of their people and nation. The objective of this paper is to show that war rape is not a result of war; instead it is a means of human destruction through moral attack and emasculation. It aims to show that women rape in warfare is neither a misogynist act nor a sexual violence but it is a pre-planned weapon used strategically and systematically to fulfill certain political and military agenda. The study focuses on the sexual abuse of women in the Democratic Republic of Congo in time of war in Lynn Nottage’s Pulitzer Prize play, Ruined (2007. The study applies Jonathan Gottschall’s Strategic Rape theory, which highlights war rape as a pre-planned military strategy. The enemy emasculates men and attacks them morally by raping their women. Consequently, men’s failure to protect their women causes them to give up resistance, leave their lands and families because of shame and humiliation. The study concludes that women rape in time of war is a tactic followed by conquerors intentionally to facilitate and guarantee the achievement of certain pre-planned goals as was the case of mass rape in the DRC. Keywords: women rape, strategy, emasculation, moral attack, strategic rape theory

  5. Bureau de documentation TS/EL/DO

    CERN Document Server

    Dujardin, M

    2004-01-01

    Le bureau de documentation a comme responsabilité de fournir et manager toute la documentation nécessaire au groupe TS-EL. Ce travail utilise des outils CAO (EUCLID- AUTOCAD) et de gestion de base de donnés ORACLE (GESMAR,EDMS) largement utilisé dans le département TS mais aussi des applications métiers tel que le transfert des donnés CAO vers les bases de données, le cheminement automatique ou la schématique électrique. La section se concentre sur des études de grands ensembles et l'intégration 3D des équipements électriques. Les études de services généraux sont généralement sous-traitées. Le projet LHC occupe actuellement la quasi totalité de nos ressources. Pour mener à bien les études électriques du LHC, caractérisées par une définition tardive des besoins et de nombreuses modifications, une structure souple et réactive a été mis en place : Une cellule CAO 3D EUCLID, en charge des layouts d'équipements et des cheminements, en relation avec l'intégration, et une cellule d'é...

  6. Rezension zu: Stephanie Lynn Budin: The Myth of Sacred Prostitution in Antiquity. Cambridge u.a.: Cambridge University Press 2008.

    Directory of Open Access Journals (Sweden)

    Julian Herbert Köck

    2010-01-01

    Full Text Available Stephanie Lynn Budin liefert mit vorliegender Studie einen wichtigen Beitrag zur Debatte um die Existenz von Tempelprostitution im Altertum. Systematisch untersucht sie die Quellen zur Tempelprostitution und kann weitgehend überzeugend darlegen, dass die betreffenden Stellen nicht für die Existenz von Tempelprostitution im Altertum sprechen, sondern nur aufgrund von tendenziösen Interpretationen so verstanden wurden. Dabei greift die Studie die Ergebnisse anderer Wissenschaftler/-innen auf, bietet aber – besonders zu Herodot und Strabon – auch neue Erkenntnisse.

  7. Stephanie Lynn Budin: The Myth of Sacred Prostitution in Antiquity. Cambridge u.a.: Cambridge University Press 2008. Stephanie Lynn Budin: The Myth of Sacred Prostitution in Antiquity. Cambridge u.a.: Cambridge University Press 2008.

    Directory of Open Access Journals (Sweden)

    Julian Herbert Köck

    2010-03-01

    Full Text Available Stephanie Lynn Budin liefert mit vorliegender Studie einen wichtigen Beitrag zur Debatte um die Existenz von Tempelprostitution im Altertum. Systematisch untersucht sie die Quellen zur Tempelprostitution und kann weitgehend überzeugend darlegen, dass die betreffenden Stellen nicht für die Existenz von Tempelprostitution im Altertum sprechen, sondern nur aufgrund von tendenziösen Interpretationen so verstanden wurden. Dabei greift die Studie die Ergebnisse anderer Wissenschaftler/-innen auf, bietet aber – besonders zu Herodot und Strabon – auch neue Erkenntnisse.Stephanie Lynn Budin’s study offers up an important contribution to the debate on the existence of temple prostitution during antiquity. She systematically examines the sources on temple prostitution and can demonstrate, fairly convincingly, that the passages in question do not prove the existence of temple prostitution during antiquity, but instead have been merely understood to do so based on tendentious interpretations. In so doing, the study takes up conclusions offered by other scholars, but it also provides – especially when it comes to Herodotus and Strabo – new insights.

  8. Electrophysiological Characterization of Ts6 and Ts7, K+ Channel Toxins Isolated through an Improved Tityus serrulatus Venom Purification Procedure

    Directory of Open Access Journals (Sweden)

    Felipe A. Cerni

    2014-02-01

    Full Text Available In Brazil, Tityus serrulatus (Ts is the species responsible for most of the scorpion related accidents. Among the Ts toxins, the neurotoxins with action on potassium channels (α-KTx present high interest, due to their effect in the envenoming process and the ion channel specificity they display. The α-KTx toxins family is the most relevant because its toxins can be used as therapeutic tools for specific target cells. The improved isolation method provided toxins with high resolution, obtaining pure Ts6 and Ts7 in two chromatographic steps. The effects of Ts6 and Ts7 toxins were evaluated in 14 different types of potassium channels using the voltage-clamp technique with two-microelectrodes. Ts6 toxin shows high affinity for Kv1.2, Kv1.3 and Shaker IR, blocking these channels in low concentrations. Moreover, Ts6 blocks the Kv1.3 channel in picomolar concentrations with an IC50 of 0.55 nM and therefore could be of valuable assistance to further designing immunosuppressive therapeutics. Ts7 toxin blocks multiple subtypes channels, showing low selectivity among the channels analyzed. This work also stands out in its attempt to elucidate the residues important for interacting with each channel and, in the near future, to model a desired drug.

  9. Intertidal biofilm distribution underpins differential tide-following behavior of two sandpiper species (Calidris mauri and Calidris alpina) during northward migration

    Science.gov (United States)

    Jiménez, Ariam; Elner, Robert W.; Favaro, Corinna; Rickards, Karen; Ydenberg, Ronald C.

    2015-03-01

    The discovery that some shorebird species graze heavily on biofilm adds importance to elucidating coastal processes controlling biofilm, as well as impetus to better understand patterns of shorebird use of intertidal flats. Western sandpipers (Calidris mauri) and dunlin (Calidris alpina) stopover in the hundreds of thousands on the Fraser River estuary, British Columbia, Canada, during northward migration to breeding areas. Western sandpipers show greater modification of tongue and bill morphology for biofilm feeding than dunlin, and their diet includes more biofilm. Therefore, we hypothesized that these congeners differentially use the intertidal area. A tide following index (TFI) was used to describe their distributions in the upper intertidal during ebbing tides. Also, we assessed sediment grain size, biofilm (= microphytobenthic or MPB) biomass and invertebrate abundance. Foraging dunlin closely followed the ebbing tide line, exploiting the upper intertidal only as the tide retreated through this area. In contrast, western sandpipers were less prone to follow the tide, and spent more time in the upper intertidal. Microphytobenthic biomass and sediment water content were highest in the upper intertidal, indicating greater biofilm availability for shorebirds in the first 350 m from shore. Invertebrate density did not differ between sections of the upper intertidal. Overall, western sandpiper behaviour and distribution more closely matched MPB biofilm availability than invertebrate availability. Conservation of sandpipers should consider physical processes, such as tides and currents, which maintain the availability of biofilm, a critical food source during global migration.

  10. Private I: The Protagonists in Lynne Rae Perkins' Newbery-Winning Novel Are Shy, Talented, and Extremely Thoughtful--Kind of Like the Author

    Science.gov (United States)

    Barstow, Barb

    2006-01-01

    Lynne Rae Perkins is the author of "Criss Cross," which won the Newbery Medal, the nation's most prestigious prize for children's book. Perkins grew up in Cheswick, PA, near Pittsburgh, majored in printmaking at Penn State, and attended grad school at the University of Wisconsin-Milwaukee. She moved to Leelanau County, MI, in 1987 with her…

  11. Theory Meets Theatre Practice: Making a Difference to Public Health Programmes in Southern Africa. Professor Lynn Dalrymple--South African Scholar, Activist, Educator

    Science.gov (United States)

    Durden, Emma; Tomaselli, Keyan

    2012-01-01

    Lynn Dalrymple is a pioneer in the field of communication about HIV and AIDS in South Africa. Her work has influenced practitioners, researchers and thinkers in South Africa and beyond. This review explores Dalrymple's background as a teacher in the rural areas of Zululand in South Africa, and how she came to apply theatre theory for one of the…

  12. Abelian Yang-Baxter deformations and TsT transformations

    Science.gov (United States)

    Osten, David; van Tongeren, Stijn J.

    2017-02-01

    We prove that abelian Yang-Baxter deformations of superstring coset σ models are equivalent to sequences of commuting TsT transformations, meaning T dualities and coordinate shifts. Our results extend also to fermionic deformations and fermionic T duality, and naturally lead to a TsT subgroup of the superduality group OSp (db ,db | 2df). In cases like AdS5 ×S5, fermionic deformations necessarily lead to complex models. As an illustration of inequivalent deformations, we give all six abelian deformations of AdS3. We comment on the possible dual field theory interpretation of these (super-)TsT models.

  13. Abelian Yang-Baxter Deformations and TsT transformations

    CERN Document Server

    Osten, David

    2016-01-01

    We prove that abelian Yang-Baxter deformations of superstring coset sigma models are equivalent to sequences of commuting TsT transformations, meaning T dualities and coordinate shifts. Our results extend also to fermionic deformations and fermionic T duality, and naturally lead to a TsT subgroup of the superduality group OSp(d_b,d_b|2d_f). In cases like AdS_5 x S^5, fermionic deformations necessarily lead to complex models. As an illustration of inequivalent deformations, we give all six abelian deformations of AdS_3. We comment on the possible dual field theory interpretation of these (super-)TsT models.

  14. HADÎTS SEBAGAI LANDASAN PEMBENTUKAN TRADISI ISLAMI

    OpenAIRE

    Karimullah Karimullah

    2013-01-01

    Abstract:   Hadîts both of as basic of Islam law, in the implementation be sure as basic in daily life, that it will appear many dialectics between Hadîts with a local tradition and culture what have been present in the society, even it has been strong roof in the society. Because of that, in this discussion, it will discuss about the function of hadîts in acomodation various of tradition in society, in order to appropriate theory of Islam. The problems what becom main study in this working p...

  15. Abelian Yang–Baxter deformations and TsT transformations

    Directory of Open Access Journals (Sweden)

    David Osten

    2017-02-01

    Full Text Available We prove that abelian Yang–Baxter deformations of superstring coset σ models are equivalent to sequences of commuting TsT transformations, meaning T dualities and coordinate shifts. Our results extend also to fermionic deformations and fermionic T duality, and naturally lead to a TsT subgroup of the superduality group OSp(db,db|2df. In cases like AdS5×S5, fermionic deformations necessarily lead to complex models. As an illustration of inequivalent deformations, we give all six abelian deformations of AdS3. We comment on the possible dual field theory interpretation of these (super-TsT models.

  16. TS WEBSITE AND SOCIAL MEDIA ANALYTICS- DECEMBER 2016

    Data.gov (United States)

    Department of Veterans Affairs — This PowerPoint included accomplishments reached in December 2016, along with how many TS users and Pulse users there are currently. Not only does this PowerPoint...

  17. TS WEBSITE AND SOCIAL MEDIA ANALYTICS NOVEMBER 2016

    Data.gov (United States)

    Department of Veterans Affairs — This PowerPoint included accomplishments reached in November 2016, along with how many TS users and Pulse users there are currently. Not only does this PowerPoint...

  18. T=S Model to Simulate Regional Economic Development

    Institute of Scientific and Technical Information of China (English)

    WangQing; ChenGuo-jie; ZhangYu; ChenYong

    2003-01-01

    This paper proposes a mechanism theory on regional development by using a modified Logistic model. It reveals regional evolution is an integration of fluctuation in temporal dimension and disparity in spatial dimension. T=S model is established by using Logistic model to simulate the growth of per capita GDP in China from 1990 to 1999. The result shows that T=S model accurately simulates the tracks of economic growth.

  19. Variable (Tg, Ts) Measurements of Alkane Dissociative Sticking Coefficients

    Science.gov (United States)

    Valadez, Leticia; Dewitt, Kristy; Abbott, Heather; Kolasinski, Kurt; Harrision, Ian

    2006-03-01

    Dissociative sticking coefficients S(Tg, Ts) for CH4 and C2H6 on Pt(111) have been measured as a function of gas temperature (Tg) and surface temperature (Ts) using an effusive molecular beam. Microcanonical unimolecular rate theory (MURT) was employed to extract transition state characteristics [e.g., E0(CH4) = 52.5±3.5 kJ/mol-1 and E0(C2H6) = 26.5±3 kJ/mol-1]. MURT allows our S(Tg, Ts) values to be directly compared to other supersonic molecular beam and thermal equilibrium sticking measurements. The S(Tg, Ts) depend strongly on Ts, however, only for CH4 is a strong Tg dependence observed. The fairly weak Tg dependence for C2H6 suggests that vibrational mode specific behavior and/or molecular rotations play stronger roles in the dissociative chemisorption of C2H6 than they do for CH4. Interestingly, thermal S(Tg=Ts) predictions based on MURT modeling of our CH4/Pt(111) data are three orders of magnitude higher than recent thermal equilibrium measurements on supported Pt nanocrystallite catalysts [J. M. Wei, E. Iglesia, J. Phys. Chem. B 108, 4094 (2004)].

  20. HADÎTS SEBAGAI LANDASAN PEMBENTUKAN TRADISI ISLAMI

    Directory of Open Access Journals (Sweden)

    Karimullah Karimullah

    2013-08-01

    Full Text Available Abstract:   Hadîts both of as basic of Islam law, in the implementation be sure as basic in daily life, that it will appear many dialectics between Hadîts with a local tradition and culture what have been present in the society, even it has been strong roof in the society. Because of that, in this discussion, it will discuss about the function of hadîts in acomodation various of tradition in society, in order to appropriate theory of Islam. The problems what becom main study in this working paper, that is: the first, what are the forms of interaction hadîts in context with tradition in society. Second, context pattern what can connected between both of them. In order to, in acomodation process or Hadîts aculturation into locak tradition in society don’t make trouble what more become wide and dangerous. Until development local culture-tradition what in the society we able to build agree with theory of Islam. Some concept what can be solution, when we want to development Islamic studies especially in Indonesia. That aculturation process between Hadîts and tradition culture what have been development in society become harmonie one of unity, with apply four context system, that is islamization, pribumization, negotiation, and tolerance. And the last will formed a construction process and aculturation of local traditions what is not appropriate with theory of Islam become a tradition Islamic.   Key Words: Hadîts, tradisi, Islamisasi, pribumisasi, negosiasi, dan toleransi  

  1. Application of TS-1 in cyclohexanone ammoximation reaction%应用于环己酮氨肟化反应的TS-1研究进展

    Institute of Scientific and Technical Information of China (English)

    任文杰; 周向葵; 贾会敏; 李识寒; 张卫峰

    2014-01-01

    The ammoximation of cyclohexanone has become an inevitable trend of technological development of producing caprolactam,and the preparation of Titanium Silicalite-1(TS-1) has become the most important technology of the cyclohexanone ammoximation. However,it is rather expensive and difficult to prepare TS-1,which restricts the industrial production of caprolactam and needs further improvement. Focusing on this issue,this paper reviews the preparation of TS-1, including modified TS-1,TS-1 with large particle diameter,TS-1 compounds,the shaping of TS-1, as well as other technology related to the preparation of TS-1. The future development of the cyclohexanone ammoximation shall be aimed to improve the catalytic activity of TS-1,solve the recycling of TS-1 on an industrial scale,improve the stability and yield of TS-1,and reduce the costs.%环己酮氨肟化工艺是己内酰胺新技术发展的必然趋势之一,而钛硅分子筛TS-1的制备是环己酮氨肟化工艺的核心技术。但由于TS-1合成成本昂贵,合成条件苛刻,制备重复性差,制约了工业化的发展,仍需要不断的技术进步。本文针对这一主题,对环己酮氨肟化反应所需的TS-1催化剂的制备包括TS-1的改性、大颗粒TS-1的制备、复合TS-1的制备、TS-1的成型及其他的TS-1制备工艺等技术进行了系统综述。在环己酮氨肟化反应中,提高TS-1的催化活性、解决工业上TS-1的分离和回收难题、提高TS-1制备的稳定性和产量、降低成本等是未来TS-1研究的发展趋势。

  2. Establishment and analysis of global gridded Tm Ts relationship model

    Institute of Scientific and Technical Information of China (English)

    Zeying Lan; Bao Zhang; Yichao Geng

    2016-01-01

    In ground-based GPS meteorology, Tm is a key parameter to calculate the conversion factor that can convert the zenith wet delay (ZWD) to precipitable water vapor (PWV). It is generally acknowledged that Tm is in an approximate linear relationship with surface temperature Ts, and the relationship presents regional variation. This paper employed sliding average method to calculate correlation coefficients and linear regression co-efficients between Tm and Ts at every 2? ? 2.5? grid point using Ts data from European Centre for Medium-Range Weather Forecasts (ECMWF) and Tm data from “GGOS Atmo-sphere”, yielding the grid and bilinear interpolation-based TmGrid model. Tested by Tm and Ts grid data, Constellation Observation System of Meteorology, Ionosphere, and Climate (COSMIC) data and radiosonde data, the TmGrid model shows a higher accuracy relative to the Bevis Tm ? Ts relationship which is widely used nowadays. The TmGrid model will be of certain practical value in high-precision PWV calculation.

  3. T-S Fuzzy Control of Uncertain Chaotic Vibration

    Directory of Open Access Journals (Sweden)

    Abdelkrim Boukabou

    2012-01-01

    Full Text Available We present in this paper a novel and unified control approach that combines intelligent fuzzy logic methodology with predictive method for controlling chaotic vibration of a class of uncertain chaotic systems. We first introduce prediction into each subsystem of Takagi Sugeno (T-S fuzzy IF-THEN rules and then present a unified T-S predictive fuzzy model for chaos control. The proposed controller can successfully stabilize the chaos and track the desired targets. The simulation results illustrate its effectiveness.

  4. Learning Problems and the TS Child [and] Specific Classroom Strategies and Techniques for Students with Tourette Syndrome [and] Techniques To Aid Students with TS in Completing Written Assignments.

    Science.gov (United States)

    Davidovicz, Herman; And Others

    Three fact sheets provide parents and educators with basic information on Tourette Syndrome (TS). The first sheet is titled "Learning Problems and the TS Child" and is by Herman Davidovicz, a neuropsychologist. It notes the high frequency of attention deficit disorders and learning problems in children with TS and provides information…

  5. TS-05: 150 lines of java with high architectural complexity

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak

    2005-01-01

    In the short time span available in a software architecture course, it is difficult to find a software system that is both interesting from an architectural perspective and so small that it does not overwhelm the students.We present TS-05 which is a bare 150 line Java "toy-system" that never...

  6. Move of Purchasing Offices TS – AB* – AT*

    CERN Multimedia

    FI Department

    2008-01-01

    The TS – AB* - AT* Purchasing Offices and the Purchasing Pool have moved to Building 5 – 2nd and *3rd floors. The phone and fax numbers are unchanged. We apologize for any inconvenience caused by the move. Thank you for your understanding. Finance Department – Purchasing Service.

  7. Hybrid TS fuzzy modelling and simulation for chaotic Lorenz system

    Institute of Scientific and Technical Information of China (English)

    Li De-Quan

    2006-01-01

    The projection of the chaotic attractor observed from the Lorenz system in the X-Z plane is like a butterfly, hence the classical Lorenz system is widely known as the butterfly attractor, and has served as a prototype model for studying chaotic behaviour since it was coined. In this work we take one step further to investigate some fundamental dynamic behaviours of a novel hybrid Takagi-Sugeno (TS) fuzzy Lorenz-type system, which is essentially derived from the delta-operator-based TS fuzzy modelling for complex nonlinear systems, and contains the original Lorenz system of continuous-time TS fuzzy form as a special case. By simply and appropriately tuning the additional parametric perturbations in the two-rule hybrid TS fuzzy Lorenz-type system, complex (two-wing) butterfly attractors observed from this system in the three dimensional (3D) X-Y-Z space are created, which have not yet been reported in the literature, and the forming mechanism of the compound structures have been numerically investigated.

  8. Emotion of Physiological Signals Classification Based on TS Feature Selection

    Institute of Scientific and Technical Information of China (English)

    Wang Yujing; Mo Jianlin

    2015-01-01

    This paper propose a method of TS-MLP about emotion recognition of physiological signal.It can recognize emotion successfully by Tabu search which selects features of emotion’s physiological signals and multilayer perceptron that is used to classify emotion.Simulation shows that it has achieved good emotion classification performance.

  9. Novel method for synthesis of titanium silicalite-1 (TS-1)

    Institute of Scientific and Technical Information of China (English)

    ZHOU, Ji- Cheng; WANG, Xiang-Sheng

    2000-01-01

    Titanium silicalite-1 (TS-1) was easily synthesized using inorganic silicon and titanium source, tetrapropylammonium bromide (TPABr) or TPAOH as templating molecule, NH3·H2O, HDA or TEAOH etc. as base sources. In this system,TPA + cations (come from TPABr or TPAOH) served as templating agents to direct the MFI structure. NH3H2O, TEAOH or HDA etc. provides the alkalinity necessary for crystallization. X-ray diffraction, UV-Vis, IR spectroscopies, SEM,29Si MAS NMR showed that the zeolites obtained possessed all the structural characteristics of TS-1, and titanium atoms were introduced into the framework in TS-1. This material was proved to have high crystallinity and high catalytic activity to allyl chloride epoxidation and propylene epoxidation. All the samples synthesized had similar catalytic properties with a standard TS-1 through compared inorganic reactant system with organic synthesis system using propylene epoxidation.The effects of silicon source and TPABr/SiO2 ratio were discussed.

  10. The 'Don'ts' of Web Page Design.

    Science.gov (United States)

    Balas, Janet L.

    1999-01-01

    Discusses online resources that focus on what not to do in Web page design. "Don'ts" include: making any of the top 10 mistakes identified by Nielsen, qualifying for a "muddie" award for bad Web sites, forgetting to listen to users, and forgetting accessibility. A sidebar lists the Web site addresses for the nine resources…

  11. Effects induced by Tityus serrulatus scorpion venom and its toxins TsTX-I and TsTX-V on the rat isolated retractor penis muscle.

    Science.gov (United States)

    Bomfim, José Henrique G G; de Godoy, Márcio A F; Giglio, José R; de Oliveira, Ana Maria; Arantes, Eliane C

    2005-03-01

    The aims of the present study were to investigate the pharmacological effects induced by Tityus serrulatus venom (TsV) and its fractions and to compare with the effects induced by pure alpha (TsTX-V) and beta (TsTX-I) toxins isolated from TsV on rat retractor penis muscle (RPM). TsV, fractions X, XI, XIIa, XIIb (0.01-100 microg/ml) and TsTX-V (1 nmol/l-10 micromol/l) induced concentration-dependent contractions. Prazosin and guanethidine or tetrodotoxin (TTX, 5 micromol/l, 30 min) completely abolished these contractions, suggesting complete dependence on sympathetic nerves. TsV or fractions X, XI, XIIa, XIIb (0.01- 100 microg/ml), TsTX-I and TsTX-V (1 nmol/l-10 micromol/l) induced concentration-dependent relaxations in the precontracted RPM. TTX or N(omega)-nitro-L-arginine methyl ester (L-NAME, 100 micromol/l, 30 min) completely abolished the relaxations. Our results suggest that most of TsV-derivated toxins induce contraction and relaxation on RPM by sympathetic and NANC nitrergic nerve stimulation. Noteworthy, TsTX-I only induces relaxation on RPM suggesting that this protein selectively acts on inhibitory nerves.

  12. A new species of Tarracoblaniulus Mauriès & Vicente, 1977: description, postembryonic development, life cycle, and spatial distribution (Diplopoda, Julida, Blaniulidae

    Directory of Open Access Journals (Sweden)

    Martínez, H.

    2009-06-01

    Full Text Available Tarracoblaniulus phantasmanus n. sp. is described from Tarragona province, Spain and compared with the only known other species known in the genus, T. lagari Mauriès & Vicente, 1977, from which it differs mainly in having only 5, instead of 15 or more, straight spines on the posterior gonopod. The female vulva (unknown in T. lagari is very different from all known blaniulid vulvae. Based on a large number of specimens, the postembryonic development (euanamorphosis from stadium II onward is described. This is highly variable, with three to six apodous body rings in stadium IV, which is the most variable number so far recorded in Blaniulidae. Accordingly, specimens beyond stadium VIII could not be assigned to a specific stadium. At least some males are morphologically distinguishable in stadium IV, morphologically mature males appear in stadium VIII, possibly already in stadium VII. The life cycle of the new species is tentatively suggested to involve at least three years. The monthly mean density of the total population was 28.82 ind/m2 across the whole soil profile. Statistically significant differences in density values between months and Spearman’s rank correlation analyses between the monthly mean values of density and temperature show that T. phantasmanus presents a maximum density in the coldest months and a minimum one in the summer. Significant differences between monthly mean densities of different soil levels and the Usher index values show that during the spring and summer T. phantasmanus is concentrated in the mineral horizon A. In autumn, during winter and up to early spring, the population shows a clear tendency to move up towards horizon H and horizon L/F. Concerning horizontal distribution, Morisita index monthly values for each of the horizons indicate that the species is distributed in patches.Se describe Tarracoblaniulus phantasmanus n. sp., especie encontrada en la provincia de Tarragona (España, y se compara con la única

  13. Effect of solvents on propylene epoxidation over TS-1 catalyst

    Institute of Scientific and Technical Information of China (English)

    Yulong WU; Qingshan LIU; Xueli SU; Zhentao MI

    2008-01-01

    Solvents have an important effect on the epoxidation of propylene catalyzed by TS-1. The experimental results show that, in different solvents, the catalytic activity of epoxidation is in the following order: methanol > 2-propanol > 2-butanol > acetoni-trile > acetone > tetrahydrofuran. Based on the reaction mechanism, the effects of solvents on the epoxidation were studied from eight aspects, which included the electronic effect, the steric effect, the polarity of solvent, the effect of solvent on sorption and diffusion of reactant, the oxidation of alcohol, the etherification of PO, the deactivation of TS-1 and the solubility of propylene in the solvents. The electronic effect, steric effect and the polarity of solvent were considered to be the main aspects. This work may provide theoretical guidance for choosing solvents for these kinds of reactions and also may serve as basis for further industrialization.

  14. Measurement of the CKM matrix element |V_ts

    CERN Document Server

    Unverdorben, Christopher Gerhard

    This is the first direct measurement of the CKM matrix element |V_ts|, using data collected by the ATLAS detector in 2012 at √s=8 TeV pp-collisions with a total integrated luminosity of 20.3 fb⁻¹. The analysis is based on 112171 reconstructed tt̅ candidate events in the lepton+jets channel, having a purity of 90.0 %. 183 tt̅→WWbs̅ decays are expected (charge conjugation implied), which are available for the extraction of the CKM matrix element |V_ts|². To identify these rare decays, several observables are examined, such as the properties of jets, tracks and of b-quark identification algorithms. Furthermore, the s-quark hadrons K0s are considered, reconstructed by a kinematic fit. The best observables are combined in a multivariate analysis, called "boosted decision trees". The responses from Monte Carlo simulations are used as templates for a fit to data events yielding a significance value of 0.7σ for t→s+W decays. An upper limit of |V_ts|² < 1.74 % at 95 % confidence level is set, includi...

  15. 75 FR 38168 - Hazardous Materials: International Regulations for the Safe Transport of Radioactive Material (TS...

    Science.gov (United States)

    2010-07-01

    ... the Safe Transport of Radioactive Material (TS-R-1); Draft Revision Available for Comment AGENCY... International Atomic Energy Agency's (IAEA) ``Regulations for the Safe Transport of Radioactive Material'' (TS-R... Radioactive Material (TS-R-1), to promote the safe and secure transportation of radioactive material. The...

  16. Tomato EF-Ts(mt), a functional mitochondrial translation elongation factor from higher plants.

    Science.gov (United States)

    Benichou, Mohamed; Li, Zhengguo; Tournier, Barthélémy; Chaves, Ana; Zegzouti, Hicham; Jauneau, Alain; Delalande, Corinne; Latché, Alain; Bouzayen, Mondher; Spremulli, Linda L; Pech, Jean-Claude

    2003-10-01

    Ethylene-induced ripening in tomato (Lycopersicon esculentum) resulted in the accumulation of a transcript designated LeEF-Ts(mt) that encodes a protein with significant homology to bacterial Ts translational elongation factor (EF-Ts). Transient expression in tobacco and sunflower protoplasts of full-length and truncated LeEF-Ts(mt)-GFP fusion constructs and confocal microscopy observations clearly demonstrated the targeting of LeEF-Ts(mt) to mitochondria and not to chloroplasts and the requirement for a signal peptide for the proper sorting of the protein. Escherichia coli recombinant LeEF-Ts(mt) co-eluted from Ni-NTA resins with a protein corresponding to the molecular weight of the elongation factor EF-Tu of E. coli, indicating an interaction with bacterial EF-Tu. Increasing the GDP concentration in the extraction buffer reduced the amount of EF-Tu in the purified LeEF-Ts(mt) fraction. The purified LeEF-Ts(mt) stimulated the poly(U)-directed polymerization of phenylalanine 10-fold in the presence of EF-Tu. Furthermore, LeEF-Ts(mt) was capable of catalysing the nucleotide exchange reaction with E. coli EF-Tu. Altogether, these data demonstrate that LeEF-Ts(mt) encodes a functional mitochondrial EF-Ts. LeEF-Ts(mt) represents the first mitochondrial elongation factor to be isolated and functionally characterized in higher plants.

  17. Electrophysiological characterization of Ts6 and Ts7, K⁺ channel toxins isolated through an improved Tityus serrulatus venom purification procedure.

    Science.gov (United States)

    Cerni, Felipe A; Pucca, Manuela B; Peigneur, Steve; Cremonez, Caroline M; Bordon, Karla C F; Tytgat, Jan; Arantes, Eliane C

    2014-02-28

    In Brazil, Tityus serrulatus (Ts) is the species responsible for most of the scorpion related accidents. Among the Ts toxins, the neurotoxins with action on potassium channels (α-KTx) present high interest, due to their effect in the envenoming process and the ion channel specificity they display. The α-KTx toxins family is the most relevant because its toxins can be used as therapeutic tools for specific target cells. The improved isolation method provided toxins with high resolution, obtaining pure Ts6 and Ts7 in two chromatographic steps. The effects of Ts6 and Ts7 toxins were evaluated in 14 different types of potassium channels using the voltage-clamp technique with two-microelectrodes. Ts6 toxin shows high affinity for Kv1.2, Kv1.3 and Shaker IR, blocking these channels in low concentrations. Moreover, Ts6 blocks the Kv1.3 channel in picomolar concentrations with an IC50 of 0.55 nM and therefore could be of valuable assistance to further designing immunosuppressive therapeutics. Ts7 toxin blocks multiple subtypes channels, showing low selectivity among the channels analyzed. This work also stands out in its attempt to elucidate the residues important for interacting with each channel and, in the near future, to model a desired drug.

  18. Review of Calculation vs. Context: Quantitative Literacy and Its Implications for Teacher Education by Bernard L. Madison and Lynn Arthur Steen (Editors

    Directory of Open Access Journals (Sweden)

    Maura B. Mast

    2009-07-01

    Full Text Available Madison, Bernard L. and Steen, Lynn Arthur (Eds.. Calculation vs. Context: Quantitative Literacy and Its Implications for Teacher Education. (Washington, DC: Mathematical Association of America, 2009. 197 pp. Softcover. ISBN 978-0-88385-908-7. Available free on the MAA website at http://www.maa.org/ql/calcvscontext.htmlThe papers in Calculation vs. Context discuss the role of quantitative literacy in the K-12 curriculum and in teacher education. The papers present a varied set of perspectives and address three themes: the changing environment of education in American society; the challenges, and the necessity, of preparing teachers to teach quantitative literacy and of including quantitative literacy in the K-12 education; and cross-disciplinary approaches to quantitative literacy. While the conclusion reached by several of the authors is that the best place to teach quantitative literacy is at the college level, the book offers serious considerations of how quantitative literacy can and should inform the K-12 curriculum. The book also marks a turning point in the quantitative literacy movement as “QL explorers,” as Lynn Steen calls them, move beyond issues of definitions and content to a discussion of how to bring quantitative literacy into a broader setting.

  19. VLF signal anomalies dues to TS and Hurricanes

    Science.gov (United States)

    Nait Amor, Samir

    2017-04-01

    VLF signal propagates by multiples reflection in the Earth-Ionosphere wave guide. It constitutes a powerful tool to study the lower region of the ionosphere, the D region. This technique was applied to study perturbations related to the solar flares effect, TGF, the connection between TLEs and Early events.... In this contribution I will present a new results on the evidence of signal perturbations associated with TS and Hurricanes. A wavelet spectral analysis is applied to the signal amplitude to search for eventual Atmospheric Gravity wave which may be the origin of the signal perturbations.

  20. 全天侯智能Seals TS3

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Seals族强悍的=810G标准TS3搭载Android智能系统,配备双512MB内存以及拥有康宁Gorilla--代耐刮玻璃覆盖的35英寸多点触控屏,能与大豢行业应用软件适配。为油气勘探、电力、建筑、工程等特种行业用户提供全天候的工作能力。

  1. Patterning processes in aggregates of Hydra cells visualized with the monoclonal antibody, TS19.

    Science.gov (United States)

    Sato, M; Bode, H R; Sawada, Y

    1990-10-01

    The monoclonal antibody, TS19, (Heimfeld et al., 1985), labels the apical surface of ectodermal epithelial cells of tentacles and lower peduncles in Hydra. To investigate the patterning process in a tissue whose original pattern was completely destroyed, the TS19 staining pattern was examined in developing aggregates of Hydra cells. Two types of aggregates were prepared. G-aggregates were made from tissue of the gastric portion of animals and RG-aggregates from gastric tissue allowed to regenerate for 24 hr before making aggregates. G-aggregates were initially TS19-negative, and later dim and uniformly TS19-positive. Thereafter, TS19 staining broke up into brightly stained and unstained regions. The brightly staining regions developed into head or foot structures. The TS19 pattern in RG-aggregates developed differently. Since the initial aggregates contained cells of regenerating tips, they started with TS19-positive cells as well as TS19-negative cells. The numbers of brightly staining TS19-positive cells increased with time. Some patches of these cells developed into head or foot structures, while others did not. These results and a simulation using a reaction-diffusion model suggest that the changes in activation levels affected the temporal changes in the pattern of TS19 staining, and that the de novo pattern formation in hydra can be explained in terms of a process involving activation and inhibition properties.

  2. Exploring the integration of ERP and ISO / TS16949 international quality system%探究ERP与ISO/TS16949国际质量体系融台

    Institute of Scientific and Technical Information of China (English)

    王峰

    2015-01-01

    ISO/TS16949是汽车行业重要的国际规范,1SO/TS 16949适用于直接零部件制造商以及汽车整车厂,ISO/TS16949不仅十分关注质量系统保证能力以及产品质量,更对质量管理系统是否具有有效性十分关注,ISO/TS16949国际质量体系将顾客作为中心,坚持预防为主.ISO/TS16949将满足顾客需求作为前提和基础,进而建立起持续改进质量具有高效性的质量管理体系.很多大型企业均将ISO/TS16949作为质量管理和制造的标准.探究了ERP与ISO/TS16949国际质量体系的融合.

  3. Comparative genomic analysis reveals a novel mitochondrial isoform of human rTS protein and unusual phylogenetic distribution of the rTS gene

    Directory of Open Access Journals (Sweden)

    McGuire John J

    2005-09-01

    Full Text Available Abstract Background The rTS gene (ENOSF1, first identified in Homo sapiens as a gene complementary to the thymidylate synthase (TYMS mRNA, is known to encode two protein isoforms, rTSα and rTSβ. The rTSβ isoform appears to be an enzyme responsible for the synthesis of signaling molecules involved in the down-regulation of thymidylate synthase, but the exact cellular functions of rTS genes are largely unknown. Results Through comparative genomic sequence analysis, we predicted the existence of a novel protein isoform, rTS, which has a 27 residue longer N-terminus by virtue of utilizing an alternative start codon located upstream of the start codon in rTSβ. We observed that a similar extended N-terminus could be predicted in all rTS genes for which genomic sequences are available and the extended regions are conserved from bacteria to human. Therefore, we reasoned that the protein with the extended N-terminus might represent an ancestral form of the rTS protein. Sequence analysis strongly predicts a mitochondrial signal sequence in the extended N-terminal of human rTSγ, which is absent in rTSβ. We confirmed the existence of rTS in human mitochondria experimentally by demonstrating the presence of both rTSγ and rTSβ proteins in mitochondria isolated by subcellular fractionation. In addition, our comprehensive analysis of rTS orthologous sequences reveals an unusual phylogenetic distribution of this gene, which suggests the occurrence of one or more horizontal gene transfer events. Conclusion The presence of two rTS isoforms in mitochondria suggests that the rTS signaling pathway may be active within mitochondria. Our report also presents an example of identifying novel protein isoforms and for improving gene annotation through comparative genomic analysis.

  4. Composite repairs qualification according to ISO/TS 24817

    Energy Technology Data Exchange (ETDEWEB)

    Meniconi, Luiz C.M.; Perrut, Valber A. [Petroleo Brasileiro S.A. (PETROBRAS/CENPES), Rio de Janeiro, RJ (Brazil). Centro de Pesquisas

    2009-07-01

    Composite repairs for metallic pipes from three different suppliers were evaluated according to ISO Technical Specification TS 24817. The intended application scenarios are offshore production plants, but the design methodology is also applicable to onshore pipelines and pipework. The evaluation covered all the relevant mechanical properties and established the maximum application temperatures for each repair system. The tests also considered the application of composite repair sleeves to metallic pipes with through thickness defects, by measuring the strain energy release rates of the composite-metal interfaces. The test campaigns aimed to verify the applicability of the recently published ISO document, and to implement it as the routine procedure for composite repairs evaluation within PETROBRAS. The tests also addressed the influence of metallic pipe surface preparation on the final properties of the repair sleeves, especially in relation to the long term behavior of leaking pipes repaired by means of composite materials. (author)

  5. REAC/TS Radiation Accident Registry: An Overview

    Energy Technology Data Exchange (ETDEWEB)

    Doran M. Christensen, DO, REAC/TS Associate Director and Staff Physician Becky Murdock, REAC/TS Registry and Health Physics Technician

    2012-12-12

    Over the past four years, REAC/TS has presented a number of case reports from its Radiation Accident Registry. Victims of radiological or nuclear incidents must meet certain dose criteria for an incident to be categorized as an “accident” and be included in the registry. Although the greatest numbers of “accidents” in the United States that have been entered into the registry involve radiation devices, the greater percentage of serious accidents have involved sealed sources of one kind or another. But if one looks at the kinds of accident scenarios that have resulted in extreme consequence, i.e., death, the greater share of deaths has occurred in medical settings.

  6. Composite repairs qualification according to ISO/TS 24817

    Energy Technology Data Exchange (ETDEWEB)

    Meniconi, Luiz C.M.; Perrut, Valber A. [Petroleo Brasileiro S.A. (PETROBRAS/CENPES), Rio de Janeiro, RJ (Brazil). Centro de Pesquisas

    2009-07-01

    Composite repairs for metallic pipes from three different suppliers were evaluated according to ISO Technical Specification TS 24817. The intended application scenarios are offshore production plants, but the design methodology is also applicable to onshore pipelines and pipework. The evaluation covered all the relevant mechanical properties and established the maximum application temperatures for each repair system. The tests also considered the application of composite repair sleeves to metallic pipes with through thickness defects, by measuring the strain energy release rates of the composite-metal interfaces. The test campaigns aimed to verify the applicability of the recently published ISO document, and to implement it as the routine procedure for composite repairs evaluation within PETROBRAS. The tests also addressed the influence of metallic pipe surface preparation on the final properties of the repair sleeves, especially in relation to the long term behavior of leaking pipes repaired by means of composite materials. (author)

  7. TS-CE-MW: past, present and future work

    CERN Document Server

    Morton, R

    2008-01-01

    The technological challenges of the LHC and other CERN based experiments require a flexible and ever changing infrastructure. The construction, maintenance and modification of the CERN facilities are performed by the Management and Works section of the TS Civil Engineering Group. The variety and difficulty of many of our challenges can be seen from the case studies presented from past projects and current activities. The transition from the construction phase of the LHC to operations represents a major change to the way we will work in the future. Here we present some of the preparations we are making for the running phase of the LHC which will allow us to continue the upkeep of the CERN infrastructure and respond to client demands throughout CERN.

  8. The Verification and Validation of the Ray-tracing of Bag of Triangles (BoTs)

    Science.gov (United States)

    2015-02-01

    The Verification and Validation of the Ray-tracing of Bag of Triangles ( BoTs ) by Charith Ranawake ARL-CR-0761 February 2015...Ground, MD 22105 ARL-CR-0761 February 2015 The Verification and Validation of the Ray-tracing of Bag of Triangles ( BoTs ) Charith...and Validation of the Ray-tracing of Bag of Triangles ( BoTs ) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S

  9. Reconstitution of Qbeta RNA replicase from a covalently bonded elongation factor Tu-Ts complex

    DEFF Research Database (Denmark)

    Brown, S; Blumenthal, T

    1976-01-01

    (C) and Qbeta RNA normally and had approximately the same specific activity as control enzyme. Denatured Qbeta replicase formed with crosslinked EF-Tu-Ts was found to renature much more rapidly than untreated enzyme and, in contrast to normal replicase, its renaturation was not inhibited by GDP. The results...... by its ability to replace EF-Tu and EF-Ts in the renaturation of denatured Qbeta replicase. A sample of Qbeta replicase with crosslinked EF-Tu-Ts replacing the individual elongation factors was prepared. Although it lacked EF-Tu and EF-Ts activities, it could initiate transcription of both poly...

  10. Using multilevel growth curve modeling to examine emotional modulation of temporal summation of pain (TS-pain) and the nociceptive flexion reflex (TS-NFR).

    Science.gov (United States)

    Rhudy, Jamie L; Martin, Satin L; Terry, Ellen L; Delventura, Jennifer L; Kerr, Kara L; Palit, Shreela

    2012-11-01

    Emotion can modulate pain and spinal nociception, and correlational data suggest that cognitive-emotional processes can facilitate wind-up-like phenomena (ie, temporal summation of pain). However, there have been no experimental studies that manipulated emotion to determine whether within-subject changes in emotion influence temporal summation of pain (TS-pain) and the nociceptive flexion reflex (TS-NFR, a physiological measure of spinal nociception). The present study presented a series of emotionally charged pictures (mutilation, neutral, erotic) during which electric stimuli at 2 Hz were delivered to the sural nerve to evoke TS-pain and TS-NFR. Participants (n=46 healthy; 32 female) were asked to rate their emotional reactions to pictures as a manipulation check. Pain outcomes were analyzed using statistically powerful multilevel growth curve models. Results indicated that emotional state was effectively manipulated. Further, emotion modulated the overall level of pain and NFR; pain and NFR were highest during mutilation and lowest during erotic pictures. Although pain and NFR both summated in response to the 2-Hz stimulation series, the magnitude of pain summation (TS-pain) and NFR summation (TS-NFR) was not modulated by picture-viewing. These results imply that, at least in healthy humans, within-subject changes in emotions do not promote central sensitization via amplification of temporal summation. However, future studies are needed to determine whether these findings generalize to clinical populations (eg, chronic pain).

  11. Ni2+-PAA Adsorbent for Purifying 6His-OmpTS Recombinant Protein

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Functional Ni2+-polyacrylic acid (Ni2+-PAA) adsorbent has been prepared for metal chelate affinity chromatography. DNA elements coding for adjacent histidines were fused to the Aeromonas hydrophila ompTS gene. Subsequent expression in E. coli resulted in the production of hybrid protein 6His-OmpTS that could be purified by Ni2+-PAA affinity chromatography.

  12. Selective synthesis of thiodiglycol dicarboxylic acid esters via -TsOH/C-catalysed direct esterification

    Indian Academy of Sciences (India)

    Dahong Jiang; Min Huang

    2012-09-01

    The esterification of thiodiglycol and long alkyl-chain carboxylic acids is reported. Reaction of thiodiglycol with carboxylic acid via -TsOH/C-catalysed direct esterification afforded thiodiglycol dicarboxylic acid esters in good yields and chemoselectivity. The use of immobilized -TsOH on activated carbon as catalyst is crucial for the transformation.

  13. Evaluation of the egg transmission and pathogenicity of Mycoplasma gallisepticum isolates genotyped as ts-11.

    Science.gov (United States)

    Armour, Natalie K; Ferguson-Noel, Naola

    2015-01-01

    Live Mycoplasma gallisepticum vaccines are used for the control of respiratory disease, egg production losses and egg transmission associated with M. gallisepticum infection in long-lived poultry. The first field case of apparent increased virulence and vertical transmission of ts-11, a live M. gallisepticum vaccine, has been reported. In that study a M. gallisepticum isolate from the broiler progeny of ts-11-vaccinated breeders was genotyped as ts-11 by sequence analysis of four different genetic targets and Random Amplified Polymorphic DNA and found to be significantly more virulent than ts-11 vaccine. The objective of the current study was to evaluate the rate of egg transmission and pathogenicity of ts-11 vaccine and isolates recovered from ts-11-vaccinated breeders (K6222B) and their broiler progeny (K6216D) which had been genotyped as ts-11. Groups of 28-week-old specific pathogen-free chickens at 87% average weekly egg production were inoculated with sterile broth media (negative controls), ts-11 vaccine, K6222B, K6216D or R strain (positive controls) by eye-drop and aerosol. K6216D transmitted via the egg at an average rate of 4.0% in the third and fourth weeks post-infection, while egg transmission of K6222B and ts-11 vaccine was not detected. M. gallisepticum was isolated from the air sacs, ovaries and oviducts of hens infected with K6216D and K6222B, but not from those infected with ts-11 vaccine. K6216D and K6222B both induced respiratory signs and significantly more tracheal colonization and more severe tracheal and air sac lesions than ts-11 vaccine (P ≤ 0.05). There were no substantial differences in the egg production of ts-11, K6216D and K6222B infected groups. These results provide the first conclusive evidence of transovarian transmission of an isolate genotyped as ts-11 and indicate that isolates genotyed as ts-11 vary in their virulence and ability to transmit via the egg.

  14. Adaptive Control of MEMS Gyroscope Based on T-S Fuzzy Model

    Directory of Open Access Journals (Sweden)

    Yunmei Fang

    2015-01-01

    Full Text Available A multi-input multioutput (MIMO Takagi-Sugeno (T-S fuzzy model is built on the basis of a nonlinear model of MEMS gyroscope. A reference model is adjusted so that a local linear state feedback controller could be designed for each T-S fuzzy submodel based on a parallel distributed compensation (PDC method. A parameter estimation scheme for updating the parameters of the T-S fuzzy models is designed and analyzed based on the Lyapunov theory. A new adaptive law can be selected to be the former adaptive law plus a nonnegative in variable to guarantee that the derivative of the Lyapunov function is smaller than zero. The controller output is implemented on the nonlinear model and T-S fuzzy model, respectively, for the purpose of comparison. Numerical simulations are investigated to verify the effectiveness of the proposed control scheme and the correctness of the T-S fuzzy model.

  15. A virtual computing infrastructure for TS-CV SCADA systems

    CERN Document Server

    Poulsen, S

    2008-01-01

    In modern data centres, it is an emerging trend to operate and manage computers as software components or logical resources and not as physical machines. This technique is known as â€ワvirtualisation” and the new computers are referred to as â€ワvirtual machines” (VMs). Multiple VMs can be consolidated on a single hardware platform and managed in ways that are not possible with physical machines. However, this is not yet widely practiced for control system deployment. In TS-CV, a collection of VMs or a â€ワvirtual infrastructure” is installed since 2005 for SCADA systems, PLC program development, and alarm transmission. This makes it possible to consolidate distributed, heterogeneous operating systems and applications on a limited number of standardised high-performance servers in the Central Control Room (CCR). More generally, virtualisation assists in offering continuous computing services for controls and maintaining performance and assuring quality. Implementing our systems in a vi...

  16. Protective immune response induced by co-immunization with the Trichinella spiralis recombinant Ts87 protein and a Ts87 DNA vaccine.

    Science.gov (United States)

    Yang, Yaping; Yang, Xiaodi; Gu, Yuan; Wang, Yunyun; Zhao, Xi; Zhu, Xinping

    2013-05-20

    Ts87 is an immunodominant antigen that induces protective immunity against Trichinella spiralis larval challenge in mice. To determine if a combination of recombinant Ts87 protein and its coding DNA induces a stronger immune response in female C57BL/6 mice were immunized with 100 μg of recombinant Ts87 protein plus its coding DNA cloned in vector pVAX1, or the same amount of recombinant protein or DNA only. Mouse subclass IgG responses showed that both co-immunized and single-immunized mice produced a balanced IgG2a/IgG1 (Th1/Th2) response. T-cell proliferation in co-immunized animals was significantly higher than in single-immunized mice. Cytokine profiling in the co-immunization group showed a significant increase in the levels of IL-2, IL-4, IL-6 and IFN-γ in the splenocytes of mice upon stimulation with the recombinant Ts87 protein; however, the expression of IL-17 was down-regulated. Challenge results showed that mice immunized with the recombinant Ts87 protein and its coding DNA produced reduced the muscle larval burden to a greater extent (43.8%) than the groups immunized with only the protein (39.7%) or the DNA (9.7%). A better Th1/Th2 immune response and consequent protection induced by co-immunization with the recombinant Ts87 protein and its coding DNA may result from an adjuvant effect of DNA and a specific persistent expression of Ts87.

  17. Therapeutic profile of T11TS vs. T11TS+MiADMSA: a hunt for a more effective therapeutic regimen for arsenic exposure.

    Science.gov (United States)

    Chaudhuri, Suhnrita; Acharya, Sagar; Chatterjee, Sirshendu; Kumar, Pankaj; Singh, Manoj Kumar; Bhattacharya, Debanjan; Basu, Anjan Kumar; Dasgupta, Shyamal; Flora, S J S; Chaudhuri, Swapna

    2012-01-01

    Arsenic exposure is a serious health hazard worldwide. We have previously established that it may result in immune suppression by upregulating Th2 cytokines while downregulating Th1 cytokines and causing lymphocytic death. Treatment modalities for arsenic poisoning have mainly been restricted to the use of chelating agents in the past. Only recently have combination therapies using a chelating agent in conjunction with other compounds such as anti-oxidants, micronutrients and various plant products, been introduced. In the present study, we used T11TS, a novel immune potentiating glycopeptide alone and in combination with the sulfhydryl-containing chelator, mono-iso-amyl-dimarcaptosuccinic acid (MiADMSA) as a therapeutic regimen to combat arsenic toxicity in a mouse model. Results indicated that Th1 cytokines such as TNF-α, IFNγ, IL12 and the Th2 cytokines such as IL4, IL6, IL10 which were respectively downregulated and upregulated following arsenic induction were more efficiently restored to their near normal levels by T11TS alone in comparison with the combined regimen. Similar results were obtained with the apoptotic proteins studied, FasL, BAX, BCL2 and the caspases 3, 8 and 9, where again T11TS proved more potent than in combination with MiADMSA in preventing lymphocyte death. The results thus indicate that T11TS alone is more efficient in immune re-establishment after arsenic exposureas compared to combination therapy with T11TS+MiADMSA.

  18. Scientific Communication for Positive Action: Do's and Don'ts

    Science.gov (United States)

    Sanquini, A.; Wood, M. M.

    2015-12-01

    Natural hazard presentations often highlight disasters that may ensue from natural processes when mitigation or preparedness actions are not taken. Examples include images of raging fires, collapsed buildings, and flooded urban areas. Research has shown that this makes presentations more interesting and more memorable. Such images are the stock and trade of disaster reporting by the media. Unfortunately, it may also trigger avoidance and denial in the audience, resulting in preparedness reduction; the opposite effect of what may have been intended by the speaker. Recent social research has provided insight into a better approach. The theory of communicating actionable risk posits that people will take action against hazards when they know what to do, think it would work, and know someone who did it. This approach was recently applied in an intervention designed to motivate earthquake-resistant construction in Kathmandu Valley, Nepal. Social theory further suggests that a tendency towards action is strengthened by hearing a consistent message over time, and by providing the audience with an appropriate opportunity to seek out relevant information. This presentation shows how, by taking this transdisciplinary step, scientists can make small changes in their hazard communication, thereby acting as positive influencers of change. A summary of "do's" and "don'ts" is given for reference. 1. Show examples of what to do. 2. Show effectiveness of actions. 3. Give sense of knowing someone who did it. 4. Deliver consistent message, repeatedly. 5. Give opportunity for more information. DON'T: 1. Make the disaster the star. 2. Contradict other communications.

  19. Molecular evolution of paclitaxel biosynthetic genes TS and DBAT of Taxus species.

    Science.gov (United States)

    Hao, Da Cheng; Yang, Ling; Huang, Beili

    2009-03-01

    Evolutionary patterns of sequence divergence were analyzed in genes from the conifer genus Taxus (yew), encoding paclitaxel biosynthetic enzymes taxadiene synthase (TS) and 10-deacetylbaccatin III-10 beta-O-acetyltransferase (DBAT). N-terminal fragments of TS, full-length DBAT and internal transcribed spacer (ITS) were amplified from 15 closely related Taxus species and sequenced. Premature stop codons were not found in TS and DBAT sequences. Codon usage bias was not found, suggesting that synonymous mutations are selectively neutral. TS and DBAT gene trees are not consistent with the ITS tree, where species formed monophyletic clades. In fact, for both genes, alleles were sometimes shared across species and parallel amino acid substitutions were identified. While both TS and DBAT are, overall, under purifying selection, we identified a number of amino acids of TS under positive selection based on inference using maximum likelihood models. Positively selected amino acids in the N-terminal region of TS suggest that this region might be more important for enzyme function than previously thought. Moreover, we identify lineages with significantly elevated rates of amino acid substitution using a genetic algorithm. These findings demonstrate that the pattern of adaptive paclitaxel biosynthetic enzyme evolution can be documented between closely related Taxus species, where species-specific taxane metabolism has evolved recently.

  20. Tegafur/gimeracil/oteracil (TS-1 induced Stevens–Johnson syndrome: Case report

    Directory of Open Access Journals (Sweden)

    Satoko Minakawa

    2013-09-01

    Full Text Available TS-1 is an oral fluoropyrimidine anticancer drug that contains tegafur, gimeracil, and oteracil. A 78-year-old Japanese male who was diagnosed with carcinoma of the oral floor (rT4aN0M0 was prescribed a standard dose of TS-1 (80 mg/day. On Day 8 after administration of TS-1, an eruption developed. There was erythema, along with vesicles and erosions involving the lip, face, neck, trunk, limbs, and genitals. The drug-induced lymphocyte stimulation test (DLST for TS-1 was negative on the 23rd day, but positive on the 43rd day (20 days after discontinuing prednisolone. The condition was diagnosed as Stevens–Johnson syndrome due to TS-1 because of the clinical course and laboratory results. This case and 24 cases previously reported in the literature were analyzed. The types of drug eruption were drug-related lupus (9 cases, acral erythema (7 cases, scleroderma-like skin lesion (2 cases, Stevens–Johnson syndrome (2 cases, lichenoid eruption (1 case, purpura (1 case, lichen planus (1 case, erythema multiforme (1 case, hypopigmentation (1 case and toxic epidermal necrolysis (1 case, respectively. In view of the increasing usage of TS-1 in several common cancers, clinicians should be aware of drug eruptions due to TS-1.

  1. Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome.

    Science.gov (United States)

    Best, Tyler K; Cramer, Nathan P; Chakrabarti, Lina; Haydar, Tarik F; Galdzicki, Zygmunt

    2012-02-01

    GABAergic dysfunction is implicated in hippocampal deficits of the Ts65Dn mouse model of Down syndrome (DS). Since Ts65Dn mice overexpress G-protein coupled inward-rectifying potassium (GIRK2) containing channels, we sought to evaluate whether increased GABAergic function disrupts the functioning of hippocampal circuitry. After confirming that GABA(B)/GIRK current density is significantly elevated in Ts65Dn CA1 pyramidal neurons, we compared monosynaptic inhibitory inputs in CA1 pyramidal neurons in response to proximal (stratum radiatum; SR) and distal (stratum lacunosum moleculare; SLM) stimulation of diploid and Ts65Dn acute hippocampal slices. Synaptic GABA(B) and GABA(A) mediated currents evoked by SR stimulation were generally unaffected in Ts65Dn CA1 neurons. However, the GABA(B)/GABA(A) ratios evoked by stimulation within the SLM of Ts65Dn hippocampus were significantly larger in magnitude, consistent with increased GABA(B)/GIRK currents after SLM stimulation. These results indicate that GIRK overexpression in Ts65Dn has functional consequences which affect the balance between GABA(B) and GABA(A) inhibition of CA1 pyramidal neurons, most likely in a pathway specific manner, and may contribute to cognitive deficits reported in these mice.

  2. Electrostatic channeling in P. falciparum DHFR-TS: Brownian dynamics and Smoluchowski modeling.

    Science.gov (United States)

    Metzger, Vincent T; Eun, Changsun; Kekenes-Huskey, Peter M; Huber, Gary; McCammon, J Andrew

    2014-11-18

    We perform Brownian dynamics simulations and Smoluchowski continuum modeling of the bifunctional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (P. falciparum DHFR-TS) with the objective of understanding the electrostatic channeling of dihydrofolate generated at the TS active site to the DHFR active site. The results of Brownian dynamics simulations and Smoluchowski continuum modeling suggest that compared to Leishmania major DHFR-TS, P. falciparum DHFR-TS has a lower but significant electrostatic-mediated channeling efficiency (?15-25%) at physiological pH (7.0) and ionic strength (150 mM). We also find that removing the electric charges from key basic residues located between the DHFR and TS active sites significantly reduces the channeling efficiency of P. falciparum DHFR-TS. Although several protozoan DHFR-TS enzymes are known to have similar tertiary and quaternary structure, subtle differences in structure, active-site geometry, and charge distribution appear to influence both electrostatic-mediated and proximity-based substrate channeling.

  3. Saugus River and Tributaries, Lynn Malden, Revere and Saugus, Massachusetts. Flood Damage Reduction. Volume 7. Appendix J. Feasibility Study and EIS/EIR Comments and Responses. Section B. Attachments

    Science.gov (United States)

    1989-12-01

    project also provides the o~portunity to further protect the valuable resources in the estuary, not otherwise afforded without the project. Miese ...Lynn side of the Saucus River about 700 feet easterly of the General Edwards Bridge, traverses in a generally southerly direction for approximately...of Carey Circle and would traverse in an easterly direction a distance of about 230 feet ending at Reach "B". A stone revetment at elevation 13.2 feet

  4. Modeling and Stability Analysis for Non-linear Network Control System Based on T-S Fuzzy Model

    Institute of Scientific and Technical Information of China (English)

    ZHANG Hong; FANG Huajing

    2007-01-01

    Based on the T-S fuzzy model, this paper presents a new model of non-linear network control system with stochastic transfer delay. Sufficient criterion is proposed to guarantee globally asymptotically stability of this two-levels T-S fuzzy model. Also a T-S fuzzy observer of NCS is designed base on this two-levels T-S fuzzy model. All these results present a new approach for networked control system analysis and design.

  5. Ts...sT transformation on $AdS_{5}\\times S^{5}$ background

    CERN Document Server

    Rashkov, R C; Yang, Y; Yang, Yi

    2005-01-01

    In this paper we consider a simple generalization of Lunin and Maldacena procedure of generating new string backgrounds based on TsT-transformations. We study multi-shift $Ts... sT$ transformations applied to backgrounds with at least two U(1) isometries. We prove that the string currents in any two backgrounds related by Ts...sT-transformations are equal. Performing this procedure to the $AdS_{5}\\times S^{5}$ we find a new background and study some properties of the semiclassical strings.

  6. Increased male reproductive success in Ts65Dn “Down syndrome” mice

    OpenAIRE

    Moore, Clara S.; Hawkins, Charles; Franca, Arianna; Lawler, Ann; Devenney, Benjamin; Das, Ishita; Reeves, Roger H.

    2010-01-01

    The Ts65Dn mouse is trisomic for orthologs of about half the genes on Hsa21. A number of phenotypes in these trisomic mice parallel those in humans with trisomy 21 (Down syndrome), including cognitive deficits due to hippocampal malfunction that are sufficiently similar to human that “therapies” developed in Ts65Dn mice are making their way to human clinical trials. However, the impact of the model is limited by availability. Ts65Dn cannot be completely inbred and males are generally consider...

  7. WIAMan Technology Demonstrator Sensor Codes Conforming to International Organization for Standardization/Technical Standard (ISO/TS) 13499

    Science.gov (United States)

    2016-03-01

    Standardization/Technical Standard ( ISO /TS) 13499 by Michael Tegtmeyer Approved for public release; distribution is unlimited. NOTICES Disclaimers The findings...International Organization for Standardization/Technical Standard ( ISO /TS) 13499 by Michael TegtmeyerWIAMan Engineering Office, ARL Approved for public...WIAMan Technology Demonstrator Sensor Codes Conforming to International Organization for Standardization/Technical Standard ( ISO /TS) 13499 Michael

  8. 40 CFR Table 21 to Subpart G of... - Average Storage Temperature (Ts) as a Function of Tank Paint Color

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Average Storage Temperature (Ts) as a Function of Tank Paint Color 21 Table 21 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL... (Ts) as a Function of Tank Paint Color Tank Color Average Storage Temperature (Ts) White TA a =...

  9. PDM技术在ISO/TS 16949:2002实施中的应用%Application of PDM in Implementation of ISO/TS 16949:2002

    Institute of Scientific and Technical Information of China (English)

    王林琳; 晁代章; 杜东坡

    2007-01-01

    ISO/TS16949:2002标准的贯彻实施与企业的信息化密切相关,必须借助于大规模的计算机处理系统.PDM(Product Data Management)系统的工作流程管理和大规模文件数据处理功能,为实施工作提供了有力的技术支持和软件平台,辅助TS16949标准在产品设计、生产过程中顺利开展.

  10. Impaired T-cell functions in aged guinea-pigs restored by thymostimulin (TS).

    Science.gov (United States)

    Falchetti, R; Cafiero, C; Caprino, L

    1982-01-01

    The age-related changes of different T-cell activities in guinea pigs and the effect of Thymostimulin (TS), a thymus extract, on the immunocompetence of these cells was studied. Mitogen-induced proliferation of peripheral blood lymphocytes was increased by TS in vitro. The intraperitoneal administration of TS (5 mg/kg) to aged animals restored the helper function of T lymphocytes and enhanced the reactivity to mitogens of both peripheral blood lymphocytes and spleen lymphocytes. The data obtained suggest that as in other species, there is an age-associated decline of immunological response, in guinea pigs too, probably due to a deficiency of thymic hormone(s) and that TS could correct this deficiency.

  11. Field Support System (FS-AID) and Working Capital Fund Tracking System (WCF-TS)

    Data.gov (United States)

    US Agency for International Development — The Field Support System (FS-AID) and Working Capital Fund Tracking System (WCF-TS) are two modules of a single data management system that share common tables and...

  12. Association between CMMI-DEV 1.2 AND ISO/TS 16949

    Directory of Open Access Journals (Sweden)

    Altamar Urbanetz de Araújo Albanez

    2014-05-01

    Full Text Available The automotive sector is one of the most daring in terms of quality, requiring ISO/TS 16949 certification. Nevertheless, there are companies those lose their certification or develop only some improvements due to a lack of enough maturity to maintain it and gaps in continuous improvement guidelines. Whereas CMMI is one of the diagnostic methods of maturity, the aim of this work is to identify the feasibility of linking the ISO/TS 16949 with the CMMI-DEV 1.2. The method used consists in review PDPs, quality certification and process maturity and then associate these two models. The analysis concludes that a company certified by ISO/TS not necessarily even reaches the maturity level 2 in CMMI. Moreover, while the CMMI model shows those items not covered and demand their development, ISO/TS only encourages "continuous improvement" without a plan or diagnostics for the company operationally achieve it.

  13. Tackling fever and inflammation of unknown origin: the do's and don'ts.

    Science.gov (United States)

    Vanderschueren, S; Knockaert, D

    2014-12-01

    Fever and inflammation of unknown origin continue to challenge the clinician. The differential diagnosis is broad and potential diagnostic pitfalls abound. To guide the approach, the authors discuss the do's and don'ts.

  14. Heterogeneous oxidation of cyclohexanone catalyzed by TS-1:Combined experimental and DFT studies

    Institute of Scientific and Technical Information of China (English)

    Changjiu Xia; Xingtian Shu; Long Ju; Yi Zhao; Hongyi Xu; Bin Zhu; Feifei Gao; Min Lin; Zhenyu Dai; Xiaodong Zou

    2015-01-01

    The reaction mechanism of the oxidation of cyclohexanone catalyzed by titanium silicate zeolite TS-1 using aqueous H2O2 as the oxidant was investigated by combining density function theory (DFT) calculations with experimental studies. DFT calculations showed that H2O2 was adsorbed and activated at the tetrahedral Ti sites. By taking into account the adsorption energy, molecular size, steric hindrance and structural information, a reaction mechanism of Baeyer-Villiger oxidation catalyzed by TS-1 that involves the activation of H2O2 was proposed. Experimental studies showed that the major products of cyclohexanone oxidation by H2O2 catalyzed by a hollow TS-1 zeolite wereε-carprolactone, 6-hydroxyhexanoic acid, and adipic acid. These products were analyzed by GC-MS and were in good agreement with the proposed mechanism. Our studies showed that the reaction mechanism on TS-1 zeolite was different from that on Sn-beta zeolite.

  15. Konstantin Päts ja NSV Liidu Tallinna saatkond / Magnus Ilmjärv

    Index Scriptorium Estoniae

    Ilmjärv, Magnus, 1961-

    1999-01-01

    Järg Sep/13,14,15,16,17,18,20,21,22,22 lk. 17,21,17,18,18,16,17,21,18,14. Päts kui Nõukogude saatkonna lobitegija. Välisminister Pusta kangutamine. Pätsi info venelastele J. Tõnissoni kohta. Balti riikide vahelise koostöö takistamine. J. Puhk tõmmati venelaste mõjusfääri. Päts nõuab Eesti valitsuselt uut kaubanduslepingut venelastega

  16. Causal Analysis of ISO/TS16949 Efforts in Automotive Industry

    Science.gov (United States)

    Zakuan, Norhayati; Ariff, Mohd Shoki Md; Norfian Alifiah, Mohd; Mohd Yusof, Shari; Zameri Mat Saman, Muhamad

    2014-06-01

    The principal aim of this study is to determine the impact of ISO/TS16949 efforts on total quality management (TQM) and the ISO/TS16949 efforts relationship in Malaysian automotive industry. A survey method was employed to collect data using English version for Malaysian respondents. Exploratory factor analysis and reliability analysis empirically verified and validated the underlying items of TQM, ISO/TS16949 and organizational performance. Structural equation modeling was employed to test the proposed model. Data analysis revealed that TQM implementations have a strong and positive impact on organizational performance through direct relationship as well as through a mediating role of ISO/TS16949 efforts. From the research findings, it is viable to recommend that ISO/TS16949 should be incorporated with philosophy and methods of TQM to achieve better performance. This study proved to be valuable to academic researchers as well as automotive practitioners. It systematically analyzes the mediating effect of ISO/TS16949 efforts on TQM and organizational performance relationship.

  17. 建立ISO/TS 16949质量管理体系初探

    Institute of Scientific and Technical Information of China (English)

    王永泰; 蔡正龙; 尹海燕

    2005-01-01

    @@ 一、什么是ISO/TS16949 ISO/TS16949质量管理标准的全称是"质量管理体系--汽车行业生产件与相关服务件的组织实施ISO9001:2000的特殊要求",英文缩写为ISO/TS16949.ISO/TS16949是国际标准化组织(ISO)与IATF(国际汽车行动小组)于2002年3月1日公布的一项行业性质量体系规范,适用于整个汽车产业的供应链,包括整车厂、零配件厂商以及为汽车行业提供产品的钢铁、玻璃和电子产品的供应商等.我国政府等同采用了该技术规范,于2003年1月17日发布推荐性国家标准GB/T18305-2003 idt ISO/TS16949:2002,并于2003年6月1日开始实施.

  18. Dysfunction of the ubiquitin-proteasome system in the cerebellum of aging Ts65Dn mice.

    Science.gov (United States)

    Necchi, Daniela; Lomoio, Selene; Scherini, Elda

    2011-12-01

    In the cerebellum of adult-aging Ts65Dn mice, a murine model of Down syndrome, Purkinje cells undergo degeneration. Searching for the cause of Purkinje cell degeneration, we have studied the ubiquitin-proteasome system (UPS) in the cerebellum of aging Ts65Dn mice. Inhibition of UPS is sufficient to induce neuron degeneration and death. Proteasome chymotrypsin-like proteolytic activity was reduced by 35% in the cerebellum of Ts65Dn mice in comparison with euploid animals. Accordingly, Western blot analysis of ubiquitin showed an increase in ubiquitinated proteins. Immunocytochemistry for ubiquitin revealed strongly positive intranuclear inclusions in Purkinje cells and large neurons of cerebellar nuclei. The Western blot analysis of ubiquitin in nuclear protein extracts confirmed the increase of ubiquitinated proteins in the cell nuclei. After FUS immunocytochemistry, large intranuclear inclusions were visible in Purkinje cells and large neurons of cerebellar nuclei in Ts65Dn mice. Together, data indicate a possible role for proteasome inhibition in the cerebellar neurodegeneration in Ts65Dn mice.

  19. Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current.

    Science.gov (United States)

    Best, Tyler K; Siarey, Richard J; Galdzicki, Zygmunt

    2007-01-01

    Down syndrome (DS) is the most common nonheritable cause of mental retardation. DS is the result of the presence of an extra chromosome 21 and its phenotype may be a consequence of overexpressed genes from that chromosome. One such gene is Kcnj6/Girk2, which encodes the G-protein-coupled inward rectifying potassium channel subunit 2 (GIRK2). We have recently shown that the DS mouse model, Ts65Dn, overexpresses GIRK2 throughout the brain and in particular the hippocampus. Here we report that this overexpression leads to a significant increase ( approximately 2-fold) in GABA(B)-mediated GIRK current in primary cultured hippocampal neurons. The dose response curves for peak and steady-state GIRK current density is significantly shifted left toward lower concentrations of baclofen in Ts65Dn neurons compared with diploid controls, consistent with increased functional expression of GIRK channels. Stationary fluctuation analysis of baclofen-induced GIRK current from Ts65Dn neurons indicated no significant change in single-channel conductance compared with diploid. However, significant increases in GIRK channel density was found in Ts65Dn neurons. In normalized baclofen-induced GIRK current and GIRK current kinetics no difference was found between diploid and Ts65Dn neurons, which suggests unimpaired mechanisms of interaction between GIRK channel and GABA(B) receptor. These results indicate that increased expression of GIRK2 containing channels have functional consequences that likely affect the balance between excitatory and inhibitory neuronal transmission.

  20. Identification and mitigation of T-S waves using localized dynamic surface modification

    Science.gov (United States)

    Amitay, Michael; Tuna, Burak A.; Dell'Orso, Haley

    2016-06-01

    The control of transition from a laminar to a turbulent flow over a flat plate using localized dynamic surface modifications was explored experimentally in Rensselaer Polytechnic Institute's subsonic wind tunnel. Dynamic surface modification, via a pair of Piezoelectrically Driven Oscillating Surface (PDOS) actuators, was used to excite and control the T-S wave over a flat plate. Creating an upstream, localized small disturbance at the most amplified frequency of fact = 250 Hz led to phase-locking the T-S wave. This enabled observation of the excited T-S wave using phase-locked stereoscopic particle image velocimetry. The growth of the T-S wave as it moved downstream was also measured using this technique (25% growth over four wavelengths of the excited wave). Activation of a downstream PDOS actuator (in addition to the upstream PDOS) at the appropriate amplitude and phase shift resulted in attenuation of the peak amplitude of the coherent velocity fluctuations (by up to 68%) and a substantial reduction of the degree of coherence of the T-S wave. Since the PDOS actuators used in this work were localized, the effect of the control strategy was confined to the region directly downstream of the PDOS actuator.

  1. Estimation of some physical properties for tennessine and tennessine hydride (TsH)

    Science.gov (United States)

    de Farias, Robson Fernandes

    2017-01-01

    In the present work, experimental values of several physical properties for hydrogen halides (including At) are used to obtain, by extrapolation, values of physical properties for tennessine (element 117, Ts) and tennessine hydride (TsH). Using experimental data of Cl, Br, I and At halides, two empirical equations are obtained, allowed us to calculate the ionic and covalent contribution to the bond energy, respectively: Eionic = [μ2h/d3]c210-12 and Ecovalent = [-22.78P + 400.09] + ν(Hsbnd X). Using both equations, as well some empirical trends in the Cl, Br, I and At halides, the values of some physical properties of Ts and TsH are estimated. The frequency energy of the Tssbnd H vibration, ν(Tssbnd H), value is calculated as 20.24 kJ mol-1. For the same bond: μ = 0.24 D; bond distance = 196.76 pm; bond energy = 163.03 kJ mol-1. The polarizability and covalent radius for Ts are estimated as 11.31/10-24 cm3 and 159.76 pm, respectively.

  2. The Standard of ISO/TS 16949- 2nd It's Prospect%ISO/TS 16949-2nd标准及其展望

    Institute of Scientific and Technical Information of China (English)

    吴士权

    2002-01-01

    @@ 根据国际标准化组织(ISO)第176技术委员会(TC176)对660新提案的进程要求,2001年7月26日提出了国际汽车行业的技术规范(TS)表决文件,即形成的ISO/TS 16949-2nd标准的最终草案稿,经ISO成员国近半年的广泛讨论和充分酝酿之后,已于2002年1月16日由正式成员国投票表决,以超过三分之二的赞成票获得了通过.于2002年3月1日正式公布并生效.

  3. ISO9001和ISO/TS16949之联系和差异%The Relationship and Differences between ISO 9001 and ISO/TS 16949

    Institute of Scientific and Technical Information of China (English)

    马学辉

    2010-01-01

    文章主要介绍了ISO9001和ISO/TS16949质量管理体系要求之间的关系和差异以及它们的核心要求和适用性.本文同时介绍了对于它们的认证机构在管理上的差异.

  4. Temperature-sensitive mutant TS 082 of vesicular stomatitis virus. I. Rescue at nonpermissive temperature by uv-irradiated virus

    Energy Technology Data Exchange (ETDEWEB)

    Deutsch, V.; Muel, B.; Brun, G.

    1979-02-01

    Temperature-sensitive mutant ts 082 of vesicular stomatitis virus efficiently complements with all the five known groups of ts mutants. This mutant is analyzed by its rescue at nonpermissive temperature with uv-irradiated virus. The existence of two targets of uv light is demonstrated that suggests rescue is mediated through two different complementation processes, gene/sup +/ survival and structural protein supply by the uv-irradiated virus. This last point is supported by rescue assays carried out in the absence of simultaneous protein synthesis. These features are also shared by the ts mutants of group II, suggesting that ts 082 might belong to complementation group II. The temperature-sensitive defect of ts 082 could be located in a domain different from the one which is mutated in the ts mutants previously classified in group II.

  5. Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin

    Directory of Open Access Journals (Sweden)

    ALA Nencioni

    2009-01-01

    Full Text Available TsTX is an α-type sodium channel toxin that stimulates the discharge of neurotransmitters from neurons. In the present study we investigated which neurotransmitters are released in the hippocampus after TsTX injection and if they are responsible for electrographic or histopathological effects. Microdialysis revealed that the toxin increased glutamate extracellular levels in the hippocampus; however, levels of gamma-aminobutyric acid (GABA, glycine, 5-hydroxyindoleacetic acid (5-HIAA, homovanillic acid (HVA and 3,4-dihydroxyphenylacetic acid (DOPAC were not significantly altered. Neurodegeneration in pyramidal cells of hippocampus and electroencephalographic alterations caused by the toxin were blocked by pretreatment with riluzole, a glutamate release inhibitor. The present results suggest a specific activity of TsTX in the hippocampus which affects only glutamate release.

  6. Reducing The Light Reflected by Silicon Surface Using ZnO/TS Antireflection Coating

    Science.gov (United States)

    Suhandi, Andi; Tayubi, Yuyu R.; Wibowo, Firmanul C.; Arifin, Pepen; Supriyatman

    2017-07-01

    Zinc Oxide (ZnO) thin films was coated on a texturized silicon (TS) surface using a spincoating technique. The TS layer was prepared by a wet etching method using 20 % KOH solution at temperature of 80°C for 5 minutes. To prepared precursor solution for ZnO layer, zinc acetate dehydrate, 2-methoxyethanol and monoethanolamine are used as a starting material, solvent and stabilizer, respectively. The XRD and SEM measurements confirmed that the thin films grown by spincoating technique have a single oriented crystal plane and homogenous surfaces. From photoluminescence measurement found that the optical band gap of grown films to be 3.44 eV. The optical reflectance of the grown films is characterized by UV-VIS spectrometry show that the presence of anti-reflection coating ZnO/TS is proven to reduce the reflection of solar radiation by silicon surface significantly.

  7. Precision control of inverter welding power sources by using T-S fuzzy systems

    Institute of Scientific and Technical Information of China (English)

    Zhou Yiqing; Huang Shisheng; Zhang Hongbing; Wang Zhenmin; Xie Shengmian

    2007-01-01

    The functional relationship of approximation accuracy and number of fuzzy sets is used to find the rational balance point between the control accuracy and the control cost of fuzzy systems. This approach efficiently eliminates the drawback of rapid control cost increase caused by blind increase of fuzzy set number in practical engineering. The sufficient conditions for T-S fuzzy systems as universal approximators are derived. A special T-S fuzzy system that satisfied these conditions is analyzed, and the simulation results show that when the number of fuzzy sets is increased moderately, the model parameters' training epochs can be effectually decreased while the model accuracy improved significantly. A practical welding power source controlled by a T-S fuzzy system is developed with satisfactory experimental results.

  8. A hybrid GA-TS algorithm for open vehicle routing optimization of coal mines material

    Energy Technology Data Exchange (ETDEWEB)

    Yu, S.W.; Ding, C.; Zhu, K.J. [China University of Geoscience, Wuhan (China)

    2011-08-15

    In the open vehicle routing problem (OVRP), the objective is to minimize the number of vehicles and the total distance (or time) traveled. This study primarily focuses on solving an open vehicle routing problem (OVRP) by applying a novel hybrid genetic algorithm and the Tabu search (GA-TS), which combines the GA's parallel computing and global optimization with TS's Tabu search skill and fast local search. Firstly, the proposed algorithm uses natural number coding according to the customer demands and the captivity of the vehicle for globe optimization. Secondly, individuals of population do TS local search with a certain degree of probability, namely, do the local routing optimization of all customer sites belong to one vehicle. The mechanism not only improves the ability of global optimization, but also ensures the speed of operation. The algorithm was used in Zhengzhou Coal Mine and Power Supply Co., Ltd.'s transport vehicle routing optimization.

  9. Controller design of uncertain nonlinear systems based on T-S fuzzy model

    Institute of Scientific and Technical Information of China (English)

    Songtao ZHANG; Shizhen BAI

    2009-01-01

    A robust control for uncertain nonlinear systems based on T-S fuzzy model is discussed in this paper. First, a T-S fuzzy system is adopted to model the uncertain nonlinear systems. Then, for the system with input variables adopting standard fuzzy partitions, the efficient maximal overlapped-rules group (EMORG) is presented, and a new sufficient condition to check the stability of T-S fuzzy system with uncertainty is derived, which is expressed in terms of Linear Matrix Inequalities. The derived stability condition, which only requires a local common positive definite matrix in each EMORG, can reduce the conservatism and difficulty in existing stability conditions. Finally, a simulation example shows the proposed approach is effective.

  10. Constrained predictive control based on T-S fuzzy model for nonlinear systems

    Institute of Scientific and Technical Information of China (English)

    Su Baili; Chen Zengqiang; Yuan Zhuzhi

    2007-01-01

    A constrained generalized predictive control (GPC) algorithm based on the T-S fuzzy model is presented for the nonlinear system. First, a Takagi-Sugeno (T-S) fuzzy model based on the fuzzy cluster algorithm and the orthogonal least square method is constructed to approach the nonlinear system. Since its consequence is linear, it can divide the nonlinear system into a number of linear or nearly linear subsystems. For this T-S fuzzy model, a GPC algorithm with input constraints is presented.This strategy takes into account all the constraints of the control signal and its increment, and does not require the calculation of the Diophantine equations. So it needs only a small computer memory and the computational speed is high. The simulation results show a good performance for the nonlinear systems.

  11. T.S. ELIOT'S MISREADING OF SOME LITERARY SOURCES IN THE WASTE LAND

    Directory of Open Access Journals (Sweden)

    Liem Satya Limanta

    2002-01-01

    Full Text Available A poet cannot be a poet at all if he is not connected with all the poetic tradition before him. This is T.S. Eliot's dictum which he stated in Tradition and the Individual Talent and which he practiced in his work The Waste Land. T.S. Eliot showed his relationship with the past through all the quotations and allusions to mythical, literary, and religious works. His reading of those sources according to Paul de Man cannot avoid misreading or misinterpretation. Harold Bloom has tried to build up a theory of misreading, which he prefers to call misprision, especially applied to and done by poets in The Anxiety of Influence. Throughout this article I shall show how T.S. Eliot has applied some of the ways Bloom describes in reading some of the literary sources, and by so doing Eliot has given new meaning to them.

  12. Monitoring drought in the Monglian Plateau based on NDVI_Ts general space, 2000-2010

    Science.gov (United States)

    Cao, Xiaoming; Wang, Juanle; Gao, Zhiqiang; Ning, Jicai; Shi, Runhe; Gao, Wei

    2013-09-01

    This paper presents a new drought assessment method by modifying the NDVI-Ts space, which named NDVI-Ts general space. Based on this method, the general dry side and wet side equation were established for the period of 2000 and 2010 in the Mongolian Plateau. The results showed that: 1) the NDVI-Ts general space was more stable for monitoring drought than that for the single time Remote Sensing data; 2) Drought mainly distributed in the Mongolian Plateau, In Mongolian Plateau, there was about 75% area of drought; 3) Drought changed in the period of 2000 and 2010. In the year of 2003, the area of severe drought is the smallest. In 2001, the drought is the most serious. The results showed that, the distribution of drought was different in different year. There may be close correlation between the occurrence of drought and precipitation.

  13. Robust Stabilization of T-S Fuzzy Stochastic Descriptor Systems via Integral Sliding Modes.

    Science.gov (United States)

    Li, Jinghao; Zhang, Qingling; Yan, Xing-Gang; Spurgeon, Sarah K

    2017-09-19

    This paper addresses the robust stabilization problem for T-S fuzzy stochastic descriptor systems using an integral sliding mode control paradigm. A classical integral sliding mode control scheme and a nonparallel distributed compensation (Non-PDC) integral sliding mode control scheme are presented. It is shown that two restrictive assumptions previously adopted developing sliding mode controllers for Takagi-Sugeno (T-S) fuzzy stochastic systems are not required with the proposed framework. A unified framework for sliding mode control of T-S fuzzy systems is formulated. The proposed Non-PDC integral sliding mode control scheme encompasses existing schemes when the previously imposed assumptions hold. Stability of the sliding motion is analyzed and the sliding mode controller is parameterized in terms of the solutions of a set of linear matrix inequalities which facilitates design. The methodology is applied to an inverted pendulum model to validate the effectiveness of the results presented.

  14. Interference-Aware Opportunistic Dynamic Energy Saving Mechanism for Wi-Fi Enabled IoTs

    Directory of Open Access Journals (Sweden)

    Il-Gu Lee

    2017-07-01

    Full Text Available The wireless local area network (WLAN is one of the most popular wireless technologies offering connectivity today, and one of the candidates for the internet of things (IoTs. However, WLAN’s inefficiency in terms of complexity and relatively large power consumption compared with other wireless standards has been reported as a major barrier for IoTs applications. This paper proposes an interference-aware opportunistic dynamic energy saving mechanism to improve energy efficiency for Wi-Fi enabled IoTs. The proposed scheme optimizes operating clock frequencies adaptively for signal processing when the mobile station transmits packets in partial sub-channels. Evaluation results demonstrate that the proposed scheme improves energy efficiency by approximately 34%.

  15. 汽车行业何以推行ISO/TS 16949认证?%Why Promote ISO/TS 16949 Recognition in the Automobile Industry?

    Institute of Scientific and Technical Information of China (English)

    李光耀

    2007-01-01

    现在汽车企业通过ISO:9001《质量管理体系要求》,“CCC”认证也许不是什么新鲜事了,但通过ISO 14001《环境管理体系规范及使用指南》、OHSAS 18001《职业卫生与安全管理体系》和ISO/TS 16949:2002《质量管理体系汽车生产件与相关服务件的组织实施ISO 9001:2000的特殊要求》认证的汽车及零部件厂家还很少.尤其是通过ISO/TS 16949:2002认证的则更少。2006年10月8日,一汽轿车股份有限公司通过ISO/TS 16949认证现场审核;

  16. Digastric Muscle Phenotypes of the Ts65Dn Mouse Model of Down Syndrome.

    Directory of Open Access Journals (Sweden)

    Tiffany J Glass

    Full Text Available Down syndrome is frequently associated with complex difficulties in oromotor development, feeding, and swallowing. However, the muscle phenotypes underlying these deficits are unclear. We tested the hypotheses that the Ts65Dn mouse model of DS has significantly altered myosin heavy chain (MyHC isoform profiles of the muscles involved in feeding and swallowing, as well as reductions in the speed of these movements during behavioral assays. SDS-PAGE, immunofluorescence, and qRT-PCR were used to assess MyHC isoform expression in pertinent muscles, and functional feeding and swallowing performance were quantified through videofluoroscopy and mastication assays. We found that both the anterior digastric (ADG and posterior digastric (PDG muscles in 11-day old and 5-6 week old Ts65Dn groups showed significantly lower MyHC 2b protein levels than in age-matched euploid control groups. In videofluoroscopic and videotape assays used to quantify swallowing and mastication performance, 5-6 week old Ts65Dn and euploid controls showed similar swallow rates, inter-swallow intervals, and mastication rates. In analysis of adults, 10-11 week old Ts65Dn mice revealed significantly less MyHC 2b mRNA expression in the posterior digastric, but not the anterior digastric muscle as compared with euploid controls. Analysis of MyHC 2b protein levels across an adult age range (10-53 weeks of age revealed lower levels of MyHC 2b protein in the PDG of Ts65Dn than in euploids, but similar levels of MyHC 2b in the ADG. Cumulatively, these results indicate biochemical differences in some, but not all, muscles involved in swallowing and jaw movement in Ts65Dn mice that manifest early in post-natal development, and persist into adulthood. These findings suggest potential utility of this model for future investigations of the mechanisms of oromotor difficulties associated with Down syndrome.

  17. Thymidylate synthase (TS tandem repeat promoter polymorphism and susceptibility to colorectal cancer of romanian subjects

    Directory of Open Access Journals (Sweden)

    Mihai TOMA

    2010-05-01

    Full Text Available The risk of colorectal cancer (CRC is influence by polymorphisms located in the genes encoding enzymes of the folate pathway. The aim of this study was to evaluate if 2R/3R TS (rs34743033 polymorphism is involved in predisposition for colorectal in Romanian subjects. In the present case-control study, 75 sporadic CRC subjects and 60 healthy controls were genotyped by PCR method. The frequency of 3R/3R genotype was 40% in control group and 42.7% in cancer group. We found that there was no statistically significant association between the risk for CRC and 2R/3R TS polymorphism in Romanian subjects.

  18. A Solution-Based Temperature Sensor Using the Organic Compound CuTsPc

    Directory of Open Access Journals (Sweden)

    Shahino Mah Abdullah

    2014-06-01

    Full Text Available An electrochemical cell using an organic compound, copper (II phthalocyanine-tetrasulfonic acid tetrasodium salt (CuTsPc, has been fabricated and investigated as a solution-based temperature sensor. The capacitance and resistance of the ITO/CuTsPc solution/ITO chemical cell has been characterized as a function of temperature in the temperature range of 25–80 °C. A linear response with minimal hysteresis is observed. The fabricated temperature sensor has shown high consistency and sensitive response towards a specific range of temperature values.

  19. Study on NDVI-Ts space by combining LAI and evapotranspiration

    Institute of Scientific and Technical Information of China (English)

    HAN Lijuan; WANG Pengxin; YANG Hua; LIU Shaomin; WANG Jindi

    2006-01-01

    This paper focuses on interpreting the different spatial relationships between NDVI and Ts, a triangular or a trapezoid, and on analyzing transformation conditions, the physical and ecological meanings of the vegetation index-surface temperature space as well. Further, we use the Temperature-Vegetation Dryness Index (TVDI) to explain the existent meaning of a triangular space after NDVI reaches its saturated state by employing the relationships between NDVI, LAI and evapotranspiration.The specific relations between NDVI and Ts are useful for describing, validating and updating land surface models.

  20. Aleksandr Gol’ts, Armiia Rossii: 11 poteriannykh let, Moscow: Zakharov, 2004, 224 pp.

    Directory of Open Access Journals (Sweden)

    Richard F. Staar

    2004-07-01

    Full Text Available Specialist of military questions, Aleksandr Gol’ts worked for Red Star (Krasnaia Zvezda, the newspaper of the Russian Ministry of Defense, before joining various prestigious magazines such as Itogi. He is considered one of the most prominent journalist on military matters in Russia today. His book, “The Russian Army : 11 lost years”, is dedicated to military reforms in post-Soviet Russia. With his extensive knowledge of institutional realities of the military establishment, Gol’ts provides a...

  1. Xilinx通过ISO/TS 16949汽车行业标准认证

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    赛灵思公司(Xilinx)公司宣布获得汽车行业质量标准ISO/TS 16949认证,通过该ISO/TS 16949标准使赛灵思能够为整个汽车供应链提供质量和可靠性更高的电子元器件。据称赛灵思公司在此之前已经满足了其它世界级质量标准的严格要求,包括ISO9001、TL 9000和QML。

  2. ISO 9000标准与ISO/TS 16949技术规范

    Institute of Scientific and Technical Information of China (English)

    陶泳; 朱文玉

    2005-01-01

    根据ISO的报道,当前标准的变化有两个趋势,一是各类专业标准日益增多,有专业的延伸,有范围上的扩展.另一个趋势是标准的集成化或整合,即相关标准集成一个统一体.本文论述了TS 16949与ISO 9000标准的关系及贯彻TS 16949的必要性.

  3. Safety inspections - the role of TS : risks, their assessment and the role of safety systems

    CERN Document Server

    Béjar-Alonso, Isabel; CERN. Geneva. TS Department

    2008-01-01

    In 2007 the DG decided a new approach for safety at CERN. This had as consequence the creation of a new unit, the safety service provider, in the TS department. The organization and the services that this unit provides to CERN will be described and the achievements since the creation of the unit will be summarized. Some important personnel safety systems, on their side have been the responsibility of the TS Department for many years. Their importance has grown with the arrival of LHC and their complexity and impact on operation has increased. Their role as well as the importance of an appropriate regulatory framework shall be discussed.

  4. Associações entre CMMI-DEV 1.2 E ISO/TS 16949

    OpenAIRE

    Altamar Urbanetz de Araújo Albanez; Carla Cristina Amodio Estorilio

    2014-01-01

    The automotive sector is one of the most daring in terms of quality, requiring ISO/TS 16949 certification. Nevertheless, there are companies those lose their certification or develop only some improvements due to a lack of enough maturity to maintain it and gaps in continuous improvement guidelines. Whereas CMMI is one of the diagnostic methods of maturity, the aim of this work is to identify the feasibility of linking the ISO/TS 16949 with the CMMI-DEV 1.2. The method used consists in review...

  5. Fuzzy Identification Based on T-S Fuzzy Model and Its Application for SCR System

    Science.gov (United States)

    Zeng, Fanchun; Zhang, Bin; Zhang, Lu; Ji, Jinfu; Jin, Wenjing

    An improved T-S model was introduced to identify the model of SCR system. Model structure was selected by physical analyzes and mathematics tests. Three different clustering algorithms were introduced to obtain space partitions. Then, space partitions were amended by mathematics methods. At last, model parameters were identified by least square method. Train data was sampled in 1000MW coal-fired unit SCR system. T-S model of it is identified by three cluster methods. Identify results are proved effective. The merit and demerit among them are analyzed in the end.

  6. Interesting coin finds of 2006 / Mauri Kiudsoo

    Index Scriptorium Estoniae

    Kiudsoo, Mauri, 1973-

    2007-01-01

    2006. aasta huvitavamatest mündileidudest. Lisaks arheoloogilistelt kaevamistelt saadud vermingutele omandati 2006. aastal kolm mündiaaret : Alansi aare Harjumaalt, ligi poolsada araabia hõbemünti sisaldav aare Tartust ning tänu politsei kaasabile jõudsid Eestisse tagasi Ubina hõbeaadre kaevamistelt varastatud hõbemündid. Eestist leitud rooma müntidest

  7. Interesting coin finds of 2006 / Mauri Kiudsoo

    Index Scriptorium Estoniae

    Kiudsoo, Mauri, 1973-

    2007-01-01

    2006. aasta huvitavamatest mündileidudest. Lisaks arheoloogilistelt kaevamistelt saadud vermingutele omandati 2006. aastal kolm mündiaaret : Alansi aare Harjumaalt, ligi poolsada araabia hõbemünti sisaldav aare Tartust ning tänu politsei kaasabile jõudsid Eestisse tagasi Ubina hõbeaadre kaevamistelt varastatud hõbemündid. Eestist leitud rooma müntidest

  8. Interesting coin finds of 2005 / Mauri Kiudsoo

    Index Scriptorium Estoniae

    Kiudsoo, Mauri, 1973-

    2006-01-01

    2005. aasta arheoloogilistel kaevamistel avastatud müntidest väärivad eraldi märkimist nn. traatkopikad. Kõige rohkem traatkopikaid leiti Vastseliina piiskopilinnuselt. Üks traatkopikatest koosnenud aare leiti Koruste külast

  9. Jälle see "Kunstisuvi" / Rait Prääts

    Index Scriptorium Estoniae

    Prääts, Rait, 1952-

    1999-01-01

    Üldistusi alates 1995. aastast toimuvast "Kunstisuvest", "Kunstisuve" tulevikust. 1995-1998 toimunud ja 1999 toimuvad näitused. 1999. a. suvel kureerivad "Kunstisuve" näitusi Agur Kruusing, Mari Sobolev, Veerle Van Durme, Terje Ojaver, Toomas Mikk, Aleksander Bauman, Karol Kallas, Sirje Eelma, Rait Prääts

  10. Exponential Stability of Uncertain T-S Fuzzy Switched Systems with Time Delay

    Institute of Scientific and Technical Information of China (English)

    Fatima Ahmida; El Houssaine Tissir

    2013-01-01

    This paper discusses the delay-dependent exponential stability of a class of uncertain T-S fuzzy switched systems with time delay.The method is based on Lyapunov stability theorem and free weighting matrices approach.Two illustrative examples are given to demonstrate the effectiveness of the proposed method.

  11. Modernization of the VVR-TS reactor core for the increasing of the radionuclides production

    Science.gov (United States)

    Fomin, R. V.; Kolesov, V. V.; Kochnov, O. Yu

    2017-01-01

    We have studied the possibility of increasing the 99Mo and 131I production through modernization of the VVR-TS reactor core. It has been found in particular that the introducing of beryllium reflector on the core periphery can significantly increase the starting reactivity margin. This, in turn, give us possibility to create an additional channel for increasing their production.

  12. [A case of metastatic esophageal cancer responding remarkably to combination chemotherapy of TS-1 and cisplatin].

    Science.gov (United States)

    Iwase, Hiroaki; Okeya, Masayuki; Shimada, Masaaki; Tsuzuki, Tomoyuki; Nakarai, Keiko; Kaida, Shogo; Doi, Reiko

    2004-05-01

    A 51-year-old male patient with esophageal cancer and cervical, thoracic and celiac artery lymph node metastases was treated by combination chemotherapy of TS-1 and cisplatin. TS-1 (80 mg/m2/day) was administered for 14 days followed by 14 days rest as 1 course. Cisplatin (70 mg/m2/day) was administered in 24-hour continuous intravenous infusion at day 8 after the start of TS-1. Before treatment, the tumor marker, CEA showed 27,060 ng/ml. After 5 courses of chemotherapy, endoscopy revealed that the primary tumor had disappeared and no cancer cells were detected by endoscopic biopsy. Chest and abdominal CT scan also showed almost total disappearance of the lymph nodes metastases. CEA decreased to 710 ng/ml. No high-grade toxicities (WHO grade 3 or 4) were seen during the chemotherapy. He is now very well. This TS-1/cisplatin chemotherapy regimen might be a useful treatment for metastatic esophageal cancer.

  13. H(infinity) output tracking control for nonlinear systems via T-S fuzzy model approach.

    Science.gov (United States)

    Lin, Chong; Wang, Qing-Guo; Lee, Tong Heng

    2006-04-01

    This paper studies the problem of H(infinity) output tracking control for nonlinear time-delay systems using Takagi-Sugeno (T-S) fuzzy model approach. An LMI-based design method is proposed for achieving the output tracking purpose. Illustrative examples are given to show the effectiveness of the present results.

  14. Commercial Test of Multi-functional Desulfurizing Agent TS-01 for Gasoline in FCC Process

    Institute of Scientific and Technical Information of China (English)

    Cai Zhi; Wu Yingjian; Yu Weisheng

    2003-01-01

    Experimental use of multi-functional desulfurizing agent TS-01 for FCC gasoline in the FCC unitof SINOPEC Jiujiang Company shows that the multi-functional desulfurizing agent can effectivelyremove various kinds of sulfur in FCC gasoline and diesel fuel and fulfill passivation on heavy metals.

  15. Tsheloveku nuzhen drugoi tshelovek / Jevgeni Tsõmbal ; interv. Nikolai Hrustaljov

    Index Scriptorium Estoniae

    Tsõmbal, Jevgeni

    2008-01-01

    Režissöör Jevgeni Tsõmbal räägib intervjuus oma tööst, Aleksandr Kaidanovskist, kellele ta pühendas dokumentaalfilmi "Snõ Stalkera", Andrei Tarkovskist ja tema filmidest "Stalker" ja "Solaris"

  16. Axonal abnormalities in cerebellar Purkinje cells of the Ts65Dn mouse.

    Science.gov (United States)

    Necchi, Daniela; Lomoio, Selene; Scherini, Elda

    2008-10-31

    Ts65Dn mice are a genetic model for Down syndrome. Among others, these mice have cerebellar pathology features which parallel those seen in Down syndrome patients. Both individuals with Down syndrome and Ts65Dn mice have reduced cerebellar volume and numbers of granule and Purkinje cells. In this report, we describe morphological abnormalities of axons of Purkinje cells in the cerebellum of Ts65Dn mice, by using anti-calbindin immunocytochemistry. A consistent number of Purkinje cells shows axons bearing giant varicosities along their transit through the granular layer. The cerebellar arbor vitae made by fasciculated Purkinje cell axons has a patchy appearance, some tracks being devoid of calbindin staining. The infraganglionic plexus, formed by recurrent collaterals of Purkinje cell axons, has enormously increased density, which is evidence for a compensatory reaction to degeneration of distal segments of axons. These alterations are accompanied by strong glial reaction as evidenced by GFAP immunocytochemistry. Moreover, the alterations are more consistent in the anterior lobules of the vermis and intermediate cortex. The axonal pathology of Purkinje cells may explain the impairment in cerebellar functions observed in Ts65Dn mice at the adulthood.

  17. Guidelines : the do's, don'ts and don't knows of feedback for clinical education

    NARCIS (Netherlands)

    Lefroy, Janet; Watling, Chris; Teunissen, Pim W; Brand, Paul

    2015-01-01

    INTRODUCTION: The guidelines offered in this paper aim to amalgamate the literature on formative feedback into practical Do's, Don'ts and Don't Knows for individual clinical supervisors and for the institutions that support clinical learning. METHODS: The authors built consensus by an iterative proc

  18. Deep-HiTS: Rotation Invariant Convolutional Neural Network for Transient Detection

    Science.gov (United States)

    Cabrera-Vives, Guillermo; Reyes, Ignacio; Förster, Francisco; Estévez, Pablo A.; Maureira, Juan-Carlos

    2017-02-01

    We introduce Deep-HiTS, a rotation-invariant convolutional neural network (CNN) model for classifying images of transient candidates into artifacts or real sources for the High cadence Transient Survey (HiTS). CNNs have the advantage of learning the features automatically from the data while achieving high performance. We compare our CNN model against a feature engineering approach using random forests (RFs). We show that our CNN significantly outperforms the RF model, reducing the error by almost half. Furthermore, for a fixed number of approximately 2000 allowed false transient candidates per night, we are able to reduce the misclassified real transients by approximately one-fifth. To the best of our knowledge, this is the first time CNNs have been used to detect astronomical transient events. Our approach will be very useful when processing images from next generation instruments such as the Large Synoptic Survey Telescope. We have made all our code and data available to the community for the sake of allowing further developments and comparisons at https://github.com/guille-c/Deep-HiTS. Deep-HiTS is licensed under the terms of the GNU General Public License v3.0.

  19. Eastern equatorial Pacific Ocean T-S variations with El Nino

    Science.gov (United States)

    Wang, O.; Fukumori, I.; Lee, T.; Johnson, G. C.

    2004-01-01

    Temperature-Salinity (T-S) relationship variability in the pycnocline of the eastern equatorial Pacific Ocean (NINO3 region, 5 degrees S ??degrees N, 150 degrees W ?? degrees W) over the last two decades is investigated using observational data and model simulation.

  20. OPERATOR AND MATRIX REPRESENTATION FOR THE GENERALIZED INVERSE A(2)T,S

    Institute of Scientific and Technical Information of China (English)

    陈永林

    2001-01-01

    This paper presents the matrix representation for extension of inverse of restriction of a linear operator to a subspace, on the basis of which we establish useful representations in operator and matrix form for the generalized inverse A(2)T,S and give some of their applications.

  1. 75 FR 67705 - Office of Postsecondary Education; Overview Information; Talent Search (TS) Program; Notice...

    Science.gov (United States)

    2010-11-03

    ... rigorous secondary school program of study, postsecondary education enrollment, and postsecondary degree... individuals with potential for education at the postsecondary level and encourage them to complete secondary school and undertake a program of postsecondary education. TS projects publicize the availability of,...

  2. Cloning and Characterization of EF-Tu and EF-Ts from Pseudomonas aeruginosa

    Directory of Open Access Journals (Sweden)

    Stephanie O. Palmer

    2013-01-01

    Full Text Available We have cloned genes encoding elongation factors EF-Tu and EF-Ts from Pseudomonas aeruginosa and expressed and purified the proteins to greater than 95% homogeneity. Sequence analysis indicated that P. aeruginosa EF-Tu and EF-Ts are 84% and 55% identical to E. coli counterparts, respectively. P. aeruginosa EF-Tu was active when assayed in GDP exchange assays. Kinetic parameters for the interaction of EF-Tu with GDP in the absence of EF-Ts were observed to be = 33 μM, = 0.003 s−1, and the specificity constant was  s−1 μM−1. In the presence of EF-Ts, these values were shifted to = 2 μM, = 0.005 s−1, and the specificity constant was  s−1 μM−1. The equilibrium dissociation constants governing the binding of EF-Tu to GDP ( were 30–75 nM and to GTP ( were 125–200 nM. EF-Ts stimulated the exchange of GDP by EF-Tu 10-fold. P. aeruginosa EF-Tu was active in forming a ternary complex with GTP and aminoacylated tRNA and was functional in poly(U-dependent binding of Phe-tRNAPhe at the A-site of P. aeruginosa ribosomes. P. aeruginosa EF-Tu was active in poly(U-programmed polyphenylalanine protein synthesis system composed of all P. aeruginosa components.

  3. TS Gene Polymorphisms Are Not Good Markers of Response to 5-FU Therapy in Stage III Colon Cancer Patients

    Directory of Open Access Journals (Sweden)

    A. Fariña-Sarasqueta

    2010-01-01

    Full Text Available Aim: Although the predictive and prognostic value of thymidylate synthase (TS expression and gene polymorphism in colon cancer has been widely studied, the results are inconclusive probably because of methodological differences. With this study, we aimed to elucidate the role of TS gene polymorphisms genotyping in therapy response in stage III colon carcinoma patients treated with 5-FU adjuvant chemotherapy.

  4. Endocannabinoids blunt the augmentation of synaptic transmission by serotonin 2A receptors in the nucleus tractus solitarii (nTS).

    Science.gov (United States)

    Austgen, James R; Kline, David D

    2013-11-06

    Serotonin (5-Hydroxytryptamine, 5-HT) and the 5-HT2 receptor modulate cardiovascular and autonomic function in part through actions in the nTS, the primary termination and integration point for cardiorespiratory afferents in the brainstem. In other brain regions, 5-HT2 receptors (5-HT2R) modify synaptic transmission directly, as well as through 5-HT2AR-induced endocannabinoid release. This study examined the role of 5-HT2AR as well as their interaction with endocannabinoids on neurotransmission in the nucleus tractus solitarii (nTS). Excitatory postsynaptic currents (EPSCs) in monosynaptic nTS neurons were recorded in the horizontal brainstem slice during activation and blockade of 5-HT2ARs. 5-HT2AR activation augmented solitary tract (TS) evoked EPSC amplitude whereas 5-HT2AR blockade depressed TS-EPSC amplitude at low and high TS stimulation rates. The 5-HT2AR-induced increase in neurotransmission was reduced by endocannabinoid receptor block and increased endogenous endocannabinoids in the synaptic cleft during high frequency, but not low, TS stimulation. Endocannabinoids did not tonically modify EPSCs. These data suggest 5-HT acting through the 5-HT2AR is an excitatory neuromodulator in the nTS and its effects are modulated by the endocannabinoid system.

  5. "Cremaster' tsükkel" : Matthew Barney avastusretk kunsti ja filmikunsti vahealal / Miriam Dagan ; tõlk. Epp Aareleid

    Index Scriptorium Estoniae

    Dagan, Miriam

    2007-01-01

    Ameerika kunstniku ja režissööri kunstnikufilmidest "Cremaster' tsükkel" (1994-2002). Viie tsükli põhisündmusest. Viienda filmi rekvisiitor oli Meeli Salumäe, Kostabi Maailma assistent New Yorgis

  6. "Cremaster' tsükkel" : Matthew Barney avastusretk kunsti ja filmikunsti vahealal / Miriam Dagan ; tõlk. Epp Aareleid

    Index Scriptorium Estoniae

    Dagan, Miriam

    2007-01-01

    Ameerika kunstniku ja režissööri kunstnikufilmidest "Cremaster' tsükkel" (1994-2002). Viie tsükli põhisündmusest. Viienda filmi rekvisiitor oli Meeli Salumäe, Kostabi Maailma assistent New Yorgis

  7. Function and structure in phage Qbeta RNA replicase. Association of EF-Tu-Ts with the other enzyme subunits

    DEFF Research Database (Denmark)

    Blumenthal, T; Young, R A; Brown, S

    1976-01-01

    Qbeta replicase is a complex of four nonidentical subunits readily dissociable into two subcomplexes: 30 S ribosomal protein S1 and the phage-coded polypeptide (Subunits I + II) and protein synthesis elongation factors EF-Tu and EF-Ts (Subunits III + IV). The affinity of the two subcomplexes...... of EF-Tu-Ts from the other enzyme subunits: whereas free EF-Tu-Ts binds GDP independently of salt concentration, this binding by Qbeta replicase is sensitive to high ionic strength and remains so in the presence of Qbeta RNA. Furthermore, RNA does not allow the release of EF-Ts from EF-Tu by GTP...... as measured by sensitivity of EF-Ts activity to N-ethylmaleimide....

  8. Research of robust adaptive trajectory linearization control based on T-S fuzzy system

    Institute of Scientific and Technical Information of China (English)

    Jiang Changsheng; Zhang Chunyu; Zhu Liang

    2008-01-01

    A robust adaptive trajectory linearization control (RATLC) algorithm for a class of nonlinear systems with uncertainty and disturbance based on the T-S fuzzy system is presented. The unknown disturbance and uncertainty are estimated by the T-S fuzzy system, and a robust adaptive control law is designed by the Lyapunov theory. Irrespective of whether the dimensions of the system and the rules of the fuzzy system are large or small, there is only one parameter adjusting on line. Uniformly ultimately boundedness of all signals of the composite closed-loop system are proved by theory analysis. Finally, a numerical example is studied based on the proposed method. The simulation results demonstrate the effectiveness and robustness of the control scheme.

  9. Repair activities on the LHC cryogenic distribution line in charge of TS/MME

    CERN Document Server

    Atieh, S; CERN. Geneva. TS Department

    2005-01-01

    The Cryogenic Distribution Line (QRL), running inside the machine tunnel parallel to the regular lattice of superconducting quadrupole and dipole magnets of LHC, transports the refrigeration power produced by the refrigerators over long distances. With a total length of about 25.8 km, QRL consists of a modular set-up of pipe and Service Modules (SM), Vacuum Barriers (VB), Fixed Points (FP), steps and elbows. TS department was charged to replace non-conform sliding tables included in the Cryogenic Distribution Line QRL. For this repair work, based on technologically advanced methods, TS/MME imposed a high level of quality assurance and follow-up for mechanical repair works as well as for the metrological measurements carried out which an innovative polyarticulated arm, a portable measuring device, and leak testing by argon.

  10. 参与ISO/TS 16949培训和咨询后的随想

    Institute of Scientific and Technical Information of China (English)

    张俊臣

    2007-01-01

    1问题的提出 贯ISO/TS 16949是一股大潮。由于贯ISO/TS 16949需要相当多的知识,这些知识不可能短时间的快速培训,一个人就能都掌握。因而有的公司和某些大师走“捷径”抄录一些别人的文件和作法。由于未弄懂确切道理、原理,许多文件,大师自己不懂也不知如何去做;更有甚者讲:“错了也按我说的去做。”

  11. 风神公司通过TS 16949认证

    Institute of Scientific and Technical Information of China (English)

    谢智保

    2005-01-01

    风神轮胎股份有限公司最近顺利通过了德国莱茵公司ISO/TS 16949:2002审核,审核结论认为该公司三标整合一体化管理文件运行有效,符合ISO/TS16949:2002审核认证证书推荐注册条件。这就大大推进了该公司IS0/,IS16949:2002、GB/T24001、GB/T28001三标整合一体化管理工作。

  12. Reliable filtering with strict dissipativity for T-S fuzzy time-delay systems.

    Science.gov (United States)

    Su, Xiaojie; Shi, Peng; Wu, Ligang; Basin, Michael V

    2014-12-01

    In this paper, the problem of reliable filter design with strict dissipativity has been investigated for a class of discrete-time T-S fuzzy time-delay systems. Our attention is focused on the design of a reliable filter to ensure a strictly dissipative performance for the filtering error system. Based on the reciprocally convex approach, firstly, a sufficient condition of reliable dissipativity analysis is proposed for T-S fuzzy systems with time-varying delays and sensor failures. Then, a reliable filter with strict dissipativity is designed by solving a convex optimization problem, which can be efficiently solved by standard numerical algorithms. Finally, numerical examples are provided to illustrate the effectiveness of the developed techniques.

  13. Quality Control of ARGO Data Based on Climatological T-S Models

    Institute of Scientific and Technical Information of China (English)

    纪风颖; 林绍花

    2004-01-01

    By implementing the ARGO program, a large number of T-S profiles can be observed in the world ocean. However, it is very difficult to examine changes of the sensitivity of the sensors equipped at the ARGO floats, because it is difficult to understand their condition in the sea and the reliability of the data. Quality control must be done in order to avoid the wrong conclusion deduced from the wrong data.One of the realistic methods for quality control of the ARGO data is the comparison with the local climatology. High quality climatological T-S models in northwest Pacific have been built based on the Nansen bottle data and CTD data for the quality control in NMDIS. The models are used to check the ARGO data in this area and have got good result.

  14. Hybrid vehicle turbine engine technology support (HVTE-TS) project. 1995--1996 annual report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    This report presents a summary of technical work accomplished on the Hybrid Vehicle Turbine Engine--Technology Support (HVTE-TS) Project during calendar years 1995 and 1996. Work was performed under an initial National Aeronautics and Space Administration (NASA) contract DEN3-336. As of September 1996 the contract administration was transferred to the US Department of Energy (DoE) Chicago Operations Office, and renumbered as DE-AC02-96EE50553. The purpose of the HVTE-TS program is to develop gas turbine engine technology in support of DoE and automotive industry programs exploring the use of gas turbine generator sets in hybrid-electric automotive propulsion systems. The program focus is directed to the development of four key technologies to be applied to advanced turbogenerators for hybrid vehicles: Structural ceramic materials and processes; Low emissions combustion systems; Regenerators and seals systems; and Insulation systems and processes. 60 figs., 9 tabs.

  15. Predictive functional control based on fuzzy T-S model for HVAC systems temperature control

    Institute of Scientific and Technical Information of China (English)

    Hongli L(U); Lei JIA; Shulan KONG; Zhaosheng ZHANG

    2007-01-01

    In heating,ventilating and air-conditioning(HVAC)systems,there exist severe nonlinearity,time-varying nature,disturbances and uncertainties.A new predictive functional control based on Takagi-Sugeno(T-S)fuzzy model was proposed to control HVAC systems.The T-S fuzzy model of stabilized controlled process was obtained using the least squares method,then on the basis of global linear predictive model from T-S fuzzy model,the process was controlled by the predictive functional controller.Especially the feedback regulation part was developed to compensate uncertainties of fuzzy predictive model.Finally simulation test results in HVAC systems control applications showed that the proposed fuzzy model predictive functional control improves tracking effect and robustness.Compared with the conventional PID controller,this control strategy has the advantages of less overshoot and shorter setting time,etc.

  16. NONLINEAR EVOLUTION ANALYSIS OF T-S DISTURBANCE WAVE AT FINITE AMPLITUDE IN NONPARALLEL BOUNDARY LAYERS

    Institute of Scientific and Technical Information of China (English)

    唐登斌; 夏浩

    2002-01-01

    The nonlinear evolution problem in nonparallel boundary layer stability was studied. The relative parabolized stability equations of nonlinear nonparallel boundary layer were derived. The developed numerical method, which is very effective, was used to study the nonlinear evolution of T-S disturbance wave at finite amplitudes. Solving nonlinear equations of different modes by using predictor-corrector and iterative approach, which is uncoupled between modes, improving computational accuracy by using high order compact differential scheme, satisfying normalization condition, determining tables of nonlinear terms at different modes, and implementing stably the spatial marching, were included in this method. With different initial amplitudes, the nonlinear evolution of T-S wave was studied. The nonlinear nonparallel results of examples compare with data of direct numerical simulations (DNS) using full Navier- Stokes equations.

  17. Role of lysine and tryptophan residues in the biological activity of toxin VII (Ts gamma) from the scorpion Tityus serrulatus.

    Science.gov (United States)

    Hassani, O; Mansuelle, P; Cestèle, S; Bourdeaux, M; Rochat, H; Sampieri, F

    1999-02-01

    Toxin VII (TsVII), also known as Ts gamma, is the most potent neurotoxin in the venom of the Brazilian scorpion Tityus serrulatus. It has been purified to homogeneity using a new fast and efficient method. Chemical modification of TsVII with the tryptophan-specific reagent o-nitrophenylsulfenyl chloride yielded three modified derivatives (residues Trp39, Trp50 and Trp54). Acetylation of TsVII mostly generated the monoacetylated Lys12 derivative. No side reactions were detected, as indicated by endoproteinase Lys-C peptide mapping, Edman degradation and electrospray mass spectrometry. Circular dichroism and fluorimetric measurements showed that none of the chemical modifications altered the overall structure of the derivatives. The acetylation of Lys12 or the sulfenylation of Trp39 or Trp54 led to a loss of both toxicity in mice and apparent binding affinity for rat brain and cockroach synaptosomal preparations. Sulfenylation of Trp50, however, moderately affected the toxicity of TsVII in mice and had almost no effect on its binding properties. A 3-dimensional model of TsVII was constructed by homology modeling. It suggests that the most reactive residues (Lys12 and Trp39 and Trp54) are all important in the functional disruption of neuronal sodium channels by TsVII, and are close to each other in the hydrophobic conserved region.

  18. Excitatory amino acid transporters tonically restrain nTS synaptic and neuronal activity to modulate cardiorespiratory function.

    Science.gov (United States)

    Matott, Michael P; Ruyle, Brian C; Hasser, Eileen M; Kline, David D

    2016-03-01

    The nucleus tractus solitarii (nTS) is the initial central termination site for visceral afferents and is important for modulation and integration of multiple reflexes including cardiorespiratory reflexes. Glutamate is the primary excitatory neurotransmitter in the nTS and is removed from the extracellular milieu by excitatory amino acid transporters (EAATs). The goal of this study was to elucidate the role of EAATs in the nTS on basal synaptic and neuronal function and cardiorespiratory regulation. The majority of glutamate clearance in the central nervous system is believed to be mediated by astrocytic EAAT 1 and 2. We confirmed the presence of EAAT 1 and 2 within the nTS and their colocalization with astrocytic markers. EAAT blockade withdl-threo-β-benzyloxyaspartic acid (TBOA) produced a concentration-related depolarization, increased spontaneous excitatory postsynaptic current (EPSC) frequency, and enhanced action potential discharge in nTS neurons. Solitary tract-evoked EPSCs were significantly reduced by EAAT blockade. Microinjection of TBOA into the nTS of anesthetized rats induced apneic, sympathoinhibitory, depressor, and bradycardic responses. These effects mimicked the response to microinjection of exogenous glutamate, and glutamate responses were enhanced by EAAT blockade. Together these data indicate that EAATs tonically restrain nTS excitability to modulate cardiorespiratory function.

  19. A Novel Identification Method for Generalized T-S Fuzzy Systems

    Directory of Open Access Journals (Sweden)

    Ling Huang

    2012-01-01

    Full Text Available In order to approximate any nonlinear system, not just affine nonlinear systems, generalized T-S fuzzy systems, where the control variables and the state variables, are all premise variables are introduced in the paper. Firstly, fuzzy spaces and rules were determined by using ant colony algorithm. Secondly, the state-space model parameters are identified by using genetic algorithm. The simulation results show the effectiveness of the proposed algorithm.

  20. Sliding Mode Control for Nonlinear System Based on T-S Model

    Institute of Scientific and Technical Information of China (English)

    WU Zhong-qiang

    2002-01-01

    Using T-S model as an approximation for nonlinear system, the nonlinear system has been fuzzy into local linear model. The variable structure controller designed by using Lyapunov theory insures the stability of system. The sliding mode controller is designed by using unit vector style, and it suit the uncertain elements satisfying matching condition or do not satisfy matching condition. The effect of the scheme has been tasted with a simulation of an inverted pendulum.

  1. T-S criticality of black holes with power Maxwell invariant source

    Science.gov (United States)

    Lin, Ze-Tao; Li, Gu-Qiang; Long, Kun; He, Fang; Mo, Jie-Xiong

    2017-09-01

    In this paper, we show that black holes with PMI source exhibit the T-S criticality and derive the relevant critical physical quantities analytically. The values of critical quantities for the case s≠1 vary from those for the case s=1, showing the effect of PMI field on the critical phenomena of black holes. When qPMI field does not affect the Maxwell equal area law.

  2. Analysis of T.S Eliot’s The Waste Land

    Institute of Scientific and Technical Information of China (English)

    涂艳

    2014-01-01

    This essay put emphasis on the analysis T.S. Eliot’s The Waste Land, pointing the masterpiece can be interpreted by three-levels, the person, the society and human race. Eliot also indicated two kinds of people, the one is just secularized, and the other one is lack of faith in The Waste Land. We can analyze the feeling of protagonist is afraid to live new life, but afraid of death, the important theme is corruption of sex.

  3. Decentralized state observer scheme for uncertain time-delay T-S fuzzy interconnected systems

    Institute of Scientific and Technical Information of China (English)

    Yanxin ZHANG; Zhongsheng HOU; Xiaofan WANG

    2006-01-01

    This paper focuses on a class of T-S fuzzy interconnected systems with time delays and time-varying parameter uncertainties. Observer-based output feedback decentralized controller is designed such that the closed-loop interconnected system is asymptotically stable in the Lyapunov sense in probability for all admissible uncertainties and time delays. Sufficient conditions for robustly asymptotically stability of the systems are given in terms of a set of linear matrix inequalities (LMIs).

  4. Effects of Tobacco Smoke (TS) on Growth of Clear Cell Renal Cell Carcinoma (ccRCC)

    Science.gov (United States)

    2015-10-01

    and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position , policy...males than in females1. Tobacco smoking (TS), obesity , hypertension, and age are established risk factors for ccRCC development1. Despite the well...several papers . NDRI is able to procure tissues from patients with known status of smoking and additional information such as BMI and history of

  5. Cost effectiveness and cost utility of the noncoding blood glucose meter CONTOUR® TS

    Directory of Open Access Journals (Sweden)

    Przemyslaw Holko

    2011-02-01

    Full Text Available Przemyslaw Holko, Pawal KawalecHTA Centre, Kraków, PolandAims: This study assessed the cost efficacy and cost utility of the automatic blood glucose meter CONTOUR® TS from the public payer (National Health Fund [NHF] and payer (patient and NHF perspectives over a 26-year analysis horizon.Methods: Clinical effectiveness data were obtained from prior clinical studies of automatic versus manually coded blood glucose meters. Cost data were obtained from the NHF. The probability of procedure use related to diabetic complications was obtained from four medical centers in Poland. The incremental cost-effectiveness ratio related to 1 life year gained and the incremental cost-utility ratio related to 1 quality-adjusted life year gained were calculated.Results: Assuming co-funding from public funds, introduction of the CONTOUR® TS is associated with savings of Polish złoty (PLN 31,846.19 (€8916.93 and PLN 113,018.19 (€31,645.09 per life year gained from the payer and public payer perspectives, respectively. Cost utility analyses showed that the CONTOUR® TS is associated with savings of PLN 40,465.59 (€11,330.37 and PLN 11,434.82 (€3201.75 per quality-adjusted life year gained from the payer and the public payer perspectives, respectively.Conclusion: The CONTOUR® TS appears superior to manually coded meters available in Poland both from the payer and the public payer perspectives and may represent an improved strategy for glycemic control.Keywords: blood glucose self monitoring, costs and cost analysis, health care costs, diabetes mellitus, diabetes complications 

  6. PRODUCTIVE BEHAVIOR OF A LOT OF HENS POSITION vaccinated with strain of Mycoplasma gallisepticum ts11

    OpenAIRE

    Sánchez I., Roxana; Práctica privada; Icochea D., Eliana; Laboratorio de Patología Aviar, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima-Perú.; Ramírez V., Antonio; Práctica privada; Falcón P., Néstor; Laboratorio de Medicina Veterinaria Preventiva, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima; Alba Ch., Mónica; Laboratorio de Patología Aviar, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima-Perú.

    2012-01-01

    A field study was conducted to evaluate productive parameters in layers vaccinated with the Mycoplasma gallisepticum (MG) ts11 vaccine. A total of 9,065 free mycoplasma Hy Line Brown pullets were raised on a previously detected MG positive farm. The birds were divided in two groups and placed in two separated sections in the same farm. One group was vaccinated at four weeks of age and the other remained non vaccinated. Serum plate agglutination (SPA), haemagglutination inhibition (HI) and enz...

  7. Development of High-Field ST Merging Experiment: TS-U for High Power Reconnection Heating

    Science.gov (United States)

    Ono, Y.; Koike, H.; Tanabe, H.; Himeno, S.; Ishida, S.; Kimura, K.; Kawanami, M.; Narita, M.; Takahata, Y.; Yokoyama, T.; Inomoto, M.; Cheng, C. Z.

    2016-10-01

    We are developing high-magnetic field ST merging/ reconnection experiment TS-U with Brec = 0.3-0.5T, based on our scaling law of reconnection heating energy proportional to square of the reconnecting (poloidal) magnetic field Brec. This scaling law indicates that the high-Brec ST merging will heat ions to the burning plasma regime without using any additional heating facility. Its mechanism is that the reconnection outflow accelerates mainly ions up to the poloidal Alfven speed like the Sweet-Parker model. The shock-like density pileups thermalize the accelerated ions in the down-streams in agreement with recent solar satellite observations and PIC simulation results. We already documented significant ion heating of spheromak and ST mergings up to 0.25keV in TS-3 and 1.2keV in MAST, leading us to the high-Brec merging experiment TS-U. It is noted that high-resolution (>500 channel) 2D measurements of ion and electron temperatures is being developed for the purpose of solving all acceleration and heating effects of magnetic reconnection, such as the huge outflow heating of ions in the downstream and electron heating localized at the X-point.

  8. Synaptic Vesicle Recycling Is Unaffected in the Ts65Dn Mouse Model of Down Syndrome.

    Science.gov (United States)

    Marland, Jamie R K; Smillie, Karen J; Cousin, Michael A

    2016-01-01

    Down syndrome (DS) is the most common genetic cause of intellectual disability, and arises from trisomy of human chromosome 21. Accumulating evidence from studies of both DS patient tissue and mouse models has suggested that synaptic dysfunction is a key factor in the disorder. The presence of several genes within the DS trisomy that are either directly or indirectly linked to synaptic vesicle (SV) endocytosis suggested that presynaptic dysfunction could underlie some of these synaptic defects. Therefore we determined whether SV recycling was altered in neurons from the Ts65Dn mouse, the best characterised model of DS to date. We found that SV exocytosis, the size of the SV recycling pool, clathrin-mediated endocytosis, activity-dependent bulk endocytosis and SV generation from bulk endosomes were all unaffected by the presence of the Ts65Dn trisomy. These results were obtained using battery of complementary assays employing genetically-encoded fluorescent reporters of SV cargo trafficking, and fluorescent and morphological assays of fluid-phase uptake in primary neuronal culture. The absence of presynaptic dysfunction in central nerve terminals of the Ts65Dn mouse suggests that future research should focus on the established alterations in excitatory / inhibitory balance as a potential route for future pharmacotherapy.

  9. Synaptic Vesicle Recycling Is Unaffected in the Ts65Dn Mouse Model of Down Syndrome.

    Directory of Open Access Journals (Sweden)

    Jamie R K Marland

    Full Text Available Down syndrome (DS is the most common genetic cause of intellectual disability, and arises from trisomy of human chromosome 21. Accumulating evidence from studies of both DS patient tissue and mouse models has suggested that synaptic dysfunction is a key factor in the disorder. The presence of several genes within the DS trisomy that are either directly or indirectly linked to synaptic vesicle (SV endocytosis suggested that presynaptic dysfunction could underlie some of these synaptic defects. Therefore we determined whether SV recycling was altered in neurons from the Ts65Dn mouse, the best characterised model of DS to date. We found that SV exocytosis, the size of the SV recycling pool, clathrin-mediated endocytosis, activity-dependent bulk endocytosis and SV generation from bulk endosomes were all unaffected by the presence of the Ts65Dn trisomy. These results were obtained using battery of complementary assays employing genetically-encoded fluorescent reporters of SV cargo trafficking, and fluorescent and morphological assays of fluid-phase uptake in primary neuronal culture. The absence of presynaptic dysfunction in central nerve terminals of the Ts65Dn mouse suggests that future research should focus on the established alterations in excitatory / inhibitory balance as a potential route for future pharmacotherapy.

  10. Agent Based Fuzzy T-S Multi-Model System and Its Applications

    Directory of Open Access Journals (Sweden)

    Xiaopeng Zhao

    2015-11-01

    Full Text Available Based on the basic concepts of agent and fuzzy T-S model, an agent based fuzzy T-S multi-model (ABFT-SMM system is proposed in this paper. Different from the traditional method, the parameters and the membership value of the agent can be adjusted along with the process. In this system, each agent can be described as a dynamic equation, which can be seen as the local part of the multi-model, and it can execute the task alone or collaborate with other agents to accomplish a fixed goal. It is proved in this paper that the agent based fuzzy T-S multi-model system can approximate any linear or nonlinear system at arbitrary accuracy. The applications to the benchmark problem of chaotic time series prediction, water heater system and waste heat utilizing process illustrate the viability and the efficiency of the mentioned approach. At the same time, the method can be easily used to a number of engineering fields, including identification, nonlinear control, fault diagnostics and performance analysis.

  11. 从QS-9000:1998到ISO/TS16949:2002

    Institute of Scientific and Technical Information of China (English)

    陈奕爽; 魏占魁

    2005-01-01

    当前,在我国汽车行业开展得最普遍,应用最广泛的依然是ISO 9000系列质量管理体系认证,同时也有部分企业按照QS-9000:1998,VDA6.1等质量管理体系要求等进行认证,随着ISO/TS16949:2002技术规范的问世,其将逐渐成为我国汽车行业质量管理体系认证的主流模式。本文通过对QS-9000:1998及ISO/TS16949:2002的特点对比分析,结合目前我国汽车行业认证的现状,对已经获得QS-9000:1998标准认证注册资格的企业如何按照ISO/TS 16949:2002技术规范的要求建立质量管理体系提出几点建议。

  12. Altered distribution of hippocampal interneurons in the murine Down Syndrome model Ts65Dn.

    Science.gov (United States)

    Hernández-González, Samuel; Ballestín, Raúl; López-Hidalgo, Rosa; Gilabert-Juan, Javier; Blasco-Ibáñez, José Miguel; Crespo, Carlos; Nácher, Juan; Varea, Emilio

    2015-01-01

    Down Syndrome, with an incidence of one in 800 live births, is the most common genetic alteration producing intellectual disability. We have used the Ts65Dn model, that mimics some of the alterations observed in Down Syndrome. This genetic alteration induces an imbalance between excitation and inhibition that has been suggested as responsible for the cognitive impairment present in this syndrome. The hippocampus has a crucial role in memory processing and is an important area to analyze this imbalance. In this report we have analysed, in the hippocampus of Ts65Dn mice, the expression of synaptic markers: synaptophysin, vesicular glutamate transporter-1 and isoform 67 of the glutamic acid decarboxylase; and of different subtypes of inhibitory neurons (Calbindin D-28k, parvalbumin, calretinin, NPY, CCK, VIP and somatostatin). We have observed alterations in the inhibitory neuropil in the hippocampus of Ts65Dn mice. There was an excess of inhibitory puncta and a reduction of the excitatory ones. In agreement with this observation, we have observed an increase in the number of inhibitory neurons in CA1 and CA3, mainly interneurons expressing calbindin, calretinin, NPY and VIP, whereas parvalbumin cell numbers were not affected. These alterations in the number of interneurons, but especially the alterations in the proportion of the different types, may influence the normal function of inhibitory circuits and underlie the cognitive deficits observed in DS.

  13. Le bureau d'études TS/CV/BE pour les besoins du projet LHC

    CERN Document Server

    Martel, C

    2004-01-01

    Le bureau d'études TS/CV/BE propose un appui technique personnalisé aux différentes sections du groupe TS/CV, responsables des projets liés aussi bien à la machine LHC, ses zones expérimentales, que d'autres projets associés. L'équipe, constituée historiquement et exclusivement de personnel d'entreprise extérieure, dispose d'un effectif variable, adapté à des besoins planifiés. Le choix d'utiliser les mêmes logiciels de CAO que la communauté du CERN, a limité la proportion de spécialistes au sein de l'équipe. Une méthodologie particulière a donc été mise en place pour satisfaire les demandes, tout en faisant face à l'étendue et à la complexité des installations de ventilation et de refroidissement. Des compétences externes spécialisées sont également sollicitées, au cas par cas, pour optimiser les coûts de fonctionnement.

  14. Analysis of telomerase activity based on a spired DNA tetrahedron TS primer.

    Science.gov (United States)

    Li, Yan; Wen, Yanli; Wang, Lele; Liang, Wen; Xu, Li; Ren, Shuzhen; Zou, Ziying; Zuo, Xiaolei; Fan, Chunhai; Huang, Qing; Liu, Gang; Jia, Nengqin

    2015-05-15

    The development of sensitive telomerase biosensors is hindered by the restricted accessibility of telomere strand (TS) primer and the limited enzyme reaction space, which is mainly confined by the vertical distance. In this work, we designed an electrochemical telomerase biosensor based on a spired DNA tetrahedron TS primer (STTS). By adding a rigid dsDNA spire onto the top of the DNA tetrahedron, we successfully regulated the distance between the TS primer and the surface, and thus greatly facilitated the telomerase elongation on surface. The signal-to-noise ratio was 2 times higher than TSP without the spire structure. The limit of detection was calculated to be lower than 10 HeLa cells, which is at least 2 magnitudes lower than other surface extension-based electrochemical telomerase sensors without amplification. The practicability of STTS sensor was also demonstrated by analysing various other cell lines including cancer cells, stem cells of high telomerase activity and somatic cells of low telomerase activity.

  15. 如何理解ISO/TS 16949中的零缺陷%How Understands in ISO/TS 16949 the Zero Flaw

    Institute of Scientific and Technical Information of China (English)

    朱绥东; 李顺泉

    2007-01-01

    ISO/TS16949:2002《质量管理体系汽车生产和有关服务的部分组织应用ISO9001:2000的特殊要求》对应的国家标准是GB/T18305-2003《质理管理体系汽车生产件及相关服务件组织应用GB/T19001--2000的特别要求》,该标准7.1.2规定:“计数型抽样、接收水平应是零缺陷”。

  16. ERCC1 and TS Expression as Prognostic and Predictive Biomarkers in Metastatic Colon Cancer.

    Directory of Open Access Journals (Sweden)

    Michel B Choueiri

    Full Text Available In patients with metastatic colon cancer, response to first line chemotherapy is a strong predictor of overall survival (OS. Currently, oncologists lack diagnostic tests to determine which chemotherapy regimen offers the greatest chance for response in an individual patient. Here we present the results of gene expression analysis for two genes, ERCC1 and TS, measured with the commercially available ResponseDX: Colon assay (Response Genetics, Los Angeles, CA in 41 patients with de novo metastatic colon cancer diagnosed between July 2008 and August 2013 at the University of California, San Diego. In addition ERCC1 and TS expression levels as determined by RNAseq and survival data for patients in TCGA were downloaded from the TCGA data portal. We found that patients with low expression of ERCC1 (n = 33 had significantly longer median OS (36.0 vs. 10.1 mo, HR 0.29, 95% CI .095 to .84, log-rank p = 9.0x10-6 and median time to treatment to failure (TTF following first line chemotherapy (14.1 vs. 2.4 mo, HR 0.17, 95% CI 0.048 to 0.58, log-rank p = 5.3x10-4 relative to those with high expression (n = 4. After accounting for the covariates age, sex, tumor grade and ECOG performance status in a Cox proportional hazard model the association of low ERCC1 with longer OS (HR 0.18, 95% CI 0.14 to 0.26, p = 0.0448 and TTF (HR 0.16, 95% CI 0.14 to 0.21, p = 0.0053 remained significant. Patients with low TS expression (n = 29 had significantly longer median OS (36.0 vs. 14.8 mo, HR 0.25, 95% CI 0.074 to 0.82, log-rank p = 0.022 relative to those with high expression (n = 12. The combined low expression of ERCC1/TS was predictive of response in patients treated with FOLFOX (40% vs. 91%, RR 2.3, Fisher's exact test p = 0.03, n = 27, but not with FOLFIRI (71% vs. 71%, RR 1.0, Fisher's exact test p = 1, n = 14. Overall, these findings suggest that measurement of ERCC1 and TS expression has potential clinical utility in managing patients with metastatic colorectal

  17. On the Different Representation of Affricate [ts] in English and Chinese%浅议破擦音[ts]在英汉两种语言中的不同表现

    Institute of Scientific and Technical Information of China (English)

    郑程心

    2014-01-01

    英语和汉语都存在破擦音[ts],但这一相似性并没有带给以英语为母语的汉语学习者正向迁移。在以汉语为二语的教学中,学习者对汉语[ts]的习得过程显现出一定的困难。该文通过分析[ts]在汉语和英语中的音系表现来解释这一现象,并得出结论:在语音和听觉感知上相同的两个音,其音系结构可能不同。%Affricate [ts] exists in both English and Chinese. However, this similarity fails to bring positive transfer to Mandarin learners whose mother tongue is English. In teaching Chinese as a second language, difficulties appear in learners’ acquisition of [ts]. Conclusion from the analysis of the phonological representation of [ts] in Chinese and English shows that segments with same phonetic sound and acoustic perception may have different phonological structure.

  18. Enhancement by Nalidixic Acid of the Thermal Susceptibility of the Ts-7 Mutant of Escherichia Coli TAU-Bar

    Science.gov (United States)

    Nishida, Mikio; Mishima, Yukio; Kawada, Jun; Yielding, K. Lemone

    1975-01-01

    Nadilidixic acid at 5 × 10−6 M produced a substantial increase in thermal susceptibility of Ts-7, suggesting either that the thermal and nalidixic acid targets are identical or closely interdependent. PMID:1101825

  19. Usuga tõe ja töö vabariiki / Matti Päts ; interv. Ants Sild

    Index Scriptorium Estoniae

    Päts, Matti, 1933-

    2003-01-01

    Patendiameti peadirektor Matti Päts vastab küsimustele, mis puudutavad Eesti Vabariiki selle 12. taasiseseisvumisaastal, eesti ajakirjandust, segadust ühiskonnas, kokkuhoidliku meelelaadi kadumist, insenerkonna vähest esindatust ühiskonnaelu juhtimises, maaelu

  20. 77 FR 43817 - Notice of Submission for OMB Review; Office of Postsecondary Education; Talent Search (TS) Annual...

    Science.gov (United States)

    2012-07-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION Notice of Submission for OMB Review; Office of Postsecondary Education; Talent Search (TS) Annual... Departmental review of the information collection. The Department of Education is especially interested...

  1. TsPAP1 encodes a novel plant prolyl aminopeptidase whose expression is induced in response to suboptimal growth conditions

    Energy Technology Data Exchange (ETDEWEB)

    Szawlowska, Urszula; Grabowska, Agnieszka [Department of Biochemistry, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-776 Warsaw (Poland); Zdunek-Zastocka, Edyta, E-mail: edyta_zdunek_zastocka@sggw.pl [Department of Biochemistry, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-776 Warsaw (Poland); Bielawski, Wieslaw [Department of Biochemistry, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-776 Warsaw (Poland)

    2012-03-02

    Highlights: Black-Right-Pointing-Pointer A cDNA encoding a novel plant prolyl aminopeptidase, TsPAP1, was obtained from triticale. Black-Right-Pointing-Pointer The cloned TsPAP1 cDNA is 1387 bp long and encodes a protein of 390 amino acids. Black-Right-Pointing-Pointer The deduced TsPAP1 protein revealed characteristics of the monomeric bacterial PAPs. Black-Right-Pointing-Pointer The TsPAP1 mRNA level increased under drought, salinity and in the presence of metal ions. -- Abstract: A triticale cDNA encoding a prolyl aminopeptidase (PAP) was obtained by RT-PCR and has been designated as TsPAP1. The cloned cDNA is 1387 bp long and encodes a protein of 390 amino acids with a calculated molecular mass of 43.9 kDa. The deduced TsPAP1 protein exhibits a considerable sequence identity with the biochemically characterized bacterial and fungal PAP proteins of small molecular masses ({approx}35 kDa). Moreover, the presence of conserved regions that are characteristic for bacterial monomeric PAP enzymes (the GGSWG motif, the localization of the catalytic triad residues and the segment involved in substrate binding) has also been noted. Primary structure analysis and phylogenetic analysis revealed that TsPAP1 encodes a novel plant PAP protein that is distinct from the multimeric proteins that have thus far been characterized in plants and whose counterparts have been recognized only in bacteria and fungi. A significant increase in the TsPAP1 transcript level in the shoots of triticale plants was observed under drought and saline conditions as well as in the presence of cadmium and aluminium ions in the nutrient medium. This paper is the first report describing changes in the transcript levels of any plant PAP in response to suboptimal growth conditions.

  2. Towards an estimation of water masses formation areas from SMOS-based TS diagrams

    Science.gov (United States)

    Klockmann, Marlene; Sabia, Roberto; Fernandez-Prieto, Diego; Donlon, Craig; Font, Jordi

    2014-05-01

    Temperature-Salinity (TS) diagrams emphasize the mutual variability of ocean temperature and salinity values, relating them to the corresponding density. Canonically used in oceanography, they provide a means to characterize and trace ocean water masses. In [1], a first attempt to estimate surface-layer TS diagrams based on satellite measurements has been performed, profiting from the recent availability of spaceborne salinity data. In fact, the Soil Moisture and Ocean Salinity (SMOS, [2]) and the Aquarius/SAC-D [3] satellite missions allow to study the dynamical patterns of Sea Surface Salinity (SSS) for the first time on a global scale. In [4], given SMOS and Aquarius salinity estimates, and by also using Sea Surface Temperature (SST) from the Operational Sea Surface Temperature and Sea Ice Analysis (OSTIA, [5]) effort, experimental satellite-based TS diagrams have been routinely derived for the year 2011. They have been compared with those computed from ARGO-buoys interpolated fields, referring to a customised partition of the global ocean into seven regions, according to the water masses classification of [6]. In [7], moreover, besides using TS diagrams as a diagnostic tool to evaluate the temporal variation of SST and SSS (and their corresponding density) as estimated by satellite measurements, the emphasis was on the interpretation of the geographical deviations with respect to the ARGO baseline (aiming at distinguishing between the SSS retrieval errors and the additional information contained in the satellite data with respect to ARGO). In order to relate these mismatches to identifiable oceanographic structures and processes, additional satellite datasets of ocean currents, evaporation/precipitation fluxes, and wind speed have been super-imposed. Currently, the main focus of the study deals with the exploitation of these TS diagrams as a prognostic tool to derive water masses formation areas. Firstly, following the approach described in [8], the surface

  3. Chemical Characterization of N-Linked Oligosaccharide As the Antigen Epitope Recognized by an Anti-Sperm Auto-Monoclonal Antibody, Ts4.

    Directory of Open Access Journals (Sweden)

    Hiroshi Yoshitake

    Full Text Available Ts4, an anti-sperm auto-monoclonal antibody, possesses immunoreactivity to the acrosomal region of mouse epididymal spermatozoa. In addition, the mAb shows specific immunoreactivity to reproduction-related regions such as testicular germ cells and early embryo. Our qualitative study previously showed that the antigen epitope for Ts4 contained a N-linked common oligosaccharide (OS chain on testicular glycoproteins as determined by Western blotting for testicular glycoproteins after treatment with several glycohydrolases. Since the distribution of the Ts4-epitope is unique, the OS chain in Ts4-epitope may have role(s in the reproductive process. The aim of this study was to clarify the molecular structure of the Ts4-epitope, particularly its OS moiety. Using Ts4 immunoprecipitation combined with liquid chromatography and multiple-stage mass spectrometry, the candidate carbohydrate structure in the Ts4-epitope is proposed to be N-linked fucosylated agalacto-biantennary with bisecting N-acetylglucosamine (GlcNAc or with N-acetylgalactosamine-GlcNAc motif. Further binding analyses using various lectins against the mouse testicular Ts4-immunoprecipitants revealed that Phaseolus vulgaris erythroagglutinin and Pisum sativum agglutinin showed positive staining of the bands corresponding to Ts4 reactive proteins. Moreover, the immunoreactivity of Ts4 against the testicular extract was completely abrogated after digestion with β-N-acetylglucosaminidase. These results show that the Ts4-epitope contains agalacto-biantennary N-glycan with bisecting GlcNAc carrying fucose residues.

  4. ISO/TS16949技术规范介绍

    Institute of Scientific and Technical Information of China (English)

    陶金龙

    2003-01-01

    @@ ISO/TS 16949:2002是国际汽车特别工作组(IATF)在国际标准化组织质量管理和质量保证技术委员会(ISO/TC176)的支持下,在ISO9001:2000标准基础上制定的,其目的是为汽车行业供应链提供持续改进、缺陷预防以及减少变差和浪费的质量管理体系技术规范.

  5. Dos and Don’ts for butterflies of the Habitats Directive of the European Union

    Directory of Open Access Journals (Sweden)

    Chris van Swaay

    2012-03-01

    Full Text Available Twenty-nine butterfly species are listed on the Annexes of the Habitats Directive. To assist everyone who wants or needs to take action for one of these species, we compiled an overview of the habitat requirements and ecology of each species, as well as information on their conservation status in Europe. This was taken from the recent Red List and their main biogeographical regions (taken from the first reporting on Article 17 of the Directive. Most important are the Dos and Don`ts, which summarize in a few bullet points what to do and what to avoid in order to protect and conserve these butterflies and their habitats.

  6. Development of moving target detection algorithm using ADSP TS201 DSP Processor

    Directory of Open Access Journals (Sweden)

    Babu rao Kodavati

    2010-08-01

    Full Text Available This paper presents detect the presence of a target within a specified range(2 to 30m. The present work generally relates to a radar system and more particularly, to improve range resolution (3 m and minimum detection time (2 msec. Speed and accuracy are two important evaluation indicators in target detecting system. The challenges in developing the algorithm is finding the Doppler frequency and give caution signal to chief at an optimum instant of time to cause target kill. Time management serves to maintain a priority queue of all the tasks. In this work we have taken up issue of developing an algorithm using ADSP TS 201 DSP Processor.

  7. On the Cause of Eastern Equatorial Pacific Ocean T-S Variations Associated with El Nino

    Science.gov (United States)

    Wang, Ou; Fukumori, Ichiro; Lee, Tong; Cheng, Benny

    2004-01-01

    The nature of observed variations in temperature-salinity (T-S) relationship between El Nino and non-El Nino years in the pycnocline of the eastern equatorial Pacific Ocean (NINO3 region, 5(deg)S-5(deg)N, 150(deg)W-90(deg)W) is investigated using an ocean general circulation model. The origin of the subject water mass is identified using the adjoint of a simulated passive tracer. The higher salinity during El Nino is attributed to larger convergence of saltier water from the Southern Hemisphere and smaller convergence of fresher water from the Northern Hemisphere.

  8. Alignment of CT-PPS detectors in 2016, before TS2

    CERN Document Server

    Kaspar, J

    2017-01-01

    This note presents the first alignment of the CMS-TOTEM Precision Proton Spectrometer (CT-PPS) using the data from before Technical Stop 2 (TS2), 2016. This new procedure involves two stages. In the first one, data from a special calibration fill are used. In this fill, both horizontal and vertical Roman Pots (RPs) were inserted very close to the beam. In the second stage, hit distributions from physics fills (with only horizontal RPs inserted) are matched to the previously aligned reference from the calibration fill. The alignment and optics calibration is verified by reconstructing consistent $\\xi$ spectra from different RPs and LHC fills.

  9. Synthesis of mesoporous TS-1 using a hybrid SiO{sub 2}–TiO{sub 2} xerogel for catalytic oxidative desulfurization

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Seung-Tae [Department of Chemical Engineering, Inha University, Incheon 402-751 (Korea, Republic of); Jeong, Kwang-Eun; Jeong, Soon-Yong [Research Center for Green Catalysis, Division of Green Chemistry and Engineering Research, Korea Research Institute of Chemical Technology, P.O. Box 107, 141 Gajeong-ro, Yuseong, Daejeon 305-600 (Korea, Republic of); Ahn, Wha-Seung, E-mail: whasahn@inha.ac.kr [Department of Chemical Engineering, Inha University, Incheon 402-751 (Korea, Republic of)

    2012-12-15

    Graphical abstract: Display Omitted Highlights: ► Meso-TS-1 catalyst was synthesized using a SiO{sub 2}–TiO{sub 2} xerogel with an organosilane precursor. ► Hierarchical pore structure was confirmed by characterization of the materials. ► Catalytic activity was tested using oxidative desulfurization of the model sulfur compounds. ► Meso-TS-1 demonstrated significantly improved catalytic activity than TS-1. -- Abstract: Mesoporous TS-1 (M-TS-1) was synthesized using a hybrid SiO{sub 2}–TiO{sub 2} xerogel combined with an organosilane precursor. Prepared samples were characterized by XRD, UV–vis spectroscopy, SEM, and N{sub 2} adsorption–desorption measurement. M-TS-1, prepared in 2 days, showed high crystallinity and the best textural properties among the samples. The N{sub 2} adsorption–desorption isotherms of M-TS-1 exhibited a hysteresis loop at pressure higher than P/P{sub 0} = 0.4, clearly indicating the existence of mesopores. M-TS-1 has significantly larger mesopore volume (0.48 cm{sup 3}/g) than that of conventional TS-1 (0.07 cm{sup 3}/g), and showed a narrow peak centered at ca. 6.3 nm. In the oxidative desulfurization reaction, M-TS-1 was more active than conventional TS-1 at the same Ti-loading; M-TS-1 produced a dibenzothiophene (DBT) conversion of 96%, whereas conventional TS-1 produced a final DBT conversion of 5.6% after a reaction time of 180 min. Oxidative desulfurization over TS-1 was influenced both by electron density and steric hindrance in the sulfur compounds tested.

  10. 氧化硫硫杆菌TS6的生长条件及其对重金属耐受性研究%Optimum growth condition of Acidithiobacillus thiooxidans TS6 and its resistance to heavy metals

    Institute of Scientific and Technical Information of China (English)

    黄峰源; 王世梅; 周立祥

    2006-01-01

    采用纯培养的方法研究了温度和介质起始pH以及重金属对嗜酸性氧化硫硫杆菌(Acidithiobacillus thiooxidans TS6)菌株生长与活性的影响.研究表明,菌株TS6的最适生长温度为28℃,最适起始生长pH范围为2.0~6.0.在上述条件下,TS6旺盛生长,表现出氧化硫能力最强.通过检测TS6对几种重金属(Cr3+、Cu2+、Zn2+、Ni2+)的耐受性,结果发现TS6对上述重金属均有较强的耐受性,至少可耐受Cr3+、Cu2+、Zn2+、Ni2+的浓度分别达1500、400、1000和250mg·L-1.在相同的浓度下,不同重金属对TS6生长产酸作用的影响由小到大依次为Cr3+、Zn2+、Cu2+、Ni2+.随着TS6菌株驯化时间的延长,它们对重金属的耐受性可望得到进一步的增强,完全满足对各种污水污泥进行生物淋滤处理的条件.

  11. The mouse model of Down syndrome Ts65Dn presents visual deficits as assessed by pattern visual evoked potentials.

    Science.gov (United States)

    Scott-McKean, Jonah Jacob; Chang, Bo; Hurd, Ronald E; Nusinowitz, Steven; Schmidt, Cecilia; Davisson, Muriel T; Costa, Alberto C S

    2010-06-01

    The Ts65Dn mouse is the most complete widely available animal model of Down syndrome (DS). Quantitative information was generated about visual function in the Ts65Dn mouse by investigating their visual capabilities by means of electroretinography (ERG) and patterned visual evoked potentials (pVEPs). pVEPs were recorded directly from specific regions of the binocular visual cortex of anesthetized mice in response to horizontal sinusoidal gratings of different spatial frequency, contrast, and luminance generated by a specialized video card and presented on a 21-in. computer display suitably linearized by gamma correction. ERG assessments indicated no significant deficit in retinal physiology in Ts65Dn mice compared with euploid control mice. The Ts65Dn mice were found to exhibit deficits in luminance threshold, spatial resolution, and contrast threshold, compared with the euploid control mice. The behavioral counterparts of these parameters are luminance sensitivity, visual acuity, and the inverse of contrast sensitivity, respectively. DS includes various phenotypes associated with the visual system, including deficits in visual acuity, accommodation, and contrast sensitivity. The present study provides electrophysiological evidence of visual deficits in Ts65Dn mice that are similar to those reported in persons with DS. These findings strengthen the role of the Ts65Dn mouse as a model for DS. Also, given the historical assumption of integrity of the visual system in most behavioral assessments of Ts65Dn mice, such as the hidden-platform component of the Morris water maze, the visual deficits described herein may represent a significant confounding factor in the interpretation of results from such experiments.

  12. The High Cadence Transient Survey (HiTS) - I. Survey design and supernova shock breakout constraints

    CERN Document Server

    Förster, Francisco; Martín, Jaime San; Hamuy, Mario; Martínez, Jorge; Huijse, Pablo; Cabrera, Guillermo; Galbany, Lluís; de Jaeger, Thomas; González-Gaitán, Santiago; Anderson, Joseph P; Kuncarayakti, Hanindyo; Pignata, Giuliano; Bufano, Filomena; Littín, Jorge; Olivares, Felipe; Medina, Gustavo; Smith, R Chris; Vivas, A Katherina; Estévez, Pablo A; Muñoz, Ricardo; Vera, Eduardo

    2016-01-01

    We present the first results of the High cadence Transient Survey (HiTS), a survey whose objective is to detect and follow up optical transients with characteristic timescales from hours to days, especially the earliest hours of supernova (SN) explosions. HiTS uses the Dark Energy Camera (DECam) and a custom made pipeline for image subtraction, candidate filtering and candidate visualization, which runs in real-time to be able to react rapidly to the new transients. We discuss the survey design, the technical challenges associated with the real-time analysis of these large volumes of data and our first results. In our 2013, 2014 and 2015 campaigns we have detected more than 120 young SN candidates, but we did not find a clear signature from the short-lived SN shock breakouts (SBOs) originating after the core collapse of red supergiant stars, which was the initial science aim of this survey. Using the empirical distribution of limiting-magnitudes from our observational campaigns we measured the expected recove...

  13. BiGGEsTS: integrated environment for biclustering analysis of time series gene expression data.

    Science.gov (United States)

    Gonçalves, Joana P; Madeira, Sara C; Oliveira, Arlindo L

    2009-07-07

    The ability to monitor changes in expression patterns over time, and to observe the emergence of coherent temporal responses using expression time series, is critical to advance our understanding of complex biological processes. Biclustering has been recognized as an effective method for discovering local temporal expression patterns and unraveling potential regulatory mechanisms. The general biclustering problem is NP-hard. In the case of time series this problem is tractable, and efficient algorithms can be used. However, there is still a need for specialized applications able to take advantage of the temporal properties inherent to expression time series, both from a computational and a biological perspective. BiGGEsTS makes available state-of-the-art biclustering algorithms for analyzing expression time series. Gene Ontology (GO) annotations are used to assess the biological relevance of the biclusters. Methods for preprocessing expression time series and post-processing results are also included. The analysis is additionally supported by a visualization module capable of displaying informative representations of the data, including heatmaps, dendrograms, expression charts and graphs of enriched GO terms. BiGGEsTS is a free open source graphical software tool for revealing local coexpression of genes in specific intervals of time, while integrating meaningful information on gene annotations. It is freely available at: http://kdbio.inesc-id.pt/software/biggests. We present a case study on the discovery of transcriptional regulatory modules in the response of Saccharomyces cerevisiae to heat stress.

  14. Impôts en France : réunion publique le mercredi 19 mars 2014

    CERN Document Server

    CERN. Geneva

    2014-01-01

    Impôts en France : réunion publique le mercredi 19 mars 2014 Une réunion publique aura lieu le mercredi 19 mars de 13h à 15h dans l’amphithéâtre principal (500/1-001). Au cours de cette réunion, MM. Jean-Louis Brandolin et Gérard Polizzi, respectivement responsable et responsable-adjoint du Service des impôts des particuliers et des entreprises de Bellegarde, Centre des finances publiques, apporteront leur expertise au sujet de l’imposition des membres du personnel du CERN domiciliés en France. Seront à l’ordre du jour les questions de principe que se posent apparemment de nombreux membres du personnel : par exemple, la définition du domicile fiscal, le contenu de la déclaration de revenus (mention des revenus CERN et déclaration des autres revenus de sources française ou étrangère), la déclaration des comptes bancaires à l’étranger, l’assujettissement (dans certaines conditions) à la CSG-CRDS. Cette réunion publique portera UNIQUEMENT sur des questions de principe ...

  15. Heparin promotes suspension adaptation process of CHO-TS28 cells by eliminating cell aggregation.

    Science.gov (United States)

    Li, Ling; Qin, Jun; Feng, Qiang; Tang, Hao; Liu, Rong; Xu, Liqing; Chen, Zhinan

    2011-01-01

    While heparin has been shown to eliminate cell aggregation in suspension adaptations of insect and HEK293 cells for virus-based cell cultures, the role of heparin in long period serum-free suspension adaptation of the anchorage-dependent Chinese hamster ovary (CHO) cell lines remains inconclusive. In this paper, we explore the potential application of heparin in suspension adaptation of CHO cell line which produces an anti-human chimeric antibody cHAb18. Heparin showed a concentration-dependent inhibition of CHO-TS28 cell-to-cell adhesion, with a significant inhibitory effect occurring when the concentration exceeded 250 μg/ml (P cell aggregation elimination role at all concentrations (P cell growth and antibody secretion, with the highest cell density ((99.83 ± 12.21) × 10(4) cells/ml, P = 0.034) and maximum antibody yield ((9.46 ± 0.94) mg/l, P cell aggregates were effectively dispersed by 250 μg/ml heparin and a single-cell suspension culture process was promoted. In suspension adapted CHO-TS28 cells, cell growth rates and specific antibody productivity were maintained; while antigen-binding activity improved slightly. Together, our results show that heparin may promote suspension adaptation of anchorage-depended CHO cells by resisting cell aggregation without reducing cell growth, antibody secretion, and antigen-binding activity.

  16. [Recurrence of esophageal cancer treated by combination TS-1/CDDP therapy].

    Science.gov (United States)

    Hiraki, Masatsugu; Yunotani, Seiji; Noguchi, Ryo; Shinozaki, Yukari; Tani, Hiroki; Sakai, Masashi; Ishimitsu, Toshiyuki; Tabuchi, Masanobu

    2005-02-01

    A 68-year-old man underwent subtotal esophagectomy with two fields lymphadenectomy and postoperative chemotherapy so called low dose FP therapy for advanced esophageal cancer (Stage IIIa, pT 3, pN 1, M 0) in October 1999. As he was diagnosed with a recurrence of esophageal cancer as metastatic lymph node tumors which were placed in the right anterocervical and supraclavicular region in March 2001, he underwent enucleation of metastatic lymph node tumors and postoperative chemoradiation therapy, so-called low-dose FP-R therapy. Recently, since other metastatic lymph node tumors in the neck appeared again in August 2001, he underwent radical neck lymph node dissection and postoperative chemoradiation treatment, so-called FAP-R therapy. In October 2003, a chest CT showed multiple lung tumors. He was diagnosed with multiple metastatic lung tumors originating from esophageal cancer. Then, two courses of a combined chemotherapy consisting of TS-1 and CDDP were administered at an interval of one month. We judged the effect of this chemotherapy to be a partial response (PR), because the largest metastatic lung tumor 18 mm in diameter showed a reduction rate of 81.9%, and other tumors had almost disappeared in the chest CT after the combined therapy. No severe adverse effects of more than grade 3 were observed during this combined therapy. This combined chemotherapy consisting of TS-1 and CDDP may prove effective for treating recurrent cases of esophageal cancer.

  17. Hybrid Vehicle Turbine Engine Technology Support (HVTE-TS) ceramic design manual

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    This ceramic component design manual was an element of the Advanced Turbine Technology Applications Project (ATTAP). The ATTAP was intended to advance the technological readiness of the ceramic automotive gas turbine engine as a primary power plant. Of the several technologies requiring development before such an engine could become a commercial reality, structural ceramic components represented the greatest technical challenge, and was the prime focus of the program. HVTE-TS, which was created to support the Hybrid Electric Vehicle (HEV) program, continued the efforts begun in ATTAP to develop ceramic components for an automotive gas turbine engine. In HVTE-TS, the program focus was extended to make this technology applicable to the automotive gas turbine engines that form the basis of hybrid automotive propulsion systems consisting of combined batteries, electric drives, and on-board power generators as well as a primary power source. The purpose of the ceramic design manual is to document the process by which ceramic components are designed, analyzed, fabricated, assembled, and tested in a gas turbine engine. Interaction with ceramic component vendors is also emphasized. The main elements of the ceramic design manual are: an overview of design methodology; design process for the AGT-5 ceramic gasifier turbine rotor; and references. Some reference also is made to the design of turbine static structure components to show methods of attaching static hot section ceramic components to supporting metallic structures.

  18. Oxidation of Catechol using Titanium Silicate (TS-1 Catalyst: Modeling and Optimization

    Directory of Open Access Journals (Sweden)

    Sonali Sengupta

    2013-12-01

    Full Text Available The oxidation of catechol was studied in an eco-friendly process with commercial titanium silicate-1 (TS-1 catalyst and hydrogen peroxide as oxidant in absence of all mass transfer effects. The process was opti-mized by Box-Behnken design in terms of three independent process variables such as reaction tempera-ture, moles of hydrogen peroxide per mole of catechol and catalyst amount whose optimum values of the process variables were found to be 60 °C, 13.2 and 1.24 g respectively for maximum conversion of 75.8 %. The effects of different process parameters such as mole ratio of hydrogen peroxide to catechol, catalyst par-ticle size, catalyst amount, temperature and reaction time were studied. A pseudo first order kinetic model was fitted with the experimental rate data. The apparent activation energy for the reaction was found to be 11.37 kJ/mole.  © 2013 BCREC UNDIP. All rights reservedReceived: 22nd April 2013; Revised: 25th October 2013; Accepted: 1st November 2013[How to Cite: Sengupta, S., Ghosal, D., Basu, J.K. (2013. Oxidation of Catechol using Titanium Silicate (TS-1 Catalyst: Modeling and Optimization. Bulletin of Chemical Reaction Engineering & Catalysis, 8 (2: 167-177. (doi:10.9767/bcrec.8.2.4759.167-177][Permalink/DOI: http://dx.doi.org/10.9767/bcrec.8.2.4759.167-177

  19. [A case of metastatic gastric cancer treated with CDDP plus TS-1 and surgical resection].

    Science.gov (United States)

    Shimizu, Junzo; Masutani, Seizo; Imamura, Hiroshi; Furukawa, Hiroshi; Kato, Hitoshi; Ezumi, Kouji; Masuda, Norikazu; Ishida, Hideyuki; Tatsuta, Masayuki; Kawasaki, Takatoshi

    2002-11-01

    Advanced gastric cancer (AGC) with liver metastasis has a poor prognosis. We encountered a case of AGC with multiple liver metastasis treated with chemotherapy and surgery. A 54-year-old male. He was admitted to our hospital with epigastric pain. Gastrointestinal fiberscope examination revealed gastric cancer. A CT scan showed regional and para-aortic lymph node (LN) swelling and multiple hepatic metastasis in the left hepatic lobe. The serum CEA level was 100.6 ng/dl. He was administered 4 courses of CDDP (100 mg (day 8 i.v.)) plus TS-1 (120 mg/day day 1-21 p.o.). After the chemotherapy, CT showed a reduction of liver metastasis and disappearance of the LN swelling. The serum CEA levels were normalized. Distal gastrectomy, partial hepatectomy, and microwave coagulation therapy were performed. After operation, he was administered 4 courses of CDDP/TS-1 additionally. Surgery may be one of therapeutic option for AGC with liver metastasis that has responded to chemotherapy, as in the present case.

  20. Improving molecular docking through eHiTS' tunable scoring function

    Science.gov (United States)

    Ravitz, Orr; Zsoldos, Zsolt; Simon, Aniko

    2011-11-01

    We present three complementary approaches for score-tuning that improve docking performance in pose prediction, virtual screening and binding affinity assessment. The methodology utilizes experimental data to customize the scoring function for the system of interest considering the specific docking scenario. The tuning approach, which has been implemented as an automated utility in eHiTS, is introduced as a solution to one of the conundrums of the molecular docking paradigm, namely, the lack of a universally well performing scoring function. The accuracy of scoring functions has been shown to be generally system-dependent, and particularly lacking for binding energy and bio-activity predictions. In the proposed approach, pose and energy predictions are enhanced by adjusting the relative weights of the eHiTS energy terms to improve score-RMSD or score-affinity correlations. In a virtual screening context ligand-based similarity is used to rescale the docking score such that better enrichment factors are achieved. We discuss the algorithmic details of the methods, and demonstrate the effects of score tuning on a variety of targets, including CDK2, BACE1 and neuraminidase, as well as on the popular benchmarks—the Directory of Useful Decoys and the PDBBind database.

  1. OTE-TS--a new value-added telematics service for telemedicine applications.

    Science.gov (United States)

    Karavatselou, E I; Economou, G P; Chassomeris, C A; Danelli-Mylonas, V; Lymberopoulos, D K

    2001-09-01

    A new telemedicine service denoted as the Hellenic Telecommunication Organization Telemedicine Service (OTE-TS), which addresses an open multidisciplinary group of medical care providers (users), is presented in this paper. OTE-TS is supported by the Hellenic Telecommunication Organization (OTE) and is the result of the close collaboration of engineers, medical doctors, and market analysts. Its architecture provides the user with an integrated electronic working domain handling diverse types of conversational audiovisual information and medical records. It includes a stack of functions, protocols, and interfaces for data acquisition, processing, and display, and for the composition of dial-up multiparty cooperation schemes (synchronous or asynchronous), suitable for the coordination and management of high-level consult, report, and review activities. The service provider (i.e., the OTE) performs the central administration and maintenance of the service, as well as the management of medical cases and reports that are exchanged among the users. The service has been extensively tested in real-world conditions.

  2. RRM1, ERCC1 and TS1 Immunofluorescence Expression in Leiomyosarcoma: A Tissue Microarray Study with Clinical Outcome Correlation Analysis.

    Science.gov (United States)

    Zheng, Sam D; Bui, Katherine; Chiappori, Alberto; Bepler, Gerold; Bui, Marilyn M

    2016-07-01

    ERCC1, RRM1 and TS1 are reportedly linked to chemotherapy resistance in lung and other cancers. However, there are currently no studies reporting the relationship between these genes and clinical parameters in leiomyosarcomas. This study investigated the expression pattern of ERCC1, RRM1 and TS1 in forty-four leiomyosarcoma samples by the use of tissue microarray (TMA), immunofluorescence and AQUA methods. The results were then analyzed for expression level and correlations were made with clinical outcome to determine their potential prognostic value in leiomyosarcoma. In the forty-four samples studied, the expression level of these three proteins can be well quantified in the AQUA system and reflected by the AQUA score. RRM1 and ERCC1 expression levels did not show any relationship with overall survival. However, a correlation was found between TS1 expression in the cytoplasm and overall survival. The high expression group had a shorter overall survival time (log-rank p = 0.0498). This trend was confirmed by the Cox proportional hazards model. The poor overall survival of leiomyosarcoma is linked to TS1 cytoplasm expression which may be useful in predicting prognoses of this tumor, methods targeting expression of TS1 may lead to improved overall survival in leiomyosarcoma, though more detailed information regarding treatment information and a larger sample size is needed to confirm this phenomenon.

  3. Interstitial lung disease caused by TS-1: a case of long-term drug retention as a fatal adverse reaction.

    Science.gov (United States)

    Park, Joong-Min; Hwang, In Gyu; Suh, Suk-Won; Chi, Kyong-Choun

    2011-12-01

    TS-1 is an oral anti-cancer agent for gastric cancer with a high response rate and low toxicity. We report a case of long-term drug retention of TS-1 causing interstitial lung disease (ILD) as a fatal adverse reaction. A 65-year-old woman underwent a total gastrectomy with pathologic confirmation of gastric adenocarcinoma. She received 6 cycles of TS-1 and low-dose cisplatin for post-operative adjuvant chemotherapy followed by single-agent maintenance therapy with TS-1. After 8 months, the patient complained of a productive cough with sputum and mild dyspnea. A pulmonary evaluation revealed diffuse ILD in the lung fields, bilaterally. In spite of discontinuing chemotherapy and the administration of corticosteroids, the pulmonary symptoms did not improve, and the patient died of pulmonary failure. TS-1-induced ILD can be caused by long-term drug retention that alters the lung parenchyma irreversibly, the outcome of which can be life-threatening. Pulmonary evaluation for early detection of disease is recommended.

  4. Evaluation of the non-catalytic binding function of Ts26GST a glutathione transferase isoform of Taenia solium.

    Science.gov (United States)

    Plancarte, A; Romero, J R; Nava, G; Reyes, H; Hernández, M

    2014-03-01

    Taenia solium glutathione transferase isoform of 26.5 kDa (Ts26GST) was observed to bind non-catalytically to porphyrins, trans-trans-dienals, bile acids and fatty acids, as assessed by inhibition kinetics, fluorescence spectroscopy and competitive fluorescence assays with 8-anilino-1-naphthalene sulfonate (ANS). The quenching of Ts26GST intrinsic fluorescence allowed for the determination of the dissociation constants (KD) for all ligands. Obtained data indicate that Ts26GST binds to all ligands but with different affinity. Porphyrins and lipid peroxide products inhibited Ts26GST catalytic activity up to 100% in contrast with only 20-30% inhibition observed for bile acids and two saturated fatty acids. Non-competitive type inhibition was observed for all enzyme inhibitor ligands except for trans-trans-2,4-decadienal, which exhibited uncompetitive type inhibition. The dissociation constant value KD = 0.7 μM for the hematin ligand, determined by competitive fluorescence assays with ANS, was in good agreement with its inhibition kinetic value Ki = 0.3 μM and its intrinsic fluorescence quenching KD = 0.7 μM. The remaining ligands did not displace ANS from the enzyme suggesting the existence of different binding sites. In addition to the catalytic activity of Ts26GST the results obtained suggest that the enzyme exhibits a ligandin function with broad specificity towards nonsubstrate ligands.

  5. ISO/TS16949-The Latest International Standard for Quality management System%ISO/TS16949--汽车行业最新的国际性质量管理体系标准

    Institute of Scientific and Technical Information of China (English)

    王景祜

    2004-01-01

    目前,在汽车工业全球化的形势下,原先的QS9000、VDA6.1、EAQF94、AVSQ94、ISO9000等质量体系标准已经不能满足全球范围的顾客要求,因此,国际标准组织(ISO)就推出了管理理念更新、更成熟的ISO/TS16949.文章简要地介绍了ISO/TS16949与ISO9000、QS9000、VDA6.1之间的关系,说明了推行ISO/TS16949的效益及其发展前途.

  6. Comparison of TS and ANN Models with the Results of Emission Scenarios in Rainfall Prediction

    Directory of Open Access Journals (Sweden)

    S. Babaei Hessar

    2016-02-01

    Full Text Available Introduction: Precipitation is one of the most important and sensitive parameters of the tropical climate that influence the catchments hydrological regime. The prediction of rainfall is vital for strategic planning and water resources management. Despite its importance, statistical rainfall forecasting, especially for long-term, has been proven to be a great challenge due to the dynamic nature of climate phenomena and random fluctuations involved in the process. Various methods, such as time series and artificial neural network models, have been proposed to predict the level of rainfall. But there is not enough attention to global warming and climate change issues. The main aim of this study is to investigate the conformity of artificial neural network and time series models with climate scenarios. Materials and Methods: For this study, 50 years of daily rainfall data (1961 to 2010 of the synoptic station of Urmia, Tabriz and Khoy was investigated. Data was obtained from Meteorological Organization of Iran. In the present study, the results of two Artificial Neural Network (ANN and Time Seri (TS methods were compared with the result of the Emission Scenarios (A2 & B1. HadCM3 model in LARS-WG software was used to generate rainfall for the next 18 years (2011-2029. The results of models were compared with climate scenarios over the next 18 years in the three synoptic stations located in the basin of the Lake Urmia. At the first stage, the best model of time series method was selected. The precipitation was estimated for the next 18 years using these models. For the same period, precipitation was forecast using artificial neural networks. Finally, the results of two models were compared with data generated under two scenarios (B1 and A2 in LARS-WG. Results and Discussion: Different order of AR, MA and ARMA was examined to select the best model of TS The results show that AR(1 was suitable for Tabriz and Khoy stations .In the Urmia station MA(1 was

  7. 猪囊尾蚴半胱氨酸蛋白酶 TsCL-1结构的同源模建%Structure Homology Modeling of Cysticercus Cellulose Cysteine Protease TsCL-1

    Institute of Scientific and Technical Information of China (English)

    杨琳; 赵琴平; 杨力权

    2016-01-01

    通过同源模建方法构建猪囊尾蚴半胱氨酸蛋白酶TsCL-1的三维结构模型,并对其结构进行分析。结果表明,TsCL-1的结构模型具有半胱氨酸蛋白酶CA族典型的α/β折叠模式,结构骨架主要由两个不同的结构域组成。结构模型具有保守的半胱氨酸催化三聚体(Cys25-His163-Asn183),催化三聚体位于两个结构域的表面,结构模型中存在3对二硫键。研究结果将为进一步深入研究TsCL-1的结构和功能关系奠定结构基础。%In this article,structural model of Cysticercus cellulose cysteine protease TsCL-1 is con-structed and analyzed. The results show that the structural model of TsCL-1 has the commonα/βscaffold characteristics of the clan CA proteases of Cysteine Protease,which contains two main structural domains. The catalytic triad residues Cys,His and Asn are completely conserved (Cys25-His163-Asn183). The structural model has three disulfide bonds. The results of this article will provide a solid basis for further studying the relationship between structure and function of TsCL-1.

  8. Research on the Application of Particular Requirements in ISO/TS 16949 for Enterprises%企业应用ISO/TS16949特殊要求的研究

    Institute of Scientific and Technical Information of China (English)

    刘璇; 尹显东; 乔建军; 闫玮

    2011-01-01

    ISO/TS 16949 is a technical standard based on ISO 9001 and additional particular re- quirements of automotive industry. Most enterprises in automotive industries upgrade dieir management system to ISO/TS 16949 on the basis of ISO 9001 quality management system, however, there are tens of particular requirements in TS 16949,how to upgrade effectively is the problem. Therefore, the paper classified the particular requirements and proposed an upgrading method including the "controlling system of processes", the"compositive auditing system"and the"application system of FIVE TOOLS".%ISO/TS 16949是在ISO 9001标准的基础上,结合汽车行业的特殊要求所形成的技术规范.大多数汽车行业配套企业都是在ISO 9001质量体系的基础上升级至TS 16949体系,然而TS 16949增加的特殊要求有近百项之多,如何有效地升级是企业需要面对的问题.为此,本文对这些特殊要求进行了系统分类,提出了建立“以过程为单位的管控体系”、“多角度的审核体系”、“五大工具应用体系”3个系统的升级思路.

  9. 天钢生产TS06拉丝专用钢盘条的实践%Practice of Producing Special Steel Wire Rod forTS06 Wire-drawing

    Institute of Scientific and Technical Information of China (English)

    王永然; 李召岭; 王兰香

    2007-01-01

    介绍了天钢利用顶底复吹转炉、LF精炼炉、方坯连铸、高速线材轧机工艺生产TS06拉丝专用钢盘条的实践.通过对转炉终点控制、LF钢包精炼工艺及控冷控轧工艺等方面的探索,顺利生产出了TS06低碳拉丝专用钢盘条,完全能够满足镀锌钢丝生产的需求.

  10. Research on the Implementation of ISO/TS 16949 in the Manufacturing Company of the Automobile%对汽车制造企业推行ISO/TS16949的探讨

    Institute of Scientific and Technical Information of China (English)

    陈君宁; 胡婷

    2004-01-01

    本文简述了汽车生产和相关服务组织的质量管理体系的最新标准--ISO/TS16949对汽车制造企业的重要作用和意义,针对汽车制造企业在推行ISO/TS16949过程中的关键问题进行分析, 同时对如何实施推行这一标准提出了一些建议.

  11. Synthesis of Mesoporous TS-1 Zeolite Microspheres and Catalytic Property in Cyclohexanone Ammoximation%介孔TS-1分子筛微球合成及其催化环己酮氨肟化反应性能

    Institute of Scientific and Technical Information of China (English)

    王振东; 徐乐; 何鸣元; 吴鹏

    2013-01-01

    Mesoporous TS-1 zeolite microspheres were synthesized by hydrothermal crystallization with the assistance of triblock copolymer F127, and they were employed as the catalysts for the liquid-phase ammoximation of cyclohexanone with ammonia and hydrogen peroxide. The reaction parameters, molar ratio of H2O2 to cyclohexanone and NH3 to cyclohexanone, which governed the cyclohexanone conversion, oxime selectivity and catalyst deactivation, were investigated by simulating the operating conditions in an industrial process. Under optimized reaction conditions of temperature 75 ℃, molar ratio of H2O2 to cyclohexanone 1.1, molar ratio of NH3 to cyclohexanone 1.7, WHSV 6.3 h-1, mesoporous TS-1 microspheres exhibited cyclohexanone conversion above 98% and oxime selectivity above 99%. Moreover, the TS-1 microsphere catalyst showed a longer lifetime than conventional nanosized TS-1 particles.%采用三嵌段非离子型表面活性剂F127辅助水热晶化制得介孔TS-1分子筛微球,并详细考察了反应温度、氨酮比、双氧水与环己酮之比对 TS-1分子筛微球催化液相连续淤浆床环己酮氨肟化反应性能的影响。结果表明:在反应温度75℃,氨与环己酮物质的量之比1.1,双氧水与环己酮物质的量之比1.7,质量空速6.3 h-1的反应条件下,TS-1分子筛微球显示出与常规纳米TS-1分子筛相当的环己酮转化率和环己酮肟的选择性,分别达98%和99%,但前者具有更高的稳定性。

  12. National Difference in Intelligence: A Review of the Work of Lynn and Vanhanen%国民智商:有关智力国别差异的研究

    Institute of Scientific and Technical Information of China (English)

    Lynn R.; Vanhanen T; 周静; 谢天(译)

    2012-01-01

    国民智商是某国家或地区民众智商的平均值。RichardLynn与TatuVanhanen教授调查了近两百个国家,给出了全球的国民智商。他们发现,国民智商与国家经济、文化、政治,及国民健康等均呈正高度正相关,并以一个两阶因果模型解释该现象。%National Intelligence is the average intelligence in a country or region. Richard Lynn and Tatu Vanhanen surveyed almost 200 countries in the world, and reported the national intelligence differences in the world. They found that the national IQs correlated highly and positively with national economics, cultural, politics, and national health. They also proposed a two-stage causal model to account for these phenomena.

  13. Fuzzy dynamic output feedback H∞ control for continuous-time T-S fuzzy systems under imperfect premise matching.

    Science.gov (United States)

    Zhao, Tao; Dian, Songyi

    2017-09-01

    This paper addresses a fuzzy dynamic output feedback H∞ control design problem for continuous-time nonlinear systems via T-S fuzzy model. The stability of the fuzzy closed-loop system which is formed by a T-S fuzzy model and a fuzzy dynamic output feedback H∞ controller connected in a closed loop is investigated with Lyapunov stability theory. The proposed fuzzy controller does not share the same membership functions and number of rules with T-S fuzzy systems, which can enhance design flexibility. A line-integral fuzzy Lyapunov function is utilized to derive the stability conditions in the form of linear matrix inequalities (LMIs). The boundary information of membership functions is considered in the stability analysis to reduce the conservativeness of the imperfect premise matching design technique. Two simulation examples are provided to demonstrate the effectiveness of the proposed approach. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  14. Characterization of TS-mutants of cyanophage N-1 by their inactivation by physical and chemical agents.

    Science.gov (United States)

    Sarma, T A; Singh, R

    1995-04-01

    The effect of temperature, ultraviolet (UV) light and ethylenediaminetetraacetic acid (EDTA) on the stability of cyanophage N-1, infecting the cyanobacterium Nostoc muscorum was studied. Complete inactivation of the phage occurred at 60 degrees C in 6 mins. All the temperature-sensitive (ts) mutants exhibited faster inactivation at 50 degrees C than the wild type. UV light readily inactivated the particles of the wild giving a survival of 3.44% at a dose of 60 secs. All the ts-mutants were found to be more sensitive to UV light than the wild type. 10(-4) mol/l EDTA inactivated 40% of the wild type in 60 mins. 5 x 10(-4) mol/l EDTA inactivated the wild type nearly completely within 2 mins, while a similar inactivation of ts-mutants required only 90 secs.

  15. Heterologous Prime-Boost Vaccination Enhances TsPmy’s Protective Immunity against Trichinella spiralis Infection in a Murine Model

    Directory of Open Access Journals (Sweden)

    Lei Wang

    2017-07-01

    Full Text Available TsPmy is a paramyosin expressed by parasitic Trichinella spiralis and confers a protective immunity when its recombinant protein or DNA was used as an immunogen. To improve its immunogenicity and vaccine efficacy, we conducted a heterologous prime-boost strategy by orally delivering one dose of TsPmy DNA carried by attenuated Salmonella typhimurium (SL7207, followed by two doses of recombinant TsPmy intramuscularly. This strategy effectively induced intestinal mucosal sIgA response and an enhanced and balanced Th1/Th2 immune responses that improve protection against T. spiralis larval challenge, with 55.4% muscle larvae reduction and 41.8% adult worm reduction compared to PBS control. The muscle larvae reduction induced by heterologous prime-boost regimen was significant higher than that induced by the homologous DNA or protein prime-boost regimens, which could act as a practical prophylactic approach to prevent T. spiralis infection.

  16. A Novel Adjustment Method for Shearer Traction Speed through Integration of T-S Cloud Inference Network and Improved PSO

    Directory of Open Access Journals (Sweden)

    Lei Si

    2014-01-01

    Full Text Available In order to efficiently and accurately adjust the shearer traction speed, a novel approach based on Takagi-Sugeno (T-S cloud inference network (CIN and improved particle swarm optimization (IPSO is proposed. The T-S CIN is built through the combination of cloud model and T-S fuzzy neural network. Moreover, the IPSO algorithm employs parameter automation adjustment strategy and velocity resetting to significantly improve the performance of basic PSO algorithm in global search and fine-tuning of the solutions, and the flowchart of proposed approach is designed. Furthermore, some simulation examples are carried out and comparison results indicate that the proposed method is feasible, efficient, and is outperforming others. Finally, an industrial application example of coal mining face is demonstrated to specify the effect of proposed system.

  17. Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome.

    Directory of Open Access Journals (Sweden)

    Md Mahiuddin Ahmed

    Full Text Available Down syndrome (DS is caused by an extra copy of human chromosome 21 (Hsa21. Although it is the most common genetic cause of intellectual disability (ID, there are, as yet, no effective pharmacotherapies. The Ts65Dn mouse model of DS is trisomic for orthologs of ∼55% of Hsa21 classical protein coding genes. These mice display many features relevant to those seen in DS, including deficits in learning and memory (L/M tasks requiring a functional hippocampus. Recently, the N-methyl-D-aspartate (NMDA receptor antagonist, memantine, was shown to rescue performance of the Ts65Dn in several L/M tasks. These studies, however, have not been accompanied by molecular analyses. In previous work, we described changes in protein expression induced in hippocampus and cortex in control mice after exposure to context fear conditioning (CFC, with and without memantine treatment. Here, we extend this analysis to Ts65Dn mice, measuring levels of 85 proteins/protein modifications, including components of MAP kinase and MTOR pathways, and subunits of NMDA receptors, in cortex and hippocampus of Ts65Dn mice after failed learning in CFC and after learning was rescued by memantine. We show that, compared with wild type littermate controls, (i of the dynamic responses seen in control mice in normal learning, >40% also occur in Ts65Dn in failed learning or are compensated by baseline abnormalities, and thus are considered necessary but not sufficient for successful learning, and (ii treatment with memantine does not in general normalize the initial protein levels but instead induces direct and indirect responses in approximately half the proteins measured and results in normalization of the endpoint protein levels. Together, these datasets provide a first view of the complexities associated with pharmacological rescue of learning in the Ts65Dn. Extending such studies to additional drugs and mouse models of DS will aid in identifying pharmacotherapies for effective

  18. TsTx toxin isolated from Tityus serrulatus scorpion venom induces spontaneous recurrent seizures and mossy fiber sprouting.

    Science.gov (United States)

    Sandoval, Maria Regina Lopes; Lebrun, Ivo

    2003-07-01

    To characterize the long-term behavioral, electroencephalographic (EEG) and histopathologic features after a single TsTx microinjection into the hippocampus of rats. TsTx, 2 microg, or 1 microl of 0.1 M phosphate buffer was injected into the right dorsal hippocampus of the rat. EEG records and behavioral observations were made over a period of 10 h after injection. For a period of 4 months, the animals were observed for the occurrence of convulsive seizures. At the end of the experiment, the brains were processed by the neo-Timm and Nissl methods. After intrahippocampal TsTx injection, three distinct phases were observed: (a) an immediate period that lasted 1 day, during which the motor and electrographic seizures characteristic of status epilepticus (SE) were seen; (b) a silent period (31-49 days), characterized by normal EEG and behavior; and (c) a period of spontaneous recurrent seizures (SRSs). The seizure frequency was one to two per week. Four months after TsTx injection, hippocampal neuronal loss and mossy fiber sprouting in the supragranular layer of the dentate gyrus were observed. The SRSs observed in this study may be associated with the TsTx-induced SE and brain damage. All animals injected with the toxin showed massive pyramidal neuronal loss in the dorsal hippocampus as well as intense gliosis and atrophy. Mossy fiber sprouting in the supragranular layer of the dentate gyrus was observed in those animals that had SRSs. The effects observed may be due, at least in part, to TsTx-enhanced release of glutamate in hippocampal pathways.

  19. A novel secretory poly-cysteine and histidine-tailed metalloprotein (Ts-PCHTP from Trichinella spiralis (Nematoda.

    Directory of Open Access Journals (Sweden)

    Georgi Radoslavov

    Full Text Available BACKGROUND: Trichinella spiralis is an unusual parasitic intracellular nematode causing dedifferentiation of the host myofiber. Trichinella proteomic analyses have identified proteins that act at the interface between the parasite and the host and are probably important for the infection and pathogenesis. Many parasitic proteins, including a number of metalloproteins are unique for the nematodes and trichinellids and therefore present good targets for future therapeutic developments. Furthermore, detailed information on such proteins and their function in the nematode organism would provide better understanding of the parasite-host interactions. METHODOLOGY/PRINCIPAL FINDINGS: In this study we report the identification, biochemical characterization and localization of a novel poly-cysteine and histidine-tailed metalloprotein (Ts-PCHTP. The native Ts-PCHTP was purified from T. spiralis muscle larvae that were isolated from infected rats as a model system. The sequence analysis showed no homology with other proteins. Two unique poly-cysteine domains were found in the amino acid sequence of Ts-PCHTP. This protein is also the first reported natural histidine tailed protein. It was suggested that Ts-PCHTP has metal binding properties. Total Reflection X-ray Fluorescence (TXRF assay revealed that it binds significant concentrations of iron, nickel and zinc at protein:metal ratio of about 1:2. Immunohistochemical analysis showed that the Ts-PCHTP is localized in the cuticle and in all tissues of the larvae, but that it is not excreted outside the parasite. CONCLUSIONS/SIGNIFICANCE: Our data suggest that Ts-PCHTP is the first described member of a novel nematode poly-cysteine protein family and its function could be metal storage and/or transport. Since this protein family is unique for parasites from Superfamily Trichinelloidea its potential applications in diagnostics and treatment could be exploited in future.

  20. Long-term running alleviates some behavioral and molecular abnormalities in Down syndrome mouse model Ts65Dn.

    Science.gov (United States)

    Kida, Elizabeth; Rabe, Ausma; Walus, Marius; Albertini, Giorgio; Golabek, Adam A

    2013-02-01

    Running may affect the mood, behavior and neurochemistry of running animals. In the present study, we investigated whether voluntary daily running, sustained over several months, might improve cognition and motor function and modify the brain levels of selected proteins (SOD1, DYRK1A, MAP2, APP and synaptophysin) in Ts65Dn mice, a mouse model for Down syndrome (DS). Ts65Dn and age-matched wild-type mice, all females, had free access to a running wheel either from the time of weaning (post-weaning cohort) or from around 7 months of age (adult cohort). Sedentary female mice were housed in similar cages, without running wheels. Behavioral testing and evaluation of motor performance showed that running improved cognitive function and motor skills in Ts65Dn mice. However, while a dramatic improvement in the locomotor functions and learning of motor skills was observed in Ts65Dn mice from both post-weaning and adult cohorts, improved object memory was seen only in Ts65Dn mice that had free access to the wheel from weaning. The total levels of APP and MAP2ab were reduced and the levels of SOD1 were increased in the runners from the post-weaning cohort, while only the levels of MAP2ab and α-cleaved C-terminal fragments of APP were reduced in the adult group in comparison with sedentary trisomic mice. Hence, our study demonstrates that Ts65Dn females benefit from sustained voluntary physical exercise, more prominently if running starts early in life, providing further support to the idea that a properly designed physical exercise program could be a valuable adjuvant to future pharmacotherapy for DS.

  1. Epoxidation of allyl alcohol to glycidol over the microporous TS-1 catalyst.

    Science.gov (United States)

    Wróblewska, Agnieszka; Fajdek, Anna

    2010-07-15

    The results of the epoxidation of allyl alcohol with 30% hydrogen peroxide over the TS-1 catalyst have been presented. The studies were carried out under the atmospheric pressure and at the presence of methanol as a solvent. The influence of the following technological parameters on the course of epoxidation was examined: the temperature of 20-60 degrees C, the molar ratio of AA/H(2)O(2) 1:1-5:1, the methanol concentration of 5-90 wt%, the catalyst content of 0.1-5.0 wt% and the reaction time 5-300 min. The main functions describing the process were the selectivity to glycidol in relation to allyl alcohol consumed, the conversion of substrates, and the selectivity of transformation to organic compounds in relation to hydrogen peroxide consumed. The parameters at which the functions describing the process reached the highest values were determined.

  2. Tuning of a TS Fuzzy Output Regulator Using the Steepest Descent Approach and ANFIS

    Directory of Open Access Journals (Sweden)

    Ricardo Tapia-Herrera

    2013-01-01

    Full Text Available The exact output regulation problem for Takagi-Sugeno (TS fuzzy models, designed from linear local subsystems, may have a solution if input matrices are the same for every local linear subsystem. Unfortunately, such a condition is difficult to accomplish in general. Therefore, in this work, an adaptive network-based fuzzy inference system (ANFIS is integrated into the fuzzy controller in order to obtain the optimal fuzzy membership functions yielding adequate combination of the local regulators such that the output regulation error in steady-state is reduced, avoiding in this way the aforementioned condition. In comparison with the steepest descent method employed for tuning fuzzy controllers, ANFIS approximates the mappings between local regulators with membership functions which are not necessary known functions as Gaussian bell (gbell, sigmoidal, and triangular membership functions. Due to the structure of the fuzzy controller, Levenberg-Marquardt method is employed during the training of ANFIS.

  3. CAPACITATED LOT SIZING AND SCHEDULING PROBLEMS USING HYBRID GA/TS APPROACHES

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The capacitated lot sizing and scheduling problem that involves in determining the production amounts and release dates for several items over a given planning horizon are given to meet dynamic order demand without incurring backloggings. The problem considering overtime capacity is studied. The mathematical model is presented, and a genetic algorithm (GA) approach is developed to solve the problem. The initial solutions are generated after using heuristic method. Capacity balancing procedure is employed to stipulate the feasibility of the solutions. In addition, a technique based on Tabu search (TS) is inserted into the genetic algorithm to deal with the scheduled overtime and help the convergence of algorithm. Computational simulation is conducted to test the efficiency of the proposed hybrid approach, which turns out to improve both the solution quality and execution speed.

  4. Adaptive synchronization of T-S fuzzy chaotic systems with unknown parameters

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae-Hun [Department of Electrical and Electronic Engineering, Yonsei University, 134 Shinchon-dong, Sudaemoon-gu, Seoul 120-749 (Korea, Republic of)]. E-mail: jhkim@yeics.yonsei.ac.kr; Park, Chang-Woo [Precision Machinery Research Center, Korea Electronics Technology Institute, 203-103 B/D 192, Yakdae-dong, Wonmi-gu, Puchon-si, Kyunggi-do 420-140 (Korea, Republic of); Kim, Euntai [Department of Electrical and Electronic Engineering, Yonsei University, 134 Shinchon-dong, Sudaemoon-gu, Seoul 120-749 (Korea, Republic of); Park, Mignon [Department of Electrical and Electronic Engineering, Yonsei University, 134 Shinchon-dong, Sudaemoon-gu, Seoul 120-749 (Korea, Republic of)

    2005-06-01

    This paper presents a fuzzy model-based adaptive approach for synchronization of chaotic systems which consist of the drive and response systems. Takagi-Sugeno (T-S) fuzzy model is employed to represent the chaotic drive and response systems. Since the parameters of the drive system are assumed unknown, we design the response system that estimates the parameters of the drive system by adaptive strategy. The adaptive law is derived to estimate the unknown parameters and its stability is guaranteed by Lyapunov stability theory. In addition, the controller in the response system contains two parts: one part that can stabilize the synchronization error dynamics and the other part that estimates the unknown parameters. Numerical examples, including Duffing oscillator and Lorenz attractor, are given to demonstrate the validity of the proposed adaptive synchronization approach.

  5. ISO/TS 16949新版内审员培训

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    ISO/TS16949是以ISO9001为基础,由IATF(International Automotive TaskForce国际汽车工业协会)下的各国汽车产业联合制定的质量体系要求(如Qs9000德国VDA,法国EAQF,及意大利AVSQ),并被各国汽车制造者所认可采用。适宜所有和IATF相关的汽车制造业。2002年3月AIAG(美国汽车工业行动集团)向全世界QS9000的应用公司发出通知,

  6. Quench tests of a 20-cm-long RABiTS YBCO tape

    Science.gov (United States)

    Lue, J. W.; Gouge, M. J.; Duckworth, R. C.; Lee, D. F.; Kroeger, D. M.; Pfotenhauer, J. M.

    2002-05-01

    A 20-cm-long YBCO tape fabricated by the Rolling Assisted Bi-axially Textured Substrate (RABiTS) technique was used to study the quench behavior of a second-generation high-temperature superconductor (HTS). Quench tests of the sample were performed in a conduction cooling condition with a cryocooler. The sample was subjected to a short overcurrent pulse to create normal zones, followed by a longer operating current up to the critical currents of the weaker zones of the tape. Distinctive normal zone propagation was observed for the first time on a YBCO tape. Propagation velocities of 1.4 to 8.3 mm/s were measured, which increase linearly with the current. Stability margins and a minimum propagation current were also observed. One-dimensional thermal modeling showed good agreement with the test results. [This paper is also published in Advances in Cryogenic Engineering Vol. 47A, AIP Conference Proceedings Vol. 613, pp. 457-464.

  7. Managing Pessimistic, Gloomy, and Cynical Employees: Twenty-Five Do's and Don'ts.

    Science.gov (United States)

    Hills, Laura

    2015-01-01

    Every medical practice manager has to deal with a certain amount of employee pessimism at times. But one overly pessimistic employee can spread his or her negativity to the entire medical practice team if the manager doesn't intervene. This article suggests practical strategies managers can use to deal effectively with a pessimistic, defeatist, gloomy, or cynical employee. It describes two kinds of pessimism medical practice managers may encounter and offers 25 specific management do's and don'ts for managing a pessimist. This article also offers managers guidance for firing a pessimistic employee, including sample language they can use. It provides 10 self-care strategies for practice managers so they can keep themselves from succumbing to an employee's negativity. It also suggests eight ways that pessimism can hurt the medical practice team and describes five kinds of negative thinking managers may encounter. Finally, this article explores defensive pessimism theory and the surprising benefits for managers of some pessimistic thinking.

  8. Ethnicity, development and gender: Tsáchila indigenous women in Ecuador.

    Science.gov (United States)

    Radcliffe, Sarah; Pequeño, Andrea

    2010-01-01

    In recent decades, indigenous populations have become the subjects and agents of development in national and international multicultural policy that acknowledges poverty among indigenous peoples and their historic marginalization from power over development. Although the impact of these legal and programmatic efforts is growing, one persistent axis of disadvantage, male–female difference, is rarely taken into account in ethno-development policy and practice. This article argues that assumptions that inform policy related to indigenous women fail to engage with indigenous women's development concerns. The institutional separation between gender and development policy (GAD) and multiculturalism means that provisions for gender in multicultural policies are inadequate, and ethnic rights in GAD policies are invisible. Drawing on post-colonial feminism, the paper examines ethnicity and gender as interlocking systems that structure indigenous women's development experiences. These arguments are illustrated in relation to the case of the Tsáchila ethno-cultural group in the South American country of Ecuador.

  9. Fusion of a Sendai mutant deficient in HN protein (ts271) with cardiolipin liposomes

    Energy Technology Data Exchange (ETDEWEB)

    Gibson, S.; Bundo-Morita, K.; Portner, A.; Lenard, J.

    1988-03-01

    Sendai mutant ts271 contains less than 5% of the amount of HN glycoprotein found in wild-type Sendai. Fusion of this mutant with cardiolipin liposomes revealed no differences from the wild-type virus with regard to specific activity, pH dependence, or radiation inactivation. Target sizes of both mutant and wild-type viral proteins were determined by the radiation-induced disappearance of each band from an SDS-polyacrylamide gel and no differences were found. Of the viral proteins, only F had a target size corresponding to the monomer molecular weight, ca. 60 kDa, identical to the minimum unit previously determined by functional assay for Sendai virus-erythrocyte membrane fusion. This provides additional evidence that F alone is the active protein mediating Sendai-erythrocyte fusion. It is concluded that the HN protein is unlikely to mediate any fusion reactions of the intact virions, either with biological membranes or with cardiolipin liposomes.

  10. E2F1/TS Immunophenotype and Survival of Patients with Colorectal Cancer Treated with 5FU-Based Adjuvant Therapy.

    Science.gov (United States)

    Sulzyc-Bielicka, Violetta; Domagala, Pawel; Bielicki, Dariusz; Safranow, Krzysztof; Rogowski, Wojciech; Domagala, Wenancjusz

    2016-07-01

    The predictive value of thymidylate synthase (TS) expression alone for 5FU-based treatment of colorectal cancer (CRC) has not been clinically confirmed. Little is known on the association of expression of E2F1, which controls the transcription of genes encoding proteins engaged in DNA synthesis including TS, and survival of patients with CRC. The purpose of this study is to assess the correlation between expression of both E2F1 and TS in CRCs and survival of patients administered adjuvant 5FU-based chemotherapy, in order to find a better predictor of treatment outcome than expression of TS or E2F1 alone. Nuclear TS and E2F1 were detected by immunohistochemistry in tissue microarrays from 190 CRCs (Astler-Coller stage B2 or C). Multivariate analysis identified significant association of the combined E2F1+TS+ immunophenotype with worse OS (HR = 3,78, P = 0,009) and DFS (HR = 2,30, P = 0,03) of patients with colon cancer. There were significant differences between E2F1+TS+ and E2F1-TS- Kaplan-Meier survival curves in relation to DFS (P = 0.008) and OS (P = 0.01). About 37 and 31 % difference in 3-year DFS and OS respectively were seen between patients with E2F1+TS+ vs. E2F1-TS- colon cancer immunophenotype. The E2F1+TS+ immunophenotype may be a marker of poor prognosis (the worst DFS and OS) of patients with colon cancer treated with 5FU-based adjuvant therapy. A subgroup of patients with this immunophenotype may require different and perhaps more aggressive treatment than 5FU-based chemotherapy. Thus, the combined E2F1/TS immunophenotype could be a potential indicator of colon cancer sensitivity to 5FU.

  11. A Modernist Approach to T.S Eliot’s The Love Song of J. Alfred Prufrock

    OpenAIRE

    Samet Güven

    2015-01-01

    A Modernist Approach to T.S Eliot’s “The Love Song of J. Alfred Prufrock" Abstract  T.S. Eliot’s The Love Song of J. Alfred Prufrock carries the characteristics of modernist poetry such as objective correlative, fragmentation, free verse and irregular rhyming. It suggests a direct break with English romantic poets such as Coleridge and Wordsworth (Levis 75). Sara Thorne states that unlike the Romantic poets, Eliot attempts to convey the essence of life; and the content represents actu...

  12. Robust State Feedback H∞Control for Dynamic Biped Robot Based on T-S Fuzzy Model

    Institute of Scientific and Technical Information of China (English)

    HUAI Chuangfeng; FANG Yuefa

    2006-01-01

    T-S fuzzy model was applied to describe nonlinear system and global fuzzy model was expressed by the form of uncertain system. Based on robust state feedback H∞control strategy, designed a global asymptotic steady fuzzy model. This control system can use the experimental input-output data pairs for the biped robot learning and walking with dynamic balance. It is proved by simulation result that robust state feedback H∞ control method based on T-S fuzzy model can effectively restrain the effect of model uncertainties and external disturbance acting on biped robot. From these works, we showed the satisfactory performance of joint tracking without any chattering.

  13. Event-triggered H∞ control for T-S fuzzy nonlinear systems and its application to truck-trailer system.

    Science.gov (United States)

    Cheng, Jun; Park, Ju H; Wang, Hailing

    2016-11-01

    This paper addresses the problem of event-triggered H∞ control for a class of T-S fuzzy nonlinear systems. An improved event-triggered scheme (ETS) characterized by discrete sampling is proposed, where the time-derivative of the membership function is not required. To get conservative conditions, the deviation bound of asynchronous normalized membership functions is considered. By utilizing the non-quadratic fuzzy line-integral Lyapunov functions and a free-matrix-based integral inequality, novel criteria for stabilization analysis of T-S fuzzy nonlinear systems are established. Finally, a truck-trailer system is provided to show the effectiveness of the proposed theories.

  14. Further Result on Passivity for Discrete-Time Stochastic T-S Fuzzy Systems with Time-Varying Delays

    Directory of Open Access Journals (Sweden)

    Ting Lei

    2014-01-01

    Full Text Available The passivity for discrete-time stochastic T-S fuzzy systems with time-varying delays is investigated. By constructing appropriate Lyapunov-Krasovskii functionals and employing stochastic analysis method and matrix inequality technique, a delay-dependent criterion to ensure the passivity for the considered T-S fuzzy systems is established in terms of linear matrix inequalities (LMIs that can be easily checked by using the standard numerical software. An example is given to show the effectiveness of the obtained result.

  15. Interaction between endoplasmic reticulum stress and caspase 8 activation in retrovirus MoMuLV-ts1-infected astrocytes.

    Science.gov (United States)

    Liu, Na; Scofield, Virginia L; Qiang, Wenan; Yan, Mingshan; Kuang, Xianghong; Wong, Paul K Y

    2006-05-10

    The murine retrovirus, MoMuLV-ts1, induces progressive paralysis and immune deficiency in FVB/N mice. We have reported previously that ts1 infection causes apoptosis in astrocytes via endoplasmic reticulum (ER) and mitochondrial stress (Liu, N., Kuang, X., Kim, H.T., Stoica, G., Qiang, W., Scofield, V.L., Wong, P.K.Y. Wong. 2004. Possible involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in MoMuLV-ts1-induced apoptosis in astrocytes. J. NeuroVirol. 10, 189-198). In the present study, we show that caspase 8 activation in these cells is mediated through ER stress-associated elevation of death receptor DR5 and the C/EBP homologous protein (GADD153/CHOP), an ER stress-initiated transcription factor, rather than through TNFalpha and TNF-R1 interactions on the cell surface. Treatment with Z-IETD-FMK, a specific inhibitor of caspase 8 enzymatic activity, reduced ER stress by two mechanisms: by inhibiting caspase 8 activation, and by preventing cleavage of the ER-associated membrane protein BAP31 into BAP20, which exacerbates the ER stress response. These findings suggest that caspase 8- and ER stress-associated apoptotic pathways are linked in ts1-infected astrocytes.

  16. Chronic up-regulation of the SHH pathway normalizes some developmental effects of trisomy in Ts65Dn mice.

    Science.gov (United States)

    Dutka, Tara; Hallberg, Dorothy; Reeves, Roger H

    2015-02-01

    Down Syndrome (DS) is a highly complex developmental genetic disorder caused by trisomy for human chromosome 21 (Hsa21). All individuals with DS exhibit some degree of brain structural changes and cognitive impairment; mouse models such as Ts65Dn have been instrumental in understanding the underlying mechanisms. Several phenotypes of DS might arise from a reduced response of trisomic cells to the Sonic Hedgehog (SHH) growth factor. If all trisomic cells show a similar reduced response to SHH, then up-regulation of the pathway in trisomic cells might ameliorate multiple DS phenotypes. We crossed Ptch1tm1Mps/+ mice, in which the canonical SHH pathway is expected to be up-regulated in every SHH-responsive cell due to the loss of function of one allele of the pathway suppressor, Ptch1, to the Ts65Dn DS model and assessed the progeny for possible rescue of multiple DS-related phenotypes. Down-regulation of Ptch produced several previously unreported effects on development by itself, complicating interpretation of some phenotypes, and a number of structural or behavioral effects of trisomy were not compensated by SHH signaling. However, a deficit in a nest-building task was partially restored in Ts;Ptch+/- mice, as were the structural anomalies of the cerebellum seen in Ts65Dn mice. These results extend the body of evidence indicating that reduced response to SHH in trisomic cells and tissues contributes to various aspects of the trisomic phenotype.

  17. The impact of ISO/TS 16949 on automotive industries and created organizational capabilities from its implementation

    Directory of Open Access Journals (Sweden)

    Bakhtiar Ostadi

    2010-12-01

    Full Text Available ISO/TS 16949 is an ISO Technical Specification. ISO/TS 16949 achieves the objectives which are continually to improve the production of automobile parts and related services, and to strengthen the international competition for the automotive industry and its suppliers. By applying this quality system standard, automotive manufacturers could offer superior products and good services to customers. The more the companies know about the benefits if quality management systems such as ISO/TS 16949, better they can seek interest and determine indices of these systems. So, this standard has been implemented in companies considering a number of benefits. In this paper, we carry out an empirical study in order to verify the importance these benefits and ranking them based on the value of importance. Finally, the study tends to provide a reference guide considering benefits assessment and created organizational capabilities from this standard for the automotive industry in pursuing ISO/TS 16949 and procuring maximum benefit from the results.

  18. Evaluation of a thermostable Newcastle disease virus strain TS09-C as an in-ovo vaccine for chickens

    Science.gov (United States)

    Yu, Qingzhong; Wang, Hongling; Luo, Qingping; Zhang, Tengfei; Zhang, Rongrong; Zhang, Wanpo; Shao, Huabin

    2017-01-01

    In-ovo vaccination is an attractive immunization approach for poultry industry. However, most of the Newcastle disease virus (NDV) vaccine strains used after hatch are unsafe, as in-ovo vaccines, due to their high pathogenicity for chicken embryos. In this study, we evaluated the safety and immunogenicity of a thermostable NDV strain TS09-C, derived from V4 strain, as in-ovo vaccine. Chickens in-ovo vaccinated with the parental V4 strain displayed greatly reduced hatchability and severe histopathological lesions in both trachea and intestine tissues, while the hatchability was not affected by in-ovo vaccination withTS09-C strain. The safe dose that infected all chicken embryos without obviously histopathological lesions was 103.0 EID50 per bird. In-ovo vaccination of chickens with TS09-C virus conferred complete protection against virulent NDV challenge. Results suggest that the thermostable NDV strain TS09-C is a safe and immunogenic in-ovo vaccine candidate that can be delivered quickly and uniformly, and induce earlier immune response. PMID:28234989

  19. Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins

    Science.gov (United States)

    Cremonez, Caroline M.; Maiti, Mohitosh; Peigneur, Steve; Cassoli, Juliana Silva; Dutra, Alexandre A. A.; Waelkens, Etienne; Lescrinier, Eveline; Herdewijn, Piet; de Lima, Maria Elena; Pimenta, Adriano M. C.; Arantes, Eliane C.; Tytgat, Jan

    2016-01-01

    To date, several families of peptide toxins specifically interacting with ion channels in scorpion venom have been described. One of these families comprise peptide toxins (called KTxs), known to modulate potassium channels. Thus far, 202 KTxs have been reported, belonging to several subfamilies of KTxs (called α, β, γ, κ, δ, and λ-KTxs). Here we report on a previously described orphan toxin from Tityus serrulatus venom, named Ts11. We carried out an in-depth structure-function analysis combining 3D structure elucidation of Ts11 and electrophysiological characterization of the toxin. The Ts11 structure is highlighted by an Inhibitor Cystine Knot (ICK) type scaffold, completely devoid of the classical secondary structure elements (α-helix and/or β-strand). This has, to the best of our knowledge, never been described before for scorpion toxins and therefore represents a novel, 6th type of structural fold for these scorpion peptides. On the basis of their preferred interaction with voltage-gated K channels, as compared to all the other targets tested, it can be postulated that Ts11 is the first member of a new subfamily, designated as ε-KTx. PMID:27706049

  20. A highly Conserved Aspartic Acid Residue of the Chitosanase from Bacillus Sp. TS Is Involved in the Substrate Binding.

    Science.gov (United States)

    Zhou, Zhanping; Zhao, Shuangzhi; Liu, Yang; Chang, Zhengying; Ma, Yanhe; Li, Jian; Song, Jiangning

    2016-11-01

    The chitosanase from Bacillus sp. TS (CsnTS) is an enzyme belonging to the glycoside hydrolase family 8. The sequence of CsnTS shares 98 % identity with the chitosanase from Bacillus sp. K17. Crystallography analysis and site-direct mutagenesis of the chitosanase from Bacillus sp. K17 identified the important residues involved in the catalytic interaction and substrate binding. However, despite progress in understanding the catalytic mechanism of the chitosanase from the family GH8, the functional roles of some residues that are highly conserved throughout this family have not been fully elucidated. This study focused on one of these residues, i.e., the aspartic acid residue at position 318. We found that apart from asparagine, mutation of Asp318 resulted in significant loss of enzyme activity. In-depth investigations showed that mutation of this residue not only impaired enzymatic activity but also affected substrate binding. Taken together, our results showed that Asp318 plays an important role in CsnTS activity.

  1. Effects of the Water in Mixed Solvent on the Epoxidation Reaction of Propylene with TS-1 Catalyst

    Institute of Scientific and Technical Information of China (English)

    苏泉声; 王彪; 张玉梅; 王华平

    2001-01-01

    The epoxidation reaction of propylene and hydrogen peroxide with zeolite catalyst containing titaniumsilicalite (TS-1)has been studied, and the reaction in the mixed solvent of water/methanol has been discussed. It is shown that the selective of epoxidation propylene decreases while the selective of propylene glycol increases, when the water content increases in the mixed solvent of methanol/water.

  2. Changes in carotid body and nTS neuronal excitability following neonatal sustained and chronic intermittent hypoxia exposure.

    Science.gov (United States)

    Mayer, C A; Wilson, C G; MacFarlane, P M

    2015-01-01

    We investigated whether pre-treatment with neonatal sustained hypoxia (SH) prior to chronic intermittent hypoxia (SH+CIH) would modify in vitro carotid body (CB) chemoreceptor activity and the excitability of neurons in the caudal nucleus of the solitary tract (nTS). Sustained hypoxia followed by CIH exposure simulates an oxygen paradigm experienced by extremely premature infants who developed persistent apnea. Rat pups were treated with 5 days of SH (11% O2) from postnatal age 1 (P1) followed by 10 days of subsequent chronic intermittent hypoxia (CIH, 5% O2/5 min, 8 h/day, between P6 and P15) as described previously (Mayer et al., Respir. Physiol. Neurobiol. 187(2): 167-75, 2013). At the end of SH+CIH exposure (P16), basal firing frequency was enhanced, and the hypoxic sensory response of single unit CB chemoafferents was attenuated. Further, basal firing frequency and the amplitude of evoked excitatory post-synaptic currents (ESPC's) of nTS neurons was augmented compared to age-matched rats raised in normoxia. These effects were unique to SH+CIH exposure as neither SH or CIH alone elicited any comparable effect on chemoafferent activity or nTS function. These data indicated that pre-treatment with neonatal SH prior to CIH exposure uniquely modified mechanisms of peripheral (CB) and central (nTS) neural function in a way that would be expected to disturb the ventilatory response to acute hypoxia.

  3. Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome.

    Directory of Open Access Journals (Sweden)

    Larisa V Lysenko

    Full Text Available Genetic alterations or pharmacological treatments affecting endocannabinoid signaling have profound effects on synaptic and neuronal properties and, under certain conditions, may improve higher brain functions. Down syndrome (DS, a developmental disorder caused by triplication of chromosome 21, is characterized by deficient cognition and inevitable development of the Alzheimer disease (AD type pathology during aging. Here we used JZL184, a selective inhibitor of monoacylglycerol lipase (MAGL, to examine the effects of chronic MAGL inhibition on the behavioral, biochemical, and synaptic properties of aged Ts65Dn mice, a genetic model of DS. In both Ts65Dn mice and their normosomic (2N controls, JZL184-treatment increased brain levels of 2-arachidonoylglycerol (2-AG and decreased levels of its metabolites such as arachidonic acid, prostaglandins PGD2, PGE2, PGFα, and PGJ2. Enhanced spontaneous locomotor activity of Ts65Dn mice was reduced by the JZL184-treatement to the levels observed in 2N animals. Deficient long-term memory was also improved, while short-term and working types of memory were unaffected. Furthermore, reduced hippocampal long-term potentiation (LTP was increased in the JZL184-treated Ts65Dn mice to the levels observed in 2N mice. Interestingly, changes in synaptic plasticity and behavior were not observed in the JZL184-treated 2N mice suggesting that the treatment specifically attenuated the defects in the trisomic animals. The JZL184-treatment also reduced the levels of Aβ40 and Aβ42, but had no effect on the levels of full length APP and BACE1 in both Ts65Dn and 2N mice. These data show that chronic MAGL inhibition improves the behavior and brain functions in a DS model suggesting that pharmacological targeting of MAGL may be considered as a perspective new approach for improving cognition in DS.

  4. Dos and don'ts for using climate information for water resource planning and management

    Science.gov (United States)

    Vano, J. A.; Clark, M. P.; Nijssen, B.; Wood, A.; Gutmann, E. D.; Arnold, J.

    2016-12-01

    Increasingly water managers and planners are being required to incorporate climate change information into their planning processes. This is generally seen as a step in the right direction. However, the continuously evolving and expanding realm of climate information can be confusing to use and easy to apply in ways the information producers never intended, and often in ways those producers might say are not viable. Additionally, advice on how various products should be used is not usually straightforward - it may require an extended dialogue between scientists and end users, which is not always feasible with current resources. While rarely is there a one-size fits all approach, there are usually preferable paths forward. To help the water resource planning and management community navigate the ever-changing climate science landscape, we present a set of guidelines for better practices when using climate information. These are divided into two categories: (1) process-based recommendations for developing an effective approach for using climate change scenarios, and (2) product-based cautions for using climate change information. This collection of dos and don'ts provides context on why certain strategies are preferable, including real-world examples. This work is intended to provide a foundation that can be built on through dialogue within and between the climate science and application communities to increase the usefulness of climate information.

  5. The Epoxidation of Limonene over the TS-1 and Ti-SBA-15 Catalysts

    Directory of Open Access Journals (Sweden)

    Agnieszka Wróblewska

    2014-11-01

    Full Text Available Limonene belongs to a group of very important intermediates used in the production of fine chemicals. This monoterpene compound can be obtained from peels of oranges or lemon which are a (biomass waste from the orange juice industry. Thus, limonene is a renewable, easy available and a relatively cheap compound. This work presents preliminary studies on the process of limonene epoxidation over zeolite type catalysts such as: TS-1 and Ti-SBA-15. In these studies methanol was used as a solvent and as an oxidizing agent a 60 wt % hydrogen peroxide solution was applied. The activity of each catalyst was investigated for four chosen temperatures (0 °C, 40 °C, 80 °C and 120 °C. The reaction time was changed from 0.5 to 24 h. For each catalyst the most beneficial conditions (the appropriate temperature and the reaction time have been established. The obtained results were compared and the most active catalyst was chosen. These studies have also shown different possible ways of limonene transformation, not only in the direction of 1,2-epoxylimonene and its corresponding diol, but also in direction of carveol, carvone and perillyl alcohol—compounds with a lot of applications. The possible mechanisms of formation of the allylic oxidation products were proposed.

  6. ISO/TS 16949:2009技术规范的沿革

    Institute of Scientific and Technical Information of China (English)

    李立陶

    2010-01-01

    @@ 一、质量管理的演进 质量管理的发展已经超过整整一个世纪,任何一个ISO/TS16949的研究工作者,首先要了解的就是质量管理领域的沿革.我们可以将其发展历程大致分为以下几个阶段: 1、操作者的质量控制.这个阶段大都是手工作业,操作者既是生产者也是质量把关者. 2、领班的质量控制.20世纪初工业革命,以机器代替手工,兴起科学管理的运动;在领班的带领及监督下执行任务,质量控制的责任在领班肩上.

  7. Sensitivity requirements of assisted BDS and GPS in specification 3GPP TS 36.171

    Science.gov (United States)

    Jin, Xiaoxi; Chen, Xin; Ying, Rendong; Yang, Genke

    2016-01-01

    With the needs of growing location-based service, a more high-performance satellite positioning technology - assisted global navigation satellite system (A-GNSS assisted-GNSS) becomes a new hotspot in area of navigation and positioning. Now, 3GPP has already provided supports for GPS, Galileo, GLONASS and QZSS, SBAS, so standardization work of introduction BDS into 3GPP organization is very imperative. In this paper, we first analysis the performance of GPS L1 C/A with assistant information, then by taking into account the difference between BDS and GPS, including the unique nature of GEO/NGEO satellites' navigation message data length and format, we design the sensitivity requirements of BDS B1 following A-GPS. The results between A-GPS and A-BDS of typical sensitivity test cases are shown in this paper, which show that the suggested sensitivity requirements satisfy the minimum performance requirements under technical specification of 3GPP TS 36.171.

  8. Study of B to X \\gamma Decays and Determination of |V_{td}/V_{ts}|

    Energy Technology Data Exchange (ETDEWEB)

    del Amo Sanchez, P.; Lees, J.P.; Poireau, V.; Prencipe, E.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Martinelli, M.; Palano, A.; Pappagallo, M.; /INFN, Bari /Bari U.; Eigen, G.; Stugu, B.; Sun, L.; /Bergen U.; Battaglia, M.; Brown, D.N.; Hooberman, B.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; Osipenkov, I.L.; Tanabe, T.; /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Indian Inst. Tech., Guwahati /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /INFN, Naples /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Southern Methodist U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U. /Victoria U. /Warwick U. /Wisconsin U., Madison

    2011-08-22

    Using a sample of 471 million B{bar B} events collected with the BABAR detector, we study the sum of seven exclusive final states B {yields} X{sub s(d){gamma}}, where X{sub s(d)} is a strange (non-strange) hadronic system with a mass of up to 2.0 GeV/c{sup 2}. After correcting for unobserved decay modes, we obtain a branching fraction for b {yields} d{gamma} of (9.2 {+-} 2.0(stat.) {+-} 2.3(syst.)) x 10{sup -6} in this mass range, and a branching fraction for b {yields} s{gamma} of (23.0 {+-} 0.8(stat.) {+-} 3.0(syst.)) x 10{sup -5} in the same mass range. We find {Beta}(b{yields}d{gamma})/{Beta}(b{yields}s{gamma}) = 0.040 {+-} 0.009(stat.) {+-} 0.010(syst.), from which we determine |V{sub td}/V{sub ts}| = 0.199 {+-} 0.022(stat.) {+-} 0.024(syst.) {+-} 0.002(th.).

  9. The epoxidation of limonene over the TS-1 and Ti-SBA-15 catalysts.

    Science.gov (United States)

    Wróblewska, Agnieszka

    2014-11-28

    Limonene belongs to a group of very important intermediates used in the production of fine chemicals. This monoterpene compound can be obtained from peels of oranges or lemon which are a (biomass) waste from the orange juice industry. Thus, limonene is a renewable, easy available and a relatively cheap compound. This work presents preliminary studies on the process of limonene epoxidation over zeolite type catalysts such as: TS-1 and Ti-SBA-15. In these studies methanol was used as a solvent and as an oxidizing agent a 60 wt % hydrogen peroxide solution was applied. The activity of each catalyst was investigated for four chosen temperatures (0 °C, 40 °C, 80 °C and 120 °C). The reaction time was changed from 0.5 to 24 h. For each catalyst the most beneficial conditions (the appropriate temperature and the reaction time) have been established. The obtained results were compared and the most active catalyst was chosen. These studies have also shown different possible ways of limonene transformation, not only in the direction of 1,2-epoxylimonene and its corresponding diol, but also in direction of carveol, carvone and perillyl alcohol-compounds with a lot of applications. The possible mechanisms of formation of the allylic oxidation products were proposed.

  10. Controller Design for Electric Power Steering System Using T-S Fuzzy Model Approach

    Institute of Scientific and Technical Information of China (English)

    Xin Li; Xue-Ping Zhao; Jie Chen

    2009-01-01

    Pressure ripples in electric power steering (EPS) systems can be caused by the phase lag between the driver's steering torque and steer angle, the nonlinear frictions, and the disturbances from road and sensor noise especially during high-frequency maneuvers. This paper investigates the use of the robust fuzzy control method for actively reducing pressure ripples for EPS systems. Remarkable progress on steering maneuverability is achieved. The EPS dynamics is described with an eight-order nonlinear state-space model and approximated by a Takagi-Sugeno (T-S) fuzzy model with time-varying delays and external disturbances. A stabilization approach is then presented for nonlinear time-delay systems through fuzzy state feedback controller in parallel distributed compensation (PDC) structure. The closed-loop stability conditions of EPS system with the fuzzy controller are parameterized in terms of the linear matrix inequality (LMI) problem. Simulations and experiments using the proposed robust fuzzy controller and traditional PID controller have been carried out for EPS systems. Both the simulation and experiment results show that the proposed fuzzy controller can reduce the torque ripples and allow us to have a good steering feeling and stable driving.

  11. MIS High-Purity Plutonium Oxide Metal Oxidation Product TS707001 (SSR123): Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Veirs, Douglas Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Stroud, Mary Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Berg, John M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Narlesky, Joshua Edward [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Worl, Laura Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Martinez, Max A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Carillo, Alex [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-09

    A high-purity plutonium dioxide material from the Material Identification and Surveillance (MIS) Program inventory has been studied with regard to gas generation and corrosion in a storage environment. Sample TS707001 represents process plutonium oxides from several metal oxidation operations as well as impure and scrap plutonium from Hanford that are currently stored in 3013 containers. After calcination to 950°C, the material contained 86.98% plutonium with no major impurities. This study followed over time, the gas pressure of a sample with nominally 0.5 wt% water in a sealed container with an internal volume scaled to 1/500th of the volume of a 3013 container. Gas compositions were measured periodically over a six year period. The maximum observed gas pressure was 138 kPa. The increase over the initial pressure of 80 kPa was primarily due to generation of nitrogen and carbon dioxide gas in the first six months. Hydrogen and oxygen were minor components of the headspace gas. At the completion of the study, the internal components of the sealed container showed signs of corrosion, including pitting.

  12. Directed evolution of a maltogenic alpha-amylase from Bacillus sp. TS-25.

    Science.gov (United States)

    Jones, Aubrey; Lamsa, Michael; Frandsen, Torben P; Spendler, Tina; Harris, Paul; Sloma, Alan; Xu, Feng; Nielsen, Jack Bech; Cherry, Joel R

    2008-04-30

    Directed evolution coupled with a high-throughput robotic screen was employed to broaden the industrial use of the maltogenic alpha-amylase Novamyl from Bacillus sp. TS-25. Wild-type Novamyl is currently used in the baking industry as an anti-staling agent in breads baked at neutral or near neutral pH. However, the enzyme is rapidly inactivated during the baking process of bread made with low pH recipes and Novamyl thus has very limited beneficial effect for this particular application. In an effort to improve the performance of Novamyl for low pH bread applications such as sourdough and rye, two error-prone PCR libraries were generated, expressed in Bacillus subtilis and screened for variants with improved thermal stability and activity under low pH conditions. Variants exhibiting improved performance were iteratively recombined using DNA shuffling to create two generations of libraries. Relative to wild-type Novamyl, a number of the resulting variants exhibited more than 10 degrees C increase in thermal stability at pH 4.5, one of which demonstrated substantial anti-staling properties in low pH breads.

  13. TS07D Empirical Geomagnetic Field Model as a Space Weather Tool

    Science.gov (United States)

    Sharp, N. M.; Stephens, G. K.; Sitnov, M. I.

    2011-12-01

    Empirical modeling and forecasting of the geomagnetic field is a key element of the space weather research. A dramatic increase in the number of data available for the terrestrial magnetosphere required a new generation of empirical models with large numbers of degrees of freedom and sophisticated data-mining techniques. A set of the corresponding data binning, fitting and visualization procedures known as the TS07D model is now available at \\url{http://geomag_field.jhuapl.edu/model/} and it is used for detailed investigation of storm-scale phenomena in the magnetosphere. However, the transformation of this research model into a practical space weather application, which implies its extensive running for validation and interaction with other space weather codes, requires its presentation in the form of a single state-of-the-art code, well documented and optimized for the highest performance. To this end, the model is implemented in the Java programming language with extensive self-sufficient library and a set of optimization tools, including multi-thread operations that assume the use of the code in multi-core computers and clusters. The results of the new code validation and optimization of its binning, fitting and visualization parts are presented as well as some examples of the processed storms are discussed.

  14. TS20聚苯颗粒外墙外保温饰面砖体系应用研究%Applied research on outer-wall external thermal insulation face files of TS20 expanded polystyrene granule

    Institute of Scientific and Technical Information of China (English)

    王治均; 黎祖庭

    2010-01-01

    TS20聚苯颗粒外墙外保温贴面砖体系广泛应用于工业与民用建筑新建及既有建筑的外墙保温.重点阐述了该体系的设计构造要点、施工要点、质量检验及工程验收要求.

  15. Application of Penicillium expansum TS 414 lipase in synthesis of biodiesel%Penicillium expansum TS 414脂肪酶催化合成生物柴油研究

    Institute of Scientific and Technical Information of China (English)

    薛建平; 苏敏; 唐良华; 张杰平

    2008-01-01

    为促进酶法生产生物柴油工艺在工业上应用,对固定化Penicillium expansum TS 414脂肪酶进行相关研究.结果表明,固定化Penicillium expansum TS 414脂肪酶具有最佳酯交换性能,在固定化酶量为20%,乙醇/大豆油摩尔比为3:1,水分含量为4%酯交换条件下,反应8 h,反应转化率可达92.6%;此外,固定化酶具有良好操作稳定性,使用8批次后,酶活仅损失17.3%.P.expansum TS 414固定化脂肪酶酯交换性能较好、价格较为低廉,可成为合成生物柴油良好催化剂.

  16. 基于TS101的SAR回波信号模拟器设计与实现%Design and Implement of SAR Echo Signal Simulator Based on TS101

    Institute of Scientific and Technical Information of China (English)

    潘勇先

    2011-01-01

    To meet the testing requirements of SAR system, a SAR echo signal simularor based on TS101 was designed.The standard compact PCI 6U board is adopted in the simujator. The human-computcr interaction is realizcd with compt7ct PCI bus tecnology. The SAR echo data can be generated according to the target echoparameters. Moreover, the simulator can output two orthogonal echo signals through link ports of TS101. The test results show that the quality of the echo signal generated by the simulator is good and can meet the requirements of the SAR system testing.%针对SAR系统的测试要求,设计了一套基于DSP处理器TS101的SAR回波模拟器.该模拟器采用标准的CPCI 6U板.利用CPCI总线技术实现人机交互,能够根据目标回波参数生成所需的SAR回波数据,并通过DSP的链路口输出两路正交回波信号.测试结果表明,该模拟器生成的回波信号质量高,实时性强,能够满足SAR系统测试的需求,具有很高的工程应用价值.

  17. 基于ARMA-TS-GARCH有限混合模型的交通数据分析%Analysis of traffic data based on ARMA-TS-GARCH finite mixture model

    Institute of Scientific and Technical Information of China (English)

    王维强; 牛振东; 曹玉娟; 赵育民; 赵堃

    2010-01-01

    基于对时间序列数据进行研究时不仅需要对它们的自回归性和周期性进行分析,而且需要对序列的方差与长期性无规则波动进行分析等问题,提出基于ARMA模型和APARCH模型的ARMA-TS-GARCH模型,并且对该模型的构造进行分析,针对洛杉矶长滩地区交通量数据进行模型参数估计和诊断检验,将此模型与GARCH和ARMA-GARCH模型进行比较.研究结果表明:ARMA-TS-GARCH模型对数据的拟合要优于ARMA模型和APARCH模型;用ARMA-TS-GARCH模型对数据集进行预测,所得结果较理想.

  18. Robust fuzzy output feedback controller for affine nonlinear systems via T-S fuzzy bilinear model: CSTR benchmark.

    Science.gov (United States)

    Hamdy, M; Hamdan, I

    2015-07-01

    In this paper, a robust H∞ fuzzy output feedback controller is designed for a class of affine nonlinear systems with disturbance via Takagi-Sugeno (T-S) fuzzy bilinear model. The parallel distributed compensation (PDC) technique is utilized to design a fuzzy controller. The stability conditions of the overall closed loop T-S fuzzy bilinear model are formulated in terms of Lyapunov function via linear matrix inequality (LMI). The control law is robustified by H∞ sense to attenuate external disturbance. Moreover, the desired controller gains can be obtained by solving a set of LMI. A continuous stirred tank reactor (CSTR), which is a benchmark problem in nonlinear process control, is discussed in detail to verify the effectiveness of the proposed approach with a comparative study.

  19. Application and Implementation of the Structured Assembly Process Planning in A Auto Enterprise Based on TS16949

    Directory of Open Access Journals (Sweden)

    Sun Jiakun

    2016-01-01

    Full Text Available Process planning is the key link that connects the product design and manufacture. In order to continually improve the effectiveness and efficiency of process planning an auto enterprise in consistent with the process management requirements of TS16949, the requirements for assembly process planning is analysed and the main problems affecting the design and production efficiency are discussed. The infrastructure of the structured process planning and management platform is constructed combing the management technology and TS16949 quality system, then the structured PPPR (product, process, plant and resourcemodel is reintegrated to analyze the relationships among the objects with the object-oriented method. In the end, with the principles of maintaining conveniently and operating practically, the assembly process planning and management system is implemented according to the characteristics of the process in the enterprise, and the main function modules of the system are described.

  20. 基于ISO/TS 16949体系的汽车行业质量管理

    Institute of Scientific and Technical Information of China (English)

    黄昊; 刘彦华; 赵永永; 菅宝柱; 宋飞飞; 吕宁

    2013-01-01

    汽车企业要发展,质量管理体系必须是最科学的,这是汽车行业不断发展的战略之一。ISO/TS 16949标准是质量管理体系建立的基础,文章对基于ISO/TS 16949标准所建立的汽车行业质量管理体系进行研究,从其产生背景着手,了解其对汽车行业发展的作用,分析其五大质量管理工具的应用。

  1. Relation between structure and Lewis acidity of Ti-Beta and TS-1 zeolites. A quantum-chemical study

    Science.gov (United States)

    Sastre, German; Corma, Avelino

    1999-03-01

    Ab-initio Hartree-Fock and density-functional-theory quantum-chemical calculations have been carried out to characterise the geometry and LUMO energies of two zeolites, Ti-Beta and TS-1. The cluster model has been used and results from classical force-field calculations have also been included for comparison and to guide the definition of the cluster boundaries. The LUMO energy, which is related to the Lewis acidity, is shown to be different for the different T-sites, and, in general, Ti-Beta shows higher Lewis acidity than TS-1. This can explain their behaviour for epoxidation of olefins as well as their catalytic properties for Lewis acid-catalysed reactions such as Meerwein-Ponndorf-Verley reactions.

  2. Stabilization for a Class of Switched Nonlinear Systems With Novel Average Dwell Time Switching by T-S Fuzzy Modeling.

    Science.gov (United States)

    Zhao, Xudong; Yin, Yunfei; Niu, Ben; Zheng, Xiaolong

    2016-08-01

    In this paper, the problem of switching stabilization for a class of switched nonlinear systems is studied by using average dwell time (ADT) switching, where the subsystems are possibly all unstable. First, a new concept of ADT is given, which is different from the traditional definition of ADT. Based on the new proposed switching signals, a sufficient condition of stabilization for switched nonlinear systems with unstable subsystems is derived. Then, the T-S fuzzy modeling approach is applied to represent the underlying nonlinear system to make the obtained condition easily verified. A novel multiple quadratic Lyapunov function approach is also proposed, by which some conditions are provided in terms of a set of linear matrix inequalities to guarantee the derived T-S fuzzy system to be asymptotically stable. Finally, a numerical example is given to demonstrate the effectiveness of our developed results.

  3. Switching off H2O2 Decomposition during TS-1 Catalysed Epoxidation via Post-Synthetic Active Site Modification

    Directory of Open Access Journals (Sweden)

    Ceri Hammond

    2015-12-01

    Full Text Available Despite its widespread use, the Lewis acidic zeolite, TS-1, still exhibits several unfavourable properties, such as excessive H2O2 decomposition, which decrease its overall performance. In this manuscript, we demonstrate that post-synthetic modification of TS-1 with aqueous NH4HF2 leads to modifications in epoxidation catalysis, which both improves the levels of epoxide selectivity obtained, and drastically minimises undesirable H2O2 decomposition. Through in situ spectroscopic study with UV-resonance enhanced Raman spectroscopy, we also observe a change in Ti site speciation, which occurs via the extraction of mononuclear [Ti(OSi4] atoms, and which may be responsible for the changes in observed activity.

  4. Cloning,expression and characterization of L-cysteine desulfhydrase gene from Pseudomonas sp.TS1138

    Institute of Scientific and Technical Information of China (English)

    YU Yangsheng; BAI Gang; LIU Chunqin; LI Yang; JIN Yongjie; YANG Wenbo

    2007-01-01

    L-cysteine desulthydrase (CD) plays an important role in L-cysteine decomposition.To identify the CD gene in Pseudomonas sp.TS 1138 and investigate its effect on the L-cysteine biosynthetic pathway,the CD gene was cloned from Pseudomonas sp.TS 1138 by polymerase chain reaction (PCR) method.The nucleotide sequence of CD gene was determined to be 1,215 bp,and its homology with other sequences encoding CD was analyzed.Then the CD gene was subcloned into pET-21a(+) vector and expressed in Escherichia coli (E.coli) by isopropyl-β-D-thiogalactopyranoside (IPTG) inducement.The recombinant CD was purified by Ni-NTA His-Bind resin,and its activity was identified by the CD activity staining.The enzymatic properties of the recombinant CD were characterized and its critical role involved in the L-cysteine biosynthetic pathway was also discussed.

  5. Deriving and Analyzing Analytical Structures of a Class of Typical Interval Type-2 TS Fuzzy Controllers.

    Science.gov (United States)

    Zhou, Haibo; Ying, Hao

    2016-06-01

    A conventional controller's explicit input-output mathematical relationship, also known as its analytical structure, is always available for analysis and design of a control system. In contrast, virtually all type-2 (T2) fuzzy controllers are treated as black-box controllers in the literature in that their analytical structures are unknown, which inhibits precise and comprehensive understanding and analysis. In this regard, a long-standing fundamental issue remains unresolved: how a T2 fuzzy set's footprint of uncertainty, a key element differentiating a T2 controller from a type-1 (T1) controller, affects a controller's analytical structure. In this paper, we describe an innovative technique for deriving analytical structures of a class of typical interval T2 (IT2) TS fuzzy controllers. This technique makes it possible to analyze the analytical structures of the controllers to reveal the role of footprints of uncertainty in shaping the structures. Specifically, we have mathematically proven that under certain conditions, the larger the footprints, the more the IT2 controllers resemble linear or piecewise linear controllers. When the footprints are at their maximum, the IT2 controllers actually become linear or piecewise linear controllers. That is to say the smaller the footprints, the more nonlinear the controllers. The most nonlinear IT2 controllers are attained at zero footprints, at which point they become T1 controllers. This finding implies that sometimes if strong nonlinearity is most important and desired, one should consider using a smaller footprint or even just a T1 fuzzy controller. This paper exemplifies the importance and value of the analytical structure approach for comprehensive analysis of T2 fuzzy controllers.

  6. TS-AMIR: a topology string alignment method for intensive rapid protein structure comparison.

    Science.gov (United States)

    Razmara, Jafar; Deris, Safaai; Parvizpour, Sepideh

    2012-02-15

    In structural biology, similarity analysis of protein structure is a crucial step in studying the relationship between proteins. Despite the considerable number of techniques that have been explored within the past two decades, the development of new alternative methods is still an active research area due to the need for high performance tools. In this paper, we present TS-AMIR, a Topology String Alignment Method for Intensive Rapid comparison of protein structures. The proposed method works in two stages: In the first stage, the method generates a topology string based on the geometric details of secondary structure elements, and then, utilizes an n-gram modelling technique over entropy concept to capture similarities in these strings. This initial correspondence map between secondary structure elements is submitted to the second stage in order to obtain the alignment at the residue level. Applying the Kabsch method, a heuristic step-by-step algorithm is adopted in the second stage to align the residues, resulting in an optimal rotation matrix and minimized RMSD. The performance of the method was assessed in different information retrieval tests and the results were compared with those of CE and TM-align, representing two geometrical tools, and YAKUSA, 3D-BLAST and SARST as three representatives of linear encoding schemes. It is shown that the method obtains a high running speed similar to that of the linear encoding schemes. In addition, the method runs about 800 and 7200 times faster than TM-align and CE respectively, while maintaining a competitive accuracy with TM-align and CE. The experimental results demonstrate that linear encoding techniques are capable of reaching the same high degree of accuracy as that achieved by geometrical methods, while generally running hundreds of times faster than conventional programs.

  7. TS-AMIR: a topology string alignment method for intensive rapid protein structure comparison

    Directory of Open Access Journals (Sweden)

    Razmara Jafar

    2012-02-01

    Full Text Available Abstract Background In structural biology, similarity analysis of protein structure is a crucial step in studying the relationship between proteins. Despite the considerable number of techniques that have been explored within the past two decades, the development of new alternative methods is still an active research area due to the need for high performance tools. Results In this paper, we present TS-AMIR, a Topology String Alignment Method for Intensive Rapid comparison of protein structures. The proposed method works in two stages: In the first stage, the method generates a topology string based on the geometric details of secondary structure elements, and then, utilizes an n-gram modelling technique over entropy concept to capture similarities in these strings. This initial correspondence map between secondary structure elements is submitted to the second stage in order to obtain the alignment at the residue level. Applying the Kabsch method, a heuristic step-by-step algorithm is adopted in the second stage to align the residues, resulting in an optimal rotation matrix and minimized RMSD. The performance of the method was assessed in different information retrieval tests and the results were compared with those of CE and TM-align, representing two geometrical tools, and YAKUSA, 3D-BLAST and SARST as three representatives of linear encoding schemes. It is shown that the method obtains a high running speed similar to that of the linear encoding schemes. In addition, the method runs about 800 and 7200 times faster than TM-align and CE respectively, while maintaining a competitive accuracy with TM-align and CE. Conclusions The experimental results demonstrate that linear encoding techniques are capable of reaching the same high degree of accuracy as that achieved by geometrical methods, while generally running hundreds of times faster than conventional programs.

  8. Design and baseline characteristics of the Short bouTs of Exercise for Preschoolers (STEP study

    Directory of Open Access Journals (Sweden)

    Alhassan Sofiya

    2012-08-01

    Full Text Available Abstract Background Most preschool centers provide two 30-min sessions of gross-motor/outdoor playtime per preschool day. Within this time frame, children accumulate most of their activity within the first 10 min. This paper describes the design and baseline participant characteristics of the Short bouTs of Exercise for Preschoolers (STEP study. The STEP study is a cluster randomized controlled study designed to examine the effects of short bouts of structured physical activity (SBS-PA implemented within the classroom setting as part of designated gross-motor playtime on during-school physical activity (PA in preschoolers. Methods/Design Ten preschool centers serving low-income families were randomized into SBS-PA versus unstructured PA (UPA. SBS-PA schools were asked to implement age-appropriate 10 min structured PA routines within the classroom setting, twice daily, followed by 20 min of usual unstructured playtime. UPA intervention consisted of 30 min of supervised unstructured free playtime twice daily. Interventions were implemented during the morning and afternoon designated gross-motor playtime for 30 min/session, five days/week for six months. Outcome measures were between group difference in during-preschool PA (accelerometers and direct observation over six-months. Ten preschool centers, representing 34 classrooms and 315 children, enrolled in the study. The average age and BMI percentile for the participants was 4.1 ± 0.8 years and 69th percentile, respectively. Participants spent 74% and 6% of their preschool day engaged in sedentary and MVPA, respectively. Discussion Results from the STEP intervention could provide evidence that a PA policy that exposes preschoolers to shorter bouts of structured PA throughout the preschool day could potentially increase preschoolers’ PA levels. Trial registration Clinicaltrials.gov, NCT01588392

  9. THE STATE OF THE WATER IN BRAIN TISSUE IN PRESENCE OF TS-100 NANOPARTICLES

    Directory of Open Access Journals (Sweden)

    T. V.

    2015-12-01

    Full Text Available By the method of low-temperature 1Н NMR spectroscopy the structure of the hydrate layers of water associated with brain cells, the changes of these parameters during necrotic lesions (stroke and in the presence of trifluoroacetic acid, which allows differentiating intracellular water clusters according to their ability to dissolve the acid, were studied. Also the impact of silica TS-100 nanoparticles on the state of water in brain tissue, namely on the water binding parameters in the air and in the presence of a weakly polar solvent was considered. The distributions by the radii and change of Gibbs free energy for clusters of strongly bound interfacial water were obtained. It was shown that the hydration properties of the native brain tissue differ from the hydration properties of necrotic damaged tissue by the structure of weakly bound water clusters. In intact tissue all the water is associated and is a part of clusters and domains, most of which have a radii R = 2 and 20 nm. The media with chloroform stabilizes water polyassociates with the radius up to R = 100 nm and trifluoroacetic acid stabilizes water polyassociates with radii R = 7–20 nm. It was found that the partial dehydration of the investigated tissue samples is accompanied by decreasing of weakly bound water amount and some increasing of strongly bound water that indicates a change of molecular interactions between the components of cells-nanoparticles composite system. The ischemic necrosis area presence leads to a decrease of water binding due to the average size water polyassociates increasing. This effect is observed both in air and in a weakly polar organic solvent medium (deuterochloroform.

  10. BF-PSO-TS: Hybrid Heuristic Algorithms for Optimizing Task Schedulingon Cloud Computing Environment

    Directory of Open Access Journals (Sweden)

    Hussin M. Alkhashai

    2016-06-01

    Full Text Available Task Scheduling is a major problem in Cloud computing because the cloud provider has to serve many users. Also, a good scheduling algorithm helps in the proper and efficient utilization of the resources. So, task scheduling is considered as one of the major issues on the Cloud computing systems. The objective of this paper is to assign the tasks to multiple computing resources. Consequently, the total cost of execution is to be minimum and load to be shared between these computing resources. Therefore, two hybrid algorithms based on Particle Swarm Optimization (PSO have been introduced to schedule the tasks; Best-Fit-PSO (BFPSO and PSO-Tabu Search (PSOTS. According to BFPSO algorithm, Best-Fit (BF algorithm has been merged into the PSO algorithm to improve the performance. The main principle of the modified BFSOP algorithm is that BF algorithm is used to generate the initial population of the standard PSO algorithm instead of being initiated randomly. According to the proposed PSOTS algorithm, the Tabu-Search (TS has been used to improve the local research by avoiding the trap of the local optimality which could be occurred using the standard PSO algorithm. The two proposed algorithms (i.e., BFPSO and PSOTS have been implemented using Cloudsim and evaluated comparing to the standard PSO algorithm using five problems with different number of independent tasks and resources. The performance parameters have been considered are the execution time (Makspan, cost, and resources utilization. The implementation results prove that the proposed hybrid algorithms (i.e., BFPSO, PSOTS outperform the standard PSO algorithm.

  11. tsORFdb: theoretical small open reading frames (ORFs) database and massProphet: peptide mass fingerprinting (PMF) tool for unknown small functional ORFs.

    Science.gov (United States)

    Heo, Hyoung-Sam; Lee, Sanghyuk; Kim, Ji Min; Choi, Yeon Ja; Chung, Hae Young; Oh, S June

    2010-06-18

    Peptide mass fingerprinting (PMF) has become one of the most widely used methods for rapid identification of proteins in proteomics research. Many peaks, however, remain unassigned after PMF analysis, partly because of post-translational modification and the limited scope of protein sequences. Almost all PMF tools employ only known or predicted protein sequences and do not include open reading frames (ORFs) in the genome, which eliminates the chance of finding novel functional peptides. Unlike most tools that search protein sequences from known coding sequences, the tool we developed uses a database for theoretical small ORFs (tsORFs) and a PMF application using a tsORFs database (tsORFdb). The tsORFdb is a database for ORFeome that encompasses all potential tsORFs derived from whole genome sequences as well as the predicted ones. The massProphet system tries to extend the search scope to include the ORFeome using the tsORFdb. The tsORFdb and massProphet should be useful for proteomics research to give information about unknown small ORFs as well as predicted and registered proteins.

  12. Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.

    Science.gov (United States)

    Shimohata, Atsushi; Ishihara, Keiichi; Hattori, Satoko; Miyamoto, Hiroyuki; Morishita, Hiromasa; Ornthanalai, Guy; Raveau, Matthieu; Ebrahim, Abdul Shukkur; Amano, Kenji; Yamada, Kazuyuki; Sago, Haruhiko; Akiba, Satoshi; Mataga, Nobuko; Murphy, Niall P; Miyakawa, Tsuyoshi; Yamakawa, Kazuhiro

    2017-07-01

    Ts1Cje mice have a segmental trisomy of chromosome 16 that is orthologous to human chromosome 21 and display Down syndrome-like cognitive impairments. Despite the occurrence of affective and emotional impairments in patients with Down syndrome, these parameters are poorly documented in Down syndrome mouse models, including Ts1Cje mice. Here, we conducted comprehensive behavioral analyses, including anxiety-, sociability-, and depression-related tasks, and biochemical analyses of monoamines and their metabolites in Ts1Cje mice. Ts1Cje mice showed enhanced locomotor activity in novel environments and increased social contact with unfamiliar partners when compared with wild-type littermates, but a significantly lower activity in familiar environments. Ts1Cje mice also exhibited some signs of decreased depression like-behavior. Furthermore, Ts1Cje mice showed monoamine abnormalities, including increased extracellular dopamine and serotonin, and enhanced catabolism in the striatum and ventral forebrain. This study constitutes the first report of deviated monoamine metabolism that may help explain the basis for abnormal behaviors, including the environmental stimuli-triggered hyperactivity, increased sociability and decreased depression-like behavior in Ts1Cje mice. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Altered expression of neuropeptides in the primary somatosensory cortex of the Down syndrome model Ts65Dn.

    Science.gov (United States)

    Hernández, Samuel; Gilabert-Juan, Javier; Blasco-Ibáñez, José Miguel; Crespo, Carlos; Nácher, Juan; Varea, Emilio

    2012-02-01

    Down syndrome is the most common genetic disorder associated with mental retardation. Subjects and mice models for Down syndrome (such as Ts65Dn) show defects in the formation of neuronal networks in both the hippocampus and the cerebral cortex. The principal neurons display alterations in the morphology, density and distribution of dendritic spines in the cortex as well as in the hippocampus. Several evidences point to the possibility that the atrophy observed in principal neurons could be mediated by changes in their inhibitory inputs and, in fact, an imbalance between excitation and inhibition has been observed in Ts65Dn mice in these regions, which are crucial for learning and information processing. These animals have an increased density of interneurons in the primary somatosensory cortex, especially of those expressing calretinin and calbindin D-28k. Here, we have analysed the expression and distribution of several neuropeptides in the primary somatosensory cortex of Ts65Dn mice in order to investigate whether these subpopulations of interneurons are affected. We have observed an increase in the total density of somatostatin expressing interneurons and of those expressing VIP in layer IV in Ts65Dn mice. The typology of the somatostatin and VIP interneurons was unaltered as attested by the pattern of co-expression with other markers. Somatostatin immunoreactive neurons co-express mainly D-28k calbindin and VIP expressing interneurons maintain its pattern of co-expression with calcium binding proteins. These alterations, in case they were also present in subjects with Down syndrome, could be related to their impairment in cognitive profile and could be involved in the neurological defects observed in this disorder.

  14. Guaranteed Cost Control for Uncertain Nonlinear Time-Delay Neutral Systems Based on T-S Fuzzy Model

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The problem of guaranteed cost fuzzy controller is studied for a class of nonlinear time-delay neutral systems with norm-bounded uncertainty based on T-S model. The sufficient conditions are first derived for the existence of guaranteed cost fuzzy controllers. These sufficient conditions are equivalent to a kind of linear matrix inequalities. Furthermore, a convex optimization problem with LMI constraints is formulated to design the optimal guaranteed cost controller.

  15. ISO/TS 16949认证授权工作取得实质进展

    Institute of Scientific and Technical Information of China (English)

    徐有刚

    2004-01-01

    @@ 北京九鼎国联汽车管理体系认证有限责任公司(CASC)自成立以来,得到了国家认监委、认可机构及成员单位等多方面的支持,在ISO/TS 16949认证资格的授权方面也取得了实质性的进展.

  16. T-S Fuzzy Model Based Control Strategy for the Networked Suspension Control System of Maglev Train

    OpenAIRE

    2015-01-01

    The control problem for the networked suspension control system of maglev train with random induced time delay and packet dropouts is investigated. First, Takagi-Sugeno (T-S) fuzzy models are utilized to represent the discrete-time nonlinear networked suspension control system, and the parameters uncertainties of the nonlinear model have also been taken into account. The controllers take the form of parallel distributed compensation. Then, a sufficient condition for the stability of the netwo...

  17. LHC optics determination with proton tracks measured in the CT-PPS detectors in 2016, before TS2

    CERN Document Server

    Nemes, F

    2017-01-01

    Novel optics estimation methods have been developed for the CMS-TOTEM Precision Proton Spectrometer (CT-PPS), in order to determine the horizontal dispersion function $D_{x}$ and the orbit between IP5 and the Roman Pot detectors. The tools have been successfully applied at $\\sqrt{s} = $13 TeV collision energy and $\\beta^{*} = $0.4 m optics with $\\alpha = 370\\,\\mu$rad horizontal crossing angle (settings valid in 2016 before Technical Stop 2 - TS2).

  18. Robust H∞ Control of Uncertain T-S Fuzzy Time-Delay System: A Delay Decomposition Approach

    OpenAIRE

    Cheng Gong; Chunsong Han

    2013-01-01

    This paper is concerned with the problem of robust H∞ control for a class of uncertain time-delay fuzzy systems with norm-bounded parameter uncertainties. By utilizing the instrumental idea of delay decomposition, the decomposed Lyapunov-Krasovskii functional is introduced to uncertain T-S fuzzy system, and some delay-dependent conditions for the existence of robust controller are formulated in the form of linear matrix inequalities (LMIs). When these LMIs are feasible, a controller is presen...

  19. Fluorescent immortalized human adipose derived stromal cells (hASCs-TS/GFP+) for studying cell drug delivery mediated by microvesicles.

    Science.gov (United States)

    Coccè, Valentina; Balducci, Luigi; Falchetti, Maria Laura; Pascucci, Luisa; Ciusani, Emilio; Brini, Anna Teresa; Sisto, Francesca; Piovani, Giovanna; Alessandri, Giulio; Parati, Eugenio; Cabeza, Laura; Pessina, Augusto

    2017-03-27

    A new tool for the drug delivery is based on the use of Mesenchymal Stromal Cells (MSCs) loaded in vitro with anti-cancer drugs. Unfortunately, the restricted lifespan of MSCs represents a significant limitation to produce them in high amounts and for long time studies. Immortalized MSCs from adipose tissue (hASC) have been generated as good source of cells with stable features. These cells could improve the development of standardized procedures for both in vitro and preclinical studies. Furthermore they facilitate procedures for preparing large amounts of secretome containing microvesicles (MVs). We used human adipose tissue derived MSCs immortalized with hTERT+SV40 (TS) genes and transfected with GFP (hASCs-TS/GFP+). This line was investigate for its ability to uptake and release anticancer drugs. Microvesicles associated to paclitaxel (MVs/PTX) were isolated, quantified, and tested on pancreatic cancer cells. The line hASCs-TS/GFP+ maintained the main mesenchymal characters and was able to uptake and release, in active form, both paclitaxel and gemcitabine. From paclitaxel loaded hASCs-TS/GFP+ cells were isolated microvesicles in sufficient amount to inhibit "in vitro" the proliferation of pancreatic tumor cells. Our study suggests that human immortalized MSCs could be used for a large scale production of cells for mediated drug delivery. Moreover, the secretion of drug-associated MVs could represent a new way for producing new drug formulation by "biogenesis". In the context of the "advanced cell therapy procedure", the MVs/PTX production would be less resource and time consuming and it could possibly contribute to simplification of GMP procedures. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  20. A route to hydroxylfluorenes: TsOH-mediated condensation reactions of 1,3-diketones with propargylic alcohols

    KAUST Repository

    Yao, Liangfeng

    2012-01-01

    An efficient method of preparing hydroxylfluorenes by TsOH-mediated tandem alkylation/rearrangements of propargylic alcohols with 1,3-diketones is described. These reactions are accomplished in moderate to good yields under mild conditions to offer a straightforward and convenient one step synthetic route to hydroxylfluorene derivatives through a plausible mechanism involving a sequence of dehydration, addition, rearrangement and aromatization. This journal is © The Royal Society of Chemistry 2012.

  1. Assessing Apoptosis Gene Expression Profiling with a PCR Array in the Hippocampus of Ts65Dn Mice

    Directory of Open Access Journals (Sweden)

    Bin Yu

    2015-01-01

    Full Text Available It is well known that Down syndrome (DS is a condition in which extra genetic material causes delays in the way a child develops, both mentally and physically. Intellectual disability is the foremost and most debilitating trait, which caused loss of cognitive abilities and the development of early onset Alzheimer’s disease (AD. Ts65Dn mice were used in this study. We isolated the hippocampus. First, we used transmission scanning electron microscopy to directly observe the hippocampus and confirm if apoptosis had occurred. Second, we customized a PCR array with 53 genes, including several important genes related to cell apoptosis. Gene expression was detected by RT-PCR. There were varying degrees of changes characteristic of apoptosis in the hippocampus of Ts65Dn mice, which mainly included the following: nuclear membrane thinning, unevenly distributed chromosomes, the production of chromatin crescents, and pyknosis of the nuclei with some nuclear fragmentation. Meanwhile, three genes (API5, AIFM1, and NFκB1 showed changes of expression in the hippocampus of Ts65Dn mice compared with normal mice. Only NFκB1 expression was significantly increased, while the expressions of API5 and AIFM1 were notably decreased. The fold changes in the expression of API5, AIFM1, and NFκB1 were 11.55, 5.94, and 3.11, respectively. However, some well-known genes related to cell apoptosis, such as the caspase family, Bcl-2, Bad, Bid, Fas, and TNF, did not show changes in expression levels. The genes we found which were differentially expressed in the hippocampus of Ts65Dn mice may be closely related to cell apoptosis. PCR array technology can assist in the screening and identification of genes involved in apoptosis.

  2. Cu exchanged microporous titanium silicalite (TS-1) coated on polycrystalline mullite fibres as catalyst for the CO and NO conversion

    Energy Technology Data Exchange (ETDEWEB)

    Petrov, L.; Soria, J.; Cataluna, R. [Instituto de Catalisis y Petroleoquimica, CSIC, Campus Universitario de Cantoblanco, Madrid, (Spain); Dimitrov, L.; Spasov, L.; Dimitrov, P. [Institute of Catalysis, Bulgarian Academy of Sciences, Sofia (Bulgaria)

    1996-02-29

    A surface coated with TS-1 mullite fibre was prepared. From this material, a copper containing zeolite catalyst was produced by ion exchange, that was more active for carbon monoxide oxidation reaction than the noble metal containing supported catalysts. By combining the copper containing catalyst with rhodium and ceria, a catalyst for carbon monoxide oxidation and nitric oxide reduction reactions, superior in activity to noble metals supported catalysts were prepared

  3. LHC optics determination with proton tracks measured in the CT-PPS detectors in 2016, before TS2

    CERN Document Server

    Nemes, F

    2017-01-01

    Novel optics estimation methods have been developed for the CMS-TOTEM Precision Proton Spectrometer (CT-PPS), in order to determine the horizontal dispersion function $D_{x}$ and the orbit between IP5 and the Roman Pot detectors. The tools have been successfully applied at $\\sqrt{s} = $13 TeV collision energy and $\\beta^{*} = $0.4 m optics with $\\alpha = 370\\,\\mu$rad horizontal crossing angle (settings valid in 2016 before Technical Stop 2 - TS2).

  4. Human liver estrone (E1), Estradiol (E2) and dehydroepiandrosterone (DHEA) sulfotransferases (STs): Comparison with thermostable (TS) and thermolabile (TL) phenol sulfotransferase (PST) activities

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez, J.S.; Watson, R.W.G.; Weinshilboum, R.M. (Mayo Clinic/Mayo Foundation, Rochester, MN (United States))

    1991-03-11

    Sulfation plays an important role in the metabolism of E1, E2 and DHEA in humans. The relationship between the enzymes that catalyze the sulfation of E1, E2 and DHEA and TS and TL PST is unclear. The authors compared thermal stability, sensitivity to inhibition by 2,6-dichloro-4-nitrophenol (DCNP) and individual variation in the regulation of these steroid ST activities with those of TS PST and TL PST in the human liver. E2 ST and TS PST had very similar thermal stabilities. The thermal inactivation profile of E1 ST suggested that this activity might be related to both DHEA ST and TS PST. DCNP inhibition studies also showed similar profiles for E2 ST and TS PST, with a small resistant component for E2 ST. A multiphasic profile for DCNP inhibition of E1 ST activity was found. Finally, studies performed with human liver sample showed significant correlations between E2 ST and TS PST, E1 ST and DHEA ST, E2 St and E1 ST, and, to a lesser degree, between E1 ST and TS PST and E2 ST and DHEA ST. TL PST was not correlated significantly with any of the other activities. These results suggest that the sulfation of E2 in human liver is catalyzed predominantly by TS PST, although DHEA ST may also play a role. Their results also suggest that the sulfation of E1 is catalyzed by DHEA ST and by TS PST, although other ST(s) could also be involved.

  5. Oral Vaccination with Attenuated Salmonella typhimurium-Delivered TsPmy DNA Vaccine Elicits Protective Immunity against Trichinella spiralis in BALB/c Mice

    Science.gov (United States)

    Wang, Lei; Wang, Xiaohuan; Bi, Kuo; Sun, Ximeng; Yang, Jing; Gu, Yuan; Huang, Jingjing; Zhan, Bin; Zhu, Xinping

    2016-01-01

    Background Our previous studies showed that Trichinella spiralis paramyosin (TsPmy) is an immunomodulatory protein that inhibits complement C1q and C8/C9 to evade host complement attack. Vaccination with recombinant TsPmy protein induced protective immunity against T. spiralis larval challenge. Due to the difficulty in producing TsPmy as a soluble recombinant protein, we prepared a DNA vaccine as an alternative approach in order to elicit a robust immunity against Trichinella infection. Methods and Findings The full-length TsPmy coding DNA was cloned into the eukaryotic expression plasmid pVAX1, and the recombinant pVAX1/TsPmy was transformed into attenuated Salmonella typhimurium strain SL7207. Oral vaccination of mice with this attenuated Salmonella-delivered TsPmy DNA vaccine elicited a significant mucosal sIgA response in the intestine and a systemic IgG antibody response with IgG2a as the predominant subclass. Cytokine analysis also showed a significant increase in the Th1 (IFN-γ, IL-2) and Th2 (IL-4, 5, 6, 10) responses in lymphocytes from the spleen and MLNs of immunized mice upon stimulation with TsPmy protein. The expression of the homing receptors CCR9/CCR10 on antibody secreting B cells may be related to the translocation of IgA-secreted B cells to local intestinal mucosa. The mice immunized with Salmonella-delivered TsPmy DNA vaccine produced a significant 44.8% reduction in adult worm and a 46.6% reduction in muscle larvae after challenge with T. spiralis larvae. Conclusion Our results demonstrated that oral vaccination with TsPmy DNA delivered by live attenuated S. typhimurium elicited a significant local IgA response and a mixed Th1/Th2 immune response that elicited a significant protection against T. spiralis infection in mice. PMID:27589591

  6. Relationship Between the DPD and TS mRNA Expression and the Response to S-1-Based Chemotherapy and Prognosis in Patients with Advanced Gastric Cancer.

    Science.gov (United States)

    Shen, Xiao-Ming; Zhou, Chong; Lian, Lian; Li, Li-Qun; Li, Wei; Tao, Min

    2015-04-01

    The aim was to determine changes in dihydropyrimidine dehydrogenase (DPD) and thymidylate synthase (TS) mRNAs in the blood of advanced gastric cancer (AGC) patients to see whether these enzymes affected the patients' response to S-1-based chemotherapy and prognosis. For this purpose, pretreatment DPD/TS mRNA expressions were determined in 40 AGC patients using RT-PCR. The patients were then administered with S-1-based regimen (S-1 + cisplatin) and toxicities were recorded. The relationship between the DPD/TS mRNA expressions and the chemotherapy response, drug resistance, and prognosis was analyzed. The data show that DPD mRNA expression correlated significantly with Lauren type while TS mRNA expression correlated with distant metastasis. Patients with higher DPD and/or TS mRNA expression(s) showed poor response, while those with low DPD mRNA expression showed better response to the chemotherapy. Pooled analysis showed that the patients with low DPD/TS mRNA expressions had better therapeutic response. The incidence of bone marrow suppression, diarrhea, and oral mucositis was high in patients with low DPD mRNA expression. Median overall survival (OS) in 40 patients was 13.5 months. It was 17 months for low and 10 months for high DPD (P = 0.044) and TS mRNA expression (P = 0.047). Pooled analysis showed that the patients with both low DPD/TS mRNA expressions had longer OS (P = 0.001). In conclusion, the detection of DPD and/or TS mRNA expression can be used to predict the response to S-1-based chemotherapy, drug resistance, and prognosis in AGC patients as well as to help guide the individualized treatment of gastric cancer.

  7. The polysaccharide from Tamarindus indica (TS-polysaccharide) protects cultured corneal-derived cells (SIRC cells) from ultraviolet rays.

    Science.gov (United States)

    Raimondi, L; Lodovici, M; Guglielmi, F; Banchelli, G; Ciuffi, M; Boldrini, E; Pirisino, R

    2003-03-01

    The aim of this work was to investigate the possible protective effect of a new viscosising agent, TS-polysaccharide, on corneal-derived cells (SIRC) exposed to ultraviolet-B rays. To verify this, SIRC cells were first exposed, in the absence or in the presence of TS-polysaccharide (1% w/v), for 9 s at the UV-B source and then post-incubated for 45 min at 37 degrees C. After this period the hydrogen peroxide (H(2)O(2)) accumulated in the medium and the concentration of 8-hydroxy-2'-deoxy-guanosine (8-OHdG) in cell DNA was measured. In addition, the amount of (3)H-methyl-thymidine incorporated in cellular DNA was evaluated after 18 h from irradiation. Our results show that cells exposed to UV-B rays accumulate H(2)O(2), and have higher levels of 8OHdG and a lower amount of (3)H-methyl-thymidine incorporated in DNA than control cells. In the presence of TS-polysaccharide, the H(2)O(2) and 8-OHdG accumulation, and the (3)H-methyl-thymidine incorporation were significantly reduced with respect to the values measured in cells exposed in the absence of the polysaccharide. We propose a protective role of the polysaccharide in reducing UV-B derived DNA damage to eye cells. This finding could be of some clinical importance when the polysaccharide is used as a delivery system for ophthalmic preparations.

  8. Deletion analysis of the C-terminal region of the alpha-amylase of Bacillus sp. strain TS-23.

    Science.gov (United States)

    Lo, Huei-Fen; Lin, Long-Liu; Chiang, Wen-Ying; Chie, Meng-Chun; Hsu, Wen-Hwei; Chang, Chen-Tien

    2002-08-01

    The alpha-amylase from Bacillus sp. strain TS-23 is a secreted starch hydrolase with a domain organization similar to that of other microbial alpha-amylases and an additional functionally unknown domain (amino acids 517-613) in the C-terminal region. By sequence comparison, we found that this latter domain contained a sequence motif typical for raw-starch binding. To investigate the functional role of the C-terminal region of the alpha-amylase of Bacillus sp. strain TS-23, four His(6)-tagged mutants with extensive deletions in this region were constructed and expressed in Escherichia coli. SDS-PAGE and activity staining analyses showed that the N- and C-terminally truncated alpha-amylases had molecular masses of approximately 65, 58, 54, and 49 kDa. Progressive loss of raw-starch-binding activity occurred upon removal of C-terminal amino acid residues, indicating the requirement for the entire region in formation of a functional starch-binding domain. Up to 98 amino acids from the C-terminal end of the alpha-amylase could be deleted without significant effect on the raw-starch hydrolytic activity or thermal stability. Furthermore, the active mutants hydrolyzed raw corn starch to produce maltopentaose as the main product, suggesting that the raw-starch hydrolytic activity of the Bacillus sp. strain TS-23 alpha-amylase is functional and independent from the starch-binding domain.

  9. Advanced Turbine Technology Applications Project (ATTAP) and Hybrid Vehicle Turbine Engine Technology Support project (HVTE-TS): Final summary report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    This final technical report was prepared by Rolls-Royce Allison summarizing the multiyear activities of the Advanced Turbine Technology Applications Project (ATTAP) and the Hybrid Vehicle Turbine Engine Technology Support (HVTE-TS) project. The ATTAP program was initiated in October 1987 and continued through 1993 under sponsorship of the US Department of Energy (DOE), Energy Conservation and Renewable Energy, Office of Transportation Technologies, Propulsion Systems, Advanced Propulsion Division. ATTAP was intended to advance the technological readiness of the automotive ceramic gas turbine engine. The target application was the prime power unit coupled to conventional transmissions and powertrains. During the early 1990s, hybrid electric powered automotive propulsion systems became the focus of development and demonstration efforts by the US auto industry and the Department of energy. Thus in 1994, the original ATTAP technology focus was redirected to meet the needs of advanced gas turbine electric generator sets. As a result, the program was restructured to provide the required hybrid vehicle turbine engine technology support and the project renamed HVTE-TS. The overall objective of the combined ATTAP and HVTE-TS projects was to develop and demonstrate structural ceramic components that have the potential for competitive automotive engine life cycle cost and for operating 3,500 hr in an advanced high temperature turbine engine environment. This report describes materials characterization and ceramic component development, ceramic components, hot gasifier rig testing, test-bed engine testing, combustion development, insulation development, and regenerator system development. 130 figs., 12 tabs.

  10. Penicillium expansum TS414脂肪酶催化合成生物柴油的研究

    Institute of Scientific and Technical Information of China (English)

    薛建平; 苏敏; 唐良华; 张杰平

    2008-01-01

    为了促进酶法生产生物柴油工艺在工业上的应用,对固定化Penicillium expansum TS414脂肪酶进行了相关研究.结果表明,固定化Penicillium expansumTS414脂肪酶具有最佳的酯交换性能.在固定化酶量为20%、乙醇/大豆油摩尔比为3:1、水分含量为4%的酯交换条件下,反应8h,反应转化率可达92.6%.此外,固定化酶具有良好的操作稳定性-使用8批次后,酶活仅损失17.3%.P.expansum TS414固定化脂肪酶的酯交换性能较好、价格较为低廉,可成为合成生物柴油的良好催化剂.

  11. Robust Optimal Output Tracking Control of A Midwater Trawl System Based on T-S Fuzzy Nonlinear Model

    Institute of Scientific and Technical Information of China (English)

    ZHOU Hua; CHEN Ying-long; YANG Hua-yong

    2013-01-01

    A robust optimal output tracking control method for a midwater trawl system is investigated based on T-S fuzzy nonlinear model.A simplified nonlinear mathematical model is first employed to represent a midwater trawl system,and then a T-S fuzzy model is adopted to approximate the nonlinear system.Since the strong nonlinearities and the external disturbance of the trawling system,a mixed H2/H∞ fuzzy output tracking control strategy via T-S fuzzy system is proposed to regulate the trawl depth to follow a desired trajectory.The trawl depth can be regulated by adjusting the winch velocity automatically and the tracking error can be minimized according to the robust optimal criterion.In order to validate the proposed control method,a computer simulation is conducted.The simulation results indicate that the proposed fuzzy robust optimal controller make the trawl net rapidly follow the desired trajectory under the model uncertainties and the external disturbance caused by wave and current.

  12. Observer-Based Non-PDC Control for Networked T-S Fuzzy Systems With an Event-Triggered Communication.

    Science.gov (United States)

    Peng, Chen; Ma, Shaodong; Xie, Xiangpeng

    2017-02-07

    This paper addresses the problem of an event-triggered non-parallel distribution compensation (PDC) control for networked Takagi-Sugeno (T-S) fuzzy systems, under consideration of the limited data transmission bandwidth and the imperfect premise matching membership functions. First, a unified event-triggered T-S fuzzy model is provided, in which: 1) a fuzzy observer with the imperfect premise matching is constructed to estimate the unmeasurable states of the studied system; 2) a fuzzy controller is designed following the same premise as the observer; and 3) an output-based event-triggering transmission scheme is designed to economize the restricted network resources. Different from the traditional PDC method, the synchronous premise between the fuzzy observer and the T-S fuzzy system are no longer needed in this paper. Second, by use of Lyapunov theory, a stability criterion and a stabilization condition are obtained for ensuring asymptotically stable of the studied system. On account of the imperfect premise matching conditions are well considered in the derivation of the above criteria, less conservation can be expected to enhance the design flexibility. Compared with some existing emulation-based methods, the controller gains are no longer required to be known a priori. Finally, the availability of proposed non-PDC design scheme is illustrated by the backing-up control of a truck-trailer system.

  13. Survey of the TS-ECE Discrepancy and recent investigations in ICRF heated plasmas at Alcator C-Mod

    Directory of Open Access Journals (Sweden)

    Reinke M. L.

    2012-09-01

    Full Text Available This paper reports on a new investigation of the long-standing, unresolved discrepancy between Thomson Scattering (TS and Electron Cyclotron Emission (ECE measurements of electron temperature in high temperature tokamak plasmas. At the Alcator C-Mod tokamak, ion cyclotron range of frequency (ICRF heating is used to produce high temperature conditions where the TS- ECE discrepancy, as observed in the past at JET and TFTR, should appear. Plasmas with Te(0 up to 8 keV are obtained using three different heating scenarios: Ion Cyclotron Resonance Heating (ICRH, ICRF mode conversion heating and a combination of the two heating methods. This is done in order to explore the hypothesis that ICRH-generated fast ions may be related to the discrepancy. In all high temperature cases at C-Mod, we find no evidence for the type of discrepancy reported at JET and TFTR. Here we present the C-Mod results along with a summary of past work on the TS-ECE discrepancy.

  14. [TS-1 therapy via intestinal catheter used for tube feeding in a patient with gastric cancer after total gastrectomy].

    Science.gov (United States)

    Hagiike, Masanobu; Tsuboi, Yuka; Akamoto, Shintaro; Yachida, Shinichi; Izuishi, Kunihiko; Karasawa, Yukihiko; Goda, Fuminori; Okada, Setsuo; Usuki, Hisashi; Maeta, Hajime

    2005-07-01

    The patient was a 76-year-old man having gastric cancer with peritoneal dissemination. He underwent total gastrectomy for resection of the primary tumor and improvement of the oral intake. He developed ileus and peritonitis after the surgery, which necessitated two additional operations. An intestinal stoma was thus therefore created using a catheter for tube feeding, and tube feeding was initiated after the surgery. Nutrients, as well as TS-1 (taken out of the capsule; 80 mg/day) were administered via the catheter for tube feeding. This therapy was followed by a reduction in tumor marker levels and improvement of the patient's performance status (PS), after which the patient could be discharged. He stayed at home for about 8 months, with a much-improved quality of life during this period. We concluded that the TS-1 therapy via the catheter used for alimentation was effective for the treatment of cancer in this patient. We report our experience with this case, in which tube feeding became necessary after total gastrectomy, but administration of TS-1 via the same catheter used for alimentation improved the patient's PS and made it possible for him to receive chemotherapy at home.

  15. Facile Synthesis of Yolk/Core-Shell Structured TS-1@Mesosilica Composites for Enhanced Hydroxylation of Phenol

    KAUST Repository

    Zou, Houbing

    2015-12-14

    © 2015 by the authors. In the current work, we developed a facile synthesis of yolk/core-shell structured TS-1@mesosilica composites and studied their catalytic performances in the hydroxylation of phenol with H2O2 as the oxidant. The core-shell TS-1@mesosilica composites were prepared via a uniform coating process, while the yolk-shell TS-1@mesosilica composite was prepared using a resorcinol-formaldehyde resin (RF) middle-layer as the sacrificial template. The obtained materials were characterized by X-ray diffraction (XRD), N2 sorption, Fourier transform infrared spectoscopy (FT-IR) UV-Visible spectroscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The characterization results showed that these samples possessed highly uniform yolk/core-shell structures, high surface area (560–700 m2 g−1) and hierarchical pore structures from oriented mesochannels to zeolite micropores. Importantly, owing to their unique structural properties, these composites exhibited enhanced activity, and also selectivity in the phenol hydroxylation reaction.

  16. Correlación T-S de las masas de agua en la región del domo térmico de Costa Rica (ING

    Directory of Open Access Journals (Sweden)

    C. L. Brenes

    2016-03-01

    Full Text Available Structure and water mass properties variations of Costa Rica Dome área, are studied according to T-S analytical relations. The Hydrographic stations correspond to Expeditions EASTROPIC (Feb-Ag.Set, 1967-Feb.1986 and CRUISES 075-076 of the R/V Thomas G. Thompson (Dec. 1972- Jan 1973 A review of the water mass classification reflects that the Equatorial Pacific Water Mass and Oxygen Minimum Layer correspond to the same water mass. The least Square Method is used for T-S curve polynomial fitting, in order to obtain the local T-S (T relation.

  17. T11TS inhibits Angiopoietin-1/Tie-2 signaling, EGFR activation and Raf/MEK/ERK pathway in brain endothelial cells restraining angiogenesis in glioma model.

    Science.gov (United States)

    Bhattacharya, Debanjan; Chaudhuri, Suhnrita; Singh, Manoj Kumar; Chaudhuri, Swapna

    2015-06-01

    Malignant gliomas represent one of the most aggressive and hypervascular primary brain tumors. Angiopoietin-1, the peptide growth factor activates endothelial Tie-2 receptor promoting vessel maturation and vascular stabilization steps of angiogenesis in glioma. Epidermal growth factor receptor (EGFR) and Tie-2 receptor on endothelial cells once activated transmits signals through downstream Raf/MEK/ERK pathway promoting endothelial cell proliferation and migration which are essential for angiogenesis induction. The in vivo effect of sheep erythrocyte membrane glycopeptide T11-target structure (T11TS) on angiopoietin-1/Tie-2 axis, EGFR signaling and Raf/MEK/ERK pathway in glioma associated endothelial cells has not been investigated previously. The present study performed with rodent glioma model aims to investigate the effect of T11TS treatment on angiopoietin-1/Tie-2 signaling, EGFR activity and Raf/MEK/ERK pathway in glioma associated endothelial cells within glioma milieu. T11TS administration in rodent glioma model inhibited angiopoietin-1 expression and attenuated Tie-2 expression and activation in glioma associated brain endothelial cells. T11TS treatment also downregulated total and phosphorylated EGFR expression in glioma associated endothelial cells. Additionally T11TS treatment inhibited Raf-1 expression, MEK-1 and ERK-1/2 expression and phosphorylation in glioma associated brain endothelial cells. Thus T11TS therapy remarkably inhibits endothelial angiopoietin-1/Tie-2 signaling associated with vessel maturation and simultaneously antagonizes endothelial cell proliferation signaling by blocking EGFR activation and components of Raf/MEK/ERK pathway. Collectively, the findings demonstrate a multi-targeted anti-angiogenic activity of T11TS which augments the potential for clinical translation of T11TS as an effective angiogenesis inhibitor for glioma treatment.

  18. TS3000控制系统在贮运厂火炬气回收中的应用%Application of TS3000 Control System in the Recovery of Flare Gas in the Material Storage and Handling Factory

    Institute of Scientific and Technical Information of China (English)

    魏先锋

    2008-01-01

    介绍了TS3000三重化冗余容错集成控制系统在火炬气回收装置压缩机机组综合控制系统的集成应用.该系统TRICON客错控制器是基于三重模件冗余(TMR)结构的现代化容错控制器,能确保火炬气回收装置安全、连续、稳定运行.

  19. ZT-100与TS100型铁水车的分析比较%Analysis and Comparison the Merits and Drawbacks of ZT-100 and TS100 Hot-Metal Car

    Institute of Scientific and Technical Information of China (English)

    黄权

    2008-01-01

    随着钢铁企业的快速发展,100 t铁水车已成为铁水运输的主要设备.100 t铁水车目前有ZT-100与TS100两种,通过分析比较两种车型的优、缺点,为企业的车辆选型提供参考,同时也为加强铁水车的使用、维护、检修工作,保证车辆安全可靠运行提供帮助.

  20. The BIAS-Treatment Scale (BIAS-TS): a measure of the subjective experience of active and passive harm and facilitation.

    Science.gov (United States)

    Sibley, Chris G

    2011-05-01

    This article describes the Behaviors from Intergroup Affect and Stereotypes-Treatment Scale (BIAS-TS), a self-report measure of experiences of active harm, passive harm, active facilitation, and passive facilitation. The BIAS-TS was derived from the Behaviors from Intergroup Affect and Stereotypes (BIAS) Map, and provided reliable, replicable, and stable indexes of different harmful and facilitatory behaviors that people encounter in their day-to-day lives from multiple sources (Studies 1 and 2). The BIAS-TS subscales were uniquely associated with concurrent subjective well-being, and were distinct from the HEXACO dimensions of personality, Social Dominance Orientation, and Right-Wing Authoritarianism (Study 3). The BIAS-TS also provided novel support for the subordinate-male target hypothesis proposed by social dominance theory (Study 4). The BIAS-TS instruction set can be easily reworded to assess perceived discrimination and intergroup rejection from specific or multiple general sources and is applicable in numerous contexts. A copy of the BIAS-TS is included.

  1. Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome.

    Science.gov (United States)

    Vidal, V; García, S; Martínez, P; Corrales, A; Flórez, J; Rueda, N; Sharma, A; Martínez-Cué, C

    2012-09-18

    The Ts65Dn (TS) mouse model of Down syndrome (DS) displays a number of behavioral, neuromorphological and neurochemical phenotypes of the syndrome. Altered GABAergic transmission appears to contribute to the mechanisms responsible for the cognitive impairments in TS mice. Increased functional expression of the trisomic gene encoding an inwardly rectifying potassium channel, subfamily J, member 6 (KCNJ6) has been reported in DS and TS mice, along with the consequent impairment in GAB Aergic function. Partial display of DS phenotypes in mice harboring a single trisomy of Kcnj6 provides compelling evidence for a functional role of increased channel expression in some of the abnormal neurological phenotypes found in DS. Notably, the antiepileptic drug (AED) ethosuximide (ETH), but not other AEDs such as gabapentin (GAB), is known to inhibit KCNJ6 channels in mice. Here, we report the effect of chronic ETH and GAB on the behavioral and cognitive phenotypes of TS and disomic control (CO) mice. Neither drug significantly affected sensorimotor abilities, motor coordination or spontaneous activity in TS and CO mice. Also, ETH and GAB did not induce anxiety in the open field or plus maze tests, did not alter performance in the Morris water maze, and did not affect cued - or context - fear conditioning. Our results thus suggest that KCNJ6 may not be a promising drug target candidate in DS. As a corollary, they also show that long-term use of ETH and GAB is devoid of adverse behavioral and cognitive effects.

  2. In situ hydrothermal synthesis of a novel hierarchically porous TS-1/modified-diatomite composite for methylene blue (MB) removal by the synergistic effect of adsorption and photocatalysis.

    Science.gov (United States)

    Yuan, Weiwei; Yuan, Peng; Liu, Dong; Yu, Wenbin; Laipan, Minwang; Deng, Liangliang; Chen, Fanrong

    2016-01-15

    Hierarchically porous TS-1/modified-diatomite composites with high removal efficiency for methylene blue (MB) were prepared via a facile in situ hydrothermal route. The surface charge state of the diatomite was modified to enhance the electrostatic interactions, followed by in situ hydrothermal coating with TS-1 nanoparticles. The zeolite loading amount in the composites could be adjusted by changing the hydrothermal time. The highest specific surface area and micropore volume of the obtained composites were 521.3m(2)/g and 0.254cm(3)/g, respectively, with an optimized zeolite loading amount of 96.8%. Based on the synergistic effect of efficient adsorption and photocatalysis resulting from the newly formed hierarchically porous structure and improved dispersion of TS-1 nanoparticles onto diatomite, the composites' removal efficiency for MB reached 99.1% after 2h of photocatalytic reaction, even higher than that observed using pure TS-1 nanoparticles. Moreover, the superior MB removal kinetics of the composites were well represented by a pseudo-first-order model, with a rate constant (5.28×10(-2)min(-1)) more than twice as high as that of pure TS-1 nanoparticles (2.43×10(-2)min(-1)). The significant dye removal performance of this novel TS-1/modified-diatomite composite indicates that it is a promising candidate for use in waste water treatment.

  3. Les coûts subjectifs de l’enquête ethnographique

    Directory of Open Access Journals (Sweden)

    Bénédicte Havard Duclos

    2007-06-01

    Full Text Available L’enquête ethnographique implique toujours un engagement personnel et de longue durée du chercheur, et donc une socialisation minimale au milieu enquêté. Dans une enquête dans des associations, partis ou mouvements militants, dont un des enjeux est de produire de l’adhésion et de l’« enrôlement », la sur-socialisation au milieu enquêté est d’autant plus probable que l’affinité du chercheur avec la cause défendue est préalable au démarrage de l’enquête. À travers le récit du déroulement de l’enquête et des états psycho-moraux traversés au cours de celle-ci, sont ici donnés à voir tant les conditions rendant possibles l’adhésion et la loyauté militantes que les coûts subjectifs et éthiques liés à la rupture avec le terrain, constitutive de l’acte d’écriture.The subjective costs of the ethnographic work. Investigate as activist in the association Droit Au Logement (DAL at the end of 1990sField research always implies the personal and long-term commitment of the researcher, and thus a minimal socialization in the world investigated. In a research in activist movement, which goal is to produce commitment, these socialization can be very strong, especially when the researcher was still an activist in the starting up of the field work. Through the telling the story of progress of the research and psycho-moral states crossed during this one, are here given to see the conditions making possible the activist loyalty and the subjective and ethical costs connected to the break with the field, which is a necessity of the act of writing.Los costos subjetivos de la encuesta etnográfica. Investigar siendo militante en la asociación Droit Au Logement (DAL a fines de los años 1990.La encuesta etnográfica implica un compromiso personal de duración larga del investigador; lo que significa una socialización mínima del medio estudiado. Investigar en los medios asociativos, de partidos o de movimientos

  4. A Modernist Approach to T.S Eliot’s The Love Song of J. Alfred Prufrock

    Directory of Open Access Journals (Sweden)

    Samet Güven

    2015-12-01

    Full Text Available A Modernist Approach to T.S Eliot’s “The Love Song of J. Alfred Prufrock" Abstract  T.S. Eliot’s The Love Song of J. Alfred Prufrock carries the characteristics of modernist poetry such as objective correlative, fragmentation, free verse and irregular rhyming. It suggests a direct break with English romantic poets such as Coleridge and Wordsworth (Levis 75. Sara Thorne states that unlike the Romantic poets, Eliot attempts to convey the essence of life; and the content represents actual contemporary life rather than an escape from the grinding nature of reality (281. 'The Love Song of J. Alfred Prufrock’ exemplifies Thorne’s definition of Eliot’s poetic art clearly. The poem is about a middle-aged man who cannot make a progress in life and dare to approach women due to his timidity. Hence, the title of the poem is ironic since Prufrock never talks about his feelings of love throughout the poem. His indecisiveness is also caused by self-isolation from the society as a modern man. He finds himself in a society which is not different from a hell for him, so Eliot portrays the complexities of the modern world vividly through the inconsistent psychology of Prufrock. Elisabeth Schneider clarifies that 'The Love Song’ is more than a retreat from love, however; it is the portrait of a man in Hell, though until his truth is clearly realized, the hell appears to be merely the trivial one of the self-conscious individual in a sterile society (1104. Apart from the content, in the form Eliot uses objective correlative to relate feelings through the use of objects. The poem focuses on the dilemma caused by modern urban civilization and therefore, the purpose of this paper is to show how T.S. Eliot’s The Love Song of J. Alfred Prufrock reflects modernism in terms of its content and structure respectively.

  5. [Evaluating the performance of the UCLA method for spatially downscaling soil moisture products using three Ts/VI indices].

    Science.gov (United States)

    Ling, Zi-Wei; He, Long-Bin; Zeng, Hui

    2014-02-01

    Soil moisture products derived from microwave remote sensing data are commonly used in the studies of large-scale water resources or climate change. However, the spatial resolutions of these products are usually too coarse to be used in regional- or watershed-scale studies. Therefore, it is necessary to spatially downscale the coarse-resolution soil moisture products for use in regional- or watershed-scale studies. The UCLA method is one of the methods for spatially downscaling soil moisture products. In this method, the spatial indices (Ts/VI indices) calculated from land surface temperature and vegetation index are used as auxiliary variables for spatial downscaling. In this paper, we compared the performance of the UCLA method for spatially downscaling the coarse-resolution AMSR-E soil moisture products, using three Ts/VI indices as auxiliary variables, i. e., the soil wetness index (SW), temperature vegetation dryness index (TVDI), and vegetation temperature condition index (VTCI). These auxiliary variables were calculated from the products of MODIS land surface temperature (MYD11A1) and MODIS vegetation index (MYD13A2). The downscaled results using the three Ts/VI indices were all reasonable. However, the downscaled results using TVDI and VTCI were better than using SW. Therefore, we concluded that TVDI and VTCI are more suitable than SW to be used as the auxiliary variable when applying the UCLA method for downscaling soil moisture products. Finally, we discussed the error sources of applying the UCLA method, such as measurement errors of coarse resolution soil products, calculation errors from spatial indices, and errors from the UCLA method itself, and we also discussed the potential improvements of future research.

  6. 安驰公司通过ISO/TS 16949质量管理体系认证

    Institute of Scientific and Technical Information of China (English)

    王旭涛

    2009-01-01

    近日,山东安驰轮胎有限公司成功获得ISO/TS 16949:2002质量管理体系认证证书,这是该公司继通过国内3C认证、美国DOT认证、欧盟ECE认证、海湾GCC认证后,通过的又一个权威性质量管理体系认证。

  7. 关于ISO/TS 16949:2009中“员工激励”的思考

    Institute of Scientific and Technical Information of China (English)

    郝宗发

    2014-01-01

    汽车生产件及相关维修零件企业在实施ISO/TS 16949:2009条款6.2.2.4“员工激励”时,由于很多企业对条款理解不一,所以实施方式也各有不同.本文通过对条款的深入思考,提出一些观点以供参考.

  8. Performance of the transition radiation detector flown on the NMSU/WIZARD TS93 balloon-borne instrument

    Energy Technology Data Exchange (ETDEWEB)

    Aversa, F.; Barbiellini, G.; Boezio, M. [Trieste Univ. (Italy). Dip. di Fisica]|[INFN, Trieste (Italy); Basini, G.; Brancaccio, F.M. [INFN, Laboratori nazionali di Frascati, Frascati, Rome (Italy); Bellotti, R. [Bari Univ. (Italy). Dip. di Fisica]|[INFN, Bari (Italy); Bidoli, V. [Rome Univ. `Tor Vergata` (Italy). Dip. di Fisica]|[INFN, Sezione Univ. `Tor Vergata` Rome (Italy); Bocciolini, M. [Florence Univ. (Italy). Dip. di Fisica]|[INFN, Florence (Italy); Bronzini, F. [Rome Univ. `La Sapienza` (Italy). Dip. di Fisica]|[INFN, Sezione Univ. `La Sapienza` Rome (Italy)

    1995-09-01

    It is built and tested a transition radiation detector (TRD) to discriminate positrons from protons in the balloon flight TS 93 experiment. It is presented the TRD performance using flight data obtaining a proton-positron rejection factor of the order of 10{sup -3}. During the 24 hour flight, the data in the momentum range 4-50 GeV/c are collected. Using the TRD together with the Silicon calorimeter, it is achieved an overall rejection factor of about 10{sup -5} of positron against the proton background over the entire momentum range.

  9. poolHiTS: A Shifted Transversal Design based pooling strategy for high-throughput drug screening

    Directory of Open Access Journals (Sweden)

    Woolf Peter J

    2008-05-01

    Full Text Available Abstract Background A key goal of drug discovery is to increase the throughput of small molecule screens without sacrificing screening accuracy. High-throughput screening (HTS in drug discovery involves testing a large number of compounds in a biological assay to identify active compounds. Normally, molecules from a large compound library are tested individually to identify the activity of each molecule. Usually a small number of compounds are found to be active, however the presence of false positive and negative testing errors suggests that this one-drug one-assay screening strategy can be significantly improved. Pooling designs are testing schemes that test mixtures of compounds in each assay, thereby generating a screen of the whole compound library in fewer tests. By repeatedly testing compounds in different combinations, pooling designs also allow for error-correction. These pooled designs, for specific experiment parameters, can be simply and efficiently created using the Shifted Transversal Design (STD pooling algorithm. However, drug screening contains a number of key constraints that require specific modifications if this pooling approach is to be useful for practical screen designs. Results In this paper, we introduce a pooling strategy called poolHiTS (Pooled High-Throughput Screening which is based on the STD algorithm. In poolHiTS, we implement a limit on the number of compounds that can be mixed in a single assay. In addition, we show that the STD-based pooling strategy is limited in the error-correction that it can achieve. Due to the mixing constraint, we show that it is more efficient to split a large library into smaller blocks of compounds, which are then tested using an optimized strategy repeated for each block. We package the optimal block selection algorithm into poolHiTS. The MATLAB codes for the poolHiTS algorithm and the corresponding decoding strategy are also provided. Conclusion We have produced a practical version

  10. Optimal guaranteed cost control for an uncertain discrete T-S fuzzy system with time-delay

    Institute of Scientific and Technical Information of China (English)

    Renming WANG; Thierry Marie GUERRA; Juntao PAN

    2009-01-01

    This paper considers the guaranteed cost control problem for a class of uncertain discrete T-S fuzzy systems with time delay and a given quadratic cost function. Sufficient conditions for the existence of such controllers are derived based on the linear matrix inequalities (LMI) approach by constructing a specific nonquadratic Lyapunov-Krasovskii functional and a nonlinear PDC-like control law. A convex optimization problem is also formulated to select the optimal guaranteed cost controller that minimizes the upper bound of the closed-loop cost function. Finally, numerical examples are presented to demonstrate the effectiveness of the proposed approaches.

  11. ISO/TS 16949质量管理体系在轮胎生产中的作用%Application of ISO/TS 16949 quality management system in tire production

    Institute of Scientific and Technical Information of China (English)

    魏荣贺

    2008-01-01

    概述ISO/TS 16949质量管理体系在轮胎生产中的作用.建立ISO/TS 16949质量管理体系,可以为公司经营管理提供协同平台;满足顾客要求;采用多方论证方法是解决产品质量问题和实现部门之间良好沟通的有效途径;合理应用各种质量工具是提高质量管理水平的有效方法;预防产品缺陷,减少不合格品的产生;减少质量管理体系的重复认证;有助于轮胎企业建立自检、持续改进的管理机制;优化了人力资源管理方案,有助于轮胎企业做大做强.

  12. Altered Synaptic Marker Abundance in the Hippocampal Stratum Oriens of Ts65Dn Mice is Associated with Exuberant Expression of Versican

    Directory of Open Access Journals (Sweden)

    Matthew D Howell

    2012-01-01

    Full Text Available DS (Down syndrome, resulting from trisomy of chromosome 21, is the most common cause of genetic mental retardation; however, the molecular mechanisms underlying the cognitive deficits are poorly understood. Growing data indicate that changes in abundance or type of CSPGs (chondroitin sulfate proteoglycans in the ECM (extracellular matrix can influence synaptic structure and plasticity. The purpose of this study was to identify changes in synaptic structure in the hippocampus in a model of DS, the Ts65Dn mouse, and to determine the relationship to proteoglycan abundance and/or cleavage and cognitive disability. We measured synaptic proteins by ELISA and changes in lectican expression and processing in the hippocampus of young and old Ts65Dn mice and LMCs (littermate controls. In young (5 months old Ts65Dn hippocampal extracts, we found a significant increase in the postsynaptic protein PSD-95 (postsynaptic density 95 compared with LMCs. In aged (20 months old Ts65Dn hippocampus, this increase was localized to hippocampal stratum oriens extracts compared with LMCs. Aged Ts65Dn mice exhibited impaired hippocampal-dependent spatial learning and memory in the RAWM (radial-arm water maze and a marked increase in levels of the lectican versican V2 in stratum oriens that correlated with the number of errors made in the final RAWM block. Ts65Dn stratum oriens PNNs (perineuronal nets, an extension of the ECM enveloping mostly inhibitory interneurons, were dispersed over a larger area compared with LMC mice. Taken together, these data suggest a possible association with alterations in the ECM and inhibitory neurotransmission in the Ts65Dn hippocampus which could contribute to cognitive deficits.

  13. Altered synaptic marker abundance in the hippocampal stratum oriens of Ts65Dn mice is associated with exuberant expression of versican

    Directory of Open Access Journals (Sweden)

    Paul E Gottschall

    2012-02-01

    Full Text Available DS (Down syndrome, resulting from trisomy of chromosome 21, is the most common cause of genetic mental retardation; however, the molecular mechanisms underlying the cognitive deficits are poorly understood. Growing data indicate that changes in abundance or type of CSPGs (chondroitin sulfate proteoglycans in the ECM (extracellular matrix can influence synaptic structure and plasticity. The purpose of this study was to identify changes in synaptic structure in the hippocampus in a model of DS, the Ts65Dn mouse, and to determine the relationship to proteoglycan abundance and/or cleavage and cognitive disability. We measured synaptic proteins by ELISA and changes in lectican expression and processing in the hippocampus of young and old Ts65Dn mice and LMCs (littermate controls. In young (5 months old Ts65Dn hippocampal extracts, we found a significant increase in the postsynaptic protein PSD-95 (postsynaptic density 95 compared with LMCs. In aged (20 months old Ts65Dn hippocampus, this increase was localized to hippocampal stratum oriens extracts compared with LMCs. Aged Ts65Dn mice exhibited impaired hippocampal-dependent spatial learning and memory in the RAWM (radial-arm water maze and a marked increase in levels of the lectican versican V2 in stratum oriens that correlated with the number of errors made in the final RAWM block. Ts65Dn stratum oriens PNNs (perineuronal nets, an extension of the ECM enveloping mostly inhibitory interneurons, were dispersed over a larger area compared with LMC mice. Taken together, these data suggest a possible association with alterations in the ECM and inhibitory neurotransmission in the Ts65Dn hippocampus which could contribute to cognitive deficits.

  14. Feminized tassels of maize mop1 and ts1 mutants exhibit altered levels of miR156 and specific SBP-box genes.

    Science.gov (United States)

    Hultquist, Judd F; Dorweiler, Jane E

    2008-12-01

    Development of the unisexual maize inflorescences requires the abortion of pistillate primordia in the florets of the developing tassel and the arrest of staminate primordia in the florets of the developing ears. Mutations of many genes that lie within this sexual differentiation pathway, such as tasselseed1 (ts1), or that influence this pathway, such as mediator of paramutation 1 (mop1), result in feminization of the normally male tassel. Here, we show the loss of mop1 or ts1 function results in increased mRNA levels for several members of the SBP-box gene family. Our analyses of this family expand the number of maize SBP-box genes from 9 to 31 members. Intron-exon structures as well as phylogenetic data support the division of these family members into six groups. The SBP-box genes upregulated in feminized tassels fall into two groups, share common structural motifs and include the presence of a target site for miR156. Small RNA blots show miR156 levels are decreased in both mop1 and ts1 mutants. While there is a correlation between miR156 levels and SBP-box gene transcript levels, this correlation is not absolute, and thus we hypothesize that decreased levels of miR156 may provide competency for SBP-box gene upregulation by other common factors yet to be identified. We present a model that provides a putative link between ts1, ts2, ts4, Ts6, and mop1 in the sex-determination pathway.

  15. Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome.

    Directory of Open Access Journals (Sweden)

    Chelsee A Hewitt

    Full Text Available BACKGROUND: Down syndrome (DS individuals suffer mental retardation with further cognitive decline and early onset Alzheimer's disease. METHODOLOGY/PRINCIPAL FINDINGS: To understand how trisomy 21 causes these neurological abnormalities we investigated changes in gene expression networks combined with a systematic cell lineage analysis of adult neurogenesis using the Ts1Cje mouse model of DS. We demonstrated down regulation of a number of key genes involved in proliferation and cell cycle progression including Mcm7, Brca2, Prim1, Cenpo and Aurka in trisomic neurospheres. We found that trisomy did not affect the number of adult neural stem cells but resulted in reduced numbers of neural progenitors and neuroblasts. Analysis of differentiating adult Ts1Cje neural progenitors showed a severe reduction in numbers of neurons produced with a tendency for less elaborate neurites, whilst the numbers of astrocytes was increased. CONCLUSIONS/SIGNIFICANCE: We have shown that trisomy affects a number of elements of adult neurogenesis likely to result in a progressive pathogenesis and consequently providing the potential for the development of therapies to slow progression of, or even ameliorate the neuronal deficits suffered by DS individuals.

  16. Docetaxel/ TS-1 with radiation for unresectable squamous cell carcinoma of the esophagus--a phase II trial.

    Science.gov (United States)

    Matsumoto, Hideo; Kubota, Hisako; Higashida, Masaharu; Yoden, Eisaku; Hiratsuka, Junichi; Haruma, Ken; Nakamura, Masafumi; Hirai, Toshihiro

    2014-07-01

    We tried a new regimen of docetaxel / TS-1 (tegafur-gimestat-otastat potassium) combined with radiation for squamous cell carcinoma of the esophagus in a phase II trial. The patients, whose tumor invaded other organs without other organ metastasis, were given TS-1 (60 mg/m2/day) from days 1 to 14, and docetaxel (20-30 mg/m2) on days 1 and 8. They received radiation in 2.0 Gy from days 1 to 21. Patients were given a seven-day rest after the first course, and then were treated with the same regimen from days 28 to 49. Seventeen cases were enrolled in the study. The response rate was 76.4% (13/17). The overall 5-year survival rate was 29.6% (5/17) and median survival time was 15.2 months. Adverse events more than grade 3 occurred in 10 cases. This combination therapy may be one of the most effective treatments because of its lower rate of non-hematological adverse events and higher response rate. Three cases also underwent salvage surgery when the tumor recurred, and in one case, chemoradiation to a metastatic nodule on the thoracic wall was added. Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  17. Insecticidal effects of zinc oxide nanoparticles and Beauveria bassiana TS11 on Trialeurodes vaporariorum (Westwood, 1856 (Hemiptera: Aleyrodidae

    Directory of Open Access Journals (Sweden)

    Zahra KHOOSHE-BAST

    2016-10-01

    Full Text Available Greenhouse whitefly, Trialeurodes vaporariorum is a major pest of horticultural and ornamental plants and is usually controlled with insecticides or biological control agents. In the current study, we examined the effects of synthesized zinc oxide nanoparticles (ZnO NPs and Beauveria bassiana TS11 on T. vaporariorum adults. ZnO NPs were synthesized by precipitation method. Field emission scanning electron microscope images indicated that ZnO NPs were non-compacted uniformly. X-ray diffraction results confirmed the hexagonal wurtzite structure of ZnO NPs. Fourier transform infrared analysis showed an intense absorption peak at a range of 434-555 cm-1 related to Zn-O bond. In bioassays, adults were exposed to different concentrations of ZnO NPs (3, 5, 10, 15, 20 mg l-1 and fungi (104, 105, 106, 107, 108 spores ml-1. LC50 values for ZnO NPs and fungi were 7.35 mg l-1and 3.28×105 spores ml-1, respectively. Mortality rates obtained with ZnO NPs and fungi at the highest concentration were 91.6 % and 88.8 %, respectively. The results indicate a positive effect of ZnO NPs and B. bassiana TS11on adults. The current study was conducted under laboratory conditions, therefore, more studies are needed in field.

  18. Nucleolus-tethering system (NoTS) reveals that assembly of photobodies follows a self-organization model.

    Science.gov (United States)

    Liu, Yin; Liu, Qi; Yan, Qingqing; Shi, Leilei; Fang, Yuda

    2014-04-01

    Protein-protein interactions play essential roles in regulating many biological processes. At the cellular level, many proteins form nuclear foci known as nuclear bodies in which many components interact with each other. Photobodies are nuclear bodies containing proteins for light-signaling pathways in plants. What initiates the formation of photobodies is poorly understood. Here we develop a nucleolar marker protein nucleolin2 (Nuc2)-based method called the nucleolus-tethering system (NoTS) by artificially tethering a protein of interest to the nucleolus to analyze the initiation of photobodies. A candidate initiator is evaluated by visualizing whether a protein fused with Nuc2 forms body-like structures at the periphery of the nucleolus, and other components are recruited to the de novo-formed bodies. The interaction between two proteins can also be revealed through relocation and recruitment of interacting proteins to the nucleolus. Using the NoTS, we test the interactions among components in photobodies. In addition, we demonstrate that components of photobodies such as CONSTITUTIVELY PHOTOMORPHOGENIC 1, photoreceptors, and transcription factors tethered to the nucleolus have the capacity to form body-like structures at the periphery of the nucleolus, which contain other components of photobodies, suggesting a self-organization model for the biogenesis of photobodies.

  19. Production and properties of a raw-starch-degrading amylase from the thermophilic and alkaliphilic Bacillus sp. TS-23.

    Science.gov (United States)

    Lin, L L; Chyau, C C; Hsu, W H

    1998-08-01

    The optimum temperature and initial medium pH for amylase production by Bacillus sp. TS-23 were 55 degrees C and 8.5 respectively. Maximum amylase activity was obtained in a medium containing peptone and soluble starch as nitrogen and carbon sources. Activity staining revealed that two amylases with molecular masses of 150 and 42 kDa were produced when maltose, soluble starch or amylose was used as carbon source for growth, whereas only the 150 kDa protein was detected in the medium containing water-insoluble carbon sources. A raw-starch-degrading amylase was purified from culture supernatant of Bacillus sp. TS-23. The molecular mass of the purified amylase was estimated at 42 kDa by electrophoresis. The enzyme had a pI of 4. 2. The optimal pH and temperature for activity were 9.0 and 70 degrees C respectively. The thermoactivity of the purified enzyme was enhanced in the presence of 5 mM Ca2+; under this condition, enzyme activity could be measured at a temperature of 90 degrees C. The enzyme was strongly inhibited by Hg2+, Pb2+, Zn2+, Cu2+ and EDTA, but less affected by Ni2+ and Cd2+. The enzyme preferentially hydrolysed high-molecular-mass substrates with an alpha-1, 4-glucosidic bond except glycogen. The raw starches were partly degraded by the purified amylase to yield predominantly oligosaccharides with degrees of polymerization 3, 4 and 5.

  20. New Roman Coin Find in Estonia / Mauri Kiudsoo

    Index Scriptorium Estoniae

    Kiudsoo, Mauri, 1973-

    2013-01-01

    2012. aastal muuseumikogudesse laekunud aarete hulgast väärib esile tõstmist Kastna peitleid endisest Tõstamaa kihelkonnast. Leid sisaldas pronksist sestertse Marcus Aureliuse ja tema abikaasa Faustina noorema ajast. Tegemist on läbi aegade suurima Rooma rahadest koosneva Eesti leiuga

  1. New Roman Coin Find in Estonia / Mauri Kiudsoo

    Index Scriptorium Estoniae

    Kiudsoo, Mauri, 1973-

    2013-01-01

    2012. aastal muuseumikogudesse laekunud aarete hulgast väärib esile tõstmist Kastna peitleid endisest Tõstamaa kihelkonnast. Leid sisaldas pronksist sestertse Marcus Aureliuse ja tema abikaasa Faustina noorema ajast. Tegemist on läbi aegade suurima Rooma rahadest koosneva Eesti leiuga

  2. Influence de l’anthropisation sur la végétation locale et l’abondance des tsé-tsé au sud du Burkina Faso*

    Directory of Open Access Journals (Sweden)

    Rayaissé J.B.

    2009-03-01

    Full Text Available Des enquêtes entomologiques couplées à une analyse phytosociologique ont été menées dans la zone de Folonzo au sud du Burkina Faso sur la rivière Comoé. L’étude avait pour objectif de comparer l’abondance et la diversité des espèces de glossines dans une zone protégée et une zone non protégée, grâce à des transects perpendiculaires au cours d’eau. Des pièges ont été posés le long de ces transects depuis la rivière Comoé jusqu’à la savane en passant par la galerie forestière. Une analyse diachronique de la zone entre 1980 et 2008 a également été menée par comparaison d’images satellites Landsat et à partir de l’évolution des densités de tsé-tsé. Sur chacun des transects, une description de la flore a été faite, incluant toutes les espèces situées dans un rayon de 10 m autour de chaque piège. Il existe une très grande homogénéité floristique entre les transects, particulièrement pour la forêt-galerie, en revanche la savane montre une relative hétérogénéité. L’enquête entomologique révèle la présence de quatre espèces de glossines qui sont Glossina tachinoides (74 %, G. morsitans submorsitans (20 %, G. palpalis gambiensis (4 % et G. medicorum (2 %. Une différence nette s’observe entre la zone non protégée et la zone protégée, avec une densité moyenne de tsé-tsé quatre fois inférieure dans la première. Cette différence est particulièrement importante pour G. m. submorsitans, dont les densités sont divisées par neuf dans la zone non protégée. Cette régression s’explique par la diminution de la faune sauvage hors de la zone protégée, et ceci est extrapolable à l’ensemble du pays où cette espèce de glossine est en net recul. L’évolution du terroir de Folonzo montre une augmentation impressionnante des densités humaines et des surfaces cultivées, qui n’a pas (encore d’impact visible sur la composition floristique des lieux d’analyse, mais qui

  3. Development and immunogenicity of recombinant GapA(+) Mycoplasma gallisepticum vaccine strain ts-11 expressing infectious bronchitis virus-S1 glycoprotein and chicken interleukin-6.

    Science.gov (United States)

    Shil, Pollob K; Kanci, Anna; Browning, Glenn F; Markham, Philip F

    2011-04-12

    Mycoplasma gallisepticum (MG) is a major pathogen of poultry that causes chronic respiratory disease in chickens and infectious sinusitis in turkeys. A live attenuated vaccine, ts-11, has been used for the control of MG in several countries. The efficacy of this vaccine is highly dose dependent and the flock antibody response is weak. To improve the functionality of the vaccine and investigate its potential as a delivery vector for foreign antigens and immunomodulatory proteins, we developed a derivative of ts-11 expressing infectious bronchitis virus-S1 glycoprotein (IBV-S1) and releasing chicken interleukin-6 into the extracellular milieu (MG ts-11 C3 (+CS)) using a transposon-based delivery vector. Following administration of MG ts-11 C3 (+CS) to chickens by eye-drop, an antibody response to MG and IBV-S1, as determined by the rapid serum agglutination test (RSA) and Western blotting, respectively, could be detected. Birds inoculated with the recombinant vaccine had significantly enhanced weight gain and were partially protected against damage by pathogenic IBV. These results indicate that the ChIL-6 released by MG ts-11 C3 (+CS) may have had a non-specific effect on growth rate. They also suggest that ts-11 is a promising vaccine vector, capable of delivering heterologous protective antigens, and may also provide non-specific benefits when engineered to express immunomodulatory proteins. With some improvements in the expression system, it could be used to induce a targeted immune response against specific mucosal pathogens, and co-expression of several antigens would allow development of a novel multivalent vaccine.

  4. HPV16 infection of HaCaTs is dependent on β4 integrin, and α6 integrin processing.

    Science.gov (United States)

    Aksoy, Pınar; Abban, Cynthia Y; Kiyashka, Elizabeth; Qiang, Weitao; Meneses, Patricio I

    2014-01-20

    Our understanding of human papillomavirus (HPV) is still evolving. To further study the field, our laboratory has focused on determining the role of integrins in the initial steps of viral endocytosis into HaCaT cells. Our and others' previous findings have shown that α6 is necessary for infection. Here we show that α3 and β1 were dispensable, and we identified integrin α6β4 complex as necessary for infection in HaCaTs. β4 knock down resulted in a significant decrease in HPV16 PsV infection and perhaps most importantly resulted in defective post-translational α6 processing. We showed that the unprocessed α6 does not localize to the cell surface. We propose that the α6β4 complex is necessary for the formation of an endocytic complex that results in the signaling transduction events necessary for initial endocytosis.

  5. "edo jal̀qkina üts̀varòkaetus ma vaelda ..." : [luuletused] / Andreas Kalkun

    Index Scriptorium Estoniae

    Kalkun, Andreas, 1977-

    2002-01-01

    Sisu: "edo jal̀qkina üts̀varòkaetus ma vaelda ..." ; "tsirguq ku kiviq no satassõ taivast aràlaq ..." ; "vahtsõq silmäq pitsitä pääluu sisse ..." ; "tõppõ tõmmat haigõst ma haarõt jal̀ki ..." ; "arsatas njago sisse aigopiteh ..." ; "rühkeq yks jumalat pallõlda jaloh ..." ; "mu süä om no süüdläne täǹtäseq kuvvõ ..." ; "halvaq haavaq häitsese veiga silmih. Eluloolisi andmeid autori kohta lk. 379

  6. Study on Application of T-S Fuzzy Observer in Speed Switching Control of AUVs Driven by States

    Directory of Open Access Journals (Sweden)

    Xun Zhang

    2014-01-01

    Full Text Available Considering the inherent strongly nonlinear and coupling performance of autonomous underwater vehicles (AUVs, the speed switching control method for AUV driven by states is presented. By using T-S fuzzy observer to estimate the states of AUV, the speed control strategies in lever plane, vertical plane, and speed kept are established, respectively. Then the adaptive switching law is introduced to switch the speed control strategies designed in real time. In the simulation, acoustic Doppler current profile/side scan sonar (ADCP/SSS observation case is employed to demonstrate the effectiveness of the proposed method. The results show that the efficiency of AUV was improved, the trajectory tracking error was reduced, and the steady-state ability was enhanced.

  7. Intelligent vehicle lateral controller design based on genetic algorithm and T-S fuzzy-neural network

    Institute of Scientific and Technical Information of China (English)

    Ruan Jiuhong; Fu Mengyin; Li Yibin

    2005-01-01

    Non-linearity and parameter time-variety are inherent properties of lateral motions of a vehicle. How to effectively control intelligent vehicle (Ⅳ) lateral motions is a challenging task. Controller design can be regarded as a process of searching optimal structure from controller structure space and searching optimal parameters from parameter space.Based on this view, an intelligent vehicle lateral motions controller was designed. The controller structure was constructed by T-S fuzzy-neural network (FNN). Its parameters were searched and selected with genetic algorithm (GA). The simulation results indicate that the controller designed has strong robustness, high precision and good ride quality, and it can effectively resolve Ⅳ lateral motion non-linearity and time-variant parameters problem.

  8. 莱茵公司授予森玛仕格ISO/TS 16949证书

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    东莞森玛仕格电路有限公司是由意大利索美斯集团和英国格洛克集团共同在中国投资建立的分公司,于2007年7月打开全球合作供应链。秉承质量是企业赖以生存之本,公司已获得ISO9000—1、ISO14000—1、UL,以及刚刚获得的TUVISO/TS16949的认证,是许多跨国OEM公司首选的PCB供应商,

  9. ISO/TS 16949进入世界汽车市场的安全证书

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    ISO/TS 16949汽车行业质量管理体系是由IATF(国际汽车行业工作组)成员共开发的一个全球汽车标准。IATF由一系列汽车生产商(通用汽车、福特、戴姆勒一克莱斯勒、宝马、标致雪铁龙、大众、雷诺、菲亚特)及其各自用来向全球汽车客户提供高质量产品的贸易协会组成。

  10. A case of scirrhous gastric cancer with peritonitis carcinomatosa controlled by TS-1(R) + paclitaxel for 36 mo after diagnosis

    Institute of Scientific and Technical Information of China (English)

    Yusuke Koizumi; Hirozumi Obata; Akinori Hara; Takashi Nishimura; Kenichiro Sakamoto; Yoshihide Fujiyama

    2007-01-01

    A 34-year-old female complaining of abdominal fullness was diagnosed as scirrhous gastric cancer (type 4')with peritonitis carcinomatosa in July 2002. A combined chemotherapy regimen was selected to control massive ascites; TS-1(R) 80 mg/m2 was given orally on d 1-14,22-35, and paclitaxel 50 mg/m2 was administered intravenously on d 1, 8, 22 and 29. After 2 courses of this regimen, the primary tumor was markedly reduced,and ascites completely vanished. Alopecia (grade 1,since d 30), leukocytopenia (grade 2, on d 34) and anemia (grade 2, on d 34) were the only adverse events throughout the following courses. The chemotherapy was effective for 28 mo, and then it was discontinued upon the patient's own request, and she survived for 36mo after diagnosis.

  11. Ultrastructural features of skeletal muscle in adult and aging Ts65Dn mice, a murine model of Down syndrome.

    Science.gov (United States)

    Cisterna, Barbara; Costanzo, Manuela; Scherini, Elda; Zancanaro, Carlo; Malatesta, Manuela

    2013-10-01

    Patients with Down syndrome (DS) suffer from muscle hypotonia and an altered motor coordination whose basic mechanisms are still largely unknown. Interestingly, they show muscle weakness like healthy aged subjects, suggesting possible similarity with sarcopenia: to test this hypothesis, the Ts65Dn mouse, a suitable animal model of DS, was employed. The fine structure of skeletal fibres of the quadriceps femoris muscle was analysed in adult (12 months) and aging (19 months) animals and their age-matched euploid controls by combining morphometry and immunocytochemistry at transmission electron microscopy. Results demonstrated structural alterations of mitochondria and myonuclei reminiscent of those observed in age-related sarcopenia, supporting the hypothesis that trisomy leads to an early aging of skeletal muscle consistent with the multi-systemic premature aging typical of DS.

  12. T-S Fuzzy Model Based Control Strategy for the Networked Suspension Control System of Maglev Train

    Directory of Open Access Journals (Sweden)

    Guang He

    2015-01-01

    Full Text Available The control problem for the networked suspension control system of maglev train with random induced time delay and packet dropouts is investigated. First, Takagi-Sugeno (T-S fuzzy models are utilized to represent the discrete-time nonlinear networked suspension control system, and the parameters uncertainties of the nonlinear model have also been taken into account. The controllers take the form of parallel distributed compensation. Then, a sufficient condition for the stability of the networked suspension control system is derived. Based on the criteria, the state feedback fuzzy controllers are obtained, and the controller gains can be computed by using MATLAB LMI Toolbox directly. Finally, both the numerical simulations and physical experiments on the full-scale single bogie of CMS-04 maglev train have been accomplished to demonstrate the effectiveness of this proposed method.

  13. "edo jal̀qkina üts̀varòkaetus ma vaelda ..." : [luuletused] / Andreas Kalkun

    Index Scriptorium Estoniae

    Kalkun, Andreas, 1977-

    2002-01-01

    Sisu: "edo jal̀qkina üts̀varòkaetus ma vaelda ..." ; "tsirguq ku kiviq no satassõ taivast aràlaq ..." ; "vahtsõq silmäq pitsitä pääluu sisse ..." ; "tõppõ tõmmat haigõst ma haarõt jal̀ki ..." ; "arsatas njago sisse aigopiteh ..." ; "rühkeq yks jumalat pallõlda jaloh ..." ; "mu süä om no süüdläne täǹtäseq kuvvõ ..." ; "halvaq haavaq häitsese veiga silmih. Eluloolisi andmeid autori kohta lk. 379

  14. The Lynn Maxilla Rotator Combination Appliance and Lynn Archial Face Bow.

    Science.gov (United States)

    Lynn, J M

    1989-01-01

    This combination orthopedic traction appliance offers a new dimension in treating long faced, mouth breathing patients, who generally exhibit pre-maxillary gingival excess and lip incompetency or a short upper lip. The dynamics of excessive clockwise growth can be reversed if the physical pressures placed on the craniofacial skeletal tissues are reversed. In many instances extraction therapy or orthognatic surgery may be unnecessary to achieve acceptable occlusion and facial esthetics. Dr. Ullrich Teuscher, M.D., D.M.D., of Zurich, Switzerland published an article in the American Journal of Orthodontics in 1978, which addressed a growth related traction treatment of Class II facial patterns. This appliance expands on this concept with important modifications. There are many causes of a "long face". One of the primary causes, however, is upper airway compromise. This may be a result of enlargement of the tonsils, adenoids, nasal tubinates, nasal polyps, hemangiomas, allergies, nasal septal deviations, nasal floor narrowing, etc. In our Westernized society of "non-chewing" youths (most fast or processed food we eat today is practically pre-chewed or per-digested), the orofacial musculature is lacking in functional use. This condition further enhances the lack of full facial development because the necessary forces transmitted from the masticatory musculature to the facial skeleton are lacking. Therefore, if a person has tendencies toward a narrow-face, nasal vault, etc., there is no chance that nature's inherent counterbalancing forces will have any positive effect in resolving the airway compromise by producing wide or broad dental arches, because these forces do not exist anymore as a result of no necessity to chew food. The purpose of this paper is not to study the etiology of upper respiratory compromise, but rather to suggest a possible treatment alternative which sequentially counteracts the undesirable forces placed on the craniofacial skeleton by the aforementioned pathologies or environmental conditions.

  15. ISO/TS 16949质量管理体系深化运行模式探讨

    Institute of Scientific and Technical Information of China (English)

    刘丽丽

    2015-01-01

    潍柴动力股份有限公司作为国内内燃机行业最早贯彻ISO/TS 16949:2009《质量管理体系 汽车生产和相关服务部门组织应用ISO 9001:2008标准的详细要求》汽车行业技术规范的企业,经过自己多年的贯标经验,总结了具有实际意义和可推广意义的质量管理体系工作经验.针对ISO/TS 16949,质量管理体系内部审核包括质量管理体系审核、过程审核和产品审核,潍柴动力股份有限公司量化了质量管理体系审核,创新了过程审核(生产线稽查模式),坚持执行产品Audit评审,做到了三种审核的全部量化管理控制,并在质量人才培养方面形成了自己独有的发展模式,为目前贯标多年,处在迷茫期的企业提供了一个深化质量管理体系的工作模式,也为贯标初期的很多企业提供了少走弯路的借鉴.

  16. Experimental data report for test TS-2; Reactivity initiated accident test in NSRR with pre-irradiated BWR fuel rod

    OpenAIRE

    1993-01-01

    本報告書は、1990年2月に実施した照射済BWR燃料を用いた2回目の反応度事故模擬実験であるTS-2について実験データをまとめたものである。TS-2実験に使用した試験燃料は初期濃縮度2.79%であり、敦賀1号炉で照射されたBWR7times7型燃料棒を短尺化したものである。短尺化に供した実用燃料のバンドル平均燃焼度は21.3Gwd/tであった。NSRRにおける照射実験は、大気圧、室温の静止水冷却条件下で行い、発熱量は72pm5cal/g・fuel(ピークエンタルピ66pm5cal/g・fuel)を与えた。その結果燃料破損は生じなかった。実験条件、実験方法、パルス照射時の燃料の過渡挙動及び照射後検査の結果をまとめて示した。...

  17. Experimental data report for test TS-1; Reactivity initiated accident test in NSRR with pre-irradiated BWR fuel rod

    OpenAIRE

    1992-01-01

    本報告書は、1989年10月に実施した照射済BWR燃料を用いた最初の反応度事故模擬実験であるTS-1について、実験データをまとめたものである。TS-1実験に使用した試験燃料は、初期濃縮度2.79%であり、敦賀1号炉で照射されたBWR7times7型燃料棒を短尺化したものである。短尺化に供した実用燃料のバンドル平均燃焼度は21.3GWd/tであった。NSRRにおける照射実験は、新たに開発した専用の2重カプセルを用い、大気圧・室温の静止水冷却条件下で行い、発熱量61cal/g・fuel(ピークエンタルピ55cal/g・fuel)を与えた。その結果、燃料破損は生じなかった。実験条件、実験方法、燃料燃焼度の測定結果、パルス照射時の燃料の過渡挙動及び照射後検査の結果をまとめて示した。...

  18. Synthesis and morphology research of framework Ti-rich TS-1 containing no extraframework Ti species in the presence of CO2

    KAUST Repository

    Zhu, Guowei

    2014-02-01

    A new method to synthesis TS-1 has been developed using the carbon dioxide (CO2) as an alkalinity regulator that resulted in the increased framework Ti contents. The prepared catalyst had a Si/Ti ratio as low as 40 in contrast to the ratio of 56 prepared through conventional synthesis. The twin crystals with the length of 2 μm were formed via introduction of CO 2. The catalytic activity of TS-1 is remarkably enhanced compared with the conventional synthesis. © 2013 Elsevier B.V.

  19. Phenotypic assortment in Tetrahymena thermophila: assortment kinetics of antibiotic-resistance markers, tsA, death, and the highly amplified rDNA locus.

    Science.gov (United States)

    Merriam, E V; Bruns, P J

    1988-10-01

    Phenotypic assortment in Tetrahymena thermophila results from random distribution of alleles during amitotic division of the macronucleus. The rate of assortment is dependent on input ratio and the number of assorting units. The assortment of the antibiotic resistance markers Chx, Mpr and gal was determined and is consistent for each with the model of 45 assorting chromosomes. The gene tsA (previously ts-1) shows normal assortment, in contrast to previous reports. A mutation in the highly amplified ribosomal locus (rdnA2) assorts as if present at only 45 copies. Death of clones occurred at a rate consistent with assortment for a single gene.

  20. CMC-PVA/CS-PVA Bipolar Membrane Modified by PVA-SA-CuTsPc Nanofiber Using Electrospinning Technique%静电纺丝法制备PVA-SA-CuTsPc纳米纤维改性CMC-PVA/CS-PVA双极膜

    Institute of Scientific and Technical Information of China (English)

    周挺进; 陈晓; 陈日耀; 郑曦; 陈震

    2013-01-01

    分别用Fe3+离子和戊二醛作为交联剂对羧甲基纤维素钠(CMC)-聚乙烯醇(PVA)阳膜层和壳聚糖(CS)-聚乙烯醇阴膜层进行改性,利用静电纺丝法制备聚乙烯醇(PVA)-海藻酸钠(SA)-四磺酸基铜酞菁(CuTsPc)纳米纤维纺丝,引入中间界面层,制备CMC-PVA/PVA-SA-CuTsPc/CS-PVA双极膜(BPM),并用扫描电镜、接触角测定仪,电流密度-槽电压关系曲线、交流阻抗谱等对制备的双极膜进行了表征.研究结果表明,经PVA.SA-CuTsPc纳米纤维纺丝改性后,CMC-PVA阳膜表面亲水性增强,双极膜的中间界面层水解离效率提高,膜阻抗和槽电压下降.当电流密度为90 mA/cm2时,CMC-PVA/PVA-SA-CuTsPc/CS-PVA(w (CuTsPc)=3.0%)双极膜的电阻压降(即膜IR降)仅为0.5V.%In this paper, the carboxymethyl cellulose (CMC)-polyvinyl alcohol (PVA) cation exchange membranes and the chitosan (CS)-polyvinyl alcohol anion exchange membranes were modified by Fe 3+ and glutaraldehyde as linking reagents, respectively, and the polyvinyl alcohol-sodium alginate (SA)-copper phthalocyanine tetrasulfonic acid (CuTsPc) nanofibers prepared by electrospinning technique were introduced into the interlayer to prepare the CMC-PVA/PVA-SA-CuTsPc/CS-PVA bipolar membrane (BPM). The BPM was characterized using SEM, contact angle measurement, current-voltage characteristics, AC impedance spectroscopy and so on. The results show that after the modification with PVA-SA-CuTsPc nanofibers, the hydrophilicity of CMC-PVA membrane surface and the water splitting efficiency at the interlayer increase, and the membrane impedance and cell voltage of the BPM decrease. The trans-membrane voltage drop (IR drop) of the CMC-PVA/PVA-SA-CuTsPc/CS-PVA (w(CuTsPc) = 3.0%) BPM is as low as 0. 5V at a current density of 90 mA/cm2.

  1. Implications of TS/TOC for sedimentary environments of the southern Changjiang delta plain%总硫总有机碳比(TS/TOC)对长江三角洲南部平原沉积环境的指示意义

    Institute of Scientific and Technical Information of China (English)

    吴绪旭; 王张华; 何中发

    2012-01-01

    The present paper investigated the total sulfur ( TS) content, total organic carbon (TOC) content, chloridion ion concentration and pH value in 12 sediment sections (2.5 m long for each) from different geomorphologic units of the southern Changjiang delta plain. The regression line slopes of TS/TOC plots were also calculated for sediments from the lacustrine plain, delta plain, and modern tidal flat. We tend to examine the major factors for sulfur distribution in the Changjiang estuary and assess the feasibility of applying TS - TOC in distinguishing sedimentary environments. The results demonstrate that average values of TS/TOC of sediment sections H2 ~ H8 from the delta plain vary from 0. 026 to 0. 044. There is a significant correlation between TS and TOC and the regression line slope being 0. 027. TS/TOC values are 0. 029 ~ 0. 032 and regression line slope is 0. 037 in sediment sections H10 ~ H12 from the lacustrine plain. TS/TOC is much higher, being 0. 130 in H9 from the modern tidal flat of the Hangzhou Bay. Regression slope is also significantly higher as being 0. 117. For H1 located at the modern tidal flat of Chongming island, the average value of TS/TOC is 0. 055 and the regression slope is 0. 054. The distribution of TS/TOC and the regression slope of TS-TOC plots indicates that it could be a useful tool to distinguish sedimentary environments in the Changjiang River delta. In addition, the values of TS/TOC and regression slope of TS-TOC plots of the study area are clear lower than those of other brackish coastal deposits, reflecting the characteristics of large river mouth with huge quantity of freshwater and sediment discharge.%根据长江三角洲南部平原12个柱状样(各柱样长2.5m)沉积物中总硫(TS)、总有机碳(TOC)含量、C1-浓度及pH值,计算湖沼平原、三角洲平原和现代潮滩3个沉积地貌区TS/TOC散点回归线的斜率,并分析长江口硫元素分布的主要影响因素,检验TS/TOC在研究区识别咸水

  2. Impacts des évolutions démographiques et climatiques sur la répartition spatiale des hommes, des tsé-tsé et des trypanosomoses en Afrique de l’Ouest*

    Directory of Open Access Journals (Sweden)

    Courtin F.

    2009-03-01

    Full Text Available Les évolutions démographiques (population humaine multipliée par quatre en 50 ans, les changements climatiques et le développement économique survenus en Afrique de l’Ouest depuis maintenant un siècle ont profondément modifié le peuplement humain et les paysages dans lesquels il s’inscrit. Ces évolutions ne sont pas sans conséquences sur le complexe pathogène des trypanosomoses transmises par les glossines. En l’espace d’un siècle, la limite nord des tsé-tsé s’est déplacée vers le sud, accompagnant (mais à des échelles distinctes la descente des isohyètes et des foyers de maladie du sommeil, autrefois présents en savane et qui sont actuellement répartis en zone forestière et en zone de mangrove. On met en évidence un impact clair de la pression anthropique sur le recul des glossines du groupe morsitans, vecteurs majeurs des trypanosomoses animales. En revanche, les glossines du groupe palpalis (notamment Glossina palpalis s’adaptent aux fortes densités humaines et se maintiennent dans les plus grands centres urbains d’Afrique de l’Ouest, posant d’ailleurs la question du développement de foyers urbains dans les années à venir, comme en témoigne l’exemple récent de Kinshasa. L’étude des facteurs humains (dynamiques de peuplement et environnementaux (changements climatiques et leurs impacts dans l’espace et dans le temps, corrélée à celle des trypanosomoses et de leurs vecteurs devra permettre la mise en évidence des combinaisons spatiales capables d’expliquer la présence/absence de la maladie dans le but d’orienter les zones d’intervention médicale et anti-vectorielle. Ce type d’étude pourra être étendu à d’autres pathologies transmises par des vecteurs.

  3. PROFILING OF TS GENE EXPRESSION OF ZEBRAFISH DANIO RERIO EMBRYOGENESIS USING WHOLE MOUNT IN SITU HYBRIDIZATION%整体原位杂交法研究斑马鱼(Danio rerio)胚胎发育过程中胸苷酸合成酶(TS)的表达

    Institute of Scientific and Technical Information of China (English)

    牛荣丽; 梁丽英

    2011-01-01

    收集不同发育时期的斑马鱼胚胎,制备DIG标记的TS反义RNA探针,采用整体原位杂交方法研究胸苷酸合成酶(TS)基因在斑马鱼胚胎发育各期的时空表达状况.结果表明,在所取样的各个阶段,TS基因均有转录,但其部位不同,中囊胚过渡前后mRNA显现的部位仅存在于受精卵的动物极,10hpf时存在于整个胚胎的外围,至24hpf后集中到头部及其躯干部.112hpf在心脏部位强表达,其余部位表达相对较弱.%To analyze the expression pattern of thymidylate synthase (TS) of zebrafish Danio rerio embryogenesis, we collected zebrafish embryos at different phases and prepared TS digoxin-labeled RNA probe using whole mount in situ hybridization. We found that TS expression appeared at early zygote period, continued throughout the entire embryogenesis periods. Expression of TS was also discovered in different parts of the embryo: in the animal pole of the middle gastrula, the margin of whole embryo after 10 hours, in the head and somite after 24 hours post fertilization. After 112 hours post-fertilization, strong TS expression only in the heart. Therefore, TS plays important role in the regulation of zebrafish embryonic development.

  4. Cloning, DNA sequencing and heterologous expression of the gene for thermostable N-acylamino acid racemase from Amycolatopsis sp. TS-1-60 in Escherichia coli.

    Science.gov (United States)

    Tokuyama, S; Hatano, K

    1995-03-01

    The gene encoding the novel enzyme N-acylamino acid racemase (AAR) was cloned in recombinant phage lambda-4 from the DNA library of Amycolatopsis sp. TS-1-60, a rare actinomycete, using antiserum against the enzyme. The cloned gene was subcloned and transformed in Escherichia coli JM105 using pUC118 as a vector. The AAR gene consists of an open-reading frame of 1104 nucleotides, which specifies a 368-amino-acid protein with a molecular mass of 39411Da. The molecular mass deduced from the AAR gene is in good agreement with the subunit molecular mass (40kDa) of AAR from Amycolatopsis sp. TS-1-60. The guanosine plus cytosine content of the AAR gene was about 70%. Although the AAR gene uses the unusual initiation codon GTG, the gene was expressed in Escherichia coli using the lac promoter of pUC118. The amount of the enzyme produced by the transformant was 16 times that produced by Amycolatopsis sp. TS-1-60. When the unusual initiation codon GTG was changed to ATG, the enzyme productivity of the transformant increased to more than 37 times that of Amycolatopsis sp. TS-1-60. In the comparison of the DNA sequence and the deduced amino acid sequence of AAR with those of known racemases and epimerases in data bases, no significant sequence homology was found. However, AAR resembles mandelate racemase in that requires metal ions for enzyme activity.(ABSTRACT TRUNCATED AT 250 WORDS)

  5. One—pot Synthesis of 3,4—dihydropyrimidin—2(1H)—one Using TsOH as a Catalyst under Microwave Irradiation

    Institute of Scientific and Technical Information of China (English)

    屠树江; 房芳; 缪春宝; 蒋虹; 史达清

    2003-01-01

    A series of Biginelli compounds was synthesized using TsOH as a catalyst under microwave irradiation.This simple method provided the title compounds in 86%-98% yields by the reaction of aromatic aldehydes with 1,3-carbonyl compound and urea.The structure of 40 was determined by single crystal Xray diffraction analysis.

  6. Robust adaptive controller design for a class of uncertain nonlinear systems using online T-S fuzzy-neural modeling approach.

    Science.gov (United States)

    Chien, Yi-Hsing; Wang, Wei-Yen; Leu, Yih-Guang; Lee, Tsu-Tian

    2011-04-01

    This paper proposes a novel method of online modeling and control via the Takagi-Sugeno (T-S) fuzzy-neural model for a class of uncertain nonlinear systems with some kinds of outputs. Although studies about adaptive T-S fuzzy-neural controllers have been made on some nonaffine nonlinear systems, little is known about the more complicated uncertain nonlinear systems. Because the nonlinear functions of the systems are uncertain, traditional T-S fuzzy control methods can model and control them only with great difficulty, if at all. Instead of modeling these uncertain functions directly, we propose that a T-S fuzzy-neural model approximates a so-called virtual linearized system (VLS) of the system, which includes modeling errors and external disturbances. We also propose an online identification algorithm for the VLS and put significant emphasis on robust tracking controller design using an adaptive scheme for the uncertain systems. Moreover, the stability of the closed-loop systems is proven by using strictly positive real Lyapunov theory. The proposed overall scheme guarantees that the outputs of the closed-loop systems asymptotically track the desired output trajectories. To illustrate the effectiveness and applicability of the proposed method, simulation results are given in this paper.

  7. Evaluation of Beef by Electronic Tongue System TS-5000Z: Flavor Assessment, Recognition and Chemical Compositions According to Its Correlation with Flavor.

    Directory of Open Access Journals (Sweden)

    Xinzhuang Zhang

    Full Text Available The aim of this study was to assess the ability of electronic tongue system TS-5000Z to evaluate meat quality based on flavor assessment, recognition and correlation with the meat chemical composition. Meat was sampled from eighteen beef cattle including 6 Wagyu breed cattle, 6 Angus breed cattle and 6 Simmental breed cattle. Chemical composition including dry matter, crude protein, fat, ash, cholesterol and taurine and flavor of the meat were measured. The results showed that different breed cattle had different chemical compositions and flavor, which contains sourness, umami, saltiness, bitterness, astringency, aftertaste from astringency, aftertaste from bitterness and aftertaste from umami, respectively. A principal component analysis (PCA showed an easily visible separation between different breeds of cattle and indicated that TS-5000Z made a rapid identification of different breeds of cattle. In addition, TS-5000Z seemed to be used to predict the chemical composition according to its correlation with the flavor. In conclusion, TS-5000Z would be used as a rapid analytical tool to evaluate the beef quality both qualitatively and quantitatively, based on flavor assessment, recognition and chemical composition according to its correlation with flavor.

  8. Psychometric properties of the Portuguese version of the Acceptance and Action Questionnaire-Trauma Specific (AAQ-TS): A study with Portuguese Colonial War Veterans.

    Science.gov (United States)

    Pinto-Gouveia, José; Carvalho, Teresa; Cunha, Marina; Duarte, Joana; Walser, Robyn D

    2015-10-01

    The Acceptance and Action Questionnaire-Trauma Specific (AAQ-TS) is a self-report measure designed to assess-trauma-related psychological (in)flexibility, as conceptualized in Acceptance and Commitment Therapy. However, there are no studies to date regarding its psychometric properties. This study explores such properties in the Portuguese version of the AAQ-TS, in Portuguese Colonial War Veterans. A Principal Components Analysis (PCA) was conducted in a sample from the general population of war Veterans (N=371). Confirmatory Factor Analysis (CFA) as well as reliability and convergent validity studies were performed in a different sample from the same population (N=312). For the discriminant validity a clinical sample with a war-related PTSD (N=42) and a non-clinical sample without PTSD (N=44) were used. The CFA suggested a re-specified 15-item model with good global adjustment and factorial validity. The AAQ-TS showed internal consistency, a good temporal reliability, convergent validity with psychopathological symptoms (related to PTSD, anxiety, depression and stress) and peritraumatic dissociation (altered awareness and depersonalization/derealization). The questionnaire also discriminates between war Veterans with and without a PTSD diagnosis. The major limitation relates to the samples' characteristics and sampling methods, which can limit the generalization of results. The Portuguese version of the AAQ-TS is a reliable and valid measure to assess experiential avoidance related to trauma in Portuguese Colonial War Veterans. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. Sliding Mode Control of a Class of Uncertain Nonlinear Time-Delay Systems Using LMI and TS Recurrent Fuzzy Neural Network

    Science.gov (United States)

    Chiang, Tung-Sheng; Chiu, Chian-Song

    This paper proposes the sliding mode control using LMI techniques and adaptive recurrent fuzzy neural network (RFNN) for a class of uncertain nonlinear time-delay systems. First, a novel TS recurrent fuzzy neural network (TS-RFNN) is developed to provide more flexible and powerful compensation of system uncertainty. Then, the TS-RFNN based sliding model control is proposed for uncertain time-delay systems. In detail, sliding surface design is derived to cope with the non-Isidori-Bynes canonical form of dynamics, unknown delay time, and mismatched uncertainties. Based on the Lyapunov-Krasoviskii method, the asymptotic stability condition of the sliding motion is formulated into solving a Linear Matrix Inequality (LMI) problem which is independent on the time-varying delay. Furthermore, the input coupling uncertainty is also taken into our consideration. The overall controlled system achieves asymptotic stability even if considering poor modeling. The contributions include: i) asymptotic sliding surface is designed from solving a simple and legible delay-independent LMI; and ii) the TS-RFNN is more realizable (due to fewer fuzzy rules being used). Finally, simulation results demonstrate the validity of the proposed control scheme.

  10. Motif of misfit layer compounds (SnS) xTS 2 (T=Ti, V, Nb, Ta) in the matrix of SnS 2

    Science.gov (United States)

    Abramov, S. P.

    1999-09-01

    The possibility of T (T=Ti, V, Nb, Ta) insertion in the layer matrix of SnS 2 (when T≪Sn) presents a special case of intercalation for the specific interactions that are inherent in the misfit layer compounds (SnS) xTS 2 ( x≈1). FT Raman spectra of T xSnS 2 (T=Ti, V) with x≪1 testify to the SnS 2 matrix that is invariable with respect to a charge transfer from T to SnS 2 layers as compared with the pristine SnS 2. At the same time the T xSnS 2 structure ( x≪1) taken as a whole has substantial features in the UV-IR spectra as compared with the pristine SnS 2 but is still a semiconductor at least in the case of T=Ti. This points out in the cluster manner of TS 2 insertion in the matrix of SnS 2 with the interactions that are typical of the misfit layer compounds (SnS) xTS 2 in which metallic conductivity occurs in the TS 2 layers.

  11. Effects of the Amount of Tetrapropyl Ammonium Hydroxide in Synthesis on TS-1 Properties and Catalytic Performance in Epoxidation of Propylene

    Institute of Scientific and Technical Information of China (English)

    王亚权; 刘伟; 林永杰; 叶家鑫; 王书海; 李昊阳

    2016-01-01

    Titanium silicalite-1(TS-1)was synthesized by a hydrothermal synthesis method with different amounts of tetrapropyl ammonium hydroxide(TPAOH)as template. The as-prepared TS-1 was characterized by scanning electron microscopy, X-ray powder diffraction, Fourier-transform infrared resonance spectroscopy, ultraviolet-visible diffuse reflectance spectroscopy and nitrogen physical adsorption and desorption, and studied in the propyl-ene epoxidation with hydrogen peroxide in a fixed bed reactor. The results showed that the amount of TPAOH had a strong influence on the grain morphology, the amount of framework Ti, and the average particle sizes of TS-1. With the increase of TPAOH amount in the synthesis(the molar ratio of TPAOH/SiO2 increasing from 0.25 to 0.45), the morphology changed gradually from ellipsoids to cubes, the particle sizes of TS-1 decreased slightly, the amount of the framework Ti increased appreciably, and the catalytic stability in the propylene epoxidation increased markedly. Moreover, all the catalysts had the same selectivity to propylene epoxide. However, when the molar ratio of TPAOH/SiO2 was further increased to 0.55, the particles became large hexagons with the size distribution in a wide range, and the catalytic stability decreased sharply although the amount of the framework Ti increased further, which can be attributed to the long diffusion paths of the reactants in the zeolite.

  12. Optimization of production of the anti-keratin 8 single-chain Fv TS1-218 in Pichia pastoris using design of experiments

    Directory of Open Access Journals (Sweden)

    Sundström Birgitta E

    2011-05-01

    Full Text Available Abstract Background Optimization of conditions during recombinant protein production for improved yield is a major goal for protein scientists. Typically this is achieved by changing single crucial factor settings one at a time while other factors are kept fixed through trial-and-error experimentation. This approach may introduce larger bias and fail to identify interactions between the factors resulting in failure of finding the true optimal conditions. Results In this study we have utilized design of experiments in order to identify optimal culture conditions with the aim to improve the final yield of the anti-keratin 8 scFv TS1-218, during expression in P. pastoris in shake flasks. The effect of: pH, temperature and methanol concentration on the yield of TS1-218 using buffered minimal medium was investigated and a predictive model established. The results demonstrated that higher starting pH and lower temperatures during induction significantly increased the yield of TS1-218. Furthermore, the result demonstrated increased biomass accumulation and cell viability at lower temperatures which suggested that the higher yield of TS1-218 could be attributed to lower protease activity in the culture medium. The optimal conditions (pH 7.1, temperature 11°C and methanol concentration 1.2% suggested by the predictive model yielded 21.4 mg TS1-218 which is a 21-fold improvement compared to the yield prior to optimization. Conclusion The results demonstrated that design of experiments can be utilized for a rapid optimization of initial culture conditions and that P. pastoris is highly capable of producing and secreting functional single-chain antibody fragments at temperatures as low as 11°C.

  13. 扩展青霉TS414脂肪酶的克隆与原核表达%Cloning of Penicillium expansum TS414 lipase and its prokaryotic expression

    Institute of Scientific and Technical Information of China (English)

    朱心强; 周琼; 唐良华

    2014-01-01

    提取了扩展青霉Penicillium expansumTS414菌体的总RNA,并以反转录得到的cDNA为模板,成功扩增得到了脂肪酶基因;在此基础上,构建了重组表达载体pGEX-4T-1-PEL,并在大肠杆菌DH5α中实现了扩展青霉脂肪酶的表达;进一步采用低IPTG诱导浓度、低温、长时间的发酵策略等,使扩展青霉脂肪酶得以有活性的表达;同时,通过反复冻融细胞破碎法使其较好地从菌体细胞中分离出来,提取得到的酶液的活力达到0.49 U/mL.以上结果为后续脂肪酶分子进化等研究奠定了坚实的基础,亦可转化为高校或中学生物学实验教学的项目.

  14. Technical principles underlying limit values for release of substances for the percolation test TS3: comparison DE and NL

    Energy Technology Data Exchange (ETDEWEB)

    Van Zomeren, A.; Dijkstra, J.J. [ECN Environment and Energy Engineering, Petten (Netherlands); Susset, B. [Consulting Office SiWaP (Germany)

    2013-10-15

    Within CEN TC 351 WG 1, standardized, horizontal test methods are developed to assess the release (leaching) of dangerous substances from construction as defined in ER3 of the CPD. For granular materials TS 3, a horizontal up-flow percolation test, was further developed by CEN TC 351 WG1 and will enter the validation phase in 2013. In CEN TC 351 WG1, there are still discussions regarding the sample preparation and some test conditions. Currently, two options for sample preparation and test conditions are specified. Controversy between DE and NL regarding sample preparation and test conditions and the need for two separate options in the TS 3 percolation test are possibly for a part caused by different approaches for risk assessment in the Netherlands and in Germany and the resulting regulatory concepts. One important reason for this is, that in soil and groundwater regulations the test method and the impact assessment method are systematically linked together but the impact assessment methods and lab methods in both countries are different. The discussions in CEN TC 351 WG 1 show that there is a need to have a better mutual understanding of the relation between test method and impact assessment on the one hand and a clear overview of differences in impact assessment approaches of each country on the other hand. The aim of this project is to explain and compare the assumptions, boundary conditions and conventions of the impact assessment approach that are implemented in the upcoming German Recycling Degree and in the Soil Quality Degree of the Netherlands. Ultimately, a better understanding of the impact assessment approaches provides a basis for further discussion in WG1 to agree on only one option for the percolation test conditions. The following report is prepared by the contractors of Germany and Netherlands together to compare the two country-specific concepts. This report summarizes and explains the presentation given on the 25th of April at TC 351 WG1 in

  15. CMC-PVA/CS-PVA Bipolar Membrane Modified by PAN-CuTsPc Nanofibers Prepared Using Electrospinning Technique%静电纺丝法制备PAN-CuTsPc纳米纤维改性CMC-PVA/CS-PVA双极膜

    Institute of Scientific and Technical Information of China (English)

    喻雅萍; 周挺进; 兰瑞芳; 陈日耀; 陈震

    2014-01-01

    分别用Fe3+和戊二醛作为交联剂对羧甲基纤维素钠(CMC)-聚乙烯醇(PVA)阳膜层和壳聚糖(CS)-聚乙烯醇阴膜层进行改性,在中间界面层引入以静电纺丝技术制备的聚丙烯腈(PAN)-四磺酸基铜酞菁(CuTsPc)纳米纤维纺丝,制备了CMC-PVA/PAN-CuTsPc/CS-PVA双极膜(BPM).并用扫描电镜、接触角测定仪,电流密度-槽电压关系曲线、交流阻抗谱等对制备的双极膜进行了表征.结果表明,CMC-PVA阳膜周PAN-CuTsPc纳米纤维纺丝改性后,表面亲水性增强,中间界面层水解离效率提高,致使双极膜的膜阻抗和IR降显著降低.CMC-PVA/PAN-CuTsPc/CS-PVA(w(CuTsPc):3.0%)双极膜在90 mA·cm-2电流密度时的电阻压降(即膜IR降)仅为0.9V.

  16. Sorbitol counteracts temperature- and chemical-induced denaturation of a recombinant α-amylase from alkaliphilic Bacillus sp. TS-23.

    Science.gov (United States)

    Chi, Meng-Chun; Wu, Tai-Jung; Chen, Hsing-Ling; Lo, Huei-Fen; Lin, Long-Liu

    2012-12-01

    Enzymes are highly complex systems with a substantial degree of structural variability in their folded state. In the presence of cosolvents, fluctuations among vast numbers of folded and unfolded conformations occur via many different pathways; alternatively, certain conformations can be stabilized or destabilized. To understand the contribution of osmolytes to the stabilization of structural changes and enzymatic activity of a truncated Bacillus sp. TS-23 α-amylase (BACΔNC), we monitored amylolytic activity, circular dichroism, and fluorescence as a function of osmolytes. In the presence of trimethylamine N-oxide (TMAO) and sorbitol, BACΔNC activity was retained significantly at elevated temperatures. As compared to the control, the secondary structures of this enzyme were essentially conserved upon the addition of these two kinds of osmolytes. Fluorescence results revealed that the temperature-induced conformational change of BACΔNC was prevented by TMAO and sorbitol. However, glycerol did not provide profound protection against thermal denaturation of the enzyme. Sorbitol was further found to counteract guanidine hydrochloride- and SDS-induced denaturation of BACΔNC. Thus, some well-known naturally occurring osmolytes make a dominant contribution to the stabilization of BACΔNC.

  17. Optimized Energy Harvesting, Cluster-Head Selection and Channel Allocation for IoTs in Smart Cities

    Directory of Open Access Journals (Sweden)

    Saleem Aslam

    2016-12-01

    Full Text Available This paper highlights three critical aspects of the internet of things (IoTs, namely (1 energy efficiency, (2 energy balancing and (3 quality of service (QoS and presents three novel schemes for addressing these aspects. For energy efficiency, a novel radio frequency (RF energy-harvesting scheme is presented in which each IoT device is associated with the best possible RF source in order to maximize the overall energy that the IoT devices harvest. For energy balancing, the IoT devices in close proximity are clustered together and then an IoT device with the highest residual energy is selected as a cluster head (CH on a rotational basis. Once the CH is selected, it assigns channels to the IoT devices to report their data using a novel integer linear program (ILP-based channel allocation scheme by satisfying their desired QoS. To evaluate the presented schemes, exhaustive simulations are carried out by varying different parameters, including the number of IoT devices, the number of harvesting sources, the distance between RF sources and IoT devices and the primary user (PU activity of different channels. The simulation results demonstrate that our proposed schemes perform better than the existing ones.

  18. Optimized Energy Harvesting, Cluster-Head Selection and Channel Allocation for IoTs in Smart Cities.

    Science.gov (United States)

    Aslam, Saleem; Hasan, Najam Ul; Jang, Ju Wook; Lee, Kyung-Geun

    2016-12-02

    This paper highlights three critical aspects of the internet of things (IoTs), namely (1) energy efficiency, (2) energy balancing and (3) quality of service (QoS) and presents three novel schemes for addressing these aspects. For energy efficiency, a novel radio frequency (RF) energy-harvesting scheme is presented in which each IoT device is associated with the best possible RF source in order to maximize the overall energy that the IoT devices harvest. For energy balancing, the IoT devices in close proximity are clustered together and then an IoT device with the highest residual energy is selected as a cluster head (CH) on a rotational basis. Once the CH is selected, it assigns channels to the IoT devices to report their data using a novel integer linear program (ILP)-based channel allocation scheme by satisfying their desired QoS. To evaluate the presented schemes, exhaustive simulations are carried out by varying different parameters, including the number of IoT devices, the number of harvesting sources, the distance between RF sources and IoT devices and the primary user (PU) activity of different channels. The simulation results demonstrate that our proposed schemes perform better than the existing ones.

  19. Time-stretched real-time measurement technique for ultrafast absorption variations with TS/s sampling-rate.

    Science.gov (United States)

    Weber, Stefan; Waller, Erik H; Kaiser, Christoph; von Freymann, Georg

    2017-06-26

    We present a real-time measurement technique, based on time-stretching for measuring the temporal dynamic of ultrafast absorption variations with a sampling-rate of up to 1.1 TS/s. The single-shot captured data are stretched in a resonator-based time-stretch system with a variable stretch-factor of up to 13.8. The time-window of the time-stretch system for capturing the signal of interest is about 800 ps with an update-rate of 10 MHz. An adapted optical backpropagation algorithm is introduced for reconstructing the original unstretched event. As proof-of-principle the temporal characteristic of a picosecond semiconductor saturable absorber mirror is measured: The real-time results agree well with the results of a conventional pump-probe experiment. The time-stretch technique potentially allows to gain access to a large field of ultrafast absorption variations like semiconductor charge carrier dynamics, irreversible polymerization processes, and saturable absorber materials.

  20. Wear Characterization of Carbon Nanotubes Reinforced Acetal Spur, Helical, Bevel and Worm Gears Using a TS Universal Test Rig

    Science.gov (United States)

    Yousef, Samy; Osman, T. A.; Abdalla, Abdelrahman H.; Zohdy, Gamal A.

    2015-12-01

    Although the applications of nanotechnologies are increasing, there remains a significant barrier between nanotechnology and machine element applications. This work aims to remove this barrier by blending carbon nanotubes (CNT) with common types of acetal polymer gears (spur, helical, bevel and worm). This was done by using adhesive oil (paraffin) during injection molding to synthesize a flange and short bars containing 0.02% CNT by weight. The flanges and short bars were machined using hobbing and milling machines to produce nanocomposite polymer gears. Some defects that surfaced in previous work, such as the appearance of bubbles and unmelted pellets during the injection process, were avoided to produce an excellent dispersion of CNT in the acetal. The wear resistances of the gears were measured by using a TS universal test rig using constant parameters for all of the gears that were fabricated. The tests were run at a speed of 1420 rpm and a torque of 4 Nm. The results showed that the wear resistances of the CNT/acetal gears were increased due to the addition of CNT, especially the helical, bevel and worm gears.

  1. Real-Time Fault Detection Approach for Nonlinear Systems and its Asynchronous T-S Fuzzy Observer-Based Implementation.

    Science.gov (United States)

    Li, Linlin; Ding, Steven X; Qiu, Jianbin; Yang, Ying

    2017-02-01

    This paper is concerned with a real-time observer-based fault detection (FD) approach for a general type of nonlinear systems in the presence of external disturbances. To this end, in the first part of this paper, we deal with the definition and the design condition for an L ∞ / L 2 type of nonlinear observer-based FD systems. This analytical framework is fundamental for the development of real-time nonlinear FD systems with the aid of some well-established techniques. In the second part, we address the integrated design of the L ∞ / L 2 observer-based FD systems by applying Takagi-Sugeno (T-S) fuzzy dynamic modeling technique as the solution tool. This fuzzy observer-based FD approach is developed via piecewise Lyapunov functions, and can be applied to the case that the premise variables of the FD system is nonsynchronous with the premise variables of the fuzzy model of the plant. In the end, a case study on the laboratory setup of three-tank system is given to show the efficiency of the proposed results.

  2. Circulating Strains of Brucella abortus in Cattle in Santo Domingo De Los Tsáchilas Province - Ecuador.

    Science.gov (United States)

    Rodríguez-Hidalgo, Richar Ivan; Contreras-Zamora, Javier; Benitez Ortiz, Washington; Guerrero-Viracocha, Karina; Salcan-Guaman, Holger; Minda, Elizabeth; Ron Garrido, Lenin

    2015-01-01

    The Province of Santo Domingo de los Tsáchilas in Ecuador represents the largest informal cattle market. Because of its strategic position, cattle movement is very high and therefore we selected this region, to determine the strain variation of Brucella sp. Part of the study aimed at the isolation, biotyping, and genotyping of Brucella species from milk and supra-mammary lymph nodes of sero-positive bovines, using selective Farrell medium, biochemical assays, and IS711-PCR, AMOS-PCR, and HOOF-Prints techniques. In total, 656 animals from 12 sero-positive dairy herds and from the provincial slaughterhouse were diagnosed by Rose Bengal and Wright's Slow Agglutination test with EDTA. Amongst these animals, 50 animals were sero-positive for brucellosis. Twenty-five lymph nodes and 25 milk samples from each group of positive reactors were transferred to culture medium. Isolation was possible from 4 (16%) lymph nodes and 9 (36%) milk samples; out of these, 10 isolates were diagnosed as Brucella sp. All four isolates of lymphatic tissue corresponded to Brucella abortus biotype 1, confirmed as field strains by molecular analysis. Milk isolations, showed biochemically a more dispersed pattern in which B. abortus biotypes 1 and 4 were found; yet four samples gave a pattern similar to B. abortus biotype 2; however, only biotypes 1 and 4 were confirmed by molecular analysis. The concordance between biochemical and molecular diagnostic tests reached 76.9%.

  3. Robust H∞ Control for a Class of Uncertain Switched Fuzzy Time-Delay Systems Based on T-S Models

    Directory of Open Access Journals (Sweden)

    Yang Cui

    2013-01-01

    Full Text Available The problem of robust H∞ control for a class of uncertain switched fuzzy time-delay systems is discussed for system described by T-S fuzzy model with Lyapunov stable theory and linear matrix inequality approach. A sufficient condition in terms of the LMI is derived such that the stability of the closed-loop systems is guaranteed. The continuous state feedback controller is built to ensure the asymptotically stable closed-loop system for all allowable uncertainties, with the switching law designed to implement the global asymptotic stability of uncertain switched fuzzy time-delay systems. In this model, each and every subsystem of the switched systems is an uncertain fuzzy one to which the parallel distributed compensation (PDC controller of each sub fuzzy system system is proposed with its main condition given in a more solvable form of convex combinations. Such a switched control system is highly robust to varying parameters. A simulation shows the feasibility and effectiveness of the design method.

  4. Thermal Power Of The TS-300B Refrigerator in the Aspects of Statistical Research / Moc Cieplna Chłodziarki TS-300B W Aspekcie Badań Statystycznych

    Science.gov (United States)

    Nowak, Bernard; Łuczak, Rafał

    2015-09-01

    The article discusses the improvement of thermal working conditions in underground mine workings, using local refrigeration systems. It considers the efficiency of air cooling with direct action air compression refrigerator of the TS-300B type. As a result of a failure to meet the required operating conditions of the aforementioned air cooling system, frequently there are discrepancies between the predicted (and thus the expected) effects of its work and the reality. Therefore, to improve the operating efficiency of this system, in terms of effective use of the evaporator cooling capacity, quality criteria were developed, which are easy in practical application. They were obtained in the form of statistical models, describing the effect of independent variables, i.e. the parameters of the inlet air to the evaporator (temperature, humidity and volumetric flow rate), as well as the parameters of the water cooling the condenser (temperature and volumetric flow rate), on the thermal power of air cooler, treated as the dependent variable. Statistical equations describing the performance of the analyzed air cooling system were determined, based on the linear and nonlinear multiple regression. The obtained functions were modified by changing the values of the coefficients in the case of linear regression, and of the coefficients and exponents in the case of non-linear regression, with the independent variables. As a result, functions were obtained, which were more convenient in practical applications. Using classical statistics methods, the quality of fitting the regression function to the experimental data was evaluated. Also, the values of the evaporator thermal power of the refrigerator, which were obtained on the basis of the measured air parameters, were compared with the calculated ones, by using the obtained regression functions. These statistical models were built on the basis of the results of measurements in different operating conditions of the TS-300B

  5. The TS-Tree

    DEFF Research Database (Denmark)

    Assent, Ira; Krieger, Ralph; Afschari, Farzad;

    2008-01-01

    Continuous growth in sensor data and other temporal data increases the importance of retrieval and similarity search in time series data. Efficient time series query processing is crucial for interactive applications. Existing multidimensional indexes like the R-tree provide efficient querying fo...

  6. The TS-Tree

    DEFF Research Database (Denmark)

    Assent, Ira; Krieger, Ralph; Afschari, Farzad

    2008-01-01

    Continuous growth in sensor data and other temporal data increases the importance of retrieval and similarity search in time series data. Efficient time series query processing is crucial for interactive applications. Existing multidimensional indexes like the R-tree provide efficient querying fo...

  7. TS-EUROTRAIN

    DEFF Research Database (Denmark)

    Forde, Natalie J; Kanaan, Ahmad S; Widomska, Joanna

    2016-01-01

    and clinical course of GTS, investigate the neurobiological underpinnings of GTS and related disorders, translate research findings into clinical applications, and establish a pan-European infrastructure for the study of GTS. This includes the challenges of (i) assembling a large genetic database...... research findings into clinical applications, and establish Pan-European infrastructure for the study of GTS and associated disorders....

  8. Els aplecs «ts» i «dz» en valencià. Una anàlisi des de la teoria de l'optimitat

    Directory of Open Access Journals (Sweden)

    Jesús Jiménez

    2015-10-01

    Full Text Available This article intends to demonstrate that the final form of the clusters /ts/ and /dz/ in the Valencian dialect depends upon the behaviour of a series of universal principles referring to the syllabic structure. The author assumes that such restrictions are ranked on a language particular basis, according to the postulates of Optimality Theory (Prince & Smolensky 1993. Then, the outputs for the alveolar clusters will be the result of applying the constraint hierarchy to the set of possible candidates consistent with every input. The different results of the clusters /ts/ and /dz/ in Valencian, and this dialect' s divergences from other Catalan varieties are explained by the differences in the ranking of the principles which each variety presents.

  9. 汽车行业全面质量管理的有效途径--ISO/TS 16949标准诠释

    Institute of Scientific and Technical Information of China (English)

    谭承

    2005-01-01

    @@ 编者:2002年,本文作者谭承先生在英国访问了英国汽车制造商与经销商协会质量改进部的ROBIN LOCK先生.ROBIN先生长期致力于汽车行业质量管理,是一位有长期实践经验的专家,并全程参与了ISO/TS16949标准的制定.在访谈中,ROBIN先生结合汽车行业的实际对ISO/TS16949标准的核心内容作了详尽的诠释,现摘要刊载,以飨读者.

  10. 赛普拉斯公司通过ISO/TS 16949国际汽车标准认证

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    赛普拉斯半导体会司(Cypress Semiconductor)宣布已通过面向汽车工业的国际标难化组织/技术规范ISO/TS 16949认证.赛普拉斯公司质量部执行副总裁Sabbas Daniel说:“ISO/TS 16949认证的通过证明了我们对Cypress的零缺陷质量原则的秉承.并且使我们‘建立与客户要求直接挂钧的持久商业程序’的理念得到了增强。

  11. 汽车行业全面质量管理的有效途径——ISO/TS 16949标准诠释

    Institute of Scientific and Technical Information of China (English)

    谭承

    2005-01-01

    2002年,本文作者谭承先生在英国访问了英国汽车制造商与经销商协会质量改进部的ROBINLOCK先生。ROBIN先生长期致力于汽车行业质量管理,是一位有长期实践经验的专家,并全程参与了ISO/TS16949标准的制定。在访谈中。ROBIN先生结合汽车行业的实际对ISO/TS16949标准的核心内容作了详尽的诠释。现摘要刊载。以飨读者。

  12. H∞ Filtering for Discrete Markov Jump Singular Systems with Mode-Dependent Time Delay Based on T-S Fuzzy Model

    Directory of Open Access Journals (Sweden)

    Cheng Gong

    2014-01-01

    Full Text Available This paper investigates the H∞ filtering problem of discrete singular Markov jump systems (SMJSs with mode-dependent time delay based on T-S fuzzy model. First, by Lyapunov-Krasovskii functional approach, a delay-dependent sufficient condition on H∞-disturbance attenuation is presented, in which both stability and prescribed H∞ performance are required to be achieved for the filtering-error systems. Then, based on the condition, the delay-dependent H∞ filter design scheme for SMJSs with mode-dependent time delay based on T-S fuzzy model is developed in term of linear matrix inequality (LMI. Finally, an example is given to illustrate the effectiveness of the result.

  13. Radical Resection of a Primarily Unresectable Pancreatic Cancer After Neoadjuvant Chemotherapy Using Gemcitabine, TS-1, and Nafamostat Mesilate; Report of a Case

    Science.gov (United States)

    Fujiwara, Yuki; Shiba, Hiroaki; Uwagawa, Tadashi; Futagawa, Yasuro; Misawa, Takeyuki; Yanaga, Katsuhiko

    2015-01-01

    A 58-year-old male visited his primary physician for epigastric and back pain. Abdominal-enhanced computed tomography (CT) revealed a hypovascular pancreatic tumor measuring 17 × 11 mm in the uncinate process of the pancreas extending into the superior mesenteric plexus for greater than 180°. With a diagnosis of unresectable pancreatic cancer, the patient received gemcitabine and TS-1 with arterial infusion of nafamostat mesilate. After 3 courses of chemotherapy, enhanced CT revealed a decrease in size of the pancreatic tumor with no lymph node and distant metastasis and improved invasion of the superior mesenteric plexus down to 120°. The patient underwent R0 pancreaticoduodenectomy. The patient made a satisfactory recovery without complications and was discharged on postoperative day 10. We herein report the first curative resected case of a primarily unresectable pancreatic cancer after neoadjuvant chemotherapy using gemcitabine, TS-1, and nafamostat mesilate. PMID:25692432

  14. Use of neural network techniques to identify cosmic ray electrons and positrons during the 1993 balloon flight of the NMSU/Wizard-TS93 instrument

    Energy Technology Data Exchange (ETDEWEB)

    Bellotti, R.; Castellano, M. [Bari Univ. (Italy)]|[INFN, Bari (Italy); Candusso, M.; Casolino, M.; Morselli, A.; Picozza, P. [Rome Univ. `Tor Vergata` (Italy)]|[INFN, Rome (Italy); Aversa, F.; Boezio, M. [Trieste Univ. (Italy)]|[INFN, Trieste (Italy); Barbiellini, G. [Trieste Univ. (Italy)]|[INFN, Trieste (Italy); Basini, G. [INFN, Laboratori Nazionali di Frascati, Rome (Italy)

    1995-09-01

    The detectors used in the TS93 balloon flight produced a large volume of information for each cosmic ray trigger. Some of the data was visual in nature, other portions contained energy deposition and timing information. The data sets are amenable to conventional analysis techniques but there is no assurance that conventional techniques make full use of subtle correlations and relations amongst the detector responses. With the advent of neural network technologies, particularly adept at classification of complex phenomena, it would seem appropriate to explore the utility of neural network techniques to classify particles observed with the instruments. In this paper neural network based methodology for signal/background discrimination in a cosmic ray space experiment is discussed. Results are presented for electron and positron classification in the TS93 flight data set and will be compared to conventional analyses.

  15. Passivity Control for Uncertain T-S Fuzzy Descriptor Systems%不确定T-S模糊广义系统的无源控制

    Institute of Scientific and Technical Information of China (English)

    朱宝彦; 张庆灵; 佟绍成

    2006-01-01

    By means of matrix decomposition method a criterion is presented for the admissibility of T-S fuzzy descriptor system. Then, the problem of passivity control is studied for a kind of T-S fuzzy descriptor system with uncertain parameters, and sufficient conditions which make the closedloop system admissible and strictly passive are obtained based on linear matrix inequality (LMI).The nonstrict LMIs restricted conditions which characterize the descriptor system are transformed nnto strict ones, so testing admissibility and passivity of the system can be finished simultaneously.The design scheme of state feedback controller is also obtained. Finally, a numerical example is given to show the validity and feasibility of the proposed approach.

  16. Dimensionnement d'entrepôts d'une chaîne logistique durable pilotée par la politique Echelon Base Stock

    OpenAIRE

    Ramirez Restrepo, Laura Maria; Aguezzoul, Aicha; Hennequin, Sophie

    2015-01-01

    National audience; Nous considérons une chaîne logistique durable avec prise en compte explicite des délais de transfert entre les différents éléments de la chaîne. Le flux des matières dans le système est représenté par un modèle à flux continus et la politique de pilotage est une politique Echelon Base Stock. L'objectif de ce travail est de dimensionner les stocks des entrepôts en minimisant le coût total moyen, composé des coûts économiques (stockage, transport), auxquels sont ajoutés des ...

  17. Adaptive fuzzy neural network control design via a T-S fuzzy model for a robot manipulator including actuator dynamics.

    Science.gov (United States)

    Wai, Rong-Jong; Yang, Zhi-Wei

    2008-10-01

    This paper focuses on the development of adaptive fuzzy neural network control (AFNNC), including indirect and direct frameworks for an n-link robot manipulator, to achieve high-precision position tracking. In general, it is difficult to adopt a model-based design to achieve this control objective due to the uncertainties in practical applications, such as friction forces, external disturbances, and parameter variations. In order to cope with this problem, an indirect AFNNC (IAFNNC) scheme and a direct AFNNC (DAFNNC) strategy are investigated without the requirement of prior system information. In these model-free control topologies, a continuous-time Takagi-Sugeno (T-S) dynamic fuzzy model with online learning ability is constructed to represent the system dynamics of an n-link robot manipulator. In the IAFNNC, an FNN estimator is designed to tune the nonlinear dynamic function vector in fuzzy local models, and then, the estimative vector is used to indirectly develop a stable IAFNNC law. In the DAFNNC, an FNN controller is directly designed to imitate a predetermined model-based stabilizing control law, and then, the stable control performance can be achieved by only using joint position information. All the IAFNNC and DAFNNC laws and the corresponding adaptive tuning algorithms for FNN weights are established in the sense of Lyapunov stability analyses to ensure the stable control performance. Numerical simulations and experimental results of a two-link robot manipulator actuated by dc servomotors are given to verify the effectiveness and robustness of the proposed methodologies. In addition, the superiority of the proposed control schemes is indicated in comparison with proportional-differential control, fuzzy-model-based control, T-S-type FNN control, and robust neural fuzzy network control systems.

  18. Circulating strains of Brucella abortus in cattle in the province of Santo Domingo de los Tsáchilas - Ecuador.

    Directory of Open Access Journals (Sweden)

    Richar Ivan Rodríguez Hidalgo

    2015-03-01

    Full Text Available In Ecuador, the Province of Santo Domingo de los Tsáchilas represents the largest informal market of livestock due to its strategic position in the country; thus, given the high mobility of cattle in this region, the aim of this study was to determine the strain variation of Brucella sp.. Part of the study was the isolation, biotyping and genotyping of Brucella species isolated from milk and supra-mammary lymph nodes of sero-positive bovines. Protocols used for isolation, biotyping and genotyping of Brucella species were selective Farrell medium, biochemical assays and IS711-PCR, AMOS-PCR and HOOF-Prints techniques, respectively. In total, 656 animals from sero-positive dairy herds and from the slaughterhouse of the province were diagnosed by Rose Bengal and Wright’s Slow Agglutination test with EDTA. From these animals, 50 animals were found sero-positive for brucellosis. Twenty-five lymph nodes and 25 milk samples from each group of positive reactors were cultured and growth. Isolation was possible in 4 (16% and 9 (36%, respectively; and of these, 10 isolates were diagnosed as Brucella sp. All 4 isolates of lymphatic tissue corresponded to Brucella abortus biotype 1, confirmed as field strains by molecular analysis. Milk isolations, biochemically showed a more dispersed pattern in which B. abortus biotypes 1 and 4 were found; yet four samples gave a pattern similar to B. abortus biotype 2; however, only biotypes 1 and 4 were confirmed by molecular analysis. The concordance between biochemical and molecular diagnostic tests reached 76.9%.

  19. Photoelectron spectra of the late rare-earth misfit layer compounds (LnS)(1+x)TS2 (Ln=Tb, Dy, Ho; T=Nb, Ta)

    NARCIS (Netherlands)

    Fang, CM; Wiegers, GA; Haas, C

    1997-01-01

    Photoemission spectra (XPS and UPS) are presented for the valence band of misfit layer compounds (LnS)(1+x)TS2 with Ln = Dy, Ho or Tb; T = Nb or Ta. The Nb 4d(x)2 (or Ta 5d(x)2) conduction band is almost filled, which indicates a charge transfer of slightly less than one electron per T from the LnS

  20. Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndrome.

    Directory of Open Access Journals (Sweden)

    Matilda A Haas

    Full Text Available Down Syndrome (DS is a highly prevalent developmental disorder, affecting 1/700 births. Intellectual disability, which affects learning and memory, is present in all cases and is reflected by below average IQ. We sought to determine whether defective morphology and connectivity in neurons of the cerebral cortex may underlie the cognitive deficits that have been described in two mouse models of DS, the Tc1 and Ts1Rhr mouse lines. We utilised in utero electroporation to label a cohort of future upper layer projection neurons in the cerebral cortex of developing mouse embryos with GFP, and then examined neuronal positioning and morphology in early adulthood, which revealed no alterations in cortical layer position or morphology in either Tc1 or Ts1Rhr mouse cortex. The number of dendrites, as well as dendrite length and branching was normal in both DS models, compared with wildtype controls. The sites of projection neuron synaptic inputs, dendritic spines, were analysed in Tc1 and Ts1Rhr cortex at three weeks and three months after birth, and significant changes in spine morphology were observed in both mouse lines. Ts1Rhr mice had significantly fewer thin spines at three weeks of age. At three months of age Tc1 mice had significantly fewer mushroom spines--the morphology associated with established synaptic inputs and learning and memory. The decrease in mushroom spines was accompanied by a significant increase in the number of stubby spines. This data suggests that dendritic spine abnormalities may be a more important contributor to cognitive deficits in DS models, rather than overall neuronal architecture defects.

  1. Gene Electrotransfer of Plasmid with Tissue Specific Promoter Encoding shRNA against Endoglin Exerts Antitumor Efficacy against Murine TS/A Tumors by Vascular Targeted Effects.

    Directory of Open Access Journals (Sweden)

    Monika Stimac

    Full Text Available Vascular targeted therapies, targeting specific endothelial cell markers, are promising approaches for the treatment of cancer. One of the targets is endoglin, transforming growth factor-β (TGF-β co-receptor, which mediates proliferation, differentiation and migration of endothelial cells forming neovasculature. However, its specific, safe and long-lasting targeting remains the challenge. Therefore, in our study we evaluated the transfection efficacy, vascular targeted effects and therapeutic potential of the plasmid silencing endoglin with the tissue specific promoter, specific for endothelial cells marker endothelin-1 (ET (TS plasmid, in comparison to the plasmid with constitutive promoter (CON plasmid, in vitro and in vivo. Tissue specificity of TS plasmid was demonstrated in vitro on several cell lines, and its antiangiogenic efficacy was demonstrated by reducing tube formation of 2H11 endothelial cells. In vivo, on a murine mammary TS/A tumor model, we demonstrated good antitumor effect of gene electrotransfer (GET of either of both plasmids in treatment of smaller tumors still in avascular phase of growth, as well as on bigger tumors, already well vascularized. In support to the observations on predominantly vascular targeted effects of endoglin, histological analysis has demonstrated an increase in necrosis and a decrease in the number of blood vessels in therapeutic groups. A significant antitumor effect was observed in tumors in avascular and vascular phase of growth, possibly due to both, the antiangiogenic and the vascular disrupting effect. Furthermore, the study indicates on the potential use of TS plasmid in cancer gene therapy since the same efficacy as of CON plasmid was determined.

  2. 2-C-branched glycosides from 2'-carbonylalkyl 2-O-Ms(Ts)-C-glycosides. A tandem SN2-SN2 reaction via 1,2-cyclopropanated sugars.

    Science.gov (United States)

    Shao, Huawu; Ekthawatchai, Sanchai; Wu, Shih-Hsiung; Zou, Wei

    2004-09-30

    [reaction: see text] Under basic conditions, 2'-aldehydo (acetonyl) 2-O-Ms(Ts)-alpha-C-glycosides undergo an intramolecular S(N)2 reaction to form 1,2-cyclopropanated sugars, which react with nucleophiles (alcohols, thiols, and azide) at the anomeric carbon to give 2-C-branched glycosides. By way of contrast, the 1,2-cyclopropanes derived from 2'-ketones only react with thiols to give 2-C-branched thioglycosides.

  3. Gemcitabine-Based Chemogene Therapy for Pancreatic Cancer Using Ad-dCK::UMK GDEPT and TS/RR siRNA Strategies

    Directory of Open Access Journals (Sweden)

    Soukaina Réjiba

    2009-07-01

    Full Text Available Gemcitabine is a first-line agent for advanced pancreatic cancer therapy. However, its efficacy is often limited by its poor intracellular metabolism and chemoresistance. To exert its antitumor activity, gemcitabine requires to be converted to its active triphosphate form. Thus, our aim was to improve gemcitabine activation using gene-directed enzyme prodrug therapy based on gemcitabine association with the deoxycytidine kinase::uridine monophosphate kinase fusion gene (dCK::UMK and small interference RNA directed against ribonucleotide reductase (RRM2 and thymidylate synthase (TS. In vitro, cytotoxicity was assessed by 3-[4,5-dimethylthiazol-2-yl]-3,5-diphenyl tetrazolium bromide and [3H]thymidine assays. Apoptosis-related gene expression and activity were analyzed by reverse transcription-polymerase chain reaction, Western blot, and ELISA. For in vivo studies, the treatment efficacy was evaluated on subcutaneous and orthotopic pancreatic tumor models. Our data indicated that cell exposure to gemcitabine induced a down-regulation of dCK expression and up-regulation of TS and RR expression in Panc1-resistant cells when compared with BxPc3- and HA-hpc2-sensitive cells. The combination of TS/RRM2 small interference RNA with Ad-dCK::UMK induced a 40-fold decrease of gemcitabine IC50 in Panc1 cells. This strong sensitization was associated to apoptosis induction with a remarkable increase in TRAIL expression and a diminution of gemcitabine-induced nuclear factor-κB activity. In vivo, the gemcitabine-based tritherapy strongly reduced tumor volumes and significantly prolonged mice survival. Moreover, we observed an obvious increase of apoptosis and decrease of cell proliferation in tumors receiving the tritherapy regimens. Together, these findings suggest that simultaneous TS/RRM2-gene silencing and dCK::UMK gene overexpression markedly improved gemcitabine's therapeutic activity. Clearly, this combined strategy warrants further investigation.

  4. Pre- and post-natal melatonin administration partially regulates brain oxidative stress but does not improve cognitive or histological alterations in the Ts65Dn mouse model of Down syndrome.

    Science.gov (United States)

    Corrales, Andrea; Parisotto, Eduardo B; Vidal, Verónica; García-Cerro, Susana; Lantigua, Sara; Diego, Marian; Wilhem Filho, Danilo; Sanchez-Barceló, Emilio J; Martínez-Cué, Carmen; Rueda, Noemí

    2017-09-15

    Melatonin administered during adulthood induces beneficial effects on cognition and neuroprotection in the Ts65Dn (TS) mouse model of Down syndrome. Here, we investigated the effects of pre- and post-natal melatonin treatment on behavioral and cognitive abnormalities and on several neuromorphological alterations (hypocellularity, neurogenesis impairment and increased oxidative stress) that appear during the early developmental stages in TS mice. Pregnant TS females were orally treated with melatonin or vehicle from the time of conception until the weaning of the offspring, and the pups continued to receive the treatment from weaning until the age of 5 months. Melatonin administered during the pre- and post-natal periods did not improve the cognitive impairment of TS mice as measured by the Morris Water maze or fear conditioning tests. Histological alterations, such as decreased proliferation (Ki67+ cells) and hippocampal hypocellularity (DAPI+ cells), which are typical in TS mice, were not prevented by melatonin. However, melatonin partially regulated brain oxidative stress by modulating the activity of the primary antioxidant enzymes (superoxide dismutase in the cortex and catalase in the cortex and hippocampus) and slightly decreasing the levels of lipid peroxidation in the hippocampus of TS mice. These results show the inability of melatonin to prevent cognitive impairment in TS mice when it is administered at pre- and post-natal stages. Additionally, our findings suggest that to induce pro-cognitive effects in TS mice during the early stages of development, in addition to attenuating oxidative stress, therapies should aim to improve other altered processes, such as hippocampal neurogenesis and/or hypocellularity. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Building blocks for N-type molecular and polymeric electronics. Perfluoroalkyl- versus alkyl-functionalized oligothiophenes (nTs; n = 2-6). Systematic synthesis, spectroscopy, electrochemistry, and solid-state organization.

    Science.gov (United States)

    Facchetti, Antonio; Yoon, Myung-Han; Stern, Charlotte L; Hutchison, Geoffrey R; Ratner, Mark A; Marks, Tobin J

    2004-10-20

    The synthesis, comparative physicochemical properties, and solid-state structures of five oligothiophene (nT) series differing in substituent nature and attachment, regiochemistry, and oligothiophene core length (n) are described. These five series include the following 25 compounds: (i) alpha,omega-diperfluorohexyl-nTs 1 (DFH-nTs, n = 2-6), (ii) beta,beta'-diperfluorohexyl-nTs 2 (isoDFH-nTs, n = 2-6), (iii) alpha,omega-dihexyl-nTs 3 (DH-nTs, n = 2-6), (iv) beta,beta'-dihexyl-nTs 4 (isoDH-nTs, n = 2-6), and (v) unsubstituted oligothiophenes 5 (alphanTs, n = 2-6). All new compounds were characterized by elemental analysis, mass spectrometry, and multinuclear NMR spectroscopy. To probe and address quantitatively how the chemistry and regiochemistry of conjugated core substitution affects molecular and solid-state properties, the entire 1-5 series was investigated by differential scanning calorimetry, thermogravimetric analysis, and optical absorption and emission spectroscopies. Single-crystal X-ray diffraction data for several fluorocarbon-substituted oligomers are also presented and compared. The combined analysis of these data indicates that fluorocarbon-substituted nT molecules strongly interact in the condensed state, with unit cell level phase separation between the aromatic core and fluorocarbon chains. Surprisingly, despite these strong intermolecular interactions, high solid-state fluorescence efficiencies are exhibited by the fluorinated derivatives. Insight into the solution molecular geometries and conformational behavior are obtained from analysis of optical and variable-temperature NMR spectra. Finally, cyclic voltammetry data offer a reliable picture of frontier MO energies, which, in combination with DFT computations, provide key information on relationships between oligothiophene substituent effects and electronic response properties.

  6. Remote sensing monitoring the spatio-temporal changes of aridification in the Mongolian Plateau based on the general Ts-NDVI space, 1981–2012

    Indian Academy of Sciences (India)

    Xiaoming Cao; Yiming Feng; Juanle Wang

    2017-06-01

    This paper has developed a general Ts-NDVI triangle space with vegetation index time-series data from AVHRR and MODIS to monitor soil moisture in the Mongolian Plateau during 1981–2012, and studied the spatio-temporal variations of drought based on the temperature vegetation dryness index (TVDI). The results indicated that (1) the developed general Ts-NDVI space extracted from the AVHRR and MODIS remote sensing data would be an effective method to monitor regional drought, moreover, it would be more meaningful if the single time Ts-NDVI space showed an unstable condition; (2) the inverted TVDI was expected to reflect the water deficit in the study area. It was found to be in close negative agreement with precipitation and 10 cm soil moisture; (3) in the Mongolian Plateau, TVDI presented a zonal distribution with changes in land use/land cover types, vegetation cover and latitude. The soil moisture is low in bare land, construction land and grassland. During 1981–2012, drought was widely spread throughout the plateau, and aridification was obvious in the study period. Vegetation degradation, overgrazing, and climate warming could be considered as the main reasons.

  7. Longitudinal measures of cognition in the Ts65Dn mouse: Refining windows and defining modalities for therapeutic intervention in Down syndrome.

    Science.gov (United States)

    Olmos-Serrano, J Luis; Tyler, William A; Cabral, Howard J; Haydar, Tarik F

    2016-05-01

    Mouse models have provided insights into adult changes in learning and memory in Down syndrome, but an in-depth assessment of how these abnormalities develop over time has never been conducted. To address this shortcoming, we conducted a longitudinal behavioral study from birth until late adulthood in the Ts65Dn mouse model to measure the emergence and continuity of learning and memory deficits in individuals with a broad array of tests. Our results demonstrate for the first time that the pace at which neonatal and perinatal milestones are acquired is correlated with later cognitive performance as an adult. In addition, we find that life-long behavioral indexing stratifies mice within each genotype. Our expanded assessment reveals that diminished cognitive flexibility, as measured by reversal learning, is the most robust learning and memory impairment in both young and old Ts65Dn mice. Moreover, we find that reversal learning degrades with age and is therefore a useful biomarker for studying age-related decline in cognitive ability. Altogether, our results indicate that preclinical studies aiming to restore cognitive function in Ts65Dn should target both neonatal milestones and reversal learning in adulthood. Here we provide the quantitative framework for this type of approach.

  8. Delay-Dependent Finite-Time H∞ Controller Design for a Kind of Nonlinear Descriptor Systems via a T-S Fuzzy Model

    Directory of Open Access Journals (Sweden)

    Baoyan Zhu

    2015-01-01

    Full Text Available Delay-dependent finite-time H∞ controller design problems are investigated for a kind of nonlinear descriptor system via a T-S fuzzy model in this paper. The solvable conditions of finite-time H∞ controller are given to guarantee that the loop-closed system is impulse-free and finite-time bounded and holds the H∞ performance to a prescribed disturbance attenuation level γ. The method given is the ability to eliminate the impulsive behavior caused by descriptor systems in a finite-time interval, which confirms the existence and uniqueness of solutions in the interval. By constructing a nonsingular matrix, we overcome the difficulty that results in an infeasible linear matrix inequality (LMI. Using the FEASP solver and GEVP solver of the LMI toolbox, we perform simulations to validate the proposed methods for a nonlinear descriptor system via the T-S fuzzy model, which shows the application of the T-S fuzzy method in studying the finite-time control problem of a nonlinear system. Meanwhile the method was also applied to the biological economy system to eliminate impulsive behavior at the bifurcation value, stabilize the loop-closed system in a finite-time interval, and achieve a H∞ performance level.

  9. [Example of safety measures for antineoplastic agents immediately after market launch--a case of TS-1 capsule all example use result investigation that executes safety monitoring--].

    Science.gov (United States)

    Ito, Kunio

    2006-01-01

    As a measure to ensure safe use of TS-1 during the early marketing period, a drug use investigation was conducted on an all-case basis. Extra safety monitoring,rarely included in the use investigation,was also planned for patients who began therapy with this agent. Of the 4,177 subjects registered during the year beginning in March 1999, 3,882 started TS-1 therapy. Aside from 74 dropouts, 3,808 cases were evaluable for safety. The overall incidence of adverse reactions, with high frequencies of myelosuppression and gastrointestinal disorders, was 74.3%: a result similar to an incidence of 77.5% (100/129) found in the early phase II trial with gastric cancer patients. Safety monitoring made it possible to check if a given patients was eligible for proper use before treatment is begun. During TS-1 administration,collaboration was formed between physicians and medical representatives to ensure regular laboratory testing and to check the test findings. Measures were considered necessary to secure the safe use of drugs with manifest risk of serious adverse reactions, such as antineoplastic agents, during the initial period of market introduction. Our present approach proved effective as one of such measures.

  10. ISO/TS 16949在柳州汽车零部件生产企业中的应用

    Institute of Scientific and Technical Information of China (English)

    苏淑彦

    2015-01-01

    ISO/TS l6949:2009质量标准更系统、更全面地规范了对汽车生产件及相关维修零件组织的体系要求,自发布之后,已得到柳州所有汽车零部件生产企业的支持和认可。鉴于柳州市大多数企业在贯标认证过程中存在着普遍的困难以及激烈的市场竞争,文章在分析了柳州汽车行业现状和 ISO/TS l6949标准体系的发展及其基本要求的基础上,提出当前柳州市汽车零部件生产企业在实施ISO/TS l6949标准过程中的问题和解决措施。

  11. ISO/TS16949在柳州汽车零部件生产企业中的应用

    Institute of Scientific and Technical Information of China (English)

    苏淑彦

    2015-01-01

    ISO/TS16949:2009质量标准更系统、更全面地规范了对汽车生产件及相关维修零件组织的体系要求,自发布之后,已得到柳州所有汽车零部件生产企业的支持和认可。鉴于柳州市大多数企业在贯标认证过程中存在着普遍的困难以及激烈的市场竞争,文章在分析了柳州汽车行业现状和ISO/TS16949标准体系的发展及其基本要求的基础上,提出当前柳州市汽车零部件生产企业在实施ISO/TS16949标准过程中的问题和解决措施。

  12. Remote sensing monitoring the spatio-temporal changes of aridification in the Mongolian Plateau based on the general Ts-NDVI space, 1981-2012

    Science.gov (United States)

    Cao, Xiaoming; Feng, Yiming; Wang, Juanle

    2017-06-01

    This paper has developed a general Ts-NDVI triangle space with vegetation index time-series data from AVHRR and MODIS to monitor soil moisture in the Mongolian Plateau during 1981-2012, and studied the spatio-temporal variations of drought based on the temperature vegetation dryness index (TVDI). The results indicated that (1) the developed general Ts-NDVI space extracted from the AVHRR and MODIS remote sensing data would be an effective method to monitor regional drought, moreover, it would be more meaningful if the single time Ts-NDVI space showed an unstable condition; (2) the inverted TVDI was expected to reflect the water deficit in the study area. It was found to be in close negative agreement with precipitation and 10 cm soil moisture; (3) in the Mongolian Plateau, TVDI presented a zonal distribution with changes in land use/land cover types, vegetation cover and latitude. The soil moisture is low in bare land, construction land and grassland. During 1981-2012, drought was widely spread throughout the plateau, and aridification was obvious in the study period. Vegetation degradation, overgrazing, and climate warming could be considered as the main reasons.

  13. Comparison of the Protective Effects of Individual Components of Particulated trans-Sialidase (PTCTS), PTC and TS, against High Cholesterol Diet-Induced Atherosclerosis in Rabbits.

    Science.gov (United States)

    Garavelo, Shérrira M; Higuchi, Maria de Lourdes; Pereira, Jaqueline J; Reis, Marcia M; Kawakami, Joyce T; Ikegami, Renata N; Palomino, Suely A P; Wadt, Nilsa S Y; Agouni, Abdelali

    2017-01-01

    Previous studies showed the presence of Mycoplasma pneumoniae (M. pneumoniae) and membrane-shed microparticles (MPs) in vulnerable atherosclerotic plaques. H&S Science and Biotechnology developed PTCTS, composed by natural particles from medicinal plants (PTC) combined with trans-Sialidase (TS), to combat MPs and Mycoplasma pneumoniae. Our aim was to determine the effects of the different components of PTCTS in a rabbit model of atherosclerosis. Rabbits were fed with high cholesterol diet for 12 weeks and treated during the last 6 weeks with either vehicle, PTC, TS, or PTCTS. Lipid profile and quantification of MPs positive for Mycoplasma pneumoniae and oxidized LDL antigens were carried out. Aortas and organs were then histologically analyzed. PTCTS reduced circulating MPs positive for Mycoplasma pneumoniae and oxidized LDL antigens, reduced the plaque area in the abdominal aorta, and caused positive remodeling of the ascendant aorta. PTC caused positive remodeling and reduced plaque area in the abdominal aorta; however, TS had a lipid lowering effect. PTCTS components combined were more effective against atherosclerosis than individual components. Our data reinforce the infectious theory of atherosclerosis and underscore the potential role of circulating MPs. Therefore, the removal of Mycoplasma-derived MPs could be a new therapeutic approach in the treatment of atherosclerosis.

  14. 递归T-S模糊模型的神经网络%Neural Network Based on Recurrent T-S Fuzzy Model

    Institute of Scientific and Technical Information of China (English)

    宋春宁; 刘少东

    2013-01-01

    The dynamic recursive elements were added to the general T-S fuzzy neural network to propose a recurrent T-S fuzzy neural network.In the system identification,the unsupervised clustering algorithm and dynamic back-propagation algorithm were applied to the parameter training of this recurrent neural network and the approximation of the fuzzy neural network was proved.Comparing the identification results of the two fuzzy neural networks shows that the recurrent T-S fuzzy neural network can perform well in nonlinear system identification.%在常规T-S模糊神经网络的基础上加入动态递归元件,提出了递归T-S模糊模型的神经网络.在系统辨识中采用无监督聚类算法和动态反向传播算法训练该递归神经网络的参数,给出了该递归网络的逼近性证明.辨识效果与常规T-S模糊模型作比较,说明递归T-S模糊模型的神经网络在非线性系统辨识中表现出更好的性能.

  15. Les coûts du diabète sur 10 ans au Canada : intégration des coûts en soins de santé imputables au diabète à un modèle de prédiction de son incidence

    Directory of Open Access Journals (Sweden)

    Anja Bilandzic

    2017-01-01

    Full Text Available Introduction : Notre objectif était d’estimer les coûts de santé directs liés au traitement du diabète au Canada sur 10 ans, à l’aide de données de sondages nationaux et d’un outil de prévision du risque de diabète, ainsi que les coûts par personne. Méthodologie : Nous avons utilisé le Diabetes Population Risk Tool pour estimer le nombre de nouveaux cas de diabète chez les personnes âgées de 20 ans et plus sur 10 ans (jusqu'en 2022 à l’aide des données de 2011 et de 2012 de l’Enquête sur la santé dans les collectivités canadiennes. Nous avons évalué les coûts liés au diabète à partir d’une étude de cohorte faisant appel à l’appariement par score de propension, en utilisant la base de données sur le diabète de l’Ontario ainsi que d’autres données administratives. Nous avons calculé les coûts totaux en utilisant les coûts associés aux nouveaux cas, en tenant compte du sexe, de l’année du diagnostic et des taux de mortalité annuels dus à la maladie. Résultats : D'après nos calculs, le risque de développer le diabète sur 10 ans s’élevait pour la population canadienne en 2011-2012 à 9,98 %, soit 2,16 millions de nouveaux cas. Les coûts totaux en soins de santé imputables au diabète pendant cette période sont de 15,36 milliards (7,55 milliards pour les femmes et 7,81 milliards pour les hommes. Ce sont les hospitalisations de courte durée qui constituent la majeure partie de ces coûts (43,2 %. Des interventions menées au sein de la population entraînant une perte de poids de 5 % au sein de la population permettraient de réduire les coûts des soins de santé de 2,03 milliards de dollars. Une réduction du risque de 30 % obtenue grâce à des interventions auprès des personnes à plus haut risque de développer le diabète (c.-à-d. les 10 % au sommet du groupe à risque le plus élevé entraînerait des économies de l’ordrede 1,48 million de dollars. Conclusion : D'ici 2022

  16. Metode Pembacaan Turâts Arab-Islam: Perspekti Muhammad ‘Abid al-Jâbirî

    Directory of Open Access Journals (Sweden)

    Abdul Mukti Ro’uf

    2010-06-01

    Full Text Available The way how turâts (a term only found in contemporary Arabic-Islam or tradition is viewed has been a critical problem. This is because queries about it imply rise and or fall of a civilization. This thesis has at least been proved by facts of history that since the midst 19th century the world of Arabic-Islam thoughts have been moving backward compared to that in the Western-modern thoughts. This research will analyze Muhammad ‘Âbid al-Jâbirî’s thoughts that represented contemporary thinkers. Al-Jâbirî was a muslim intellectual born in Feiji Southeast-Marocco in 1936. His initial acquaintance with philosophical thoughts related to three prominent figures of Karl Marx (1818-1890, Gaston Bachelard (1884-1962, and Louis Althusser (1918-1990. He was grown up in a setting of Maghribi thoughts (Marocco-Andalusia, which was influenced by traditions of French philosophy of Marxian. However, he doubted Marxian approaches in Islamic history context.Abstrak: Cara bagaimana turâts—sebuah terma yang hanya ditemukan dalam tradisi Arab-Islam kontemporer—dipahami telah menjadi suatu problem yang amat mendesak. Hal itu karena pengabaian atasnya akan berimplikasi pada kebangkitan atau kejatuhan suatu peradaban. Tesis itu setidaknya telah dibuktikan oleh kenyataan sejarah bahwa semenjak pertengahan abad XIX pemikiran Arab-Islam mengalami kemunduran dibandingkan dengan pemikiran-pemikiran Barat moderen. Kajian ini akan menganalisis pemikiran Muhammad ‘Âbid al-Jâbirî’s yang merepresentasikan para pemikir kontemporer. Al-Jâbirî adalah seorang intelektual muslim yang terlahir di Feiji, Maroko Tenggara, pada tahun 1936.  Perkenalan awalnya dengan pemikiran filosofis berkaitan dengan tiga figur penting, yaitu Karl Marx (1818-1890, Gaston Bachelard (1884-1962, and Louis Althusser (1918-1990. Dia tumbuh besar dalam latar pemikiran-pemikiran Maghribi (Marocco-Andalusia, yang dipengaruhi oleh tradisi filsafat Perancis yang Marxian. Namun demikian

  17. Constraining |V(td)|/|V(ts)| Using Radiative Penguin B -> V(K*/rho/omega)gamma Decays

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Ping; /Wisconsin U., Madison

    2006-03-08

    Exclusive radiative penguin B decays, B {yields} (K*{sup 0}/K*{sup +}) and B {yields} ({rho}/{omega}){gamma}, are flavor-changing neutral-current (FCNC) processes. Studies of these decays are of special interest in testing Standard Model (SM) predictions and searching for other beyond-the-SM FCNC interactions. Using 89 x 10{sup 6} B{bar B} pairs from BABAR, we measure the branching fraction ({Beta}), CP-asymmetry ({Alpha}), and isospin asymmetry ({Delta}{sub 0-}) of B {yields} (K*{sup 0}/K*{sup +}){gamma} as follows: {Beta}(B{sup 0} {yields} K*{sup 0}{gamma}) = 3.92 {+-} 0.20(stat.) {+-} 0.24(syst.); {Beta}(B{sup +} {yields} K*{sup +}{gamma}) = 3.87 {+-} 0.28(stat.) {+-} 0.26(syst.); {Alpha}(B {yields} K*{gamma}) = -0.013 {+-} 0.36(stat.) {+-} 0.10(syst.); {Delta}{sub 0-}(B {yields} K*{gamma}) = 0.050 {+-} 0.045(stat.) {+-} 0.028(syst.) {+-} 0.024(R{sup +/0}). The 90% confidence intervals for the CP-asymmetry and the isospin-asymmetry in the B {yields} K*{gamma} decay are given as: -0.074 < {Alpha}(B {yields} K*{gamma}) < 0.049, -0.046 < {Delta}{sub 0-} (B {yields} K*{gamma}) < 0.146. We also search for B {yields} ({rho}/{omega}){gamma} decays using 211 x 10{sup 6} B{bar B} pairs from BABAR. No evidence for these decays is found. We set the upper limits at 90% confidence level for these decays: {Beta}(B{sup 0} {yields} {rho}{sup 0}{gamma}) < 0.4 x 10{sup -6}; {Beta}(B{sup +}{yields} {rho}{sup =}{gamma}) < 1.8 x 10{sup -6}; {Beta}(B{sup 0} {yields} {omega}{gamma}) < 1.0 x 10{sup -6}; {bar {Beta}}(B {yields} ({rho}/{omega}){gamma}) < 1.2 x 10{sup -6}. These results are in good agreement with the SM predictions. The branching fractions of these decays are then used to constrain the ratio |V{sub td}|/|V{sub ts}|.

  18. Stability of continuous phenol hydroxylation over TS-1 in submerged dual ceramic membrane reactor%浸没式双管式陶瓷膜反应器用于TS-1催化苯酚羟基化的稳定性

    Institute of Scientific and Technical Information of China (English)

    姜红; 孟烈; 陈日志; 金万勤; 邢卫红

    2012-01-01

    在浸没式双管式陶瓷膜反应器中考察TS-1分子筛上H202氧化苯酚羟基化制苯二酚连续反应的稳定性.研究发现,30 h连续反应过程中,苯二酚选择性保持不变,苯酚转化率逐渐下降.采用场发射扫描电子显微镜结合元素组分分析的测试方法分析使用后的陶瓷膜上的污染物,发现陶瓷膜上吸附少量TS -1催化剂,说明催化剂吸附是造成转化率下降的原因之一.采用X线衍射、紫外可见反射光谱、傅里叶变换红外光谱、N2吸附-脱附以及热分析等测试方法分析反应前后的TS -1催化剂性质,结果表明:经过30 h的连续反应,TS -1分子筛的结晶度、MFI骨架结构和骨架中的钛含量没有显著变化,而其比表面积和孔体积显著降低,说明连续运行过程中产生的有机副产物沉积堵塞分子筛孔道造成TS -1催化剂失活,是导致反应转化率下降的主要原因.%The operation stability of a submerged dual-membrane reactor was evaluated by the phenol hydroxylation to hydroquinone and catechol over TS-1 catalyst. In a 30 h continuous operation, the selectivity remained stable while the conversion decreased gradually. The fresh membrane and the used one were characterized by field emisson scanning electron microscopy ( FESEM) and energy dispersive X-ray spec-troscopy (EDX) analysis. Results showed that some TS-1 catalyst particles aggregated on the membrane surface was one of the reasons for the decrease of phenol conversion. The fresh and used catalysts were characterized by X-ray diffraction ( XRD ) , UV-vis, Fourier transform infrared spectroscopy ( FT-IR ) , N2 adsorption-desorption, and thermogravimetry (TG) analysis techniques. It was found that the crystallini-ty, structure of TS-1 and the content of titanium in the framework did not change obviously. Compared with the fresh catalyst,the channels of the TS-1 used catalyst were blocked by organic by products,leading to the decrease in the surface area and

  19. Identification of Taenia solium Insulin Receptor TsIR-1316 and Expression of Its Ligand Binding Domain%猪带绦虫胰岛素受体TsIR-1316的鉴定及其配体结合结构域的表达

    Institute of Scientific and Technical Information of China (English)

    魏艳玲; 郭爱疆; 张少华; 刘光学; 侯俊玲; 骆学农

    2016-01-01

    目的 分析鉴定猪带绦虫(Taenia solium)胰岛素受体TsIR-1316的结构特征,并对其配体结合结构域(LBD)进行表达. 方法 参考GeneDB数据库猪带绦虫基因组注释信息,设计特异性引物,克隆获得TsIR-1316基因,用BLASTN和BLASTP分别对其核苷酸和氨基酸序列进行同源性比对,并用在线软件对该蛋白的信号肽和结构域进行预测分析.将其LBD克隆至原核表达载体pET-30a(+),表达、纯化后进行十二烷基硫酸钠-聚丙烯酰胺凝胶电泳(SDS-PAGE)分析,用猪囊尾蚴阳性血清和TsIR-LBD免疫兔血清进行蛋白质印迹(Western blotting)鉴定. 结果 TsIR-1316的开放阅读框为5 196 bp,编码1 732个氨基酸,与多房棘球绦虫(Echinococcus multilocularis)的同源性为84%,具有典型的酪氨酸激酶家族的结构特征和“V”型三级结构.SDS-PAGE结果显示,所表达的重组蛋白相对分子质量(M)为59000,与预期一致.Western blotting检测结果显示,重组蛋白可与猪囊尾蚴阳性血清及TsIR-LBD免疫兔血清发生特异性反应,在Mr 59 000处出现特异条带. 结论 克隆并鉴定了猪带绦虫TsIR-1316基因,其LBD的表达产物可被猪囊尾蚴阳性血清所识别,具有良好的反应原性.

  20. Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome.

    Science.gov (United States)

    Giacomini, Andrea; Stagni, Fiorenza; Trazzi, Stefania; Guidi, Sandra; Emili, Marco; Brigham, Elizabeth; Ciani, Elisabetta; Bartesaghi, Renata

    2015-10-01

    Neurogenesis impairment starting from early developmental stages is a key determinant of intellectual disability in Down syndrome (DS). Previous evidence provided a causal relationship between neurogenesis impairment and malfunctioning of the mitogenic Sonic Hedgehog (Shh) pathway. In particular, excessive levels of AICD (amyloid precursor protein intracellular domain), a cleavage product of the trisomic gene APP (amyloid precursor protein) up-regulate transcription of Ptch1 (Patched1), the Shh receptor that keeps the pathway repressed. Since AICD results from APP cleavage by γ-secretase, the goal of the current study was to establish whether treatment with a γ-secretase inhibitor normalizes AICD levels and restores neurogenesis in trisomic neural precursor cells. We found that treatment with a selective γ-secretase inhibitor (ELND006; ELN) restores proliferation in neurospheres derived from the subventricular zone (SVZ) of the Ts65Dn mouse model of DS. This effect was accompanied by reduction of AICD and Ptch1 levels and was prevented by inhibition of the Shh pathway with cyclopamine. Treatment of Ts65Dn mice with ELN in the postnatal period P3-P15 restored neurogenesis in the SVZ and hippocampus, hippocampal granule cell number and synapse development, indicating a positive impact of treatment on brain development. In addition, in the hippocampus of treated Ts65Dn mice there was a reduction in the expression levels of various genes that are transcriptionally regulated by AICD, including APP, its origin substrate. Inhibitors of γ-secretase are currently envisaged as tools for the cure of Alzheimer's disease because they lower βamyloid levels. Current results provide novel evidence that γ-secretase inhibitors may represent a strategy for the rescue of neurogenesis defects in DS.

  1. Detection and functional annotation of misregulated microRNAs in the brain of the Ts65Dn mouse model of Down syndrome

    Institute of Scientific and Technical Information of China (English)

    HE Xiang-jun; XIAO Yun; ZHANG Qi; MA Li-ping; LI Na; YANG Jing

    2013-01-01

    Background Brain hypoplasia and mental retardation in Down syndrome (DS) can be attributed to a severe and selective disruption of neurogenesis.Secondary disruption of the transcriptome,as well as primary gene dosage imbalance,is responsible for the phenotype.MicroRNA (miRNA) expression is relatively abundant in brain tissue.Perturbed miRNA expression might contribute to the cellular events underlying the pathology in DS.Methods MiRNA expression profiles in the cerebrum of Ts65Dn mice,a DS model,were examined with a real-time RT-PCR array.MiRNA target gene expression was detected by real-time quantitative PCR and Western blotting.Based on the prediction of their cerebrum-specific targets,the functions of the misregulated miRNAs were annotated by Gene Ontology (GO) enrichment analysis.Results A total of 342 miRNAs were examined.Among them,20 miRNAs showed decreased expression in the brains of Ts65Dn mice,and some of these belonged to the same family.Two known targets of the miR-200 family,Lfng and Zeb2,were specifically selected to compare their expression in the cerebrum of Ts65Dn mice with those of euploids.However,no significant difference was found in terms of mRNA and protein expression levels of these genes.By enrichment analysis of the cerebrum-specific targets of each miRNA,we found that 15 of the differential miRNAs could significantly affect target genes that were enriched in the GO biological processes related to nervous system development.Conclusion Perturbed expression of multiple functionally cooperative miRNAs contributes to the cellular events underlying the pathogenesis of DS.

  2. Long-Run Diversion Effects of Changes in Truck Size and Weight (TS&W) Restrictions: An Update of the 1980 Friedlaender Spady Analysis

    OpenAIRE

    McCullough, Gerard J.

    2013-01-01

    The purpose of this analysis is to estimate the effect that revised truck size and weight (TS&W) restrictions would have on competitive rail-truck markets in the United States. The analysis is based on a classic study of the intercity freight markets that Ann Friedlaender and Richard Spady (FS) published in the Review of Economics and Statistics in 1980.1 The FS study provided a macro-level perspective on the freight markets by focusing on transportation decisions in key industrial sectors—fo...

  3. 中国重汽集团济南桥箱有限公司通过TS16949认证

    Institute of Scientific and Technical Information of China (English)

    郭化南

    2006-01-01

    10月26日,Tu V北德认证(天津)有限公司正式向中国重汽集团济南桥箱有限公司颁发IATF(国际汽车工业特别工作小组)欧洲总部TS 16949证书,这是国内重型车桥行业首家企业通过国际汽车工业质量认证,标志着中国重汽在发展重型汽车整车技术的同时,着力打造

  4. [A new regimen for TS-1 therapy designed to minimize adverse reactions by introducing a one-week interval after each two-week dosing session].

    Science.gov (United States)

    Kimura, Yutaka; Kikkawa, Nobuteru; Iijima, Shohei; Kato, Takeshi; Naoi, Yasuto; Hayashi, Taro; Tanigawa, Takahiko; Yamamoto, Hitoshi; Kurokawa, Eiji

    2002-08-01

    It has been reported that the response rate to TS-1 of advanced recurrent gastric cancer was the highest rate (46.5%) of effectiveness among anti-cancer agents, but the incidence of adverse reactions to this drug has been found to be as high as 83.2%, with grade 3 or severer reactions occurring in 20.3% of patients. Taking into consideration the post-marketing survey finding that adverse reactions to the drug first appear 2-3 weeks after the start of oral TS-1 therapy, we attempted a new dosing regimen for this drug, wherein each session of therapy lasted for 2 weeks, with a one-week interval between two consecutive sessions (herein-after called "the 2-week regimen"). This regimen was employed based on the expectation that the adverse reactions to the drug would be minimized and that the consecutive dosing period could be prolonged, while keeping the anti-cancer potency at a level similar to that expected with the 4-week dosing regimen with a 2-week interval between sessions (the 4-week regimen). The subjects were 38 patients with advanced or recurrent stomach cancer who were treated with TS-1 at our center between September 1999 and November 2001. Twenty-four patients treated using the 4-week method until January 2001 were taken as a historical control, and compared with 14 patients treated using the 2-week method from February 2001 and afterwards. The incidence of adverse reactions was 71% in the 2-week regimen group against 92% in the 4-week regimen group. The incidence of grade 3 or severe adverse reactions was 8% in the 2-week group and 21% in the 4-week group. Thus, the incidence of adverse reactions was lower in the 2-week group. The percentage of patients who complied with the dosing instructions completely during a 6-month period, as evaluated by the Kaplan-Meier method, was 86% in the 2-week group and 58% in the 4-week group. The response rate, as calculated in patients whose lesions could be evaluated, was 25% in the 2-week group and 19% in the 4-week

  5. Optimal Design of TS Fuzzy Control System Based on DNA Evolutionary Algorithm%采用DNA进化算法优化设计TS模糊控制器

    Institute of Scientific and Technical Information of China (English)

    翁妙凤

    2003-01-01

    The DNA evolutionary algorithm(DNA-EA)and the DNA genetic algorithm(DNA-GA)based on a new DNA encoding method are propsed based on the structure and the genetic mechanism of biological DNA. The DNA-EA and the DNA-GA are applied into the optimal design of TS fuzzy control system. The simulation results show the effectiveness of the two DNA algorithms, excellent self-learning capability. However, the DNA-EA is superior to the DNA-GA in the simulation performance.

  6. 基于TS模糊区域模型的航天器姿态控制%Attitude Control of Spacecraft Based on TS Fuzzy Region Model

    Institute of Scientific and Technical Information of China (English)

    白圣建; 黄新生

    2011-01-01

    To tar problem that the fuel consuming and the flexible appendage deployment induce the parameter uncertainty of the dynamic model of flexible spacecraft, the robust controller of uncertain TS fuzzy systems is designed to control the slew maneuvering of flexible spacecraft. The TS fuzzy region model is developed from the uncertain TS fuzzy model, where the fuzzy region controller is derived hy using PDC concept. The stability of the fuzzy system is analyzed via the piecewise Lyapunov approach- The dynamic equations of flexible spacecraft are described as uncertain TS fuzzy model, where the fuzzy region controller is obtained. Numerical simulations show that the rotational maneuver and vibration suppression are accomplished in spite of parameter uncertainty.%由于燃料消耗和柔性部件展开等原因,挠性航天器的姿态动力学方程存在着参数的不确定性,因此,研究参数不确定TS模糊系统的鲁棒控制器设计方法,并将其应用到平面机动挠性航天器的姿态机动控制问题.将参数不确定TS模糊系统描述为TS模糊区域模型,根据PDC原理设计了模糊区域控制器,并用分段Lyapunov法证明了模糊控制系统的全局渐近稳定性.将平面机动挠性航天器姿态动力学方程描述为参数不确定TS模糊区域模型,在此基础上设计了模糊区域控制器,进行了数值仿真分析.仿真结果表明,TS模糊区域控制器具有很强的鲁棒性,可以实现挠性航天器的高精度姿态控制和振动抑制.

  7. Robust Non-Fragile Guaranteed Cost Control for Nonlinear Time Delay Discrete-Time Systems Based on T-S Model

    Institute of Scientific and Technical Information of China (English)

    Yu-Ping Zhang; Hong Zhu; Shou-Ming Zhong

    2007-01-01

    This paper concerns the robust non-fragile guaranteed cost control for nonlinear time delay discrete-time systems based on Takagi-Sugeno (T-S) model. The problem is to design a guaranteed cost state feedback controller which can tolerate uncertainties from both models and gain variation. Sufficient conditions for the existence of such controller are given based on the linear matrix inequality (LMI) approach combined with Lyapunov method and inequality technique. A numerical example is given to illustrate the feasibility and effectiveness of our result.

  8. Beta-amyloid overload does not directly correlate with SAPK/JNK activation and tau protein phosphorylation in the cerebellar cortex of Ts65Dn mice.

    Science.gov (United States)

    Lomoio, Selene; Scherini, Elda; Necchi, Daniela

    2009-11-10

    It is known that in the nervous tissue beta-amyloid overproduction and its extracellular or intracellular deposition can activate mitogen-activated protein kinases involved in tau protein phosphorylation. Hyperphosphorylated tau is not more able to bind neuron microtubules, leading to their disassembly and axon degeneration. We have previously described that at 10 months of age in the cerebellum of Ts65Dn mice, which are partially trisomic for the chromosome 16 and are considered a valuable model for Down syndrome, Purkinje cells undergo axon degeneration. Taking into consideration that Ts65Dn mice carry three copies of the gene encoding for the amyloid precursor protein, to characterize potential signaling events triggering the degenerative phenomenon, specific antibodies were used to examine the role of beta-amyloid overload in the activation of the stress activated kinase/c-jun N-terminal kinase (SAPK/JNK) and tau protein phosphorylation in the cerebellar cortex of 12-month-old Ts65Dn mice. We found small extracellular deposits of beta-amyloid at the borderline between the granule cell layer and the white matter, i.e., in the vicinity of the area where calbindin immunostaining of Purkinje cell axons revealed clusters of newly formed terminals of injured axons. Moreover, intracellular deposits were present in the somata of Purkinje cells. The level of activation of SAPK/JNK was greatly increased. The activation occurred in the "pinceaux" made by basket interneuron axons at the axon hillock of Purkinje cells. Antibody directed against tau protein phosphorylated at Ser-396/Ser-404 revealed positive NG2 cells and Bergman fibers in the molecular layer and oligodendrocytes in the white matter. Data indicate that beta-amyloid extracellular deposits could have exerted a local cytotoxic effect, leading to Purkinje cell axon degeneration. The activation of SAPK/JNK in basket cell "pinceaux" may be a consequence of altered functionality of Purkinje cells and may represent

  9. Molecular Cloning of a cDNA Encoding for Taenia solium TATA-Box Binding Protein 1 (TsTBP1) and Study of Its Interactions with the TATA-Box of Actin 5 and Typical 2-Cys Peroxiredoxin Genes.

    Science.gov (United States)

    Rodríguez-Lima, Oscar; García-Gutierrez, Ponciano; Jiménez, Lucía; Zarain-Herzberg, Ángel; Lazzarini, Roberto; Landa, Abraham

    2015-01-01

    TATA-box binding protein (TBP) is an essential regulatory transcription factor for the TATA-box and TATA-box-less gene promoters. We report the cloning and characterization of a full-length cDNA that encodes a Taenia solium TATA-box binding protein 1 (TsTBP1). Deduced amino acid composition from its nucleotide sequence revealed that encodes a protein of 238 residues with a predicted molecular weight of 26.7 kDa, and a theoretical pI of 10.6. The NH2-terminal domain shows no conservation when compared with to pig and human TBP1s. However, it shows high conservation in size and amino acid identity with taeniids TBP1s. In contrast, the TsTBP1 COOH-terminal domain is highly conserved among organisms, and contains the amino acids involved in interactions with the TATA-box, as well as with TFIIA and TFIIB. In silico TsTBP1 modeling reveals that the COOH-terminal domain forms the classical saddle structure of the TBP family, with one α-helix at the end, not present in pig and human. Native TsTBP1 was detected in T. solium cysticerci´s nuclear extract by western blot using rabbit antibodies generated against two synthetic peptides located in the NH2 and COOH-terminal domains of TsTBP1. These antibodies, through immunofluorescence technique, identified the TBP1 in the nucleus of cells that form the bladder wall of cysticerci of Taenia crassiceps, an organism close related to T. solium. Electrophoretic mobility shift assays using nuclear extracts from T. solium cysticerci and antibodies against the NH2-terminal domain of TsTBP1 showed the interaction of native TsTBP1 with the TATA-box present in T. solium actin 5 (pAT5) and 2-Cys peroxiredoxin (Ts2-CysPrx) gene promoters; in contrast, when antibodies against the anti-COOH-terminal domain of TsTBP1 were used, they inhibited the binding of TsTBP1 to the TATA-box of the pAT5 promoter gene.

  10. Nonlinear process generating Tollmien-Schlichting waves in a reattached boundary layer; Hakuri saifuchaku nagare ni okeru T-S hado no hisenkei reiki katei

    Energy Technology Data Exchange (ETDEWEB)

    Asai, M.; Aiba, K. [Tokyo Metropolitan Institute of Technology, Tokyo (Japan)

    1995-09-01

    Low-frequency Tollmien-Schlichting (T-S) waves may be thought generated as a result of high-frequency disturbance between two proximity frequency modes grown unstably in a separation shear layer causing secondary nonlinear interference to occur. This fact has been verified by a numerical simulation. A non-compression Navier-Stokes equation was used for the fundamental equation, a tertiary windward difference for the convection term, and a secondary central difference for other differential calculus. The Reynolds number was 200, and the disturbance was introduced by applying `v` variation continuously on the wall face. Non-introduction of the disturbance results in a steady flow. Disturbance frequencies of 0.15 and 0.20 were selected as disturbance frequencies from the relationship between the spatial amplification and the frequency dependency. The structure of the excited disturbance agreed with the intrinsic mode. The difference mode due to nonlinear interference grows as the basic mode was amplified. The basic mode decays sharply in the boundary layer after reattachment, while the difference mode decays slowly. Distribution of the difference mode is a distribution of viscous T-S waves, which may be converted into the intrinsic mode. 8 refs., 7 figs.

  11. Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype.

    Science.gov (United States)

    Tramutola, Antonella; Pupo, Gilda; Di Domenico, Fabio; Barone, Eugenio; Arena, Andrea; Lanzillotta, Chiara; Broekaart, Diede; Blarzino, Carla; Head, Elizabeth; Butterfield, D Allan; Perluigi, Marzia

    2016-01-01

    Down syndrome (DS) is the most common genetic cause of intellectual disability, resulting from trisomy of chromosome 21. The main feature of DS neuropathology includes early onset of Alzheimer's disease (AD), with deposition of senile plaques and tangles. We hypothesized that apoptosis may be activated in the presence of AD neuropathology in DS, thus we measured proteins associated with upstream and downstream pathways of p53 in the frontal cortex from DS cases with and without AD pathology and from Ts65Dn mice, at different ages. We observed increased acetylation and phosphorylation of p53, coupled to reduced MDM2/p53 complex level and lower levels of SIRT1. Activation of p53 was associated with a number of targets (BAX, PARP1, caspase-3, p21, heat shock proteins, and PGC1α) that were modulated in both DS and DS/AD compared with age-matched controls. In particular, the most relevant changes (increased p-p53 and acetyl-p53 and reduced formation of MDM2/p53 complex) were found to be modified only in the presence of AD pathology in DS. In addition, a similar pattern of alterations in the p53 pathway was found in Ts65Dn mice. These results suggest that p53 may integrate different signals, which can result in a pro-apoptotic-phenotype contributing to AD neuropathology in people with DS.

  12. Expression and biochemical characterization of recombinant α-l-rhamnosidase r-Rha1 from Aspergillus niger JMU-TS528.

    Science.gov (United States)

    Li, Lijun; Yu, Yue; Zhang, Xia; Jiang, Zedong; Zhu, Yanbing; Xiao, Anfeng; Ni, Hui; Chen, Feng

    2016-04-01

    A putative cDNA of α-l-rhamnosidase was PCR-cloned from Aspergillus niger JMU-TS528 and further extracellular over-expressed in Pichia pastoris GS115. The activity of the recombinant α-l-rhamnosidase r-Rha1 was 711.9U/mL, eightfold higher than the native α-l-rhamnosidase from A. niger JMU-TS528. r-Rha1 is a N-glycosylated protein of 90kDa and possesses broad substrate specificities by hydrolyzing α-1,2, α-1,3 α-1,4, and α-1,6 linkages to β-d-glucosides. This is the first report presenting that α-l-rhamnosidase showed activity on four kinds of glucosidic linkages. Compared with other previously characterized α-l-rhamnosidases, r-Rha1 showed a good thermostability and wide range of pH-stability with the optimum pH of 5.0 and temperature of 60°C. r-Rha1 activity was not greatly affected by representative metal ions and other detected effectors and showed excellent tolerance abilities against glucose and ethanol. These beneficial characteristics of r-Rha1 suggest that r-Rha1 should be considered a potential new biocatalyst for food and drug industrial applications.

  13. Tool position tracking control of a nonlinear uncertain flexible robot manipulator by using robust H2/H∞controller via T-S fuzzy model

    Indian Academy of Sciences (India)

    Vahid Azimi; Mohammad Bagher Menhaj; Ahmad Fakharian

    2015-04-01

    In this paper, a robust H2/H∞ control with regional Pole-Placement is considered for tool position control of a nonlinear uncertain flexible robot manipulator. The uncertain nonlinear system is first approximated by Takagi and Sugeno's (T-S) fuzzy model. To achieve a better tracking, an extra state (error of tracking) is then augmented to the T-S model. Based on each local linear subsystem with augmented state, a regional pole-placement state feedback H2/H∞ controller is properly designed via linear matrix inequality (LMI) approach. Parallel Distributed Compensation (PDC) is also used to establish the whole controller for the overall system and the total linear system is obtained by using the weighted sum of the local linear systems. A fuzzy weighted online computation (FWOC) component is employed to update fuzzy weights in real time for different operating points of the system. Simula-tion results are presented to validate the effectiveness of the proposed controller like robustness and good load disturbance attenuation and accurate tracking, even in the presence of parameter variations and also load disturbances on the motor and the tool. The superiority of the proposed control scheme is finally highlighted in comparison with the Quantitative feedback theory (QFT) controller, the QFT controller of order 13, a polynomial controller and the so-called linear sliding-mode controller methods.

  14. FAK tyrosine 407 organized with integrin αVβ5 in Hs578Ts(i)8 advanced triple-negative breast cancer cells.

    Science.gov (United States)

    Payan, Iliet; McDonnell, Susan; Torres, Haydee M; Steelant, Wim F A; Van Slambrouck, Séverine

    2016-05-01

    Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase known to promote cell migration and invasiveness. Overexpression and increased activity of FAK are closely associated with metastatic breast tumors and are linked to poor prognosis. This study discovered an inverse correlation between FAK activity and migratory and invasive behavior. We show decreased phosphorylation levels of FAK at tyrosine residues 397 and 861, and most prominently at Y407, in the more invasive Hs578Ts(i)8 subclone of the Hs578T breast cancer progression model. There is limited information available on FAK Y407, and here we demonstrate its presence in triple-negative breast cancer (TNBC) cell lines. Furthermore, our studies propose that localization of FAK Y407, rather than FAK expression and overall FAK Y407 phosphorylation levels, is crucial for the control of cell motility. FAK Y407 is found extensively at the cell periphery in focal adhesion-like structures at each end of actin stress fibers and organized with integrin αVβ5 receptors, linking the αVβ5 integrin-mediated migratory behavior of Hs578Ts(i)8 cells to FAK Y407. These data suggest that subcellular localization, next to expression and activity levels, are important for understanding TNBC progression. Such an approach opens new avenues for further studies and may provide novel insight for the classification of TNBC and facilitate the discovery of effective biomarkers for diagnosis and therapy of TNBC.

  15. The fermentable organic matter (FOM) as a parameter for evaluating substrates; Die Fermentierbare organische Trockensubstanz (FoTS) als Parameter der Substratbewertung

    Energy Technology Data Exchange (ETDEWEB)

    Weissbach, Friedrich

    2011-07-01

    Biogas yield depends on the gas production potential of the used substrates and on the degree of exploiting this potential by the fermentation process. Therefore, evaluating substrates can only be done based on the gas production potential, regardless of the technology and efficiency of fermentation process. For evaluating this gas production potential of crops and the silages prepared from them, a new parameter is proposed, which is the content of ''Fermentable Organic Matter'' (FOM). This study reports on the development and testing of this parameter under practical conditions. Calculations and tests resulted in the conclusion that a potential yield of about 420 litres methane contained in 800 litres biogas per kg FOM can be assumed for all forage and cereal crops used so far for biogas production. (orig.) [German] Die Biogasausbeute haengt vom Gasbildungspotenzial der eingesetzten Substrate und vom Ausschoepfungsgrad dieses Potenzials im Fermentationsprozess ab. Gegenstand der Bewertung der Substrate kann deshalb nur das von der Gestaltung des Fermentationsprozesses unabhaengige Gasbildungspotenzial sein. Fuer die Bewertung des Gasbildungspotenzials von pflanzlichen Ernteprodukten und von daraus hergestellten Silagen ist ein neuer Parameter vorgeschlagen worden, naemlich der Gehalt an ''Fermentierbarer organischer Trockensubstanz'' (FoTS). Der vorliegende Beitrag informiert ueber die Entwicklung und praktische Erprobung dieser Bewertungsmethode. Als Ergebnis der Arbeiten wurde festgestellt, dass bei allen bisher zur Biogasgewinnung genutzten Halm- und Koernerfruechten mit der gleichen potenzielle Gasausbeute von rund 420 Litern Methan in 800 Litern Biogas je kg FoTS gerechnet werden kann.

  16. Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD).

    Science.gov (United States)

    Alldred, Melissa J; Lee, Sang Han; Petkova, Eva; Ginsberg, Stephen D

    2015-09-01

    Down syndrome (DS) is caused by the triplication of human chromosome 21 (HSA21) and is the most common genetic cause of intellectual disability, with individuals having deficits in cognitive function including hippocampal learning and memory and neurodegeneration of cholinergic basal forebrain neurons, a pathological hallmark of Alzheimer's disease (AD). To date, the molecular underpinnings driving this pathology have not been elucidated. The Ts65Dn mouse is a segmental trisomy model of DS and like DS/AD pathology, displays age-related cognitive dysfunction and basal forebrain cholinergic neuron (BFCN) degeneration. To determine molecular and cellular changes important for elucidating mechanisms of neurodegeneration in DS/AD pathology, expression profiling studies were performed. Molecular fingerprinting of homogeneous populations of Cornu Ammonis 1 (CA1) pyramidal neurons was performed via laser capture microdissection followed by Terminal Continuation RNA amplification combined with custom-designed microarray analysis and subsequent validation of individual transcripts by qPCR and protein analysis via immunoblotting. Significant alterations were observed within CA1 pyramidal neurons of aged Ts65Dn mice compared to normal disomic (2N) littermates, notably in excitatory and inhibitory neurotransmission receptor families and neurotrophins, including brain-derived neurotrophic factor as well as several cognate neurotrophin receptors. Examining gene and protein expression levels after the onset of BFCN degeneration elucidated transcriptional and translational changes in neurons within a vulnerable circuit that may cause the AD-like pathology seen in DS as these individuals age, and provide rational targets for therapeutic interventions.

  17. Micro-matrix solid-phase dispersion coupled with MEEKC for quantitative analysis of lignans in Schisandrae Chinensis Fructus using molecular sieve TS-1 as a sorbent.

    Science.gov (United States)

    Chu, Chu; Wei, Mengmeng; Wang, Shan; Zheng, Liqiong; He, Zheng; Cao, Jun; Yan, Jizhong

    2017-08-24

    A simple and effective method was developed for determining lignans in Schisandrae Chinensis Fructus by using a micro-matrix solid phase dispersion (MSPD) technique coupled with microemulsion electrokinetic chromatography (MEEKC). Molecular sieve, TS-1, was applied as a solid supporting material in micro MSPD extraction for the first time. Parameters that affect extraction efficiency, such as type of dispersant, mass ratio of the sample to the dispersant, grinding time, elution solvent and volume were optimized. The optimal extraction conditions involve dispersing 25mg of powdered Schisandrae samples with 50mg of TS-1 by a mortar and pestle. A grinding time of 150s was adopted. The blend was then transferred to a solid-phase extraction cartridge and the target analytes were eluted with 500μL of methanol. Moreover, several parameters affecting MEEKC separation were studied, including the type of oil, SDS concentration, type and concentration of cosurfactant, and concentration of organic modifier. A satisfactory linearity (R>0.9998) was obtained, and the calculated limits of quantitation were less than 2.77μg/mL. Finally, the micro MSPD-MEEKC method was successfully applied to the analysis of lignans in complex Schisandrae fructus samples. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. A flavonoid agonist of the TrkB receptor for BDNF improves hippocampal neurogenesis and hippocampus-dependent memory in the Ts65Dn mouse model of DS.

    Science.gov (United States)

    Stagni, Fiorenza; Giacomini, Andrea; Guidi, Sandra; Emili, Marco; Uguagliati, Beatrice; Salvalai, Maria Elisa; Bortolotto, Valeria; Grilli, Mariagrazia; Rimondini, Roberto; Bartesaghi, Renata

    2017-09-04

    Intellectual disability is the unavoidable hallmark of Down syndrome (DS), with a heavy impact on public health. Reduced neurogenesis and impaired neuron maturation are considered major determinants of altered brain function in DS. Since the DS brain starts at a disadvantage, attempts to rescue neurogenesis and neuron maturation should take place as soon as possible. The brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a key role in brain development by specifically binding to tropomyosin-related kinase receptor B (TrkB). Systemic BDNF administration is impracticable because BDNF has a poor blood-brain barrier penetration. Recent screening of a chemical library has identified a flavone derivative, 7,8-dihydroxyflavone (7,8-DHF), a small-molecule that crosses the blood-brain barrier and binds with high affinity and specificity to the TrkB receptor. The therapeutic potential of TrkB agonists for neurogenesis improvement in DS has never been examined. The goal of our study was to establish whether it is possible to restore brain development in the Ts65Dn mouse model of DS by targeting the TrkB receptor with 7,8-DHF. Ts65Dn mice subcutaneously injected with 7,8-DHF in the neonatal period P3-P15 exhibited a large increase in the number of neural precursor cells in the dentate gyrus and restoration of granule cell number, density of dendritic spines and levels of the presynaptic protein synaptophysin. In order to establish the functional outcome of treatment, mice were treated with 7,8-DHF from P3 to adolescence (P45-50) and were tested with the Morris Water Maze. Treated Ts65Dn mice exhibited improvement of learning and memory, indicating that the recovery of the hippocampal anatomy translated into a functional rescue. Our study in a mouse model of DS provides novel evidence that treatment with 7,8-DHF during the early postnatal period restores the major trisomy-linked neurodevelopmental defects, suggesting that therapy with 7,8-DHF may represent a

  19. 基于Niche的间接T-S模糊自适应控制%Indirect adaptive control of T-S fuzzy systems based on Niche

    Institute of Scientific and Technical Information of China (English)

    李医民; 郝云力

    2011-01-01

    提出了新的基于生态系统的Niche间接T-S(Takagi-Sugeno)自适应模糊控制,将含有参数的生态位贴近度函数作为模糊规则的后件,从而构成零阶的T-S模糊控制模型.采用Lyapunov合成方法设计控制器,并使用梯度下降法优化后件参数,最后得到了后件参数的自适应律,体现了生物个体的自适应能力,引入了生态位的模糊系统具有生物个体始终朝着有利于自身方向发展的特性.因此,所建立的模糊T-S系统具有更好的自适应性,可以获得更小的变动跟踪误差,并保证整个闭环系统全局稳定性.通过对生态系统的二维捕食系统的仿真验证了本方法的可行性.%A new indirect T-S (Takagi-Sugeno) adaptive fuzzy control based on niche of ecosystems is presented. Regarding the approach degree function of niche with unknown parameters as the consequent of fuzzy ' rules, the zero-order T-S fuzzy control based on niche is constructed. The controller is designed by using the method of Lyapunov's synthesis and the consequent parameters are determined by using a gradient descent method. Finally, the adaptive law of consequent parameters is gotten. The fuzzy system based on niche embodies biological individual's self-adaptivity, namely the individual is evolving in a direction that favors its development. So the proposed fuzzy T-S fuzzy system has better adaptivity, such as obtaining a smaller fluctuant tracking error, and the global stability of the closed-loop system can be assured. Simulation of two-dimensional predator system tracking is carried out to verify the design approach.

  20. TheoReTS - An information system for theoretical spectra based on variational predictions from molecular potential energy and dipole moment surfaces

    Science.gov (United States)

    Rey, Michaël; Nikitin, Andrei V.; Babikov, Yurii L.; Tyuterev, Vladimir G.

    2016-09-01

    Knowledge of intensities of rovibrational transitions of various molecules and theirs isotopic species in wide spectral and temperature ranges is essential for the modeling of optical properties of planetary atmospheres, brown dwarfs and for other astrophysical applications. TheoReTS ("Theoretical Reims-Tomsk Spectral data") is an Internet accessible information system devoted to ab initio based rotationally resolved spectra predictions for some relevant molecular species. All data were generated from potential energy and dipole moment surfaces computed via high-level electronic structure calculations using variational methods for vibration-rotation energy levels and transitions. When available, empirical corrections to band centers were applied, all line intensities remaining purely ab initio. The current TheoReTS implementation contains information on four-to-six atomic molecules, including phosphine, methane, ethylene, silane, methyl-fluoride, and their isotopic species 13CH4 , 12CH3D , 12CH2D2 , 12CD4 , 13C2H4, … . Predicted hot methane line lists up to T = 2000 K are included. The information system provides the associated software for spectra simulation including absorption coefficient, absorption and emission cross-sections, transmittance and radiance. The simulations allow Lorentz, Gauss and Voight line shapes. Rectangular, triangular, Lorentzian, Gaussian, sinc and sinc squared apparatus function can be used with user-defined specifications for broadening parameters and spectral resolution. All information is organized as a relational database with the user-friendly graphical interface according to Model-View-Controller architectural tools. The full-featured web application is written on PHP using Yii framework and C++ software modules. In case of very large high-temperature line lists, a data compression is implemented for fast interactive spectra simulations of a quasi-continual absorption due to big line density. Applications for the TheoReTS may

  1. The Mechanism Analysis of Temperature Regulating Proliferation of Stem Cells Modified by tsSV4OLT Gene%ts-SV40LT抗原转基因干细胞增殖活性的温度调控机制分析

    Institute of Scientific and Technical Information of China (English)

    刘洪良; 刘晓智; 刘振林; 姜忠敏; 盛凤; 李罡

    2012-01-01

    目的:研究温度敏感性猿猴病毒40大T抗原(ts-SV40LT)转基因干细胞增殖活性的温度调控机制.方法:用含ts-SV40LT抗原的表达质粒转染脐带间充质干细胞(UCMSCs),将其分别置于33℃和37℃培养,细胞免疫荧光方法检测增殖细胞核抗原(PCNA)活性,PCR-ELISA端粒酶检测法检测端粒酶活性及细胞周期,Western Blot法检测周期素(Cyclin)D1、CyclinE、周期素依赖性蛋白激酶(CDK)2、CDK4、CDK6、P16和P21的蛋白表达情况,免疫荧光方法检测巢蛋白(Nestin)、神经元特异性烯醇化酶(NSE)和胶质纤维酸性蛋白(GFAP)的表达.结果:细胞在33℃时培养24、48、72 h的PCNA阳性表达百分率均高于37℃时,差异有统计学意义(P<0.01).转染tsSV40LT抗原基因后,细胞在33℃培养箱时的端粒酶活性和Plx值高于37℃时,差异有统计学意义(P<0.01).33℃时的Cyclin D1、CyclinE、CDK2、CDK4、CDK6及Nestin表达量高于37℃时,P16、P21、NSE和GFAP的表达量低于37℃时,差异均有统计学意义(P<0.05或P<0.01).结论:通过tsSV40LT抗原基因的有效转染可实现干细胞在不同温度环境下的增殖调控.%Objective: To study the mechanism of temperature control in proliferation of stem cells modified by tsSV40LT gene temperature-sensitive simian virus 40 large T-antigen (tsSV40LT). Methods: After transfecting plasmid containing tsSV 40 LT into umbilical cord mesenchymal stem cells (UCMSCs). These UCMSCs modified by tsSV40LT were cultured in 33 ℃ and 37 ℃ incubators respectively. The proliferating cell nuclear antigen (PCNA) activity, telomerase activation, cell cycle, cell cycle regulating proteins, including Cyclin D1, Cyclin E, CDK2, CDK4, CDK6, P16, P21, nestin, neurone specific enolase (NSE) and glial fibrillary acidic protein (CFAP) were detected respectively. Results: When cultured at 33 ℃ for 24, 48 and 72 h, the positive percentage of PCNA expression was significantly higher than that of cells cultured in

  2. Stability criteria for T-S fuzzy systems with interval time-varying delays and nonlinear perturbations based on geometric progression delay partitioning method.

    Science.gov (United States)

    Chen, Hao; Zhong, Shouming; Li, Min; Liu, Xingwen; Adu-Gyamfi, Fehrs

    2016-07-01

    In this paper, a novel delay partitioning method is proposed by introducing the theory of geometric progression for the stability analysis of T-S fuzzy systems with interval time-varying delays and nonlinear perturbations. Based on the common ratio α, the delay interval is unequally separated into multiple subintervals. A newly modified Lyapunov-Krasovskii functional (LKF) is established which includes triple-integral terms and augmented factors with respect to the length of every related proportional subintervals. In addition, a recently developed free-matrix-based integral inequality is employed to avoid the overabundance of the enlargement when dealing with the derivative of the LKF. This innovative development can dramatically enhance the efficiency of obtaining the maximum upper bound of the time delay. Finally, much less conservative stability criteria are presented. Numerical examples are conducted to demonstrate the significant improvements of this proposed approach.

  3. Stability Analysis and Stabilization of T-S Fuzzy Delta Operator Systems with Time-Varying Delay via an Input-Output Approach

    Directory of Open Access Journals (Sweden)

    Zhixiong Zhong

    2013-01-01

    Full Text Available The stability analysis and stabilization of Takagi-Sugeno (T-S fuzzy delta operator systems with time-varying delay are investigated via an input-output approach. A model transformation method is employed to approximate the time-varying delay. The original system is transformed into a feedback interconnection form which has a forward subsystem with constant delays and a feedback one with uncertainties. By applying the scaled small gain (SSG theorem to deal with this new system, and based on a Lyapunov Krasovskii functional (LKF in delta operator domain, less conservative stability analysis and stabilization conditions are obtained. Numerical examples are provided to illustrate the advantages of the proposed method.

  4. Three-dimensional topographic index applied to the prediction of acyclic C5-C8 alkenes Kováts retention indices on polydimethylsiloxane and squalane columns.

    Science.gov (United States)

    Ren, Yueying; Liu, Huanxiang; Yao, Xiaojun; Liu, Mancang

    2007-06-29

    A novel approach is described for the prediction of gas chromatographic Kováts retention indices of 150 acyclic C5-C8 alkenes on two stationary phases (polydimethylsiloxane, PDMS, and squalane, SQ). The heuristic method was used to build multiple linear regression models using descriptors calculated by MODLESLAB software and CODESSA program. The resulting quantitative structure-retention relationship (QSRR) models were well-correlated, with predictive R2 values of 0.970 and 0.958 for retention indices on PDMS and SQ columns, respectively. 1Omegap, a three-dimensional (3D) topographic index, was found to play the most important role in the description of the chromatographic retention behavior of the alkenes in these two stationary phases. Moreover, this index could completely distinguish different isomers of alkene. Therefore, it can also be extended to distinguish different isomers of other compounds so that can well describe their quantitative structure-retention relationships.

  5. 对ISO/TS 16949:2002标准6.3.1条款的理解与应用

    Institute of Scientific and Technical Information of China (English)

    吴健康

    2004-01-01

    ISO/TS 16949:2002标准“6.3.1工厂设施及设备策划”条款的要求为:“组织必须采用多方论证的方法来制定工厂、设施及设备的计划。工厂的平面布置必须尽量使材料转移、搬运和对场地空间的增值使用达到最优,同时促进材料的同步流动。必须制定和实施用

  6. Comment on the Nanoparticle Conclusions in Crüts et al. (2008, "Exposure to diesel exhaust induces changes in EEG in human volunteers"

    Directory of Open Access Journals (Sweden)

    Long Christopher M

    2008-07-01

    Full Text Available Abstract A recent publication in this journal reported interesting changes in electroencephalographic (EEG waves that occurred in 10 young, male volunteers following inhalation for one hour of elevated levels of diesel-engine exhaust fumes 1. The authors then proposed a chain of causal events that they hypothesized underlay their observed EEG changes. Their reasoning linked the observed results to nanoparticles in diesel-engine exhaust (DEE, and went on to suggest that associations between changes in ambient particulate matter (PM levels and changes in health statistics might be due to the effects of diesel-engine exhaust (DEE nanoparticles on EEG. We suggest that the extrapolations of the Crüts et al. EEG findings to casual mechanisms about how ambient levels of DEE particulate might affect electrical signals in the brain, and subsequently to how DEE particulate might alter disease risk, are premature.

  7. T-S Fuzzy Model-Based Approximation and Filter Design for Stochastic Time-Delay Systems with Hankel Norm Criterion

    Directory of Open Access Journals (Sweden)

    Yanhui Li

    2014-01-01

    Full Text Available This paper investigates the Hankel norm filter design problem for stochastic time-delay systems, which are represented by Takagi-Sugeno (T-S fuzzy model. Motivated by the parallel distributed compensation (PDC technique, a novel filtering error system is established. The objective is to design a suitable filter that guarantees the corresponding filtering error system to be mean-square asymptotically stable and to have a specified Hankel norm performance level γ. Based on the Lyapunov stability theory and the Itô differential rule, the Hankel norm criterion is first established by adopting the integral inequality method, which can make some useful efforts in reducing conservativeness. The Hankel norm filtering problem is casted into a convex optimization problem with a convex linearization approach, which expresses all the conditions for the existence of admissible Hankel norm filter as standard linear matrix inequalities (LMIs. The effectiveness of the proposed method is demonstrated via a numerical example.

  8. Pharmacological characterisation of α6β4* nicotinic acetylcholine receptors assembled from three different α6/α3 subunit chimeras in tsA201 cells

    DEFF Research Database (Denmark)

    Jensen, Anne Bjørnskov; Hoestgaard-Jensen, Kirsten; Jensen, Anders A.

    2014-01-01

    by their inefficient functional expression in vitro. In the present study we have characterized and compared the pharmacological properties displayed by α6β4 and α6β4β3 nicotinic acetylcholine receptors assembled in tsA201 cells from the classical α6/α3 chimera (C1) and two novel α6/α3 chimeras (C6F223L and C16F223L...... should be made keeping the molecular modifications in the α6 surrogate subunits in mind, this study sheds light on the pharmacological properties of α6β4⁎ nicotinic acetylcholine receptors and demonstrates the applicability of the C6F223L and C16F223L chimeras for studies of these receptors....

  9. One-step Continuous Phenol Synthesis Technology via Selective Hydroxylation of Benzene over Ultrafine TS-1 in a Submerged Ceramic Membrane Reactor☆

    Institute of Scientific and Technical Information of China (English)

    Hong Jiang; Fei She; Yan Du; Rizhi Chen; Weihong Xing

    2014-01-01

    A new route towards phenol production by one-step selective hydroxylation of benzene with hydrogen peroxide over ultrafine titanium silicalites-1 (TS-1) in a submerged ceramic membrane reactor was developed, which can maintain the in situ removal of ultrafine catalyst particles from the reaction slurry and keep the process continuous. The effects of key operating parameters on the benzene conversion and phenol selectivity, as wel as the membrane filtration resistance were examined by single factor experiments. A continuous reaction process was carried out under the obtained optimum operation conditions. Results showed that the system can be continuously and stably operated over 20 h, and the benzene conversion and phenol selectivity kept at about 4%and 91%, respectively. The ceramic membrane exhibits excel ent thermal and chemical stability in the continuous reaction process.

  10. Genetic mapping and biochemical characterization of suppressor mutations sukA and sukB for a dnaK7(Ts) mutation of Escherichia coli K-12.

    Science.gov (United States)

    Itikawa, H; Mishina, Y; Wada, M; Fujita, H

    1992-02-01

    Temperature-resistant pseudorevertants were isolated from a dnaK7(Ts) mutant of Escherichia coli K-12. Two of these pseudorevertants were shown to carry suppressor mutations, sukA and sukB, respectively. Genetic mapping by conjugation and P1-transduction revealed that these suppressor mutations were located at two distinct sites between 76 and 77 min close to the suhA and rpoH genes. Labeled cellular proteins were extracted from suppressor mutants grown at various temperatures and subjected to SDS-gel electrophoresis. Autoradiograms of the gels indicated that these suppressor mutations each resulted in increased synthesis of the heat shock protein Lon (an ATP-dependent protease, La) at both permissive and nonpermissive temperatures.

  11. Travelling TexTs alla Nordic Digital Humanities Conference: Riflessioni sulla situazione di Digital Humanities nell’ottica della storia letteraria finlandese

    Directory of Open Access Journals (Sweden)

    Viola Parente-Čapková

    2016-12-01

    Full Text Available In my contribution, I intend to offer a report on the first conference of Nordic Digital Humanities held in Oslo on March 15-17 2016. I begin with a brief note on the present situation of the discipline, and, following the arguments brought up during the conference, reflect on its existence, development and problems. Then I concentrate on the presentation of the HERA funded Joint Research Project Travelling TexTs 1790–1914: Transnational Reception of Women’s Writing at the Fringes of Europe (Finland, Norway, Slovenia, Spain, The Netherlands and the importance of the digital tool for the project work. I tackle the concept of distant and close reading and comment briefly on the possibilities which such projects offer in terms of new ways of writing and teaching (Finnish literary history.

  12. Potential of time series-hyperspectral imaging (TS-HSI) for non-invasive determination of microbial spoilage of salmon flesh.

    Science.gov (United States)

    Wu, Di; Sun, Da-Wen

    2013-07-15

    This study investigated the potential of using time series-hyperspectral imaging (TS-HSI) in visible and near infrared region (400-1700 nm) for rapid and non-invasive determination of surface total viable count (TVC) of salmon flesh during spoilage process. Hyperspectral cubes were acquired at different spoilage stages for salmon chops and their spectral data were extracted. The reference TVC values of the same samples were measured using standard plate count method and then calibrated with their corresponding spectral data based on two calibration methods of partial least square regression (PLSR) and least-squares support vector machines (LS-SVM), respectively. Competitive adaptive reweighted sampling (CARS) was conducted to identify the most important wavelengths/variables that had the greatest influence on the TVC prediction throughout the whole wavelength range. As a result, eight variables representing the wavelengths of 495 nm, 535 nm, 550 nm, 585 nm, 625 nm, 660 nm, 785 nm, and 915 nm were selected, which were used to reduce the high dimensionality of the hyperspectral data. On the basis of the selected variables, the models of PLSR and LS-SVM were established and their performances were compared. The CARS-PLSR model established using Spectral Set I (400-1000 nm) was considered to be the best for the TVC determination of salmon flesh. The model led to a coefficient of determination (rP(2)) of 0.985 and residual predictive deviation (RPD) of 5.127. At last, the best model was used to predict the TVC values of each pixel within the ROI of salmon chops for visualizing the TVC distribution of salmon flesh. The research demonstrated that TS-HSI technique has a potential for rapid and non-destructive determination of bacterial spoilage in salmon flesh during the spoilage process.

  13. TS-EUROTRAIN: A European-wide investigation and training network on the aetiology and pathophysiology of Gilles de la Tourette Syndrome

    Directory of Open Access Journals (Sweden)

    Natalie J Forde

    2016-08-01

    Full Text Available Gilles de la Tourette Syndrome (GTS is characterised by the presence of multiple motor and phonic tics with a fluctuating course of intensity, frequency and severity. Up to 90% of patients with GTS present with comorbid conditions, most commonly attention-deficit/hyperactivity disorder (ADHD and obsessive-compulsive disorder (OCD, thus providing an excellent model for the exploration of shared aetiology across disorders. TS-EUROTRAIN (FP7-PEOPLE-2012-ITN, Grant Agr.No.316978 is a Marie Curie Initial Training Network (http://ts-eurotrain.eu that aims to elucidate the complex aetiology of the onset and clinical course of GTS, investigate the neurobiological underpinnings of GTS and related disorders, translate research findings into clinical applications and establish a pan-European infrastructure for the study of GTS. This includes the challenges of (i assembling a large genetic database for the evaluation of the genetic architecture with high statistical power; (ii exploring the role of gene-environment interactions including the effects of epigenetic phenomena; (iii employing endophenotype-based approaches to understand the shared aetiology between GTS, OCD and ADHD; (iv establishing a developmental animal model for GTS; (v gaining new insights into the neurobiological mechanisms of GTS via cross-sectional and longitudinal neuroimaging studies; and (vi partaking in outreach activities including the dissemination of scientific knowledge about GTS to the public. Fifteen partners from academia and industry and twelve PhD candidates pursue the project. Our ultimate aims are to elucidate the complex aetiology and neurobiological underpinnings of GTS, translate research findings into clinical applications and establish Pan-European infrastructure for the study of GTS and associated disorders.

  14. Tracking the mutual shaping of the technical and social dimensions of solar-powered mosquito trapping systems (SMoTS) for malaria control on Rusinga Island, western Kenya.

    Science.gov (United States)

    Oria, Prisca A; Hiscox, Alexandra; Alaii, Jane; Ayugi, Margaret; Mukabana, Wolfgang Richard; Takken, Willem; Leeuwis, Cees

    2014-11-18

    There has been increasing effort in recent years to incorporate user needs in technology design and re-design. This project employed a bottom-up approach that engaged end users from the outset. Bottom-up approaches have the potential to bolster novel interventions and move them towards adaptive and evidence-based strategies. The present study concerns an innovative use of solar-powered mosquito trapping systems (SMoTS) to control malaria in western Kenya. Our paper highlights the co-dependence of research associated with the development of the SMoTS technology on one hand and research for enhancing the sustainable uptake of that very same intervention within the community on the other. During the pre-intervention year, we examined the design, re-design and piloting of a novel technology to generate lessons for malaria elimination on Rusinga Island. Initial ideas about many technological necessities were evaluated and re-designed following feedback from various sources, including technical and social research as well as broader interactions with the social environment. We documented the interlocking of the multiple processes and activities that took place through process observation and document reviews. We analysed the data within the conceptual framework of system innovation by identifying mutual shaping between technical and social factors. Our findings illustrate how various project stakeholders including project staff, collaborators, donor, and community members simultaneously pursued interdependent technological transformations and social interests. In the ongoing process, we observed how partial outcomes in the technological domain influenced social events at a later phase and vice versa. Looking at malaria intervention projects employing novel technologies as niches that may evolve towards system innovation, helps to reveal interrelations between the various technical and social aspects. Revealing these interrelations requires a different role for research

  15. 基于T-S模糊模型的机器人轨迹跟踪控制%Robot trajectory tracking control based on T-S fuzzy model

    Institute of Scientific and Technical Information of China (English)

    刘桂林; 高道祥; 闫磊

    2014-01-01

    An adaptive sliding mode controller based on T-S fuzzy model was designed for overcoming the instability resulted from modelling error and perturbation of robotic tracking manipulator. A T-S fuzzy model is established by using sector nonlinear-ity processing for robot dynamic equations. The sliding mode controller is designed to ensure asymptotical stability of robot sys-tem. In the given track experiment of the two-link robot,the system achieved perfect trajectory tracking effect,and the system error was converged to zero rapidly. The results show that the method proposed in this paper has high robust stability for nonlin-ear system. The effectiveness of the method was verified in the experiment.%为了解决机器人跟踪控制的建模误差和扰动所引起的不稳定问题,设计一种基于T-S模糊模型的滑模控制器。首先对机器人动力学方程进行扇区非线性处理,建立T-S模糊模型,然后设计出保证机器人系统渐近稳定的滑模控制器。对二连杆机器人进行给定轨迹实验时,系统具有良好的轨迹跟踪性能,系统误差很快收敛到零。实验结果表明该方法对非线性系统具有较强的鲁棒稳定性,验证了该方法的有效性。

  16. Heraclitean logos and flux in T.S. Eliot’s Four Quartets: 'cosmic consciousness' and 'the still point of the turning world'

    Directory of Open Access Journals (Sweden)

    A. Wessels

    2001-08-01

    Full Text Available T.S. Eliot prefaces “Burnt Norton”, the first of his Four Quartets, with two quotations from the Greek philosopher, Heraclitus. By means of these epigrams, Eliot points us to the Heraclitean opposition and paradoxical interdependence between logos and flux as a paradigm in the poem, a paradigm that he uses for an investigation and articulation of a number of philosophical contemplations. In this paper, I discuss Eliot’s different configurations of the logos/flux paradigm in the poem, firstly to illuminate the relationship between temporality and eternity, secondly, to elaborate the relationship between God and humanity, and thirdly to express the relationship between structured art and chaotic experience. In each instance it is not only the opposition between the two elements that is important, but also the point of contact, the intersection. There is some evidence that Eliot’s depiction of this intersection as, for example, the “moment in and out of time”, is based on personal experience of a transcendent, mystical nature. His expression of this experience is also investigated by comparing it to similar experiences described by others, notably by a Canadian psychiatrist, Richard Maurice Bucke. A comparison of Bucke’s description in his evolutionist text of 1901 and Eliot’s poetic rendering reveals not only surprising similarities but also essential differences which highlights Eliot’s purely Christian interpretation in the face of Bucke’s more universalist approach. For T.S. Eliot, eternity or timelessness can only be accessed through the temporal experience of human consciousness, in fleeting moments of exaltation in daily life, in the charged, timeless configurations of art as an imitation of divine creation, and finally in Christ, who embodies the love of God and is for Eliot the ultimate transection of the temporal and eternal, the flux and the logos.

  17. Knockout of the dhfr-ts gene in Trypanosoma cruzi generates attenuated parasites able to confer protection against a virulent challenge.

    Directory of Open Access Journals (Sweden)

    Cecilia Perez Brandan

    2011-12-01

    Full Text Available BACKGROUND: Trypanosoma cruzi is a protozoan parasite that causes severe disease in millions of habitants of developing countries. Currently there is no vaccine to prevent this disease and the available drugs have the consequences of side effects. Live vaccines are likely to be more effective in inducing protection than recombinant proteins or DNA vaccines; however, safety problems associated to their use have been pointed out. In recent years, increasing knowledge on the molecular genetics of Trypanosomes has allowed the identification and elimination of genes that may be necessary for parasite infectivity and survival. In this sense, targeted deletion or disruption of specific genes in the parasite genome may protect against such reversion to virulent genotypes. METHODS AND FINDINGS: By targeted gene disruption we generated monoallelic mutant parasites for the dhfr-ts gene in a T. cruzi strain that has been shown to be naturally attenuated. In comparison to T. cruzi wild type epimastigotes, impairment in growth of dhfr-ts(+/- mutant parasites was observed and mutant clones displayed decreased virulence in mice. Also, a lower number of T. cruzi-specific CD8(+ T cells, in comparison to those induced by wild type parasites, was detected in mice infected with mutant parasites. However, no remarkable differences in the protective effect of TCC wild type versus TCC mutant parasites were observed. Mice challenged with virulent parasites a year after the original infection with the mutant parasites still displayed a significant control over the secondary infection. CONCLUSION: This study indicates that it is possible to generate genetically attenuated T. cruzi parasites able to confer protection against further T. cruzi infections.

  18. Experimental data report for test TS-4, Reactivity initiated accident test in the NSRR with pre-irradiated BWR fuel rod

    OpenAIRE

    1994-01-01

    本報告書は1991年1月に実施した照射済BWR燃料を用いた4回目の反応度事故模擬実験であるTS-4について、実験データをまとめたものである。TS-4実験に使用した試験燃料は、初期濃縮度2.79%であり、日本原子力発電(株)の敦賀1号炉で照射されたBWR7times7型燃料棒を短尺化したものである。短尺化に供した燃料の燃焼度は26GWd/tUであった。NSRRにおける照射実験は、BWRのコールドスタートアップ条件を模擬した大気圧・室温の静止水冷却条件下で行い、公称発熱量は110pm5cal/g・fuel(ピークエンタルピ89pm4cal/g・fuel)を与えた。その結果、燃料破損は生じなかった。実験条件、実験方法、パルス照射時の燃料の過渡挙動及び照射後検査の結果をまとめて示した。...

  19. Experimental data report for test TS-3; Reactivity initiated accident test in the NSRR with pre-irradiated BWR fuel rod

    OpenAIRE

    1993-01-01

    本報告書は、1990年9月に実施した照射済BWR燃料を用いた3回目の反応度事故模擬実験であるTS-3について実験データをまとめたものである。TS-3実験に使用した試験燃料は初期濃縮度2.79%であり、敦賀1号炉で照射されたBWR7times7型燃料棒を短尺化したものである。短尺化に供した実用燃料のバンドル平均燃焼度は21.3GWd/tUであった。NSRRにおける照射実験は、大気圧・室温の静止水冷却条件下で行い、発熱量は94pm4cal/g・fuel(ピークエンタルピ88pm4cal/g・fuel)を与えた。その結果燃料破損は生じなかった。実験条件、実験方法、パルス照射時の燃料の過渡挙動及び照射後検査の結果をまとめて示した。...

  20. TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome

    Science.gov (United States)

    Forde, Natalie J.; Kanaan, Ahmad S.; Widomska, Joanna; Padmanabhuni, Shanmukha S.; Nespoli, Ester; Alexander, John; Rodriguez Arranz, Juan I.; Fan, Siyan; Houssari, Rayan; Nawaz, Muhammad S.; Rizzo, Francesca; Pagliaroli, Luca; Zilhäo, Nuno R.; Aranyi, Tamas; Barta, Csaba; Boeckers, Tobias M.; Boomsma, Dorret I.; Buisman, Wim R.; Buitelaar, Jan K.; Cath, Danielle; Dietrich, Andrea; Driessen, Nicole; Drineas, Petros; Dunlap, Michelle; Gerasch, Sarah; Glennon, Jeffrey; Hengerer, Bastian; van den Heuvel, Odile A.; Jespersgaard, Cathrine; Möller, Harald E.; Müller-Vahl, Kirsten R.; Openneer, Thaïra J. C.; Poelmans, Geert; Pouwels, Petra J. W.; Scharf, Jeremiah M.; Stefansson, Hreinn; Tümer, Zeynep; Veltman, Dick J.; van der Werf, Ysbrand D.; Hoekstra, Pieter J.; Ludolph, Andrea; Paschou, Peristera

    2016-01-01

    Gilles de la Tourette Syndrome (GTS) is characterized by the presence of multiple motor and phonic tics with a fluctuating course of intensity, frequency, and severity. Up to 90% of patients with GTS present with comorbid conditions, most commonly attention-deficit/hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD), thus providing an excellent model for the exploration of shared etiology across disorders. TS-EUROTRAIN (FP7-PEOPLE-2012-ITN, Grant Agr.No. 316978) is a Marie Curie Initial Training Network (http://ts-eurotrain.eu) that aims to elucidate the complex etiology of the onset and clinical course of GTS, investigate the neurobiological underpinnings of GTS and related disorders, translate research findings into clinical applications, and establish a pan-European infrastructure for the study of GTS. This includes the challenges of (i) assembling a large genetic database for the evaluation of the genetic architecture with high statistical power; (ii) exploring the role of gene-environment interactions including the effects of epigenetic phenomena; (iii) employing endophenotype-based approaches to understand the shared etiology between GTS, OCD, and ADHD; (iv) establishing a developmental animal model for GTS; (v) gaining new insights into the neurobiological mechanisms of GTS via cross-sectional and longitudinal neuroimaging studies; and (vi) partaking in outreach activities including the dissemination of scientific knowledge about GTS to the public. Fifteen partners from academia and industry and 12 PhD candidates pursue the project. Here, we aim to share the design of an interdisciplinary project, showcasing the potential of large-scale collaborative efforts in the field of GTS. Our ultimate aims are to elucidate the complex etiology and neurobiological underpinnings of GTS, translate research findings into clinical applications, and establish Pan-European infrastructure for the study of GTS and associated disorders. PMID:27601976

  1. Stability condition of discrete T-S fuzzy systems%离散T-S模糊系统的稳定条件

    Institute of Scientific and Technical Information of China (English)

    张松涛

    2012-01-01

    For the conservatism problem of stability analysis of T-S fuzzy systems with the common Lyapunov approach, the fuzzy Lyapunov approach and the piecewise fuzzy Lyapunov approach, this paper proposes a sufficient condition to check the stability of open-loop discrete T-S fuzzy systems based on the definition of the efficient maximal overlapped-rules group and the discrete piecewise fuzzy Lyapunov function. This condition only needs satisfying the condition of fuzzy Lyapunov approach in each efficient maximal overlapped-rule group. Therefore, the proposed condition is less conservative and difficult than former three approaches. A simulation example shows the effectiveness and advantage of the approach.%针对应用公共Lyapunov函数方法、模糊Lyapunov函数方法和分段模糊Lyapunov函数方法进行T-S模糊系统稳定性分析的保守性问题,通过定义有效最大交叠规则组,并基于离散型分段模糊Lyapunov函数,提出一个判定开环离散T-S模糊系统稳定性的充分条件.该条件仅需在每个有效最大交叠规则组内分别满足模糊Lyapunov方法中的条件,从而降低上述判定方法的保守性和难度.仿真实例验证了所提出条件的有效性和优越性.

  2. 试论小儿体质特点与多发性抽动症之发病%Discussion on the physical characteristics of children and TS onset

    Institute of Scientific and Technical Information of China (English)

    李向峰; 都修波

    2013-01-01

    Tourette syndrome has become a common pediatric mental and nervous movement disorder disease. The author discusses the relationship between physical characteristics of children and TS onset. To provide ideas and insights for the prevention and treatment of TS with TCM.%多发性抽动症己成为儿科常见的精神及神经运动障碍性疾病。本文探讨了小儿体质特点与多发性抽动症发病之间的关系,为中医药防治TS的研究提供思路和见解。

  3. Inevitable mode of the quality management for machine building%制造业质量管理的必然模式--简析ISO/TS 16949:2002

    Institute of Scientific and Technical Information of China (English)

    吴亦鹏

    2003-01-01

    @@ 由国际汽车特别工作组(IATF)和日本汽车制造商协会(JAMA)在ISO/TC 176质量管理和质量保证委员会组织下制定的ISO/TS 16949:2002《质量管理体系--汽车生产件和相关维修零件组织应用ISO9001:2000的特别要求》于2002年3月14日发布.它代替了ISO/TS 16949:1999.

  4. 钛硅分子筛TS-1的合成、表征及催化性能%Synthesis and Characterization of Titanosilicalite and Its Catalytic Performance

    Institute of Scientific and Technical Information of China (English)

    张义华; 王祥生; 郭新闻; 刘松

    2001-01-01

    The synthesis of titanosilicalite has become a hotspot in the zeolite catalytic fields. In this paper, TS-1 zeolite samples were synthesized with tetrapropyl a mmonium bromide as the template, with ammonia as the base source and with the mi xtu re of titanium tetrachloride and tetrabutyl orthotitanate as the titanium source . The TS-1 samples have excellent catalytic performance in epoxidation of propy lene with aqueous hydrogen peroxide. The samples were characterized by XRD and I R. The introduction of chlorine decreases the association degree of titanium alk oxides and it may prevent preferential segregation of titanium and silicon.

  5. Study on Diverting Automotive Manufacturing Industry Quality Management System to ISO/TS 16949-2002 Technical Standardization%汽车制造业质量管理体系向ISO/TS 16949:2002技术规范转换方案探讨

    Institute of Scientific and Technical Information of China (English)

    张微; 肖飞

    2004-01-01

    行业内已逐推出新的行业认证相关的质量管理体系独特要求,如德国汽车工业的VDA 6.1标准,法国汽车工业的EAQF标准,意大利汽车工业的AVSQ标准,以及美国汽车工业行动集团推出的QS-9000标准,其中以QS-9000和VDA 6.1标准在国内汽车业推行为甚.特别是近4年来,国际汽车特别工作组(IATF)为实现单一的全球质量体系标准和认证过程,与ISO/TC 176组织合作,制定并推出协调化的质量要求--ISO/TS 16949:2002技术规范,目前已经成为多数汽车供应商在质量管理体系方面努力的方向.文章通过对ISO 9001、QS-9000、VDA 6.1标准,以及TS 16949技术规范要求之间的对比分析,包括对国内外汽车制造商对供应商质量体系开发要求的需求调查,探讨质量管理体系向ISO/TS 16949技术规范转换的合理、经济、适用方案,为整车供应链上不同认证状态的企业提供服务和参考.

  6. 猪囊尾蚴排泄分泌抗原Ts881蛋白原核表达条件的优化%Optimization of Prokaryotic Expression of Excretory-secretory Antigen Ts8B1 Protein Gene in Cysticercus cellulosae

    Institute of Scientific and Technical Information of China (English)

    王秋霞; 张美英; 张改平; 王选年; 宁长申; 鲁琨; 张龙现; 菅复春

    2009-01-01

    研究了培养基、温度、诱导时间、IPTG和氨苄青霉素终浓度以及诱导前后温度变化等不同条件对重组菌菌体生长和融合蛋白表达量的影响,以期获得猪囊尾蚴排泄分泌抗原(Es Ag)Ts8 B1蛋白基因在大肠杆菌中的最大表达量.结果显示,使用TB培养基于37℃培养3 h后,采用终浓度为0.2mmol/L的IFrG和200mm0L/L的氨苄青霉素在32℃过夜诱导培养,pGEX-6p-1/TsSBl融合蛋白表达量最大,表达的融合蛋白约占菌体总蛋白的33%.SDS-PAGE表明p(;EX-6p-1/Ts8Bl融合蛋白大小约为33 kDa,与预计的分子量大小一致,Western blot分析表明其能与猪囊尾蚴多克隆抗体起特异性反应,并获得最大产量的融合蛋白.为研究其在猪囊尾蚴病检测中的应用价值奠定了基础.

  7. La depuradora de Begues : reactor biològic o aiguamolls construïts?. Estudi comparatiu dels vectors : paràmetres de l'H2O, fangs produïts, costos capitals i d'explotació, personal

    OpenAIRE

    Gómez Castillo, Jordi

    2010-01-01

    L'objectiu del present estudi és comparar els vectors de paràmetres de l'aigua, producció de fangs, costos i personal entre 2 tipus d'instal·lacions EDAR al municipi de Begues; una ja existent amb tractament secundari i terciari mitjançant un reactor biològic i una potencial amb tractament secundari i terciari mitjançant aiguamolls construïts. La finalitat del projecte és determinar, gràcies a l'estudi dels principals vectors ambientals de la infraestructura i a altres estudiats per na Susana...

  8. Yutong, the first domestic bus enterprise certified by ISO/TS 16949:2002 QMS%宇通成为国内首家获得ISO/TS16949:2002版质量管理体系认证的客车企业

    Institute of Scientific and Technical Information of China (English)

    文风

    2004-01-01

    @@ 日前,宇通已顺利获得了由德国管理体系认证有限公司(DQS)颁发的ISO/TS16949:2002版质量管理体系认证证书.据悉,这是国内首家获此认证的客车企业,它标志着我国客车行业在质量管理方面取得了突破性进展,已经实现与国际同步接轨.

  9. TS-GE72 Jacquard Artificial Fur Machine Serial Real-Time Transmission Pattern of Communication to Achieve%TS-GE72型提花人造毛皮机实时花型传输与显示的实现

    Institute of Scientific and Technical Information of China (English)

    李翔文; 万光逵

    2009-01-01

    文章介绍了Ts-GE72型人造毛皮机的主要功能,详述了新提花毛皮花型文件格式及提花毛皮花型图像实时传输的通讯过程.文中说明了动态显示编织图像的方法.该系统操作简便.实时传输、显示提花毛皮花型图像.花型传输效率高.

  10. Integrated Process of Propylene Epoxidation Catalyzed by TS-1 and H2O2 Production Ⅰ.Influence on Epoxidation of Propylene of Various Reagents in the Anthraquinone Route%TS-1催化丙烯环氧化与H2O2生产过程的集成Ⅰ.蒽醌法中各物质对环氧化反应的影响

    Institute of Scientific and Technical Information of China (English)

    孟祥堃; 李韦; 许锡恩

    2001-01-01

    The influence on the epoxidation of propylene of anthraquinone derivatives, solvents, stabilizers and corrosion resisters used in the anthraquinone route for the production of hydrogen peroxide was investigated. The experimental results show that anthraquinone derivatives and solvents have no obvious influence on the epoxidation of propylene and the deactivation of TS-1. Na2H2P2O7 and NaNO3 used as stabilizer and corrosion resister of hydrogen peroxide have no influence on the epoxidation of propylene and only slight influence on the deactivation of TS-1. H3PO4 lowers the selectivity of propylene oxide, and NH4NO3 lowers both H2O2 conversion and propylene oxide selectivity, they accelerate the process of deactivation of TS-1 catalyst. K2CO3 hydrolyzes propylene oxide to propylene glycol and catalyzes the decomposition of hydrogen peroxide. Trimethylamine catalyzes the reaction of propylene oxide to polyethers, and causes the deactivation of TS-1.%研究了蒽醌法生产H2O2过程中蒽醌衍生物、溶剂、各种添加剂对丙烯环氧化反应的影响。结果表明,在过程集成中,少量蒽醌衍生物及其溶剂,对丙烯环氧化反应及TS-1催化剂失活、再生没有明显的影响;酸性焦磷酸二钠、硝酸钠对环氧化反应没有影响,对TS-1催化剂失活影响不大;磷酸使环氧丙烷选择性降低,硝酸铵使H2O2转化率和环氧丙烷选择性均降低,它们使TS-1催化剂失活加快;碳酸钾使环氧丙烷选择性降低,三甲胺引起TS-1催化剂失活。

  11. 物料浓度(TS)对猪粪厌氧消化的影响%Influence of Material Concentration(TS)On Anaerobic Digestion of Swine Manure

    Institute of Scientific and Technical Information of China (English)

    彭景权; 杨梅; 李裕荣; 刘永霞

    2015-01-01

    Lab - scale experiment was conducted by using anaerobic fermentation devices for 20 liters under room temperature to investigate the influence of swine manure material concentrations(TS) with 1% ,2% ,3% ,2% ,and 6% on anaerobic digestion. The results show that TS and initial COD,TN,TP and NH3 - N in fermented liquid of swine manure are proportional to initial concentra-tion. Until end of test,COD and TN contents are lower than initial concentration while NH3 - N and TP contents are higher than that of initial. Total biogas production increases with the increase of TS, but total biogas production rate is disproportionate to TS. Comprehensively taking factors such as bio-gas starting time,stability,and biogas production rate into consideration,TS of 6% ferments com-pletely. While from the view of resource utilization,TS less than 3% can′t produce biogas continu-ously and take longer to start. In addition,temperature has great influence on anaerobic fermentation for biogas production. The anaerobic digestion process will be terminated if temperature variation am-plitude exceeds + / - 5℃.%在实验室室温条件下,采用20 L 自制厌氧发酵装置,设置物料浓度(TS)分别为1%、2%、3%、4%和6%的猪粪水进行厌氧消化试验,观测其对猪粪厌氧消化的影响。结果表明:猪粪发酵液的 TS 与初始 COD、TN、TP 和 NH3- N 的初始浓度成正比,至试验结束,猪粪 COD 和 TN 含量低于初始浓度,NH3- N 和 TP 含量高于初始浓度。在试验范围内猪粪的总产气量随 TS 升高而增加;但总产气率与 TS 并不成正比。从产气开始时间、稳定度以及产气率综合考虑,TS 6%的猪粪发酵较好;从资源化利用来看,TS 低于3%不利于持续性产气,且启动时间较长。此外,温度对猪粪厌氧发酵产气有较大影响,环境温度变幅超过±5℃时,整个厌氧消化过程停止产气。

  12. ts-SV40LT抗原转基因干细胞增殖活性的温度调控机制分析%The mechanism analysis of temperature regulating proliferation of stem cells modified by ts-SV40LT gene

    Institute of Scientific and Technical Information of China (English)

    涂悦; 刘晓智; 张赛

    2010-01-01

    目的 研究温度敏感性猿猴病毒40大T抗原(ts-SV40LT)转基因干细胞增殖活性的温度调控机制,为实现脑创伤患者在亚低温治疗期间实施干细胞移植奠定基础.方法 用含ts-SV40LT抗原的表达质粒转染人源性脐带间充质干细胞(UCMSCs),PCR方法 检测外源基因的整合效率,将其分别置于亚低温(33℃)和正常体温(37℃)下培养,细胞免疫荧光方法 检测增殖细胞核抗原(PCNA)活性,PCR-ELISA端粒酶检测法检测端粒酶活性,流式细胞术检测细胞周期,Western blot法检测细胞周期调控蛋白--周期素D1(Cyclin D1)、CyclinE、周期素依赖性蛋白激酶-2(CDK2)、CDK4、CDK6、P16和P21的蛋白表达情况,免疫荧光方法 检测巢蛋白(nestin)、神经元特异性烯醇化酶(NSE)和胶质纤维酸性蛋白(GFAP)的表达;SPSS13.0软件进行统计学分析.结果 PCR结果 显示ts-SV40LT抗原的基因片段被成功整合入干细胞,该细胞株在33℃条件下增殖生长旺盛,端粒酶活性高,Cyclin D1、CyclinE、CDK2、CDK4、CDK6均高表达,P16和P21低表达,同时高表达nestin,不表达NSE和GFAP;在37℃条件下细胞增殖缓慢甚至停滞,端粒酶活性低,Cyclin D1、CyclinE、CDK2、CDK4、CDK6的表达强度明显低于33℃条件,P16和P21则相反,与此同时nestin表达强度明显下降,NSE和GFAP表达水平上升.结论 通过ts-SV40LT抗原基因的有效转染可实现干细胞在不同温度环境下的增殖调控,为在亚低温条件下实现干细胞移植救治颅脑创伤患者提供了实验支持.%Objective To study the mechanism of temperature control proliferation of the stem cells modified by ts - SV40LT gene for establishing a basement on stem cells transplantation into injured brain area during hypothermia treatment. Methods After transfecting plasmid containing temperature - sensitive simian virus 40 large T - antigen (ts - SV40LT) into umbilical cord mesenchymal stem cells (UCMSCs), PCR method was used to

  13. Effective Management of an Advanced Gastric Cancer Patient by TS-1 Combined Chemotherapy Using Nasojejunal Tube and Successful Transfer to Home Care after Percutaneous Transesophageal Gastro-tubing (PTEG: A Case Report

    Directory of Open Access Journals (Sweden)

    Miyade,Yoshio

    2010-02-01

    Full Text Available A 67-year-old woman with debilitation and massive ascites was admitted to our hospital and diagnosed with stage IV scirrhous gastric cancer with peritoneal dissemination. After successful nasojejunal tube feeding because of oral intake disability, TS-1 combined with paclitaxel chemotherapy was selected. TS-1 at 80mg/m2 was given daily via nasojejunal tube for 2 weeks, followed by a 1-week rest, and paclitaxel at 50mg/m2 was administered intravenously on day 1 and 8. There were no serious side effects. After 4 cycles, a partial response was observed and percutaneous transesophageal gastro-tubing (PTEG was placed. After the fifth cycle, she was transferred to her home and received chemotherapy in an outpatient clinic. After 7 cycles, the disease progressed, and TS-1 combined with low-dose cisplatin was administered for 3 cycles. However, the patient died 16 weeks after discharge. PTEG was useful not only for a route of TS-1 administration, but also for receiving chemotherapy at home to maintain her quality.

  14. 创立IS0/TS 16949认证民族品牌北京九鼎国联汽车管理体系认证有限责任公司获IATF正式授权

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ 北京九鼎国联汽车管理体系认证有限责任公司(CASC)于2005年11月2日与国际汽车特别工作组(IATF)正式签署了ISO/TS 16949认证授权协议,成为国内第一家与IATF签约的认证机构.这标志着中国有了自己的ISO/TS 16949认证机构,中国的管理体系认证机构完成了从QS 9000认证向ISO/TS 16949认证的飞跃,实现了与国际汽车认证的同步接轨,填补了国内认证机构在该领域的空白,中国的认证机构只能分包与IATF签约的国外认证机构的ISO/TS 16949认证业务而不能独立颁发自己的认证证书的历史就此终结.这是国家认监委促进汽车业管理体系认证国际合作的又一成果.

  15. Road accidents at night in the Netherlands : a national analysis according to official road accident data. Contribution to OECD Research Group TS 3 on Improving Road Safety at Night.

    NARCIS (Netherlands)

    Harris, S.

    1979-01-01

    The questionnaire about night-time accident data of the OECD Research Group TS 3 on Improving Road Safety at Night was filled in for the Netherlands. Thereafter a national analysis was written, using the already completed accident data questionnaire. Guidelines for the contents and presentation fo

  16. 基于TS模糊控制的双馈风力发电机低电压穿越技术研究%Research on LVRT for wind turbine with DFIG based on TS-fuzzy controller

    Institute of Scientific and Technical Information of China (English)

    王兴贵; 夏岩; 马呈霞; 郑伟

    2011-01-01

    建立了变速恒频双馈感应风力发电机数学模型.为提高双馈感应发电机(Double Fed Induction Geneator,DFIG)机组的低电压穿越(LVRT)能力,设计了Takagi Sugeno(TS)模糊PI控制器.以某风电场为对象建立了DFIG多机互联仿真模型.仿真结果表明,相比传统PI控制器,TS模糊PI控制器可以有效抑制电网故障时DFIG有功功率和变流器直流母线电压震荡,从而提高系统的低电压穿越能力.%Modle of variable speed constant frequency double fed wind power system is established. The application of Takagi Sugeno (TS) fuzzy controllers for improving LVTR capacity of DFIG is proposed. The muiti-machine DFIG simulation model of a practical wind farm is built. The simulation results show the effectiveness of the TS fuzzy controller by restraining oscillations of the active power output and DC bus capacitor voltage in condition of large external voltage dip. The proposed TS-fuzzy controller can improve the low voltage ride through capability of power system compared with the conventional PI controller.

  17. A Comparative Image Study of two Love Songs-The Sun Rising by John Donne and The Love Song of J.Alfred Prufrock by T.S Eliot

    Institute of Scientific and Technical Information of China (English)

    刘璨

    2013-01-01

    The Sun Rising is one of the most famous metaphysical poems of John Donne. The Love Song of J.Alfred Prufrock is known as the first Modernist poem of T.S Eliot. This paper mainly aims to analyze the strikingly unconventional images use in the two poems, and make comments on their effect on expressing the poet emotions.

  18. Expressions and clinical significances of TS and PCNA in cervical intraepithelial neoplasia and cervical carcinoma%宫颈上皮内瘤变及宫颈癌中TS、PCNA的表达及其意义

    Institute of Scientific and Technical Information of China (English)

    郑巧荣; 崔金全

    2011-01-01

    目的:探讨胸苷酸合成酶(thymidylate synthase,TS)在宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)及宫颈癌发生、发展中的作用及与预后的关系.方法:采用免疫组化SP法检测TS、增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)在慢性宫颈炎、宫颈上皮内瘤变及宫颈癌中的表达.结果:与慢性宫颈炎相比,CIN及宫颈癌中 TS 的表达率明显增高(P值分别为0.006、0.004);而CIN与宫颈癌组比较,差异无统计学意义(P=0.780);CIN各组之间差异亦无显著性.在宫颈癌中,TS的表达与临床分期、淋巴结转移有关(P值分别为0.033、0.015),与细胞分化程度及肌层浸润深度无关(P值分别为0.343、0.350).PCNA在CIN和宫颈癌中的表达率明显高于慢性宫颈炎(P值分别为0.029、0.000),在宫颈癌中的表达率也明显高于CIN(P值为0.000).在CIN和宫颈癌中,TS和PCNA的表达存在关联性(Pearson列联系数=0.319 6,x2=8.371,P<0.005).结论:TS作为一种促细胞增殖的蛋白与宫颈病变的发生有一定关系,对预测宫颈癌的预后有一定参考价值.%Objective: To explore the role of thymidylate synthase (TS) in occurrence and development of cervical intraepithelial neoplasia (CIN) and cervical carcinoma and its relationship with prognosis.Methods: Immunohistochemical SP method was used to detect the expression levels of TS and proliferating cell nuclear antigen (PCNA) in chronic cervicitis, CIN and cervical carcinoma.Results: Compared with chronic cervicitis group, the expression rates of TS in CIN group and cervical carcinoma group increased significantly ( P = 0.006,0.004, respectively).There was no significant difference in expression rate of TS between CIN group and cervical carcinoma group ( P =0.780); there was no significant difference in expression rate of TS among subgroups of CIN group; in cervical carcinoma group, the expression of TS correlated with clinical stages ( P = 0.033 ) and lymph node

  19. 基于改进T-S模糊神经网络的交通流量预测%Traffic Flow Prediction Based on Improved T-S Fuzzy Neural Network

    Institute of Scientific and Technical Information of China (English)

    侯越

    2014-01-01

    在萤火虫优化算法和T-S模糊神经网络的基础上,提出了一种采用萤火虫算法优化的T-S模糊神经网络预测交通流量的算法。该算法利用萤火虫算法得到T-S模糊神经网络的最优参数配置,从而能发挥T-S模糊神经网络泛化的映射能力。将该算法应用到实测交通流中进行算法的有效性验证,并与传统的T-S模糊神经网络和遗传算法优化的T-S模糊神经网络进行比较,仿真结果表明该算法具有更高的预测准确性,从而证明了该算法在交通流量预测领域的可行性和有效性。%Based on the glowworm swarm optimization (GSO) and T-S fuzzy neural network (TSFNN), this paper proposes a prediction algorithm for traffic flow of T-S fuzzy neural network optimized glowworm swarm optimiza-tion (GSOTSFNN). The proposed algorithm uses GSO to get the optimal parameter configuration, thus can perform mapping ability of T-S fuzzy neural network for generalization. The efficiency of the proposed prediction algorithm is tested by the simulation of real traffic flow. The simulation results show that the proposed algorithm has higher forecasting accuracy compared with the traditional T-S fuzzy neural network and T-S fuzzy neural network opti-mized genetic algorithm, so it is feasible and effective in the practical prediction of traffic flow.

  20. Utilization of a ts-sacB selection system for the generation of a Mycobacterium avium serovar-8 specific glycopeptidolipid allelic exchange mutant

    Science.gov (United States)

    Irani, Vida R; Lee, Sun-Hwa; Eckstein, Torsten M; Inamine, Julia M; Belisle, John T; Maslow, Joel N

    2004-01-01

    Background Mycobacterium avium are ubiquitous environmental organisms and a cause of disseminated infection in patients with end-stage AIDS. The glycopeptidolipids (GPL) of M. avium are proposed to participate in the pathogenesis of this organism, however, establishment of a clear role for GPL in disease production has been limited by the inability to genetically manipulate M. avium. Methods To be able to study the role of the GPL in M. avium pathogenesis, a ts-sacB selection system, not previously used in M. avium, was employed as a means to achieve homologous recombination for the rhamnosyltransferase (rtfA) gene of a pathogenic serovar 8 strain of M. avium to prevent addition of serovar-specific sugars to rhamnose of the fatty acyl-peptide backbone of GPL. The genotype of the resultant rtfA mutant was confirmed by polymerase chain reaction and southern hybridization. Disruption in the proximal sugar of the haptenic oligosaccharide resulted in the loss of serovar specific GPL with no change in the pattern of non-serovar specific GPL moieties as shown by thin layer chromatography and gas chromatography/mass spectrometry. Complementation of wild type (wt) rtfA in trans through an integrative plasmid restored serovar-8 specific GPL expression identical to wt serovar 8 parent strain. Results In this study, we affirm our results that rtfA encodes an enzyme responsible for the transfer of Rha to 6d-Tal and provide evidence of a second allelic exchange mutagenesis system suitable for M. avium. Conclusion We report the second allelic exchange system for M. avium utilizing ts-sacB as double-negative and xylE as positive counter-selection markers, respectively. This system of allelic exchange would be especially useful for M. avium strains that demonstrate significant isoniazid (INH) resistance despite transformation with katG. Through the construction of mutants in GPL or other mycobacterial components, their roles in M. avium pathogenesis, biosynthesis, or drug

  1. Utilization of a ts-sacB selection system for the generation of a Mycobacterium avium serovar-8 specific glycopeptidolipid allelic exchange mutant

    Directory of Open Access Journals (Sweden)

    Belisle John T

    2004-09-01

    Full Text Available Abstract Background Mycobacterium avium are ubiquitous environmental organisms and a cause of disseminated infection in patients with end-stage AIDS. The glycopeptidolipids (GPL of M. avium are proposed to participate in the pathogenesis of this organism, however, establishment of a clear role for GPL in disease production has been limited by the inability to genetically manipulate M. avium. Methods To be able to study the role of the GPL in M. avium pathogenesis, a ts-sacB selection system, not previously used in M. avium, was employed as a means to achieve homologous recombination for the rhamnosyltransferase (rtfA gene of a pathogenic serovar 8 strain of M. avium to prevent addition of serovar-specific sugars to rhamnose of the fatty acyl-peptide backbone of GPL. The genotype of the resultant rtfA mutant was confirmed by polymerase chain reaction and southern hybridization. Disruption in the proximal sugar of the haptenic oligosaccharide resulted in the loss of serovar specific GPL with no change in the pattern of non-serovar specific GPL moieties as shown by thin layer chromatography and gas chromatography/mass spectrometry. Complementation of wild type (wt rtfA in trans through an integrative plasmid restored serovar-8 specific GPL expression identical to wt serovar 8 parent strain. Results In this study, we affirm our results that rtfA encodes an enzyme responsible for the transfer of Rha to 6d-Tal and provide evidence of a second allelic exchange mutagenesis system suitable for M. avium. Conclusion We report the second allelic exchange system for M. avium utilizing ts-sacB as double-negative and xylE as positive counter-selection markers, respectively. This system of allelic exchange would be especially useful for M. avium strains that demonstrate significant isoniazid (INH resistance despite transformation with katG. Through the construction of mutants in GPL or other mycobacterial components, their roles in M. avium pathogenesis

  2. Experimental data report for test TS-5; Reactivity initiated accident test in the NSRR with pre-irradiated BWR fuel rod

    OpenAIRE

    1995-01-01

    本報告書は、1993年度1月に実施した照射済BWR燃料を用いた5回目の反応度事故模擬実験であるTS-5について、実験データをまとめたものである。TS-4実験に使用した試験燃料は、初期濃縮度2.79%であり、日本原子力発電(株)の敦賀1号炉で照射されたBWR7times7型燃料棒を短尺化したものである。短尺化に供した燃料の燃焼度は26GWd/tUであった。NSRRにおける照射実験は、BWRのコールドスタートアップ条件を模擬した大気圧・室温の静止水冷却条件下で行い、公称発熱量は117pm5cal/g・fuel(ピークエンタルピ98pm4cal/g・fuel)を与えた。その結果燃料破損は生じなかった。なお、この実験では集合体中の燃料/水比を模した流路管中で燃料のパルス照射を行った。実験条件、実験方法、パルス照射時の燃料の過渡挙動及び照射後検査の結果をまとめて示した。...

  3. Estimation of ash recirculation effect upon ash collector efficiency by the example of a TsBR-150U-1280 multicyclone collector

    Science.gov (United States)

    Elsukov, V. K.; Latushkina, S. V.

    2014-10-01

    Problems of the mathematical estimation of the amount of recirculating ash and its effect upon the efficiency of gas treating within ash collectors with the scroll and semiscroll gas supply, which are equipped by a gas and ash recirculation system, are considered. Based on the analysis of various publications and operational experience, a conclusion is drawn regarding the complex and substantial effect of the recirculation system upon the ash collector efficiency. The following research tasks are posed: computational determination of ash weight at the ash collector inlet subject to its recirculation, development of measures for enhancement of the ash collector, and estimation of these measures. A computation procedure for consumption of recirculating ash in the ash collector and its sections with the use of formulas of the geometrical progression is represented. Based on the represented procedure as applied to a TsBR-150U-1280 multicyclone collector collecting ash of coal of an Irsha-Borodinsk coalfield, corresponding ash consumptions are determined, including that at which the effective operation of the ash collector is provided. Various variants of the modernization of the mentioned multicyclone collector are developed and estimated. Conclusions are drawn regarding the necessity for further investigations for improvement of the represented procedure, in particular, the effect of the gas speed (boiler load) upon the efficiency of various ash collector units, recirculating ash consumption, and clogging their cyclone units.

  4. An improved FEM model for computing transport AC loss in coils made of RABiTS YBCO coated conductors for electric machines

    Science.gov (United States)

    Ainslie, Mark D.; Rodriguez-Zermeno, Victor M.; Hong, Zhiyong; Yuan, Weijia; Flack, Timothy J.; Coombs, Timothy A.

    2011-04-01

    AC loss can be a significant problem for any applications that utilize or produce an AC current or magnetic field, such as an electric machine. The authors investigate the electromagnetic properties of high temperature superconductors with a particular focus on the AC loss in superconducting coils made from YBCO coated conductors for use in an all-superconducting electric machine. This paper presents an improved 2D finite element model for the cross-section of such coils, based on the H formulation. The model is used to calculate the transport AC loss of a racetrack-shaped coil using constant and magnetic field-dependent critical current densities, and the inclusion and exclusion of a magnetic substrate, as found in RABiTS (rolling-assisted biaxially textured substrate) YBCO coated conductors. The coil model is based on the superconducting stator coils used in the University of Cambridge EPEC Superconductivity Group's all-superconducting permanent magnet synchronous motor design. To validate the modeling results, the transport AC loss of a stator coil is measured using an electrical method based on inductive compensation by means of a variable mutual inductance. Finally, the implications of the findings on the performance of the motor are discussed.

  5. Increased excitability and altered action potential waveform in cerebellar granule neurons of the Ts65Dn mouse model of Down syndrome.

    Science.gov (United States)

    Usowicz, Maria M; Garden, Claire L P

    2012-07-17

    Down syndrome (DS) is characterized by intellectual disability and impaired motor control. Lack of coordinated movement, poor balance, and unclear speech imply dysfunction of the cerebellum, which is known to be reduced in volume in DS. The principal cause of the smaller cerebellum is a diminished number of granule cells (GCs). These neurons form the 'input layer' of the cerebellar cortex, where sensorimotor information carried by incoming mossy fibers is transformed before it is conveyed to Purkinje cells and inhibitory interneurons. However, it is not known how processing of this information is affected in the hypogranular cerebellum that characterizes DS. Here we explore the possibility that the electrical properties of the surviving GCs are changed. We find that in the Ts65Dn mouse model of DS, GCs have a higher input resistance at voltages approaching the threshold for firing, which causes them to be more excitable. In addition, they fire narrower and larger amplitude action potentials. These subtly modified electrical properties may result in atypical transfer of information at the input layer of the cerebellum.

  6. TsAg5, a Taenia solium cysticercus protein with a marginal trypsin-like activity in the diagnosis of human neurocysticercosis.

    Science.gov (United States)

    Rueda, Analiz; Sifuentes, Cecilia; Gilman, Robert H; Gutiérrez, Andrés H; Piña, Ruby; Chile, Nancy; Carrasco, Sebastián; Larson, Sandra; Mayta, Holger; Verástegui, Manuela; Rodriguez, Silvia; Gutiérrez-Correa, Marcel; García, Héctor H; Sheen, Patricia; Zimic, Mirko

    2011-12-01

    Neurocysticercosis is an endemic parasitic disease caused by Taenia solium larva. Although the mechanism of infection is not completely understood, it is likely driven by proteolytic activity that degrades the intestinal wall to facilitate oncosphere penetration and further infection. We analyzed the publicly available T. solium EST/DNA library and identified two contigs comprising a full-length cDNA fragment very similar to Echinococcus granulosus Ag5 protein. The T. solium cDNA sequence included a proteolytic trypsin-like-domain in the C-terminal region, and a thrombospondin type-1 adherence-domain in the N-terminal region. Both the trypsin-like and adherence domains were expressed independently as recombinant proteins in bacterial systems. TsAg5 showed marginal trypsin-like activity and high sequence similarity to Ag5. The purified antigens were tested in a Western immunoblot assay to diagnose human neurocysticercosis. The sensitivity of the trypsin-like-domain was 96.36% in patients infected with extraparenchymal cysts, 75.44% in patients infected with multiple cysts, and 39.62% in patients with a single cyst. Specificity was 76.70%. The thrombospondin type-1 adherence-domain was not specific for neurocysticercosis.

  7. Robust Fault Estimation for a Class of T-S Fuzzy Singular Systems with Time-Varying Delay via Improved Delay Partitioning Approach

    Directory of Open Access Journals (Sweden)

    Chao Sun

    2016-01-01

    Full Text Available The problem of delay-dependent robust fault estimation for a class of Takagi-Sugeno (T-S fuzzy singular systems is investigated. By decomposing the delay interval into two unequal subintervals and with a new and tighter integral inequality transformation, an improved delay-dependent stability criterion is given in terms of linear matrix inequalities (LMIs to guarantee that the fuzzy singular system with time-varying delay is regular, impulse-free, and stable firstly. Then, based on this criterion, by considering the system fault as an auxiliary disturbance vector and constructing an appropriate fuzzy augmented system, a fault estimation observer is designed to ensure that the error dynamic system is regular, impulse-free, and robustly stable with a prescribed H∞ performance satisfied for all actuator and sensor faults simultaneously, and the obtained fault estimates can practically better depict the size and shape of the faults. Finally, numerical examples are given to show the effectiveness of the proposed approach.

  8. Chemical surface treatment with toluene to enhance sensitivity of NO2 gas sensors based on CuPcTs/Alq3 thin films

    Directory of Open Access Journals (Sweden)

    Mahdi H. Suhail

    2017-09-01

    Full Text Available A nitrogen dioxide (NO2 gas sensor based on the blend of copper phthalocyanine-tetrasulfonic acid tetrasodium/tris-(8-hydroxyquinolinealuminum (CuPcTs/Alq3 thin films was fabricated. The effect of chemical surface treatment with toluene on the structural, surface morphology and device sensitivity has been examined. The X-ray diffraction (XRD patterns of as-deposited and toluene-treated films exhibit a broad hump peak at 2θ = 24°. The atomic force microscopy (AFM measurements show that the average particle diameter decreases with immersing time. The needle like shapes can be seen from scanning electron microscopy (SEM images for films treated with toluene for an immersing time of 60 min. Gas sensor characterizations demonstrate that all samples have superior NO2 gas sensitivity at a operating temperature of 373 K. The increase of the sensor sensitivity with increasing chemical treatment time up to 60 min was observed. All films show the stable and repeatable response patterns.

  9. Statistical characterization of three grades of large billet-graphites: Stackpole 2020, Union Carbide TS1792, and Toyo Tanso IG11

    Energy Technology Data Exchange (ETDEWEB)

    Kennedy, C R

    1987-09-01

    Large billets of three fine-grained, isostatically molded graphites (three billets each of grade TS1792 from Union Carbide Corporation, six billets of grade IG11 from Toyo Tanso, and thirteen billets of grade 2020 from Stackpole Corporation) were evaluated by nondestructive methods, and the results were analyzed. The results of sonic testing were shown to be interrelated to both the mean and variance of strenth obtained from destructive testing. The virtue of the nondestructive evaluation is clearly illustrated by the practical ability to evaluate up to 100% of the billet volume, thus giving a more accurate description of the materials' mechanical properties. It was shown that the randomness of the mean strength in these billets makes it very unlikely that test results from small-sample volumes removed from the billet will be representative of the billet as a whole. In critical applications requiring a high level of quality assurance, a more complete nondestructive evaluation of the billet appears to be required.

  10. Enhanced Cr bioleaching efficiency from tannery sludge with coinoculation of Acidithiobacillus thiooxidans TS6 and Brettanomyces B65 in an air-lift reactor.

    Science.gov (United States)

    Fang, Di; Zhou, Li-Xiang

    2007-09-01

    Bioleaching process has been demonstrated to be an effective technology in removing Cr from tannery sludge, but a large quantity of dissolved organic matter (DOM) present in tannery sludge often exhibits a marked toxicity to chemolithoautotrophic bioleaching bacteria such as Acidithiobacillus thiooxidans. The purpose of the present study was therefore to enhance Cr bioleaching efficiencies through introducing sludge DOM-degrading heterotrophic microorganism into the sulfur-based sludge bioleaching system. An acid-tolerant DOM-degrading yeast strain Brettanomyces B65 was successfully isolated from a local Haining tannery sludge and it could metabolize sludge DOM as a source of energy and carbon for growth. A combined bioleaching experiment (coupling Brettanomyces B65 and A. thiooxidans TS6) performed in an air-lift reactor indicated that the rates of sludge pH reduction and ORP increase were greatly improved, resulting in enhanced Cr solubilization. Compared with the 5 days required for maximum solubilization of Cr for the control (single bioleaching process without inoculation of Brettanomyces B65), the bioleaching period was significantly shorten to 3 days for the combined bioleaching system. Moreover, little nitrogen and phosphorous were lost and the content of Cr was below the permitted levels for land application after 3 days of bioleaching treatment.

  11. TsAg5, a Taenia solium cysticercus protein with a marginal trypsin-like activity in the diagnosis of human neurocysticercosis

    Science.gov (United States)

    Rueda, Analiz; Sifuentes, Cecilia; Gilman, Robert H.; Gutiérrez, Andrés H.; Piña, Ruby; Chile, Nancy; Carrasco, Sebastián; Larson, Sandra; Mayta, Holger; Verástegui, Manuela; Rodriguez, Silvia; Gutiérrez-Correa, Marcel; García, Héctor H.; Sheen, Patricia; Zimic, Mirko

    2011-01-01

    Neurocysticercosis is an endemic parasitic disease caused by Taenia solium larva. Although the mechanism of infection is not completely understood, it is likely driven by proteolytic activity that degrades the intestinal wall to facilitate oncosphere penetration and further infection. We analyzed the publicly available Taenia solium EST/DNA library and identified two contigs comprising a full-length cDNA fragment very similar to E. granulosus Ag5 protein. The Taenia solium cDNA sequence included a proteolytic trypsin-like-domain in the C-terminal region, and a thrombospondin type-1 adherence-domain in the N-terminal region. Both the trypsin-like and adherence domains were expressed independently as recombinant proteins in bacterial systems. TsAg5 showed marginal trypsin-like activity and high sequence similarity to Ag5. The purified antigens were tested in a Western immunoblot assay to diagnose human neurocysticercosis. The sensitivity of the trypsin-like-domain was 96.36% in patients infected with extraparenchymal cysts, 75.44% in patients infected with multiple cysts, and 39.62% in patients with a single cyst. Specificity was 76.70%. The thrombospondin type-1 adherence-domain was not specific for neurocysticercosis. PMID:21893105

  12. 中国重汽济南商用车公司通过ISO/TS16949质量管理体系现场认证审核

    Institute of Scientific and Technical Information of China (English)

    李光耀

    2007-01-01

    2007年8月25日,TUV北德认证(天津)有限公司的认证审核组,在经过6天的现场认证审核后郑重宣布:中国重汽集团济南商用车有限公司通过ISO/TS 16949质量管理体系现场认证审核:使该公司成为国内商用车行业首家通过ISO/TS16949质量管理体系认证的整车生产厂家,

  13. New edition of ISO/TS 16949 quality specification for automotive industry supply chain%新ISO标准关于汽车行业供应链的质量规范

    Institute of Scientific and Technical Information of China (English)

    尹冬梅

    2009-01-01

    @@ ISO最近发布的新版ISO/TS 16949:2009,明确了供应商在汽车行业的质量体系要求. ISO/TS16949:2009,质量管理系统--ISO 9001:2008应用在汽车生产和相关服务部分组织的特别要求,取代了主要汽车制造商使用的2002年版,以批准超过35000个生产和供应零部件给该领域在世界各地的组织.

  14. Quantum yield for O-atom production in the VUV photodissociation of CO2 using the time-sliced velocity-mapped imaging (TS-VMI) method

    Science.gov (United States)

    Jackson, William M.

    2016-10-01

    VUV photodissociation above 10.5 eV is considered the primary region for photochemical destruction of CO2 by solar radiation. There is enough photon energy in this region so that in addition to ground state O(3PJ) and CO(1Σ +) that can be produced during photodissociation excited species such as atomic oxygen O(1D) and O(1S), as well as excited carbon monoxide CO(a3Π, a'3Σ+) also can be formed. Electronic excited oxygen atom and carbon monoxide are the species that are responsible for the airglows in atmospheres of the solar planets and comets. Therefore, detail photodissociation quantum yields for these excited species from CO2 are critical in interpreting the chemistry in these solar system bodies. We have previously shown that the time-sliced velocity-mapped imaging (TS-VMI) technique can provide detailed branching ratio information about photodissociation of diatomic molecules.1, 2 However, to date we have not been able to show how this technique can be use to determine absolute quantum yields for the products produced in the VUV photodissociation of CO2. In this talk we will describe how the known quantum yields for the photodissociation O2 to O(3P2), O(3P1), O(3P0) and O(1D) can be used to determine quantum yields of similar products in the photodissociation of CO2.[1] Yu Song, Hong Gao, Yih Chung Chang, D. Hammouténe, H. Ndome, M. Hochlaf, William M. Jackson, and C. Y. Ng, Ap. J., 819:23 (13pp), 2016; doi:10.3847/0004-637X/819/1/23.[2] Hong Gao, Yu Song, William M. Jackson and C. Y. Ng, J. Chem. Phys, 138, 191102, 2013.

  15. Influence of ecological factors on the production of active substances in the anti-cancer plant Sinopodophyllum hexandrum (Royle T.S. Ying.

    Directory of Open Access Journals (Sweden)

    Wei Liu

    Full Text Available The quality of traditional Chinese herbal medicine, which plays a very important role in the health system of China, is determined by the active substances produced by the plants. The type, content, and proportion of these substances may vary depending on ecological factors in areas where the plants are grown. Sinopodophyllum hexandrum (Royle T.S. Ying, an endangered plant species with great medical value, was investigated in eight production locations representative of its natural geographical distribution range in China. The correlation between the contents of the active ingredients extracted from the roots and rhizomes of S. hexandrum and the ecological factors were evaluated step-by-step using a series of computational biology methodologies. The results showed that ecological factors had significant effects on the contents but not on the types of the active ingredients in eight production locations. The primary ecological factors influencing the active substances included the annual average precipitation, July mean temperature, frost-free period, sunshine duration, soil pH, soil organic matter, and rapidly available potassium in the soil. The annual average precipitation was the most important determinant factor and was significantly and negatively correlated with the active ingredient contents (P < 0.001. In contrast, organic matter was the most important limiting factor and was significantly and positively correlated with the active substances. These ecological factors caused 98.13% of the total geographical variation of the active ingredient contents. The climate factors contributed more to the active ingredient contents than did the soil factors. It was concluded that from the view of the contents of the secondary metabolites and ecological factors of each growing location, in Jingyuan, Ningxia Province, and Yongdeng, Gansu Province, conditions were favorable to the production of podophyllotoxin and lignans, whereas in Shangri-La, Yunnan

  16. Self-organising T-S fuzzy Elman network based on EKF%基于EKF的自组织T-S模糊Elman网络

    Institute of Scientific and Technical Information of China (English)

    乔俊飞; 袁喜春; 韩红桂

    2014-01-01

    For the design of the fuzzy neural network architecture and the deficiency of fuzzy sets on semantic description, a self-organising T-S fuzzy Elman network(SOTSFEN) based on extended Kalman filter(EKF) is proposed, and the training algorithm is derived. Furthermore, recursive least square(RLS) and EKF are used to update linear and non-linear parameters respectively. Then the criterion of rule generation is given and error ratio reduction(ERR) is regarded as the fuzzy rule pruning strategy. Finally, the simulation results of system identification and sewage treatment modeling show that the precision and generalization ability of SOTSFEN are ensured, and a simpler architecture network can be achieved simultaneously.%针对模糊神经网络结构设计问题及模糊集在语言描述上存在的不足,提出一种基于扩展的卡尔曼滤波(EKF)的自组织T-S模糊Elman网络,并推导了网络训练算法。分别采用递归最小二乘法和EKF对线性参数和非线性参数进行更新;基于模糊规则生成准则和误差下降率修剪策略实现了模糊规则的增删减。最后通过系统辨识和污水处理建模实验,表明了该算法在保证网络精度和泛化能力的同时,可以有效地简化网络结构。

  17. A Qualitative, Comparative Study of the Use of Electronic Information and Other Services at Universitäts- und Landesbibliothek Münster

    Directory of Open Access Journals (Sweden)

    John C. Crawford

    1999-05-01

    Full Text Available The Universitäts- und Landesbibliothek, (ULB Münster, has a substantial background of research and publication in performance measurement and evaluation of library and information services (Poll and te Boekhorst and has conducted and published internal studies of various aspects of its services.(Obst 1995; Buch 1996. My contact with the Library goes back to late 1996 when I spent two weeks at ULB on a British Council exchange scheme with North Rhine Westphalia which gave me some understanding of how the Library operates and some knowledge of the technical vocabulary of German academic librarianship. In 1998 I directed a qualitative study of the use being made of Glasgow Caledonian University Library’s recently opened Electronic Information Floor (Crawford 1999. A literature review undertaken prior to the study showed that surprisingly little research had been done in this area and that one of the earliest studies was that undertaken by Dr Oliver Obst at Münster (1995. Coincidentally ULB is a partner in the EQUINOX Project, led by CERLIM, which aims to develop a set of standardised performance measures for the electronic library and was interested in collecting some qualitative data as a background to the Project. After email discussions with ULB it was decided that I should visit the Library again to undertake a qualitative study of the use of electronic information services there which would act both as a comparative study with Glasgow Caledonian University and a background study to the much larger, CERLIM led, EQUINOX Project.

  18. Scientific opinion on the safety and efficacy of Natugrain® TS (endo-1,4-beta-xylanase and endo-1,4-beta-glucanase as a feed additive for pigs for fattening

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP

    2013-07-01

    Full Text Available Natugrain® TS is an enzyme preparation that contains endo-1,4-beta-xylanase and endo-1,4-beta-glucanase, produced by two genetically modified strains of Aspergillus niger. This product is currently authorised for use in piglets (weaned, poultry species and ornamental birds as a zootechnical additive under the functional group of digestibility enhancers. The applicant is now seeking for the extension of its use as a zootechnical additive for pigs for fattening at a dose range of 560 to 840 TXU (thermostable xylanase units and 250 to 375 TGU (thermostable glucanase units per kg feed. Since the product has been demonstrated to be  safe in piglets at the maximum recommended dose, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP considers that this conclusion can be extended to pigs for fattening, provided that the same maximum dose applies. In two long-term trials, Natugrain® TS significantly improved the performance of the pigs for fattening at the minimum recommended dose (560 TXU and 250 TGU/kg feed. In a balance trial, the metabolisable energy content of the diet was significantly improved by the addition of Natugrain® TS in feed at the minimum recommended dose. Therefore, the FEEDAP Panel concludes that Natugrain® TS at the minimum recommended dose (560 TXU and 250 TGU/kg feed has the potential to be efficacious in pigs for fattening.

  19. Analýza a zhodnocení plnění požadavků normy ISO/TS 16949 ve společnosti Trafil Czech

    OpenAIRE

    Buzzoni, David

    2015-01-01

    The aim is to analyse the status of the company Trafil Czech with regard to the requirements of ISO/TS 16949: 2009 and propose possible measures designed to achieve compliance with this standard. The thesis is divided into theoretical and practical parts. The first chapter of the theoretical part deals with the definition of quality and its concepts. The second chapter of this work is dedicated to ISO standards and their importance for different segments of society and concepts related to the...

  20. La gestion des coûts de la santé et de la sécurité du travail en entreprise : une recension des écrits

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    Maurice Gosselin

    2005-05-01

    Full Text Available La santé et la sécurité du travail (SST constitue une des problématiques importantes de la gestion des ressources humaines. L’objectif de cet article est de faire une recension de la littérature sur les coûts de la SST et la gestion de ceux-ci. Ce travail permettra de mieux comprendre quels sont les coûts et les avantages de la SST, qui sont les acteurs qui les assument et comment ceux-ci peuvent améliorer la gestion des coûts de la SST.Occupational health and safety (OHS is one of the major issues in human resources management. The objective of this article is to review the literature on OHS costs and their management. This review will provide a better understanding of the costs and benefits of OHS, the parties that assume them, and how they can improve OHS cost management.