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  1. Remembering for tomorrow: Professor Mansour Ali Haseeb.

    Science.gov (United States)

    Salih, Mustafa Abdalla M

    2013-01-01

    This is a highlight of the obituary ceremony in tribute to Professor Mansour Ali Haseeb (1910 - 1973), organized by the Medical Students Association of the Faculty of Medicine, the University of Khartoum (U of K). Professor Haseeb has been the first Sudanese Professor and first Dean of the Faculty of Medicine. He was an outstanding humane teacher, mentor and researcher, and was awarded the international Dr. Shousha Foundation Prize and Medal by the WHO. He was also an active citizen in public life and became Mayor of Omdurman City. The obituary ceremony reflected the feelings of the medical community and included speeches by Professor Abdalla El Tayeb, President of U of K; the Dean, Faculty of Medicine; the Late Professor Haseeb's colleagues and students, His family representative, and an elegy poem.

  2. Lynch Syndrome

    Science.gov (United States)

    ... colon cancer may include surgery, chemotherapy and radiation therapy. Cancer screening for people with Lynch syndrome If you ... et al. Milestones of Lynch syndrome: 1895-2015. Nature Reviews Cancer. http://www.nature.com/nrc/journal/vaop/ncurrent/ ...

  3. David Lynch (Sammelrezension)

    OpenAIRE

    2002-01-01

    Ralfdieter Füller: Fiktion und Antifiktion. Die Filme David Lynchs und der Kulturprozeß im Amerika der 1980er und 90er Jahre.Stefan Höltgen: Spiegelbilder. Strategien der ästhetischen Verdoppelung in den Filmen von David Lynch

  4. Professor Mansour Ali Haseeb: Highlights from a pioneer of biomedical research, physician and scientist

    OpenAIRE

    2013-01-01

    The article highlights the career of Professor Mansour Ali Haseeb (1910 – 1973; DKSM, Dip Bact, FRCPath, FRCP [Lond]), a pioneer worker in health, medical services, biomedical research and medical education in the Sudan. After his graduation from the Kitchener School of Medicine (renamed, Faculty of Medicine, University of Khartoum [U of K]) in 1934, he devoted his life for the development of laboratory medicine. He became the first Sudanese Director of Stack Medical Research Laboratories (19...

  5. Diagnosing Lynch Syndrome

    LENUS (Irish Health Repository)

    Gleeson, J

    2016-11-01

    Lynch Syndrome, also known as Hereditary Non-Polyposis Colorectal Cancer (HNPCC), is a hereditary condition that increases an individual’s risk of developing a constellation of cancers. These most commonly arise in the colon, but also involve other solid organs such as the endometrium and ovaries in women, the stomach, brain and the skin. Ireland’s small population offers an opportunity to identify all those with Lynch Syndrome (LS) in the country, which would represent a powerful preventive opportunity to meaningfully impact on the incidence of cancer in Ireland.

  6. Lynch Syndrome revision.

    Directory of Open Access Journals (Sweden)

    Sila Castellón Mortera

    2013-07-01

    Full Text Available The literature regarding colon`s adenocarcinoma hereditary no poliposico or Lynch Syndrome is reviewed. The clinical characteristics, genetics and histologycal of colon´s adenocarcinoma hereditary, no poliposico are pointed out, so as the updated criteria approved in Amsterdam, for the diagnostic of patients with this Syndrome. The therapeutics is updated.

  7. Unusual presentation of Lynch Syndrome

    Directory of Open Access Journals (Sweden)

    Yu Veronica PCC

    2009-06-01

    Full Text Available Abstract Lynch Syndrome/HNPCC is a syndrome of cancer predisposition linked to inherited mutations of genes participating in post-replicative DNA mismatch repair (MMR. The spectrum of cancer associated with Lynch Syndrome includes tumours of the colorectum, endometrium, ovary, upper gastrointestinal tract and the urothelium although other cancers are rarely described. We describe a family of Lynch Syndrome with an hMLH1 mutation, that harbours an unusual tumour spectrum and its diagnostic and management challenges.

  8. Professor Mansour Ali Haseeb: Highlights from a pioneer of biomedical research, physician and scientist.

    Science.gov (United States)

    Salih, Mustafa Abdalla M

    2013-01-01

    The article highlights the career of Professor Mansour Ali Haseeb (1910 - 1973; DKSM, Dip Bact, FRCPath, FRCP [Lond]), a pioneer worker in health, medical services, biomedical research and medical education in the Sudan. After his graduation from the Kitchener School of Medicine (renamed, Faculty of Medicine, University of Khartoum [U of K]) in 1934, he devoted his life for the development of laboratory medicine. He became the first Sudanese Director of Stack Medical Research Laboratories (1952 - 1962). He made valuable contributions by his services in the vaccine production and implementation programs, most notably in combating small pox, rabies and epidemic meningitis. In 1963 he became the first Sudanese Professor of Microbiology and Parasitology and served as the first Sudanese Dean of the Faculty of Medicine, U of K (1963-1969). He was an active loyal citizen in public life and served in various fields outside the medical profession. As Mayor of Omdurman, he was invited to visit Berlin in 1963 by Willy Brandt, Mayor of West Berlin (1957-1966) and Chancellor of the Federal Republic of Germany (1969 to 1974). Also as Mayor of Omdurman, he represented the City in welcoming Queen Elizabeth II during her visit to Sudan in February 1965. He also received State Medals from Egypt and Ethiopia. In 1973 he was appointed Chairman of the Sudan Medical Research Council, and was awarded the international Dr. Shousha Foundation Prize and Medal by the WHO for his contribution in the advancement of health, research and medical services.

  9. Lynch syndrome-associated neoplasms

    DEFF Research Database (Denmark)

    Shia, Jinru; Holck, Susanne; Depetris, Giovanni;

    2013-01-01

    of interacting developments from the disciplines of clinical oncology, pathology, and molecular genetics, with each development serving to guide or enhance the next. The advancement of our understanding about the pathology of Lynch syndrome associated tumors exemplifies such intimate interplay among disciplines....... Today, accumulative knowledge has enabled surgical pathologists to detect tumors that are likely to be associated with Lynch syndrome, and the pathologist is playing an increasingly more important role in the care of these patients. The pathologist's ability is afforded primarily by information gained...... of such information. This article provides an overview of the development of histopathology and immunohistochemistry in Lynch syndrome-associated tumors, particularly in colorectal and endometrial cancers, and outlines the issues and current status of these specific pathologic aspects in not only the major tumors...

  10. Do Surrealismo em David Lynch

    Directory of Open Access Journals (Sweden)

    Mirian Tavares

    2009-01-01

    Full Text Available O surrealismo, como a arte do seu tempo, propõe uma nova estética, capaz de extrair o belo do absurdo e de instaurar o desvio para que daí surja, de fato, o real. Através da análise de algumas obras de David Lynch e dos livros Les champs magnétiques de Breton e Philippe Soupault e Poisson soluble, de Breton, irei mostrar a pertinência da designação surrealista para a obra do cineasta norte-americano. Lynch, como os surrealistas, constrói uma operação dialética entre o racional/irracional. Ao mesmo tempo em que opera no campo artístico em direção à irracionalidade absoluta, Lynch não nega a sua inserção na sociedade. Acredito que o realizador, como os surrealistas, tenha conseguido encontrar um equilíbrio entre as duas formas de se estar no mundo, racional/irracional, jogando com suas antíteses. O prazer do jogo surrealista consiste em ir até as profundezas do inconsciente e retornar com matéria suficiente para fazer uma obra de arte.Surrealism, as the art of its time, proposes a new aesthetics, one that is able to extract the beautiful from the absurd and to establish the swerve from the standard, from which, in fact, the real comes through. Through the analysis of some works by David Lynch, of Breton and Soupault's Les champs magnétiques, and of Breton's Poisson soluble, I will attempt to show the relevance of the surrealist designation for the work of the American filmmaker. Lynch, like the surrealists, builds a dialectic operation between the rational and the irrational. While operating in the artistic field towards absolute irrationality, Lynch does not deny its role in society. It is my belief that the director, as the surrealists, has managed to find a balance between the two ways of being in the world: rational and irrational; by playing with their antitheses. The pleasure of the surrealist game is to go to the depths of the unconscious and return with sufficient material to make a work of art out of it.

  11. [Founder mutation in Lynch syndrome].

    Science.gov (United States)

    Cajal, Andrea R; Piñero, Tamara A; Verzura, Alicia; Santino, Juan Pablo; Solano, Angela R; Kalfayan, Pablo G; Ferro, Alejandra; Vaccaro, Carlos

    2016-01-01

    Lynch syndrome is the most frequent syndrome in hereditary colorectal cancer, a family-specific deleterious mutations in genes encoding DNA reparation proteins: MLH1 (mutL homolog 1), MSH2, MSH6 (mutS homolog 2 y 6, respectively), PMS2 (PMS1 homolog 2, mismatch repair system component) y MUTYH (mutY DNA glycosylase). The c.2252_2253delAA, p.Lys751Serfs*3 mutation in MLH1 gene segregates with a haplotype reported in the northern region of Italy and whose origin was attributed to a founder effect. This mutation co-segregates with typical characteristics of Lynch syndrome, including early age at onset and multiple primary tumors in the same individual, a high frequency of pancreatic cancer, high microsatellite instability and lack of PMS2 expression. This report describes a mutation in an Argentinian patient with endometrioid adenocarcinoma of uterus. Her first-degree relatives had a history of colon cancer diagnosed before 50 years, fulfilling the Amsterdam Criteria I and Lynch syndrome II. The high pathogenicity associated to this mutation makes necessary the study of all members from families with hereditary cancer, allowing pre-symptomatic genetic diagnosis, early assessment and the instauration of preventive treatments.

  12. Modernization and Lynching in the New South

    Directory of Open Access Journals (Sweden)

    Mattias Smångs

    2016-09-01

    Full Text Available This article evaluates an emerging body of historical scholarship that challenges prevailing views of the primacy of rural conditions in southern lynching by positing that it was symbiotically associated with the processes of modernization underway in the region in the decades around 1900. Statistical analyses of lynching data that differentiate among events according to communal participation, support, and ceremony in Georgia and Louisiana from 1882 to 1930 and local-level indices of modernization (urbanization, rural depopulation, industrialization, agricultural commercialization, and dissolution of traditional family roles yield results that both support and contradict such a modernization thesis of lynching. The findings imply that the consequences of the social transformation in the South coinciding with the lynching era were not uniform throughout the region with regard to racial conflict and violence and that broad arguments proposing an intrinsic connection between modernization and lynchings therefore are overstated.

  13. Lynch syndrome: still not a familiar picture

    Directory of Open Access Journals (Sweden)

    Hes Frederik J

    2008-02-01

    Full Text Available Abstract Background Germ line mutations in mismatch repair genes underlie Lynch syndrome and predispose carriers for colorectal carcinoma and malignancies in many other organ systems. Case presentation A large Lynch syndrome family with 15 affected family members and involvement in 7 organs is reported. It illustrates a lack of awareness and knowledge about this hereditary tumor syndrome among doctors as well as patients. None of the described family members underwent presymptomatic screening on the basis of the family history. Conclusion Hereditary features, like young age at diagnosis, multiple tumors in multiple organs and a positive family history, should lead to timely referral of suspected cases for genetic counseling and diagnostics. For Lynch syndrome, these features can be found in the Amsterdam and Bethesda criteria. Subsequently, early identification of mutation carriers might have diminished, at least in part, the high and early morbidity and mortality observed in this family.

  14. The Lynch syndrome: a management dilemma.

    Science.gov (United States)

    Palumbo, Piergaspare; Amatucci, Chiara; Perotti, Bruno; Dezzi, Claudia; Girolami, Marco; Illuminati, Giulio; Angelici, Alberto M

    2013-05-01

    The case of a familial Lynch syndrome is reported. The criteria for early diagnosis, management and surveillance are briefly reviewed. A germline mutation of genes responsible for mismatch repair is at the basis of the Lynch syndrome. Carriers are predisposed to colorectal cancer and other tumors. Two members of the presently reported family developed colorectal cancer, whereas two others developed other neoplasms. The syndrome was confirmed in members of the same family with appropriate genetic workup. Clinical examination and endoscopy were consequently scheduled once-a-year. Given the high risk of neoplastic disease, such yearly controls can be proposed as the standard follow-up of this condition.

  15. Role for Genetic Anticipation in Lynch Syndrome

    DEFF Research Database (Denmark)

    Nilbert, Mef; Timshel, Susanne; Bernstein, Inge

    2009-01-01

    PURPOSE: Anticipation (ie, an earlier age at onset in successive generations) is linked to repeat expansion in neurodegenerative syndromes, whereas its role in hereditary cancer is unclear. We assessed anticipation in Lynch syndrome (hereditary nonpolyposis colorectal cancer [HNPCC]), in which DN...

  16. Merrill Lynch kavandab äridelegatsiooni visiiti Eestisse

    Index Scriptorium Estoniae

    2000-01-01

    Investeerimispanga Merrill Lynch eestvedamisel kavandatakse mais ärimeeste visiiti Eestisse, ütles Jüri Mõis, kes viibis New Yorgis toimunud Maailmapanga seminaril "Omavalitsused rahvusvahelistel kapitaliturgudel"

  17. Mutation spectrum in South American Lynch syndrome families

    DEFF Research Database (Denmark)

    Dominguez-Valentin, Mev; Nilbert, Mef; Wernhoff, Patrik;

    2013-01-01

    Genetic counselling and testing for Lynch syndrome have recently been introduced in several South American countries, though yet not available in the public health care system.......Genetic counselling and testing for Lynch syndrome have recently been introduced in several South American countries, though yet not available in the public health care system....

  18. Recurrence and Variability of Germline EPCAM Deletions in Lynch Syndrome

    NARCIS (Netherlands)

    Kuiper, Roland P.; Vissers, Lisenka E. L. M.; Venkatachalam, Ramprasath; Bodmer, Danielle; Hoenselaar, Eveline; Goossens, Monique; Haufe, Aline; Kamping, Eveline; Niessen, Renee C.; Hogervorst, Frans B. L.; Gille, Johan J. P.; Redeker, Bert; Tops, Carli M. J.; van Gijn, Marielle E.; van den Ouweland, Ans M. W.; Rahner, Nils; Steinke, Verena; Kahl, Philip; Holinski-Feder, Elke; Morak, Monika; Kloor, Matthias; Stemmler, Susanne; Betz, Beate; Hutter, Pierre; Bunyan, David J.; Syngal, Sapna; Culver, Julie O.; Graham, Tracy; Chan, Tsun L.; Nagtegaal, Iris D.; van Krieken, J. Han J. M.; Schackert, Hans K.; Hoogerbrugge, Nicoline; van Kessel, Ad Geurts; Ligtenberg, Marjolijn J. L.

    2011-01-01

    Recently, we identified 3' end deletions in the EPCAM gene as a novel cause of Lynch syndrome. These truncating EPCAM deletions cause allele-specific epigenetic silencing of the neighboring DNA mismatch repair gene MSH2 in tissues expressing EPCAM. Here we screened a cohort of unexplained Lynch-like

  19. Management of extracolonic tumours in patients with Lynch syndrome

    NARCIS (Netherlands)

    Koornstra, Jan J; Mourits, Marian Je; Sijmons, Rolf H; Leliveld-Kors, Anna; Hollema, Harry; Kleibeuker, Jan H

    2009-01-01

    Hereditary nonpolyposis colorectal cancer, or Lynch syndrome, is responsible for 2-3% of all colorectal cancers. Lynch syndrome is also associated with a high risk of extracolonic cancers, including endometrial, stomach, small bowel, pancreas, biliary tract, ovary, urinary tract, brain, and skin can

  20. Role for Genetic Anticipation in Lynch Syndrome

    DEFF Research Database (Denmark)

    Nilbert, Mef; Timshel, Susanne; Bernstein, Inge

    2009-01-01

    parent-child pairs in which age at the first cancer diagnosis was assessed. A paired t-test and a specifically developed bivariate model were used to assess a possible role of anticipation. RESULTS: Both methods revealed anticipation with children developing cancer mean 9.8 years (P ... parents using the paired t-test and 5.5 years (P ... to initiate surveillance programs at young age. It should also stimulate research into the genetic mechanisms that determine age at onset and whether the genetic instability that characterizes Lynch syndrome can be linked to anticipation....

  1. Glioblastomas, astrocytomas and oligodendrogliomas linked to Lynch syndrome

    DEFF Research Database (Denmark)

    Therkildsen, C; Ladelund, S; Rambech, E

    2015-01-01

    BACKGROUND AND PURPOSE: Brain tumors represent a rare and relatively uncharacterized tumor type in Lynch syndrome. METHODS: The national Danish Hereditary Nonpolyposis Colorectal Cancer Register was utilized to estimate the cumulative life-time risk for brain tumors in Lynch syndrome...... staining suggestive of the IDH1 R132H mutation. CONCLUSION: In Lynch syndrome brain tumors occurred in 14% of the families with significantly higher risks for individuals with MSH2 gene mutations and development of childhood brain tumors in individuals with constitutional MMR defects....

  2. The Identification of Lynch Syndrome in British Columbia

    Directory of Open Access Journals (Sweden)

    Carol M Cremin

    2009-01-01

    Full Text Available OBJECTIVE: To determine the prevalence of Lynch syndrome mutations in a Canadian hereditary cancer clinic population, and to determine the effectiveness of the program’s referral criteria and testing algorithm.

  3. Pupazzi di neve. David Lynch fotografo e l’"Unheimliche"

    Directory of Open Access Journals (Sweden)

    Paolo Sebastiano Lanzi

    2013-02-01

    Full Text Available L’opera di David Lynch non si limita al cinema, come ha dimostrato l’esposizione del 2007 alla Fondation Cartier di Parigi, The Air is on Fire. Tuttavia gli studi teorici hanno trascurato ciò che gallerie e musei hanno evidenziato da tempo: il Lynch pittore, fotografo, musicista, artista poliedrico. L’articolo si focalizza su una serie fotografica, Snowmen, ed è tratto da una ricerca di Paolo Sebastiano Lanzi sulla figura di David Lynch fotografo. Alla luce del saggio di Freud sul Perturbante (Das Unheimliche, 1919 si interpretano gli Snowmen come immagini di morte. Si chiariscono alcuni aspetti della poetica dell’artista-regista, come l’inquietudine dell’Inland Empire o di certe idee care al Surrealismo. Lo studio della produzione fotografica di Lynch riempie un vuoto nell’analisi critica sul suo lavoro, che va necessariamente riconsiderato in una prospettiva più ampia.

  4. Quality of colonoscopy in Lynch syndrome.

    Science.gov (United States)

    Niv, Yaron; Moeslein, Gabriela; Vasen, Hans F A; Karner-Hanusch, Judith; Lubinsky, Jan; Gasche, Christoph

    2014-12-01

    Lynch syndrome (LS) accounts for 2 - 4 % of all colorectal cancers. Affected family members have a germline mutation in one of the DNA mismatch repair genes MLH1, PMS2, MSH2, or MSH6, and a lifetime risk for development of colorectal cancer of 25 - 75 %. Current guidelines recommend annual to biannual surveillance colonoscopy in mutation carriers. Several factors may predict failure to prevent interval cancer in LS: more lesions in the right colon; more flat ("non polypoid") and lateral growing polyps; small adenomas may already harbor high grade dysplasia or a high percentage of villous component and become advanced adenomas; there is a short duration of the adenoma - carcinoma sequence; synchronous lesions have high prevalence; patients are younger and less tolerant to colonoscopy (need more sedation); and repeated colonoscopies are needed for lifelong surveillance (patient experience is important for compliance). In order to prevent cancer in LS patients, surveillance colonoscopy should be performed in an endoscopic unit experienced with LS, every 1 - 2 years, starting at age 20 - 25 years, or 10 years younger than the age of first diagnosis in the family (whichever is first), and yearly after the age of 40 years. Colonoscopy in LS patients should be a very meticulous and precise procedure (i. e. taking sufficient withdrawal time, documentation of such warranted), with removal of all of the polyps, special attention to the right colon and alertness to flat lesions. Following quality indicators such as successful cleansing of the colon and removal of every polyp will probably improve prevention of interval cancers. At this moment, none of the new endoscopic techniques have shown convincing superiority over conventional high resolution white light colonoscopy.

  5. Surveillance for urinary tract cancer in Lynch syndrome

    DEFF Research Database (Denmark)

    Bernstein, Inge Thomsen; Myrhøj, Torben

    2013-01-01

    Hereditary non-polyposis colorectal cancer (HNPCC) is an inherited multiorgan cancer syndrome, which when caused by a germline mutation in the mismatch repair (MMR) genes is known as Lynch syndrome (LS). Mutation carriers are at risk for developing cancers primarily in the colon, rectum and endom...

  6. Decrease in mortality in Lynch syndrome families because of surveillance.

    NARCIS (Netherlands)

    Jong, A.E. de; Hendriks, Y.M.; Kleibeuker, J.H.; Boer, S.Y. de; Cats, A.; Griffioen, G.; Nagengast, F.M.; Nelis, F.G.; Rookus, M.A.; Vasen, H.F.

    2006-01-01

    BACKGROUND & AIMS: Lynch syndrome family members have a high risk of developing colorectal (CRC), endometrial (EC), and other cancers. A large-scale surveillance program was introduced in The Netherlands in the late 1980s. The aims of the study were to evaluate the effectiveness of this program by a

  7. Role of new endoscopic techniques in Lynch syndrome

    NARCIS (Netherlands)

    Haanstra, Jasmijn F.; Kleibeuker, Jan H.; Koornstra, Jan J.

    2013-01-01

    Lynch syndrome, or hereditary nonpolyposis colorectal cancer (HNPCC), is the most common hereditary condition predisposing for colorectal cancer. International guidelines recommend surveillance of the colorectum by colonoscopy every 1-2 years starting at the age of 20-25 years. This has been shown t

  8. Sense of coherence and self-concept in Lynch syndrome

    DEFF Research Database (Denmark)

    Petersen, Helle Vendel; Ladelund, Steen; Carlsson, Christina

    2013-01-01

    Most individuals who learn about hereditary cancer manage well, but identification of subgroups who find this knowledge burdening would allow psychosocial intervention. The objective of the study was to assess sense of coherence (SOC) in individuals with Lynch syndrome with comparison to a genera...... population and correlation to self-concept....

  9. Genetic testing for Lynch syndrome: family communication and motivation

    NARCIS (Netherlands)

    C.H.M. Leenen (Celine); M.D. Heijer (Mariska den); C.A. van der Meer (Conny); E.J. Kuipers (Ernst); M.E. van Leerdam (Monique); A. Wagner (Anja)

    2016-01-01

    textabstractCurrent genetic counselling practice for Lynch syndrome (LS) relies on diagnosed index patients to inform their biological family about LS, referred to as the family-mediated approach. The objective of this study was to evaluate this approach and to identify factors influencing the uptak

  10. Risks of lynch syndrome cancers for msh6 mutation carriers

    NARCIS (Netherlands)

    L. Baglietto (Laura); N.M. Lindor (Noralane); J.G. Dowty (James); D.M. White (Darren); A. Wagner (Anja); E.B. Gómez García (Encarna); A.H.J.T. Vriends (Anette); N.R. Cartwright (Nicola); R.A. Barnetson (Rebecca); S.M. Farrington (Susan); A. Tenesa (Albert); H. Hampel (Heather); D. Buchanan (Daniel); S. Arnold (Sven); J. Young (Joanne); M.D. Walsh (Michael); J. Jass (Jeremy); F.A. Macrae (Finlay); Y. Antill (Yoland); I.M. Winship (Ingrid); G.G. Giles (Graham); J. Goldblatt (Jack); S. Parry (Susan); G. Suthers (Graeme); B. Leggett (Barbara); M. Butz (Malinda); M. Aronson (Melyssa); J.N. Poynter (Jenny); J.A. Baron (John); L. Le Marchand (Loic); R. Haile (Robert); S. Gallinger (Steve); J.L. Hopper (John); J. Potter (John); A. de La Chapelle (Albert); H. Vasen (Hans); M.G. Dunlop (Malcolm); S.N. Thibodeau (Stephen); M.A. Jenkins (Mark)

    2010-01-01

    textabstractBackground: Germline mutations in MSH6 account for 10%-20% of Lynch syndrome colorectal cancers caused by hereditary DNA mismatch repair gene mutations. Because there have been only a few studies of mutation carriers, their cancer risks are uncertain. Methods: We identified 113 families

  11. Lynch Syndrome Caused by Germline PMS2 Mutations

    DEFF Research Database (Denmark)

    Ten Broeke, Sanne W; Brohet, Richard M; Tops, Carli M

    2015-01-01

    . Standardized incidence ratios (SIRs) were calculated to estimate risks for other Lynch syndrome-associated cancers. RESULTS: The cumulative risk (CR) of CRC for male mutation carriers by age 70 years was 19%. The CR among female carriers was 11% for CRC and 12% for EC. The mean age of CRC development was 52......PURPOSE: The clinical consequences of PMS2 germline mutations are poorly understood compared with other Lynch-associated mismatch repair gene (MMR) mutations. The aim of this European cohort study was to define the cancer risk faced by PMS2 mutation carriers. METHODS: Data were collected from 98...... years, and there was a significant difference in mean age of CRC between the probands (mean, 47 years; range, 26 to 68 years) and other family members with a PMS2 mutation (mean, 58 years; range, 31 to 86 years; P

  12. Ssk or Esw? -- the Bloor-Lynch Debate Revisited

    Science.gov (United States)

    Cheng, Kai-Yuan

    2014-03-01

    Philosophical discussions of rule-following in the later Wittgenstein (1953, 1967) are an important source of inspiration for the development of views on the social nature of scientific knowledge. Two major opposing views in this inquiry -- Bloor's sociology of scientific knowledge (SSK) (1983, 1991, 1992, 1997) and Lynch's (1992, 1993) ethnomethodological studies of work (ESW) -- represent two positions derived from two different readings of Wittgenstein's later writings on rule-following. The aim of this paper is two-fold. One is to re-examine the noted Bloor-Lynch debate by considering Kusch's (2004) recent discussion of this debate. Another is to show that a new semantic framework of rule-following ascriptions based on a cognitive approach to the study of generics can be provided such that SSK and ESW are compatible in it (Leslie, 2009; Cheng, 2011).

  13. Surveillance colonoscopy practice in Lynch syndrome in the Netherlands: A nationwide survey

    Institute of Scientific and Technical Information of China (English)

    Jan J Koornstra; Hans FA Vasen

    2007-01-01

    Lynch syndrome, or hereditary nonpolyposis colorectal cancer (HNPCC), is the most common genetic disorder predisposing to colorectal cancer. As regular colonoscopic surveillance has been shown to reduce the incidence of colorectal cancer, this strategy is recommended worldwide. Recently, several advances in colonoscopic techniques have improved detection rates of neoplasia in Lynch syndrome. In this nationwide survey, we evaluated current surveillance colonoscopy practices for Lynch syndrome in the Netherlands and the extent to which advanced techniques have been adopted in routine clinical practice.

  14. Fertility and apparent genetic anticipation in Lynch syndrome.

    Science.gov (United States)

    Stupart, Douglas; Win, Aung Ko; Jenkins, Mark; Winship, Ingrid M; Goldberg, Paul; Ramesar, Rajkumar

    2014-09-01

    Genetic anticipation is the phenomenon in which age of onset of an inherited disorder decreases in successive generations. Inconsistent evidence suggests that this occurs in Lynch syndrome. A possible cause for apparent anticipation is fecundity bias, which occurs if the disease adversely affects fertility. The purpose of this study was to determine the effect of age of diagnosis of colorectal cancer (CRC) on lifetime fertility in Lynch syndrome, and whether this can falsely create the appearance of genetic anticipation. A computer model simulated age of diagnosis of CRC in hypothetical Lynch syndrome carriers and their offspring. The model assumed similar age distribution of CRC across generations (i.e. that there was no true anticipation). Age distribution of CRC diagnosis, and lifetime fertility rates (grouped by age of diagnosis of CRC) were determined from the Australasian Colorectal Cancer Family Registry (ACCFR). Apparent anticipation was calculated by comparing ages of diagnosis of CRC in affected parent-child pairs. A total of 1,088 patients with CRC were identified from the ACCFR. Total lifetime (cohort) fertility was related to age of diagnosis of CRC (correlation coefficient 0.13, P = 0.0001). In the simulation, apparent anticipation was 1.8 ± 0.54 years (P = 0.0044). Observed apparent anticipation in the ACCFR cohort was 4.8 ± 1.73 years (P = 0.0064). There was no difference in apparent anticipation between the simulate d and observed parent-child pairs (P = 0.89). The appearance of genetic anticipation in Lynch syndrome can be falsely created due to changes in fertility.

  15. The mutational spectrum of Lynch syndrome in cyprus.

    Science.gov (United States)

    Loizidou, Maria A; Neophytou, Ioanna; Papamichael, Demetris; Kountourakis, Panteleimon; Vassiliou, Vassilios; Marcou, Yiola; Kakouri, Eleni; Ioannidis, Georgios; Philippou, Chrystalla; Spanou, Elena; Tanteles, George A; Anastasiadou, Violetta; Hadjisavvas, Andreas; Kyriacou, Kyriacos

    2014-01-01

    Lynch syndrome is the most common form of hereditary colorectal cancer and is caused by germline mutations in the mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2. Mutation carriers have an increased lifetime risk of developing colorectal cancer as well as other extracolonic tumours. The aim of the current study was to evaluate the frequency and distribution of mutations in the MLH1, MSH2 and MSH6 genes within a cohort of Cypriot families that fulfilled the revised Bethesda guidelines. The study cohort included 77 patients who fulfilled at least one of the revised Bethesda guidelines. Mutational analysis revealed the presence of 4 pathogenic mutations, 3 in the MLH1 gene and 1 in the MSH2 gene, in 5 unrelated individuals. It is noted that out of the 4 pathogenic mutations detected, one is novel (c.1610delG in exon 14 of the MLH1) and has been detected for the first time in the Cypriot population. Overall, the pathogenic mutation detection rate in our patient cohort was 7%. This percentage is relatively low but could be explained by the fact that the sole criterion for genetic screening was compliance to the revised Bethesda guidelines. Larger numbers of Lynch syndrome families and screening of the two additional predisposition genes, PMS2 and EPCAM, are needed in order to decipher the full spectrum of mutations associated with Lynch syndrome predisposition in Cyprus.

  16. Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients

    Directory of Open Access Journals (Sweden)

    Kristen M. Drescher

    2010-01-01

    Full Text Available High levels of microsatellite instability (MSI-high are a cardinal feature of colorectal tumors from patients with Lynch Syndrome. Other key characteristics of Lynch Syndrome are that these patients experience fewer metastases and have enhanced survival when compared to patients diagnosed with microsatellite stable (MSS colorectal cancer. Many of the characteristics associated with Lynch Syndrome including enhanced survival are also observed in patients with sporadic MSI-high colorectal cancer. In this review we will present the current state of knowledge regarding the mechanisms that are utilized by the host to control colorectal cancer in Lynch Syndrome and why these same mechanisms fail in MSS colorectal cancers.

  17. The genetic basis of Lynch syndrome and its implications for clinical practice and risk management.

    Science.gov (United States)

    Cohen, Stephanie A; Leininger, Anna

    2014-01-01

    Lynch syndrome is the most common cause of hereditary colon cancer, and accounts for as much as 3% of all colon and endometrial cancers. The identification and management of individuals with Lynch syndrome have evolved over the past 20 years, yet the syndrome remains vastly underdiagnosed. It is important for clinicians to recognize individuals and families who are at risk in order to be able to manage them appropriately and reduce their morbidity and mortality from this condition. This review will touch on the history of Lynch syndrome, the current knowledge of genotype-phenotype correlations, the cancers associated with Lynch syndrome, and management of individuals who are gene carriers.

  18. The Caring Business: Lynch Community Homes, Willow Grove, Pennsylvania. A Case Study.

    Science.gov (United States)

    Bogdan, Robert

    This paper, one of a series of reports describing innovative practices in integrating people with disabilities into community life, describes the Lynch Community Homes in Willow Grove, Pennsylvania. Lynch Homes is a for-profit organization that provides homes and supportive services for approximately 75 people with severe and profound…

  19. Advancing Scholarship and Intellectual Productivity: An Interview with Clifford A. Lynch

    Science.gov (United States)

    Hawkins, Brian L.

    2006-01-01

    In this second part of a two-part interview with Clifford A. Lynch, Executive Director of the Coalition for Networked Information, Lynch talks to Hawkins about the most provocative and exciting projects that are being developed in the field of networked information worldwide. He also talks on how institutional repositories are being currently…

  20. The genetic basis of Lynch syndrome and its implications for clinical practice and risk management

    Directory of Open Access Journals (Sweden)

    Cohen SA

    2014-07-01

    Full Text Available Stephanie A Cohen,1 Anna Leininger2 1Cancer Genetics Risk Assessment Program, St Vincent Health, Indianapolis, IN, USA; 2Minnesota Oncology, Woodbury, MN, USA Abstract: Lynch syndrome is the most common cause of hereditary colon cancer, and accounts for as much as 3% of all colon and endometrial cancers. The identification and management of individuals with Lynch syndrome have evolved over the past 20 years, yet the syndrome remains vastly underdiagnosed. It is important for clinicians to recognize individuals and families who are at risk in order to be able to manage them appropriately and reduce their morbidity and mortality from this condition. This review will touch on the history of Lynch syndrome, the current knowledge of genotype–phenotype correlations, the cancers associated with Lynch syndrome, and management of individuals who are gene carriers. Keywords: Lynch syndrome, hereditary cancer, hereditary nonpolyposis colorectal cancer, mismatch repair, mismatch repair genes, immunohistochemistry, microsatellite instability

  1. Novel Implications in Molecular Diagnosis of Lynch Syndrome

    Directory of Open Access Journals (Sweden)

    Raffaella Liccardo

    2017-01-01

    Full Text Available About 10% of total colorectal cancers are associated with known Mendelian inheritance, as Familial Adenomatous Polyposis (FAP and Lynch syndrome (LS. In these cancer types the clinical manifestations of disease are due to mutations in high-risk alleles, with a penetrance at least of 70%. The LS is associated with germline mutations in the DNA mismatch repair (MMR genes. However, the mutation detection analysis of these genes does not always provide informative results for genetic counseling of LS patients. Very often, the molecular analysis reveals the presence of variants of unknown significance (VUSs whose interpretation is not easy and requires the combination of different analytical strategies to get a proper assessment of their pathogenicity. In some cases, these VUSs may make a more substantial overall contribution to cancer risk than the well-assessed severe Mendelian variants. Moreover, it could also be possible that the simultaneous presence of these genetic variants in several MMR genes that behave as low risk alleles might contribute in a cooperative manner to increase the risk of hereditary cancer. In this paper, through a review of the recent literature, we have speculated a novel inheritance model in the Lynch syndrome; this could pave the way toward new diagnostic perspectives.

  2. “Silencio”: hearing loss in David Lynch's Mulholland Drive

    Directory of Open Access Journals (Sweden)

    Allister Mactaggart

    2014-11-01

    Full Text Available In a filmmaking career replete with extraordinary images and sounds, David Lynch's Mulholland Drive (2001 stands out for attention as a striking and seemingly inexhaustible resource for analysis. In this article, this film is used to examine the specific ways in which Lynch uses pre-existing pop songs to wrap the spectator within the filmic soundscape. Nowhere is the complexity and uncanniness of pop music made more explicit than in Rebekah Del Rio's stunning performance of “Llorando (Crying” in the Club Silencio scene. The split between the singer's powerful performance and her subsequent collapse with the sound of the voice left hanging in the air marks a pivotal point in the film. This scene, coupled with other examples of feminine jouissance, is contrasted with the deadening roar of the master's voice, which solely demands obedience but is deaf to any reply. At the core of this article is an analysis of the status of the voice (and the gaze as examples of the Lacanian object a and its relationship to Marx's concept of surplus value. Mulholland Drive provides a powerful demonstration of how these concepts can be seen, heard, and felt in relation to film, and how sound can reverberate into the spaces and silences beyond the screen.

  3. Prevalence of Lynch syndrome and Lynch-like syndrome among patients with colorectal cancer in a Japanese hospital-based population.

    Science.gov (United States)

    Chika, Noriyasu; Eguchi, Hidetaka; Kumamoto, Kensuke; Suzuki, Okihide; Ishibashi, Keiichiro; Tachikawa, Tetsuhiko; Akagi, Kiwamu; Tamaru, Jun-Ichi; Okazaki, Yasushi; Ishida, Hideyuki

    2017-02-09

    We investigated the prevalence of Lynch syndrome and Lynch-like syndrome among Japanese colorectal cancer patients, as there have been no credible data from Japan. Immunohistochemical analyses for mismatch repair proteins (MLH1, MSH2, MSH6 and PMS2) were carried out in surgically resected, formalin-fixed paraffin-embedded specimens obtained from 1,234 newly diagnosed colorectal cancer patients between March 2005 and April 2014. The presence/absence of the BRAF V600E mutation and hypermethylation of the MLH1 promoter was analyzed where necessary. Genetic testing was finally undertaken in patients suspected as having Lynch syndrome. By the universal screening approach with immunohistochemical analysis for mismatch repair proteins followed by analyses for the BRAF V600E mutation and MLH1 promoter methylation status, 11 (0.9%) of the 1,234 patients were identified as candidates for genetic testing. Out of the 11 patients, 9 (0.7%) were finally diagnosed as having Lynch syndrome; the responsible genes included MLH1 (n = 1), MSH2 (n = 4), EPCAM (n = 1) and MSH6 (n = 3). The remaining two patients (0.2%) were regarded as having Lynch-like syndrome, since biallelic somatic deletion of the relevant mismatch repair genes was detected in the absence of germline mismatch repair alterations. None of the cases was identified as having germline MLH1 epimutation. The prevalence of Lynch syndrome among all newly diagnosed cases of colorectal cancer in Japan is in the same range as that recently reported by studies in Western population. The prevalence of Lynch-like syndrome seems to be extremely low.

  4. Distinct gene expression profiles in ovarian cancer linked to Lynch syndrome

    DEFF Research Database (Denmark)

    Jönsson, Jenny-Maria; Bartuma, Katarina; Dominguez-Valentin, Mev

    2014-01-01

    Ovarian cancer linked to Lynch syndrome represents a rare subset that typically presents at young age as early-stage tumors with an overrepresentation of endometrioid and clear cell histologies. We investigated the molecular profiles of Lynch syndrome-associated and sporadic ovarian cancer...... ovarian cancers. Lynch syndrome-associated and sporadic ovarian cancers differed by 349 significantly deregulated genes, including PTPRH, BIRC3, SHH and TNFRSF6B. The genes involved were predominantly linked to cell growth, proliferation, and cell-to-cell signaling and interaction. When stratified...... for histologic subtype, hierarchical clustering confirmed distinct differences related to heredity in the endometrioid and serous subtypes. Furthermore, separate clustering was achieved in an independent, publically available data set. The distinct genetic signatures in Lynch syndrome-associated and sporadic...

  5. Media lynching in Romanian mass media and politics. Definition and short explanations

    OpenAIRE

    Ion Novăcescu

    2013-01-01

    The Monitoring Report of justice in Romania, published by the European Commission in late January of this year, has sparked an intense controversy in Romanian politics between the president of Romania and the prime minister of the country, which has focused on the mediatic lynching who was practiced against the judges and the anti-corruption prosecutors. This article defines and analyzes the mediatic lynching and its specific features that distinguish it from a press campaign.

  6. Media lynching in Romanian mass media and politics. Definition and short explanations

    Directory of Open Access Journals (Sweden)

    Ion Novăcescu

    2013-04-01

    Full Text Available The Monitoring Report of justice in Romania, published by the European Commission in late January of this year, has sparked an intense controversy in Romanian politics between the president of Romania and the prime minister of the country, which has focused on the mediatic lynching who was practiced against the judges and the anti-corruption prosecutors. This article defines and analyzes the mediatic lynching and its specific features that distinguish it from a press campaign.

  7. Risk of Cancer in Cases of Suspected Lynch Syndrome Without Germline Mutation

    OpenAIRE

    Rodríguez-Soler, María; Pérez-Carbonell, Lucía; Guarinos, Carla; Zapater, Pedro; Castillejo, Adela; Barberá, Víctor Manuel; Juárez, Miriam; Bessa, Xavier; Xicola, Rosa M; Clofent, Juan; Bujanda, Luis; Balaguer, Francesc; Reñé, Josep-Maria; de Castro, Luisa; Marín-Gabriel, José C.

    2013-01-01

    Background & Aims: Colorectal cancers (CRCs) with microsatellite instability (MSI) and a mismatch repair (MMR) immunohistochemical deficit without hypermethylation of the MLH1 promoter are likely to be caused by Lynch syndrome. Some patients with these cancers have not been found to have pathogenic germline mutations and are considered to have Lynch-like syndrome (LLS). The aim of this study was to determine the risk of cancer in families of patients with LLS. Methods: We studied a population...

  8. Distinct Gene Expression Signatures in Lynch Syndrome and Familial Colorectal Cancer Type X

    DEFF Research Database (Denmark)

    Valentin, Mev; Therkildsen, Christina; Veerla, Srinivas;

    2013-01-01

    Heredity is estimated to cause at least 20% of colorectal cancer. The hereditary nonpolyposis colorectal cancer subset is divided into Lynch syndrome and familial colorectal cancer type X (FCCTX) based on presence of mismatch repair (MMR) gene defects.......Heredity is estimated to cause at least 20% of colorectal cancer. The hereditary nonpolyposis colorectal cancer subset is divided into Lynch syndrome and familial colorectal cancer type X (FCCTX) based on presence of mismatch repair (MMR) gene defects....

  9. Papillary thyroid carcinoma (PTC) in Lynch syndrome: Report of two cases and discussion on Lynch syndrome behaviour and genetics.

    Science.gov (United States)

    Pelizzo, M R; Pennelli, G; Zane, M; Galuppini, F; Colletti, P M; Merante Boschin, I; Rubello, D

    2015-08-01

    We present here two cases of papillary thyroid carcinoma (PTC) in patients affected by Lynch syndrome (LS). The first case is a 47-year-old woman with typical hereditary non-polyposis colorectal cancer (HNPCC) syndrome, reported with endometrial and ovarian carcinoma at age 43, and colon cancer at age 45. The patient underwent total thyroidectomy and central node dissection in 2007, at 47years old, with a histological diagnosis of PTC (T1aN1a). Molecular genetics showed a germ-line mutation of the MLH1 gene, 1858 G>T(E620X), with substitution of glycine with a stop codon at position 620. This mutation has pathogenetic significance and was considered responsible for the various tumours of the HNPCC spectrum. In particular, in the same kindred, spanning 5 generations, there were 5 members with colorectal cancer, 4 with endometrial cancer, 3 with gastric and 2 with breast cancer. The second case is a 34-year-old man with typical HNPCC syndrome with colonic resection for colon cancer at age 21. The patient underwent total thyroidectomy with central and lateral node dissection in 2010, at age 34, with a histological diagnosis of PTC with nodal metastases (pT4N1b). Molecular genetic analysis showed a germ-line mutation of the MSH2 gene (thymine insertion at position 907). This mutation had pathogenetic significance and was considered responsible for HNPCC development. Two similar cases have been reported: a 39-year-old woman, and a 44-year-old woman, affected by HNPCC syndrome, with anaplastic thyroid carcinoma and undifferentiated thyroid carcinoma, respectively. We reviewed the Lynch syndrome literature on the history, genetics and expanding tumour spectrum of this condition. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  10. Genetic testing for Lynch syndrome: family communication and motivation.

    Science.gov (United States)

    Leenen, Celine H M; Heijer, Mariska den; van der Meer, Conny; Kuipers, Ernst J; van Leerdam, Monique E; Wagner, Anja

    2016-01-01

    Current genetic counselling practice for Lynch syndrome (LS) relies on diagnosed index patients to inform their biological family about LS, referred to as the family-mediated approach. The objective of this study was to evaluate this approach and to identify factors influencing the uptake of genetic testing for LS. In 59 mutation carriers, 70 non carriers and 16 non-tested relatives socio-demographic characteristics, family communication regarding LS, experiences and attitudes towards the family-mediated approach and motivations for genetic testing, were assessed. The majority of all respondents (73 %) were satisfied with the family-mediated approach. Nevertheless, 59 % of the respondents experienced informing a family member and 57 % being informed by a family member as burdensome. Non-tested differed from tested respondents, in that they were younger, less closely related to the index patient and a lower proportion had children. The most important reasons for declining genetic testing were (1) anticipating problems with life insurance and mortgage, (2) being content with life as it is, and (3) not experiencing any physical complaints. In conclusion, the majority of respondents consider the current family-mediated information procedure acceptable, although the provision of information on LS by relatives may be burdensome. Special attention should be paid to communication of LS to more distant relatives.

  11. How does genetic risk information for Lynch syndrome translate to risk management behaviours?

    Science.gov (United States)

    Steel, Emma; Robbins, Andrew; Jenkins, Mark; Flander, Louisa; Gaff, Clara; Keogh, Louise

    2017-01-01

    There is limited research on why some individuals who have undergone predictive genetic testing for Lynch syndrome do not adhere to screening recommendations. This study aimed to explore qualitatively how Lynch syndrome non-carriers and carriers translate genetic risk information and advice to decisions about risk managment behaviours in the Australian healthcare system. Participants of the Australasian Colorectal Cancer Family Registry who had undergone predictive genetic testing for Lynch syndrome were interviewed on their risk management behaviours. Transcripts were analysed thematically using a comparative coding analysis. Thirty-three people were interviewed. Of the non-carriers (n = 16), 2 reported having apparently unnecessary colonoscopies, and 6 were unsure about what population-based colorectal cancer screening entails. Of the carriers (n = 17), 2 reported they had not had regular colonoscopies, and spoke about their discomfort with the screening process and a lack of faith in the procedure's ability to reduce their risk of developing colorectal cancer. Of the female carriers (n = 9), 2 could not recall being informed about the associated risk of gynaecological cancers. Non-carriers and female carriers of Lynch syndrome could benefit from further clarity and advice about appropriate risk management options. For those carriers who did not adhere to colonoscopy screening, a lack of faith in both genetic test results and screening were evident. It is essential that consistent advice is offered to both carriers and non-carriers of Lynch syndrome.

  12. Clinicopathological Features of Endometrial Carcino-ma Associated with Lynch Syndrome in China

    Institute of Scientific and Technical Information of China (English)

    Yingmei WANG; Fengxia XUE; Russell R. BROADDUS; Xia TAO; Susu XIE; Yanbin ZHU

    2009-01-01

    Background and objective To study the clinicopathoiogical characteristics of Lynch syn&ome-associated endometrial carcinoma in China.Methods Twenty-seven patients who fulfilled the Amsterdam Criteria Ⅱ were classified as having Lynch syndrome-associated endometrial carcinoma (Group A), and 331 patients without a family history of cancer were classified as having sporadic endometrial carcinoma (Group B).Results There were 81 malignancies in 27 Lynch syndrome-associated endometrial carcinoma families, including colorectal cancer (CRC, 24.7%), endometrial carcinoma (21.0%), liver (12.3%), stomach (9.9%), lung (6.2%), and breast (6.2%) cancers. Mean age at time of diagnosis was 49.7 years in Group A and 56.3 years in Group B (P=0.004). Second primary cancers occurred in 33.3% of patients in Group A and 5.1% in Group B (P<0.0001). "Ihe most common second primary cancers were colorectal cancer (44%) and ovarian cancer (22%). The percentage of obese patients was higher in Group A (P=0.013). There was no difference between the two groups in incidence of diabetes mellitns or hypertension or in histological type and FIGO stage. The 5-year survival rates for Group A and B were 96.2% and 79.6%, respectively. Prognosis for Group A was better than for Group B (P=0.045).Conclusion Some clinicopathologicai features of Lynch syndrome-associated endometrial carcinoma, such as early onset and multiple primary carcinomas, are similar in the Chinese and American/European populations. However, the Chinese population had a unique family cancer distribution that included lung and breast cancers. An increased number of grade 1 endometrioid tumors and a better prognosis imply better biobehavior in Chinese Lynch syndrome-associated endometrial carcinoma. Obesity may be a co-contributing factor for development of Lynch syndrome associated endometrial cancer in China.

  13. Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome

    DEFF Research Database (Denmark)

    Drost, Mark; Lützen, Anne; van Hees, Sandrine

    2013-01-01

    In many individuals suspected of the common cancer predisposition Lynch syndrome, variants of unclear significance (VUS), rather than an obviously pathogenic mutations, are identified in one of the DNA mismatch repair (MMR) genes. The uncertainty of whether such VUS inactivate MMR, and therefore...... for the translation of personalized genomics into targeted healthcare....

  14. Informing family members of individuals with Lynch syndrome : a guideline for clinical geneticists

    NARCIS (Netherlands)

    Menko, Fred H.; Aalfs, Cora M.; Henneman, Lidewij; Stol, Yrrah; Wijdenes, Miranda; Otten, Ellen; Ploegmakers, Marleen M. J.; Legemaate, Johan; Smets, Ellen M. A.; de Wert, Guido M. W. R.; Tibben, Aad

    2013-01-01

    The diagnosis of Lynch syndrome can lead to the prevention of colorectal cancer through periodic colonoscopies and removal of premalignant lesions in susceptible individuals. Therefore, predisposed individuals identified by mutation analysis are advised to inform their at-risk relatives about the op

  15. Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance

    DEFF Research Database (Denmark)

    Møller, Pål; Seppälä, Toni; Bernstein, Inge;

    2016-01-01

    OBJECTIVE: Estimates of cancer risk and the effects of surveillance in Lynch syndrome have been subject to bias, partly through reliance on retrospective studies. We sought to establish more robust estimates in patients undergoing prospective cancer surveillance. DESIGN: We undertook a multicentr...

  16. The Kids Are (Mostly) Alright: Second-Generation Assimilation--Comments on Haller, Portes and Lynch

    Science.gov (United States)

    Alba, Richard; Kasinitz, Philip; Waters, Mary C.

    2011-01-01

    This paper presents the authors' comments on "Dreams Fulfilled, Dreams Shattered: Determinants of Segmented Assimilation in the Second Generation" by William Haller, Alejandro Portes and Scott M. Lynch. The overall well-being and integration of second-generation immigrant youth constitute an important topic for researchers and policy makers, one…

  17. Gene variants of unknown clinical significance in Lynch syndrome. An introduction for clinicians

    NARCIS (Netherlands)

    Sijmons, Rolf H.; Greenblatt, Marc S.; Genuardi, Maurizio

    2013-01-01

    Clinicians referring patients for genetic testing for Lynch syndrome will sooner or later receive results for DNA Mismatch Repair (MMR) genes reporting DNA changes that are unclear from a clinical point of view. These changes are referred to as variants of unknown, or unclear, clinical significance

  18. Prediction of MLH1 and MSH2 mutations in lynch syndrome

    NARCIS (Netherlands)

    J. Balmana (Judith); D.H. Stockwell (David); E.W. Steyerberg (Ewout); E.M. Stoffel (Elena); A.M. Deffenbaugh (Amie); J.E. Reid (Julia); B. Ward (Brian); T. Scholl (Thomas); B. Hendrickson (Brant); J. Tazelaar (John); L.A. Burbidge (Lynn); S. Syngal (Sapna)

    2006-01-01

    textabstractContext: Lynch syndrome is caused primarily by mutations in the mismatch repair genes MLH1 and MSH2. Objectives: To analyze MLH1/MSH2 mutation prevalence in a large cohort of patients undergoing genetic testing and to develop a clinical model to predict the likelihood of finding a mutati

  19. Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome

    NARCIS (Netherlands)

    J. Burn (John); D.T. Bishop (David Timothy); J.-P. Mecklin (Jukka-Pekka); F.A. Macrae (Finlay); G. Möslein (Gabriela); S. Olschwang (Sylviane); M.-L. Bisgaard (Marie-Luise); R.S. Ramesar (Rajkumar); D. Eccles (Diana); E.R. Maher (Eamonn); L. Bertario (Lucio); H.J. Jarvinen (Heikki); A. Lindblom (Annika); D.G. Evans (Gareth); J. Lubinski (Jan); P.J. Morrison (Patrick); J.W.C. Ho (Judy); H. Vasen (Hans); L. Side (Lucy); H.J.W. Thomas (Huw ); R.J. Scott (Rodney); M.G. Dunlop (Malcolm); G. Barker (Gail); F. Elliott (Faye); J.R. Jass (Jeremy ); R. Fodde (Riccardo); H. Lynch (Henry); J.C. Mathers (John )

    2008-01-01

    textabstractBACKGROUND: Observational and epidemiologic data indicate that the use of aspirin reduces the risk of colorectal neoplasia; however, the effects of aspirin in the Lynch syndrome (hereditary nonpolyposis colon cancer) are not known. Resistant starch has been associated with an antineoplas

  20. Is surveillance of the small bowel indicated for Lynch syndrome families?

    NARCIS (Netherlands)

    Kate, G.L. ten; Kleibeuker, J.H.; Nagengast, F.M.; Craanen, M.; Cats, A.; Menko, F.H.; Vasen, H.F.

    2007-01-01

    BACKGROUND: Small bowel cancer (SBC) is one of the tumours associated with Lynch syndrome (LS). To advise on screening for this tumour it is paramount to be informed about the lifetime risk. The aim of this study was to calculate the lifetime risk of SBC in LS and to identify possible risk factors.

  1. Is surveillance of the small bowel indicated for Lynch syndrome families?

    NARCIS (Netherlands)

    ten Kate, G. L.; Kleibeuker, J. H.; Nagengast, F. M.; Craanen, M.; Cats, A.; Menko, F. H.; Vasen, H. F. A.

    2007-01-01

    Background: Small bowel cancer (SBC) is one of the tumours associated with Lynch syndrome (LS). To advise on screening for this tumour it is paramount to be informed about the lifetime risk. The aim of this study was to calculate the lifetime risk of SBC in LS and to identify possible risk factors.

  2. Dietary patterns and colorectal adenomas in Lynch syndrome: the GEOLynch cohort study

    NARCIS (Netherlands)

    Botma, A.; Vasen, H.F.; Duijnhoven, F.J.B. van; Kleibeuker, J.H.; Nagengast, F.M.; Kampman, E.

    2013-01-01

    BACKGROUND: Patients with Lynch syndrome (LS) have a high risk of developing colorectal cancer due to mutations in mismatch repair genes. Because dietary factors, alone and in combination, influence sporadic colorectal carcinogenesis, the association of dietary patterns with colorectal adenomas in L

  3. Dietary Patterns and Colorectal Adenomas in Lynch Syndrome The GEOLynch Cohort Study

    NARCIS (Netherlands)

    Botma, Akke; Vasen, Hans F. A.; van Duijnhoven, Franzel J. B.; Kleibeuker, Jan H.; Nagengast, Fokko M.; Kampman, Ellen

    2013-01-01

    BACKGROUND: Patients with Lynch syndrome (LS) have a high risk of developing colorectal cancer due to mutations in mismatch repair genes. Because dietary factors, alone and in combination, influence sporadic colorectal carcinogenesis, the association of dietary patterns with colorectal adenomas in L

  4. Smoking increases the risk for colorectal adenomas in patients with Lynch syndrome

    NARCIS (Netherlands)

    Winkels, R.M.; Botma, A.; Duijnhoven, van F.J.B.; Nagengast, F.M.; Kleibeuker, J.H.; Vasen, H.F.A.; Kampman, E.

    2012-01-01

    Background & Aims Individuals with Lynch syndrome have a high risk of developing colorectal carcinomas and adenomas at a young age, due to inherited mutations in mismatch repair genes. We investigated whether modifiable lifestyle factors, such as smoking and alcohol intake, increase this risk.

  5. Smoking Increases the Risk for Colorectal Adenomas in Patients With Lynch Syndrome

    NARCIS (Netherlands)

    Winkels, Renate M.; Botma, Akke; Van Duijnhoven, Franzel J. B.; Nagengast, Fokko M.; Kleibeuker, Jan H.; Vasen, Hans F. A.; Kampman, Ellen

    BACKGROUND & AIMS: Individuals with Lynch syndrome have a high risk of developing colorectal carcinomas and adenomas at a young age, due to inherited mutations in mismatch repair genes. We investigated whether modifiable lifestyle factors, such as smoking and alcohol intake, increase this risk.

  6. A frame-shift mutation of PMS2 is a widespread cause of Lynch syndrome

    DEFF Research Database (Denmark)

    Clendenning, Mark; Senter, Leigha; Hampel, Heather;

    2008-01-01

    on immunohistochemical analysis. RESULTS: We have identified a frequently occurring frame-shift mutation (c.736_741del6ins11) in 12 ostensibly unrelated Lynch syndrome patients (20% of patients we have identified with a deleterious mutation in PMS2, n=61). These individuals all display the rare allele (population...

  7. Lynch, Urry and city marketing: Taking advantage of the city as a built and graphic image

    NARCIS (Netherlands)

    Hospers, G-J.

    2009-01-01

    City marketing is usually addressed from the perspective of marketing theory. This article follows an alternative approach by exploring city marketing from the viewpoint of urban planning and the sociology of tourism. In his classic ‘The Image of the City’ (1960), planner Kevin Lynch found that peop

  8. Smoking increases the risk for colorectal adenomas in patients with Lynch syndrome

    NARCIS (Netherlands)

    Winkels, R.M.; Botma, A.; Duijnhoven, van F.J.B.; Nagengast, F.M.; Kleibeuker, J.H.; Vasen, H.F.A.; Kampman, E.

    2012-01-01

    Background & Aims Individuals with Lynch syndrome have a high risk of developing colorectal carcinomas and adenomas at a young age, due to inherited mutations in mismatch repair genes. We investigated whether modifiable lifestyle factors, such as smoking and alcohol intake, increase this risk. M

  9. Smoking Increases the Risk for Colorectal Adenomas in Patients With Lynch Syndrome

    NARCIS (Netherlands)

    Winkels, Renate M.; Botma, Akke; Van Duijnhoven, Franzel J. B.; Nagengast, Fokko M.; Kleibeuker, Jan H.; Vasen, Hans F. A.; Kampman, Ellen

    2012-01-01

    BACKGROUND & AIMS: Individuals with Lynch syndrome have a high risk of developing colorectal carcinomas and adenomas at a young age, due to inherited mutations in mismatch repair genes. We investigated whether modifiable lifestyle factors, such as smoking and alcohol intake, increase this risk. METH

  10. Smoking increases the risk for colorectal adenomas in patients with Lynch syndrome.

    NARCIS (Netherlands)

    Winkels, R.M.; Botma, A.; Duijnhoven, F.J.B. van; Nagengast, F.M.; Kleibeuker, J.H.; Vasen, H.F.; Kampman, E.

    2012-01-01

    BACKGROUND & AIMS: Individuals with Lynch syndrome have a high risk of developing colorectal carcinomas and adenomas at a young age, due to inherited mutations in mismatch repair genes. We investigated whether modifiable lifestyle factors, such as smoking and alcohol intake, increase this risk. METH

  11. Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer).

    NARCIS (Netherlands)

    Vasen, H.F.; Moslein, G.; Alonso, A.; Bernstein, I.; Bertario, L.; Blanco, I.; Burn, J.; Capella, G.; Engel, C.; Frayling, I.; Friedl, W.; Hes, F.J.; Hodgson, S.; Mecklin, J.P.; Moller, P.; Nagengast, F.M.; Parc, Y.; Renkonen-Sinisalo, L.; Sampson, J.R.; Stormorken, A.; Wijnen, J.

    2007-01-01

    Lynch syndrome (hereditary non-polyposis colorectal cancer) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. The discovery of these genes, 15 years ago,

  12. The InSiGHT database : utilizing 100 years of insights into Lynch Syndrome

    NARCIS (Netherlands)

    Plazzer, J. P.; Sijmons, R. H.; Woods, M. O.; Peltomaki, P.; Thompson, B.; Den Dunnen, J. T.; Macrae, F.

    2013-01-01

    This article provides a historical overview of the online database (www.insight-group.org/mutations) maintained by the International Society for Gastrointestinal Hereditary Tumours. The focus is on the mismatch repair genes which are mutated in Lynch Syndrome. APC, MUTYH and other genes are also an

  13. HEREDITARY NON-POLYPOSIS COLORECTAL CANCER (LYNCH SYNDROME PADA WANITA UMUR 16 TAHUN

    Directory of Open Access Journals (Sweden)

    Asril Zahari

    2011-09-01

    Full Text Available AbstrakKanker kolorektal menduduki peringkat ketiga jenis kanker yang paling sering terjadi di dunia. Sekitar 3% kasus kanker kolorektal merupakan jenis hereditary non polyposis colorectal cancer (HNPCC/Lynch syndrome, yang sering muncul pada usia muda. Dilaporkan satu kasus di rumah sakit Dr. M. Djamil Padang, wanita berumur 16 tahun dengan keluhan nyeri perut kanan bawah. Didapatkan riwayat penyakit serupa pada kakek, bibi pasien dan enam anggota keluarga yang lain. Pada pemeriksaan fisik abdomen teraba massa dengan konsistensi keras dan terfiksir. Pada kolonoskopi dan biopsi ditemukan tumor jenis adenocarcinoma colon moderatly differentiated di fleksura hepatika dan polip di kolon sigmoid. Berdasarkan kriteria Amsterdam pasien didiagnosa Lynch syndrome. Pada Pasien dilakukan subtotal kolektomi, anastomose ileorectal dan kemoterapi ajuvan. Identifikasi genetik sedang dikerjakan untuk melihat adanya kelainan genetik pada pasien. Pasien melakukan skrining berkala untuk mencegah kanker HNPCC jenis yang lain.Kata kunci : Hereditary non polyposis colorectal cancer, Lynch syndrome, Microsatellite instability, skrining.AbstractCarcinoma colorectal is the third most common type of cancer that occurs in the world. About 2% -3% of cases of colorectal cancer is hereditary non-polyposis colorectal cancer (HNPCC/Lynch syndrome, which often appear at a young age. Amsterdam and Bethesda criteria have been used to identify patients with Lynch syndrome.one case was reported at the Dr. M. Djamil Padang hospital, a 16-year-old girl with right lower abdominal pain. Obtained a history of similar disease in grandparents, aunts and six other family members. On physical examination found palpable fixed abdominal mass with hard consistency in the lower right abdomen. At colonoscopy and biopsy found a moderatly differentiated adenocarcinoma colon type at the hepatic flexure and the sigmoid colon polyp. Based on the Amsterdam criteria, patients diagnosed with HNPCC/Lynch

  14. Limited impact on self-concept in individuals with Lynch syndrome; results from a national cohort study

    DEFF Research Database (Denmark)

    Petersen, Helle Vendel; Esplen, Mary Jane; Ladelund, Steen;

    2011-01-01

    An increasing number of individuals seek genetic counseling and hereby learn about hereditary cancer in the family. Lynch syndrome is associated with an inherited high risk for colorectal and gynecological cancer, but knowledge about how family members at risk perceive their situation is limited....... We used the national Danish HNPCC register to collect data on self-concept from 413 individuals with Lynch syndrome. The recently developed Lynch syndrome self-concept scale contains 20 items within two subscales related to stigma-vulnerability and bowel symptom-related anxiety. Significantly higher...

  15. The post-perspectival: screens and time in David Lynch's Inland Empire

    Directory of Open Access Journals (Sweden)

    Anne Jerslev

    2012-03-01

    Full Text Available Taking Anne Friedberg's notion of the post-perspectival as the point of departure for her analysis of David Lynch's digitally shot and edited Inland Empire from 2006, Anne Jerslev argues that the film deconstructs continuous time and coherent space by constructing multiple planes of representation, multiple layerings of screens and, hence, multiple and fractured modes of perception. The article further suggests that the film's enigmatic structure might best be understood with reference to a new media genre like the website with its hyperlink structure. Finally, the article discusses how a sense of ubiquitous surveillance coalesces with the screen logic.Author Biography Anne Jerslev (PhD is Professor of Film and Media Studies at the Department of Media, Cognition and Communication, University of Copenhagen. Anne Jerslev has published and edited books in Danish and English and published dozens of articles in journals and anthologies in Danish, Scandinavian languages, German and English. Her first book was titled David Lynch i vore øjne (David Lynch in our eyes (1991; it was published in German in 1995 under the title David Lynch—mentale Landschaften. After the Lynch book she published books about cult movies, youth and media and media and intimacy. She has edited two volumes in English, Realism and Reality in Film and Media (2002, where she contributed a piece about Lars von Trier's The Idiots, and Performative Realism (co-edited with Rune Gade (2005. Her latest edited volume (co-edited with Christa Lykke Christensen is Hvor går grænsen? Brudflader i den moderne mediekultur [Are there no limits? The crossing of boundaries in contemporary media culture] (Copenhagen 2010. She is currently editing a volume about “Impure Cinema” together with professor Lúcia Nagib from the University of Leeds, which will appear in 2013. Her own contribution to the book is an article about David Lynch's Interview Project.

  16. Comprehensive population-wide analysis of Lynch syndrome in Iceland reveals founder mutations in MSH6 and PMS2

    DEFF Research Database (Denmark)

    Haraldsdottir, Sigurdis; Rafnar, Thorunn; Frankel, Wendy L

    2017-01-01

    Lynch syndrome, caused by germline mutations in the mismatch repair genes, is associated with increased cancer risk. Here using a large whole-genome sequencing data bank, cancer registry and colorectal tumour bank we determine the prevalence of Lynch syndrome, associated cancer risks...... hypermethylation or mutations in the mismatch repair genes. The population prevalence of Lynch syndrome is 0.442%. We discover a translocation disrupting MLH1 and three mutations in MSH6 and PMS2 that increase endometrial, colorectal, brain and ovarian cancer risk. We find thirteen mismatch repair variants...... and pathogenicity of several variants in the Icelandic population. We use colorectal cancer samples from 1,182 patients diagnosed between 2000-2009. One-hundred and thirty-two (11.2%) tumours are mismatch repair deficient per immunohistochemistry. Twenty-one (1.8%) have Lynch syndrome while 106 (9.0%) have somatic...

  17. Gibraltar Experiment CTD data report, USNS Lynch, 1986-03-26 to 1986-04-19 (NODC Accession 8800167)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile, ocean circulation, and chemical data were collected using CTD casts from the USNS LYNCH in the Gulf of Cadiz, Alboran Sea, and Strait of...

  18. Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer.

    Science.gov (United States)

    Giardiello, Francis M; Allen, John I; Axilbund, Jennifer E; Boland, C Richard; Burke, Carol A; Burt, Randall W; Church, James M; Dominitz, Jason A; Johnson, David A; Kaltenbach, Tonya; Levin, Theodore R; Lieberman, David A; Robertson, Douglas J; Syngal, Sapna; Rex, Douglas K

    2014-08-01

    The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3-6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided.

  19. Doing Violence, Making Race: Southern Lynching and White Racial Group Formation.

    Science.gov (United States)

    Smångs, Mattias

    2016-03-01

    This article presents a theoretical framework of how intergroup violence may figure into the activation and maintenance of group categories, boundaries, and identities, as well as the mediating role played by organizations in such processes. The framework's analytical advantages are demonstrated in an application to southern lynchings. Findings from event- and community-level analyses suggest that "public" lynchings, carried out by larger mobs with ceremonial violence, but not "private" ones, perpetrated by smaller bands without public or ceremonial violence, fed off and into the racial group boundaries, categories, and identities promoted by the southern Democratic Party at the turn of the 20th century and on which the emerging Jim Crow system rested. Highlighting that racialized inequalities cannot be properly understood apart from collective processes of racial group boundary and identity making, the article offers clues to the mechanisms by which past racial domination influences contemporary race relations.

  20. Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome

    DEFF Research Database (Denmark)

    Burn, John; Bishop, D Timothy; Mecklin, Jukka-Pekka

    2008-01-01

    .4%) (relative risk, 1.0; 95% CI, 0.7 to 1.4). Advanced adenomas and colorectal cancers were evenly distributed in the two groups. The prevalence of serious adverse events was low, and the events were evenly distributed. CONCLUSIONS: The use of aspirin, resistant starch, or both for up to 4 years has no effect......BACKGROUND: Observational and epidemiologic data indicate that the use of aspirin reduces the risk of colorectal neoplasia; however, the effects of aspirin in the Lynch syndrome (hereditary nonpolyposis colon cancer) are not known. Resistant starch has been associated with an antineoplastic effect...... on the incidence of colorectal adenoma or carcinoma among carriers of the Lynch syndrome. (Current Controlled Trials number, ISRCTN59521990.)...

  1. [Management and Nursing care for a patient with Lynch syndrome: A case report].

    Science.gov (United States)

    Pacheco-Pérez, Luis Arturo; Guevara Valtier, Milton Carlos

    2016-01-01

    Colorectal cancer is one of the leading causes of death from cancer worldwide. Main interventions to reduce the impact are aimed to enhance prevention and early detection. Results of several studies show that tests such as the fecal occult blood test and colonoscopy are effective for early diagnosis. There are hereditary syndromes such as Lynch Syndrome that can lead to certain types of cancers, including bowel neoplasms, therefore early detection needs to be included as part of the treatment. In these cases, family genetic testing is recommended if the bowel cancer is diagnosed before 50 years old. A care plan including the NANDA (North American Nursing Diagnosis Association), NOC (Nursing Outcomes Classification) and NIC (Nursing Interventions Classification) was developed for a patient with suspected Lynch Syndrome. Nurses should be qualified to identify potential cases of cancer associated with this syndrome, and thus, reduce the likelihood that family members develop the disease, through genetic counseling and education of environmental risk factors.

  2. Urinary Tract Cancer in Lynch Syndrome; Increased Risk in Carriers of MSH2 Mutations

    DEFF Research Database (Denmark)

    Joost, Patrick; Therkildsen, Christina; Dominguez-Valentin, Mev

    2015-01-01

    nonpolyposis colorectal cancer registry was used to identify all 288 Lynch syndrome families in Denmark. Urothelial cancers that developed in mutation carriers and in their first-degree relatives were identified, mismatch-repair status was assessed, clinicopathologic variables were defined, and cumulative......OBJECTIVE: To evaluate the risk of urothelial cancer in the upper urinary tract and the bladder, determine the contribution from the different mismatch-repair genes, and define clinical characteristics of urothelial cancer in Lynch syndrome. MATERIALS AND METHODS: The national hereditary...... lifetime risks were determined. RESULTS: In total, 48 cancers of the ureter, 34 cancers of the renal pelvis, and 54 urinary bladder cancers developed at a mean age of 61 (24-89) years. The tumors were typically of high grade, showed loss of mismatch-repair protein expression in 90% of the tumors...

  3. Lynch syndrome: barriers to and facilitators of screening and disease management

    Directory of Open Access Journals (Sweden)

    Watkins Kathy E

    2011-09-01

    Full Text Available Abstract Background Lynch syndrome is a hereditary cancer with confirmed carriers at high risk for colorectal (CRC and extracolonic cancers. The purpose of the current study was to develop a greater understanding of the factors influencing decisions about disease management post-genetic testing. Methods The study used a grounded theory approach to data collection and analysis as part of a multiphase project examining the psychosocial and behavioral impact of predictive DNA testing for Lynch syndrome. Individual and small group interviews were conducted with individuals from 10 families with the MSH2 intron 5 splice site mutation or exon 8 deletion. The data from confirmed carriers (n = 23 were subjected to re-analysis to identify key barriers to and/or facilitators of screening and disease management. Results Thematic analysis identified personal, health care provider and health care system factors as dominant barriers to and/or facilitators of managing Lynch syndrome. Person-centered factors reflect risk perceptions and decision-making, and enduring screening/disease management. The perceived knowledge and clinical management skills of health care providers also influenced participation in recommended protocols. The health care system barriers/facilitators are defined in terms of continuity of care and coordination of services among providers. Conclusions Individuals with Lynch syndrome often encounter multiple barriers to and facilitators of disease management that go beyond the individual to the provider and health care system levels. The current organization and implementation of health care services are inadequate. A coordinated system of local services capable of providing integrated, efficient health care and follow-up, populated by providers with knowledge of hereditary cancer, is necessary to maintain optimal health.

  4. Lynch syndrome: barriers to and facilitators of screening and disease management.

    Science.gov (United States)

    Watkins, Kathy E; Way, Christine Y; Fiander, Jacqueline J; Meadus, Robert J; Esplen, Mary Jane; Green, Jane S; Ludlow, Valerie C; Etchegary, Holly A; Parfrey, Patrick S

    2011-09-07

    Lynch syndrome is a hereditary cancer with confirmed carriers at high risk for colorectal (CRC) and extracolonic cancers. The purpose of the current study was to develop a greater understanding of the factors influencing decisions about disease management post-genetic testing. The study used a grounded theory approach to data collection and analysis as part of a multiphase project examining the psychosocial and behavioral impact of predictive DNA testing for Lynch syndrome. Individual and small group interviews were conducted with individuals from 10 families with the MSH2 intron 5 splice site mutation or exon 8 deletion. The data from confirmed carriers (n = 23) were subjected to re-analysis to identify key barriers to and/or facilitators of screening and disease management. Thematic analysis identified personal, health care provider and health care system factors as dominant barriers to and/or facilitators of managing Lynch syndrome. Person-centered factors reflect risk perceptions and decision-making, and enduring screening/disease management. The perceived knowledge and clinical management skills of health care providers also influenced participation in recommended protocols. The health care system barriers/facilitators are defined in terms of continuity of care and coordination of services among providers. Individuals with Lynch syndrome often encounter multiple barriers to and facilitators of disease management that go beyond the individual to the provider and health care system levels. The current organization and implementation of health care services are inadequate. A coordinated system of local services capable of providing integrated, efficient health care and follow-up, populated by providers with knowledge of hereditary cancer, is necessary to maintain optimal health.

  5. Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with Lynch syndrome.

    Science.gov (United States)

    Reuschenbach, Miriam; Kloor, Matthias; Morak, Monika; Wentzensen, Nicolas; Germann, Anja; Garbe, Yvette; Tariverdian, Mirjam; Findeisen, Peter; Neumaier, Michael; Holinski-Feder, Elke; von Knebel Doeberitz, Magnus

    2010-06-01

    High level microsatellite instability (MSI-H) occurs in about 15% of colorectal cancer (CRCs), either as sporadic cancers or in the context of hereditary non-polyposis cancer or Lynch syndrome. In MSI-H CRC, mismatch repair deficiency leads to insertion/deletion mutations at coding microsatellites and thus to the translation of frameshift peptides (FSPs). FSPs are potent inductors of T cell responses in vitro and in vivo. The present study aims at the identification of FSP-specific humoral immune responses in MSI-H CRC and Lynch syndrome. Sera from patients with history of MSI-H CRC (n = 69), healthy Lynch syndrome mutation carriers (n = 31) and healthy controls (n = 52) were analyzed for antibodies against FSPs using peptide ELISA. Reactivities were measured against FSPs derived from genes frequently mutated in MSI-H CRCs, AIM2, TGFBR2, CASP5, TAF1B, ZNF294, and MARCKS. Antibody reactivity against FSPs was significantly higher in MSI-H CRC patients than in healthy controls (P = 0.036, Mann-Whitney) and highest in patients with shortest interval between tumor resection and serum sampling. Humoral immune responses in patients were most frequently directed against FSPs derived from mutated TAF1B (11.6%, 8/69) and TGFBR2 (10.1%, 7/69). Low level FSP-specific antibodies were also detected in healthy mutation carriers. Our results show that antibody responses against FSPs are detectable in MSI-H CRC patients and healthy Lynch syndrome mutation carriers. Based on the high number of defined FSP antigens, measuring FSP-specific humoral immune responses is a highly promising tool for future diagnostic application in MSI-H cancer patients.

  6. Sessile serrated polyps of the colorectum are rare in patients with Lynch syndrome and in familial colorectal cancer families

    DEFF Research Database (Denmark)

    Andersen, S H; Lykke, E; Folker, M B

    2008-01-01

    Whereas the generally accepted carcinogenesis pathway of the microsatellite instabile high (MSI-H) colorectal carcinoma (CRC) involves the traditional adenoma in patients with Lynch syndrome, a serrate pathway involving serrate adenomas (SA) and sessile serrate polyps (SSP) characterize the spora......Whereas the generally accepted carcinogenesis pathway of the microsatellite instabile high (MSI-H) colorectal carcinoma (CRC) involves the traditional adenoma in patients with Lynch syndrome, a serrate pathway involving serrate adenomas (SA) and sessile serrate polyps (SSP) characterize...... the FCF, were considered examples of probable SSP. None of the 41 cases coded as adenoma possessed a morphology that qualified as SSP. The prevalence of SSP was not increased as compared to the background population and thus, this serrated lesion does not appear to play a tumorigenic role in Lynch...

  7. Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndrome.

    Science.gov (United States)

    Renkonen-Sinisalo, Laura; Seppälä, Toni T; Järvinen, Heikki J; Mecklin, Jukka-Pekka

    2017-08-01

    The risk of metachronous colorectal cancer is high after surgical resection for first colon cancer in Lynch syndrome. This study aimed to examine whether extended surgery decreases the risk of subsequent colorectal cancer and improves long-term survival. This was a retrospective study. Data were collected from a nationwide registry. Two hundred forty-two Lynch syndrome pathogenic variant carriers who underwent surgery for a first colon cancer from 1984 to 2009 were included. Patients underwent standard segmental colectomy (n = 144) or extended colectomy (n = 98) for colon cancer. Patients were followed a median of 14.6 up to 25 years. Risk of subsequent colorectal cancer in either group, overall and disease-specific survival, and operative mortality were the primary outcomes measured. Subtotal colectomy decreased the risk of subsequent colorectal cancer (HR, 0.20; 95% CI, 0.08-0.52; p = 0.001), compared with segmental resection. Subsequent colorectal cancer decreased in MLH1 carriers. The MSH2 carriers showed no statistical difference, possibly because of their small number. Disease-specific and overall survival within 25 years did not differ between the standard and extended surgeries (82.7% vs 87.2%, p = 0.76 and 47.2% vs 41.4%, p = 0.83). The cumulative risk of subsequent colorectal cancer was 20% in 10 years and 47% within 25 years after standard resection and 4% and 9% after extended surgery. The cumulative risk of metachronous colorectal cancer was 7% within 25 years after subtotal colectomy with ileosigmoidal anastomosis. One patient died of postoperative septicemia within 30 days after segmental colectomy. Data on surgical procedures were primarily collected retrospectively. Lynch syndrome pathogenic variant carriers may undergo subtotal colectomy to manage first colon cancer and avoid repetitive abdominal surgery and to reduce the remaining bowel to facilitate easier endoscopic surveillance. It provides no survival benefit, compared with segmental colon

  8. Validation of a Self-Concept Scale for Lynch Syndrome in Different Nationalities

    DEFF Research Database (Denmark)

    Petersen, Helle Vendel; Domanska, Katarina; Bendahl, Pär-Ola;

    2011-01-01

    syndrome. We compared the performance of this scale in 591 mutation carriers from Denmark, Sweden and Canada. Principal component analysis identified two sets of linked statements-the first related to feeling different, isolated and labeled, and the second to concern and worry about bowel changes....... The scale performed consistently in the three countries. Minor differences were identified, with guilt about passing on a defective gene and feelings of losing one's privacy being more pronounced among Canadians, whereas Danes more often expressed worries about cancer. Validation of the Lynch syndrome self...

  9. Assessing Genetic Variants of Uncertain Significance: The Example of Lynch Syndrome

    DEFF Research Database (Denmark)

    Rasmussen, Lene Juel; Heinen, Christopher D.

    2014-01-01

    variants of uncertain significance (VUS). This leads to anxiety in carriers and noncarrying relatives alike, as well as to an unnecessary burden to preventive healthcare. The establishment of procedures that enable the diagnostic assessment of VUSs in individuals are discussed and hereditary colorectal...... cancer syndrome, Lynch syndrome, is used as an example. This challenge is addressed by illustrating the importance of combining genetic and functional data in future strategies to assess VUS. The proposed strategies combine clinical genetic, analytical, functional and in silico approaches....

  10. The effectiveness of b-lynch sutures in management of atonic postpartum haemorrhage during caesarean section

    Directory of Open Access Journals (Sweden)

    Nidhi Kalkal

    2016-09-01

    Conclusions: This procedure proves to be a valuable addition for surgical treatment of atonic PPH and great advantage in young patients with restoration of future fertility with the added advantage of lesser time of application, lesser blood loss, lesser blood transfusion, lesser skill required. Thus, B-Lynch suturing can be adopted as a mid-step before resorting to uterine devascularisation or hysterectomy when medical line of management fails. [Int J Reprod Contracept Obstet Gynecol 2016; 5(9.000: 2915-2920

  11. Role of the clinical pathology laboratory in the evaluation of endometrial carcinomas for Lynch syndrome.

    Science.gov (United States)

    Djordjevic, Bojana; Broaddus, Russell R

    2014-05-01

    Molecular diagnostic testing of endometrial carcinomas in the pathology laboratory has recently emerged as a key component of the clinical evaluation of Lynch syndrome in many centers. Testing modalities involve immunohistochemical and PCR-based analyses. This article outlines the routine application of these analyses, provides a practical guide for troubleshooting some of the common technical issues related to their performance, and reviews common pitfalls in their interpretation. Discrepancies between tissue testing and genetic testing results are discussed in the context of the current understanding of endometrial cancer biology. The merits of universal versus targeted tissue testing based on clinical patient history and histological tumor appearance are also addressed.

  12. Achieving behaviour change for detection of Lynch syndrome using the Theoretical Domains Framework Implementation (TDFI) approach: a study protocol.

    Science.gov (United States)

    Taylor, Natalie; Long, Janet C; Debono, Deborah; Williams, Rachel; Salisbury, Elizabeth; O'Neill, Sharron; Eykman, Elizabeth; Braithwaite, Jeffrey; Chin, Melvin

    2016-03-12

    Lynch syndrome is an inherited disorder associated with a range of cancers, and found in 2-5 % of colorectal cancers. Lynch syndrome is diagnosed through a combination of significant family and clinical history and pathology. The definitive diagnostic germline test requires formal patient consent after genetic counselling. If diagnosed early, carriers of Lynch syndrome can undergo increased surveillance for cancers, which in turn can prevent late stage cancers, optimise treatment and decrease mortality for themselves and their relatives. However, over the past decade, international studies have reported that only a small proportion of individuals with suspected Lynch syndrome were referred for genetic consultation and possible genetic testing. The aim of this project is to use behaviour change theory and implementation science approaches to increase the number and speed of healthcare professional referrals of colorectal cancer patients with a high-likelihood risk of Lynch syndrome to appropriate genetic counselling services. The six-step Theoretical Domains Framework Implementation (TDFI) approach will be used at two large, metropolitan hospitals treating colorectal cancer patients. Steps are: 1) form local multidisciplinary teams to map current referral processes; 2) identify target behaviours that may lead to increased referrals using discussion supported by a retrospective audit; 3) identify barriers to those behaviours using the validated Influences on Patient Safety Behaviours Questionnaire and TDFI guided focus groups; 4) co-design interventions to address barriers using focus groups; 5) co-implement interventions; and 6) evaluate intervention impact. Chi square analysis will be used to test the difference in the proportion of high-likelihood risk Lynch syndrome patients being referred for genetic testing before and after intervention implementation. A paired t-test will be used to assess the mean time from the pathology test results to referral for high

  13. Ovarian cancer linked to lynch syndrome typically presents as early-onset, non-serous epithelial tumors

    DEFF Research Database (Denmark)

    Bartuma, Katarina; Bernstein, Inge; Malander, Susanne

    2011-01-01

    OBJECTIVE: Heredity is a major cause of ovarian cancer and during recent years the contribution from germline mismatch repair (MMR) gene mutations linked to Lynch syndrome has gradually been recognized. METHODS: We characterized clinical features, tumor morphology and mismatch repair defects in all....... The underlying MMR gene mutations in these families affected MSH2 in 49%, MSH6 in 33% and MLH1 in 17%. Immunohistochemical loss of the corresponding MMR protein was demonstrated in 33/36 (92%) tumors analyzed. CONCLUSION: The combined data from our cohorts demonstrate that ovarian cancer associated with Lynch...

  14. Clinical problems of colorectal cancer and endometrial cancer cases with unknown cause of tumor mismatch repair deficiency (suspected Lynch syndrome

    Directory of Open Access Journals (Sweden)

    Buchanan DD

    2014-10-01

    Full Text Available Daniel D Buchanan,1,2 Christophe Rosty,1,3,4 Mark Clendenning,1 Amanda B Spurdle,5 Aung Ko Win2 1Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, VIC, Australia; 2Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia; 3Envoi Specialist Pathologists, Herston, QLD, Australia; 4School of Medicine, University of Queensland, Herston, QLD, Australia; 5Molecular Cancer Epidemiology Laboratory, Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Herston, QLD, AustraliaAbstract: Carriers of a germline mutation in one of the DNA mismatch repair (MMR genes have a high risk of developing numerous different cancers, predominantly colorectal cancer and endometrial cancer (known as Lynch syndrome. MMR gene mutation carriers develop tumors with MMR deficiency identified by tumor microsatellite instability or immunohistochemical loss of MMR protein expression. Tumor MMR deficiency is used to identify individuals most likely to carry an MMR gene mutation. However, MMR deficiency can also result from somatic inactivation, most commonly methylation of the MLH1 gene promoter. As tumor MMR testing of all incident colorectal and endometrial cancers (universal screening is becoming increasingly adopted, a growing clinical problem is emerging for individuals who have tumors that show MMR deficiency who are subsequently found not to carry an MMR gene mutation after genetic testing using the current diagnostic approaches (Sanger sequencing and multiplex ligation-dependent probe amplification and who also show no evidence of MLH1 methylation. The inability to determine the underlying cause of tumor MMR deficiency in these "Lynch-like" or "suspected Lynch syndrome" cases has significant implications on the clinical management of these individuals and their relatives. When the

  15. Evaluation of Lynch syndrome modifier genes in 748 MMR mutation carriers.

    Science.gov (United States)

    Houlle, Solene; Charbonnier, Françoise; Houivet, Estelle; Tinat, Julie; Buisine, Marie-Pierre; Caron, Olivier; Benichou, Jacques; Baert-Desurmont, Stéphanie; Frebourg, Thierry

    2011-08-01

    Several studies have reported that, in Lynch syndrome resulting from mutations of the mismatch repair (MMR) genes, a CA repeat ≤17 within the IGF1 promoter, SNPs within the xenobiotic metabolizing enzyme gene CYP1A1 and SNPs on 8q23.3 and 11q23.1 modify colorectal cancer (CRC) risk in MMR mutation carriers. We analysed the impact of these polymorphisms on CRC risk in 748 French MMR mutation carriers derived from 359 families. We also analysed the effect of the Novel 1 SNP (18q21), which has recently been shown to increase CRC risk in the general population. We observed a significant difference in the CRC-free survival time between males and females, between MSH2 and MSH6 mutation carriers and between MLH1 and MSH6, indicating that this series is representative of Lynch syndrome. In contrast, the univariate log-rank test, as well as multivariate Cox model analysis controlling for familial aggregation and mutated MMR gene, year of birth and gender showed that the polymorphic alleles tested were not associated with a significant CRC risk increase, neither on the entire sample nor among males and females. This discrepancy with previous reports might be explained both by the genetic heterogeneity between the different populations analysed and the allelic heterogeneity of the MMR mutations. We conclude that genotyping of these polymorphisms is not useful to evaluate CRC risk in MMR mutation carriers and to optimize their clinical follow-up.

  16. Exclusion mapping of a third HNPCC locus in a large Lynch I kindred

    Energy Technology Data Exchange (ETDEWEB)

    Morasse, J.; Khandjian, E.W.; Rousseau, F. [Hopital St-Francois d`Assise, Quebec (Canada)] [and others

    1994-09-01

    Hereditary Non-Polyposis Colorectal Cancer (HNPCC) accounts for 5-10% of all the cases of colorectal cancers. HNPCC can be classified in two clinical forms: (1) Hereditary Site-Specific Colorectal Cancer (HSSCC or Lynch I) and (2) colon cancer associated with extracolonic cancers (Lynch II). Segregation analyses show an autosomal dominant mode of inheritance. In order to identify the HNPCC gene involved in a large Canadian kindred, we performed linkage analysis using microsatellites spanning 9 candidate regions. For all loci tested, the lod score data obtained were negative. Our results demonstrate that the genes hMSH1 and hMLH1 recently reported in HNPCC are not linked in this family. Five loci frequently altered in colorectal tumor cells, APC, MCC, K-ras, p53 and DCC and the DRA gene whose expression is confined to the colon mucosa cells and deregulated in colonic adenomas, are also unlinked to HNPCC susceptibility in this family. We have also excluded chromosomes 4, 5, 8, 11 and 17 as containing the cancer predisposition gene in this family.

  17. Prevalence of somatic mutl homolog 1 promoter hypermethylation in Lynch syndrome colorectal cancer.

    Science.gov (United States)

    Moreira, Leticia; Muñoz, Jenifer; Cuatrecasas, Míriam; Quintanilla, Isabel; Leoz, Maria Liz; Carballal, Sabela; Ocaña, Teresa; López-Cerón, María; Pellise, Maria; Castellví-Bel, Sergi; Jover, Rodrigo; Andreu, Montserrat; Carracedo, Angel; Xicola, Rosa Maria; Llor, Xavier; Boland, Clement Richard; Goel, Ajay; Castells, Antoni; Balaguer, Francesc

    2015-05-01

    Colorectal cancers (CRCs) that have microsatellite instability (MSI) and mutL homolog 1 (MLH1) immunoloss are observed in 3 clinical scenarios: Lynch syndrome (LS), sporadic MSI CRC, and Lynch-like syndrome (LLS). v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) mutational analysis is used to differentiate LS from sporadic MSI CRC. The role of MLH1 promoter methylation status for the differential diagnosis of these clinical forms is not well established. The objectives of this study were: 1) to analyze MLH1 promoter methylation in MLH1-deficient CRCs by pyrosequencing, and 2) to assess its role in the differential diagnosis of MLH1-deficient CRCs. In total, 165 CRCs were analyzed, including LS (n = 19), MSI BRAF-mutated CRC (n = 37), MSI BRAF wild-type CRC (n = 60), and a control group of CRCs without MSI (microsatellite stable [MSS] CRC; n = 49). MLH1 promoter methylation status was analyzed by pyrosequencing, and the ability of different strategies to identify LS was assessed. The average ± standard deviation methylation in LS (9% ± 7%) was significantly lower than that in MSI BRAF-mutated CRC (42% ± 17%; P Cancer Society.

  18. The Use of Social Media to Recruit Participants With Rare Conditions: Lynch Syndrome as an Example.

    Science.gov (United States)

    Burton-Chase, Allison M; Parker, Wendy M; Hennig, Kelsey; Sisson, Faith; Bruzzone, Linda L

    2017-01-23

    Social media is increasingly being used as a means of recruiting participants, particularly for investigators whose areas of interest involve rare conditions or hard-to-reach populations. However, much of the literature to date has focused on paid advertisement recruitment. We used Lynch syndrome (LS), a rare hereditary cancer syndrome, as a model to demonstrate the successful partnership between researchers and a Web-based patient education and advocacy organization to facilitate participant recruitment. Recruitment was undertaken in partnership with Lynch Syndrome International (LSI), an advocacy organization with a strong social media presence. After LSI published our study information, participants followed up via email or phone call. Following prescreening and consent, interested and eligible participants were then sent a secure survey link. Within 36 hours of a single Facebook post by the site administrators for LSI, over 150 individuals responded via phone or email. Sixty-five individuals were sent the survey link and 57 individuals completed the survey (88% response rate). Of note, these 57 individuals were geographically diverse within the Unites States, representing LS patients from 26 different states. This approach has several advantages, including recruitment through a trusted source outside of a clinical setting, higher response rates, and cost-effectiveness with a small research team in a relatively short amount of time. Overall, social media recruitment with a trusted online partner can be highly effective in hard-to-reach clinical populations, such as patients with LS. However, this approach requires additional effort for eligibility screening.

  19. An {sup 57}Fe Mössbauer study of the ordinary chondrite meteorite Lynch 001

    Energy Technology Data Exchange (ETDEWEB)

    Elewa, Nancy N., E-mail: nancy.elewa@student.unsw.edu.au; Cadogan, J. M. [The University of New South Wales at the Australian Defence Force Academy, School of Physical, Environmental and Mathematical Sciences (Australia)

    2017-11-15

    The Lynch 001 meteorite was found in the Nullarbor Plain region of Western Australia in 1977. This meteorite is classified as an ordinary chondrite of the petrologic group L5/6 that has undergone ‘minor to moderate’ terrestrial weathering. Here, we characterize the Fe-bearing phases in this chondrite using {sup 57}Fe Mössbauer spectroscopy carried out over the temperature range 13 K to room temperature (295 K). The paramagnetic doublets of olivine, pyroxene and a superparamagnetic ferric phase dominate the room temperature Mössbauer spectrum. On the basis of the room temperature quadrupole splitting of the olivine component, we estimate its composition to be Fa {sub 30(5)}. Besides the paramagnetic ferric component, accounting for ∼15 % of the spectral area at room temperature, magnetically ordered ferric phases were also detected. The total relative proportion of the Fe {sup 3+} components allows us to estimate the terrestrial age of Lynch 001 to be 6,500 ± 1,500 yr, consistent with the value of 6,700 ± 1,300 yr determined by {sup 14}C dating.

  20. A clinical scoring system to identify patients with sebaceous neoplasms at risk for the Muir-Torre variant of Lynch syndrome.

    Science.gov (United States)

    Roberts, Maegan E; Riegert-Johnson, Douglas L; Thomas, Brittany C; Rumilla, Kandelaria M; Thomas, Colleen S; Heckman, Michael G; Purcell, Jennifer U; Hanson, Nancy B; Leppig, Kathleen A; Lim, Justin; Cappel, Mark A

    2014-09-01

    The Muir-Torre syndrome variant of Lynch syndrome is characterized by the presence of sebaceous neoplasms (adenoma, epithelioma/sebaceoma, carcinoma) and Lynch syndrome-associated cancers (colon, endometrial, and others). Several clinical scoring systems have been developed to identify patients with colon cancer at high risk of Lynch syndrome. However, no such system has been described for patients presenting with sebaceous neoplasms. Based on logistic regression analysis, a scoring system was developed for patients with sebaceous neoplasm to identify those with the highest likelihood of having Muir-Torre syndrome. The final version of the scoring system included variables such as age at presentation of initial sebaceous neoplasm, total number of sebaceous neoplasms, personal history of a Lynch-related cancer, and family history of Lynch-related cancers. Patients with a score of 3 or more were more likely to have Muir-Torre syndrome (28 of 29 patients), those with a score of 2 had intermediate likelihood (12 of 20 patients), and no patient with a score of 0 or 1 was diagnosed with Muir-Torre syndrome. The Mayo Muir-Torre syndrome risk scoring system appears to identify whether patients who present with sebaceous neoplasms are in need of further Lynch syndrome evaluation using easily ascertained clinical information. Abnormal mismatch repair gene immunohistochemistry of a sebaceous neoplasm is a poor predictor in regard to diagnosing Lynch syndrome.

  1. Limited impact on self-concept in individuals with Lynch syndrome; results from a national cohort study

    DEFF Research Database (Denmark)

    Petersen, Helle Vendel; Esplen, Mary Jane; Ladelund, Steen;

    2011-01-01

    An increasing number of individuals seek genetic counseling and hereby learn about hereditary cancer in the family. Lynch syndrome is associated with an inherited high risk for colorectal and gynecological cancer, but knowledge about how family members at risk perceive their situation is limited...

  2. Analysis of Families with Lynch Syndrome Complicated by Advanced Serrated Neoplasia: The Importance of Pathology Review and Pedigree Analysis

    Science.gov (United States)

    Walsh, Michael D; Buchanan, Daniel D; Walters, Rhiannon; Roberts, Aedan; Arnold, Sven; McKeone, Diane; Clendenning, Mark; Ruszkiewicz, Andrew R; Jenkins, Mark A; Hopper, John L; Goldblatt, Jack; George, Jillian; Suthers, Graeme K; Phillips, Kerry; Young, Graeme P; Macrae, Finlay; Drini, Musa; Woods, Michael O; Parry, Susan; Jass, Jeremy R; Young, Joanne P

    2009-01-01

    The identification of Lynch syndrome has been greatly assisted by the advent of tumour immunohistochemistry (IHC) for mismatch repair (MMR) proteins, and by the recognition of the role of acquired somatic BRAF mutation in sporadic MMR-deficient colorectal cancer (CRC). However, somatic BRAF mutation may also be present in the tumours in families with a predisposition to develop serrated polyps in the colorectum. In a subgroup of affected members in these families, CRCs emerge which demonstrate clear evidence of MMR deficiency with absent MLH1 staining and high-level microsatellite instability (MSI). This may result in these families being erroneously classified as Lynch syndrome or, conversely, an individual is considered “sporadic” due to the presence of a somatic BRAF mutation in a tumour. In this report, we describe two Lynch syndrome families who demonstrated several such inconsistencies. In one family, IHC deficiency of both MSH2 and MLH1 was demonstrated in tumours from different affected family members, presenting a confusing diagnostic picture. In the second family, MLH1 loss was observed in the lesions of both MLH1 mutation carriers and those who showed normal MLH1 germline sequence. Both families had Lynch syndrome complicated by an independently segregating serrated neoplasia phenotype, suggesting that in families such as these, tumour and germline studies of several key members, rather than of a single proband, are indicated to clarify the spectrum of risk. PMID:19241144

  3. Body Mass Index Increases Risk of Colorectal Adenomas in Men With Lynch Syndrome : The GEOLynch Cohort Study

    NARCIS (Netherlands)

    Botma, Akke; Nagengast, Fokko M.; Braem, Marieke G. M.; Hendriks, Jan C. M.; Kleibeuker, Jan H.; Vasen, Hans F. A.; Kampman, Ellen

    2010-01-01

    Purpose High body mass index (BMI) is an established risk factor for sporadic colorectal cancer. Still, the influence of BMI on hereditary colorectal cancer (eg, Lynch syndrome [LS]), is unknown. The objective of this study was to assess whether BMI is associated with colorectal adenoma occurrence

  4. Chromosome 8q23.3 and 11q23.1 Variants Modify Colorectal Cancer Risk in Lynch Syndrome

    NARCIS (Netherlands)

    Wijnen, Juul T.; Brohet, Richard M.; Van Eijk, Ronald; Jagmohan-Changur, Shanty; Middeldorp, Anneke; Tops, Carli M.; Van Puijenbroek, Mario; Ausems, Margreet G. E. M.; Garcia, Encarna Gomez; Hes, Frederik J.; Hoogerbrugge, Nicoline; Menko, Fred H.; Van Os, Theo A. M.; Sijmons, Rolf H.; Verhoef, Senno; Wagner, Anja; Nagengast, Fokko M.; Kleibeuker, Jan H.; Devilee, Peter; Morreau, Hans; Goldgar, David; Tomlinson, Ian P.; Houlston, Richard S.; Van Wezel, Tom; Vasen, Hans F. A.

    2009-01-01

    Background & Aims: Recent genome-wide association studies have identified common low-risk variants for colorectal cancer (CRC). To assess whether these influence CRC risk in the Lynch syndrome, we genotyped these variants in a large series of proven mutation carriers. Methods: We studied 675 individ

  5. Sessile serrated polyps of the colorectum are rare in patients with Lynch syndrome and in familial colorectal cancer families

    DEFF Research Database (Denmark)

    Andersen, S H; Lykke, E; Folker, M B;

    2008-01-01

    (FCF) is addressed. Polyps coded as hyperplastic polyps (HP) from subjects with Lynch syndrome and FCF enrolled in the HNPCC-register at the Hvidovre University Hospital as well as adenomas from this population were retrieved and reviewed for features of SSP. Ninety-eight polyps coded as HP and 41...

  6. Lynch syndrome-associated extracolonic tumors are rare in two extended families with the same EPCAM deletion

    NARCIS (Netherlands)

    Lynch, H.T.; Riegert-Johnson, D.L.; Snyder, C.; Lynch, J.F.; Hagenkord, J.; Boland, C.R.; Rhees, J.; Thibodeau, S.N.; Boardman, L.A.; Davies, J.; Kuiper, R.P.; Hoogerbrugge, N.; Ligtenberg, M.J.L.

    2011-01-01

    OBJECTIVES: The Lynch syndrome (LS) is an inherited cancer syndrome showing a preponderance of colorectal cancer (CRC) in context with endometrial cancer and several other extracolonic cancers, which is due to pathogenic mutations in the mismatch repair (MMR) genes, MLH1, MSH2, MSH6, and PMS2. Some

  7. Barriers and Motivators for Referral of Patients with Suspected Lynch Syndrome to Cancer Genetic Services: A Qualitative Study

    Directory of Open Access Journals (Sweden)

    Yen Y. Tan

    2014-02-01

    Full Text Available This article explores the views of general practitioners and specialists on their referral of patients with suspected Lynch syndrome to cancer genetic services. Using a purposive maximum variation sampling strategy, we conducted semi-structured interviews face-to-face with 28 general practitioners and specialists in public or private hospitals and specialist clinics between March and August 2011. General practitioners and specialists were recruited in a major metropolitan area in Australia. Interview transcripts were reviewed by two independent researchers, and thematic analysis was performed using NVivo10 software. The main barriers and motivators identified were: (1 clinician-related (e.g., familiarity with Lynch syndrome and family history knowledge; (2 patient-related (e.g., patients’ interests and personal experience with cancer; and (3 organizational-related (e.g., access to services, guidelines and referral pathway. Referral of patients with suspected Lynch syndrome to cancer genetic services is motivated and hindered by a range of individual, interpersonal and organizational factors. In order to improve the care and quality of life of patients and family with suspected Lynch syndrome, further research is needed to develop supportive tools for clinicians.

  8. Out of Amazonia: the unexpected trans-Andean distribution of Cochranella resplendens (Lynch and Duellman, 1978) (Anura: Centrolenidae).

    Science.gov (United States)

    Molina-Zuluaga, Claudia; Cano, Estefany; Restrepo, Adriana; Rada, Marco; Daza, Juan M

    2017-03-02

    The glassfrog genus Cochranella, with nine recognized species, is distributed in the lowlands and mid elevation of the Neotropical forests, from Nicaragua to Bolivia (Guayasamin et al. 2009; Twomey et al. 2014). Four species are trans-Andean-C. granulosa (Taylor 1949) occurs in the lowlands and mountains, at mid elevation, of Central America, C. litoralis (Ruiz-Carranza & Lynch 1996) and C. mache Guayasamin & Bonaccorso 2004 occur in the Pacific lowlands and the western cloud forests of Colombia and Ecuador, and C. euknemos (Savage & Starrett 1967) occurs both in Central America and South America (northwestern Colombia).-The other five species have cis-Andean distributions in the Amazonian slopes and lowlands, from Colombia to Bolivia: C. nola Harvey 1996, C. guayasamini Twomey, Delia & Castroviejo-Fisher 2014, C. resplendens (Lynch & Duellman 1973), C. erminea Torres-Gastello, Suárez-Segovia & Cisneros-Heredia 2007, and C. phryxa Aguayo-Vedia & Harvey 2006. In Colombia, C. resplendens is known from the foothills of the Amazon versant in Caquetá (Malambo et al. 2013) and Putumayo (Lynch & Duellman 1973; Ruiz-Carranza et al. 1996). The species is also known from Ecuador (Lynch & Duellman 1973) and Peru (Twomey et al. 2014). Here, we report two new records of Cochranella resplendens, extending the species distribution beyond the Amazonian lowlands into the northern Cordillera Central in Colombia.

  9. Rectal Cancer Diagnosed after Cesarean Section in Which High Microsatellite Instability Indicated the Presence of Lynch Syndrome

    Directory of Open Access Journals (Sweden)

    Tomohiro Okuda

    2015-01-01

    Full Text Available We report a case of rectal cancer with microsatellite instability (MSI that probably resulted from Lynch syndrome and that was diagnosed after Cesarean section. The patient was a 28-year-old woman (gravid 1, para 1 without a significant medical history. At 35 gestational weeks, vaginal ultrasonography revealed a 5 cm tumor behind the uterine cervix, which was diagnosed as a uterine myoma. The tumor gradually increased in size and blocked the birth canal, resulting in the patient undergoing an emergency Cesarean section. Postoperatively, the tumor was diagnosed as rectal cancer with MSI. After concurrent chemoradiation therapy, a lower anterior resection was performed. The patient’s family history revealed she met the criteria of the revised Bethesda guidelines for testing the colorectal tumor for MSI. Testing revealed that the tumor did indeed show high MSI and, combined with the family history, suggested this could be a case of Lynch syndrome. Our findings emphasize the importance of considering the possibility of Lynch syndrome in pregnant women with colorectal cancer, particularly those with a family history of this condition. We suggest that the presence of Lynch syndrome should also be considered for any young woman with endometrial, ovarian, or colorectal cancer.

  10. Revised guidelines for the clinical management of Lynch syndrome (HNPCC) : Recommendations by a group of European experts

    NARCIS (Netherlands)

    Vasen, Hans F. A.; Blanco, Ignacio; Aktan-Collan, Katja; Gopie, Jessica P.; Alonso, Angel; Aretz, Stefan; Bernstein, Inge; Bertario, Lucio; Burn, John; Capella, Gabriel; Colas, Chrystelle; Engel, Christoph; Frayling, Ian M.; Genuardi, Maurizio; Heinimann, Karl; Hes, Frederik J.; Hodgson, Shirley V.; Karagiannis, John A.; Lalloo, Fiona; Lindblom, Annika; Mecklin, Jukka-Pekka; Moller, Pal; Myrhoj, Torben; Nagengast, Fokko M.; Parc, Yann; de Leon, Maurizio Ponz; Renkonen-Sinisalo, Laura; Sampson, Julian R.; Stormorken, Astrid; Sijmons, Rolf H.; Tejpar, Sabine; Thomas, Huw J. W.; Rahner, Nils; Wijnen, Juul T.; Jaervinen, Heikki Juhani; Moeslein, Gabriela; Jarvinen, H.J.; Moslein, G.

    2013-01-01

    Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. In 2007, a group of European experts (the Mallorca group) published guidelines for th

  11. Differential expression of CK20, β-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X

    DEFF Research Database (Denmark)

    Haraldsson, Stefan; Klarskov, Louise; Nilbert, Mef

    2017-01-01

    BACKGROUND: Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other...... than MMR proteins. METHODS: We compared the expression patterns of cytokeratins (CK7 and CK20), mucins (MUC2/5 AC/6), CDX2 and β-catenin in Lynch syndrome and FCCTX. RESULTS: Differences were identified for CK20 and nuclear β-catenin, which were significantly more often expressed in FCCTX than in Lynch...

  12. Lynching Luther

    DEFF Research Database (Denmark)

    Backe, Hans-Joachim

    2016-01-01

    police procedurals. The character of DCI John Luther is indicative of the series’ general approach: he is unmistakably constructed from stereotypes of US television, yet not in a straightforward way, as he combines elements of both the impulsive, physical maverick cop and the psychologically adept......, cerebral detective – two character-types traditionally rather juxtaposed as irreconcilable opposites. In this fashion, the overall story arc meshes together elements from Thomas Harris-style serial killer fiction and intuitive detection in the tradition of George Simenon’s Maigret. Similarly...... as the id to his superior Rose Teller’s super-ego and his former partner Ian Reed’s ego, a configuration his subconscious tries to overwrite by juxtaposing those two characters to sociopath Alice Morgan and sophomore detective Justin Ripley. The second season finds Luther at odds with several mother figures...

  13. Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Hong; Zeng, Hong; Lam, Robert; Tempel, Wolfram [University of Toronto, 101 College Street, Toronto, ON M5G 1L7 (Canada); Kerr, Iain D., E-mail: ikerr@myriad.com [Myriad Genetic Laboratories Inc., 320 Wakara Way, Salt Lake City, UT 84108 (United States); Min, Jinrong, E-mail: ikerr@myriad.com [University of Toronto, 101 College Street, Toronto, ON M5G 1L7 (Canada); University of Toronto, Toronto, ON M5G 1L7 (Canada)

    2015-07-28

    The crystal structure of the human MLH1 N-terminus is reported at 2.30 Å resolution. The overall structure is described along with an analysis of two clinically important mutations. Mismatch repair prevents the accumulation of erroneous insertions/deletions and non-Watson–Crick base pairs in the genome. Pathogenic mutations in the MLH1 gene are associated with a predisposition to Lynch and Turcot’s syndromes. Although genetic testing for these mutations is available, robust classification of variants requires strong clinical and functional support. Here, the first structure of the N-terminus of human MLH1, determined by X-ray crystallography, is described. The structure shares a high degree of similarity with previously determined prokaryotic MLH1 homologs; however, this structure affords a more accurate platform for the classification of MLH1 variants.

  14. Bayesian Modeling for Genetic Anticipation in Presence of Mutational Heterogeneity: A Case Study in Lynch Syndrome

    DEFF Research Database (Denmark)

    Boonstra, Philip S; Mukherjee, Bhramar; Taylor, Jeremy M G;

    2011-01-01

    inferential conclusions. We compare the fit of four-candidate random effects distributions via Bayesian model fit diagnostics. A related statistical issue here is isolating the confounding effect of changes in secular trends, screening, and medical practices that may affect time to disease detection across...... to cause hereditary nonpolyposis colorectal cancer, also called Lynch syndrome (LS). We find evidence for a decrease in AOO between generations in this article. Our model predicts family-level anticipation effects that are potentially useful in genetic counseling clinics for high-risk families....... birth cohorts. Using historic cancer registry data, we borrow from relative survival analysis methods to adjust for changes in age-specific incidence across birth cohorts. Our motivating case study comes from a Danish cancer register of 124 families with mutations in mismatch repair (MMR) genes known...

  15. Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations

    DEFF Research Database (Denmark)

    Nielsen, Sofie V,; Stein, Amelie; Dinitzen, Alexander B.

    2017-01-01

    Accurate methods to assess the pathogenicity of mutations are needed to fully leverage the possibilities of genome sequencing in diagnosis. Current data-driven and bioinformatics approaches are, however, limited by the large number of new variations found in each newly sequenced genome, and often...... and for diagnosis of Lynch syndrome, and perhaps other hereditary diseases.......Accurate methods to assess the pathogenicity of mutations are needed to fully leverage the possibilities of genome sequencing in diagnosis. Current data-driven and bioinformatics approaches are, however, limited by the large number of new variations found in each newly sequenced genome, and often...... do not provide direct mechanistic insight. Here we demonstrate, for the first time, that saturation mutagenesis, biophysical modeling and co-variation analysis, performed in silico, can predict the abundance, metabolic stability, and function of proteins inside living cells. As a model system, we...

  16. Molecular testing in colorectal cancer: diagnosis of Lynch syndrome and personalized cancer medicine.

    Science.gov (United States)

    Shi, Chanjuan; Washington, Kay

    2012-06-01

    Currently, molecular testing in colorectal cancer (CRC) is aimed at detecting Lynch syndrome and predicting response to anti-epidermal growth factor receptor (EGFR) therapies. However, CRC is a complex disease, with at least 3 molecular pathways of carcinogenesis. The importance of the EGFR signaling pathway in colorectal carcinogenesis is underscored by the availability of anti-EGFR monoclonal antibodies for the treatment of some metastatic CRCs. Potentially, mutations in any of the genes in the EGFR signaling pathway may be associated with prognosis and may predict response to anti-EGFR or other targeted therapies. Although not currently the standard of care, molecular testing of CRCs is expanding to include mutational analysis of the genes in the EGFR pathway, in addition to more widely performed tests for identifying cancers with high microsatellite instability. Multiplex molecular prognostic panels for therapeutic decision making in stage II CRCs also represent expanding use of molecular testing for this common cancer.

  17. The Use of Social Media to Recruit Participants With Rare Conditions: Lynch Syndrome as an Example

    Science.gov (United States)

    Parker, Wendy M; Hennig, Kelsey; Sisson, Faith; Bruzzone, Linda L

    2017-01-01

    Background Social media is increasingly being used as a means of recruiting participants, particularly for investigators whose areas of interest involve rare conditions or hard-to-reach populations. However, much of the literature to date has focused on paid advertisement recruitment. Objective We used Lynch syndrome (LS), a rare hereditary cancer syndrome, as a model to demonstrate the successful partnership between researchers and a Web-based patient education and advocacy organization to facilitate participant recruitment. Methods Recruitment was undertaken in partnership with Lynch Syndrome International (LSI), an advocacy organization with a strong social media presence. After LSI published our study information, participants followed up via email or phone call. Following prescreening and consent, interested and eligible participants were then sent a secure survey link. Results Within 36 hours of a single Facebook post by the site administrators for LSI, over 150 individuals responded via phone or email. Sixty-five individuals were sent the survey link and 57 individuals completed the survey (88% response rate). Of note, these 57 individuals were geographically diverse within the Unites States, representing LS patients from 26 different states. Conclusions This approach has several advantages, including recruitment through a trusted source outside of a clinical setting, higher response rates, and cost-effectiveness with a small research team in a relatively short amount of time. Overall, social media recruitment with a trusted online partner can be highly effective in hard-to-reach clinical populations, such as patients with LS. However, this approach requires additional effort for eligibility screening. PMID:28115298

  18. Whole Gene Capture Analysis of 15 CRC Susceptibility Genes in Suspected Lynch Syndrome Patients.

    Directory of Open Access Journals (Sweden)

    Anne M L Jansen

    Full Text Available Lynch Syndrome (LS is caused by pathogenic germline variants in one of the mismatch repair (MMR genes. However, up to 60% of MMR-deficient colorectal cancer cases are categorized as suspected Lynch Syndrome (sLS because no pathogenic MMR germline variant can be identified, which leads to difficulties in clinical management. We therefore analyzed the genomic regions of 15 CRC susceptibility genes in leukocyte DNA of 34 unrelated sLS patients and 11 patients with MLH1 hypermethylated tumors with a clear family history.Using targeted next-generation sequencing, we analyzed the entire non-repetitive genomic sequence, including intronic and regulatory sequences, of 15 CRC susceptibility genes. In addition, tumor DNA from 28 sLS patients was analyzed for somatic MMR variants.Of 1979 germline variants found in the leukocyte DNA of 34 sLS patients, one was a pathogenic variant (MLH1 c.1667+1delG. Leukocyte DNA of 11 patients with MLH1 hypermethylated tumors was negative for pathogenic germline variants in the tested CRC susceptibility genes and for germline MLH1 hypermethylation. Somatic DNA analysis of 28 sLS tumors identified eight (29% cases with two pathogenic somatic variants, one with a VUS predicted to pathogenic and LOH, and nine cases (32% with one pathogenic somatic variant (n = 8 or one VUS predicted to be pathogenic (n = 1.This is the first study in sLS patients to include the entire genomic sequence of CRC susceptibility genes. An underlying somatic or germline MMR gene defect was identified in ten of 34 sLS patients (29%. In the remaining sLS patients, the underlying genetic defect explaining the MMRdeficiency in their tumors might be found outside the genomic regions harboring the MMR and other known CRC susceptibility genes.

  19. Germline mutation analysis of MLH1 and MSH2 in Malaysian Lynch syndrome patients

    Institute of Scientific and Technical Information of China (English)

    Mohd Nizam Zahary; Gurjeet Kaur; Muhammad Radzi Abu Hassan; Harjinder Singh; Venkatesh R Naik; Ravindran Ankathil

    2012-01-01

    AIM:To investigate the protein expression profile of mismatch repair (MMR) genes in suspected cases of Lynch syndrome and to characterize the associated germline mutations.METHODS:Immunohistochemical analysis of tumor samples was performed to determine the protein expression profile of MMR protein.Germline mutation screening was carried out on peripheral blood samples.The entire exon regions of MLH1 and MSH2 genes were amplified by polymerase chain reaction,screened by denaturing high performance liquid chromatography (dHPLC) and analyzed by DNA sequencing to characterize the germline mutations.RESULTS:Three out of 34 tissue samples (8.8%) and four out of 34 tissue samples (11.8%) showed loss of nuclear staining by immunohistochemistry,indicating the absence of MLH1 and MSH2 protein expression in carcinoma cells,respectively.dHPLC analysis followed by DNA sequencing showed these samples to have germline mutations of MSH2 gene.However,no deleterious mutations were identified in any of the 19 exons or coding regions of MLH1 gene,but we were able to identify MLH1 promoter polymorphism,-93G >A (rs1800734),in 21 out of 34 patients (61.8%).We identified one novel mutation,transversion mutation c.2005G > C,which resulted in a missense mutation (Gly669Arg),a transversion mutation in exon 1,c.142G > T,which resulted in a nonsense mutation (Glu48Stop)and splice-site mutation,c.2006-6T > C,which was adjacent to exon 13 of MSH2 gene.CONCLUSION:Germline mutations were identified in four Malaysian Lynch syndrome patients.Immunohistochemical analysis of tumor tissue proved to be a good pre-screening test before proceeding to germline mutation analysis of DNA MMR genes.

  20. Development and validation of an instrument to measure the impact of genetic testing on self-concept in Lynch syndrome

    DEFF Research Database (Denmark)

    Esplen, M J; Stuckless, N; Gallinger, S

    2011-01-01

    with two dimensions identified through factor analysis: stigma/vulnerability and bowel symptom-related anxiety. The scale showed excellent reliability (Cronbach's α = 0.93), good convergent validity by a high correlation with impact of event scale (r(102) = 0.55, p self-esteem scale......Esplen MJ, Stuckless N, Gallinger S, Aronson M, Rothenmund H, Semotiuk K, Stokes J, Way C, Green J, Butler K, Petersen HV, Wong J. Development and validation of an instrument to measure the impact of genetic testing on self-concept in Lynch syndrome. A positive genetic test result may impact...... on a person's self-concept and affect quality of life. The purpose of the study was to develop a self-concept scale to measure such impact for individuals carrying mutations for a heritable colorectal cancer Lynch syndrome (LS). Two distinct phases were involved: Phase 1 generated specific colorectal self...

  1. A de novo germline MLH1 mutation in a Lynch syndrome patient with discordant immunohistochemical and molecular biology test results

    Institute of Scientific and Technical Information of China (English)

    Fabrice Airaud; Sébastien Küry; Isabelle Valo; Ingrid Maury; Dominique Bonneau; Olivier Ingster; Stéphane Bezieau

    2012-01-01

    We describe a patient with a Homo sapiens mutL homolog 1 (MLH1)-associated Lynch syndrome with previous diagnoses of two distinct primary cancers:a sigmoid colon cancer at the age of 39 years,and a right colon cancer at the age of 50 years.The mutation identified in his blood and buccal cells,c.1771delG,p.Asp591Ilefs*25,appears to be a de novo event,as it was not transmitted by either of his parents.This type of de novo event is rare in MLH1 as only three cases have been reported in the literature so far.Furthermore,the discordant results observed between replication error phenotyping and immunohistochemistry highlight the importance of the systematic use of both pre-screening tests in the molecular diagnosis of Lynch syndrome.

  2. Mismatch repair-deficient crypt foci in Lynch syndrome--molecular alterations and association with clinical parameters.

    Directory of Open Access Journals (Sweden)

    Laura Staffa

    Full Text Available Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR genes, most frequently MLH1 and MSH2. Recently, MMR-deficient crypt foci (MMR-DCF have been identified as a novel lesion which occurs at high frequency in the intestinal mucosa from Lynch syndrome mutation carriers, but very rarely progress to cancer. To shed light on molecular alterations and clinical associations of MMR-DCF, we systematically searched the intestinal mucosa from Lynch syndrome patients for MMR-DCF by immunohistochemistry. The identified lesions were characterised for alterations in microsatellite-bearing genes with proven or suspected role in malignant transformation. We demonstrate that the prevalence of MMR-DCF (mean 0.84 MMR-DCF per 1 cm2 mucosa in the colorectum of Lynch syndrome patients was significantly associated with patients' age, but not with patients' gender. No MMR-DCF were detectable in the mucosa of patients with sporadic MSI-H colorectal cancer (n = 12. Microsatellite instability of at least one tested marker was detected in 89% of the MMR-DCF examined, indicating an immediate onset of microsatellite instability after MMR gene inactivation. Coding microsatellite mutations were most frequent in the genes HT001 (ASTE1 with 33%, followed by AIM2 (17% and BAX (10%. Though MMR deficiency alone appears to be insufficient for malignant transformation, it leads to measurable microsatellite instability even in single MMR-deficient crypts. Our data indicate for the first time that the frequency of MMR-DCF increases with patients' age. Similar patterns of coding microsatellite instability in MMR-DCF and MMR-deficient cancers suggest that certain combinations of coding microsatellite mutations, including mutations of the HT001, AIM2 and BAX gene, may contribute to the progression of MMR-deficient lesions into MMR-deficient cancers.

  3. A Subgeneric Classification of the Genus Uranotaenia Lynch Arribalzaga, with a Historical Review and Notes on Other Categories

    Science.gov (United States)

    1972-01-01

    first applied by Lynch Arribalzaga in 1891. It was derived from the Greek and Latin combinations of urano (heaven) and taenia (band or stripe) in...have been seen in the subgenus Urano taenia d Other secondary characters seen in Pseudoficalbia only are conspicuous setae at or near the apical...o o e ANNULATA SERIES Although a few of these characters are found in other Urano- taenia species, the peculiar larval head seta 1-C in the annulata

  4. Family perspectives in lynch syndrome becoming a family at risk, patterns of communication and influence on relations

    Directory of Open Access Journals (Sweden)

    Bartuma Katarina

    2012-05-01

    Full Text Available Abstract Background A growing number of individuals are diagnosed with hereditary cancer. Though increased levels of anxiety and depression have been demonstrated around the time of genetic counselling, most individuals handle life at increased risk well. Data have, however, been collected on individual basis, which led us to focus on family perspectives of hereditary cancer. Methods Lynch syndrome represents a major type of hereditary colorectal and gynaecological cancer. We preformed open-ended interviews with 27 informants from 9 Lynch syndrome families. Inductive content analysis revealed three major themes: transition to a risk family, patterns of communication and influence on family relations and individual roles. Results Family members described how learning about Lynch syndrome shifted focus from daily issues to concerns about cancer. Changes in communication related to difficulties in talking to children about heredity and informing new family members and distant relatives about an increased risk of cancer. Influence on relations was exemplified by family members taking on different roles, e.g. females often being responsible for coordinating information about heredity and providing support. Families in which members had experienced cancer at young age typically informed children soon after learning about heredity and at young age, whereas families with experience of cancer at higher age postponed information and thereby also genetic counselling. Conclusions Three major family perspectives are described in Lynch syndrome families; becoming a risk family, patterns of communication and influence on family relations. Since these issues are central, our findings suggests that such family perspectives should be considered during genetic counselling in order to contribute to information spread, help family members cope with the increased risk, and motivate family members at risk to undergo surveillance.

  5. Contribution of Large Genomic Rearrangements in Italian Lynch Syndrome Patients: Characterization of a Novel Alu-Mediated Deletion

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    Francesca Duraturo

    2013-01-01

    Full Text Available Lynch syndrome is associated with germ-line mutations in the DNA mismatch repair (MMR genes, mainly MLH1 and MSH2. Most of the mutations reported in these genes to date are point mutations, small deletions, and insertions. Large genomic rearrangements in the MMR genes predisposing to Lynch syndrome also occur, but the frequency varies depending on the population studied on average from 5 to 20%. The aim of this study was to examine the contribution of large rearrangements in the MLH1 and MSH2 genes in a well-characterised series of 63 unrelated Southern Italian Lynch syndrome patients who were negative for pathogenic point mutations in the MLH1, MSH2, and MSH6 genes. We identified a large novel deletion in the MSH2 gene, including exon 6 in one of the patients analysed (1.6% frequency. This deletion was confirmed and localised by long-range PCR. The breakpoints of this rearrangement were characterised by sequencing. Further analysis of the breakpoints revealed that this rearrangement was a product of Alu-mediated recombination. Our findings identified a novel Alu-mediated rearrangement within MSH2 gene and showed that large deletions or duplications in MLH1 and MSH2 genes are low-frequency mutational events in Southern Italian patients with an inherited predisposition to colon cancer.

  6. Interval colon cancer in a Lynch syndrome patient under annual colonoscopic surveillance: a case for advanced imaging techniques?

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    Oxentenko Amy S

    2012-05-01

    Full Text Available Abstract Background Lynch syndrome confers increased risk for various malignancies, including colorectal cancer. Colonoscopic surveillance programs have led to reduced incidence of colorectal cancer and reduced mortality from colorectal cancer. Colonoscopy every 1–2 years beginning at age 20–25, or 10 years earlier than the first diagnosis of colorectal cancer in a family, with annual colonoscopy after age 40, is the recommended management for mutation carriers. Screening programs have reduced colon cancer mortality, but interval cancers may occur. Case presentation We describe a 48-year-old woman with Lynch syndrome who was found to have an adenoma with invasive colorectal cancer within one year after a normal colonoscopy. Conclusion Our patient illustrates two current concepts about Lynch syndrome: 1 adenomas are the cancer precursor and 2 such adenomas may be “aggressive,” in the sense that the adenoma progresses more readily and more rapidly to carcinoma in this setting compared to usual colorectal adenomas. Our patient’s resected tumor invaded only into submucosa and all lymph nodes were negative; in that sense, she represents a success for annual colonoscopic surveillance. Still, this case does raise the question of whether advanced imaging techniques are advisable for surveillance colonoscopy in these high-risk patients.

  7. Syndrome de Lynch: à propos d'un cas et revue de la litterature

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    Bouguenouch, Laila; Samri, Imane; Belhassan, Khadija; Sayel, Hanane; Abbassi, Meriame; Bennis, Sanae; Benajah, Dafr Allah; Ibrahimi, Adil; Amarti, Afaf; Ouldim, Karim

    2016-01-01

    Le syndrome de Lynch, ou cancer colorectal héréditaire sans polypose ou HNPCC (hereditary non-polyposis colorectal cancer), est la forme la plus fréquente de cancer colorectal héréditaire. Il conduit à une augmentation de la susceptibilité à développer des cancers, au premier rang le cancer colorectal, le cancer de l'endomètre chez les femmes, et dans une moindre mesure, d'autres cancers (ovaire, intestin grêle, estomac, voies excrétrices urinaires et hépatobiliaires). Ainsi, le risque cumulé de développer un cancer colorectal ou de l'endomètre à l’âge de 80 ans s’élève respectivement à 20 et 40%. Ces cancers sont caractérisés par leur contexte d'atteinte familiale, leur survenue à un âge précoce, ainsi que par le développement de cancers métachrones chez un même individu. Ce syndrome se transmet de manière autosomique dominante. Les gènes dont l'altération est associée à l'existence d'un syndrome HNPCC appartiennent à la famille des gènes de réparation des mésappariements de l'ADN (DNA mismatch repair ou MMR): MSH2, MLH1 et MSH6 sont impliqués, par ordre décroissant de fréquence, dans respectivement 35%, 25% et 2% des cas. Une surveillance coloscopique et gynécologique est proposée aux personnes porteuses d'une mutation constitutionnelle du gène MSH2, MLH1 ou MSH6. Nous rapportons une des premières observations marocaines d'un syndrome de Lynch dont la mutation constitutionnelle du gène MLH1 a été identifiée chez un des membres de la famille atteint d'un cancer du côlon. Suite à la demande d'autres sujets sains de la même famille, un diagnostic presymptomatique a été effectué conduisant à une stratégie de surveillance adaptée. A travers notre observation nous illustrons le rôle de l'oncogénétique dans la prise en charge des patients cancéreux et de leurs familles. PMID:27642480

  8. Novel Mutations in MLH1 and MSH2 Genes in Mexican Patients with Lynch Syndrome

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    Moreno-Ortiz, Jose Miguel; Ayala-Madrigal, María de la Luz; Corona-Rivera, Jorge Román; Maciel-Gutiérrez, Víctor; Franco-Topete, Ramón Antonio; Armendáriz-Borunda, Juan; Pérez-Carbonell, Lucia; Rhees, Jennifer; Gutiérrez-Angulo, Melva

    2016-01-01

    Background. Lynch Syndrome (LS) is characterized by germline mutations in the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2. This syndrome is inherited in an autosomal dominant pattern and is characterized by early onset colorectal cancer (CRC) and extracolonic tumors. The aim of this study was to identify mutations in MMR genes in three Mexican patients with LS. Methods. Immunohistochemical analysis was performed as a prescreening method to identify absent protein expression. PCR, Denaturing High Performance Liquid Chromatography (dHPLC), and Sanger sequencing complemented the analysis. Results. Two samples showed the absence of nuclear staining for MLH1 and one sample showed loss of nuclear staining for MSH2. The mutations found in MLH1 gene were c.2103+1G>C in intron 18 and compound heterozygous mutants c.1852_1854delAAG (p.K618del) and c.1852_1853delinsGC (p.K618A) in exon 16. In the MSH2 gene, we identified mutation c.638dupT (p.L213fs) in exon 3. Conclusions. This is the first report of mutations in MMR genes in Mexican patients with LS and these appear to be novel. PMID:27247567

  9. Novel Mutations in MLH1 and MSH2 Genes in Mexican Patients with Lynch Syndrome

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    Jose Miguel Moreno-Ortiz

    2016-01-01

    Full Text Available Background. Lynch Syndrome (LS is characterized by germline mutations in the DNA mismatch repair (MMR genes MLH1, MSH2, MSH6, and PMS2. This syndrome is inherited in an autosomal dominant pattern and is characterized by early onset colorectal cancer (CRC and extracolonic tumors. The aim of this study was to identify mutations in MMR genes in three Mexican patients with LS. Methods. Immunohistochemical analysis was performed as a prescreening method to identify absent protein expression. PCR, Denaturing High Performance Liquid Chromatography (dHPLC, and Sanger sequencing complemented the analysis. Results. Two samples showed the absence of nuclear staining for MLH1 and one sample showed loss of nuclear staining for MSH2. The mutations found in MLH1 gene were c.2103+1G>C in intron 18 and compound heterozygous mutants c.1852_1854delAAG (p.K618del and c.1852_1853delinsGC (p.K618A in exon 16. In the MSH2 gene, we identified mutation c.638dupT (p.L213fs in exon 3. Conclusions. This is the first report of mutations in MMR genes in Mexican patients with LS and these appear to be novel.

  10. Recognition of Lynch Syndrome Amongst Newly Diagnosed Colorectal Cancers at St. Paul’s Hospital

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    Steven Pi

    2017-01-01

    Full Text Available Background. Lynch Syndrome (LS is the most common cause of inherited colorectal cancer (CRC. In British Columbia, most centres still use clinical criteria (Amsterdam II, Revised Bethesda, or the BC Cancer Agency’s criteria to determine who should undergo further first-line testing in the form of microsatellite instability or immunohistochemistry staining. Given the limitations with this strategy, LS is thought to be underrecognized. Objective. To investigate whether LS is truly underrecognized when compared to the reported prevalence. Methods. A retrospective chart review of all CRC cases diagnosed at St. Paul’s Hospital from 2010 to 2013 was conducted. Results. 246 patients met inclusion criteria. 76% (83/109 with a family history of malignancy were unable to recall the specific malignancy or age of diagnosis. 18% (43/235 were only asked about a history of gastrointestinal related malignancy and 26% (65/246 met at least one of the three criteria but only 21% (13/63 received further investigation. Only 1.6% (4/246 had LS compared to the reported prevalence of 2–5% of all CRC cases. Conclusion. This data supports our hypothesis that LS is underrecognized. Issues at the patient, physician, and systems level need to be evaluated to determine where the limitations preventing appropriate testing are occurring.

  11. Molecular profile of the Lynch Syndrome in the Republic of Macedonia

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    Marija Hiljadnikova-Bajro

    2012-12-01

    Full Text Available The most frequent type of hereditary colorectal cancer, the one occurring in the setting of the Lynch syndrome (LS is considered a phenotypic manifestation of a germline defect in the mismatch repair mechanism i.e. in the MLH1, MSH2, MSH6 or PMS2 gene. Aiming towards establishment of a standardized protocol involving molecular analyses for diagnosis of this syndrome and developing a unique national register of families with hereditary colorectal cancer syndromes in the Republic of Macedonia, we began a prospective study to reveal the genetic defects among Macedonian patients with colorectal cancer (CRC and identifying families with hereditary CRC. A total of 53 patients fulfilling the revised Bethesda criteria for MSI-genetic testing were compared to 350 patients with sporadic CRC. The results reveal significant differences in age at diagnosis (p=0.03, involvement of microsatellite instability (pG nonsense mutation with a possible founder effect in the Macedonian population, the MLH1 ex.3-12 deletion, as well as the c.244A>G mutation, IVS14- 19A>G and IVS4+65A>C changes in MLH1 without confirmed pathological significance. The observed high frequency (87.5% of the Ile219Val (c.655A>G variant in MLH1 among the LS suspects prompts further analyses to evaluate its involvement in the development of hereditary CRC by itself or as a risk modifying factor among the patients from the Republic of Macedonia.

  12. Estimating successive cancer risks in Lynch Syndrome families using a progressive three-state model.

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    Choi, Yun-Hee; Briollais, Laurent; Green, Jane; Parfrey, Patrick; Kopciuk, Karen

    2014-02-20

    Lynch Syndrome (LS) families harbor mutated mismatch repair genes,which predispose them to specific types of cancer. Because individuals within LS families can experience multiple cancers over their lifetime, we developed a progressive three-state model to estimate the disease risk from a healthy (state 0) to a first cancer (state 1) and then to a second cancer (state 2). Ascertainment correction of the likelihood was made to adjust for complex sampling designs with carrier probabilities for family members with missing genotype information estimated using their family's observed genotype and phenotype information in a one-step expectation-maximization algorithm. A sandwich variance estimator was employed to overcome possible model misspecification. The main objective of this paper is to estimate the disease risk (penetrance) for age at a second cancer after someone has experienced a first cancer that is also associated with a mutated gene. Simulation study results indicate that our approach generally provides unbiased risk estimates and low root mean squared errors across different family study designs, proportions of missing genotypes, and risk heterogeneities. An application to 12 large LS families from Newfoundland demonstrates that the risk for a second cancer was substantial and that the age at a first colorectal cancer significantly impacted the age at any LS subsequent cancer. This study provides new insights for developing more effective management of mutation carriers in LS families by providing more accurate multiple cancer risk estimates.

  13. Bayesian modeling for genetic anticipation in presence of mutational heterogeneity: a case study in Lynch syndrome.

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    Boonstra, Philip S; Mukherjee, Bhramar; Taylor, Jeremy M G; Nilbert, Mef; Moreno, Victor; Gruber, Stephen B

    2011-12-01

    Genetic anticipation, described by earlier age of onset (AOO) and more aggressive symptoms in successive generations, is a phenomenon noted in certain hereditary diseases. Its extent may vary between families and/or between mutation subtypes known to be associated with the disease phenotype. In this article, we posit a Bayesian approach to infer genetic anticipation under flexible random effects models for censored data that capture the effect of successive generations on AOO. Primary interest lies in the random effects. Misspecifying the distribution of random effects may result in incorrect inferential conclusions. We compare the fit of four-candidate random effects distributions via Bayesian model fit diagnostics. A related statistical issue here is isolating the confounding effect of changes in secular trends, screening, and medical practices that may affect time to disease detection across birth cohorts. Using historic cancer registry data, we borrow from relative survival analysis methods to adjust for changes in age-specific incidence across birth cohorts. Our motivating case study comes from a Danish cancer register of 124 families with mutations in mismatch repair (MMR) genes known to cause hereditary nonpolyposis colorectal cancer, also called Lynch syndrome (LS). We find evidence for a decrease in AOO between generations in this article. Our model predicts family-level anticipation effects that are potentially useful in genetic counseling clinics for high-risk families.

  14. Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation.

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    Snowsill, Tristan; Coelho, Helen; Huxley, Nicola; Jones-Hughes, Tracey; Briscoe, Simon; Frayling, Ian M; Hyde, Chris

    2017-09-01

    Inherited mutations in deoxyribonucleic acid (DNA) mismatch repair (MMR) genes lead to an increased risk of colorectal cancer (CRC), gynaecological cancers and other cancers, known as Lynch syndrome (LS). Risk-reducing interventions can be offered to individuals with known LS-causing mutations. The mutations can be identified by comprehensive testing of the MMR genes, but this would be prohibitively expensive in the general population. Tumour-based tests - microsatellite instability (MSI) and MMR immunohistochemistry (IHC) - are used in CRC patients to identify individuals at high risk of LS for genetic testing. MLH1 (MutL homologue 1) promoter methylation and BRAF V600E testing can be conducted on tumour material to rule out certain sporadic cancers. To investigate whether testing for LS in CRC patients using MSI or IHC (with or without MLH1 promoter methylation testing and BRAF V600E testing) is clinically effective (in terms of identifying Lynch syndrome and improving outcomes for patients) and represents a cost-effective use of NHS resources. Systematic reviews were conducted of the published literature on diagnostic test accuracy studies of MSI and/or IHC testing for LS, end-to-end studies of screening for LS in CRC patients and economic evaluations of screening for LS in CRC patients. A model-based economic evaluation was conducted to extrapolate long-term outcomes from the results of the diagnostic test accuracy review. The model was extended from a model previously developed by the authors. Ten studies were identified that evaluated the diagnostic test accuracy of MSI and/or IHC testing for identifying LS in CRC patients. For MSI testing, sensitivity ranged from 66.7% to 100.0% and specificity ranged from 61.1% to 92.5%. For IHC, sensitivity ranged from 80.8% to 100.0% and specificity ranged from 80.5% to 91.9%. When tumours showing low levels of MSI were treated as a positive result, the sensitivity of MSI testing increased but specificity fell. No end

  15. Phenotypic Heterogeneity by Germline Mismatch Repair Gene Defect in Lynch Syndrome Patients.

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    Hernâni-Eusébio, Jorge; Barbosa, Elisabete

    2016-10-01

    Introdução: A síndrome de Lynch é a forma hereditária mais comum de cancro colo-rectal, sendo também responsável por cancro do endométrio e de outros tipos. Associa-se a mutações germinativas nos genes de mismatch repair do ADN e a instabilidade de microssatélites. As mutações MLH1 e MSH2 têm um fenótipo de síndrome de Lynch ‘clássico’, sendo o MSH2 mais associado a cancro extra-cólico. Mutações do MSH6 e PMS2 têm um fenótipo atípico. A expressão clínica é heterogénea, existindo uma correlação entre o gene mismatch repair mutado e o padrão fenotípico. Material e Métodos: Análise retrospetiva dos dados clínicos de doentes que cumpriam os critérios de Amesterdão ou que tinha mutações nos genes mismatch repair, entre setembro de 2012 e outubro de 2015. Resultados: Identificámos 28 doentes. Dezassete tinham cancro colo-rectal sendo a localização no cólon direito predominante. Cinco tiveram cancro do endométrio (mediana da idade de diagnóstico – 53), sem qualquer mutação no MSH6. Cinco desenvolveram outros cancros. Todos os casos com mutações mismatch repair estudados tinham instabilidade de microssatélites. Discussão: Na maioria dos casos foi encontrada mutação no MSH2 apesar de o MLH1 ser descrito na literatura como o gene mais frequentemente mutado. Interessa dizer que os doentes com cancro colo-rectal não evidenciam uma tendência para ter muito infiltrado inflamatório. Na maioria dos casos foi realizada colectomia parcial apesar da incidência elevada de lesões síncronas e metácronas associadas. Histerectomia e anexectomia profilática foi realizada em doentes em menopausa/perimenopausa. Conclusão: O registo standardizado dos dados dos doentes poderá levar a um melhor acompanhamento e conhecimento desta síndrome. O uso das Guidelines de Bethesda poderá identificar novos casos que escapam aos critérios de Amesterdão. A pesquisa de instabilidade de microssatélites deve ser feita em muito maior n

  16. Educational and Psychosocial Support Needs in Lynch Syndrome: Implementation and Assessment of an Educational Workshop and Support Group.

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    Corines, Marina J; Hamilton, Jada G; Glogowski, Emily; Anrig, Chris A; Goldberg, Rachael; Niehaus, Kate; Salo-Mullen, Erin; Harlan, Megan; Sheehan, Margaret R; Trottier, Magan; Ahsraf, Asad; Tran, Christina; Jacobs, Lauren; Rau-Murthy, Rohini; Lincoln, Anne G; Robson, Mark E; Guillem, Jose G; Markowitz, Arnold J; Offit, Kenneth; Stadler, Zsofia K

    2017-04-01

    Few reports of educational and counseling support resources exist for Lynch syndrome (LS), a disorder requiring multi-organ cancer screening and specialized medical care throughout adult life. Here we describe the development and efficacy of two resources designed to address this need, the Memorial Sloan Kettering Cancer Center Clinical Genetics Service annual Lynch Syndrome Educational Workshop (LSEW), and a quarterly Lynch Syndrome Patient Advocacy Network (LSPAN) support group. The LSEW and LSPAN were implemented beginning in 2012. Participant survey data evaluating satisfaction, clarity, and unmet needs for each event were retrospectively analyzed and summarized using descriptive statistics. Annual LSEW attendance ranged from 53 to 75 total participants. LSEW year 1 participants indicated a need for a support group, and preferred in-person meetings at a frequency of every 3-6 months. For LSEW year 2-5 participants, >96 % reported satisfaction with the LSEW, and >82 % expressed interest in secure online support. Common themes for improvement included increased time for question and answer sessions and additional introductory genetics education. Responding LSPAN participants (n = 57 total survey responses in 11 meetings) found the meetings helpful (100 %), information clear (91 %), and presence of a genetic counselor useful (67 %). Desired discussion topics included coping with stress and anxiety, development of a support network, family communication about LS, genetic testing decisions, and bereavement. Following genetic counseling, a need exists for ongoing educational and emotional support in LS. Implementation of resources such as the LSEW and LSPAN is feasible and perceived as helpful by participants.

  17. Is there evidence that we should screen the general population for Lynch syndrome with genetic testing? A systematic review

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    Prince, Anya E R; Cadigan, R Jean; Henderson, Gail E; Evans, James P; Adams, Michael; Coker-Schwimmer, Emmanuel; Penn, Dolly C; Van Riper, Marcia; Corbie-Smith, Giselle; Jonas, Daniel E

    2017-01-01

    Background The emerging dual imperatives of personalized medicine and technologic advances make population screening for preventable conditions resulting from genetic alterations a realistic possibility. Lynch syndrome is a potential screening target due to its prevalence, penetrance, and the availability of well-established, preventive interventions. However, while population screening may lower incidence of preventable conditions, implementation without evidence may lead to unintentional harms. We examined the literature to determine whether evidence exists that screening for Lynch-associated mismatch repair (MMR) gene mutations leads to improved overall survival, cancer-specific survival, or quality of life. Documenting evidence and gaps is critical to implementing genomic approaches in public health and guiding future research. Materials and methods Our 2014–2015 systematic review identified studies comparing screening with no screening in the general population, and controlled studies assessing analytic validity of targeted next-generation sequencing, and benefits or harms of interventions or screening. We conducted meta-analyses for the association between early or more frequent colonoscopies and health outcomes. Results Twelve studies met our eligibility criteria. No adequate evidence directly addressed the main question or the harms of screening in the general population. Meta-analyses found relative reductions of 68% for colorectal cancer incidence (relative risk: 0.32, 95% confidence interval: 0.23–0.43, three cohort studies, 590 participants) and 78% for all-cause mortality (relative risk: 0.22, 95% confidence interval: 0.09–0.56, three cohort studies, 590 participants) for early or more frequent colonoscopies among family members of people with cancer who also had an associated MMR gene mutation. Conclusion Inadequate evidence exists examining harms and benefits of population-based screening for Lynch syndrome. Lack of evidence highlights the need

  18. Management strategies in Lynch syndrome and familial adenomatous polyposis: a national healthcare survey in Japan.

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    Yamano, Tomoki; Hamanaka, Michiko; Babaya, Akihito; Kimura, Kei; Kobayashi, Masayoshi; Fukumoto, Miki; Tsukamoto, Kiyoshi; Noda, Masafumi; Matsubara, Nagahide; Tomita, Naohiro; Sugihara, Kenichi

    2017-02-01

    Lynch syndrome (LS) and familial adenomatous polyposis (FAP) are major sources of hereditary colorectal cancer (CRC) and are associated with other malignancies. There is some heterogeneity in management strategies in Japan. We undertook a survey of management of hereditary CRC in hospitals that are members of the Japan Society of Colorectal Cancer Research. One hundred and ninety departments responded, of which 127 were from designated cancer care hospitals (DCCHs) according to the Japanese government. There were 25 488 operations for CRC in these departments in 2015. The DCCHs performed better with regard to usage of Japan Society of Colorectal Cancer Research guidelines, referring new CRC patients for LS screening, and having in-house genetic counselors and knowledge of treatment for LS. There were 174 patients diagnosed with LS and 602 undergoing follow-up in 2011-2015, which is fewer than the number expected from CRC operations in 2015. These numbers were not affected by whether the institution was a DCCH. Universal screening for LS was carried out in 8% of the departments. In contrast, 541 patients were diagnosed with FAP and 273 received preventive proctocolectomy/colectomy in 2011-2015. The DCCH departments undertook more surgery than non-DCCH departments, although most of the management, including surgical procedures and use of non-steroidal anti-inflammatory drugs, was similar. Management of desmoid tumor in the abdominal cavity differed according to the number of patients treated. In conclusion, there was heterogeneity in management of LS but not FAP. Most patients with LS may be overlooked and universal screening for LS is not common in Japan.

  19. Prevalence of Lynch syndrome in a Middle Eastern population with colorectal cancer.

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    Siraj, Abdul K; Prabhakaran, Sarita; Bavi, Prashant; Bu, Rong; Beg, Shaham; Hazmi, Mohsen Al; Al-Rasheed, Maha; Al-Assiri, Mohammed; Sairafi, Rami; Al-Dayel, Fouad; Al-Sanea, Nasser; Uddin, Shahab; Al-Kuraya, Khawla S

    2015-06-01

    Lynch syndrome (LS; hereditary nonpolyposis colorectal cancer) is a common cause of hereditary colorectal cancer (CRC). CRC is the most common cancer diagnosed among males in Saudi Arabia but to the authors' knowledge there is a lack of data regarding the prevalence of LS in patients with CRC. There currently are no clear guidelines for the selection criteria for these patients to screen for LS. A comprehensive molecular characterization was performed in a cohort of 807 CRC cases by immunohistochemical and microsatellite analysis using polymerase chain reaction. BRAF mutation screening, high CpG island methylator phenotype, and analysis for germline mutations were performed in 425 CRC samples. These were all high microsatellite instability (MSI-H) samples (91 cases), all low MSI samples (143 cases), and selected cases from the microsatellite stable group (191 cases) that met revised Bethesda guidelines. Polymerase chain reaction identified 91 MSI-H cases (11.3%) and sequencing revealed mismatch repair germline mutations in 8 CRC cases only. Of the total of 807 CRC cases, these 8 cases (0.99%) were MSI-H, met the revised Bethesda guidelines, and did not harbor BRAF mutations. The results of the current study confirmed cases of LS in approximately 1.0% of CRC samples and reflects the efficacy of screening among MSI-H cases that lack BRAF mutations. This comprehensive study from Saudi Arabia will help in implementing a universal screening/reflex testing strategy in a clinical setting in Saudi Arabia and in conducting a national screening program that benefits both patients and their relatives. © 2015 American Cancer Society.

  20. Aspirin, Ibuprofen, and the Risk for Colorectal Cancer in Lynch Syndrome

    Science.gov (United States)

    Ait Ouakrim, Driss; Dashti, Seyedeh Ghazaleh; Chau, Rowena; Buchanan, Daniel D.; Clendenning, Mark; Rosty, Christophe; Winship, Ingrid M.; Young, Joanne P.; Giles, Graham G.; Leggett, Barbara; Macrae, Finlay A.; Ahnen, Dennis J.; Casey, Graham; Gallinger, Steven; Haile, Robert W.; Le Marchand, Loïc; Thibodeau, Stephen N.; Lindor, Noralane M.; Newcomb, Polly A.; Potter, John D.; Baron, John A.; Hopper, John L.; Jenkins, Mark A.

    2015-01-01

    Background: Inheritance of a germline mutation in one of the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 causes a high risk of colorectal and other cancers (Lynch Syndrome). Use of aspirin has been shown to be associated with a reduced risk of colorectal cancer for the general population as well as for MMR gene mutation carriers. The aim of this study was to determine whether use of aspirin and ibuprofen in a nontrial setting is associated with the risk of colorectal cancer risk for MMR gene mutation carriers. Methods: We included 1858 participants in the Colon Cancer Family Registry who had been found to have a pathogenic germline mutation in a MMR gene (carriers). We used weighted Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). All statistical tests were two-sided. Results: A total of 714 carriers (38%) were diagnosed with colorectal cancer at a mean age of 42.4 (standard deviation 10.6) years. A reduced risk of colorectal cancer was associated with aspirin use (for 1 month to 4.9 years: HR = 0.49, 95% CI = 0.27 to 0.90, P = .02; for ≥5 years: HR = 0.25, 95% CI = 0.10 to 0.62, P = .003) and ibuprofen use (for 1 month to 4.9 years: HR = 0.38, 95% CI = 0.18 to 0.79, P = .009; for ≥5 years: HR = 0.26, 95% CI = 0.10 to 0.69, P = .007), compared with less than one month of use. Conclusion: Our results provide additional evidence that, for MMR gene mutation carriers, use of aspirin and ibuprofen might be effective in reducing their high risk of colorectal cancer. PMID:26109217

  1. A Systematic Review on the Existing Screening Pathways for Lynch Syndrome Identification

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    Alessia Tognetto

    2017-09-01

    Full Text Available BackgroundLynch syndrome (LS is the most common hereditary colon cancer syndrome, accounting for 3–5% of colorectal cancer (CRC cases, and it is associated with the development of other cancers. Early detection of individuals with LS is relevant, since they can take advantage of life-saving intensive care surveillance. The debate regarding the best screening policy, however, is far from being concluded. This prompted us to conduct a systematic review of the existing screening pathways for LS.MethodsWe performed a systematic search of MEDLINE, ISI Web of Science, and SCOPUS online databases for the existing screening pathways for LS. The eligibility criteria for inclusion in this review required that the studies evaluated a structured and permanent screening pathway for the identification of LS carriers. The effectiveness of the pathways was analyzed in terms of LS detection rate.ResultsWe identified five eligible studies. All the LS screening pathways started from CRC cases, of which three followed a universal screening approach. Concerning the laboratory procedures, the pathways used immunohistochemistry and/or microsatellite instability testing. If the responses of the tests indicated a risk for LS, the genetic counseling, performed by a geneticist or a genetic counselor, was mandatory to undergo DNA genetic testing. The overall LS detection rate ranged from 0 to 5.2%.ConclusionThis systematic review reported different existing pathways for the identification of LS patients. Although current clinical guidelines suggest to test all the CRC cases to identify LS cases, the actual implementation of pathways for LS identification has not been realized. Large-scale screening programs for LS have the potential to reduce morbidity and mortality for CRC, but coordinated efforts in educating all key stakeholders and addressing public needs are still required.

  2. Lynch syndrome and exposure to aristolochic acid in upper-tract urothelial carcinoma: its clinical impact?

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    Colin, Pierre; Seisen, Thomas; Mathieu, Romain; Shariat, Sharohkh F.

    2016-01-01

    The purpose of the current review was to describe the clinical risk for Lynch syndrome (LS) after exposure to aristolochic acid (AA) in cases of upper urinary-tract urothelial carcinoma (UTUC). A systematic review of the scientific literature was performed using the Medline database (National Library of Medicine, PubMed) using the following keywords: epidemiology, risk factor, AA, Balkan nephropathy (BNe), LS, hereditary cancer, hereditary non-polyposis colorectal cancer (HNPCC), mismatch repair genes, urothelial carcinomas, upper urinary tract, renal pelvis, ureter, Amsterdam criteria, genetic counselling, mismatch repair genes, genetic instability, microsatellite, and Bethesda guidelines. LS is a specific risk for UTUC, which is the third most frequent cancer (in its tumor spectrum) after colon and uterine lesions. Mutation of the MSH2 gene is the most commonly described cause of UTUC in LS. Diagnosis is based on clinical suspicion and is guided by Bethesda and Amsterdam criteria. It is secondarily confirmed by immunohistochemical analyses of the tumor and a search for gene mutations. The presence of LS in patients with UTUC is a favorable prognosis factor for survival during follow-ups. AA is a specific environmental risk factor for UTUC and tubulo-interstitial nephropathy. It has been involved in the development of nephropathies in link with the Balkan disease and intake of Chinese herbal medicine. More broadly, the use of traditional plant medicines from the genus Aristolochia has created worldwide public-health concerns. UTUCs share common risk factors with other urothelial carcinomas such as tobacco or occupational exposure. However, these tumors have also specific risk factors such as AA exposure and LS that clinicians should be aware of because of their clinical implication in further management and follow-up.

  3. MLH1 promoter hypermethylation in the analytical algorithm of Lynch syndrome: a cost-effectiveness study

    Science.gov (United States)

    Gausachs, Mireia; Mur, Pilar; Corral, Julieta; Pineda, Marta; González, Sara; Benito, Llúcia; Menéndez, Mireia; Espinàs, Josep Alfons; Brunet, Joan; Iniesta, María Dolores; Gruber, Stephen B; Lázaro, Conxi; Blanco, Ignacio; Capellá, Gabriel

    2012-01-01

    The analytical algorithm of Lynch syndrome (LS) is increasingly complex. BRAF V600E mutation and MLH1 promoter hypermethylation have been proposed as a screening tool for the identification of LS. The aim of this study was to assess the clinical usefulness and cost-effectiveness of both somatic alterations to improve the yield of the diagnostic algorithm of LS. A total of 122 colorectal tumors from individuals with family history of colorectal cancer that showed microsatellite instability and/or loss of mismatch repair (MMR) protein expression were studied. MMR germline mutations were detected in 57 cases (40 MLH1, 15 MSH2 and 2 MSH6). BRAF V600E mutation was assessed by single-nucleotide primer extension. MLH1 promoter hypermethylation was assessed by methylation-specific multiplex ligation-dependent probe amplification in a subset of 71 cases with loss of MLH1 protein. A decision model was developed to estimate the incremental costs of alternative case-finding methods for detecting MLH1 mutation carriers. One-way sensitivity analysis was performed to assess robustness of estimations. Sensitivity of the absence of BRAF mutations for depiction of LS patients was 96% (23/24) and specificity was 28% (13/47). Specificity of MLH1 promoter hypermethylation for depiction of sporadic tumors was 66% (31/47) and sensitivity of 96% (23/24). The cost per additional mutation detected when using hypermethylation analysis was lower when compared with BRAF study and germinal MLH1 mutation study. Somatic hypermethylation of MLH1 is an accurate and cost-effective pre-screening method in the selection of patients that are candidates for MLH1 germline analysis when LS is suspected and MLH1 protein expression is absent. PMID:22274583

  4. Iconografía, música y narración en Wild at Heart, de David Lynch

    OpenAIRE

    García Escrivá, Vicente

    2011-01-01

    El análisis del texto fílmico Corazón Salvaje (Wild at Heart, David Lynch, EEUU, 1990) permite localizar toda una serie de rasgos característicos de la narrativa y la estética cinematográfica posmoderna. Por un lado, el film presenta una notable descomposición narrativa, lo que se traduce en una sucesión de escenas un tanto inconexas, a modo de cuadros intensos pero poco trabados. Asimismo, en la película se produce una suerte de hibridación de géneros, aglutinados por un tono general de paro...

  5. The role of religious and existential well-being in families with Lynch syndrome: prevention, family communication, and psychosocial adjustment.

    Science.gov (United States)

    Morris, Bronwyn A; Hadley, Donald W; Koehly, Laura M

    2013-08-01

    This study explored the role of religious (RWB) and existential well-being (EWB) on psychosocial factors, support network characteristics, and screening practices in families with Lynch syndrome, also referred to as hereditary nonpolyposis colon cancer (HNPCC). Participants were individuals with Lynch syndrome associated cancers and their first-degree relatives at risk of inheriting an identified deleterious mutation. Analyses considered both family RWB and EWB norms and individual deviations from that norm. Analyses controlled for age, gender, cancer diagnosis, number of respondents, and network size. Higher family RWB was associated with increased depressive symptoms (p family EWB was related to decreased depression symptoms (p family EWB was associated with fecal occult blood testing (p family communication about genetic counselling and testing (p family-level effects. Individuals with lower EWB than their family had lower perceived risk for colorectal cancer (p communicated disease risk information to less family members (p family also had higher cancer worry (p family network and being aware of family characteristics which may impact individual adjustment to disease risk. Interventions considering family-level factors may provide efficient pathways to improving psychosocial factors, screening practices, communication about disease risk and genetic testing, and cancer prevention.

  6. Cost-Effectiveness Analysis of Different Genetic Testing Strategies for Lynch Syndrome in Taiwan.

    Science.gov (United States)

    Chen, Ying-Erh; Kao, Sung-Shuo; Chung, Ren-Hua

    2016-01-01

    Patients with Lynch syndrome (LS) have a significantly increased risk of developing colorectal cancer (CRC) and other cancers. Genetic screening for LS among patients with newly diagnosed CRC aims to identify mutations in the disease-causing genes (i.e., the DNA mismatch repair genes) in the patients, to offer genetic testing for relatives of the patients with the mutations, and then to provide early prevention for the relatives with the mutations. Several genetic tests are available for LS, such as DNA sequencing for MMR genes and tumor testing using microsatellite instability and immunohistochemical analyses. Cost-effectiveness analyses of different genetic testing strategies for LS have been performed in several studies from different countries such as the US and Germany. However, a cost-effectiveness analysis for the testing has not yet been performed in Taiwan. In this study, we evaluated the cost-effectiveness of four genetic testing strategies for LS described in previous studies, while population-specific parameters, such as the mutation rates of the DNA mismatch repair genes and treatment costs for CRC in Taiwan, were used. The incremental cost-effectiveness ratios based on discounted life years gained due to genetic screening were calculated for the strategies relative to no screening and to the previous strategy. Using the World Health Organization standard, which was defined based on Taiwan's Gross Domestic Product per capita, the strategy based on immunohistochemistry as a genetic test followed by BRAF mutation testing was considered to be highly cost-effective relative to no screening. Our probabilistic sensitivity analysis results also suggest that the strategy has a probability of 0.939 of being cost-effective relative to no screening based on the commonly used threshold of $50,000 to determine cost-effectiveness. To the best of our knowledge, this is the first cost-effectiveness analysis for evaluating different genetic testing strategies for LS in

  7. Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome : the GEOLynch cohort study

    NARCIS (Netherlands)

    Jung, Audrey Y.; van Duijnhoven, Franzel J. B.; Nagengast, Fokko M.; Botma, Akke; Heine-Broring, Renate C.; Kleibeuker, Jan H.; Vasen, Hans F. A.; Harryvan, Jan L.; Winkels, Renate M.; Kampman, Ellen

    Dietary intake of B vitamins and methionine, essential components of DNA synthesis and methylation pathways, may influence colorectal tumor (CRT) development. The impact of B vitamins on colorectal carcinogenesis in individuals with Lynch syndrome (LS) is unknown but is important given their high

  8. Ovarian metastasis from uveal melanoma with MLH1/PMS2 protein loss in a patient with germline MLH1 mutated Lynch syndrome: consequence or coincidence?

    Science.gov (United States)

    Lobo, João; Pinto, Carla; Freitas, Micaela; Pinheiro, Manuela; Vizcaino, Rámon; Oliva, Esther; Teixeira, Manuel R; Jerónimo, Carmen; Bartosch, Carla

    2017-03-01

    Currently, uveal melanoma is not considered within the Lynch syndrome tumor spectrum. However, there are studies suggesting a contribution of microsatellite instability in sporadic uveal melanoma tumorigenesis. We report a 45-year-old woman who was referred for genetic counseling due to a family history of Lynch syndrome caused by a MLH1 mutation. She originally underwent enucleation of the right eye secondary to a uveal spindle cell melanoma diagnosed at age 25. The tumor recurred 22 years later presenting as an ovarian metastasis and concurrently a microscopic endometrial endometrioid carcinoma, grade 1/3 was diagnosed. Subsequent studies highlighted that the uveal melanoma showed high microsatellite instability and loss of MLH1 and PMS2 protein expression, with no MLH1 promoter methylation or BRAF mutation. Additionally, a GNAQ mutation was found. We conclude that our patient's uveal melanoma is most likely related to MLH1 germline mutation and thus Lynch syndrome related. To the best of our knowledge, this is the first report of uveal melanoma showing MLH1/PMS2 protein loss in the context of Lynch syndrome.

  9. Los actos tienen consecuencias. Lógicas del mind-game film en la trilogía de Los Ángeles de David Lynch

    NARCIS (Netherlands)

    Elsaesser, T.

    2013-01-01

    Actions Do Have Consequences. Logics of the Mind-Game Film in David Lynch’s Los Angeles-Trilogy. David Lynch is a director, along with other auteurs, notably Michael Haneke and Lars von Trier, whose authorial identity and creative authority —and the challenges these encounter in the 21st century— ar

  10. Los actos tienen consecuencias. Lógicas del mind-game film en la trilogía de Los Ángeles de David Lynch

    NARCIS (Netherlands)

    Elsaesser, T.

    2013-01-01

    Actions Do Have Consequences. Logics of the Mind-Game Film in David Lynch’s Los Angeles-Trilogy. David Lynch is a director, along with other auteurs, notably Michael Haneke and Lars von Trier, whose authorial identity and creative authority —and the challenges these encounter in the 21st century—

  11. Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome : the GEOLynch cohort study

    NARCIS (Netherlands)

    Jung, Audrey Y.; van Duijnhoven, Franzel J. B.; Nagengast, Fokko M.; Botma, Akke; Heine-Broring, Renate C.; Kleibeuker, Jan H.; Vasen, Hans F. A.; Harryvan, Jan L.; Winkels, Renate M.; Kampman, Ellen

    2014-01-01

    Dietary intake of B vitamins and methionine, essential components of DNA synthesis and methylation pathways, may influence colorectal tumor (CRT) development. The impact of B vitamins on colorectal carcinogenesis in individuals with Lynch syndrome (LS) is unknown but is important given their high li

  12. 大卫·林奇的生平和作品%David Lynch's Biography and Filmmography

    Institute of Scientific and Technical Information of China (English)

    游飞

    2003-01-01

    @@ 生平 大卫·林奇(David Lynch)是现代美国电影创作的伟大复兴者,一个受到广泛赞誉的编剧兼导演,他还是电视制片人、摄影家、动画专家、作曲家和电脑影像艺术家.运用惊人的平衡感和技巧游走于主流电影和先锋电影的边缘,林奇为电影银幕带来一种怪诞、黑暗和诡异不安的真实感,一种由极端的暴力、怪异的喜剧和奇妙的美丽为特征的噩梦世界.

  13. Temperature profiles from expendable bathythermograph (XBT) casts from the LYNCH in the North Atlantic Ocean in support of the Integrated Global Ocean Services System (IGOSS) project from 26 June 1973 to 14 July 1973 (NODC Accession 7301081)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — XBT data were collected from the LYNCH in support of the Integrated Global Ocean Services System (IGOSS) project. Data were collected US Navy; Naval Oceanographic...

  14. The Uterine Sandwich Method for Placenta Previa Accreta in Mullerian Anomaly: Combining the B-Lynch Compression Suture and an Intrauterine Gauze Tampon

    Directory of Open Access Journals (Sweden)

    Mustafa Kaplanoğlu

    2013-01-01

    Full Text Available Mullerian duct anomalies may cause obstetric complications, such as postpartum hemorrhage (PPH and placental adhesion anomalies. Uterine compression suture may be useful for controlling PPH (especially atony. In recent studies, uterine compression sutures have been used in placenta accreta. We report a case of PPH, a placenta accreta accompanying a large septae, treated with B-Lynch suture and intrauterine gauze tampon.

  15. Ambiguity and the Ethics of Reading Race and Lynching in James W. Johnson’s The Autobiography of an Ex-Colored Man (1912

    Directory of Open Access Journals (Sweden)

    Dexl, Carmen

    2009-01-01

    Full Text Available James Weldon Johnson’s novel The Autobiography of an Ex-Colored Man (1912 discusses the causes, conditions, and implications of passing in a segregated society. The essay argues that the novel’s aesthetics of ambiguity conveys and reflects an ambivalence towards the concept of race. Using theories of Geoffrey Galt Harpham and John Guillory, it elaborates an ethics of reading race and lynching in The Autobiography of an Ex-Colored Man.

  16. Effect of low B-Lynch suture on menstrual cycle recovery and sex hormone levels in patients after cesarean section for placenta previa

    Institute of Scientific and Technical Information of China (English)

    Su-Lan Zhang; Wan-Cheng Feng; Yan Mi

    2016-01-01

    Objective:To explore the effect of low B-Lynch suture on the menstrual cycle recovery and sex hormone levels in patients after cesarean section for placenta previa.Methods:A total of 40 patients who were admitted in our hospital from August, 2013 to August, 2015 for cesarean section due to placenta previa were included in the study and randomized into the observation group and the control group. The patients in the observation group were given low B-lynch suture, while in the control group, yarns were plugged in the uterus. The bleeding during operation and 24 h after operation, the postpartum lochia duration, and menstrual cycle recovery in the two groups were observed. The postpartum FSH, E2, and LH levels in the two groups were determined.Results:The amount of bleeding during operation and 24 h after operation in the observation group was significantly less than that in the control group (P0.05). The comparison of FSH, E2, and LH levels between the two groups was not statistically significant (P>0.05).Conclusions:Low B-Lynch suture can effectively reduce the amount of bleeding after cesarean section for placenta previa, and has no effect on the menstrual recovery and ovarian function with a simple operation and less postoperative complications; therefore, it deserves to be widely recommended in the clinic.

  17. LINCHAMENTO: O CRESCIMENTO DA (INJUSTIÇA COLETIVA DIANTE DA OMISSÃO DO ESTADO / LYNCHING: GROWTH OF PUBLIC (INJUSTICE FRONT THE FAILURE OF THE STATE

    Directory of Open Access Journals (Sweden)

    Sarah Ludmilla do Nascimento Félix

    2015-12-01

    Full Text Available This article presents the relationship between the increase in the number of lynching in Brazil and the omission of state to comply with its duty to punish and reintegrate of offenders into community. It is explained the origins and causes of the phenomenon and its use as a form of exhibitionism punishment. Additionally, it is showed how the state inaction in combating crime allows the occurrence of private punishment and encourages its practice. It is exposed the relationship between this lethargy and the growth in crime rates which creates a cycle of violence. It is used literature review as a research methodology and it is analyzed fundamental rights and constitutional guarantees and the intolerable disrespect in relation to the case of lynched people. It is indicated that these offenses are the main reason to start an effective combat against the practice of lynching. It is justified why government needs to work together with civil society in pursuing an effective security policies and investments to combat factors that cause violence in Brazil and the mechanisms to avoid these criminal offenses.

  18. Geochemical and geophysical examination of submarine groundwater discharge and associated nutrient loading estimates into Lynch Cove, Hood Canal, WA

    Science.gov (United States)

    Swarzenski, P.W.; Simonds, F.W.; Paulson, A.J.; Kruse, S.; Reich, C.

    2007-01-01

    Geochemical tracer data (i.e., 222Rn and four naturally occurring Ra isotopes), electromagnetic (EM) seepage meter results, and high-resolution, stationary electrical resistivity images were used to examine the bi-directional (i.e., submarine groundwater discharge and recharge) exchange of a coastal aquifer with seawater. Our study site for these experiments was Lynch Cove, the terminus of Hood Canal, WA, where fjord-like conditions dramatically limit water column circulation that can lead to recurring summer-time hypoxic events. In such a system a precise nutrient budget may be particularly sensitive to groundwater-derived nutrient loading. Shore-perpendicular time-series subsurface resistivity profiles show clear, decimeter-scale tidal modulation of the coastal aquifer in response to large, regional hydraulic gradients, hydrologically transmissive glacial terrain, and large (4-5 m) tidal amplitudes. A 5-day 222Rn time-series shows a strong inverse covariance between 222Rn activities (0.5−29 dpm L-1) and water level fluctuations, and provides compelling evidence for tidally modulated exchange of groundwater across the sediment/water interface. Mean Rn-derived submarine groundwater discharge (SGD) rates of 85 ± 84 cm d-1 agree closely in the timing and magnitude with EM seepage meter results that showed discharge during low tide and recharge during high tide events. To evaluate the importance of fresh versus saline SGD, Rn-derived SGD rates (as a proxy of total SGD) were compared to excess 226Ra-derived SGD rates (as a proxy for the saline contribution of SGD). The calculated SGD rates, which include a significant (>80%) component of recycled seawater, are used to estimate associated nutrient (NH4+, Si, PO43-, NO3 + NO2, TDN) loads to Lynch Cove. The dissolved inorganic nitrogen (DIN = NH4 + NO2 + NO3) SGD loading estimate of 5.9 × 104 mol d-1 is 1−2 orders of magnitude larger than similar estimates derived from atmospheric deposition and surface water runoff

  19. Geochemical and geophysical examination of submarine groundwater discharge and associated nutrient loading estimates into Lynch Cove, Hood Canal, WA.

    Science.gov (United States)

    Swarzenski, Peter W; Simonds, F William; Paulson, Anthony J; Kruse, Sarah; Reich, Chris

    2007-10-15

    Geochemical tracer data (i.e., 222Rn and four naturally occurring Ra isotopes), electromagnetic (EM) seepage meter results, and high-resolution, stationary electrical resistivity images were used to examine the bi-directional (i.e., submarine groundwater discharge and recharge) exchange of a coastal aquifer with seawater. Our study site for these experiments was Lynch Cove, the terminus of Hood Canal, WA, where fjord-like conditions dramatically limit water column circulation that can lead to recurring summer-time hypoxic events. In such a system a precise nutrient budget may be particularly sensitive to groundwater-derived nutrient loading. Shore-perpendicular time-series subsurface resistivity profiles show clear, decimeter-scale tidal modulation of the coastal aquifer in response to large, regional hydraulic gradients, hydrologically transmissive glacial terrain, and large (4-5 m) tidal amplitudes. A 5-day 222Rn time-series shows a strong inverse covariance between 222Rn activities (0.5-29 dpm L(-1)) and water level fluctuations, and provides compelling evidence for tidally modulated exchange of groundwater across the sediment/water interface. Mean Rn-derived submarine groundwater discharge (SGD) rates of 85 +/- 84 cm d(-1) agree closely in the timing and magnitude with EM seepage meter results that showed discharge during low tide and recharge during high tide events. To evaluate the importance of fresh versus saline SGD, Rn-derived SGD rates (as a proxy of total SGD) were compared to excess 226Ra-derived SGD rates (as a proxy for the saline contribution of SGD). The calculated SGD rates, which include a significant (>80%) component of recycled seawater, are used to estimate associated nutrient (NH4+, Si, PO4(3-), NO3 + NO2, TDN) loads to Lynch Cove. The dissolved inorganic nitrogen (DIN = NH4 + NO2 + NO3) SGD loading estimate of 5.9 x 10(4) mol d(-1) is 1-2 orders of magnitude larger than similar estimates derived from atmospheric deposition and surface water

  20. Linchamientos y conflicto político en Los Andes Lynchings and Political conflict in The Andes

    Directory of Open Access Journals (Sweden)

    Carlos M. Vilas

    2007-06-01

    Full Text Available En 2004, los alcaldes de dos municipalidades de la región aimara de los Andes fueron linchados en la aparente culminación de agudos conflictos políticos internos y entre las respectivas comunidades y el Estado central. En este artículo se discuten ambos casos con el fin de ilustrar las transformaciones experimentadas en años recientes en la organización y la dinámica interna de las comunidades andinas, y de la articulación conflictiva de la política local en los procesos e instituciones de más amplio alcance. Precariedad social e incapacidad o renuencia del Estado para responder con eficacia a demandas básicas de determinados grupos de población configuran enmarcamientos socioeconómicos e institucionales de los linchamientos. En contraste con enfoques que enfatizan en factores culturales tradicionales o en un supuesto nacionalismo indígena, en el artículo se destaca la gravitación de fenómenos y procesos político- institucionales recientes en la transformación cultural y política de las comunidades, en el modo en que éstas procesan sus conflictos internos y con el Estado central.In 2004, two municipalitys mayors form the aimara Andes of Peru and Bolivia were subjected to mass lynchings as a result of the apparent culmination of violent political confrontations. This paper deals with these events as dramatic illustrations of the transformations the Andean communities experienced during recent decades in their internal dynamics, as well as in the articulation of local politics to processes and institutions beyond the communal limits. Structural precariousness combined with the state's inability or reluctance to come to terms with social or political demands from relevant segments of the people in the communities set the socioeconomic and institutional stage for lynchings. In contrast with approaches relating these events to an alleged indigenous cultural identity, the analysis points to the impact of the communities' political

  1. Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic

    Institute of Scientific and Technical Information of China (English)

    Patrícia Koehler-Santos; Mario Antonello Rosito; Patricia Ashton-Prolla; Jo(a)o Carlos Prolla; Patricia Izetti; Jamile Abud; Carlos Eduardo Pitroski; Silvia Liliana Cossio; Suzi Alves Camey; Cláudio Tarta; Daniel C Damin; Paulo Carvalho Contu

    2011-01-01

    AIM: To determine the prevalence of a family history suggestive of Lynch syndrome (LS) among patients with colorectal cancer (CRC) followed in a coloproctology outpatient clinic in Southern Brazil.METHODS: A consecutive sample of patients with CRC were interviewed regarding personal and family histories of cancer. Clinical data and pathology features of the tumor were obtained from chart review.RESULTS: Of the 212 CRC patients recruited, 61 (29%)reported a family history of CRC, 45 (21.2%) were diagnosed under age 50 years and 11 (5.2%) had more than one primary CRC. Family histories consistent with Amsterdam and revised Bethesda criteria for LS were identified in 22 (10.4%) and 100 (47.2%) patients,respectively. Twenty percent of the colorectal tumors had features of the high microsatellite instability phenotype,which was associated with younger age at CRC diagnosis and with Bethesda criteria (P < 0.001). Only 5.3% of the patients above age 50 years had been previously submitted for CRC screening and only 4% of patients with suspected LS were referred for genetic risk assessment.CONCLUSION: A significant proportion of patients with CRC were at high risk for LS. Education and training of health care professionals are essential to ensure proper management.

  2. Bayesian Modeling for Genetic Anticipation in Presence of Mutational Heterogeneity: A Case-Study in Lynch Syndrome

    Science.gov (United States)

    Boonstra, Philip S.; Mukherjee, Bhramar; Taylor, Jeremy M. G.; Nilbert, Mef; Moreno, Victor M.; Gruber, Stephen B.

    2011-01-01

    Summary Genetic anticipation, described by earlier age of onset (AOO) and more aggressive symptoms in successive generations, is a phenomenon noted in certain hereditary diseases. Its extent may vary between families and/or between mutation sub-types known to be associated with the disease phenotype. In this paper, we posit a Bayesian approach to infer genetic anticipation under flexible random effects models for censored data that capture the effect of successive generations on AOO. Primary interest lies in the random effects. Misspecifying the distribution of random effects may result in incorrect inferential conclusions. We compare the fit of four candidate random effects distributions via Bayesian model fit diagnostics. A related statistical issue here is isolating the confounding effect of changes in secular trends, screening and medical practices that may affect time to disease detection across birth cohorts. Using historic cancer registry data, we borrow from relative survival analysis methods to adjust for changes in age-specific incidence across birth cohorts. Our motivating case-study comes from a Danish cancer register of 124 families with mutations in mismatch repair genes known to cause hereditary non-polyposis colorectal cancer, also called Lynch syndrome. We find evidence for a decrease in AOO between generations in this study. Our model predicts family level anticipation effects which are potentially useful in genetic counseling clinics for high risk families. PMID:21627626

  3. Functional testing strategy for coding genetic variants of unclear significance in MLH1 in Lynch syndrome diagnosis.

    Science.gov (United States)

    Hinrichsen, Inga; Schäfer, Dieter; Langer, Deborah; Köger, Nicole; Wittmann, Margarethe; Aretz, Stefan; Steinke, Verena; Holzapfel, Stefanie; Trojan, Jörg; König, Rainer; Zeuzem, Stefan; Brieger, Angela; Plotz, Guido

    2015-02-01

    Lynch syndrome is caused by inactivating mutations in the MLH1 gene, but genetic variants of unclear significance frequently preclude diagnosis. Functional testing can reveal variant-conferred defects in gene or protein function. Based on functional defect frequencies and clinical applicability of test systems, we developed a functional testing strategy aimed at efficiently detecting pathogenic defects in coding MLH1 variants. In this strategy, tests of repair activity and expression are prioritized over analyses of subcellular protein localization and messenger RNA (mRNA) formation. This strategy was used for four unclear coding MLH1 variants (p.Asp41His, p.Leu507Phe, p.Gln689Arg, p.Glu605del + p.Val716Met). Expression was analyzed using a transfection system, mismatch repair (MMR) activity by complementation in vitro, mRNA formation by reverse transcriptase-PCR in carrier lymphocyte mRNA, and subcellular localization with dye-labeled fusion constructs. All tests included clinically meaningful controls. The strategy enabled efficient identification of defects in two unclear variants: the p.Asp41His variant showed loss of MMR activity, whereas the compound variant p.Glu605del + p.Val716Met had a defect of expression. This expression defect was significantly stronger than the pathogenic expression reference variant analyzed in parallel, therefore the defect of the compound variant is also pathogenic. Interestingly, the expression defect was caused additively by both of the compound variants, at least one of which is non-pathogenic when occurring by itself. Tests were neutral for p.Leu507Phe and p.Gln689Arg, and the results were consistent with available clinical data. We finally discuss the improved sensitivity and efficiency of the applied strategy and its limitations in analyzing unclear coding MLH1 variants.

  4. Hereditary diffuse gastric cancer and lynch syndromes in a BRCA1/2 negative breast cancer patient.

    Science.gov (United States)

    Njoroge, Scolastica W; Burgess, Kelly R; Cobleigh, Melody A; Alnajar, Hussein H; Gattuso, Paolo; Usha, Lydia

    2017-07-12

    Genetic counseling and testing is recommended for women with a personal and/or family history of breast and other cancers (ovarian, pancreatic, male breast and others). Mutations in the BRCA1 and BRCA2 genes (BRCA1/2) are the most common causes of hereditary breast and ovarian cancer. Additional genetic counseling and testing with a multi-gene panel may be considered in breast cancer patients who tested negative for mutations in these two genes. In about 11% of BRCA1/2-negative patients, further genetic testing reveals pathogenic mutations in other high or moderate cancer risk genes. In 0.2% of cases, an individual may carry pathogenic mutations in more than one high penetrance gene (a double heterozygote). Finding one or more pathogenic mutations is important for cancer prevention in patients and/or their families. Here we present a case of a breast cancer patient who did not have a pathogenic mutation in BRCA1/2 and had a family history of breast and stomach cancers. On an additional multi-gene panel testing, she was found to carry pathogenic mutations in the CDH1 and PMS2 genes, which cause Hereditary Diffuse Gastric Cancer and Lynch syndromes, respectively. To our knowledge, this is the first description of such a double heterozygote. Clinical manifestations, genetics, and management of both syndromes are reviewed, including prophylactic surgery and screening for unaffected family members. Management challenges for a mutation carrier with advanced breast cancer are discussed. Our case supports the clinical utility of additional multi-gene panel testing for breast cancer patients who do not have a pathogenic mutation in BRCA1/2 genes.

  5. Psychological distress in newly diagnosed colorectal cancer patients following microsatellite instability testing for Lynch syndrome on the pathologist's initiative.

    Science.gov (United States)

    Landsbergen, K M; Prins, J B; Brunner, H G; van Duijvendijk, P; Nagengast, F M; van Krieken, J H; Ligtenberg, M; Hoogerbrugge, N

    2012-06-01

    According to the Dutch Guideline on Hereditary Colorectal Cancer published in 2008, patients with recently diagnosed colorectal cancer (CRC) should undergo microsatellite instability (MSI) testing by a pathologist immediately after tumour resection if they are younger than 50 years, or if a second CRC has been diagnosed before the age of 70 years, owing to the high risk of Lynch syndrome (MIPA). The aim of the present MIPAPS study was to investigate general distress and cancer-specific distress following MSI testing. From March 2007 to September 2009, 400 patients who had been tested for MSI after newly diagnosed CRC were recruited from 30 Dutch hospitals. Levels of general distress (SCL-90) and cancer-specific distress (IES) were assessed immediately after MSI result disclosure (T1) and 6 months later (T2). Response rates were 23/77 (30%) in the MSI-positive patients and 58/323 (18%) in the MSI-negative patients. Levels of general distress and cancer-specific distress were moderate. In the MSI-positive group, 27% of the patients had high general distress at T1 versus 18% at T2 (p = 0.5), whereas in the MSI-negative group, these percentage were 14 and 18% (p = 0.6), respectively. At T1 and T2, cancer-specific distress rates in the MSI-positive group and MSI-negative group were 39 versus 27% (p = 0.3) and 38 versus 36% (p = 1.0), respectively. High levels of general distress were correlated with female gender, low social support and high perceived cancer risk. Moderate levels of distress were observed after MSI testing, similar to those found in other patients diagnosed with CRC. Immediately after result disclosure, high cancer-specific distress was observed in 40% of the MSI-positive patients.

  6. Genetic testing for Lynch syndrome in the first year of colorectal cancer: a review of the psychological impact.

    Science.gov (United States)

    Landsbergen, Karin M; Prins, Judith B; Brunner, Han G; Kraaimaat, Floris W; Hoogerbrugge, Nicoline

    2009-01-01

    An increasing number of patients with colorectal cancer (CRC) receive genetic counselling within 1 year after diagnosis. Little is known whether specific subgroups are more vulnerable for genetic testing related distress. A literature review was conducted to identify the psychological impact of CRC in the first year, and the additional impact of genetic testing. The electronic databases of PubMed, PsychInfo, Embase and the Cochrane Library were searched to identify all reports published between January 1997 and October 2007 on the psychological impact of (1) CRC-diagnosis up to 1 year after treatment and of (2) genetic testing for Lynch syndrome in patients with CRC. Studies on the psychological impact of genetic testing in newly diagnosed patient with CRC were not available. Either CRC patients diagnosed several years ago were studied and the focus was also often on the psychological impact of genetic testing prior to DNA-test disclosure. They show that limitations in emotional and social functioning can persist up to 1 year after CRC treatment, especially in those with a stoma or diagnosed before age 60. Female patients and male patients diagnosed before age 50 appear to be more vulnerable to genetic test-related distress. It is well known that being treated for CRC has great impact on psychological functioning. Little is known about the psychological impact during the first year after diagnosis and very little is known about the additional psychological effect of genetic testing for hereditary cancer in this period. We found presumptive evidence that specific subgroups of patients with CRC are more vulnerable for genetic-testing-related distress.

  7. Supplement Analysis for the Transmission System Vegetation Management Program FEIS (DOE/EIS-0285/SA-104–Lynch Creek Tap to LaGrande-Cowlitz No. 1

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Mark A. [Bonneville Power Administration (BPA), Portland, OR (United States)

    2002-08-21

    Vegetation Management for the Lynch Creek to LaGrande-Cowlitz No. 1. BPA proposes to remove unwanted vegetation along the right-of-way, access roads and around tower structures along the subject transmission line corridor. The right-of-way will be treated using selective and non-selective methods that include hand cutting, mowing and herbicide treatments. Approximately 29 miles of access roads and corridor will be treated. Vegetation management is required for unimpeded operation and maintenance of the subject transmission line. See Section 1 of the attached checklist for a complete description of the proposal.

  8. De onde se vê? Duplicação e dissolução do olhar em Alfred Hitchcock e David Lynch

    Directory of Open Access Journals (Sweden)

    Ulysses Pinheiro

    2015-07-01

    Full Text Available Este artigo compara dois filmes, Janela indiscreta, de Alfred Hitchcock, e Estrada perdida, de David Lynch, com o objetivo de mostrar que eles ilustram duas maneiras distintas de caracterizar o olhar inumano da percepção cinematográfica, tal como ele foi descrito por Gilles Deleuze. Essas duas maneiras distintas não foram discriminadas pelo próprio Deleuze, mas convergem em direção a sua crítica à hermenêutica.

  9. 55,000 yrs of Environmental Change in the Southern Hemisphere: Peat Stratigraphy and Inorganic Geochemistry of Lynch's Crater, NE Queensland, Australia.

    Science.gov (United States)

    Muller, J.; Kylander, M. E.; Wust, R. A.; Weiss, D. J.

    2005-12-01

    This study presents one of the first applications of geochemical proxies to define changes in vegetation, hydrology and atmospheric dust recorded in a peat deposit in the Southern Hemisphere. The Lynch's Crater archive has captured local, regional and global environmental changes and reveals dynamic ecosystem changes as a result of climate shifts over the past 55,000 yrs BP. The 13 m peat record consists of 1.5 m of ombrotrophic peat underlain by a minerotrophic peat. The ombrotrophic section consists of low inorganic content ("ash") and low pH, as expected in of an ombrotrophic environment. The minerotrophic section contains several layers, up to a few cm thick, where abundant sponge spicules, diatom fragments and detrital quartz are indicative of high algal and protista productivity. These layers are characterised by high (up to 50%) ash, indicating persistent flooding of the peat deposits of Lynch's Crater and signalling periods of change in precipitation in North Queensland, Australia. Geochemical data are used to differentiate between climatic episodes associated with flooding events and internal and external atmospheric dust fluxes. Lead isotopes with lithogenic and chalcophile elements tell us that two distinctive sources are prevalent in the Lynch's Crater record. Most of the inorganic fractions of the deposits have the same geochemical signatures as the rocks and sediments of the crater wall, with low As concentrations, high Al, Ti and Sc concentrations and a more radiogenic Pb isotope signature. Influence from long-range dust is distinguished in the lower sections of the core (~35,000-55,000 cal yrs BP) where increases in As concentrations and less radiogenic Pb isotopes are found. Leading up to the Holocene (~35,000-10,000) the influence of increased dust influx becomes more significant (increasing lithogenics, chalcophiles and ash content) and where possible long-range sources are still active, but diluted by a prevailing dominance of the local sources

  10. A putative Lynch syndrome family carrying MSH2 and MSH6 variants of uncertain significance-functional analysis reveals the pathogenic one

    DEFF Research Database (Denmark)

    Kantelinen, Jukka; Hansen, Thomas V O; Kansikas, Minttu;

    2011-01-01

    Inherited pathogenic mutations in the mismatch repair (MMR) genes, MSH2, MLH1, MSH6, and PMS2 predispose to Lynch syndrome (LS). However, the finding of a variant or variants of uncertain significance (VUS) in affected family members complicates the risk assessment. Here, we describe a putative L...... identified VUS before predictive gene testing and genetic counseling are offered to a family.......Inherited pathogenic mutations in the mismatch repair (MMR) genes, MSH2, MLH1, MSH6, and PMS2 predispose to Lynch syndrome (LS). However, the finding of a variant or variants of uncertain significance (VUS) in affected family members complicates the risk assessment. Here, we describe a putative LS...... family carrying VUS in both MSH2 (c.2768T>A, p.Val923Glu) and MSH6 (c.3563G>A, p.Ser1188Asn). Two colorectal cancer (CRC) patients were studied for mutations and identified as carriers of both variants. In spite of a relatively high mean age of cancer onset (59.5 years) in the family, many CRC patients...

  11. 改良 B-Lynch 缝合术在剖宫产术中宫缩乏力性出血的应用%Application of improved B-Lynch sutura in hemorrhage caused by uterine inertia during the ce-sarean section

    Institute of Scientific and Technical Information of China (English)

    白琳

    2014-01-01

    Objective To investigate the application methods and clinical effect of improved B-Lynch sutura on hemorrhage caused by uterine inertia during the cesarean section. Methods A retro-spective analysis was performed on the clinical data of 72 patients with hemorrhage caused by uterine in-ertia during the cesarean section,who were treated by improved B-Lynch sutura in the first people’s hos-pital of Shangqiu from April 2008 to June 2013. Results The hemorrhage dosage during operation of the 72 patients was 600 - 2300 ml,all of the patients were stanched effectively,the effective rate was 100%and there was no hemorrhagic shock occured during the operation,7 cases were taken transfusion for 400 - 800 ml,no one was cut the uterus because of hemorrhage out-of-control. The uterus wounds of the patients healed well and there was no complication of rehaemorrhagia,infection,intrauterine adhesion or endometriosis occur. Follow-up visited for 7 - 14 months after the patients left the hospital,found their lochia was regular,when reviewed the patients by B ultrasound 42 days after the operation showed that, their involution of uterus was good. Conclusions The B-Lynch sutura is easy to handle,dispense with special instrument and high technical requirements,it has the characteristics of rapid,valid and definite when salvaging the patients with massive haemorrhage caused by uterine inertia during the cesarean sec-tion,besides,it is also beneficial to uterus recovery and suitable for primary hospital to use.%目的:探讨改良 B-Lynch 缝扎术治疗剖宫产术中宫缩乏力性产后出血的应用方法及临床效果。方法回顾性分析2008年4月至2013年6月间商丘市第一人民医院采用改良式 B-Lynch 缝合术治疗的72例剖宫产术中宫缩乏力性产后出血患者的临床资料。结果72例患者术中出血600~2300 ml,均有效止血,有效率100%,无术中失血性休克发生,7例患者输血400~800 ml,无因出血无法控制行子宫

  12. Truncation of the MSH2 C-terminal 60 amino acids disrupts effective DNA mismatch repair and is causative for Lynch syndrome.

    Science.gov (United States)

    Wielders, Eva; Delzenne-Goette, Elly; Dekker, Rob; van der Valk, Martin; Te Riele, Hein

    2017-04-01

    Missense variants of DNA mismatch repair (MMR) genes pose a problem in clinical genetics as long as they cannot unambiguously be assigned as the cause of Lynch syndrome (LS). To study such variants of uncertain clinical significance, we have developed a functional assay based on direct measurement of MMR activity in mouse embryonic stem cells expressing mutant protein from the endogenous alleles. We have applied this protocol to a specific truncation mutant of MSH2 that removes 60 C-terminal amino acids and has been found in suspected LS families. We show that the stability of the MSH2/MSH6 heterodimer is severely perturbed, causing attenuated MMR in in vitro assays and cancer predisposition in mice. This mutation can therefore unambiguously be considered as deleterious and causative for LS.

  13. Tumour spectrum of non-polyposis colorectal cancer (Lynch syndrome) on the island of Tenerife and influence of insularity on the clinical manifestations.

    Science.gov (United States)

    Medina-Arana, V; Barrios, Y; Fernández-Peralta, A; Jiménez, A; Salido, E; González, F; González-Aguilera, J J

    2004-02-01

    Colorectal cancer is a complex disease from a genetic point of view because both genetic and environmental factors interact in its development. Only familial adenomatous polyposis (FAP) follows mendelian genetics, in that mutations of the APC gene lead to development of the tumours. Lynch syndrome is the most frequent form of hereditary colorectal cancer and appears to be associated with other types of extracolonic cancers. The genetic basis has been established as a defect in DNA mismatch repair genes, and there is genetic heterogeneity due to the involvement of several genes in this system. Germinal mutations in these genes predispose to appearance of the syndrome. The aim of this study is to describe the tumoral spectrum of 10 families, comprising a total of 488 individuals, from the island of Tenerife (Canary Islands) and to assess whether the geographical isolation of this population has changed any features of the tumoral spectrum of the syndrome in comparison with studies that cover larger geographical areas with more genetic exchange. From our results we can conclude that the genetic drift and consanguinity in this population with a demographic history of isolation did not significantly alter the tumoral spectrum of the syndrome. Our data confirm that families affected by Lynch syndrome are a high-risk population and should be closely monitored, since their careful supervision has been shown to be useful in preventing cancer. We also emphasize the importance of developing a complete family history that permits these families to be identified together with a mutational screening of DNA mismatch repair genes (mainly MLH1 and MSH2 genes) with the aim of a possible identification of members of a family that should be carefully monitored (the carriers of germline mutations in these genes), whereas the remaining members, originally, are no more at risk than the general population.

  14. David Lynch - Dark Splendor. Raum Bilder Klang, hrg. von Werner Spies, Ostfildern 2009; See this Sound. Versprechungen von Bild und Ton, hrg. von Cosima Rainer u.a., Köln 2009

    Directory of Open Access Journals (Sweden)

    Sarah Mauksch

    2010-09-01

    Full Text Available Das Max Ernst Museum in Brühl und das Lentos Kunstmuseum in Linz haben jüngst zwei Ausstellungskataloge herausgebracht, denen eine jeweils bemerkenswerte Ausstellung vorausging.Der Regisseur David Lynch wurde vor allem durch seine beeindruckenden Spielfilme wie Lost Highway, Mulholland Drive, Blue Velvet oder durch die Serie Twin Peaks aus den 90er Jahren bekannt. Die Ausstellung David Lynch – Dark Splendor. Raum Bilder Klang enthüllt eine Seite des Kultregisseurs, die vielen Filmliebhabern noch unentdeckt geblieben sein könnte. Brühl zeigt hier erstmals in Deutschland eine Sammlung, die sich nur mit dem bildnerischen Schaffen des Künstlers befasst.

  15. Evaluating the performance of clinical criteria for predicting mismatch repair gene mutations in Lynch syndrome: a comprehensive analysis of 3,671 families.

    Science.gov (United States)

    Steinke, Verena; Holzapfel, Stefanie; Loeffler, Markus; Holinski-Feder, Elke; Morak, Monika; Schackert, Hans K; Görgens, Heike; Pox, Christian; Royer-Pokora, Brigitte; von Knebel-Doeberitz, Magnus; Büttner, Reinhard; Propping, Peter; Engel, Christoph

    2014-07-01

    Carriers of mismatch repair (MMR) gene mutations have a high lifetime risk for colorectal and endometrial cancers, as well as other malignancies. As mutation analysis to detect these patients is expensive and time-consuming, clinical criteria and tumor-tissue analysis are widely used as pre-screening methods. The aim of our study was to evaluate the performance of commonly applied clinical criteria (the Amsterdam I and II Criteria, and the original and revised Bethesda Guidelines) and the results of tumor-tissue analysis in predicting MMR gene mutations. We analyzed 3,671 families from the German HNPCC Registry and divided them into nine mutually exclusive groups with different clinical criteria. A total of 680 families (18.5%) were found to have a pathogenic MMR gene mutation. Among all 1,284 families with microsatellite instability-high (MSI-H) colorectal cancer, the overall mutation detection rate was 53.0%. Mutation frequencies and their distribution between the four MMR genes differed significantly between clinical groups (p small-bowel cancer (p small-bowel cancer were clinically relevant predictors for Lynch syndrome. © 2013 UICC.

  16. A Review of James Lynch Multicultural Education Ideology%詹姆斯·林奇多元文化教育思想及评析

    Institute of Scientific and Technical Information of China (English)

    廖明艳

    2016-01-01

    当今世界各国都面临多元文化的冲击,各国教育工作者也不遗余力地进行着多元文化教育的研究,詹姆斯·林奇在这一方面做出了自己的贡献。他的多元文化教育思想主要体现在其多元文化课程理论及全球多元文化教育思想之中,其最大特点是从全球化的观点审视多元文化教育。%Today ,all countries in the world are being affected by multi-cultures ,the educators all over the world have spared no effort to study the multicultural education .James Lynch has made his own contribution to this aspect .His multicultural education ideology reflects on his multicultural curriculum theory ,the thought of global multicultural education and the civic education .And its characteristic is that he examines the multicultural education from the perspective of globalization .

  17. Experience of B-Lynch suture in 8 cases of postpartum hemorrhage%B -Lynch缝合术治疗8例剖宫产后出血体会

    Institute of Scientific and Technical Information of China (English)

    杨春霞

    2015-01-01

    Objective To investigate the clinical effect of B-Lynch suture in the treatment of postpartum hemorrhage.Methods The data of medical records of 8 patients with postpartum hemorrhage treated by B-Lynch suture were retrospectively analyzed in our hospital from January 2012 to 2015 March.Results Totally 8 cases of patients were successful hemostasis, uterus preserved, no 1 case reoperation or hys-terectomy because of poor blood circulation or rebleeding, no related complications occurred, involution of uterus, menstruation time without ex-ception.Conclusion B-Lynch suture is an effective surgical hemostasis method for the treatment of cesarean section uterine bleeding caused by uterine contraction fatigae, and is simple and feasible, especially for the basic hospital.%目的:探讨B-Lynch缝合术治疗剖宫产后出血的效果。方法对8例剖宫产后出血患者采用B-Lynch缝合术治疗,回顾性分析患者的病历资料。结果8例患者均经B-Lynch缝合术成功止血,无1例因血液循环不良或再出血手术或子宫切除。子宫复旧、月经复潮时间无异常。结论剖宫产后子宫收缩乏力性出血药物治疗无效时,B-Lynch缝合术操作简单易行,止血效果可靠,尤其适合在基层医院开展。

  18. Population-Based Lynch Syndrome Screening by Microsatellite Instability in Patients ≤50: Prevalence, Testing Determinants, and Result Availability Prior to Colon Surgery.

    Science.gov (United States)

    Karlitz, Jordan J; Hsieh, Mei-Chin; Liu, Yong; Blanton, Christine; Schmidt, Beth; Jessup, J Milburn; Wu, Xiao-Cheng; Chen, Vivien W

    2015-07-01

    As there are no US population-based studies examining Lynch syndrome (LS) screening frequency by microsatellite instability (MSI) and immunohistochemistry (IHC), we seek to quantitate statewide rates in patients aged ≤50 years using data from a Centers for Disease Control and Prevention-funded Comparative Effectiveness Research (CER) project and identify factors associated with testing. Screening rates in this young, high-risk population may provide a best-case scenario as older patients, potentially deemed lower risk, may undergo testing less frequently. We also seek to determine how frequently MSI/IHC results are available preoperatively, as this may assist with decisions regarding colonic resection extent. Data from all Louisiana colorectal cancer (CRC) patients aged ≤50 years diagnosed in 2011 were obtained from the Louisiana Tumor Registry CER project. Registry researchers and physicians analyzed data, including pathology and MSI/IHC. Of the 2,427 statewide all-age CRC patients, there were 274 patients aged ≤50 years, representing health care at 61 distinct facilities. MSI and/or IHC were performed in 23.0% of patients. Testing-associated factors included CRC family history (Plocation (P<0.0370), and care at comprehensive cancer centers (P<0.0020) but not synchronous/metachronous CRC or MSI-like histology. Public hospital screening was disproportionately low (P<0.0217). Of those tested, MSI and/or IHC was abnormal in 21.7%. Of those with abnormal IHC, staining patterns were consistent with LS in 87.5%. MSI/IHC results were available preoperatively in 16.9% of cases. Despite frequently abnormal MSI/IHC results, LS screening in young, high-risk patients is low. Provider education and disparities in access to specialized services, particularly in underserved populations, are possible contributors. MSI/IHC results are infrequently available preoperatively.

  19. A morphological, isoenzymatic and behavioural study of ten populations of Anopheles(Nyssorhynchus albitarsis Lynch-Arribalzaga, 1878 (Diptera: culicidae including from the type-locality - Baradero, Argentina

    Directory of Open Access Journals (Sweden)

    Maria Goreti Rosa-Freitas

    1990-09-01

    Full Text Available Anopheles (Nyssorhynchus albitarsis Lynch-Arribalzaga, 1878 shows morphological and behavioural variations which results in it being sometimes considered as a major malaria vector and at other times as playing no important role in epidemiology. With the aim of clarifying the taxonomy of the species, comparative morphological and isoenzymatic studies were made in populations from the type-locality, Baradero, Argentina and from 9 different localities inBrazil. Morphological studies consisted of the observation of eggs in scanning electron microscopy, of complete chaetotaxy of larvae and pupae and of the detailed drawing of male and female adults. Only Guajara-Mirim and Rio Branco populations, described previously as Anopheles deaneorum sp.n., showed morphological differences. Isoenzymes were studied using 4th instar larvae homogenate and agarosegel electrophoresis. Eleven enzymatic loci were analyzed. By calculation of Nei's Genetic Distance (D, the populations could be separated into 5 groups: iBaradero, iiMarajo, iiiBoa Vista, ivAngra, Itaguai and Paraipaba and vGuajara-Mirim and Rio Branco. These groups belong to 2 major clusters called I and II, separated by D = 0.345. In the I cluster are groups i, ii and iii and in II clusteriv and v. In I, D=0.246 separates i and ii from iii, while i is separated by D =0.181 from ii. In II, D = 0.223 between iv and v. Only the population of group vcould be distinguished morphologically from the others, leading to the description of an independent species An. deaneorum.

  20. Lynch syndrome-associated colorectal carcinoma: frequent involvement of the left colon and rectum and late-onset presentation supports a universal screening approach.

    Science.gov (United States)

    Hartman, Douglas J; Brand, Randall E; Hu, Huankai; Bahary, Nathan; Dudley, Beth; Chiosea, Simon I; Nikiforova, Marina N; Pai, Reetesh K

    2013-11-01

    The optimal strategy for screening patients with colorectal carcinoma for Lynch syndrome (LS) is a subject of continued debate in the literature with some advocating universal screening while others arguing for selective screening. We evaluated 1292 colorectal carcinomas for DNA mismatch repair protein abnormalities and identified 150 (11.6%) tumors demonstrating high-levels of microsatellite instability (MSI-H). MSI-H colorectal carcinomas were divided into sporadic (112/1292, 8.7%) and LS/probable LS-associated (38/1292, 2.9%) groups based on BRAF V600E mutation, MLH1 promoter hypermethylation, cancer history, and germline mismatch repair gene mutation. All MSI-H colorectal carcinomas were analyzed for grade, location, and tumor histology. The utility of the revised Bethesda guidelines and published predictive pathology models for MSI-H colorectal carcinomas (PREDICT and MSPath) were evaluated. Left-sided MSI-H colorectal carcinomas were more frequently associated with LS compared with right-sided MSI-H colorectal carcinomas (12/21, 57% versus 26/129, 20%, P = .0008). There was no significant difference in histology between sporadic MSI-H and LS/probable LS-associated colorectal carcinomas except for a slightly higher proportion of sporadic MSI-H tumors demonstrating tumor-infiltrating lymphocytes (81% versus 61%, P = .015). Neither pathology predictive model identified all LS-associated colorectal carcinomas (PREDICT: 33/38, 87%; MSPath: 35/38, 92%). 12/117 (10%) MSI-H colorectal carcinomas identified in patients >60 years were LS/probable LS-associated. Our results demonstrate that models of predicting MSI-H fail to identify LS-associated colorectal carcinoma given their reliance on right-sided location. A significant proportion (32%) of LS-associated colorectal carcinoma is identified in patients >60 years. Finally, our results demonstrate similar morphologic features between LS-associated and sporadic MSI-H colorectal carcinomas.

  1. Isolated Loss of PMS2 Immunohistochemical Expression is Frequently Caused by Heterogenous MLH1 Promoter Hypermethylation in Lynch Syndrome Screening for Endometrial Cancer Patients.

    Science.gov (United States)

    Kato, Aya; Sato, Naoki; Sugawara, Tae; Takahashi, Kazue; Kito, Masahiko; Makino, Kenichi; Sato, Toshiharu; Shimizu, Dai; Shirasawa, Hiromistu; Miura, Hiroshi; Sato, Wataru; Kumazawa, Yukiyo; Sato, Akira; Kumagai, Jin; Terada, Yukihiro

    2016-06-01

    Lynch syndrome (LS) is an autosomal-dominant inherited disorder mainly caused by a germline mutation in the DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6, and PMS2) and is associated with increased risk for various cancers, particularly colorectal cancer and endometrial cancer (EC). Women with LS account for 2% to 6% of EC patients; it is clinically important to identify LS in such individuals for predicting and/or preventing additional LS-associated cancers. PMS2 germline mutation (PMS2-LS) is the rarest contribution to LS etiology among the 4 LS-associated MMR germline mutations, and its detection is complicated. Therefore, prudent screening for PMS2-LS is important as it leads to an efficient LS identification strategy. Immunohistochemistry is recommended as a screening method for LS in EC. Isolated loss of PMS2 (IL-PMS2) expression is caused not only by PMS2-LS but also by MLH1 germline mutation or MLH1 promoter hypermethylation (MLH-PHM). This study aimed to determine the association between MLH1-PHM and IL-PMS2 to avoid inappropriate genetic analysis. We performed MLH1 methylation analysis and MLH1/PMS2 germline mutation testing on the IL-PMS2 cases. By performing MMR-immunohistochemistry on 360 unselected ECs, we could select 8 (2.2%) cases as IL-PMS2. Heterogenous MLH1 staining and MLH1-PHM were detected in 4 of 8 (50%) IL-PMS2 tumors. Of the 5 IL-PMS2 patients who underwent genetic analysis, 1 had PMS2 germline mutation with normal MLH1 expression (without MLH1-PHM), and no MLH1 germline mutation was detected. We suggest that MLH1 promoter methylation analysis for IL-PMS2 EC should be performed to exclude sporadic cases before further PMS2 genetic testing.

  2. Evidence for classification of c.1852_1853AA>GC in MLH1 as a neutral variant for Lynch syndrome

    Directory of Open Access Journals (Sweden)

    Llor Xavier

    2011-01-01

    Full Text Available Abstract Background Lynch syndrome (LS is an autosomal dominant inherited cancer syndrome characterized by early onset cancers of the colorectum, endometrium and other tumours. A significant proportion of DNA variants in LS patients are unclassified. Reports on the pathogenicity of the c.1852_1853AA>GC (p.Lys618Ala variant of the MLH1 gene are conflicting. In this study, we provide new evidence indicating that this variant has no significant implications for LS. Methods The following approach was used to assess the clinical significance of the p.Lys618Ala variant: frequency in a control population, case-control comparison, co-occurrence of the p.Lys618Ala variant with a pathogenic mutation, co-segregation with the disease and microsatellite instability in tumours from carriers of the variant. We genotyped p.Lys618Ala in 1034 individuals (373 sporadic colorectal cancer [CRC] patients, 250 index subjects from families suspected of having LS [revised Bethesda guidelines] and 411 controls. Three well-characterized LS families that fulfilled the Amsterdam II Criteria and consisted of members with the p.Lys618Ala variant were included to assess co-occurrence and co-segregation. A subset of colorectal tumour DNA samples from 17 patients carrying the p.Lys618Ala variant was screened for microsatellite instability using five mononucleotide markers. Results Twenty-seven individuals were heterozygous for the p.Lys618Ala variant; nine had sporadic CRC (2.41%, seven were suspected of having hereditary CRC (2.8% and 11 were controls (2.68%. There were no significant associations in the case-control and case-case studies. The p.Lys618Ala variant was co-existent with pathogenic mutations in two unrelated LS families. In one family, the allele distribution of the pathogenic and unclassified variant was in trans, in the other family the pathogenic variant was detected in the MSH6 gene and only the deleterious variant co-segregated with the disease in both

  3. ISOLDE PH team, from left to right: Jennifer Weterings (user support), Susanne Kreim (research fellow), Marek Pfützner (scientific associate), Maria Garcia Borge (team leader), Elisa Rapisarda (research fellow) , Magdalena Kowalska (physics coordinator), Jan Kurcewicz (applied fellow), Monika Stachura (applied fellow). Not in the photo: Kara Lynch (PhD student).

    CERN Multimedia

    Visual Media Office

    2013-01-01

    ISOLDE PH team, from left to right: Jennifer Weterings (user support), Susanne Kreim (research fellow), Marek Pfützner (scientific associate), Maria Garcia Borge (team leader), Elisa Rapisarda (research fellow) , Magdalena Kowalska (physics coordinator), Jan Kurcewicz (applied fellow), Monika Stachura (applied fellow). Not in the photo: Kara Lynch (PhD student).

  4. Genetics Home Reference: Lynch syndrome

    Science.gov (United States)

    ... in preparation for cell division (a process called DNA replication ). Mutations in any of these genes prevent the proper repair of DNA replication mistakes. As the abnormal cells continue to divide, ...

  5. Comment Hollywood figure l’intériorité dans les films « hollywoodiens » de David Lynch, Lost Highway (1997, Mulholland Dr. (2001 et Inland Empire (2006

    Directory of Open Access Journals (Sweden)

    David ROCHE

    2011-09-01

    Full Text Available L’article prend comme point de départ les travaux de Zachary Baqué et vise à montrer, à travers une étude diachronique, que les films hollywoodiens de Lynch ne le sont pas uniquement par leur représentation satirique d’un système corrompu qui compromet les ambitions qu’il suscite, ni même par la façon dont il retravaille les conventions génériques et narratives propres au cinéma hollywoodien. Hollywood est une présence à la fois horizontale et verticale, physique et abstraite, réelle et imaginaire, qui renvoie à la ville, au système, au cinéma et au rêve, si bien que la satire, la topographie, les motifs visuels parfois clichés et les références filmiques sont intimement liés en une expression de la subjectivité et de l’intérioritéThe article takes Zachary Baqué’s study of Los Angeles in the films of David Lynch as a starting point to explore David Lynch’s Hollywood movies. The author contends that the films offer more than a satirical representation of a corrupt, unhealthy system which threatens dreams and artistic creativity, or a parodic play on Hollywood genre and narrative conventions. Rather, Hollywood is a character, a presence, revealed as both horizontal and vertical, physical and abstract, evoking the city, the studio system, cinema and dreams, so that the satire, the visual motifs and clichés and the topography of Hollywood, and the references to Hollywood films, constitute a complex fabric of subjectivity and interiority.

  6. Identification of individuals at risk for Lynch syndrome using targeted evaluations and genetic testing: National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer joint practice guideline.

    Science.gov (United States)

    Weissman, Scott M; Burt, Randall; Church, James; Erdman, Steve; Hampel, Heather; Holter, Spring; Jasperson, Kory; Kalady, Matt F; Haidle, Joy Larsen; Lynch, Henry T; Palaniappan, Selvi; Wise, Paul E; Senter, Leigha

    2012-08-01

    Identifying individuals who have Lynch syndrome (LS) involves a complex diagnostic work up that includes taking a detailed family history and a combination of various genetic and immunohistochemical tests. The National Society of Genetic Counselors (NSGC) and the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA-ICC) have come together to publish this clinical practice testing guideline for the evaluation of LS. The purpose of this practice guideline is to provide guidance and a testing algorithm for LS as well as recommendations on when to offer testing. This guideline does not replace a consultation with a genetics professional. This guideline includes explanations in support of this and a summary of background data. While this guideline is not intended to serve as a review of LS, it includes a discussion of background information on LS, and cites a number of key publications which should be reviewed for a more in-depth understanding of LS. These guidelines are intended for genetic counselors, geneticists, gastroenterologists, surgeons, medical oncologists, obstetricians and gynecologists, nurses and other healthcare providers who evaluate patients for LS.

  7. 改良B-Lynch缝合联合宫腔填纱在剖宫产术中难治性出血中的应用%Application of modified B-Lynch suture combined with filling uterine cavity with gauze in intractable bleeding during cesarean section

    Institute of Scientific and Technical Information of China (English)

    胡莉琴; 章桂莲; 黄贤梅

    2012-01-01

    Objective o To explore the curative effect of modified B - Lynch suture combined with filling uterine cavity with gauze in intractable bleeding during cesarean section. Methods: Eighteen patients who were found with intractable bleeding during cesarean section from May 2008 to June 2011 were selected, including twelve patients with placenta previa, one patient with shallow placental implantation, two patients with placental abruption and uterine apoplexy, and three patients with uterine inertia. Modified B - Lynch suture combined with filling uterine cavity with gauze was used for hemostasis by compression. Results: Bleeding was stopped in the eighteen patients, gauze was pulled out after 24 hours, and bleeding didnt appeared. After operation, two patients were found with temperature more than 38. 5t, and One patient was found with temperature more than 39%. All the patients left the hospital at 5 -7 days after operation, involution of uterus was good at 42 days after delivery. Conclusion: The clinical efficacy of modified B - Lynch suture combined with filling uterine cavity with gauze is satisfactory in controlling intractable bleeding during cesarean section, the method is easy to operate and safe, which reserves the reproductive function of the patients and it is worthy to be popularized in clinic.%目的:探讨改良B-Lynch缝合联合宫腔填纱在剖宫产术中难治性出血的治疗效果.方法:选择2008年5月~2011年6月剖宫产术中出现难治性出血18例患者,其中前置胎盘12例,胎盘浅植入1例,胎盘早剥子宫卒中2例,宫缩乏力3例.采用改良B-Lynch缝合联合宫腔填纱压迫止血.结果:18例患者均止血成功,24h取纱未出现再出血.术后体温超过38.5C2例,超过39℃1例.全部病例术后5~7天出院,产后42天子宫复旧良好.结论:改良B-Lynch缝合联合宫腔填纱控制剖宫产术中难治性出血效果满意,操作简单、安全,保留了患者生育机能,值得临床推广应用.

  8. Medical image of the week: Lynch syndrome

    Directory of Open Access Journals (Sweden)

    Athale A

    2016-11-01

    Full Text Available No abstract available. Article truncated at 150 words. A 43-year-old woman with a history of anemia, thrombocytopenia, and recent treatment for pyelonephritis was transferred to our hospital for increasing shortness of breath. Four months prior to admission, she developed unprovoked bilateral deep vein thrombosis (DVT and pulmonary emboli (PE and was started on rivaroxaban at that time. At presentation, she was complaining of worsening shortness of breath, heavy menstrual bleeding and pain in her calves. CT angiography of chest showed multiple pulmonary emboli to the lower lobes and left upper lobe (Figure 1 and lower extremity venous Doppler showed extensive, acute deep vein thrombosis involving the femoral, popliteal and calf veins bilaterally. Rivaroxaban was held due to anemia and thrombocytopenia and there was concern for respiratory failure since she developed new DVT and PE. She was transfused with 1 unit of packed red blood cells and started on a heparin drip. She continued to have significant menorrhagia, the ...

  9. 100 years lynch syndrome

    DEFF Research Database (Denmark)

    Bleiker, Eveline M A; Esplen, Mary Jane; Meiser, Bettina

    2013-01-01

    by an overview of important psychosocial issues identified in the past 20 years. The identification of mismatch repair genes in 1993-1994 made possible genetic counseling and testing for patients who had cancer and for potentially high-risk relatives without cancer. At that time, concerns were raised about......, reproductive technology utilization, and professional psychosocial support needs of members of families with LS. Finally, challenges for the future are discussed, including population screening and genomic testing....

  10. Twenty hanging Dolls and a Lynching:

    DEFF Research Database (Denmark)

    Risør, Helene

    2010-01-01

    paradoxical entanglement with the enactments of citizenship and state-citizen relations, the article argues that people's attempts to remain safe constitute a permanent process of making visible and defacing (following Michael Taussig's notion of defacement) dangerousness and criminal subjects vis...

  11. Massachusetts Supplemental - Lynch vs. Rank File

    Data.gov (United States)

    Social Security Administration — Result of a Court Case. To identify, to the States (except Massachusetts and others who have opted out), Title 2 beneficiaries who had lost SSI benefits during the...

  12. Emotional Autonomy Redux: Revisiting Ryan and Lynch.

    Science.gov (United States)

    Lamborn, Susie D.; Steinberg, Laurence

    1993-01-01

    Compared adjustment scores among adolescents who differ in both emotional autonomy and perceptions of parental support. Found that, although adolescents who scored high in both emotional autonomy and relationship support reported more internal distress and behavior problems than less autonomous adolescents, they had higher levels of psychological…

  13. Observation of curative effect of modified B-Lynch suture combined with intrauterine balloon tamponade in the treatment of postpartum hemorrhage caused by uterine inertia%改良B-lynch缝合联合水囊填塞法治疗宫缩乏力性产后出血的疗效观察

    Institute of Scientific and Technical Information of China (English)

    刘丽霞

    2016-01-01

    Objective To evaluate the efficacy of modified B-Lynch suture combined with intrauterine balloon tamponade in the treatment of postpartum hemorrhage caused by uterine inertia.Methods 38 cases of postpartum hemorrhage caused by uterine inertia in our department from January 2011 to December 2015 underwent modified B-Lynch suture combined with intrauterine balloon tamponade (observation group),23 cases of postpartum hemorrhage caused by uterine inertia in our department from January 2006 to December 2010 underwent intrauterine balloon tamponade (control group).Clinical efficacy,hemostatic time,the amount of bleeding,and complications were compared between two groups.Results The effective rate of observation group was 94.7% (36/38),significantly higher than that of control group [73.9% (17/23)],with statistically significant difference between two groups (P<0.05).The operation time of observation group was longer than that of control group,the hemostasis time of observation group was shorter than that of control group,with statistically significant differences between two groups (P<0.05).There were no complications such as water sac shedding or cervical necrosis in both groups.Conclusion Modified B-Lynch suture combined with intrauterine balloon tamponade is effective in the treatment of postpartum hemorrhage caused by uterine inertia.%目的 探讨改良B-lynch缝合联合水囊填塞法治疗宫缩乏力性产后出血的临床治疗效果.方法 2011年1月至2015年12月采用改良B-lynch缝合联合水囊填塞法治疗的38例宫缩乏力性产后出血患者作为观察组,2006年1月至2010年12月单纯采用水囊填塞法治疗的23例宫缩乏力性产后出血患者为对照组.比较两组患者的临床疗效、止血时间、出血量及相关并发症.结果 观察组有效率为94.7%(36/38),显著高于对照组的73.9%(17/23),两组临床疗效比较差异有统计学意义(P<0.05).观察组手术时间长于对照组、止血时间

  14. The Yarn Filling in Uterine Cavity and Improved B-Lynch Suture in the Treatment of Intractable Hemorrhage in Cesarean Section%宫腔填纱条与改良B-Lynch缝合治疗剖宫产术中难治性出血的体会

    Institute of Scientific and Technical Information of China (English)

    梁日新

    2015-01-01

    目的:探讨宫腔填纱条与改良B-Lynch缝合治疗剖宫产术中难治性出血的临床应用及疗效,并观察和分析其安全性。方法:选择笔者所在医院2007年1月-2013年12月剖宫产难治性出血患者共40例,分为对照组和研究组,每组20例。对照组应用宫腔填纱条,研究组应用改良B-Lynch缝合法,观察治疗效果、术中出血量、术后阴道出血量及并发症,并观察6个月后月经来潮等指标。结果:两组均能有效控制产后出血,有效率达100%。研究组术中出血量、手术时间和阴道出血量、术后感染率、输血和住院时间分别为(894.63±67.21)ml、(76.13±8.52)min、(25.17±4.63)ml、0、(661.57±30.32)ml和(7.12±0.96)d,均低于对照组,两组比较差异均有统计学意义(P0.05)。结论:改良B-Lynch缝合治疗剖宫产术中难治性出血的止血效果明显优于宫腔填纱条法,止血迅速可靠,能够降低患者并发症。%Objective:To explore the clinical application and effect of the yarn filling in uterine cavity and improved B-Lynch suture for the treatment of intractable hemorrhage in cesarean section,and observe and analyze its security.Method:40 cesarean section patients with intractable hemorrhage were selected in the hospital from January 2007 to December 2013,they were randomly divided into the control group and the research group,20 cases each group. The control group used the uterine cavity filling yarn,the research group used improved B-Lynch suture.To observe treatment effect,intraoperative blood loss, postoperative vaginal blood loss and complication,and observed 6 months after menstrual cramps and other indicators.Result:Both groups can effectively control postpartum,100%efficient,there was no statistically significant difference(P>0.05).The intraoperative blood loss,operating time and blood loss,postoperative vaginal infection,blood transfusion and length of hospital stay time of the research group

  15. Observation on Efficacy of Improved B-lynch Sutura Combined with Carboprost Tromethamine in Treatment of Postpartum Hemorrhage Caused by Uterine Inertia%改良B-Lynch缝合术联合卡前列素氨丁三醇治疗宫缩乏力性产后出血的疗效观察

    Institute of Scientific and Technical Information of China (English)

    肖先绪; 郑红梅

    2016-01-01

    OBJECTIVE:To investigate the efficacy and safety of improved b-lynch sutura combined with carboprost tromethamine in treatment of postpartum hemorrhage caused by uterine inertia .METHODS:102 patients with postpartum hemorrhage caused by uterine inertia admitted from Apr .2011 to Apr.2015 were selected to be divided into two groups .Both groups were treated with traditional treatment , and the control group ( 51 cases ) additionally received carboprost tromethamine , the observation group ( 61 cases ) were additionally given improved b-lynch sutura combined with carboprost tromethamine .The efficacy and occurrence of adverse drug reactions were compared between two groups .RESULTS: The mean operative time of observation group was ( 165.3 ±33.2 ) min, significantly shorter than that of control group [ ( 226.5 ±25.4 ) min ] , with statistically significant difference ( P0.05 ) .After treatment , the bleeding rate of postoperative 2 h, hysterectomy rate and hemostatic efficiency of observation group were significantly higher than that of control group , with statistically significant difference ( P<0.05 ) .The incidence of stomachache , ileus and puerperalism of observation group were significantly lower than that of control group , with statistically significant difference (P<0.05).There was no complications of intestinal adhesion in both groups .CONCLUSIONS:The efficacy of improved b-lynch sutura combined with carboprost tromethamine in treatment of postpartum hemorrhage caused by uterine inertia is remarkable , with high safety , which is worthy of application and promotion .%目的:改良B-Lynch缝合术联合卡前列素氨丁三醇治疗宫缩乏力性产后出血的控血效果及安全性。方法:纳入2011年5月—2015年5月收治的102例剖宫产术中发生宫缩乏力的患者,以随机数字表法分为2组。2组患者均给予传统治疗方案,对照组患者(51例)加用卡前列素氨丁三醇,观察组患者(61例)则加用

  16. A reply to the replies – Counterplea by Jake Lynch

    Directory of Open Access Journals (Sweden)

    Jake Lynch

    2007-10-01

    Full Text Available In this paper the author responds to the counterpleas by David Loyn (“Good journalism or peace journalism?” and Thomas Hanitzsch (“It should be fair to criticize even noble ideas” published in the same issue of conflict & communication online (http://www.cco.regener-online.de/2007_2/inhalt6_2.htm.

  17. Revised guidelines for the clinical management of Lynch syndrome (HNPCC)

    DEFF Research Database (Denmark)

    Vasen, Hans F A; Blanco, Ignacio; Aktan-Collan, Katja

    2013-01-01

    important clinical questions. Then a systematic literature search was performed using the Pubmed database and manual searches of relevant articles. During the workshops the outcome of the literature search was discussed in detail. The guidelines described in this paper may be helpful for the appropriate...

  18. Pathological assessment of mismatch repair gene variants in Lynch syndrome

    DEFF Research Database (Denmark)

    Rasmussen, Lene Juel; Heinen, Christopher D; Royer-Pokora, Brigitte;

    2012-01-01

    . Also, identifying family members that do not carry the variant is important so they can be released from the intensive surveillance. Determining which genetic variants are pathogenic and which are neutral is a major challenge in clinical genetics. The profound mechanistic knowledge on the genetics...

  19. Indsigter og udfordringer i danske Lynch-syndrom-familier

    DEFF Research Database (Denmark)

    Therkildsen, Christina; Timshel, Susanne; Nilbert, Mef

    2008-01-01

    The Danish Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Register is a national resource that registers families with hereditary colorectal cancer. HNPCC is the most common type of hereditary colorectal cancer and carries an increased risk of other tumor types. Genetic diagnostics has identif...

  20. 大卫·林奇访谈录%Interview with David Lynch

    Institute of Scientific and Technical Information of China (English)

    普莱瑞·米勒; 蔡卫

    2003-01-01

    @@ 另类的电影人大卫·林奇通过他的新片故伎重演,在对观众实施催眠的同时又在对观众进行迷惑.这部故事发生在洛杉矶的影片探讨了这座城市精神分裂式的本性,它是纯真与腐败、爱恋与孤独、美好与堕落之间令人不安的融合.也许这些对立映射了林奇本人的生活,就是他既与洛杉矶好莱坞电影业努力保持合作关系、又极力保持自己的艺术个性.

  1. David Lynch's Sayings%大卫·林奇语录

    Institute of Scientific and Technical Information of China (English)

    游飞

    2003-01-01

    @@ 最好不要太多地追究事件的含义、或者琢磨怎样去加以解释,不然你就会因恐惧而不敢让事件发生.心理学摧毁了神秘感和一些魔幻性特质.它能够被贬低为某种神经官能症和其它东西,但它目前的名称和界定却使之丧失了神秘性,以及体验巨大和无限的可能.

  2. The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome

    DEFF Research Database (Denmark)

    Watson, Patrice; Vasen, Hans F A; Mecklin, Jukka-Pekka;

    2008-01-01

    strategies for these less common cancers require accurate, age-specific risk estimation. We pooled data from 4 LS research centers in a retrospective cohort study, to produce absolute incidence estimates for these cancer types, and to evaluate several potential risk modifiers. After elimination of 135...... after the median year of birth (p evaluate...

  3. Improvement of endometrial biopsy over transvaginal ultrasound alone for endometrial surveillance in women with Lynch syndrome.

    NARCIS (Netherlands)

    Gerritzen, L.H.; Hoogerbrugge-van der Linden, N.; Oei, A.L.M.; Nagengast, F.M.; Ham, M.A.P.C. van; Massuger, L.F.A.G.; Hullu, J.A. de

    2009-01-01

    In women with hereditary non polyposis colorectal carcinoma (HNPCC) an annual gynaecological surveillance has been recommended because of an increased lifetime risk of developing endometrial and ovarian carcinoma. The aim of this study was to assess the efficacy of gynaecological surveillance with r

  4. DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch Syndrome

    OpenAIRE

    Poulogiannis, George; Frayling, Ian; Arends, Mark

    2009-01-01

    Abstract DNA mismatch repair (MMR) deficiency is one of the best understood forms of genetic instability in colorectal cancer (CRC), and is characterised by the loss of function of the MMR pathway. Failure to repair replication-associated errors due to a defective MMR system allows persistence of mismatch mutations all over the genome, but especially in regions of repetitive DNA known as microsatellites, giving rise to the phenomenon of microsatellite instability (MSI). A high freq...

  5. 75 FR 78745 - Ronald Lynch, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-12-16

    ... ] following day he received a telephone call from ``Jasmine at Modern Lifestyles,'' who asked ``what type of..., acupuncture and eating ``certain anti-inflammatory foods.'' Id. at 210, 214-15. He also maintained that he... prescribing or dispensing of a dangerous drug ``on the Internet for delivery to any person in this state...

  6. The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome

    DEFF Research Database (Denmark)

    Watson, Patrice; Vasen, Hans F A; Mecklin, Jukka-Pekka

    2008-01-01

    persons missing crucial information, cohort included 6,041 members of 261 families with LS-associated MLH1 or MSH2 mutations. All were either mutation carriers by test, probable mutation carriers (endometrial/colorectal cancer-affected), or first-degree relatives of these. Among mutation carriers...... and probable carriers, urologic tract cancer (N = 98) had an overall lifetime risk (to age 70) of 8.4% (95% CI: 6.6-10.8); risks were higher in males (p families (p ... after the median year of birth (p families (p

  7. A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndrome

    DEFF Research Database (Denmark)

    Boonstra, Philip S; Gruber, Stephen B; Raymond, Victoria M

    2010-01-01

    , and this right truncation effect is more pronounced in children than in parents. In this study, we first review different statistical methods for testing genetic anticipation in affected parent-child pairs that address the issue of bias due to right truncation. Using affected parent-child pair data, we compare......Anticipation, manifested through decreasing age of onset or increased severity in successive generations, has been noted in several genetic diseases. Statistical methods for genetic anticipation range from a simple use of the paired t-test for age of onset restricted to affected parent-child pairs...... to a recently proposed random effects model which includes extended pedigree data and unaffected family members [Larsen et al., 2009]. A naive use of the paired t-test is biased for the simple reason that age of onset has to be less than the age at ascertainment (interview) for both affected parent and child...

  8. Frequent mismatch-repair defects link prostate cancer to Lynch syndrome

    DEFF Research Database (Denmark)

    Dominguez-Valentin, Mev; Joost, Patrick; Therkildsen, Christina;

    2016-01-01

    were high-grade tumors with Gleason scores 8-10. Prostate cancer was associated with mutations in MSH2, MLH1 and MSH6 with loss of the respective mismatch repair protein in 69 % of the tumors, though a MSI-high phenotype was restricted to 13 % of the tumors. The cumulative risk of prostate cancer...

  9. Bayesian Modeling for Genetic Anticipation in Presence of Mutational Heterogeneity: A Case Study in Lynch Syndrome

    DEFF Research Database (Denmark)

    Boonstra, Philip S; Mukherjee, Bhramar; Taylor, Jeremy M G

    2011-01-01

    Summary Genetic anticipation, described by earlier age of onset (AOO) and more aggressive symptoms in successive generations, is a phenomenon noted in certain hereditary diseases. Its extent may vary between families and/or between mutation subtypes known to be associated with the disease phenoty...

  10. A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndrome

    DEFF Research Database (Denmark)

    Boonstra, Philip S; Gruber, Stephen B; Raymond, Victoria M

    2010-01-01

    Anticipation, manifested through decreasing age of onset or increased severity in successive generations, has been noted in several genetic diseases. Statistical methods for genetic anticipation range from a simple use of the paired t-test for age of onset restricted to affected parent-child pairs......, and this right truncation effect is more pronounced in children than in parents. In this study, we first review different statistical methods for testing genetic anticipation in affected parent-child pairs that address the issue of bias due to right truncation. Using affected parent-child pair data, we compare...... to a recently proposed random effects model which includes extended pedigree data and unaffected family members [Larsen et al., 2009]. A naive use of the paired t-test is biased for the simple reason that age of onset has to be less than the age at ascertainment (interview) for both affected parent and child...

  11. Screening for urinary tract cancer with urine cytology in Lynch syndrome and familial colorectal cancer

    DEFF Research Database (Denmark)

    Myrhøj, T; Andersen, M-B; Bernstein, I

    2008-01-01

    AIM: The aim of this study was to evaluate if Urine Cytology (UC) is an appropriate screening procedure for detecting urinary tract neoplasia at an early stage in persons at risk in Hereditary Non-Polyposis Colorectal Cancer families. METHOD: In the National Danish HNPCC-register persons at risk...

  12. The Failure of Lehman Brothers and Merril Lynch: A Lesson for the ...

    African Journals Online (AJOL)

    DR Nneka

    procedures were not instituted rather they depend on subprime mortgage ... Andabai (2011) asserted that, bank failures in emerging financial system had dramatic effects on their economics, and even when crisis are prevented, the cost of.

  13. Educational Lynching: Critical Race Theory and the Suspension of Black Boys

    Science.gov (United States)

    Payne, Macheo

    2010-01-01

    Looking at the disproportionate suspension of African American, Black male students through the lens of critical race theory, this presents arguments from a CRT how the disproportionate suspension of Black male students is rooted in white supremacy and racist policy in the United States. Local recommendations are offered for Oakland Unified School…

  14. Pestilence, riots, lynchings and desecration of corpses. The sleep of reason produces monsters.

    Science.gov (United States)

    Sabbatani, Sergio; Fiorino, Sirio

    2016-06-01

    Vampirism has been a component of Central European and Balkan folklore since the Middle Ages and was often believed to be responsible for the transmission of serious infectious diseases such as plague and tuberculosis/consumption. Vampirism was believed to be spread within the same family or village and if the rite of the so-called second burial after death was not performed. The practice of "second burial" entailed exhumation of the body and the removal of the shroud from the mouth of the corpse, and a search for evidence if the corpse had chewed the cloth. If the shroud was chewed, a handful of earth or a brick was put into the body's mouth so that the vampire could no longer harm others. In some cases, the corpse was decapitated and an awl, made of ash, was thrust into its chest. Furthermore, the limbs were nailed down to prevent its movements. Remarkably, these beliefs were not restricted to the popular classes, but were also debated by theologians, political scientists at the height of the eighteenth century (Enlightenment). In the Habsburg Empire, this question attained such important political, social as well as health connotations as to force the Empress Maria Theresa to entrust an ad hoc study to her personal physician Gerard van Swieten with a view to determining what was true about the apparitions of vampires that occurred throughout central Europe and in the Balkans. The result of this investigation led to a ban on the "second burial" rites. Despite this prohibition, the practice of necrophilia on the bodies of suspected people continued, and both a cultured and popular literature on vampirism continued to flourish well into the nineteenth century.

  15. Diagnosis of Lynch Syndrome: Genetic Testing Identifies a Potentially Deadly Hereditary Disease

    Science.gov (United States)

    ... the sequencing can identify variants in a person’s genes—places where their genetic sequence differs from an expected sequence,” says Katie Lewis, a research coordinator at NIH’s National Human Genome ...

  16. Functional characterization of MLH1 missense variants identified in Lynch Syndrome patients

    DEFF Research Database (Denmark)

    Andersen, Sofie Dabros; Liberti, Sascha Emilie; Lützen, Anne;

    2012-01-01

    localization and protein-protein interaction with the dimer partner PMS2 and the MMR-associated exonuclease 1. We show that a significant proportion of examined variant proteins have functional defects in either subcellular localization or protein-protein interactions, which is suspected to lead to the cancer...

  17. Hereditary colorectal cancer syndromes: Epidemiological studies on Peutz-Jeghers syndrome & Lynch syndrome

    NARCIS (Netherlands)

    M.G.F. van Lier (Margot)

    2011-01-01

    textabstractColorectal cancer (CRC) is the second most common malignancy among women after breast cancer, and the third most common malignancy among men after lung and prostate cancer in the European Union. In the Netherlands, approximately 10000 cases are diagnosed each year. CRC is moreover associ

  18. Poliitiliselt korrektselt on raske sündimust suurendada / Villu Zirnask

    Index Scriptorium Estoniae

    Zirnask, Villu, 1966-

    2008-01-01

    Autor käsitleb majandusteadlaste Vincenzo Galasso, Roberta Gatti ja Paola Profeta ning Matthias Doepke, Moshe Hazani ja Yishay D. Maozi sündimusteemalist uuringut ning järeldab, et praegustes tingimustes on võimatu samasugust beebibuumi esile kutsuda, kui oli 1950. aastatel. Diagramm: Sündimuse määra trend Eestis, Soomes ja Saksamaal 1950-2005

  19. Poliitiliselt korrektselt on raske sündimust suurendada / Villu Zirnask

    Index Scriptorium Estoniae

    Zirnask, Villu, 1966-

    2008-01-01

    Autor käsitleb majandusteadlaste Vincenzo Galasso, Roberta Gatti ja Paola Profeta ning Matthias Doepke, Moshe Hazani ja Yishay D. Maozi sündimusteemalist uuringut ning järeldab, et praegustes tingimustes on võimatu samasugust beebibuumi esile kutsuda, kui oli 1950. aastatel. Diagramm: Sündimuse määra trend Eestis, Soomes ja Saksamaal 1950-2005

  20. Para una des-comprensión filosófica del cine: el caso Inland Empire de David Lynch

    Directory of Open Access Journals (Sweden)

    Julio Cabrera

    2009-05-01

    Full Text Available El trabajo cuestiona la capacidad hermenéutica de la filosofía en su tarea de analizar películas, sosteniendo quetal capacidad dejó de ser apropiada para hacer surgir el sentido y la verdad de obras cinematográficas. Se argumentaque una capacidad interactiva y “performativa” sería más adecuada. Obras cinematográficas como las de David Lynchayudan a entender este paso metodológico y temático desde la noción interpretativa de la verdad hacia la noción interactivade la misma, al construir filmes que se configuran como “imposibles hermenéuticos”. El artículo contiene unaauto-crítica a la propia actitud hermenéutica aún asumida en mi libro Cine: 100 años de filosofía, de 1999.

  1. 论大卫·林奇电影的不确定性%The Uncertainty of David Lynch's Films

    Institute of Scientific and Technical Information of China (English)

    陈慧

    2005-01-01

    从文本的角度研究林奇的电影,我们便可看出其电影的特点是不确定性,这是后现代主义的典型特征之一.探讨林奇电影的不确定性有助于更好地了解其电影作品及艺术.

  2. Chemical, Biological, and Physical Measurements from the Subtropical Western North Atlantic Ocean. Summer 1982, USNS LYNCH, Cruise 710-82.

    Science.gov (United States)

    1985-01-01

    purified luciferin -luciferace system (DuPont Inc., Wilmington, Delaware). The resulting light emission was measured in a sensitive photometer (SAI Inc...35 57.4 N 074 55.4 W Transm 23 1 Transmiss 0 25 June 82 0945 36 56.6 N 075 59.1 W Transm 10 tivity and temperature fine structure seen in the...chlorophyll "a" (chl "a") PHAEOPHYTIN mg/L total phaeopigment (i.e., chlorophyll degradation products) PHOSPHATE ug- atoms /L = AM dissolved

  3. Family perspectives in lynch syndrome becoming a family at risk, patterns of communication and influence on relations

    DEFF Research Database (Denmark)

    Bartuma, Katarina; Nilbert, Mef; Carlsson, Christina

    2012-01-01

    A growing number of individuals are diagnosed with hereditary cancer. Though increased levels of anxiety and depression have been demonstrated around the time of genetic counselling, most individuals handle life at increased risk well. Data have, however, been collected on individual basis, which...... led us to focus on family perspectives of hereditary cancer....

  4. Detección de mutaciones germinales en el gen PMS2 asociado a Síndrome de Lynch

    OpenAIRE

    2014-01-01

    Según la Organización Mundial de la Salud (OMS) el cáncer se define como un término genérico que designa un amplio grupo de enfermedades que pueden afectar a cualquier parte del organismo; también se habla de «tumores malignos» o «neoplasias malignas». Una característica del cáncer es la multiplicación rápida de células anormales que se extienden más allá de sus límites habituales y pueden invadir partes adyacentes del cuerpo o propagarse a otros órganos, proceso conocido como ...

  5. 77 FR 26008 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-05-02

    ... License. CLN Worldwide, LLC (NVO & OFF), 1825-C Cross Beam Drive, Charlotte, NC 28217, Officer: David E..., Officers: Robin Lynch, Managing Member (Qualifying Individual), Gina Lynch, Member, Application...

  6. David Lynch's Movie World%在梦里他对你说 --大卫·林奇的电影世界

    Institute of Scientific and Technical Information of China (English)

    蔡卫

    2003-01-01

    @@ 空荡的房间低垂着殷红的帷幕,黑白相间的地板上,闪烁着鬼火般的灯光,一个男人僵硬地坐在一张椅子里,空气中弥漫着隐隐人的嗡鸣,渐渐地,嗡鸣声吞没了一只萨克斯管孤独的曲调……一个穿着红西装的侏儒小男人正面对帷幕全身颤抖着难以支撑,他紧紧抓住红色帷幕,仿佛那是他生命依附的力量.渐渐地,一股潜在的生命力涌入侏儒的躯体,他从抽搐中恢复过来,转过身面对着座椅上的男人,然后伴随着强劲的爵士乐曲舞蹈起来.侏儒的嘴唇嚅动着,怪异、模糊的声音在躁动窒息的空间回荡,仿佛在说"来,一起去跳舞……"

  7. A Reflection on David Lynch's Film Style%关于大卫·林奇电影风格的思考

    Institute of Scientific and Technical Information of China (English)

    周艳

    2013-01-01

    通过对林奇电影和好莱坞电影工业的研究表明,大卫·林奇的电影对于好莱坞工业的固有程式实现了勇敢的突破,但时至今日,设若林奇式的电影梦境能够有机植入侦探片、黑帮片抑或现实主义等其他类型片,或者沉潜入更为深广的集体潜意识梦境当中,将会再次因为与当今观众对话的可能而发挥它“惊人的效果”,成为电影中经久不衰的影像表达方式.

  8. Prevalence of MLH1 constitutional epimutations as a cause of Lynch syndrome in unselected versus selected consecutive series of patients with colorectal cancer.

    Science.gov (United States)

    Castillejo, Adela; Hernández-Illán, Eva; Rodriguez-Soler, María; Pérez-Carbonell, Lucía; Egoavil, Cecilia; Barberá, Victor M; Castillejo, María-Isabel; Guarinos, Carla; Martínez-de-Dueñas, Eduardo; Juan, María-Jose; Sánchez-Heras, Ana-Beatriz; García-Casado, Zaida; Ruiz-Ponte, Clara; Brea-Fernández, Alejandro; Juárez, Miriam; Bujanda, Luis; Clofent, Juan; Llor, Xavier; Andreu, Montserrat; Castells, Antoni; Carracedo, Angel; Alenda, Cristina; Payá, Artemio; Jover, Rodrigo; Soto, José-Luis

    2015-07-01

    The prevalence of MLH1 constitutional epimutations in the general population is unknown. We sought to analyse the prevalence of MLH1 constitutional epimutations in unselected and selected series of patients with colorectal cancer (CRC). Patients with diagnoses of CRC (n=2123) were included in the unselected group. For comparison, a group of 847 selected patients with CRC who fulfilled the revised Bethesda guidelines (rBG) were also included. Somatic and constitutional MLH1 methylation was assayed via methylation-specific multiplex ligation-dependent probe amplification of cases lacking MLH1 expression. Germline alterations in mismatch-repair (MMR) genes were assessed via Sanger sequencing and methylation-specific multiplex ligation-dependent probe amplification. Loss of MLH1 expression occurred in 5.5% of the unselected series and 12.5% of the selected series (pprevalence of MLH1 constitutional epimutations in unselected cases of CRC. Therefore, MLH1 constitutional epimutation analysis should be conducted only for patients who fulfil the rBG and who lack MLH1 expression with methylated MLH1. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  9. 浏览器端开发最佳实践:浏览器端的狙击——蔡学镛对话Kevin Lynch

    Institute of Scientific and Technical Information of China (English)

    朱海燕; 常政; 蔡学镛

    2006-01-01

    2005年4月,《程序员》杂志发表专题文章“高效开发团队最佳实践”,时至今日仍然常有读者对当期文章赞不绝口。于是,经过一年多之后,我们又再次回到当时的出发点。

  10. On the Research Methods of the Urban Image of Kevin Lynch%凯文·林奇城市意象研究方法辨析

    Institute of Scientific and Technical Information of China (English)

    杨健; 戴志中

    2007-01-01

    在建筑学研究方法的众多主张中,最引人注目的观点是认为存在着经验主义与理性主义两种根本对立的研究方法.但是,在凯文·林奇的城市意象研究中,我们并没有看到这种决然的二元对立.通过对林奇城市意象研究方法(包括对林奇采用的心理学、现象学研究方法,以及所采用的心理学和人类学文献)所作的考察,试图证明建筑学研究可以是实证与思辨、定量与定性、科学与神话的有机统一.建筑学不排斥诗意,建筑学研究同样不排斥诗意盎然的研究方法.

  11. 凯文·林奇《城市意象》之批判%Critical Reading on Kevin Lynch's The Image of the City

    Institute of Scientific and Technical Information of China (English)

    汪原

    2003-01-01

    凯文@林奇的城市五要素早已广泛运用于城市设计中,以建构更易识别的环境.但其局限性也是显而易见的,即将人对城市环境的理解仅仅看做是对物质形态的知觉认识.通过对凯文@林奇的再解读,不仅指出了城市意象研究的局限性,而且从文化和意识形态方面对意象研究进行了探讨.

  12. 凯文·林奇城市设计教育思想解读%Review of the Urban Design Educational Thought of Kevin Lynch

    Institute of Scientific and Technical Information of China (English)

    董禹; 董慰

    2006-01-01

    凯文·林奇的城市设计思想在世界上影响广泛,本文基于林奇对城市设计的独到见解,从教学内容、教学方法、课程设置、教学机构几个方面介绍并分析了林奇关于城市设计教育的观点,以期能对我国城市设计教育的完善起到借鉴作用.

  13. The introduction of a choice to learn pre-symptomatic DNA test results for BRCA or Lynch syndrome either face-to-face or by letter

    NARCIS (Netherlands)

    Voorwinden, J. S.; Jaspers, J. P. C.; ter Beest, J. G.; Kievit, Y.; Sijmons, R. H.; Oosterwijk, J. C.

    2012-01-01

    In predictive DNA testing for hereditary cancer, test results should traditionally be disclosed face-to-face. Increasingly, however, counselees ask to receive their test result at home by letter. To compare the quality of genetic counselling in the traditional way to a procedure in which counselees

  14. Triple synchronous primary malignancies of the colon, endometrium and kidney in a patient with Lynch syndrome treated via minimally invasive techniques

    Directory of Open Access Journals (Sweden)

    Luis E. Mendez

    2016-08-01

    It is important to consider hereditary cancer syndromes in women with a strong family history presenting with synchronous multiple primary malignancies. A multidisciplinary surgical approach is key to best practices and optimal patient outcomes.

  15. Immunohistochemical staining for p16 and BRAFV600E is useful to distinguish between sporadic and hereditary (Lynch syndrome-related) microsatellite instable colorectal carcinomas.

    Science.gov (United States)

    Boissière-Michot, Florence; Frugier, Hélène; Ho-Pun-Cheung, Alexandre; Lopez-Crapez, Evelyne; Duffour, Jacqueline; Bibeau, Frédéric

    2016-08-01

    DNA mismatch repair (MMR) protein analysis by immunohistochemistry (IHC) can identify colorectal cancer (CRC) with microsatellite instability (MSI). As MLH1-deficient CRC can be hereditary or sporadic, markers to distinguish between them are needed. MLH1 promoter methylation assay is the reference method; however, sometimes, it is challenging on formalin-fixed paraffin-embedded tissue samples. We assessed by IHC the expression of BRAFV600E, p16, MGMT, and CDX2 in 55 MLH1-deficient MSI CRC samples (of which 8 had a germline MLH1 mutation) to determine whether this panel differentiates between sporadic and hereditary CRCs. We also analyzed MLH1 promoter methylation by methylation-specific PCR and pyrosequencing and BRAF status by genotyping. None of the hereditary CRCs showed MLH1 methylation, BRAF mutation, BRAFV600E-positive immunostaining, or loss of p16 expression. We detected MLH1 promoter methylation in 67 % and a BRAF mutation in 42 % of CRC, all showing MLH1 promoter methylation. BRAFV600E IHC and BRAF genotyping gave concordant results in all but two samples. Loss of expression of p16 was found in 30 % of CRC with methylation of the MLH1 promoter, but its expression was retained in all non-methylated and part of MLH1-methylated tumors (100 % specificity, 30 % sensitivity). CDX2 and MGMT expression was not associated with MLH1 status. Thus, BRAFV600E and p16 IHC may help in differentiating sporadic from hereditary MLH1-deficient CRC with MSI. Specifically, p16 IHC might be used as a surrogate marker for MLH1 promoter methylation, because all p16-negative CRCs displayed MLH1 methylation, whereas hereditary CRCs were all p16-positive.

  16. Genetics Home Reference: Peutz-Jeghers syndrome

    Science.gov (United States)

    ... Genetic and Rare Diseases Information Center Frequency The prevalence of this condition is uncertain; estimates range from ... A, Lynch HT, Lynch JF, Howe JR. Hereditary colorectal cancer-part II. Curr Probl Surg. 2005 May;42( ...

  17. THE ARTISTS

    National Research Council Canada - National Science Library

    2013-01-01

    ... FOR QUIETLY BREAKING THE KINGDOM'S GENDER BARRIERS FILM DIRECTOR | BAHRAIN * As a film website put it this fall, a study of Saudi cinema "would essentially begin and end with Haifaa Al Mansour." As the director of the 2005 documentary Women Without Shadows and the recent, critically acclaimed Wadjda--the first feature film shot entirely in ...

  18. In Situ XAFS Study of Oxides Formed on Nickel Thin Film Electrodes in KOH Solution.

    Science.gov (United States)

    1994-12-05

    Thin Film Electrodes in KOH Solution by A. N. Mansour and C. A. Melendres Prepared for Publication in the Electrochemical Society Extended Abstracts...document has been approved for public release and sale; its distribution is unlimited. 19941209 042 The 187th Meeting of the Electrochemical Society Reno

  19. Browse Title Index - African Journals Online

    African Journals Online (AJOL)

    Items 9101 - 9150 of 11090 ... Asad Maroufi, Mansour Karimi, Khosro Mehdikhanlou, Erik Van Bockstaele, Marc De Loose. Vol 8, No 22 .... E Barranco-Florido, LA García-Hernández, S Rodríguez-Navarro, A Flores-Macías, MA Ramos-López.

  20. Key-Alternating Ciphers in a Provable Setting: Encryption Using a Small Number of Public Permutations (Extended Abstract)

    DEFF Research Database (Denmark)

    Bogdanov, Andrey; Knudsen, L.R.; Leander, Gregor

    2012-01-01

    This paper considers—for the first time—the concept of key-alternating ciphers in a provable security setting. Key-alternating ciphers can be seen as a generalization of a construction proposed by Even and Mansour in 1991. This construction builds a block cipher PX from an n-bit permutation P and...

  1. David Lynch Talks the Marvellous Creativity%一个美妙的头脑--电影制作者大卫·林奇谈奇妙的神秘创意

    Institute of Scientific and Technical Information of China (English)

    布莱特·西蒙; 游飞

    2003-01-01

    @@ 首先申明,这篇文章将不能命名为,它将避免依据众所周知的事实来对林奇的创作进行艺术化或个性化的阐释.毕竟,已经有太多的文章对大卫·林奇的个性怪僻、习惯和电影影像进行了过于繁琐细致的分类和盘查.因此:经常特异的装束(咔叽布的裤子、领口系扣的衬衫、休闲的佩饰)、瀑布般晃动的头发、独特的说话音色和热情而又大惊小怪的举止,一切都无需赘言.还有咖啡,事实上,在贝弗利山庄他的住宅兼工作室中与林奇见面,谈论这个当代文艺复兴人士的爱好和准则,就有点像是与一个老朋友见面一样.

  2. Curative effect of improved B-Lynch sutura on incurable postpartum haemorrhagia uterina%改良B-Lynch缝合术治疗产后难治性子宫出血疗效分析

    Institute of Scientific and Technical Information of China (English)

    胡立君

    2011-01-01

    目的:观察改良B-Lynch缝合术治疗产后难治性子宫出血的临床效果.方法:采用回顾性分析本院难治性产后子宫出血患者临床资料52例,按止血方法分为改良B-Lynch缝合组及对照组,比较两组患者止血成功率、子宫保留率、止血时间、术中出血量及术后24h阴道出血量.结果:两组患者均止血成功,止血成功率均为100%,改良B-Lynch缝合组子宫保留率高于对照组,改良B-Lynch缝合组止血时间短于对照组,术中出血量及术后24h阴道出血量少于对照组.结论:改良B-Lynch缝合治疗难治性子宫出血效果确切,具有较好的临床效果.

  3. Analysis on applied method in urban imago of Kevin Lynch%试析凯文·林奇在城市意象中采用的方法

    Institute of Scientific and Technical Information of China (English)

    王晓博; 窦维静

    2006-01-01

    凯文·林奇把城市作为研究对象,运用明晰的方法,将城市这一复杂综合体进行层层剖析,其本身散放着科学和理性的光芒,将城市意象中所采用的方法作为讨论主体,将有助于相关领域工作人员研究方法的提高.

  4. An Extensible and Scalable Framework for Formal Modeling, Analysis, and Development of Distributed Systems

    Science.gov (United States)

    2008-11-30

    the project personnel. All publications are available on request. [Pl| R. Canetti , L. Cheung, D. Kaynar, M. Liskov, N". Lynch, O. Pereira, and R...March 2008. [P2] Ran Canetti , Ling Cheung, Dilsun Kaynar, Nancy Lynch, and Oliviei Pereira. Modeling Bounded Computation in Long-Lived Systems. CONCUR...pages 153-1G2, 2001. [4] R. Canetti , L. Cheung. D. Kaynar, M. Liskov, N. Lynch, O. Pereirt, and R. Segala. Analyz- ing Security Protocol Using Thne

  5. Differential diagnosis of small bowel occlusions

    Directory of Open Access Journals (Sweden)

    Paolo Ghiringhelli

    2009-06-01

    Full Text Available Hereditary nonpolyposis colorectal cancer (HNPCC, also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, and microsatellite instability (MSI. Patients with Lynch syndrome have a markedly increased risk of colorectal cancer. We report a case of a 28-year-old male with Lynch syndrome; the case allows to describe clinical manifestations and diagnostic criteria of this syndrome, and to underline the importance of genetics in the diagnosis of this disease.

  6. Novel Structural Health Monitoring Schemes for Glass-Fiber Composites using Nanofillers

    Science.gov (United States)

    2014-03-31

    damage to CNT thin films ( Hou , Loh, and Lynch, 2007; Loh et al., 2009) and cementitious structures ( Hou and Lynch, 2009). Loyola et al. demonstrated...Keynote Speaker, the 36th Conference on Theoretical and Applied Mechanics, Chong Li, Taiwan, November 2012. • Distinguished Seminar Series Speaker, MAE... Hou , T. C., Loh, K. J., and Lynch, J. P., 2007. Spatial conductivity mapping of carbon nanotube composite thin films by electrical impedance

  7. 76 FR 11432 - Coding of Design Marks in Registrations

    Science.gov (United States)

    2011-03-02

    ... Classification''). DATES: Effective immediately. FOR FURTHER INFORMATION CONTACT: Cynthia C. Lynch, Office of the... search designations. Dated: February 24, 2011. David J. Kappos, Under Secretary of Commerce...

  8. 76 FR 60836 - Applicants

    Science.gov (United States)

    2011-09-30

    ... Transfer. Export Forwarders LLC (OFF), 3509 Vicky Circle, Kennesaw, GA 30144, Officers: David R. Ashford..., Officers: Robin Lynch, Managing Member (Qualifying Individual), Cutberto J. Parra Mendoza,...

  9. Pancreatic Cancer Early Detection Program

    Science.gov (United States)

    2014-07-30

    Pancreatic Cancer; Pancreas Cancer; Pancreatic Adenocarcinoma; Familial Pancreatic Cancer; BRCA 1/2; HNPCC; Lynch Syndrome; Hereditary Pancreatitis; FAMMM; Familial Atypical Multiple Mole Melanoma; Peutz Jeghers Syndrome

  10. Self-awareness rehabilitation after Traumatic Brain Injury: A pilot study to compare two group therapies.

    Science.gov (United States)

    Rigon, Jessica; Burro, Roberto; Guariglia, Cecilia; Maini, Manuela; Marin, Dario; Ciurli, Paola; Bivona, Umberto; Formisano, Rita

    2017-01-01

    Deficits of self-awareness (SA) are very common after severe acquired brain injury (sABI), especially in traumatic brain injury (TBI), playing an important role in the efficacy of the rehabilitation process. This pilot study provides information regarding two structured group therapies for disorders of SA. Nine patients with severe TBI were consecutively recruited and randomly assigned to one SA group therapy programme, according either to the model proposed by Ben-Yishay & Lakin (1989) (B&L Group), or by Sohlberg & Mateer (1989) (S&M Group). Neuropsychological tests and self-awareness questionnaires were administered before and after a 10 weeks group therapy. Results showed that both SA and neuropsychological functioning significantly improved in both groups. It is important to investigate and treat self-awareness, also to improve the outcome of neuropsychological disorders. The two group therapies proposed seem to be specific for impulsivity and emotional dyscontrol and for cognitive disorders.

  11. Towards understanding the known-key security of block ciphers

    DEFF Research Database (Denmark)

    Andreeva, Elena; Bogdanov, Andrey; Mennink, Bart

    2014-01-01

    ciphers based on ideal components such as random permutations and random functions as well as propose new generic known-key attacks on generalized Feistel ciphers. We introduce the notion of known-key indifferentiability to capture the security of such block ciphers under a known key. To show its...... meaningfulness, we prove that the known-key attacks on block ciphers with ideal primitives to date violate security under known-key indifferentiability. On the other hand, to demonstrate its constructiveness, we prove the balanced Feistel cipher with random functions and the multiple Even-Mansour cipher...... with random permutations known-key indifferentiable for a sufficient number of rounds. We note that known-key indifferentiability is more quickly and tightly attained by multiple Even-Mansour which puts it forward as a construction provably secure against known-key attacks....

  12. X-Ray Absorption Structural and Electrochemical Investigations of Novel Materials for Advanced Batteries and Ultracapacitors

    Science.gov (United States)

    1998-07-06

    Electrochemical Studies of Anodically Deposited Nickel Oxide Thin Films, The Electrochemical Society Extended Abstracts, Volume 98-1, abstract 28, San...Electrodeposited Metal Oxide Films and Some Applications", The Electrochemical Society Extended Abstracts, Volume 98-1, abstract 265, San Diego, CA, 3...Meeting of the Electrochemical Society , San Diego, CA, 3-8 May 1998. C. A. Melendres, M. Balasubramanian, A. N. Mansour, S. Mini, "X-Ray Absorption

  13. Human Health Exposure Assessment for Rocky Mountain Arsenal. Volume 2-A. Toxicity Assessment. Version 4.1

    Science.gov (United States)

    1990-09-01

    Prepared by Shell Oil Company Krzystyniak, K., PFlp, D., Mansour, S. and Fournier, M., ’Suppression of avidin processing and presentation by mouse...Chlordane or oxychlordane residues have been found in crops, meat, fish and poultry, dairy products, and eggs . Generally less than 1% of composited food...diet produced no eggs during the reproductive period, and "that adrin fed at 10 ppm reduced egg production in pheasants and reduced survival of the

  14. NAMRU-3 Reprint Accession List 1983. Number 13.

    Science.gov (United States)

    1984-01-01

    Albendazole in the Treatment of Ancylostoma duodenale and AscAris lumbricoides Infections. Trans. R. Soc. Trop. Med. Hyg., 77(2):160-11 1983. 1340 MANSOUR...synthesis 1345 CHEMOTHERAPY Albendazole in the treatment of Ancylostoma duodenale infection 1339 Albendazole in the treatment of Ascaris lumbricoides infection...tuberculous-meningitis 1350 PARASITOLOGY Amoebic.liver abscess 1330 Ancylostoma duodenale 1339 Ascaris lumbricoides 1339 Fasciola gigantica 1342

  15. The Results of a Laboratory Feasibility Study for the Biological Treatment of Umatilla Groundwater

    Science.gov (United States)

    2012-01-01

    Amendments. Amendment Supplier Contact Phone Address Lactose Columbia River Processing Roy Dugan 541·481-3770 79588 Rippee Road Whey Columbia River...degradation. RDX, on the other hand, was more difficult to treat. The best amendments were molasses, corn syrup, emulsified oil (EOS), lactose, and whey ...Environmental Processes and Engineering Division (EPED), Environmental Laboratory (EL). Dr. Fiona Crocker and Dr. Mansour Zakakhani provided in-house review

  16. Robust Control for Linear Systems with Structured Uncertainty

    Science.gov (United States)

    1988-11-01

    IEEE Transactions on Automatic Control , Vol. AC-29, no. 10, pp. 935-936, 1984. 4. Bose, N. K., "A...1985. 5. Anderson, B. D. 0., Jury, E. I., and Mansour, M., "On Robust Hurwitz Polynomials", IEEE Transactions on Automatic Control , Vol. AC-32, pp. 809...B., Berger, C. S., and Dabke, K. P., "On Stability of Polynomials with Perturbed Coefficients", IEEE Transactions on Automatic Control , Vol. AC-30,

  17. The Appearance of the Sun and Moon Seen Through Clouds

    Science.gov (United States)

    1993-12-01

    relevant conferences, I received valuable insight on my research from David Lynch , William Livingston, and others whose names I do not recall. I must...angular width. A remark by David Lynch at the 1993 Optical Society of America Topical Meeting on Light and Color in the Open Air that he had never seen a

  18. 76 FR 4554 - Notice of Establishment of the Wholesale Pork Reporting Negotiated Rulemaking Committee; Notice...

    Science.gov (United States)

    2011-01-26

    ... Avenue, St. Louis, Missouri 63105; Phone (314) 863-0400. FOR FURTHER INFORMATION CONTACT: Michael Lynch... (202) 720-6231; Fax (202) 690-3732; or e-mail at Michael.Lynch@ams.usda.gov . SUPPLEMENTARY INFORMATION... Negotiated Rulemaking Committee is in the public interest. Dated: January 21, 2011. David R....

  19. 76 FR 23513 - Wholesale Pork Reporting Negotiated Rulemaking Committee

    Science.gov (United States)

    2011-04-27

    ... (703) 684-7200. FOR FURTHER INFORMATION CONTACT: Michael Lynch, Chief; USDA, AMS, LS, LGMN Branch; 1400... at Michael.Lynch@ams.usda.gov . SUPPLEMENTARY INFORMATION: I. Background On September 28, 2010, the... Federal Register. Dated: April 22, 2011. David R. Shipman, Associate Administrator, Agricultural...

  20. 76 FR 55841 - Extension of Comment Period for Notice of Proposed Rulemaking on Changes in Requirements for...

    Science.gov (United States)

    2011-09-09

    ...-1451, attention Cynthia C. Lynch; by hand-delivery to the Trademark Assistance Center, Concourse Level, James Madison Building-East Wing, 600 Dulany Street, Alexandria, Virginia, attention Cynthia C. Lynch... comments until September 23, 2011. Dated: September 6, 2011. David J. Kappos, Under Secretary of...

  1. 78 FR 24747 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Science.gov (United States)

    2013-04-26

    ...-27-94, Thomas J. Lynch Trustee, St. Louis, Missouri; David Meiners, St. Louis, Missouri; Elizabeth H... Lesche Engler Fund (J. Curtis Engler), St. Louis, Missouri; David N. Flowers, Greenville, Illinois; Duane... and Marylyn J. Kirkham as Joint Tenants, both of Chesterfield, Missouri; Linda W. Lynch...

  2. Modes of Representation in Cognitive Mapping.

    Science.gov (United States)

    Cohen, Michelle E.; Nodine, Calvin F.

    Recent investigations of the cognitive components of human-environmental interactions owe much to the work of city planner Kevin Lynch, who hypothesized cognitive mapping as a two-way interactive process between individuals and their environment. Lynch identified five elements which individuals used in the construction of cognitive maps,…

  3. Effects of emotions on optimism bias and illusion of control in traffic.

    NARCIS (Netherlands)

    Mesken, J. Hagenzieker, M.P. & Rothengatter, T.

    2005-01-01

    Anger is related to aggression in traffic, which in turn may lead to risky driving (e.g. Lajunen, Parker & Stradling, 1998; Deffenbacher, Huff, Lynch, Oetting & Salvatore, 2000; Parker, Lajunen & Summa!a, 2002; Deffenbacher, Lynch, Filetti, Dahlen & Oetting, 2003). Anger may also lead directly to

  4. Factors Influencing Effectiveness of the Acquisition Career Field Initial Education Course

    Science.gov (United States)

    2006-03-01

    Design Method, New York, Wiley. Eisenberger, Robert; Cummings, Jim; Armeli, Stephen; Lynch, Patrick . (1997). “Perceived organizational support...305-312. Lynch, Patrick D.; Eisenberger, Robert; Armeli, Stephen. (1999). “Perceived organizational support: Inferior versus superior performance...Jum C. (1978) Psychometric Theory, New York, McGraw-Hill. Pillai , Rajnandini; Williams, Ethlyn A. (2004). “Transformational leadership, self

  5. Book Reviews

    Directory of Open Access Journals (Sweden)

    Joann Kovacich

    2013-09-01

    Osage, Patricia and McCall, Mary. Connecting with Socially Isolated Seniors: A Service Provider’s Guide Diane L. Brown Lynch, Caitrin. My Name is Julius: a film about growing old, staying young, and confronting a lifetime of hearing loss Lynch, Caitrin. Retirement on the Line : Age, Work, and Value in an American Factory Anne Velardi

  6. The MLH1 c.1852_1853delinsGC (p.K618A) Variant in Colorectal Cancer : Genetic Association Study in 18,723 Individuals

    NARCIS (Netherlands)

    Abuli, Anna; Bujanda, Luis; Munoz, Jenifer; Buch, Stephan; Schafmayer, Clemens; Maiorana, Maria Valeria; Veneroni, Silvia; van Wezel, Tom; Liu, Tao; Westers, Helga; Esteban-Jurado, Clara; Ocana, Teresa; Pique, Josep M.; Andreu, Montserrat; Jover, Rodrigo; Carracedo, Angel; Xicola, Rosa M.; Llor, Xavier; Castells, Antoni; Dunlop, Malcolm; Hofstra, Robert; Lindblom, Annika; Wijnen, Juul; Peterlongo, Paolo; Hampe, Jochen; Ruiz-Ponte, Clara; Castellvi-Bel, Sergi

    2014-01-01

    Colorectal cancer is one of the most frequent neoplasms and an important cause of mortality in the developed world. Mendelian syndromes account for about 5% of the total burden of CRC, being Lynch syndrome and familial adenomatous polyposis the most common forms. Lynch syndrome tumors develop mainly

  7. Information Operations in Iraq: The Mufsiddoon versus the U.S. and Coalition Forces

    Science.gov (United States)

    2008-04-01

    After firing the weapon, Zarqawi puts the weapon down and walks away to his truck wearing American made sneakers (Reeboks). Maj Gen Lynch points this...burning his hand and the comment by Gen Lynch that Zarqawi is wearing American sneakers drew a lot of laughter and played well in the Iraqi media.31

  8. Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology.

    Science.gov (United States)

    Provenzale, Dawn; Gupta, Samir; Ahnen, Dennis J; Bray, Travis; Cannon, Jamie A; Cooper, Gregory; David, Donald S; Early, Dayna S; Erwin, Deborah; Ford, James M; Giardiello, Francis M; Grady, William; Halverson, Amy L; Hamilton, Stanley R; Hampel, Heather; Ismail, Mohammad K; Klapman, Jason B; Larson, David W; Lazenby, Audrey J; Lynch, Patrick M; Mayer, Robert J; Ness, Reid M; Regenbogen, Scott E; Samadder, Niloy Jewel; Shike, Moshe; Steinbach, Gideon; Weinberg, David; Dwyer, Mary; Darlow, Susan

    2016-08-01

    This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers.

  9. Pleasure, Fun and Flow

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    Through a life long commitment to urban design and urban planning, the legacy of American urban scholar Kevin Lynch is today influential in urban design practice as well as in education. In particular this paper will deal with the way Lynch discussed, saw and analysed the role of urban mobility...... of uninspiring and socially inactive sites for the contemporary mobile urbanite. However, the point about studying urban mobility through the perspective of Lynch is that we may realise that there are (or perhaps should be) other potentials and options. Thus there are two main points to be made in this paper...

  10. B-LYNCH缝合术对前置胎盘产妇剖宫产止血效果及预后的影响%Effects of B-LYNCH sutura on hemostasis and prognosis of puerperae with placenta praevia after caesarean section

    Institute of Scientific and Technical Information of China (English)

    马秀英

    2016-01-01

    目的 探讨B-LYNCH缝合术及Bakri球囊对前置胎盘产妇剖宫产止血效果及预后影响的差异.方法 选择58例前置胎盘产妇为研究对象,随机分成A、B两组,各29例.B组予以Bakri球囊填塞方案,A组采用B-LYNCH缝合方案.对比两组产妇围产期各指标及预后指标差异;行为期12个月随访,比较两组产后并发症发生情况、性生活满意度及子宫切除情况.结果 (1)两组月经恢复时间、经量、月经周期等指标对比均无显著差异(P>0.05);但A组产妇平均术程、术中失血量、术后2h失血量、术后24h失血量、止血时间均显著低于B组(P<0.05);(2)随访中,两组均无子宫缺血、宫腔粘连等并发症发生;A组产后出血率为6.9%,显著低于B组的31.0%(P<0.05);(3)B组术后性生活满意度为65.5%,显著低于A组的93.1%(P<0.05);A组术后子宫切除率显著低于B组(P<0.05).结论 对行剖宫产的前置胎盘产妇予以B-LYNCH缝合方案,术中止血效果确切,可有效改善其术后性生活满意度,降低远期并发症发生风险,值得推广.

  11. 概念现象诠释凯文·林奇《城市意象》中的思维与概念%Concept, Phenomenon and Interpretation The Thinking and Concept of Kevin Lynch's The Image Of The City

    Institute of Scientific and Technical Information of China (English)

    李梦一欣

    2011-01-01

    文章以人思维中的"概念"为起点,从一个新的视角解读凯文·林奇的.通过"概念"表达思维的真实性,展现作者思辨的研究过程;从人的实际经验出发,利用现象而非言语演示概念,并与复杂的现实世界建立密切的联系;通过意象传达概念,在完成整个认知过程的同时达到与读者交流的目的;采用层层概念分步诠释,最终完成复杂概念的推演过程.同时在本文研究过程中明确了理性、真实的言语在"演示"中所起的关键作用.

  12. 验证凯文·林奇"形态核心价值标准理论"——以上海江湾-五角场地区为例%An Examination about Form Value Core Standards Theory from Kevin Lynch--A Case Study of Jiangwan-Wujiaochang Area,Shanghai

    Institute of Scientific and Technical Information of China (English)

    潘斌; 张剑涛; 周俭

    2008-01-01

    作者首先对美国凯文·林奇提出的"空间形态价值标准理论"推导思路与内容做出概述;然后通过调查、分析上海江湾-五角场地区空间形态规划制定及空间建成效果,对凯文·林奇的"形态价值标准理论"进行验证.结果显示,在上海江湾-五角场地区空间生成案例中,林奇的"核心价值标准理论"基本成立.

  13. Black Sex Myth and American Lynch: A Unique Perspective of James Baldwin's Anatomy on Racial Discrimination%黑人性神话与美国私刑——詹姆斯·鲍德温剖析种族歧视的独特视角

    Institute of Scientific and Technical Information of China (English)

    谭惠娟

    2007-01-01

    美国著名黑人作家詹姆斯·鲍德温从小缺乏家庭温暖和母爱,这导致了他成年后对性爱的畸形追求和不可自拔的迷恋,他因此每每注重从"性"的角度来观察和思考包括种族歧视在内的种种人生和社会问题.他认为白人对黑人滥施私刑乃至所有种族矛盾的根源,就在于白人对黑人性能力的恐惧;他还设想性爱可以成为化解种族冲突以及其他社会矛盾的良方,这构成了詹姆斯·鲍德温观察和思考种族歧视问题的独特视角和思路.这篇小说就集中体现了这种思想.

  14. Prokljatõje filmõ i dveri v nikuda / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2007-01-01

    Ameerika režissöör ja maalikunstnik David Lynch esineb 7. novembril kinos Kosmos loenguga "Film, Creativity and Consciousness". Ka filmist "Inland Empire". Eestisse kutsujateks olid Veiko Õunpuu, Rain Tolk ja Taavi Eelmaa

  15. Editorial

    OpenAIRE

    Zinchenko, Yury P.

    2016-01-01

    The current issue of “Psychology in Russia: State of the Art” provides the special section Mathematical learning: New perspectives and challenges, edited by Marina Vasilyeva, associate professor at Lynch School of Education, Boston College (USA).

  16. Metal-plaadid / Sergo Selder

    Index Scriptorium Estoniae

    Selder, Sergo

    2005-01-01

    Uutest heliplaatidest Deftones "B-Sides & Rarities", Metsatöll "Terast mis hangunud me hinge 10218", Horricane "The Lynch-Lawers", "Chimaira", Disturbed "Ten Thousand Fists", Iron Maiden "Death On The Road", Fear Factory "Transgression"

  17. Metal-plaadid / Sergo Selder

    Index Scriptorium Estoniae

    Selder, Sergo

    2005-01-01

    Uutest heliplaatidest Deftones "B-Sides & Rarities", Metsatöll "Terast mis hangunud me hinge 10218", Horricane "The Lynch-Lawers", "Chimaira", Disturbed "Ten Thousand Fists", Iron Maiden "Death On The Road", Fear Factory "Transgression"

  18. 78 FR 66937 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Science.gov (United States)

    2013-11-07

    ... Building Assistance for High Impact HIV Prevention, Funding Opportunity Announcement (FOA) PS14-1403... Impact HIV Prevention'' FOA PS14-1403. Contact Person for More Information: Harriette A. Lynch,...

  19. 77 FR 23 - Prohibitions and Restrictions on Proprietary Trading and Certain Interests in, and Relationships...

    Science.gov (United States)

    2012-01-03

    ... Associate Director, Division of Research and Statistics, (202) 452-3761; David Lynch, Manager, (202) 452... Sandoe, Senior Special Counsel, David Bloom, Branch Chief, or Angela Moudy, Attorney Advisor, Office...

  20. 77 FR 3745 - Establishment of a One-Year Retention Period for Trademark-Related Papers That Have Been Scanned...

    Science.gov (United States)

    2012-01-25

    .... Lynch, Office of the Deputy Commissioner for Trademark Examination Policy, by telephone at (571) 272... after submitting the request to verify entry of the requested changes. Dated: January 17, 2012. David...

  1. 78 FR 68488 - Self-Regulatory Organizations; NYSE MKT LLC; Notice of Filing of Proposed Rule Change Amending...

    Science.gov (United States)

    2013-11-14

    ... activity). \\14\\ See Calvin David Fox, 56 SE.C. 1371, 1376 (2003) (``With respect to a charge that conduct... business-related conduct. See also In the Matter of Merrill Lynch, Pierce, Fenner & Smith...

  2. 76 FR 60582 - Petition for Exemption; Summary of Petition Received

    Science.gov (United States)

    2011-09-29

    ...) 267-7626, or David Staples (202) 267-4058, Office of Rulemaking, Federal Aviation Administration, 800... Washington, DC, on September 23, 2011. Julie Ann Lynch, Acting Director, Office of Rulemaking. Petition...

  3. Culicidae (Diptera del arco sur de la Laguna de Mar Chiquita (Córdoba, Argentina y su importancia sanitaria Culicidae (Diptera from the southern coast of Mar Chiquita Lake (Cordoba, Argentina and their sanitary importance

    Directory of Open Access Journals (Sweden)

    Francisco Ludueña Almeida

    2004-12-01

    Full Text Available Se amplía la lista de veintidos especies de Culicidae citadas para el arco sur de la Laguna de Mar Chiquita a veintiocho. Aedeomyia squamipennis (Lynch Arribalzaga , Culex acharistus Root, Culex chidesteri Dyar, Haemagogus spegazzinii Brèthes, Mansonia titillans (Walker y Psorophora holmbergi Lynch Arribalzaga se citan por primera vez para la región. Se sintetizan los antecedentes relacionados con la importancia sanitaria de los culícidos de la zona.The list of twenty-two species of Culicidae from the southern coast of Mar Chiquita Lake is extended to twenty-eight. Aedeomyia squamipennis (Lynch Arribalzaga , Culex acharistus Root, Culex chidesteri Dyar, Haemagogus spegazzinii Brèthes , Mansonia titillans (Walker and Psorophora holmbergi Lynch Arribalzaga are listed for the first time for the region. The available information on sanitary importance of the culicids of the area is summarized.

  4. Järgmisel nädalal algab Veneetsia filmifestival / Andris Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Andris, 1982-

    2006-01-01

    Tänavune Veneetsia filmifestival toimub 30. augustist 9. septembrini. Kuldlõvile kandideerib 20 filmi, žüriid juhib Catherine Deneuve, elutööpreemia saab David Lynch. Festival algab Brian de Palma filmiga "Must daalia"

  5. Effects of seed fermentation method on seed germination and vigor ...

    African Journals Online (AJOL)

    BERTIN

    2013-11-27

    Nov 27, 2013 ... 3Plant Husbandry and Horticulture Unit, University of Liège - Gembloux Agro Bio Tech. Passage ... Central Africa (Bisognin, 2002; Enujiugha and Ayodele-. Oni, 2003). ... seed fermentation process (Harper and Lynch, 1980;.

  6. IN VITRO STUDY ON INHIBITION OF GLYCOSYLATION OF ...

    African Journals Online (AJOL)

    Administrator

    extract inhibits the binding of glucose to hemoglobin, since at higher concentration of glucose ... nonenzymatic glycosylation also occur in nucleic acids. In the later reaction ..... Raphael, S. S. (1983). Lynch's Medical Laboratory Technology 4th.

  7. Disease: H00543 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available Bergmann C, Fliegauf M, Bruchle NO, Frank V, Olbrich H, Kirschner J, Schermer B, Schmedding I, Kispert A, Kranzlin B, Nurnberg G, Bec...ker C, Grimm T, Girschick G, Lynch SA, Kelehan P, Sender

  8. Järgmisel nädalal algab Veneetsia filmifestival / Andris Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Andris, 1982-

    2006-01-01

    Tänavune Veneetsia filmifestival toimub 30. augustist 9. septembrini. Kuldlõvile kandideerib 20 filmi, žüriid juhib Catherine Deneuve, elutööpreemia saab David Lynch. Festival algab Brian de Palma filmiga "Must daalia"

  9. What Are the Risk Factors for Small Intestine Adenocarcinoma?

    Science.gov (United States)

    ... they are diagnosed is about 60. Smoking and alcohol use Some, but not all, studies have found ... is discussed more in Colorectal Cancer . Hereditary nonpolyposis colorectal cancer (HNPCC) Another name for HNPCC is Lynch syndrome . ...

  10. Prokljatõje filmõ i dveri v nikuda / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2007-01-01

    Ameerika režissöör ja maalikunstnik David Lynch esineb 7. novembril kinos Kosmos loenguga "Film, Creativity and Consciousness". Ka filmist "Inland Empire". Eestisse kutsujateks olid Veiko Õunpuu, Rain Tolk ja Taavi Eelmaa

  11. 75 FR 2853 - False Killer Whale Take Reduction Team Meeting

    Science.gov (United States)

    2010-01-19

    ...)(C) requires that members of TRTs have expertise regarding the conservation or biology of the marine... Lynch, Marine Mammal Commission; Paul Nachtigall, Hawaii Institute of Marine Biology; David Nichols... Meeting AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric...

  12. LALIGENS, Vol.4 (1), January 2015

    African Journals Online (AJOL)

    client

    2015-01-09

    Jan 9, 2015 ... Lynch and Mendelsohn (2014) posit that active listening is an ... features such as stress, intonation, rhythm, loudness and duration, which are absent ..... Finally, it encourages relaxation, using physical techniques and using.

  13. Russian Stance in the Caucasus and the National Security Strategy of Georgia

    Science.gov (United States)

    2005-06-01

    METHODOLOGY Dorff5 suggests conducting strategic analyses on three major levels: System/international level, nation-state level, and individual level. He...2000: Eric Baudelaire, Dov Lynch, “Abkhazia Journal,” Documentaire (2000), http://www.documentaire.com/caucasus/Abkhazia.html (accessed: 01.29.2005...Lynch, D. 2000; Abkhazia, in: Documentaire . Retrieved from: http://www.documentaire.com/caucasus/Abkhazia.html; last accessed: 12.05.2005 Byman, D

  14. Gennemhullede myter:

    DEFF Research Database (Denmark)

    Schubart, Rikke

    2005-01-01

    artikel om redningen af den amerikanske soldat Jessica Lynch og brugen af hende i amerikansk propaganda sammenhæng og om den efterfølgende dekonstruktion af brugen/myten Udgivelsesdato: april......artikel om redningen af den amerikanske soldat Jessica Lynch og brugen af hende i amerikansk propaganda sammenhæng og om den efterfølgende dekonstruktion af brugen/myten Udgivelsesdato: april...

  15. Silk or Spandex : Chinas Problematic One Road, One Belt Plan to Expand its Economic Boundaries as Seen Through the Lens of American, British, and Japanese Experience

    Science.gov (United States)

    2016-04-04

    135. 31 Liza G. Steele and Scott M. Lynch, “The Pursuit of Happiness in China: Individualism, Collectivism, and Subjective Well-Being during...level of consumption, a reduction in the availability of health care, and a significant loss of jobs in certain textile industries suggesting growing...2001): 269-81. Steel, Ronald. Pax Americana. New York: The Viking Press, 1967. Steele, Liza G. and Scott M. Lynch. “The Pursuit of Happiness in

  16. Colorectal cancer screening.

    Science.gov (United States)

    Burt, Randall W; Cannon, Jamie A; David, Donald S; Early, Dayna S; Ford, James M; Giardiello, Francis M; Halverson, Amy L; Hamilton, Stanley R; Hampel, Heather; Ismail, Mohammad K; Jasperson, Kory; Klapman, Jason B; Lazenby, Audrey J; Lynch, Patrick M; Mayer, Robert J; Ness, Reid M; Provenzale, Dawn; Rao, M Sambasiva; Shike, Moshe; Steinbach, Gideon; Terdiman, Jonathan P; Weinberg, David; Dwyer, Mary; Freedman-Cass, Deborah

    2013-12-01

    Mortality from colorectal cancer can be reduced by early diagnosis and by cancer prevention through polypectomy. These NCCN Guidelines for Colorectal Cancer Screening describe various colorectal screening modalities and recommended screening schedules for patients at average or increased risk of developing colorectal cancer. In addition, the guidelines provide recommendations for the management of patients with high-risk colorectal cancer syndromes, including Lynch syndrome. Screening approaches for Lynch syndrome are also described.

  17. Re-defining the Architectural Design Process Through Building a Decision Support Framework for Design with Reused Building Materials and Components

    OpenAIRE

    Ali, Ahmed Kamal

    2012-01-01

    Waste from construction and demolition-building activities is increasing every day.Landfills have almost reached their capacity. When thinking about the negative impact ofdemolishing activities on the environment it becomes very necessary to think aboutreusing and recycling building materials in new construction or perhaps better recyclingour thoughts on how to make use of waste materials. In Kevin Lynch\\'s book, WastingAway, he wrote: "Architects must begin to think about holes in the ground...

  18. The Foundations of Operational Resilience Assessing the Ability to Operate in an Anti-Access/Area Denial (A2/AD) Environment: The Analytical Framework, Lexicon, and Characteristics of the Operational Resilience Analysis Model (ORAM)

    Science.gov (United States)

    2016-07-07

    Force Basing Options in East Asia, MG-1204-AF, 2013, not available to the general public. • Brent Thomas, Mahyar A. Amouzegar, Rachel Costello, Robert ...A. Guffey, Andrew Karode, Christopher Lynch, Kristin F. Lynch, Ken Munson, Chad J. R. Ohlandt, Daniel iv M. Romano, Ricardo Sanchez, Robert S...locations come under attack. 54 chains would likely have to address them. ORAM includes sufficient “ hooks ” and interrelationships that such explorations

  19. Evaluating U.S. Military Engineering Efforts In East Africa

    Science.gov (United States)

    2013-03-01

    V-35. 67 Jefferson P. Marquis, Jennifer D. P. Moroney, Justin Beck, Derek Easton , Scott Hiromoto, David R. Howell, Janet Lewis, Charlotte Lynch...11, 2010), 52-8; Jefferson P. Marquis, Jennifer D. P. Moroney, Justin Beck, Derek Easton , Scott Hiromoto, David R. Howell, Janet Lewis, Charlotte... Easton , Scott Hiromoto, David R. Howell, Janet Lewis, Charlotte Lynch, Michael J. Neumann, Cathryn Quantic Thurston, Developing an Army Strategy for

  20. Design Automation for Streaming Systems

    Science.gov (United States)

    2005-12-16

    Acoustics, Speech and Signal Processing (ICASSP ’92), volume 5, pages 561–564, March 1992. 272 BIBLIOGRAPHY [Gaudiot and Bic, 1991] Jean - Luc Gaudiot and...Bilsen, Marc Engels, Rudy Lauwereins, and Jean Peper- straete. Cyclo-static dataflow. IEEE Transactions on Signal Processing, 44(2):397– 408, February...Lynch and Tuttle, 1987] Nancy A. Lynch and Mark R. Tuttle. Hierarchical correct- ness proofs for distributed algorithms. In Proceedings of the Sixth

  1. A new species of broad-headed eleutherodactylus from the cordillera occidental of Colombia (Amphibia, Leptodactylidae A new species of Broad-Headed Eleutherodactylus from the Cordillera Occidental of Colombia (Amphibia, Leptodactylidae

    Directory of Open Access Journals (Sweden)

    Lynch John D.

    1986-12-01

    Full Text Available The broad-headed eleutherodactyline frogs have been studied by Lynch(1975, 1981. Although frogs of this assembly are easily identified (Lynch,1975, 1976, 1981, the assembly is not a natural group (Lynch, 1986.Recently, Rivero (1984 described a new species, E. sernai, from westernAntioquia, Colombia. Although Rivero associated E. sernai with thebiporcatus group, the species appears to be a member of the sulcatus group(because it possesses the plesiornorphic condition of the mandibular musclesadductors and the trigeminal nerve mandibular ramus. However, this characteristicis not sufficient to place E. sernai within the sulcatus group; theassignment will be defended in a future paper on the osteology of the variousspecies of the group. For the moment, the sulcatus group contains thefollowing species: E. cerasies Lynch, E. cornutus (Jimenez de la Espada,E. helonotus (Lynch, E. ingeri (Cochran and Gain, E. ruizi Lynch, E.sernai Rivero, and E. sulcatus Se describe Eleutherodactylus cadenai sp. nov. de las selvas de la vertiente occidental de la Cordillera Occidental de Colombia (corregimiento .de Murrí, Municipio de Frontino, Antioquia.  La especie parece tener un ancestro común con Eleutherodactylus ingeri de los bosques nublados de la Cordillera Oriental de Colombia y las dos tienen parentescos con Eleutherodactylus ruizi de las cordilleras Central y Occidental de Colombia.

  2. Medical students’ knowledge, attitude, and practice of complementary and alternative medicine: a pre- and post-exposure survey in Majmaah University, Saudi Arabia

    OpenAIRE

    Qureshi, Naseem; AlMansour,Mohammed; AlBedah,Abdullah; AlRukban,Mohammed; Elsubai,Ibrahim; Mohamed,Elsadig; Ahmed,Elolemy; Khalil,Asim; Khalil, Mohamed; Alqaed,Meshari; Almudaiheem,Abdullah; Mahmoud,Waqas; Medani,Khalid

    2015-01-01

    Mohammed Abdullah Al Mansour,1 Abdullah MN Al-Bedah,2 Mohammed Othman AlRukban,3 Ibrahim S Elsubai,2 Elsadiq Yousif Mohamed,4 Ahmed Tawfik El Olemy,2 Asim AH Khalil,2 Mohamed KM Khalil,2 Meshari Saleh Alqaed,2 Abdullah Almudaiheem,2 Waqas Sami Mahmoud,4 Khalid Altohami Medani,4 Naseem Akhtar Qureshi2 1College of Medicine, Majmaah University, Al Majma’ah, 2National Center of Complementary and Alternative Medicine, Ministry of Health, 3Department of Family Medicine and Community Medic...

  3. Detached-Eddy Simulation of Flow Non-Linearity of Fluid-Structural Interactions Using High Order Schemes

    Science.gov (United States)

    2009-05-01

    numbers and achieve high convergence rates for the algebraic Baldwin-Lomax turbulence model. For the Spalart-Allmaras one equation turbulence model...are computed using the LDE scheme and the Roe scheme to compare their performance. Both S-A one equation model and B-L algebraic model are used for...AIAA J., Vol. 28, 1990, pp. 253–262. 182 [113] Rogers, S. E. and Menter, F. R. and Mansour, N. N. and Durbin , P. A. , “A compari- son of turbulence

  4. Support for the Armor Ceramics symposium at the 40th International Conference on Advanced Ceramics and Composites

    Science.gov (United States)

    2016-05-09

    ICACC-S1-P008-2016. Influence of Curvature on High Velocity Impact of SiC/SiC Composites R. Mansour; M. Kannan; M. Presby; G. Morscher; F. Abdi...end type RBSC radiant tube H. Shin; B. Yun; Y. Kim 5:30 PM-8:00 PM ICACC-S1-P025-2016. The Study on Variables of SiC Granule Prepared from Solar...Cholewa-Kowalska 5:30 PM-8:00 PM ICACC-S9-WW-P067-2016. Ceramic foam filter for the filtration of aluminum with different surface chemistrie C

  5. Possible solar control on primary production along the Indian west coast on decadal to centennial timescale

    Digital Repository Service at National Institute of Oceanography (India)

    Kurian, S.; Agnihotri, R.; Borole, D.V.; Naqvi, S.W.A.; Ferreira, A.M.; Vale, C.

    . Naqvi SWA, Narvekar PV, Desa E. 2006c. Coastal biogeochemical processes in the North Indian Ocean (14, S-W). In: The Sea, vol. 14B, edited by Robinson AR and Brink KH, Harvard University Press, pp. 723–781 Qasim SZ, Sen Gupta R. 1981. Environmental... organic matter: organic facies and palynofacies, Chapman & Hall, London, pp. 395-415. Volkman JK, Barrett SM, Blackburn SI, Mansour MP, Sikes EL, Francois G. 1998. Microalgal biomarkers: A review of recent research developments. Organic Geochemistry 29...

  6. Electroless deposition of NiWB alloy on p-type Si(1 0 0) for NiSi contact metallization

    Energy Technology Data Exchange (ETDEWEB)

    Duhin, A. [Department of Physical Electronics, Engineer Faculty, Tel-Aviv University, Ramat-Aviv 69978 (Israel)], E-mail: alla.douhin@gmail.com; Sverdlov, Y. [Department of Physical Electronics, Engineer Faculty, Tel-Aviv University, Ramat-Aviv 69978 (Israel); Feldman, Y. [Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot 76100 (Israel); Shacham-Diamand, Y. [Department of Physical Electronics, Engineer Faculty, Tel-Aviv University, Ramat-Aviv 69978 (Israel)

    2009-10-30

    Recently, we have proposed a novel method to form NiSi contacts using electroless plating of Ni-alloys (NiP, NiWP, NiWB) on p-type Si(1 0 0) modified by aminopropyltriethoxysilane (APTS) activated with Pd-citrate [A. Duhin, Y. Sverdlov, Yishay Feldman, Y. Shacham-Diamand, Microelectron. Eng. 84 (2007) 2506]. In this work we focus on NiWB thin films that were formed by this method. Alkali metal free electroless plating was developed using dimethylamine-borane (DMAB) and tungstatic acid (H{sub 2}WO{sub 4}) as a reducing agent and a source of tungsten ions, respectively. Using this method we succeeded to receive relatively high tungsten concentration (maximum value of 19-21 at%) in the electroless deposited NiWB films with good adhesion to the Si-substrate. In this paper, the advantages of using the APTS activated with Pd-citrate for NiWB alloy deposition on the Si substrate is discussed. The chemically deposited NiWB samples were annealed for 1-2 h in vacuum (<10{sup -6} Torr) forming the silicide layer. The annealing temperatures were 650 deg. C for NiWB alloys. X-ray diffraction (XRD) measurement confirmed the presence of NiSi phase after annealing. In addition the WSi{sub 2} phase was formed. The results are reported and summarized.

  7. Diagnostic Application of hMLH1 Methylation in Hereditary Non-Polyposis Colorectal Cancer

    Directory of Open Access Journals (Sweden)

    Nagahide Matsubara

    2004-01-01

    Full Text Available Colorectal cancer (CRC due to mismatch repair (MMR defect has distinct characteristics among unselected CRCs. These CRCs are biologically less aggressive and, thus, showing better prognosis but less sensitive to the 5FU-based chemotherapy. CRCs with MMR defect derive from both hereditary and sporadic reasons. Germline inactivation of MMR genes (hMLH1, hMSH2, hMSH6, and hPMS2 underlies the hereditary CRC with MMR defect (Lynch syndrome and epigenetic silencing of hMLH1 gene causes the sporadic CRC with MMR defect. Hereditary and sporadic CRC with MMR defect can be detectable by microsatellite instability (MSI test or immunohistochemical analysis among general CRCs. Lynch syndrome can be diagnosed by the clinical criteria or by genetic test to detect pathogenic germline mutations in MMR genes. However, both clinical criteria and genetic test are inadequate for the diagnosis of Lynch syndrome. Since genetic test for the diagnosis of the Lynch syndrome is expensive and not always identify pathogenic germline mutations, effective and inexpensive screening program is desirable. Here we propose a possible application of methylation test combined with MSI or pathological analysis as an effective and a cost-saving new strategy for screening of Lynch syndrome.

  8. Hereditary non-polyposis colorectal cancer: The rise and fall of a confusing term

    Institute of Scientific and Technical Information of China (English)

    Jeremy R Jass

    2006-01-01

    The term Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is a poor descriptor of the syndrome described by Lynch. Over the last decade, the term has been applied to heterogeneous groups of families meeting limited clinical criteria, for example the Amsterdam criteria. It is now apparent that not all Amsterdam criteria-positive families have the Lynch syndrome. The term HNPCC has also been applied to clinical scenarios in which CRCs with DNA microsatellite instability are diagnosed but in which there is no vertical transmission of an altered DNA mismatch repair (MMR) gene. A term that has multiple, mutually incompatible meanings is highly problematic, particularly when it may influence the management of an individual family. The Lynch syndrome is best understood as a hereditary predisposition to malignancy that is explained by a germline mutation in a DNA MMR gene. The diagnosis does not depend in an absolute sense on any particular family pedigree structure or age of onset of malignancy.Families with a strong family history of colorectal cancer that do not have Lynch syndrome have been grouped as 'Familial Colorectal Cancer Type-X'. The first step in characterizing these cancer families is to distinguish them from Lynch syndrome. The term HNPCC no longer serves any useful purpose and should be phased out.

  9. Memory, Identity and Desire: A Psychoanalytic Reading of David Lynch’s Mulholland Drive

    Directory of Open Access Journals (Sweden)

    Murat Akser

    2012-12-01

    Full Text Available This is a reading of David Mulholland Drive through psychoanalytic approach of Lacan from the perspective of formation of fantasy and shifting identities. Lynch constructs his films consciously choosing his themes from the sub(versive/conscious side of human mind. Previous attempts to read Lynch's films are fixed around the idea that Lynch is using film genres to create postmodern pastiches. Mulholland Drive has been analyzed several times from different approaches ranging from gender (Love, 2004, narratology (Lentzner, 2005; McGowan, 2004; Cook, 2011. Elements of film noir, musical, caper films can be identified in Lynch’s films. This detailed textual analysis intends to rationalize Lynch’s narrative structure through Lacanian terms in reference to Zizekian terminology.

  10. Expanding the distribution of two species of mosquitoes (Diptera: Culicidae in Argentina and notes on their bionomics Ampliación de la distribución de dos especies de mosquitos (Diptera: Culicidae en Argentina y notas sobre su bionomía

    Directory of Open Access Journals (Sweden)

    Raúl E. Campos

    2011-12-01

    Full Text Available This paper reports the discovery of the mosquitoes Toxorhynchites haemorrhoidalis (Lynch Arribálzaga and Ochlerotatus milleri Dyar in Corrientes and Buenos Aires provinces respectively, thereby extending the geographical distribution of both species in Argentina.En esta nota, se informa el hallazgo de los mosquitos Toxorhynchites haemorrhoidalis (Lynch Arribálzaga y de Ochlerotatus milleri Dyar en la provincia de Corrientes y Buenos Aires respectivamente; con lo cual se amplía la distribución geográfica de ambas especies en Argentina.

  11. Cataract surgery during active methicillin-resistant Staphylococcus aureus infection

    Directory of Open Access Journals (Sweden)

    Mansour AM

    2014-04-01

    Full Text Available Ahmad M Mansour,1,2 Haytham I Salti11Department of Ophthalmology, American University of Beirut, 2Rafic Hariri University Hospital, Beirut, LebanonAbstract: We present two patients with active, foul-smelling, methicillin-resistant ­Staphylococcus aureus (MRSA wounds of the forehead and sternum following craniotomy or open heart surgery. Both had debilitating cataracts and were told by the infectious diseases team that cataract surgery is very risky. Both underwent sequential bilateral phacoemulsification with no sign of infection. Patients with active MRSA wound infections may safely undergo cataract surgery with additional precautions observed intraoperatively (good wound construction and postoperatively (topical antibiotics and close observation. Banning such surgeries can unnecessarily jeopardize the lifestyles of such patients.Keywords: cataract, infection, methicillin-resistant Staphylococcus aureus, phacoe­mulsification

  12. TG陈年档案

    Institute of Scientific and Technical Information of China (English)

    DAN READ; McLaren Automotive Ltd; Tony

    2014-01-01

    话说1988年意大利大将赛翌日,阿迈凯伦车队成员集合于米兰连尼治机场候机室。由于伦敦航班延误,在同一时间出现于同一地点的大伙儿顿觉无所事事。当天在场的人包括了大老板罗恩·丹尼斯和曼苏尔·欧耶(Mansour Ojjeh)、技术总监戈登·默里和营销总监基赖顿·布朗(Greighton Brown)。

  13. Comment on "Nonlinear refraction measurements of materials using the moiré deflectometry"

    Science.gov (United States)

    Rashidian Vaziri, M. R.

    2015-12-01

    In an influential paper Jamshidi-Ghaleh and Mansour [1] (Opt. Commun. 234 (2004) 419), have reported on a new method for measuring the nonlinear refractive index of materials using the rotational moiré deflectometry technique. In the cited work, the authors apply the ray matrix theory for finding the beam deflection angle on the plane of the first grating in the used geometry. To this end, using the parabolic approximation, the exponential term in the beam irradiance is expanded and retaining the first two resultant terms, the nonlinear sample is treated as a thin lens with a position dependent focal length. In this comment, the effective focal length of the nonlinear sample has been rederived in detail using the Gaussian beam theory and it is shown that it must contain a correction factor. The relative error introduced by ignoring this factor can be as large as 73.5-84.4% in determining the nonlinear refractive index of thin samples.

  14. A revision of the haploporinae nicoll, 1914 (digenea: haploporidae) from mullets (mugilidae): Saccocoelium Looss, 1902.

    Science.gov (United States)

    Blasco-Costa, Isabel; Montero, Francisco E; Gibson, David I; Balbuena, Juan Antonio; Raga, Juan Antonio; Kostadinova, Aneta

    2009-03-01

    Saccocoelium Looss, 1902 is revised and a key to its recognised species is presented. S. obesum Looss, 1902 (type-species) and S. tensum Looss, 1902 are redescribed based on material from Liza spp. (Pisces: Mugilidae) in Spanish Mediterranean and, in the case of the former, Bulgarian Black Sea waters. Two new species, S. cephali n. sp. and S. currani n. sp., are described from Mugil cephalus L. in Spanish Mediterranean waters. S. gohari Ramadan, Saoud, Ashour & Mansour, 1989b is recognised and commented upon. Lecithobotrys helmymohamedi Ramadan, Saoud, Ashour & Mansour, 1989a, S. portsaidensis El-Shahawi, El-Gindy, Imam & Al-Bassel, 1992, S. saoudi El-Shahawi, El-Gindy, Imam & Al-Bassel, 1992, Neosaccocoelium aegyptiacus El-Shahawi, El-Gindy, Imam & Al-Bassel, 1992 are considered to be synonyms of S. tensum and Neosaccocoelium El-Shahawi, El-Gindy, Imam & Al-Bassel, 1992 a synonym of Saccocoelium. S. obesum, S. tensum and the two new species are compared morphometrically and distinguished by univariate and multivariate analyses. Lecithobotrys mugilis Rekharani & Madhavi, 1985 is transferred to Unisaccus Martin, 1973 as U. mugilis (Rekharani & Madhavi, 1985) n. comb., and Lecithobotrys sprenti Martin, 1973 [= Saccocoelium sprenti (Martin, 1973) Overstreet & Curran, 2005] is transferred to Unisaccus as U. sprenti (Martin, 1973) n. comb. S. megasacculum Liu, Wang, Peng, Yu & Yang, 2004 is transferred to Elliptobursa Wu, Lu & Zhu, 1996 as E. megasacculum (Liu, Wang, Peng, Yu & Yang, 2004) n. comb. S. tripathi Dutta, 1995 (syn. Saccocoelium tripathi Datta & Manna, 1998) is considered to be a species inquirenda.

  15. "As a Student, I Do Think that the Learning Effectiveness of Electronic Portfolios Depends, to Quite a Large Extent, on the Attitude of Students!"

    Science.gov (United States)

    Mok, Jane

    2012-01-01

    Lynch and Purnawarman (2004:50) point out that "a solid electronic portfolio can show reflection, evolution of thought and overall professional development". Research shows that electronic portfolio assessment, if implemented thoughtfully, can successfully engage learners in critical thinking and problem solving, promote lifelong…

  16. A Research Program in Computer Technology. Volume 1

    Science.gov (United States)

    1981-08-01

    Kahn, and Bernard Lang . Formal Definition of Ada, Honeywell, Inc. and CII-Honeywell Bull, 1980. 2. Ichbiah, Jean D., et al., Reference Manual for the...14. COMPUTER RESEARCH SUPPORT Technical Staff: Support Staff: Dan Lynch John Metzger Walt Edmison Ray Bates Bill Moore Chloe HoIg Dale Chase Serge

  17. Social Networks in the Tourism Industry: An Investigation of Charleston, South Carolina

    Science.gov (United States)

    Ying, Tianyu

    2010-01-01

    Over the last decade, increasing attention has been given to the networking in the tourism industry (Lynch, 2000; Pavlovich, 2003). The existing literature mainly focuses on the interrelationships among tourism stakeholders at sector level and the structure of the interorganizational networks in tourism industry. However, little research has been…

  18. "Let Me Gather Spring Flowers for a Wreath": Writing about Historical Trauma for Young People in "A Wreath for Emmett Till"

    Science.gov (United States)

    Wissman, Kelly

    2014-01-01

    Marilyn Nelson's book, "A Wreath for Emmett Till", (2005) was named a 2006 Coretta Scott King Honor Book and given the 2006 Printz Honor Award. "A Wreath for Emmett Till" tells the story of a 14-year-old African American boy who was lynched in 1955. Within 15 sonnets accompanied by illustrations by Philippe Lardy, Nelson…

  19. Recommendations to improve identification of hereditary and familial colorectal cancer in Europe

    DEFF Research Database (Denmark)

    Vasen, H F A; Möslein, G; Alonso, A;

    2010-01-01

    Familial colorectal cancer (CRC) accounts for 10-15% of all CRCs. In about 5% of all cases, CRC is associated with a highly penetrant dominant inherited syndrome. The most common inherited form of non-polyposis CRC is the Lynch syndrome which is responsible for about 2-4% of all cases. Surveillan...

  20. Atomic Tailoring of the Solid State Materials for Laser Cryogenic Coolers

    Science.gov (United States)

    2010-04-01

    Graduate Students Mr. Joseph Palma Mr. Zhengle Qiu Mr. Jonathan Lynch Dr. Francisco Bezares Dr. Aras Konjhodzic Dr. Mohamed Aly Mr. David...polishing were performed using mineral oil as a coolant as well the medium for the lapping paste. Polishing invariably used either diamond or

  1. 76 FR 18798 - Maritime Advisory Committee for Occupational Safety and Health (MACOSH)

    Science.gov (United States)

    2011-04-05

    ... Department of Labor's and the OSHA Docket Office's normal business hours, 8:15 a.m. to 4:45 p.m. E.T... Industries George S. Lynch, Jr., International Longshoremen's Association Christopher John McMahon, United... Directorate of Cooperative and State Programs; and presentations on ethics; the Federal Advisory Committee...

  2. Tectonic Scents – Elocutions on the Opium of Maison de Verre

    DEFF Research Database (Denmark)

    Fisker, Anna Marie; Hvejsel, Marie Frier; Tvedebrink, Tenna Doktor Olsen

    2017-01-01

    , hold a sensuous elocution that should be positioned in future architectural research, we ask ourselves? In the essay we pursue this sensuous potential through a semiotic study of the house and the commercial by David Lynch for Yves Saint Laurent’s controversial Opium fragrance filmed in the illusory...

  3. Recommendations to improve identification of hereditary and familial colorectal cancer in Europe

    NARCIS (Netherlands)

    Vasen, H. F. A.; Moeslein, G.; Alonso, A.; Aretz, S.; Bernstein, I.; Bertario, L.; Blanco, I.; Bulow, S.; Burn, J.; Capella, G.; Colas, C.; Engel, C.; Frayling, I.; Rahner, N.; Hes, F. J.; Hodgson, S.; Mecklin, J. -P.; Moller, P.; Myrhoj, T.; Nagengast, F. M.; Parc, Y.; de Leon, M. Ponz; Renkonen-Sinisalo, L.; Sampson, J. R.; Stormorken, A.; Tejpar, S.; Thomas, H. J. W.; Wijnen, J.; Lubinski, J.; Jarvinen, H.; Claes, E.; Heinimann, K.; Karagiannis, J. A.; Lindblom, A.; Dove-Edwin, I.; Mueller, H.

    2010-01-01

    Familial colorectal cancer (CRC) accounts for 10-15% of all CRCs. In about 5% of all cases, CRC is associated with a highly penetrant dominant inherited syndrome. The most common inherited form of non-polyposis CRC is the Lynch syndrome which is responsible for about 2-4% of all cases. Surveillance

  4. Good journalism or peace journalism? – Counterplea by David Loyn

    Directory of Open Access Journals (Sweden)

    David Loyn

    2007-10-01

    Full Text Available In this paper the author responds to the reasoning by Jake Lynch (“Peace journalism and its discontents” and Samuel Peleg (“In defense of peace journalism: A rejoinder”, published in the same issue of conflict & communication online (http://www.cco.regener-online.de/2007_2/inhalt6_2.htm.

  5. A Review of Biological Communication Mechanisms Applicable to Small Autonomous Systems

    Science.gov (United States)

    2010-09-01

    Fishes .......................................................................53 6. Optical 57 6.1 The Mantis Shrimp ...two electric fish (Lynch, 2008). ............................................................57 Figure 59. The Mantis shrimp (Photo: Roy Caldwell...University of California, Berkeley). ......58 Figure 60. The Mantis shrimp can be smaller than a human finger (Marine Specimens Educate

  6. The Global Financial and Economic Crisis: Analysis and Policy Implications

    Science.gov (United States)

    2009-02-20

    losses was the US$5 billion capital injection into Citibank and Merrill Lynch in 2008, which fell to US$2.2 billion before returning to its current...the amount. October 3. Wells Fargo Bank announced a takeover of Wachovia Corp, the fourth-largest U.S. bank. (Previously, Citibank had agreed to take

  7. Disease: H00944 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ran A, Baran W, Hryncewicz-Gwozdz A, Burgdorf W Dowling-Degos disease: case report and review of the literature...Parkinson KE, Kaye V, Lynch PJ Dowling-Degos disease involving the vulva and back: case report and review of the literature. Dermatol Online J 17:1 (2011) ...

  8. Enhancing Defense Support of Civil Authorities within the National Capital Region

    Science.gov (United States)

    2011-04-04

    research. Most notably Colonel Steven Lynch, Provost Marshal, COlonel Marilyn Brew , Deputy Surgeon, and Major Cory Wright, Exercise Planner...popular methods of travel in the United States, as well other developed nations. However, high passenger volume and relativelylow security...tenorist organizations center of gravity , critical capabilities, critical requirements, and critical vulnerabilities. For example, to execute the

  9. Social Networks in the Tourism Industry: An Investigation of Charleston, South Carolina

    Science.gov (United States)

    Ying, Tianyu

    2010-01-01

    Over the last decade, increasing attention has been given to the networking in the tourism industry (Lynch, 2000; Pavlovich, 2003). The existing literature mainly focuses on the interrelationships among tourism stakeholders at sector level and the structure of the interorganizational networks in tourism industry. However, little research has been…

  10. A Serialization Graph Construction for Nested Transactions

    Science.gov (United States)

    1990-02-01

    allowing replacement of entire subtrees of nested activity by single actions as well as the reordering of actions in a history . Also, they do not...systems. 28 [11] N. Lynch, M. Merritt, W. Weihl, and A. Fekete. A theory of atomic transactions. In International Conference on Database Theory, Bruges

  11. The role of limb perfusion studies in the paediatric ischaemic limb

    African Journals Online (AJOL)

    Transmission images of the upper limbs of the same patient as in Figs. 1, 2 and 3. ... specificity of 99%, sensitivity of 96% and positive predictive value of 92%. Normal or .... Huang DB, Price M, Pokorny J, Gabriel KR, Lynch R, Paletta CE.

  12. Evaluating the Significance of CDK2-PELP1 Axis in Tumorigenesis and Hormone Therapy Resistance

    Science.gov (United States)

    2011-02-01

    primary culture. Mol Endocrinol 06;20:3279–92. Caprio JA, Ludlow JW, Lynch D, et al. The product of the retino- stoma susceptibility gene has properties...cell mRNA isolation from frozen prostate biopsy tissue sections. Int J Oncol 26, 1549-1558 (2005) 45. L Rosano, F Spinella, C Di , S Dedhar, MR

  13. Algorithms for Data Sharing, Coordination, and Communication in Dynamic Network Settings

    Science.gov (United States)

    2007-12-03

    Chakraborty, and Nancy Lynch. Clock Synchronization for Wireless Networks. In Teruo Higashino , editor, Principles of Distributed Systems: OPODIS 2004: 8th...Teruo Higashino , editor, Principles of Distributed Systems: OPODIS 2004: 8th International Conference on Principles of Distributed 4 Systems, Grenoble

  14. Applications of GIS and remote sensing for assessing and management of ecologically sensitive habitats from small islands on Chagos Laccadive Archipelago

    Digital Repository Service at National Institute of Oceanography (India)

    Jagtap, T.G.; Nagi, H.M.H.; Kulkarni, V.A.; Savant, S.B.

    Remote Sensing of Inland, Coastal, and Oceanic Waters. eds. by: Frouin, R.J.; Andrefouet, S.; Kawamura, H.; Lynch, M.J.; Pan, D.; Platt, T.(Remote Sensing of Inland, Coastal, and Oceanic Waters Conf.). (Proc. SPIE; 7150). SPIE; USA; 2008; 1...

  15. Phenotype comparison of MLH1 and MSH2 mutation carriers in a cohort of 1,914 individuals undergoing clinical genetic testing in the United States

    NARCIS (Netherlands)

    F. Kastrinos (Fay); E.M. Stoffel (Elena); J. Balmana (Judith); E.W. Steyerberg (Ewout); R. Mercado (Rowena); S. Syngal (Sapna)

    2008-01-01

    textabstractBackground and Aims: Lynch syndrome is caused by germ-line mismatch repair gene mutations. We examined the phenotypic differences between MLH1 and MSH2 gene mutation carriers and whether mutation type (point versus large rearrangement) affected phenotypic expression. Methods: This is a

  16. Body mass index increases risk of colorectal adenomas in men with lunch syndrome: the GEOLynch cohort study

    NARCIS (Netherlands)

    Botma, A.; Nagengast, F.M.; Braem, M.G.M.; Hendriks, J.C.M.; Kleibeuker, J.H.; Vasen, H.F.A.; Kampman, E.

    2010-01-01

    Purpose: High body mass index (BMI) is an established risk factor for sporadic colorectal cancer. Still, the influence of BMI on hereditary colorectal cancer (eg, Lynch syndrome [LS]), is unknown. The objective of this study was to assess whether BMI is associated with colorectal adenoma occurrence

  17. 76 FR 6157 - Meeting of the National Park System Advisory Board

    Science.gov (United States)

    2011-02-03

    ..., Leavenworth, KS. Maine Olson House, Cushing, ME. Minnesota Grand Mound, Koochiching County, MN. Split Rock Light Station, Lake County, MN. New York Woodlawn Cemetery, Bronx, NY. North Dakota Lynch Quarry Site... Indian Agricultural School, Kay County, OK. Platt National Park, Murray County, OK. Oregon Aubrey...

  18. 76 FR 22393 - Records Governing Off-the-Record Communications; Public Notice

    Science.gov (United States)

    2011-04-21

    ... Jim Lynch.\\2\\ Exempt: 1. CP10-477-000 3-28-11 Audrey Platt. 2. CP11-31-000 3-24-11 Gertrude F. Johnson... No. 2079-069 4-8-11 Carolyn Templeton.\\6\\ 10. Project No. 12715-000 3-24-11 David Sinclair.\\7\\...

  19. 77 FR 47619 - Alcoa Power Generating Inc.; Brookfield Smoky Mountain Hydropower LLC; Notice of Application for...

    Science.gov (United States)

    2012-08-09

    ..., Corporate Development and Mr. David R. Poe, Bracewell & Giuliani LLP, 2000 K Street NW., Suite 500, Washington, DC 20006, (202) 828-5800, email david.peo@bgllp.com . Transferee: BAIF U.S. Renewable Power Holdings LLC, 200 Donald Lynch Blvd., Suite 300, Marlboro, MA 01752, Attn: Mr. David Bono, Vice...

  20. A pooled analysis of the outcome of prospective colonoscopic surveillance for familial colorectal cancer

    DEFF Research Database (Denmark)

    Mesher, David; Dove-Edwin, Isis; Sasieni, Peter;

    2014-01-01

    Surveillance guidelines for the management of familial colorectal cancer (FCC), a dominant family history of colorectal cancer in which the polyposis syndromes and Lynch syndrome have been excluded, are not firmly established. The outcome of colonoscopic surveillance is studied using data from six...

  1. 'Right-to-Work' Laws and Economic Development in Oklahoma. Briefing Paper.

    Science.gov (United States)

    Mishel, Lawrence, Ed.

    The bulk of this position paper consists of statements in opposition to a September 2001 referendum on adopting 'right-to-work' (RTW) legislation in Oklahoma. The statements are by Joan Fitzgerald, William Sschweke, Raymond Hogler, Steven Shulman, Stephan Weiler, Ann Markusen, Robert G. Lynch, David R. Howell, James Galbraith, Colin Gordon, Wim…

  2. Test Review: "Test of Language Development-Intermediate" by D. D. Hammill and P. L. Newcomer

    Science.gov (United States)

    Carmichael, Jessica A.; Fraccaro, Rebecca L.; Nordstokke, David W.

    2014-01-01

    Oral language skills are important to consider in school psychology practice, as they are directly tied to many areas of academic functioning. For example, research has demonstrated that oral language skills in early elementary school predict reading comprehension in later grades (Kendeou, van den Broek, White, & Lynch, 2009). With a…

  3. Beliefs about Cancer and Diet among Those Considering Genetic Testing for Colon Cancer

    Science.gov (United States)

    Palmquist, Aunchalee E. L.; Upton, Rachel; Lee, Seungjin; Panter, Abby T.; Hadley, Don W.; Koehly, Laura M.

    2011-01-01

    Objective: To assess beliefs about the role of diet in cancer prevention among individuals considering genetic testing for Lynch Syndrome. Design: Family-centered, cascade recruitment; baseline assessment of a longitudinal study. Setting: Clinical research setting. Participants: Participants were 390 persons, ages 18 and older, including persons…

  4. Davidid tahavad lennata / Mari Peegel

    Index Scriptorium Estoniae

    Peegel, Mari, 1978-

    2010-01-01

    Uuest Saksamaa dokumentaalfilmist "David Wants to Fly", kus režissöör David Sieveking uurib transtsendentaalse meditatsiooni ärisaladusi. TM-ist teeb filmi ka USA režissöör David Lynch, kes 2007. aastal jõudis oma TM-i reklaamiva turneega ka Tallinna

  5. Pop / Andri Riid

    Index Scriptorium Estoniae

    Riid, Andri, 1972-

    2005-01-01

    Heliplaatidest: The Darkness "One Way Ticket to Hell... and Back", Peven Everett "Latest Craze (Part 1)", David Branner "Certified", Eminem "Curtain Call: The Hits", Horricane "The Lynch-Lawyers", Wilco "Kicking Television. Live in Chicago", The Mars Volta "Scab Dates", The Roots "Home Grown! The Beginners Guide To Understanding The Roots Volume 1-2"

  6. Eestisse tuleb filmimaailma suurnimi

    Index Scriptorium Estoniae

    2007-01-01

    Ameerika režissöör ja maalikunstnik David Lynch esineb 7. novembril kinos Kosmos loenguga, külastab Von Krahli teatrit ja võibolla kohtub ka president Toomas Hendrik Ilvesega. Siia kutsujateks olid Veiko Õunpuu, Rain Tolk ja Taavi Eelmaa. Kohtumiseks Eesti presidendiga on legendaarne lavastaja ise soovi avaldanud

  7. Molecular characterization of alpha 1- and alpha 2-adrenoceptors.

    Science.gov (United States)

    Harrison, J K; Pearson, W R; Lynch, K R

    1991-02-01

    Three 'alpha 1-adrenoceptors' and three 'alpha 2-adrenoceptors' have now been cloned. How closely do these receptors match the native receptors that have been identified pharmacologically? What are the properties of these receptors, and how do they relate to other members of the cationic amine receptor family? Kevin Lynch and his colleagues discuss these questions in this review.

  8. Itaalia piiskopid kurjustavad Cannes'i festivali filmi peale / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2002-01-01

    Festivali programmi valitud Marco Bellocchio "Usutund" ("L'ora di religione") on Itaalia katoliiklaste juhtide poolt hukka mõistetud kui usku teotav teos. 15. mail algava festivali avab komöödia "Lõpp Hollywoodiga" ("Hollywood Ending"). Ameerika režissöör David Lynch on valitud juhtima Cannesì filmifestivali žüriid

  9. Disease: H00212 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00212 Acrodermatitis enteropathica (AEZ) Acrodermatitis enteropathica is an autoso...acterized by intermittent simultaneous occurrence of diarrhea and dermatitis with failure to thrive. Inherit...90629 Maverakis E, Fung MA, Lynch PJ, Draznin M, Michael DJ, Ruben B, Fazel N Acrodermatitis enteropathica a...209 Sehgal VN, Jain S Acrodermatitis enteropathica. Clin Dermatol 18:745-8 (2000) ...

  10. Scientific Representation and Science Learning

    Science.gov (United States)

    Matta, Corrado

    2014-01-01

    In this article I examine three examples of philosophical theories of scientific representation with the aim of assessing which of these is a good candidate for a philosophical theory of scientific representation in science learning. The three candidate theories are Giere's intentional approach, Suárez's inferential approach and Lynch and…

  11. 76 FR 66361 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Science.gov (United States)

    2011-10-26

    ... SONJA KARIN LYNCH HIRAO HIROKAZU HO JASON HON SUM HO SALENA CHI KIT HOLLENSTEIN PETER HOLLENSTEIN URSULA... MICHAEL N MUSE RODNEY CHADWICK NA EDWARD YOON NADRAG KARIN NADRAG ROLF PETER NARWANI AMIT ARJAN NEWMAN... OKHAI LEYLA JIHAN ONG JASMINE ANGIE OTHON-LEVIN AURA PALMER EDWARD LEWIS PAN ANDY KUO-AN PAN THOMAS...

  12. Reference: 642 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available nal of biological chemistry Bravo Janis E|Cahoon Edgar B|Chen Ming|Dunn Teresa M|Jaworski Jan G|Lynch Dani...el V|Markham Jonathan E|Mulcahy Brendan J|Richardson Christopher G|Tsegaye Yoseph

  13. Loss of PTEN as a Predictive Biomarker of Response to Lithium Chloride, A Potential Targeted Treatment for Breast Cancer

    Science.gov (United States)

    2013-11-01

    2004;350:2129–39. 10. Sequist LV , Bell DW, Lynch TJ, Haber DA. Molecular predictors of response to epidermal growth factor receptor antagonists in non...SY, Gonen M, Kim HJ, Michor F, Polyak K. Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype

  14. Latent Scope Bias in Categorization

    Science.gov (United States)

    2014-01-01

    Stangor, Lynch, Duan, & Glass, 1992; Tajfel , Billig, Bundy, & Claude, 1971), as well as broader aspects of judgment and decision making (for a review, see...Psychology, 207–218. Tajfel , H., Billig, M. G., Bundy, R. P., & Claude, F. (1971). Social categorization and inter- group behavior. European Journal of

  15. Ore. Community Schools Show Staying Power

    Science.gov (United States)

    Samuels, Christina A.

    2012-01-01

    For Lynch View Elementary, a K-5 school in suburban Portland, the school day doesn't end when the bell rings at 2:22 p.m. As one of 64 "community schools" in Multnomah County, the school also provides homework assistance, academic enrichment, free breakfast and dinner for students, a weekly food pantry, a host site for local medical…

  16. Hate Prejudice and Racism.

    Science.gov (United States)

    Kleg, Milton

    This book provides a comprehensive overview of the problems created by prejudiced attitudes, racist beliefs, and acts of discrimination from the casual racial or ethnic joke to the unrestrained violence of a lynch mob. It addresses such topics as the nature of ethnicity, stereotyping, aggression, and hate groups and individuals who promote ethnic…

  17. Mi Lengua: Spanish as a Heritage Language in the United States.

    Science.gov (United States)

    Roca, Ana, Ed.; Colombi, M. Cecilia, Ed.

    This collection of papers includes the following: (1) "Insights from Research and Practice in Spanish as a Heritage Language" (M. Cecilia Colombi and Ana Roca); (2) "Toward a Theory of Heritage Language Acquisition: Spanish in the United States" (Andrew Lynch); (3) "Profiles of SNS Students in the Twenty-First Century:…

  18. [DNA-based diagnosis of hereditary tumour predisposition

    NARCIS (Netherlands)

    Menko, F.H.; Ligtenberg, M.J.L.; Brouwer, T.; Hahn, D.E.; Ausems, M.G.E.M.

    2007-01-01

    Of all forms of cancer, approximately 5% are caused by factors leading to a strong genetic predisposition. DNA diagnosis is currently used in families with hereditary tumour syndromes, such as familial adenomatous polyposis, hereditary non-polyposis colorectal carcinoma (Lynch syndrome), and heredit

  19. Black Feminism and "Race Uplift," 1890-1900. Working Paper.

    Science.gov (United States)

    Perkins, Linda Marie

    In spite of lack of support from white women, educated black women concentrated their efforts on better conditions for the uneducated and the poorer among them during the late 19th century. Their primary concerns were education and employment opportunities, suffrage, the defense of black female morality, and the condemnation of lynching. The…

  20. Letter to President Harry Truman about the Murder of Harry T. Moore

    Science.gov (United States)

    Jones, Megan

    2011-01-01

    In late December of 1951, a news story out of Mims, Florida, shocked the nation. The story contained elements of prejudice, discrimination, injustice, lynching, rape, bombings, and murder. The story not only made headlines across the country, but also the world. On the evening of December 25, a bomb was placed under the floor joists of the bedroom…

  1. A note on fairness in I/O automata

    NARCIS (Netherlands)

    Romijn, J.M.T.; Vaandrager, F.W.

    1995-01-01

    Notions of weak and strong fairness are studied in the setting of the I/O automaton model of Lynch & Tuttle. The concept of a fair I/O automaton is introduced and it is shown that a fair I/O automaton paired with the set of its fair executions is a live I/O automaton provided that (1) in each reacha

  2. [Reconstructive investigations and identification measures in unknown soldiers of the Second World War].

    Science.gov (United States)

    Jopp-van Well, Eilin; Gehl, Axel; Säring, Dennis; Amling, Michael; Hahn, Michael; Sperhake, Jan; Augustin, Christa; Krebs, Oliver; Püschel, Klaus

    2016-01-01

    The article reports on the exhumation and identification of unknown soldiers from the Second World War. With the help of medicolegal investigation and reconstruction methods an American pilot presumably murdered by a shot to the head (lynch law) and an interned Italian soldier could be identified after about 70 years and brought back home.

  3. Notes on the taxonomy of some Glassfrogs from the Andes of Peru and Ecuador (Amphibia: Centrolenidae

    Directory of Open Access Journals (Sweden)

    Diego F. Cisneros-Heredia

    2014-01-01

    Full Text Available We present new information on several species of centrolenid frogs from Ecuador and Peru that justify the placement of Centrolene fernandoi Duellman and Schulte as a junior synonym of Centrolenella audax Lynch and Duellman; Centrolenella puyoensis Flores & McDiarmid as a synonym of Centrolenella mariae Duellman & Toft; and Cochranella tangarana Duellman & Schulte as a synonym of Cochranella saxiscandens Duellman & Schulte.

  4. Effects of Procedural Content and Task Repetition on Accuracy and Fluency in an EFL Context

    Science.gov (United States)

    Patanasorn, Chomraj

    2010-01-01

    Task-supported language teaching can help provide L2 learners communicative practice in EFL contexts. Additionally, it has been suggested that repetition of tasks can help learners develop their accuracy and fluency (Bygate, 2001; Gass, Mackey, Fernandez, & Alvarez-Torres, 1999; Lynch & Maclean, 2000). The purposes of the study were to investigate…

  5. Itaalia piiskopid kurjustavad Cannes'i festivali filmi peale / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2002-01-01

    Festivali programmi valitud Marco Bellocchio "Usutund" ("L'ora di religione") on Itaalia katoliiklaste juhtide poolt hukka mõistetud kui usku teotav teos. 15. mail algava festivali avab komöödia "Lõpp Hollywoodiga" ("Hollywood Ending"). Ameerika režissöör David Lynch on valitud juhtima Cannesì filmifestivali žüriid

  6. Possible Criteria for Evaluating Shakycam.

    Science.gov (United States)

    Gutenko, Gregory

    The pressure to produce products assures thoughtless imitation and replication in video production. As J. Lynch (1984) observed of the early music video industry, "they borrow the techniques of Dada, Surrealism, and abstract film, and as K. Dieckmann (1985) concurs, the "commercialized industry takes up avant-garde practices to sell…

  7. A Stand-Alone Information System for Small Air Force Hospital Laboratories.

    Science.gov (United States)

    1986-01-01

    1 November 1984): 171-172. 3. Becker, Brenda L. "The Impact of DRGs on New Jersey Labs." Medical Laboratory Observer 16 (January, 1984): 30-41. 4...Inwood, Martin J.; Mellor, Leslie D.; Sergovich, F.; Spencer , Frank; and Thomson, Sam. Lynch’s Medical Laboratory Technology. 3rd ed. Philadelphia: W

  8. Effects of Procedural Content and Task Repetition on Accuracy and Fluency in an EFL Context

    Science.gov (United States)

    Patanasorn, Chomraj

    2010-01-01

    Task-supported language teaching can help provide L2 learners communicative practice in EFL contexts. Additionally, it has been suggested that repetition of tasks can help learners develop their accuracy and fluency (Bygate, 2001; Gass, Mackey, Fernandez, & Alvarez-Torres, 1999; Lynch & Maclean, 2000). The purposes of the study were to investigate…

  9. Collaboration between School, Family, and Occupational Therapy Coaches to Restore Oral Feeding Skills in a Young Child

    Science.gov (United States)

    Drobnyk, Wendy; Rocco, Karen

    2011-01-01

    Boston College Campus School (BCCS) is a private, non-profit, publicly funded special education school within the Lynch School of Education on the campus of Boston College. BCCS occupational therapists serve students between the ages of 3 and 21 who have severe, multiple challenges. Occasionally they partner with community schools to assist…

  10. Optimizing and Validating a Brief Assessment for Identifying Children of Service Members at Risk for Psychological Health Problems Following Parent Deployment

    Science.gov (United States)

    2015-07-01

    Applied Psychosocial Measurement,1, 385-401. Rocissano, L., Slade, A., & Lynch, V. (1987). Dyadic synchrony and toddler compliance. Developmental...properties of the PTSD Checklist (PCL-C, PCL-S, PCL-M, PCL-PR). In B. H. Stamm (Ed.), Measurement of stress, trauma , and adaptation (pp. 250–252). Lutherville, MD: Sidran Foundation & Press. 10

  11. An Analysis of Measures Used to Evaluate the Air Force Critical Item Program

    Science.gov (United States)

    1991-09-01

    would especially like to thank the assistance of Mr. Luis Correa, Mr. Ed ii Kroutsdorfer, and Mr. Cristopher Lynch. I would also like to thank the efforts...Methods (3rd Edition). Homewood: Irwin, 1985. 19. Fine, Charles H. and Evan L. Porteus. "Dynamic Process Improvement," Operations Research 37: 580-591

  12. A Study of the Sensitivity of the Greenland Sea Acoustic Tomography

    Science.gov (United States)

    1989-12-01

    Bushong , 1987), and surface waves (Lynch et al, 1987). In the future, monitoring of large-scale ocean dyramics on a global basis may be achieved using...34Numerical Applications of a Formalism for Geophysical Inverse Problems", Geophys. J. R. Astron. Soc., Vol. 13, pp. 247-76, 1967. Bushong , P.J., "Tomographic

  13. 77 FR 59004 - Membership of the Senior Executive Service Standing Performance Review Boards

    Science.gov (United States)

    2012-09-25

    ... LAUNDERING SECTION. CARROLL, OVIE DIRECTOR, CYBERCRIME LABORATORY, COMPUTER CRIME AND INTELLECTUAL PROPERTY SECTION. CARWILE, P. KEVIN CHIEF, CAPITAL CASE UNIT. LYNCH JR., JOHN T CHIEF, COMPUTER CRIME, AND.... RODGERS, JANICE M DIRECTOR, DEPARTMENTAL ETHICS OFFICE. TOSCANO JR., RICHARD A DIRECTOR, EQUAL...

  14. The Importance of Older Family Members in Providing Social Resources and Promoting Cancer Screening in Families with a Hereditary Cancer Syndrome

    Science.gov (United States)

    Ashida, Sato; Hadley, Donald W.; Goergen, Andrea F.; Skapinsky, Kaley F.; Devlin, Hillary C.; Koehly, Laura M.

    2011-01-01

    Purpose: This study evaluates the role of older family members as providers of social resources within familial network systems affected by an inherited cancer susceptibility syndrome. Design and Methods: Respondents who previously participated in a study that involved genetic counseling and testing for Lynch syndrome and their family network…

  15. Special Libraries of New York City.

    Science.gov (United States)

    Special Libraries, 1989

    1989-01-01

    Describes the facilities, collections, and services of the following special libraries in New York City: Shea and Gould Library; American Foundation for the Blind; Brooklyn Museum; Merrill Lynch Capital Markets Library; Public Relations of American Information Center; Port Authority of New York and New Jersey; and Brooklyn Public Library Business…

  16. Cooperative Manipulation on the Water Using a Swarm of Autonomous Tugboats

    Science.gov (United States)

    2008-05-01

    Lynch. Locally controllable manipulation by stable pushing. IEEE Transactions on Robotics and Automation, pages 318–327, 1999. [13] R. Murray, Z. Li, and...nipulators. IEEE Transactions on Robotics and Automation, 18(1):94 – 103, 2002. [25] H.G. Tanner, A. Jadbabaie, and G.J. Pappas. Stable flocking of mobile

  17. Molecular aspects of HNPCC and identification of mutation carriers

    NARCIS (Netherlands)

    Niessen, Renée Cecil

    2007-01-01

    Hereditary nonpolyposis colorectal cancer (HNPCC) - also referred to as Lynch syndrome - is an autosomal dominantly inherited disorder of cancer susceptibility with high penetrance (80-85%). It is one of the most common inherited cancer syndromes identified in humans so far. In typical HNPCC familie

  18. It should be fair to criticize even noble ideas – Counterplea by Thomas Hanitzsch

    Directory of Open Access Journals (Sweden)

    Thomas Hanitzsch

    2007-10-01

    Full Text Available In this paper the author responds to the reasoning by Jake Lynch (“Peace journalism and its discontents” and Samuel Peleg (“In defense of peace journalism: A rejoinder”, published in the same issue of conflict & communication online (http://www.cco.regener-online.de/2007_2/inhalt6_2.htm.

  19. Marilyn Nelson: Poetic Justice

    Science.gov (United States)

    Pierpont, Katherine

    2006-01-01

    This article features some of the books written by Marilyn Nelson. Here, the author discusses how she has written a children's book of poetry about lynching, entitled "A Wreath for Emmitt Till." The author discusses how her books for children honor and memorialize history-changing African Americans. Among other things, the author discusses some of…

  20. Shortened time interval between colorectal cancer diagnosis and risk testing for hereditary colorectal cancer is not related to higher psychological distress

    NARCIS (Netherlands)

    Landsbergen, K.M.; Prins, J.B.; Brunner, H.G.; Hoogerbrugge, N.

    2011-01-01

    Current diagnostic practices have shortened the interval between colorectal cancer (CRC) diagnosis and genetic analysis for Lynch syndrome by MSI-testing. We studied the relation of time between MSI-testing since CRC diagnosis (MSI-CRC interval) and psychological distress. We performed a

  1. Interface Input/Output Automata: Splitting Assumptions from Guarantees

    DEFF Research Database (Denmark)

    Larsen, Kim Guldstrand; Nyman, Ulrik; Wasowski, Andrzej

    2006-01-01

    We propose a new look at one of the most fundamental types of behavioral interfaces: discrete time specifications of communication---directly related to the work of de Alfaro and Henzinger [3]. Our framework is concerned with distributed non-blocking asynchronous systems in the style of Lynch's \\...

  2. Collaboration between School, Family, and Occupational Therapy Coaches to Restore Oral Feeding Skills in a Young Child

    Science.gov (United States)

    Drobnyk, Wendy; Rocco, Karen

    2011-01-01

    Boston College Campus School (BCCS) is a private, non-profit, publicly funded special education school within the Lynch School of Education on the campus of Boston College. BCCS occupational therapists serve students between the ages of 3 and 21 who have severe, multiple challenges. Occasionally they partner with community schools to assist…

  3. Optical and Radio Remote Sensing of Space Plasma Turbulence

    Science.gov (United States)

    2008-03-31

    Respondents should be aware that notwithstanding any other provision of law , no person shall be subject to any penalty for failing to comply with a collection...528540. Lynch, K.A., R.L. Arnoldy, P.M. Kintner, and J.L. Vago , Electron distribution function Behavior during localized transverse ion acceleration

  4. Kuldlõvi võitis üllatusena Hiina film tammi ehitamisest / A. L.

    Index Scriptorium Estoniae

    A. L.

    2006-01-01

    Veneetsia filmifestivali parima filmi peaauhind Kuldlõvi läks Hiina režissööri Jia Zhang-Ke filmile "Vaikelu" ("Dong"). Parima näitleja Coppa Volpi said Helen Mirren ja Ben Affleck, elutööauhinna sai režissöör David Lynch

  5. By Staying Together, Two Genes Keep the Motor Running.

    Science.gov (United States)

    Zhulin, Igor B

    2017-02-07

    In this issue of Structure, Lynch et al. (2017) reveal that the interaction between two key proteins in the bacterial flagellar motor results in a shared structural domain. This unusual arrangement keeps the corresponding genes together through the course of evolution. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. We Hate Ashley

    Science.gov (United States)

    Willard, Nancy

    2008-01-01

    Two Oregon students create a racist profile on a social networking site, with cartoons about lynching and racist language. Other students link to the profile and post ugly, racist comments. Teachers report that many of the school's minority students are frightened. In another instance, several high school students create a "We Hate…

  7. Regulation of MLH1 mRNA and protein expression by promoter methylation in primary colorectal cancer

    DEFF Research Database (Denmark)

    Jensen, Lars Henrik; Rasmussen, Anders Aamann; Byriel, Lene;

    2013-01-01

    In colorectal cancer MLH1 deficiency causes microsatellite instability, which is relevant for the patient's prognosis and treatment, and its putative heredity. Dysfunction of MLH1 is caused by sporadic gene promoter hypermethylation or by hereditary mutations as seen in Lynch Syndrome. The aim...

  8. The Millennium Cohort: A 21-Year Contribution to the Understanding of Military and Veterans’ Health

    Science.gov (United States)

    2009-12-10

    Jacobson, MPH; Kelly Jones; Cynthia LeardMann, MPH; Travis Leleu; Gordon Lynch; Jamie McGrew; Amanda Pietrucha, MPH; Teresa Powell, MS; Donald...MAJ Bonilla , Dr. Joan Hall, and Dr. Kate Nassauer, MOMRP; COL Karl Friedl and Dr. Richard Satava, MRMC; Dr. Charles Hoge, WRAIR; Dr. Susan Proctor and

  9. Syndromic Gastric Polyps : At the Crossroads of Genetic and Environmental Cancer Predisposition

    NARCIS (Netherlands)

    Brosens, Lodewijk A A; Giardiello, Francis M; Offerhaus, G Johan; Montgomery, Elizabeth A

    2016-01-01

    Gastric polyps occur in 1-4 % of patients undergoing gastroscopy. Although most are sporadic, some gastric polyps are part of an underlying hereditary syndrome. Gastric polyps can be seen in each of the well-known gastrointestinal polyposis syndromes, but also in Lynch syndrome and in several rare n

  10. Easy-to-use online referral test detects most patients with a high familial risk of colorectal cancer

    NARCIS (Netherlands)

    Dekker, N.; Hermens, R.P.M.G.; Mensenkamp, A.R.; Zelst-Stams, W.A.G. van; Hoogerbrugge, N.

    2014-01-01

    AIM: Currently only 12-30% of individuals with a high risk of Lynch syndrome, the most common hereditary colorectal cancer (CRC) syndrome, are referred for genetic counselling. We assessed the sensitivity, usability and user experiences of a new online referral test aimed at improving referral of hi

  11. A Database to Support the Interpretation of Human Mismatch Repair Gene Variants

    NARCIS (Netherlands)

    Ou, Jianghua; Niessen, Renee C.; Vonk, Jan; Westers, Helga; Hofstra, Robert M. W.; Sijmons, Rolf H.

    2008-01-01

    Germline mutations in the mismatch repair (MMR) genes MLH1, MSH2, MSH6, or PMS2 can cause Lynch syndrome. This syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is an autosomal dominantly-inherited disorder predominantly characterized by colorectal and endometrial cancer. Tr

  12. Mi Lengua: Spanish as a Heritage Language in the United States.

    Science.gov (United States)

    Roca, Ana, Ed.; Colombi, M. Cecilia, Ed.

    This collection of papers includes the following: (1) "Insights from Research and Practice in Spanish as a Heritage Language" (M. Cecilia Colombi and Ana Roca); (2) "Toward a Theory of Heritage Language Acquisition: Spanish in the United States" (Andrew Lynch); (3) "Profiles of SNS Students in the Twenty-First Century:…

  13. Chinese Investment in U.S. Aviation

    Science.gov (United States)

    2017-01-01

    Group • Ronald Epstein, senior equity analyst, Bank of America Merrill Lynch • Sash Tusa, defense analyst, Agency Partners, United Kingdom • Joe Borich...Shanghai Development Banks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 Shanghai Municipal Economic...Development Bank CEPREI China Electronic Product Reliability and Environmental Test Research Institute CFIUS Committee on Foreign Investment in the United

  14. Kuldlõvi võitis üllatusena Hiina film tammi ehitamisest / A. L.

    Index Scriptorium Estoniae

    A. L.

    2006-01-01

    Veneetsia filmifestivali parima filmi peaauhind Kuldlõvi läks Hiina režissööri Jia Zhang-Ke filmile "Vaikelu" ("Dong"). Parima näitleja Coppa Volpi said Helen Mirren ja Ben Affleck, elutööauhinna sai režissöör David Lynch

  15. Modeling Edge Effects of Tillage Erosion

    Science.gov (United States)

    Tillage erosion has been recognized as an important factor in redistribution of soil over time and in the development of morphological changes within agricultural fields. Field borders, fences, and vegetated strips that interrupt soil fluxes lead to the creation topographic discontinuities or lynche...

  16. Filling in the Blanks: They Say, I Say, and the Persistence of Formalism

    Science.gov (United States)

    Lynch-Biniek, Amy

    2009-01-01

    Amy Lynch-Biniek begins by introducing popular yet controversial concepts presented in the Gerald Graff and Cathy Birkenstein's "They Say / I Say: The Moves That Matter in Academic Writing" (NY: Norton & Company, 2006). As stated in the book's introduction, the goal of Graff and Birkenstein's text is "to demystify academic…

  17. Scientific Representation and Science Learning

    Science.gov (United States)

    Matta, Corrado

    2014-01-01

    In this article I examine three examples of philosophical theories of scientific representation with the aim of assessing which of these is a good candidate for a philosophical theory of scientific representation in science learning. The three candidate theories are Giere's intentional approach, Suárez's inferential approach and Lynch and…

  18. Davidid tahavad lennata / Mari Peegel

    Index Scriptorium Estoniae

    Peegel, Mari, 1978-

    2010-01-01

    Uuest Saksamaa dokumentaalfilmist "David Wants to Fly", kus režissöör David Sieveking uurib transtsendentaalse meditatsiooni ärisaladusi. TM-ist teeb filmi ka USA režissöör David Lynch, kes 2007. aastal jõudis oma TM-i reklaamiva turneega ka Tallinna

  19. Bagatellid : maailm / Ivo Heinloo

    Index Scriptorium Estoniae

    Heinloo, Ivo

    2011-01-01

    Muusikasõnumeid mujalt maailmast: Romantilist muusikat Silvio Berlusconilt. WOMEXi maailmamuusika auhind Hugh Masekelale. keith Jarreti Brasiilia kontsert vormus plaadiks. Jagati filmimuusika aihindu. David Lynch debüteerib muusikuna. Lahkus Pete Rugolo. Norra kõigi aegade parim plaat valitud

  20. 76 FR 71344 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Science.gov (United States)

    2011-11-17

    ... Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company The notificants listed below have applied under the Change in Bank Control Act (12 U.S.C. 1817(j)) and Sec. 225.41 of the..., Pennsylvania. 2. W. Kirk Wycoff, Ira M. Lubert, and James J. Lynch, all of Philadelphia,...

  1. 76 FR 48862 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Science.gov (United States)

    2011-08-09

    ... Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company The notificants listed below have applied under the Change in Bank Control Act (12 U.S.C. 1817(j)) and Sec. 225.41 of the... Financial Mangers, LLC; Ira M. Lubert; W. Kirk Wycoff; and James J. Lynch, all of Philadelphia,...

  2. 76 FR 40365 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Science.gov (United States)

    2011-07-08

    ... Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company The notificants listed below have applied under the Change in Bank Control Act (12 U.S.C. 1817(j)) and Sec. 225.41 of the....; and Ira M. Lubert, W. Kirk Wycoff, and James J. Lynch, all of Philadelphia, Pennsylvania, to...

  3. An Interface Theory for Input/Output Automata

    DEFF Research Database (Denmark)

    Larsen, Kim Guldstrand; Nyman, Ulrik; Wasowski, Andrzej

    Building on the theory of interface automata by de~Alfaro and Henzinger we design an interface language for Lynch's Input/Output Automata, a popular formalism used in the development of distributed asynchronous systems, not addressed by previous interface research. We introduce an explicit separa...

  4. Letter to President Harry Truman about the Murder of Harry T. Moore

    Science.gov (United States)

    Jones, Megan

    2011-01-01

    In late December of 1951, a news story out of Mims, Florida, shocked the nation. The story contained elements of prejudice, discrimination, injustice, lynching, rape, bombings, and murder. The story not only made headlines across the country, but also the world. On the evening of December 25, a bomb was placed under the floor joists of the bedroom…

  5. PEDIATRIC OPHTHALMLOGY AND STRABISMUS

    African Journals Online (AJOL)

    and self-esteem.[2] In Minnesota, strabismus was .... The transmission is autosomal dominant since no generation is skipped as shown by the .... Mendicino ME, Lynch MG, Drack A, Beck AD, Harbin T, Pollard Z, et al. Long-term surgical and ...

  6. Deflecting the Political in the Visual Images of Execution and the Death Penalty Debate

    Science.gov (United States)

    George, Diana; Shoos, Diane

    2005-01-01

    Examining a range of visual images of executions, both legal (the executions of convicted murderers) and extralegal (the lynchings of innocent African Americans), in still photographs and in Hollywood films, the authors suggest that while such images may flatten and neutralize the popular debates and politics surrounding the issues, this is not…

  7. 77 FR 52107 - Air Traffic Data in the Possession of Government Contractors

    Science.gov (United States)

    2012-08-28

    ...: A. Background On August 3, 2012, the Pilot's Bill of Rights, Public Law 112-153, was enacted. The... requirements of the Pilot's Bill of Rights. Issued in Washington, DC, on August 22, 2012. Peter J. Lynch...: Federal Aviation Administration (FAA), DOT. ACTION: Notice. SUMMARY: The recently enacted Pilot's Bill of...

  8. Beliefs about Cancer and Diet among Those Considering Genetic Testing for Colon Cancer

    Science.gov (United States)

    Palmquist, Aunchalee E. L.; Upton, Rachel; Lee, Seungjin; Panter, Abby T.; Hadley, Don W.; Koehly, Laura M.

    2011-01-01

    Objective: To assess beliefs about the role of diet in cancer prevention among individuals considering genetic testing for Lynch Syndrome. Design: Family-centered, cascade recruitment; baseline assessment of a longitudinal study. Setting: Clinical research setting. Participants: Participants were 390 persons, ages 18 and older, including persons…

  9. Diagnosis of Constitutional Mismatch Repair-Deficiency Syndrome Based on Microsatellite Instability and Lymphocyte Tolerance to Methylating Agents

    DEFF Research Database (Denmark)

    Bodo, Sahra; Colas, Chrystelle; Buhard, Olivier

    2015-01-01

    BACKGROUND & AIMS: Patients with bi-allelic germline mutations in mismatch repair (MMR) genes (MLH1, MSH2, MSH6, or PMS2) develop a rare but severe variant of Lynch syndrome called constitutional MMR deficiency (CMMRD). This syndrome is characterized by early-onset colorectal cancers, lymphomas o...

  10. Final Technical Report for contract N00014-89-J-3179 (University of California)

    Science.gov (United States)

    1993-01-01

    circuit. In Eichenbaum , H. and Davis, J. L., editors, Olfaction as a model system for computational neuroscience. MIT Press, Cambridge, Mass. Lynch...pages 605-615. Speidel, S., Kolesar, R., and Martin , S. (1993). Olfactory cortex model applied to the classification of darpa acoustic data features

  11. Pop / Andri Riid

    Index Scriptorium Estoniae

    Riid, Andri, 1972-

    2005-01-01

    Heliplaatidest: The Darkness "One Way Ticket to Hell... and Back", Peven Everett "Latest Craze (Part 1)", David Branner "Certified", Eminem "Curtain Call: The Hits", Horricane "The Lynch-Lawyers", Wilco "Kicking Television. Live in Chicago", The Mars Volta "Scab Dates", The Roots "Home Grown! The Beginners Guide To Understanding The Roots Volume 1-2"

  12. The effect of monensin on milk production, milk urea nitrogen and ...

    African Journals Online (AJOL)

    Unknown

    Keywords: Monensin, milk production, milk composition, blood urea nitrogen, milk urea nitrogen, cow. *Present ..... Feedstuffs 68, 14. ... Lowe, L.B., Ball, G.J., Carruthers, V.R., Dobos, R.C., Lynch, G.A., Moate, P.R., Poole, P.R. & Valentine,.

  13. Examining the Moderating Role of Family Cohesion on the Relationship between Witnessed Community Violence and Delinquency in a National Sample of Adolescents

    Science.gov (United States)

    Barr, Simone C.; Hanson, Rochelle; Begle, Angela M.; Kilpatrick, Dean G.; Saunders, Benjamin; Resnick, Heidi; Amstadter, Ananda

    2012-01-01

    Witnessed community violence has been linked to a number of internalizing and externalizing problems in adolescents. Guided by Cicchetti and Lynch's (1993) ecological-transactional model, this study aimed to examine the impact that family-level factors had on negative outcomes associated with witnessed community violence. Using a nationally…

  14. B-lynch缝合及改良B-lynch缝合术在剖宫产术中止血的应用

    Institute of Scientific and Technical Information of China (English)

    魏红; 张金梅

    2013-01-01

      Objective To summarize the Rehabilitation Hospital of Shaanxi Province, the use of B-Lynch sutura and improved B-Lynch sutura effective in reducing the experience of postpartum hemorrhage. Methods Implementation of B-Lynch suture method in our hospital from April 2010 to November 2012, 31 cases of cesarean section surgery appears difficult to control uterine bleeding or significant bleeding tendency in patients and improved B-Lynch sutura. Results Made good hemostatic effect results in 31 cases of cesarean section, no case of hysterectomy and postoperative complications. Conclusion strengthen the preoperative, intraoperative assessment, timely preventive implementation of B-Lynch sutura bleeding tendency, can be effective in reducing postpartum bleeding.%  目的总结陕西省康复医院运用B-lynch缝合及改良B-lynch缝合术有效减少产后出血的经验。方法对2010年4月-2012年11月间31例剖宫产术,因术中出现难以控制子宫出血或有明显出血倾向的患者实行B-lynch缝合及改良B-lynch缝合术。结果31例剖宫产术中均取得良好止血效果,无一例子宫切除及术后并发症。结论加强术前、术中的评估,对有出血倾向者及时预防性实行B-lynch缝合术,即可有效减少产后出血。

  15. The Air Is on Fire

    Directory of Open Access Journals (Sweden)

    Thérèse Guilbert

    2008-05-01

    Full Text Available C’est un grand néon rose fluorescent accroché à la façade de verre de la Fondation Cartier qui affiche le nom de David Lynch et annonce l’exposition The Air Is on Fire (du 3 mars au 27 mai 2007. La forme froide des lettres intriquées évoque l’architecture industrielle qui fascine tant l’artiste et, sans surprise, le modèle du néon sera à chercher dans la collection de ses dessins soigneux. Car on connaissait David Lynch le cinéaste, mais voilà le plasticien : peintures et aquarelles, sculptu...

  16. Hereditary colorectal cancer diagnostics

    DEFF Research Database (Denmark)

    Klarskov, Louise; Holck, Susanne; Bernstein, Inge

    2012-01-01

    BackgroundThe hereditary non-polyposis colorectal cancer (HNPCC) subset of tumours can broadly be divided into tumours caused by an underlying mismatch-repair gene mutation, referred to as Lynch syndrome, and those that develop in families with similar patterns of heredity but without disease......-predisposing germline mismatch repair mutations, referred to as familial colorectal cancer type X (FCCTX). Recognition of HNPCC-associated colorectal cancers is central since surveillance programmes effectively reduce morbidity and mortality. The characteristic morphological features linked to Lynch syndrome can aid...... in the identification of this subset, whereas the possibility to use morphological features as an indicator of FCCTX is uncertain.Objective and methodsTo perform a detailed morphological evaluation of HNPCC-associated colorectal cancers and demonstrate significant differences between tumours associated with FCCTX...

  17. Information preserving image compression for archiving NMR images.

    Science.gov (United States)

    Li, C C; Gokmen, M; Hirschman, A D; Wang, Y

    1991-01-01

    This paper presents a result on information preserving compression of NMR images for the archiving purpose. Both Lynch-Davisson coding and linear predictive coding have been studied. For NMR images of 256 x 256 x 12 resolution, the Lynch-Davisson coding with a block size of 64 as applied to prediction error sequences in the Gray code bit planes of each image gave an average compression ratio of 2.3:1 for 14 testing images. The predictive coding with a third order linear predictor and the Huffman encoding of the prediction error gave an average compression ratio of 3.1:1 for 54 images under test, while the maximum compression ratio achieved was 3.8:1. This result is one step further toward the improvement, albeit small, of the information preserving image compression for medical applications.

  18. Functional examination of MLH1, MSH2, and MSH6 intronic mutations identified in Danish colorectal cancer patients

    DEFF Research Database (Denmark)

    Petersen, Sanne M; Dandanell, Mette; Rasmussen, Lene J

    2013-01-01

    Germ-line mutations in the DNA mismatch repair genes MLH1, MSH2, and MSH6 predispose to the development of colorectal cancer (Lynch syndrome or hereditary nonpolyposis colorectal cancer). These mutations include disease-causing frame-shift, nonsense, and splicing mutations as well as large genomi...... rearrangements. However, a large number of mutations, including missense, silent, and intronic variants, are classified as variants of unknown clinical significance.......Germ-line mutations in the DNA mismatch repair genes MLH1, MSH2, and MSH6 predispose to the development of colorectal cancer (Lynch syndrome or hereditary nonpolyposis colorectal cancer). These mutations include disease-causing frame-shift, nonsense, and splicing mutations as well as large genomic...

  19. Inferring Deleterious-Mutation Parameters in Natural Daphnia Populations

    Directory of Open Access Journals (Sweden)

    Deng Hong-Wen

    1998-01-01

    Full Text Available Deng and Lynch (1, 2 proposed to characterize deleterious genomic mutations from changes in the mean and genetic variance of fitness traits upon selfing in outcrossing populations. Such observations can be readily acquired in cyclical parthenogens. Selfing and life-table experiments were performed for two such Daphnia populations. A significant inbreeding depression and an increase of genetic variance for all traits analyzed were observed. Deng and Lynch's (2 procedures were employed to estimate the genomic mutation rate (U, mean dominance coefficient ( , mean selection coefficient ( , and scaled genomic mutational variance ( . On average, , , and (^ indicates an estimate are 0.84, 0.30, 0.14 and 4.6E-4 respectively. For the true values, the and are lower bounds, and and upper bounds.

  20. MSH6 Mutations are Frequent in Hereditary Nonpolyposis Colorectal Cancer Families With Normal pMSH6 Expression as Detected by Immunohistochemistry

    DEFF Research Database (Denmark)

    Okkels, Henrik; Larsen, K.L.; Thorlacius-Ussing, O.;

    2012-01-01

    INTRODUCTION:: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant condition accounting for 2% to 4% of all colorectal cancer cases worldwide. Families with germ line mutations in 1 of 6 mismatch repair genes are known as Lynch syndrome families. The largest number...... of mutations has been detected in the mismatch repair genes MLH1 and MSH2, but several mutations in MSH6 have also been demonstrated. AIM:: Whether HNPCC families are screened for mutations in mismatch repair genes often relies on their immunohistochemical profile. The aim of the present study was to evaluate...... this approach in Lynch families carrying mutations in MSH6. MATERIALS AND METHODS:: Results of the screening of the MSH6 gene in HNPCC families were compared with those obtained on immunohistochemical protein analysis. RESULTS:: In 56 (7%) of 815 families, at least 1 MSH6 mutation, 23 definitively pathogenic...

  1. The powerless starchitect: How Zaha Hadid became the first person working on the Al-Wakrah stadium that actually did die

    Directory of Open Access Journals (Sweden)

    Frank van der Hoeven

    2016-05-01

    Full Text Available Starchitect Zaha Hadid won the bid to design one of the planned stadiums for the 2022 FIFA World Cup event in Qatar. Her design for the Al-Wakrah stadium became the centrepiece of a discussion on the role that starchitects play in society. That debate reached a boiling point in August 2014, and resulted in a digital lynching party that sheds serious doubts on the ethics and professionalism of architectural critics and journalists alike.

  2. Naftariigid tõmbavad hinnapidurit / Erik Aru

    Index Scriptorium Estoniae

    Aru, Erik

    2008-01-01

    Investeerimispanga Merrill Lynch tooraineanalüüsi juht Merril Francisco Blanchi prognoosib, et nafta hind langeb madalaimale tasemele 2009. a. esimeses pooles ning alates juunist hakkab hind tõusma. IEA prognoosib, et naftatarbimise kasv aeglustub aastatel 2008-2013 vaid keskmiselt 1,2% võrra. OPEC, kes on viimase kahe kuu jooksul juba vähendanud naftatootmist, võib vastu võtta järjekordse otsuse naftatootmist kärpida. Vt. samas: Naftaspioonide maailm

  3. The Next Wave. Volume 19, Number 2

    Science.gov (United States)

    2012-01-01

    Engineering. 1981; 16. DOI: 10.1109/TSE. 1981.230844 [25] Canetti R. Universally composable security: A new paradigm for cryptographic protocols. In...Computing. I987;2(3):117 126. DOI: 10.1007/BF01782 130] Canetti R, Cheung I., Kaynar DK, Liskov M, Lynch N \\. Pereira O Segala R. Time hounded task...efficiency. In: Canetti R, editor. Theory of Cryptography (Proceedings of the Fifth Theory of Cryptography Conference; Mar 2008; New York, \\ V ) 1

  4. Catching the Big Fish : Idea is Like Fish%创意就像鱼——评《钩大鱼》

    Institute of Scientific and Technical Information of China (English)

    王婷

    2009-01-01

    @@ 思想前卫的大卫·林奇(David Lynch)1946年生于美国蒙大拿,费城贫民区的动荡生活让他见识了层生活的血腥与残酷,其独特奇异的随笔在一定程度上也是他成长的一个浓缩的小结.

  5. Heterotopia on Screen- Blue Velvet (1986

    Directory of Open Access Journals (Sweden)

    Filimon Eliza Claudia

    2014-03-01

    Full Text Available Based on a framework consisting of postmodern theories of heterotopias, spatial pastiche, schizophrenic temporality and postmodern speed, this paper seeks to identify cinematic features in the works of the American director David Lynch, which exemplify time and space in postmodernism. Michel Foucault's theory of space will trigger the whole problematic of the time-space relation. This is followed by a discussion of Fredric Jameson's concepts of spatial pastiche and schizophrenic temporality and of the involute interaction between the two

  6. Lesbis sustineo! Naiad press authors remember Barbara Grier.

    Science.gov (United States)

    Cantrell, Jaime

    2014-01-01

    Drawing from semi-structured interviews with some of Naiad Press's most celebrated women, including Katherine V. Forrest, Barbara's supervising editor at Naiad from 1983-1993; Sheila Ortiz Taylor, author of what is considered by many to be the first lesbian novel with a Chicana heroine; and the incomparable Lee Lynch, this work aims to sustain an ongoing remembrance of Grier's life and work by encouraging memory exploration--a symphonic blending of the printed and spoken word.

  7. Neurobiology of Learning and Memory: Modulation and Mechanisms

    Science.gov (United States)

    1988-08-01

    Granger, R. (1988). Analysis and simulation of a simple cor- tical network. The Psychology of Learning and Motivation, 22, in press. Standing, L. (1973...R.H. and Schlimmer, J.C. The Computation of Contingency in Clas- sical Conditioning. The Psychology of ’ Learning and Motivation 20: 137-192, 1986...simulation of a simple cortical network. The Psychology of Learning and Motivation, in press. Lynch, G., Granger, R.H., and Larson, J. Some possible functions

  8. Conference on the Neurobiology of Learning and Memory (2nd).

    Science.gov (United States)

    1986-05-30

    the Brain: Animal and Human Cognitive Processes (Norman M. Weinberger, James L. McGaugh, and Gary Lynch, Editors) was published (Guil- ford Press) in...humans. The evidence reviewed strongly suggests that, in humans as well as * animals , different forms of learning may be based on different neural...Retardation Res. Ctr. University of California Los Angeles, CA 90024 & Centro de Investigaciones en Fisiologia Celular, UNAM E-4 PLASTICITY OF

  9. Spatial Perception and Cognition Review. Considering Geotechnologies as Urban Planning Strategy

    OpenAIRE

    Júnia Borges; Camila Zyngier; Karen Lourenço; Jonatha Santos

    2014-01-01

    This article proposes a review of the spatial cognition and perception principles, referring to the definition proposed by Cullen and Lynch, through the geotechnology tools. It presents a case study to be analyzed through Geographical Information Systems (GIS), 3D Modeling, Spatial Analysis and Data Base Structure. This proposition presents reflections about the concepts and values of the early foundations of the spatial perception and cognition theories as a base to promote participative pla...

  10. Saugus River and Tributaries, Lynn, Malden, Revere and Saugus, Massachusetts. Flood Damage Reduction. Volume 7. Appendix J. Feasibility Study and EIS/EIR Comments and Responses. Section A.

    Science.gov (United States)

    1989-12-01

    TRAPELO ROAD Paul Murphl WALTHAM, MASSACHUSETTS, 02254-9149 AMr CmmO o,, Lou DropSi T-.VWe DEAR M.WILSON: TOM MCC.A0ft FAavrdal S , ye, Joe DiDomiciao...Shepardson EOEA/MEPA Unit Philps wLighting QxnJUL 13A L 0mm1Lvm. MA01 I CUDDY, LYNCH, MANZI & BIXBY AToaNm AT LAw ONs FINANCL. CENT= BosTON, MAuScACsKUs

  11. Journal of Rehabilitation Research and Development, Spring 1991. Volume 28, Number 2

    Science.gov (United States)

    1991-01-01

    1968. 16. Lynch MP, Eilers RE, Oiler DK, Urbano RC, Pero PJ: 27. Weisenberger JM, Broadstone SM, Saunders FA: Multisensory narrative tracking by a...55 01, Telex 697033F, Fax (33.1) Medart International: First World Congress on Arts 39 63 56 38 Medicine - Arts and Medicine, Medicine for Artists... Arts as Medicine, The Hague, The Netherlands September 18-20, 1991 Contact: Hoboken Congress Organisation, Erasmus Dynamic Axial Fixation Com-se

  12. 16S rRNA Gene Pyrosequencing of Reference and Clinical Samples and Investigation of the Temperature Stability of MicroBiome Profiles

    Science.gov (United States)

    2014-09-16

    Brodie EL, Lynch SV, Kolter R: Comparative analyses of the bacterial microbiota of the human nostril and oropharynx. mBio 2010, 1(3):e00129-10 doi...Three readily available mock bacterial community materials and two commercial extraction techniques, Qiagen DNeasy and MO BIO PowerSoil DNA...quantitative PCR and amplification of region V3 to V1. Swabs spiked with mock bacterial community cells and clinical oropharyngeal swabs were incubated

  13. Peace Journalism - i dansk dækning af internationale konflikter

    OpenAIRE

    Lind, Katrine; Seidenfaden, Johan

    2006-01-01

    #The manner in which the Danish media covered the invasion and the war in Iraq has been criticized from several sides. American and British media have similarly been subject to critical investigation because of their war coverage. As a solution to the apparent problems in reporting international conflicts two journalists, Jake Lynch and Annabel McGoldrick, created a practise-oriented concept known as Peace Journalism. The concept is based on Peace and Conflict Research theory as it is lai...

  14. Silk or Spandex?: China’s Problematic One Road, One Belt Plan to Expand its Economic Boundaries as Seen Through the Lens of American, British, and Japanese Experience

    Science.gov (United States)

    2016-06-14

    Happiness in China: Individualism, Collectivism, and Subjective Well-Being during China’s Economic and Social Transformation,” Social Indicators...pointing out that China’s poorest 40% have experienced a substantial decrease in the level of consumption, a reduction in the availability of health ...Viking Press, 1967. Steele, Liza G. and Scott M. Lynch. “The Pursuit of Happiness in China: Individualism, Collectivism, and Subjective Well-Being

  15. Prevalence of hereditary nonpolyposis colorectal cancer in patients with colorectal cancer in Iran: a systematic review

    Directory of Open Access Journals (Sweden)

    Abbas Esmaeilzadeh

    2016-07-01

    Full Text Available Introduction: Colorectal cancer (CRC is the third leading cause of cancer deaths in the world, and hereditary factors and family history are responsible for the incidence and development of the disease in 20 to 30% of cases. Lynch syndrome, or hereditary nonpolyposis colorectal cancer (HNPCC, is the most common hereditary form of CRC that is inherited in an autosomal dominant manner. This study consisted of a systematic literature review of research articles that described the prevalence of HNPCC in Iranian patients with CRC. Methods: A systematic literature search was conducted in the PubMed, Scopus, IranMedex, and Google Scholar databases to identify relevant articles that describe HNPCC or Lynch syndrome in patients with CRC in Iran. For this purpose, a keyword search of the following terms was employed: (((Hereditary nonpolyposis colorectal cancer OR HNPCC OR Lynch syndrome AND (colorectal cancer OR familial colorectal cancer OR colon cancer OR rectal cancer OR bowel cancer AND IRAN. All eligible documents were collected, and the desired data were qualitatively analyzed.Result: Of the 67 articles that were found via the initial database search, only 12 were deemed to be of relevance to the current study. These articles included a total population of 3237 and this sample was selected and qualitatively analyzed. The findings of the review revealed that the frequency of mutation in MLH1, MSH2, PMS2, and MSH6 genes varied between 23.1% and 62.5% among the studied families. This indicated that HNPCC is linked with up to 5.5% of the total cases of colorectal cancers in Iran.Conclusion: The results of this study revealed that the hereditary form of HNPCC or Lynch syndrome is significantly high among patients with CRC in Iran

  16. Angular Random Walk Estimation of a Time-Domain Switching Micromachined Gyroscope

    Science.gov (United States)

    2016-10-19

    11 R. Juhl. 2016. “CTSM-R - Continuous Time Stochastic Modelling for R.”Available online at http://ctsm.info/. Accessed April 17, 2016. 12 D. Lynch...on Instrumentation and Measurement, vol. 57, no. 1, pp. 140–149. 15 S. S. Rao. 2007. Vibration of Continuous Systems. John Wiley & Sons, Inc...7269 INITIAL DISTRIBUTION 84300 Library (1) 85300 Archive/Stock (1) 55250 P. Swanson (1) 71730 A. Sabater (1) Defense Technical Information

  17. Topological X-Rays Revisited

    Science.gov (United States)

    Lynch, Mark

    2012-01-01

    We continue our study of topological X-rays begun in Lynch ["Topological X-rays and MRI's," iJMEST 33(3) (2002), pp. 389-392]. We modify our definition of a topological magnetic resonance imaging and give an affirmative answer to the question posed there: Can we identify a closed set in a box by defining X-rays to probe the interior and without…

  18. Signalling properties of lysophosphatidic acid.

    Science.gov (United States)

    Durieux, M E; Lynch, K R

    1993-06-01

    Lysophosphatidic acid (LPA) is the simplest natural phospholipid, primarily known as a membrane component and metabolic intermediate. However, a remarkable variety of biological effects of this compound have come to light, seemingly pointing to an additional role for LPA as a signalling molecule. In this review, Marcel Durieux and Kevin Lynch integrate the recent information that indicates that LPA could be an intercellular messenger, possibly acting through a G protein-coupled receptor, and with a role in cell growth and motility.

  19. Tegaserod (Novartis).

    Science.gov (United States)

    Norman, Peter

    2002-02-01

    Novartis has developed and launched tegaserod, an aminoguanidine indole 5-HT(4) receptor partial agonist, for the potential treatment of constipation-predominant irritable bowel syndrome (IBS) [286804], [311514] and other functional GI disorders, such as gastroesophageal reflux disease (GERD), chronic constipation and functional dyspepsia [342937], [362853]. It was launched in Mexico for IBS in July 2001 [416879] and in the Czech Republic, Venezuela and Colombia by October 2001. By this time, the product had also been approved in Switzerland [427419]. In September 2001, launch of the product for GERD, chronic constipation and functional dyspepsia was expected after 2003 [422828]; later in October 2001, the launch dates for the latter two indications were anticipated for 2004 [427419], [431614]. In December 2000, Merrill Lynch predicted sales of SFr 150 million in 2001, rising to SFr 612 million in 2004, larger than the September 2000 predictions of SFr 120 million in 2001 rising to SFr 378 million in 2004 [394812], [383742]. Later in February 2001, Merrill Lynch predicted sales of SFr 150 million in 2001 rising to SFr 785 million per annum in 2005, assuming a US launch during the third quarter of 2001 [411704]. Following the withdrawal of the MAA and then the rejection of tegaserod's NDA by the FDA, in June 2001, Merrill Lynch progressively revised its 2005 sales forecasts from SFr 1.1 billion to SFr 950 million and then to SFr 375 million [422783]. In June 2001, Merrill Lynch also suggested that there was a significant possibility that tegaserod would never reach the market. In August 2001, Deutsche Bank estimated sales of SFr 200 million in 2004 and SFr 550 million in 2005 [422674]. Analysts at Credit Suisse predicted in October 2001, that there was only a three in ten chance that tegaserod would ever reach a major market following the issuance of a 'non-approvable' letter by the FDA in June 2001. They predicted sales of SFr 5 million in 2001, rising to SFr 325

  20. Measuring Social Privilege Attitudes Using a Situational Judgment Test: Validation of the Diversity Engagement Test (DivET)

    Science.gov (United States)

    2012-07-28

    privilege: The concept of social privilege. Journal of Multicultural Counseling and Development, 33, 243–255. Feldman, J. M., & Lynch, J. G. (1988...research related to training military Equal Opportunity Advisors (EOAs). EOAs inform and counsel unit commanders and Service members regarding...divergent validity: the Multicultural Attitude Scale (MCAS) and the short form of the Marlowe-Crowne Social Desirability Scale (MCSD). The MCAS

  1. Investigation of Optical Fibers for Coherent Anti-Stokes Raman Scattering (CARS) Spectroscopy in Reacting Flows (Postprint)

    Science.gov (United States)

    2012-03-01

    notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not...OF ABSTRACT: SAR 18. NUMBER OF PAGES 22 19a. NAME OF RESPONSIBLE PERSON (Monitor) a. REPORT Unclassified b. ABSTRACT Unclassified c...Seeger of the University of Erlangen- Nuremberg , Prof. Margaret M. Murnane of the University of Colorado/JILA, and Dr. Hans Stauffer and Ms. Amy Lynch

  2. Comment to the note "Counting of discrete Rossby/drift wave resonant triads", arXiv:1309.0405

    CERN Document Server

    Kartashov, A

    2013-01-01

    The main purpose of this note is clarify the following misunderstanding apparent in the note arXiv:1309.0405 by M. Bustamante, U. Hayat, P. Lynch, B. Quinn; [1]: the authors erroneously assume that in the manuscript arXiv:1307.8272 by A. Kartashov and E. Kartashova, [2], resonant triads with real amplitudes are counted whereas it can be seen explicitly from the form of dynamical system that wave amplitudes are complex.

  3. Objective Versus Subjective Military Pilot Selection Methods in the United States of America

    Science.gov (United States)

    2015-12-14

    or supplied the drawings, specifications, or other data does not license the holder or any other person or corporation or convey any rights or...COL JOHN P. LYNCH COL LAURA TORRES-REYES Chief, Aerospace Consult Service Division Chair, Aerospace...1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any

  4. Summer Prostate Cancer Research Training Program

    Science.gov (United States)

    2016-07-01

    UU 19b. TELEPHONE NUMBER (include area code) Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std . Z39.18 david-lubaroff@uiowa.edu 32 Lubaroff, p. 4... Delaware State U./Nebraska graduate school Neja White 2009 working in healthcare none at this time working in healthcare Akede, Theresa 2010...science Ihejirika, Patrick 2011 graduate school univ of delaware graduate school Lynch, Candice 2011 graduate school Nova Southeastern Univ

  5. Naftariigid tõmbavad hinnapidurit / Erik Aru

    Index Scriptorium Estoniae

    Aru, Erik

    2008-01-01

    Investeerimispanga Merrill Lynch tooraineanalüüsi juht Merril Francisco Blanchi prognoosib, et nafta hind langeb madalaimale tasemele 2009. a. esimeses pooles ning alates juunist hakkab hind tõusma. IEA prognoosib, et naftatarbimise kasv aeglustub aastatel 2008-2013 vaid keskmiselt 1,2% võrra. OPEC, kes on viimase kahe kuu jooksul juba vähendanud naftatootmist, võib vastu võtta järjekordse otsuse naftatootmist kärpida. Vt. samas: Naftaspioonide maailm

  6. Antidepressant-associated sexual dysfunction: impact, effects, and treatment

    OpenAIRE

    Agnes Higgins; Michael Nash; Lynch, Aileen M.

    2010-01-01

    Agnes Higgins, Michael Nash, Aileen M LynchSchool of Nursing and Midwifery Studies, Trinity College Dublin, Dublin, IrelandAbstract: Sexual dysfunction is a common side effect of antidepressants and can have significant impact on the person’s quality of life, relationships, mental health, and recovery. The reported incidence of sexual dysfunction associated with antidepressant medication varies considerably between studies, making it difficult to estimate the exact incidence or prev...

  7. Preliminary study on the presence of aflatoxin B1 in feeds for lactating cows sampled in the Parmigiano Reggiano production area

    Directory of Open Access Journals (Sweden)

    A. Zaghini

    2010-01-01

    Full Text Available Toxigenic fungi can affect the most common and relevant crops during the growth, harvest, or storage steps and produce toxic substances known as mycotoxins. Among the reasons for which these substances contaminate approximately 25% of the world’s food crops (Lawlor and Lynch, 2001 are prominently inappropriate agricultural and storage practices, intercontinental shipping, as well as environmental and climatic conditions (relative humidity and temperature (Moss, 1991.

  8. Multiphase Ceramics for Mechanical and Structural Reliability at Low and Elevated Temperatures

    Science.gov (United States)

    1994-06-30

    example of PSZ uses MgO as the stabilizer. The second class. ’ tetragonal zirconia polycrystals’ ( TZP ). consists entirely (or nearly so) of tetragonal ...Mazdiyasni, C. T. Lynch and J. S. Smith II, " Cubic Phase Stabilization of Translucent Yttria- Zirconia at Very Low Temperatures", J. Am. Ceram. Soc., 50[10...toughness and Iracture strength of the composite increased. Similar results were reported by 8 French. et. al. 1992). for the cubic zirconia + alumina

  9. Coalition Modeling in Humanitarian Assistance Operations

    Science.gov (United States)

    2006-03-01

    Generally, the high cost of military operations, reduced military budgets after the cold war, global economies, and the need for international legitimacy...addition, there has been a global increase in civil/ethnic strife which cause complex emergency (Lynch: 4). Furthermore, since these emergencies generally...notional scenario has been scaled back for demonstration purposes. These scenarios are solved using Xpress by Dash Optimization which is a commercial

  10. Identifying risk factors for postpartum depressive symptoms: the importance of social support, self-efficacy, and emotion regulation

    OpenAIRE

    Haga, Silje Marie

    2011-01-01

    As many as 10-15% of new mothers experience severe emotional distress frequently labelled postpartum depression (PPD) (Brockington, 2004; O’Hara & Swain, 1996). The consequences of postpartum depressive symptoms can be serious for the mother, her child and family. Indeed, women who suffer from PPD are less capable of carrying out maternal duties, which may influence the child’s cognitive, and socioemotional development (Goodman, Brogan, Lynch & Shielding, 1993), as well as the infant’s attach...

  11. Computation of the Circular Error Probable (CEP) and Confidence Intervals in Bombing Tests

    Science.gov (United States)

    2007-11-01

    22134 NORTH CAROLINA STATE UNIVERSITY RALEIGH NC 27695-8203 DR EDWARD WEGMAN 1 CENTER FOR COMPUTATIONAL SCIENCES DR JAMES D LYNCH GEORGE MASON...UNIVERSITY DEPT OF STATISTICS 157 SCIENCE AND TECHNOLOGY II BUILDING UNIVERSITY OF SOUTH CAROLINA FAIRFAX VA 22030 COLUMBIA SC 29208 DR JAMES GENTLE DR JAMES R...MICHIGAN STATE UNIVERSITY IOWA STATE UNIVEIRSITY EAST LANSING Ml 48824 102 SNEDECOR HALL AMES IA 5001 1-1210 DR ENSOR KATHIERINE 1 )EPT OF STATISTICS )1R

  12. Target Location and ID From a Passive Multistatic Sensor Network Using Time Differences of Arrival (TDOAs) and the Hough Transform

    Science.gov (United States)

    2008-11-01

    UNIVERSITY PO BOX 97140 WACO TX 76798 DR JAMES STAPLETON 1 DEPT OF STATISTICS AND PROBABILITY MICHIGAN STATE UNIVERSITY EAST LANSING MI 48824 DR ENSOR ...UNIVERSITY 157 SCIENCE AND TECHNOLOGY II BUILDING FAIRFAX VA 22030 DR JAMES GENTLE 1 DEPT OF APPLIED ENGINEERING AND STATISTICS GEORGE MASON UNIVERSITY MS...STATE UNIVERSITY RALEIGH NC 27695-8203 DR JAMES D LYNCH 1 DEPT OF STATISTICS UNIVERSITY OF SOUTH CAROLINA COLUMBIA SC 29208 DR JAMES R SCHOTT 1 DEPT OF

  13. An Interpolation Procedure to Patch "Holes" in a Ground and Flight Test Data Base (MARS)

    Science.gov (United States)

    2010-08-01

    76798 DR JAMES STAPLETON 1 DEPT OF STATISTICS AND PROBABILITY MICHIGAN STATE UNIVERSITY EAST LANSING MI 48824 DR ENSOR KATHERINE 1 DEPT OF STATISTICS...TECHNOLOGY II BUILDING FAIRFAX VA 22030 DR JAMES GENTLE 1 DEPT OF APPLIED ENGINEERING AND STATISTICS GEORGE MASON UNIVERSITY MS 4A7 4400 UNIVERSITY DRIVE...27695-8203 DR JAMES D LYNCH 1 DEPT OF STATISTICS UNIVERSITY OF SOUTH CAROLINA COLUMBIA SC 29208 DR JAMES R SCHOTT 1 DEPT OF STATISTICS UNIVERSITY OF

  14. The powerless starchitect: How Zaha Hadid became the first person working on the Al-Wakrah stadium that actually did die

    OpenAIRE

    2016-01-01

    Starchitect Zaha Hadid won the bid to design one of the planned stadiums for the 2022 FIFA World Cup event in Qatar. Her design for the Al-Wakrah stadium became the centrepiece of a discussion on the role that starchitects play in society. That debate reached a boiling point in August 2014, and resulted in a digital lynching party that sheds serious doubts on the ethics and professionalism of architectural critics and journalists alike.

  15. Water Temperature and Concentration Measurements Within the Expanding Blast Wave of a High Explosive

    Science.gov (United States)

    2011-03-15

    housing was made of 1018 steel , and the gauge roof was extended to shield the opto- mechanical components from the primary blast wave. The input fiber...regions of each image indicate the steel frame and support crossbars of the gauge. This set of images provides a sense of the speed with which the shock was...University Press) [3] Peuker J M, Lynch P, Krier H and Glumac N 2009 Optical depth measurements of fireballs from aluminized high explosives Opt

  16. Genome-Wide Mapping of Furfural Tolerance Genes in Escherichia coli

    OpenAIRE

    Glebes, Tirzah Y.; Sandoval, Nicholas R.; Philippa J Reeder; Schilling, Katherine D.; Min ZHANG; Ryan T Gill

    2014-01-01

    Advances in genomics have improved the ability to map complex genotype-to-phenotype relationships, like those required for engineering chemical tolerance. Here, we have applied the multiSCale Analysis of Library Enrichments (SCALEs; Lynch et al. (2007) Nat. Method.) approach to map, in parallel, the effect of increased dosage for >105 different fragments of the Escherichia coli genome onto furfural tolerance (furfural is a key toxin of lignocellulosic hydrolysate). Only 268 of >4,000 E. coli ...

  17. Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

    DEFF Research Database (Denmark)

    Burn, John; Gerdes, Anne-Marie; Macrae, Finlay

    2011-01-01

    Observational studies report reduced colorectal cancer in regular aspirin consumers. Randomised controlled trials have shown reduced risk of adenomas but none have employed prevention of colorectal cancer as a primary endpoint. The CAPP2 trial aimed to investigate the antineoplastic effects of as...... of aspirin and a resistant starch in carriers of Lynch syndrome, the major form of hereditary colorectal cancer; we now report long-term follow-up of participants randomly assigned to aspirin or placebo....

  18. Revolution in Egypt and the Potential for a New Suez Crisis

    Science.gov (United States)

    2012-12-06

    the junta secured the appointment of a figurehead leader, General Muhammad Nagib, as prime minister and then forced King Farouk to abdicate the throne ... Game " In Revolution in the Arab World: Tunisia, Egypt, and the Unmaking of an Era, by Foreign Policy, ed. Marc Lynch, B Glasser Susan and Blake...Syracuse: Syracuse University Press, 1991. Bouckaert, Peter. "February 9: Egypt’s Foreigner Blame Game ." In Revolution in the Arab World: Tunisia

  19. Loglines. November-December 2012

    Science.gov (United States)

    2012-12-01

    courses such as “Understanding and Managing Conflict” and “ Myers - Briggs Type Indicator” are also beneficial, Lynch added. Newly selected supervisors...and that’s what career mapping is all about. It’s short, simple and gives you what you need to make good decisions .” With contracting, the largest...workforce and expand our expertise and knowledge through programs focused on education, leadership and professional development, diversity and career

  20. A New Tactic for Engagement with Iran: Faith-Based Diplomacy

    Science.gov (United States)

    2011-06-10

    accessed 1 May 2011). 46 Assembly of Experts and Expediency Council, an example of the nexus of wealth and power to influence within the Islamic...Charlotte Lynch, and Frederic Wehrey. Mullahs, Guards, and Bonyads: An Exploration of Iranian Leadership Dynamics. Santa Monica: RAND, 2010. Wehrey... Frederic , David E. Thaler, Nora Bensahel, Kim Cragin, Jerrold D. Green, Dalia Dassa Kaye, Nadia Oweidat, and Jennifer Li. Dangerous But Not Omnipotent

  1. Sanctioning Success? Assessing the Role of Sanctions in the Militarization of Iran

    Science.gov (United States)

    2010-12-01

    at the nexus of Middle Eastern and global relationships and intrigues. This approach to studying Iran, the role of sanctions in the militarization...political expansion in the 2000s is summarized in: David E. Thaler, Alireza Nader, Shahram Chubin, Jerrold D. Green, Charlotte Lynch, and Frederic ...of guarding the Revolution has translated into an informal role as the head of Iranian black market. 1. By Sea The nexus for much of the smuggling

  2. Why we do what we do: a theoretical evaluation of the integrated practice model for forensic nursing science.

    Science.gov (United States)

    Valentine, Julie L

    2014-01-01

    An evaluation of the Integrated Practice Model for Forensic Nursing Science () is presented utilizing methods outlined by . A brief review of nursing theory basics and evaluation methods by Meleis is provided to enhance understanding of the ensuing theoretical evaluation and critique. The Integrated Practice Model for Forensic Nursing Science, created by forensic nursing pioneer Virginia Lynch, captures the theories, assumptions, concepts, and propositions inherent in forensic nursing practice and science. The historical background of the theory is explored as Lynch's model launched the role development of forensic nursing practice as both a nursing and forensic science specialty. It is derived from a combination of nursing, sociological, and philosophical theories to reflect the grounding of forensic nursing in the nursing, legal, psychological, and scientific communities. As Lynch's model is the first inception of forensic nursing theory, it is representative of a conceptual framework although the title implies a practice theory. The clarity and consistency displayed in the theory's structural components of assumptions, concepts, and propositions are analyzed. The model is described and evaluated. A summary of the strengths and limitations of the model is compiled followed by application to practice, education, and research with suggestions for ongoing theory development.

  3. A protocol for genetic evaluation of patients with multiple colorectal adenomas and without evidence of APC gene mutation.

    Science.gov (United States)

    Rosner, Guy; Rozen, Paul; Bercovich, Dani; Shochat, Chen; Solar, Irit; Strul, Hana; Kariv, Revital; Halpern, Zamir

    2010-09-01

    Patients with multiple (Jewish individuals with 5 to > or = 40 colonic adenomas who did not fulfill Amsterdam (clinical) criteria for Lynch syndrome. Analyses included completion of APC gene exon 16 sequencing, analysis for APC gene copy number variations (deletions or duplications), MUTYH gene sequencing, and microsatellite instability in CRC patients fulfilling "Bethesda" (laboratory investigation) criteria for Lynch syndrome. Completion of APC gene exon 16 sequencing revealed one patient with the E1317Q polymorphism. All were normal by APC multiplex ligation-dependent probe amplification analysis. Pathogenic MUTYH mutations were found in three patients, all of North African origin; two additional patients had variants of unknown significance. One of six patients with Bethesda-positive criteria was MSI-High with immunohistology consistent with MLH1 mutation. Based on this small but well-characterized cohort with multiple colorectal adenomas, Lynch syndrome needs to be excluded if there are compatible criteria; otherwise MUTYH sequencing is probably the first step in evaluating APC-negative patients, especially for Jews of North African descent. Completing APC exon 16 sequencing and copy number variations analysis should probably be the last evaluations.

  4. The MLH1 c.1852_1853delinsGC (p.K618A variant in colorectal cancer: genetic association study in 18,723 individuals.

    Directory of Open Access Journals (Sweden)

    Anna Abulí

    Full Text Available Colorectal cancer is one of the most frequent neoplasms and an important cause of mortality in the developed world. Mendelian syndromes account for about 5% of the total burden of CRC, being Lynch syndrome and familial adenomatous polyposis the most common forms. Lynch syndrome tumors develop mainly as a consequence of defective DNA mismatch repair associated with germline mutations in MLH1, MSH2, MSH6 and PMS2. A significant proportion of variants identified by screening these genes correspond to missense or noncoding changes without a clear pathogenic consequence, and they are designated as "variants of uncertain significance", being the c.1852_1853delinsGC (p.K618A variant in the MLH1 gene a clear example. The implication of this variant as a low-penetrance risk variant for CRC was assessed in the present study by performing a case-control study within a large cohort from the COGENT consortium-COST Action BM1206 including 18,723 individuals (8,055 colorectal cancer cases and 10,668 controls and a case-only genotype-phenotype correlation with several clinical and pathological characteristics restricted to the Epicolon cohort. Our results showed no involvement of this variant as a low-penetrance variant for colorectal cancer genetic susceptibility and no association with any clinical and pathological characteristics including family history for this neoplasm or Lynch syndrome.

  5. Seafloor Mapping of the Southeast Iberian Continental Slope and Western Algero-Balearic Abyssal Plain

    Science.gov (United States)

    Lastras, G.; Canals, M.; León, C.; Elvira, E.; Pascual, L.; Muñoz, A.; de Cárdenas, E.; Acosta, J.

    2014-12-01

    We present the multibeam bathymetry and derived maps of the southeast Iberian margin from Cabo de Palos to Cabo de Gata, 37º35'N to 35º45'N and 2º10'W to 0º20'E, from the coastline down to the Algero-Balearic abyssal plain at depths exceeding 2,600 m. Data were obtained during different surveys in 2004, 2006 and 2007 on board R/V Vizconde de Eza with a Simrad EM300 multibeam echo-sounder, as part of the CAPESME Project, a collaboration between the Spanish Institute of Oceanography (IEO) and General Secretariat of Fisheries (SGP), aiming at creating maps of the fishing grounds of the Mediterranean continental margins of Spain. The edition of the maps has been carried out within the Complementary Action VALORPLAT (Scientific valorisation of multibeam bathymetry data from the Spanish continental shelf and slope), funded by the Spanish Ministry of Economy and Competitivity. Multibeam bathymetry data from the continental shelf obtained within the ESPACE project, also in a cooperative frame between IEO and SGP, completes the whole picture from the coastline to the deep abyssal plain. The map series is constituted by a general map at 1:400,000 scale and 14 detailed maps at 1:75,000 scale, which include inset maps on slope gradients and seafloor nature (rock or sediment type), the later obtained with rock dredges and Shipeck sediment dredges. Both the detailed maps and the general map are available in paper print, and the whole collection is also distributed in an edited USB. The geological features displayed in the different maps include the continental shelf, with abundant geomorphic features indicative of past sea-level changes, the continental slope carved by a large number of submarine canyons and gullies, including Palos, Tiñoso, Cartagena Este, Cartagena Oeste, Águilas, Almanzora, Alias, Garrucha and Gata submarine canyons, the Mazarrón, Palomares and Al-Mansour escarpments of probable tectonic origin, the Abubácer, Maimonides and Yusuf ridges, the

  6. Seafloor mapping of the southeast Iberian margin (from Cabo de Palos to Cabo de Gata)

    Science.gov (United States)

    Lastras, Galderic; Leon, César; Elvira, Elena; Pascual, Laura; Muñoz, Araceli; de Cárdenas, Enrique; Acosta, Juan; Canals, Miquel

    2014-05-01

    We present the multibeam bathymetry and derived maps of the southeast Iberian margin from Cabo de Palos to Cabo de Gata, 37º35'N to 35º45'N and 2º10'W to 0º20'E, from the coastline down to the Algero-Balearic abyssal plain at depths exceeding 2600 m. The edition of of the maps is carried out within the Complementary Action VALORPLAT ("Scientific valorisation of multibeam bathymetry data from the Spanish continental shelf and slope"), funded by the Spanish Ministry of Economy and Competitivity. The multibeam bathymetry data of the slope and abyssal plain were obtained during different surveys in 2004, 2006 and 2007 on board R/V Vizconde de Eza with a Simrad EM300 multibeam echo-sounder as part of the CAPESME Project, a collaboration between the Spanish Institute of Oceanography (IEO) and General Secretariat of Fisheries (SGP), primarily aiming at creating maps of the fishing grounds of the Mediterranean continental margins of Spain. Multibeam bathymetry data from the continental shelf were obtained within the ESPACE project, also in a cooperative frame between IEO and SGP. The map series is constituted by a general map at 1:400,000 scale and 14 detailed maps at 1:75,000 scale, which include inset maps on slope gradients and seafloor nature (rock or sediment type), the later obtained with rock dredges and Shipeck sediment dredges. Both the detailed maps and the general map are available in paper print, and the whole collection is also distributed in an edited USB. The geological features displayed in the different maps include the continental shelf, with abundant geomorphic features indicative of past sea-level changes, the continental slope carved by the Palos, Tiñoso, Cartagena Este, Cartagena Oeste, Águilas, Almanzora, Alias, Garrucha and Gata submarine canyons, the Mazarrón, Palomares and Al-Mansour escarpments, the Abubácer, Maimonides and Yusuf ridges, the Águilas and Al-Mansour seamounts, and the Algero-Balearic abyssal plain where prominent

  7. Spontaneous release of epiretinal membrane in a young weight-lifting athlete by presumed central rupture and centrifugal pull

    Directory of Open Access Journals (Sweden)

    Mansour AM

    2014-11-01

    Full Text Available Ahmad M Mansour,1,2 Hana A Mansour,3 J Fernando Arevalo4,5 1Department of Ophthalmology, Rafic Hariri University Hospital, Beirut, Lebanon; 2Department of Ophthalmology, American University of Beirut, Beirut, Lebanon; 3Department of Biology, American University of Beirut, Beirut, Lebanon; 4Retina Department, The King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia; 5Retina Department, Wilmer Eye Institute, The Johns Hopkins University, Baltimore, MD, USA Abstract: This patient presented for surgery at the age of 32 years, 14 months after his initial complaint of metamorphopsia and visual loss in the right eye. Past tests demonstrated a whitish epiretinal membrane (ERM with translucent stress lines over a thickened macula. Visual acuity was found on last presentation to be normal with minimal alteration on Amsler grid testing. A torn ERM was found in the center with left-over ERM temporally and rolled-over ERM nasally at the site of the epicenter with no posterior vitreous detachment. Visual recovery occurred gradually over several days 2 months prior to presentation apparently following heavy weight-lifting with a sensation of severe eye pressure. Sequential funduscopy and optical coherence tomography scans demonstrated the peeling of an ERM accompanied by normalization of foveal thickness. Valsalva maneuver had put excessive tension on ERM which tore in its center at the weakest line with gradual contraction of the ERM away from the fovea towards the peripapillary area. This is a new mechanism of self-separation of ERM induced by Valsalva. ERM in young subjects is subject to rupture and subsequent separation by tangential traction. There are three mechanisms for spontaneous separation of ERM: 1 posterior vitreous detachment with pulling of ERM by detaching vitreous (most common in adults; 2 the contracting forces of the immature ERM become stronger than its adhesions to the retina resulting in slow tangential traction on the

  8. Development of the so-called third stage laser Thomson scattering diagnostics of plasmas

    Science.gov (United States)

    Muraoka, Katsunori; Yamagata, Yukihiko; Hisano, Taishi; Uchino, Kiichirou; Miyazaki, Koichi

    2003-10-01

    In the recent review article,^1) we indicated that the incoherent laser Thomson scattering (LTS) diagnostics of plasmas for measurements of electron densities and temperatures (or more generally EEDFs) be classified as having evolved from the first stage where a whole Thomson spectrum be obtained during a single laser pulse from plasmas having electron density of above 10^18 m-3, through the second stage where data accumulation be prerequisite for ne below 10^18 m-3, and to the third stage where a strong suppression of stray light in addition to the data accumulation be necessary to measure at an extremely small size of less than 100 μm near to material surfaces. The third stage LTS was first demonstrated for a PDP (plasma display panel)-like discharge three years ago employing a triple grating polychromator. In order to further expand its applicable ranges, we are pursuing a more general approach by taking into account such factors as laser divergence, stray light suppression and other aspects. The present status is presented. 1) K. Muraoka, K. Uchino, Y. Yamagata, Y. Noguchi, M. Mansour, P. Suanpoot, S. Narishige, and M. Noguchi, Plasma Sources Sci. Technol. 11 (2002) A143.

  9. Mercury contamination in human hair and some marine species from Sfax coasts of Tunisia: levels and risk assessment.

    Science.gov (United States)

    Mezghani-Chaari, Sawssan; Hamza, A; Hamza-Chaffai, A

    2011-09-01

    The aim of this study was to measure the mercury (Hg) contents of three marine fish and common seafood species (Diplodus annularis, Sarpa salpa and Sepia officinalis) at two sampling sites in the gulf of Gabes, i.e. Sidi Mansour (polluted site) and Kerkennah (control site). These species are frequently consumed by the population living at the Sfax coasts of Tunisia, particularly by the families of fisherman. Additionally, the hair mercury levels of 55 volunteers (28 women, 27 men) were analysed and the daily total mercury intake through the fish and seafood diet was estimated. The key findings were: (1) the mercury contents of the examined fish and seafood species frequently exceeded the regulatory guideline value of 0.5 mg/kg, (2) no site-specific differences in hair mercury contents were found, (3) fish and seafood consumption is probably the major contributor of mercury exposure in this population, (4) the daily mercury intake through frequent consumption of D. annularis exceeds the US EPA reference dose. Further studies are necessary to evaluate the health risks associated with such high mercury exposure levels in order to allow optimal counseling and therapy of the concerned population and to avoid future impairment of human health, particularly children's health.

  10. Mitochondrial diaphorases as NAD+ donors to segments of the citric acid cycle that support substrate-level phosphorylation yielding ATP during respiratory inhibition

    Science.gov (United States)

    Kiss, Gergely; Konrad, Csaba; Pour-Ghaz, Issa; Mansour, Josef J.; Németh, Beáta; Starkov, Anatoly A.; Adam-Vizi, Vera; Chinopoulos, Christos

    2014-01-01

    Substrate-level phosphorylation mediated by succinyl-CoA ligase in the mitochondrial matrix produces high-energy phosphates in the absence of oxidative phosphorylation. Furthermore, when the electron transport chain is dysfunctional, provision of succinyl-CoA by the α-ketoglutarate dehydrogenase complex (KGDHC) is crucial for maintaining the function of succinyl-CoA ligase yielding ATP, preventing the adenine nucleotide translocase from reversing. We addressed the source of the NAD+ supply for KGDHC under anoxic conditions and inhibition of complex I. Using pharmacologic tools and specific substrates and by examining tissues from pigeon liver exhibiting no diaphorase activity, we showed that mitochondrial diaphorases in the mouse liver contribute up to 81% to the NAD+ pool during respiratory inhibition. Under these conditions, KGDHC's function, essential for the provision of succinyl-CoA to succinyl-CoA ligase, is supported by NAD+ derived from diaphorases. Through this process, diaphorases contribute to the maintenance of substrate-level phosphorylation during respiratory inhibition, which is manifested in the forward operation of adenine nucleotide translocase. Finally, we show that reoxidation of the reducible substrates for the diaphorases is mediated by complex III of the respiratory chain.—Kiss, G., Konrad, C., Pour-Ghaz, I., Mansour, J. J., Németh, B., Starkov, A. A., Adam-Vizi, V., Chinopoulos, C. Mitochondrial diaphorases as NAD+ donors to segments of the citric acid cycle that support substrate-level phosphorylation yielding ATP during respiratory inhibition. PMID:24391134

  11. Central cortical cleanup and zonular deficiency

    Directory of Open Access Journals (Sweden)

    Mansour AM

    2016-10-01

    Full Text Available Ahmad M Mansour,1,2 Rafic S Antonios,1 Iqbal Ike K Ahmed3 1Department of Ophthalmology, American University of Beirut, Beirut, Lebanon; 2Department of Ophthalmology, Rafic Hariri University Hospital, Beirut, Lebanon; 3Department of Ophthalmology, University of Toronto, Toronto, ON, Canada Background: Complete removal of the cortex has been advocated to prevent posterior capsular opacification but carries the risk of zonular dehiscence, hence there is a need for a safe maximal cortical cleanup technique in eyes with severe diffuse zonulopathy in subjects above age 90. Methods: We used bimanual central cortical cleaning by elevating central fibers and aspirating them toward the periphery. Peripheral cortical fibers were removed passively only when they became loose due to copious irrigation. A one-piece foldable implant was inserted without a capsular tension ring. Postoperative corticosteroid drops were used. Results: This technique was safely performed in a dozen eyes with severe pseudo-exfoliation or brunescent cataract with weak zonules. Posterior capsular rupture, iritis, vitreous loss, and lens subluxation were not observed. Moderate capsular phimosis occurred but with maintained central vision. Conclusion: The dogma of “complete cortical cleanup” in severe zonulopathy needs to be revisited in favor of a clear visual axis with maximal preservation of the damaged zonules. This technique is ideal in patients above age 90 where posterior capsular opacification and late dislocation of intraocular lens–capsule bag complex are unlikely to occur until several years postoperatively. Keywords: brunescent cataract, cortex aspiration, phacoemulsification, pseudo-exfoliation, weak zonules

  12. A Better Memoryless Online Algorithm for FIFO Buffering Packets with Two Values

    CERN Document Server

    Li, Fei

    2010-01-01

    We consider scheduling weighted packets in a capacity-bounded buffer. In this model, there is a buffer with a limited capacity B such that at any time, the buffer cannot accommodate more than B packets. Packets arrive over time. Each packet has a non-negative real value. Packets do not expire and they leave the buffer only because either we send them or we drop them. The packets that have left the buffer will not be reconsidered for delivery any more. In each time step, at most one packet in the buffer can be sent. The order in which the packets are sent should comply with the order of their arriving time. The objective is to maximize the total value of the packets sent in an online manner. In this paper, we study a variant of this model in which packets have value 1 or alpha > 1. We present a deterministic memoryless 1.305-competitive algorithm, improving the previously best known result 1.544 (Kesselman and Mansour. Journal of Algorithms 2003). In designing our algorithm, we apply a few new ideas. We do not...

  13. Penetrance of colorectal cancer among MLH1/MSH2 carriers participating in the colorectal cancer familial registry in Ontario

    Directory of Open Access Journals (Sweden)

    Choi Yun-Hee

    2009-08-01

    Full Text Available Abstract Background Several DNA mismatch repair (MMR genes, responsible for the majority of Lynch Syndrome cancers, have been identified, predominantly MLH1 and MSH2, but the risk associated with these mutations is still not well established. The aim of this study is to provide population-based estimates of the risks of colorectal cancer (CRC by gender and mutation type from the Ontario population. Methods We analyzed 32 families segregating MMR mutations selected from the Ontario Familial Colorectal Cancer Registry and including 199 first-degree and 421 second-degree relatives. The cumulative risks were estimated using a modified segregation-based approach, which allows correction for the ascertainment of the Lynch Syndrome families and permits account to be taken for missing genotype information. Results The risks of developing CRC by age 70 were 60% and 47% among men and women carriers of any MMR mutation, respectively. Among MLH1 mutation carriers, males had significantly higher risks than females at all ages (67% vs. 35% by age 70, p-value = 0.02, while the risks were similar in MSH2 carriers (about 54%. The relative risk associated with MLH1 was almost constant with age (hazard ratio (HR varied between 5.5-5.1 over age 30–70, while the HR for MSH2 decreased with age (from 13.1 at age 30 to 5.4 at age 70. Conclusion This study provides a unique population-based study of CRC risks among MSH2/MLH1 mutation carriers in a Canadian population and can help to better define and understand the patterns of risks among members of Lynch Syndrome families.

  14. Newly Identified Rydberg Emission Lines in Novae

    Science.gov (United States)

    Lynch, David K.; Rudy, R. J.; Bernstein, L. S.

    2008-09-01

    Newly Identified Rydberg Emission Lines in Novae David K. Lynch, Richard. J. Rudy (The Aerospace Corporation) & Lawrence S. Bernstein (Spectral Sciences, Inc.) Novae spectra in the near infrared frequently show a set of six emission lines that have not been positively identified (Williams, Longmore, & Geballe 1996, MNRAS, 279, 804; Lynch et al. 2001, AJ, 122, 2013; Rudy et al. 2002 ApJ, 573, 794; Lynch et al. 2004 Astron. J. 127, 1089-1097). These lines are at 0.8926, 1.1114, 1.1901, 1.5545, 2.0996 and 2.425 µm ± 0.005 µm. Krautter et al. (1984 A&A 137, 304) suggested that three of the lines were due to rydberg (hydrogenic) transitions in an unspecified atomic species that was in the 4th or 5th ionization stage (core charge = 4 & 5). We believe that Krautter et al.'s explanation is correct based on 4 additional lines that we have identified in the visible and near infrared spectrum of V723 Cassiopeiae. The observed Rydberg lines appear to originate from high angular momentum states with negligible quantum defects. The species cannot be determined with any certainty because in rydberg states, the outer electron sees a nucleus shielded by the inner electrons and together the inner atom appears to have a charge of +1, like hydrogen. As a result, the atom looks hydrogenic and species such as CV, NV, OV, MgV, SiV, etc. have their rydberg transitions at very similar wavelengths. All the lines represent permitted transitions, most likely formed by recombination. Atoms with core charges 4, 5 & 6 are rarely seen in the astrophysical environment because an extremely hot radiation field is necessary to ionize them. Thermonuclear runaways on the surface of a white dwarf can reach millions of degrees K, and thus there are enough X-ray photons available to achieve the necessary high ionization levels.

  15. ANATOMÍA PATOLÓGICA Y TUMORES HEREDITARIOS

    Directory of Open Access Journals (Sweden)

    Dra. M. Teresa Vial

    2017-07-01

    Nos referiremos desde el punto de vista patológico a algunas de las neoplasias malignas incluidas en síndromes de cáncer hereditario causados por los principales y más frecuentes genes de predisposición genética. Cáncer de Mama (BRCA1/2, Cáncer Colorectal no Polipósico/Síndrome de Lynch (MMR, Cáncer Gástrico Hereditario, Poliposis adenomatosa familiar (PAF, Cáncer Renal y Síndrome de von Hippel Lindau (VHL y Cáncer Medular de Tiroides (RET.

  16. Mimese do real e o real da mimese: a teatralidade obscena em Bernardo Carvalho

    Directory of Open Access Journals (Sweden)

    Olivier Allain

    2003-01-01

    Full Text Available This essay intends to investigate some of the textual strategies employed byBernardo Carvalho in severa! of his works bringing them a new understanding. The ques-tion unfolded is that of « theatrality » or rather that of the words landed from theatre thatwere, nevertheless, refunctionalized or questionned and that, in turn, interrogate the nar-rative they name. We found a strong consonnance with cinema as it is thought both ficcio-nnally and theoretically by authors such as David Lynch, Silviano Santiago, Guy Debordand Giorgio Agamben.

  17. Sebaceous adenomas in an MYH associated polyposis patient of Indian (Gujarati) origin.

    Science.gov (United States)

    Ajith Kumar, Vadakke Kanakath; Gold, June Anne; Mallon, Eleanor; Thomas, Shyamala; Hodgson, Shirley V

    2008-01-01

    MYH associated polyposis is an autosomal recessive polyposis syndrome with a high risk of large bowel cancer, caused by mutations in the DNA repair gene MYH. Founder mutations have been described in different ethnic groups. Muir Torre Syndrome is the association of internal malignancies with sebaceous gland tumours; Lynch Syndrome/Hereditary Non Polyposis Cancer is the best known cause. There has been a previous report of sebaceous gland tumours in an Italian patient with MYH associated polyposis. We describe a man of Indian (Gujarati) descent who has MYH associated polyposis and multiple sebaceous adenomas of the skin.

  18. El jardín secreto. Muholland Drive

    OpenAIRE

    2006-01-01

    Taking the analysis of the film Mulholland Drive by David Lynch as a starting point, we address the construction of a sort of femininity which works as a fascinating image within the current “entertainment” Western culture. This image of femininity has been created especially by Hollywood’s film industry, it being a reflect of the widespread absorption in the illusion growing in a world lacking any “real” contain, resulting from the effect of the makeup and spotlights. Here is a woman absolut...

  19. One Critical Defect of the Research Method of Learning from the Transcripts of an Oral Communication Task

    Institute of Scientific and Technical Information of China (English)

    刘思

    2012-01-01

      This essay aims to point out the one of the demerits hiding in the study approach of article---Learning from the Transcripts of an Oral Communication Task by Tony Lynch. The reason to make criticism on the study approach in this article stems from the significance of it in the study of off-line feedback. Many other scholars have made their own contribution to this field based on Lynch’s study. So ensuring the validity and reliability of the findings in this study is quite necessary, and an effective way to accomplish it is by examining the study approach in it.

  20. Light-Shifts of an Integrated Filter-Cell Rubidium Atomic Clock

    Science.gov (United States)

    2015-05-25

    rubidium atomic clock and basic research, Phys. Today , 60(11), 33-39 (2007). 2. R. T. Dupuis, T. J. Lynch, and J. R. Vaccaro, Rubidium frequency...AEROSPACE REPORT NO. TOR-2015-02236 Light-Shifts of an Integrated Filter-Cell Rubidium Atomic Clock May 25, 2015 James C. Camparo...COVERED - 4. TITLE AND SUBTITLE Light-Shifts of an Integrated Filter-Cell Rubidium Atomic Clock 5a. CONTRACT NUMBER FA8802-14-C-0001 5b

  1. A case study, Bagnoli: a difficult transition

    Directory of Open Access Journals (Sweden)

    Maria Antonietta Selvaggio

    2015-01-01

    In this research work we intend to verify how a particular physical-spatial dimension has influenced the social relations and the same identities of the people and their “community”, how we can delineate the perception and the performance of a urban transformation largely failed, and which contribution the citizens of Bagnoli can give to the urban design through their own imaginary and meanings they ascribe to their environment (Lynch 1960. In this sense, the study aim at giving a contribution to the participative practice, that up to now is out of the transition dynamics.

  2. Dos novelas de culto en la pantalla : 'Dune' y 'El almuerzo desnudo', fracasos gloriosos

    OpenAIRE

    2015-01-01

    Texto anteriormente publicado como 'Cult Novels on the Screen: Dune and The Naked Lunch'. En Fernando Toda, Juan A. Prieto Pablos, María José Mora y Teresa López Soto (eds.), Actas del XXI Congreso Internacional de AEDEAN. Sevilla: Universidad de Sevilla, 1999. 141-146 La adaptación de las novelas de culto admiradas por un público entusiasta plantea problemas específicos. Aquí examino la adaptación realizada por David Lynch de la novela de culto 'Dune' de Frank Herbert, y la que hizo David...

  3. Hazard Mitigation Potential of Earth-Sheltered Residences

    Science.gov (United States)

    1983-11-01

    Carnes, S. A., E. D. Copenhaver , J. H. Reed, E. J. Soderstrom, J. H, Sorensen, E. Peele, and D. J. Bjornstad, Incentives and the Siting of "Radioactive...618). Ezra, A. A., "Technology Utilization: Incentives and Solar Energy," Science 187:41-78,. 1975. Fairhurst., C., "Going Under to Stay on Top...9-12, 1975. Frank L. Moreland, ed. Prepared for the National Science Foundation, NSF-RA-760006, pp.71-76. Lynch, The Image of the City, Cambridge

  4. Two Cases of Endometrial Cancer in Twin Sisters with Myotonic Dystrophy

    Directory of Open Access Journals (Sweden)

    Ezra Y. Koh

    2016-01-01

    Full Text Available We describe two cases of endometrial cancer (EC occurring in nulligravid twin sisters with myotonic dystrophy. Both tested negative for Lynch syndrome and both were treated with laparoscopic hysterectomy with bilateral salpingooophorectomy and adjuvant radiotherapy. Although EC tends to run in families, the diagnosis in itself is not considered sufficient cause for screening or prophylactic measures in close relatives. However, the presence of additional risk factors, such as nulligravidity and myotonic dystrophy in the underlying cases, may call for extra vigilance in first-degree family members.

  5. Science.gov (United States)

    2004-05-01

    Screen break: emergency care staff based at The Royal London Hospital are in the spotlight as they take part in a 10-week BBC series, Trauma. A&E senior sister Elaine Cole (second from left) said: 'The programmes gave us the opportunity to portray just how diverse and exciting emergency nursing can be as well as showing the clinical and teamwork skills that emergency nurses possess.' Here, she is joined (left to right) by A&E consultant doctor Gareth Davies, A&E senior sister Toni Lynch, and helicopter emergency medical service (HEMS) registrar Andy Ratchford.

  6. Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays

    DEFF Research Database (Denmark)

    Heinen, Christopher D; Juel Rasmussen, Lene

    2012-01-01

    provided an important experimental tool for studying the functional consequences of VUS. However, beyond this repair assay, a number of other experimental methods have been developed that allow us to test the effect of a VUS on discrete biochemical steps or other aspects of MMR function. Here, we describe......ABSTRACT: With the discovery that the hereditary cancer susceptibility disease Lynch syndrome (LS) is caused by deleterious germline mutations in the DNA mismatch repair (MMR) genes nearly 20 years ago, genetic testing can now be used to diagnose this disorder in patients. A definitive diagnosis...

  7. China: Global Crisis Avoided, Robust Economic Growth Sustained (Ⅱ)

    Institute of Scientific and Technical Information of China (English)

    Gallina Andronova Vincelette; Alvaro Manoel; Ardo Hansson; Louis Kuijs

    2010-01-01

    @@ Ⅲ. Global crisis: impact and policy response The financial crisis that originated in the developed world intensified in September 2008 in the United States and began to spread globally. Since Lehman Brothers' bankruptcy,many other systemically relevant financial institutions (such as Freddie Mac, Fannie Mae, AIG, Merrill Lynch, and CitiGroup) have faced serious financing difficulties. In spreading beyond the United States and beyond the financial sector into the international money and capital markets, the previously heavy capital inflows to emerging market economies quickly and abruptly reversed. These developments did not leave China unaffected.

  8. Cancer Research Repository for Individuals With Cancer Diagnosis, High Risk Individuals, and Individuals With No History of Cancer (Control)

    Science.gov (United States)

    2016-11-14

    Pancreatic Cancer; Thyroid Cancer; Lung Cancer; Esophageal Cancer; Thymus Cancer; Colon Cancer; Rectal Cancer; GIST; Anal Cancer; Bile Duct Cancer; Duodenal Cancer; Gallbladder Cancer; Gastric Cancer; Liver Cancer; Small Intestine Cancer; Peritoneal Surface Malignancies; Familial Adenomatous Polyposis; Lynch Syndrome; Bladder Cancer; Kidney Cancer; Penile Cancer; Prostate Cancer; Testicular Cancer; Ureter Cancer; Urethral Cancer; Hypopharyngeal Cancer; Laryngeal Cancer; Lip Cancer; Oral Cavity Cancer; Nasopharyngeal Cancer; Oropharyngeal Cancer; Paranasal Sinus Cancer; Nasal Cavity Cancer; Salivary Gland Cancer; Skin Cancer; CNS Tumor; CNS Cancer; Mesothelioma; Breastcancer; Leukemia; Melanoma; Sarcoma; Unknown Primary Tumor; Multiple Myeloma; Ovarian Cancer; Endometrial Cancer; Vaginal Cancer

  9. Electron Excitation of Vibrational States of D2 and H2 and Detection of Excited States by Laser-Induced Fluorescence.

    Science.gov (United States)

    1984-04-01

    Fr other sets of excitation cross sections for H2 , see: M. G. Hi-ips and A. E. S. Green, J. Apdl. Phys. 46, 4718 (1975); P. Micheal and R. Winkler...Phys. 58, 4599 (1973); K. P. Lynch, T. C. Schwab, and J. V. Micheal , Int. J. Chem. Kinetics 8, 651 (1976). 51 i% %.€. - . . . ..-.-. ..-.-. " . .V...G. Ferguson and A. W. Read, Trans. Faraday Soc. 61 1559 (1965). 52 % *.~ *-.~:. -7_ 7o . .. ... ... .. .. .4 49. J. E. Land, J. Appl. Phys. 49, 5716

  10. Synthesis and Characterization of YB4 Ceramics

    Science.gov (United States)

    2011-06-24

    Sci., 39 [19] 5887 904 (2004). 2W. G. Fahrenholtz, G. E. Hilmas, I. G. Talmy, and J. A. Zaykoski, “Refractory Diborides of Zirconium and Hafnium ,” J...the Electronic Properties of YB4 and YB6 using 11B NMR and First-Principles Calculations,” J. Alloys Compd., 383 [1 2] 232 8 (2004). 8J. Günster, T...Compounds and Alloys ,” Akademia Nauk Ukrainskoi SSR, Kiev, 422 511 (1960) (in Russian) 15 J. F. Lynch, Engineering Properties of Selected Ceramic Materials

  11. [Bladder cancer at an early age in father and son].

    Science.gov (United States)

    Ovsiannikov, D; Stöhr, R; Hartmann, A; Böttrich, R; Hengstler, J G; Golka, K

    2011-12-01

    Bladder cancer may be caused by external factors like tobacco smoking, but may also be familial. We report on a father and son who developed this tumour at the ages of 45 and 35. Testing various genetic markers including the mismatch repair proteins MLH1, MSH2 and MSH6, whose loss is associated with a higher risk for hereditary non-polyposis colorectal cancer (HNPCC, Lynch syndrome), did not point to a familial disease. Thus the heavy smoking habits of the two patients must be considered as causal.

  12. Immunotherapy and patients treated for cancer with microsatellite instability.

    Science.gov (United States)

    Colle, Raphaël; Cohen, Romain; Cochereau, Delphine; Duval, Alex; Lascols, Olivier; Lopez-Trabada, Daniel; Afchain, Pauline; Trouilloud, Isabelle; Parc, Yann; Lefevre, Jérémie H; Fléjou, Jean-François; Svrcek, Magali; André, Thierry

    2017-01-01

    Microsatellite instability (MSI) is a tumor phenotype linked to somatic or germline (Lynch syndrome) inactivating alterations of DNA mismatch repair genes. A broad spectrum of neoplasms exhibits MSI phenotype, mainly colorectal cancer, endometrial cancer, and gastric cancer. MSI tumors are characterized by dense immune infiltration and high load of tumor neo-antigens. Growing evidence is accumulating on the efficacy of immune checkpoint inhibition for patients treated for MSI solid tumors. We present a comprehensive overview of MSI phenotype, its biological landscape and current diagnostic methods. Then we focus on MSI as a predictive biomarker of response to immune checkpoint inhibition in the context of colorectal cancer and non-colorectal tumors.

  13. PSA-Based Screening Outcomes, Dietary Heterocyclic Amine Exposure, and Prostate Cancer Risk in African Americans

    Science.gov (United States)

    2008-06-01

    vegetables, vitamin D, UV from sunlight, lycopene, and body size (Giovannucci et al., 1997, 1998; Cohen et al., 2000; Chan and Giovannucci, 2001a-b...micronutrients, and risk of prostate cancer. Epidemiol. Rev. 2001a: 23: 82-86. Chan J., and Giovannucci E. Dairy products, calcium, and vitamin D, and risk of...Mutat. Res. 1999: 443: 149-156. Keating G.A., Sinha, R., Layton, D., Salmon , C.P., Knize, M.G., Bogen, K.T., Lynch, C.F., and Alavanja, M. Comparison

  14. 论民族意象要素在少数民族村寨旅游开发中的保护%Protection of National Image Elements in Developing the Tourism of Minority Villages

    Institute of Scientific and Technical Information of China (English)

    林轶

    2008-01-01

    在1995年国家旅游局推出"民俗风情游"之后,少数民族村寨成为了旅游者向往的旅游目的地,但许多的少数民族村寨在进行旅游开发的过程中却存在着许多问题,凯文·林奇(Kevin Lynch)的城市意象理论将为少数民族村寨的旅游开发提供一个新的思路.

  15. Does Measurement Influence Behavior

    DEFF Research Database (Denmark)

    Schmidt, Marcus

    2014-01-01

    not access in their memory or that they otherwise would not form. Second, higher relative accessibility of intentions, compared with other inputs for purchase decisions may make subsequent purchase behavior more consistent with prior intentions. A couple of studies provide support of the self......The self-generated validity theory (Feldman and Lynch 1988) uses the following arguments: First, re-existing intentions may become more accessible in memory when the researcher asks the question. The measurement process thereby leads survey respondents to form judgments that they otherwise would...

  16. From Strategic Communication to Simply Communicate: Redefining SC in Military Communication

    Science.gov (United States)

    2011-04-10

    with and learn about people, places, and events that shape the world. As we enter the seco~d decade of the 20 111-century, Marshall McLuhan’s "global...Levinso~1, Paul. Digftal McLuhan : A Guide to the Information Millennium. Routledge, 1999 . . 2 Gilmore, Cliff. "B;eaking Down Opaque Stovepipes: A...Paul. Digital McLuhan : A Guide to the Information Millennium. Routledge, 1999 . . Lynch, Mark. "Al-Qaeda’s Media Strategies," National Interest

  17. An Analysis and Comparative Study of Job Characteristics Levels and Job Redesign Potential within the Strategic Air Command Maintenance Officer and Navigator Career Fields.

    Science.gov (United States)

    1985-09-01

    Lynch, J. C. Penney Company, Qantas Airways , and Reader’s Digest (10:193). The Air Force’s first experience with job enrichment was in 1974; a program...D-RI60 683 AN ANALYSIS AND COMPARATIVE STUDY OF JOB 1/2 CHARACTERISTICS LEVELS AND JOB R..(U) AIR FORCE INST OF TECH NRIGHT-PATTERSON RFD ON SCHOOL...MICROCOPY RESOLUTION TEST CHART P&ATfONAL BjREAu OF SrANDARS-l9 6 3 -A 0 OO AIN ANALYSIS AND COMPARATIVE STUDY OF JOB CHARACTERISTICS LEVELS AND JOB RED

  18. Strategy in clinical practice for classification of unselected colorectal tumours based on mismatch repair deficiency

    DEFF Research Database (Denmark)

    Jensen, Lars Henrik; Lindebjerg, J; Byriel, L

    2007-01-01

    nonpolyposis colon cancer or Lynch syndrome), but most are epigenetic changes of sporadic origin. The aim of this study was to define a robust and inexpensive strategy for such classification in clinical practice. Method Tumours and blood samples from 262 successive patients with colorectal adenocarcinomas...... to be sporadic. Results Thirty-nine (14.9%) of the tumours showed MMR deficiency by IHC or by microsatellite analysis. Sporadic inactivation by methylation of MLH1 promoter was found in 35 patients whereby the BRAF activating V600E mutation, indicating sporadic origin, was found in 32 tumours. On the basis...

  19. Stagnant or growing: Can management sciences evolve beyond known business challenges?

    Directory of Open Access Journals (Sweden)

    Geoff Goldman

    2011-12-01

    Full Text Available As global markets embark on some serious introspection after the global crisis of 2008, many business decision makers are asking "How did this happen?" What has become clear, however, is that we are stumbling from one business crisis to another. First it was corporate scandals such as Enron, Parmalat and Fidentia. Then came the financial crisis and the dire straits of, inter alia, Merrill Lynch, RBS, and Lehmann Brothers. Luckily, perhaps, it is not known what and when the next crisis will be. What is certain is that it will come. This begs the question: does business ever learn from what has gone before?

  20. Sound Speed Structure of the Northeast Atlantic Ocean in Summer 1973 during the SQUARE DEAL Exercise

    Science.gov (United States)

    1980-03-01

    velocities MIW enters the exercise area from the have been used in lieu of measured south after emanating from the Mediter - values whenever possible in all...SOURCE:LYNCH SV/STD 17 OF MEDITE CRRANEANNTER E57#28’N, 1140W LEGEND A*DFPTH OFMDTRAEN NEMDAE2 AUG 1973 w WATER (MIW) SALINITY MAXIMUM T4 BOTTOM OF...which app o thi documet a kmust be met, it mrhritributed the hol tronhe spe ific pr appr vol of th r or, Lut ’ caustic Prop Project, NST Ion, Misstsi