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Sample records for lynch margaret crean

  1. Lynch Syndrome

    Science.gov (United States)

    ... colon cancer may include surgery, chemotherapy and radiation therapy. Cancer screening for people with Lynch syndrome If you ... et al. Milestones of Lynch syndrome: 1895-2015. Nature Reviews Cancer. http://www.nature.com/nrc/journal/vaop/ncurrent/ ...

  2. Margaret Sanger

    Institute of Scientific and Technical Information of China (English)

    吴伟华

    2005-01-01

    Many women today have the freedom to decide when they will have children, if they want them. Until aboutfifty years ago, women spent most of their adultlives having children,year after year. This changed because of efforts by activists like Margaret Sanger. She believed that a safe and sure method of preventing pregnancy was a necessary condition for women's freedom. She also believed birth control was necessary for human progress.

  3. David Lynch (Sammelrezension)

    OpenAIRE

    2002-01-01

    Ralfdieter Füller: Fiktion und Antifiktion. Die Filme David Lynchs und der Kulturprozeß im Amerika der 1980er und 90er Jahre.Stefan Höltgen: Spiegelbilder. Strategien der ästhetischen Verdoppelung in den Filmen von David Lynch

  4. The Marketing of Margaret.

    Science.gov (United States)

    Elebash, Camille

    The 1983 British general election saw greater use than ever before in that country of sophisticated marketing research and techniques in the promotion of a party (the Conservatives) and a personality (Margaret Thatcher). With the help of an outside advertising agency, the Conservative Central Office had more marketing expertise than ever before,…

  5. Diagnosing Lynch Syndrome

    LENUS (Irish Health Repository)

    Gleeson, J

    2016-11-01

    Lynch Syndrome, also known as Hereditary Non-Polyposis Colorectal Cancer (HNPCC), is a hereditary condition that increases an individual’s risk of developing a constellation of cancers. These most commonly arise in the colon, but also involve other solid organs such as the endometrium and ovaries in women, the stomach, brain and the skin. Ireland’s small population offers an opportunity to identify all those with Lynch Syndrome (LS) in the country, which would represent a powerful preventive opportunity to meaningfully impact on the incidence of cancer in Ireland.

  6. Lynch Syndrome revision.

    Directory of Open Access Journals (Sweden)

    Sila Castellón Mortera

    2013-07-01

    Full Text Available The literature regarding colon`s adenocarcinoma hereditary no poliposico or Lynch Syndrome is reviewed. The clinical characteristics, genetics and histologycal of colon´s adenocarcinoma hereditary, no poliposico are pointed out, so as the updated criteria approved in Amsterdam, for the diagnostic of patients with this Syndrome. The therapeutics is updated.

  7. Lire Margaret Atwood

    OpenAIRE

    2016-01-01

    Ce recueil bilingue consacré à l'écrivain canadien Margaret Atwood, reconnue comme l'une des figures dominantes de la littérature d'expression anglaise, contient l'intervention qu'elle a prononcée à Rennes en novembre 1998 sur son roman The Handmaid's Tale (La Servante écarlate) et sur le genre auquel il appartient. Le roman, inscrit aux programmes 1999 du CAPES et de l'agrégation d'anglais, a été l'un des plus grands succès littéraires des années 80 aux États-Unis, au Canada et en Grande-Bre...

  8. Unusual presentation of Lynch Syndrome

    Directory of Open Access Journals (Sweden)

    Yu Veronica PCC

    2009-06-01

    Full Text Available Abstract Lynch Syndrome/HNPCC is a syndrome of cancer predisposition linked to inherited mutations of genes participating in post-replicative DNA mismatch repair (MMR. The spectrum of cancer associated with Lynch Syndrome includes tumours of the colorectum, endometrium, ovary, upper gastrointestinal tract and the urothelium although other cancers are rarely described. We describe a family of Lynch Syndrome with an hMLH1 mutation, that harbours an unusual tumour spectrum and its diagnostic and management challenges.

  9. Lynch syndrome-associated neoplasms

    DEFF Research Database (Denmark)

    Shia, Jinru; Holck, Susanne; Depetris, Giovanni;

    2013-01-01

    of interacting developments from the disciplines of clinical oncology, pathology, and molecular genetics, with each development serving to guide or enhance the next. The advancement of our understanding about the pathology of Lynch syndrome associated tumors exemplifies such intimate interplay among disciplines....... Today, accumulative knowledge has enabled surgical pathologists to detect tumors that are likely to be associated with Lynch syndrome, and the pathologist is playing an increasingly more important role in the care of these patients. The pathologist's ability is afforded primarily by information gained...... of such information. This article provides an overview of the development of histopathology and immunohistochemistry in Lynch syndrome-associated tumors, particularly in colorectal and endometrial cancers, and outlines the issues and current status of these specific pathologic aspects in not only the major tumors...

  10. Do Surrealismo em David Lynch

    Directory of Open Access Journals (Sweden)

    Mirian Tavares

    2009-01-01

    Full Text Available O surrealismo, como a arte do seu tempo, propõe uma nova estética, capaz de extrair o belo do absurdo e de instaurar o desvio para que daí surja, de fato, o real. Através da análise de algumas obras de David Lynch e dos livros Les champs magnétiques de Breton e Philippe Soupault e Poisson soluble, de Breton, irei mostrar a pertinência da designação surrealista para a obra do cineasta norte-americano. Lynch, como os surrealistas, constrói uma operação dialética entre o racional/irracional. Ao mesmo tempo em que opera no campo artístico em direção à irracionalidade absoluta, Lynch não nega a sua inserção na sociedade. Acredito que o realizador, como os surrealistas, tenha conseguido encontrar um equilíbrio entre as duas formas de se estar no mundo, racional/irracional, jogando com suas antíteses. O prazer do jogo surrealista consiste em ir até as profundezas do inconsciente e retornar com matéria suficiente para fazer uma obra de arte.Surrealism, as the art of its time, proposes a new aesthetics, one that is able to extract the beautiful from the absurd and to establish the swerve from the standard, from which, in fact, the real comes through. Through the analysis of some works by David Lynch, of Breton and Soupault's Les champs magnétiques, and of Breton's Poisson soluble, I will attempt to show the relevance of the surrealist designation for the work of the American filmmaker. Lynch, like the surrealists, builds a dialectic operation between the rational and the irrational. While operating in the artistic field towards absolute irrationality, Lynch does not deny its role in society. It is my belief that the director, as the surrealists, has managed to find a balance between the two ways of being in the world: rational and irrational; by playing with their antitheses. The pleasure of the surrealist game is to go to the depths of the unconscious and return with sufficient material to make a work of art out of it.

  11. Margaret Huggins and Tulse Hill Observatory

    Science.gov (United States)

    Becker, Barbara J.

    2016-04-01

    Photography, instrument design, methodology, interpretation - all skills brought to William Huggins' observatory by his persistent and careful wife Margaret. Together they developed spectroscopy into a powerful research tool. Barbara Becker tells the story.

  12. Enim ohustavad meie julgeolekut kliimamuutused / Margaret Beckett

    Index Scriptorium Estoniae

    Beckett, Margaret

    2007-01-01

    Kliimamuutustest tingitud loodusõnnetused õõnestavad kogu maailma julgeoleku alustalasid. Suurbritannia välisminister Margaret Beckett esines selle avaldusega ÜRO Julgeolekunõukogus New Yorgis 16. aprillil

  13. Enim ohustavad meie julgeolekut kliimamuutused / Margaret Beckett

    Index Scriptorium Estoniae

    Beckett, Margaret

    2007-01-01

    Kliimamuutustest tingitud loodusõnnetused õõnestavad kogu maailma julgeoleku alustalasid. Suurbritannia välisminister Margaret Beckett esines selle avaldusega ÜRO Julgeolekunõukogus New Yorgis 16. aprillil

  14. [Founder mutation in Lynch syndrome].

    Science.gov (United States)

    Cajal, Andrea R; Piñero, Tamara A; Verzura, Alicia; Santino, Juan Pablo; Solano, Angela R; Kalfayan, Pablo G; Ferro, Alejandra; Vaccaro, Carlos

    2016-01-01

    Lynch syndrome is the most frequent syndrome in hereditary colorectal cancer, a family-specific deleterious mutations in genes encoding DNA reparation proteins: MLH1 (mutL homolog 1), MSH2, MSH6 (mutS homolog 2 y 6, respectively), PMS2 (PMS1 homolog 2, mismatch repair system component) y MUTYH (mutY DNA glycosylase). The c.2252_2253delAA, p.Lys751Serfs*3 mutation in MLH1 gene segregates with a haplotype reported in the northern region of Italy and whose origin was attributed to a founder effect. This mutation co-segregates with typical characteristics of Lynch syndrome, including early age at onset and multiple primary tumors in the same individual, a high frequency of pancreatic cancer, high microsatellite instability and lack of PMS2 expression. This report describes a mutation in an Argentinian patient with endometrioid adenocarcinoma of uterus. Her first-degree relatives had a history of colon cancer diagnosed before 50 years, fulfilling the Amsterdam Criteria I and Lynch syndrome II. The high pathogenicity associated to this mutation makes necessary the study of all members from families with hereditary cancer, allowing pre-symptomatic genetic diagnosis, early assessment and the instauration of preventive treatments.

  15. Obituary Margaret Thatcher (1925-2013)

    Science.gov (United States)

    Koorts, W.

    2013-04-01

    In March this year, we celebrated the 40th anniversary of the official opening of SAAO Sutherland. On 8 April 2013 Margaret Thatcher passed away. You may wonder what is the connection between these two facts. Fewer and fewer people nowadays remember that Margaret Thatcher was present at the opening ceremony of the Sutherland Observatory on 15 March 1973, almost to the day, 40 years before her death.

  16. Modernization and Lynching in the New South

    Directory of Open Access Journals (Sweden)

    Mattias Smångs

    2016-09-01

    Full Text Available This article evaluates an emerging body of historical scholarship that challenges prevailing views of the primacy of rural conditions in southern lynching by positing that it was symbiotically associated with the processes of modernization underway in the region in the decades around 1900. Statistical analyses of lynching data that differentiate among events according to communal participation, support, and ceremony in Georgia and Louisiana from 1882 to 1930 and local-level indices of modernization (urbanization, rural depopulation, industrialization, agricultural commercialization, and dissolution of traditional family roles yield results that both support and contradict such a modernization thesis of lynching. The findings imply that the consequences of the social transformation in the South coinciding with the lynching era were not uniform throughout the region with regard to racial conflict and violence and that broad arguments proposing an intrinsic connection between modernization and lynchings therefore are overstated.

  17. Was Margaret Sanger a racist?

    Science.gov (United States)

    Valenza, C

    1985-01-01

    Margaret Sanger, as a young public health nurse, witnessed the sickness, disease and poverty caused by unwanted pregnancies. She spent the rest of her life trying to alleviate these conditions by bringing birth control to America. During the early 20th century, the idea of making contraceptives generally available was revolutionary. Contraceptive usage was considered a distinguishing feature of the 'haves.' In recent years, some revisionist biographers have portrayed Sanger as a eugenicist and a racist. This view has been widely publicized by critics of reproductive rights who have attempted to discredit Sanger's work by discrediting her personally. The basic concept of the eugenics movement in the 1920s and 1930s was that a better breed of humans would be created if the 'fit' had more children and the 'unfit' had fewer. This concept influenced a broad spectrum of thought, but there was little consensus on the definitions of fit and unfit. In theory, the movement was not racist--its message intended to cross race barriers for the overall advancement of mankind. Most eugenicists agreed that birth control would be a detriment to the human race and were opposed to it. Charges that Sanger's motives for promoting birth control were eugenic are not supported. In part of her most important work, "Pivot of Civilization," Sanger's dissent from eugenics was made clear. By examining extracts from her books, the author refutes the notion that Sanger was a eugenicist. Another unsupported argument raised by the anti-Sanger group was that Sanger, in her position as editor of "Birth Contol Review," published eugenicists' views. It would be more accurate to say that the review covered a wide range of opinions and research; the eugenicists views were included because they conferred respectability. David Kennedy, author of "Birth Control in America," does Sanger a grave injustice by falsely attributing to her the quotation: 'More children from the fit, less from the unfit--that is

  18. Lynch syndrome: still not a familiar picture

    Directory of Open Access Journals (Sweden)

    Hes Frederik J

    2008-02-01

    Full Text Available Abstract Background Germ line mutations in mismatch repair genes underlie Lynch syndrome and predispose carriers for colorectal carcinoma and malignancies in many other organ systems. Case presentation A large Lynch syndrome family with 15 affected family members and involvement in 7 organs is reported. It illustrates a lack of awareness and knowledge about this hereditary tumor syndrome among doctors as well as patients. None of the described family members underwent presymptomatic screening on the basis of the family history. Conclusion Hereditary features, like young age at diagnosis, multiple tumors in multiple organs and a positive family history, should lead to timely referral of suspected cases for genetic counseling and diagnostics. For Lynch syndrome, these features can be found in the Amsterdam and Bethesda criteria. Subsequently, early identification of mutation carriers might have diminished, at least in part, the high and early morbidity and mortality observed in this family.

  19. Bluebeards and bodies: Margaret Atwood’s men Bluebeards and bodies: Margaret Atwood’s men

    Directory of Open Access Journals (Sweden)

    Judith Still

    2008-04-01

    Full Text Available While most of the critical work on the Canadian writer Margaret Atwood focuses on her representation of women, this essays delves into the author’s portrayal of men and the masculine economy in “Alien Territory” and The Blind assassin. Enquanto a maioria dos críticos da escritora canadense Margaret Atwood concentram-se na representação das personagens femininas, este trabalho se aprofunda na caracterização dos homens e em uma economia masculina em “Alien Territory” e The Blind Assassin

  20. The Lynch syndrome: a management dilemma.

    Science.gov (United States)

    Palumbo, Piergaspare; Amatucci, Chiara; Perotti, Bruno; Dezzi, Claudia; Girolami, Marco; Illuminati, Giulio; Angelici, Alberto M

    2013-05-01

    The case of a familial Lynch syndrome is reported. The criteria for early diagnosis, management and surveillance are briefly reviewed. A germline mutation of genes responsible for mismatch repair is at the basis of the Lynch syndrome. Carriers are predisposed to colorectal cancer and other tumors. Two members of the presently reported family developed colorectal cancer, whereas two others developed other neoplasms. The syndrome was confirmed in members of the same family with appropriate genetic workup. Clinical examination and endoscopy were consequently scheduled once-a-year. Given the high risk of neoplastic disease, such yearly controls can be proposed as the standard follow-up of this condition.

  1. Role for Genetic Anticipation in Lynch Syndrome

    DEFF Research Database (Denmark)

    Nilbert, Mef; Timshel, Susanne; Bernstein, Inge

    2009-01-01

    PURPOSE: Anticipation (ie, an earlier age at onset in successive generations) is linked to repeat expansion in neurodegenerative syndromes, whereas its role in hereditary cancer is unclear. We assessed anticipation in Lynch syndrome (hereditary nonpolyposis colorectal cancer [HNPCC]), in which DN...

  2. Margaret Thatcher og afslutningen på Den Kolde Krig

    DEFF Research Database (Denmark)

    Sevaldsen, Jørgen

    2010-01-01

    Gennemgang af den britiske premierminister (1979-1990) Margaret Thatchers rolle i forbindelse med Murens fald i 1989. Med dansk perspektiv.......Gennemgang af den britiske premierminister (1979-1990) Margaret Thatchers rolle i forbindelse med Murens fald i 1989. Med dansk perspektiv....

  3. A Feminist Reading of Margaret Atwood's Surfacing

    Institute of Scientific and Technical Information of China (English)

    薛莹

    2008-01-01

    Margaret Atwood (1939-)is one of the most distinguished female writers in contemporary Canada.Surfacing is her second novel.published in 1972.Through the novel,Atwood expresses her deep concern about the women.Literally,it is about a iourney back to hometown and nature;but at the same time it also symbolizes a psychological journey for the heroine to find her true self.By analyzing the protagonist's personal experience with camera, ang abortion which serve as symbols of masculine power.this paper reveals women's dominated and victimized position in a male-oriented society,the gradual formation of the protagonist's feminist awareness and the process of her self-rediscovery.

  4. Merrill Lynch kavandab äridelegatsiooni visiiti Eestisse

    Index Scriptorium Estoniae

    2000-01-01

    Investeerimispanga Merrill Lynch eestvedamisel kavandatakse mais ärimeeste visiiti Eestisse, ütles Jüri Mõis, kes viibis New Yorgis toimunud Maailmapanga seminaril "Omavalitsused rahvusvahelistel kapitaliturgudel"

  5. Crean 'antimateria' en gran cantidad

    CERN Document Server

    Macedo, C

    2002-01-01

    "Como si se tratara de una historia de ciencia ficcion, un grupo de cientificos del Laboratorio Europeo de Fisica de Particulas (CERN), en Ginebra, anuncio que produjo por primera vez una gran cantidad de antimateria de hidrogeno, lo que representa un gran paso para entender la formacion del Universo" (1 page).

  6. Los guionistas hablan: cómo se crean personajes en la ficción nacional resultados de un estudio cualitativo

    Directory of Open Access Journals (Sweden)

    María Marcos Ramos

    2014-12-01

    Full Text Available Mediante un estudio de corte cualitativo en el que se realiza una entrevista a una muestra de guionistas en activo (n=19 se analiza el proceso de creación y de incorporación de personajes inmigrantes en las principales series y películas nacionales. Gracias al análisis de sus respuestas se pueden conocer los motivos por los cuales los personajes inmigrantes están infrarrepresentados y estereotipados, tal y como han indicado diversas investigaciones (Igartua; Barrios y Ortega, 2012; Marcos; Igartua; Frutos; Barrios; Ortega y Piñeiro, 2014. Del análisis de sus respuestas se puede saber cómo se crean los personajes inmigrantes en la ficción nacional, siendo este el objetivo de este estudio. Entre los resultados más significativos habría que destacar que los guionistas recurren a los estereotipos para crear personajes, especialmente cuando se habla de inmigrantes, además de que estos no son comerciales y su creación depende del género del programa. Sin embargo no ha habido unanimidad en otras cuestiones,como si hay actores inmigrantes, si desempeñan el rol de ignorante en las comedias y el uso de realidad en el proceso de creación.

  7. Mutation spectrum in South American Lynch syndrome families

    DEFF Research Database (Denmark)

    Dominguez-Valentin, Mev; Nilbert, Mef; Wernhoff, Patrik;

    2013-01-01

    Genetic counselling and testing for Lynch syndrome have recently been introduced in several South American countries, though yet not available in the public health care system.......Genetic counselling and testing for Lynch syndrome have recently been introduced in several South American countries, though yet not available in the public health care system....

  8. Recurrence and Variability of Germline EPCAM Deletions in Lynch Syndrome

    NARCIS (Netherlands)

    Kuiper, Roland P.; Vissers, Lisenka E. L. M.; Venkatachalam, Ramprasath; Bodmer, Danielle; Hoenselaar, Eveline; Goossens, Monique; Haufe, Aline; Kamping, Eveline; Niessen, Renee C.; Hogervorst, Frans B. L.; Gille, Johan J. P.; Redeker, Bert; Tops, Carli M. J.; van Gijn, Marielle E.; van den Ouweland, Ans M. W.; Rahner, Nils; Steinke, Verena; Kahl, Philip; Holinski-Feder, Elke; Morak, Monika; Kloor, Matthias; Stemmler, Susanne; Betz, Beate; Hutter, Pierre; Bunyan, David J.; Syngal, Sapna; Culver, Julie O.; Graham, Tracy; Chan, Tsun L.; Nagtegaal, Iris D.; van Krieken, J. Han J. M.; Schackert, Hans K.; Hoogerbrugge, Nicoline; van Kessel, Ad Geurts; Ligtenberg, Marjolijn J. L.

    2011-01-01

    Recently, we identified 3' end deletions in the EPCAM gene as a novel cause of Lynch syndrome. These truncating EPCAM deletions cause allele-specific epigenetic silencing of the neighboring DNA mismatch repair gene MSH2 in tissues expressing EPCAM. Here we screened a cohort of unexplained Lynch-like

  9. Management of extracolonic tumours in patients with Lynch syndrome

    NARCIS (Netherlands)

    Koornstra, Jan J; Mourits, Marian Je; Sijmons, Rolf H; Leliveld-Kors, Anna; Hollema, Harry; Kleibeuker, Jan H

    2009-01-01

    Hereditary nonpolyposis colorectal cancer, or Lynch syndrome, is responsible for 2-3% of all colorectal cancers. Lynch syndrome is also associated with a high risk of extracolonic cancers, including endometrial, stomach, small bowel, pancreas, biliary tract, ovary, urinary tract, brain, and skin can

  10. Margaret Cavendish and the Royal Society

    Science.gov (United States)

    Wilkins, Emma

    2014-01-01

    It is often claimed that Margaret Cavendish was an anti-experimentalist who was deeply hostile to the activities of the early Royal Society—particularly in relation to Robert Hooke's experiments with microscopes. Some scholars have argued that her views were odd or even childish, while others have claimed that they were shaped by her gender-based status as a scientific ‘outsider’. In this paper I examine Cavendish's views in contemporary context, arguing that her relationship with the Royal Society was more nuanced than previous accounts have suggested. This contextualized approach reveals two points: first, that Cavendish's views were not isolated or odd when compared with those of her contemporaries, and second, that the early Royal Society was less intellectually homogeneous than is sometimes thought. I also show that, although hostile to some aspects of experimentalism, Cavendish nevertheless shared many of the Royal Society's ambitions for natural philosophy, especially in relation to its usefulness and the importance of plain language as a means to disseminate new ideas. PMID:25254278

  11. Role for Genetic Anticipation in Lynch Syndrome

    DEFF Research Database (Denmark)

    Nilbert, Mef; Timshel, Susanne; Bernstein, Inge

    2009-01-01

    parent-child pairs in which age at the first cancer diagnosis was assessed. A paired t-test and a specifically developed bivariate model were used to assess a possible role of anticipation. RESULTS: Both methods revealed anticipation with children developing cancer mean 9.8 years (P ... parents using the paired t-test and 5.5 years (P ... to initiate surveillance programs at young age. It should also stimulate research into the genetic mechanisms that determine age at onset and whether the genetic instability that characterizes Lynch syndrome can be linked to anticipation....

  12. Glioblastomas, astrocytomas and oligodendrogliomas linked to Lynch syndrome

    DEFF Research Database (Denmark)

    Therkildsen, C; Ladelund, S; Rambech, E

    2015-01-01

    BACKGROUND AND PURPOSE: Brain tumors represent a rare and relatively uncharacterized tumor type in Lynch syndrome. METHODS: The national Danish Hereditary Nonpolyposis Colorectal Cancer Register was utilized to estimate the cumulative life-time risk for brain tumors in Lynch syndrome...... staining suggestive of the IDH1 R132H mutation. CONCLUSION: In Lynch syndrome brain tumors occurred in 14% of the families with significantly higher risks for individuals with MSH2 gene mutations and development of childhood brain tumors in individuals with constitutional MMR defects....

  13. The Identification of Lynch Syndrome in British Columbia

    Directory of Open Access Journals (Sweden)

    Carol M Cremin

    2009-01-01

    Full Text Available OBJECTIVE: To determine the prevalence of Lynch syndrome mutations in a Canadian hereditary cancer clinic population, and to determine the effectiveness of the program’s referral criteria and testing algorithm.

  14. Pupazzi di neve. David Lynch fotografo e l’"Unheimliche"

    Directory of Open Access Journals (Sweden)

    Paolo Sebastiano Lanzi

    2013-02-01

    Full Text Available L’opera di David Lynch non si limita al cinema, come ha dimostrato l’esposizione del 2007 alla Fondation Cartier di Parigi, The Air is on Fire. Tuttavia gli studi teorici hanno trascurato ciò che gallerie e musei hanno evidenziato da tempo: il Lynch pittore, fotografo, musicista, artista poliedrico. L’articolo si focalizza su una serie fotografica, Snowmen, ed è tratto da una ricerca di Paolo Sebastiano Lanzi sulla figura di David Lynch fotografo. Alla luce del saggio di Freud sul Perturbante (Das Unheimliche, 1919 si interpretano gli Snowmen come immagini di morte. Si chiariscono alcuni aspetti della poetica dell’artista-regista, come l’inquietudine dell’Inland Empire o di certe idee care al Surrealismo. Lo studio della produzione fotografica di Lynch riempie un vuoto nell’analisi critica sul suo lavoro, che va necessariamente riconsiderato in una prospettiva più ampia.

  15. The Impulse toward Comedy in Margaret Atwood's Poetry.

    Science.gov (United States)

    Benton, Carol L.

    The impulse toward comedy in the poetry of Canadian author Margaret Atwood occurs as a by-product of an interaction between scripted text and performing reader. Reading, then, may be profitably viewed as a rehearsal for both. In the classroom, this stylistic approach to Atwood's poetry can be emphasized over thematic analysis. In her poetry,…

  16. Margaret o. Afolabi, Abisola e. Ayilara, oluwafunmi A. Akinyemi and ...

    African Journals Online (AJOL)

    SurVeY of Drug uSe AMong Young PeoPle in ife, nigeriA. Margaret ... Obafemi Awolowo University, Ile-Ife, Nigeria, E-mail:bunmafol@yahoo.com; ... cially acceptable drugs like alcohol and ciga- ... cline in their academic performance, increase.

  17. A Polymath at Play: An Interview with Margaret Boden

    DEFF Research Database (Denmark)

    Prager, Phillip

    2014-01-01

    Margaret Boden is Research Professor of Cognitive Science at the University of Sussex, where she was the founding dean of the university’s School of Cognitive and Computing Sciences. Trained originally at the University of Cambridge and at Harvard University in medicine and the history of philoso...

  18. "Solid All the Way Through": Margaret Mahy's Ordinary Witches

    Science.gov (United States)

    Waller, Alison

    2004-01-01

    In "The Haunting," "The Changeover," and "The Tricksters," Margaret Mahy fuses supernatural iconography of witchcraft and magic with images of ordinary and domestic adolescence. This article argues that Mahy's "fantastic realism" illuminates aspects of female teenage experience through a blend of myth, fairy tale, folklore and history, as well as…

  19. Quality of colonoscopy in Lynch syndrome.

    Science.gov (United States)

    Niv, Yaron; Moeslein, Gabriela; Vasen, Hans F A; Karner-Hanusch, Judith; Lubinsky, Jan; Gasche, Christoph

    2014-12-01

    Lynch syndrome (LS) accounts for 2 - 4 % of all colorectal cancers. Affected family members have a germline mutation in one of the DNA mismatch repair genes MLH1, PMS2, MSH2, or MSH6, and a lifetime risk for development of colorectal cancer of 25 - 75 %. Current guidelines recommend annual to biannual surveillance colonoscopy in mutation carriers. Several factors may predict failure to prevent interval cancer in LS: more lesions in the right colon; more flat ("non polypoid") and lateral growing polyps; small adenomas may already harbor high grade dysplasia or a high percentage of villous component and become advanced adenomas; there is a short duration of the adenoma - carcinoma sequence; synchronous lesions have high prevalence; patients are younger and less tolerant to colonoscopy (need more sedation); and repeated colonoscopies are needed for lifelong surveillance (patient experience is important for compliance). In order to prevent cancer in LS patients, surveillance colonoscopy should be performed in an endoscopic unit experienced with LS, every 1 - 2 years, starting at age 20 - 25 years, or 10 years younger than the age of first diagnosis in the family (whichever is first), and yearly after the age of 40 years. Colonoscopy in LS patients should be a very meticulous and precise procedure (i. e. taking sufficient withdrawal time, documentation of such warranted), with removal of all of the polyps, special attention to the right colon and alertness to flat lesions. Following quality indicators such as successful cleansing of the colon and removal of every polyp will probably improve prevention of interval cancers. At this moment, none of the new endoscopic techniques have shown convincing superiority over conventional high resolution white light colonoscopy.

  20. Surveillance for urinary tract cancer in Lynch syndrome

    DEFF Research Database (Denmark)

    Bernstein, Inge Thomsen; Myrhøj, Torben

    2013-01-01

    Hereditary non-polyposis colorectal cancer (HNPCC) is an inherited multiorgan cancer syndrome, which when caused by a germline mutation in the mismatch repair (MMR) genes is known as Lynch syndrome (LS). Mutation carriers are at risk for developing cancers primarily in the colon, rectum and endom...

  1. Decrease in mortality in Lynch syndrome families because of surveillance.

    NARCIS (Netherlands)

    Jong, A.E. de; Hendriks, Y.M.; Kleibeuker, J.H.; Boer, S.Y. de; Cats, A.; Griffioen, G.; Nagengast, F.M.; Nelis, F.G.; Rookus, M.A.; Vasen, H.F.

    2006-01-01

    BACKGROUND & AIMS: Lynch syndrome family members have a high risk of developing colorectal (CRC), endometrial (EC), and other cancers. A large-scale surveillance program was introduced in The Netherlands in the late 1980s. The aims of the study were to evaluate the effectiveness of this program by a

  2. Role of new endoscopic techniques in Lynch syndrome

    NARCIS (Netherlands)

    Haanstra, Jasmijn F.; Kleibeuker, Jan H.; Koornstra, Jan J.

    2013-01-01

    Lynch syndrome, or hereditary nonpolyposis colorectal cancer (HNPCC), is the most common hereditary condition predisposing for colorectal cancer. International guidelines recommend surveillance of the colorectum by colonoscopy every 1-2 years starting at the age of 20-25 years. This has been shown t

  3. Sense of coherence and self-concept in Lynch syndrome

    DEFF Research Database (Denmark)

    Petersen, Helle Vendel; Ladelund, Steen; Carlsson, Christina

    2013-01-01

    Most individuals who learn about hereditary cancer manage well, but identification of subgroups who find this knowledge burdening would allow psychosocial intervention. The objective of the study was to assess sense of coherence (SOC) in individuals with Lynch syndrome with comparison to a genera...... population and correlation to self-concept....

  4. Genetic testing for Lynch syndrome: family communication and motivation

    NARCIS (Netherlands)

    C.H.M. Leenen (Celine); M.D. Heijer (Mariska den); C.A. van der Meer (Conny); E.J. Kuipers (Ernst); M.E. van Leerdam (Monique); A. Wagner (Anja)

    2016-01-01

    textabstractCurrent genetic counselling practice for Lynch syndrome (LS) relies on diagnosed index patients to inform their biological family about LS, referred to as the family-mediated approach. The objective of this study was to evaluate this approach and to identify factors influencing the uptak

  5. Risks of lynch syndrome cancers for msh6 mutation carriers

    NARCIS (Netherlands)

    L. Baglietto (Laura); N.M. Lindor (Noralane); J.G. Dowty (James); D.M. White (Darren); A. Wagner (Anja); E.B. Gómez García (Encarna); A.H.J.T. Vriends (Anette); N.R. Cartwright (Nicola); R.A. Barnetson (Rebecca); S.M. Farrington (Susan); A. Tenesa (Albert); H. Hampel (Heather); D. Buchanan (Daniel); S. Arnold (Sven); J. Young (Joanne); M.D. Walsh (Michael); J. Jass (Jeremy); F.A. Macrae (Finlay); Y. Antill (Yoland); I.M. Winship (Ingrid); G.G. Giles (Graham); J. Goldblatt (Jack); S. Parry (Susan); G. Suthers (Graeme); B. Leggett (Barbara); M. Butz (Malinda); M. Aronson (Melyssa); J.N. Poynter (Jenny); J.A. Baron (John); L. Le Marchand (Loic); R. Haile (Robert); S. Gallinger (Steve); J.L. Hopper (John); J. Potter (John); A. de La Chapelle (Albert); H. Vasen (Hans); M.G. Dunlop (Malcolm); S.N. Thibodeau (Stephen); M.A. Jenkins (Mark)

    2010-01-01

    textabstractBackground: Germline mutations in MSH6 account for 10%-20% of Lynch syndrome colorectal cancers caused by hereditary DNA mismatch repair gene mutations. Because there have been only a few studies of mutation carriers, their cancer risks are uncertain. Methods: We identified 113 families

  6. John Bowlby and Margaret s. Mahler: their lives and theories.

    Science.gov (United States)

    Coates, Susan W

    2004-01-01

    Traumatic aspects of the lives of John Bowlby and Margaret Mahler can be seen to inform their intellectual careers, a perspective that suggests that attachment theory and separation-individuation theory are far more consonant with one another than otherwise. Articulating the domains of convergence between the two theories reveals the essential complementarity of the special strengths of each. Both theories were attempts to understand the role of experience in the development of mental representations. Mahler paid close clinical attention to inner mental states and their evolution, while Bowlby searched for behavioral correlates that could lend themselves to empirical observation and inferences about internal representations.

  7. A Polymath at Play: An Interview with Margaret Boden

    DEFF Research Database (Denmark)

    Prager, Phillip

    2014-01-01

    Margaret Boden is Research Professor of Cognitive Science at the University of Sussex, where she was the founding dean of the university’s School of Cognitive and Computing Sciences. Trained originally at the University of Cambridge and at Harvard University in medicine and the history...... in Europe, North and South America, and Asia. Boden is known best for two widely translated books, The Creative Mind: Myths and Mechanisms, where she draws on computational ideas to explore human intuition, and the two-volume history of cognitive science, Mind as Machine: A History of Cognitive Science...

  8. MARGARET ATWOOD'S NON-FICTION ABOUT FICTION: PAYBACK

    Directory of Open Access Journals (Sweden)

    Igor Maver

    2015-10-01

    Full Text Available Margaret Atwood's provocative recent book of non-fiction contains many literary references, which help to effectively highlight her points about such a topical matter as debt, debt as a philosophical, politico-economic, religious, and historical issue over the centuries. In the central chapters of the book she looks at the Protestant Reformation and the introduction of interest on loans and in this light analyzes the novels by Dickens, Irving, Thackeray and G. Eliot. Her final statement in the book is, however, about the ecological debt we all have to pay to Earth in order to ensure our existence.

  9. Margaret Atwood: la sirena de géneros

    OpenAIRE

    Freire, Espido

    2009-01-01

    En la narrativa de Margaret Atwood la sorpresa, el uso poético del lenguaje y la reconstrucción constante de la identidad de los personajes guían al lector a traves de los distintos textos. Tanto en la reconstrucción de Los diarios de Susanna Moodie como en la traducción de emociones y sentimientos de la reina de Dinamarca en «La respuesta de Getrudis», la figura de las protagonistas femeninas fuertes e imprevisibles reinventan el misterio del eterno femenino. Las criadas y...

  10. Naiselik juhtimine mehelikus äris / Margaret Wheatley

    Index Scriptorium Estoniae

    Wheatley, Margaret

    2007-01-01

    Konsultant käsitleb naisjuhtide eeliseid, kummutab suurte liidrite otsimisega tekkinud müüdid, toob välja liidri olulised omadused. Lisad: Küsimus suurele ringile; Margaret Wheatley (CV). Vt. samas: Kahe karjääri perekond ehk kuidas tulevad töö- ja pereeluga toime Norra perekonnad; Scott Blanchard. Küsi iseendalt alustuseks kolm küsimust; Üllar Jaaksoo intervjuu: Riho ja Katrin Rasmann - Kas tüüpiline või ebatüüpiline kahe-karjääri-perekond?

  11. Naiselik juhtimine mehelikus äris / Margaret Wheatley

    Index Scriptorium Estoniae

    Wheatley, Margaret

    2007-01-01

    Konsultant käsitleb naisjuhtide eeliseid, kummutab suurte liidrite otsimisega tekkinud müüdid, toob välja liidri olulised omadused. Lisad: Küsimus suurele ringile; Margaret Wheatley (CV). Vt. samas: Kahe karjääri perekond ehk kuidas tulevad töö- ja pereeluga toime Norra perekonnad; Scott Blanchard. Küsi iseendalt alustuseks kolm küsimust; Üllar Jaaksoo intervjuu: Riho ja Katrin Rasmann - Kas tüüpiline või ebatüüpiline kahe-karjääri-perekond?

  12. The One-Sex Model in Margaret Cavendish‘s "Assaulted and Pursued Chastity"

    OpenAIRE

    Labisch, Martin

    2012-01-01

    Erörterung des One-Sex Models in Margaret Cavendishs "Assaulted and Pursued Chastity" und Einordnung dessen unter Betrachtung von Thomas Laqueurs One-Sex Theorie. The One-Sex Model in Margaret Cavendish‘s Assaulted and Pursued Chastity explained unter consideration of Thomas Laqueur's One-Sex theory.

  13. Review of Margaret Mahler: A biography of the psychoanalyst.

    Science.gov (United States)

    Bergner, Sharone

    2009-09-01

    Reviews the book, Margaret Mahler: A biography of the psychoanalyst by Alma Halbert Bond (see record 2008-07778-000). This psychobiography tells an evocative tale of the late Margaret Mahler's embattled, difficult, yet highly productive life. Mahler was a developmental researcher and a psychoanalyst. Her delineation of the separation-individuation process dramatically shifted psychoanalytic developmental theory, altering psychoanalytic understanding of pathogenesis and treatment. Her understanding of the mother-child matrix, as well as her approach to studying it, directly affected psychoanalytic child therapy as well, focusing clinical attention on the moment-by-moment vicissitudes of early development and also upon the possibility of altering its course through therapeutic intervention in the mother-child relationship. The book suffers from a number of problems: the narrative is sloppy, marred by numerous jarring, obvious, even surprising flaws. There is tremendous repetitiveness-sentences and whole passages are repeated verbatim within several pages. There are multiple errors, inconsistencies, and contradictions, including in the chapter notes and bibliography. Along with this shoddiness, there is reliance upon antiquated, sometimes simply inaccurate, conceptualizations and definitions of psychoanalytic and psychological ideas. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

  14. Lynch Syndrome Caused by Germline PMS2 Mutations

    DEFF Research Database (Denmark)

    Ten Broeke, Sanne W; Brohet, Richard M; Tops, Carli M

    2015-01-01

    . Standardized incidence ratios (SIRs) were calculated to estimate risks for other Lynch syndrome-associated cancers. RESULTS: The cumulative risk (CR) of CRC for male mutation carriers by age 70 years was 19%. The CR among female carriers was 11% for CRC and 12% for EC. The mean age of CRC development was 52......PURPOSE: The clinical consequences of PMS2 germline mutations are poorly understood compared with other Lynch-associated mismatch repair gene (MMR) mutations. The aim of this European cohort study was to define the cancer risk faced by PMS2 mutation carriers. METHODS: Data were collected from 98...... years, and there was a significant difference in mean age of CRC between the probands (mean, 47 years; range, 26 to 68 years) and other family members with a PMS2 mutation (mean, 58 years; range, 31 to 86 years; P

  15. Ssk or Esw? -- the Bloor-Lynch Debate Revisited

    Science.gov (United States)

    Cheng, Kai-Yuan

    2014-03-01

    Philosophical discussions of rule-following in the later Wittgenstein (1953, 1967) are an important source of inspiration for the development of views on the social nature of scientific knowledge. Two major opposing views in this inquiry -- Bloor's sociology of scientific knowledge (SSK) (1983, 1991, 1992, 1997) and Lynch's (1992, 1993) ethnomethodological studies of work (ESW) -- represent two positions derived from two different readings of Wittgenstein's later writings on rule-following. The aim of this paper is two-fold. One is to re-examine the noted Bloor-Lynch debate by considering Kusch's (2004) recent discussion of this debate. Another is to show that a new semantic framework of rule-following ascriptions based on a cognitive approach to the study of generics can be provided such that SSK and ESW are compatible in it (Leslie, 2009; Cheng, 2011).

  16. Surveillance colonoscopy practice in Lynch syndrome in the Netherlands: A nationwide survey

    Institute of Scientific and Technical Information of China (English)

    Jan J Koornstra; Hans FA Vasen

    2007-01-01

    Lynch syndrome, or hereditary nonpolyposis colorectal cancer (HNPCC), is the most common genetic disorder predisposing to colorectal cancer. As regular colonoscopic surveillance has been shown to reduce the incidence of colorectal cancer, this strategy is recommended worldwide. Recently, several advances in colonoscopic techniques have improved detection rates of neoplasia in Lynch syndrome. In this nationwide survey, we evaluated current surveillance colonoscopy practices for Lynch syndrome in the Netherlands and the extent to which advanced techniques have been adopted in routine clinical practice.

  17. Fertility and apparent genetic anticipation in Lynch syndrome.

    Science.gov (United States)

    Stupart, Douglas; Win, Aung Ko; Jenkins, Mark; Winship, Ingrid M; Goldberg, Paul; Ramesar, Rajkumar

    2014-09-01

    Genetic anticipation is the phenomenon in which age of onset of an inherited disorder decreases in successive generations. Inconsistent evidence suggests that this occurs in Lynch syndrome. A possible cause for apparent anticipation is fecundity bias, which occurs if the disease adversely affects fertility. The purpose of this study was to determine the effect of age of diagnosis of colorectal cancer (CRC) on lifetime fertility in Lynch syndrome, and whether this can falsely create the appearance of genetic anticipation. A computer model simulated age of diagnosis of CRC in hypothetical Lynch syndrome carriers and their offspring. The model assumed similar age distribution of CRC across generations (i.e. that there was no true anticipation). Age distribution of CRC diagnosis, and lifetime fertility rates (grouped by age of diagnosis of CRC) were determined from the Australasian Colorectal Cancer Family Registry (ACCFR). Apparent anticipation was calculated by comparing ages of diagnosis of CRC in affected parent-child pairs. A total of 1,088 patients with CRC were identified from the ACCFR. Total lifetime (cohort) fertility was related to age of diagnosis of CRC (correlation coefficient 0.13, P = 0.0001). In the simulation, apparent anticipation was 1.8 ± 0.54 years (P = 0.0044). Observed apparent anticipation in the ACCFR cohort was 4.8 ± 1.73 years (P = 0.0064). There was no difference in apparent anticipation between the simulate d and observed parent-child pairs (P = 0.89). The appearance of genetic anticipation in Lynch syndrome can be falsely created due to changes in fertility.

  18. The mutational spectrum of Lynch syndrome in cyprus.

    Science.gov (United States)

    Loizidou, Maria A; Neophytou, Ioanna; Papamichael, Demetris; Kountourakis, Panteleimon; Vassiliou, Vassilios; Marcou, Yiola; Kakouri, Eleni; Ioannidis, Georgios; Philippou, Chrystalla; Spanou, Elena; Tanteles, George A; Anastasiadou, Violetta; Hadjisavvas, Andreas; Kyriacou, Kyriacos

    2014-01-01

    Lynch syndrome is the most common form of hereditary colorectal cancer and is caused by germline mutations in the mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2. Mutation carriers have an increased lifetime risk of developing colorectal cancer as well as other extracolonic tumours. The aim of the current study was to evaluate the frequency and distribution of mutations in the MLH1, MSH2 and MSH6 genes within a cohort of Cypriot families that fulfilled the revised Bethesda guidelines. The study cohort included 77 patients who fulfilled at least one of the revised Bethesda guidelines. Mutational analysis revealed the presence of 4 pathogenic mutations, 3 in the MLH1 gene and 1 in the MSH2 gene, in 5 unrelated individuals. It is noted that out of the 4 pathogenic mutations detected, one is novel (c.1610delG in exon 14 of the MLH1) and has been detected for the first time in the Cypriot population. Overall, the pathogenic mutation detection rate in our patient cohort was 7%. This percentage is relatively low but could be explained by the fact that the sole criterion for genetic screening was compliance to the revised Bethesda guidelines. Larger numbers of Lynch syndrome families and screening of the two additional predisposition genes, PMS2 and EPCAM, are needed in order to decipher the full spectrum of mutations associated with Lynch syndrome predisposition in Cyprus.

  19. Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients

    Directory of Open Access Journals (Sweden)

    Kristen M. Drescher

    2010-01-01

    Full Text Available High levels of microsatellite instability (MSI-high are a cardinal feature of colorectal tumors from patients with Lynch Syndrome. Other key characteristics of Lynch Syndrome are that these patients experience fewer metastases and have enhanced survival when compared to patients diagnosed with microsatellite stable (MSS colorectal cancer. Many of the characteristics associated with Lynch Syndrome including enhanced survival are also observed in patients with sporadic MSI-high colorectal cancer. In this review we will present the current state of knowledge regarding the mechanisms that are utilized by the host to control colorectal cancer in Lynch Syndrome and why these same mechanisms fail in MSS colorectal cancers.

  20. The genetic basis of Lynch syndrome and its implications for clinical practice and risk management.

    Science.gov (United States)

    Cohen, Stephanie A; Leininger, Anna

    2014-01-01

    Lynch syndrome is the most common cause of hereditary colon cancer, and accounts for as much as 3% of all colon and endometrial cancers. The identification and management of individuals with Lynch syndrome have evolved over the past 20 years, yet the syndrome remains vastly underdiagnosed. It is important for clinicians to recognize individuals and families who are at risk in order to be able to manage them appropriately and reduce their morbidity and mortality from this condition. This review will touch on the history of Lynch syndrome, the current knowledge of genotype-phenotype correlations, the cancers associated with Lynch syndrome, and management of individuals who are gene carriers.

  1. Margaret Atwood: la sirena de géneros

    Directory of Open Access Journals (Sweden)

    Freire, Espido

    2009-06-01

    Full Text Available En la narrativa de Margaret Atwood la sorpresa, el uso poético del lenguaje y la reconstrucción constante de la identidad de los personajes guían al lector a traves de los distintos textos. Tanto en la reconstrucción de Los diarios de Susanna Moodie como en la traducción de emociones y sentimientos de la reina de Dinamarca en «La respuesta de Getrudis», la figura de las protagonistas femeninas fuertes e imprevisibles reinventan el misterio del eterno femenino. Las criadas y las señoras, desde sus peculiares puntos de vista, definen la sociedad con distancia y escepticismo, sabedoras de que son más de lo que el otro (el lector o los personajes pueden atisbar. En un acto lúdico constante, la literatura se convierte en un juego eterno, con las palabras como reglas.

  2. The Body of Hurt in Margaret Atwood's Novel Bodily Harm

    Directory of Open Access Journals (Sweden)

    Avital Gad Cykman

    2016-01-01

    This article analyses Margaret Atwood’s novel BODILY HARM (1981 in regard to its exploration of the link between corporeality and contextuality, focusing on the relation between the historical and socio-cultural context in which identity is constructed and the female character’s perception of body and self. The character’s retrospective journey serves as a ground for a deconstruction of the character’s values, behavior, relationships, and discomfort with the body in order to reveal the power relations and social causes behind her present situation. The study focuses on the literary articulation of the problems of being female, the exploration of the relation between the biological body and the cultural concept of the body, and the criticism of social representations of women.

  3. [Margaret Cavendish vs Robert Hooke: An impossible duel].

    Science.gov (United States)

    Aït-Touati, Frédérique

    2016-12-01

    In 1665, Robert Hooke published his major work in microscopy, Micrographia, a defense of experimental philosophy. The following year, Margaret Cavendish, Duchess of Newcastle, published at her own expense a treatise and a novel that undermined the basis of this new science. The dispute broke out at the initiative of the Duchess, in the context of a vast controversy about the legitimacy and the efficiency of optical instruments in natural philosophy. All the figures of the dual are used, except one: the counterattack. Cavendish, indeed, was alone on the battlefield. Is it possible to call a dual a battle with only one combatant? This particular case of dispute that stops owing to the shortage of combatants is the subject of this article.

  4. Distant Echo of a Strong Voice: Reflections on Margaret Mead's Evaluation of the Salzburg Seminar.

    Science.gov (United States)

    Patton, Michael Quinn

    2003-01-01

    Comments on the evaluation by Margaret Mead of the first Salzburg Seminar (1947). Notes the strength and clarity of Mead's evaluation report, which was written without the aid of the many tools on which today's evaluators draw. (SLD)

  5. Yetta Goodman, Maxine Greene, Louise Rosenblatt, and Margaret Meek Spencer: Language, Literacy, and Politics

    Science.gov (United States)

    Taylor, Denny

    2004-01-01

    Profiles of Yetta Goodman, Maxine Greene, Louise Rosenblatt, and Margaret Meek Spencer are given. They are the members of International Scholars' Forums in Literacy Studies at Hofstra, whose focus is language, literacy, politics and education.

  6. The Caring Business: Lynch Community Homes, Willow Grove, Pennsylvania. A Case Study.

    Science.gov (United States)

    Bogdan, Robert

    This paper, one of a series of reports describing innovative practices in integrating people with disabilities into community life, describes the Lynch Community Homes in Willow Grove, Pennsylvania. Lynch Homes is a for-profit organization that provides homes and supportive services for approximately 75 people with severe and profound…

  7. Advancing Scholarship and Intellectual Productivity: An Interview with Clifford A. Lynch

    Science.gov (United States)

    Hawkins, Brian L.

    2006-01-01

    In this second part of a two-part interview with Clifford A. Lynch, Executive Director of the Coalition for Networked Information, Lynch talks to Hawkins about the most provocative and exciting projects that are being developed in the field of networked information worldwide. He also talks on how institutional repositories are being currently…

  8. The genetic basis of Lynch syndrome and its implications for clinical practice and risk management

    Directory of Open Access Journals (Sweden)

    Cohen SA

    2014-07-01

    Full Text Available Stephanie A Cohen,1 Anna Leininger2 1Cancer Genetics Risk Assessment Program, St Vincent Health, Indianapolis, IN, USA; 2Minnesota Oncology, Woodbury, MN, USA Abstract: Lynch syndrome is the most common cause of hereditary colon cancer, and accounts for as much as 3% of all colon and endometrial cancers. The identification and management of individuals with Lynch syndrome have evolved over the past 20 years, yet the syndrome remains vastly underdiagnosed. It is important for clinicians to recognize individuals and families who are at risk in order to be able to manage them appropriately and reduce their morbidity and mortality from this condition. This review will touch on the history of Lynch syndrome, the current knowledge of genotype–phenotype correlations, the cancers associated with Lynch syndrome, and management of individuals who are gene carriers. Keywords: Lynch syndrome, hereditary cancer, hereditary nonpolyposis colorectal cancer, mismatch repair, mismatch repair genes, immunohistochemistry, microsatellite instability

  9. Verskunst in "finsteren Zeiten". Bertolt Brechts Sonette an Margarete Steffin // The Art of Verse in "Dark Times". Bertolt Brecht’s Sonnets for Margarete Steffin

    OpenAIRE

    Dane, Gesa

    2012-01-01

    Geschichte ist als Zeitgeschichte in den Sonetten an Margarete Steffin präsent. Eine Lektüre, die dieser Spur nachgeht, rückt diese Gedichte in die Nähe der Stücke Bertolt Brechts. Und dennoch bleiben sie als Liebesgedichte deutbar, in 'finisterer Zeit'. History as contemporary history is present in Brecht's sonnets written for Margarete Steffin. Following this thesis, the article shows the closeness of these poems to Brecht's plays. However, they can still be interpreted as love poems in...

  10. Margaret Cavendish's materialist critique of van Helmontian chymistry.

    Science.gov (United States)

    Clucas, Stephen

    2011-03-01

    A striking omission in the scholarship on the reception of the chymical philosophy of Jan Baptista van Helmont in England in the seventeenth century is the work of the mid-seventeenth-century natural philosopher Margaret Cavendish, Duchess of Newcastle. In her Philosophical Letters (1664), Cavendish offers an extended critique of Van Helmont's work (whose Ortus Medicince had recently been translated into English by John Sadler). In this paper, I compare Cavendish's criticisms with those of Robert Boyle in his Sceptical Chymist (1661). Both Boyle and Cavendish attacked Van Helmont for the obscurity of his chymical vocabulary and concepts, and attacked his seminalism. Although their critiques had much in common, they diverged in their attitudes to Van Helmont's experiments. As an opponent of the experimental philosophy, Cavendish had little interest in the quality of Van Helmont's experimental claims, whereas Boyle was critical of their unreplicability. I also try to show that the two writers had very different polemical agendas, with Boyle defending his vision of chymistry based on a corpuscularian natural philosophy, and Cavendish being as much concerned with establishing her religious orthodoxy as with defending the truth claims of her own materialist vitalism. For Cavendish, Van Helmont was an example of the dangers of mingling theology and natural philosophy.

  11. A four-fold humanity: Margaret Mead and psychological types.

    Science.gov (United States)

    Sullivan, Gerald

    2004-01-01

    Beginning in 1933, while working in New Guinea, Margaret Mead developed her so-called squares hypothesis. Mead never published its terms, though she made a brief comment on it in her autobiography, Blackberry Winter (1972), and the arguments found in Sex and Temperament in Three Primitive Societies (1935) and the research leading to Balinese Character (Bateson & Mead, 1942) bore its imprint. Beginning with William McDougall's distinction between temperament (innate predispositions) and character (learned organization of habit), Mead articulated a morphological approach to the interplay between biology and culture that yielded four primary and four intermediary personality types. Under specified but not inevitable circumstances, the conscious choices of a given people could render one or another of these types characteristic or predominantly stable within their population, giving each of the other types a definite relation to the dominant type and thereby the cultural ethos of its society. Persons of each type followed a developmental path specific to their type different both from that of other types and in its manifestations given the various relations of the individual's type to the dominant type. Mead's hypothesis was, therefore, a vision of the unity and diversity of a single human species as well as an approach to the differing psychological positioning of individuals in cultures. In examining Mead's hypothesis, this essay also takes up Mead's debts to several leading psychologists (McDougall, C. G. Jung, and Erik Erikson), and (provisionally) how her vision differed from that of Ruth Benedict.

  12. Novel Implications in Molecular Diagnosis of Lynch Syndrome

    Directory of Open Access Journals (Sweden)

    Raffaella Liccardo

    2017-01-01

    Full Text Available About 10% of total colorectal cancers are associated with known Mendelian inheritance, as Familial Adenomatous Polyposis (FAP and Lynch syndrome (LS. In these cancer types the clinical manifestations of disease are due to mutations in high-risk alleles, with a penetrance at least of 70%. The LS is associated with germline mutations in the DNA mismatch repair (MMR genes. However, the mutation detection analysis of these genes does not always provide informative results for genetic counseling of LS patients. Very often, the molecular analysis reveals the presence of variants of unknown significance (VUSs whose interpretation is not easy and requires the combination of different analytical strategies to get a proper assessment of their pathogenicity. In some cases, these VUSs may make a more substantial overall contribution to cancer risk than the well-assessed severe Mendelian variants. Moreover, it could also be possible that the simultaneous presence of these genetic variants in several MMR genes that behave as low risk alleles might contribute in a cooperative manner to increase the risk of hereditary cancer. In this paper, through a review of the recent literature, we have speculated a novel inheritance model in the Lynch syndrome; this could pave the way toward new diagnostic perspectives.

  13. “Silencio”: hearing loss in David Lynch's Mulholland Drive

    Directory of Open Access Journals (Sweden)

    Allister Mactaggart

    2014-11-01

    Full Text Available In a filmmaking career replete with extraordinary images and sounds, David Lynch's Mulholland Drive (2001 stands out for attention as a striking and seemingly inexhaustible resource for analysis. In this article, this film is used to examine the specific ways in which Lynch uses pre-existing pop songs to wrap the spectator within the filmic soundscape. Nowhere is the complexity and uncanniness of pop music made more explicit than in Rebekah Del Rio's stunning performance of “Llorando (Crying” in the Club Silencio scene. The split between the singer's powerful performance and her subsequent collapse with the sound of the voice left hanging in the air marks a pivotal point in the film. This scene, coupled with other examples of feminine jouissance, is contrasted with the deadening roar of the master's voice, which solely demands obedience but is deaf to any reply. At the core of this article is an analysis of the status of the voice (and the gaze as examples of the Lacanian object a and its relationship to Marx's concept of surplus value. Mulholland Drive provides a powerful demonstration of how these concepts can be seen, heard, and felt in relation to film, and how sound can reverberate into the spaces and silences beyond the screen.

  14. Prevalence of Lynch syndrome and Lynch-like syndrome among patients with colorectal cancer in a Japanese hospital-based population.

    Science.gov (United States)

    Chika, Noriyasu; Eguchi, Hidetaka; Kumamoto, Kensuke; Suzuki, Okihide; Ishibashi, Keiichiro; Tachikawa, Tetsuhiko; Akagi, Kiwamu; Tamaru, Jun-Ichi; Okazaki, Yasushi; Ishida, Hideyuki

    2017-02-09

    We investigated the prevalence of Lynch syndrome and Lynch-like syndrome among Japanese colorectal cancer patients, as there have been no credible data from Japan. Immunohistochemical analyses for mismatch repair proteins (MLH1, MSH2, MSH6 and PMS2) were carried out in surgically resected, formalin-fixed paraffin-embedded specimens obtained from 1,234 newly diagnosed colorectal cancer patients between March 2005 and April 2014. The presence/absence of the BRAF V600E mutation and hypermethylation of the MLH1 promoter was analyzed where necessary. Genetic testing was finally undertaken in patients suspected as having Lynch syndrome. By the universal screening approach with immunohistochemical analysis for mismatch repair proteins followed by analyses for the BRAF V600E mutation and MLH1 promoter methylation status, 11 (0.9%) of the 1,234 patients were identified as candidates for genetic testing. Out of the 11 patients, 9 (0.7%) were finally diagnosed as having Lynch syndrome; the responsible genes included MLH1 (n = 1), MSH2 (n = 4), EPCAM (n = 1) and MSH6 (n = 3). The remaining two patients (0.2%) were regarded as having Lynch-like syndrome, since biallelic somatic deletion of the relevant mismatch repair genes was detected in the absence of germline mismatch repair alterations. None of the cases was identified as having germline MLH1 epimutation. The prevalence of Lynch syndrome among all newly diagnosed cases of colorectal cancer in Japan is in the same range as that recently reported by studies in Western population. The prevalence of Lynch-like syndrome seems to be extremely low.

  15. Antigone e le altre. Figure mitiche al femminile nei saggi di Margarete Susman

    Directory of Open Access Journals (Sweden)

    Giuliano Lozzi

    2015-12-01

    Full Text Available In Margarete Susman’s theoretical and political essays and studies, classical and mythological figures such as Antigone, Pythia, Diotima and Undine become symbols for women’s situation as well as the broader cultural, political and social sphere. The connection between these mythological themes and the intimate, spiritual and intellectual evolution of the author herself signals the originality of her work in women’s studies in general, in women’s literature theory and in mythological studies. This article aims to illustrate the symbolic reading of female mythical figures in Margarete Susman’s writings, also focusing on the connection between mythos and the cultural importance of the maternal function. The icons of the feminine are also objects of Margarete Susman’s writing, addressing questions about the connection of religious attitudes and socio-cultural determined thought.

  16. Distinct gene expression profiles in ovarian cancer linked to Lynch syndrome

    DEFF Research Database (Denmark)

    Jönsson, Jenny-Maria; Bartuma, Katarina; Dominguez-Valentin, Mev

    2014-01-01

    Ovarian cancer linked to Lynch syndrome represents a rare subset that typically presents at young age as early-stage tumors with an overrepresentation of endometrioid and clear cell histologies. We investigated the molecular profiles of Lynch syndrome-associated and sporadic ovarian cancer...... ovarian cancers. Lynch syndrome-associated and sporadic ovarian cancers differed by 349 significantly deregulated genes, including PTPRH, BIRC3, SHH and TNFRSF6B. The genes involved were predominantly linked to cell growth, proliferation, and cell-to-cell signaling and interaction. When stratified...... for histologic subtype, hierarchical clustering confirmed distinct differences related to heredity in the endometrioid and serous subtypes. Furthermore, separate clustering was achieved in an independent, publically available data set. The distinct genetic signatures in Lynch syndrome-associated and sporadic...

  17. Media lynching in Romanian mass media and politics. Definition and short explanations

    OpenAIRE

    Ion Novăcescu

    2013-01-01

    The Monitoring Report of justice in Romania, published by the European Commission in late January of this year, has sparked an intense controversy in Romanian politics between the president of Romania and the prime minister of the country, which has focused on the mediatic lynching who was practiced against the judges and the anti-corruption prosecutors. This article defines and analyzes the mediatic lynching and its specific features that distinguish it from a press campaign.

  18. Media lynching in Romanian mass media and politics. Definition and short explanations

    Directory of Open Access Journals (Sweden)

    Ion Novăcescu

    2013-04-01

    Full Text Available The Monitoring Report of justice in Romania, published by the European Commission in late January of this year, has sparked an intense controversy in Romanian politics between the president of Romania and the prime minister of the country, which has focused on the mediatic lynching who was practiced against the judges and the anti-corruption prosecutors. This article defines and analyzes the mediatic lynching and its specific features that distinguish it from a press campaign.

  19. Risk of Cancer in Cases of Suspected Lynch Syndrome Without Germline Mutation

    OpenAIRE

    Rodríguez-Soler, María; Pérez-Carbonell, Lucía; Guarinos, Carla; Zapater, Pedro; Castillejo, Adela; Barberá, Víctor Manuel; Juárez, Miriam; Bessa, Xavier; Xicola, Rosa M; Clofent, Juan; Bujanda, Luis; Balaguer, Francesc; Reñé, Josep-Maria; de Castro, Luisa; Marín-Gabriel, José C.

    2013-01-01

    Background & Aims: Colorectal cancers (CRCs) with microsatellite instability (MSI) and a mismatch repair (MMR) immunohistochemical deficit without hypermethylation of the MLH1 promoter are likely to be caused by Lynch syndrome. Some patients with these cancers have not been found to have pathogenic germline mutations and are considered to have Lynch-like syndrome (LLS). The aim of this study was to determine the risk of cancer in families of patients with LLS. Methods: We studied a population...

  20. Distinct Gene Expression Signatures in Lynch Syndrome and Familial Colorectal Cancer Type X

    DEFF Research Database (Denmark)

    Valentin, Mev; Therkildsen, Christina; Veerla, Srinivas;

    2013-01-01

    Heredity is estimated to cause at least 20% of colorectal cancer. The hereditary nonpolyposis colorectal cancer subset is divided into Lynch syndrome and familial colorectal cancer type X (FCCTX) based on presence of mismatch repair (MMR) gene defects.......Heredity is estimated to cause at least 20% of colorectal cancer. The hereditary nonpolyposis colorectal cancer subset is divided into Lynch syndrome and familial colorectal cancer type X (FCCTX) based on presence of mismatch repair (MMR) gene defects....

  1. Papillary thyroid carcinoma (PTC) in Lynch syndrome: Report of two cases and discussion on Lynch syndrome behaviour and genetics.

    Science.gov (United States)

    Pelizzo, M R; Pennelli, G; Zane, M; Galuppini, F; Colletti, P M; Merante Boschin, I; Rubello, D

    2015-08-01

    We present here two cases of papillary thyroid carcinoma (PTC) in patients affected by Lynch syndrome (LS). The first case is a 47-year-old woman with typical hereditary non-polyposis colorectal cancer (HNPCC) syndrome, reported with endometrial and ovarian carcinoma at age 43, and colon cancer at age 45. The patient underwent total thyroidectomy and central node dissection in 2007, at 47years old, with a histological diagnosis of PTC (T1aN1a). Molecular genetics showed a germ-line mutation of the MLH1 gene, 1858 G>T(E620X), with substitution of glycine with a stop codon at position 620. This mutation has pathogenetic significance and was considered responsible for the various tumours of the HNPCC spectrum. In particular, in the same kindred, spanning 5 generations, there were 5 members with colorectal cancer, 4 with endometrial cancer, 3 with gastric and 2 with breast cancer. The second case is a 34-year-old man with typical HNPCC syndrome with colonic resection for colon cancer at age 21. The patient underwent total thyroidectomy with central and lateral node dissection in 2010, at age 34, with a histological diagnosis of PTC with nodal metastases (pT4N1b). Molecular genetic analysis showed a germ-line mutation of the MSH2 gene (thymine insertion at position 907). This mutation had pathogenetic significance and was considered responsible for HNPCC development. Two similar cases have been reported: a 39-year-old woman, and a 44-year-old woman, affected by HNPCC syndrome, with anaplastic thyroid carcinoma and undifferentiated thyroid carcinoma, respectively. We reviewed the Lynch syndrome literature on the history, genetics and expanding tumour spectrum of this condition. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  2. [Prime Ministers Eugenia Charles of Dominica, Margaret Thatcher and Indira Gandhi

    OpenAIRE

    Cooper, Neil

    2004-01-01

    207 x 153 mm. A photograph showing Eugenia Charles, Prime Minister of Dominica, Margaret Thatcher, British Prime Minister, and Indira Gandhi, Indian Prime Minister, with Tom Adams, Prime Minister of Barbados, and Lester Bird, Deputy Prime Minister and Foreign Minister of Antigua and Barbuda, behind them. The delegates are pictured at Fort Aguada, Goa.

  3. Psychology of Women and the Potential for Influencing Students' Lives: An Interview with Margaret W. Matlin.

    Science.gov (United States)

    Van Wallendael, Lori R.

    2001-01-01

    Presents an interview with Margaret Matlin, a teaching professor at the State University of New York (SUNY) Geneseo. Focuses on the courses Matlin taught when first at SUNY Geneseo, what she currently teaches, her psychology of women course, special techniques she uses, and whether she feels she is a natural born teacher. (CMK)

  4. "I Just Don't Understand It": Teaching Margaret Atwood's "Rape Fantasies."

    Science.gov (United States)

    Tyler, Lisa

    1998-01-01

    Discusses Margaret Atwood's "provocative and funny" short story "Rape Fantasies," and describes how, when teaching this story the author encourages students to sympathize with Estelle (the narrator) before they judge her (instead of rushing to achieve closure and begin interpretation). (SR)

  5. Women's Oppressed and Disfigured Life in Margaret Atwood's the Handmaid's Tale

    Science.gov (United States)

    Zarrinjooee, Bahman; Kalantarian, Shirin

    2017-01-01

    The present study attempts to analyze Margaret Atwood's (1939-) "The Handmaid's Tale" (1985) based on theories of feminist thinker, Simone de Beauvoir (1908-1986) and applies her theories presented in "The Second Sex" (1949) that leads to better apprehension of sex and gender. Beauvoir's ideology focuses mainly on the cultural…

  6. 'Vulgar publicity' and the problems of privacy in Margaret Oliphant's 'Salem Chapel'

    NARCIS (Netherlands)

    T. MacDonald

    2011-01-01

    This article examines Margaret Oliphant's Salem Chapel (1863), the author's only foray into the sensation genre. It argues that the novel's focus on the dangers of gossip and public exposure reveals Oliphant's fraught relationship with sensationalism. Two key characters represent sensational readers

  7. Pedagogy and Passages: The Performativity of Margaret Cavendish's Utopian Fiction

    Science.gov (United States)

    Gregoriou, Zelia

    2013-01-01

    This article explores the pedagogical significance of non-static and hybrid utopian readings and writings by focusing on Margaret Cavendish's educationally-philosophically neglected female utopia "The Description of a New World, Called the Blazing World." It questions the exaggerated, inflated and exclusivist emphasis on the…

  8. Genetic testing for Lynch syndrome: family communication and motivation.

    Science.gov (United States)

    Leenen, Celine H M; Heijer, Mariska den; van der Meer, Conny; Kuipers, Ernst J; van Leerdam, Monique E; Wagner, Anja

    2016-01-01

    Current genetic counselling practice for Lynch syndrome (LS) relies on diagnosed index patients to inform their biological family about LS, referred to as the family-mediated approach. The objective of this study was to evaluate this approach and to identify factors influencing the uptake of genetic testing for LS. In 59 mutation carriers, 70 non carriers and 16 non-tested relatives socio-demographic characteristics, family communication regarding LS, experiences and attitudes towards the family-mediated approach and motivations for genetic testing, were assessed. The majority of all respondents (73 %) were satisfied with the family-mediated approach. Nevertheless, 59 % of the respondents experienced informing a family member and 57 % being informed by a family member as burdensome. Non-tested differed from tested respondents, in that they were younger, less closely related to the index patient and a lower proportion had children. The most important reasons for declining genetic testing were (1) anticipating problems with life insurance and mortgage, (2) being content with life as it is, and (3) not experiencing any physical complaints. In conclusion, the majority of respondents consider the current family-mediated information procedure acceptable, although the provision of information on LS by relatives may be burdensome. Special attention should be paid to communication of LS to more distant relatives.

  9. How does genetic risk information for Lynch syndrome translate to risk management behaviours?

    Science.gov (United States)

    Steel, Emma; Robbins, Andrew; Jenkins, Mark; Flander, Louisa; Gaff, Clara; Keogh, Louise

    2017-01-01

    There is limited research on why some individuals who have undergone predictive genetic testing for Lynch syndrome do not adhere to screening recommendations. This study aimed to explore qualitatively how Lynch syndrome non-carriers and carriers translate genetic risk information and advice to decisions about risk managment behaviours in the Australian healthcare system. Participants of the Australasian Colorectal Cancer Family Registry who had undergone predictive genetic testing for Lynch syndrome were interviewed on their risk management behaviours. Transcripts were analysed thematically using a comparative coding analysis. Thirty-three people were interviewed. Of the non-carriers (n = 16), 2 reported having apparently unnecessary colonoscopies, and 6 were unsure about what population-based colorectal cancer screening entails. Of the carriers (n = 17), 2 reported they had not had regular colonoscopies, and spoke about their discomfort with the screening process and a lack of faith in the procedure's ability to reduce their risk of developing colorectal cancer. Of the female carriers (n = 9), 2 could not recall being informed about the associated risk of gynaecological cancers. Non-carriers and female carriers of Lynch syndrome could benefit from further clarity and advice about appropriate risk management options. For those carriers who did not adhere to colonoscopy screening, a lack of faith in both genetic test results and screening were evident. It is essential that consistent advice is offered to both carriers and non-carriers of Lynch syndrome.

  10. Translation and Creative Writing: An Interview with Professor Margaret Rogers

    Directory of Open Access Journals (Sweden)

    Ruzbeh Babaee

    2016-01-01

    Full Text Available Introduction This interview was conducted with Emerita Professor Margaret Rogers with the aim of providing a brief but informative summary of the relationship between translation and creative writing. Emerita Professor Rogers is in the Centre for Translation Studies, School of English and Languages, University of Surrey, UK. She is also the founder of Terminology Network at the Institute of Translation and Interpreting in the UK. Professor Rogers introduced creative writing into the translation curriculum some 10 years ago at her own university.   The Interview   RB[1]: Do you believe in a theory of translation? MR[2]: There are many ways of trying to understand and, where we can, explain translation in all its guises, loci and times. To talk about ‘a theory’ in this context doesn’t help much. There are many different approaches to the academic study of translation: rather simply put, the particular approach which we choose to adopt may depend on our object of study (e.g. literary translation or specialised translation, what we want to find out about this (e.g. are we interested in product or process, in a historical or contemporary perspective, what resources we have available (e.g. a fully funded research team or a solo effort and so on. Many projects are interdisciplinary—this has long been recognised—and translation scholars are becoming much more resourceful in identifying, adopting and adapting relevant approaches from intersecting disciplines such as comparative literature, cultural studies, history, linguistics, philosophy, psychology and sociology. Some scholars are now advocating a problem-based approach. In any research project it is important to establish how the problem/phenomenon/issue which has been identified as the focus of the study can be tackled. For this, in an empirical study a method is crucial: in translation studies this is rarely something that can be picked off the shelf and is often a contribution to the

  11. Clinicopathological Features of Endometrial Carcino-ma Associated with Lynch Syndrome in China

    Institute of Scientific and Technical Information of China (English)

    Yingmei WANG; Fengxia XUE; Russell R. BROADDUS; Xia TAO; Susu XIE; Yanbin ZHU

    2009-01-01

    Background and objective To study the clinicopathoiogical characteristics of Lynch syn&ome-associated endometrial carcinoma in China.Methods Twenty-seven patients who fulfilled the Amsterdam Criteria Ⅱ were classified as having Lynch syndrome-associated endometrial carcinoma (Group A), and 331 patients without a family history of cancer were classified as having sporadic endometrial carcinoma (Group B).Results There were 81 malignancies in 27 Lynch syndrome-associated endometrial carcinoma families, including colorectal cancer (CRC, 24.7%), endometrial carcinoma (21.0%), liver (12.3%), stomach (9.9%), lung (6.2%), and breast (6.2%) cancers. Mean age at time of diagnosis was 49.7 years in Group A and 56.3 years in Group B (P=0.004). Second primary cancers occurred in 33.3% of patients in Group A and 5.1% in Group B (P<0.0001). "Ihe most common second primary cancers were colorectal cancer (44%) and ovarian cancer (22%). The percentage of obese patients was higher in Group A (P=0.013). There was no difference between the two groups in incidence of diabetes mellitns or hypertension or in histological type and FIGO stage. The 5-year survival rates for Group A and B were 96.2% and 79.6%, respectively. Prognosis for Group A was better than for Group B (P=0.045).Conclusion Some clinicopathologicai features of Lynch syndrome-associated endometrial carcinoma, such as early onset and multiple primary carcinomas, are similar in the Chinese and American/European populations. However, the Chinese population had a unique family cancer distribution that included lung and breast cancers. An increased number of grade 1 endometrioid tumors and a better prognosis imply better biobehavior in Chinese Lynch syndrome-associated endometrial carcinoma. Obesity may be a co-contributing factor for development of Lynch syndrome associated endometrial cancer in China.

  12. Margaret Murray (1863–1963: Pioneer Egyptologist, Feminist and First Female Archaeology Lecturer

    Directory of Open Access Journals (Sweden)

    Ruth Whitehouse

    2013-10-01

    Full Text Available Margaret Murray, who was born 150 years ago, was one of the first archaeologists to be employed at UCL and one of the most distinguished, although her role in the history of archaeology is often underestimated. This article provides a brief outline of the career and contribution of a highly productive and innovative, if sometimes controversial, scholar, who also participated in the wider social movements of her time, particularly the campaign for women’s suffrage.

  13. Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome

    DEFF Research Database (Denmark)

    Drost, Mark; Lützen, Anne; van Hees, Sandrine

    2013-01-01

    In many individuals suspected of the common cancer predisposition Lynch syndrome, variants of unclear significance (VUS), rather than an obviously pathogenic mutations, are identified in one of the DNA mismatch repair (MMR) genes. The uncertainty of whether such VUS inactivate MMR, and therefore...... for the translation of personalized genomics into targeted healthcare....

  14. Informing family members of individuals with Lynch syndrome : a guideline for clinical geneticists

    NARCIS (Netherlands)

    Menko, Fred H.; Aalfs, Cora M.; Henneman, Lidewij; Stol, Yrrah; Wijdenes, Miranda; Otten, Ellen; Ploegmakers, Marleen M. J.; Legemaate, Johan; Smets, Ellen M. A.; de Wert, Guido M. W. R.; Tibben, Aad

    2013-01-01

    The diagnosis of Lynch syndrome can lead to the prevention of colorectal cancer through periodic colonoscopies and removal of premalignant lesions in susceptible individuals. Therefore, predisposed individuals identified by mutation analysis are advised to inform their at-risk relatives about the op

  15. Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance

    DEFF Research Database (Denmark)

    Møller, Pål; Seppälä, Toni; Bernstein, Inge;

    2016-01-01

    OBJECTIVE: Estimates of cancer risk and the effects of surveillance in Lynch syndrome have been subject to bias, partly through reliance on retrospective studies. We sought to establish more robust estimates in patients undergoing prospective cancer surveillance. DESIGN: We undertook a multicentr...

  16. The Kids Are (Mostly) Alright: Second-Generation Assimilation--Comments on Haller, Portes and Lynch

    Science.gov (United States)

    Alba, Richard; Kasinitz, Philip; Waters, Mary C.

    2011-01-01

    This paper presents the authors' comments on "Dreams Fulfilled, Dreams Shattered: Determinants of Segmented Assimilation in the Second Generation" by William Haller, Alejandro Portes and Scott M. Lynch. The overall well-being and integration of second-generation immigrant youth constitute an important topic for researchers and policy makers, one…

  17. Gene variants of unknown clinical significance in Lynch syndrome. An introduction for clinicians

    NARCIS (Netherlands)

    Sijmons, Rolf H.; Greenblatt, Marc S.; Genuardi, Maurizio

    2013-01-01

    Clinicians referring patients for genetic testing for Lynch syndrome will sooner or later receive results for DNA Mismatch Repair (MMR) genes reporting DNA changes that are unclear from a clinical point of view. These changes are referred to as variants of unknown, or unclear, clinical significance

  18. Prediction of MLH1 and MSH2 mutations in lynch syndrome

    NARCIS (Netherlands)

    J. Balmana (Judith); D.H. Stockwell (David); E.W. Steyerberg (Ewout); E.M. Stoffel (Elena); A.M. Deffenbaugh (Amie); J.E. Reid (Julia); B. Ward (Brian); T. Scholl (Thomas); B. Hendrickson (Brant); J. Tazelaar (John); L.A. Burbidge (Lynn); S. Syngal (Sapna)

    2006-01-01

    textabstractContext: Lynch syndrome is caused primarily by mutations in the mismatch repair genes MLH1 and MSH2. Objectives: To analyze MLH1/MSH2 mutation prevalence in a large cohort of patients undergoing genetic testing and to develop a clinical model to predict the likelihood of finding a mutati

  19. Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome

    NARCIS (Netherlands)

    J. Burn (John); D.T. Bishop (David Timothy); J.-P. Mecklin (Jukka-Pekka); F.A. Macrae (Finlay); G. Möslein (Gabriela); S. Olschwang (Sylviane); M.-L. Bisgaard (Marie-Luise); R.S. Ramesar (Rajkumar); D. Eccles (Diana); E.R. Maher (Eamonn); L. Bertario (Lucio); H.J. Jarvinen (Heikki); A. Lindblom (Annika); D.G. Evans (Gareth); J. Lubinski (Jan); P.J. Morrison (Patrick); J.W.C. Ho (Judy); H. Vasen (Hans); L. Side (Lucy); H.J.W. Thomas (Huw ); R.J. Scott (Rodney); M.G. Dunlop (Malcolm); G. Barker (Gail); F. Elliott (Faye); J.R. Jass (Jeremy ); R. Fodde (Riccardo); H. Lynch (Henry); J.C. Mathers (John )

    2008-01-01

    textabstractBACKGROUND: Observational and epidemiologic data indicate that the use of aspirin reduces the risk of colorectal neoplasia; however, the effects of aspirin in the Lynch syndrome (hereditary nonpolyposis colon cancer) are not known. Resistant starch has been associated with an antineoplas

  20. Is surveillance of the small bowel indicated for Lynch syndrome families?

    NARCIS (Netherlands)

    Kate, G.L. ten; Kleibeuker, J.H.; Nagengast, F.M.; Craanen, M.; Cats, A.; Menko, F.H.; Vasen, H.F.

    2007-01-01

    BACKGROUND: Small bowel cancer (SBC) is one of the tumours associated with Lynch syndrome (LS). To advise on screening for this tumour it is paramount to be informed about the lifetime risk. The aim of this study was to calculate the lifetime risk of SBC in LS and to identify possible risk factors.

  1. Is surveillance of the small bowel indicated for Lynch syndrome families?

    NARCIS (Netherlands)

    ten Kate, G. L.; Kleibeuker, J. H.; Nagengast, F. M.; Craanen, M.; Cats, A.; Menko, F. H.; Vasen, H. F. A.

    2007-01-01

    Background: Small bowel cancer (SBC) is one of the tumours associated with Lynch syndrome (LS). To advise on screening for this tumour it is paramount to be informed about the lifetime risk. The aim of this study was to calculate the lifetime risk of SBC in LS and to identify possible risk factors.

  2. Dietary patterns and colorectal adenomas in Lynch syndrome: the GEOLynch cohort study

    NARCIS (Netherlands)

    Botma, A.; Vasen, H.F.; Duijnhoven, F.J.B. van; Kleibeuker, J.H.; Nagengast, F.M.; Kampman, E.

    2013-01-01

    BACKGROUND: Patients with Lynch syndrome (LS) have a high risk of developing colorectal cancer due to mutations in mismatch repair genes. Because dietary factors, alone and in combination, influence sporadic colorectal carcinogenesis, the association of dietary patterns with colorectal adenomas in L

  3. Dietary Patterns and Colorectal Adenomas in Lynch Syndrome The GEOLynch Cohort Study

    NARCIS (Netherlands)

    Botma, Akke; Vasen, Hans F. A.; van Duijnhoven, Franzel J. B.; Kleibeuker, Jan H.; Nagengast, Fokko M.; Kampman, Ellen

    2013-01-01

    BACKGROUND: Patients with Lynch syndrome (LS) have a high risk of developing colorectal cancer due to mutations in mismatch repair genes. Because dietary factors, alone and in combination, influence sporadic colorectal carcinogenesis, the association of dietary patterns with colorectal adenomas in L

  4. Smoking increases the risk for colorectal adenomas in patients with Lynch syndrome

    NARCIS (Netherlands)

    Winkels, R.M.; Botma, A.; Duijnhoven, van F.J.B.; Nagengast, F.M.; Kleibeuker, J.H.; Vasen, H.F.A.; Kampman, E.

    2012-01-01

    Background & Aims Individuals with Lynch syndrome have a high risk of developing colorectal carcinomas and adenomas at a young age, due to inherited mutations in mismatch repair genes. We investigated whether modifiable lifestyle factors, such as smoking and alcohol intake, increase this risk.

  5. Smoking Increases the Risk for Colorectal Adenomas in Patients With Lynch Syndrome

    NARCIS (Netherlands)

    Winkels, Renate M.; Botma, Akke; Van Duijnhoven, Franzel J. B.; Nagengast, Fokko M.; Kleibeuker, Jan H.; Vasen, Hans F. A.; Kampman, Ellen

    BACKGROUND & AIMS: Individuals with Lynch syndrome have a high risk of developing colorectal carcinomas and adenomas at a young age, due to inherited mutations in mismatch repair genes. We investigated whether modifiable lifestyle factors, such as smoking and alcohol intake, increase this risk.

  6. A frame-shift mutation of PMS2 is a widespread cause of Lynch syndrome

    DEFF Research Database (Denmark)

    Clendenning, Mark; Senter, Leigha; Hampel, Heather;

    2008-01-01

    on immunohistochemical analysis. RESULTS: We have identified a frequently occurring frame-shift mutation (c.736_741del6ins11) in 12 ostensibly unrelated Lynch syndrome patients (20% of patients we have identified with a deleterious mutation in PMS2, n=61). These individuals all display the rare allele (population...

  7. Lynch, Urry and city marketing: Taking advantage of the city as a built and graphic image

    NARCIS (Netherlands)

    Hospers, G-J.

    2009-01-01

    City marketing is usually addressed from the perspective of marketing theory. This article follows an alternative approach by exploring city marketing from the viewpoint of urban planning and the sociology of tourism. In his classic ‘The Image of the City’ (1960), planner Kevin Lynch found that peop

  8. Smoking increases the risk for colorectal adenomas in patients with Lynch syndrome

    NARCIS (Netherlands)

    Winkels, R.M.; Botma, A.; Duijnhoven, van F.J.B.; Nagengast, F.M.; Kleibeuker, J.H.; Vasen, H.F.A.; Kampman, E.

    2012-01-01

    Background & Aims Individuals with Lynch syndrome have a high risk of developing colorectal carcinomas and adenomas at a young age, due to inherited mutations in mismatch repair genes. We investigated whether modifiable lifestyle factors, such as smoking and alcohol intake, increase this risk. M

  9. Smoking Increases the Risk for Colorectal Adenomas in Patients With Lynch Syndrome

    NARCIS (Netherlands)

    Winkels, Renate M.; Botma, Akke; Van Duijnhoven, Franzel J. B.; Nagengast, Fokko M.; Kleibeuker, Jan H.; Vasen, Hans F. A.; Kampman, Ellen

    2012-01-01

    BACKGROUND & AIMS: Individuals with Lynch syndrome have a high risk of developing colorectal carcinomas and adenomas at a young age, due to inherited mutations in mismatch repair genes. We investigated whether modifiable lifestyle factors, such as smoking and alcohol intake, increase this risk. METH

  10. Smoking increases the risk for colorectal adenomas in patients with Lynch syndrome.

    NARCIS (Netherlands)

    Winkels, R.M.; Botma, A.; Duijnhoven, F.J.B. van; Nagengast, F.M.; Kleibeuker, J.H.; Vasen, H.F.; Kampman, E.

    2012-01-01

    BACKGROUND & AIMS: Individuals with Lynch syndrome have a high risk of developing colorectal carcinomas and adenomas at a young age, due to inherited mutations in mismatch repair genes. We investigated whether modifiable lifestyle factors, such as smoking and alcohol intake, increase this risk. METH

  11. Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer).

    NARCIS (Netherlands)

    Vasen, H.F.; Moslein, G.; Alonso, A.; Bernstein, I.; Bertario, L.; Blanco, I.; Burn, J.; Capella, G.; Engel, C.; Frayling, I.; Friedl, W.; Hes, F.J.; Hodgson, S.; Mecklin, J.P.; Moller, P.; Nagengast, F.M.; Parc, Y.; Renkonen-Sinisalo, L.; Sampson, J.R.; Stormorken, A.; Wijnen, J.

    2007-01-01

    Lynch syndrome (hereditary non-polyposis colorectal cancer) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. The discovery of these genes, 15 years ago,

  12. The InSiGHT database : utilizing 100 years of insights into Lynch Syndrome

    NARCIS (Netherlands)

    Plazzer, J. P.; Sijmons, R. H.; Woods, M. O.; Peltomaki, P.; Thompson, B.; Den Dunnen, J. T.; Macrae, F.

    2013-01-01

    This article provides a historical overview of the online database (www.insight-group.org/mutations) maintained by the International Society for Gastrointestinal Hereditary Tumours. The focus is on the mismatch repair genes which are mutated in Lynch Syndrome. APC, MUTYH and other genes are also an

  13. HEREDITARY NON-POLYPOSIS COLORECTAL CANCER (LYNCH SYNDROME PADA WANITA UMUR 16 TAHUN

    Directory of Open Access Journals (Sweden)

    Asril Zahari

    2011-09-01

    Full Text Available AbstrakKanker kolorektal menduduki peringkat ketiga jenis kanker yang paling sering terjadi di dunia. Sekitar 3% kasus kanker kolorektal merupakan jenis hereditary non polyposis colorectal cancer (HNPCC/Lynch syndrome, yang sering muncul pada usia muda. Dilaporkan satu kasus di rumah sakit Dr. M. Djamil Padang, wanita berumur 16 tahun dengan keluhan nyeri perut kanan bawah. Didapatkan riwayat penyakit serupa pada kakek, bibi pasien dan enam anggota keluarga yang lain. Pada pemeriksaan fisik abdomen teraba massa dengan konsistensi keras dan terfiksir. Pada kolonoskopi dan biopsi ditemukan tumor jenis adenocarcinoma colon moderatly differentiated di fleksura hepatika dan polip di kolon sigmoid. Berdasarkan kriteria Amsterdam pasien didiagnosa Lynch syndrome. Pada Pasien dilakukan subtotal kolektomi, anastomose ileorectal dan kemoterapi ajuvan. Identifikasi genetik sedang dikerjakan untuk melihat adanya kelainan genetik pada pasien. Pasien melakukan skrining berkala untuk mencegah kanker HNPCC jenis yang lain.Kata kunci : Hereditary non polyposis colorectal cancer, Lynch syndrome, Microsatellite instability, skrining.AbstractCarcinoma colorectal is the third most common type of cancer that occurs in the world. About 2% -3% of cases of colorectal cancer is hereditary non-polyposis colorectal cancer (HNPCC/Lynch syndrome, which often appear at a young age. Amsterdam and Bethesda criteria have been used to identify patients with Lynch syndrome.one case was reported at the Dr. M. Djamil Padang hospital, a 16-year-old girl with right lower abdominal pain. Obtained a history of similar disease in grandparents, aunts and six other family members. On physical examination found palpable fixed abdominal mass with hard consistency in the lower right abdomen. At colonoscopy and biopsy found a moderatly differentiated adenocarcinoma colon type at the hepatic flexure and the sigmoid colon polyp. Based on the Amsterdam criteria, patients diagnosed with HNPCC/Lynch

  14. Limited impact on self-concept in individuals with Lynch syndrome; results from a national cohort study

    DEFF Research Database (Denmark)

    Petersen, Helle Vendel; Esplen, Mary Jane; Ladelund, Steen;

    2011-01-01

    An increasing number of individuals seek genetic counseling and hereby learn about hereditary cancer in the family. Lynch syndrome is associated with an inherited high risk for colorectal and gynecological cancer, but knowledge about how family members at risk perceive their situation is limited....... We used the national Danish HNPCC register to collect data on self-concept from 413 individuals with Lynch syndrome. The recently developed Lynch syndrome self-concept scale contains 20 items within two subscales related to stigma-vulnerability and bowel symptom-related anxiety. Significantly higher...

  15. The post-perspectival: screens and time in David Lynch's Inland Empire

    Directory of Open Access Journals (Sweden)

    Anne Jerslev

    2012-03-01

    Full Text Available Taking Anne Friedberg's notion of the post-perspectival as the point of departure for her analysis of David Lynch's digitally shot and edited Inland Empire from 2006, Anne Jerslev argues that the film deconstructs continuous time and coherent space by constructing multiple planes of representation, multiple layerings of screens and, hence, multiple and fractured modes of perception. The article further suggests that the film's enigmatic structure might best be understood with reference to a new media genre like the website with its hyperlink structure. Finally, the article discusses how a sense of ubiquitous surveillance coalesces with the screen logic.Author Biography Anne Jerslev (PhD is Professor of Film and Media Studies at the Department of Media, Cognition and Communication, University of Copenhagen. Anne Jerslev has published and edited books in Danish and English and published dozens of articles in journals and anthologies in Danish, Scandinavian languages, German and English. Her first book was titled David Lynch i vore øjne (David Lynch in our eyes (1991; it was published in German in 1995 under the title David Lynch—mentale Landschaften. After the Lynch book she published books about cult movies, youth and media and media and intimacy. She has edited two volumes in English, Realism and Reality in Film and Media (2002, where she contributed a piece about Lars von Trier's The Idiots, and Performative Realism (co-edited with Rune Gade (2005. Her latest edited volume (co-edited with Christa Lykke Christensen is Hvor går grænsen? Brudflader i den moderne mediekultur [Are there no limits? The crossing of boundaries in contemporary media culture] (Copenhagen 2010. She is currently editing a volume about “Impure Cinema” together with professor Lúcia Nagib from the University of Leeds, which will appear in 2013. Her own contribution to the book is an article about David Lynch's Interview Project.

  16. A very large soul: selected letters from Margaret Laurence to Canadian writers A very large soul: selected letters from Margaret Laurence to Canadian writers

    Directory of Open Access Journals (Sweden)

    John J. O'Connor

    2008-04-01

    Full Text Available “This will be a brief letter, as I have a horrifying stack of business letters to catch up on,” wrote Margaret Laurence to her friend and fellow novelist Gabrielle Roy in 1978, echoing an earlier lament to her epistolary friend Ernest Buckler about the need to “keep pace with the ghastly flow of business correspondence.” Although she was always to face some tension between her personal and professional selves as correspondent, her priority was never in question: “Must go. I have 70 letters to reply to, having got far behind in correspondence ... am trying now to communicate once again with dear friends first, and then to answer all the others, which will no doubt be my winter project” (4 Sept. 1974 letter to Silver Donald Cameron. “This will be a brief letter, as I have a horrifying stack of business letters to catch up on,” wrote Margaret Laurence to her friend and fellow novelist Gabrielle Roy in 1978, echoing an earlier lament to her epistolary friend Ernest Buckler about the need to “keep pace with the ghastly flow of business correspondence.” Although she was always to face some tension between her personal and professional selves as correspondent, her priority was never in question: “Must go. I have 70 letters to reply to, having got far behind in correspondence ... am trying now to communicate once again with dear friends first, and then to answer all the others, which will no doubt be my winter project” (4 Sept. 1974 letter to Silver Donald Cameron.

  17. Comprehensive population-wide analysis of Lynch syndrome in Iceland reveals founder mutations in MSH6 and PMS2

    DEFF Research Database (Denmark)

    Haraldsdottir, Sigurdis; Rafnar, Thorunn; Frankel, Wendy L

    2017-01-01

    Lynch syndrome, caused by germline mutations in the mismatch repair genes, is associated with increased cancer risk. Here using a large whole-genome sequencing data bank, cancer registry and colorectal tumour bank we determine the prevalence of Lynch syndrome, associated cancer risks...... hypermethylation or mutations in the mismatch repair genes. The population prevalence of Lynch syndrome is 0.442%. We discover a translocation disrupting MLH1 and three mutations in MSH6 and PMS2 that increase endometrial, colorectal, brain and ovarian cancer risk. We find thirteen mismatch repair variants...... and pathogenicity of several variants in the Icelandic population. We use colorectal cancer samples from 1,182 patients diagnosed between 2000-2009. One-hundred and thirty-two (11.2%) tumours are mismatch repair deficient per immunohistochemistry. Twenty-one (1.8%) have Lynch syndrome while 106 (9.0%) have somatic...

  18. Gibraltar Experiment CTD data report, USNS Lynch, 1986-03-26 to 1986-04-19 (NODC Accession 8800167)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile, ocean circulation, and chemical data were collected using CTD casts from the USNS LYNCH in the Gulf of Cadiz, Alboran Sea, and Strait of...

  19. Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer.

    Science.gov (United States)

    Giardiello, Francis M; Allen, John I; Axilbund, Jennifer E; Boland, C Richard; Burke, Carol A; Burt, Randall W; Church, James M; Dominitz, Jason A; Johnson, David A; Kaltenbach, Tonya; Levin, Theodore R; Lieberman, David A; Robertson, Douglas J; Syngal, Sapna; Rex, Douglas K

    2014-08-01

    The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3-6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided.

  20. Doing Violence, Making Race: Southern Lynching and White Racial Group Formation.

    Science.gov (United States)

    Smångs, Mattias

    2016-03-01

    This article presents a theoretical framework of how intergroup violence may figure into the activation and maintenance of group categories, boundaries, and identities, as well as the mediating role played by organizations in such processes. The framework's analytical advantages are demonstrated in an application to southern lynchings. Findings from event- and community-level analyses suggest that "public" lynchings, carried out by larger mobs with ceremonial violence, but not "private" ones, perpetrated by smaller bands without public or ceremonial violence, fed off and into the racial group boundaries, categories, and identities promoted by the southern Democratic Party at the turn of the 20th century and on which the emerging Jim Crow system rested. Highlighting that racialized inequalities cannot be properly understood apart from collective processes of racial group boundary and identity making, the article offers clues to the mechanisms by which past racial domination influences contemporary race relations.

  1. Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome

    DEFF Research Database (Denmark)

    Burn, John; Bishop, D Timothy; Mecklin, Jukka-Pekka

    2008-01-01

    .4%) (relative risk, 1.0; 95% CI, 0.7 to 1.4). Advanced adenomas and colorectal cancers were evenly distributed in the two groups. The prevalence of serious adverse events was low, and the events were evenly distributed. CONCLUSIONS: The use of aspirin, resistant starch, or both for up to 4 years has no effect......BACKGROUND: Observational and epidemiologic data indicate that the use of aspirin reduces the risk of colorectal neoplasia; however, the effects of aspirin in the Lynch syndrome (hereditary nonpolyposis colon cancer) are not known. Resistant starch has been associated with an antineoplastic effect...... on the incidence of colorectal adenoma or carcinoma among carriers of the Lynch syndrome. (Current Controlled Trials number, ISRCTN59521990.)...

  2. [Management and Nursing care for a patient with Lynch syndrome: A case report].

    Science.gov (United States)

    Pacheco-Pérez, Luis Arturo; Guevara Valtier, Milton Carlos

    2016-01-01

    Colorectal cancer is one of the leading causes of death from cancer worldwide. Main interventions to reduce the impact are aimed to enhance prevention and early detection. Results of several studies show that tests such as the fecal occult blood test and colonoscopy are effective for early diagnosis. There are hereditary syndromes such as Lynch Syndrome that can lead to certain types of cancers, including bowel neoplasms, therefore early detection needs to be included as part of the treatment. In these cases, family genetic testing is recommended if the bowel cancer is diagnosed before 50 years old. A care plan including the NANDA (North American Nursing Diagnosis Association), NOC (Nursing Outcomes Classification) and NIC (Nursing Interventions Classification) was developed for a patient with suspected Lynch Syndrome. Nurses should be qualified to identify potential cases of cancer associated with this syndrome, and thus, reduce the likelihood that family members develop the disease, through genetic counseling and education of environmental risk factors.

  3. Urinary Tract Cancer in Lynch Syndrome; Increased Risk in Carriers of MSH2 Mutations

    DEFF Research Database (Denmark)

    Joost, Patrick; Therkildsen, Christina; Dominguez-Valentin, Mev

    2015-01-01

    nonpolyposis colorectal cancer registry was used to identify all 288 Lynch syndrome families in Denmark. Urothelial cancers that developed in mutation carriers and in their first-degree relatives were identified, mismatch-repair status was assessed, clinicopathologic variables were defined, and cumulative......OBJECTIVE: To evaluate the risk of urothelial cancer in the upper urinary tract and the bladder, determine the contribution from the different mismatch-repair genes, and define clinical characteristics of urothelial cancer in Lynch syndrome. MATERIALS AND METHODS: The national hereditary...... lifetime risks were determined. RESULTS: In total, 48 cancers of the ureter, 34 cancers of the renal pelvis, and 54 urinary bladder cancers developed at a mean age of 61 (24-89) years. The tumors were typically of high grade, showed loss of mismatch-repair protein expression in 90% of the tumors...

  4. Parallels in the Beliefs and Works of Margaret Fuller and Carl Jung

    Directory of Open Access Journals (Sweden)

    Jerry Aldridge

    2011-05-01

    Full Text Available Margaret Fuller, the 19th-century feminist and Transcendentalist, has been compared with Louisa May Alcott, Ralph Waldo Emerson, Nathaniel Hawthorne, and Henry David Thoreau. The life and theories of Carl Jung, the 20th-century psychiatrist, have been compared with the works of Sigmund Freud, Alfred Adler, Jean Piaget, and Sabina Spielrein among others. However, no comparisons have been published concerning the beliefs and works of Fuller and Jung. The purpose of this research was to compare and contrast the beliefs and written works of Margaret Fuller and Carl Jung. Similarities and differences were reported among their ideologies. Similarities in their childhood and adult dreams, literary references, spiritual beliefs, and explorations of gender were described. Differences were reported, which included the focus of their writings and their ideas about who is to blame when things go wrong, and how to deal with the individual daemon in each person was also explored. Special consideration was given to how closely their writings intersect. Specifically, the authors questioned whether Jung was inspired by the ideas and writings of Fuller. To answer this question, five possibilities were identified.

  5. Lynch syndrome: barriers to and facilitators of screening and disease management

    Directory of Open Access Journals (Sweden)

    Watkins Kathy E

    2011-09-01

    Full Text Available Abstract Background Lynch syndrome is a hereditary cancer with confirmed carriers at high risk for colorectal (CRC and extracolonic cancers. The purpose of the current study was to develop a greater understanding of the factors influencing decisions about disease management post-genetic testing. Methods The study used a grounded theory approach to data collection and analysis as part of a multiphase project examining the psychosocial and behavioral impact of predictive DNA testing for Lynch syndrome. Individual and small group interviews were conducted with individuals from 10 families with the MSH2 intron 5 splice site mutation or exon 8 deletion. The data from confirmed carriers (n = 23 were subjected to re-analysis to identify key barriers to and/or facilitators of screening and disease management. Results Thematic analysis identified personal, health care provider and health care system factors as dominant barriers to and/or facilitators of managing Lynch syndrome. Person-centered factors reflect risk perceptions and decision-making, and enduring screening/disease management. The perceived knowledge and clinical management skills of health care providers also influenced participation in recommended protocols. The health care system barriers/facilitators are defined in terms of continuity of care and coordination of services among providers. Conclusions Individuals with Lynch syndrome often encounter multiple barriers to and facilitators of disease management that go beyond the individual to the provider and health care system levels. The current organization and implementation of health care services are inadequate. A coordinated system of local services capable of providing integrated, efficient health care and follow-up, populated by providers with knowledge of hereditary cancer, is necessary to maintain optimal health.

  6. Lynch syndrome: barriers to and facilitators of screening and disease management.

    Science.gov (United States)

    Watkins, Kathy E; Way, Christine Y; Fiander, Jacqueline J; Meadus, Robert J; Esplen, Mary Jane; Green, Jane S; Ludlow, Valerie C; Etchegary, Holly A; Parfrey, Patrick S

    2011-09-07

    Lynch syndrome is a hereditary cancer with confirmed carriers at high risk for colorectal (CRC) and extracolonic cancers. The purpose of the current study was to develop a greater understanding of the factors influencing decisions about disease management post-genetic testing. The study used a grounded theory approach to data collection and analysis as part of a multiphase project examining the psychosocial and behavioral impact of predictive DNA testing for Lynch syndrome. Individual and small group interviews were conducted with individuals from 10 families with the MSH2 intron 5 splice site mutation or exon 8 deletion. The data from confirmed carriers (n = 23) were subjected to re-analysis to identify key barriers to and/or facilitators of screening and disease management. Thematic analysis identified personal, health care provider and health care system factors as dominant barriers to and/or facilitators of managing Lynch syndrome. Person-centered factors reflect risk perceptions and decision-making, and enduring screening/disease management. The perceived knowledge and clinical management skills of health care providers also influenced participation in recommended protocols. The health care system barriers/facilitators are defined in terms of continuity of care and coordination of services among providers. Individuals with Lynch syndrome often encounter multiple barriers to and facilitators of disease management that go beyond the individual to the provider and health care system levels. The current organization and implementation of health care services are inadequate. A coordinated system of local services capable of providing integrated, efficient health care and follow-up, populated by providers with knowledge of hereditary cancer, is necessary to maintain optimal health.

  7. Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with Lynch syndrome.

    Science.gov (United States)

    Reuschenbach, Miriam; Kloor, Matthias; Morak, Monika; Wentzensen, Nicolas; Germann, Anja; Garbe, Yvette; Tariverdian, Mirjam; Findeisen, Peter; Neumaier, Michael; Holinski-Feder, Elke; von Knebel Doeberitz, Magnus

    2010-06-01

    High level microsatellite instability (MSI-H) occurs in about 15% of colorectal cancer (CRCs), either as sporadic cancers or in the context of hereditary non-polyposis cancer or Lynch syndrome. In MSI-H CRC, mismatch repair deficiency leads to insertion/deletion mutations at coding microsatellites and thus to the translation of frameshift peptides (FSPs). FSPs are potent inductors of T cell responses in vitro and in vivo. The present study aims at the identification of FSP-specific humoral immune responses in MSI-H CRC and Lynch syndrome. Sera from patients with history of MSI-H CRC (n = 69), healthy Lynch syndrome mutation carriers (n = 31) and healthy controls (n = 52) were analyzed for antibodies against FSPs using peptide ELISA. Reactivities were measured against FSPs derived from genes frequently mutated in MSI-H CRCs, AIM2, TGFBR2, CASP5, TAF1B, ZNF294, and MARCKS. Antibody reactivity against FSPs was significantly higher in MSI-H CRC patients than in healthy controls (P = 0.036, Mann-Whitney) and highest in patients with shortest interval between tumor resection and serum sampling. Humoral immune responses in patients were most frequently directed against FSPs derived from mutated TAF1B (11.6%, 8/69) and TGFBR2 (10.1%, 7/69). Low level FSP-specific antibodies were also detected in healthy mutation carriers. Our results show that antibody responses against FSPs are detectable in MSI-H CRC patients and healthy Lynch syndrome mutation carriers. Based on the high number of defined FSP antigens, measuring FSP-specific humoral immune responses is a highly promising tool for future diagnostic application in MSI-H cancer patients.

  8. Stay the Night: Meera Margaret Singh at the Gladstone Hotel Stay the Night : Meera Margaret Singh à l’hôtel Gladstone

    Directory of Open Access Journals (Sweden)

    Kerry Manders

    2012-07-01

    Full Text Available This essay examines Meera Margaret Singh’s exhibition Nightingale in the time and place of the liminal space we call “hotel.” In intertexual dialogue with Wayne Koestenbaum’s Hotel Theory, the author not only reviews Singh’s intimate photographs of her mother, she reads the images with and against the architecture in which they are exhibited. The Gladstone as exhibition space redoubles Singh’s emphasis on the tense connectivity of apparent binaries: youth and age, public and private, artist and model, object and spectator, living and dying. The quotidian activities of hotel living—guests’ arrivals, departures, and returns—become inextricable pieces of Singh’s site-specific installation. The author theorizes what Freud calls the “foretaste of mourning” in this work, grappling with what will be but is not yet the death of the mother. Singh’s Nightingale proposes that we do not “work through” mourning: mourning is a perpetual way of being in the present.Cet article examine l’exposition photographique de Meera Margaret Singh dans l’espace liminal qu’est l’hôtel. En dialogue intertextuel avec l’œuvre de Wayne Koestenbaum, Hotel Theory, l’auteur examine les portraits intimes de la mère de la photographe, tout en les lisant en fonction de l’architecture de leur emplacement. L’hôtel Gladstone en tant que lieu d’exposition redouble donc l’accent que met la photographe sur les liens tendus des systèmes binaires apparents: la jeunesse et l’âge ; le public et le privé ; l’artiste et le modèle ; l’objet et le spectateur; vivre et mourir. Les activités quotidiennes de la vie en hôtel – l’arrivée, le départ, et le retour d’invités – deviennent des éléments inextricables de l’œuvre in situ. L’auteur théorise le concept de Freud sur l’avant-goût du deuil, explorant ce qui deviendra mais ne l’est pas encore : la mort de la mère. Cette exposition propose que nous ne

  9. Margaret Thatcher et la BBC : régulation ou manipulation ? Margaret Thatcher and the BBC: Regulation or Manipulation?

    Directory of Open Access Journals (Sweden)

    Daniel Ruff

    2009-10-01

    Full Text Available This article argues that the relationship between Margaret Thatcher and her governments of the 1980s on the one hand, and the BBC on the other, differed from those of an ‘arm’s length’ regulator which had existed since the creation of the BBC through successive Conservative and Labour governments until 1979, in which ministers would not intervene in BBC policy or programming. Ministers and party members instituted a concerted attempt to intimidate the BBC, most especially its news and current affairs programmes, whenever the latter did not report national politics and international events to the government’s liking. Proposed neo-liberal reforms to the system of funding the Corporation and negotiations for regular increases in the value of the licence fee were similarly opportunities to exert pressure on the BBC and to call into question its public service remit. Finally, royal prerogative and royal patronage were used to manipulate the political colour of the Board of Governors and thus, indirectly, the management of the BBC.

  10. SOME CLASSICAL HYPOTEXTS IN MARGARET DOODY’S ARISTOTLE AND POETIC JUSTICE

    Directory of Open Access Journals (Sweden)

    F. Pauw

    2012-03-01

    Full Text Available

    The philosopher Aristotle appears in seven detective novels by the academic Margaret Doody in which he makes use of hisinvestigative powers to solve murder mysteries. In Aristotle andpoetic justice Stephanos, a friend of Aristotle, narrates how Anthia, the heiress of a silver merchant, has been abducted. While Stephanosand Aristotle pursue the abductor and the heiress on the road to Delphi, two murders complicate their challenge.

    Doody’s novel provides a convenient framework for opening awindow onto the Greek world of 330 BC. In the body of the article,hypertextual allusions introduced by Doody are examined andevaluated, using a modified version of Genette’s scheme ashermeneutic paradigm.

  11. Margaret archer versus la sociología clásica"

    OpenAIRE

    Lilli Zeuner

    2009-01-01

    La intención de este artículo es mostrar algunas de las contradicciones que surgen cuando Margaret Archer, en su teoría de la cultura y la agencia, utiliza los análisis de la cultura de Weber y Durkheim como ejemplos de morfogénesis cultural. Además, se intenta explorar acerca de cuáles principios, para la elaboración de una teoría sociológica de la cultura, pueden ser inferidos de estas obras clásicas. Confrontando la teoría de Archer con los análisis de Durkheim y...

  12. Love and Anxiety in the Early Postmodern World of Margaret Atwood’s Dancing Girls

    Directory of Open Access Journals (Sweden)

    Jennifer MURRAY

    2010-09-01

    Full Text Available Cet article se propose d’analyser le recueil de nouvelles Dancing Girls de Margaret Atwood (1977 par le biais de la thématique de l’angoisse ; de la crainte pour soi-même, l’angoisse évolue dans ces nouvelles vers d’autres formes d’angoisse liées à des questions d’éthique et au rapport aux autres. Une lecture minutieuse de plusieurs nouvelles permet de mettre en lumière une logique d’ensemble : l’angoisse qu’explore Atwood est étroitement liée aux relations entre les hommes et femmes à la période des années 60 et 70, où, malgré les promesses de libération sexuelle et féminine, un sentiment latent de vide, ressenti comme l’imminence d’un danger, pouvait être perceptible. Ce ressenti prend forme dans les nouvelles de Dancing Girls à travers des fantasmes de violence ou de victimisation, ainsi que des images associées au gothique et à la figure du double.This article analyses Margaret Atwood’s 1977 short story collection, Dancing Girls, looking at the evolution of forms of anxiety in the different texts, shifting as they do from individual, or self-directed anxiety, to more community-minded, altruistic forms. The article offers a close reading of some of the individual stories, showing how they contribute to an overall logic related (primarily, but not solely to male-female relations in the 1960s and 1970s. In spite of the promises of sexual and self liberation of the period, an underlying sense of emptiness, often experienced as impending danger, is perceptible and takes shape within Atwood’s stories as fantasies of violence or victimization, and appears in figures related to gothic imagery and doubleness.

  13. Sessile serrated polyps of the colorectum are rare in patients with Lynch syndrome and in familial colorectal cancer families

    DEFF Research Database (Denmark)

    Andersen, S H; Lykke, E; Folker, M B

    2008-01-01

    Whereas the generally accepted carcinogenesis pathway of the microsatellite instabile high (MSI-H) colorectal carcinoma (CRC) involves the traditional adenoma in patients with Lynch syndrome, a serrate pathway involving serrate adenomas (SA) and sessile serrate polyps (SSP) characterize the spora......Whereas the generally accepted carcinogenesis pathway of the microsatellite instabile high (MSI-H) colorectal carcinoma (CRC) involves the traditional adenoma in patients with Lynch syndrome, a serrate pathway involving serrate adenomas (SA) and sessile serrate polyps (SSP) characterize...... the FCF, were considered examples of probable SSP. None of the 41 cases coded as adenoma possessed a morphology that qualified as SSP. The prevalence of SSP was not increased as compared to the background population and thus, this serrated lesion does not appear to play a tumorigenic role in Lynch...

  14. Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndrome.

    Science.gov (United States)

    Renkonen-Sinisalo, Laura; Seppälä, Toni T; Järvinen, Heikki J; Mecklin, Jukka-Pekka

    2017-08-01

    The risk of metachronous colorectal cancer is high after surgical resection for first colon cancer in Lynch syndrome. This study aimed to examine whether extended surgery decreases the risk of subsequent colorectal cancer and improves long-term survival. This was a retrospective study. Data were collected from a nationwide registry. Two hundred forty-two Lynch syndrome pathogenic variant carriers who underwent surgery for a first colon cancer from 1984 to 2009 were included. Patients underwent standard segmental colectomy (n = 144) or extended colectomy (n = 98) for colon cancer. Patients were followed a median of 14.6 up to 25 years. Risk of subsequent colorectal cancer in either group, overall and disease-specific survival, and operative mortality were the primary outcomes measured. Subtotal colectomy decreased the risk of subsequent colorectal cancer (HR, 0.20; 95% CI, 0.08-0.52; p = 0.001), compared with segmental resection. Subsequent colorectal cancer decreased in MLH1 carriers. The MSH2 carriers showed no statistical difference, possibly because of their small number. Disease-specific and overall survival within 25 years did not differ between the standard and extended surgeries (82.7% vs 87.2%, p = 0.76 and 47.2% vs 41.4%, p = 0.83). The cumulative risk of subsequent colorectal cancer was 20% in 10 years and 47% within 25 years after standard resection and 4% and 9% after extended surgery. The cumulative risk of metachronous colorectal cancer was 7% within 25 years after subtotal colectomy with ileosigmoidal anastomosis. One patient died of postoperative septicemia within 30 days after segmental colectomy. Data on surgical procedures were primarily collected retrospectively. Lynch syndrome pathogenic variant carriers may undergo subtotal colectomy to manage first colon cancer and avoid repetitive abdominal surgery and to reduce the remaining bowel to facilitate easier endoscopic surveillance. It provides no survival benefit, compared with segmental colon

  15. Validation of a Self-Concept Scale for Lynch Syndrome in Different Nationalities

    DEFF Research Database (Denmark)

    Petersen, Helle Vendel; Domanska, Katarina; Bendahl, Pär-Ola;

    2011-01-01

    syndrome. We compared the performance of this scale in 591 mutation carriers from Denmark, Sweden and Canada. Principal component analysis identified two sets of linked statements-the first related to feeling different, isolated and labeled, and the second to concern and worry about bowel changes....... The scale performed consistently in the three countries. Minor differences were identified, with guilt about passing on a defective gene and feelings of losing one's privacy being more pronounced among Canadians, whereas Danes more often expressed worries about cancer. Validation of the Lynch syndrome self...

  16. Assessing Genetic Variants of Uncertain Significance: The Example of Lynch Syndrome

    DEFF Research Database (Denmark)

    Rasmussen, Lene Juel; Heinen, Christopher D.

    2014-01-01

    variants of uncertain significance (VUS). This leads to anxiety in carriers and noncarrying relatives alike, as well as to an unnecessary burden to preventive healthcare. The establishment of procedures that enable the diagnostic assessment of VUSs in individuals are discussed and hereditary colorectal...... cancer syndrome, Lynch syndrome, is used as an example. This challenge is addressed by illustrating the importance of combining genetic and functional data in future strategies to assess VUS. The proposed strategies combine clinical genetic, analytical, functional and in silico approaches....

  17. The effectiveness of b-lynch sutures in management of atonic postpartum haemorrhage during caesarean section

    Directory of Open Access Journals (Sweden)

    Nidhi Kalkal

    2016-09-01

    Conclusions: This procedure proves to be a valuable addition for surgical treatment of atonic PPH and great advantage in young patients with restoration of future fertility with the added advantage of lesser time of application, lesser blood loss, lesser blood transfusion, lesser skill required. Thus, B-Lynch suturing can be adopted as a mid-step before resorting to uterine devascularisation or hysterectomy when medical line of management fails. [Int J Reprod Contracept Obstet Gynecol 2016; 5(9.000: 2915-2920

  18. Role of the clinical pathology laboratory in the evaluation of endometrial carcinomas for Lynch syndrome.

    Science.gov (United States)

    Djordjevic, Bojana; Broaddus, Russell R

    2014-05-01

    Molecular diagnostic testing of endometrial carcinomas in the pathology laboratory has recently emerged as a key component of the clinical evaluation of Lynch syndrome in many centers. Testing modalities involve immunohistochemical and PCR-based analyses. This article outlines the routine application of these analyses, provides a practical guide for troubleshooting some of the common technical issues related to their performance, and reviews common pitfalls in their interpretation. Discrepancies between tissue testing and genetic testing results are discussed in the context of the current understanding of endometrial cancer biology. The merits of universal versus targeted tissue testing based on clinical patient history and histological tumor appearance are also addressed.

  19. Achieving behaviour change for detection of Lynch syndrome using the Theoretical Domains Framework Implementation (TDFI) approach: a study protocol.

    Science.gov (United States)

    Taylor, Natalie; Long, Janet C; Debono, Deborah; Williams, Rachel; Salisbury, Elizabeth; O'Neill, Sharron; Eykman, Elizabeth; Braithwaite, Jeffrey; Chin, Melvin

    2016-03-12

    Lynch syndrome is an inherited disorder associated with a range of cancers, and found in 2-5 % of colorectal cancers. Lynch syndrome is diagnosed through a combination of significant family and clinical history and pathology. The definitive diagnostic germline test requires formal patient consent after genetic counselling. If diagnosed early, carriers of Lynch syndrome can undergo increased surveillance for cancers, which in turn can prevent late stage cancers, optimise treatment and decrease mortality for themselves and their relatives. However, over the past decade, international studies have reported that only a small proportion of individuals with suspected Lynch syndrome were referred for genetic consultation and possible genetic testing. The aim of this project is to use behaviour change theory and implementation science approaches to increase the number and speed of healthcare professional referrals of colorectal cancer patients with a high-likelihood risk of Lynch syndrome to appropriate genetic counselling services. The six-step Theoretical Domains Framework Implementation (TDFI) approach will be used at two large, metropolitan hospitals treating colorectal cancer patients. Steps are: 1) form local multidisciplinary teams to map current referral processes; 2) identify target behaviours that may lead to increased referrals using discussion supported by a retrospective audit; 3) identify barriers to those behaviours using the validated Influences on Patient Safety Behaviours Questionnaire and TDFI guided focus groups; 4) co-design interventions to address barriers using focus groups; 5) co-implement interventions; and 6) evaluate intervention impact. Chi square analysis will be used to test the difference in the proportion of high-likelihood risk Lynch syndrome patients being referred for genetic testing before and after intervention implementation. A paired t-test will be used to assess the mean time from the pathology test results to referral for high

  20. Ovarian cancer linked to lynch syndrome typically presents as early-onset, non-serous epithelial tumors

    DEFF Research Database (Denmark)

    Bartuma, Katarina; Bernstein, Inge; Malander, Susanne

    2011-01-01

    OBJECTIVE: Heredity is a major cause of ovarian cancer and during recent years the contribution from germline mismatch repair (MMR) gene mutations linked to Lynch syndrome has gradually been recognized. METHODS: We characterized clinical features, tumor morphology and mismatch repair defects in all....... The underlying MMR gene mutations in these families affected MSH2 in 49%, MSH6 in 33% and MLH1 in 17%. Immunohistochemical loss of the corresponding MMR protein was demonstrated in 33/36 (92%) tumors analyzed. CONCLUSION: The combined data from our cohorts demonstrate that ovarian cancer associated with Lynch...

  1. Clinical problems of colorectal cancer and endometrial cancer cases with unknown cause of tumor mismatch repair deficiency (suspected Lynch syndrome

    Directory of Open Access Journals (Sweden)

    Buchanan DD

    2014-10-01

    Full Text Available Daniel D Buchanan,1,2 Christophe Rosty,1,3,4 Mark Clendenning,1 Amanda B Spurdle,5 Aung Ko Win2 1Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, VIC, Australia; 2Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia; 3Envoi Specialist Pathologists, Herston, QLD, Australia; 4School of Medicine, University of Queensland, Herston, QLD, Australia; 5Molecular Cancer Epidemiology Laboratory, Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Herston, QLD, AustraliaAbstract: Carriers of a germline mutation in one of the DNA mismatch repair (MMR genes have a high risk of developing numerous different cancers, predominantly colorectal cancer and endometrial cancer (known as Lynch syndrome. MMR gene mutation carriers develop tumors with MMR deficiency identified by tumor microsatellite instability or immunohistochemical loss of MMR protein expression. Tumor MMR deficiency is used to identify individuals most likely to carry an MMR gene mutation. However, MMR deficiency can also result from somatic inactivation, most commonly methylation of the MLH1 gene promoter. As tumor MMR testing of all incident colorectal and endometrial cancers (universal screening is becoming increasingly adopted, a growing clinical problem is emerging for individuals who have tumors that show MMR deficiency who are subsequently found not to carry an MMR gene mutation after genetic testing using the current diagnostic approaches (Sanger sequencing and multiplex ligation-dependent probe amplification and who also show no evidence of MLH1 methylation. The inability to determine the underlying cause of tumor MMR deficiency in these "Lynch-like" or "suspected Lynch syndrome" cases has significant implications on the clinical management of these individuals and their relatives. When the

  2. Evaluation of Lynch syndrome modifier genes in 748 MMR mutation carriers.

    Science.gov (United States)

    Houlle, Solene; Charbonnier, Françoise; Houivet, Estelle; Tinat, Julie; Buisine, Marie-Pierre; Caron, Olivier; Benichou, Jacques; Baert-Desurmont, Stéphanie; Frebourg, Thierry

    2011-08-01

    Several studies have reported that, in Lynch syndrome resulting from mutations of the mismatch repair (MMR) genes, a CA repeat ≤17 within the IGF1 promoter, SNPs within the xenobiotic metabolizing enzyme gene CYP1A1 and SNPs on 8q23.3 and 11q23.1 modify colorectal cancer (CRC) risk in MMR mutation carriers. We analysed the impact of these polymorphisms on CRC risk in 748 French MMR mutation carriers derived from 359 families. We also analysed the effect of the Novel 1 SNP (18q21), which has recently been shown to increase CRC risk in the general population. We observed a significant difference in the CRC-free survival time between males and females, between MSH2 and MSH6 mutation carriers and between MLH1 and MSH6, indicating that this series is representative of Lynch syndrome. In contrast, the univariate log-rank test, as well as multivariate Cox model analysis controlling for familial aggregation and mutated MMR gene, year of birth and gender showed that the polymorphic alleles tested were not associated with a significant CRC risk increase, neither on the entire sample nor among males and females. This discrepancy with previous reports might be explained both by the genetic heterogeneity between the different populations analysed and the allelic heterogeneity of the MMR mutations. We conclude that genotyping of these polymorphisms is not useful to evaluate CRC risk in MMR mutation carriers and to optimize their clinical follow-up.

  3. Exclusion mapping of a third HNPCC locus in a large Lynch I kindred

    Energy Technology Data Exchange (ETDEWEB)

    Morasse, J.; Khandjian, E.W.; Rousseau, F. [Hopital St-Francois d`Assise, Quebec (Canada)] [and others

    1994-09-01

    Hereditary Non-Polyposis Colorectal Cancer (HNPCC) accounts for 5-10% of all the cases of colorectal cancers. HNPCC can be classified in two clinical forms: (1) Hereditary Site-Specific Colorectal Cancer (HSSCC or Lynch I) and (2) colon cancer associated with extracolonic cancers (Lynch II). Segregation analyses show an autosomal dominant mode of inheritance. In order to identify the HNPCC gene involved in a large Canadian kindred, we performed linkage analysis using microsatellites spanning 9 candidate regions. For all loci tested, the lod score data obtained were negative. Our results demonstrate that the genes hMSH1 and hMLH1 recently reported in HNPCC are not linked in this family. Five loci frequently altered in colorectal tumor cells, APC, MCC, K-ras, p53 and DCC and the DRA gene whose expression is confined to the colon mucosa cells and deregulated in colonic adenomas, are also unlinked to HNPCC susceptibility in this family. We have also excluded chromosomes 4, 5, 8, 11 and 17 as containing the cancer predisposition gene in this family.

  4. Prevalence of somatic mutl homolog 1 promoter hypermethylation in Lynch syndrome colorectal cancer.

    Science.gov (United States)

    Moreira, Leticia; Muñoz, Jenifer; Cuatrecasas, Míriam; Quintanilla, Isabel; Leoz, Maria Liz; Carballal, Sabela; Ocaña, Teresa; López-Cerón, María; Pellise, Maria; Castellví-Bel, Sergi; Jover, Rodrigo; Andreu, Montserrat; Carracedo, Angel; Xicola, Rosa Maria; Llor, Xavier; Boland, Clement Richard; Goel, Ajay; Castells, Antoni; Balaguer, Francesc

    2015-05-01

    Colorectal cancers (CRCs) that have microsatellite instability (MSI) and mutL homolog 1 (MLH1) immunoloss are observed in 3 clinical scenarios: Lynch syndrome (LS), sporadic MSI CRC, and Lynch-like syndrome (LLS). v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) mutational analysis is used to differentiate LS from sporadic MSI CRC. The role of MLH1 promoter methylation status for the differential diagnosis of these clinical forms is not well established. The objectives of this study were: 1) to analyze MLH1 promoter methylation in MLH1-deficient CRCs by pyrosequencing, and 2) to assess its role in the differential diagnosis of MLH1-deficient CRCs. In total, 165 CRCs were analyzed, including LS (n = 19), MSI BRAF-mutated CRC (n = 37), MSI BRAF wild-type CRC (n = 60), and a control group of CRCs without MSI (microsatellite stable [MSS] CRC; n = 49). MLH1 promoter methylation status was analyzed by pyrosequencing, and the ability of different strategies to identify LS was assessed. The average ± standard deviation methylation in LS (9% ± 7%) was significantly lower than that in MSI BRAF-mutated CRC (42% ± 17%; P Cancer Society.

  5. The Use of Social Media to Recruit Participants With Rare Conditions: Lynch Syndrome as an Example.

    Science.gov (United States)

    Burton-Chase, Allison M; Parker, Wendy M; Hennig, Kelsey; Sisson, Faith; Bruzzone, Linda L

    2017-01-23

    Social media is increasingly being used as a means of recruiting participants, particularly for investigators whose areas of interest involve rare conditions or hard-to-reach populations. However, much of the literature to date has focused on paid advertisement recruitment. We used Lynch syndrome (LS), a rare hereditary cancer syndrome, as a model to demonstrate the successful partnership between researchers and a Web-based patient education and advocacy organization to facilitate participant recruitment. Recruitment was undertaken in partnership with Lynch Syndrome International (LSI), an advocacy organization with a strong social media presence. After LSI published our study information, participants followed up via email or phone call. Following prescreening and consent, interested and eligible participants were then sent a secure survey link. Within 36 hours of a single Facebook post by the site administrators for LSI, over 150 individuals responded via phone or email. Sixty-five individuals were sent the survey link and 57 individuals completed the survey (88% response rate). Of note, these 57 individuals were geographically diverse within the Unites States, representing LS patients from 26 different states. This approach has several advantages, including recruitment through a trusted source outside of a clinical setting, higher response rates, and cost-effectiveness with a small research team in a relatively short amount of time. Overall, social media recruitment with a trusted online partner can be highly effective in hard-to-reach clinical populations, such as patients with LS. However, this approach requires additional effort for eligibility screening.

  6. An {sup 57}Fe Mössbauer study of the ordinary chondrite meteorite Lynch 001

    Energy Technology Data Exchange (ETDEWEB)

    Elewa, Nancy N., E-mail: nancy.elewa@student.unsw.edu.au; Cadogan, J. M. [The University of New South Wales at the Australian Defence Force Academy, School of Physical, Environmental and Mathematical Sciences (Australia)

    2017-11-15

    The Lynch 001 meteorite was found in the Nullarbor Plain region of Western Australia in 1977. This meteorite is classified as an ordinary chondrite of the petrologic group L5/6 that has undergone ‘minor to moderate’ terrestrial weathering. Here, we characterize the Fe-bearing phases in this chondrite using {sup 57}Fe Mössbauer spectroscopy carried out over the temperature range 13 K to room temperature (295 K). The paramagnetic doublets of olivine, pyroxene and a superparamagnetic ferric phase dominate the room temperature Mössbauer spectrum. On the basis of the room temperature quadrupole splitting of the olivine component, we estimate its composition to be Fa {sub 30(5)}. Besides the paramagnetic ferric component, accounting for ∼15 % of the spectral area at room temperature, magnetically ordered ferric phases were also detected. The total relative proportion of the Fe {sup 3+} components allows us to estimate the terrestrial age of Lynch 001 to be 6,500 ± 1,500 yr, consistent with the value of 6,700 ± 1,300 yr determined by {sup 14}C dating.

  7. Margaret Thatcherová -- ideologický liberál či reformní pragmatik?

    OpenAIRE

    Segeťová, Marcela

    2009-01-01

    The subject of my thesis is research whether Margaret Thatcher was more liberal or pragmatic in her views along with pursuance of her politics. The thesis is focused on analysing economical-political conditions preceding the election of Mrs. Thatcher as Prime Minister of Great Britain. It also concerns the way Mrs. Thatcher reformed trade-union organizations, public sector, system of taxation, and shows how she managed to encompass privatization within the context of their liberal or pragmati...

  8. A clinical scoring system to identify patients with sebaceous neoplasms at risk for the Muir-Torre variant of Lynch syndrome.

    Science.gov (United States)

    Roberts, Maegan E; Riegert-Johnson, Douglas L; Thomas, Brittany C; Rumilla, Kandelaria M; Thomas, Colleen S; Heckman, Michael G; Purcell, Jennifer U; Hanson, Nancy B; Leppig, Kathleen A; Lim, Justin; Cappel, Mark A

    2014-09-01

    The Muir-Torre syndrome variant of Lynch syndrome is characterized by the presence of sebaceous neoplasms (adenoma, epithelioma/sebaceoma, carcinoma) and Lynch syndrome-associated cancers (colon, endometrial, and others). Several clinical scoring systems have been developed to identify patients with colon cancer at high risk of Lynch syndrome. However, no such system has been described for patients presenting with sebaceous neoplasms. Based on logistic regression analysis, a scoring system was developed for patients with sebaceous neoplasm to identify those with the highest likelihood of having Muir-Torre syndrome. The final version of the scoring system included variables such as age at presentation of initial sebaceous neoplasm, total number of sebaceous neoplasms, personal history of a Lynch-related cancer, and family history of Lynch-related cancers. Patients with a score of 3 or more were more likely to have Muir-Torre syndrome (28 of 29 patients), those with a score of 2 had intermediate likelihood (12 of 20 patients), and no patient with a score of 0 or 1 was diagnosed with Muir-Torre syndrome. The Mayo Muir-Torre syndrome risk scoring system appears to identify whether patients who present with sebaceous neoplasms are in need of further Lynch syndrome evaluation using easily ascertained clinical information. Abnormal mismatch repair gene immunohistochemistry of a sebaceous neoplasm is a poor predictor in regard to diagnosing Lynch syndrome.

  9. Limited impact on self-concept in individuals with Lynch syndrome; results from a national cohort study

    DEFF Research Database (Denmark)

    Petersen, Helle Vendel; Esplen, Mary Jane; Ladelund, Steen;

    2011-01-01

    An increasing number of individuals seek genetic counseling and hereby learn about hereditary cancer in the family. Lynch syndrome is associated with an inherited high risk for colorectal and gynecological cancer, but knowledge about how family members at risk perceive their situation is limited...

  10. Analysis of Families with Lynch Syndrome Complicated by Advanced Serrated Neoplasia: The Importance of Pathology Review and Pedigree Analysis

    Science.gov (United States)

    Walsh, Michael D; Buchanan, Daniel D; Walters, Rhiannon; Roberts, Aedan; Arnold, Sven; McKeone, Diane; Clendenning, Mark; Ruszkiewicz, Andrew R; Jenkins, Mark A; Hopper, John L; Goldblatt, Jack; George, Jillian; Suthers, Graeme K; Phillips, Kerry; Young, Graeme P; Macrae, Finlay; Drini, Musa; Woods, Michael O; Parry, Susan; Jass, Jeremy R; Young, Joanne P

    2009-01-01

    The identification of Lynch syndrome has been greatly assisted by the advent of tumour immunohistochemistry (IHC) for mismatch repair (MMR) proteins, and by the recognition of the role of acquired somatic BRAF mutation in sporadic MMR-deficient colorectal cancer (CRC). However, somatic BRAF mutation may also be present in the tumours in families with a predisposition to develop serrated polyps in the colorectum. In a subgroup of affected members in these families, CRCs emerge which demonstrate clear evidence of MMR deficiency with absent MLH1 staining and high-level microsatellite instability (MSI). This may result in these families being erroneously classified as Lynch syndrome or, conversely, an individual is considered “sporadic” due to the presence of a somatic BRAF mutation in a tumour. In this report, we describe two Lynch syndrome families who demonstrated several such inconsistencies. In one family, IHC deficiency of both MSH2 and MLH1 was demonstrated in tumours from different affected family members, presenting a confusing diagnostic picture. In the second family, MLH1 loss was observed in the lesions of both MLH1 mutation carriers and those who showed normal MLH1 germline sequence. Both families had Lynch syndrome complicated by an independently segregating serrated neoplasia phenotype, suggesting that in families such as these, tumour and germline studies of several key members, rather than of a single proband, are indicated to clarify the spectrum of risk. PMID:19241144

  11. Body Mass Index Increases Risk of Colorectal Adenomas in Men With Lynch Syndrome : The GEOLynch Cohort Study

    NARCIS (Netherlands)

    Botma, Akke; Nagengast, Fokko M.; Braem, Marieke G. M.; Hendriks, Jan C. M.; Kleibeuker, Jan H.; Vasen, Hans F. A.; Kampman, Ellen

    2010-01-01

    Purpose High body mass index (BMI) is an established risk factor for sporadic colorectal cancer. Still, the influence of BMI on hereditary colorectal cancer (eg, Lynch syndrome [LS]), is unknown. The objective of this study was to assess whether BMI is associated with colorectal adenoma occurrence

  12. Chromosome 8q23.3 and 11q23.1 Variants Modify Colorectal Cancer Risk in Lynch Syndrome

    NARCIS (Netherlands)

    Wijnen, Juul T.; Brohet, Richard M.; Van Eijk, Ronald; Jagmohan-Changur, Shanty; Middeldorp, Anneke; Tops, Carli M.; Van Puijenbroek, Mario; Ausems, Margreet G. E. M.; Garcia, Encarna Gomez; Hes, Frederik J.; Hoogerbrugge, Nicoline; Menko, Fred H.; Van Os, Theo A. M.; Sijmons, Rolf H.; Verhoef, Senno; Wagner, Anja; Nagengast, Fokko M.; Kleibeuker, Jan H.; Devilee, Peter; Morreau, Hans; Goldgar, David; Tomlinson, Ian P.; Houlston, Richard S.; Van Wezel, Tom; Vasen, Hans F. A.

    2009-01-01

    Background & Aims: Recent genome-wide association studies have identified common low-risk variants for colorectal cancer (CRC). To assess whether these influence CRC risk in the Lynch syndrome, we genotyped these variants in a large series of proven mutation carriers. Methods: We studied 675 individ

  13. Sessile serrated polyps of the colorectum are rare in patients with Lynch syndrome and in familial colorectal cancer families

    DEFF Research Database (Denmark)

    Andersen, S H; Lykke, E; Folker, M B;

    2008-01-01

    (FCF) is addressed. Polyps coded as hyperplastic polyps (HP) from subjects with Lynch syndrome and FCF enrolled in the HNPCC-register at the Hvidovre University Hospital as well as adenomas from this population were retrieved and reviewed for features of SSP. Ninety-eight polyps coded as HP and 41...

  14. Lynch syndrome-associated extracolonic tumors are rare in two extended families with the same EPCAM deletion

    NARCIS (Netherlands)

    Lynch, H.T.; Riegert-Johnson, D.L.; Snyder, C.; Lynch, J.F.; Hagenkord, J.; Boland, C.R.; Rhees, J.; Thibodeau, S.N.; Boardman, L.A.; Davies, J.; Kuiper, R.P.; Hoogerbrugge, N.; Ligtenberg, M.J.L.

    2011-01-01

    OBJECTIVES: The Lynch syndrome (LS) is an inherited cancer syndrome showing a preponderance of colorectal cancer (CRC) in context with endometrial cancer and several other extracolonic cancers, which is due to pathogenic mutations in the mismatch repair (MMR) genes, MLH1, MSH2, MSH6, and PMS2. Some

  15. Barriers and Motivators for Referral of Patients with Suspected Lynch Syndrome to Cancer Genetic Services: A Qualitative Study

    Directory of Open Access Journals (Sweden)

    Yen Y. Tan

    2014-02-01

    Full Text Available This article explores the views of general practitioners and specialists on their referral of patients with suspected Lynch syndrome to cancer genetic services. Using a purposive maximum variation sampling strategy, we conducted semi-structured interviews face-to-face with 28 general practitioners and specialists in public or private hospitals and specialist clinics between March and August 2011. General practitioners and specialists were recruited in a major metropolitan area in Australia. Interview transcripts were reviewed by two independent researchers, and thematic analysis was performed using NVivo10 software. The main barriers and motivators identified were: (1 clinician-related (e.g., familiarity with Lynch syndrome and family history knowledge; (2 patient-related (e.g., patients’ interests and personal experience with cancer; and (3 organizational-related (e.g., access to services, guidelines and referral pathway. Referral of patients with suspected Lynch syndrome to cancer genetic services is motivated and hindered by a range of individual, interpersonal and organizational factors. In order to improve the care and quality of life of patients and family with suspected Lynch syndrome, further research is needed to develop supportive tools for clinicians.

  16. Out of Amazonia: the unexpected trans-Andean distribution of Cochranella resplendens (Lynch and Duellman, 1978) (Anura: Centrolenidae).

    Science.gov (United States)

    Molina-Zuluaga, Claudia; Cano, Estefany; Restrepo, Adriana; Rada, Marco; Daza, Juan M

    2017-03-02

    The glassfrog genus Cochranella, with nine recognized species, is distributed in the lowlands and mid elevation of the Neotropical forests, from Nicaragua to Bolivia (Guayasamin et al. 2009; Twomey et al. 2014). Four species are trans-Andean-C. granulosa (Taylor 1949) occurs in the lowlands and mountains, at mid elevation, of Central America, C. litoralis (Ruiz-Carranza & Lynch 1996) and C. mache Guayasamin & Bonaccorso 2004 occur in the Pacific lowlands and the western cloud forests of Colombia and Ecuador, and C. euknemos (Savage & Starrett 1967) occurs both in Central America and South America (northwestern Colombia).-The other five species have cis-Andean distributions in the Amazonian slopes and lowlands, from Colombia to Bolivia: C. nola Harvey 1996, C. guayasamini Twomey, Delia & Castroviejo-Fisher 2014, C. resplendens (Lynch & Duellman 1973), C. erminea Torres-Gastello, Suárez-Segovia & Cisneros-Heredia 2007, and C. phryxa Aguayo-Vedia & Harvey 2006. In Colombia, C. resplendens is known from the foothills of the Amazon versant in Caquetá (Malambo et al. 2013) and Putumayo (Lynch & Duellman 1973; Ruiz-Carranza et al. 1996). The species is also known from Ecuador (Lynch & Duellman 1973) and Peru (Twomey et al. 2014). Here, we report two new records of Cochranella resplendens, extending the species distribution beyond the Amazonian lowlands into the northern Cordillera Central in Colombia.

  17. Rectal Cancer Diagnosed after Cesarean Section in Which High Microsatellite Instability Indicated the Presence of Lynch Syndrome

    Directory of Open Access Journals (Sweden)

    Tomohiro Okuda

    2015-01-01

    Full Text Available We report a case of rectal cancer with microsatellite instability (MSI that probably resulted from Lynch syndrome and that was diagnosed after Cesarean section. The patient was a 28-year-old woman (gravid 1, para 1 without a significant medical history. At 35 gestational weeks, vaginal ultrasonography revealed a 5 cm tumor behind the uterine cervix, which was diagnosed as a uterine myoma. The tumor gradually increased in size and blocked the birth canal, resulting in the patient undergoing an emergency Cesarean section. Postoperatively, the tumor was diagnosed as rectal cancer with MSI. After concurrent chemoradiation therapy, a lower anterior resection was performed. The patient’s family history revealed she met the criteria of the revised Bethesda guidelines for testing the colorectal tumor for MSI. Testing revealed that the tumor did indeed show high MSI and, combined with the family history, suggested this could be a case of Lynch syndrome. Our findings emphasize the importance of considering the possibility of Lynch syndrome in pregnant women with colorectal cancer, particularly those with a family history of this condition. We suggest that the presence of Lynch syndrome should also be considered for any young woman with endometrial, ovarian, or colorectal cancer.

  18. Revised guidelines for the clinical management of Lynch syndrome (HNPCC) : Recommendations by a group of European experts

    NARCIS (Netherlands)

    Vasen, Hans F. A.; Blanco, Ignacio; Aktan-Collan, Katja; Gopie, Jessica P.; Alonso, Angel; Aretz, Stefan; Bernstein, Inge; Bertario, Lucio; Burn, John; Capella, Gabriel; Colas, Chrystelle; Engel, Christoph; Frayling, Ian M.; Genuardi, Maurizio; Heinimann, Karl; Hes, Frederik J.; Hodgson, Shirley V.; Karagiannis, John A.; Lalloo, Fiona; Lindblom, Annika; Mecklin, Jukka-Pekka; Moller, Pal; Myrhoj, Torben; Nagengast, Fokko M.; Parc, Yann; de Leon, Maurizio Ponz; Renkonen-Sinisalo, Laura; Sampson, Julian R.; Stormorken, Astrid; Sijmons, Rolf H.; Tejpar, Sabine; Thomas, Huw J. W.; Rahner, Nils; Wijnen, Juul T.; Jaervinen, Heikki Juhani; Moeslein, Gabriela; Jarvinen, H.J.; Moslein, G.

    2013-01-01

    Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. In 2007, a group of European experts (the Mallorca group) published guidelines for th

  19. Qual capacidade crítica? Relendo Luc Boltanski à luz de Margaret Archer

    Directory of Open Access Journals (Sweden)

    Luiz Augusto Campos

    Full Text Available Resumo A chamada “sociologia da capacidade crítica” de Luc Boltanski vem se tornando um dos principais paradigmas teóricos de interpretação das relações sociais. Contrário ao modo como a sociologia crítica à la Bourdieu entende a reflexividade humana, Boltanski propõe tratar os indivíduos como seres reflexivos, plenamente capazes de julgar e criticar o mundo. No entanto, essa “capacidade crítica” funciona em sua sociologia mais como premissa teórica do que como objeto concreto de investigação. Diante disso, este texto argumenta que uma sociologia interessada na capacidade crítica dos sujeitos não pode apenas “supô-la”, deve constituí-la em objeto de estudo sociológico. Para tal, propõe-se reconceituar a capacidade crítica como competência reflexiva, no sentido dado à expressão pela socióloga inglesa Margaret Archer. O recurso às categorias de Archer não apenas ajuda a identificar os limites da sociologia de Boltanski, mas, sobretudo, permite ampliar o seu alcance.

  20. Margaret E. O'Kane on healthcare accreditation. Interview by Wanda Bishop and Kevin C. Park.

    Science.gov (United States)

    O'Kane, M E

    2001-01-01

    Since 1990, Margaret E. O'Kane has served as president of the National Committee for Quality Assurance (NCQA), an independent, not-for-profit organization whose mission is to improve the quality of healthcare everywhere. Under O'Kane's leadership, NCQA has developed broad support among the employer and health plan communities; today many Fortune 100 companies will do business only with NCQA-accredited health plans. About three quarters of the nation's largest employers use Health Plan Employer Data and Information Set (HEDIS) data to evaluate the plans that serve their employees. O'Kane was named Health Person of the Year in 1996 by the journal Medicine & Health. She also received a 1997 Founder's Award from the American College of Medical Quality, recognizing NCQA's efforts to improve managed care quality. In 1999, O'Kane was elected a member of the Institute of Medicine. In 2000, she received the Centers for Disease Control and Prevention (CDC) Champion of Prevention award, the agency's highest honor. CDC names a Champion of Prevention infrequently and only when an individual has made a truly notable contribution to advancing preventive healthcare. O'Kane began her career in healthcare as a respiratory therapist and has a master's degree in health administration and planning from Johns Hopkins University.

  1. Margaret Fulton: A study of a 1960s Australian food writer as an activist

    Directory of Open Access Journals (Sweden)

    Donna Lee Brien

    2011-03-01

    Full Text Available Today, food writing makes up a significant proportion of the texts written, published, sold and read each year in Australia. While the food writing published in magazines and cookbooks has often been thought of as providing useful, but relatively banal, practical skills-based information to its readers, relatively recent reassessments suggest that food writing is much more interesting and important than this. In the contemporary context, when the mere mention of food engenders considerable anxiety, food writers play a number of roles beyond providing information on how to buy, store, prepare and serve various provisions. Instead, contemporary food writers engage with a range of important issues around food production and consumption including sustainable and ethical agriculture, biodiversity and genetic modification, food miles and fair trade, food safety and security, and obesity, diabetes and other health issues. In this, Australian food writers not only provide comment on any important issues in progress, they are also, I suggest, forward-thinking activists, advocating and campaigning for change. This paper focuses on prominent Australian food writer Margaret Fulton’s career in the 1960s to begin to investigate her work as an activist: that is, one who advocates and campaigns to bring about change.

  2. De l'antropologia a l'educació. Una lectura des de Margaret Mead

    Directory of Open Access Journals (Sweden)

    Eulàlia Collelldemont Pujadas

    2006-01-01

    Full Text Available En el presente artículo se ensaya una aproximación a la obra de la antropóloga Margaret Mead en clave pedagógica. Siendo así que se muestra una interpretación sobre sus pensamientos alrededor de la educación a partir de los estudios, comentarios y opiniones sobre los sistemas educativos, relaciones educativas y procesos de enseñanza aprendizaje que se explicitan, reiteradamente, a lo largo de su obra. A fin de cuentas, y como la propia autora indicaba, estudiar la educación era implícitamente necesario a todo estudio antropológico. Concepción que la llevó a incluir en la mayor parte de sus estudios, variables de análisis educativos, llegando incluso a centralizar la atención en este ámbito como idea central de algunos de sus escritos. Añadir además que, en esta síntesis se ha optado por presentar la evolución de su pensamiento pedagógico en base a momentos singulares y carismáticos, mostrando así las distintas continuidades y discontinuidades de su pensamiento. _____________________________________________________________________________________________________________________________________________________________________________ La présente étude tente une approche de l’oeuvre de l’anthropologue Margaret Mead dans une perspective pédagogique. C’est ainsi qu’est présentée une interprétation sur ses réflexions autour de l’éducation à partir des études, commentaires et opinions sur les systèmes éducatifs, des relations éducatives et des processus d’enseignementapprentissage qui sont explicités, de manière réitérée, tout au long de son oeuvre. En fin de compte, et comme l’auteur elle-même l’indiquait, étudier l’éducation était implicitement nécessaire à toute étude anthropologique. C’est une conception qui l’entraîna d’ailleurs à inclure dans la plupart de ses études des variables d’analyses éducatives, en parvenant même à centrer l’attention sur ce domaine comme id

  3. The Robber Bride: a Dystopian Female World in Margaret Atwood’s Mythology

    Directory of Open Access Journals (Sweden)

    Maja Ćuk

    2015-06-01

    Full Text Available The aim of this paper is to show how Atwood’s reformulations of myths contain hidden political messages from ancient and modern history and can be interpreted from Fredric Jameson’s views on ‘symbolic acts,’ discourse and the ideology of form. Several scholars have explored the symbolic relationship between the three major protagonists in The Robber Bride and fragments of the omnipotent image of the Neolithic deity the White Goddess. As the symbolic counterparts of Diana, Venus and Hecate in the novel, Tony, Roz and Charis demonstrate how women’s integrity has been crippled and how the restoration of female principle is just a utopian idea. However, our analysis has revealed that the younger generation of “goddesses” does not bring hope to the female gender in either the present or the future. Augusta, Paula and Erin symbolize oversimplified and parodied versions of the destructive Hecate in an unpromising world and “the not-good place” that resembles a dystopia. Keywords: Margaret Atwood, The Robber Bride, the White Goddess, a dystopian world, Hecate, Fredric Jameson

  4. Adopting a blended approach to learning: Experiences from Radiography at Queen Margaret University, Edinburgh

    Energy Technology Data Exchange (ETDEWEB)

    Cockbain, M.M. [Radiography, School of Health Sciences, Queen Margaret University, Queen Margaret University Drive, Musselburgh, Edinburgh EH21 6UU (United Kingdom)], E-mail: mcockbain@qmu.ac.uk; Blyth, C.M. [Radiography, School of Health Sciences, Queen Margaret University, Queen Margaret University Drive, Musselburgh, Edinburgh EH21 6UU (United Kingdom); Bovill, C. [Edinburgh and Teaching and Learning Service, University of Glasgow, Glasgow (United Kingdom); Morss, K. [Centre for Academic Practice, Queen Margaret University (United Kingdom)

    2009-08-15

    The perspective of the radiography teaching team at Queen Margaret University (QMU) was that a transmission mode of programme delivery was sub-optimal in helping students to learn and make links between theory and practice. Programme redesign adopted a blended learning approach with both face-to-face and online learning aimed at enhancing the students' control over their own learning. Online tasks within Web Classroom Tools (WebCT) were used as an integral part of careful programme design, which resulted in a programme enabling synthesis of the skills, knowledge and competencies acquired in the academic and clinical environments. With the move towards a more learner-centred, blended educational experience for the students the lecturers' role shifted to that of facilitator with WebCT providing the tutor with a more transparent view of student learning. Lecturers plan learning activities that build upon the skills students have developed through learning in groups, online and in class. The explicit connections that now exist between the academic programme and the opportunities for applying knowledge in practice allow students to engage more deeply in their learning.

  5. Differential expression of CK20, β-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X

    DEFF Research Database (Denmark)

    Haraldsson, Stefan; Klarskov, Louise; Nilbert, Mef

    2017-01-01

    BACKGROUND: Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other...... than MMR proteins. METHODS: We compared the expression patterns of cytokeratins (CK7 and CK20), mucins (MUC2/5 AC/6), CDX2 and β-catenin in Lynch syndrome and FCCTX. RESULTS: Differences were identified for CK20 and nuclear β-catenin, which were significantly more often expressed in FCCTX than in Lynch...

  6. Lynching Luther

    DEFF Research Database (Denmark)

    Backe, Hans-Joachim

    2016-01-01

    police procedurals. The character of DCI John Luther is indicative of the series’ general approach: he is unmistakably constructed from stereotypes of US television, yet not in a straightforward way, as he combines elements of both the impulsive, physical maverick cop and the psychologically adept......, cerebral detective – two character-types traditionally rather juxtaposed as irreconcilable opposites. In this fashion, the overall story arc meshes together elements from Thomas Harris-style serial killer fiction and intuitive detection in the tradition of George Simenon’s Maigret. Similarly...... as the id to his superior Rose Teller’s super-ego and his former partner Ian Reed’s ego, a configuration his subconscious tries to overwrite by juxtaposing those two characters to sociopath Alice Morgan and sophomore detective Justin Ripley. The second season finds Luther at odds with several mother figures...

  7. Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Hong; Zeng, Hong; Lam, Robert; Tempel, Wolfram [University of Toronto, 101 College Street, Toronto, ON M5G 1L7 (Canada); Kerr, Iain D., E-mail: ikerr@myriad.com [Myriad Genetic Laboratories Inc., 320 Wakara Way, Salt Lake City, UT 84108 (United States); Min, Jinrong, E-mail: ikerr@myriad.com [University of Toronto, 101 College Street, Toronto, ON M5G 1L7 (Canada); University of Toronto, Toronto, ON M5G 1L7 (Canada)

    2015-07-28

    The crystal structure of the human MLH1 N-terminus is reported at 2.30 Å resolution. The overall structure is described along with an analysis of two clinically important mutations. Mismatch repair prevents the accumulation of erroneous insertions/deletions and non-Watson–Crick base pairs in the genome. Pathogenic mutations in the MLH1 gene are associated with a predisposition to Lynch and Turcot’s syndromes. Although genetic testing for these mutations is available, robust classification of variants requires strong clinical and functional support. Here, the first structure of the N-terminus of human MLH1, determined by X-ray crystallography, is described. The structure shares a high degree of similarity with previously determined prokaryotic MLH1 homologs; however, this structure affords a more accurate platform for the classification of MLH1 variants.

  8. Bayesian Modeling for Genetic Anticipation in Presence of Mutational Heterogeneity: A Case Study in Lynch Syndrome

    DEFF Research Database (Denmark)

    Boonstra, Philip S; Mukherjee, Bhramar; Taylor, Jeremy M G;

    2011-01-01

    inferential conclusions. We compare the fit of four-candidate random effects distributions via Bayesian model fit diagnostics. A related statistical issue here is isolating the confounding effect of changes in secular trends, screening, and medical practices that may affect time to disease detection across...... to cause hereditary nonpolyposis colorectal cancer, also called Lynch syndrome (LS). We find evidence for a decrease in AOO between generations in this article. Our model predicts family-level anticipation effects that are potentially useful in genetic counseling clinics for high-risk families....... birth cohorts. Using historic cancer registry data, we borrow from relative survival analysis methods to adjust for changes in age-specific incidence across birth cohorts. Our motivating case study comes from a Danish cancer register of 124 families with mutations in mismatch repair (MMR) genes known...

  9. Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations

    DEFF Research Database (Denmark)

    Nielsen, Sofie V,; Stein, Amelie; Dinitzen, Alexander B.

    2017-01-01

    Accurate methods to assess the pathogenicity of mutations are needed to fully leverage the possibilities of genome sequencing in diagnosis. Current data-driven and bioinformatics approaches are, however, limited by the large number of new variations found in each newly sequenced genome, and often...... and for diagnosis of Lynch syndrome, and perhaps other hereditary diseases.......Accurate methods to assess the pathogenicity of mutations are needed to fully leverage the possibilities of genome sequencing in diagnosis. Current data-driven and bioinformatics approaches are, however, limited by the large number of new variations found in each newly sequenced genome, and often...... do not provide direct mechanistic insight. Here we demonstrate, for the first time, that saturation mutagenesis, biophysical modeling and co-variation analysis, performed in silico, can predict the abundance, metabolic stability, and function of proteins inside living cells. As a model system, we...

  10. Molecular testing in colorectal cancer: diagnosis of Lynch syndrome and personalized cancer medicine.

    Science.gov (United States)

    Shi, Chanjuan; Washington, Kay

    2012-06-01

    Currently, molecular testing in colorectal cancer (CRC) is aimed at detecting Lynch syndrome and predicting response to anti-epidermal growth factor receptor (EGFR) therapies. However, CRC is a complex disease, with at least 3 molecular pathways of carcinogenesis. The importance of the EGFR signaling pathway in colorectal carcinogenesis is underscored by the availability of anti-EGFR monoclonal antibodies for the treatment of some metastatic CRCs. Potentially, mutations in any of the genes in the EGFR signaling pathway may be associated with prognosis and may predict response to anti-EGFR or other targeted therapies. Although not currently the standard of care, molecular testing of CRCs is expanding to include mutational analysis of the genes in the EGFR pathway, in addition to more widely performed tests for identifying cancers with high microsatellite instability. Multiplex molecular prognostic panels for therapeutic decision making in stage II CRCs also represent expanding use of molecular testing for this common cancer.

  11. The Use of Social Media to Recruit Participants With Rare Conditions: Lynch Syndrome as an Example

    Science.gov (United States)

    Parker, Wendy M; Hennig, Kelsey; Sisson, Faith; Bruzzone, Linda L

    2017-01-01

    Background Social media is increasingly being used as a means of recruiting participants, particularly for investigators whose areas of interest involve rare conditions or hard-to-reach populations. However, much of the literature to date has focused on paid advertisement recruitment. Objective We used Lynch syndrome (LS), a rare hereditary cancer syndrome, as a model to demonstrate the successful partnership between researchers and a Web-based patient education and advocacy organization to facilitate participant recruitment. Methods Recruitment was undertaken in partnership with Lynch Syndrome International (LSI), an advocacy organization with a strong social media presence. After LSI published our study information, participants followed up via email or phone call. Following prescreening and consent, interested and eligible participants were then sent a secure survey link. Results Within 36 hours of a single Facebook post by the site administrators for LSI, over 150 individuals responded via phone or email. Sixty-five individuals were sent the survey link and 57 individuals completed the survey (88% response rate). Of note, these 57 individuals were geographically diverse within the Unites States, representing LS patients from 26 different states. Conclusions This approach has several advantages, including recruitment through a trusted source outside of a clinical setting, higher response rates, and cost-effectiveness with a small research team in a relatively short amount of time. Overall, social media recruitment with a trusted online partner can be highly effective in hard-to-reach clinical populations, such as patients with LS. However, this approach requires additional effort for eligibility screening. PMID:28115298

  12. Whole Gene Capture Analysis of 15 CRC Susceptibility Genes in Suspected Lynch Syndrome Patients.

    Directory of Open Access Journals (Sweden)

    Anne M L Jansen

    Full Text Available Lynch Syndrome (LS is caused by pathogenic germline variants in one of the mismatch repair (MMR genes. However, up to 60% of MMR-deficient colorectal cancer cases are categorized as suspected Lynch Syndrome (sLS because no pathogenic MMR germline variant can be identified, which leads to difficulties in clinical management. We therefore analyzed the genomic regions of 15 CRC susceptibility genes in leukocyte DNA of 34 unrelated sLS patients and 11 patients with MLH1 hypermethylated tumors with a clear family history.Using targeted next-generation sequencing, we analyzed the entire non-repetitive genomic sequence, including intronic and regulatory sequences, of 15 CRC susceptibility genes. In addition, tumor DNA from 28 sLS patients was analyzed for somatic MMR variants.Of 1979 germline variants found in the leukocyte DNA of 34 sLS patients, one was a pathogenic variant (MLH1 c.1667+1delG. Leukocyte DNA of 11 patients with MLH1 hypermethylated tumors was negative for pathogenic germline variants in the tested CRC susceptibility genes and for germline MLH1 hypermethylation. Somatic DNA analysis of 28 sLS tumors identified eight (29% cases with two pathogenic somatic variants, one with a VUS predicted to pathogenic and LOH, and nine cases (32% with one pathogenic somatic variant (n = 8 or one VUS predicted to be pathogenic (n = 1.This is the first study in sLS patients to include the entire genomic sequence of CRC susceptibility genes. An underlying somatic or germline MMR gene defect was identified in ten of 34 sLS patients (29%. In the remaining sLS patients, the underlying genetic defect explaining the MMRdeficiency in their tumors might be found outside the genomic regions harboring the MMR and other known CRC susceptibility genes.

  13. Germline mutation analysis of MLH1 and MSH2 in Malaysian Lynch syndrome patients

    Institute of Scientific and Technical Information of China (English)

    Mohd Nizam Zahary; Gurjeet Kaur; Muhammad Radzi Abu Hassan; Harjinder Singh; Venkatesh R Naik; Ravindran Ankathil

    2012-01-01

    AIM:To investigate the protein expression profile of mismatch repair (MMR) genes in suspected cases of Lynch syndrome and to characterize the associated germline mutations.METHODS:Immunohistochemical analysis of tumor samples was performed to determine the protein expression profile of MMR protein.Germline mutation screening was carried out on peripheral blood samples.The entire exon regions of MLH1 and MSH2 genes were amplified by polymerase chain reaction,screened by denaturing high performance liquid chromatography (dHPLC) and analyzed by DNA sequencing to characterize the germline mutations.RESULTS:Three out of 34 tissue samples (8.8%) and four out of 34 tissue samples (11.8%) showed loss of nuclear staining by immunohistochemistry,indicating the absence of MLH1 and MSH2 protein expression in carcinoma cells,respectively.dHPLC analysis followed by DNA sequencing showed these samples to have germline mutations of MSH2 gene.However,no deleterious mutations were identified in any of the 19 exons or coding regions of MLH1 gene,but we were able to identify MLH1 promoter polymorphism,-93G >A (rs1800734),in 21 out of 34 patients (61.8%).We identified one novel mutation,transversion mutation c.2005G > C,which resulted in a missense mutation (Gly669Arg),a transversion mutation in exon 1,c.142G > T,which resulted in a nonsense mutation (Glu48Stop)and splice-site mutation,c.2006-6T > C,which was adjacent to exon 13 of MSH2 gene.CONCLUSION:Germline mutations were identified in four Malaysian Lynch syndrome patients.Immunohistochemical analysis of tumor tissue proved to be a good pre-screening test before proceeding to germline mutation analysis of DNA MMR genes.

  14. MARGARET ANDERSON AS AN EDITOR OF «THE LITTLE REVIEW» MAGAZINE

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    A. F. GORBUNENKO

    2016-01-01

    Full Text Available The article generalizes way of relevant segment of media sphere of the first half of 20 cent. “The Little Review” (1914-1929, a literary magazine founded by Margaret Caroline Anderson, which has become a model of “uncompromising” periodicals, provide a forum for writers, artists, musicians, anarchists, radicals, socialists. Inviting to cooperate Jane Heap and Ezra Pound, Anderson created a magazine, featuring a wide range of contemporary and early experimental literature. She edited many verses of M. Moor and some poet experiences of E. Pound. For his influence the magazine got flow of international experimentations inviting J. Barns, Th.S. Elliot, U. Lewis, M. Loy, F. Picabia, D. Richardson, M. Sinclair, G. Stine, W.C. Williams, W.B. Yeats. M. Anderson represented for readers “Ulises” by J. Joyce and showed the best persons of imagism and modernism. “The Little Review” made all for demonstrate 23 art schools from 19 countries. Instead of colloquial tone editing articles of Anderson became the reflection of early period of modernism. She wrote long articles criticized the society. The magazine activity of the editor is connected with literature: M. Anderson leave a trace in modernist prose. She published three autobiographic tomes: “My Thirty Years' War: The Autobiography”, 1930; “The Fiery Fountains: The Autobiography», 1951, and “The Strange Necessity: The Autobiography”, 1962. She also wrote two books: “The Little Review Anthology”, 1953, and “The Unknowable Gurdjieff”, 1962.

  15. "[N]ot subject to our sense” : Margaret Cavendish's fusion of Renaissance science, magic and fairy lore.

    Science.gov (United States)

    Walters, Lisa

    2010-01-01

    This article explores Margaret Cavendish's depictions of alchemy, witchcraft and fairy lore in her scientific treatise Philosophical Letters and in fictional texts from Natures Pictures and Poems and Fancies. Though Cavendish was a dedicated materialist, she appropriates theories of magic from early modern science and folklore into her materialist epistemology. As Cavendish draws upon a fusion of early modern conceptions of magic, she creates a radical theory of matter which not only challenges patriarchy and binary oppositions, but also explores the plurality and mystery that can exist within an infinitely complex material world.

  16. The body we have got, the body we are. About the corporeity in the Margaret Mazzantini’s novel

    OpenAIRE

    Barbara Kornacka

    2009-01-01

    The article titled The body we have got, the body we are. About the corporeity in Margaret Mazzantini’s novel treats the phenomenon of corporeity mentioned in the title in a text of the contemporary Italian writer. There are three main aspects of this problem. First, the language connected with the body (descriptions of the look, statements of the body, physiology, erotic life). The next subject is the relationship body-identity. Finally, there is the sense of smell emphasized in the narratio...

  17. 後期中英語の宗教表現 : Margaret Pastonの書簡を通して

    OpenAIRE

    川上, 雅弘; カワカミ, マサヒロ; Masahiro, KAWAKAMI

    2000-01-01

    "The aim of this paper is to describe some religious expressions in Late Middle English on the basis of our own data from Margaret Paston's letters and papers. Despite extensive and complete texts of Paston Letters edited by Gairdner and Davis, a Paston glossary still has not appeared in print. Classifying the data according to the optative and the non- optative types, we suggest that the optative type should take up the position primarily towards the end of the letter and that it should be e...

  18. Development and validation of an instrument to measure the impact of genetic testing on self-concept in Lynch syndrome

    DEFF Research Database (Denmark)

    Esplen, M J; Stuckless, N; Gallinger, S

    2011-01-01

    with two dimensions identified through factor analysis: stigma/vulnerability and bowel symptom-related anxiety. The scale showed excellent reliability (Cronbach's α = 0.93), good convergent validity by a high correlation with impact of event scale (r(102) = 0.55, p self-esteem scale......Esplen MJ, Stuckless N, Gallinger S, Aronson M, Rothenmund H, Semotiuk K, Stokes J, Way C, Green J, Butler K, Petersen HV, Wong J. Development and validation of an instrument to measure the impact of genetic testing on self-concept in Lynch syndrome. A positive genetic test result may impact...... on a person's self-concept and affect quality of life. The purpose of the study was to develop a self-concept scale to measure such impact for individuals carrying mutations for a heritable colorectal cancer Lynch syndrome (LS). Two distinct phases were involved: Phase 1 generated specific colorectal self...

  19. A de novo germline MLH1 mutation in a Lynch syndrome patient with discordant immunohistochemical and molecular biology test results

    Institute of Scientific and Technical Information of China (English)

    Fabrice Airaud; Sébastien Küry; Isabelle Valo; Ingrid Maury; Dominique Bonneau; Olivier Ingster; Stéphane Bezieau

    2012-01-01

    We describe a patient with a Homo sapiens mutL homolog 1 (MLH1)-associated Lynch syndrome with previous diagnoses of two distinct primary cancers:a sigmoid colon cancer at the age of 39 years,and a right colon cancer at the age of 50 years.The mutation identified in his blood and buccal cells,c.1771delG,p.Asp591Ilefs*25,appears to be a de novo event,as it was not transmitted by either of his parents.This type of de novo event is rare in MLH1 as only three cases have been reported in the literature so far.Furthermore,the discordant results observed between replication error phenotyping and immunohistochemistry highlight the importance of the systematic use of both pre-screening tests in the molecular diagnosis of Lynch syndrome.

  20. Mismatch repair-deficient crypt foci in Lynch syndrome--molecular alterations and association with clinical parameters.

    Directory of Open Access Journals (Sweden)

    Laura Staffa

    Full Text Available Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR genes, most frequently MLH1 and MSH2. Recently, MMR-deficient crypt foci (MMR-DCF have been identified as a novel lesion which occurs at high frequency in the intestinal mucosa from Lynch syndrome mutation carriers, but very rarely progress to cancer. To shed light on molecular alterations and clinical associations of MMR-DCF, we systematically searched the intestinal mucosa from Lynch syndrome patients for MMR-DCF by immunohistochemistry. The identified lesions were characterised for alterations in microsatellite-bearing genes with proven or suspected role in malignant transformation. We demonstrate that the prevalence of MMR-DCF (mean 0.84 MMR-DCF per 1 cm2 mucosa in the colorectum of Lynch syndrome patients was significantly associated with patients' age, but not with patients' gender. No MMR-DCF were detectable in the mucosa of patients with sporadic MSI-H colorectal cancer (n = 12. Microsatellite instability of at least one tested marker was detected in 89% of the MMR-DCF examined, indicating an immediate onset of microsatellite instability after MMR gene inactivation. Coding microsatellite mutations were most frequent in the genes HT001 (ASTE1 with 33%, followed by AIM2 (17% and BAX (10%. Though MMR deficiency alone appears to be insufficient for malignant transformation, it leads to measurable microsatellite instability even in single MMR-deficient crypts. Our data indicate for the first time that the frequency of MMR-DCF increases with patients' age. Similar patterns of coding microsatellite instability in MMR-DCF and MMR-deficient cancers suggest that certain combinations of coding microsatellite mutations, including mutations of the HT001, AIM2 and BAX gene, may contribute to the progression of MMR-deficient lesions into MMR-deficient cancers.

  1. A Subgeneric Classification of the Genus Uranotaenia Lynch Arribalzaga, with a Historical Review and Notes on Other Categories

    Science.gov (United States)

    1972-01-01

    first applied by Lynch Arribalzaga in 1891. It was derived from the Greek and Latin combinations of urano (heaven) and taenia (band or stripe) in...have been seen in the subgenus Urano taenia d Other secondary characters seen in Pseudoficalbia only are conspicuous setae at or near the apical...o o e ANNULATA SERIES Although a few of these characters are found in other Urano- taenia species, the peculiar larval head seta 1-C in the annulata

  2. Family perspectives in lynch syndrome becoming a family at risk, patterns of communication and influence on relations

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    Bartuma Katarina

    2012-05-01

    Full Text Available Abstract Background A growing number of individuals are diagnosed with hereditary cancer. Though increased levels of anxiety and depression have been demonstrated around the time of genetic counselling, most individuals handle life at increased risk well. Data have, however, been collected on individual basis, which led us to focus on family perspectives of hereditary cancer. Methods Lynch syndrome represents a major type of hereditary colorectal and gynaecological cancer. We preformed open-ended interviews with 27 informants from 9 Lynch syndrome families. Inductive content analysis revealed three major themes: transition to a risk family, patterns of communication and influence on family relations and individual roles. Results Family members described how learning about Lynch syndrome shifted focus from daily issues to concerns about cancer. Changes in communication related to difficulties in talking to children about heredity and informing new family members and distant relatives about an increased risk of cancer. Influence on relations was exemplified by family members taking on different roles, e.g. females often being responsible for coordinating information about heredity and providing support. Families in which members had experienced cancer at young age typically informed children soon after learning about heredity and at young age, whereas families with experience of cancer at higher age postponed information and thereby also genetic counselling. Conclusions Three major family perspectives are described in Lynch syndrome families; becoming a risk family, patterns of communication and influence on family relations. Since these issues are central, our findings suggests that such family perspectives should be considered during genetic counselling in order to contribute to information spread, help family members cope with the increased risk, and motivate family members at risk to undergo surveillance.

  3. Contribution of Large Genomic Rearrangements in Italian Lynch Syndrome Patients: Characterization of a Novel Alu-Mediated Deletion

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    Francesca Duraturo

    2013-01-01

    Full Text Available Lynch syndrome is associated with germ-line mutations in the DNA mismatch repair (MMR genes, mainly MLH1 and MSH2. Most of the mutations reported in these genes to date are point mutations, small deletions, and insertions. Large genomic rearrangements in the MMR genes predisposing to Lynch syndrome also occur, but the frequency varies depending on the population studied on average from 5 to 20%. The aim of this study was to examine the contribution of large rearrangements in the MLH1 and MSH2 genes in a well-characterised series of 63 unrelated Southern Italian Lynch syndrome patients who were negative for pathogenic point mutations in the MLH1, MSH2, and MSH6 genes. We identified a large novel deletion in the MSH2 gene, including exon 6 in one of the patients analysed (1.6% frequency. This deletion was confirmed and localised by long-range PCR. The breakpoints of this rearrangement were characterised by sequencing. Further analysis of the breakpoints revealed that this rearrangement was a product of Alu-mediated recombination. Our findings identified a novel Alu-mediated rearrangement within MSH2 gene and showed that large deletions or duplications in MLH1 and MSH2 genes are low-frequency mutational events in Southern Italian patients with an inherited predisposition to colon cancer.

  4. Interval colon cancer in a Lynch syndrome patient under annual colonoscopic surveillance: a case for advanced imaging techniques?

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    Oxentenko Amy S

    2012-05-01

    Full Text Available Abstract Background Lynch syndrome confers increased risk for various malignancies, including colorectal cancer. Colonoscopic surveillance programs have led to reduced incidence of colorectal cancer and reduced mortality from colorectal cancer. Colonoscopy every 1–2 years beginning at age 20–25, or 10 years earlier than the first diagnosis of colorectal cancer in a family, with annual colonoscopy after age 40, is the recommended management for mutation carriers. Screening programs have reduced colon cancer mortality, but interval cancers may occur. Case presentation We describe a 48-year-old woman with Lynch syndrome who was found to have an adenoma with invasive colorectal cancer within one year after a normal colonoscopy. Conclusion Our patient illustrates two current concepts about Lynch syndrome: 1 adenomas are the cancer precursor and 2 such adenomas may be “aggressive,” in the sense that the adenoma progresses more readily and more rapidly to carcinoma in this setting compared to usual colorectal adenomas. Our patient’s resected tumor invaded only into submucosa and all lymph nodes were negative; in that sense, she represents a success for annual colonoscopic surveillance. Still, this case does raise the question of whether advanced imaging techniques are advisable for surveillance colonoscopy in these high-risk patients.

  5. Scientists Look at 2010: Carrying on Margaret Mayall's Legacy of Debunking Pseudoscience

    Science.gov (United States)

    Larsen, Krinstine

    2010-06-01

    In 1941 Margaret Mayall, the future director of the AAVSO, and Harvard colleague Bart Bok authored a critical study of astrology and its impact on society entitled "Scientists Look at Astrology." They chastised the scientific community for thinking the debunking of astrology to be "below the dignity of scientists." In contrast, they opined that it is one of the duties of scientists to "inform the public about the nature and background of a current fad, such as astrology, even though to do so may be unpleasant." Fast-forward 68 years in the future, and the astronomical community now faces a pseudoscientific enemy just as insidious as astrology, yet just as ignored by the general professional and amateur community as astrology had been when Mayall and Bok took up the charge in 1941. The pseudoscience in question is the well-publicized "prediction" that the Mayan calendar will end on December 21, 2012, causing the end of civilization in concert with one of a number of possible astronomical calamities, including (but not limited to) the gravitational pull of the center of the Milky Way (somehow enhanced by an "alignment" with our solar system), the near-approach by a mythical 10th planet (often named Nibiru), large-scale damage to the planet by solar flares larger than those ever recorded, or the shifting of the earth's axis of rotation (often confused with a proposed sudden and catastrophic reversal of the earth's magnetic polarity). As a scientific and educational organization, the AAVSO and its members have a responsibility to follow in Mayall's footsteps, shining the light of reason and knowledge on the dark corners of ignorance which far too often permeate the Internet, radio and television programming, and recent films, most notably 2012. This talk will highlight some of the basic premises of the 2012 hysteria and suggest ways that the AAVSO and its members can use variable stars and the history of the AAVSO to counteract some of the astronomical misinformation

  6. Margaret Mead, Bali e o Atlas do comportamento infantil: apontamentos sobre um estudo fotográfico

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    João Martinho de Mendonça

    2010-12-01

    Full Text Available Este artigo analisa a maneira como Margaret Mead concebeu e utilizou as imagens tomadas por Gregory Bateson em Bali (1936-1939 para desenvolver um estudo, quase dez anos depois, sobre o comportamento infantil balinês. Notam-se as limitações tanto da metodologia adotada por Mead quanto do bias político-ideológico que perpassou esse trabalho realizado durante a Guerra Fria. Tento discutir estas limitações tanto quanto sintetizar possibilidades de abordagem das imagens. Pranchas fotográficas foram selecionadas e reproduzidas para mostrar as diferentes perspectivas de abordagem das fotografias, nos trabalhos balineses e no Atlas do comportamento infantil, produzido pelo doutor Arnold Gesell.This article analyses the manner how Margaret Mead conceived and utilized the pictures taken by Gregory Bateson in Bali (1936-1939 to develop her study, almost ten years later, about the balinese children behavior. There are some limitations in this balinese photographic study caused by methodology adopted, and by the political ideological bias that crossed her research realized during the "cold war" period as well. I try to discuss these limitations and to synthesize the approach's possibilities of the images. Photographic plates are selected and reproduced here to show different perspectives of their use, in Mead's balinese works and in the Atlas of infant behavior produced by the doctor Arnold Gesell.

  7. Syndrome de Lynch: à propos d'un cas et revue de la litterature

    Science.gov (United States)

    Bouguenouch, Laila; Samri, Imane; Belhassan, Khadija; Sayel, Hanane; Abbassi, Meriame; Bennis, Sanae; Benajah, Dafr Allah; Ibrahimi, Adil; Amarti, Afaf; Ouldim, Karim

    2016-01-01

    Le syndrome de Lynch, ou cancer colorectal héréditaire sans polypose ou HNPCC (hereditary non-polyposis colorectal cancer), est la forme la plus fréquente de cancer colorectal héréditaire. Il conduit à une augmentation de la susceptibilité à développer des cancers, au premier rang le cancer colorectal, le cancer de l'endomètre chez les femmes, et dans une moindre mesure, d'autres cancers (ovaire, intestin grêle, estomac, voies excrétrices urinaires et hépatobiliaires). Ainsi, le risque cumulé de développer un cancer colorectal ou de l'endomètre à l’âge de 80 ans s’élève respectivement à 20 et 40%. Ces cancers sont caractérisés par leur contexte d'atteinte familiale, leur survenue à un âge précoce, ainsi que par le développement de cancers métachrones chez un même individu. Ce syndrome se transmet de manière autosomique dominante. Les gènes dont l'altération est associée à l'existence d'un syndrome HNPCC appartiennent à la famille des gènes de réparation des mésappariements de l'ADN (DNA mismatch repair ou MMR): MSH2, MLH1 et MSH6 sont impliqués, par ordre décroissant de fréquence, dans respectivement 35%, 25% et 2% des cas. Une surveillance coloscopique et gynécologique est proposée aux personnes porteuses d'une mutation constitutionnelle du gène MSH2, MLH1 ou MSH6. Nous rapportons une des premières observations marocaines d'un syndrome de Lynch dont la mutation constitutionnelle du gène MLH1 a été identifiée chez un des membres de la famille atteint d'un cancer du côlon. Suite à la demande d'autres sujets sains de la même famille, un diagnostic presymptomatique a été effectué conduisant à une stratégie de surveillance adaptée. A travers notre observation nous illustrons le rôle de l'oncogénétique dans la prise en charge des patients cancéreux et de leurs familles. PMID:27642480

  8. Novel Mutations in MLH1 and MSH2 Genes in Mexican Patients with Lynch Syndrome

    Science.gov (United States)

    Moreno-Ortiz, Jose Miguel; Ayala-Madrigal, María de la Luz; Corona-Rivera, Jorge Román; Maciel-Gutiérrez, Víctor; Franco-Topete, Ramón Antonio; Armendáriz-Borunda, Juan; Pérez-Carbonell, Lucia; Rhees, Jennifer; Gutiérrez-Angulo, Melva

    2016-01-01

    Background. Lynch Syndrome (LS) is characterized by germline mutations in the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2. This syndrome is inherited in an autosomal dominant pattern and is characterized by early onset colorectal cancer (CRC) and extracolonic tumors. The aim of this study was to identify mutations in MMR genes in three Mexican patients with LS. Methods. Immunohistochemical analysis was performed as a prescreening method to identify absent protein expression. PCR, Denaturing High Performance Liquid Chromatography (dHPLC), and Sanger sequencing complemented the analysis. Results. Two samples showed the absence of nuclear staining for MLH1 and one sample showed loss of nuclear staining for MSH2. The mutations found in MLH1 gene were c.2103+1G>C in intron 18 and compound heterozygous mutants c.1852_1854delAAG (p.K618del) and c.1852_1853delinsGC (p.K618A) in exon 16. In the MSH2 gene, we identified mutation c.638dupT (p.L213fs) in exon 3. Conclusions. This is the first report of mutations in MMR genes in Mexican patients with LS and these appear to be novel. PMID:27247567

  9. Novel Mutations in MLH1 and MSH2 Genes in Mexican Patients with Lynch Syndrome

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    Jose Miguel Moreno-Ortiz

    2016-01-01

    Full Text Available Background. Lynch Syndrome (LS is characterized by germline mutations in the DNA mismatch repair (MMR genes MLH1, MSH2, MSH6, and PMS2. This syndrome is inherited in an autosomal dominant pattern and is characterized by early onset colorectal cancer (CRC and extracolonic tumors. The aim of this study was to identify mutations in MMR genes in three Mexican patients with LS. Methods. Immunohistochemical analysis was performed as a prescreening method to identify absent protein expression. PCR, Denaturing High Performance Liquid Chromatography (dHPLC, and Sanger sequencing complemented the analysis. Results. Two samples showed the absence of nuclear staining for MLH1 and one sample showed loss of nuclear staining for MSH2. The mutations found in MLH1 gene were c.2103+1G>C in intron 18 and compound heterozygous mutants c.1852_1854delAAG (p.K618del and c.1852_1853delinsGC (p.K618A in exon 16. In the MSH2 gene, we identified mutation c.638dupT (p.L213fs in exon 3. Conclusions. This is the first report of mutations in MMR genes in Mexican patients with LS and these appear to be novel.

  10. Recognition of Lynch Syndrome Amongst Newly Diagnosed Colorectal Cancers at St. Paul’s Hospital

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    Steven Pi

    2017-01-01

    Full Text Available Background. Lynch Syndrome (LS is the most common cause of inherited colorectal cancer (CRC. In British Columbia, most centres still use clinical criteria (Amsterdam II, Revised Bethesda, or the BC Cancer Agency’s criteria to determine who should undergo further first-line testing in the form of microsatellite instability or immunohistochemistry staining. Given the limitations with this strategy, LS is thought to be underrecognized. Objective. To investigate whether LS is truly underrecognized when compared to the reported prevalence. Methods. A retrospective chart review of all CRC cases diagnosed at St. Paul’s Hospital from 2010 to 2013 was conducted. Results. 246 patients met inclusion criteria. 76% (83/109 with a family history of malignancy were unable to recall the specific malignancy or age of diagnosis. 18% (43/235 were only asked about a history of gastrointestinal related malignancy and 26% (65/246 met at least one of the three criteria but only 21% (13/63 received further investigation. Only 1.6% (4/246 had LS compared to the reported prevalence of 2–5% of all CRC cases. Conclusion. This data supports our hypothesis that LS is underrecognized. Issues at the patient, physician, and systems level need to be evaluated to determine where the limitations preventing appropriate testing are occurring.

  11. Molecular profile of the Lynch Syndrome in the Republic of Macedonia

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    Marija Hiljadnikova-Bajro

    2012-12-01

    Full Text Available The most frequent type of hereditary colorectal cancer, the one occurring in the setting of the Lynch syndrome (LS is considered a phenotypic manifestation of a germline defect in the mismatch repair mechanism i.e. in the MLH1, MSH2, MSH6 or PMS2 gene. Aiming towards establishment of a standardized protocol involving molecular analyses for diagnosis of this syndrome and developing a unique national register of families with hereditary colorectal cancer syndromes in the Republic of Macedonia, we began a prospective study to reveal the genetic defects among Macedonian patients with colorectal cancer (CRC and identifying families with hereditary CRC. A total of 53 patients fulfilling the revised Bethesda criteria for MSI-genetic testing were compared to 350 patients with sporadic CRC. The results reveal significant differences in age at diagnosis (p=0.03, involvement of microsatellite instability (pG nonsense mutation with a possible founder effect in the Macedonian population, the MLH1 ex.3-12 deletion, as well as the c.244A>G mutation, IVS14- 19A>G and IVS4+65A>C changes in MLH1 without confirmed pathological significance. The observed high frequency (87.5% of the Ile219Val (c.655A>G variant in MLH1 among the LS suspects prompts further analyses to evaluate its involvement in the development of hereditary CRC by itself or as a risk modifying factor among the patients from the Republic of Macedonia.

  12. Estimating successive cancer risks in Lynch Syndrome families using a progressive three-state model.

    Science.gov (United States)

    Choi, Yun-Hee; Briollais, Laurent; Green, Jane; Parfrey, Patrick; Kopciuk, Karen

    2014-02-20

    Lynch Syndrome (LS) families harbor mutated mismatch repair genes,which predispose them to specific types of cancer. Because individuals within LS families can experience multiple cancers over their lifetime, we developed a progressive three-state model to estimate the disease risk from a healthy (state 0) to a first cancer (state 1) and then to a second cancer (state 2). Ascertainment correction of the likelihood was made to adjust for complex sampling designs with carrier probabilities for family members with missing genotype information estimated using their family's observed genotype and phenotype information in a one-step expectation-maximization algorithm. A sandwich variance estimator was employed to overcome possible model misspecification. The main objective of this paper is to estimate the disease risk (penetrance) for age at a second cancer after someone has experienced a first cancer that is also associated with a mutated gene. Simulation study results indicate that our approach generally provides unbiased risk estimates and low root mean squared errors across different family study designs, proportions of missing genotypes, and risk heterogeneities. An application to 12 large LS families from Newfoundland demonstrates that the risk for a second cancer was substantial and that the age at a first colorectal cancer significantly impacted the age at any LS subsequent cancer. This study provides new insights for developing more effective management of mutation carriers in LS families by providing more accurate multiple cancer risk estimates.

  13. Bayesian modeling for genetic anticipation in presence of mutational heterogeneity: a case study in Lynch syndrome.

    Science.gov (United States)

    Boonstra, Philip S; Mukherjee, Bhramar; Taylor, Jeremy M G; Nilbert, Mef; Moreno, Victor; Gruber, Stephen B

    2011-12-01

    Genetic anticipation, described by earlier age of onset (AOO) and more aggressive symptoms in successive generations, is a phenomenon noted in certain hereditary diseases. Its extent may vary between families and/or between mutation subtypes known to be associated with the disease phenotype. In this article, we posit a Bayesian approach to infer genetic anticipation under flexible random effects models for censored data that capture the effect of successive generations on AOO. Primary interest lies in the random effects. Misspecifying the distribution of random effects may result in incorrect inferential conclusions. We compare the fit of four-candidate random effects distributions via Bayesian model fit diagnostics. A related statistical issue here is isolating the confounding effect of changes in secular trends, screening, and medical practices that may affect time to disease detection across birth cohorts. Using historic cancer registry data, we borrow from relative survival analysis methods to adjust for changes in age-specific incidence across birth cohorts. Our motivating case study comes from a Danish cancer register of 124 families with mutations in mismatch repair (MMR) genes known to cause hereditary nonpolyposis colorectal cancer, also called Lynch syndrome (LS). We find evidence for a decrease in AOO between generations in this article. Our model predicts family-level anticipation effects that are potentially useful in genetic counseling clinics for high-risk families.

  14. Sit Down with Sabin: Margaret Torn: The Carbon Cycle Like You've Never Seen It (LBNL Summer Lecture Series)

    Energy Technology Data Exchange (ETDEWEB)

    Russell, Sabin; Torn, Margaret

    2011-07-06

    Lawrence Berkeley National Laboratory soil scientist Margaret Torn appears July 6, 2011 on "Sit Down with Sabin," a weekly conversation in which former reporter Sabin Russell chats with Berkeley Lab staff about innovative science. Torn discusses how she travels the world to learn more about soil's huge role in the global carbon cycle. Brought to you by Berkeley Lab Public Affairs.

  15. Premio Nacional de Epilepsia “Margaret Merz de Fandiño”.

    Directory of Open Access Journals (Sweden)

    Gustavo Malagón Londoño

    2009-07-01

    Full Text Available

    Este premio, creado con el objetivo de reconocer a los investigadores colombianos comprometidos en el estudio de lo relacionado con las ciencias epileptológicas, es también una manera de estimular al talento humano estudioso y dedicado a aportar su óptimo esfuerzo intelectual para alivio de un padecimiento que afecta directamente a una numerosa población de compatriotas y con ellos impacta a ocho millones de colombianos si contamos la influencia que sobre las familias ejerce esta patología, identificada en 800 mil personas.

    El Premio, aprobado hace dos años en la Asamblea de socios activos de la Liga Colombiana contra la Epilepsia, es una vez más fruto del esfuerzo y tenacidad del Académico Jaime Fandiño Franky, eminente científico de las neurociencias y apóstol de una de las causas que inciden en la situación de los más necesitados en Colombia.

    La labor iniciada por Fandiño Franky hace ya cuatro décadas en la ciudad de Cartagena, con el ánimo de diagnosticar, investigar, tratar, hacer seguimiento y rehabilitación de las víctimas y su entorno familiar, ha llevado a la más ambiciosa realización científica, docente y asistencial, con el montaje primero de una infraestructura física plasmada en un centro de 13.000 metros cuadrados para enfrentar este problema de salud pública, bastante relegado tradicionalmente, pero merecedor por sus proporciones, de una consideración y manejo especiales, que de no prodigarlos el estamento oficial, lo afronta una organización altruista y generosa con Fandiño Franky y Margaret Merz, su esposa, a la cabeza.

    Con el tiempo su organización fue creciendo no sólo física sino cualitativamente con el empleo de las más modernas tecnologías para diagnóstico y tratamiento hasta convertirse en un centro piloto orgullo de Colombia y pionero en Latinoamérica del manejo integral, iniciado con la identificación del paciente y culminado con la rehabilitaci

  16. Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation.

    Science.gov (United States)

    Snowsill, Tristan; Coelho, Helen; Huxley, Nicola; Jones-Hughes, Tracey; Briscoe, Simon; Frayling, Ian M; Hyde, Chris

    2017-09-01

    Inherited mutations in deoxyribonucleic acid (DNA) mismatch repair (MMR) genes lead to an increased risk of colorectal cancer (CRC), gynaecological cancers and other cancers, known as Lynch syndrome (LS). Risk-reducing interventions can be offered to individuals with known LS-causing mutations. The mutations can be identified by comprehensive testing of the MMR genes, but this would be prohibitively expensive in the general population. Tumour-based tests - microsatellite instability (MSI) and MMR immunohistochemistry (IHC) - are used in CRC patients to identify individuals at high risk of LS for genetic testing. MLH1 (MutL homologue 1) promoter methylation and BRAF V600E testing can be conducted on tumour material to rule out certain sporadic cancers. To investigate whether testing for LS in CRC patients using MSI or IHC (with or without MLH1 promoter methylation testing and BRAF V600E testing) is clinically effective (in terms of identifying Lynch syndrome and improving outcomes for patients) and represents a cost-effective use of NHS resources. Systematic reviews were conducted of the published literature on diagnostic test accuracy studies of MSI and/or IHC testing for LS, end-to-end studies of screening for LS in CRC patients and economic evaluations of screening for LS in CRC patients. A model-based economic evaluation was conducted to extrapolate long-term outcomes from the results of the diagnostic test accuracy review. The model was extended from a model previously developed by the authors. Ten studies were identified that evaluated the diagnostic test accuracy of MSI and/or IHC testing for identifying LS in CRC patients. For MSI testing, sensitivity ranged from 66.7% to 100.0% and specificity ranged from 61.1% to 92.5%. For IHC, sensitivity ranged from 80.8% to 100.0% and specificity ranged from 80.5% to 91.9%. When tumours showing low levels of MSI were treated as a positive result, the sensitivity of MSI testing increased but specificity fell. No end

  17. Phenotypic Heterogeneity by Germline Mismatch Repair Gene Defect in Lynch Syndrome Patients.

    Science.gov (United States)

    Hernâni-Eusébio, Jorge; Barbosa, Elisabete

    2016-10-01

    Introdução: A síndrome de Lynch é a forma hereditária mais comum de cancro colo-rectal, sendo também responsável por cancro do endométrio e de outros tipos. Associa-se a mutações germinativas nos genes de mismatch repair do ADN e a instabilidade de microssatélites. As mutações MLH1 e MSH2 têm um fenótipo de síndrome de Lynch ‘clássico’, sendo o MSH2 mais associado a cancro extra-cólico. Mutações do MSH6 e PMS2 têm um fenótipo atípico. A expressão clínica é heterogénea, existindo uma correlação entre o gene mismatch repair mutado e o padrão fenotípico. Material e Métodos: Análise retrospetiva dos dados clínicos de doentes que cumpriam os critérios de Amesterdão ou que tinha mutações nos genes mismatch repair, entre setembro de 2012 e outubro de 2015. Resultados: Identificámos 28 doentes. Dezassete tinham cancro colo-rectal sendo a localização no cólon direito predominante. Cinco tiveram cancro do endométrio (mediana da idade de diagnóstico – 53), sem qualquer mutação no MSH6. Cinco desenvolveram outros cancros. Todos os casos com mutações mismatch repair estudados tinham instabilidade de microssatélites. Discussão: Na maioria dos casos foi encontrada mutação no MSH2 apesar de o MLH1 ser descrito na literatura como o gene mais frequentemente mutado. Interessa dizer que os doentes com cancro colo-rectal não evidenciam uma tendência para ter muito infiltrado inflamatório. Na maioria dos casos foi realizada colectomia parcial apesar da incidência elevada de lesões síncronas e metácronas associadas. Histerectomia e anexectomia profilática foi realizada em doentes em menopausa/perimenopausa. Conclusão: O registo standardizado dos dados dos doentes poderá levar a um melhor acompanhamento e conhecimento desta síndrome. O uso das Guidelines de Bethesda poderá identificar novos casos que escapam aos critérios de Amesterdão. A pesquisa de instabilidade de microssatélites deve ser feita em muito maior n

  18. Educational and Psychosocial Support Needs in Lynch Syndrome: Implementation and Assessment of an Educational Workshop and Support Group.

    Science.gov (United States)

    Corines, Marina J; Hamilton, Jada G; Glogowski, Emily; Anrig, Chris A; Goldberg, Rachael; Niehaus, Kate; Salo-Mullen, Erin; Harlan, Megan; Sheehan, Margaret R; Trottier, Magan; Ahsraf, Asad; Tran, Christina; Jacobs, Lauren; Rau-Murthy, Rohini; Lincoln, Anne G; Robson, Mark E; Guillem, Jose G; Markowitz, Arnold J; Offit, Kenneth; Stadler, Zsofia K

    2017-04-01

    Few reports of educational and counseling support resources exist for Lynch syndrome (LS), a disorder requiring multi-organ cancer screening and specialized medical care throughout adult life. Here we describe the development and efficacy of two resources designed to address this need, the Memorial Sloan Kettering Cancer Center Clinical Genetics Service annual Lynch Syndrome Educational Workshop (LSEW), and a quarterly Lynch Syndrome Patient Advocacy Network (LSPAN) support group. The LSEW and LSPAN were implemented beginning in 2012. Participant survey data evaluating satisfaction, clarity, and unmet needs for each event were retrospectively analyzed and summarized using descriptive statistics. Annual LSEW attendance ranged from 53 to 75 total participants. LSEW year 1 participants indicated a need for a support group, and preferred in-person meetings at a frequency of every 3-6 months. For LSEW year 2-5 participants, >96 % reported satisfaction with the LSEW, and >82 % expressed interest in secure online support. Common themes for improvement included increased time for question and answer sessions and additional introductory genetics education. Responding LSPAN participants (n = 57 total survey responses in 11 meetings) found the meetings helpful (100 %), information clear (91 %), and presence of a genetic counselor useful (67 %). Desired discussion topics included coping with stress and anxiety, development of a support network, family communication about LS, genetic testing decisions, and bereavement. Following genetic counseling, a need exists for ongoing educational and emotional support in LS. Implementation of resources such as the LSEW and LSPAN is feasible and perceived as helpful by participants.

  19. Is there evidence that we should screen the general population for Lynch syndrome with genetic testing? A systematic review

    Science.gov (United States)

    Prince, Anya E R; Cadigan, R Jean; Henderson, Gail E; Evans, James P; Adams, Michael; Coker-Schwimmer, Emmanuel; Penn, Dolly C; Van Riper, Marcia; Corbie-Smith, Giselle; Jonas, Daniel E

    2017-01-01

    Background The emerging dual imperatives of personalized medicine and technologic advances make population screening for preventable conditions resulting from genetic alterations a realistic possibility. Lynch syndrome is a potential screening target due to its prevalence, penetrance, and the availability of well-established, preventive interventions. However, while population screening may lower incidence of preventable conditions, implementation without evidence may lead to unintentional harms. We examined the literature to determine whether evidence exists that screening for Lynch-associated mismatch repair (MMR) gene mutations leads to improved overall survival, cancer-specific survival, or quality of life. Documenting evidence and gaps is critical to implementing genomic approaches in public health and guiding future research. Materials and methods Our 2014–2015 systematic review identified studies comparing screening with no screening in the general population, and controlled studies assessing analytic validity of targeted next-generation sequencing, and benefits or harms of interventions or screening. We conducted meta-analyses for the association between early or more frequent colonoscopies and health outcomes. Results Twelve studies met our eligibility criteria. No adequate evidence directly addressed the main question or the harms of screening in the general population. Meta-analyses found relative reductions of 68% for colorectal cancer incidence (relative risk: 0.32, 95% confidence interval: 0.23–0.43, three cohort studies, 590 participants) and 78% for all-cause mortality (relative risk: 0.22, 95% confidence interval: 0.09–0.56, three cohort studies, 590 participants) for early or more frequent colonoscopies among family members of people with cancer who also had an associated MMR gene mutation. Conclusion Inadequate evidence exists examining harms and benefits of population-based screening for Lynch syndrome. Lack of evidence highlights the need

  20. Management strategies in Lynch syndrome and familial adenomatous polyposis: a national healthcare survey in Japan.

    Science.gov (United States)

    Yamano, Tomoki; Hamanaka, Michiko; Babaya, Akihito; Kimura, Kei; Kobayashi, Masayoshi; Fukumoto, Miki; Tsukamoto, Kiyoshi; Noda, Masafumi; Matsubara, Nagahide; Tomita, Naohiro; Sugihara, Kenichi

    2017-02-01

    Lynch syndrome (LS) and familial adenomatous polyposis (FAP) are major sources of hereditary colorectal cancer (CRC) and are associated with other malignancies. There is some heterogeneity in management strategies in Japan. We undertook a survey of management of hereditary CRC in hospitals that are members of the Japan Society of Colorectal Cancer Research. One hundred and ninety departments responded, of which 127 were from designated cancer care hospitals (DCCHs) according to the Japanese government. There were 25 488 operations for CRC in these departments in 2015. The DCCHs performed better with regard to usage of Japan Society of Colorectal Cancer Research guidelines, referring new CRC patients for LS screening, and having in-house genetic counselors and knowledge of treatment for LS. There were 174 patients diagnosed with LS and 602 undergoing follow-up in 2011-2015, which is fewer than the number expected from CRC operations in 2015. These numbers were not affected by whether the institution was a DCCH. Universal screening for LS was carried out in 8% of the departments. In contrast, 541 patients were diagnosed with FAP and 273 received preventive proctocolectomy/colectomy in 2011-2015. The DCCH departments undertook more surgery than non-DCCH departments, although most of the management, including surgical procedures and use of non-steroidal anti-inflammatory drugs, was similar. Management of desmoid tumor in the abdominal cavity differed according to the number of patients treated. In conclusion, there was heterogeneity in management of LS but not FAP. Most patients with LS may be overlooked and universal screening for LS is not common in Japan.

  1. Prevalence of Lynch syndrome in a Middle Eastern population with colorectal cancer.

    Science.gov (United States)

    Siraj, Abdul K; Prabhakaran, Sarita; Bavi, Prashant; Bu, Rong; Beg, Shaham; Hazmi, Mohsen Al; Al-Rasheed, Maha; Al-Assiri, Mohammed; Sairafi, Rami; Al-Dayel, Fouad; Al-Sanea, Nasser; Uddin, Shahab; Al-Kuraya, Khawla S

    2015-06-01

    Lynch syndrome (LS; hereditary nonpolyposis colorectal cancer) is a common cause of hereditary colorectal cancer (CRC). CRC is the most common cancer diagnosed among males in Saudi Arabia but to the authors' knowledge there is a lack of data regarding the prevalence of LS in patients with CRC. There currently are no clear guidelines for the selection criteria for these patients to screen for LS. A comprehensive molecular characterization was performed in a cohort of 807 CRC cases by immunohistochemical and microsatellite analysis using polymerase chain reaction. BRAF mutation screening, high CpG island methylator phenotype, and analysis for germline mutations were performed in 425 CRC samples. These were all high microsatellite instability (MSI-H) samples (91 cases), all low MSI samples (143 cases), and selected cases from the microsatellite stable group (191 cases) that met revised Bethesda guidelines. Polymerase chain reaction identified 91 MSI-H cases (11.3%) and sequencing revealed mismatch repair germline mutations in 8 CRC cases only. Of the total of 807 CRC cases, these 8 cases (0.99%) were MSI-H, met the revised Bethesda guidelines, and did not harbor BRAF mutations. The results of the current study confirmed cases of LS in approximately 1.0% of CRC samples and reflects the efficacy of screening among MSI-H cases that lack BRAF mutations. This comprehensive study from Saudi Arabia will help in implementing a universal screening/reflex testing strategy in a clinical setting in Saudi Arabia and in conducting a national screening program that benefits both patients and their relatives. © 2015 American Cancer Society.

  2. Aspirin, Ibuprofen, and the Risk for Colorectal Cancer in Lynch Syndrome

    Science.gov (United States)

    Ait Ouakrim, Driss; Dashti, Seyedeh Ghazaleh; Chau, Rowena; Buchanan, Daniel D.; Clendenning, Mark; Rosty, Christophe; Winship, Ingrid M.; Young, Joanne P.; Giles, Graham G.; Leggett, Barbara; Macrae, Finlay A.; Ahnen, Dennis J.; Casey, Graham; Gallinger, Steven; Haile, Robert W.; Le Marchand, Loïc; Thibodeau, Stephen N.; Lindor, Noralane M.; Newcomb, Polly A.; Potter, John D.; Baron, John A.; Hopper, John L.; Jenkins, Mark A.

    2015-01-01

    Background: Inheritance of a germline mutation in one of the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 causes a high risk of colorectal and other cancers (Lynch Syndrome). Use of aspirin has been shown to be associated with a reduced risk of colorectal cancer for the general population as well as for MMR gene mutation carriers. The aim of this study was to determine whether use of aspirin and ibuprofen in a nontrial setting is associated with the risk of colorectal cancer risk for MMR gene mutation carriers. Methods: We included 1858 participants in the Colon Cancer Family Registry who had been found to have a pathogenic germline mutation in a MMR gene (carriers). We used weighted Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). All statistical tests were two-sided. Results: A total of 714 carriers (38%) were diagnosed with colorectal cancer at a mean age of 42.4 (standard deviation 10.6) years. A reduced risk of colorectal cancer was associated with aspirin use (for 1 month to 4.9 years: HR = 0.49, 95% CI = 0.27 to 0.90, P = .02; for ≥5 years: HR = 0.25, 95% CI = 0.10 to 0.62, P = .003) and ibuprofen use (for 1 month to 4.9 years: HR = 0.38, 95% CI = 0.18 to 0.79, P = .009; for ≥5 years: HR = 0.26, 95% CI = 0.10 to 0.69, P = .007), compared with less than one month of use. Conclusion: Our results provide additional evidence that, for MMR gene mutation carriers, use of aspirin and ibuprofen might be effective in reducing their high risk of colorectal cancer. PMID:26109217

  3. A Systematic Review on the Existing Screening Pathways for Lynch Syndrome Identification

    Directory of Open Access Journals (Sweden)

    Alessia Tognetto

    2017-09-01

    Full Text Available BackgroundLynch syndrome (LS is the most common hereditary colon cancer syndrome, accounting for 3–5% of colorectal cancer (CRC cases, and it is associated with the development of other cancers. Early detection of individuals with LS is relevant, since they can take advantage of life-saving intensive care surveillance. The debate regarding the best screening policy, however, is far from being concluded. This prompted us to conduct a systematic review of the existing screening pathways for LS.MethodsWe performed a systematic search of MEDLINE, ISI Web of Science, and SCOPUS online databases for the existing screening pathways for LS. The eligibility criteria for inclusion in this review required that the studies evaluated a structured and permanent screening pathway for the identification of LS carriers. The effectiveness of the pathways was analyzed in terms of LS detection rate.ResultsWe identified five eligible studies. All the LS screening pathways started from CRC cases, of which three followed a universal screening approach. Concerning the laboratory procedures, the pathways used immunohistochemistry and/or microsatellite instability testing. If the responses of the tests indicated a risk for LS, the genetic counseling, performed by a geneticist or a genetic counselor, was mandatory to undergo DNA genetic testing. The overall LS detection rate ranged from 0 to 5.2%.ConclusionThis systematic review reported different existing pathways for the identification of LS patients. Although current clinical guidelines suggest to test all the CRC cases to identify LS cases, the actual implementation of pathways for LS identification has not been realized. Large-scale screening programs for LS have the potential to reduce morbidity and mortality for CRC, but coordinated efforts in educating all key stakeholders and addressing public needs are still required.

  4. Lynch syndrome and exposure to aristolochic acid in upper-tract urothelial carcinoma: its clinical impact?

    Science.gov (United States)

    Colin, Pierre; Seisen, Thomas; Mathieu, Romain; Shariat, Sharohkh F.

    2016-01-01

    The purpose of the current review was to describe the clinical risk for Lynch syndrome (LS) after exposure to aristolochic acid (AA) in cases of upper urinary-tract urothelial carcinoma (UTUC). A systematic review of the scientific literature was performed using the Medline database (National Library of Medicine, PubMed) using the following keywords: epidemiology, risk factor, AA, Balkan nephropathy (BNe), LS, hereditary cancer, hereditary non-polyposis colorectal cancer (HNPCC), mismatch repair genes, urothelial carcinomas, upper urinary tract, renal pelvis, ureter, Amsterdam criteria, genetic counselling, mismatch repair genes, genetic instability, microsatellite, and Bethesda guidelines. LS is a specific risk for UTUC, which is the third most frequent cancer (in its tumor spectrum) after colon and uterine lesions. Mutation of the MSH2 gene is the most commonly described cause of UTUC in LS. Diagnosis is based on clinical suspicion and is guided by Bethesda and Amsterdam criteria. It is secondarily confirmed by immunohistochemical analyses of the tumor and a search for gene mutations. The presence of LS in patients with UTUC is a favorable prognosis factor for survival during follow-ups. AA is a specific environmental risk factor for UTUC and tubulo-interstitial nephropathy. It has been involved in the development of nephropathies in link with the Balkan disease and intake of Chinese herbal medicine. More broadly, the use of traditional plant medicines from the genus Aristolochia has created worldwide public-health concerns. UTUCs share common risk factors with other urothelial carcinomas such as tobacco or occupational exposure. However, these tumors have also specific risk factors such as AA exposure and LS that clinicians should be aware of because of their clinical implication in further management and follow-up.

  5. MLH1 promoter hypermethylation in the analytical algorithm of Lynch syndrome: a cost-effectiveness study

    Science.gov (United States)

    Gausachs, Mireia; Mur, Pilar; Corral, Julieta; Pineda, Marta; González, Sara; Benito, Llúcia; Menéndez, Mireia; Espinàs, Josep Alfons; Brunet, Joan; Iniesta, María Dolores; Gruber, Stephen B; Lázaro, Conxi; Blanco, Ignacio; Capellá, Gabriel

    2012-01-01

    The analytical algorithm of Lynch syndrome (LS) is increasingly complex. BRAF V600E mutation and MLH1 promoter hypermethylation have been proposed as a screening tool for the identification of LS. The aim of this study was to assess the clinical usefulness and cost-effectiveness of both somatic alterations to improve the yield of the diagnostic algorithm of LS. A total of 122 colorectal tumors from individuals with family history of colorectal cancer that showed microsatellite instability and/or loss of mismatch repair (MMR) protein expression were studied. MMR germline mutations were detected in 57 cases (40 MLH1, 15 MSH2 and 2 MSH6). BRAF V600E mutation was assessed by single-nucleotide primer extension. MLH1 promoter hypermethylation was assessed by methylation-specific multiplex ligation-dependent probe amplification in a subset of 71 cases with loss of MLH1 protein. A decision model was developed to estimate the incremental costs of alternative case-finding methods for detecting MLH1 mutation carriers. One-way sensitivity analysis was performed to assess robustness of estimations. Sensitivity of the absence of BRAF mutations for depiction of LS patients was 96% (23/24) and specificity was 28% (13/47). Specificity of MLH1 promoter hypermethylation for depiction of sporadic tumors was 66% (31/47) and sensitivity of 96% (23/24). The cost per additional mutation detected when using hypermethylation analysis was lower when compared with BRAF study and germinal MLH1 mutation study. Somatic hypermethylation of MLH1 is an accurate and cost-effective pre-screening method in the selection of patients that are candidates for MLH1 germline analysis when LS is suspected and MLH1 protein expression is absent. PMID:22274583

  6. Iconografía, música y narración en Wild at Heart, de David Lynch

    OpenAIRE

    García Escrivá, Vicente

    2011-01-01

    El análisis del texto fílmico Corazón Salvaje (Wild at Heart, David Lynch, EEUU, 1990) permite localizar toda una serie de rasgos característicos de la narrativa y la estética cinematográfica posmoderna. Por un lado, el film presenta una notable descomposición narrativa, lo que se traduce en una sucesión de escenas un tanto inconexas, a modo de cuadros intensos pero poco trabados. Asimismo, en la película se produce una suerte de hibridación de géneros, aglutinados por un tono general de paro...

  7. The role of religious and existential well-being in families with Lynch syndrome: prevention, family communication, and psychosocial adjustment.

    Science.gov (United States)

    Morris, Bronwyn A; Hadley, Donald W; Koehly, Laura M

    2013-08-01

    This study explored the role of religious (RWB) and existential well-being (EWB) on psychosocial factors, support network characteristics, and screening practices in families with Lynch syndrome, also referred to as hereditary nonpolyposis colon cancer (HNPCC). Participants were individuals with Lynch syndrome associated cancers and their first-degree relatives at risk of inheriting an identified deleterious mutation. Analyses considered both family RWB and EWB norms and individual deviations from that norm. Analyses controlled for age, gender, cancer diagnosis, number of respondents, and network size. Higher family RWB was associated with increased depressive symptoms (p family EWB was related to decreased depression symptoms (p family EWB was associated with fecal occult blood testing (p family communication about genetic counselling and testing (p family-level effects. Individuals with lower EWB than their family had lower perceived risk for colorectal cancer (p communicated disease risk information to less family members (p family also had higher cancer worry (p family network and being aware of family characteristics which may impact individual adjustment to disease risk. Interventions considering family-level factors may provide efficient pathways to improving psychosocial factors, screening practices, communication about disease risk and genetic testing, and cancer prevention.

  8. Cost-Effectiveness Analysis of Different Genetic Testing Strategies for Lynch Syndrome in Taiwan.

    Science.gov (United States)

    Chen, Ying-Erh; Kao, Sung-Shuo; Chung, Ren-Hua

    2016-01-01

    Patients with Lynch syndrome (LS) have a significantly increased risk of developing colorectal cancer (CRC) and other cancers. Genetic screening for LS among patients with newly diagnosed CRC aims to identify mutations in the disease-causing genes (i.e., the DNA mismatch repair genes) in the patients, to offer genetic testing for relatives of the patients with the mutations, and then to provide early prevention for the relatives with the mutations. Several genetic tests are available for LS, such as DNA sequencing for MMR genes and tumor testing using microsatellite instability and immunohistochemical analyses. Cost-effectiveness analyses of different genetic testing strategies for LS have been performed in several studies from different countries such as the US and Germany. However, a cost-effectiveness analysis for the testing has not yet been performed in Taiwan. In this study, we evaluated the cost-effectiveness of four genetic testing strategies for LS described in previous studies, while population-specific parameters, such as the mutation rates of the DNA mismatch repair genes and treatment costs for CRC in Taiwan, were used. The incremental cost-effectiveness ratios based on discounted life years gained due to genetic screening were calculated for the strategies relative to no screening and to the previous strategy. Using the World Health Organization standard, which was defined based on Taiwan's Gross Domestic Product per capita, the strategy based on immunohistochemistry as a genetic test followed by BRAF mutation testing was considered to be highly cost-effective relative to no screening. Our probabilistic sensitivity analysis results also suggest that the strategy has a probability of 0.939 of being cost-effective relative to no screening based on the commonly used threshold of $50,000 to determine cost-effectiveness. To the best of our knowledge, this is the first cost-effectiveness analysis for evaluating different genetic testing strategies for LS in

  9. Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome : the GEOLynch cohort study

    NARCIS (Netherlands)

    Jung, Audrey Y.; van Duijnhoven, Franzel J. B.; Nagengast, Fokko M.; Botma, Akke; Heine-Broring, Renate C.; Kleibeuker, Jan H.; Vasen, Hans F. A.; Harryvan, Jan L.; Winkels, Renate M.; Kampman, Ellen

    Dietary intake of B vitamins and methionine, essential components of DNA synthesis and methylation pathways, may influence colorectal tumor (CRT) development. The impact of B vitamins on colorectal carcinogenesis in individuals with Lynch syndrome (LS) is unknown but is important given their high

  10. Ovarian metastasis from uveal melanoma with MLH1/PMS2 protein loss in a patient with germline MLH1 mutated Lynch syndrome: consequence or coincidence?

    Science.gov (United States)

    Lobo, João; Pinto, Carla; Freitas, Micaela; Pinheiro, Manuela; Vizcaino, Rámon; Oliva, Esther; Teixeira, Manuel R; Jerónimo, Carmen; Bartosch, Carla

    2017-03-01

    Currently, uveal melanoma is not considered within the Lynch syndrome tumor spectrum. However, there are studies suggesting a contribution of microsatellite instability in sporadic uveal melanoma tumorigenesis. We report a 45-year-old woman who was referred for genetic counseling due to a family history of Lynch syndrome caused by a MLH1 mutation. She originally underwent enucleation of the right eye secondary to a uveal spindle cell melanoma diagnosed at age 25. The tumor recurred 22 years later presenting as an ovarian metastasis and concurrently a microscopic endometrial endometrioid carcinoma, grade 1/3 was diagnosed. Subsequent studies highlighted that the uveal melanoma showed high microsatellite instability and loss of MLH1 and PMS2 protein expression, with no MLH1 promoter methylation or BRAF mutation. Additionally, a GNAQ mutation was found. We conclude that our patient's uveal melanoma is most likely related to MLH1 germline mutation and thus Lynch syndrome related. To the best of our knowledge, this is the first report of uveal melanoma showing MLH1/PMS2 protein loss in the context of Lynch syndrome.

  11. Los actos tienen consecuencias. Lógicas del mind-game film en la trilogía de Los Ángeles de David Lynch

    NARCIS (Netherlands)

    Elsaesser, T.

    2013-01-01

    Actions Do Have Consequences. Logics of the Mind-Game Film in David Lynch’s Los Angeles-Trilogy. David Lynch is a director, along with other auteurs, notably Michael Haneke and Lars von Trier, whose authorial identity and creative authority —and the challenges these encounter in the 21st century— ar

  12. Los actos tienen consecuencias. Lógicas del mind-game film en la trilogía de Los Ángeles de David Lynch

    NARCIS (Netherlands)

    Elsaesser, T.

    2013-01-01

    Actions Do Have Consequences. Logics of the Mind-Game Film in David Lynch’s Los Angeles-Trilogy. David Lynch is a director, along with other auteurs, notably Michael Haneke and Lars von Trier, whose authorial identity and creative authority —and the challenges these encounter in the 21st century—

  13. Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome : the GEOLynch cohort study

    NARCIS (Netherlands)

    Jung, Audrey Y.; van Duijnhoven, Franzel J. B.; Nagengast, Fokko M.; Botma, Akke; Heine-Broring, Renate C.; Kleibeuker, Jan H.; Vasen, Hans F. A.; Harryvan, Jan L.; Winkels, Renate M.; Kampman, Ellen

    2014-01-01

    Dietary intake of B vitamins and methionine, essential components of DNA synthesis and methylation pathways, may influence colorectal tumor (CRT) development. The impact of B vitamins on colorectal carcinogenesis in individuals with Lynch syndrome (LS) is unknown but is important given their high li

  14. A Patient with Cancer and Her Family in Caring Partnership Based on Margaret Newman's Theory of Health as Expanding Consciousness.

    Science.gov (United States)

    Fujiwara, Yoshimi; Endo, Emiko

    2017-01-01

    The purpose, on the basis of Margaret Newman's theory of health as expanding consciousness in a unitary perspective, was to practice the caring partnership with a client who could not share their desires and find their future direction at a gear change period and document the process of their relational changes within this process. The design was research as praxis. The participant was a patient with cancer and her family in the midst of a difficult health situation. Through caring partnership, a nurse researcher asked to tell "the meaningful events and relationships in their lives" over four in-depth dialogue meetings. Data were collected from the tape-recorded dialogue transcriptions. In the process of caring partnership, the patient and each family member recognized their own pattern and family pattern of "being closed off," their approach to the situation, and found a new direction through this process. The finding suggested that caring partnership as a nursing intervention would be helpful for nurses as well as for patients and their families in difficult health situations.

  15. Women’s Oppressed and Disfigured Life in Margaret Atwood’s The Handmaid’s Tale

    Directory of Open Access Journals (Sweden)

    Bahman Zarrinjooee

    2017-02-01

    Full Text Available The present study attempts to analyze Margaret Atwood’s (1939- The Handmaid’s Tale (1985 based on theories of feminist thinker, Simone de Beauvoir (1908-1986 and applies her theories presented in The Second Sex (1949 that leads to better apprehension of sex and gender. Beauvoir’s ideology focuses mainly on the cultural mechanisms of oppression which cause to confine women under the title of Other to man’s self. In her view woman cannot be a simple biological category, and she asserts that womanhood is imposed on woman by civilization. In her idea, the fundamental social meaning of woman is Other. She believes that biology is the main source for woman’s oppression within patriarchal society, and challenges the discourse through which women are defined based on her biology. She also believes that sexuality is another aspect of women’s oppression and exploitation and all functions of women. In Beauvoir’s view, prostitution and heterosexuality are exploitation of woman. She rejects the heterosexuality as the norm for sexual relations. This paper tries to show how Atwood in The Handmaid’s Tale speculates feminist issues such as loss of identity, subordination of woman in a male dominated society and women’s exploitation in consumer society where woman’s body is treated as an object, a tool and consumable item. Atwood focuses on the problems such as gender inequality, and pitfalls of patriarchal system for women’s oppression.

  16. Os riscos do texto e da imagem - Em torno de Balinese character (1942, de Gregory Bateson e Margaret Mead

    Directory of Open Access Journals (Sweden)

    Etienne Samain

    2000-11-01

    Full Text Available Balinese character. A photographie analysis (1942 de Gregory Bateson et Margaret Mead est, sans nul doute, un livre fondateur de l’anthropologie visuelle (photographique. Souvent cité, il reste insuffisamment exploré. Cet article soulève - après une brève présentation de l’organisation d’ensemble de l’oeuvre - un questionnement heuristique et une réflexion sur la nature de l’utilisation intégrative de l’image et du texte dans l’élaboration du discours anthropologique. Pour ce faire, nous étudions trois modèles d’organisation des planches photographiques de Balinese character et leurs respectifs commentaires écrits, effectuant des parcours inverses: de l’image au texte, du texte à l’image. S’il est vrai que l'un et l’autre de ces supports communicationnels sont singuliers autant que complémentaires, leurs richesse respective n’est pas à l’abri d’autres risques que cette recherche dévoilera.

  17. 大卫·林奇的生平和作品%David Lynch's Biography and Filmmography

    Institute of Scientific and Technical Information of China (English)

    游飞

    2003-01-01

    @@ 生平 大卫·林奇(David Lynch)是现代美国电影创作的伟大复兴者,一个受到广泛赞誉的编剧兼导演,他还是电视制片人、摄影家、动画专家、作曲家和电脑影像艺术家.运用惊人的平衡感和技巧游走于主流电影和先锋电影的边缘,林奇为电影银幕带来一种怪诞、黑暗和诡异不安的真实感,一种由极端的暴力、怪异的喜剧和奇妙的美丽为特征的噩梦世界.

  18. Temperature profiles from expendable bathythermograph (XBT) casts from the LYNCH in the North Atlantic Ocean in support of the Integrated Global Ocean Services System (IGOSS) project from 26 June 1973 to 14 July 1973 (NODC Accession 7301081)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — XBT data were collected from the LYNCH in support of the Integrated Global Ocean Services System (IGOSS) project. Data were collected US Navy; Naval Oceanographic...

  19. Crossing Human Boundaries: Apocalypse and Posthumanism in Margaret Atwood’s Oryx and Crake and The Year of the Flood

    Directory of Open Access Journals (Sweden)

    Valeria Mosca

    2013-05-01

    Full Text Available Margaret Atwood’s Oryx and Crake (2003 and The Year of the Flood (2009 are the first and second novels in an as-yet-unfinished trilogy. The two works share a complex structure in which scenes from different moments in the future follow one another. A post-apocalyptic narrative line is intertwined with one that depicts events from a nearer future, all of them leading up to an environmental catastrophe of huge proportions. The nearest scenario is one of extreme genetic manipulation, in which the boundaries between species are blatantly crossed. Biopolitics strictly controls the environment and those who inhabit it; identities can be bought, and only some of them grant access to the Compounds – the only safe areas left after open spaces have become radioactive. In the meantime, all kinds of technological and genetic enhancements to human capabilities are being employed, some of them resulting in the creation of para-human populations. An environmental catastrophe follows, and both books feature last-man-on-earth narratives. Whether – or, more appropriately, how – the apocalyptic destruction is linked to an attempt to cross the boundary of the human is the issue this essay addresses. The first section deals with more classical interpretations of Atwood’s fiction as a cautionary tale about current environmental policies, whereas a new hypothesis is made in the second section, a post-humanist reading of Atwood's novels. Philosophical support will be provided by Jacques Derrida’s reflections on the fine line between animals and humans and Cary Wolfe’s theory of posthumanism.

  20. A Study of Hélène Cixous’ Concepts of Neuter and Other in Margaret Atwood’s Life before Man

    Directory of Open Access Journals (Sweden)

    Shahram Afrougheh

    2014-05-01

    Full Text Available This study tries to find the evidences of similarity in thoughts and beliefs common between two female writers, Hélène Cixous and Margaret Atwood; therefore, the main concepts, neuter and other that  Cixous introduced and discussed by means of her Feminine writing, are applied in Atwood’s novel, Life before Man. The research is done by studying the main characters of the above-mentioned novel. The results show that none of characters is able to cope and connect with other that leads to their unhappy lives and their failure.

  1. The Conflict and Reconciliation between the Two Societies--An Interpretation of the Novel"I Heard the Owl Call my Name" by Margaret Craven

    Institute of Scientific and Technical Information of China (English)

    严淑琼

    2001-01-01

    For a long time Indians have remained a mystery to people not only in America but also in other parts of the world. The little that is known about them certainly makes people want to know a great deal more. Indian' s unique culture, customs and values are exciting the immense interest of all. Under such circumstances the novel"I Heard the Owl Call My Name"written by Margaret Craven achieves much popularity and captures great attention of all. The focus of this paper is on the cultural conflict and reconciliation between Indians and the non-native people.

  2. The Uterine Sandwich Method for Placenta Previa Accreta in Mullerian Anomaly: Combining the B-Lynch Compression Suture and an Intrauterine Gauze Tampon

    Directory of Open Access Journals (Sweden)

    Mustafa Kaplanoğlu

    2013-01-01

    Full Text Available Mullerian duct anomalies may cause obstetric complications, such as postpartum hemorrhage (PPH and placental adhesion anomalies. Uterine compression suture may be useful for controlling PPH (especially atony. In recent studies, uterine compression sutures have been used in placenta accreta. We report a case of PPH, a placenta accreta accompanying a large septae, treated with B-Lynch suture and intrauterine gauze tampon.

  3. Ambiguity and the Ethics of Reading Race and Lynching in James W. Johnson’s The Autobiography of an Ex-Colored Man (1912

    Directory of Open Access Journals (Sweden)

    Dexl, Carmen

    2009-01-01

    Full Text Available James Weldon Johnson’s novel The Autobiography of an Ex-Colored Man (1912 discusses the causes, conditions, and implications of passing in a segregated society. The essay argues that the novel’s aesthetics of ambiguity conveys and reflects an ambivalence towards the concept of race. Using theories of Geoffrey Galt Harpham and John Guillory, it elaborates an ethics of reading race and lynching in The Autobiography of an Ex-Colored Man.

  4. Effect of low B-Lynch suture on menstrual cycle recovery and sex hormone levels in patients after cesarean section for placenta previa

    Institute of Scientific and Technical Information of China (English)

    Su-Lan Zhang; Wan-Cheng Feng; Yan Mi

    2016-01-01

    Objective:To explore the effect of low B-Lynch suture on the menstrual cycle recovery and sex hormone levels in patients after cesarean section for placenta previa.Methods:A total of 40 patients who were admitted in our hospital from August, 2013 to August, 2015 for cesarean section due to placenta previa were included in the study and randomized into the observation group and the control group. The patients in the observation group were given low B-lynch suture, while in the control group, yarns were plugged in the uterus. The bleeding during operation and 24 h after operation, the postpartum lochia duration, and menstrual cycle recovery in the two groups were observed. The postpartum FSH, E2, and LH levels in the two groups were determined.Results:The amount of bleeding during operation and 24 h after operation in the observation group was significantly less than that in the control group (P0.05). The comparison of FSH, E2, and LH levels between the two groups was not statistically significant (P>0.05).Conclusions:Low B-Lynch suture can effectively reduce the amount of bleeding after cesarean section for placenta previa, and has no effect on the menstrual recovery and ovarian function with a simple operation and less postoperative complications; therefore, it deserves to be widely recommended in the clinic.

  5. LINCHAMENTO: O CRESCIMENTO DA (INJUSTIÇA COLETIVA DIANTE DA OMISSÃO DO ESTADO / LYNCHING: GROWTH OF PUBLIC (INJUSTICE FRONT THE FAILURE OF THE STATE

    Directory of Open Access Journals (Sweden)

    Sarah Ludmilla do Nascimento Félix

    2015-12-01

    Full Text Available This article presents the relationship between the increase in the number of lynching in Brazil and the omission of state to comply with its duty to punish and reintegrate of offenders into community. It is explained the origins and causes of the phenomenon and its use as a form of exhibitionism punishment. Additionally, it is showed how the state inaction in combating crime allows the occurrence of private punishment and encourages its practice. It is exposed the relationship between this lethargy and the growth in crime rates which creates a cycle of violence. It is used literature review as a research methodology and it is analyzed fundamental rights and constitutional guarantees and the intolerable disrespect in relation to the case of lynched people. It is indicated that these offenses are the main reason to start an effective combat against the practice of lynching. It is justified why government needs to work together with civil society in pursuing an effective security policies and investments to combat factors that cause violence in Brazil and the mechanisms to avoid these criminal offenses.

  6. Geochemical and geophysical examination of submarine groundwater discharge and associated nutrient loading estimates into Lynch Cove, Hood Canal, WA

    Science.gov (United States)

    Swarzenski, P.W.; Simonds, F.W.; Paulson, A.J.; Kruse, S.; Reich, C.

    2007-01-01

    Geochemical tracer data (i.e., 222Rn and four naturally occurring Ra isotopes), electromagnetic (EM) seepage meter results, and high-resolution, stationary electrical resistivity images were used to examine the bi-directional (i.e., submarine groundwater discharge and recharge) exchange of a coastal aquifer with seawater. Our study site for these experiments was Lynch Cove, the terminus of Hood Canal, WA, where fjord-like conditions dramatically limit water column circulation that can lead to recurring summer-time hypoxic events. In such a system a precise nutrient budget may be particularly sensitive to groundwater-derived nutrient loading. Shore-perpendicular time-series subsurface resistivity profiles show clear, decimeter-scale tidal modulation of the coastal aquifer in response to large, regional hydraulic gradients, hydrologically transmissive glacial terrain, and large (4-5 m) tidal amplitudes. A 5-day 222Rn time-series shows a strong inverse covariance between 222Rn activities (0.5−29 dpm L-1) and water level fluctuations, and provides compelling evidence for tidally modulated exchange of groundwater across the sediment/water interface. Mean Rn-derived submarine groundwater discharge (SGD) rates of 85 ± 84 cm d-1 agree closely in the timing and magnitude with EM seepage meter results that showed discharge during low tide and recharge during high tide events. To evaluate the importance of fresh versus saline SGD, Rn-derived SGD rates (as a proxy of total SGD) were compared to excess 226Ra-derived SGD rates (as a proxy for the saline contribution of SGD). The calculated SGD rates, which include a significant (>80%) component of recycled seawater, are used to estimate associated nutrient (NH4+, Si, PO43-, NO3 + NO2, TDN) loads to Lynch Cove. The dissolved inorganic nitrogen (DIN = NH4 + NO2 + NO3) SGD loading estimate of 5.9 × 104 mol d-1 is 1−2 orders of magnitude larger than similar estimates derived from atmospheric deposition and surface water runoff

  7. Geochemical and geophysical examination of submarine groundwater discharge and associated nutrient loading estimates into Lynch Cove, Hood Canal, WA.

    Science.gov (United States)

    Swarzenski, Peter W; Simonds, F William; Paulson, Anthony J; Kruse, Sarah; Reich, Chris

    2007-10-15

    Geochemical tracer data (i.e., 222Rn and four naturally occurring Ra isotopes), electromagnetic (EM) seepage meter results, and high-resolution, stationary electrical resistivity images were used to examine the bi-directional (i.e., submarine groundwater discharge and recharge) exchange of a coastal aquifer with seawater. Our study site for these experiments was Lynch Cove, the terminus of Hood Canal, WA, where fjord-like conditions dramatically limit water column circulation that can lead to recurring summer-time hypoxic events. In such a system a precise nutrient budget may be particularly sensitive to groundwater-derived nutrient loading. Shore-perpendicular time-series subsurface resistivity profiles show clear, decimeter-scale tidal modulation of the coastal aquifer in response to large, regional hydraulic gradients, hydrologically transmissive glacial terrain, and large (4-5 m) tidal amplitudes. A 5-day 222Rn time-series shows a strong inverse covariance between 222Rn activities (0.5-29 dpm L(-1)) and water level fluctuations, and provides compelling evidence for tidally modulated exchange of groundwater across the sediment/water interface. Mean Rn-derived submarine groundwater discharge (SGD) rates of 85 +/- 84 cm d(-1) agree closely in the timing and magnitude with EM seepage meter results that showed discharge during low tide and recharge during high tide events. To evaluate the importance of fresh versus saline SGD, Rn-derived SGD rates (as a proxy of total SGD) were compared to excess 226Ra-derived SGD rates (as a proxy for the saline contribution of SGD). The calculated SGD rates, which include a significant (>80%) component of recycled seawater, are used to estimate associated nutrient (NH4+, Si, PO4(3-), NO3 + NO2, TDN) loads to Lynch Cove. The dissolved inorganic nitrogen (DIN = NH4 + NO2 + NO3) SGD loading estimate of 5.9 x 10(4) mol d(-1) is 1-2 orders of magnitude larger than similar estimates derived from atmospheric deposition and surface water

  8. Linchamientos y conflicto político en Los Andes Lynchings and Political conflict in The Andes

    Directory of Open Access Journals (Sweden)

    Carlos M. Vilas

    2007-06-01

    Full Text Available En 2004, los alcaldes de dos municipalidades de la región aimara de los Andes fueron linchados en la aparente culminación de agudos conflictos políticos internos y entre las respectivas comunidades y el Estado central. En este artículo se discuten ambos casos con el fin de ilustrar las transformaciones experimentadas en años recientes en la organización y la dinámica interna de las comunidades andinas, y de la articulación conflictiva de la política local en los procesos e instituciones de más amplio alcance. Precariedad social e incapacidad o renuencia del Estado para responder con eficacia a demandas básicas de determinados grupos de población configuran enmarcamientos socioeconómicos e institucionales de los linchamientos. En contraste con enfoques que enfatizan en factores culturales tradicionales o en un supuesto nacionalismo indígena, en el artículo se destaca la gravitación de fenómenos y procesos político- institucionales recientes en la transformación cultural y política de las comunidades, en el modo en que éstas procesan sus conflictos internos y con el Estado central.In 2004, two municipalitys mayors form the aimara Andes of Peru and Bolivia were subjected to mass lynchings as a result of the apparent culmination of violent political confrontations. This paper deals with these events as dramatic illustrations of the transformations the Andean communities experienced during recent decades in their internal dynamics, as well as in the articulation of local politics to processes and institutions beyond the communal limits. Structural precariousness combined with the state's inability or reluctance to come to terms with social or political demands from relevant segments of the people in the communities set the socioeconomic and institutional stage for lynchings. In contrast with approaches relating these events to an alleged indigenous cultural identity, the analysis points to the impact of the communities' political

  9. Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic

    Institute of Scientific and Technical Information of China (English)

    Patrícia Koehler-Santos; Mario Antonello Rosito; Patricia Ashton-Prolla; Jo(a)o Carlos Prolla; Patricia Izetti; Jamile Abud; Carlos Eduardo Pitroski; Silvia Liliana Cossio; Suzi Alves Camey; Cláudio Tarta; Daniel C Damin; Paulo Carvalho Contu

    2011-01-01

    AIM: To determine the prevalence of a family history suggestive of Lynch syndrome (LS) among patients with colorectal cancer (CRC) followed in a coloproctology outpatient clinic in Southern Brazil.METHODS: A consecutive sample of patients with CRC were interviewed regarding personal and family histories of cancer. Clinical data and pathology features of the tumor were obtained from chart review.RESULTS: Of the 212 CRC patients recruited, 61 (29%)reported a family history of CRC, 45 (21.2%) were diagnosed under age 50 years and 11 (5.2%) had more than one primary CRC. Family histories consistent with Amsterdam and revised Bethesda criteria for LS were identified in 22 (10.4%) and 100 (47.2%) patients,respectively. Twenty percent of the colorectal tumors had features of the high microsatellite instability phenotype,which was associated with younger age at CRC diagnosis and with Bethesda criteria (P < 0.001). Only 5.3% of the patients above age 50 years had been previously submitted for CRC screening and only 4% of patients with suspected LS were referred for genetic risk assessment.CONCLUSION: A significant proportion of patients with CRC were at high risk for LS. Education and training of health care professionals are essential to ensure proper management.

  10. Bayesian Modeling for Genetic Anticipation in Presence of Mutational Heterogeneity: A Case-Study in Lynch Syndrome

    Science.gov (United States)

    Boonstra, Philip S.; Mukherjee, Bhramar; Taylor, Jeremy M. G.; Nilbert, Mef; Moreno, Victor M.; Gruber, Stephen B.

    2011-01-01

    Summary Genetic anticipation, described by earlier age of onset (AOO) and more aggressive symptoms in successive generations, is a phenomenon noted in certain hereditary diseases. Its extent may vary between families and/or between mutation sub-types known to be associated with the disease phenotype. In this paper, we posit a Bayesian approach to infer genetic anticipation under flexible random effects models for censored data that capture the effect of successive generations on AOO. Primary interest lies in the random effects. Misspecifying the distribution of random effects may result in incorrect inferential conclusions. We compare the fit of four candidate random effects distributions via Bayesian model fit diagnostics. A related statistical issue here is isolating the confounding effect of changes in secular trends, screening and medical practices that may affect time to disease detection across birth cohorts. Using historic cancer registry data, we borrow from relative survival analysis methods to adjust for changes in age-specific incidence across birth cohorts. Our motivating case-study comes from a Danish cancer register of 124 families with mutations in mismatch repair genes known to cause hereditary non-polyposis colorectal cancer, also called Lynch syndrome. We find evidence for a decrease in AOO between generations in this study. Our model predicts family level anticipation effects which are potentially useful in genetic counseling clinics for high risk families. PMID:21627626

  11. Quotes from Margaret Thatcher

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    “不错,我是铁娘子。我捍卫的是对我们生活方式至关重要的价值观和自由,如果他们是想诠释我的这种行为,那么,不错,我就是铁娘子。”——1976年,对芬奇利保守党发表的演说。

  12. Beuysiga, Beuysita / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2011-01-01

    Düsseldorfis toimunud retrospektiivnäituse "Joseph Beuys. Paralleelsed protsessid" kaudu analüüsitakse, kuidas performance'ikunsti praktikad kunstiajaloo narratiivi kirjutatakse ja mis nendega seal juhtuda võib. Tegevuskunsti arhiveerimisest

  13. Nomination of Margaret Spellings. Hearing of the Committee on Health, Education, Labor, and Pensions, United States Senate, One Hundred Ninth Congress, First Session (January 6, 2005) S. Hrg. 109-88

    Science.gov (United States)

    US Senate, 2005

    2005-01-01

    The Senate Health, Education, Labor, and Pensions Committee held a hearing on the nomination of Margaret Spellings to be Secretary of Education. Statements were presented by: Michael B. Enzi, Chairman, Committee on Health, Education, Labor, and Pensions; Edward M. Kennedy, a U.S. Senator from the State of Massachusetts; Kay Bailey Hutchison, a…

  14. From Parody to Rewriting: Margaret Mitchell’s GoneWith the Wind (1936 vs Alice Randall’s The Wind Done Gone (2001 De la parodie à la réécriture : Margaret Mitchell’s Gone With the Wind (1936 vs Alice Randall’s The Wind Done Gone  (2001

    Directory of Open Access Journals (Sweden)

    Isabelle Roblin

    2009-11-01

    Full Text Available When after many difficulties, Alice Randall published The Wind Done Gone, the question of the very nature of the novel came to the foreground, from a constitutional as well as a literary standpoint: was it a parodic re-writing of Margaret Mitchell’s Gone With the Wind, and as such protected by the First Amendment; or was it just a “steal” of famous characters and situations, and as such submitted to the strict laws of copyright? The analysis of the various literary devices used by the author will show the subversive nature of the hypertext, which goes beyond simple parody.

  15. Functional testing strategy for coding genetic variants of unclear significance in MLH1 in Lynch syndrome diagnosis.

    Science.gov (United States)

    Hinrichsen, Inga; Schäfer, Dieter; Langer, Deborah; Köger, Nicole; Wittmann, Margarethe; Aretz, Stefan; Steinke, Verena; Holzapfel, Stefanie; Trojan, Jörg; König, Rainer; Zeuzem, Stefan; Brieger, Angela; Plotz, Guido

    2015-02-01

    Lynch syndrome is caused by inactivating mutations in the MLH1 gene, but genetic variants of unclear significance frequently preclude diagnosis. Functional testing can reveal variant-conferred defects in gene or protein function. Based on functional defect frequencies and clinical applicability of test systems, we developed a functional testing strategy aimed at efficiently detecting pathogenic defects in coding MLH1 variants. In this strategy, tests of repair activity and expression are prioritized over analyses of subcellular protein localization and messenger RNA (mRNA) formation. This strategy was used for four unclear coding MLH1 variants (p.Asp41His, p.Leu507Phe, p.Gln689Arg, p.Glu605del + p.Val716Met). Expression was analyzed using a transfection system, mismatch repair (MMR) activity by complementation in vitro, mRNA formation by reverse transcriptase-PCR in carrier lymphocyte mRNA, and subcellular localization with dye-labeled fusion constructs. All tests included clinically meaningful controls. The strategy enabled efficient identification of defects in two unclear variants: the p.Asp41His variant showed loss of MMR activity, whereas the compound variant p.Glu605del + p.Val716Met had a defect of expression. This expression defect was significantly stronger than the pathogenic expression reference variant analyzed in parallel, therefore the defect of the compound variant is also pathogenic. Interestingly, the expression defect was caused additively by both of the compound variants, at least one of which is non-pathogenic when occurring by itself. Tests were neutral for p.Leu507Phe and p.Gln689Arg, and the results were consistent with available clinical data. We finally discuss the improved sensitivity and efficiency of the applied strategy and its limitations in analyzing unclear coding MLH1 variants.

  16. Hereditary diffuse gastric cancer and lynch syndromes in a BRCA1/2 negative breast cancer patient.

    Science.gov (United States)

    Njoroge, Scolastica W; Burgess, Kelly R; Cobleigh, Melody A; Alnajar, Hussein H; Gattuso, Paolo; Usha, Lydia

    2017-07-12

    Genetic counseling and testing is recommended for women with a personal and/or family history of breast and other cancers (ovarian, pancreatic, male breast and others). Mutations in the BRCA1 and BRCA2 genes (BRCA1/2) are the most common causes of hereditary breast and ovarian cancer. Additional genetic counseling and testing with a multi-gene panel may be considered in breast cancer patients who tested negative for mutations in these two genes. In about 11% of BRCA1/2-negative patients, further genetic testing reveals pathogenic mutations in other high or moderate cancer risk genes. In 0.2% of cases, an individual may carry pathogenic mutations in more than one high penetrance gene (a double heterozygote). Finding one or more pathogenic mutations is important for cancer prevention in patients and/or their families. Here we present a case of a breast cancer patient who did not have a pathogenic mutation in BRCA1/2 and had a family history of breast and stomach cancers. On an additional multi-gene panel testing, she was found to carry pathogenic mutations in the CDH1 and PMS2 genes, which cause Hereditary Diffuse Gastric Cancer and Lynch syndromes, respectively. To our knowledge, this is the first description of such a double heterozygote. Clinical manifestations, genetics, and management of both syndromes are reviewed, including prophylactic surgery and screening for unaffected family members. Management challenges for a mutation carrier with advanced breast cancer are discussed. Our case supports the clinical utility of additional multi-gene panel testing for breast cancer patients who do not have a pathogenic mutation in BRCA1/2 genes.

  17. Psychological distress in newly diagnosed colorectal cancer patients following microsatellite instability testing for Lynch syndrome on the pathologist's initiative.

    Science.gov (United States)

    Landsbergen, K M; Prins, J B; Brunner, H G; van Duijvendijk, P; Nagengast, F M; van Krieken, J H; Ligtenberg, M; Hoogerbrugge, N

    2012-06-01

    According to the Dutch Guideline on Hereditary Colorectal Cancer published in 2008, patients with recently diagnosed colorectal cancer (CRC) should undergo microsatellite instability (MSI) testing by a pathologist immediately after tumour resection if they are younger than 50 years, or if a second CRC has been diagnosed before the age of 70 years, owing to the high risk of Lynch syndrome (MIPA). The aim of the present MIPAPS study was to investigate general distress and cancer-specific distress following MSI testing. From March 2007 to September 2009, 400 patients who had been tested for MSI after newly diagnosed CRC were recruited from 30 Dutch hospitals. Levels of general distress (SCL-90) and cancer-specific distress (IES) were assessed immediately after MSI result disclosure (T1) and 6 months later (T2). Response rates were 23/77 (30%) in the MSI-positive patients and 58/323 (18%) in the MSI-negative patients. Levels of general distress and cancer-specific distress were moderate. In the MSI-positive group, 27% of the patients had high general distress at T1 versus 18% at T2 (p = 0.5), whereas in the MSI-negative group, these percentage were 14 and 18% (p = 0.6), respectively. At T1 and T2, cancer-specific distress rates in the MSI-positive group and MSI-negative group were 39 versus 27% (p = 0.3) and 38 versus 36% (p = 1.0), respectively. High levels of general distress were correlated with female gender, low social support and high perceived cancer risk. Moderate levels of distress were observed after MSI testing, similar to those found in other patients diagnosed with CRC. Immediately after result disclosure, high cancer-specific distress was observed in 40% of the MSI-positive patients.

  18. Genetic testing for Lynch syndrome in the first year of colorectal cancer: a review of the psychological impact.

    Science.gov (United States)

    Landsbergen, Karin M; Prins, Judith B; Brunner, Han G; Kraaimaat, Floris W; Hoogerbrugge, Nicoline

    2009-01-01

    An increasing number of patients with colorectal cancer (CRC) receive genetic counselling within 1 year after diagnosis. Little is known whether specific subgroups are more vulnerable for genetic testing related distress. A literature review was conducted to identify the psychological impact of CRC in the first year, and the additional impact of genetic testing. The electronic databases of PubMed, PsychInfo, Embase and the Cochrane Library were searched to identify all reports published between January 1997 and October 2007 on the psychological impact of (1) CRC-diagnosis up to 1 year after treatment and of (2) genetic testing for Lynch syndrome in patients with CRC. Studies on the psychological impact of genetic testing in newly diagnosed patient with CRC were not available. Either CRC patients diagnosed several years ago were studied and the focus was also often on the psychological impact of genetic testing prior to DNA-test disclosure. They show that limitations in emotional and social functioning can persist up to 1 year after CRC treatment, especially in those with a stoma or diagnosed before age 60. Female patients and male patients diagnosed before age 50 appear to be more vulnerable to genetic test-related distress. It is well known that being treated for CRC has great impact on psychological functioning. Little is known about the psychological impact during the first year after diagnosis and very little is known about the additional psychological effect of genetic testing for hereditary cancer in this period. We found presumptive evidence that specific subgroups of patients with CRC are more vulnerable for genetic-testing-related distress.

  19. Margaret Fuller, Des femmes en Amérique/ Claudette Fillard, Elizabeth Cady Stanton. Naissance du féminisme américain

    OpenAIRE

    Lacoue-Labarthe, Isabelle

    2013-01-01

    Différents textes de Margaret Fuller et Elizabeth Cady Stanton, deux féministes américaines parfois oubliées de l’historiographie au profit notamment de Susan B. Anthony (dont le nom reste associé à l’amendement qui a accordé, aux États-Unis, le droit de vote aux femmes) ont récemment fait l’objet de traductions en français et d’une édition critique éclairante. Si la lecture parallèle de leurs textes fait apparaître des traits communs entre les deux militantes, parcours et convictions présent...

  20. Supplement Analysis for the Transmission System Vegetation Management Program FEIS (DOE/EIS-0285/SA-104–Lynch Creek Tap to LaGrande-Cowlitz No. 1

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Mark A. [Bonneville Power Administration (BPA), Portland, OR (United States)

    2002-08-21

    Vegetation Management for the Lynch Creek to LaGrande-Cowlitz No. 1. BPA proposes to remove unwanted vegetation along the right-of-way, access roads and around tower structures along the subject transmission line corridor. The right-of-way will be treated using selective and non-selective methods that include hand cutting, mowing and herbicide treatments. Approximately 29 miles of access roads and corridor will be treated. Vegetation management is required for unimpeded operation and maintenance of the subject transmission line. See Section 1 of the attached checklist for a complete description of the proposal.

  1. De onde se vê? Duplicação e dissolução do olhar em Alfred Hitchcock e David Lynch

    Directory of Open Access Journals (Sweden)

    Ulysses Pinheiro

    2015-07-01

    Full Text Available Este artigo compara dois filmes, Janela indiscreta, de Alfred Hitchcock, e Estrada perdida, de David Lynch, com o objetivo de mostrar que eles ilustram duas maneiras distintas de caracterizar o olhar inumano da percepção cinematográfica, tal como ele foi descrito por Gilles Deleuze. Essas duas maneiras distintas não foram discriminadas pelo próprio Deleuze, mas convergem em direção a sua crítica à hermenêutica.

  2. 55,000 yrs of Environmental Change in the Southern Hemisphere: Peat Stratigraphy and Inorganic Geochemistry of Lynch's Crater, NE Queensland, Australia.

    Science.gov (United States)

    Muller, J.; Kylander, M. E.; Wust, R. A.; Weiss, D. J.

    2005-12-01

    This study presents one of the first applications of geochemical proxies to define changes in vegetation, hydrology and atmospheric dust recorded in a peat deposit in the Southern Hemisphere. The Lynch's Crater archive has captured local, regional and global environmental changes and reveals dynamic ecosystem changes as a result of climate shifts over the past 55,000 yrs BP. The 13 m peat record consists of 1.5 m of ombrotrophic peat underlain by a minerotrophic peat. The ombrotrophic section consists of low inorganic content ("ash") and low pH, as expected in of an ombrotrophic environment. The minerotrophic section contains several layers, up to a few cm thick, where abundant sponge spicules, diatom fragments and detrital quartz are indicative of high algal and protista productivity. These layers are characterised by high (up to 50%) ash, indicating persistent flooding of the peat deposits of Lynch's Crater and signalling periods of change in precipitation in North Queensland, Australia. Geochemical data are used to differentiate between climatic episodes associated with flooding events and internal and external atmospheric dust fluxes. Lead isotopes with lithogenic and chalcophile elements tell us that two distinctive sources are prevalent in the Lynch's Crater record. Most of the inorganic fractions of the deposits have the same geochemical signatures as the rocks and sediments of the crater wall, with low As concentrations, high Al, Ti and Sc concentrations and a more radiogenic Pb isotope signature. Influence from long-range dust is distinguished in the lower sections of the core (~35,000-55,000 cal yrs BP) where increases in As concentrations and less radiogenic Pb isotopes are found. Leading up to the Holocene (~35,000-10,000) the influence of increased dust influx becomes more significant (increasing lithogenics, chalcophiles and ash content) and where possible long-range sources are still active, but diluted by a prevailing dominance of the local sources

  3. A putative Lynch syndrome family carrying MSH2 and MSH6 variants of uncertain significance-functional analysis reveals the pathogenic one

    DEFF Research Database (Denmark)

    Kantelinen, Jukka; Hansen, Thomas V O; Kansikas, Minttu;

    2011-01-01

    Inherited pathogenic mutations in the mismatch repair (MMR) genes, MSH2, MLH1, MSH6, and PMS2 predispose to Lynch syndrome (LS). However, the finding of a variant or variants of uncertain significance (VUS) in affected family members complicates the risk assessment. Here, we describe a putative L...... identified VUS before predictive gene testing and genetic counseling are offered to a family.......Inherited pathogenic mutations in the mismatch repair (MMR) genes, MSH2, MLH1, MSH6, and PMS2 predispose to Lynch syndrome (LS). However, the finding of a variant or variants of uncertain significance (VUS) in affected family members complicates the risk assessment. Here, we describe a putative LS...... family carrying VUS in both MSH2 (c.2768T>A, p.Val923Glu) and MSH6 (c.3563G>A, p.Ser1188Asn). Two colorectal cancer (CRC) patients were studied for mutations and identified as carriers of both variants. In spite of a relatively high mean age of cancer onset (59.5 years) in the family, many CRC patients...

  4. 改良 B-Lynch 缝合术在剖宫产术中宫缩乏力性出血的应用%Application of improved B-Lynch sutura in hemorrhage caused by uterine inertia during the ce-sarean section

    Institute of Scientific and Technical Information of China (English)

    白琳

    2014-01-01

    Objective To investigate the application methods and clinical effect of improved B-Lynch sutura on hemorrhage caused by uterine inertia during the cesarean section. Methods A retro-spective analysis was performed on the clinical data of 72 patients with hemorrhage caused by uterine in-ertia during the cesarean section,who were treated by improved B-Lynch sutura in the first people’s hos-pital of Shangqiu from April 2008 to June 2013. Results The hemorrhage dosage during operation of the 72 patients was 600 - 2300 ml,all of the patients were stanched effectively,the effective rate was 100%and there was no hemorrhagic shock occured during the operation,7 cases were taken transfusion for 400 - 800 ml,no one was cut the uterus because of hemorrhage out-of-control. The uterus wounds of the patients healed well and there was no complication of rehaemorrhagia,infection,intrauterine adhesion or endometriosis occur. Follow-up visited for 7 - 14 months after the patients left the hospital,found their lochia was regular,when reviewed the patients by B ultrasound 42 days after the operation showed that, their involution of uterus was good. Conclusions The B-Lynch sutura is easy to handle,dispense with special instrument and high technical requirements,it has the characteristics of rapid,valid and definite when salvaging the patients with massive haemorrhage caused by uterine inertia during the cesarean sec-tion,besides,it is also beneficial to uterus recovery and suitable for primary hospital to use.%目的:探讨改良 B-Lynch 缝扎术治疗剖宫产术中宫缩乏力性产后出血的应用方法及临床效果。方法回顾性分析2008年4月至2013年6月间商丘市第一人民医院采用改良式 B-Lynch 缝合术治疗的72例剖宫产术中宫缩乏力性产后出血患者的临床资料。结果72例患者术中出血600~2300 ml,均有效止血,有效率100%,无术中失血性休克发生,7例患者输血400~800 ml,无因出血无法控制行子宫

  5. Aging in cultural context and as narrative process: conceptual foundations of the anthropology of aging as reflected in the works of Margaret Clark and Sharon Kaufman.

    Science.gov (United States)

    Perkinson, Margaret A; Solimeo, Samantha L

    2014-02-01

    Although the discipline of anthropology has much to contribute to the understanding of the nature and experience of aging, it is a relative latecomer to gerontology. After briefly discussing why this is the case, the authors discuss the contributions of two anthropologists who brought a substantive anthropological voice to gerontological discussion of aging. Examining the "ancestral roots" of the anthropology of aging, we spotlight the intellectual heritage of Margaret Clark, arguably the "mother" of this anthropological subfield, and that of Sharon Kaufman, her student, colleague, and a pioneer in her own right. Clark and Anderson's Culture and aging: an anthropological study of older Americans (1967; Springfield, IL: Charles C. Thomas) remains a touchstone for the concept of situated aging. This examination of value orientations and mental health of older San Franciscans is foundational for understanding aging as an interactive, socially embedded process that is adapted to specific sociocultural contexts. Research and therapies grounded in narrativity and meaning benefit from Sharon Kaufman's The ageless self: sources of meaning in late life (1986; Madison, WI: University of Wisconsin Press), which articulated narrative thinking as a conduit for understanding, performing, and constructing identity and meaning. Kaufman's work has ongoing relevance to gerontological research on embodiment, chronic illness, and later life social transitions. Their research has continued relevance to contemporary gerontological scholarship and practice, signaling both prevailing and emergent agendas for anthropologically informed gerontology.

  6. Intertekstinis Margaretos Atwood romano Tarnaitės pasakojimas skaitymas | An Intertextual Reading of Margaret Atwood’s The Handmaid’s Tale

    Directory of Open Access Journals (Sweden)

    Rūta Šlapkauskaitė

    2004-01-01

    Full Text Available Since its publication in 1985, Margaret Atwood’s dystopia The Handmaid’s Tale has prominently secured its place among the most widely read novels of Canadian literature. The present article offers a reading of Atwood’s The Handmaid’s Tale as a narrative built on intertextual relationships with other texts, which are directly or implicitly referred to in the novel. This analysis of the novel emphasizes reading as a dynamic semiotic process and employs Gérard Genette’s notion of transtextuality to look into the narrative’s semantic field from the perspective of its paratextual, intertextual and metatextual relationships. While focusing on the Bible as the major intertext that structures the semantic space of Atwood’s narrative, this intertextual reading of The Handmaid’s Tale also looks at the ways in which the biblical context of Atwood’s novel correlates with the paratexts of Jonathan Swift’s essay A Modest Proposal and sufi philosophy to delineate the dominant strategies of the reading and interpreting of Atwood’s text. Finally, the article analyzes the metatextual level of Atwood’s novel and points out the ways in which the writer ironizes the intertextual nature of her own text and fictionalizes its intertexts, thereby suggesting the impossibility of narrative and interpretative closure.

  7. Children of Oryx, Children of Crake, Children of Men: Redefining the Post/Transhuman in Margaret Atwood’s “ustopian” MaddAddam Trilogy

    Directory of Open Access Journals (Sweden)

    Eduardo Marks de Marques

    2016-04-01

    Full Text Available Um dos principais pilares do pensamento pós-humano e transumano é o uso da tecnologia como meio de melhorar a vida humana ao auxiliar na superação de falhas e limitações do corpo biológico. O efeito de tais tendências tem sido central ao desenvolvimento de romances distópicos contemporâneos, de terceira virada, em inglês, publicados nos últimos trinta anos, aproximadamente. Entretanto, um aspecto importante de tais narrativas também é seu rol de características transgressoras, que as distanciam de seus equivalentes modernos, de segunda virada. O presente artigo almeja discutir o quão transgressoras são as ideias de distopia e transumanismo que formam a base da trilogia MaddAddam, de Margaret Atwood, essencialmente discutindo o que encontra-se no núcleo da condição humana.

  8. Bears in Eden, or, this is not the garden you're looking for: Margaret Cavendish, Robert Hooke and the limits of natural philosophy.

    Science.gov (United States)

    Lawson, Ian

    2015-12-01

    This paper investigates Margaret Cavendish's characterization of experimental philosophers as hybrids of bears and men in her 1666 story The Description of a New World, Called the Blazing World. By associating experimental philosophers, in particular Robert Hooke and his microscope, with animals familiar to her readers from the sport of bear-baiting, Cavendish constructed an identity for the fellows of the Royal Society of London quite unlike that which they imagined for themselves. Recent scholarship has illustrated well how Cavendish's opposition to experimental philosophy is linked to her different natural-philosophical, political and anthropological ideas. My contribution to this literature is to examine the meanings both of bears in early modern England and of microscopes in experimental rhetoric, in order to illustrate the connection that Cavendish implies between the two. She parodied Hooke's idea that his microscope extended his limited human senses, and mocked his aim that by so doing he could produce useful knowledge. The bear-men reflect inhuman ambition and provide a caution against ignoring both the order of English society and the place of humans in nature.

  9. Truncation of the MSH2 C-terminal 60 amino acids disrupts effective DNA mismatch repair and is causative for Lynch syndrome.

    Science.gov (United States)

    Wielders, Eva; Delzenne-Goette, Elly; Dekker, Rob; van der Valk, Martin; Te Riele, Hein

    2017-04-01

    Missense variants of DNA mismatch repair (MMR) genes pose a problem in clinical genetics as long as they cannot unambiguously be assigned as the cause of Lynch syndrome (LS). To study such variants of uncertain clinical significance, we have developed a functional assay based on direct measurement of MMR activity in mouse embryonic stem cells expressing mutant protein from the endogenous alleles. We have applied this protocol to a specific truncation mutant of MSH2 that removes 60 C-terminal amino acids and has been found in suspected LS families. We show that the stability of the MSH2/MSH6 heterodimer is severely perturbed, causing attenuated MMR in in vitro assays and cancer predisposition in mice. This mutation can therefore unambiguously be considered as deleterious and causative for LS.

  10. Tumour spectrum of non-polyposis colorectal cancer (Lynch syndrome) on the island of Tenerife and influence of insularity on the clinical manifestations.

    Science.gov (United States)

    Medina-Arana, V; Barrios, Y; Fernández-Peralta, A; Jiménez, A; Salido, E; González, F; González-Aguilera, J J

    2004-02-01

    Colorectal cancer is a complex disease from a genetic point of view because both genetic and environmental factors interact in its development. Only familial adenomatous polyposis (FAP) follows mendelian genetics, in that mutations of the APC gene lead to development of the tumours. Lynch syndrome is the most frequent form of hereditary colorectal cancer and appears to be associated with other types of extracolonic cancers. The genetic basis has been established as a defect in DNA mismatch repair genes, and there is genetic heterogeneity due to the involvement of several genes in this system. Germinal mutations in these genes predispose to appearance of the syndrome. The aim of this study is to describe the tumoral spectrum of 10 families, comprising a total of 488 individuals, from the island of Tenerife (Canary Islands) and to assess whether the geographical isolation of this population has changed any features of the tumoral spectrum of the syndrome in comparison with studies that cover larger geographical areas with more genetic exchange. From our results we can conclude that the genetic drift and consanguinity in this population with a demographic history of isolation did not significantly alter the tumoral spectrum of the syndrome. Our data confirm that families affected by Lynch syndrome are a high-risk population and should be closely monitored, since their careful supervision has been shown to be useful in preventing cancer. We also emphasize the importance of developing a complete family history that permits these families to be identified together with a mutational screening of DNA mismatch repair genes (mainly MLH1 and MSH2 genes) with the aim of a possible identification of members of a family that should be carefully monitored (the carriers of germline mutations in these genes), whereas the remaining members, originally, are no more at risk than the general population.

  11. David Lynch - Dark Splendor. Raum Bilder Klang, hrg. von Werner Spies, Ostfildern 2009; See this Sound. Versprechungen von Bild und Ton, hrg. von Cosima Rainer u.a., Köln 2009

    Directory of Open Access Journals (Sweden)

    Sarah Mauksch

    2010-09-01

    Full Text Available Das Max Ernst Museum in Brühl und das Lentos Kunstmuseum in Linz haben jüngst zwei Ausstellungskataloge herausgebracht, denen eine jeweils bemerkenswerte Ausstellung vorausging.Der Regisseur David Lynch wurde vor allem durch seine beeindruckenden Spielfilme wie Lost Highway, Mulholland Drive, Blue Velvet oder durch die Serie Twin Peaks aus den 90er Jahren bekannt. Die Ausstellung David Lynch – Dark Splendor. Raum Bilder Klang enthüllt eine Seite des Kultregisseurs, die vielen Filmliebhabern noch unentdeckt geblieben sein könnte. Brühl zeigt hier erstmals in Deutschland eine Sammlung, die sich nur mit dem bildnerischen Schaffen des Künstlers befasst.

  12. «We have ceased to be a nation in retreat». Margaret Thatcher e gli usi strategici del conflitto

    Directory of Open Access Journals (Sweden)

    Lidia De Michelis

    2015-03-01

    Full Text Available This essay explores Margaret Thatcher’s political agency and leadership style in terms of her reliance on discursive and media strategies which thrived on the “confusion” of gender stereotypes and her ability to play with multiple, long-established archetypes of women in power, characterized by violent and aggressive femininity. Thatcher’s frequent self-projection as a “masculine” character, the “honorary man” of British politics, and her special grip on British public opinion and fantasies, were never disjointed from her ability to don, exploit, subvert and redirect “motherly’ (or at least “womanly” performances at will, in order to serve her political agenda. Focusing on her strategic deployment of a rhetoric and discourses of aggression, divisiveness, conflict and war, the essay highlights Thatcher’s ability to re-create and keep alive the idea of a national community always under siege, where extraordinary economic, disciplinary and defence measure were required in order to resist and overcome domestic and foreign “enemies”. The Falklands War will be taken as case study, for it provides an outstanding example of Thatcher’s powerful revision of female political authority against the backdrop of the conventionally masculine, heroic imaginary of war. Her masterly and coterminous performances as war leader and “super-mother” of the nation allowed for a complex and hybrid self-projection which still acts as an empowering model whose disciplinary subtext entails a nostalgic investment in imperial national history.

  13. “As Canadian as possible under the circumstances": how girls grow up canadian in Margaret Awood’s The Robber Bride « Aussi canadien que possible dans ces circonstances » : comment les jeunes filles sont élevées en canadiennes dans La Voleuse d’hommes de Margaret Atwood

    Directory of Open Access Journals (Sweden)

    Ellen McCarthy

    2009-10-01

    Full Text Available Cet article explore comment Margaret Atwood, dans La Voleuse d’hommes (The Robber Bride, 1993, élargit l’éventail des possibilités existantes pour concevoir l’identité nationale anglo-canadienne. Il se concentre sur la façon dont le roman réaborde et reformule certaines des questions sur l’identité canadienne qui sont posées avec insistance dans les premiers récits de fiction et essais critiques d’Atwood. L’article s’intéresse, en particulier, à la manière dont les récits d’évolution personnelle s’entrecroisent avec les discours sur l’identité féminine et canadienne dans La Voleuse d’hommes. Il s’agit d’examiner comment les trajectoires d’évolution personnelle explorées dans le roman attirent l’attention sur la relation complexe entre narration et identité, et d’expliquer comment progrès et évolution, dans les romans, sont influencés ou déterminés par un positionnement politique identitaire nationaliste spécifiquement féministe et canadien.

  14. Evaluating the performance of clinical criteria for predicting mismatch repair gene mutations in Lynch syndrome: a comprehensive analysis of 3,671 families.

    Science.gov (United States)

    Steinke, Verena; Holzapfel, Stefanie; Loeffler, Markus; Holinski-Feder, Elke; Morak, Monika; Schackert, Hans K; Görgens, Heike; Pox, Christian; Royer-Pokora, Brigitte; von Knebel-Doeberitz, Magnus; Büttner, Reinhard; Propping, Peter; Engel, Christoph

    2014-07-01

    Carriers of mismatch repair (MMR) gene mutations have a high lifetime risk for colorectal and endometrial cancers, as well as other malignancies. As mutation analysis to detect these patients is expensive and time-consuming, clinical criteria and tumor-tissue analysis are widely used as pre-screening methods. The aim of our study was to evaluate the performance of commonly applied clinical criteria (the Amsterdam I and II Criteria, and the original and revised Bethesda Guidelines) and the results of tumor-tissue analysis in predicting MMR gene mutations. We analyzed 3,671 families from the German HNPCC Registry and divided them into nine mutually exclusive groups with different clinical criteria. A total of 680 families (18.5%) were found to have a pathogenic MMR gene mutation. Among all 1,284 families with microsatellite instability-high (MSI-H) colorectal cancer, the overall mutation detection rate was 53.0%. Mutation frequencies and their distribution between the four MMR genes differed significantly between clinical groups (p small-bowel cancer (p small-bowel cancer were clinically relevant predictors for Lynch syndrome. © 2013 UICC.

  15. A Review of James Lynch Multicultural Education Ideology%詹姆斯·林奇多元文化教育思想及评析

    Institute of Scientific and Technical Information of China (English)

    廖明艳

    2016-01-01

    当今世界各国都面临多元文化的冲击,各国教育工作者也不遗余力地进行着多元文化教育的研究,詹姆斯·林奇在这一方面做出了自己的贡献。他的多元文化教育思想主要体现在其多元文化课程理论及全球多元文化教育思想之中,其最大特点是从全球化的观点审视多元文化教育。%Today ,all countries in the world are being affected by multi-cultures ,the educators all over the world have spared no effort to study the multicultural education .James Lynch has made his own contribution to this aspect .His multicultural education ideology reflects on his multicultural curriculum theory ,the thought of global multicultural education and the civic education .And its characteristic is that he examines the multicultural education from the perspective of globalization .

  16. Hea energia festival / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2006-01-01

    Augusti tantsufestivali 2005 lavastustest - Rasmus Ölme "Rasmus Kosmos", Paz Rojo "Basic Dance", Eddie Laddi "Sawn-off Scarface", Krõõt Juuraku, Raido Mägi, Mart Kangro ja Merle Saarva ning saksofonist Ursula Saali ühisprojekt "Positsioonid", "ZUGA müüt ja tegelikkus", Xavier Le Roy "Projekt" ja Jo Str̤mgreni "The Hospidal"

  17. Hea energia festival / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2006-01-01

    Augusti tantsufestivali 2005 lavastustest - Rasmus Ölme "Rasmus Kosmos", Paz Rojo "Basic Dance", Eddie Laddi "Sawn-off Scarface", Krõõt Juuraku, Raido Mägi, Mart Kangro ja Merle Saarva ning saksofonist Ursula Saali ühisprojekt "Positsioonid", "ZUGA müüt ja tegelikkus", Xavier Le Roy "Projekt" ja Jo Str̤mgreni "The Hospidal"

  18. Experience of B-Lynch suture in 8 cases of postpartum hemorrhage%B -Lynch缝合术治疗8例剖宫产后出血体会

    Institute of Scientific and Technical Information of China (English)

    杨春霞

    2015-01-01

    Objective To investigate the clinical effect of B-Lynch suture in the treatment of postpartum hemorrhage.Methods The data of medical records of 8 patients with postpartum hemorrhage treated by B-Lynch suture were retrospectively analyzed in our hospital from January 2012 to 2015 March.Results Totally 8 cases of patients were successful hemostasis, uterus preserved, no 1 case reoperation or hys-terectomy because of poor blood circulation or rebleeding, no related complications occurred, involution of uterus, menstruation time without ex-ception.Conclusion B-Lynch suture is an effective surgical hemostasis method for the treatment of cesarean section uterine bleeding caused by uterine contraction fatigae, and is simple and feasible, especially for the basic hospital.%目的:探讨B-Lynch缝合术治疗剖宫产后出血的效果。方法对8例剖宫产后出血患者采用B-Lynch缝合术治疗,回顾性分析患者的病历资料。结果8例患者均经B-Lynch缝合术成功止血,无1例因血液循环不良或再出血手术或子宫切除。子宫复旧、月经复潮时间无异常。结论剖宫产后子宫收缩乏力性出血药物治疗无效时,B-Lynch缝合术操作简单易行,止血效果可靠,尤其适合在基层医院开展。

  19. Population-Based Lynch Syndrome Screening by Microsatellite Instability in Patients ≤50: Prevalence, Testing Determinants, and Result Availability Prior to Colon Surgery.

    Science.gov (United States)

    Karlitz, Jordan J; Hsieh, Mei-Chin; Liu, Yong; Blanton, Christine; Schmidt, Beth; Jessup, J Milburn; Wu, Xiao-Cheng; Chen, Vivien W

    2015-07-01

    As there are no US population-based studies examining Lynch syndrome (LS) screening frequency by microsatellite instability (MSI) and immunohistochemistry (IHC), we seek to quantitate statewide rates in patients aged ≤50 years using data from a Centers for Disease Control and Prevention-funded Comparative Effectiveness Research (CER) project and identify factors associated with testing. Screening rates in this young, high-risk population may provide a best-case scenario as older patients, potentially deemed lower risk, may undergo testing less frequently. We also seek to determine how frequently MSI/IHC results are available preoperatively, as this may assist with decisions regarding colonic resection extent. Data from all Louisiana colorectal cancer (CRC) patients aged ≤50 years diagnosed in 2011 were obtained from the Louisiana Tumor Registry CER project. Registry researchers and physicians analyzed data, including pathology and MSI/IHC. Of the 2,427 statewide all-age CRC patients, there were 274 patients aged ≤50 years, representing health care at 61 distinct facilities. MSI and/or IHC were performed in 23.0% of patients. Testing-associated factors included CRC family history (Plocation (P<0.0370), and care at comprehensive cancer centers (P<0.0020) but not synchronous/metachronous CRC or MSI-like histology. Public hospital screening was disproportionately low (P<0.0217). Of those tested, MSI and/or IHC was abnormal in 21.7%. Of those with abnormal IHC, staining patterns were consistent with LS in 87.5%. MSI/IHC results were available preoperatively in 16.9% of cases. Despite frequently abnormal MSI/IHC results, LS screening in young, high-risk patients is low. Provider education and disparities in access to specialized services, particularly in underserved populations, are possible contributors. MSI/IHC results are infrequently available preoperatively.

  20. A morphological, isoenzymatic and behavioural study of ten populations of Anopheles(Nyssorhynchus albitarsis Lynch-Arribalzaga, 1878 (Diptera: culicidae including from the type-locality - Baradero, Argentina

    Directory of Open Access Journals (Sweden)

    Maria Goreti Rosa-Freitas

    1990-09-01

    Full Text Available Anopheles (Nyssorhynchus albitarsis Lynch-Arribalzaga, 1878 shows morphological and behavioural variations which results in it being sometimes considered as a major malaria vector and at other times as playing no important role in epidemiology. With the aim of clarifying the taxonomy of the species, comparative morphological and isoenzymatic studies were made in populations from the type-locality, Baradero, Argentina and from 9 different localities inBrazil. Morphological studies consisted of the observation of eggs in scanning electron microscopy, of complete chaetotaxy of larvae and pupae and of the detailed drawing of male and female adults. Only Guajara-Mirim and Rio Branco populations, described previously as Anopheles deaneorum sp.n., showed morphological differences. Isoenzymes were studied using 4th instar larvae homogenate and agarosegel electrophoresis. Eleven enzymatic loci were analyzed. By calculation of Nei's Genetic Distance (D, the populations could be separated into 5 groups: iBaradero, iiMarajo, iiiBoa Vista, ivAngra, Itaguai and Paraipaba and vGuajara-Mirim and Rio Branco. These groups belong to 2 major clusters called I and II, separated by D = 0.345. In the I cluster are groups i, ii and iii and in II clusteriv and v. In I, D=0.246 separates i and ii from iii, while i is separated by D =0.181 from ii. In II, D = 0.223 between iv and v. Only the population of group vcould be distinguished morphologically from the others, leading to the description of an independent species An. deaneorum.

  1. Lynch syndrome-associated colorectal carcinoma: frequent involvement of the left colon and rectum and late-onset presentation supports a universal screening approach.

    Science.gov (United States)

    Hartman, Douglas J; Brand, Randall E; Hu, Huankai; Bahary, Nathan; Dudley, Beth; Chiosea, Simon I; Nikiforova, Marina N; Pai, Reetesh K

    2013-11-01

    The optimal strategy for screening patients with colorectal carcinoma for Lynch syndrome (LS) is a subject of continued debate in the literature with some advocating universal screening while others arguing for selective screening. We evaluated 1292 colorectal carcinomas for DNA mismatch repair protein abnormalities and identified 150 (11.6%) tumors demonstrating high-levels of microsatellite instability (MSI-H). MSI-H colorectal carcinomas were divided into sporadic (112/1292, 8.7%) and LS/probable LS-associated (38/1292, 2.9%) groups based on BRAF V600E mutation, MLH1 promoter hypermethylation, cancer history, and germline mismatch repair gene mutation. All MSI-H colorectal carcinomas were analyzed for grade, location, and tumor histology. The utility of the revised Bethesda guidelines and published predictive pathology models for MSI-H colorectal carcinomas (PREDICT and MSPath) were evaluated. Left-sided MSI-H colorectal carcinomas were more frequently associated with LS compared with right-sided MSI-H colorectal carcinomas (12/21, 57% versus 26/129, 20%, P = .0008). There was no significant difference in histology between sporadic MSI-H and LS/probable LS-associated colorectal carcinomas except for a slightly higher proportion of sporadic MSI-H tumors demonstrating tumor-infiltrating lymphocytes (81% versus 61%, P = .015). Neither pathology predictive model identified all LS-associated colorectal carcinomas (PREDICT: 33/38, 87%; MSPath: 35/38, 92%). 12/117 (10%) MSI-H colorectal carcinomas identified in patients >60 years were LS/probable LS-associated. Our results demonstrate that models of predicting MSI-H fail to identify LS-associated colorectal carcinoma given their reliance on right-sided location. A significant proportion (32%) of LS-associated colorectal carcinoma is identified in patients >60 years. Finally, our results demonstrate similar morphologic features between LS-associated and sporadic MSI-H colorectal carcinomas.

  2. Isolated Loss of PMS2 Immunohistochemical Expression is Frequently Caused by Heterogenous MLH1 Promoter Hypermethylation in Lynch Syndrome Screening for Endometrial Cancer Patients.

    Science.gov (United States)

    Kato, Aya; Sato, Naoki; Sugawara, Tae; Takahashi, Kazue; Kito, Masahiko; Makino, Kenichi; Sato, Toshiharu; Shimizu, Dai; Shirasawa, Hiromistu; Miura, Hiroshi; Sato, Wataru; Kumazawa, Yukiyo; Sato, Akira; Kumagai, Jin; Terada, Yukihiro

    2016-06-01

    Lynch syndrome (LS) is an autosomal-dominant inherited disorder mainly caused by a germline mutation in the DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6, and PMS2) and is associated with increased risk for various cancers, particularly colorectal cancer and endometrial cancer (EC). Women with LS account for 2% to 6% of EC patients; it is clinically important to identify LS in such individuals for predicting and/or preventing additional LS-associated cancers. PMS2 germline mutation (PMS2-LS) is the rarest contribution to LS etiology among the 4 LS-associated MMR germline mutations, and its detection is complicated. Therefore, prudent screening for PMS2-LS is important as it leads to an efficient LS identification strategy. Immunohistochemistry is recommended as a screening method for LS in EC. Isolated loss of PMS2 (IL-PMS2) expression is caused not only by PMS2-LS but also by MLH1 germline mutation or MLH1 promoter hypermethylation (MLH-PHM). This study aimed to determine the association between MLH1-PHM and IL-PMS2 to avoid inappropriate genetic analysis. We performed MLH1 methylation analysis and MLH1/PMS2 germline mutation testing on the IL-PMS2 cases. By performing MMR-immunohistochemistry on 360 unselected ECs, we could select 8 (2.2%) cases as IL-PMS2. Heterogenous MLH1 staining and MLH1-PHM were detected in 4 of 8 (50%) IL-PMS2 tumors. Of the 5 IL-PMS2 patients who underwent genetic analysis, 1 had PMS2 germline mutation with normal MLH1 expression (without MLH1-PHM), and no MLH1 germline mutation was detected. We suggest that MLH1 promoter methylation analysis for IL-PMS2 EC should be performed to exclude sporadic cases before further PMS2 genetic testing.

  3. The making of a Chinese head of the WHO: a study of the media discourse on Margaret Chan's contest for the WHO director-generalship and its implications for the collective memory of SARS.

    Science.gov (United States)

    Yin, Chan Wai; Yun, Ma Shu

    2009-01-01

    In 2003, Margaret Chan Fung Fu-chun, former Director of Health of the Hong Kong government, was criticized for her unsatisfactory performance in handling the SARS outbreak. But three years later, she was celebrated for her success in the contest for the WHO director-generalship. How was she transformed from an incompetent official into an "honor winner" for China and Hong Kong? In what context was this made possible? How was the collective memory about Chan recalled and reconstructed? This article tackles these questions by reviewing relevant reportage and commentary in major local (Hong Kong), national (China), and international media. It maps the political context of the media discourse and explores the construction of a collective past to foster national cohesion in postcolonial Hong Kong.

  4. An Maslow's Interpretation of Margaret in The Lady of the Camellias%《茶花女》中玛格丽特形象的马斯洛式解读

    Institute of Scientific and Technical Information of China (English)

    付妍

    2015-01-01

    The French writer Alexandre Dumas Jr ’ s The Lady of the Camellias has successfully created a charac-ter, Margaret, an upper class prostitutes in the world literature history .Margaret’ s tragic fate has also attracted atten-tions of many critics .This paper uses Maslow's hierarchy of needs to analyze the heroine ’ s psychological process along with development of her fate:in order to meet physiological and safety needs , Margaret unwillingly became a prosti-tute.She pursued ardently true love due to the needs of belongingness and love .She finally chose to sacrifice herself in a strong sense of self-esteem.At the end, the heroine gained dignity , transforming from a“cheap”prostitute to a“noble”Camellias Lady .%法国作家小仲马创作的《茶花女》成功塑造了玛格丽特这个世界文学画廊中闪耀夺目的上流社会妓女形象,其悲剧的命运也成为评论者关注的焦点。本文运用马斯洛需要层次理论进行解读,重点分析女主人公命运发展的心理历程:玛格丽特为满足生理和安全需要而不幸落入风尘,因归属与爱的需要而热烈追寻真爱,最后在强烈的自尊需要推动下选择牺牲涅槃,终于获得崇高的尊严,完成了从“下贱”妓女到“高尚”茶花女的华丽蜕变。

  5. Evidence for classification of c.1852_1853AA>GC in MLH1 as a neutral variant for Lynch syndrome

    Directory of Open Access Journals (Sweden)

    Llor Xavier

    2011-01-01

    Full Text Available Abstract Background Lynch syndrome (LS is an autosomal dominant inherited cancer syndrome characterized by early onset cancers of the colorectum, endometrium and other tumours. A significant proportion of DNA variants in LS patients are unclassified. Reports on the pathogenicity of the c.1852_1853AA>GC (p.Lys618Ala variant of the MLH1 gene are conflicting. In this study, we provide new evidence indicating that this variant has no significant implications for LS. Methods The following approach was used to assess the clinical significance of the p.Lys618Ala variant: frequency in a control population, case-control comparison, co-occurrence of the p.Lys618Ala variant with a pathogenic mutation, co-segregation with the disease and microsatellite instability in tumours from carriers of the variant. We genotyped p.Lys618Ala in 1034 individuals (373 sporadic colorectal cancer [CRC] patients, 250 index subjects from families suspected of having LS [revised Bethesda guidelines] and 411 controls. Three well-characterized LS families that fulfilled the Amsterdam II Criteria and consisted of members with the p.Lys618Ala variant were included to assess co-occurrence and co-segregation. A subset of colorectal tumour DNA samples from 17 patients carrying the p.Lys618Ala variant was screened for microsatellite instability using five mononucleotide markers. Results Twenty-seven individuals were heterozygous for the p.Lys618Ala variant; nine had sporadic CRC (2.41%, seven were suspected of having hereditary CRC (2.8% and 11 were controls (2.68%. There were no significant associations in the case-control and case-case studies. The p.Lys618Ala variant was co-existent with pathogenic mutations in two unrelated LS families. In one family, the allele distribution of the pathogenic and unclassified variant was in trans, in the other family the pathogenic variant was detected in the MSH6 gene and only the deleterious variant co-segregated with the disease in both

  6. ISOLDE PH team, from left to right: Jennifer Weterings (user support), Susanne Kreim (research fellow), Marek Pfützner (scientific associate), Maria Garcia Borge (team leader), Elisa Rapisarda (research fellow) , Magdalena Kowalska (physics coordinator), Jan Kurcewicz (applied fellow), Monika Stachura (applied fellow). Not in the photo: Kara Lynch (PhD student).

    CERN Multimedia

    Visual Media Office

    2013-01-01

    ISOLDE PH team, from left to right: Jennifer Weterings (user support), Susanne Kreim (research fellow), Marek Pfützner (scientific associate), Maria Garcia Borge (team leader), Elisa Rapisarda (research fellow) , Magdalena Kowalska (physics coordinator), Jan Kurcewicz (applied fellow), Monika Stachura (applied fellow). Not in the photo: Kara Lynch (PhD student).

  7. Genetics Home Reference: Lynch syndrome

    Science.gov (United States)

    ... in preparation for cell division (a process called DNA replication ). Mutations in any of these genes prevent the proper repair of DNA replication mistakes. As the abnormal cells continue to divide, ...

  8. Comment Hollywood figure l’intériorité dans les films « hollywoodiens » de David Lynch, Lost Highway (1997, Mulholland Dr. (2001 et Inland Empire (2006

    Directory of Open Access Journals (Sweden)

    David ROCHE

    2011-09-01

    Full Text Available L’article prend comme point de départ les travaux de Zachary Baqué et vise à montrer, à travers une étude diachronique, que les films hollywoodiens de Lynch ne le sont pas uniquement par leur représentation satirique d’un système corrompu qui compromet les ambitions qu’il suscite, ni même par la façon dont il retravaille les conventions génériques et narratives propres au cinéma hollywoodien. Hollywood est une présence à la fois horizontale et verticale, physique et abstraite, réelle et imaginaire, qui renvoie à la ville, au système, au cinéma et au rêve, si bien que la satire, la topographie, les motifs visuels parfois clichés et les références filmiques sont intimement liés en une expression de la subjectivité et de l’intérioritéThe article takes Zachary Baqué’s study of Los Angeles in the films of David Lynch as a starting point to explore David Lynch’s Hollywood movies. The author contends that the films offer more than a satirical representation of a corrupt, unhealthy system which threatens dreams and artistic creativity, or a parodic play on Hollywood genre and narrative conventions. Rather, Hollywood is a character, a presence, revealed as both horizontal and vertical, physical and abstract, evoking the city, the studio system, cinema and dreams, so that the satire, the visual motifs and clichés and the topography of Hollywood, and the references to Hollywood films, constitute a complex fabric of subjectivity and interiority.

  9. 论《神谕女士》中的文体戏仿与女性主体意识%Parody of Genre and Subject Consciousness of Female in Margaret Atwood's Lady Oracle

    Institute of Scientific and Technical Information of China (English)

    李娟

    2015-01-01

    Lady Oracle is one of the representative works of Margaret Atwood who is a famous Canadian writer of contemporary English literature. The heroine of the novel Joan with complex life experience is a Gothic novelist and places her hopes and dreams on writing Gothic novels. Lady Oracle is a parody of Gothic novel,and it shows obvious post-modern characteristics such as multiple subjectivity and complexity of the feminine consciousness in a series of self-images.%《神谕女士》是加拿大当代作家阿特伍德的代表作品之一,这部小说在文体上戏仿哥特小说,同时体现出对女性主体意识复杂性的思考。女主人公琼成长经历曲折,以写作哥特小说来寄托梦想,哥特小说文体在作品中形成了书中之书的叙事模式。在琼所呈现出的一系列多形态的、不同的自我形象中,可以看出阿特伍德在写作中对多元的、复数的主体的解放。由此,《神谕女士》显现出明显的后现代艺术特征。

  10. The Comparison between Rawls and Margaret's Justice:On the Significance of Decent Society Theory to China's System Construction%罗尔斯与马格利特正义观比较--兼论正派社会理论对中国制度建设之意义

    Institute of Scientific and Technical Information of China (English)

    阳鸣

    2014-01-01

    In the field of justice theory,Rawls is the synthesizer,any scholars present their justice theo-ry can steer clear of Rawls's justice theory.From “decent”and “no shame”Angle,Margaret states his distinctive justice theory,and be called the most successful justice theorist after Rawls.Rawls and Margaret's justice theory formation,with their background closely related,Rawls tries to through the distribution to achieve justice,Margaret focus on “decent”and “no shame”justice order construction. In the rapid development of social material in China today,Margaret's decent society theory to the re-form in China has more significance.%正义一直被视为理想政治秩序的基石,从古至今,思想家对正义展开无数探讨,罗尔斯无疑是正义理论领域的集大成者,任何学者在阐述自己的正义理论时都无法绕开罗尔斯的正义理论。而马格利特却从“正派”和“不羞辱”角度提出了自己特点鲜明的正义理论,并被称为罗尔斯之后最成功的正义理论家。罗尔斯和马格利特正义理论的形成,跟各自的时代背景紧密相关,罗尔斯试图通过物质分配去实现正义,马格利特却着力于“正派”、“不羞辱”的正义秩序构建。在物质社会迅猛发展的当下中国,马格利特的正派社会理论对中国之改革有着更大的指导意义。

  11. Identification of individuals at risk for Lynch syndrome using targeted evaluations and genetic testing: National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer joint practice guideline.

    Science.gov (United States)

    Weissman, Scott M; Burt, Randall; Church, James; Erdman, Steve; Hampel, Heather; Holter, Spring; Jasperson, Kory; Kalady, Matt F; Haidle, Joy Larsen; Lynch, Henry T; Palaniappan, Selvi; Wise, Paul E; Senter, Leigha

    2012-08-01

    Identifying individuals who have Lynch syndrome (LS) involves a complex diagnostic work up that includes taking a detailed family history and a combination of various genetic and immunohistochemical tests. The National Society of Genetic Counselors (NSGC) and the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA-ICC) have come together to publish this clinical practice testing guideline for the evaluation of LS. The purpose of this practice guideline is to provide guidance and a testing algorithm for LS as well as recommendations on when to offer testing. This guideline does not replace a consultation with a genetics professional. This guideline includes explanations in support of this and a summary of background data. While this guideline is not intended to serve as a review of LS, it includes a discussion of background information on LS, and cites a number of key publications which should be reviewed for a more in-depth understanding of LS. These guidelines are intended for genetic counselors, geneticists, gastroenterologists, surgeons, medical oncologists, obstetricians and gynecologists, nurses and other healthcare providers who evaluate patients for LS.

  12. The Patient’s Pain in Her Own Words: Margaret Mathewson’s ‘Sketch of Eight Months a Patient, in the Royal Infirmary of Edinburgh, A.D. 1877’

    Directory of Open Access Journals (Sweden)

    Mary Wilson Carpenter

    2012-12-01

    Full Text Available It has been commonly assumed that nineteenth-century hospital patients were objectified, silenced, treated as the 'accident' of their disease, to use Michel Foucault's term, and also that as charity patients they were largely illiterate paupers, and consequently did not write accounts of their hospital experience. One such account has been known, however, since the 1970s, when W. B. Howie and S. A. B. Black published two articles in medical journals on Margaret Mathewson's 'Sketch of Eight Months a Patient, in the Royal Infirmary of Edinburgh, A.D. 1877'. Martin Goldman subsequently published excerpts from the 'Sketch' in 'Lister Ward' (1987. But Mathewson's account of her experience as a surgical patient of Joseph Lister has never been published in its entirety, nor has it been known that the two existing copies of the manuscript differ extensively, as Mathewson decided to leave out 'some insignificant items and put in others more interesting' in the later version. Admitted because Lister thought he could save her arm from amputation by excision of her tuberculous shoulder joint, her narrative vividly details what it was like to be a surgical patient in Scotland in 1877. Her revisions to that narrative provide clues as to what she thought prudent to exclude from her account, after friends had asked her to publish it. As a charity patient, she was subordinated to the hospital staff, expected to wait uncomplainingly and to accept whatever treatment was given. But her 'Sketch' reveals such unexpected and surprising information as the willingness of the staff, including Lister himself, to teach her and other patients about the nature of their disease and also how to care for themselves, especially how to change their own dressings. Even more startling, Mathewson's narrative documents her confrontation of a 'cruel dresser', a medical student whom she believed to be deliberately causing her pain when he changed her dressing and manipulated her arm

  13. Thompson's Margaret Thatcher illusion: when inversion fails.

    Science.gov (United States)

    Rakover, S S

    1999-01-01

    It is argued that the whole face is more dominant than the individual features. In the case of a jumbled face the external pattern is dominant when a face is upright, whereas the internal pattern is dominant when a face is inverted.

  14. Taanlaste projektikunst, eestlaste maalikunst / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2003-01-01

    Taani kaasaegse kunsti näitusest "Projekt" Tallinna Kunstihoones. Kaasa teevad ka eesti kunstitudengid. Carsten Schmidt-Olseni, Lise Sattrupi ja Lene Degetti, Mads Lynnerupi, rühmituse N55 projektid, eesti tudengite projekt Snail Shell System. Maarit Murka ja Tõnis Saadoja hüperrealistlike maalide näitus Vaal galeriis

  15. Taanlaste projektikunst, eestlaste maalikunst / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2003-01-01

    Taani kaasaegse kunsti näitusest "Projekt" Tallinna Kunstihoones. Kaasa teevad ka eesti kunstitudengid. Carsten Schmidt-Olseni, Lise Sattrupi ja Lene Degetti, Mads Lynnerupi, rühmituse N55 projektid, eesti tudengite projekt Snail Shell System. Maarit Murka ja Tõnis Saadoja hüperrealistlike maalide näitus Vaal galeriis

  16. 改良B-Lynch缝合联合宫腔填纱在剖宫产术中难治性出血中的应用%Application of modified B-Lynch suture combined with filling uterine cavity with gauze in intractable bleeding during cesarean section

    Institute of Scientific and Technical Information of China (English)

    胡莉琴; 章桂莲; 黄贤梅

    2012-01-01

    Objective o To explore the curative effect of modified B - Lynch suture combined with filling uterine cavity with gauze in intractable bleeding during cesarean section. Methods: Eighteen patients who were found with intractable bleeding during cesarean section from May 2008 to June 2011 were selected, including twelve patients with placenta previa, one patient with shallow placental implantation, two patients with placental abruption and uterine apoplexy, and three patients with uterine inertia. Modified B - Lynch suture combined with filling uterine cavity with gauze was used for hemostasis by compression. Results: Bleeding was stopped in the eighteen patients, gauze was pulled out after 24 hours, and bleeding didnt appeared. After operation, two patients were found with temperature more than 38. 5t, and One patient was found with temperature more than 39%. All the patients left the hospital at 5 -7 days after operation, involution of uterus was good at 42 days after delivery. Conclusion: The clinical efficacy of modified B - Lynch suture combined with filling uterine cavity with gauze is satisfactory in controlling intractable bleeding during cesarean section, the method is easy to operate and safe, which reserves the reproductive function of the patients and it is worthy to be popularized in clinic.%目的:探讨改良B-Lynch缝合联合宫腔填纱在剖宫产术中难治性出血的治疗效果.方法:选择2008年5月~2011年6月剖宫产术中出现难治性出血18例患者,其中前置胎盘12例,胎盘浅植入1例,胎盘早剥子宫卒中2例,宫缩乏力3例.采用改良B-Lynch缝合联合宫腔填纱压迫止血.结果:18例患者均止血成功,24h取纱未出现再出血.术后体温超过38.5C2例,超过39℃1例.全部病例术后5~7天出院,产后42天子宫复旧良好.结论:改良B-Lynch缝合联合宫腔填纱控制剖宫产术中难治性出血效果满意,操作简单、安全,保留了患者生育机能,值得临床推广应用.

  17. Medical image of the week: Lynch syndrome

    Directory of Open Access Journals (Sweden)

    Athale A

    2016-11-01

    Full Text Available No abstract available. Article truncated at 150 words. A 43-year-old woman with a history of anemia, thrombocytopenia, and recent treatment for pyelonephritis was transferred to our hospital for increasing shortness of breath. Four months prior to admission, she developed unprovoked bilateral deep vein thrombosis (DVT and pulmonary emboli (PE and was started on rivaroxaban at that time. At presentation, she was complaining of worsening shortness of breath, heavy menstrual bleeding and pain in her calves. CT angiography of chest showed multiple pulmonary emboli to the lower lobes and left upper lobe (Figure 1 and lower extremity venous Doppler showed extensive, acute deep vein thrombosis involving the femoral, popliteal and calf veins bilaterally. Rivaroxaban was held due to anemia and thrombocytopenia and there was concern for respiratory failure since she developed new DVT and PE. She was transfused with 1 unit of packed red blood cells and started on a heparin drip. She continued to have significant menorrhagia, the ...

  18. 100 years lynch syndrome

    DEFF Research Database (Denmark)

    Bleiker, Eveline M A; Esplen, Mary Jane; Meiser, Bettina

    2013-01-01

    by an overview of important psychosocial issues identified in the past 20 years. The identification of mismatch repair genes in 1993-1994 made possible genetic counseling and testing for patients who had cancer and for potentially high-risk relatives without cancer. At that time, concerns were raised about......, reproductive technology utilization, and professional psychosocial support needs of members of families with LS. Finally, challenges for the future are discussed, including population screening and genomic testing....

  19. Twenty hanging Dolls and a Lynching:

    DEFF Research Database (Denmark)

    Risør, Helene

    2010-01-01

    paradoxical entanglement with the enactments of citizenship and state-citizen relations, the article argues that people's attempts to remain safe constitute a permanent process of making visible and defacing (following Michael Taussig's notion of defacement) dangerousness and criminal subjects vis...

  20. Massachusetts Supplemental - Lynch vs. Rank File

    Data.gov (United States)

    Social Security Administration — Result of a Court Case. To identify, to the States (except Massachusetts and others who have opted out), Title 2 beneficiaries who had lost SSI benefits during the...

  1. Emotional Autonomy Redux: Revisiting Ryan and Lynch.

    Science.gov (United States)

    Lamborn, Susie D.; Steinberg, Laurence

    1993-01-01

    Compared adjustment scores among adolescents who differ in both emotional autonomy and perceptions of parental support. Found that, although adolescents who scored high in both emotional autonomy and relationship support reported more internal distress and behavior problems than less autonomous adolescents, they had higher levels of psychological…

  2. Appraisal of Visual Semiosis in Journalistic Discourse-A Case Study of News Reports on Death of Margaret Thatcher%新闻图像符号的评价意义研究--以英国报刊对撒切尔夫人逝世的报道为例

    Institute of Scientific and Technical Information of China (English)

    王伟

    2015-01-01

    为了更好地理解图像新闻所渗透的个人与媒体的态度,结合系统功能语言学框架下的视觉语法和评价系统以及图文关系理论,分析图像符号的评价资源。以英国主流媒体对撒切尔夫人逝世的报道为例,阐释图像的互动意义评价和图文关系引发的评价意义,以阐明新闻中的图片本身以及图像与文本的关系都蕴含着的意识形态。%In order to uncover the attitude produced in news photos,the paper,from the perspective of Visual Grammar and Appraisal Theory,along with text-image relations,analyzes the attitudinal resources implied in visual signs. It then conducts a case study of reports on death of Margaret Thatcher by mainstream British newspapers to look into the detailed functioning of attitudes included in the photos amidst these selected media in terms of both the photo in itself and the image-text relation.

  3. Observation of curative effect of modified B-Lynch suture combined with intrauterine balloon tamponade in the treatment of postpartum hemorrhage caused by uterine inertia%改良B-lynch缝合联合水囊填塞法治疗宫缩乏力性产后出血的疗效观察

    Institute of Scientific and Technical Information of China (English)

    刘丽霞

    2016-01-01

    Objective To evaluate the efficacy of modified B-Lynch suture combined with intrauterine balloon tamponade in the treatment of postpartum hemorrhage caused by uterine inertia.Methods 38 cases of postpartum hemorrhage caused by uterine inertia in our department from January 2011 to December 2015 underwent modified B-Lynch suture combined with intrauterine balloon tamponade (observation group),23 cases of postpartum hemorrhage caused by uterine inertia in our department from January 2006 to December 2010 underwent intrauterine balloon tamponade (control group).Clinical efficacy,hemostatic time,the amount of bleeding,and complications were compared between two groups.Results The effective rate of observation group was 94.7% (36/38),significantly higher than that of control group [73.9% (17/23)],with statistically significant difference between two groups (P<0.05).The operation time of observation group was longer than that of control group,the hemostasis time of observation group was shorter than that of control group,with statistically significant differences between two groups (P<0.05).There were no complications such as water sac shedding or cervical necrosis in both groups.Conclusion Modified B-Lynch suture combined with intrauterine balloon tamponade is effective in the treatment of postpartum hemorrhage caused by uterine inertia.%目的 探讨改良B-lynch缝合联合水囊填塞法治疗宫缩乏力性产后出血的临床治疗效果.方法 2011年1月至2015年12月采用改良B-lynch缝合联合水囊填塞法治疗的38例宫缩乏力性产后出血患者作为观察组,2006年1月至2010年12月单纯采用水囊填塞法治疗的23例宫缩乏力性产后出血患者为对照组.比较两组患者的临床疗效、止血时间、出血量及相关并发症.结果 观察组有效率为94.7%(36/38),显著高于对照组的73.9%(17/23),两组临床疗效比较差异有统计学意义(P<0.05).观察组手术时间长于对照组、止血时间

  4. The Yarn Filling in Uterine Cavity and Improved B-Lynch Suture in the Treatment of Intractable Hemorrhage in Cesarean Section%宫腔填纱条与改良B-Lynch缝合治疗剖宫产术中难治性出血的体会

    Institute of Scientific and Technical Information of China (English)

    梁日新

    2015-01-01

    目的:探讨宫腔填纱条与改良B-Lynch缝合治疗剖宫产术中难治性出血的临床应用及疗效,并观察和分析其安全性。方法:选择笔者所在医院2007年1月-2013年12月剖宫产难治性出血患者共40例,分为对照组和研究组,每组20例。对照组应用宫腔填纱条,研究组应用改良B-Lynch缝合法,观察治疗效果、术中出血量、术后阴道出血量及并发症,并观察6个月后月经来潮等指标。结果:两组均能有效控制产后出血,有效率达100%。研究组术中出血量、手术时间和阴道出血量、术后感染率、输血和住院时间分别为(894.63±67.21)ml、(76.13±8.52)min、(25.17±4.63)ml、0、(661.57±30.32)ml和(7.12±0.96)d,均低于对照组,两组比较差异均有统计学意义(P0.05)。结论:改良B-Lynch缝合治疗剖宫产术中难治性出血的止血效果明显优于宫腔填纱条法,止血迅速可靠,能够降低患者并发症。%Objective:To explore the clinical application and effect of the yarn filling in uterine cavity and improved B-Lynch suture for the treatment of intractable hemorrhage in cesarean section,and observe and analyze its security.Method:40 cesarean section patients with intractable hemorrhage were selected in the hospital from January 2007 to December 2013,they were randomly divided into the control group and the research group,20 cases each group. The control group used the uterine cavity filling yarn,the research group used improved B-Lynch suture.To observe treatment effect,intraoperative blood loss, postoperative vaginal blood loss and complication,and observed 6 months after menstrual cramps and other indicators.Result:Both groups can effectively control postpartum,100%efficient,there was no statistically significant difference(P>0.05).The intraoperative blood loss,operating time and blood loss,postoperative vaginal infection,blood transfusion and length of hospital stay time of the research group

  5. Investigation of Optical Fibers for Coherent Anti-Stokes Raman Scattering (CARS) Spectroscopy in Reacting Flows (Postprint)

    Science.gov (United States)

    2012-03-01

    notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not...OF ABSTRACT: SAR 18. NUMBER OF PAGES 22 19a. NAME OF RESPONSIBLE PERSON (Monitor) a. REPORT Unclassified b. ABSTRACT Unclassified c...Seeger of the University of Erlangen- Nuremberg , Prof. Margaret M. Murnane of the University of Colorado/JILA, and Dr. Hans Stauffer and Ms. Amy Lynch

  6. Observation on Efficacy of Improved B-lynch Sutura Combined with Carboprost Tromethamine in Treatment of Postpartum Hemorrhage Caused by Uterine Inertia%改良B-Lynch缝合术联合卡前列素氨丁三醇治疗宫缩乏力性产后出血的疗效观察

    Institute of Scientific and Technical Information of China (English)

    肖先绪; 郑红梅

    2016-01-01

    OBJECTIVE:To investigate the efficacy and safety of improved b-lynch sutura combined with carboprost tromethamine in treatment of postpartum hemorrhage caused by uterine inertia .METHODS:102 patients with postpartum hemorrhage caused by uterine inertia admitted from Apr .2011 to Apr.2015 were selected to be divided into two groups .Both groups were treated with traditional treatment , and the control group ( 51 cases ) additionally received carboprost tromethamine , the observation group ( 61 cases ) were additionally given improved b-lynch sutura combined with carboprost tromethamine .The efficacy and occurrence of adverse drug reactions were compared between two groups .RESULTS: The mean operative time of observation group was ( 165.3 ±33.2 ) min, significantly shorter than that of control group [ ( 226.5 ±25.4 ) min ] , with statistically significant difference ( P0.05 ) .After treatment , the bleeding rate of postoperative 2 h, hysterectomy rate and hemostatic efficiency of observation group were significantly higher than that of control group , with statistically significant difference ( P<0.05 ) .The incidence of stomachache , ileus and puerperalism of observation group were significantly lower than that of control group , with statistically significant difference (P<0.05).There was no complications of intestinal adhesion in both groups .CONCLUSIONS:The efficacy of improved b-lynch sutura combined with carboprost tromethamine in treatment of postpartum hemorrhage caused by uterine inertia is remarkable , with high safety , which is worthy of application and promotion .%目的:改良B-Lynch缝合术联合卡前列素氨丁三醇治疗宫缩乏力性产后出血的控血效果及安全性。方法:纳入2011年5月—2015年5月收治的102例剖宫产术中发生宫缩乏力的患者,以随机数字表法分为2组。2组患者均给予传统治疗方案,对照组患者(51例)加用卡前列素氨丁三醇,观察组患者(61例)则加用

  7. Between Scylla and Charybdis: Margaret Archer's social realism

    National Research Council Canada - National Science Library

    Nuno Oliveira

    2011-01-01

    ... that may delineate the strengths and weaknesses of social realism as conceived by Archer. For this reason,we put forward three vectors of analysis, through which to set the two approaches against each other...

  8. Näitus kui publiku-uuring / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2008-01-01

    Eve Kiileri näitus "Muuseumilabor" Tallinna Kunstihoone galeriis 26. IX-19. X. Tutvuda saab Kiasmas, Kumus, Briti Muuseumis, Palais de Tokyos, Hamburger Bahnhofis, Vatikani muuseumis, Veneetsia biennaalil läbi viidud publiku-uuringute tulemustega. Publikuteemaline seminar-ümarlaud 16. X

  9. Environmental Dystopias: Margaret Atwood and the Monstrous Child

    Science.gov (United States)

    Bone, Jane

    2016-01-01

    The future of childhood is often described in terms of utopian thinking. Here, the turn is towards dystopia as a fertile source of wild imaginings about the future. The dystopian literary fictions featured here act as a message and are projections of an uneasy future requiring a reader to see the present differently. Such projections make reading…

  10. The education system of Zambia after independence / Margaret Sandlane

    OpenAIRE

    Sandlane, Margaret

    1989-01-01

    Chapter 1 looks into the following matters: • Problem or Research: The problem of research is: * to determine the changes that look place with regard to the structure or the Zambian Education System with respect to the Educational Reform and needs of the people after Independence. * to determine the changes in educational policy, organizational structure, school system and supportive services as a result of the Educational Reform in the post independence era. • Aims...

  11. Riverside Nursing Home, Toberburr Road, St. Margarets, Co. Dublin.

    LENUS (Irish Health Repository)

    Shankar, Ganesh M

    2009-11-23

    Abstract Synapse loss is an early and invariant feature of Alzheimer\\'s disease (AD) and there is a strong correlation between the extent of synapse loss and the severity of dementia. Accordingly, it has been proposed that synapse loss underlies the memory impairment evident in the early phase of AD and that since plasticity is important for neuronal viability, persistent disruption of plasticity may account for the frank cell loss typical of later phases of the disease. Extensive multi-disciplinary research has implicated the amyloid β-protein (Aβ) in the aetiology of AD and here we review the evidence that non-fibrillar soluble forms of Aβ are mediators of synaptic compromise. We also discuss the possible mechanisms of Aβ synaptotoxicity and potential targets for therapeutic intervention.

  12. The Image of the Right Honourable Margaret Thatcher.

    Science.gov (United States)

    Auer, J. Jeffery

    1979-01-01

    Reviews the career of Prime Minister Thatcher and her participation in the campaign for her election. Identifies the five most salient elements in her image and within the general context of contemporary political communication in Britain: cultural identification, accent and word choice patterns, Tory message, sex, and sense of conviction. (JMF)

  13. Näitus kui publiku-uuring / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2008-01-01

    Eve Kiileri näitus "Muuseumilabor" Tallinna Kunstihoone galeriis 26. IX-19. X. Tutvuda saab Kiasmas, Kumus, Briti Muuseumis, Palais de Tokyos, Hamburger Bahnhofis, Vatikani muuseumis, Veneetsia biennaalil läbi viidud publiku-uuringute tulemustega. Publikuteemaline seminar-ümarlaud 16. X

  14. Lätlaste ambitsioonikad plaanid ja kitsad eelarveread / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2009-01-01

    Läti kultuuriministri kohalt 13. jaanuaril 2009 tagasi astunud Helena Demakova juhitud kultuuriministeeriumi 2005. a. vastuvõetud "Kolme venna projektist", mis nägi ette rahvusraamatukogu (ehitus algas 2008. a.), kaasaegse kunsti muuseumi (arhitekt Rem Koolhaas) ja kontserdimaja üheaegse ehitamise Riia kesklinna. 2009. a. veebruaris anti välja uus kaasaegse kunsti ehk Vilhelms Purvītise auhind, mille pälvis Katrīna Neiburga

  15. Moskva muuseumi direktor ja kuraator silmitsi tsensuuriga / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2009-01-01

    Kohtuasjast Andrei Sahharovi muuseumis Moskvas eksponeeritud näitust "Keelatud kunst 2006" kureerinud muuseumi töötajate üle. Kuraator Andrei Jerofejev oli koondanud näitusele Moskva galeriides ja muuseumides ühe aasta jooksul keelatud kunstiteosed

  16. Liituv Türgi on Euroopa strateegiline valik / Margaret Beckett

    Index Scriptorium Estoniae

    Beckett, Margaret

    2006-01-01

    Suurbritannia välisminister on arvamusel, et ainus võimalus saavutada muutusi Türgis ja turvalisust Küprosel on tagada Türgi liitumisprotsessi teelpüsimist, hoides Türgi dialoogi Euroopaga ning valitsuse huvi Küprosega seotud probleemidele lahenduste otsimiste vastu

  17. Veneetsia biennaali tunnustatud ja kunstihinnad Baselis / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2009-01-01

    53. Veneetsia biennaalil pälvis peaauhinna Kuldlõvi Bruce Nauman, elutööpreemiad said Yoko Ono ja John Baldessari (USA), noore kunstniku preemia Hõbelõvi Nathalie Djurberg (Rootsi). Biennaali parimaks kuraatoritiimiks tunnistati Skandinaavia ühispaviljoni kujundanud duo Michael Elmgreen (Taani) ja Ingar Dragset (Norra). Baseli kunstituru oksjonitel ei ole kunstihinnad majandusolukorrale vaatamata eriti langenud

  18. Environmental Dystopias: Margaret Atwood and the Monstrous Child

    Science.gov (United States)

    Bone, Jane

    2016-01-01

    The future of childhood is often described in terms of utopian thinking. Here, the turn is towards dystopia as a fertile source of wild imaginings about the future. The dystopian literary fictions featured here act as a message and are projections of an uneasy future requiring a reader to see the present differently. Such projections make reading…

  19. Lätlaste ambitsioonikad plaanid ja kitsad eelarveread / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2009-01-01

    Läti kultuuriministri kohalt 13. jaanuaril 2009 tagasi astunud Helena Demakova juhitud kultuuriministeeriumi 2005. a. vastuvõetud "Kolme venna projektist", mis nägi ette rahvusraamatukogu (ehitus algas 2008. a.), kaasaegse kunsti muuseumi (arhitekt Rem Koolhaas) ja kontserdimaja üheaegse ehitamise Riia kesklinna. 2009. a. veebruaris anti välja uus kaasaegse kunsti ehk Vilhelms Purvītise auhind, mille pälvis Katrīna Neiburga

  20. A reply to the replies – Counterplea by Jake Lynch

    Directory of Open Access Journals (Sweden)

    Jake Lynch

    2007-10-01

    Full Text Available In this paper the author responds to the counterpleas by David Loyn (“Good journalism or peace journalism?” and Thomas Hanitzsch (“It should be fair to criticize even noble ideas” published in the same issue of conflict & communication online (http://www.cco.regener-online.de/2007_2/inhalt6_2.htm.

  1. Revised guidelines for the clinical management of Lynch syndrome (HNPCC)

    DEFF Research Database (Denmark)

    Vasen, Hans F A; Blanco, Ignacio; Aktan-Collan, Katja

    2013-01-01

    important clinical questions. Then a systematic literature search was performed using the Pubmed database and manual searches of relevant articles. During the workshops the outcome of the literature search was discussed in detail. The guidelines described in this paper may be helpful for the appropriate...

  2. Pathological assessment of mismatch repair gene variants in Lynch syndrome

    DEFF Research Database (Denmark)

    Rasmussen, Lene Juel; Heinen, Christopher D; Royer-Pokora, Brigitte;

    2012-01-01

    . Also, identifying family members that do not carry the variant is important so they can be released from the intensive surveillance. Determining which genetic variants are pathogenic and which are neutral is a major challenge in clinical genetics. The profound mechanistic knowledge on the genetics...

  3. Indsigter og udfordringer i danske Lynch-syndrom-familier

    DEFF Research Database (Denmark)

    Therkildsen, Christina; Timshel, Susanne; Nilbert, Mef

    2008-01-01

    The Danish Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Register is a national resource that registers families with hereditary colorectal cancer. HNPCC is the most common type of hereditary colorectal cancer and carries an increased risk of other tumor types. Genetic diagnostics has identif...

  4. Industriaalpärand, skvottijad ja kaasaegne kultuur = Industrial Legacy. Squatters and Modern Culture / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2007-01-01

    Kultuuritehastest kui ühest kaasaegsest linna arendamise viisist. Kriitiliselt käsitletakse initsiatiivide väljavaateid Eestis ja vaadeldakse mõningaid tulemusteta jäänud kultuuritehaste projekte. Lisaks kahele Tallinnas tegutsevale kultuuritehasele - Polymerile ja Kultuurikatlale - kavandatakse sarnaste linnakute rajamist ka Tartrusse ning mujale Eesti linnadesse

  5. Killarney Community Hospitals (Fuschia, Hawthorn and Heather Wards), St Margaret's Road, Killarney, Kerry.

    LENUS (Irish Health Repository)

    McNabola, Aonghus

    2009-02-01

    According to World Health Organisation figures, 30% of all cancer deaths, 20% of all coronary heart diseases and strokes and 80% of all chronic obstructive pulmonary disease are caused by cigarette smoking. Environmental Tobacco Smoke (ETS) exposure has also been shown to be associated with disease and premature death in non-smokers. In response to this environmental health issue, several countries have brought about a smoking ban policy in public places and in the workplace. Countries such as the U.S., France, Italy, Ireland, Malta, the Netherlands, Sweden, Scotland, Spain, and England have all introduced policies aimed at reducing the population exposure to ETS. Several investigations have monitored the effectiveness of these smoking ban policies in terms of ETS concentrations, human health and smoking prevalence, while others have also investigated a number of alternatives to smoking ban policy measures. This paper reviews the state of the art in research, carried out in the field of ETS, smoking bans and Tobacco Control to date and highlights the need for future research in the area.

  6. Kuidas sünnivad näitused? / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2008-01-01

    Eesti Kaasaegse Kunsti Muuseumist (EKKM) Tallinnas Põhja puiesteel. Näitusest "Kõik tahaks kõnelda", kuraator Rael Artel. Eksponeeritakse Epp Kubu, Andrus Lauringsoni, Anna Stina Treumundi, Margit Lõhmuse, Eva Labotkini jt. töid. Üliõpilaste ühistööna valminud plakatist "Mõistus, tule koju", juhendaja Eha Komissarov

  7. Festivalipäevik III / Margaret Tali, Anu Allas, Margit Tõnson...[jt.

    Index Scriptorium Estoniae

    2005-01-01

    Rahvusvaheline NU Performance festival "Continental Breakfast" Tallinnas Kanuti Gildi saalis 2.-24. nov. 2005. Hollandlase Kim H. Veltmani loengu formaadis performance "World tree". Katrin Essensoni performance "Designed to make difference". Gob Squad (Saksamaa/Inglismaa) "Super Night Shot".

  8. Festivalipäevik Kanutist II / Anu Allas, Margit Tõnson, Margaret Tali

    Index Scriptorium Estoniae

    Allas, Anu, 1977-

    2005-01-01

    Tallinnas Kanuti Gildi saalis kestab 2.-24. novembrini 2005 a. "Continental Breakfast" Tallinn ehk rahvusvaheline NU Performance festival. 9. novembril esineb BabaLAN (Vlado Gotvan Repnik, Sloveenia ) multimeedia-performance'iga. Eva Meyer Kelleri performance "Surm on kindel" (esitaja Irina Müller)

  9. Freud, females, childbirth, and dissidence: Margarete Hilferding, Karen Horney, and Otto Rank.

    Science.gov (United States)

    Balsam, Rosemary

    2013-10-01

    These three early psychoanalysts, who differed in important ways from Freud, each tried to shift his fundamental beliefs about women's bodies in basic developmental theory. This paper illustrates this point by elaborating their materials concerning the centrality of childbirth. One thematic aspect of Freud's disruptive fights with colleagues lay in his loyalty to phallocratic certainties. These problems still affect us, a century later, even in today's clinically pluralistic climate.

  10. Industriaalpärand, skvottijad ja kaasaegne kultuur = Industrial Legacy. Squatters and Modern Culture / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2007-01-01

    Kultuuritehastest kui ühest kaasaegsest linna arendamise viisist. Kriitiliselt käsitletakse initsiatiivide väljavaateid Eestis ja vaadeldakse mõningaid tulemusteta jäänud kultuuritehaste projekte. Lisaks kahele Tallinnas tegutsevale kultuuritehasele - Polymerile ja Kultuurikatlale - kavandatakse sarnaste linnakute rajamist ka Tartrusse ning mujale Eesti linnadesse

  11. Ajalookirjutuse elav protsess : perestroika / Elina Viljanen ; tõlk. Margaret Tali

    Index Scriptorium Estoniae

    Viljanen, Elina

    2008-01-01

    Näitusest "Toores, küpsetatud ja pakendatud - perestroika kunsti arhiiv" Kiasmas. Kuraatorid Marita Muukkonen ja Ivor Strodolski. Kunstiteosed ja dokumendid toodi endisest NSV Liidust, ka Eestist. Näituse kunstnikest külastasid seda Raoul Kurvitz, Raul Meel ja Leonhard Lapin Eestist

  12. Structures and expectations: A systematic analysis of Margaret Paston’s formulaic and expressive language

    DEFF Research Database (Denmark)

    Wood, Johanna

    2009-01-01

    It is shown how a model based on a critical discourse analysis approach, in conjunction with frame analysis, offers a systematic way to analyse 15th century letters. It is argued that in this framework all contexts are “local contexts”. Letters present particular difficulties because...

  13. Mõtlejate mõjud ja sotsiaalne aktsionism Tallinna galeriides / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2002-01-01

    Marko Laimre näitus "Must pall" Tallinna Kunstihoones, Liina Siibi näitus "Klips" (plakatid, videod) Hansapanga galeriis, Stuudio 22 näitus "déja vu" (graafika) Pärnu mnt. 27 galeriis, Eesti Kunstiakadeemia üliõpilaste joonistused "Tühjus ja Ruum" G-galeriis

  14. Festivalipäevik Kanutist I / Margaret Tali, Riin Kübarsepp, Karin Laansoo...[jt.

    Index Scriptorium Estoniae

    2005-01-01

    NU Performance festivali "Continental Breakfast" Tallinn raames esinesid Kanuti Gildi saalis rootsi kunstnik Saralunden etendusega "Sweet Beat Tour", norra Baktruppen etendusega "DO & UNDO" ja soome kunstnik Tellervo Kalleinen etendusega "Let me"

  15. Festivalipäevik III / Margaret Tali, Anu Allas, Margit Tõnson...[jt.

    Index Scriptorium Estoniae

    2005-01-01

    Rahvusvaheline NU Performance festival "Continental Breakfast" Tallinnas Kanuti Gildi saalis 2.-24. nov. 2005. Hollandlase Kim H. Veltmani loengu formaadis performance "World tree". Katrin Essensoni performance "Designed to make difference". Gob Squad (Saksamaa/Inglismaa) "Super Night Shot".

  16. Festivalipäevik Kanutist II / Anu Allas, Margit Tõnson, Margaret Tali

    Index Scriptorium Estoniae

    Allas, Anu, 1977-

    2005-01-01

    Tallinnas Kanuti Gildi saalis kestab 2.-24. novembrini 2005 a. "Continental Breakfast" Tallinn ehk rahvusvaheline NU Performance festival. 9. novembril esineb BabaLAN (Vlado Gotvan Repnik, Sloveenia ) multimeedia-performance'iga. Eva Meyer Kelleri performance "Surm on kindel" (esitaja Irina Müller)

  17. Tänavu sai Toronto Eesti Kunstnike Koondise Margaret Kevendi nimelise stipendiumi... / Egle Tamm

    Index Scriptorium Estoniae

    Tamm, Egle, 1969-

    2004-01-01

    Stipendiumi said Tartu Kõrgema Kunstikooli tekstiilikunsti üliõpilased Marika Kööbi ja Maarja Metspalu, EKA maalikunsti üliõpilane Katrin Koskaru ning tekstiilikunsti üliõpilane Aili Aamisepp

  18. Ajalookirjutuse elav protsess : perestroika / Elina Viljanen ; tõlk. Margaret Tali

    Index Scriptorium Estoniae

    Viljanen, Elina

    2008-01-01

    Näitusest "Toores, küpsetatud ja pakendatud - perestroika kunsti arhiiv" Kiasmas. Kuraatorid Marita Muukkonen ja Ivor Strodolski. Kunstiteosed ja dokumendid toodi endisest NSV Liidust, ka Eestist. Näituse kunstnikest külastasid seda Raoul Kurvitz, Raul Meel ja Leonhard Lapin Eestist

  19. Kuidas sünnivad näitused? / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2008-01-01

    Eesti Kaasaegse Kunsti Muuseumist (EKKM) Tallinnas Põhja puiesteel. Näitusest "Kõik tahaks kõnelda", kuraator Rael Artel. Eksponeeritakse Epp Kubu, Andrus Lauringsoni, Anna Stina Treumundi, Margit Lõhmuse, Eva Labotkini jt. töid. Üliõpilaste ühistööna valminud plakatist "Mõistus, tule koju", juhendaja Eha Komissarov

  20. A designated centre for people with disabilities operated by St Margaret's Centre, Dublin 4

    LENUS (Irish Health Repository)

    Kubiak, Christine

    2009-10-16

    Abstract Background Thorough knowledge of the regulatory requirements is a challenging prerequisite for conducting multinational clinical studies in Europe given their complexity and heterogeneity in regulation and perception across the EU member states. Methods In order to summarise the current situation in relation to the wide spectrum of clinical research, the European Clinical Research Infrastructures Network (ECRIN) developed a multinational survey in ten European countries. However a lack of common classification framework for major categories of clinical research was identified, and therefore reaching an agreement on a common classification was the initial step in the development of the survey. Results The ECRIN transnational working group on regulation, composed of experts in the field of clinical research from ten European countries, defined seven major categories of clinical research that seem relevant from both the regulatory and the scientific points of view, and correspond to congruent definitions in all countries: clinical trials on medicinal products; clinical trials on medical devices; other therapeutic trials (including surgery trials, transplantation trials, transfusion trials, trials with cell therapy, etc.); diagnostic studies; clinical research on nutrition; other interventional clinical research (including trials in complementary and alternative medicine, trials with collection of blood or tissue samples, physiology studies, etc.); and epidemiology studies. Our classification was essential to develop a survey focused on protocol submission to ethics committees and competent authorities, procedures for amendments, requirements for sponsor and insurance, and adverse event reporting following five main phases: drafting, consensus, data collection, validation, and finalising. Conclusion The list of clinical research categories as used for the survey could serve as a contribution to the, much needed, task of harmonisation and simplification of the regulatory requirements for clinical research in Europe.

  1. Festivalipäevik Kanutist I / Margaret Tali, Riin Kübarsepp, Karin Laansoo...[jt.

    Index Scriptorium Estoniae

    2005-01-01

    NU Performance festivali "Continental Breakfast" Tallinn raames esinesid Kanuti Gildi saalis rootsi kunstnik Saralunden etendusega "Sweet Beat Tour", norra Baktruppen etendusega "DO & UNDO" ja soome kunstnik Tellervo Kalleinen etendusega "Let me"

  2. 大卫·林奇访谈录%Interview with David Lynch

    Institute of Scientific and Technical Information of China (English)

    普莱瑞·米勒; 蔡卫

    2003-01-01

    @@ 另类的电影人大卫·林奇通过他的新片故伎重演,在对观众实施催眠的同时又在对观众进行迷惑.这部故事发生在洛杉矶的影片探讨了这座城市精神分裂式的本性,它是纯真与腐败、爱恋与孤独、美好与堕落之间令人不安的融合.也许这些对立映射了林奇本人的生活,就是他既与洛杉矶好莱坞电影业努力保持合作关系、又极力保持自己的艺术个性.

  3. David Lynch's Sayings%大卫·林奇语录

    Institute of Scientific and Technical Information of China (English)

    游飞

    2003-01-01

    @@ 最好不要太多地追究事件的含义、或者琢磨怎样去加以解释,不然你就会因恐惧而不敢让事件发生.心理学摧毁了神秘感和一些魔幻性特质.它能够被贬低为某种神经官能症和其它东西,但它目前的名称和界定却使之丧失了神秘性,以及体验巨大和无限的可能.

  4. The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome

    DEFF Research Database (Denmark)

    Watson, Patrice; Vasen, Hans F A; Mecklin, Jukka-Pekka;

    2008-01-01

    strategies for these less common cancers require accurate, age-specific risk estimation. We pooled data from 4 LS research centers in a retrospective cohort study, to produce absolute incidence estimates for these cancer types, and to evaluate several potential risk modifiers. After elimination of 135...... after the median year of birth (p evaluate...

  5. Improvement of endometrial biopsy over transvaginal ultrasound alone for endometrial surveillance in women with Lynch syndrome.

    NARCIS (Netherlands)

    Gerritzen, L.H.; Hoogerbrugge-van der Linden, N.; Oei, A.L.M.; Nagengast, F.M.; Ham, M.A.P.C. van; Massuger, L.F.A.G.; Hullu, J.A. de

    2009-01-01

    In women with hereditary non polyposis colorectal carcinoma (HNPCC) an annual gynaecological surveillance has been recommended because of an increased lifetime risk of developing endometrial and ovarian carcinoma. The aim of this study was to assess the efficacy of gynaecological surveillance with r

  6. DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch Syndrome

    OpenAIRE

    Poulogiannis, George; Frayling, Ian; Arends, Mark

    2009-01-01

    Abstract DNA mismatch repair (MMR) deficiency is one of the best understood forms of genetic instability in colorectal cancer (CRC), and is characterised by the loss of function of the MMR pathway. Failure to repair replication-associated errors due to a defective MMR system allows persistence of mismatch mutations all over the genome, but especially in regions of repetitive DNA known as microsatellites, giving rise to the phenomenon of microsatellite instability (MSI). A high freq...

  7. 75 FR 78745 - Ronald Lynch, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-12-16

    ... ] following day he received a telephone call from ``Jasmine at Modern Lifestyles,'' who asked ``what type of..., acupuncture and eating ``certain anti-inflammatory foods.'' Id. at 210, 214-15. He also maintained that he... prescribing or dispensing of a dangerous drug ``on the Internet for delivery to any person in this state...

  8. The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome

    DEFF Research Database (Denmark)

    Watson, Patrice; Vasen, Hans F A; Mecklin, Jukka-Pekka

    2008-01-01

    persons missing crucial information, cohort included 6,041 members of 261 families with LS-associated MLH1 or MSH2 mutations. All were either mutation carriers by test, probable mutation carriers (endometrial/colorectal cancer-affected), or first-degree relatives of these. Among mutation carriers...... and probable carriers, urologic tract cancer (N = 98) had an overall lifetime risk (to age 70) of 8.4% (95% CI: 6.6-10.8); risks were higher in males (p families (p ... after the median year of birth (p families (p

  9. A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndrome

    DEFF Research Database (Denmark)

    Boonstra, Philip S; Gruber, Stephen B; Raymond, Victoria M

    2010-01-01

    , and this right truncation effect is more pronounced in children than in parents. In this study, we first review different statistical methods for testing genetic anticipation in affected parent-child pairs that address the issue of bias due to right truncation. Using affected parent-child pair data, we compare......Anticipation, manifested through decreasing age of onset or increased severity in successive generations, has been noted in several genetic diseases. Statistical methods for genetic anticipation range from a simple use of the paired t-test for age of onset restricted to affected parent-child pairs...... to a recently proposed random effects model which includes extended pedigree data and unaffected family members [Larsen et al., 2009]. A naive use of the paired t-test is biased for the simple reason that age of onset has to be less than the age at ascertainment (interview) for both affected parent and child...

  10. Frequent mismatch-repair defects link prostate cancer to Lynch syndrome

    DEFF Research Database (Denmark)

    Dominguez-Valentin, Mev; Joost, Patrick; Therkildsen, Christina;

    2016-01-01

    were high-grade tumors with Gleason scores 8-10. Prostate cancer was associated with mutations in MSH2, MLH1 and MSH6 with loss of the respective mismatch repair protein in 69 % of the tumors, though a MSI-high phenotype was restricted to 13 % of the tumors. The cumulative risk of prostate cancer...

  11. Bayesian Modeling for Genetic Anticipation in Presence of Mutational Heterogeneity: A Case Study in Lynch Syndrome

    DEFF Research Database (Denmark)

    Boonstra, Philip S; Mukherjee, Bhramar; Taylor, Jeremy M G

    2011-01-01

    Summary Genetic anticipation, described by earlier age of onset (AOO) and more aggressive symptoms in successive generations, is a phenomenon noted in certain hereditary diseases. Its extent may vary between families and/or between mutation subtypes known to be associated with the disease phenoty...

  12. A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndrome

    DEFF Research Database (Denmark)

    Boonstra, Philip S; Gruber, Stephen B; Raymond, Victoria M

    2010-01-01

    Anticipation, manifested through decreasing age of onset or increased severity in successive generations, has been noted in several genetic diseases. Statistical methods for genetic anticipation range from a simple use of the paired t-test for age of onset restricted to affected parent-child pairs......, and this right truncation effect is more pronounced in children than in parents. In this study, we first review different statistical methods for testing genetic anticipation in affected parent-child pairs that address the issue of bias due to right truncation. Using affected parent-child pair data, we compare...... to a recently proposed random effects model which includes extended pedigree data and unaffected family members [Larsen et al., 2009]. A naive use of the paired t-test is biased for the simple reason that age of onset has to be less than the age at ascertainment (interview) for both affected parent and child...

  13. Screening for urinary tract cancer with urine cytology in Lynch syndrome and familial colorectal cancer

    DEFF Research Database (Denmark)

    Myrhøj, T; Andersen, M-B; Bernstein, I

    2008-01-01

    AIM: The aim of this study was to evaluate if Urine Cytology (UC) is an appropriate screening procedure for detecting urinary tract neoplasia at an early stage in persons at risk in Hereditary Non-Polyposis Colorectal Cancer families. METHOD: In the National Danish HNPCC-register persons at risk...

  14. The Failure of Lehman Brothers and Merril Lynch: A Lesson for the ...

    African Journals Online (AJOL)

    DR Nneka

    procedures were not instituted rather they depend on subprime mortgage ... Andabai (2011) asserted that, bank failures in emerging financial system had dramatic effects on their economics, and even when crisis are prevented, the cost of.

  15. Educational Lynching: Critical Race Theory and the Suspension of Black Boys

    Science.gov (United States)

    Payne, Macheo

    2010-01-01

    Looking at the disproportionate suspension of African American, Black male students through the lens of critical race theory, this presents arguments from a CRT how the disproportionate suspension of Black male students is rooted in white supremacy and racist policy in the United States. Local recommendations are offered for Oakland Unified School…

  16. Pestilence, riots, lynchings and desecration of corpses. The sleep of reason produces monsters.

    Science.gov (United States)

    Sabbatani, Sergio; Fiorino, Sirio

    2016-06-01

    Vampirism has been a component of Central European and Balkan folklore since the Middle Ages and was often believed to be responsible for the transmission of serious infectious diseases such as plague and tuberculosis/consumption. Vampirism was believed to be spread within the same family or village and if the rite of the so-called second burial after death was not performed. The practice of "second burial" entailed exhumation of the body and the removal of the shroud from the mouth of the corpse, and a search for evidence if the corpse had chewed the cloth. If the shroud was chewed, a handful of earth or a brick was put into the body's mouth so that the vampire could no longer harm others. In some cases, the corpse was decapitated and an awl, made of ash, was thrust into its chest. Furthermore, the limbs were nailed down to prevent its movements. Remarkably, these beliefs were not restricted to the popular classes, but were also debated by theologians, political scientists at the height of the eighteenth century (Enlightenment). In the Habsburg Empire, this question attained such important political, social as well as health connotations as to force the Empress Maria Theresa to entrust an ad hoc study to her personal physician Gerard van Swieten with a view to determining what was true about the apparitions of vampires that occurred throughout central Europe and in the Balkans. The result of this investigation led to a ban on the "second burial" rites. Despite this prohibition, the practice of necrophilia on the bodies of suspected people continued, and both a cultured and popular literature on vampirism continued to flourish well into the nineteenth century.

  17. Diagnosis of Lynch Syndrome: Genetic Testing Identifies a Potentially Deadly Hereditary Disease

    Science.gov (United States)

    ... the sequencing can identify variants in a person’s genes—places where their genetic sequence differs from an expected sequence,” says Katie Lewis, a research coordinator at NIH’s National Human Genome ...

  18. Functional characterization of MLH1 missense variants identified in Lynch Syndrome patients

    DEFF Research Database (Denmark)

    Andersen, Sofie Dabros; Liberti, Sascha Emilie; Lützen, Anne;

    2012-01-01

    localization and protein-protein interaction with the dimer partner PMS2 and the MMR-associated exonuclease 1. We show that a significant proportion of examined variant proteins have functional defects in either subcellular localization or protein-protein interactions, which is suspected to lead to the cancer...

  19. Hereditary colorectal cancer syndromes: Epidemiological studies on Peutz-Jeghers syndrome & Lynch syndrome

    NARCIS (Netherlands)

    M.G.F. van Lier (Margot)

    2011-01-01

    textabstractColorectal cancer (CRC) is the second most common malignancy among women after breast cancer, and the third most common malignancy among men after lung and prostate cancer in the European Union. In the Netherlands, approximately 10000 cases are diagnosed each year. CRC is moreover associ

  20. Linguistic features of literary theme: some halliday-type principles applied to surfacing (Margaret Atwood 1972 Linguistic features of literary theme: some halliday-type principles applied to surfacing (Margaret Atwood 1972

    Directory of Open Access Journals (Sweden)

    M. Nélia Scott

    2008-04-01

    Full Text Available Halliday divides the functions of language into three macro-functions' which he calls: ideational function, expressing content, or the propositional content of the speaker's xperiences of the real and inner world; interpersonal function, which is the means whereby we achieve communication, taking on speech roles vis-à-vis other people, complaining, narrating, enquiring, encouraging, etc.; and textual function, which serves to connect discourse, weaving it together. Under this latter function comes the notion of cohesion. Phoric' elements are parts of the reference system needed for a text to be cohesive. We elucidate and refer to 'phoric' elements in more detail below. It is important to note that all these three macro-functions are present at the same time in a text. Halliday divides the functions of language into three macro-functions' which he calls: ideational function, expressing content, or the propositional content of the speaker's xperiences of the real and inner world; interpersonal function, which is the means whereby we achieve communication, taking on speech roles vis-à-vis other people, complaining, narrating, enquiring, encouraging, etc.; and textual function, which serves to connect discourse, weaving it together. Under this latter function comes the notion of cohesion. Phoric' elements are parts of the reference system needed for a text to be cohesive. We elucidate and refer to 'phoric' elements in more detail below. It is important to note that all these three macro-functions are present at the same time in a text.

  1. A Comparison of Some Portions of the Developmental Theories of Daniel N. Stern and Margaret S. Mahler.

    Science.gov (United States)

    Peters, Donn W.

    This paper discusses Daniel N. Stern's (1985) work, "The Interpersonal World of the Infant: A View from Psychoanalysis and Developmental Psychology," with respect to its implications for theory on infant psychosocial development. The paper focuses on two areas: the reconceptualization of psychoanalytic developmental psychology, and the impact on…

  2. Margaret Kennard (1899–1975): Not a ‘Principle’ of Brain Plasticity But a Founding Mother of Developmental Neuropsychology

    Science.gov (United States)

    Dennis, Maureen

    2009-01-01

    According to the ‘Kennard Principle’, there is a negative linear relation between age at brain injury and functional outcome. Other things being equal, the younger the lesioned organism, the better the outcome. But the ‘Kennard Principle’ is neither Kennard’s nor a principle. In her work, Kennard sought to explain the factors that predicted functional outcome (age, to be sure, but also staging, laterality, location, and number of brain lesions, and outcome domain) and the neural mechanisms that altered the lesioned brain’s functionality. This paper discusses Kennard’s life and years at Yale (1931–1943); considers the genesis and scope of her work on early-onset brain lesions, which represents an empirical and theoretical foundation for current developmental neuropsychology; offers an historical explanation of why the ‘Kennard Principle’ emerged in the context of early 1970s work on brain plasticity; shows why uncritical belief in the ‘Kennard Principle’ continues to shape current research and practice; and reviews the continuing importance of her work. PMID:20079891

  3. BOOK REVIEW SOCIOLOGY: UNDERSTANDING A DIVERSE SOCIETY (By: Andersen, Margaret L., and Howard, Francis T., Thomson Learning inc, 2008

    Directory of Open Access Journals (Sweden)

    Arif Makmun

    2014-04-01

    Full Text Available This book is really good to read which contains comprehensive source of insight into the mechanisms of social interaction between diverse social groups within a certain unit of society. The book is instrumental in providing an overview of the differences in ethnicity, gender, class, religion, as well as the geographical origins of individuals who can greatly influence one’s system of values, beliefs and stereotypes. The volume is based on extensive research work that has been carried out by the authors and covers a wide range of topics related to such sociological notions as culture, power, social change, stratification, crime, inequality, social interaction and social structure, among others. The first part of the book is focused on a discussion of sociological perspectives. Part two covers the topic of individuals and society and part three is about social inequalities. The fourth part is dedicated to social institutions and mechanisms of their functioning, whereas the fifth and last part covers the notion of social change.

  4. Kas Margaret Thatcher oli ikka naine? / Kadi Viik ; interv. Kalev Kesküla, Harry Liivrand, Margit Tõnson

    Index Scriptorium Estoniae

    Viik, Kadi

    2005-01-01

    Sotsiaalministeeriumi soolise võrdõiguslikkuse osakonna juhataja Kadi Viik korraldab rahvusvahelise konverentsi "New Masculinity Tallinn 2005" (Uus mehelikkus). Lisaks nimekiri: Eesti nais(kultuuri)juhte

  5. Science at Harvard University: Historical Perspectives, edited by Clark A. Elliott and Margaret W. Rossiter. Lehigh University Press, Bethlehem, 1992

    Directory of Open Access Journals (Sweden)

    Andrew L. Christenson

    1992-05-01

    Full Text Available This volume contains historical studies of several sciences as practiced at Harvard University. Two of these studies have relevance to the history of archaeology. A chapter by Toby Appel focuses upon the scientific career of Jeffries Wyman, first curator of Harvard's Peabody Museum. She contrasts Wyman's unassuming character with the dominating personality of his mentor and contemporary Louis Agassiz. Trained as a medical doctor, Wyman's main love was zoology, particularly comparative anatomy. In his mid-40s, he encountered his first shell midden and was bitten by the archaeology bug. Soon he was doing pioneering excavation in both New England and Florida. In 1866, he was selected to be the curator of the Peabody Museum, primarily upon his strong museum background but also because of the high regard with which he was held by certain influential people. His selection to this position may have made him America's first professional archaeologist. His principal responsibilities were to collect and display archaeological and ethnological specimens and he made great steps in this direction prior to his death in 1874. Wyman's scientific work was poorly known or studied (he is best noted for having made the first scientific description of the gorilla, in part, Appel argues, because he did not seek acclaim or controversy. His greatest influence was locally through personal interactions with students and colleagues. His archaeological work is only briefly discussed in this and the following article, and there is still much to be written about this man of high character.

  6. Nature/nurture and the anthropology of Franz Boas and Margaret Mead as an agenda for revolutionary politics

    Directory of Open Access Journals (Sweden)

    Sidney M. Greenfield

    2001-12-01

    Full Text Available There is much more involved in the nature/nurture debate than an abstract theoretical disagreement among dispassionate scientists. Each side of the debate leads logically to significantly different views of the social order and holds different implications for social policy. In this paper I shall argue that Boas' Anthropology with its emphasis on cultural relativism was as much a social and political agenda as it was a scientific theory. The positions on public policy issues he opposed were informed (and rationalized by what its advocates claimed to be science. To be able to counter the discriminatory policy proposals that followed from this science, it was necessary for Boas both to challenge its validity and then replace it with an alternative that would support a more liberal political agenda. This chapter of anthropology's history gains relevance in today's context as neoevolutionary, reductionist theories once more provide "scientific" support for conservative, separatist and often discriminatory social policies.O debate natureza/cultura é muito mais do que um desentendimento teórico e abstrato entre cientistas desapaixonados. Cada lado do debate leva a visões diferentes da ordem social e traz implicações diferentes para políticas sociais. Neste artigo, sugiro que a Antropologia de Boas, com sua ênfase no relativismo cultural, tanto quanto uma teoria científica, foi um programa social e político. As posturas de política pública às quais ele se opunha eram informadas (e racionalizadas por algo apresentado por seus proponentes como ciência. Para combater as propostas discriminatórias que decorriam desta ciência, cabia a Boas desafiar sua validade e substituí-la por uma alternativa que daria apoio a uma agenda política mais liberal. Esse capítulo da história da antropologia assume maior relevância no contexto atual em que teorias néo-evolucionistas e reducionistas mais uma vez fornecem uma base "científica" para políticas sociais conservadoras, separatistas e freqüentemente discriminatórias.

  7. Kas Margaret Thatcher oli ikka naine? / Kadi Viik ; interv. Kalev Kesküla, Harry Liivrand, Margit Tõnson

    Index Scriptorium Estoniae

    Viik, Kadi

    2005-01-01

    Sotsiaalministeeriumi soolise võrdõiguslikkuse osakonna juhataja Kadi Viik korraldab rahvusvahelise konverentsi "New Masculinity Tallinn 2005" (Uus mehelikkus). Lisaks nimekiri: Eesti nais(kultuuri)juhte

  8. The earliest phases of the parish church of Saint Margaret and Saint Stanislaus in Żębocin

    Directory of Open Access Journals (Sweden)

    Sławomir Dryja

    2012-12-01

    Full Text Available The paper has been based on archaeological and architectural exploration of the church in Żębocin carried out in 2011. Żębocin, a village in the Miechów district and the Proszowice deanery, had its beginnings reportedly in the mid-11th century. However, the first squire of Żębocin documented in historical sources was Tomko, coat of arms unknown, mentioned in 1384. According to tradition, the first church in the village, which has not survived, was built in the years 1059–1071 and consecrated by St. Stanislas of Szczepanów. In a local legend, the wife of knight Mikołaj of Żębocin took shelter in the tower of a stone church in Żębocin during the unrest in the reign of Boleslaus the Brave. The stone foundation under the north-eastern corner of the chancel belonged probably to a stone building, its function unknown, which may have stood there already in those turbulent times. The extant church, erected in the mid-13th century or soon afterwards, was a small single-nave structure with a chancel closed with a straight wall, built from bricks (with a wendian bond pattern on its elevation on stone foundations. It combined two styles: Romanesque (as shown by the surviving splayed window in the northern elevation of the chancel and Gothic (the brick ogival frame in the northern elevation of the nave. The important question whether the church had a tower from the start and where that tower was located remains undecided; the tower could have been incorporated into the body of the nave from the west or built above the chancel; it could also have been added afterwards, in the 16th century at the latest. Reportedly, the church in Żębocin once had a defensive character and was located in knights’ fortified town. Its founder may have been a progenitor of the Strzemieńczyk or the Odrowąż families. It should be remembered that Romanesque single-nave “village” churches built on a simple plan are quite frequent in Central Europe; there are nearly a hundred of them in Poland alone. In Żębocin, the extant tower of the church, the facade and the sacristy at the western side were built no later than ca. 1688.

  9. Flinders Petrie: A Life in Archaeology, 2nd edition, by Margaret S. Drower, University of Wisconsin Press, Madison, 1995

    Directory of Open Access Journals (Sweden)

    Richard B. Woodbury

    1995-11-01

    Full Text Available Sir William Matthew Flinders Petrie, K.B.E., F.R.S., F.B.A., revolutionized Egyptian archaeology in the first two decades (1880- 1900 of his long career: he set new standards by insisting on keeping a complete record of all that was found. including broken as well as whole objects; he introduced the use of pottery styles for dating rather than using only inscriptions; he substituted "a sympathetic and personal relationship" with his workman for the customary use of the lash to spur them on; he rewarded care and vigilance; he extended the list of kings of Egypt back to their beginning; and "his most triumphant and ingenious contribution to archaeological method [was] the system known as Sequence Dating," today called seriation. He also stunned classical archaeolo­gists by dating early the Minoan civilization on the basis of sherds found in dated Egyptian contexts--a technique now familiar as cross-dating. His work was a total contrast to the carelessness and looting that passed for Egyptian archaeology in the 19th and early 20th centuries. His career is painstakingly chronicled here by one of his last students.

  10. Integrating Home and Community into the Curriculum: The Zuni Experience. An Interview with Margaret Eriacho, Kaylene Gchachu, and Odell Jaramillo.

    Science.gov (United States)

    Franklin, Elizabeth, Ed.

    1991-01-01

    In interview excerpts, three teachers at Dowa Yalanne Elementary School on the Zuni Indian Reservation discuss ways they use community resources to help their students learn. The teachers explain the importance of introducing concepts by grounding them in familiar activities from home and community. They suggest that, for them, the…

  11. Marion Dell, Virginia Woolf’s Influential Forebears. Julia Margaret Cameron, Anny Thackeray Ritchie and Julia Prinsep Stephen

    OpenAIRE

    Cassigneul, Adèle

    2016-01-01

    I say Ethel what a happy life you had—in the very cream andmarrow of the 19th Century. I had a glimpse to, but not a long look. Virginia Woolf to Ethel Smith, April 14th 1939 Three strong women In ‘A Sketch of the Past’, Virginia Woolf acknowledges and questions the legacy of her overpowering masculine forebears, laying emphasis on a wide generation gap and on her intermediate position: ‘Father himself was a typical Victorian. George and Gerald were consenting and approving Victorians.’ She o...

  12. Para una des-comprensión filosófica del cine: el caso Inland Empire de David Lynch

    Directory of Open Access Journals (Sweden)

    Julio Cabrera

    2009-05-01

    Full Text Available El trabajo cuestiona la capacidad hermenéutica de la filosofía en su tarea de analizar películas, sosteniendo quetal capacidad dejó de ser apropiada para hacer surgir el sentido y la verdad de obras cinematográficas. Se argumentaque una capacidad interactiva y “performativa” sería más adecuada. Obras cinematográficas como las de David Lynchayudan a entender este paso metodológico y temático desde la noción interpretativa de la verdad hacia la noción interactivade la misma, al construir filmes que se configuran como “imposibles hermenéuticos”. El artículo contiene unaauto-crítica a la propia actitud hermenéutica aún asumida en mi libro Cine: 100 años de filosofía, de 1999.

  13. 论大卫·林奇电影的不确定性%The Uncertainty of David Lynch's Films

    Institute of Scientific and Technical Information of China (English)

    陈慧

    2005-01-01

    从文本的角度研究林奇的电影,我们便可看出其电影的特点是不确定性,这是后现代主义的典型特征之一.探讨林奇电影的不确定性有助于更好地了解其电影作品及艺术.

  14. Chemical, Biological, and Physical Measurements from the Subtropical Western North Atlantic Ocean. Summer 1982, USNS LYNCH, Cruise 710-82.

    Science.gov (United States)

    1985-01-01

    purified luciferin -luciferace system (DuPont Inc., Wilmington, Delaware). The resulting light emission was measured in a sensitive photometer (SAI Inc...35 57.4 N 074 55.4 W Transm 23 1 Transmiss 0 25 June 82 0945 36 56.6 N 075 59.1 W Transm 10 tivity and temperature fine structure seen in the...chlorophyll "a" (chl "a") PHAEOPHYTIN mg/L total phaeopigment (i.e., chlorophyll degradation products) PHOSPHATE ug- atoms /L = AM dissolved

  15. Family perspectives in lynch syndrome becoming a family at risk, patterns of communication and influence on relations

    DEFF Research Database (Denmark)

    Bartuma, Katarina; Nilbert, Mef; Carlsson, Christina

    2012-01-01

    A growing number of individuals are diagnosed with hereditary cancer. Though increased levels of anxiety and depression have been demonstrated around the time of genetic counselling, most individuals handle life at increased risk well. Data have, however, been collected on individual basis, which...... led us to focus on family perspectives of hereditary cancer....

  16. Detección de mutaciones germinales en el gen PMS2 asociado a Síndrome de Lynch

    OpenAIRE

    2014-01-01

    Según la Organización Mundial de la Salud (OMS) el cáncer se define como un término genérico que designa un amplio grupo de enfermedades que pueden afectar a cualquier parte del organismo; también se habla de «tumores malignos» o «neoplasias malignas». Una característica del cáncer es la multiplicación rápida de células anormales que se extienden más allá de sus límites habituales y pueden invadir partes adyacentes del cuerpo o propagarse a otros órganos, proceso conocido como ...

  17. Review: Current writing: Text and reception in Southern Africa

    Directory of Open Access Journals (Sweden)

    A. L. Combrink

    1990-05-01

    Full Text Available Current writing: Text and reception in Southern Africa. (Published by the University of Natal under the joint editorship of Margaret Lenta, Michael Chapman, Margaret Daymond and Johan U. Jacobs. Volume 1, 1989 - editor: Margaret Lenta

  18. 77 FR 26008 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-05-02

    ... License. CLN Worldwide, LLC (NVO & OFF), 1825-C Cross Beam Drive, Charlotte, NC 28217, Officer: David E..., Officers: Robin Lynch, Managing Member (Qualifying Individual), Gina Lynch, Member, Application...

  19. The process of identity construction througt the discourse of art within the Canadian postcolonial context in Cat' eye and The blind assassin by Margaret Atwood

    OpenAIRE

    Massano, María Constanza

    2014-01-01

    Since I started to study this Masters Degree the postmodern problematic has captivated me. Delving deeper into the postmodern literary field I found myself attracted by the fact that much of postmodern literature has been giving voice to minority groups. From that moment my interest was directed towards those texts in which minority groups (former colonies and women primarily) occupy an important role within the realm of fiction. I, therefore, delved into many contemporary writers finding the...

  20. Raison d'Etat, raisons des arts : mõtteid avalike hüvede teemal / Margaret J. Wyszomirski ; tõlk. Johanna Ross

    Index Scriptorium Estoniae

    Wyszomirski, Margaret J.

    2008-01-01

    Kunsti ja avaliku huvi kokkupuutest ning kunsti- ja valitsusasutuste koos toimimisest Ameerika Ühendriikides. Originaali pealkiri : Raisons d'Etat, raisons des arts : thinking about public purposes (The public life of the arts in America. - New Brunswick, New Jersey, London : Rutgers University Press, 2000. Lk. 50-80). Lühidalt autorist lk. 107

  1. 略论撒切尔夫人的外交策略%A Brief Discussion about Margaret Thatcher's foreign policy

    Institute of Scientific and Technical Information of China (English)

    孙科斌

    2012-01-01

    Thatcher government in power for 11 years (1979 -1990), is an important period of British post -war history. After World War II British national decline is more pronounced, which is irreparable. However, as histori- cal conditions show the continuity of foreign policy and a considerable degree of freshness, is a major feature of the Thatcher government. On the diplomatic front, the Thatcher to take a pragmatic, tough, flexible foreign policy. The maximum benefit for the British to revive Britain's great power status is her foreign policy objectives. This also high- lights the fourth Thatcher govemment's foreign policy in several key aspects of the United States, Soviet Union, Eu- rope and the colonies.%撒切尔政府执政的11年(1979—1990),是英国战后历史的一个重要时期。二战后英国国力衰落更加明显,这是无法挽回的。然而,在那样的历史条件下表现出的外交策略的连贯性和相当程度的新鲜感,则是撒切尔政府的一大特色。在外交方面,撒切尔采取务实、强硬、灵活的外交政策。为英国谋取最大利益,重振英国的大国地位是她的外交宗旨。这也突出地体现在撒切尔政府在对美、对苏、对欧和对殖民地的几个主要方面的外交策略上。

  2. 撒切尔政府私有化政策定位分析%An Analysis of the Orientation of Margaret Thatcher Government's Privatization

    Institute of Scientific and Technical Information of China (English)

    毛锐

    2005-01-01

    在撒切尔夫人任期内,英国掀起了声势浩大的私有化运动.这一运动的兴起具有深刻的国际经济政治背景,并受资本主义变化规律的制约.从根本上说,英国的私有化政策是对全球化浪潮的积极反应,是生产力发展的必然结果;私有化也是英国乃至西方发达国家对市场与国家关系的新调整,是资本主义适应社会生产力发展的一次改革,是20世纪80年代以来资本主义国家出现的一个重要的新趋势和新动向.

  3. Three Who Dared: Prudence Crandall, Margaret Douglass, Myrtilla Miner--Champions of Antebellum Black Education. Contributions in Women's Studies, Number 47.

    Science.gov (United States)

    Foner, Philip S.; Pacheco, Josephine F.

    This book recounts the attempts of three women to educate blacks between the 1830's and the Civil War, a period during which, even in the North and the Middle West, there was little concern for the education of blacks because they did not belong to the body politic. All three women endured persecution and hardship, but they provided antislavery…

  4. Raison d'Etat, raisons des arts : mõtteid avalike hüvede teemal / Margaret J. Wyszomirski ; tõlk. Johanna Ross

    Index Scriptorium Estoniae

    Wyszomirski, Margaret J.

    2008-01-01

    Kunsti ja avaliku huvi kokkupuutest ning kunsti- ja valitsusasutuste koos toimimisest Ameerika Ühendriikides. Originaali pealkiri : Raisons d'Etat, raisons des arts : thinking about public purposes (The public life of the arts in America. - New Brunswick, New Jersey, London : Rutgers University Press, 2000. Lk. 50-80). Lühidalt autorist lk. 107

  5. Traumaatilise sündmuse mõju fotograafi loomingule : Margaret Bourke-White'i ja Lee Milleri näitel / Katrin Sarapuu

    Index Scriptorium Estoniae

    Sarapuu, Katrin

    2010-01-01

    Uuritakse kas ja kuidas kajastuvad traumaatilised sündmused ja nende tunnistamine fotograafi loomingus. Selleks analüüsitakse ja võrreldakse mõlema fotograafi sõjaeelseid ja -aegseid töid ning sõjajärgsetele koonduslaagrite külastustele eelnenud ja järgnevat loomingut

  6. Narrative Survival. The Power of Personal Narration, Discussed through the Personal Story-Telling of Fictional Characters, Particularly Those Created by Margaret Atwood.

    Science.gov (United States)

    Shepherd, Valerie

    1995-01-01

    Examines the component parts of personal narrative, the sort of language resources they consist of, and the respective roles they can play in turning sense into experience. People share in the making of their stories, evaluating them creatively with the help of their hearers. To survive in a complex world of meanings, a narrator must constantly…

  7. Literature and the Teaching of Language: A Key to Implicit Rhetoric (or, Why Hok Ming Chan Should Be Reading Margaret Atwood)

    Science.gov (United States)

    Homer, Merlin

    1977-01-01

    There has been an exile of literature from the English as a second language curriculum. Language is a small part of the communication that takes place in a culture. Cultural complexities in literature are valuable for the teaching of second language students. Teaching suggestions and references are provided. (SW)

  8. Research on Margaret Atwood's Subversion and Transcendence on Gothic Novels%论阿特伍德对哥特式小说的颠覆与超越

    Institute of Scientific and Technical Information of China (English)

    陈香玉

    2010-01-01

    哥特式小说作为一个经典的小说类型正逐渐发展和衍变.加拿大"文学女王"阿特伍德承袭了哥特式小说的基本形式,但她不是简单的摹仿和继承,而是颠覆哥特式小说中不合理的因素,如"恶棍式英雄"形象和"古堡"意象.在祛除了哥特式小说中父权文化的偏颇后.阿特伍德成功承袭了哥特式小说的边缘性和颠覆性特征,对社会和人性做了深刻的反思和探讨.

  9. Hyper Spectral Remote Sensing of Tropical and Sub-Tropical Forest (Editors: Margaret Kalacsca & G. Arturo Sances–Publisher: Azofeita CRC Press, Year 2008, 320 pages

    Directory of Open Access Journals (Sweden)

    I Nengah Surati Jaya

    2014-04-01

    Full Text Available It is estimated that most of the problems in forestry associated with the spatial attributes. From the perspective of forest function that includes production, ecological, and social functions, the spatial aspects has always been a very important part. In Indonesia, the forestry areas is always dealing with very large areas which is mostly inaccessible due to limitation of roads, mountainous with steep slopes, cliffs, hills or wetland such as peat, swamp or marsh. This condition makes it difficult to collect the data in quick manner comprehensively with low cost. Veronique et al. (2012 recognized that remote technology may provide objective, practical and cost-effective solution. Currently, one of the most reliable data source that can be repetitively acquired with a unique and consistent traits are those derived from satellite imageries. It had been known that since the 1990s, earth resources remote sensing sensor is progressively developed either with finer spatial resolution, higher spectral resolution, more frequent revisit or wider dynamic range. The advent of high spectral resolution (e.g. hyperspectral is quite challenging and prospectively gives a significant contribution, especially in forest management with higher level of detailed information. Without having adequate spatial information supported by strong scientific arguments, the forestry sector will be persistently pressured by many other sectors.

  10. Traumaatilise sündmuse mõju fotograafi loomingule : Margaret Bourke-White'i ja Lee Milleri näitel / Katrin Sarapuu

    Index Scriptorium Estoniae

    Sarapuu, Katrin

    2010-01-01

    Uuritakse kas ja kuidas kajastuvad traumaatilised sündmused ja nende tunnistamine fotograafi loomingus. Selleks analüüsitakse ja võrreldakse mõlema fotograafi sõjaeelseid ja -aegseid töid ning sõjajärgsetele koonduslaagrite külastustele eelnenud ja järgnevat loomingut

  11. Dunkerque-Falklands: Due eventi storico-politici attraverso l'analisi linguistica dei discorsi di Winston Churchill e Margaret Thatcher (Dunkirk-Falklands: Two Historical-Political Events through the Linguistic Analysis of the Speeches of Winston Churchill and Margaret Thatcher).

    Science.gov (United States)

    Arcaini, Giovanna

    1988-01-01

    The political speech is a unique kind of document that reflects the socio-historic climate of its time. Two historical events (Dunkirk and the Falkland Islands Crisis) and a principal protagonist from each are discussed, and the speeches of these two individuals are analyzed in order to find similarities and differences, and to find their basic…

  12. Dunkerque-Falklands: Due eventi storico-politici attraverso l'analisi linguistica dei discorsi di Winston Churchill e Margaret Thatcher (Dunkirk-Falklands: Two Historical-Political Events through the Linguistic Analysis of the Speeches of Winston Churchill and Margaret Thatcher).

    Science.gov (United States)

    Arcaini, Giovanna

    1988-01-01

    The political speech is a unique kind of document that reflects the socio-historic climate of its time. Two historical events (Dunkirk and the Falkland Islands Crisis) and a principal protagonist from each are discussed, and the speeches of these two individuals are analyzed in order to find similarities and differences, and to find their basic…

  13. David Lynch's Movie World%在梦里他对你说 --大卫·林奇的电影世界

    Institute of Scientific and Technical Information of China (English)

    蔡卫

    2003-01-01

    @@ 空荡的房间低垂着殷红的帷幕,黑白相间的地板上,闪烁着鬼火般的灯光,一个男人僵硬地坐在一张椅子里,空气中弥漫着隐隐人的嗡鸣,渐渐地,嗡鸣声吞没了一只萨克斯管孤独的曲调……一个穿着红西装的侏儒小男人正面对帷幕全身颤抖着难以支撑,他紧紧抓住红色帷幕,仿佛那是他生命依附的力量.渐渐地,一股潜在的生命力涌入侏儒的躯体,他从抽搐中恢复过来,转过身面对着座椅上的男人,然后伴随着强劲的爵士乐曲舞蹈起来.侏儒的嘴唇嚅动着,怪异、模糊的声音在躁动窒息的空间回荡,仿佛在说"来,一起去跳舞……"

  14. A Reflection on David Lynch's Film Style%关于大卫·林奇电影风格的思考

    Institute of Scientific and Technical Information of China (English)

    周艳

    2013-01-01

    通过对林奇电影和好莱坞电影工业的研究表明,大卫·林奇的电影对于好莱坞工业的固有程式实现了勇敢的突破,但时至今日,设若林奇式的电影梦境能够有机植入侦探片、黑帮片抑或现实主义等其他类型片,或者沉潜入更为深广的集体潜意识梦境当中,将会再次因为与当今观众对话的可能而发挥它“惊人的效果”,成为电影中经久不衰的影像表达方式.

  15. Prevalence of MLH1 constitutional epimutations as a cause of Lynch syndrome in unselected versus selected consecutive series of patients with colorectal cancer.

    Science.gov (United States)

    Castillejo, Adela; Hernández-Illán, Eva; Rodriguez-Soler, María; Pérez-Carbonell, Lucía; Egoavil, Cecilia; Barberá, Victor M; Castillejo, María-Isabel; Guarinos, Carla; Martínez-de-Dueñas, Eduardo; Juan, María-Jose; Sánchez-Heras, Ana-Beatriz; García-Casado, Zaida; Ruiz-Ponte, Clara; Brea-Fernández, Alejandro; Juárez, Miriam; Bujanda, Luis; Clofent, Juan; Llor, Xavier; Andreu, Montserrat; Castells, Antoni; Carracedo, Angel; Alenda, Cristina; Payá, Artemio; Jover, Rodrigo; Soto, José-Luis

    2015-07-01

    The prevalence of MLH1 constitutional epimutations in the general population is unknown. We sought to analyse the prevalence of MLH1 constitutional epimutations in unselected and selected series of patients with colorectal cancer (CRC). Patients with diagnoses of CRC (n=2123) were included in the unselected group. For comparison, a group of 847 selected patients with CRC who fulfilled the revised Bethesda guidelines (rBG) were also included. Somatic and constitutional MLH1 methylation was assayed via methylation-specific multiplex ligation-dependent probe amplification of cases lacking MLH1 expression. Germline alterations in mismatch-repair (MMR) genes were assessed via Sanger sequencing and methylation-specific multiplex ligation-dependent probe amplification. Loss of MLH1 expression occurred in 5.5% of the unselected series and 12.5% of the selected series (pprevalence of MLH1 constitutional epimutations in unselected cases of CRC. Therefore, MLH1 constitutional epimutation analysis should be conducted only for patients who fulfil the rBG and who lack MLH1 expression with methylated MLH1. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  16. 浏览器端开发最佳实践:浏览器端的狙击——蔡学镛对话Kevin Lynch

    Institute of Scientific and Technical Information of China (English)

    朱海燕; 常政; 蔡学镛

    2006-01-01

    2005年4月,《程序员》杂志发表专题文章“高效开发团队最佳实践”,时至今日仍然常有读者对当期文章赞不绝口。于是,经过一年多之后,我们又再次回到当时的出发点。

  17. On the Research Methods of the Urban Image of Kevin Lynch%凯文·林奇城市意象研究方法辨析

    Institute of Scientific and Technical Information of China (English)

    杨健; 戴志中

    2007-01-01

    在建筑学研究方法的众多主张中,最引人注目的观点是认为存在着经验主义与理性主义两种根本对立的研究方法.但是,在凯文·林奇的城市意象研究中,我们并没有看到这种决然的二元对立.通过对林奇城市意象研究方法(包括对林奇采用的心理学、现象学研究方法,以及所采用的心理学和人类学文献)所作的考察,试图证明建筑学研究可以是实证与思辨、定量与定性、科学与神话的有机统一.建筑学不排斥诗意,建筑学研究同样不排斥诗意盎然的研究方法.

  18. 凯文·林奇《城市意象》之批判%Critical Reading on Kevin Lynch's The Image of the City

    Institute of Scientific and Technical Information of China (English)

    汪原

    2003-01-01

    凯文@林奇的城市五要素早已广泛运用于城市设计中,以建构更易识别的环境.但其局限性也是显而易见的,即将人对城市环境的理解仅仅看做是对物质形态的知觉认识.通过对凯文@林奇的再解读,不仅指出了城市意象研究的局限性,而且从文化和意识形态方面对意象研究进行了探讨.

  19. 凯文·林奇城市设计教育思想解读%Review of the Urban Design Educational Thought of Kevin Lynch

    Institute of Scientific and Technical Information of China (English)

    董禹; 董慰

    2006-01-01

    凯文·林奇的城市设计思想在世界上影响广泛,本文基于林奇对城市设计的独到见解,从教学内容、教学方法、课程设置、教学机构几个方面介绍并分析了林奇关于城市设计教育的观点,以期能对我国城市设计教育的完善起到借鉴作用.

  20. The introduction of a choice to learn pre-symptomatic DNA test results for BRCA or Lynch syndrome either face-to-face or by letter

    NARCIS (Netherlands)

    Voorwinden, J. S.; Jaspers, J. P. C.; ter Beest, J. G.; Kievit, Y.; Sijmons, R. H.; Oosterwijk, J. C.

    2012-01-01

    In predictive DNA testing for hereditary cancer, test results should traditionally be disclosed face-to-face. Increasingly, however, counselees ask to receive their test result at home by letter. To compare the quality of genetic counselling in the traditional way to a procedure in which counselees

  1. Triple synchronous primary malignancies of the colon, endometrium and kidney in a patient with Lynch syndrome treated via minimally invasive techniques

    Directory of Open Access Journals (Sweden)

    Luis E. Mendez

    2016-08-01

    It is important to consider hereditary cancer syndromes in women with a strong family history presenting with synchronous multiple primary malignancies. A multidisciplinary surgical approach is key to best practices and optimal patient outcomes.

  2. Immunohistochemical staining for p16 and BRAFV600E is useful to distinguish between sporadic and hereditary (Lynch syndrome-related) microsatellite instable colorectal carcinomas.

    Science.gov (United States)

    Boissière-Michot, Florence; Frugier, Hélène; Ho-Pun-Cheung, Alexandre; Lopez-Crapez, Evelyne; Duffour, Jacqueline; Bibeau, Frédéric

    2016-08-01

    DNA mismatch repair (MMR) protein analysis by immunohistochemistry (IHC) can identify colorectal cancer (CRC) with microsatellite instability (MSI). As MLH1-deficient CRC can be hereditary or sporadic, markers to distinguish between them are needed. MLH1 promoter methylation assay is the reference method; however, sometimes, it is challenging on formalin-fixed paraffin-embedded tissue samples. We assessed by IHC the expression of BRAFV600E, p16, MGMT, and CDX2 in 55 MLH1-deficient MSI CRC samples (of which 8 had a germline MLH1 mutation) to determine whether this panel differentiates between sporadic and hereditary CRCs. We also analyzed MLH1 promoter methylation by methylation-specific PCR and pyrosequencing and BRAF status by genotyping. None of the hereditary CRCs showed MLH1 methylation, BRAF mutation, BRAFV600E-positive immunostaining, or loss of p16 expression. We detected MLH1 promoter methylation in 67 % and a BRAF mutation in 42 % of CRC, all showing MLH1 promoter methylation. BRAFV600E IHC and BRAF genotyping gave concordant results in all but two samples. Loss of expression of p16 was found in 30 % of CRC with methylation of the MLH1 promoter, but its expression was retained in all non-methylated and part of MLH1-methylated tumors (100 % specificity, 30 % sensitivity). CDX2 and MGMT expression was not associated with MLH1 status. Thus, BRAFV600E and p16 IHC may help in differentiating sporadic from hereditary MLH1-deficient CRC with MSI. Specifically, p16 IHC might be used as a surrogate marker for MLH1 promoter methylation, because all p16-negative CRCs displayed MLH1 methylation, whereas hereditary CRCs were all p16-positive.

  3. Genetics Home Reference: Peutz-Jeghers syndrome

    Science.gov (United States)

    ... Genetic and Rare Diseases Information Center Frequency The prevalence of this condition is uncertain; estimates range from ... A, Lynch HT, Lynch JF, Howe JR. Hereditary colorectal cancer-part II. Curr Probl Surg. 2005 May;42( ...

  4. 78 FR 69438 - AGOA: Trade and Investment Performance Overview; AGOA: Economic Effects of Providing Duty-Free...

    Science.gov (United States)

    2013-11-19

    ... media should contact Margaret O'Laughlin, Office of External Relations (202-205-1819 or margaret..., including investments by the EU, China, Brazil, and India, and identification of any links between these...

  5. Kant's Theory of virtue

    DEFF Research Database (Denmark)

    Nielsen, Carsten Fogh

    2012-01-01

    Anmeldelse af Anne Margaret Baxleys bog: "Kant's Thery of Virtue. The Value of Autocracy" (Cambridge University Press, 2010)......Anmeldelse af Anne Margaret Baxleys bog: "Kant's Thery of Virtue. The Value of Autocracy" (Cambridge University Press, 2010)...

  6. Thatcherismens selvmodsigelser

    DEFF Research Database (Denmark)

    Böss/Bøss, Michael

    2013-01-01

    Nekrolog over Margaret Thatcher og vurdering af hendes betydning for britisk politik, og for Danmark.......Nekrolog over Margaret Thatcher og vurdering af hendes betydning for britisk politik, og for Danmark....

  7. The United Kingdom: Issues for the United States

    Science.gov (United States)

    2010-06-29

    13 years of Labour government, the Conservatives had led the UK government for a stretch of 18 years, first under Margaret Thatcher (1979-1990...European integration (including, notably, former Prime Minister Margaret Thatcher ). 5

  8. Kant's Theory of virtue

    DEFF Research Database (Denmark)

    Nielsen, Carsten Fogh

    2012-01-01

    Anmeldelse af Anne Margaret Baxleys bog: "Kant's Thery of Virtue. The Value of Autocracy" (Cambridge University Press, 2010)......Anmeldelse af Anne Margaret Baxleys bog: "Kant's Thery of Virtue. The Value of Autocracy" (Cambridge University Press, 2010)...

  9. Feminist Fiction and the Uses of Memory.

    Science.gov (United States)

    Greene, Gayle

    1991-01-01

    This essay concerns feminist fiction by Doris Lessing, Margaret Drabble, Margaret Atwood, Margaret Laurence, and Toni Morrison that utilizes memory as a means to liberation and explores this at the level of narrative form. In examining 1970s feminist fiction and metafiction, explores the importance of memory at particular cultural moments. (AF)

  10. Vaevaline koostöö uute kunstimuuseumide rajamise ja rahastamise protsessis = Thorny collaboration in the processes of founding and funding new art museums : II koht teaduspublikatsioonide kategoorias / Margaret Tali, Laura Pierantoni

    Index Scriptorium Estoniae

    Tali, Margaret

    2009-01-01

    Uuring tutvustab võrdlevalt uute kunstimuuseumide rajamisega seotud motivatsioone kolmes riigis ning mahukate ehitusprojektide rahastamist, keskendudes uute huvigruppide rollile Ida-Euroopa riiklike kunstimuuseumide tegevuses. Töö andmed on kogutud koostöös kolme muuseumiga: LUMU kunstimuuseum Budapestis, KUMU kunstimuuseum Tallinnas ja MSU kunstimuuseum Zagrebis

  11. On the Image of Clown in the Master and Margaret from the Perspective of Clown′s Laughter%小丑的笑声--评《大师与马格丽特》中的小丑形象

    Institute of Scientific and Technical Information of China (English)

    杨苏红

    2005-01-01

    笑声是解读中的小丑形象的关键.巴赫金和布尔加科夫作为理论家和作家不约而同地将笑声看作是释放性的力量.在笑声中貌似神圣的一切被"脱冕",被"降格",恢复了平常的特性.

  12. The Reconstruction of an Idealist Academic Kingdom--A Review of Telling the Truth about History by Joyce Appleby, Lynn Hunt, Margaret Jacob%重建学术理想国--评《历史的真相》

    Institute of Scientific and Technical Information of China (English)

    周立红

    2003-01-01

    @@ 自20世纪六七十年代以来,美国历史学遭到来自两方面的挑战:一是主张"自下向上看"的新社会史异军突起,挖掘出了与正统美国史②众多相冲突的主题,使美国史呈现出支离破碎的状态;二是历史学的两大根基--科学性和现代性--受到后现代主义思潮的冲击,历史学的求真功能受到质疑.这两方面的挑战几乎同时发生,又具有一定的关联.于是,美国历史学处在了危机之中.由美国三位女历史学家合写的一书针对史学界的这一危机做出了反思,并在此基础上提出了重建学术理想国的具体设想.

  13. 撒切尔夫人的新自由主义实践:对工会的改革%Margaret Thatcher's Neo-liberal Practice: Reform of Trade Unions

    Institute of Scientific and Technical Information of China (English)

    钱箭星

    2010-01-01

    撒切尔政府奉行新自由主义的执政理念.为了治疗滞涨中的英国经济,撒切尔夫人大刀阔斧地推行工会改革,从法律上削弱工会的权利,放松对资本的限制,同时配合以私有化和福利制度改革.撒切尔革命取得的成效得到选民的认同,这个案例更多的启示在于对工会力量及其作用以及平衡劳资关系的认识.

  14. Some Enlightenments from Margaret Thatcher Government's Reform of Privatization%国企改革与竞争策略的运用--撒切尔政府私有化改革的一点启示

    Institute of Scientific and Technical Information of China (English)

    毛锐

    2006-01-01

    作为西方发达国家最典型的私有化案例,撒切尔政府私有化实践有许多宝贵的经验和教训值得吸取.在研究私有化时要注意中外学术界对私有化涵义的理解是有差异的,我们的学术界通常所理解的私有化只相当于西方狭义私有化的概念;加强竞争是当前提高国有企业效率的关键.

  15. 玛格丽特·德拉布尔小说《夏日鸟笼》中的身份诉求%The Search of Identity in Margaret Drabble' s A Summer Bird-cage

    Institute of Scientific and Technical Information of China (English)

    屈璟峰

    2013-01-01

    出版于1963年的第一部小说《夏日鸟笼》开启了玛格丽塔·德拉布尔的写作生涯.德拉布尔的第一个女主人公萨拉·贝内特是牛津毕业的高材生,却没有理想的工作.婚姻和职业的两难选择深深地困扰着知识女性,她们找不到自身的定位和身份.本文分析了萨拉面对的困境和对自己周围女性的观察反思来追寻自身身份的过程,指出女性身份诉求是没有终点的.

  16. Methods in Forest Canopy Research, Edited by Margaret D. Lowman, Timothy D. Schowalter, Jerry F. Franklin, University of California Press, 2012; 221 Pages. Price: £41.95, ISBN 978-0520-27371-9

    Directory of Open Access Journals (Sweden)

    Shu-Kun Lin

    2013-01-01

    Full Text Available Poised between soil and sky, forest canopies represent a critical point of exchange between the atmosphere and the earth, yet until recently, they remained a largely unexplored frontier. For a long time, problems with access and the lack of tools and methods suitable for monitoring these complex bioscopes made canopy analysis extremely difficult. Fortunately, canopy research has advanced dramatically in recent decades. Methods in Forest Canopy Research is a comprehensive overview of these developments for explorers of this astonishing environment. The authors describe methods for reaching the canopy and the best ways to measure how the canopy, atmosphere, and forest floor interact. They address how to replicate experiments in challenging environments and lay the groundwork for creating standardized measurements in the canopy — essential tools for understanding our changing world.

  17. Review: Margaret A. Morrison, Eric Haley, Kim Bartel Sheehan & Ronal E. Taylor (2002. Using Qualitative Research in Advertising: Strategies, Techniques, and Applications / Shay Sayre (2001. Qualitative Methods for Marketplace Research

    Directory of Open Access Journals (Sweden)

    Susanne Friese

    2004-01-01

    Full Text Available The review discusses two books, both covering very similar contents and addressing more or less the same audience. The book by SAYRE is about the use of qualitative method in marketplace research in general and is aimed at marketing students and practitioners; the book by MORRISON, HALEY, SHEEHAN and TAYLOR focuses more specifically on one area of mar­keting, namely advertising research. MORRISON et al. provide the more practical perspective, a fact that is also reflected in the writing style of the book. It is stimulating to read, even for readers fa­miliar with qualitative methods. It provides insights from the perspective of advertising agency plan­ners and demonstrates how qualitative methods are applied in a commercial context. SAYRE, in comparison, provides more details and builds her book around five theoretical perspectives. It is writ­ten by an academic for a largely academic audi­ence, containing all the basics that one needs to know when embarking on a qualitative research project. It differs from other qualitative method books in that the various steps along the way are illustrated by examples from the field of marketing. The book will, therefore, resonate well with mar­ket­ing students. Nonetheless, both books can be recommended as text books for qualitative method courses in marketing—SAYRE's book for market­ing students in general, and MORRISON et al.'s book for students specializing in the field of adver­tising. When used in a course where students conduct a small scale research project on their own, both books need to be supplemented by further readings or teacher input. Specifically, the sections on qualitative data analysis are too thin in MORRISON et al. and too broad in SAYRE in order to be useful to students without further explanation and training. Nonetheless, the two books are the best I have seen so far when it comes to selecting a book to be used in a qualitative method course for marketing students. URN: urn:nbn:de:0114-fqs0401258

  18. Leadership is Central to the Organizational Success of Libraries. A review of: Mullins, John, and Margaret Linehan. “The Central Role of Leaders in Public Libraries.” Library Management 26.6/7 (2005: 386‐96.

    Directory of Open Access Journals (Sweden)

    Pamela Haley

    2007-06-01

    Full Text Available Objective – To provide an understanding of the concept of leadership as perceived and practised by a group of international public library leaders, thereby contributing to the existing body of literature on this topic.Design – Qualitative study employing in depth, face‐to‐face interviews with 3 subjects and 27 e‐mail interviews based on 30 structured questions formulated from a review of the literature.Setting – Nottingham and Rotherham, two cities in the Public libraries in Ireland, Britain, and the east coast of the United States during 2003/04.Subjects – Thirty senior public library leaders.Methods – Thirty top level library leaders, 50% of whom came from outside Ireland, were selected based on the following rationale concerning their institutions: have a history of providing publicly funded public libraries; are under‐researched; and, accessibility for the authors. Irish librarians were chosen based on their national profile, geographic convenience to the researchers, and availability/cooperation. Only libraryl eaders or deputy leaders were considered. Interviews for 27 candidates where scheduled via e‐mail and 3 were arranged through face‐to‐face meetings. Participants were asked 30 structured questions drawn from the current literature on leadership. Responses were recorded electronically and later transcribed for analysis via a grounded theory approach that categorized the data. This method of analysis endeavours to provide theory based on research observations that begin from qualitative data and then go through a process of sifting and categorization, which leads to a hypothesis.Main results – Nine broad categories emerged from the “grounded theory analysis.” The paper deals with only 1 ‐ the central role of the library leader. In response to queries by the authors, 67% (20 agreed that leadership took precedence over all other factors as a determinant for organizational success. Ten (33% disagreed and were evenly split as to their reasons. Five said it was an important factor, and five felt leadership did not take precedence over other drivers of success. The study reveals that leaders do have an impact in determining organizational culture, with 63% saying the leader determines the culture, and 37% stating the leader only contributes to the culture of an organization. National cultural differences affect this point of view, for example 73% of the Irish public librarians, 60% of the British public librarians, and 40% of the American public librarians stated that it is the leader rather than the staff who determine organizational culture. Another core finding reveals that not all CEO's are leaders and not all librarians are leadership material, which points to the need for more classic leadership training.Conclusion – Based on the study's findings, the authors hypothesize that leadership is a central component in the strategic and operational practices and success of public librarianship. Transformational, rather than “leader centric” methods of leadership encourage growth of organizational change and success.

  19. Vaevaline koostöö uute kunstimuuseumide rajamise ja rahastamise protsessis = Thorny collaboration in the processes of founding and funding new art museums : II koht teaduspublikatsioonide kategoorias / Margaret Tali, Laura Pierantoni

    Index Scriptorium Estoniae

    Tali, Margaret

    2009-01-01

    Uuring tutvustab võrdlevalt uute kunstimuuseumide rajamisega seotud motivatsioone kolmes riigis ning mahukate ehitusprojektide rahastamist, keskendudes uute huvigruppide rollile Ida-Euroopa riiklike kunstimuuseumide tegevuses. Töö andmed on kogutud koostöös kolme muuseumiga: LUMU kunstimuuseum Budapestis, KUMU kunstimuuseum Tallinnas ja MSU kunstimuuseum Zagrebis

  20. War Without Borders: The Colombia-Ecuador Crisis of 2008

    Science.gov (United States)

    2008-12-01

    manipulating promotions among senior admirals of the Ecuadorean Navy. Minister of Defense Wellington Sandoval stated to El Comercio on March 30 that...elcomercio/imprima.asp?id_noticia=12031&medio=EC. See also Maite Rico, “Las FARC crean células clandestinas para su expansion internacional ” (“The...FARC Creates Clandestine Cells for International Expansion”), ELPAIS.com, downloaded May 20, 2008, www.elpais.com/articulo/ internacional /FARC/crean

  1. David Lynch Talks the Marvellous Creativity%一个美妙的头脑--电影制作者大卫·林奇谈奇妙的神秘创意

    Institute of Scientific and Technical Information of China (English)

    布莱特·西蒙; 游飞

    2003-01-01

    @@ 首先申明,这篇文章将不能命名为,它将避免依据众所周知的事实来对林奇的创作进行艺术化或个性化的阐释.毕竟,已经有太多的文章对大卫·林奇的个性怪僻、习惯和电影影像进行了过于繁琐细致的分类和盘查.因此:经常特异的装束(咔叽布的裤子、领口系扣的衬衫、休闲的佩饰)、瀑布般晃动的头发、独特的说话音色和热情而又大惊小怪的举止,一切都无需赘言.还有咖啡,事实上,在贝弗利山庄他的住宅兼工作室中与林奇见面,谈论这个当代文艺复兴人士的爱好和准则,就有点像是与一个老朋友见面一样.

  2. Curative effect of improved B-Lynch sutura on incurable postpartum haemorrhagia uterina%改良B-Lynch缝合术治疗产后难治性子宫出血疗效分析

    Institute of Scientific and Technical Information of China (English)

    胡立君

    2011-01-01

    目的:观察改良B-Lynch缝合术治疗产后难治性子宫出血的临床效果.方法:采用回顾性分析本院难治性产后子宫出血患者临床资料52例,按止血方法分为改良B-Lynch缝合组及对照组,比较两组患者止血成功率、子宫保留率、止血时间、术中出血量及术后24h阴道出血量.结果:两组患者均止血成功,止血成功率均为100%,改良B-Lynch缝合组子宫保留率高于对照组,改良B-Lynch缝合组止血时间短于对照组,术中出血量及术后24h阴道出血量少于对照组.结论:改良B-Lynch缝合治疗难治性子宫出血效果确切,具有较好的临床效果.

  3. Analysis on applied method in urban imago of Kevin Lynch%试析凯文·林奇在城市意象中采用的方法

    Institute of Scientific and Technical Information of China (English)

    王晓博; 窦维静

    2006-01-01

    凯文·林奇把城市作为研究对象,运用明晰的方法,将城市这一复杂综合体进行层层剖析,其本身散放着科学和理性的光芒,将城市意象中所采用的方法作为讨论主体,将有助于相关领域工作人员研究方法的提高.

  4. An Extensible and Scalable Framework for Formal Modeling, Analysis, and Development of Distributed Systems

    Science.gov (United States)

    2008-11-30

    the project personnel. All publications are available on request. [Pl| R. Canetti , L. Cheung, D. Kaynar, M. Liskov, N". Lynch, O. Pereira, and R...March 2008. [P2] Ran Canetti , Ling Cheung, Dilsun Kaynar, Nancy Lynch, and Oliviei Pereira. Modeling Bounded Computation in Long-Lived Systems. CONCUR...pages 153-1G2, 2001. [4] R. Canetti , L. Cheung. D. Kaynar, M. Liskov, N. Lynch, O. Pereirt, and R. Segala. Analyz- ing Security Protocol Using Thne

  5. Differential diagnosis of small bowel occlusions

    Directory of Open Access Journals (Sweden)

    Paolo Ghiringhelli

    2009-06-01

    Full Text Available Hereditary nonpolyposis colorectal cancer (HNPCC, also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, and microsatellite instability (MSI. Patients with Lynch syndrome have a markedly increased risk of colorectal cancer. We report a case of a 28-year-old male with Lynch syndrome; the case allows to describe clinical manifestations and diagnostic criteria of this syndrome, and to underline the importance of genetics in the diagnosis of this disease.

  6. Novel Structural Health Monitoring Schemes for Glass-Fiber Composites using Nanofillers

    Science.gov (United States)

    2014-03-31

    damage to CNT thin films ( Hou , Loh, and Lynch, 2007; Loh et al., 2009) and cementitious structures ( Hou and Lynch, 2009). Loyola et al. demonstrated...Keynote Speaker, the 36th Conference on Theoretical and Applied Mechanics, Chong Li, Taiwan, November 2012. • Distinguished Seminar Series Speaker, MAE... Hou , T. C., Loh, K. J., and Lynch, J. P., 2007. Spatial conductivity mapping of carbon nanotube composite thin films by electrical impedance

  7. 76 FR 11432 - Coding of Design Marks in Registrations

    Science.gov (United States)

    2011-03-02

    ... Classification''). DATES: Effective immediately. FOR FURTHER INFORMATION CONTACT: Cynthia C. Lynch, Office of the... search designations. Dated: February 24, 2011. David J. Kappos, Under Secretary of Commerce...

  8. 76 FR 60836 - Applicants

    Science.gov (United States)

    2011-09-30

    ... Transfer. Export Forwarders LLC (OFF), 3509 Vicky Circle, Kennesaw, GA 30144, Officers: David R. Ashford..., Officers: Robin Lynch, Managing Member (Qualifying Individual), Cutberto J. Parra Mendoza,...

  9. Pancreatic Cancer Early Detection Program

    Science.gov (United States)

    2014-07-30

    Pancreatic Cancer; Pancreas Cancer; Pancreatic Adenocarcinoma; Familial Pancreatic Cancer; BRCA 1/2; HNPCC; Lynch Syndrome; Hereditary Pancreatitis; FAMMM; Familial Atypical Multiple Mole Melanoma; Peutz Jeghers Syndrome

  10. Police Leadership and Management

    Directory of Open Access Journals (Sweden)

    Alan Beckley

    2015-03-01

    Full Text Available Book Review -- Police Leadership and Management by Margaret Mitchell and John Casey (editors, Federation Press, Sydney, 2007, 290 pages, ISBN 9781862876491, Reviewed by Alan Beckley

  11. 76 FR 72013 - Self-Regulatory Organizations; Municipal Securities Rulemaking Board; Notice of Filing of...

    Science.gov (United States)

    2011-11-21

    ... October 3, 2011 (``GFOA Letter''). \\5\\ See letter from Margaret C. Henry, General Counsel, Market... trade, to foster cooperation and coordination with persons engaged in regulating, clearing,...

  12. The Appearance of the Sun and Moon Seen Through Clouds

    Science.gov (United States)

    1993-12-01

    relevant conferences, I received valuable insight on my research from David Lynch , William Livingston, and others whose names I do not recall. I must...angular width. A remark by David Lynch at the 1993 Optical Society of America Topical Meeting on Light and Color in the Open Air that he had never seen a

  13. 76 FR 4554 - Notice of Establishment of the Wholesale Pork Reporting Negotiated Rulemaking Committee; Notice...

    Science.gov (United States)

    2011-01-26

    ... Avenue, St. Louis, Missouri 63105; Phone (314) 863-0400. FOR FURTHER INFORMATION CONTACT: Michael Lynch... (202) 720-6231; Fax (202) 690-3732; or e-mail at Michael.Lynch@ams.usda.gov . SUPPLEMENTARY INFORMATION... Negotiated Rulemaking Committee is in the public interest. Dated: January 21, 2011. David R....

  14. 76 FR 23513 - Wholesale Pork Reporting Negotiated Rulemaking Committee

    Science.gov (United States)

    2011-04-27

    ... (703) 684-7200. FOR FURTHER INFORMATION CONTACT: Michael Lynch, Chief; USDA, AMS, LS, LGMN Branch; 1400... at Michael.Lynch@ams.usda.gov . SUPPLEMENTARY INFORMATION: I. Background On September 28, 2010, the... Federal Register. Dated: April 22, 2011. David R. Shipman, Associate Administrator, Agricultural...

  15. 76 FR 55841 - Extension of Comment Period for Notice of Proposed Rulemaking on Changes in Requirements for...

    Science.gov (United States)

    2011-09-09

    ...-1451, attention Cynthia C. Lynch; by hand-delivery to the Trademark Assistance Center, Concourse Level, James Madison Building-East Wing, 600 Dulany Street, Alexandria, Virginia, attention Cynthia C. Lynch... comments until September 23, 2011. Dated: September 6, 2011. David J. Kappos, Under Secretary of...

  16. 78 FR 24747 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Science.gov (United States)

    2013-04-26

    ...-27-94, Thomas J. Lynch Trustee, St. Louis, Missouri; David Meiners, St. Louis, Missouri; Elizabeth H... Lesche Engler Fund (J. Curtis Engler), St. Louis, Missouri; David N. Flowers, Greenville, Illinois; Duane... and Marylyn J. Kirkham as Joint Tenants, both of Chesterfield, Missouri; Linda W. Lynch...

  17. Modes of Representation in Cognitive Mapping.

    Science.gov (United States)

    Cohen, Michelle E.; Nodine, Calvin F.

    Recent investigations of the cognitive components of human-environmental interactions owe much to the work of city planner Kevin Lynch, who hypothesized cognitive mapping as a two-way interactive process between individuals and their environment. Lynch identified five elements which individuals used in the construction of cognitive maps,…

  18. Effects of emotions on optimism bias and illusion of control in traffic.

    NARCIS (Netherlands)

    Mesken, J. Hagenzieker, M.P. & Rothengatter, T.

    2005-01-01

    Anger is related to aggression in traffic, which in turn may lead to risky driving (e.g. Lajunen, Parker & Stradling, 1998; Deffenbacher, Huff, Lynch, Oetting & Salvatore, 2000; Parker, Lajunen & Summa!a, 2002; Deffenbacher, Lynch, Filetti, Dahlen & Oetting, 2003). Anger may also lead directly to

  19. Factors Influencing Effectiveness of the Acquisition Career Field Initial Education Course

    Science.gov (United States)

    2006-03-01

    Design Method, New York, Wiley. Eisenberger, Robert; Cummings, Jim; Armeli, Stephen; Lynch, Patrick . (1997). “Perceived organizational support...305-312. Lynch, Patrick D.; Eisenberger, Robert; Armeli, Stephen. (1999). “Perceived organizational support: Inferior versus superior performance...Jum C. (1978) Psychometric Theory, New York, McGraw-Hill. Pillai , Rajnandini; Williams, Ethlyn A. (2004). “Transformational leadership, self

  20. Book Reviews

    Directory of Open Access Journals (Sweden)

    Joann Kovacich

    2013-09-01

    Osage, Patricia and McCall, Mary. Connecting with Socially Isolated Seniors: A Service Provider’s Guide Diane L. Brown Lynch, Caitrin. My Name is Julius: a film about growing old, staying young, and confronting a lifetime of hearing loss Lynch, Caitrin. Retirement on the Line : Age, Work, and Value in an American Factory Anne Velardi

  1. The MLH1 c.1852_1853delinsGC (p.K618A) Variant in Colorectal Cancer : Genetic Association Study in 18,723 Individuals

    NARCIS (Netherlands)

    Abuli, Anna; Bujanda, Luis; Munoz, Jenifer; Buch, Stephan; Schafmayer, Clemens; Maiorana, Maria Valeria; Veneroni, Silvia; van Wezel, Tom; Liu, Tao; Westers, Helga; Esteban-Jurado, Clara; Ocana, Teresa; Pique, Josep M.; Andreu, Montserrat; Jover, Rodrigo; Carracedo, Angel; Xicola, Rosa M.; Llor, Xavier; Castells, Antoni; Dunlop, Malcolm; Hofstra, Robert; Lindblom, Annika; Wijnen, Juul; Peterlongo, Paolo; Hampe, Jochen; Ruiz-Ponte, Clara; Castellvi-Bel, Sergi

    2014-01-01

    Colorectal cancer is one of the most frequent neoplasms and an important cause of mortality in the developed world. Mendelian syndromes account for about 5% of the total burden of CRC, being Lynch syndrome and familial adenomatous polyposis the most common forms. Lynch syndrome tumors develop mainly

  2. Information Operations in Iraq: The Mufsiddoon versus the U.S. and Coalition Forces

    Science.gov (United States)

    2008-04-01

    After firing the weapon, Zarqawi puts the weapon down and walks away to his truck wearing American made sneakers (Reeboks). Maj Gen Lynch points this...burning his hand and the comment by Gen Lynch that Zarqawi is wearing American sneakers drew a lot of laughter and played well in the Iraqi media.31

  3. 78 FR 5205 - Advice Concerning Possible Modifications to the U.S. Generalized System of Preferences, 2012...

    Science.gov (United States)

    2013-01-24

    ... Counsel (202-205-3091 or william.gearhart@usitc.gov ). The media should contact Margaret O'Laughlin, Office of External Relations (202-205-1819 or margaret.olaughlin@usitc.gov ). Hearing-impaired...); Brazil for HTS 7202.99.20 (calcium silicon ferroalloys); India for HTS 7307.21.50 (stainless steel, not...

  4. 78 FR 14590 - Advice Concerning Possible Modifications to the U.S. Generalized System of Preferences, 2012...

    Science.gov (United States)

    2013-03-06

    ... Counsel (202-205-3091 or william.gearhart@usitc.gov ). The media should contact Margaret O'Laughlin, Office of External Relations (202-205-1819 or margaret.olaughlin@usitc.gov ). Hearing-impaired... 7307.21.50) from India; Iron or steel (o/than stainless), not cast, flanges for tubes/ pipes, not...

  5. 77 FR 11589 - Advice Concerning Possible Modifications to the U.S. Generalized System of Preferences, 2011...

    Science.gov (United States)

    2012-02-27

    ...-205-3091 or william.gearhart@usitc.gov ). The media should contact Margaret O'Laughlin, Office of External Relations (202-205-1819 or margaret.olaughlin@usitc.gov ). Hearing-impaired individuals may obtain... preparations which operate by burning, to perfume or deodorize rooms or used during religious rites) from India...

  6. Memories of Fort Valley from 1938 to 1942

    Science.gov (United States)

    Frank H. Wadsworth

    2008-01-01

    This delightful essay records Frank Wadsworth's early forestry career at FVEF in the late 1930s. Frank married Margaret Pearson, G.A. and May Pearson's daughter, in 1941. Pearson believed Frank could not continue to work for him because of nepotism rules, so Frank and Margaret moved to San Juan, Puerto Rico in 1942 where Frank continued his forestry career....

  7. 77 FR 21995 - Trade Facilitation in the East African Community: Recent Developments and Potential Benefits...

    Science.gov (United States)

    2012-04-12

    ... ). The media should contact Margaret O'Laughlin, Office of External Relations (202-205-1819 or margaret... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE... agreements, such as those between the United States and the Philippines, the United States and Uruguay, and...

  8. Farvel til tegneserie-parlamentet

    DEFF Research Database (Denmark)

    Fejerskov, Adam Moe; Nissen, Christine

    2014-01-01

    Margaret Thatchers betegnelse af EU-Parlamentet som et ”Mickey Mouse”-parlament vil blive gjort til fortid med det kommende parlamentsvalg.......Margaret Thatchers betegnelse af EU-Parlamentet som et ”Mickey Mouse”-parlament vil blive gjort til fortid med det kommende parlamentsvalg....

  9. Thatcher

    DEFF Research Database (Denmark)

    Sevaldsen, Jørgen

    Biografi af Margaret Thatcher, britiske premierminister 1979-1990 og analyse af hendes projekt for ændring af det britiske samfund.......Biografi af Margaret Thatcher, britiske premierminister 1979-1990 og analyse af hendes projekt for ændring af det britiske samfund....

  10. Combined UGT1A1 and UGT1A6 genotypes together with a stressful life event increase breast cancer risk

    OpenAIRE

    2010-01-01

    Combined UGT1A1 and UGT1A6 genotypes together with a stressful life event increase breast cancer risk phone: +49-711-81015765 (Justenhoven, Christina) (Justenhoven, Christina) Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University Tuebingen - Auerbachstrasse 112 - 70376 - Stuttgart - GERMANY (Justenhoven, Christina) Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University Tuebingen - Auerbachstrasse 11...

  11. Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology.

    Science.gov (United States)

    Provenzale, Dawn; Gupta, Samir; Ahnen, Dennis J; Bray, Travis; Cannon, Jamie A; Cooper, Gregory; David, Donald S; Early, Dayna S; Erwin, Deborah; Ford, James M; Giardiello, Francis M; Grady, William; Halverson, Amy L; Hamilton, Stanley R; Hampel, Heather; Ismail, Mohammad K; Klapman, Jason B; Larson, David W; Lazenby, Audrey J; Lynch, Patrick M; Mayer, Robert J; Ness, Reid M; Regenbogen, Scott E; Samadder, Niloy Jewel; Shike, Moshe; Steinbach, Gideon; Weinberg, David; Dwyer, Mary; Darlow, Susan

    2016-08-01

    This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers.

  12. Dadá y el valor artístico de la obra de arte en el siglo XXI

    OpenAIRE

    Potau de la Muela, Luis Miguel

    2010-01-01

    Las diferentes guerras habidas en el siglo XX que han implicado a la mayoría de países del mundo provocaron que las corrientes culturales, artísticas, filosóficas y movimientos sociales tuvieran una recesión que en algunos aspectos crean nuevas formas de entender el arte. Un de estas creaciones surgidas tras la Primera Guerra Mundial es Dadá y su conceptualismo artístico que influye tanto en las técnicas artísticas como en la vida y concepción del arte de los creadores posteriores. Crean a pa...

  13. Historia del Pensamiento Político Premoderno 02 Grecia

    OpenAIRE

    Sanz Díaz, Benito (1949-)

    2010-01-01

    Tema 2 Grecia, la polis, el nacimiento del ciudadano. La Grecia Arcaica Hesiodo y el Mito en Grecia Grecia Clásica La Polis. Las ciudades-estado de la antigua Grecia.- ¿Cómo se crean las primeras polis? Sinecismo.- Las ciudades-estado de Grecia. ¿Cómo se crean las ciudades-estado? Las colonizaciones Atenas.- Dracón. Solón, sabio de Grecia. Clístenes. Pericles. Clases sociales en Atenas y las Polis: Ciudadanos. Metecos. Esclavos. ¿Cuáles eran las institucione...

  14. From Realistic Narrative to Apocalyptic Narrative-Synchronic Reinterpretation of Margaret Atwood's Fiction Limited in Diachronic Genre%从现实叙事到启示叙事——历时性视域下玛格丽特·阿特伍德长篇小说的共时性风格重释

    Institute of Scientific and Technical Information of China (English)

    王韵秋; 石梅芳

    2015-01-01

    国内外学者对玛格丽特·阿特伍德长篇小说风格的界定常常以共时性为主,本文认为这种共时性风貌只有在历时视域的拘囿之下才能更为恰当地呈现.1969-1995年间,她的小说风格因为反映了加拿大国内“主义(criticism)先于现实”的谬境,呈现出现实主义的特色.1995-2003年间,她的小说符应了历史变化,完成了与国际后现代浪潮对接,从而展示出具有“加拿大特色”的后现代主义风格.2013年,阿特伍德的最新作品《风颠亚当》(MaddAddam)问世.这不仅标志着其“反乌托邦三部曲”的结束,亦喻示她近十年来的叙事风格转向了以揭示“全球化”与“末日”关系为主的启示叙事(Apocalyptic Narrative).

  15. The Bio-accessibility of Synthetic Fe-Organo Complexes in Subsurface Soil with Elevated Temperature: a Proxy for the Vulnerability of Mineral Associated Carbon to Warming Rachel C. Porras, Peter S. Nico, and Margaret Torn Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA

    Science.gov (United States)

    Porras, R. C.; Hicks Pries, C.

    2015-12-01

    Globally, subsurface soils (>30 cm) represent an important reservoir of soil organic carbon (SOC). However, the vulnerability of this deep SOC and, in particular mineral-associated SOC, to warming, and its potential to amplify the effects of climate change is highly uncertain. To gain insight into the bio-accessibility and temperature sensitivity of mineral-associated organic C, we conducted a series of incubations using soils collected from three depths (0-10, 50-60, and 80-90 cm) under coniferous forest. The soils are moderately acidic (mean pH=6.5) sandy, mixed, mesic Ultic Haploxeralfs. To understand how mechanisms controlling SOC bio-accessibilty or temperature sensitivity differ with depth and with the properties of Fe-organo complexes (i.e.,degree of crystallinity, amount of reactive surface area, or surface saturation), we used a 13C labeled glucose substrate to prepare synthetic Fe-organo complexes spanning a range of crystallinity and mineral surface saturation. The synthetic Fe-organo complexes were then added to soil from three depths. The soils containing the 13C labeled Fe-organo adduct were incubated at two temperatures (ambient and +4°C) and respired 13CO2 was measured and used to estimate flux rates. Differences in measured 13CO2 fluxes as a function of depth, surface loading, and mineral properties are discussed in terms of their implications for the temperature sensitivity of mineral protected organic carbon in subsurface soils.

  16. Zika is not a reason for missing the Olympic Games in Rio de Janeiro: response to the open letter of Dr Attaran and colleagues to Dr Margaret Chan, Director - General, WHO, on the Zika threat to the Olympic and Paralympic Games

    Directory of Open Access Journals (Sweden)

    Claudia Codeço

    2016-06-01

    Full Text Available Attaran and colleagues in an open letter to WHO expressed their concern about the upcoming Olympic and Paralympic Games in Rio de Janeiro and the threat posed by the Zika epidemic (Attaran 2016. We agree that Zika virus is of great public health concern and much remains to be known about this disease. Care should be taken to reduce the risk of infection, especially to pregnant women. However, we argue that this is not sufficient reason for changing the original plans for the Games, in particular because of the time of the year when they will take place. The present article outlines several scientific results related to Zika and mosquito-borne infectious diseases dynamics that we believe ratify the current position of WHO in not endorsing the postponing or relocation of the 2016 Olympic and Paralympic Games (WHO 2016.

  17. Mère et fille - des relations en question, ou la liberté à tout prix : Isabel Allende, La casa de los espíritus ; Nicole Brossard, Le désert mauve ; Sarah Kofman, Rue Ordener, rue Labat ; Margaret Laurence, The diviners

    OpenAIRE

    2013-01-01

    The mother-daughter relationship is dual, ambivalent, a hall of mirrors; it is at once the site of the womb and maternity, a veritable matrix of meaning. The mother-daughter pairing moves through the body, constantly calling attention to its origins and valorising a transmission au féminin even from within a patriarchal society. However, it can also prove catastrophic. Though the mother is the first person with whom the daughter identifies—her first link to life—the daughter not only reacts t...

  18. Developing a fair use of resourcesThe recent British Medical Association report, Healthcare Funding Review ( BMA 2001 ), has thrown the issue of healthcare rationing into the spotlight again. Margaret Goodman looks at attempts to prioritise healthcare in other countries and draws lessons for the UK.

    Science.gov (United States)

    Goodman, Margaret

    2001-03-01

    The UK is not alone in facing increased pressures on health care within the context of finite resources. So is there is anything to be learned from the experiences of other countries and should their methods be adopted for the NHS?

  19. Pleasure, Fun and Flow

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    Through a life long commitment to urban design and urban planning, the legacy of American urban scholar Kevin Lynch is today influential in urban design practice as well as in education. In particular this paper will deal with the way Lynch discussed, saw and analysed the role of urban mobility...... of uninspiring and socially inactive sites for the contemporary mobile urbanite. However, the point about studying urban mobility through the perspective of Lynch is that we may realise that there are (or perhaps should be) other potentials and options. Thus there are two main points to be made in this paper...

  20. La distopía de las relaciones personales

    Directory of Open Access Journals (Sweden)

    Verónica Felipe Aznar

    2012-04-01

    Full Text Available Nada es real, pues nuestras experiencias no son reales sino meras reconstrucciones de la realidad generadas por nuestro cerebro. Vivimos en una virtualidad constante y, por ello, con la llegada de las nuevas tecnologías de la comunicación las relaciones interpersonales se trasladan al mundo virtual donde los usuarios crean su nueva forma de vida.

  1. Department of Defense Index of Specifications and Standards. Part 2. Numerical Listing

    Science.gov (United States)

    1993-07-01

    6530 / M 25-SEP-91 MD MS 03 A-A-5M96 BETAMETHASONE DIPROPIONATE CREAN. USP ..................................... A 6605 / U 30-SEP-91 M MS 03 A-A...A 7920 O 28-JAM-71 H-1-50A TOOTUSH (FOR RA.LTS AN CHILDREN ) USER: a. ............................ A 8530 S I15-SEP-72 H

  2. A Large-Scale Quantitative Proteomic Approach to Identifying Sulfur Mustard-Induced Protein Phosphorylation Cascades

    Science.gov (United States)

    2010-01-01

    P., Petrussevska, R. T., Breitkreutz, D., Hornung, J., Markham, A., and Fusenig, N. E. (1988) Normal keratinization in a spontaneously immortalized...Gabig, T. G., Mantel, P. L., Rosli, R., and Crean, C. D. (1994) Requiem: A novel zinc finger gene essential for apoptosis in myeloid cells. J. Biol

  3. Identificación y caracterización de los diseños Institucionales en la prestación del servicio de educación pública en la ciudad de Medellín : una aproximación desde la teoría de contratos y la economía del governance

    OpenAIRE

    Cano Zea, Mauricio; Gaviria López, Tomás

    2007-01-01

    En la teoría de contratos se agrupan las diferentes miradas de la teoría económica que analizan las transacciones desde una perspectiva contractual. Esta teoría percibe toda transacción como un contrato en el que se generan obligaciones y se crean o transfieren derechos.

  4. Identificación y caracterización de los diseños Institucionales en la prestación del servicio de educación pública en la ciudad de Medellín : una aproximación desde la teoría de contratos y la economía del governance

    OpenAIRE

    Cano Zea, Mauricio; Gaviria López, Tomás

    2007-01-01

    En la teoría de contratos se agrupan las diferentes miradas de la teoría económica que analizan las transacciones desde una perspectiva contractual. Esta teoría percibe toda transacción como un contrato en el que se generan obligaciones y se crean o transfieren derechos.

  5. B-LYNCH缝合术对前置胎盘产妇剖宫产止血效果及预后的影响%Effects of B-LYNCH sutura on hemostasis and prognosis of puerperae with placenta praevia after caesarean section

    Institute of Scientific and Technical Information of China (English)

    马秀英

    2016-01-01

    目的 探讨B-LYNCH缝合术及Bakri球囊对前置胎盘产妇剖宫产止血效果及预后影响的差异.方法 选择58例前置胎盘产妇为研究对象,随机分成A、B两组,各29例.B组予以Bakri球囊填塞方案,A组采用B-LYNCH缝合方案.对比两组产妇围产期各指标及预后指标差异;行为期12个月随访,比较两组产后并发症发生情况、性生活满意度及子宫切除情况.结果 (1)两组月经恢复时间、经量、月经周期等指标对比均无显著差异(P>0.05);但A组产妇平均术程、术中失血量、术后2h失血量、术后24h失血量、止血时间均显著低于B组(P<0.05);(2)随访中,两组均无子宫缺血、宫腔粘连等并发症发生;A组产后出血率为6.9%,显著低于B组的31.0%(P<0.05);(3)B组术后性生活满意度为65.5%,显著低于A组的93.1%(P<0.05);A组术后子宫切除率显著低于B组(P<0.05).结论 对行剖宫产的前置胎盘产妇予以B-LYNCH缝合方案,术中止血效果确切,可有效改善其术后性生活满意度,降低远期并发症发生风险,值得推广.

  6. 概念现象诠释凯文·林奇《城市意象》中的思维与概念%Concept, Phenomenon and Interpretation The Thinking and Concept of Kevin Lynch's The Image Of The City

    Institute of Scientific and Technical Information of China (English)

    李梦一欣

    2011-01-01

    文章以人思维中的"概念"为起点,从一个新的视角解读凯文·林奇的.通过"概念"表达思维的真实性,展现作者思辨的研究过程;从人的实际经验出发,利用现象而非言语演示概念,并与复杂的现实世界建立密切的联系;通过意象传达概念,在完成整个认知过程的同时达到与读者交流的目的;采用层层概念分步诠释,最终完成复杂概念的推演过程.同时在本文研究过程中明确了理性、真实的言语在"演示"中所起的关键作用.

  7. 验证凯文·林奇"形态核心价值标准理论"——以上海江湾-五角场地区为例%An Examination about Form Value Core Standards Theory from Kevin Lynch--A Case Study of Jiangwan-Wujiaochang Area,Shanghai

    Institute of Scientific and Technical Information of China (English)

    潘斌; 张剑涛; 周俭

    2008-01-01

    作者首先对美国凯文·林奇提出的"空间形态价值标准理论"推导思路与内容做出概述;然后通过调查、分析上海江湾-五角场地区空间形态规划制定及空间建成效果,对凯文·林奇的"形态价值标准理论"进行验证.结果显示,在上海江湾-五角场地区空间生成案例中,林奇的"核心价值标准理论"基本成立.

  8. Black Sex Myth and American Lynch: A Unique Perspective of James Baldwin's Anatomy on Racial Discrimination%黑人性神话与美国私刑——詹姆斯·鲍德温剖析种族歧视的独特视角

    Institute of Scientific and Technical Information of China (English)

    谭惠娟

    2007-01-01

    美国著名黑人作家詹姆斯·鲍德温从小缺乏家庭温暖和母爱,这导致了他成年后对性爱的畸形追求和不可自拔的迷恋,他因此每每注重从"性"的角度来观察和思考包括种族歧视在内的种种人生和社会问题.他认为白人对黑人滥施私刑乃至所有种族矛盾的根源,就在于白人对黑人性能力的恐惧;他还设想性爱可以成为化解种族冲突以及其他社会矛盾的良方,这构成了詹姆斯·鲍德温观察和思考种族歧视问题的独特视角和思路.这篇小说就集中体现了这种思想.

  9. Prokljatõje filmõ i dveri v nikuda / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2007-01-01

    Ameerika režissöör ja maalikunstnik David Lynch esineb 7. novembril kinos Kosmos loenguga "Film, Creativity and Consciousness". Ka filmist "Inland Empire". Eestisse kutsujateks olid Veiko Õunpuu, Rain Tolk ja Taavi Eelmaa

  10. Editorial

    OpenAIRE

    Zinchenko, Yury P.

    2016-01-01

    The current issue of “Psychology in Russia: State of the Art” provides the special section Mathematical learning: New perspectives and challenges, edited by Marina Vasilyeva, associate professor at Lynch School of Education, Boston College (USA).

  11. Metal-plaadid / Sergo Selder

    Index Scriptorium Estoniae

    Selder, Sergo

    2005-01-01

    Uutest heliplaatidest Deftones "B-Sides & Rarities", Metsatöll "Terast mis hangunud me hinge 10218", Horricane "The Lynch-Lawers", "Chimaira", Disturbed "Ten Thousand Fists", Iron Maiden "Death On The Road", Fear Factory "Transgression"

  12. Metal-plaadid / Sergo Selder

    Index Scriptorium Estoniae

    Selder, Sergo

    2005-01-01

    Uutest heliplaatidest Deftones "B-Sides & Rarities", Metsatöll "Terast mis hangunud me hinge 10218", Horricane "The Lynch-Lawers", "Chimaira", Disturbed "Ten Thousand Fists", Iron Maiden "Death On The Road", Fear Factory "Transgression"

  13. 78 FR 66937 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Science.gov (United States)

    2013-11-07

    ... Building Assistance for High Impact HIV Prevention, Funding Opportunity Announcement (FOA) PS14-1403... Impact HIV Prevention'' FOA PS14-1403. Contact Person for More Information: Harriette A. Lynch,...

  14. 77 FR 23 - Prohibitions and Restrictions on Proprietary Trading and Certain Interests in, and Relationships...

    Science.gov (United States)

    2012-01-03

    ... Associate Director, Division of Research and Statistics, (202) 452-3761; David Lynch, Manager, (202) 452... Sandoe, Senior Special Counsel, David Bloom, Branch Chief, or Angela Moudy, Attorney Advisor, Office...

  15. 77 FR 3745 - Establishment of a One-Year Retention Period for Trademark-Related Papers That Have Been Scanned...

    Science.gov (United States)

    2012-01-25

    .... Lynch, Office of the Deputy Commissioner for Trademark Examination Policy, by telephone at (571) 272... after submitting the request to verify entry of the requested changes. Dated: January 17, 2012. David...

  16. 78 FR 68488 - Self-Regulatory Organizations; NYSE MKT LLC; Notice of Filing of Proposed Rule Change Amending...

    Science.gov (United States)

    2013-11-14

    ... activity). \\14\\ See Calvin David Fox, 56 SE.C. 1371, 1376 (2003) (``With respect to a charge that conduct... business-related conduct. See also In the Matter of Merrill Lynch, Pierce, Fenner & Smith...

  17. 76 FR 60582 - Petition for Exemption; Summary of Petition Received

    Science.gov (United States)

    2011-09-29

    ...) 267-7626, or David Staples (202) 267-4058, Office of Rulemaking, Federal Aviation Administration, 800... Washington, DC, on September 23, 2011. Julie Ann Lynch, Acting Director, Office of Rulemaking. Petition...

  18. Culicidae (Diptera del arco sur de la Laguna de Mar Chiquita (Córdoba, Argentina y su importancia sanitaria Culicidae (Diptera from the southern coast of Mar Chiquita Lake (Cordoba, Argentina and their sanitary importance

    Directory of Open Access Journals (Sweden)

    Francisco Ludueña Almeida

    2004-12-01

    Full Text Available Se amplía la lista de veintidos especies de Culicidae citadas para el arco sur de la Laguna de Mar Chiquita a veintiocho. Aedeomyia squamipennis (Lynch Arribalzaga , Culex acharistus Root, Culex chidesteri Dyar, Haemagogus spegazzinii Brèthes, Mansonia titillans (Walker y Psorophora holmbergi Lynch Arribalzaga se citan por primera vez para la región. Se sintetizan los antecedentes relacionados con la importancia sanitaria de los culícidos de la zona.The list of twenty-two species of Culicidae from the southern coast of Mar Chiquita Lake is extended to twenty-eight. Aedeomyia squamipennis (Lynch Arribalzaga , Culex acharistus Root, Culex chidesteri Dyar, Haemagogus spegazzinii Brèthes , Mansonia titillans (Walker and Psorophora holmbergi Lynch Arribalzaga are listed for the first time for the region. The available information on sanitary importance of the culicids of the area is summarized.

  19. Järgmisel nädalal algab Veneetsia filmifestival / Andris Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Andris, 1982-

    2006-01-01

    Tänavune Veneetsia filmifestival toimub 30. augustist 9. septembrini. Kuldlõvile kandideerib 20 filmi, žüriid juhib Catherine Deneuve, elutööpreemia saab David Lynch. Festival algab Brian de Palma filmiga "Must daalia"

  20. Effects of seed fermentation method on seed germination and vigor ...

    African Journals Online (AJOL)

    BERTIN

    2013-11-27

    Nov 27, 2013 ... 3Plant Husbandry and Horticulture Unit, University of Liège - Gembloux Agro Bio Tech. Passage ... Central Africa (Bisognin, 2002; Enujiugha and Ayodele-. Oni, 2003). ... seed fermentation process (Harper and Lynch, 1980;.

  1. IN VITRO STUDY ON INHIBITION OF GLYCOSYLATION OF ...

    African Journals Online (AJOL)

    Administrator

    extract inhibits the binding of glucose to hemoglobin, since at higher concentration of glucose ... nonenzymatic glycosylation also occur in nucleic acids. In the later reaction ..... Raphael, S. S. (1983). Lynch's Medical Laboratory Technology 4th.

  2. Disease: H00543 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available Bergmann C, Fliegauf M, Bruchle NO, Frank V, Olbrich H, Kirschner J, Schermer B, Schmedding I, Kispert A, Kranzlin B, Nurnberg G, Bec...ker C, Grimm T, Girschick G, Lynch SA, Kelehan P, Sender

  3. Järgmisel nädalal algab Veneetsia filmifestival / Andris Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Andris, 1982-

    2006-01-01

    Tänavune Veneetsia filmifestival toimub 30. augustist 9. septembrini. Kuldlõvile kandideerib 20 filmi, žüriid juhib Catherine Deneuve, elutööpreemia saab David Lynch. Festival algab Brian de Palma filmiga "Must daalia"

  4. What Are the Risk Factors for Small Intestine Adenocarcinoma?

    Science.gov (United States)

    ... they are diagnosed is about 60. Smoking and alcohol use Some, but not all, studies have found ... is discussed more in Colorectal Cancer . Hereditary nonpolyposis colorectal cancer (HNPCC) Another name for HNPCC is Lynch syndrome . ...

  5. Prokljatõje filmõ i dveri v nikuda / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2007-01-01

    Ameerika režissöör ja maalikunstnik David Lynch esineb 7. novembril kinos Kosmos loenguga "Film, Creativity and Consciousness". Ka filmist "Inland Empire". Eestisse kutsujateks olid Veiko Õunpuu, Rain Tolk ja Taavi Eelmaa

  6. 75 FR 2853 - False Killer Whale Take Reduction Team Meeting

    Science.gov (United States)

    2010-01-19

    ...)(C) requires that members of TRTs have expertise regarding the conservation or biology of the marine... Lynch, Marine Mammal Commission; Paul Nachtigall, Hawaii Institute of Marine Biology; David Nichols... Meeting AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric...

  7. LALIGENS, Vol.4 (1), January 2015

    African Journals Online (AJOL)

    client

    2015-01-09

    Jan 9, 2015 ... Lynch and Mendelsohn (2014) posit that active listening is an ... features such as stress, intonation, rhythm, loudness and duration, which are absent ..... Finally, it encourages relaxation, using physical techniques and using.

  8. USGS contributions to earthquake and tsunami monitoring in the Caribbean Region

    Science.gov (United States)

    McNamara, D.; Caribbean Project Team, U.; Partners, C.

    2007-05-01

    USGS Caribbean Project Team: Lind Gee, Gary Gyure, John Derr, Jack Odum, John McMillan, David Carver, Jim Allen, Susan Rhea, Don Anderson, Harley Benz Caribbean Partners: Christa von Hillebrandt-Andrade-PRSN, Juan Payero ISU-UASD,DR, Eduardo Camacho - UPAN, Panama, Lloyd Lynch - SRU,Gonzalo Cruz - UNAH,Honduras, Margaret Wiggins-Grandison - Jamaica, Judy Thomas - CERO Barbados, Sylvan McIntyre - NADMA Grenada, E. Bermingham - STRI. The magnitude-9 Sumatra-Andaman Islands earthquake of December 26, 2004, increased global awareness of the destructive hazard posed by earthquakes and tsunamis. In response to this tragedy, the US government undertook a collaborative project to improve earthquake and tsunami monitoring along a major portion of vulnerable coastal regions, in the Caribbean Sea, the Gulf of Mexico, and the Atlantic Ocean. Seismically active areas of the Caribbean Sea region pose a tsunami risk for Caribbean islands, coastal areas along the Gulf of Mexico, and the Atlantic seaboard of North America. Nearly 100 tsunamis have been reported for the Caribbean region in the past 500 years, including 14 tsunamis reported in Puerto Rico and the U.S. Virgin Islands. Partners in this project include the United States Geological Survey (USGS), the Smithsonian Institute, the National Oceanic and Aeronautic Administration (NOAA), and several partner institutions in the Caribbean region. This presentation focuses on the deployment of nine broadband seismic stations to monitor earthquake activity in the Caribbean region that are affiliated with the Global Seismograph Network (GSN). By the end of 2006, five stations were transmitting data to the USGS National Earthquake Information Service (NEIS), and regional partners through Puerto Rico seismograph network (PRSN) Earthworm systems. The following stations are currently operating: SDDR - Sabaneta Dam Dominican Republic, BBGH - Gun Hill Barbados, GRGR - Grenville, Grenada, BCIP - Barro Colorado, Panama, TGUH - Tegucigalpa

  9. 78 FR 77687 - Science Advisory Board to the National Center for Toxicological Research; Notice of Meeting

    Science.gov (United States)

    2013-12-24

    ... Division of Microbiology Subcommittee and the Subcommittee Site Visit Report. Following the public session... special accommodations due to a disability, please contact Margaret Miller at least 7 days in advance...

  10. Kalendar nedeli : 4 - 10 nojabrja / Natalja Lesnaja

    Index Scriptorium Estoniae

    Lesnaja, Natalja

    1995-01-01

    Iz soderzh.: 6 nojab. 70 let so dnja rozhdenia Alberta Uustulnda; 8 nojab. 95 let so dnja rozhdenia Oskara Looritsa; 8 nojab. 95 let so dnja rozhdenia Margaret Mitshell; 9 nojab. 110 let so dnja rozhdenia Velimira Hlebnikova

  11. The STEM shortage paradox

    Science.gov (United States)

    Harris, Margaret

    2014-10-01

    The UK is believed to suffer from a shortage of scientists and engineers, yet unemployment rates for new graduates in these fields are high. Does that mean the skills shortage doesn't exist, asks Margaret Harris.

  12. Tackling conference carbon footprints

    Science.gov (United States)

    Grozier, Jim

    2016-12-01

    In reply to Margaret Harris's Lateral Thoughts article "Putting my foot down", which discussed the challenges of attending a conference with a physical disability (October p76) and a subsequent letter by Anna Wood (November p18).

  13. Peter Warry: 'managing conflict is a skill that Professor Warry will need in his new role'

    CERN Multimedia

    Goddard, A

    2001-01-01

    Peter Warry - former member of Department of Trade and Industry's deregulation task force, and special advisor to the Margaret Thatcher government - has been appointed chairman of the Particle Physics and Astronomy Research Council (1 paragraph).

  14. What Literature Says to Preservice Teachers and Teacher Educators.

    Science.gov (United States)

    Wear, Delese

    1989-01-01

    This article argues for the use of literary texts in teacher education. Discussed are John Updike's "Roger's Version" and Margaret Laurence's "A Jest of God," which illuminate two difficult problems facing teachers: intellectual paternalism and emotional distancing. (IAH)

  15. 76 FR 1191 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Science.gov (United States)

    2011-01-07

    ... information from public review, we cannot guarantee that we will be able to do so. J. Paul Loether, Chief..., 10001185 ] WISCONSIN Waukesha County Oliver, Own and Margaret, House, W 314 S 3986 SHWY 83,...

  16. Frank Gwazdauskas honored with the American Dairy Science Association Fellow Award

    OpenAIRE

    Greiner, Lori A.

    2008-01-01

    Frank C. Gwazdauskas of Blacksburg, Va., the David and Margaret Lincicome Professor in the Department of Dairy Science in Virginia Tech's College of Agriculture and Life Sciences, received the 2008 American Dairy Science Association (ADSA) Fellow Award.

  17. Hughes, Twain, Child, and Sanger: Four Who Locked Horns with the Censors

    Science.gov (United States)

    Meltzer, Milton

    1969-01-01

    A look at the lives and conflicts of four writers--Langston Hughes, Mark Twain, Lydia Maria Child, and Margaret Sanger--who faced public criticism and censorship because oftheir views on controversial issues. (RM)

  18. 31. VIII avati Vaala galeriis...

    Index Scriptorium Estoniae

    2004-01-01

    Näitus "Märkmed maalist. Eesti ja Leedu noor kunst". Kuraatorid Margaret Tali ja Milda Zvirblyte. Osalevad Maarit Murka, Tõnis Saadoja, Kristi Laanemäe, Vilius Vanagas, Agile Mazonaite, Jolanta Kyzikaite, Ieva Baranauskaite. Kõlab Taavi Laatsiti originaalmuusika

  19. NIGERIA - A TROPICAL COASTAL LOCATION

    African Journals Online (AJOL)

    2008-02-21

    Feb 21, 2008 ... “Department of Physics, University of Calabar, Calabar, Nigeria ... The characteristic pattern of rainfall in Calabar, a coastal - tropical location ... percentiles over most of Australia for ... meteorological records of the Margaret.

  20. 76 FR 35912 - Business Jet Aircraft Industry: Structure and Factors Affecting Competitiveness; Institution of...

    Science.gov (United States)

    2011-06-20

    ... william.gearhart@usitc.gov ). The media should contact Margaret O'Laughlin, Office of External Relations... competitiveness of the business jet aircraft industry in the United States, Brazil, Canada, Europe, and China. To...

  1. 78 FR 10692 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Science.gov (United States)

    2013-02-14

    ... ELLIS DENISE T GIBSON MARGARET JEAN GOULANDRIS PETER N HAUDENSCHILD ROBERT DANIEL HESS JOCELYN CAMPOS... MARSDEN DAPHNE JILL MAR-TANG SUE MASUDA TAKASHI MAYER-BIENVENU JESSICA S MILLMAN BARRY MOHR...

  2. Preemiad

    Index Scriptorium Estoniae

    2005-01-01

    Ervin Pütsepa preemia Karin Hallasele, Konrad Mäe medal Jaan Toomikule, Margaret Kevendi nimeline stipendium Maarja Niinemäele ja Rait Rosinale. Tokyo International Mini-Print Trienniali auhind Sirje Eelmale

  3. Naised poliitikas ja parem maailm / Iivi Masso

    Index Scriptorium Estoniae

    Masso, Iivi, 1967-

    2007-01-01

    Läänemaailma poliitika supernaistest: Suurbritannia endine peaminister Margaret Thatcher, USA välisminister Condoleezza Rice ja Saksamaa kantsler Angela Merkel. Põhjamaade naiste osalemisest poliitikas, näiteid Rootsi ja Soome poliitikast: Nyamko Sabuni, Tarja Halonen

  4. Thatcherism and British Higher Education.

    Science.gov (United States)

    Shattock, Michael

    1989-01-01

    A discussion of the influence of Britain's prime minister, Margaret Thatcher, on higher education looks at the relationship between the administrator's 10 years in office and the fiscal, educational, and public policy issues currently under debate. (MSE)

  5. Thatcher condemns attacks on abortion mp.

    Science.gov (United States)

    1987-12-19

    The Prime Minister, Mrs Margaret Thatcher, has stepped in to condemn a series of violent attacks on Liberal MP David Alton who is trying to reduce the [Illegible word] limit on abortions from 28 to 18 weeks.

  6. Thatcheri tütar avalikustas Raudse Leedi nõdrameelsuse / Sandra Maasalu

    Index Scriptorium Estoniae

    Maasalu, Sandra

    2008-01-01

    Ilmunud ka: Postimees : na russkom jazõke 26. aug. 2008, lk. 9. Suurbritannia endise peaministri Margaret Thatcheri tütar Carol Thatcher kirjutab peatselt ilmuvas mälestusteraamatus oma ema dementsusest

  7. [Not Available].

    Science.gov (United States)

    1991-10-16

    Local MP and former Prime Minister Margaret Thatcher had her finger on the button when demolition work was started on the site of the new Barnet General Hospital. She is pictured with nurse Mandy Larkins and her son Harry.

  8. Mõistke Thatcher Eesti pärast hukka!

    Index Scriptorium Estoniae

    2003-01-01

    Briti ekspeaminister Margaret Thatcher saatis Tallinnasse kirja soovitusega eestlastel kaaluda ühinemist EL-iga, mistõttu Eesti ühinemine EL-iga muutus kuumaks teemaks Briti alamkojas. Väljavõte arutelult alamkojas

  9. Maailmavaatest / Mart Laar

    Index Scriptorium Estoniae

    Laar, Mart, 1960-

    2008-01-01

    Autori hinnangul vajab Euroopa konservatiivset poliitikat, mis julgeb lähtuda selgetest põhimõtetest ning väärtustest. Sarnastest põhimõtetest on varem juhindunud Winston Churchill, Konrad Adenauer ja Margaret Thatcher

  10. Naisteromaanide uimarohi / Ilona Martson, Kristi Pärn

    Index Scriptorium Estoniae

    Martson, Ilona, 1970-

    1997-01-01

    Atwood, Margaret. Röövelpruut; Austen, Jane. Veenmine; Sheldon, Sidney. Veresidemed; Ondaatje, Michael. Inglise patsient; Lind, Hera. Kahe mehe vahel; Simmel, Johannes Mario. Vastust teab vaid tuul; Gaskin, Catherine. Fiona; Gaskin, Catherine. Perekonnaasjad; Barne, John. Evita

  11. Machines as the Measure of Women: Colonial Irony in a Cape to Cairo Automobile Journey, 1930

    National Research Council Canada - National Science Library

    Clarsen, Georgine

    2008-01-01

    ... identities at that inter-war moment. In that 1930 journey two South African women of English extraction, Margaret Belcher and Ellen Budgell, drove a second-hand Morris Oxford from their home in Cape Town, along the eastern side...

  12. Biographies of Eminent Women in Psychology: Models for Achievement.

    Science.gov (United States)

    Furumoto, Laurel; And Others

    1980-01-01

    In order to recognize women's contributions to the field of psychology, biographies of Margaret Floy Washburn, Mary Cover Jones, Karen Horney, Susan Grey, Edna Heidbreder, Ann Roe, and Mary Whitton Calkins are presented. (BEF)

  13. 75 FR 60126 - Performance Review Board Members

    Science.gov (United States)

    2010-09-29

    .... Haddix Amy B. Hall Anne E. Hall William H. Hall Thomas E. Hamilton John T. Hammarlund Mark Handelman.... Wright Stuart E. Wright Margaret M. Yanchuk Kevin S. Yeskey Robert Yetter Samir Zakhari Phyllis M. Zucker...

  14. Using the Stern Blocks.

    Science.gov (United States)

    Stern, Margaret

    1987-01-01

    Extracts from "Experimenting with Numbers" by Margaret Stern demonstrate the use of Stern Blocks to develop the conceptual base on which learning disabled students can build further mathematical skills. (DB)

  15. 31. VIII avati Vaala galeriis...

    Index Scriptorium Estoniae

    2004-01-01

    Näitus "Märkmed maalist. Eesti ja Leedu noor kunst". Kuraatorid Margaret Tali ja Milda Zvirblyte. Osalevad Maarit Murka, Tõnis Saadoja, Kristi Laanemäe, Vilius Vanagas, Agile Mazonaite, Jolanta Kyzikaite, Ieva Baranauskaite. Kõlab Taavi Laatsiti originaalmuusika

  16. Veje og udveje i et felt under forandring

    DEFF Research Database (Denmark)

    Steensen, Jette Johanne Elisabeth

    , hvor skolen og uddannelsessystemet er under af/eller udvikling. Det teoretiske begrebsapprarat hentes hos den franske sociolog Pierre Bourdieu og den engelsk sociolog Margaret Archer. Afhandlingen foretager en konsekvent gennemarbejdning af forholdet mellem teori, videnskabsteori og metode, som munder...

  17. Epidemiology of infertility: social problems of the infertile couples

    African Journals Online (AJOL)

    Epidemiology of infertility: social problems of the infertile couples. Margaret .... imbalance in the power relations between men and women to such an .... India in 1993, the African Academy of Sciences issued a dissent- ..... York: Plenum Press.

  18. Naisteromaanide uimarohi / Ilona Martson, Kristi Pärn

    Index Scriptorium Estoniae

    Martson, Ilona, 1970-

    1997-01-01

    Atwood, Margaret. Röövelpruut; Austen, Jane. Veenmine; Sheldon, Sidney. Veresidemed; Ondaatje, Michael. Inglise patsient; Lind, Hera. Kahe mehe vahel; Simmel, Johannes Mario. Vastust teab vaid tuul; Gaskin, Catherine. Fiona; Gaskin, Catherine. Perekonnaasjad; Barne, John. Evita

  19. Tailbone Pain: How Can I Relieve It?

    Science.gov (United States)

    ... causes tailbone pain, and how can I ease it? Answers from Margaret Moutvic, M.D. Tailbone pain — pain that occurs in ... called coccydynia or coccygodynia, usually goes away on its own within a few weeks or months. To ...

  20. 75 FR 48337 - Change in Bank Control Notices; Acquisition of Shares of Bank or Bank Holding Companies

    Science.gov (United States)

    2010-08-10

    ..., individually, and as part of a group acting in concert with Dick and Margaret Anderson, FLP; Dick Anderson Construction, Inc.; Dick Anderson Construction Profit Sharing Plan & Trust; MA Construction, Inc., (fka...