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Sample records for lymphoma marginal zone

  1. Extranodal marginal zone (MALT) lymphoma in common variable immunodeficiency.

    NARCIS (Netherlands)

    Desar, I.M.; Keuter, M.; Raemaekers, J.M.M.; Jansen, J.B.M.J.; Krieken, J.H.J.M. van; Meer, J.W.M. van der

    2006-01-01

    We describe two patients with common variable immunodeficiency (CVID) who developed extranodal marginal zone lymphoma (formerly described as mucosa-associated lymphoid tissue lymphoma or MALT lymphoma). One patient, with documented pernicious anaemia and chronic atrophic gastritis with metaplasia, d

  2. Pathogenesis of splenic marginal zone lymphoma

    Directory of Open Access Journals (Sweden)

    Ming-Qing Du

    2015-11-01

    Full Text Available Splenic marginal zone lymphoma (SMZL is a distinct low grade B-cell lymphoma with an immunophenotype similar to that of splenic marginal zone B-cells. Like the normal splenic marginal zone B-cells, SMZLs also show variable features in somatic mutations of their rearranged immunoglobulin genes, with ∼90% of cases harbouring somatic mutations but at remarkably variable degrees, suggesting that SMZL may have multiple cell of origins, deriving from the heterogeneous B-cells of the splenic marginal zone. Notably, ∼30% of SMZLs show biased usage of IGHV1-2*04, with the expressed BCR being potentially polyreactive to autoantigens. Recent exome and targeted sequencing studies have identified a wide spectrum of somatic mutations in SMZL with the recurrent mutations targeting multiple signalling pathways that govern the development of splenic marginal zone B-cells. These recurrent mutations occur in KLF2 (20–42%, NOTCH2 (6.5–25%, NF-κB (CARD11 ∼7%, IKBKB ∼7%, TNFAIP3 7–13%, TRAF3 5%, BIRC3 6.3% and TLR (MYD88 5–13% signalling pathways. Interestingly, the majority of SMZL with KLF2 mutation have both 7q32 deletion and IGHV1-2 rearrangement, and these cases also have additional mutations in NOTCH2, or TNFAIP3, or TRAF3. There is a potential oncogenic cooperation among concurrent genetic changes, for example between the IGHV1-2 expressing BCR and KLF2 mutation in activation of the canonical NF-κB pathway, and between KLF2 and TRAF3 mutations in activation of the non-canonical NF-κB pathway. These novel genetic findings have provided considerable insights into the pathogenesis of SMZL and will stimulate the research in both normal and malignant marginal zone B-cells.

  3. The genetics of nodal marginal zone lymphoma.

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    Spina, Valeria; Khiabanian, Hossein; Messina, Monica; Monti, Sara; Cascione, Luciano; Bruscaggin, Alessio; Spaccarotella, Elisa; Holmes, Antony B; Arcaini, Luca; Lucioni, Marco; Tabbò, Fabrizio; Zairis, Sakellarios; Diop, Fary; Cerri, Michaela; Chiaretti, Sabina; Marasca, Roberto; Ponzoni, Maurilio; Deaglio, Silvia; Ramponi, Antonio; Tiacci, Enrico; Pasqualucci, Laura; Paulli, Marco; Falini, Brunangelo; Inghirami, Giorgio; Bertoni, Francesco; Foà, Robin; Rabadan, Raul; Gaidano, Gianluca; Rossi, Davide

    2016-09-08

    Nodal marginal zone lymphoma (NMZL) is a rare, indolent B-cell tumor that is distinguished from splenic marginal zone lymphoma (SMZL) by the different pattern of dissemination. NMZL still lacks distinct markers and remains orphan of specific cancer gene lesions. By combining whole-exome sequencing, targeted sequencing of tumor-related genes, whole-transcriptome sequencing, and high-resolution single nucleotide polymorphism array analysis, we aimed at disclosing the pathways that are molecularly deregulated in NMZL and we compare the molecular profile of NMZL with that of SMZL. These analyses identified a distinctive pattern of nonsilent somatic lesions in NMZL. In 35 NMZL patients, 41 genes were found recurrently affected in ≥3 (9%) cases, including highly prevalent molecular lesions of MLL2 (also known as KMT2D; 34%), PTPRD (20%), NOTCH2 (20%), and KLF2 (17%). Mutations of PTPRD, a receptor-type protein tyrosine phosphatase regulating cell growth, were enriched in NMZL across mature B-cell tumors, functionally caused the loss of the phosphatase activity of PTPRD, and were associated with cell-cycle transcriptional program deregulation and increased proliferation index in NMZL. Although NMZL shared with SMZL a common mutation profile, NMZL harbored PTPRD lesions that were otherwise absent in SMZL. Collectively, these findings provide new insights into the genetics of NMZL, identify PTPRD lesions as a novel marker for this lymphoma across mature B-cell tumors, and support the distinction of NMZL as an independent clinicopathologic entity within the current lymphoma classification. © 2016 by The American Society of Hematology.

  4. Primary marginal zone B-cell lymphoma of appendix

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    Radha S

    2008-07-01

    Full Text Available Primary lymphomas of appendix are extremely rare tumors. The first case of primary lymphoma of appendix was reported by Warren in the year 1898. Incidence of primary lymphoma of appendix is 0.015% of all gastrointestinal lymphomas. This is a report of primary marginal zone B-cell lymphoma of appendix which presented as appendicular mass. As some cases are incidentally discovered, this case emphasizes that histological examination of all appendicectomy specimens is mandatory.

  5. FISH analysis of MALT lymphoma-specific translocations and aneuploidy in primary cutaneous marginal zone lymphoma.

    NARCIS (Netherlands)

    Schreuder, M.I.; Hoefnagel, J.J.; Jansen, P.A.M.; Krieken, J.H.J.M. van; Willemze, R.; Hebeda, K.M.

    2005-01-01

    Primary cutaneous marginal zone lymphomas (PCMZL) share histological and clinical characteristics with mucosa-associated lymphoid tissue (MALT) lymphomas suggesting a common pathogenesis. A number of recurrent structural and numerical chromosomal aberrations have been described in MALT lymphoma, but

  6. FISH analysis of MALT lymphoma-specific translocations and aneuploidy in primary cutaneous marginal zone lymphoma.

    NARCIS (Netherlands)

    Schreuder, M.I.; Hoefnagel, J.J.; Jansen, P.A.M.; Krieken, J.H.J.M. van; Willemze, R.; Hebeda, K.M.

    2005-01-01

    Primary cutaneous marginal zone lymphomas (PCMZL) share histological and clinical characteristics with mucosa-associated lymphoid tissue (MALT) lymphomas suggesting a common pathogenesis. A number of recurrent structural and numerical chromosomal aberrations have been described in MALT lymphoma, but

  7. Long-term outcome for gastric marginal zone lymphoma treated with radiotherapy

    DEFF Research Database (Denmark)

    Wirth, A; Gospodarowicz, M; Aleman, B M P;

    2013-01-01

    We evaluated the long-term results of radiotherapy for patients with gastric marginal zone lymphoma (GMZL).......We evaluated the long-term results of radiotherapy for patients with gastric marginal zone lymphoma (GMZL)....

  8. Marginal Zone Lymphoma Complicated by Protein Losing Enteropathy

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    Nadine Stanek

    2016-01-01

    Full Text Available Protein losing enteropathy (PLE refers to excessive intestinal protein loss, resulting in hypoalbuminemia. Underlying pathologies include conditions leading to either reduced intestinal barrier or lymphatic congestion. We describe the case of a patient with long-lasting diffuse abdominal problems and PLE. Repetitive endoscopies were normal with only minimal lymphangiectasia in biopsies. Further evaluations revealed an indolent marginal zone lymphoma with minor bone marrow infiltration. Monotherapy with rituximab decreased bone marrow infiltration of the lymphoma but did not relieve PLE. Additional treatments with steroids, octreotide, a diet devoid of long-chain fatty-acids, and parenteral nutrition did not prevent further clinical deterioration with marked weight loss (23 kg, further reduction in albumin concentrations (nadir 8 g/L, and a pronounced drop in performance status. Finally, immunochemotherapy with rituximab and bendamustine resulted in hematological remission and remarkable clinical improvement. 18 months after therapy the patient remains free of gastrointestinal complaints and has regained his body weight with normal albumin levels. We demonstrate a case of PLE secondary to indolent marginal zone lymphoma. No intestinal pathologies were detected, contrasting a severe and almost lethal clinical course. Immunochemotherapy relieved lymphoma and PLE, suggesting that a high suspicion of lymphoma is warranted in otherwise unexplained cases of PLE.

  9. Recidiva tardia de linfoma da zona marginal Late relapse of marginal zone lymphoma

    OpenAIRE

    Rocha,Talita M. B.S.; Bortolheiro,Tereza C.; Eduardo Costa; Daniela Haardt; Roberto P. Paes; Chiattone, Carlos S.

    2009-01-01

    O linfoma de zona marginal é um linfoma de baixo grau com curso clínico indolente e potencial de recidiva.1,2 Apresentamos um caso de recidiva tardia após 25 anos de aparente remissão completa, levantando a possibilidade de recidiva de doença preexistente ou desenvolvimento de novo clone neoplásico.Marginal zone lymphoma is a low grade lymphoma with an indolent course and chance to relapse. We present a case of a patient who suffered relapse after 25 years of apparently complete remission of ...

  10. Emerging role of infectious etiologies in the pathogenesis of marginal zone B-cell lymphomas.

    Science.gov (United States)

    Zucca, Emanuele; Bertoni, Francesco; Vannata, Barbara; Cavalli, Franco

    2014-10-15

    Extranodal marginal zone B-cell lymphomas of the mucosa-associated lymphoid tissue (MALT) arise from lymphoid populations that are induced by chronic inflammation in extranodal sites. The most frequently affected organ is the stomach, where MALT lymphoma is incontrovertibly associated with a chronic gastritis induced by a microbial pathogen, Helicobacter pylori. Gastric MALT lymphoma therefore represents a paradigm for evaluating inflammation-associated lymphomagenesis, which may lead to a deeper understanding of a possible etiologic association between other microorganisms and nongastric marginal zone lymphomas. Besides infectious etiology, chronic inflammation caused by autoimmune diseases, such as Sjögren syndrome or Hashimoto thyroiditis, can also carry a significant risk factor for the development of marginal zone lymphoma. In addition to the continuous antigenic drive, additional oncogenic events play a relevant role in lymphoma growth and progression to the point at which the lymphoproliferative process may eventually become independent of antigenic stimulation. Recent studies on MALT lymphomas have in fact demonstrated genetic alterations affecting the NF-κB) pathway, a major signaling pathway involved in many cancers. This review aims to present marginal zone lymphoma as an example of the close pathogenetic link between chronic inflammation and tumor development, with particular attention to the role of infectious agents and the integration of these observations into everyday clinical practice. See all articles in this CCR Focus section, "Paradigm Shifts in Lymphoma."

  11. Primary cutaneous marginal zone B-cell lymphoma: clinical and therapeutic features in 50 cases.

    NARCIS (Netherlands)

    Hoefnagel, J.J.; Vermeer, M.H.; Jansen, P.A.M.; Heule, F.; Voorst Vader, P.C. van; Sanders, C.J.; Gerritsen, M.J.P.; Geerts, M.L.; Meijer, C.J.; Noordijk, E.M.; Willemze, R.

    2005-01-01

    BACKGROUND: Primary cutaneous marginal zone B-cell lymphoma (PCMZL) is a low-grade B-cell lymphoma that originates in the skin, with no evidence of extracutaneous disease. Studies focusing on the optimal treatment of PCMZL have not been published thus far. We describe 50 patients with PCMZL to

  12. Primary cutaneous marginal zone B-cell lymphoma: Clinical and therapeutic features in 50 cases

    NARCIS (Netherlands)

    P.P.W. Hoefnagel (Pepijn); P.M. Noordijk (P.); R. Willemze (Roelof); M.H. Vermeer (Maarten); P.M. Jansen (Pieter); F. Heule (Freerk); P.C. Van Voorst Vader (P.); C.J.G. Sanders (C. J G); M.J.P. Gerritsen (M. J P); M.L. Geerts (M.); C.J.L.M. Meijer (Chris)

    2005-01-01

    textabstractBackground: Primary cutaneous marginal zone B-cell lymphoma (PCMZL) is a low-grade B-cell lymphoma that originates in the skin, with no evidence of extracutaneous disease. Studies focusing on the optimal treatment of PCMZL have not been published thus far. We describe 50 patients with

  13. Primary cutaneous marginal zone B-cell lymphoma - Clinical and therapeutic features in 50 cases

    NARCIS (Netherlands)

    Hoefnagel, JJ; Vermeer, MH; Jansen, PM; Heule, F; Vader, PCV; Sanders, CJG; Gerritsen, MJP; Geerts, ML; Meijer, CJLM; Noordijk, EM; Willemze, R

    Background: Primary cutaneous marginal zone B-cell lymphoma (PCMZL) is a low-grade B-cell lymphoma that originates in the skin, with no evidence of extracutaneous disease. Studies focusing on the optimal treatment of PCMZL have not been published thus far. We describe 50 patients with PCMZL to

  14. Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

    NARCIS (Netherlands)

    R.J. Bende; F. van Maldegem; C.J.M. van Noesel

    2009-01-01

    Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis;

  15. Primary gastric T cell lymphoma mimicking marginal zone B cell lymphoma of mucosa-associated lymphoid tissue.

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    Holanda, Danniele; Zhao, Merry Y; Rapoport, Aaron P; Garofalo, Michael; Chen, Qing; Zhao, X Frank

    2008-07-01

    Primary gastric T cell lymphoma is rare and mostly of large cell type. In this paper, we present a case of gastric T cell lymphoma morphologically similar to the gastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT). Morphologically, the cells are small with abundant clear cytoplasm. Lymphoepithelial lesions are readily identified with diffuse destruction of gastric glands. Immunohistochemically, the neoplastic cells are CD3+/CD4+/CD8-/Granzyme B-. Molecular studies revealed monoclonal T cell receptor gamma gene rearrangement. Clinically, the patient responded initially to four cycles of R-CHOP, but then progressed. Because peripheral T cell lymphoma is usually associated with a poor prognosis, whereas marginal zone B cell lymphoma is an indolent lymphoproliferative disorder, this morphologic mimicry should be recognized and completely investigated when atypical small lymphoid infiltrates with lymphoepithelial lesions are encountered in the stomach.

  16. Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)

    Science.gov (United States)

    2017-10-05

    B-Cell Chronic Lymphocytic Leukemia; Monoclonal B-Cell Lymphocytosis; Lymhoma, Small Lymphocytic; Chronic Lymphocytic Leukemia; Lymphoplasmacytic Lymphoma; Waldenstrom Macroglobulinemia; Splenic Marginal Zone Lymphoma

  17. A Phase 2 Study of Concurrent Fludarabine and Rituximab for the Treatment of Marginal Zone Lymphomas

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    Brown, Jennifer R; Friedberg, Jonathan W.; Feng, Yang; Scofield, Sarah; Phillips, Kimberly; Cin, Paola Dal; Joyce, Robin; Takvorian, Ronald W; Fisher, David C; Fisher, Richard I; Liesveld, Jane; Marquis, Diana; Neuberg, Donna; Freedman, Arnold S

    2009-01-01

    SUMMARY The marginal zone lymphomas are a recently defined group of related diseases likely arising from a common cell of origin, the marginal zone B cell. Data on therapy for subtypes other than gastric MALT has been largely limited to retrospective case series. We therefore undertook this prospective phase 2 study of fludarabine and rituximab for the treatment of marginal zone lymphomas. 26 patients were enrolled, 14 with nodal MZL, 8 with MALT lymphomas and 4 with splenic MZL; 81% were receiving initial systemic therapy. Only 58% (95% CI 37–77%) of patients completed the planned six cycles, due to significant hematologic, infectious and allergic toxicity. Four late toxic deaths occurred due to infections (15% (95% CI 4.3–35%), two related to delayed bone marrow aplasia and two related to MDS. Nonetheless, the ORR was 85% (95% CI 65–96%), with 54% CRs. The progression-free survival at 3.1 years of follow-up is 79.5% (95% CI, 63–96%). We conclude that although concurrent fludarabine and rituximab given at this dose and schedule is a highly effective regimen in the treatment of marginal zone lymphomas, the significant hematologic and infectious toxicity observed both during and after therapy is prohibitive in this patient population, emphasizing the need to study marginal zone lymphomas as a separate entity. PMID:19344412

  18. Splenic marginal zone lymphoma with Evans' syndrome, autoimmunity, and peripheral gamma/delta T cells

    OpenAIRE

    2008-01-01

    Splenic marginal zone lymphoma with Evans? syndrome, autoimmunity, and peripheral gamma/delta T cells (Garcia-Mu?oz, Ricardo) Hematology Service, Clinica Universitaria, University of Navarra - Pamplona - SPAIN (Garcia-Mu?oz, Ricardo) Hematology Service, Clinica Universitaria, University of Navarra - Pamplona - SPAIN (Rodriguez-Otero, Paula) Hematology Service, Clinica Universitaria, University of Navarra - Pamplona - SPAIN (Pegenaute, Carlota) Department of...

  19. Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma

    KAUST Repository

    Zibellini, S.

    2010-05-29

    Antigen stimulation may be important for splenic marginal zone lymphoma pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases. Sixteen SMZL (12%) showed stereotyped BCR; 7 of 86 (8%) SMZL sequences retrieved from public databases also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified: i) SMZL-specific subsets (n=5), composed only of 12 SMZL (9 HCV- from our series); ii) Non-Hodgkin\\'s lymphoma-like subsets (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; iii) "CLL-like subsets" (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of splenic marginal zone lymphoma may involve also HCV unrelated epitopes or an antigenic trigger common to other indolent lymphomas. ©2010 Ferrata Storti Foundation.

  20. FOXP1 status in splenic marginal zone lymphoma: a fluorescence in situ hybridization and immunohistochemistry approach.

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    Baró, Cristina; Espinet, Blanca; Salido, Marta; Colomo, Lluís; Luño, Elisa; Florensa, Lourdes; Ferrer, Ana; Salar, Antonio; Campo, Elias; Serrano, Sergi; Solé, Francesc

    2009-11-01

    Splenic marginal zone lymphoma (SMZL) is a well-recognized entity in which chromosomal aberrations seem to be potential markers in diagnosis, prognosis and disease monitoring. FOXP1 is a transcriptional regulator of B lymphopoiesis that is deregulated in some types of NHL. Translocation t(3;14)(p14;q32) has been described in marginal zone lymphomas but few series have studied FOXP1 involvement in SMZL. We performed cytogenetic, fluorescence in situ hybridization (FISH) and immunohistochemical (IHC) studies in a series of 36 patients in order to study the status of FOXP1 in this entity. According to our results, FOXP1 is not rearranged in SMZL, although we were able to demonstrate gains of FOXP1 gene due to trisomy 3/3p by FISH. FOXP1 protein expression seemed to be not related to any aberration and IHC studies are not conclusive.

  1. Primary Hepatic Marginal Zone Lymphoma in a Patient with Chronic Hepatitis C.

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    Gherlan, George S; Stoia, Razvan; Enyedi, Mihaly; Dobrea, Camelia; Calistru, Petre I

    2016-09-01

    Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) is a low-grade malignant lymphoma that appears frequently in the stomach, but other sites can also be involved: the intestinal tract, lungs, head, neck, skin, thyroid, breasts and liver. Recently, epidemiological evidences support the idea that there is an association between hepatitis C and B-cell non-Hodgkin lymphomas (that include MALT as a subtype). Primary non-Hodgkin lymphomas confi ned only to the liver are very rare (only 0.016% of all cases of all non-Hodgkin's lymphomas) and MALT is not the most frequent type. We present the case of a male patient, age 62, known with chronic hepatitis C, previously relapser a" er a 72 week treatment with peg-interferon alfa and ribavirin that was diagnosed at three years a" er the relapse with multiple focal liver lesions. One of the tumors was surgically removed and the histological exam performed demonstrated an extranodal marginal zone lymphoma with small B-cell with plasmacytoid diff erentiation confi ned only to the liver. Direct acting antiviral (DAA) therapy was started, but the virologic clearance was not obtained by week 10, leading to a change of DAA regimen at week 12. The antiviral therapy was continued until week 24. Imaging showed an increase in number and size of the focal lesions until week 12. At week 12 chemo- and immune-therapy was started with bendamustine and rituximab. A" erwards the evolution was favorable, the patient being now in complete remission and with undetectable viral load.

  2. Extranodal Marginal Zone Lymphoma Presenting within the Meckel Diverticulum as Diverticulitis: A Case Report

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    A. Nael

    2014-01-01

    Full Text Available Meckel diverticulum is the most common congenital defect of the gastrointestinal tract. It can be asymptomatic or mimic appendicitis and may be complicated by bleeding, diverticulitis, obstruction, and, rarely, neoplasia. We report the first case of extranodal marginal zone lymphoma occupying a Meckel diverticulum. A 44-year-old man with history of colonic diverticulitis presented to the emergency department for evaluation of acute abdominal pain. Radiography showed enteric obstruction, prompting diagnostic laparoscopy. Above the level of mid-ileum an intact Meckel diverticulum was identified. Microscopy showed extensive infiltration of sheets of small lymphocytes with abundant cytoplasm (monocytoid B-cells prominently in submucosa and focally transmural involving serosal adipose tissue with multiple reactive germinal centers. The immunostains showed positivity for CD20, BCL-2, and CD43 (weak and negativity for CD3, CD5, BCL-1, CD10, and BCL-6 in monocytoid B-cells. Fluorescence in situ hybridization studies revealed API2-MALT1 fusion signals consistent with t(11;18(q21;q21, which confirmed the diagnosis of extranodal marginal zone lymphoma, also known as mucosa associated lymphoid tissue lymphoma.

  3. Evans Syndrome Presented with Marginal Zone Lymphoma and Duodenal Neuroendocrine Tumor in an Elderly Woman

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    Daniele D'Ambrosio

    2016-12-01

    Full Text Available Evans syndrome (ES is an autoimmune disorder characterized by simultaneous or sequential development of autoimmune hemolytic anemia, immune thrombocytopenia, and/or neutropenia. ES can be classified as a primary (idiopathic or secondary (associated with an underlying disease syndrome. We report a case of ES in an elderly patient in the presence of multiple trigger factors such as recent influenza vaccine, marginal zone lymphoma, and neuroendocrine tumor G1. Whether this association is casual or causal remains a matter of speculation. It is however necessary to have a thorough work-up in a newly diagnosed ES and a more accurate search of miscellaneous factors especially in elderly patients.

  4. Extranodal marginal zone non Hodgkin's lymphoma of the lung: A ten-year experience

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    Milošević Violeta

    2011-01-01

    Full Text Available Background/Aim. Bronchus-associated lymphoid tissue (BALT lymphoma is a rare subtype of low grade marginal zone B cell lymphoma representing 10% of all MALT lymphomas. The purpose of this study was to analyze the outcome of this group of patients comparing prognostic parameters and therapy modalities. Methods. A total of eight patients with BALT lymphoma had diagnosed between January 1998 - April 2008 at the Institute of Hematology, Clinical Center of Serbia, Belgrade, and they were included in this retrospective analysis. Results. Male/female ratio was 2/6, the median age was 64 years (range 37-67 years. Six patients had nonspecific respiratory symptoms and all of them had B symptoms. The patients were seronegative for HIV, HCV and HBsAg. Three patients had Sjogren's syndrome, rheumatoid arthritis and pulmonary tuberculosis, respectively. Seven patients were diagnosed by transbronchial biopsy and an open lung biopsy was done in one patient. Patohistological findings revealed lymphoma of marginal zone B cell lymphoma: CD20+/CD10-/CD5-/CyclinD1- /CD23-/IgM- with Ki-67+<20% of all cells. According to the Ferraro staging system, five patients had localized disease (CS I-IIE and three had stage IVE; bulky tumor mass had 3 patients. All patients had Eastern Cooperative Oncology Group (ECOG performance status (PS 0 or 1. Five patients received monochemotherapy with chlorambucil and 3 were treated with CHOP regimen (cyclophosphamide, doxorubicin, vincristine and prednisone. A complete response (CR was achieved in 5 patients and a partial response (PR in 3 of them, treated with chlorambucil monotherapy and CHOP regimen. All patients were alive during a median follow-up period of 49 months (range 6- 110 months. Three patients relapsed after monochemotherapy into the other extranodal localization. They were treated with CHOP regimen and remained in stable PR. Conclusion. BALT lymphoma tends to be localised disease at the time of diagnosis, responds well

  5. Minimal change disease: an unusual presentation of marginal zone MALT lymphoma.

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    Inayat, Faisal; Law, Jason K; Myers-Gurevitch, Patricia M; Seshan, Surya V; Perlman, Alan S

    2016-03-01

    Minimal change disease (MCD) in association with low-grade extra-nodal marginal zone B-cell lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT) (MALT lymphoma) is a rare clinicopathologic entity. We report a 68-year-old male who presented with nephrotic range proteinuria as the first manifestation of underlying MZL, confirmed with standard set of investigations. Being a steroid non-responder, he was treated with rituximab demonstrating a marked response with resolution of proteinuria. However, he relapsed after 3 months. Upon relapse, a combination of rituximab and bendamustine (R-Benda) was initiated achieving sustained resolution of proteinuria. No additional treatment was administered and the proteinuria has remained in remission for over a year.

  6. Glomerulonephritis associated with marginal zone B-cell lymphoma: clinical, pathological characteristics of renal injury and treatment (clinical cases

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    B. T. Dzhumabaeva

    2015-01-01

    Full Text Available Glomerulonephritis associated with marginal zone B-cell lymphoma at the onset of disease is rarely diagnosed. In this article we reported two patient of the extranodal marginal zone B-cell lymphoma with kidney damage. The first patient with the extranodal marginal zone B-cell lymphoma involved the stomach, lymph nodes, bone marrow and associated with mesangioproliferative glomerulonephritis and renal failure. The second patient with the splenic form of marginal zone B-cell lymphoma associated with fibrillary glomerulonephritis and hepatitis C and involve the lymph nodes, liver, bone marrow, and synthesis monoclonal immunoglobulin (IgMκ, cryoglobulin type II. Glomerulonephritis of the both cases were established on the renal biopsies by the morphological investigation, immunofluorescence, and electron microscopy.Both patients received therapy with bendamustine and rituximab, which has resulted in complete remission for lymphatic tumors and improve of kidney function. Overall and event-free survival in the first case corresponds to 21 and 16 months, the second 29 and 20, respectively.These cases illustrates that the kidney may be initially involved by extranodal marginal zone B-cell lymphoma, and the need for expanded investigation of the possible dissemination. Combination of bendamustine and rituximab were effective and safety treatment in these cases.

  7. Myeloid cell nuclear differentiation antigen is expressed in a subset of marginal zone lymphomas and is useful in the differential diagnosis with follicular lymphoma.

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    Metcalf, Ryan A; Monabati, Ahmad; Vyas, Monika; Roncador, Giovanna; Gualco, Gabriela; Bacchi, Carlos E; Younes, Sheren F; Natkunam, Yasodha; Freud, Aharon G

    2014-08-01

    The diagnosis of marginal zone lymphomas (MZL) is challenged by the lack of specific markers that distinguish them from other low-grade non-Hodgkin B-cell lymphomas. Myeloid cell nuclear differentiation antigen (MNDA) is a nuclear protein that labels myelomonocytic cells as well as B lymphocytes that localize to the marginal zone areas of splenic white pulp. We evaluated MNDA expression in a large series of B-cell lymphomas to assess the sensitivity and specificity of this antigen for the characterization of MZL. A total of 440 tissue sections containing extramedullary B-cell lymphomas and 216 bone marrow biopsies containing atypical or neoplastic lymphoid infiltrates were stained for MNDA by immunohistochemistry. Among the extramedullary lymphoma cases, approximately 67% of nodal MZL, 61% of extranodal MZL, and 24% of splenic MZL expressed MNDA. MNDA was also infrequently expressed in other B-cell neoplasms including mantle cell lymphoma (6%), chronic lymphocytic leukemia/small lymphocytic lymphoma (13%), follicular lymphoma (FL) (4%), lymphoplasmacytic lymphoma (25%), and diffuse large B-cell lymphoma (3%). In contrast, MNDA was only expressed in 2.3% of all bone marrow biopsies involved by lymphoid infiltrates, including 2 cases of FL and one case of MZL. Collectively, these data support the inclusion of MNDA in the diagnostic evaluation of extramedullary B-cell lymphomas, particularly those in which the differential diagnosis is between low-grade FL and MZL.

  8. [Clinical characteristics of splenic marginal zone lymphoma with abnormal complete blood count].

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    Yang, Shen-Miao; Jiang, Qian; Jiang, Bin; Chen, Ding-Bao; Wang, Jing; Jiang, Hao; Lu, Jin; Lu, Xi-Jing; Bao, Li; Shi, Hong-Xia; Liu, Yan-Rong; Huang, Xiao-Jun

    2013-02-01

    The aim of this study was to investigate the clinical and laboratorial characteristics of splenic marginal zone lymphoma (SMZL) with an abnormal complete blood count (CBC). Data of 19 newly diagnosed SMZL patients with abnormal CBC were analyzed retrospectively. Seven patients were diagnosed by using splenic histology, 12 patients who did not undergo splenectomy were diagnosed on the basis of typical clinical presentation and cytologic, immunophenotypic and histologic characteristics of peripheral blood and bone marrow, according to SBLG guidelines. The results showed that leukocytosis (≥ 10.0×10(9)/L) was seen in 5 cases (26.3%); leukocytopenia (complete response was achieved in 9 out of 11 (81.8%) patients. It is concluded that SMZL with abnormal CBC has a higher incidence of cytopenia, bone marrow involvement and autoimmune phenomena. Therapeutic strategies consisting of Rituximab show a better efficacy.

  9. Interference from lupus anticoagulant on von Willebrand factor measurement in splenic marginal zone lymphoma

    DEFF Research Database (Denmark)

    Vinholt, Pernille J; Nybo, Mads

    2015-01-01

    We present a case concerning a patient with splenic marginal zone lymphoma (SMZL) and isolated prolonged activated partial thromboplastin time (aPTT) caused by lupus anticoagulant. Von Willebrand factor (VWF) activity and antigen were immeasurable by latex particle immunoturbidimetric assays......, and several coagulation factor levels were decreased. However, VWF activity and antigen were normal when analyzed by other methods. Also, coagulation factor levels were normal if an aPTT reagent with low lupus anticoagulant sensitivity or a chromogenic method was applied. Altogether, the initial findings were...... because of lupus anticoagulant interference and in fact, the patient had normal VWF activity and coagulation status. Interference of lupus anticoagulant in clot-based assays is well known but has not previously been described in VWF assays. This is furthermore the first report in which lupus anticoagulant...

  10. Molecular pathogenesis and histologic and clinical features of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue type.

    NARCIS (Netherlands)

    Kuper-Hommel, M.J.; Krieken, J.H.J.M. van

    2012-01-01

    Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) type (EMZL) is considered an antigen driven lymphoid malignancy associated with protracted antigenic stimulation by microbial pathogens, auto-antigens or other unknown stimuli, which trigger a sustained lymphoid proliferat

  11. Paraneoplastic Syndrome in Splenic Marginal Zone Lymphoma: A Rare Phenomenon of Paraplegia as an Atypical Presenting Manifestation

    Directory of Open Access Journals (Sweden)

    Jessica Schering

    2016-01-01

    Full Text Available We describe a case presenting complaint of complete lower body paraparesis, which was discovered to have splenic marginal zone lymphoma (SMZL. While paraneoplastic syndromes are more common in tumors, such as small cell lung cancer, very few reports exist on this condition with SMZL. We describe such a rare entity with a clinical course spanning twenty-four months after diagnosis.

  12. Atypical Marginal Zone Hyperplasia Is a Mimic for Lymphoma in Pediatric Transplant Recipients: Report of Two Patients.

    Science.gov (United States)

    Caltharp, Shelley A; Qayed, Muna; Park, Sunita I

    2015-01-01

    Atypical marginal zone hyperplasia (AMZH) of mucosa-associated lymphoid tissue (MALT) closely resembles lymphoma in that it shows expansion of the marginal zones with prominent intraepithelial B lymphocytes, is immunoglobulin light-chain restricted, and may show aberrant CD43 expression. However, unlike lymphoma, it does not show rearrangement of the immunoglobulin heavy chain gene (immunoglobulin H [IgH]) by polymerase chain reaction (PCR), and it behaves in a benign fashion. We identified AMZH in 2 pediatric solid organ transplant recipients who presented with adenotonsillar hypertrophy. To date, the patients have experienced a self-limited course in the absence of treatment or reduction of immunosuppression. Atypical marginal zone hyperplasia is a pitfall for posttransplant lymphoproliferative disorder and MALT lymphoma in the pediatric solid organ transplant population. In transplant patients with a lambda-restricted B-cell clone and marginal zone hyperplasia in native MALT sites, PCR for IgH and IgK gene rearrangement is essential to prevent misdiagnosis.

  13. Employment of Oligodeoxynucleotide plus Interleukin-2 Improves Cytogenetic Analysis in Splenic Marginal Zone Lymphoma

    Directory of Open Access Journals (Sweden)

    Antonella Bardi

    2011-01-01

    Full Text Available To compare the efficiency of novel mitogenic agents and traditional mitosis inductors, 18 patients with splenic marginal zone lymphoma (SMZL were studied. Three cultures using oligodeoxynucleotide (ODN plus interleukin-2 (IL-2, or TPA, or LPS were setup in each patient. Seventeen/18 cases with ODN+IL2 had moderate/good proliferation (94,4% as compared with 10/18 cases with TPA and LPS (55% (P=.015; 14/18 (77,7% cases with ODN+IL2 had sufficient good quality of banding as compared with 8/18 cases (44,4% with TPA and LPS. The karyotype could be defined from ODN+IL2-stimulated cultures in all 18 patients, 14 of whom (77,7% had a cytogenetic aberration, whereas clonal aberrations could be documented in 9 and in 3 cases by stimulation with LPS and TPA, respectively. Recurrent chromosome aberrations in our series were represented by aberrations of chromosome 14q in 5 patients, by trisomy 12 and 7q deletion in 4 cases each, and by abnormalities involving 11q and 13q in two cases each. These findings show that stimulation with ODN+IL2 offers more mitotic figures of better quality and results in an increased rate of clonal aberrations in SMZL, making this method ideal for prospective studies aiming at the definition of the prognostic impact of cytogenetic aberrations in this disorder.

  14. Splenic Marginal Zone Lymphoma in the Setting of Noncirrhotic Portal Hypertension.

    Science.gov (United States)

    Ratnayake, Saman; Ammar, Ali; Rezvani, Rodd; Petersen, Greti

    2015-01-01

    We present a case of a 65-year-old Hispanic man with a history of disseminated cutaneous coccidioidomycosis who presented to the emergency room for progressively worsening abdominal pain associated with shortness of breath. The patient was found to have pleural effusion and moderate ascites on physical examination. Abdominal ultrasound and computed tomography scan were consistent with moderate ascites and portal hypertension but negative for both liver cirrhosis and for venous or arterial thrombosis. Cytology of ascitic fluid was suggestive of portal hypertension and was negative for infection. Subsequent, thoracentesis was suggestive of exudative effusion and also negative for infection. Liver biopsy confirmed the absence of cirrhosis. Complete blood count indicated pancytopenia, whereas bone marrow biopsy and flow cytometry were suggestive of marginal zone lymphoma (MZL). Clinically, the patient's shortness of breath was resolved by thoracentesis and paracentesis; however, his abdominal pain persisted. A diagnosis of idiopathic noncirrhotic portal hypertension in the setting of splenic MZL was made. The patient was transferred to a higher level of care for splenectomy; however, he missed multiple appointments. Since discharge, the patient has been seen in the outpatient setting and states that he is controlling his disease with diet and exercise; however, he continues to complain of intermittent shortness of breath with exertion.

  15. Employment of Oligodeoxynucleotide plus Interleukin-2 Improves Cytogenetic Analysis in Splenic Marginal Zone Lymphoma

    Science.gov (United States)

    Bardi, Antonella; Cavazzini, Francesco; Rigolin, Gian Matteo; Tammiso, Elisa; Volta, Eleonora; Pezzolo, Elisa; Formigaro, Luca; Sofritti, Olga; Daghia, Giulia; Ambrosio, Cristina; Rizzotto, Lara; Abass, Awad E.; D'Auria, Fiorella; Musto, Pellegrino; Cuneo, Antonio

    2011-01-01

    To compare the efficiency of novel mitogenic agents and traditional mitosis inductors, 18 patients with splenic marginal zone lymphoma (SMZL) were studied. Three cultures using oligodeoxynucleotide (ODN) plus interleukin-2 (IL-2), or TPA, or LPS were setup in each patient. Seventeen/18 cases with ODN + IL2 had moderate/good proliferation (94, 4%) as compared with 10/18 cases with TPA and LPS (55%) (P = .015); 14/18 (77, 7%) cases with ODN + IL2 had sufficient good quality of banding as compared with 8/18 cases (44, 4%) with TPA and LPS. The karyotype could be defined from ODN + IL2-stimulated cultures in all 18 patients, 14 of whom (77, 7%) had a cytogenetic aberration, whereas clonal aberrations could be documented in 9 and in 3 cases by stimulation with LPS and TPA, respectively. Recurrent chromosome aberrations in our series were represented by aberrations of chromosome 14q in 5 patients, by trisomy 12 and 7q deletion in 4 cases each, and by abnormalities involving 11q and 13q in two cases each. These findings show that stimulation with ODN + IL2 offers more mitotic figures of better quality and results in an increased rate of clonal aberrations in SMZL, making this method ideal for prospective studies aiming at the definition of the prognostic impact of cytogenetic aberrations in this disorder. PMID:21629757

  16. Splenic Marginal Zone Lymphoma in the Setting of Noncirrhotic Portal Hypertension

    Directory of Open Access Journals (Sweden)

    Saman Ratnayake MD

    2015-09-01

    Full Text Available We present a case of a 65-year-old Hispanic man with a history of disseminated cutaneous coccidioidomycosis who presented to the emergency room for progressively worsening abdominal pain associated with shortness of breath. The patient was found to have pleural effusion and moderate ascites on physical examination. Abdominal ultrasound and computed tomography scan were consistent with moderate ascites and portal hypertension but negative for both liver cirrhosis and for venous or arterial thrombosis. Cytology of ascitic fluid was suggestive of portal hypertension and was negative for infection. Subsequent, thoracentesis was suggestive of exudative effusion and also negative for infection. Liver biopsy confirmed the absence of cirrhosis. Complete blood count indicated pancytopenia, whereas bone marrow biopsy and flow cytometry were suggestive of marginal zone lymphoma (MZL. Clinically, the patient’s shortness of breath was resolved by thoracentesis and paracentesis; however, his abdominal pain persisted. A diagnosis of idiopathic noncirrhotic portal hypertension in the setting of splenic MZL was made. The patient was transferred to a higher level of care for splenectomy; however, he missed multiple appointments. Since discharge, the patient has been seen in the outpatient setting and states that he is controlling his disease with diet and exercise; however, he continues to complain of intermittent shortness of breath with exertion.

  17. Treatment of splenic marginal zone lymphoma of the CNS with high-dose therapy and allogeneic stem cell transplantation

    Directory of Open Access Journals (Sweden)

    Busemann Christoph

    2012-10-01

    Full Text Available Abstract Therapy of indolent lymphomas with involvement of the central nervous system (CNS has not been standardized so far. A 42-year old male patient presented with neurological signs because of leukemic splenic marginal zone lymphoma (SMZL manifested in bone marrow, lymph nodes and CNS. Due to the aggressiveness of the disease and the young age of the patient, an intensive immunochemotherapy followed by high-dose therapy with busulfan, thiotepa and fludarabine and subsequent unrelated allogeneic stem cell transplantation (alloSCT was performed. The haemopoietic stem cells engrafted in time and the patient is doing well (ECOG 0 without evidence for active lymphoma three years after transplantation. Highly sensitive tests by specific quantitative real-time polymerase chain reaction for presence of lymphoma cells in blood and bone marrow indicated also a molecular remission. The reported case shows the feasibility of high-dose therapy and allogeneic stem cell transplantation in high-risk patients with CNS-involvement of indolent non-Hodgkin’s lymphoma. In addition, the case supports the hypothesis that the graft-versus lymphoma effect after alloSCT is also active within the CNS.

  18. Splenectomy with chemotherapy vs surgery alone as initial treatment for splenic marginal zone lymphoma

    Institute of Scientific and Technical Information of China (English)

    Rajko Milosevic; Milena Todorovic; Bela Balint; Miodrag Jevtic; Miodrag Krstic; Elizabeta Ristanovic; Nebojsa Antonijevic; Mirjana Pavlovic; Maja Perunicic; Milan Petrovic; Biljana Mihaljevic

    2009-01-01

    AIM:To evaluate the clinical characteristics of splenic marginal-zone lymphoma (SMZL) following antigen expression and the influence of therapeutic approaches on clinical outcome and overall survival (OS).METHODS:A total of 30 patients with typical histological and immunohistochemical SMZL patterns were examined.Splenectomy plus chemotherapy was applied in 20 patients,while splenectomy as a single treatment-option was performed in 10 patients.Prognostic factor and overall survival rate were analyzed.RESULTS:Complete remission (CR) was achieved in 20 (66.7%),partial remission (PR) in seven (23.3%),and lethal outcome due to disease progression occurred in three (10.0%) patients.Median survival of patients with a splenectomy was 93.0 mo and for patients with splenectomy plus chemotherapy it was 107.5 mo (Log rank=0.056,P>0.05).Time from onset of first symptoms to the beginning of the treatment (mean 9.4 mo) was influenced by spleen dimensions,as measured by computerized tomography and ultra-sound (t=2.558,P=0.018).Strong positivity (+++) of CD20 antigen expression in splenic tissue had a positive influence on OS (Log rank = 5.244,P 0.05) effects on the OS.The expression of other antigens (immunohistochemistry) also had no effect on survival-rate,as measured by a χ2 test (P > 0.05).CONCLUSION:Initial splenectomy combined with chemotherapy has been shown to be beneficial due to its advanced remission rate/duration;however,a larger controlled clinical study is required to confirm our findings.

  19. Autoimmune hemolytic anemia as a risk factor of poor outcome in patients with splenic marginal zone lymphoma.

    Science.gov (United States)

    Fodor, Aniko; Molnar, Miklos Zsolt; Krenacs, Laszlo; Bagdi, Eniko; Csomor, Judit; Matolcsy, Andras; Demeter, Judit

    2009-12-01

    Splenic marginal zone lymphoma is a rare disease, accounting for 1% of all lymphomas. We reviewed our single center experience of 13 patients with splenic marginal zone lymphoma (SMZL). Based on the prognostic model developed by Intergruppo Italiano Linfomi, 31% (4/13) of our patients had good, 38% (5/13) had intermediate and 31% (4/13) had a poor prognosis. The presence of two out of three prognostic factors (anemia, elevated LDH, low serum albumin) assignes the patient into the high risk category. In patients with anemia and an elevated LDH due to hemolysis, the outcome seems to be especially poor. Three out of 13 (23%) cases were complicated by autoimmune hemolytic anemia. All patients with autoimmune hemolytic anaemia (AIHA) died 7-28 months after the diagnosis. The mean follow-up time of those nine patients who are still alive is longer than 5 years (36-100 months). Patients with AIHA had significantly (p < 0.001) worse survival than those without AIHA. The main finding of our study is that the presence of AIHA is an adverse prognostic factor in SMZL.

  20. Primary endobronchial marginal zone B-cell lymphoma of bronchus-associated lymphoid tissue: CT findings 7 patients

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Ra Gyoung; Kim, Mi Young; Song, Jae Woo; Chae, Eun Jin; Choi, Chang Min; Jang, Se Jin [University of Ulsan College of Medicine, Seoul (Korea, Republic of)

    2013-04-15

    To investigate CT and 1{sup 8F}-fluorodeoxyglucose (1{sup 8F}-FDG) positron-emission tomography/CT findings of primary endobronchial marginal zone B-cell lymphoma of the bronchus-associated lymphoid tissue (BALT). From June 2006 through April 2012, seven patients (six female, one male; age range, 21-61 years; mean age, 49 years) were examined who were pathologically diagnosed with the primary endobronchial marginal zone B-cell lymphoma of BALT. We evaluated the locations and characteristics of the lesions on CT and 1{sup 8F}-FDG-PET/CT scans. The lesions were classified into the following three patterns: 1) solitary intraluminal nodule; 2) several tiny nodular protrusions; and 3) diffuse wall thickening. A solitary intraluminal nodule was observed in four patients (57.1%), several tiny nodular protrusion in two patients (28.6%), and diffuse wall thickening in one patient (14.3%). The lesions were categorized into 3 major locations: confined to the trachea (n 3), confined to the lobar bronchus (n = 2), and diffuse involvement of the trachea and both main bronchi (n = 2). All lesions demonstrated homogeneous iso-attenuation as compared with muscle on pre- and post-enhancement scans. Secondary findings in the lungs (n = 3; 42.9%) included postobstructive lobar atelectasis (n = 1), air trapping (n = 1), and pneumonia (n = 1). On 1{sup 8F}-FDG-PET/CT (n = 5), 4 lesions showed homogeneous uptake with maximum standardized uptake values (mSUV), ranging 2.3-5.7 (mean mSUV: 3.3). One lesion showed little FDG uptake. Primary endobronchial marginal zone B-cell lymphoma of the BALT manifests as three distinct patterns on CT, with the solitary intraluminal nodule presenting as the main pattern. Most lesions demonstrate homogeneous but weak FDG uptake on 1{sup 8F}-FDG-PET/CT.

  1. An Unusual Case of Marginal Zone B-Cell Lymphoma Arising in the Breast - Its Diagnosis and the Role of Radiotherapy in its Management.

    LENUS (Irish Health Repository)

    Rock, Kathy

    2011-10-01

    BACKGROUND: Primary lymphoma of the breast accounts for 0.04-0.5% of all breast malignancies and approximately 1% of all extranodal lymphomas. For stage IE node-negative disease, involved field radiotherapy is recommended except for very young women in whom the risk of breast cancer is a concern. The rate of complete response for limited stage extranodal marginal B-cell lymphoma is in excess of 90%. CASE REPORT: We report the case of a 62-year-old lady who presented with a unilateral painless palpable right breast lump. She subsequently underwent a trucut biopsy of the lesion. The histology revealed a low-grade B-cell non-Hodgkin\\'s lymphoma (NHL). Immunohistochemistry showed that more than 95% of the cells were B cells which were CD 20+\\/CD 45+ and BC L6+. This confirmed the diagnosis of marginal zone lymphoma. Staging work-up was negative for distant metastases. Serum alkaline phosphatase and lactate dehydrogenase were normal. The patient had no \\'B\\' symptoms. Her final diagnosis was clinical stage IAE NHL, and she was referred for curative radiotherapy. CONCLUSION: Radiation treatment is a safe and extremely effective modality of treatment for early stage I marginal zone B-cell lymphomas of the breast.

  2. An Unusual Case of Marginal Zone B-Cell Lymphoma Arising in the Breast - Its Diagnosis and the Role of Radiotherapy in its Management.

    Science.gov (United States)

    Rock, Kathy; Rangaswamy, Guhan; O'Sullivan, Siobhra; Coffey, Jerome

    2011-10-01

    BACKGROUND: Primary lymphoma of the breast accounts for 0.04-0.5% of all breast malignancies and approximately 1% of all extranodal lymphomas. For stage IE node-negative disease, involved field radiotherapy is recommended except for very young women in whom the risk of breast cancer is a concern. The rate of complete response for limited stage extranodal marginal B-cell lymphoma is in excess of 90%. CASE REPORT: We report the case of a 62-year-old lady who presented with a unilateral painless palpable right breast lump. She subsequently underwent a trucut biopsy of the lesion. The histology revealed a low-grade B-cell non-Hodgkin's lymphoma (NHL). Immunohistochemistry showed that more than 95% of the cells were B cells which were CD 20+/CD 45+ and BC L6+. This confirmed the diagnosis of marginal zone lymphoma. Staging work-up was negative for distant metastases. Serum alkaline phosphatase and lactate dehydrogenase were normal. The patient had no 'B' symptoms. Her final diagnosis was clinical stage IAE NHL, and she was referred for curative radiotherapy. CONCLUSION: Radiation treatment is a safe and extremely effective modality of treatment for early stage I marginal zone B-cell lymphomas of the breast.

  3. Indolent B-Cell Lymphoid Malignancy in the Spleen of a Man Who Handled Benzene: Splenic Marginal Zone Lymphoma.

    Science.gov (United States)

    Lee, Jihye; Kang, Young Joong; Ahn, Jungho; Song, Seng-Ho

    2017-09-01

    We present the case of a 45-year-old man with a history of benzene exposure who developed splenic marginal zone lymphoma. For 6 years, he had worked in an enclosed space cleaning instruments with benzene. He was diagnosed with splenic marginal zone lymphoma 19 years after retirement. During his time of working in the laboratory in the 1980s, working environments were not monitored for hazardous materials. We indirectly estimated the cumulative level of past benzene exposure using job-exposure matrices and technical assumptions. Care must be taken in investigating the relevance of occupational benzene exposure in the occurrence of indolent B-cell lymphoma. Because of the long latency period and because occupational measurement data do not exist for the period during the patient's exposure, the epidemiological impact of benzene exposure may be underestimated.

  4. Gastric marginal zone lymphoma of mucosa-associated lymphoid tissue and signet ring cell carcinoma, synchronous collision tumour of the stomach: a case report.

    Science.gov (United States)

    George, Smiley Annie; Junaid, T A

    2014-01-01

    To report a rare case of synchronous marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) signet ring cell carcinoma occurring as a collision tumour in the stomach. A 53-year-old man was diagnosed initially with signet ring cell carcinoma of the stomach. The microscopy of the subsequent total gastrectomy revealed a collision tumour of MALT lymphoma and signet ring cell carcinoma associated with Helicobacter pylori gastritis. This case highlighted the importance of a careful evaluation of the accompanying lymphoid population in the biopsy samples of gastric adenocarcinoma and underlined the need for multiple endoscopic biopsies to detect these rare synchronous tumours. © 2013 S. Karger AG, Basel.

  5. Clinicopathological Analysis of Pulmonary Marginal Zone B-cell Lymphoma of 
Mucosa-associated Lymphoid Tissue

    Directory of Open Access Journals (Sweden)

    Jing ZENG

    2011-05-01

    Full Text Available Background and objective As a rare disease, pulmonary marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (PMZL-MALT, is often misdiagnosed. The aim of this study is to summarize the clinical and pathological features of this disease and improve the awareness of doctors. Methods Seven cases (female 5, male 2 diagnosed of PMZL-MALT in West China Hospital between November 2008 and November 2010, were analyzed retrospectively, including their symptoms, radiological findings, pathological examinations, treatment and prognosis. Results The median age of the patients were 62 years old (range 34-79 years. Six patients suffered from cough and sputum. Pulmonary consolidation was the most frequent manifestation, leading a misdiagnosis of pneumonia with CT examinations. Pathological diagnosis was obtained via fiberoptic bronchoscopy in six patients and percutaneous pulmonary biopsy for the rest one. In the seven cases, immunohistochemical results showed CD20(+, CD79a(+, while CD3 epsilon(-, CD5(-, CyclinD1(-, CD10(-, Bcl-2(- and CD30(-. Additionally, the expression of Ki-67 was below 10%. Further PCR analysis showed evidence of immunoglobulin heavy chain gene rearrangement in tissues from six subjects. Based on the disease location and patients’ wishes, compared with two cases just receiving symptomatic treatments, the other five ones took in chemotherapies. Conclusion Since there were no specific clinical features for patients of PMZL-MALT, histopathological examination was the only effective means to confirm the diagnosis.

  6. Marginal zone B-cell lymphoma with multiple extranodal locations in a patient with Sjögren’s syndrome – a diagnostic problem

    Directory of Open Access Journals (Sweden)

    Marta Domżalska

    2014-09-01

    Full Text Available Sjögren’s syndrome is a chronic autoimmune disease characterized by the presence of lymphocytic infiltrates in exocrine glands, mainly salivary and lacrimal glands, which result in xerophthalmia and xerostomia. About half of the patients develop systemic complications, including lymphoproliferative disorders. We report a case of a 27-year-old woman with a diagnosis of Sjögren’s syndrome and a suspicion of respiratory system involvement in the course of granulomatosis with polyangiitis. Histopathological examination of a skin lesion suggested marginal zone B-cell lymphoma. After pathological and immunohistochemical evaluation of all available previous biopsy samples and the medical documentation the diagnosis of extranodal marginal zone B-cell lymphoma stage IV according to the Ann Arbor classification was rendered. The patient was referred to the Department of Haematology and was treated with R-CVP (cyclophosphamide, vincristine, prednisone, rituximab.

  7. Results of a randomized trial of chlorambucil versus fludarabine for patients with untreated Waldenström macroglobulinemia, marginal zone lymphoma, or lymphoplasmacytic lymphoma.

    Science.gov (United States)

    Leblond, Véronique; Johnson, Steve; Chevret, Sylvie; Copplestone, Adrian; Rule, Simon; Tournilhac, Olivier; Seymour, John Francis; Patmore, Russell D; Wright, David; Morel, Pierre; Dilhuydy, Marie-Sarah; Willoughby, Sara; Dartigeas, Caroline; Malphettes, Marion; Royer, Bruno; Ewings, Maeve; Pratt, Guy; Lejeune, Julie; Nguyen-Khac, Florence; Choquet, Sylvain; Owen, Roger G

    2013-01-20

    Treatment options for patients with Waldenström macroglobulinemia (WM) and closely related disorders include alkylating agents, purine analogs, and monoclonal antibodies. No large randomized studies have yet been reported comparing any of these approaches. The randomized WM1 study (Trial Comparing Chlorambucil to Fludarabine in Patients With Advanced Waldenström Macroglobulinemia) was undertaken in 101 centers in five countries enrolling 414 eligible patients (339 with WM, 37 with non-mucosa-associated lymphoid tissue marginal zone lymphoma, and 38 with lymphoplasmacytic lymphoma) who were randomly assigned to receive chlorambucil or fludarabine. The primary end point was the overall response rate (ORR). On the basis of intent-to-treat analysis, the ORR was 47.8% (95% CI, 40.9% to 54.8%) in the fludarabine arm versus 38.6% (95% CI, 32.0% to 45.7%) in the chlorambucil arm (P = .07). With a median follow-up of 36 months (interquartile range, 18 to 58 months), median progression-free survival (PFS), and duration of response (DR) were significantly improved in the fludarabine arm compared with the chlorambucil arm: PFS, 36.3 versus 27.1 months (P = .012) and DR, 38.3 versus 19.9 months (P chlorambucil arm (95% CI, 61.6 to 79.8 months; P = .014). Grade 3 to 4 neutropenia was significantly higher among patients treated with fludarabine (36%) compared with patients treated with chlorambucil (17.8%; P chlorambucil arm with 6-year cumulative incidence rate of 20.6% versus 3.7% in the fludarabine arm (P = .001). In the complete intent-to-treat study population, fludarabine significantly improved PFS compared with chlorambucil, and in patients with WM, it improved OS.

  8. Epstein-barr virus-associated extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT Lymphoma) arising in the parotid gland of a child with ataxia telangiectasia.

    Science.gov (United States)

    Bennett, Jennifer A; Bayerl, Michael G

    2015-03-01

    Hematologic malignancies, in particular T-cell lymphomas/leukemias, are prevalent in patients with ataxia telangiectasia (AT), with most reported cases being clinically aggressive and high grade. Epstein-Barr virus (EBV) is often associated with lymphoid proliferations/neoplasms arising in immunodeficient patients. Reports of low-grade B-cell neoplasms in the ataxia telangiectasia population are extremely rare. Here, we describe a case of EBV-associated extranodal marginal zone lymphoma (mucosa-associated lymphoid tissue lymphoma) of the parotid gland in a 16-year-old boy with AT. In addition, we review the literature of hematologic malignancies in the AT population as well as the occurrence of EBV in mucosa-associated lymphoid tissue lymphoma.

  9. Primary Thymic Extranodal Marginal-Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Exhibits Distinctive Clinicopathological and Molecular Features

    Science.gov (United States)

    Inagaki, Hiroshi; Chan, John K. C.; Ng, Josephine W. M.; Okabe, Mitsukuni; Yoshino, Tadashi; Okamoto, Masataka; Ogawa, Hiroshi; Matsushita, Hiroshi; Yokose, Tomoyuki; Matsuno, Yoshihiro; Nakamura, Naoya; Nagasaka, Tetsuro; Ueda, Ryuzo; Eimoto, Tadaaki; Nakamura, Shigeo

    2002-01-01

    Extranodal marginal-zone B-cell lymphoma (MZBL) of mucosa-associated lymphoid tissue (MALT) arising in the thymus is rare, with the largest series in the literature including only three cases. In the present study, we investigated 15 cases of thymic MALT lymphoma to systematically characterize its clinical, histopathological, and molecular features. There was a marked female predilection (male:female = 1:4), with a mean age of 55 years at diagnosis. There was a strong association with autoimmune disease, especially Sjögren’s syndrome. Histologically, the thymic lymphoma showed the characteristic morphological features of extranodal MZBL of MALT type. Cysts were common. Prominent lymphoepithelial lesions were formed by centrocyte-like cells infiltrating and expanding the Hassall’s corpuscles and epithelium lining the cysts. Plasmacytic differentiation was apparent in all cases. Notably, 13 of 15 cases expressed immunoglobulin (Ig) A phenotype; IgA expression in thymic MALT lymphoma was in striking contrast with the IgM phenotype observed in most of the Sjögren’s syndrome-associated MZBLs and MALT lymphomas at other sites. Epstein-Barr virus was absent, and API2-MALT1 gene fusion, a recently reported MALT lymphoma-specific gene abnormality, was not detected in any case. Although one patient died of disease 85 months after the diagnosis, other patients were alive with overall 3-year and 5-year survival rates being 89% and 83%, respectively. Among the 22 patients reported previously and in the present series, at least 17 patients (77%) were Asians. These data indicate that thymic MALT lymphoma may represent a distinct subgroup of MALT lymphoma characterized by apparent predilection for Asians, a strong association with autoimmune disease, frequent presence of cysts, consistent plasma cell differentiation, tumor cells expressing IgA phenotype, and consistent lack of API2-MALT1 gene fusion. PMID:11943727

  10. Radiation Therapy Administration and Survival in Stage I/II Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue

    Energy Technology Data Exchange (ETDEWEB)

    Olszewski, Adam J., E-mail: adam_olszewski@brown.edu; Desai, Amrita

    2014-03-01

    Purpose: To determine the factors associated with the use of radiation therapy and associated survival outcomes in early-stage marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT). Methods and Materials: We extracted data on adult patients with stage I/II MALT lymphoma diagnoses between 1998 and 2010 recorded in the Surveillance, Epidemiology, and End Results (SEER) database. We studied factors associated with radiation therapy administration in a logistic regression model and described the cumulative incidence of lymphoma-related death (LRD) according to receipt of the treatment. The association of radiation therapy with survival was explored in multivariate models with adjustment for immortal time bias. Results: Of the 7774 identified patients, 36% received radiation therapy as part of the initial course of treatment. Older patients; black or Hispanic men; white, Hispanic, and black women; and socioeconomically disadvantaged and underinsured patients had a significantly lower chance of receiving radiation therapy. Radiation therapy administration was associated with a lower chance of LRD in most sites. In cutaneous, ocular, and salivary MALT lymphomas, the 5-year estimate of LRD after radiation therapy was 0%. The association of radiation therapy with overall survival in different lymphoma sites was heterogeneous, and statistically significant in cutaneous (hazard ratio 0.45, P=.009) and ocular (hazard ratio 0.47, P<.0001) locations after multivariate adjustment. Conclusions: Demographic factors are associated with the use of radiation therapy in MALT lymphoma. Clinicians should be sensitive to those disparities because the administration of radiation therapy may be associated with improved survival, particularly in cutaneous and ocular lymphomas.

  11. A Case of Contiguous Primary Hepatic Marginal Zone B-Cell Lymphoma and Hemangioma Ultimately Diagnosed Using Contrast-Enhanced Ultrasonography

    Directory of Open Access Journals (Sweden)

    Kazue Shiozawa

    2015-02-01

    Full Text Available Primary hepatic marginal zone B-cell malignant lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma is extremely rare. We present a case in which a lesion was diagnosed as 2 contiguous tumors (MALT lymphoma and hemangioma using contrast-enhanced ultrasonography (US with sonazoid. There has been no previous case of contiguous hepatic MALT lymphoma and hemangioma. The present case was a female with no medical history. We detected a snowman-like appearance, which was a tumor of 15 mm in diameter with hypo- and hyper-echogenicities in the lateral and medial parts, respectively, in the Couinaud's segment (S6 of the liver on US. The tumor appeared as a single lesion with a low-density area in the unenhanced phase and prolonged enhancement in the equilibrium phases on dynamic CT. On MRI, the whole lesion showed a low-intensity signal on T1-weighted imaging, but isointensity in the lateral part and high intensity in the medial part were seen on T2-weighted imaging. On contrast-enhanced US, the lateral hypoechoic region was homogenously hyperenhanced in the early vascular phase, and the contrast medium was washed out after about 30 s; in contrast, the medial hyperechoic region was gradually stained from the margin toward the central region. The tumor showed a defect in both hypo- and hyperechoic regions in the postvascular phase. Hemangioma was suspected for the medial part based on the typical image findings, but the lateral part was not given a diagnosis. Thus, surgical resection was performed. The medial part was a hemangioma, and the lateral part was a MALT lymphoma by histopathological findings.

  12. Primary cutaneous B-cell lymphoma other than marginal zone: clinicopathologic analysis of 161 cases: Comparison with current classification and definition of prognostic markers.

    Science.gov (United States)

    Lucioni, Marco; Berti, Emilio; Arcaini, Luca; Croci, Giorgio A; Maffi, Aldo; Klersy, Catherine; Goteri, Gaia; Tomasini, Carlo; Quaglino, Pietro; Riboni, Roberta; Arra, Mariarosa; Dallera, Elena; Grandi, Vieri; Alaibac, Mauro; Ramponi, Antonio; Rattotti, Sara; Cabras, Maria Giuseppina; Franceschetti, Silvia; Fraternali-Orcioni, Giulio; Zerbinati, Nicola; Onida, Francesco; Ascani, Stefano; Fierro, Maria Teresa; Rupoli, Serena; Gambacorta, Marcello; Zinzani, Pier Luigi; Pimpinelli, Nicola; Santucci, Marco; Paulli, Marco

    2016-10-01

    Categorization of primary cutaneous B-cell lymphomas (PCBCL) other than marginal zone (MZL) represents a diagnostic challenge with relevant prognostic implications. The 2008 WHO lymphoma classification recognizes only primary cutaneous follicular center cell lymphoma (PCFCCL) and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), whereas the previous 2005 WHO/EORTC classification also included an intermediate form, namely PCDLBCL, other. We conducted a retrospective, multicentric, consensus-based revision of the clinicopathologic characteristics of 161 cases of PCBCL other than MZL. Upon the histologic features that are listed in the WHO classification, 96 cases were classified as PCFCCL and 25 as PCDLBCL-LT; 40 further cases did not fit in the former subgroups in terms of cytology and/or architecture, thus were classified as PCDLBCL, not otherwise specified (PCDLBCL-NOS). We assigned all the cases a histogenetic profile, based on the immunohistochemical detection of CD10, BCL6, and MUM1, and a "double hit score" upon positivity for BCL2 and MYC. PCDLBCL-NOS had a clinical presentation more similar to PCFCCL, whereas the histology was more consistent with the picture of a diffuse large B-cell lymphoma, as predominantly composed of centroblasts but with intermixed a reactive infiltrate of small lymphocytes. Its behavior was intermediate between the other two forms, particularly when considering only cases with a "non-germinal B-cell" profile, whereas "germinal center" cases resembled PCFCCL. Our data confirmed the aggressive behavior of PCDLBC-LT, which often coexpressed MYC and BCL2. The impact of single factors on 5-year survival was documented, particularly histogenetic profile in PCDLBCL and BCL2 translocation in PCFCCL. Our study confirms that a further group-PCDLBCL-NOS-exists, which can be recognized through a careful combination of histopathologic criteria coupled with adequate clinical information.

  13. Bone marrow histopathology in the diagnostic evaluation of splenic marginal-zone and splenic diffuse red pulp small B-cell lymphoma: a reliable substitute for spleen histopathology?

    Science.gov (United States)

    Ponzoni, Maurilio; Kanellis, George; Pouliou, Evi; Baliakas, Panagiotis; Scarfò, Lydia; Ferreri, Andrés J M; Doglioni, Claudio; Bikos, Vasilis; Dagklis, Antonis; Anagnostopoulos, Achilles; Ghia, Paolo; Stamatopoulos, Kostas; Papadaki, Theodora

    2012-11-01

    Primary splenic small B-cell lymphomas mostly comprise the distinct entity of splenic marginal-zone lymphoma (SMZL) and the provisional category of splenic lymphoma/leukemia unclassifiable, mainly represented by the hairy cell leukemia variant and splenic diffuse red pulp small B-cell lymphoma (SDRL). Until recently, histopathologic examination of splenectomy specimens was considered mandatory for the diagnosis of SMZL. However, nowadays, mainly because of advances in chemoimmunotherapy, splenectomy is performed much less frequently. We evaluated the diagnostic efficacy of bone marrow biopsy (BMB) histopathology in the diagnostic approach toward SMZL and SDRL and tested whether it may serve as a substitute for spleen histopathology in the differential diagnosis between these 2 entities. To this end, we conducted a paired assessment of BMB and spleen diagnostic samples from 46 cases with a diagnosis of SMZL (n=32) or SDRL (n=14) based on spleen histopathology. We demonstrate that detailed immunohistopathologic BMB evaluation offers adequate evidence for the confirmation of these entities and their differential diagnosis from other small B-cell lymphoma histotypes. Notably, the immunophenotypical profile of SMZL and SDRL was identical in both BMB and spleen specimens for 21 evaluated markers. Paired assessment of BMB and spleen specimens did not identify discriminating patterns of BMB infiltration, cytology, and/or immunohistology between SMZL and SDRL. Accordingly, bone marrow histopathology contributes significantly in confirming the diagnosis of SMZL and SDRL. However, presently it is not possible to distinguish SMZL from SDRL on the basis of BMB evaluation alone; hence, histopathologic examination of the spleen remains the "gold standard" approach.

  14. A minute focus of extranodal marginal zone B-cell lymphoma arising in Hashimoto thyroiditis diagnosed with PCR after laser capture microdissection: a case report

    Directory of Open Access Journals (Sweden)

    D'Antonio Antonio

    2009-09-01

    Full Text Available Abstract Background Primary thyroid gland lymphomas are uncommon tumours that occur in the setting of lymphocytic thyroiditis or Hashimoto's disease in almost all cases. In this condition a distinction between an inflammatory lymphoid infiltrate and a low grade lymphoma may be extremely difficult and precise criteria are necessary for a correct diagnosis. Patient and methods We report a case of a minute focus of primary extranodal marginal zone B-cell lymphoma (EMZBCL, incidentally discovered in a 63-year-old man with Hashimoto thyroiditis (HT and diagnosed by means of polymerase chain reaction (PCR after laser capture microdissection. The histological examination of surgical specimen confirmed the diagnosis of HT and showed a minute focus of dense lymphoid infiltrate (less than 4 mm in diameter, composed by centrocyte-like cells forming MALT balls. Immunoistochemistry was not useful. A microscopic focus of EMZBCL was suspected on the basis of morphological features. PCR assays revealed the rearrangement of the heavy chain of immunoglobulins only in the microdissected suspicious area, confirming the diagnosis of EMZBCL. Conclusion Our finding suggests that in cases of autoimmune thyroiditis a careful examination of the thyroid specimen is warranted, in order to disclose areas or small foci of lymphomatous transformation. Furthermore, in difficult cases with doubtful immunohistological findings, ancillary techniques, such as molecular studies, are necessary for a conclusive diagnosis.

  15. Agatolimod Sodium, Rituximab, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Recurrent or Refractory Non-Hodgkin Lymphoma

    Science.gov (United States)

    2016-01-04

    Adult Non-Hodgkin Lymphoma; Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Nodal Marginal Zone Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia

  16. 506U78 in Treating Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or T-cell Lymphoma

    Science.gov (United States)

    2013-01-22

    Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

  17. Long-Term Outcomes and Patterns of Relapse of Early-Stage Extranodal Marginal Zone Lymphoma Treated With Radiation Therapy With Curative Intent

    Energy Technology Data Exchange (ETDEWEB)

    Teckie, Sewit; Qi, Shunan; Lovie, Shona [Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York (United States); Navarrett, Scott [Weill Cornell Medical College, New York, New York (United States); Hsu, Meier [Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York (United States); Noy, Ariela; Portlock, Carol [Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York (United States); Yahalom, Joachim, E-mail: yahalomj@mskcc.org [Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York (United States)

    2015-05-01

    Purpose: To report the long-term outcome and patterns of relapse of a large cohort of marginal zone lymphoma (MZL) patients treated with curative-intent radiation therapy (RT) alone. Patients and Methods: We reviewed the charts of 490 consecutive patients with stage IE or IIE MZL referred between 1992 and 2012 to our institution. Of those, 244 patients (50%) were treated with RT alone. Pathology was confirmed by hematopathologists at our institution. Patient and disease factors were analyzed for association with relapse-free survival (RFS) and overall survival (OS). Results: Median age of the cohort was 59 years, and median follow-up was 5.2 years. Ann Arbor stage was IE in 92%. Most common disease sites were stomach (50%), orbit (18%), non-thyroid head-and-neck (8%), skin (8%), and breast (5%). Median RT dose was 30 Gy. Five-year OS and RFS were 92% and 74%, respectively. Cumulative incidence of disease-specific death was just 1.1% by 5 years. Sixty patients (24%) developed relapse of disease; 10 were in the RT field. Crude rate of transformation to pathologically confirmed large-cell lymphoma was 1.6%. On multivariable analysis, primary disease site (P=.007) was independently associated with RFS, along with age (P=.04), presence of B-symptoms (P=.02), and International Prognostic Index risk group (P=.03). All disease sites except for head-and-neck had worse RFS relative to stomach. Conclusion: Overall and cause-specific survival are high in early-stage extra-nodal MZL treated with curative RT alone. In this large cohort of 244 patients, most patients did not experience relapse of MZL after curative RT; when relapses did occur, the majority were in distant sites. Stomach cases were less likely to relapse than other anatomic sites. Transformation to large-cell lymphoma was rare.

  18. Monoclonal Antibody Therapy in Treating Patients With Chronic Lymphocytic Leukemia, Lymphocytic Lymphoma, Acute Lymphoblastic Leukemia, or Acute Myeloid Leukemia

    Science.gov (United States)

    2013-06-03

    Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Splenic Marginal Zone Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma

  19. Primary extranodal marginal zone lymphoma of the uvea associated with massive diffuse epibulbar extension and focal infiltration of the optic nerve and meninges, clinically presented as uveitis masquerade syndrome: a case report.

    Science.gov (United States)

    Rasić, D M; Stanković, Z; Terzić, T; Kovacević, D; Koturović, Z; Marković, V

    2010-09-01

    To report a clinical, histopathological and immunohistochemical findings in a case of primary extranodal marginal zone lymphoma of the uvea associated with massive diffuse extraocular episcleral extension and focal infiltration of the optic nerve and meninges, clinically presented as longstanding uveitis masquerade syndrome. Interventional case reports with histopathological correlation. We describe a 80-year-old male patient with a 3-year history of chronic recurrent hypertensive (pan) uveitis associated with ocular pain, unresponsive to topical and systemic anti-inflammatory, immunosuppressive, antibiotic/antiviral and antiglaucomatous therapy. Because the eye was not salvageable with conservative treatment, enucleation of blind and painful eye was performed. Findings from histopathological and immunohistochemistry examination of the enucleated eye showed an extranodal marginal zone lymphoma of the uveal tract with massive epibulbar extension and optic nerve and meningeal penetration. During almost 3 years of clinical course and 6 months after the enucleation, there were no systemic manifestations of lymphoma, and patient has not required subsequent treatment. Primary lymphoproliferative lesions of the uvea, comprising the iris, ciliary body and choroid are very rare, associated with epibulbar extension extremely and with optic nerve and menigeal penetration exceptionally. Despite its rarity, primary lymphoma of the uvea should be included in the differential diagnosis particularly in older patients with longstanding recurrent uveitis.

  20. Genetically Engineered Lymphocytes, Cyclophosphamide, and Aldesleukin in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or Indolent B-Cell Non-Hodgkin Lymphoma

    Science.gov (United States)

    2014-08-04

    B-cell Chronic Lymphocytic Leukemia; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

  1. Bezafibrate and medroxyprogesterone acetate target resting and CD40L-stimulated primary marginal zone lymphoma and show promise in indolent B-cell non-Hodgkin lymphomas.

    Science.gov (United States)

    Hayden, Rachel E; Kussaibati, Racha; Cronin, Laura M; Pratt, Guy; Roberts, Claudia; Drayson, Mark T; Bunce, Christopher M

    2015-04-01

    B cell non-Hodgkin lymphomas (B-NHLs) are the most common adult hematological cancers and many remain incurable. Development of chemotherapy regimens is confounded by the prevalence of B-NHL in older, frailer patients and the chemo-protective tumor microenvironment. Although biological therapies such as rituximab have significantly improved outcomes and selective kinase inhibitors are showing promise, the rate of new drug discovery remains disappointing, the treatments expensive and long-term benefits uncertain. An alternative strategy is redeployment of available, inexpensive and non-toxic drugs. Here, we demonstrate the antiproliferative and mitochondrial superoxide (MSO) driven pro-apoptotic activities of bezafibrate (BEZ) and medroxyprogesterone acetate (MPA) against B-NHL cells, with a bias toward MZL, in the presence and absence of the microenvironmental signal CD40L. Our study is the first to confirm the presence of CD40L within the lymph node of B-NHL and its capacity to drive B-NHL proliferation. These findings implicate BEZ + MPA as a potential therapeutic strategy in B-NHL.

  2. Arsenic Trioxide in Treating Patients With Relapsed or Refractory Lymphoma or Leukemia

    Science.gov (United States)

    2013-01-31

    Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Prolymphocytic Leukemia; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

  3. Pembrolizumab Alone or With Idelalisib or Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Non-Hodgkin Lymphomas

    Science.gov (United States)

    2016-06-02

    Recurrent Chronic Lymphocytic Leukemia; Recurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Lymphoplasmacytic Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Nodal Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Recurrent Splenic Marginal Zone Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Refractory Follicular Lymphoma; Refractory Lymphoplasmacytic Lymphoma; Refractory Nodal Marginal Zone Lymphoma; Refractory Small Lymphocytic Lymphoma; Refractory Splenic Marginal Zone Lymphoma; Richter Syndrome; Waldenstrom Macroglobulinemia

  4. Bryostatin 1 Plus Vincristine in Treating Patients With Progressive or Relapsed Non-Hodgkin's Lymphoma After Bone Marrow or Stem Cell Transplantation

    Science.gov (United States)

    2013-01-09

    Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma

  5. Rituximab, Cyclophosphamide, Bortezomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Low-Grade Follicular Lymphoma, Waldenstrom Macroglobulinemia, or Mantle Cell Lymphoma

    Science.gov (United States)

    2016-04-13

    Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Nodal Marginal Zone Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Splenic Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia

  6. Rituximab and Interleukin-12 in Treating Patients With B-Cell Non-Hodgkin's Lymphoma

    Science.gov (United States)

    2013-08-23

    Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma

  7. Interleukin-12 in Treating Patients With Previously Treated Non-Hodgkin's Lymphoma or Hodgkin's Disease

    Science.gov (United States)

    2015-04-14

    Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

  8. Everolimus and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma

    Science.gov (United States)

    2016-04-18

    Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Splenic Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia

  9. Dendritic Cell Therapy, Cryosurgery, and Pembrolizumab in Treating Patients With Non-Hodgkin Lymphoma

    Science.gov (United States)

    2017-01-26

    Aggressive Non-Hodgkin Lymphoma; Indolent Non-Hodgkin Lymphoma; Recurrent Adult Non-Hodgkin Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mediastinal (Thymic) Large B-Cell Cell Lymphoma; Recurrent T-Cell Non-Hodgkin Lymphoma; Small Lymphocytic Lymphoma

  10. Flavopiridol in Treating Patients With Relapsed or Refractory Lymphoma or Multiple Myeloma

    Science.gov (United States)

    2016-06-27

    Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Multiple Myeloma; Splenic Marginal Zone Lymphoma; Stage I Multiple Myeloma; Stage II Multiple Myeloma; Stage III Multiple Myeloma; Waldenström Macroglobulinemia

  11. Iodine I 131 Tositumomab and Fludarabine Phosphate in Treating Older Patients Who Are Undergoing an Autologous or Syngeneic Stem Cell Transplant for Relapsed or Refractory Non-Hodgkin's Lymphoma

    Science.gov (United States)

    2014-08-04

    Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

  12. Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With HIV-Associated Non-Hodgkin or Hodgkin Lymphoma

    Science.gov (United States)

    2015-05-06

    Adult Nasal Type Extranodal NK/T-cell Lymphoma; AIDS-related Diffuse Large Cell Lymphoma; AIDS-related Diffuse Mixed Cell Lymphoma; AIDS-related Diffuse Small Cleaved Cell Lymphoma; AIDS-related Immunoblastic Large Cell Lymphoma; AIDS-related Lymphoblastic Lymphoma; AIDS-related Peripheral/Systemic Lymphoma; AIDS-related Small Noncleaved Cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; HIV-associated Hodgkin Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I AIDS-related Lymphoma; Stage II AIDS-related Lymphoma; Stage III AIDS-related Lymphoma; Stage IV AIDS-related Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

  13. Obinutuzumab, Venetoclax, and Lenalidomide in Treating Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

    Science.gov (United States)

    2017-03-01

    B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma; Grade 1 Follicular Lymphoma; Grade 2 Follicular Lymphoma; Grade 3a Follicular Lymphoma; Recurrent Burkitt Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Follicular Lymphoma; Recurrent Marginal Zone Lymphoma; Refractory Burkitt Lymphoma; Refractory Diffuse Large B-Cell Lymphoma; Refractory Follicular Lymphoma; Transformed Recurrent Non-Hodgkin Lymphoma

  14. Entospletinib and Obinutuzumab in Treating Patients With Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Non-Hodgkin Lymphoma

    Science.gov (United States)

    2017-07-24

    Anemia; B-Cell Prolymphocytic Leukemia; Fatigue; Fever; Grade 1 Follicular Lymphoma; Grade 2 Follicular Lymphoma; Grade 3a Follicular Lymphoma; Hairy Cell Leukemia; Lymphadenopathy; Lymphocytosis; Lymphoplasmacytic Lymphoma; Mantle Cell Lymphoma; Marginal Zone Lymphoma; Night Sweats; Recurrent Chronic Lymphocytic Leukemia; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Small Lymphocytic Lymphoma; Richter Syndrome; Splenomegaly; Thrombocytopenia; Weight Loss

  15. Yttrium Y 90 Ibritumomab Tiuxetan, Fludarabine, Radiation Therapy, and Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

    Science.gov (United States)

    2016-03-21

    B-cell Chronic Lymphocytic Leukemia; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

  16. Marginal Ice Zone: Biogeochemical Sampling with Gliders

    Science.gov (United States)

    2015-09-30

    ocean and base of marine food webs, are responding to changing conditions in the Arctic Ocean . The high-level project goals are to use underwater...observing array (Fig. 1). The glider sensor suite included temperature , temperature microstructure, salinity , oxygen, chlorophyll fluorescence, optical...presented at the Arctic Science Summit Week in Toyama, Japan, in April 2015 (Direct Observations of Ocean Variability Across the Arctic Marginal Ice Zone

  17. Lenalidomide and Combination Chemotherapy (DA-EPOCH-R) in Treating Patients With MYC-Associated B-Cell Lymphomas

    Science.gov (United States)

    2016-08-24

    Adult Grade III Lymphomatoid Granulomatosis; B-cell Chronic Lymphocytic Leukemia; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Progressive Hairy Cell Leukemia, Initial Treatment; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage 0 Chronic Lymphocytic Leukemia; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Chronic Lymphocytic Leukemia; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage II Chronic Lymphocytic

  18. Malignant lymphoma of the conjunctiva

    DEFF Research Database (Denmark)

    Kirkegaard, Marina M; Coupland, Sarah E; Prause, Jan U;

    2015-01-01

    Conjunctival lymphomas constitute 25% of all ocular adnexal lymphomas. The majority are B-cell non-Hodgkin lymphomas (NHLs) (98%), whereas conjunctival T-cell NHLs are rare (2%). The most frequent subtype of conjunctival B-cell lymphoma is extranodal marginal zone lymphoma (EMZL; 81%), followed b...

  19. FAU in Treating Patients With Advanced Solid Tumors or Lymphoma

    Science.gov (United States)

    2014-01-06

    Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell

  20. Genetically Modified T-cell Infusion Following Peripheral Blood Stem Cell Transplant in Treating Patients With Recurrent or High-Risk Non-Hodgkin Lymphoma

    Science.gov (United States)

    2017-01-27

    Adult Grade III Lymphomatoid Granulomatosis; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenström Macroglobulinemia

  1. Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma

    Science.gov (United States)

    2016-07-12

    Adult B Acute Lymphoblastic Leukemia; Adult T Acute Lymphoblastic Leukemia; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-Cell Lymphoma; Chronic Lymphocytic Leukemia; Cutaneous B-Cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Hepatosplenic T-Cell Lymphoma; Intraocular Lymphoma; Lymphomatous Involvement of Non-Cutaneous Extranodal Site; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Nodal Marginal Zone Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-Cell Leukemia/Lymphoma; Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides and Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Small Intestinal Lymphoma; Splenic Marginal Zone Lymphoma; T-Cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenstrom Macroglobulinemia

  2. Clinical analysis of voriconazole in treatment of invasive fungal pneumonia in marginal zone B-cell lymphoma%伏立康唑治疗边缘带B细胞淋巴瘤合并侵袭性真菌性肺炎的临床分析

    Institute of Scientific and Technical Information of China (English)

    刘景华; 周凡; 张晓琳; 李敏燕; 刘彦琴; 王吉刚

    2011-01-01

    目的 探讨伏立康唑在边缘带B细胞淋巴瘤应用氟达拉滨治疗过程中并发侵袭性真菌性肺炎的疗效.方法 回顾性分析边缘带B细胞淋巴瘤患者在应用氟达拉滨治疗过程中并发侵袭性真菌性肺炎,比较应用伏立康唑抗真菌治疗前后患者症状、血气分析、肺部影像学、真菌表面抗原等的改变.结果 氟达拉滨为基础方案化疗两个疗程后,出现侵袭性真菌性肺炎,其病程呈延缓性,在发病1个月后开始给予伏立康唑抗真菌治疗,治疗3d后临床症状改善,1周后血气分析改善,约2周真菌表面抗原滴度降低,约5周肺部炎性病变大部吸收.结论 伏立康唑在边缘带B细胞淋巴瘤应用氟达拉滨治疗过程中并发侵袭性真菌性肺炎中的疗效是确切的.%OBJECTIVE To investigate the clinical effect of voriconazole in treatment invasive fungal pneumonia patients with in marginal zone B-cell lymphoma. METHODS Retrospective analysis the change of symptoms, blood gas analysis, lung imaging and fungal surface antigens titer before and after voriconazole treatment invasive fungal pneumonia in marginal zone B-cell lymphoma. RESULTS Invasive fungal pneumonia appeared after two circles of fludarabine-based chemotherapy. Disease progress of invasive fungal pneumonia was slowly, voriconazole treatment invasive fungal pneumonia was started 1 month after onset. Clinical symptoms was improved after 3 days, blood gas analysis was improved after 1 week, fungal surface antigen titer was reduced after about 2 weeks, and lung imaging was obviously improved after about 5 weeks voriconazole treatment invasive fungal pneumonia. CONCLUSION The clinical effect of voriconazole treatment invasive fungal pneumonia in marginal zone B-cell lymphoma is exact.

  3. Lymphoma of the eyelid

    DEFF Research Database (Denmark)

    Svendsen, Frederik H; Heegaard, Steffen

    2017-01-01

    Lymphoma of the eyelid constitutes 5% of ocular adnexal lymphoma. In previously published cases, 56% of lymphomas of the eyelid are of B-cell origin and 44% are of T-cell origin. The most frequent B-cell lymphomas are extranodal marginal zone lymphoma (27 cases-14%) and diffuse large B-cell lymph......Lymphoma of the eyelid constitutes 5% of ocular adnexal lymphoma. In previously published cases, 56% of lymphomas of the eyelid are of B-cell origin and 44% are of T-cell origin. The most frequent B-cell lymphomas are extranodal marginal zone lymphoma (27 cases-14%) and diffuse large B...... chemotherapy with or without adjuvant treatment is the treatment of choice for high-grade or disseminated lymphomas. The majority of subtypes, especially low-grade subtypes, have a good prognosis with few recurrences or progression. Some subtypes, including mycosis fungoides, have a poorer prognosis...

  4. Nodal marginal zone B-cell lymphoma with monocional IgM:2 cases report and review of literatures%结内边缘带B细胞淋巴瘤伴有单克隆IgM增高两例并文献复习

    Institute of Scientific and Technical Information of China (English)

    王欢; 周小鸽; 熊梅; 王昭

    2009-01-01

    Objective To elucidate the clinical and pathological features, diagnosis, treatment and prognosis of nodal marginal zone B-cell lymphoma (NMZL). Methods 2 patients, with NMZL who has extremely elevated monoclonal IgM were analyzed and review were included. Results The common pathological diagnosis caused by the association of monoclonal gammopathy with indolent B-cell non-Hodgkin lymphomas was marginal zone lymphoma or B small cell lymphocytic lymphoma/B-cell chronic lymphocytic leukemia. According to our cases and literatures, the main distribution of involved sites in NMZL were lymph nodes, spleen and bone marrow. Sixty percent of the NMZL patients presented with advanced stage with, high risk of IPI. The diagnosis of NMZL was based on pathology of the lymph node. The proliferation and distribution of the differentiation monocytoid cell had a specified significance. Prognosis of early stage ( I or Ⅱ) NMZL were much better than that of advanced stage NMZL even the patients had received chemotherapy.Conclusion NMZL mainly involved lymph nodes, bone marrow and spleen, sporadically associated with the elevated monoclonal IgM. Most of the NMZL patients presented with advanced stage.The prognoses were poor.%目的 分析结内边缘带B细胞淋巴瘤(NMZL)伴有单克隆lgM增高病例的临床及病理特点、诊断、治疗及预后.方法 对2例NMZL病例进行分析并进行文献综述.结果 惰性B细胞淋巴瘤伴有单克隆免疫球蛋白升高,最常见的两种病理类型为NMZL和B-SLL/CLL.NMZL主要累及淋巴结、脾脏、骨髓,60%发病时为进展期,国际预后指数(IPI)评分为高危,诊断主要依据淋巴结病理,单核样B细胞增生及分布有重要的参考价值.Ⅰ和(或)Ⅱ期化疗疗效好,进展期疗效差.结论 NMZL主要累积淋巴结、脾脏、骨髓,町伴有单克隆IgM增多,发病时多处于疾病进展期,预后不佳.

  5. Report on recent advances on marginal zone lymphoma in the 54th ASH annual meeting%边缘区淋巴瘤的多面世界和研究进展:从2012年美国血液学会年会报道说起

    Institute of Scientific and Technical Information of China (English)

    李增军; 邱录贵

    2013-01-01

    边缘区淋巴瘤分为三类,它们在常见累及部位、病因、发病机制、分子细胞遗传学特点及预后等多方面存在差异.以2012年美国血液学会(ASH)年会关于边缘区淋巴瘤的报道为契机,参考会议摘要和近年的相关研究,介绍目前对该病三种亚型的认识和在病因、发病机制及诊断、鉴别诊断方面的研究进展.%Marginal zone lymphomas include three subgroups of lymphoma,with differences on etiology,pathogenesis,molecular cytogenetics,prognosis,as well as involved sites.Based on the reports from the latest ASH annual meeting,the present article introduces the uptodate understanding on the three subtypes of MZL.The recent advances on etioloty,pathogenesis,diagnosis and differential diagnosis were reviewed.

  6. Vorinostat and Decitabine in Treating Patients With Advanced Solid Tumors or Relapsed or Refractory Non-Hodgkin's Lymphoma, Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, or Chronic Myelogenous Leukemia

    Science.gov (United States)

    2014-08-26

    Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Blastic Phase Chronic Myelogenous Leukemia; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Secondary Acute Myeloid Leukemia; Splenic Marginal Zone Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma

  7. CD27 expression in the human splenic marginal zone : the infant marginal zone is populated by naive B cells

    NARCIS (Netherlands)

    Zandvoort, A; Lodewijk, ME; de Boer, NK; Dammers, PM; Kroese, FGM; Timens, W

    2001-01-01

    The splenic marginal zone of adult humans contains B cells, of which most express CD27, an antigen only recently identified as a marker for somatically, mutated memory B cells. We investigated whether and to which extent the developing marginal zone in infants arid children is populated by either

  8. Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant

    Science.gov (United States)

    2015-08-12

    Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Childhood Burkitt Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Grade III Lymphomatoid Granulomatosis; Childhood Immunoblastic Large Cell Lymphoma; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult

  9. The origin of marginal zone B cells in the rat

    NARCIS (Netherlands)

    Dammers, PM; de Boer, NK; Deenen, GJ; Nieuwenhuis, P; Kroese, FGM

    1999-01-01

    The marginal zone is a unique compartment that is only found in the spleen. Rat marginal zone B cells (MZ-B) can be distinguished from other B cells, e.g. recirculating follicular B cells (RF-B), by several phenotypic characteristics. Typically MZ-B cells are surface (s)IgM(hi), sIgD(lo) and CD45R(B

  10. Lenalidomide With or Without Rituximab in Treating Patients With Progressive or Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Prolymphocytic Leukemia, or Non-Hodgkin Lymphoma Previously Treated With Donor Stem Cell Transplant

    Science.gov (United States)

    2017-07-24

    Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Prolymphocytic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

  11. Rituximab in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant for Relapsed or Refractory B-cell Lymphoma

    Science.gov (United States)

    2015-11-23

    B-cell Adult Acute Lymphoblastic Leukemia; B-cell Childhood Acute Lymphoblastic Leukemia; B-cell Chronic Lymphocytic Leukemia; Childhood Burkitt Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenström Macroglobulinemia

  12. Bortezomib and Filgrastim in Promoting Stem Cell Mobilization in Patients With Non-Hodgkin Lymphoma or Multiple Myeloma Undergoing Stem Cell Transplant

    Science.gov (United States)

    2016-04-19

    Adult Grade III Lymphomatoid Granulomatosis; B-cell Chronic Lymphocytic Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Progressive Hairy Cell Leukemia, Initial Treatment; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular

  13. Rare Posterior Pharyngeal Mass: Atypical Marginal Zone Hyperplasia.

    Science.gov (United States)

    Eliçora, Sultan Şevik; Güven, Mehmet; Varli, Ali F; Yilmaz, Mahmut S; Alponat, Selin

    2016-03-01

    Cases of posterior pharyngeal masses are quite rare, and are typically derived from schwannoma or encephalocele, or are of vascular or infectious origin. They are clinically significant due to their tendency to cause airway obstruction. The aim of this study was to present a rare atypical marginal hyperplasia case of a posterior pharyngeal wall mass. A 10-year-old male was admitted to our clinic with dyspnea. A plane-surfaced 4 × 3 × 3 cm mass was observed on the posterior pharyngeal wall upon physical examination. The patient underwent magnetic resonance imaging and surgical treatment. Following excision of material from the patient's mass, a pathologic diagnosis of atypical marginal zone hyperplasia was made. Atypical marginal zone hyperplasia of the posterior pharyngeal wall has not yet been reported in the literature. Marginal zone hyperplasia associated with a lymphoproliferative disease should be considered when making differential diagnoses of posterior pharyngeal wall masses.

  14. 以冷凝集素综合征为首发表现的脾边缘区淋巴瘤一例%Splenic Marginal Zone Lymphoma With Cold-agglutination Syndrome as the First Manifestation:A Case Report

    Institute of Scientific and Technical Information of China (English)

    赵丽云

    2015-01-01

    Cold-agglutination syndrome is chronic hemolytic anemia induced by autoreactive agglutination of red cells and cold-induced factors.The disease can be primary and secondary , and it is always secondary to malignant proliferation of B -lymphocyte.This article made a case report of a patient with splenic marginal zone lymphoma ( SMZL) and cold-agglutination syndrome as the first manifestation .Abnormal dysplasia in lymph was noted in the myelography of the patient , with mainly mature and small lymphocytes , and short down was observed .The condition improved after three courses of treatment by RCHOP -21 regimen.%冷凝集素综合征是由于自身反应性红细胞凝集及冷诱导因素导致的慢性溶血性贫血性疾病,可分为原发性和继发性,后者常继发于恶性B淋巴细胞增生性疾病等。本文报道以冷凝集素综合征为首发表现的1例脾边缘区淋巴瘤( SMZL)患者,骨髓像见淋巴系异常增生,以成熟小淋巴细胞为主,可见短绒毛,经3个疗程RCHOP-21方案化疗后病情好转。

  15. Etoposide, Filgrastim, and Plerixafor in Improving Stem Cell Mobilization in Treating Patients With Non-Hodgkin Lymphoma

    Science.gov (United States)

    2016-09-15

    Adult Acute Lymphoblastic Leukemia in Remission; Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

  16. Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma

    Science.gov (United States)

    2017-01-26

    Adult Nasal Type Extranodal NK/T-Cell Lymphoma; Adult T-Cell Leukemia/Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-Cell Lymphoma; B Lymphoblastic Leukemia/Lymphoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Burkitt Leukemia; Central Nervous System Lymphoma; Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma; Diffuse Large B-Cell Lymphoma; Enteropathy-Associated T-Cell Lymphoma; Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Grade 1 Follicular Lymphoma; Grade 2 Follicular Lymphoma; Grade 3 Follicular Lymphoma; Hepatosplenic T-Cell Lymphoma; Lymphoplasmacytic Lymphoma; Mantle Cell Lymphoma; Mediastinal (Thymic) Large B-Cell Lymphoma; Mycosis Fungoides; Nasal Type Extranodal NK/T-Cell Lymphoma; Nodal Marginal Zone Lymphoma; Peripheral T-Cell Lymphoma, Not Otherwise Specified; Post-Transplant Lymphoproliferative Disorder; Primary Cutaneous Anaplastic Large Cell Lymphoma; Primary Effusion Lymphoma; Sezary Syndrome; Splenic Marginal Zone Lymphoma; Subcutaneous Panniculitis-Like T-Cell Lymphoma; Systemic Anaplastic Large Cell Lymphoma; T Lymphoblastic Leukemia/Lymphoma; Transformed Recurrent Non-Hodgkin Lymphoma

  17. Addition of rituximab to chlorambucil produces superior event-free survival in the treatment of patients with extranodal marginal-zone B-cell lymphoma: 5-year analysis of the IELSG-19 Randomized Study.

    Science.gov (United States)

    Zucca, Emanuele; Conconi, Annarita; Laszlo, Daniele; López-Guillermo, Armando; Bouabdallah, Reda; Coiffier, Bertrand; Sebban, Catherine; Jardin, Fabrice; Vitolo, Umberto; Morschhauser, Franck; Pileri, Stefano A; Copie-Bergman, Christiane; Campo, Elias; Jack, Andrew; Floriani, Irene; Johnson, Peter; Martelli, Maurizio; Cavalli, Franco; Martinelli, Giovanni; Thieblemont, Catherine

    2013-02-10

    Apart from localized gastric disease, there is no consensus on standard initial treatment of mucosa-associated lymphoid tissue lymphoma. The IELSG-19 study (Randomized Trial of Chlorambucil Versus Chlorambucil Plus Rituximab Versus Rituximab in MALT Lymphoma) was launched to compare chlorambucil alone versus chlorambucil plus rituximab in patients not previously given systemic anticancer therapy. Patients not responding to or not suitable for local therapy were eligible. In arm A, chlorambucil was given daily 6 mg/m(2) orally (PO) for 6 weeks. Responding patients and those with stable disease continued to be given daily chlorambucil 6 mg/m(2) PO for 14 consecutive days every 28 days for four cycles. In arm B, intravenous rituximab 375 mg/m(2) per day was added on days 1, 8, 15, 22, 56, 84, 112, and 140. After completion of the planned accrual, the protocol was amended to introduce a third arm with rituximab alone. We report the planned final analysis of the first two arms (113 patients in arm A and 114 in arm B). At a median follow-up of 62 months, the 5-year event-free survival (EFS) was significantly better for the patients treated in arm B (68% v 50%; P = .002) who, despite similar overall response rates (90% v 87%), achieved a higher complete remission rate (78% v 65%; P = .025). Progression-free survival was also improved but it did not reach statistical significance (P = .057). Five-year overall survival (OS) was 89% in both arms. Both treatments were well tolerated without unexpected toxicities. Both treatments were active; the better response rate and EFS obtained with the addition of rituximab did not translate into improved OS.

  18. Cellular Immunotherapy Following Chemotherapy in Treating Patients With Recurrent Non-Hodgkin Lymphomas, Chronic Lymphocytic Leukemia or B-Cell Prolymphocytic Leukemia

    Science.gov (United States)

    2016-07-29

    Post-transplant Lymphoproliferative Disorder; B-Cell Prolymphocytic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma; B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma; Recurrent Lymphoplasmacytic Lymphoma

  19. Heterogeneity of memory marginal zone B cells in the rat

    NARCIS (Netherlands)

    Hendricks, Jacobus

    2015-01-01

    The spleen is an important organ of the immune system. Like other lymphoid organs, the spleen is compartmentalized. Different compartments harbor different populations of lymphocytes, subpopulation of the white blood cells. One of these compartments in the spleen is the so-called marginal zone. Most

  20. Air-sea interactions in the marginal ice zone

    Directory of Open Access Journals (Sweden)

    Seth Zippel

    2016-03-01

    Full Text Available Abstract The importance of waves in the Arctic Ocean has increased with the significant retreat of the seasonal sea-ice extent. Here, we use wind, wave, turbulence, and ice measurements to evaluate the response of the ocean surface to a given wind stress within the marginal ice zone, with a focus on the local wind input to waves and subsequent ocean surface turbulence. Observations are from the Beaufort Sea in the summer and early fall of 2014, with fractional ice cover of up to 50%. Observations showed strong damping and scattering of short waves, which, in turn, decreased the wind energy input to waves. Near-surface turbulent dissipation rates were also greatly reduced in partial ice cover. The reductions in waves and turbulence were balanced, suggesting that a wind-wave equilibrium is maintained in the marginal ice zone, though at levels much less than in open water. These results suggest that air-sea interactions are suppressed in the marginal ice zone relative to open ocean conditions at a given wind forcing, and this suppression may act as a feedback mechanism in expanding a persistent marginal ice zone throughout the Arctic.

  1. Low-Dose Total Body Irradiation and Donor Peripheral Blood Stem Cell Transplant Followed by Donor Lymphocyte Infusion in Treating Patients With Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, or Multiple Myeloma

    Science.gov (United States)

    2015-10-30

    Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage II Multiple Myeloma; Stage III Multiple Myeloma; Testicular Lymphoma; Waldenström Macroglobulinemia

  2. Mediastinal gray zone lymphoma: clinico-pathological characteristics and outcomes of 99 patients from the Lymphoma Study Association

    Science.gov (United States)

    Sarkozy, Clémentine; Molina, Thierry; Ghesquières, Hervé; Michallet, Anne-Sophie; Dupuis, Jehan; Damotte, Diane; Morsschauser, Franck; Parrens, Marie; Martin, Laurent; Dartigues, Peggy; Stamatoullas, Aspasia; Hirsch, Pierre; Fabiani, Bettina; Bouabdallah, Krimo; da Silva, Maria Gomes; Maerevoet, Marie; Laurent, Camille; Coiffier, Bertrand; Salles, Gilles; Traverse-Glehen, Alexandra

    2017-01-01

    Mediastinal gray zone lymphoma, B-cell lymphomas with intermediate features between classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma, have not been well described in the literature. We report the clinical characteristics and outcomes of a large retrospective series of 99 cases centrally reviewed by a panel of hematopathologists, with a consensus established for the diagnosis. Cases were defined as classical Hodgkin lymphoma-like morphology (64.6%) with primary mediastinal B-cell lymphoma immunophenotype, primary mediastinal B-cell lymphoma-like morphology (30.3%) with classical Hodgkin lymphoma or composite (5.1%) (synchronous occurrence of classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma). The median age was 32 years (13–83 years); 55% were women. Thirteen of 81 evaluable cases (16%) were Epstein-Barr virus-positive. Twenty-eight percent of patients presented primary refractory disease (progression under first-line treatment or relapse within one year). The 3-year event-free and overall survival rates were 63% and 80%, respectively. Patients treated with a standard regimen (RCHOP/ABVD) had worse event-free survival (P=0.003) and overall survival (P=0.02) than those treated with a dose-intensive chemotherapy (high-dose RCHOP/escalated BEACOPP). Rituximab added to chemotherapy was not associated with better event-free survival (P=0.55) or overall survival (P=0.88). Radiotherapy for patients in complete remission had no impact on event-free survival. In multivariate prognostic analysis, ECOG-PS and anemia were the strongest factors associated with a shorter event-free survival and overall survival, respectively. In conclusion, this report describes the largest series of mediastinal gray zone lymphoma. Our data suggest that a dose-intensive treatment might improve the outcome of this rare and aggressive disease. PMID:27758822

  3. Bortezomib, Rituximab, and Dexamethasone With or Without Temsirolimus in Treating Patients With Untreated or Relapsed Waldenstrom Macroglobulinemia or Relapsed or Refractory Mantle Cell or Follicular Lymphoma

    Science.gov (United States)

    2017-01-31

    Cognitive Side Effects of Cancer Therapy; Fatigue; Neurotoxicity Syndrome; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Therapy-Related Toxicity; Waldenstrom Macroglobulinemia

  4. A clinical study of chromosome translocations in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in Chinese patients%中国人黏膜相关淋巴组织结外边缘区淋巴瘤染色体易位的临床研究

    Institute of Scientific and Technical Information of China (English)

    董格红; 冯振博; 高子芬; 叶洪涛; 王桂秋; 宫丽平; 王晋芬; 莫祥兰; 刘红刚; 董丽娜; 周英琼; 张雪梅

    2009-01-01

    Objective To investigate the genetic aberrations in extranodal marginal zone lymphoma of mueosa-associated lymphoid tissue (MALT) lymphomas from different sites of the body in Chinese patients. Methods Two hundred and seventeen paraffin-embedded MALT lymphoma specimens from 11 major sites were studied with interphase fluorescence in situ hybridization (FISH) to detect t(11; 18) (q21;q21)/API2-MALT1, t(1; 14) (p22; q32)/IGH-BCL10, (14; 18) (q32; q21)/IGH-MALT1 and BCL6 gene involved chromosome translocations. Results These translocations were mutually exclusive and detected in 21% (46/217) of the cases, including t(11;18) (q21;q21) API2-MALT1 13% (29/217), t (1;14)(p22 ;q32) IGH-BCLIO in 1% (3/217), t(14;18) (q32;q21) IGH-MALT1 1% (2/217), BCL6 involved translocation in 2% (4/217) and IGH-unknown translocation partner in 4% (8/217). t(11; 18) (q21;q21)API2-MALT1 was found with the highest frequency in MALT lymphoma from lungs (47% , 8/17) and small intestine (29%, 4/14), followed by salivary gland (17%, 1/6), stomach (14%, 12/84) and ocular adnexae (6% , 4/68). t(1 ;14) (p22;q32) was only detected in lungs (12%, 2/17) and stomach (1%, 1/84). t(14;18) (q32;q21) was mainly detected in lungs (6%, 1/17) and ocular adnexae (2%, 1/68). BCL6 gene involved translocation was detected in salivary gland (17% , 1/6) and stomach (4%, 3/84). Conclusions It is demonstrated that the four translocatidns occur with markedly variable frequencies in MALT lymphoma of different sites in Chinese patients. The distributions of these chromosome translocations in Chinese patients are slightly different from those reported in western patients.%目的 探讨中国人不同部位黏膜相关淋巴组织结外边缘区淋巴瘤(MALTL)中分子遗传学异常的发生情况.方法 应用间期荧光原位杂交(FISH)方法,检测217例不同部位MALTL的t(11;18)(q21;q21)/API2-MALT1、t(1;14)(p22;q32)/IGH-BCL10、t(14;18)(q32;q21)/IGH-MALT1和涉及BCL6基因的染色体易位.结果 染色

  5. 胸腺原发黏膜相关淋巴组织结外边缘区B细胞淋巴瘤的临床病理特征%Clinicopathologic features of primary thymic extranodal marginal zone B-cell lymphoma of mucosaassociated lymphoid tissue type

    Institute of Scientific and Technical Information of China (English)

    孙璐; 石怀银; 韦立新

    2012-01-01

    Objective To study the clinicopathologic features of primary thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT). Methods The clinical and pathologic findings were evaluated in 3 cases of biopsy confirmed thymic MALT lymphoma. The clincopathologic features,treatment and prognosis were discussed and literatures reviewed.Results One male and two female patients presented with asymptomatic mediastinal masses with a history of Sj(o)gren syndrome.They were aged 36,35 and 41 years respectively,and only one patient had B symptoms.Grossly,all three tumors were encapsulated and had multiple variable-sized cysts on cut-surface.Histopathologically,the normal thymic lobular architecture was effaced by abnormal dense lymphoid infiltration. Prominent lymphoepithelial lesions were formed by centrocyte-like cells infiltrating and expanding Hassall's corpuscles and epithelial cyst lining. All cases showed apparent plasmacytic differentiation.Immunhistochemically,the tumor cells were positive for CD20,CD79a,bcl-2 and negative for CD3,CD5,cyclin D1,CD43,CD10,bcl-6,and CD23.The plasma cells showed kappa light chain restriction.Immunoglobulin heavy chain rearrangement in three cases was confirmed by PCR.All patients were at early stage and received routine chemotherapy with or without radiothcrapy aftcr surgical rcmoval.All patients achieved complete remission with 24,18 and 3 months follow-up,respectively. Conclusions Primary thymic MALT lymphoma may be a rare distinctive lymphoma. It can be diagnosed by HE and immunohistochemical study and should be differentiated from reactive lymphoid proliferation,other types of lymphoma and mediastinal thymoma.%目的 探讨胸腺原发黏膜相关淋巴组织(MALT)结外边缘区B细胞淋巴瘤的临床病理特征.方法 对3例经于术切除、病理证实的胸腺原发MALT淋巴瘤病例进行临床病理分析,并复习文献,讨论其临床、病理特征、治疗和预后.结果 3

  6. 原发性皮肤边缘区B细胞淋巴瘤的BCL10表达与染色体异常%BCL10 expression and chromosomal aberration in primary cutaneous marginal zone B-cell lymphoma

    Institute of Scientific and Technical Information of China (English)

    李百周; 孔蕴毅; 杨文涛; 周晓燕; 范月珍; 陆洪芬; 施达仁

    2008-01-01

    目的 探讨原发性皮肤边缘区B细胞淋巴瘤(PCMZL)中BCL10蛋白的表达和相关染色体的异常.方法 收集17例PCMZL,用免疫组化检测BCL10的表达,用荧光原位杂交(FISH)的方法分别检测API2-MALT1、BCL10、MALT1和IgH基因的异常.结果 在17例PCMZL中,BCL10的阳性率为94.1%(16/17),其中细胞质阳性率为64.7%(11/17),细胞核阳性率为29.4%(5/17).在FISH检测中,所有病例都不存在t(11;18),t(1;14)和t(14;18)染色体异常.与其他部位的MALT淋巴瘤相比较,在PCMZL中染色体易位的发生率不常见,可能这些遗传学异常不是PCMZL发生中的重要因素,而有其他目前未知的因素参与肿瘤的发生.结论 BCL10的核表达与是否出现上述的染色体异常无关,是否代表更具侵袭性的一种预后标记,尚需长期随访观察.%Objective To study the expression of BCL10 and associated chromosomal aberration in primary cutaneous marginal zone B-cell lymphoma (PCMZL). Methods Tissue specimens were collected from 17 patients with PCMZL. Immunohistochemistry was used to detect the expression of BCL10. Fluorescence in situ hybridization (FISH) was performed to examine the presence of API2-MALT1 fusion gene and chromosomal aberration in BCL10, MALT1 as well as IgH genes in these cases. Results Of these patients,94.1% (16/17) expressed BCL10 protein. The cytoplasmic expression of BCL10 was observed in 64.7% (11/17) of the patients, and nuclear expression in 29.4% (5/17). As shown by FISH test, neither API2-MALT1 fusion gene nor chromosomal aberration in BCL10, MALT1 or IgH genes was present in these patients. Conclusions Compared with MALT lymphomas originating from tissues other than skin, PCMZL is uncommonly associated with chromosomal abnormalities; it is possible that there are unknown factors contributing to its tumorigenesis. Nuclear BCL10 is unrelated to the presence of chromosomal aberration in BCL10, MALT1 or IgH genes. Further follow-up is required to clarify the

  7. Ice, Ocean and Atmosphere Interactions in the Arctic Marginal Ice Zone

    Science.gov (United States)

    2015-09-30

    release; distribution is unlimited. DRI TECHNICAL PROGRAM: Emerging Dynamics Of The Marginal Ice Zone Ice, Ocean and Atmosphere Interactions in the... Arctic Marginal Ice Zone Year 4 Annual Report Jeremy Wilkinson British Antarctic Survey phone: 44 (0)1223 221489 fax: 44 (0) 1223...global) scientific team in order to better understand the ocean , sea ice and atmosphere interaction within the marginal ice zone

  8. Controllability Analysis for Operation Margin of Zone 3 Impedance Relay

    Science.gov (United States)

    Li, Shenghu; Yorino, Naoto; Zoka, Yoshifumi

    Undesirable operation of zone 3 impedance relay (mho relays) is a possible factor for causing cascading failure as seen in several previous large scale blackouts, where power flow redistribution and power swing caused by outage or switching operations satisfy the condition for the relay operation. So far, the condition itself has not fully been investigated, and therefore, there has been little attempt to avoid the relay operation by means of direct power flow control. This paper analyzes the condition for zone 3 relay operation from the viewpoint of its sensitivity to power flow. An operating margin for security is defined for each relay to carry out effective monitoring. It is newly pointed out that undesirable operation can be effectively avoided by reactive power controls as well as real power controls. The method to compute the operation margin is also given through the analysis of the optimal Var location to control the operation margin. Effectiveness of the proposed method is demonstrated using the IEEE test systems.

  9. Microcirculatory remodeling in marginal zone of duodenal ulcer after bleeding

    Directory of Open Access Journals (Sweden)

    Sulayeva О.N.

    2009-01-01

    Full Text Available To estimate objectively vessels network remodeling in duodenal mucosa after ulcer bleeding the morphometric analysis of marginal ulcer zone biopsies was performed in 32 patients. It was shown that reparation is accompanied with chronic inflammation and acute alteration of microcirculation. Injection hemostasis led to enhancement of microcirculation, development of edema and ischemic alteration of mucosal tissues. Acute neutrophilic infiltration during 1 day was changed on 3 day with granular tissue development and angiogenesis stimulation. Intensification and prolongation of angiogenesis paral-leled with lymphocytes infiltration after 7 days resulted to villi dysmorphogenesis and changes in cellular content of intestinal epithelium.

  10. Seismic exploration noise reduction in the Marginal Ice Zone.

    Science.gov (United States)

    Tollefsen, Dag; Sagen, Hanne

    2014-07-01

    A sonobuoy field was deployed in the Marginal Ice Zone of the Fram Strait in June 2011 to study the spatial variability of ambient noise. High noise levels observed at 10-200 Hz are attributed to distant (1400 km range) seismic exploration. The noise levels decreased with range into the ice cover; the reduction is fitted by a spreading loss model with a frequency-dependent attenuation factor less than for under-ice interior Arctic propagation. Numerical modeling predicts transmission loss of the same order as the observed noise level reduction and indicates a significant loss contribution from under-ice interaction.

  11. Marginal Ice Zone Processes Observed from Unmanned Aerial Systems

    Science.gov (United States)

    Zappa, C. J.

    2015-12-01

    Recent years have seen extreme changes in the Arctic. Marginal ice zones (MIZ), or areas where the "ice-albedo feedback" driven by solar warming is highest and ice melt is extensive, may provide insights into the extent of these changes. Furthermore, MIZ play a central role in setting the air-sea CO2 balance making them a critical component of the global carbon cycle. Incomplete understanding of how the sea-ice modulates gas fluxes renders it difficult to estimate the carbon budget in MIZ. Here, we investigate the turbulent mechanisms driving mixing and gas exchange in leads, polynyas and in the presence of ice floes using both field and laboratory measurements. Measurements from unmanned aerial systems (UAS) in the marginal ice zone were made during 2 experiments: 1) North of Oliktok Point AK in the Beaufort Sea were made during the Marginal Ice Zone Ocean and Ice Observations and Processes EXperiment (MIZOPEX) in July-August 2013 and 2) Fram Strait and Greenland Sea northwest of Ny-Ålesund, Svalbard, Norway during the Air-Sea-Ice Physics and Biogeochemistry Experiment (ASIPBEX) April - May 2015. We developed a number of new payloads that include: i) hyperspectral imaging spectrometers to measure VNIR (400-1000 nm) and NIR (900-1700 nm) spectral radiance; ii) net longwave and net shortwave radiation for ice-ocean albedo studies; iii) air-sea-ice turbulent fluxes as well as wave height, ice freeboard, and surface roughness with a LIDAR; and iv) drone-deployed micro-drifters (DDµD) deployed from the UAS that telemeter temperature, pressure, and RH as it descends through the atmosphere and temperature and salinity of the upper meter of the ocean once it lands on the ocean's surface. Visible and IR imagery of melting ice floes clearly defines the scale of the ice floes. The IR imagery show distinct cooling of the skin sea surface temperature (SST) as well as an intricate circulation and mixing pattern that depends on the surface current, wind speed, and near

  12. Novel insights into the molecular pathogenesis of gastric MALT lymphoma

    OpenAIRE

    2010-01-01

    Gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) represents a distinct class of extranodal lymphoma that evolves against a background of chronic inflammation induced by persistent infection with the bacterium Helicobacter pylori. In its early stages, MALT lymphoma is an antigen-dependent disease characterised by an indolent clinical course and in most cases is treatable by antibiotic eradication therapy alone. Low grade MALT lymphomas c...

  13. DRI Technical Program: Emerging Dynamics of the Marginal Ice Zone Ice, Ocean and Atmosphere Interactions in the Arctic Marginal Ice Zone. Year 3 Annual Report

    Science.gov (United States)

    2014-09-30

    and Atmosphere Interactions in the Arctic Marginal...ice mass balance buoys (IMBs), wave buoys (WBs), and Automatic Weather Stations (AWS) in the region north of Alaska. The now deployed arrays have a... Arctic Marginal Ice Zone. Year 3 Annual Report 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e

  14. Treatment options for ocular adnexal lymphoma (OAL

    Directory of Open Access Journals (Sweden)

    Victoria Mary Lendrum Cohen

    2009-11-01

    Full Text Available Victoria Mary Lendrum CohenSt. Bartholomew’s and Moorfields Eye Hospital, London UKAbstract: Most lymphomas that involve the ocular adnexal structure are low grade, B cell, non-Hodgkin’s lymphomas. The treatment depends upon the grade and stage of the disease. High grade lymhoma requires treatment with systemic chemotherapy whereas the localized low grade (extranodal marginal zone lymphoma can be successfully managed with local radiotherapy. Chlamydia psittaci infection is associated with low grade ocular lymphoma; however there is wide geographic variation in the strength of this association. Blanket antibiotic therapy is not advised unless there is proof of an infective agent. The monoclonal antibody, rituximab, may be successful for CD20 positive lymphoma, although it is likely that rituximab will have better long-term results when used in combination with systemic chemotherapy.Keywords: ocular adnexal lymphoma, mucosa associated lymphoid tissue, extranodal marginal zone lymphoma, Chlamydia psittaci, rituximab, radiotherapy, chemotherapy

  15. Marginal zone B-cells, a gatekeeper of innate immunity.

    Science.gov (United States)

    Zouali, Moncef; Richard, Yolande

    2011-01-01

    To maintain the integrity of an organism constantly challenged by pathogens, the immune system is endowed with a variety of cell types. B lymphocytes were initially thought to only play a role in the adaptive branch of immunity. However, a number of converging observations revealed that two B-cell subsets, marginal zone (MZ) and B1 cells, exhibit unique developmental and functional characteristics, and can contribute to innate immune responses. In addition to their capacity to mount a local antibody response against type-2 T-cell-independent (TI-2) antigens, MZ B-cells can participate to T-cell-dependent (TD) immune responses through the capture and import of blood-borne antigens to follicular areas of the spleen. Here, we discuss the multiple roles of MZ B-cells in humans, non-human primates, and rodents. We also summarize studies - performed in transgenic mice expressing fully human antibodies on their B-cells and in macaques whose infection with Simian immunodeficiency virus (SIV) represents a suitable model for HIV-1 infection in humans - showing that infectious agents have developed strategies to subvert MZ B-cell functions. In these two experimental models, we observed that two microbial superantigens for B-cells (protein A from Staphylococcus aureus and protein L from Peptostreptococcus magnus) as well as inactivated AT-2 virions of HIV-1 and infectious SIV preferentially deplete innate-like B-cells - MZ B-cells and/or B1 B-cells - with different consequences on TI and TD antibody responses. These data revealed that viruses and bacteria have developed strategies to deplete innate-like B-cells during the acute phase of infection and to impair the antibody response. Unraveling the intimate mechanisms responsible for targeting MZ B-cells in humans will be important for understanding disease pathogenesis and for designing novel vaccine strategies.

  16. Marginal zone B-cells, a gatekeeper of innate immunity

    Directory of Open Access Journals (Sweden)

    Moncef eZOUALI

    2011-12-01

    Full Text Available To maintain the integrity of an organism constantly challenged by pathogens, the immune system is endowed with a variety of cell types. B-lymphocytes were initially thought to only play a role in the adaptative branch of immunity. However, a number of converging observations revealed that two B-cell subsets, marginal zone (MZ and B1 cells, exhibit unique developmental and functional characteristics, and can contribute to innate immune responses. In addition to their capacity to mount local antibody response against type 2 T-independent (TI-2 antigens, MZ B-cells can participate to T-dependent (TD immune response through the capture and import of blood-borne antigens to follicular areas of the spleen. Here, we discuss the multiple roles of MZ B-cells in rodents and primates. We also summarize studies —performed in transgenic mice expressing fully human antibodies on their B-cells and macaques whose infection with Simian Immunodeficiency Virus (SIV represents a suitable model for HIV-1 infection in humans— showing that infectious agents have developed strategies to subvert MZ B-cell functions. In these two experimental models, we observed that two microbial superantigens for B-cells (protein A from Staphylococcus aureus and protein L from Peptostreptococcus magnus as well as inactivated AT-2 virions of HIV-1 and infectious SIV preferentially deplete innate-like B-cells —MZ B-cells and/or B1 B-cells— with different consequences on TI and TD antibody responses. These data revealed that viruses and bacteria have developed strategies to deplete innate-like B-cells during the acute phase of infection and to impair the antibody response. Unraveling the intimate mechanisms responsible for targeting MZ B-cells in humans will be important for understanding disease pathogenesis and for designing novel vaccine strategies.

  17. Presence of bluetongue virus in the marginal zone of the spleen in acute infected sheep.

    Science.gov (United States)

    Lee, Fan; Chen, Jiun-Liang; Lin, Chun-Ming; Wang, Fun-In

    2011-08-26

    Bluetongue virus, a member of the genus Orbivirus of the family Reoviridae, is the causative agent of bluetongue, which is a non-contagious Culicoides mediated blood-borne disease. The present study characterizes the pathogenicity of a Taiwan prototype BTV2/KM/2003 in Corriedale sheep inoculated subcutaneously into the ear pinna. Histologically, multifocal petechiated hemorrhage, with mild to moderate inflammation and edema, were present in the contralateral ear pinna, tongue, and facial skin, without remarkable lesions in lymphoid organs. By days post-infection (DPI) 7, viral VP7 antigen, detected by immunohistochemistry, presented in the spleen, chiefly located in the outer rim of macrophages bordering the marginal zone and red pulp, and T lymphocytes of the red pulp. By DPI 11, viral signals shifted from the marginal zone to macrophages and small lymphocytes within follicles of the spleen. In situ hybridization with VP7 gene probe detected strong signals in the spleen, chiefly spanning the whole width of 5-10 cell thickness of the marginal zone, including the marginal zone macrophages and marginal zone B cells, as well as macrophages of sheathed capillaries in the red pulp. This study demonstrates molecular as well as morphologic evidence of the presence of bluetongue virus in the marginal zone of the spleen, most likely associated with viremia in acute infection, as previously demonstrated by the authors.

  18. DETERMINATION OF MARGINALLY STABLE ZONE OF GAS-SOLID MAGNETICALLY FLUIDIZED BEDS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The void fluctuation of magnotically fluidized beds was analyzed and their maginally stable zone was determined. The analysis was based on the two-phase model of magnetically fluidized bed and wave theory. The marginally stable zone determined by this paper matches well with the experimental results.

  19. The margin between Senja and Spitsbergen fracture zones: Implications from plate tectonics

    Science.gov (United States)

    Myhre, Annik M.; Eldholm, Olav; Sundvor, Eirik

    1982-10-01

    Analysis of multichannel seismic data from the continental margin off Svalbard between the Senja and Spitsbergen fracture zones suggests that the transition between continental and oceanic crust is located at or close to the Hornsund Fault Zone. In the Late Paleocene/Early Eoeene (57 m.y.) the region between Svalbard and Northeast-Greenland was subjected to regional shear movements associated with a transform system between the young Lofoten-Greenland Basin and the Arctic Ocean. Approximately 50 m.y. ago the spreading axis migrated to the northeast creating a deep basin north of the Greenland-Senja Fracture Zone forming the passive margin between Bear Island and 76.5°N. North of 76.5°N the regional transform was maintained. At the time of the main reorganization of relative plate motion (36 m.y.) the northern margin evolved. A continental fragment was possibly cut off from the Svalbard margin forming a small microcontinent. The microcontinent appears as the submarine ridge which has been associated with the Hovgaard Fracture Zone. It is suggested that the sediments west of the Hornsund Fault Zone are not older than Eocene in the south and mid-Oligocene in the north. The position of the spreading axis has greatly influenced the margin sedimentation.

  20. Primary mucosa-associated lymphoid tissue thyroid lymphoma: a rare thyroid neoplasm of extrathyroid origin

    Directory of Open Access Journals (Sweden)

    Dimitrios Hadjidakis

    2012-01-01

    Full Text Available Primary thyroid lymphoma is a rare malignancy, representing 2-8% of all thyroid malignancies and 1-2% of all extranodal lymphomas. The majority of cases concern non-Hodgkin`s lymphoma of B cell origin, following by Hodgkin’s disease, T cell lymphomas and rarely marginal zone B-cell mucosa-associated lymphoid tissue (MALT lymphomas. MALT lymphomas have been associated with long-standing autoimmune Hashimoto`s thyroiditis. We present the case of a 44-years-old woman with thyroid MALT lymphoma in the background of multinodular goiter of autoimmune origin.

  1. {sup 111}In-DOTA-dPhe{sup 1}-Tyr{sup 3}-octreotide, {sup 111}In-DOTA-lanreotide and {sup 67}Ga citrate scintigraphy for visualisation of extranodal marginal zone B-cell lymphoma of the MALT type: a comparative study

    Energy Technology Data Exchange (ETDEWEB)

    Li, Shuren; Kurtaran, Amir; Li, Mei; Traub-Weidinger, Tatjana; Kienast, Oskar [Department of Nuclear Medicine, University of Vienna, Waehringer Guertel 18-20, 1090, Vienna (Austria); Schima, Wolfgang [Department of Nuclear Medicine, University of Vienna, Waehringer Guertel 18-20, 1090, Vienna (Austria); Department of Radiodiagnostics, University of Vienna (Austria); Angelberger, Peter [Research Center Seibersdorf (Austria); Virgolini, Irene [Institute for Nuclear Medicine, Vienna Hospital Lainz (Austria); Ludwig-Boltzman Institute for Nuclear Medicine, Vienna (Austria); Raderer, Markus [Department of Internal Medicine I, Division of Oncology, University of Vienna (Austria); Dudczak, Robert [Department of Nuclear Medicine, University of Vienna, Waehringer Guertel 18-20, 1090, Vienna (Austria)

    2003-08-01

    Somatostatin receptor (SSTR) scintigraphy and gallium-67 citrate ({sup 67}Ga) scintigraphy have been used for visualisation of Hodgkin's lymphoma and non-Hodgkin's lymphoma. However, experience with B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type is very limited. The aim of this study was to prospectively compare the {sup 67}Ga scintigraphy results with those obtained by {sup 111}In-DOTA-dPhe{sup 1}-Tyr{sup 3}-octreotide ({sup 111}In-DOTA-TOCT) and {sup 111}In-DOTA-lanreotide ({sup 111}In-DOTA-LAN) scintigraphy in patients with proven MALT-type lymphoma. Comparative scintigraphic examinations using {sup 67}Ga, {sup 111}In-DOTA-TOCT and {sup 111}In-DOTA-LAN were performed in 18 patients (11 female and 7 male, median age 64{+-}15 years) with histologically verified MALT-type lymphomas of various origin. Planar and single-photon emission tomography imaging acquisitions were performed after injection of a mean dose of 185{+-}26 MBq {sup 67}Ga and 165{+-}20 MBq {sup 111}In-DOTA-TOCT or {sup 111}In-DOTA-LAN. All scintigraphic results were correlated with other conventional examinations including gastroscopy, colonoscopy, endosonoscopy, ophthalmologic investigation, CT of the thorax and abdomen and bone marrow biopsy. This comparative study showed that {sup 67}Ga scintigraphy found abnormalities in 10 of 16 patients (63%) and detected 18 of 31 clinically involved sites (58%), but was false positive in three patients. {sup 111}In-DOTA-TOCT found abnormalities in 9 of 15 patients (60%) and detected 15 of 27 clinical lesions (56%); it was false positive in two patients. {sup 111}In-DOTA-LAN scintigraphy showed abnormalities in 7 of 11 patients (64%) and found 12 of 22 clinical lesions (55%). False-positive {sup 111}In-DOTA-LAN scan results were found in two patients. For supra-diaphragmatic lesions, {sup 67}Ga scintigraphy detected 12 of 16 sites (75%). {sup 111}In-DOTA-TOCT scintigraphy revealed 7 of 15 lesions (47%). {sup 111}In

  2. Development of autoimmunity in lymphoma.

    Science.gov (United States)

    Jardin, Fabrice

    2008-03-01

    Development of lymphoproliferative diseases during the course of autoimmune and chronic inflammatory conditions is well established. Conversely, development of clinical or biological signs of autoimmunity at the time of the diagnosis of lymphoma or during its course indicates that lymphoma and autoimmune manifestations may constitute two faces of the same process. The aim of this review is to describe autoimmune manifestations related to non-Hodgkin's lymphoma and Hodgkin's lymphoma, their specificity according to the lymphoma subtype and their physiopathological signification. Lymphoma-related autoimmune manifestations include mainly skin diseases, hematological manifestations, rheumatic diseases and renal lesions. Despite the lack of studies providing a systematic prospective assessment, autoimmune manifestations are observed in all lymphoma subtypes and seem particularly prevalent in marginal-zone lymphoma and T-cell lymphoma. Autoimmune manifestation's physiopathology may implicate production of autoantibodies by CD5-positive autoreactive B cells, a loss of immune tolerance, an alteration of the Fas/Fas-ligand pathway and/or a chronic antigenic stimulation. Monoclonal antibodies (including rituximab, Campath-1H or epratuzumab) constitute the most promising approach to treat lymphoma-related immune disorders.

  3. Class-switched marginal zone B cells in spleen have relatively low numbers of somatic mutations

    NARCIS (Netherlands)

    Hendricks, Jacobus; Visser, Annie; Dammers, Peter M.; Burgerhof, Johannes G. M.; Bos, Nicolaas A.; Kroese, Frans G. M.

    2011-01-01

    The vast majority of rodent splenic marginal zone (MZ)-B cells are naive IgM(+) cells. A small fraction of these MZ-B cells carry mutated V-genes, and represent IgM(+) memory MZ-B cells. Here we reveal further heterogeneity of B cells with a MZ-B cell phenotype, by providing evidence for the existen

  4. Meiofaunal distribution across the oxygen minimum zone of continental margin, North East Arabian Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Ansari, Z.A.; Badesab, S.; Singh, R.; Kitazato, H.

    A quantitative study of metazoan meiofauna across the oxygen minimum zone (OMZ) of continental margin in the N-E Arabian Sea in the depth range 500-1965 m was carried out in September-November 2008. Bottom water oxygen and sediment organic carbon...

  5. On the deglaciation chronology of the Palivere ice-marginal zone, northern Estonia

    Directory of Open Access Journals (Sweden)

    Leili Saarse

    2012-07-01

    Full Text Available This paper presents new bio-, litho- and chronostratigraphical evidence from two adjacent sediment sequences of the Tõdva and Saku basins, northern Estonia that refine the age estimate of the Palivere ice-marginal zone and the deglaciation history of Estonia. Previouspalynological studies demonstrated the presence of late-glacial sediments in the area; however, those sections were not dated, and their ages were poorly constrained. New accelerator mass spectrometry (AMS 14C dates show that sedimentation in the Tõdva basin started at approximately 13 200 cal yr BP. Therefore, because the studied sitesare located at the distal part of this zone, we infer that this age represents the minimum timing of the ice retreat from the Palivere ice-marginal zone.

  6. Slow recovery of follicular B cells and marginal zone B cells after chemotherapy : implications for humoral immunity

    NARCIS (Netherlands)

    Zandvoort, A; Lodewijk, ME; Klok, PA; Dammers, PM; Kroese, FGM; Timens, W

    2001-01-01

    Although most chemotherapeutic agents are known to cause primarily reduction or suppression of immune responses, surprisingly little is known about the influence of cytostatic agents on lymphoid tissue compartments such as the splenic marginal zone. The marginal zone plays an important role in the d

  7. Ophthalmic lymphoma: epidemiology and pathogenesis.

    Science.gov (United States)

    Sjö, Lene Dissing

    2009-02-01

    With a lifetime risk of 1% and 700 new cases per year, Non-Hodgkin lymphoma (NHL) is the seventh most frequent type of cancer in Denmark. The incidence of NHL has increased considerably in Western countries over the last decades; consequently, NHL is an increasing clinical problem. Ophthalmic lymphoma, (lymphoma localized in the ocular region, i.e. eyelid, conjunctiva, lacrimal sac, lacrimal gland, orbit, or intraocularly) is relatively uncommon, accounting for 5%-10% of all extranodal lymphomas. It is, however, the most common orbital malignancy. The purpose of this thesis was to review specimens from all Danish patients with a diagnosis of ophthalmic lymphoma during the period 1980-2005, in order to determine the distribution of lymphoma subtypes, and the incidence- and time trends in incidence for ophthalmic lymphoma. Furthermore, an extended analysis of the most frequent subtype, extranodal marginal zone lymphoma (MALT lymphoma), was done to analyse clinical factors and cytogenetic changes with influence on prognosis. A total of 228 Danish patients with a biopsy-reviewed verified diagnosis of ocular adnexal-, orbital-, or intraocular lymphoma were identified. We found that more than 50% of orbital- and ocular adnexal lymphomas were of the MALT lymphoma subtype, whereas diffuse large B-cell lymphoma (DLBCL) predominated intraocularly (Sjo et al. 2008a). Furthermore, lymphoma arising in the lacrimal sac was surprisingly predominantly DLBCL (Sjo et al. 2006). Incidence rates were highly dependent on patient age. There was an increase in incidence rates for the whole population from 1980 to 2005, corresponding to an annual average increase of 3.4% (Sjo et al. 2008a). MALT lymphoma arising in the ocular region was found in 116 patients (Sjo et al. 2008b). One third of patients had a relapse or progression of disease after initial therapy and relapses were frequently found at extra-ocular sites. Overall survival, however, was not significantly poorer for patients

  8. Evolution of the Marginal Ice Zone: Adaptive Sampling with Autonomous Gliders

    Science.gov (United States)

    2015-09-30

    Gobat Applied Physics Laboratory, University of Washington 1013 NE 40th St. Seattle, WA 98105-6698 phone: (206) 685-7656 fax: (206) 543-6785 email...navigation signals be unavailable) and incorporate enhanced autonomy to perform functions such as sensing overhead ice, determining when to attempt...Marginal Ice Zone (MIZ) Program: Science and Experiment Plan, Technical Report APL-UW 1201. Applied Physics Laboratory, University of Washington

  9. Observation of a fast ozone loss in the marginal ice zone of the Arctic Ocean

    OpenAIRE

    Jacobi, Hans-Werner; L. Kaleschke; Richter, A.; Rozanov, A.; Burrows, J. P.

    2006-01-01

    In both polar regions tropospheric ozone regularly decreases during springtime to negligible concentrations in the atmospheric boundary layer. Here we report the observation of a dramatic ozone depletion event in the atmospheric boundary layer in the vicinity of frost flower fields in the marginal ice zone of the Arctic Ocean monitored by instrumentation on board of the icebreaker RV Polarstern. The ozone mixing ratio decreased from approximately 40 to below 1 ppbV in less than 7 hours. The a...

  10. Wave Climate and Wave Mixing in the Marginal Ice Zones of Arctic Seas, Observations and Modelling

    Science.gov (United States)

    2015-09-30

    PROJECTS Section). With the group of Rogers, observation/modeling study of an energetic wave event in the Arctic marginal zone was conducted ...floe. (right) Surface elevation in the lee of a 5 mm thick polypropylene floe (thick black curves) and incident wave (grey), normalised with respect...Toffoli, A., Marusic, I., Klewicki, J., Hutchins, N., Suslov, S., Walker, D., Chung, D., “A Thermally Stratified Sea-Ice-Wave Interaction Facility”, ARC

  11. An Observational and Analytical Study of Marginal Ice Zone Atmospheric Jets

    Science.gov (United States)

    2016-12-01

    creates more waves in the arctic. These waves prevent flat ice sheets such as nilas from forming and instead cause the formation of pancake ice . Pancake...warmer water to the surface and further contribute to sea ice melt . These conclusions are important to an organization like the US Navy who looks to...AND ANALYTICAL STUDY OF MARGINAL ICE ZONE ATMOSPHERIC JETS by David M. Price December 2016 Thesis Advisor: Peter Guest Second Reader

  12. Primary malignant lymphoma of the parotid gland

    Directory of Open Access Journals (Sweden)

    Sudha H Metikurke

    2012-01-01

    Full Text Available Lymphoma of the salivary gland accounts for 5% of cases of extranodal lymphoma and 10% of malignant salivary gland tumors. Most primary salivary gland lymphomas are B marginal zone lymphomas arising on a background of sialadenitis associated with an autoimmune disorder such as Sjorgen′s syndrome. This report describes a case of primary B-cell lymphoma arising in the parotid gland in a middle-aged female, which was not associated with an autoimmune disorder. Immunohistochemistry studies confirmed the clonal B-cell nature of the tumor. This case highlights the fact that B-cell lymphoma in the salivary gland can go unrecognized due to its non-specific symptoms and requires immunohistochemistry studies for confirmation. We present this case for its rarity.

  13. Autonomous Observations of the Upper Ocean Stratification and Velocity Field about the Seasonality Retreating Marginal Ice Zone

    Science.gov (United States)

    2016-12-30

    boundary layer evolution through summer, highl ighting in particular the role of melt pond drainage on the upper ocean stratification and ice -ocean...stratification and velocity field about the seasonality-retreating marginal ice zone 5b. GRANT NUMBER N00014-12-1-0140 Sc. PROGRAM ELEMENT NUMBER 6...STATEMENT UNLIMITED - UNCLASSIFIED 13. SUPPLEMENTARY NOTES 14. ABSTRACT As a contribution to the Marginal Ice Zone ORI, this research element was

  14. Autonomous Observations of the Upper Ocean Stratification and Velocity Field about the Seasonally-Retreating Marginal Ice Zone

    Science.gov (United States)

    2016-12-30

    summer, highlighting in particular the role of melt pond drainage on the upper ocean stratification and ice -ocean interaction, Figure 7 (Gallaher et al...stratification and velocity field about the seasonality-retreating marginal ice zone Sb. GRANT NUMBER N00014-12-1 -0140 Sc. PROGRAM ELEMENT NUMBER 6...STATEMENT UNLIMITED- UNCLASSIFIED 13. SUPPLEMENTARY NOTES 14. ABSTRACT As a contribution to the Marginal Ice Zone DRI , this research element was

  15. RNA-binding protein VICKZ is expressed in a germinal center associated pattern among lymphoma subtypes

    DEFF Research Database (Denmark)

    Natkunam, Y.; Vainer, G.; Zhao, S.C.;

    2005-01-01

    to the cytoplasm. Among 868 non-Hodgkin and Hodgkin lymphomas tested by immunohistochemistry on tissue microarrays, staining for VICKZ protein was present in 76% (126/165) of follicular lymphoma, 78% (155/200) of DLBCL, 90% (9/10) of mediastinal large B-cell lymphoma, and 100% (2/2) of Burkitt lymphoma. A subset...... of mantle cell lymphoma (11%, 2/19), extranodal (8%, 2/25), and nodal (20%, 1/5) marginal zone lymphoma and lymphoblastic lymphoma (25%, 4/13), showed VICKZ staining. The majority of lymphocyte predominant Hodgkin (92%, 12/13) and classical Hodgkin (94%, 101/108) lymphoma were found to be positive. Among T......Recent effort in the molecular characterization of diffuse large B-cell lymphoma (DLBCL) has led to the recognition that patients with DLBCL of germinal center origin exhibit a better overall survival. Thus, identification and characterization of markers of germinal center derivation...

  16. High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma

    Science.gov (United States)

    2010-08-05

    Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With T(15;17)(q22;q12); Adult Acute Myeloid Leukemia With T(16;16)(p13;q22); Adult Acute Myeloid Leukemia With T(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Acute Promyelocytic Leukemia (M3); Adult Erythroleukemia (M6a); Adult Nasal Type Extranodal NK/T-cell Lymphoma; Adult Pure Erythroid Leukemia (M6b); Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Burkitt Lymphoma; Childhood Acute Erythroleukemia (M6); Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Megakaryocytic Leukemia (M7); Childhood Acute Monoblastic Leukemia (M5a); Childhood Acute Monocytic Leukemia (M5b); Childhood Acute Myeloblastic Leukemia With Maturation (M2); Childhood Acute Myeloblastic Leukemia Without Maturation (M1); Childhood Acute Myeloid Leukemia in Remission; Childhood Acute Myelomonocytic Leukemia (M4); Childhood Acute Promyelocytic Leukemia (M3); Childhood Chronic Myelogenous Leukemia; Childhood Myelodysplastic Syndromes; Chronic Phase Chronic Myelogenous Leukemia; Cutaneous B-cell Non-Hodgkin Lymphoma; De Novo Myelodysplastic Syndromes; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-Cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent

  17. Clinicopathological profile of gastrointestinal lymphomas in Kashmir

    Directory of Open Access Journals (Sweden)

    Mehnaaz Sultan Khuroo

    2016-01-01

    Full Text Available Background: The histological categorization of lymphoma has been a source of controversy for many years for both clinicians and pathologists. Clinicopathologic information of gastrointestinal lymphomas in Indian subcontinent is lacking. We studied histopathological spectrum of Primary Gastrointestinal Lymphomas (PGIL and attempted to classify the G.I. lymphomas based on the recent WHO classification in to major histological types and immunological categories. Material and Methods: This study was done to evaluate the clinicopathological pattern of 100 cases with a histopathological diagnosis of primary gastrointestinal lymphoma at a tertiary care hospital. All patients of primary gastrointestinal lymphomas were included with the help of medical records over a 11-years period that is, January 2005 to December 2015. Results: The study included 100 cases (60 males, 40 females; mean age 51.43 years; age range 4.5-90 years . The disease involved stomach in 82 (82%, small intestine in 8 (8%, large bowel and rectum in 8 (8%, gall bladder in 1 (1% and oesophagus in 1 (1%. 82 (82% of the 100 cases were Diffuse Large B cell lymphomas; 12 (12% were Extra Nodal Marginal Zone Lymphomas (ENMZL of MALT type 2 (2% IPSID 2 (2% of Mantle cell lymphoma morphology, 1 (1% Burkitt's and 1(1% enteropathy associated T cell lymphoma. The commonest presenting symptom was abdominal pain. 99 (99% of 100 tumours were classified as B-cell lymphomas immunohistochemically and majority exhibited monoclonal light chain restriction on kappa/lambda staining. In addition; Burkitt's lymphoma showed positivity for CD 10. One tumour (1% showed positivity for T-cell markers. The data demonstrated that primary GI NHL is more common among males, mainly in their fifth decade. Abdominal pain is the most common presenting symptom, with stomach being the most commonly involved site. Diffuse large cell lymphoma is the most frequent histologic subtype, followed by extranodal marginal-zone B

  18. Canine small clear cell/T-zone lymphoma: clinical presentation and outcome in a retrospective case series.

    Science.gov (United States)

    Martini, V; Marconato, L; Poggi, A; Riondato, F; Aresu, L; Cozzi, M; Comazzi, S

    2016-08-01

    Published studies, taken together, suggest the existence of a single canine lymphoma entity, with a small clear cell appearance by cytological evaluation, a histopathological T-zone pattern and an aberrant CD45-negative T-cell phenotype, mostly characterized by long-term survival. We describe clinical presentation and outcome in a retrospective case series of canine small clear cell/T-zone lymphoma. Despite the reported predisposition of Golden retriever, this breed was not represented in our case series. Most dogs presented with stage V disease, whereas only few had clinical signs or peripheral cytopenias. Blood was almost always more infiltrated than bone marrow. Median survival confirmed the favourable prognosis described in literature, but a few dogs died within a short time. Also, a subgroup of dogs developed second malignancies, eventually leading to death. We did not investigate possible prognostic factors because of the wide variety in treatments, and further studies are needed to identify high-risk animals.

  19. Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21.

    Science.gov (United States)

    Prokopec, Kajsa E; Georgoudaki, Anna-Maria; Sohn, Silke; Wermeling, Fredrik; Grönlund, Hans; Lindh, Emma; Carroll, Michael C; Karlsson, Mikael C I

    2016-09-15

    Marginal zone macrophages (MZM) are strategically located in the spleen, lining the marginal sinus where they sense inflammation and capture Ag from the circulation. One of the receptors expressed by MZM is scavenger receptor macrophage receptor with collagenous structure (MARCO), which has affinity for modified self-antigens. In this article, we show that engagement of MARCO on murine macrophages induces extracellular ATP and loss of CD21 and CD62L on marginal zone B cells. Engagement of MARCO also leads to reduction of Ag transport by marginal zone B cells and affects the subsequent immune response. This study highlights a novel function for MZM in regulating Ag transport and activation, and we suggest that MARCO-dependent ATP release regulates this through shedding of CD21 and CD62L. Because systemic lupus erythematosus patients were shown to acquire autoantibodies against MARCO, this highlights a mechanism that could affect a patient's ability to combat infections.

  20. Meso- and submesoscale structures in marginal ice zone in Arctic ocean using Sentinel-1 data

    Science.gov (United States)

    Tarasenko, Anastasiia

    2016-07-01

    A marginal sea ice zone is a region where ocean currents interact with the sea ice. Recently freezed small sea ice particles (frazil) can be used as a passive tracer for the ocean surface dynamics studies. Sentinel-1 SAR images with a high spatial resolution (40 or 25 m) permit to exploit this approach of "frazil as surface current's passive tracer". A preliminary research on meso- and submesoscale structures in marginal sea ice zone was carried out using Sentinel-1 SAR data. A new dataset of mesoscale structures was created for Eastern Greenland, Barents and Kara seas for 2014-2015. The raw data was processed with SNAP (Sentinel application Platform designed by ESA). A classical method of maximum cross-correlation was tested together with a method developed based on (Kudriavtsev et al, 2014) for eddy-like structures detection. References: Kudryavtsev, Vladimir, I. Kozlov, Bertrand Chapron, and J. A. Johannessen. "Quad-polarization SAR features of ocean currents." Journal of Geophysical Research: Oceans 119, no. 9 (2014): 6046-6065.

  1. Gpr97 is essential for the follicular versus marginal zone B-lymphocyte fate decision.

    Science.gov (United States)

    Wang, J-J; Zhang, L-L; Zhang, Hong-x; Shen, C-L; Lu, S-y; Kuang, Y; Wan, Y-h; Wang, W-g; Yan, H-m; Dang, S-y; Fei, J; Jin, X-l; Wang, Z-g

    2013-10-10

    Gpr97 is an orphan adhesion GPCR and is highly conserved among species. Up to now, its physiological function remains largely unknown. Here, we show that Gpr97 deficiency results in an extensive reduction in B220(+) lymphocytes in mice. More intensive analyses reveal an expanded marginal zone but a decreased follicular B-cell population in Gpr97(-/-)spleen, which displays disorganized architecture characterized by diffuse, irregular B-cell areas and the absence of discrete perifollicular marginal and mantle zones. In vivo functional studies reveal that the mutant mice could generate antibody responses to T cell-dependent and independent antigens, albeit enhanced response to the former and weakened response to the latter. By screening for the molecular events involved in the observed phenotypes, we found that lambda 5 expression is downregulated and its upstream inhibitor Aiolos is increased in the spleen of mutant mice, accompanied by significantly enhanced phosphorylation and nuclear translocation of cAMP response element-binding protein. Interestingly, increased constitutive Nf-κb p50/p65 expression and activity were observed in Gpr97(-/-) spleen, implicating a crucial role of Gpr97 in regulating Nf-κb activity. These findings uncover a novel biological function of Gpr97 in regulating B-cell development, implying Gpr97 as a potential therapeutic target for treatment of immunological disorders.

  2. Deformation and seismicity associated with continental rift zones propagating toward continental margins

    Science.gov (United States)

    Lyakhovsky, V.; Segev, A.; Schattner, U.; Weinberger, R.

    2012-01-01

    We study the propagation of a continental rift and its interaction with a continental margin utilizing a 3-D lithospheric model with a seismogenic crust governed by a damage rheology. A long-standing problem in rift-mechanics, known as thetectonic force paradox, is that the magnitude of the tectonic forces required for rifting are not large enough in the absence of basaltic magmatism. Our modeling results demonstrate that under moderate rift-driving tectonic forces the rift propagation is feasible even in the absence of magmatism. This is due to gradual weakening and "long-term memory" of fractured rocks that lead to a significantly lower yielding stress than that of the surrounding intact rocks. We show that the style, rate and the associated seismicity pattern of the rift zone formation in the continental lithosphere depend not only on the applied tectonic forces, but also on the rate of healing. Accounting for the memory effect provides a feasible solution for thetectonic force paradox. Our modeling results also demonstrate how the lithosphere structure affects the geometry of the propagating rift system toward a continental margin. Thinning of the crystalline crust leads to a decrease in the propagation rate and possibly to rift termination across the margin. In such a case, a new fault system is created perpendicular to the direction of the rift propagation. These results reveal that the local lithosphere structure is one of the key factors controlling the geometry of the evolving rift system and seismicity pattern.

  3. The pleural sandwich sign in two cases of primary pleural lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yoo Kyung; Lee, Myung Jae; Ryu, Yon Ju; Cho, Min Sun [School of Medicine, Ewha Womans University, Seoul (Korea, Republic of)

    2015-02-15

    The sandwich sign is used to describe mesenteric lymphoma in which mesenteric vessels and fat are enveloped by enlarged mesenteric lymph nodes. We present two cases of primary pleural lymphoma demonstrating the 'pleural sandwich sign'. Contrast-enhanced computed tomography showed conglomerated parietal pleural and extrapleural masses encasing the intercostal arteries. Histopathological examinations confirmed low grade marginal zone B-cell lymphoma in an 80-year-old man and diffuse large B-cell lymphoma in a 68-year-old man. The pleural sandwich sign may suggest the diagnosis of primary pleural lymphoma.

  4. Primary thymic extranodal marginal zone B cell lymphoma as an incidental finding in a Caucasian woman

    DEFF Research Database (Denmark)

    Krogh Petersen, Jeanette; Larsen, Thomas Stauffer; Møller, Michael Boe

    2015-01-01

    of muscle and joint pain. An anterior mediastinal mass was detected by a positron emission tomography-CT (PET-CT) scan and thymectomy was performed. The mass was contained within the thymus with a homogeneous pale cut surface with solid areas. Histologically, the typical morphological and immunophenotypic...... features of TML were found, with a prominent lymphoid infiltrate comprising of small-to-medium-sized neoplastic lymphocytes, plasmacytic differentiation and a distorted thymic epithelial network. Postoperative follow-up has indicated an associated undifferentiated connective tissue disease (UCTD...

  5. Extranodal marginal zone lymphoma in the ocular region: clinical, immunophenotypical, and cytogenetical characteristics

    DEFF Research Database (Denmark)

    Sjö, Lene D; Heegaard, Steffen; Prause, Jan U;

    2008-01-01

    the period 1980 to 2005 were reviewed and reclassified according to the World Health Organization (WHO) classification. Cases reclassified as EMZL were selected and reviewed with respect to clinical characteristics and outcome. The presence of translocations involving IGH and/or MALT1 was investigated in 42...... were frequently found at extraocular sites. Five-year progression-free survival and overall survival (OS) rates were 71% and 75%, respectively. Translocations involving the IGH- or MALT1-gene loci were detected in 2 (5%) of 42 specimens. In Cox regression multivariate analysis, IGH...

  6. Reappraisal of Benign Lymphoepithelial Sialadenitis for Evidence of Extranodal Marginal Zone B-Cell Lymphoma

    Science.gov (United States)

    2016-09-28

    chromosome 18 via FISH. No cases revealed translocations involving the MALT1 gene. Epitheliotropic B cells exhibited a CD20, CD79a and PAX 5 positive B-cell...tissue as described by Reed et al. (1993): Two 7-8 µm paraffin sections from each block were deparaffinized in xylene, rehydrated with ethanol, and...amplification products of the first cycles (so-called outer nest) are not amplified in the second cycles (inner nest) ( Reed et al. 1993). Table 6

  7. Melt ponds and marginal ice zone from new algorithm of sea ice concentration retrieval

    Science.gov (United States)

    Repina, Irina; Tikhonov, Vasiliy; Komarova, Nataliia; Raev, Mikhail; Sharkov, Evgeniy

    2016-04-01

    Studies of spatial and temporal properties of sea ice distribution in polar regions help to monitor global environmental changes and reveal their natural and anthropogenic factors, as well as make forecasts of weather, marine transportation and fishing conditions, assess perspectives of mineral mining on the continental shelf, etc. Contact methods of observation are often insufficient to meet the goals, very complicated technically and organizationally and not always safe for people involved. Remote sensing techniques are believed to be the best alternative. Its include monitoring of polar regions by means of passive microwave sensing with the aim to determine spatial distribution, types, thickness and snow cover of ice. However, the algorithms employed today to retrieve sea ice characteristics from passive microwave sensing data for different reasons give significant errors, especially in summer period and also near ice edges and in cases of open ice. A new algorithm of sea ice concentration retrieval in polar regions from satellite microwave radiometry data is discussed. Beside estimating sea ice concentration, the algorithm makes it possible to indicate ice areas with melting snow and melt ponds. Melt ponds are an important element of the Arctic climate system. Covering up to 50% of the surface of drifting ice in summer, they are characterized by low albedo values and absorb several times more incident shortwave radiation than the rest of the snow and ice cover. The change of melt ponds area in summer period 1987-2015 is investigated. The marginal ice zone (MIZ) is defined as the area where open ocean processes, including specifically ocean waves, alter significantly the dynamical properties of the sea ice cover. Ocean wave fields comprise short waves generated locally and swell propagating from the large ocean basins. Depending on factors like wind direction and ocean currents, it may consist of anything from isolated, small and large ice floes drifting over a

  8. The р53 expression in cells of marginal zone of duodenal ulcers during acute bleeding

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    Sulayeva O.N.

    2009-01-01

    Full Text Available The aim of the work was to estimate the intensity and tissue distribution of proapoptogen p53 expression in duodenal mucosa in patients with acute bleeding caused by peptic ulcers. In 31 patients (1st group the healing of ulcer was detected after effective endoscopic hemostasis and in 15 patients rebleeding took place (2nd group. Performed immunocytochemical investigation allow to determine that acute ulcer bleeding was associated with activation of marginal zone cells apoptosis which was maximal in covering epithelium, vascular endothelium and regions infiltrated by lymphocytes. In patients with rebleeding the higher values of р53 expression were detected in crypts epithelium and in endothelium of dilatating vessels accompanied with intensive edema and lymphocytes infiltration of lamina propria and muscularis mucosae with perifocal activation of cells death. Additionally to apoptosis in 2nd group duodenum the necrosis of cells and epithelium desquamation were found, reflecting the tissue disintegration of duodenal mucosa.

  9. Wave observation in the marginal ice zone with the TerraSAR-X satellite

    Science.gov (United States)

    Gebhardt, Claus; Bidlot, Jean-Raymond; Gemmrich, Johannes; Lehner, Susanne; Pleskachevsky, Andrey; Rosenthal, Wolfgang

    2016-07-01

    This article investigates the penetration of ocean waves into the marginal ice zone (MIZ), observed by satellite, and likewise provides a basis for the future cross-validation of respective models. To this end, synthetic aperture radar images from the TerraSAR-X satellite (TS-X) and numerical simulations of the European Centre for Medium-Range Weather Forecasts (ECMWF) are used. The focus is an event of swell waves, developed during a storm passage in the Atlantic, penetrating deeply into the MIZ off the coast of Eastern Greenland in February 2013. The TS-X scene which is the basis for this investigation extends from the ice-free open ocean to solid ice. The variation of the peak wavelength is analysed and potential sources of variability are discussed. We find an increase in wavelength which is consistent with the spatial dispersion of deep water waves, even within the ice-covered region.

  10. Massive barite deposits in the convergent margin off Peru: Implications for fluid circulation within subduction zones

    Science.gov (United States)

    Aquilina, L.; Dia, A. N.; Boulègue, J.; Bourgois, J.; Fouillac, A. M.

    1997-03-01

    The convergent margin of Peru, characterized by an extensional tectonic regime and the lack of a well-developed accretionary prism, has been investigated by a deep-sea submersible during the Nautiperc cruise (March-April, 1991). This allowed the collection of fluid samples, soft sediments, and barite concretions in the vicinity of biological communities associated with fluid steps. Major and trace element contents as well as strontium, oxygen, hydrogen, and sulfur isotopic compositions have been measured on fluid and/or solid samples to constrain the nature and origin of fluid circulating in this extensional tectonic context. Chemical variations with respect to bottom seawater composition have been recorded in the fluid samples and suggest the presence of a nonlocal component in the fluid expelled at the seafloor. The major variations correspond to elevations of the Cl, Na, and the Ba contents as well as the 87Sr /86Sr ratios. This is interpreted as the expulsion of a radiogenic, continent-related (basinal brine and/or meteoric water) fluid. Massive barite concretions have been collected at the seafloor in two areas of major fluid venting. The radiogenic signature (strontium isotopic composition) of the barite concretions implies that they are related to the nonlocal deep fluid component identified in the fluid samples. Furthermore, it is shown that these barite deposits testify to a hot, short, and intensive fluid circulation event. Compared to subduction zones that exhibit venting fluid with a strong oceanic water signature, the nature and origin of venting fluid along the subduction zone of Peru are different. The extensional tectonic regime of the Peru continental margin, locally associated with a dense E-W trending fault network, is an agent which may help to drain continent-related fluid as deep as the subduction scarp at the trench-slope boundary.

  11. The Floe Size Distribution in the Marginal Ice Zone of the Beaufort and Chukchi Seas

    Science.gov (United States)

    Schweiger, A. J. B.; Stern, H. L., III; Stark, M.; Zhang, J.; Steele, M.; Hwang, P. B.

    2014-12-01

    Several key processes in the Marginal Ice Zone (MIZ) of the Arctic Ocean are related to the size of the ice floes, whose diameters range from meters to tens of kilometers. The floe size distribution (FSD) influences the mechanical properties of the ice cover, air-sea momentum and heat transfer, lateral melting, and light penetration. However, no existing sea-ice/ocean models currently simulate the FSD in the MIZ. Model development depends on observations of the FSD for parameterization, calibration, and validation. To support the development and implementation of the FSD in the Marginal Ice Zone Modeling and Assimilation System (MIZMAS), we have analyzed the FSD in the Beaufort and Chukchi seas using multiple sources of satellite imagery: NASA's Moderate Resolution Imaging Spectroradiometer (MODIS) on the Terra and Aqua satellites (250 m pixel size), the USGS Landsat 8 satellite (80 m pixel size), the Canadian Space Agency's synthetic aperture radar (SAR) on RADARSAT (50 meter pixel size), and declassified National Technical Means imagery from the Global Fiducials Library (GFL) of the USGS (1 m pixel size). The procedure for identifying ice floes in the imagery begins with manually delineating cloud-free regions (if necessary). A threshold is then chosen to separate ice from water. Morphological operations and other semi-automated techniques are used to identify individual floes, whose properties are then easily calculated. We use the mean caliper diameter as the measure of floe size. The FSD is adequately described by a power-law in which the exponent characterizes the relative number of large and small floes. Changes in the exponent over time and space reflect changes in physical processes in the MIZ, such as sea-ice deformation, fracturing, and melting. We report results of FSD analysis for the spring and summer of 2013 and 2014, and show how the FSD will be incorporated into the MIZMAS model.

  12. Upper Ocean Evolution Across the Beaufort Sea Marginal Ice Zone from Autonomous Gliders

    Science.gov (United States)

    Lee, Craig; Rainville, Luc; Perry, Mary Jane

    2016-04-01

    The observed reduction of Arctic summertime sea ice extent and expansion of the marginal ice zone (MIZ) have profound impacts on the balance of processes controlling sea ice evolution, including the introduction of several positive feedback mechanisms that may act to accelerate melting. Examples of such feedbacks include increased upper ocean warming though absorption of solar radiation, elevated internal wave energy and mixing that may entrain heat stored in subsurface watermasses (e.g., the relatively warm Pacific Summer (PSW) and Atlantic (AW) waters), and elevated surface wave energy that acts to deform and fracture sea ice. Spatial and temporal variability in ice properties and open water fraction impact these processes. To investigate how upper ocean structure varies with changing ice cover, and how the balance of processes shift as a function of ice fraction and distance from open water, four long-endurance autonomous Seagliders occupied sections that extended from open water, through the marginal ice zone, deep into the pack during summer 2014 in the Beaufort Sea. Sections reveal strong fronts where cold, ice-covered waters meet waters that have been exposed to solar warming, and O(10 km) scale eddies near the ice edge. In the pack, Pacific Summer Water and a deep chlorophyll maximum form distinct layers at roughly 60 m and 80 m, respectively, which become increasingly diffuse as they progress through the MIZ and into open water. The isopynal layer between 1023 and 1024 kgm-3, just above the PSW, consistently thickens near the ice edge, likely due to mixing or energetic vertical exchange associated with strong lateral gradients in this region. This presentation will discuss the upper ocean variability, its relationship to sea ice extent, and evolution over the summer to the start of freeze up.

  13. Seroprevalence and sociocultural conditionants of Chagas disease in school aged children of marginal zones of Asunción

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    Vera Ninfa I.

    1998-01-01

    Full Text Available Chagas disease is becoming a public health problem in Latin America due to the wide distribution, the high prevalence, the magnitude of the damage caused and the difficulties to control it. In Paraguay, the disease is mainly distributed in the departments of Paraguari, Cordillera and Central. Prevalence in marginal zones, where migrations from rural populations and endemic areas make possible the urbanization of the disease, has no been studied yet. This is a descriptive study with a cross-sectional sampling and a probabilistic system recruitment carried out in school aged children from marginal zones of Asuncion to determine the prevalence of Chagas' disease. Serological methods, parasite isolation and questionnaires were used to achieve the goals. Nine hundred and fifty three children were studied to determine the prevalence of Chagas' disease in marginal zones which was 1.4%.

  14. Evaluation of CD45 protein expression and transcript in canine small clear cell/T zone lymphoma.

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    Marzia Cozzi

    2015-07-01

    Full Text Available Canine small clear cell lymphoma is a peculiar lymphoma entity with T-zone histopathological pattern andindolent clinical course. From an immunophenotypic point of view the main feature is the lack of CD45 staining by flow-cytometry (FC, which accounts for >95% of cases. Underlying mechanisms have never been investigated.Aim of this work was to evaluate CD45 protein and mRNA expression in small clear cell lymphoma.Lymph nodes of 18 cases and 11 controls, with either reactive hyperplasia or CD45-positive high grade T-cell lymphoma, were investigated. FC was performed on lymph node fine needle aspiration and CD45 median fluorescence intensity (MFI was then evaluated on small clear cells and normal residual T-lymphocytes. CD45 surface expression was also evaluated by immunohistochemical reaction on paraffin wax-embedded lymph node sections.Quantitative real-time RT-PCR was performed on cases and controls. Total RNA was isolated from cell suspension in RNA later. The generated CD45cDNA was amplified and ΔΔCt method was used for the relative mRNA quantification.CD45-MFI in neoplastic cells was <1% compared to normal residual T-lymphocytes in the same sample. Cells were also negative for CD45 stain on histopathological preparations. RT-PCR showed a significantly lower amount of CD45 transcript in neoplastic samples compared to controls, likely due to the residual population.Results showed the lack of CD45 surface antigen and the virtually absence of CD45-mRNA in small clear cell lymphoma. We hypothesize a possible genomic/epigenomic aberration; further studies are in progress to investigate the pathogenesis of this aberrancy and the possible linkage to lymphomagenesis.

  15. Shallow methylmercury production in the marginal sea ice zone of the central Arctic Ocean.

    Science.gov (United States)

    Heimbürger, Lars-Eric; Sonke, Jeroen E; Cossa, Daniel; Point, David; Lagane, Christelle; Laffont, Laure; Galfond, Benjamin T; Nicolaus, Marcel; Rabe, Benjamin; van der Loeff, Michiel Rutgers

    2015-05-20

    Methylmercury (MeHg) is a neurotoxic compound that threatens wildlife and human health across the Arctic region. Though much is known about the source and dynamics of its inorganic mercury (Hg) precursor, the exact origin of the high MeHg concentrations in Arctic biota remains uncertain. Arctic coastal sediments, coastal marine waters and surface snow are known sites for MeHg production. Observations on marine Hg dynamics, however, have been restricted to the Canadian Archipelago and the Beaufort Sea (Arctic Ocean (79-90 °N) profiles for total mercury (tHg) and MeHg. We find elevated tHg and MeHg concentrations in the marginal sea ice zone (81-85 °N). Similar to other open ocean basins, Arctic MeHg concentration maxima also occur in the pycnocline waters, but at much shallower depths (150-200 m). The shallow MeHg maxima just below the productive surface layer possibly result in enhanced biological uptake at the base of the Arctic marine food web and may explain the elevated MeHg concentrations in Arctic biota. We suggest that Arctic warming, through thinning sea ice, extension of the seasonal sea ice zone, intensified surface ocean stratification and shifts in plankton ecodynamics, will likely lead to higher marine MeHg production.

  16. Therapy of gastric mucosa associated lymphoid tissue lymphoma

    Institute of Scientific and Technical Information of China (English)

    Andrea Morgner; Renate Schmelz; Christian Thiede; Manfred Stolte; Stephan Miehlke

    2007-01-01

    Gastric mucosa associated lymphoid tissue (MALT)lymphoma has recently been incorporated into the World Health Organization (WHO) lymphoma classification,termed as extranodal marginal zone B-cell lymphoma of MALT-type. In about 90% of cases this lymphoma is associated with H pylori infection which has been clearly shown to play a causative role in lymphomagenesis.Although much knowledge has been gained in defining the clinical features, natural history, pathology, and molecular genetics of the disease in the last decade, the optimal treatment approach for gastric MALT lymphomas,especially locally advanced cases, is still evolving. In this review we focus on data for the therapeutic, stage dependent management of gastric MALT lymphoma.Hence, the role of eradication therapy, surgery,chemotherapy and radiotherapy is critically analyzed.Based on these data, we suggest a therapeutic algorithm that might help to better stratify patients for optimal treatment success.

  17. Effects of electroacupuncture on astrocytes in the marginal zone of focal cerebral ischemia in rats

    Institute of Scientific and Technical Information of China (English)

    Yan Luo; Nenggui Xu; Wei Yi; Yong Zi; Yixu Du

    2009-01-01

    BACKGROUND: Astrocytes react sensitively to cerebral ischemia, causing reactive proliferation and activation, which may contribute to their effect in protecting or injuring neuronal regeneration. Whether acupuncture, as a treatment for cerebral ischemia, regulates the activated state of astrocytes has become a focus of recent investigations.OBJECTIVE: To observe the effects of electroacupuncture (EA) on ultrastructure changes and reactive proliferation of astrocytes in the marginal zone of focal cerebral ischemia in rats. DESIGN, TIME AND SETTING: Randomized, controlled animal study. This study was performed at the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine between December 2007 and July 2008.MATERIALS: A total of 90 male Wistar rats were randomly divided into sham operated, model and EA groups. Each group was subdivided into 1 hour, 1, 3, 7, and 21 days post-cerebral ischemia groups, with six animals for each time point. Rabbit anti-rat glial fibrillary acidic protein (GFAP) and goat anti-rabbit IgG/tetramethylrhodamine isothiocyanate were provided by Beijing Biosynthesis Biotechnology. The G-6805 electric acupuncture apparatus was provided by Shanghai Huayi.METHODS: Heat-coagulation-induced occlusion of the middle cerebral artery was performed to establish a model of focal cerebral ischemia, in the model and EA groups. Middle cerebral arteries were exposed without occlusion in sham operated group. EA was applied immediately after surgery in the EA group, 4/20 Hz, 2.0-3.0 V, 1-3 mA, to Baihui (GV 20) and Dazhui (GV 14), for 30 minutes. The treatment was performed once a day. The sham operated and model groups did not receive acupuncture.MAIN OUTCOME MEASURES: In the marginal zone of focal cerebral ischemia in rats at different time points after intervention, the ultrastructure changes of astrocytes were observed by using transmission electronic microscopy. GFAP expression in astrocytes was also measured by laser confocal

  18. Meaning-Making and Motivation in Urban Zones of Marginalization: Mapping the Ecocultural Context of Educational Goals

    Science.gov (United States)

    Eksner, H. Julia

    2015-01-01

    This article explores how achievement motivation is framed by the larger context of the devaluation of educational capital that is currently underway in urban centers in Europe. The article elucidates the shared cultural meaning working-class German Turkish youths living in urban marginalized zones in Berlin, Germany create about the decreasing…

  19. Molecular Pathogenesis of MALT Lymphoma

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    Katharina Troppan

    2015-01-01

    Full Text Available Approximately 8% of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT, also known as MALT lymphoma, which was first described in 1983 by Isaacson and Wright. MALT lymphomas arise at a wide range of different extranodal sites, with the highest frequency in the stomach, followed by lung, ocular adnexa, and thyroid, and with a low percentage in the small intestine. Interestingly, at least 3 different, apparently site-specific, chromosomal translocations and missense and frameshift mutations, all pathway-related genes affecting the NF-κB signal, have been implicated in the development and progression of MALT lymphoma. However, these genetic abnormalities alone are not sufficient for malignant transformation. There is now increasing evidence suggesting that the oncogenic product of translocation cooperates with immunological stimulation in oncogenesis, that is, the association with chronic bacterial infection or autoaggressive process. This review mainly discusses MALT lymphomas in terms of their genetic aberration and association with chronic infections and summarizes recent advances in their molecular pathogenesis.

  20. Selected physical, biological and biogeochemical implications of a rapidly changing Arctic Marginal Ice Zone

    Science.gov (United States)

    Barber, David G.; Hop, Haakon; Mundy, Christopher J.; Else, Brent; Dmitrenko, Igor A.; Tremblay, Jean-Eric; Ehn, Jens K.; Assmy, Philipp; Daase, Malin; Candlish, Lauren M.; Rysgaard, Søren

    2015-12-01

    The Marginal Ice Zone (MIZ) of the Arctic Ocean is changing rapidly due to a warming Arctic climate with commensurate reductions in sea ice extent and thickness. This Pan-Arctic review summarizes the main changes in the Arctic ocean-sea ice-atmosphere (OSA) interface, with implications for primary- and secondary producers in the ice and the underlying water column. Changes in the Arctic MIZ were interpreted for the period 1979-2010, based on best-fit regressions for each month. Trends of increasingly open water were statistically significant for each month, with quadratic fit for August-November, illustrating particularly strong seasonal feedbacks in sea-ice formation and decay. Geographic interpretations of physical and biological changes were based on comparison of regions with significant changes in sea ice: (1) The Pacific Sector of the Arctic Ocean including the Canada Basin and the Beaufort, Chukchi and East Siberian seas; (2) The Canadian Arctic Archipelago; (3) Baffin Bay and Hudson Bay; and (4) the Barents and Kara seas. Changes in ice conditions in the Barents sea/Kara sea region appear to be primarily forced by ocean heat fluxes during winter, whereas changes in the other sectors appear to be more summer-autumn related and primarily atmospherically forced. Effects of seasonal and regional changes in OSA-system with regard to increased open water were summarized for photosynthetically available radiation, nutrient delivery to the euphotic zone, primary production of ice algae and phytoplankton, ice-associated fauna and zooplankton, and gas exchange of CO2. Changes in the physical factors varied amongst regions, and showed direct effects on organisms linked to sea ice. Zooplankton species appear to be more flexible and likely able to adapt to variability in the onset of primary production. The major changes identified for the ice-associated ecosystem are with regard to production timing and abundance or biomass of ice flora and fauna, which are related to

  1. HEPATITIS C VIRUS INFECTION AND LYMPHOMA

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    Emmanuel Bachy

    2010-03-01

    Full Text Available Apart from its well known role as an etiological agent for non-A and non-B viral hepatitis, there is growing evidence that hepatitis C virus is associated to B-cell non-Hodgkin lymphoma. The association between HCV and lymphoproliferative disorders has been recently postulated based on epidemiological data, biological studies and clinical observations. Although various subtypes of lymphomas appear to be associated to HCV, diffuse large B-cell lymphoma, small lymphocytic lymphoma/chronic lymphocytic leukemia and marginal zone lymphoma appeared to be particularly represented among HCV-positive patients.  The causative role of HCV in those disorders has been further supported by the response to anti-viral therapy. Despite a better understanding of pathophysiological processes at stake leading from HCV infection to overt lymphoma, many issues still need to be further elucidated. Although HCV has been demonstrated to directly infect peripheral blood mononuclear cells both in vitro and, in some cases, in vivo, a strong body of evidence rather supports the hypothesis of an indirect transformation mechanism by which sustained antigenic stimulation leads from oligoclonal to monoclonal expansion and sometimes to lymphoma, probably through secondary oncogenic events. Here, we review epidemiological and biological studies, as well as clinical data on antiviral therapy, linking HCV-infection to B-cell non-Hodgkin lymphoma.

  2. Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement.

    Science.gov (United States)

    Vora, Kalpit A; Nichols, Elizabeth; Porter, Gene; Cui, Yan; Keohane, Carol Ann; Hajdu, Richard; Hale, Jeffery; Neway, William; Zaller, Dennis; Mandala, Suzanne

    2005-08-01

    FTY720 is an immunosuppressive agent that modulates lymphocyte trafficking. It is phosphorylated in vivo to FTY720-phosphate (FTY-P) and binds to a family of G protein-coupled receptors recognizing sphingosine 1-phosphate (S1P) as the natural ligand. It has previously been reported that FTY-P blocks egress of lymphocytes from the thymus and lymph nodes, resulting in peripheral blood lymphopenia. We now report that FTY-P also causes displacement of marginal zone (MZ) B cells to the splenic follicles, an effect that is similar to that observed after in vivo administration of lipopolysaccharide. This effect is specific to B cells in the MZ, as treatment with FTY-P does not cause redistribution of the resident macrophage population. A small but statistically significant decrease in the expression of beta1 integrin on MZ B cells was observed with FTY-P treatment. The redistribution of MZ B cells from the MZ sinuses does not abolish the ability of these cells to respond to the T-independent antigen, trinitrophenol-Ficoll. It has been proposed that the displacement of MZ B cells to the follicles is an indication of cell activation. Consistent with this, FTY-P caused an increase in percentage of MZ B cells expressing activation markers CD9, CD1d, and CD24. These results suggest that S1P receptors on MZ B cells are responsible for their mobilization to follicles.

  3. The ciliary margin zone of the mammalian retina generates retinal ganglion cells

    Science.gov (United States)

    Marcucci, Florencia; Murcia-Belmonte, Veronica; Coca, Yaiza; Ferreiro-Galve, Susana; Wang, Qing; Kuwajima, Takaaki; Khalid, Sania; Ross, M. Elizabeth; Herrera, Eloisa; Mason, Carol

    2016-01-01

    Summary The retina of lower vertebrates grows continuously by integrating new neurons generated from progenitors in the ciliary margin zone (CMZ). Whether the mammalian CMZ provides the neural retina with retinal cells is controversial. Live-imaging of embryonic retina expressing eGFP in the CMZ shows that cells migrate laterally from the CMZ to the neural retina where differentiated retinal ganglion cells (RGCs) reside. As Cyclin D2, a cell-cycle regulator, is enriched in ventral CMZ, we analyzed Cyclin D2−/− mice to test whether the CMZ is a source of retinal cells. Neurogenesis is diminished in Cyclin D2 mutants, leading to a reduction of RGCs in the ventral retina. In line with these findings, in the albino retina, the decreased production of ipsilateral RGCs is correlated with fewer Cyclin D2+ cells. Together, these results implicate the mammalian CMZ as a neurogenic site that produces RGCs and whose proper generation depends on Cyclin D2 activity. PMID:28009286

  4. Defective anti-polysaccharide response and splenic marginal zone disorganization in ALPS patients.

    Science.gov (United States)

    Neven, Bénédicte; Bruneau, Julie; Stolzenberg, Marie-Claude; Meyts, Isabelle; Magerus-Chatinet, Aude; Moens, Leen; Lanzarotti, Nina; Weller, Sandra; Amiranoff, Denise; Florkin, Benoit; Bader-Meunier, Brigitte; Leverger, Guy; Ferster, Alice; Chantrain, Christophe; Blanche, Stéphane; Picard, Capucine; Molina, Thierry Jo; Brousse, Nicole; Durandy, Anne; Rizzi, Marta; Bossuyt, Xavier; Fischer, Alain; Rieux-Laucat, Frederic

    2014-09-04

    Autoimmune lymphoproliferative syndrome (ALPS) caused by impaired FAS-mediated apoptosis of lymphocytes is characterized by lymphoproliferation, autoimmunity, but also an increased risk of invasive bacterial infection, notably following splenectomy. We surveyed a cohort of 100 ALPS patients (including 33 splenectomized) and found that 12 (10 splenectomized) had experienced 23 invasive bacterial infections mainly caused by Streptococcus pneumoniae. This vulnerability was associated with evidence of defective B-cell function characterized by low serum immunoglobulin (Ig) M, low IgM antibody production in response to S pneumoniae following nonconjugated immunization, and low blood memory B-cells counts (including marginal zone [MZ] B-cell counts). This immunodeficiency strongly correlated with intensity of lymphoproliferation. Spleen sections from 9 ALPS patients revealed double-negative T-cell (DN-T) infiltration of the MZ, which was depleted of B cells. MZ in ALPS patients contained an abnormally thick layer of MAdCAM-1((+)) stromal cells and an excess of DN-Ts. DN-Ts were shown to express MAdCAM-1 ligand, the α4β7 integrin. These observations suggest that accumulating DN-Ts are trapped within stromal cell meshwork and interfere with correct localization of MZ B cells. Similar observations were made in spleens of fas-deficient mice. Our data revealed an unexpected mechanism by which ALPS results in anti-polysaccharide IgM antibody production-specific defect. Splenectomy should be avoided.

  5. Mapping and Assessing Variability in the Antarctic Marginal Ice Zone, the Pack Ice and Coastal Polynyas

    Science.gov (United States)

    Stroeve, Julienne; Jenouvrier, Stephanie

    2016-04-01

    Sea ice variability within the marginal ice zone (MIZ) and polynyas plays an important role for phytoplankton productivity and krill abundance. Therefore mapping their spatial extent, seasonal and interannual variability is essential for understanding how current and future changes in these biological active regions may impact the Antarctic marine ecosystem. Knowledge of the distribution of different ice types to the total Antarctic sea ice cover may also help to shed light on the factors contributing towards recent expansion of the Antarctic ice cover in some regions and contraction in others. The long-term passive microwave satellite data record provides the longest and most consistent data record for assessing different ice types. However, estimates of the amount of MIZ, consolidated pack ice and polynyas depends strongly on what sea ice algorithm is used. This study uses two popular passive microwave sea ice algorithms, the NASA Team and Bootstrap to evaluate the distribution and variability in the MIZ, the consolidated pack ice and coastal polynyas. Results reveal the NASA Team algorithm has on average twice the MIZ and half the consolidated pack ice area as the Bootstrap algorithm. Polynya area is also larger in the NASA Team algorithm, and the timing of maximum polynya area may differ by as much as 5 months between algorithms. These differences lead to different relationships between sea ice characteristics and biological processes, as illustrated here with the breeding success of an Antarctic seabird.

  6. Morphosedimentary expression of the Giant Pock Mark structure known as the "Gran Burato" (Transitional Zone, Galicia continental margin)

    Science.gov (United States)

    Lopez, Angel Enrique; Rubio, Belén; Rey, Daniel; Mohamed, Kais; Alvarez, Paula; Plaza-Morlote, Maider; Bernabeu, Ana; Druet, Maria; Martins, Virginia

    2016-04-01

    This paper presents the characterization of the sedimentary environment and other sedimentological features of the Transitional Zone of the Galicia continental margin, in the vicinity of the giant pock -mark structure known as the Gran Burato. The area is characterized by marginal platforms and a horst-graben system controlled by NW-SE oriented normal faults. In this zone, three giant pockmark structures, one of them known as the Gran Burato, were reported as associated to large-scale fluid escapes. The study area is located on the Transitional Zone (TZ) of the Galicia passive continental margin, which extends from Cape Finisterre (43o N) in the North to around 40oN in the South. This margin shows a complex structural configuration, which is reflected in the seabed, owing to tectonic movements from Mesozoic rifting phases and Eocene compression (Pyrennean Orogeny). Sedimentological, geochemical and physical properties analysis and 14C AMS-dating of a 4 m piston core extracted in the vicinity of the Gran Burato complemented by multibeam and TOPAS surveys allowed characterizing of the sedimentary environment in the study area. The interpretation of these data showed that the sedimentary and tectonic evolution of the area controlled by the activity of fluid dynamics.

  7. Chimeric antigen receptor T-cell therapies for lymphoma.

    Science.gov (United States)

    Brudno, Jennifer N; Kochenderfer, James N

    2017-08-31

    New therapies are needed for patients with Hodgkin or non-Hodgkin lymphomas that are resistant to standard therapies. Indeed, unresponsiveness to standard chemotherapy and relapse after autologous stem-cell transplantation are indicators of an especially poor prognosis. Chimeric antigen receptor (CAR) T cells are emerging as a novel treatment modality for these patients. Clinical trial data have demonstrated the potent activity of anti-CD19 CAR T cells against multiple subtypes of B-cell lymphoma, including diffuse large-B-cell lymphoma (DLBCL), follicular lymphoma, mantle-cell lymphoma, and marginal-zone lymphoma. Importantly, anti-CD19 CAR T cells have impressive activity against chemotherapy-refractory lymphoma, inducing durable complete remissions lasting >2 years in some patients with refractory DLBCL. CAR-T-cell therapies are, however, associated with potentially fatal toxicities, including cytokine-release syndrome and neurological toxicities. CAR T cells with novel target antigens, including CD20, CD22, and κ-light chain for B-cell lymphomas, and CD30 for Hodgkin and T-cell lymphomas, are currently being investigated in clinical trials. Centrally manufactured CAR T cells are also being tested in industry-sponsored multicentre clinical trials, and will probably soon become a standard therapy. Herein, we review the clinical efficacy and toxicity of CAR-T-cell therapies for lymphoma, and discuss their limitations and future directions with regard to toxicity management, CAR designs and CAR-T-cell phenotypes, conditioning regimens, and combination therapies.

  8. [Research progress on the etiology and pathogenesis of MALT lymphoma].

    Science.gov (United States)

    Wang, Xiao-Can; Ke, Xiao-Yan

    2012-12-01

    Mucosa-associated lymphoid tissue (MALT) lymphoma originated outside the lymph nodes is low grade malignant B cell lymphoma. It is the most frequent type of marginal zone non-Hodgkin's lymphoma, that usually occurs in the stomach, salivary gland, thyroid gland and orbital adnexa. Gastric MALT lymphoma accounts for 50% of MALT lymphoma. Gastric MALT lymphoma has been confirmed to relate with Helicobacter pylori (HP) infection, its main pathogenesis is immune reaction, but some patients with chromosome translocation have no response to HP eradication, suggesting presence of other unknown pathogenesis. The chromosome translocations in MALT lymphoma are t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18)(q32;q21), t(3;14)(p14.1;q32). Recent studies show some new chromosomal abnormalities such as 6q23.3/A20 and so on, which have some effects on clinical course and prognosis. MALT lymphoma with chromosome abnormalities usually activate common NF-κB molecular pathway, and persistent active NF-κB pathway drives tumor cell proliferative and active, resulting in lymphoma incidence. In this article, the advances in the etiology and pathogenesis of MALT lymphoma were reviewed.

  9. T(14;18)(q32;q21) involving MALT1 and IGH genes occurs in extranodal diffuse large B-cell lymphomas of the breast and testis

    NARCIS (Netherlands)

    Kuper-Hommel, M.J.; Schreuder, M.I.; Gemmink, A.H.; Krieken, J.H. van

    2013-01-01

    Primary B-cell lymphoma of the testis, breast and thyroid are rare and data concerning cytogenetic aberrations at these extranodal sites are scarce. We examined the presence of extranodal marginal zone lymphoma-associated translocations, t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18)(q32;q21), t(3;14

  10. The Neotethyan Sanandaj-Sirjan zone of Iran as an archetype for passive margin-arc transitions

    Science.gov (United States)

    Hassanzadeh, Jamshid; Wernicke, Brian P.

    2016-03-01

    The Sanandaj-Sirjan zone of Iran is a northwest trending orogenic belt immediately north of the Zagros suture, which represents the former position of the Neotethys Ocean. The zone contains the most extensive, best preserved record of key events in the formation and evolution of the Neotethys, from its birth in Late Paleozoic time through its demise during the mid-Tertiary collision of Arabia with Eurasia. The record includes rifting of continental fragments off of the northern margin of Gondwanaland, formation of facing passive continental margins, initiation of subduction along the northern margin, and progressive development of a continental magmatic arc. The latter two of these events are critical phases of the Wilson Cycle that, elsewhere in the world, are poorly preserved in the geologic record because of superimposed events. Our new synthesis reaffirms the similarity between this zone and various terranes to the north in Central Iran. Late Paleozoic rifting, preserved as A-type granites and accelerated subsidence, was followed by a phase of pronounced subsidence and shallow marine sedimentation in Permian through Triassic time, marking the formation and evolution of passive margins on both sides of the suture. Subduction and arc magmatism began in latest Triassic/Early Jurassic time, culminating at ~170 Ma. The extinction of arc magmatism in this zone, and its shift northeastward to form the subparallel Urumieh-Dokhtar arc, occurred diachronously along strike, in Late Cretaceous or Paleogene time. Post-Cretaceous uplift transformed the zone from a primarily marine borderland into a marine archipelago that persisted until mid-Tertiary time.

  11. MIZEX. A Program for Mesoscale Air-Ice-Ocean Interaction Experiments in Arctic Marginal Ice Zones. II. A Science Plan for a Summer Marginal Ice Zone Experiment in the Fram Strait/Greenland Sea: 1984.

    Science.gov (United States)

    1983-05-01

    salinity, southward-flowing East Greenland Current from the more saline water in the Greenland Sea; or more transient, such as ice edge meltwater fronts... meltwater fronts) in the Fram Strait and Greenland Sea marginal ice zones? What is their temporal and spatial variability over a period of days? What is...three-dimensional structure of the fronts (East Greenland polar front and meltwater fronts) in the Fram Strait- Greenland Sea MIZ, their short-period

  12. Observations of Wind-Induced Motion in the Arctic Marginal Ice Zone

    Science.gov (United States)

    Bradley, A. C.; Palo, S. E.; Zappa, C. J.; LoDolce, G.; Weibel, D.; Lawrence, D.

    2014-12-01

    The increasingly recognized importance of the Marginal Ice Zone (MIZ) in the global and Arctic climate systems necessitates study of the complex processes at work in the interactions between ice floes, the ocean, and the atmosphere. This study uses observations of surface currents and floe drift speeds to explore the hydrodynamic processes driven by interactions with surface winds surrounding isolated small floes in the Arctic summertime MIZ. The 2013 MIZOPEX campaign flew several unmanned aircraft over the MIZ north of Oliktok Point, AK. These flights had two primary missions: dropping microbuoys into areas of open water between ice floes, and imaging in both thermal and visible using airborne systems. The Air-Deployed Micro Buoys (ADMB) drifted with surface currents, providing a measure of current speeds from the GPS track. ADMB were equipped with a string of thermistors extending two meters below the surface, which measured near-surface temperature gradients. Analysis of visible aerial imagery of ice floes is used to retrieve floe drift speeds from sequential photos by using aircraft telemetry to geolocate the images. Wind speeds from NCEP reanalysis and nearby met data are compared to surface currents and floe drift speeds; surface currents are approximately 4% of wind speeds, which agree well with lab measurements. Thermal imagery from the campaign show cold wakes at the surface near ice floes in certain wind conditions. The spatial view provided by airborne measurements, when combined with subsurface temperature gradients and the relation between drift and current speeds to local wind forcing, paints a picture of the physical interaction between an isolated ice floe in the MIZ and the open water surrounding it.

  13. Small-Scale Modeling of Waves and Floes in the Marginal Ice Zone

    Science.gov (United States)

    Orzech, M.; Shi, F.; Calantoni, J.; Bateman, S. P.; Veeramony, J.

    2014-12-01

    We are conducting a model-based investigation into the small-scale (O(m)) physics of wave-ice floe interaction in the marginal ice zone (MIZ), in order to test and improve parameterizations utilized by large-scale climate models. The presentation will describe the development and validation of a coupled system to track the wave-forced motion of floating objects (collections of bonded particles) and the concurrent effects of the moving objects on the surrounding fluid. NHWAVE, a fully dispersive wave model with a vertical sigma-coordinate, is extended to model moving objects by including vertical boundary fitted meshing and horizontal immersed boundary method. LIGGGHTS, a discrete element granular particle-tracking simulator, is configured to include realistic bonding forces between elements and incorporate velocity and pressure gradient effects from the fluid model. Following an overview of the coupled system, validation results will be presented for the standalone wave and ice models. For NHWAVE, model estimates of surface wave patterns generated by oscillating surface objects are compared to LIDAR measurements from corresponding laboratory experiments. For LIGGGHTS, the stress-strain response is measured for collections of bonded particles under tension and/or compression, then compared to available lab and field data. Results will also be presented from simplified MIZ simulations with the coupled system, in which waves pass through groups of rigid ice blocks and their refraction, diffraction, and reflection are measured. Finally, we will provide a preview of an upcoming series of targeted virtual experiments in which momentum/energy exchange between waves and ice floes is measured under varied conditions.

  14. Microbial methanogenesis in the sulfate-reducing zone of surface sediments traversing the Peruvian margin

    Science.gov (United States)

    Maltby, J.; Sommer, S.; Dale, A. W.; Treude, T.

    2016-01-01

    We studied the concurrence of methanogenesis and sulfate reduction in surface sediments (0-25 cm below sea floor) at six stations (70, 145, 253, 407, 990 and 1024 m) along the Peruvian margin (12° S). This oceanographic region is characterized by high carbon export to the seafloor creating an extensive oxygen minimum zone (OMZ) on the shelf, both factors that could favor surface methanogenesis. Sediments sampled along the depth transect traversed areas of anoxic and oxic conditions in the bottom-near water. Net methane production (batch incubations) and sulfate reduction (35S-sulfate radiotracer incubation) were determined in the upper 0-25 cm b.s.f. of multiple cores from all stations, while deep hydrogenotrophic methanogenesis (> 30 cm b.s.f., 14C-bicarbonate radiotracer incubation) was determined in two gravity cores at selected sites (78 and 407 m). Furthermore, stimulation (methanol addition) and inhibition (molybdate addition) experiments were carried out to investigate the relationship between sulfate reduction and methanogenesis.Highest rates of methanogenesis and sulfate reduction in the surface sediments, integrated over 0-25 cm b.s.f., were observed on the shelf (70-253 m, 0.06-0.1 and 0.5-4.7 mmol m-2 d-1, respectively), while lowest rates were discovered at the deepest site (1024 m, 0.03 and 0.2 mmol m-2 d-1, respectively). The addition of methanol resulted in significantly higher surface methanogenesis activity, suggesting that the process was mostly based on non-competitive substrates - i.e., substrates not used by sulfate reducers. In the deeper sediment horizons, where competition was probably relieved due to the decrease of sulfate, the usage of competitive substrates was confirmed by the detection of hydrogenotrophic activity in the sulfate-depleted zone at the shallow shelf station (70 m).Surface methanogenesis appeared to be correlated to the availability of labile organic matter (C / N ratio) and organic carbon degradation (DIC production

  15. 4D-Listmode-PET-CT and 4D-CT for optimizing PTV margins in gastric lymphoma. Determination of intra- and interfractional gastric motion

    Energy Technology Data Exchange (ETDEWEB)

    Reinartz, Gabriele; Haverkamp, Uwe; Wullenkord, Ramona; Lehrich, Philipp; Kriz, Jan; Eich, Hans Theodor [University Hospital Muenster, Department of Radiation Oncology, Muenster (Germany); Buether, Florian [University of Muenster, European Institute for Molecular Imaging (EIMI), Muenster (Germany); Schaefers, Klaus [University of Muenster, European Institute for Molecular Imaging (EIMI), Muenster (Germany); DFG EXC 1003, Cluster of Excellence ' Cells in Motion' , Muenster (Germany); Schaefers, Michael [University of Muenster, European Institute for Molecular Imaging (EIMI), Muenster (Germany); University Hospital Muenster, Department of Nuclear Medicine, Muenster (Germany); DFG EXC 1003, Cluster of Excellence ' Cells in Motion' , Muenster (Germany)

    2016-05-15

    New imaging protocols for radiotherapy in localized gastric lymphoma were evaluated to optimize planning target volume (PTV) margin and determine intra-/interfractional variation of the stomach. Imaging of 6 patients was explored prospectively. Intensity-modulated radiotherapy (IMRT) planning was based on 4D/3D imaging of computed tomography (CT) and positron-emission tomography (PET)-CT. Static and motion gross tumor volume (sGTV and mGTV, respectively) were distinguished by defining GTV (empty stomach), clinical target volume (CTV = GTV + 5 mm margin), PTV (GTV + 10/15/20/25 mm margins) plus paraaortic lymph nodes and proximal duodenum. Overlap of 4D-Listmode-PET-based mCTV with 3D-CT-based PTV (increasing margins) and V95/D95 of mCTV were evaluated. Gastric shifts were determined using online cone-beam CT. Dose contribution to organs at risk was assessed. The 4D data demonstrate considerable intra-/interfractional variation of the stomach, especially along the vertical axis. Conventional 3D-CT planning utilizing advancing PTV margins of 10/15/20/25 mm resulted in rising dose coverage of mCTV (4D-Listmode-PET-Summation-CT) and rising D95 and V95 of mCTV. A PTV margin of 15 mm was adequate in 3 of 6 patients, a PTV margin of 20 mm was adequate in 4 of 6 patients, and a PTV margin of 25 mm was adequate in 5 of 6 patients. IMRT planning based on 4D-PET-CT/4D-CT together with online cone-beam CT is advisable to individualize the PTV margin and optimize target coverage in gastric lymphoma. (orig.) [German] Zur Optimierung des Sicherheitsabstandes beim Planungszielvolumen (PTV) und zur Erfassung der intra-/interfraktionellen Variation des Magens wurden neue Protokolle fuer die Bildverarbeitung in der Radiotherapie lokalisierter Magenlymphome evaluiert. Die Bildgebung von 6 Patienten wurde prospektiv untersucht. Die Planung der intensitaetsmodulierten Strahlentherapie (IMRT) basierte auf 4D-/3D-Bildgebung von Computertomographie (CT) und Positronenemissionstomographie

  16. SWAP-70 controls formation of the splenic marginal zone through regulating T1B-cell differentiation.

    Science.gov (United States)

    Chopin, Michaël; Quemeneur, Laurence; Ripich, Tatsiana; Jessberger, Rolf

    2010-12-01

    T1 and T2 transitional B cells are precursors for marginal zone B cells (MZB), which surround splenic follicles. MZB are essential for marginal zone formation, are central to the innate immune response, and contribute to adaptive immunity. Differentiation, migration, and homing of MZB and their precursors remain to be fully understood. We show that SWAP-70, a RhoGTPase-interacting and F-actin-binding protein with functions in cell polarization, migration, and adhesion regulates MZB development and marginal zone formation. The percentage of MZB in spleen of Swap70(-/-) mice was reduced to about one-third of that found in WT mice. Swap70(-/-) T1 cells accumulated in integrin ligand(high) regions of the splenic red pulp and failed to efficiently develop into T2 cells. Adoptive transfer and mixed BM chimera experiments demonstrated this to be a B-cell intrinsic phenotype. T-cell-independent antibody production was not impaired, however, and thus suggests that this process does not require correct homing of MZB precursors. B-cell adhesion through α(L)β(2) and α(4)β(1) integrins was hyper-activated in vitro and on tissue sections, and S1P-stimulated chemokinesis of MZB was reduced in the absence of SWAP-70. Thus, SWAP-70 acts as a regulator of the adhesion process, particularly important for differentiation control of B-cell precursors and their contribution to splenic tissue formation.

  17. Miocene uplift of the NE Greenland margin linked to plate tectonics: Seismic evidence from the Greenland Fracture Zone, NE Atlantic

    DEFF Research Database (Denmark)

    Døssing Andreasen, Arne; Japsen, Peter; Watts, Anthony B.

    2016-01-01

    Tectonic models predict that, following breakup, rift margins undergo only decaying thermal subsidence during their post-rift evolution. However, post-breakup stratigraphy beneath the NE Atlantic shelves shows evidence of regional-scale unconformities, commonly cited as outer margin responses to ...... by plate tectonic forces, induced perhaps by a change in the Iceland plume (a hot pulse) and/or by changes in intra-plate stresses related to global tectonics.......Tectonic models predict that, following breakup, rift margins undergo only decaying thermal subsidence during their post-rift evolution. However, post-breakup stratigraphy beneath the NE Atlantic shelves shows evidence of regional-scale unconformities, commonly cited as outer margin responses...... to inner margin episodic uplift, including the formation of coastal mountains. The origin of these events remains enigmatic. We present a seismic reflection study from the Greenland Fracture Zone – East Greenland Ridge (GFZ-EGR) and the NE Greenland shelf. We document a regional intra-Miocene seismic...

  18. Geology of the Elephanta Island fault zone, western Indian rifted margin, and its significance for understanding the Panvel flexure

    Science.gov (United States)

    Samant, Hrishikesh; Pundalik, Ashwin; D'souza, Joseph; Sheth, Hetu; Lobo, Keegan Carmo; D'souza, Kyle; Patel, Vanit

    2017-02-01

    The Panvel flexure is a 150-km long tectonic structure, comprising prominently seaward-dipping Deccan flood basalts, on the western Indian rifted margin. Given the active tectonic faulting beneath the Panvel flexure zone inferred from microseismicity, better structural understanding of the region is needed. The geology of Elephanta Island in the Mumbai harbour, famous for the ca. mid-6th century A.D. Hindu rock-cut caves in Deccan basalt (a UNESCO World Heritage site) is poorly known. We describe a previously unreported but well-exposed fault zone on Elephanta Island, consisting of two large faults dipping steeply east-southeast and producing easterly downthrows. Well-developed slickensides and structural measurements indicate oblique slip on both faults. The Elephanta Island fault zone may be the northern extension of the Alibag-Uran fault zone previously described. This and two other known regional faults (Nhava-Sheva and Belpada faults) indicate a progressively eastward step-faulted structure of the Panvel flexure, with the important result that the individual movements were not simply downdip but also oblique-slip and locally even rotational (as at Uran). An interesting problem is the normal faulting, block tectonics and rifting of this region of the crust for which seismological data indicate a normal thickness (up to 41.3 km). A model of asymmetric rifting by simple shear may explain this observation and the consistently landward dips of the rifted margin faults.

  19. Geology of the Elephanta Island fault zone, western Indian rifted margin, and its significance for understanding the Panvel flexure

    Indian Academy of Sciences (India)

    Hrishikesh Samant; Ashwin Pundalik; Joseph D’souza; Hetu Sheth; Keegan Carmo Lobo; Kyle D’souza; Vanit Patel

    2017-02-01

    The Panvel flexure is a 150-km long tectonic structure, comprising prominently seaward-dipping Deccan flood basalts, on the western Indian rifted margin. Given the active tectonic faulting beneath the Panvel flexure zone inferred from microseismicity, better structural understanding of the region is needed. The geology of Elephanta Island in the Mumbai harbour, famous for the ca. mid-6th century A.D. Hindu rock-cut caves in Deccan basalt (a UNESCO World Heritage site) is poorly known. We describe a previously unreported but well-exposed fault zone on Elephanta Island, consisting of two large faults dippingsteeply east–southeast and producing easterly downthrows. Well-developed slickensides and structural measurements indicate oblique slip on both faults. The Elephanta Island fault zone may be the northern extension of the Alibag–Uran fault zone previously described. This and two other known regional faults (Nhava–Sheva and Belpada faults) indicate a progressively eastward step-faulted structure of the Panvel flexure, with the important result that the individual movements were not simply downdip but also oblique-slip and locally even rotational (as at Uran). An interesting problem is the normal faulting, block tectonics and rifting of this region of the crust for which seismological data indicate a normal thickness (up to 41.3 km). A model of asymmetric rifting by simple shear may explain this observation and the consistently landward dips of the rifted margin faults.

  20. Formation processes of floe size distribution in the marginal ice zone (Invited)

    Science.gov (United States)

    Toyota, T.; Kohout, A.; Fraser, A.

    2013-12-01

    Since the marginal ice zone (MIZ) is the outer sea ice zone, its behavior is key to the understanding of the variability of sea ice extent associated with climate change. Especially for the melting processes in MIZ, where relatively small ice floes are dominant, floe size distribution (FSD) is an important parameter because smaller ice floes are subject to stronger lateral melting due to their larger cumulative perimeters. As the MIZ is characterized by vigorous interaction between sea ice and waves, breakup of sea ice due to flexural forcing and collisions is considered to play an essential role in the determination of FSD there. However, the available data have been very limited so far. Analysis of the observations of ice floes with a heli-borne video camera, focusing on the floe size ranging from 2 m to 100 m, in the Sea of Okhotsk, the Weddell Sea and off East Antarctica, revealed that while FSD is basically scale-invariant, a regime shift occurs at a size of about a few tens of meters, irrespective of the study region. It was also shown 1) that the floe size at which regime shift occurs slightly increases from 20 to 40 m with ice thickness, consistent with the theory of the flexural failure of sea ice; and 2) that to explain the scale invariance in FSD for smaller floes, a fragility of sea ice which is relevant to the strength of sea ice relative to waves can be a useful physical parameter to be correlated with the fractal dimension. Thus these results confirm the importance of wave-ice interaction to the formation of FSD. Based on this, a possible mechanism of the melting process was hypothesized that in the melting season sea ice extent retreats keeping the FSD relative to the ice edge nearly constant. As a next step and to confirm and further investigate this result, we planned to conduct the concurrent measurements of FSD, wave activities, and ice thickness off East Antarctica during the Sea Ice Physics and Ecosystem Experiment 2 (SIPEX2) in September to

  1. Ice-Sheet Dynamics Of Warta Glaciation (SAALE In The Marginal Zone Of Knyszewicze Area, Northeastern Poland

    Directory of Open Access Journals (Sweden)

    Rychel Joanna

    2015-12-01

    Full Text Available The paper presents a research on a marginal zone near Knyszewicze in the southern part of Sokółka Hills (northeastern Poland. Terminal moraine hills are arranged amphitheatrically in a lobal pattern. Dynamics of the Knyszewicze frontal ice-sheet lobe during the Saale Glaciation and successive stages of the marginal zone near the village of Knyszewicze were reconstructed based on sedimentary and geomorphological analysis, using a digital elevation model and morpholineaments. Three main phases of the Knyszewicze glacial-lobe activity were identified including accumulation of glaciofluvial deposits, advances of the ice margin and ice-lobe retreat. Moraine hills developed at a stable ice-lobe terminus, initially as short end-moraine fans with the following sequence of lithofacies Gh⇒SGh⇒Sh or Gm⇒Gh⇒Sh. Such a sequence indicates cyclic sheet-floods. During a small but dynamic advance of the ice sheet terminus, these deposits were moved forward and monoclinally folded, then furrowed with sloping faults due to horizontal pressure. Typical thrust-block push moraines developed in this way. Ice sheet advance took place when permafrost was present in the substratum and very high water pressure occurred at glacial terminus. Inside a lobal configuration of moraines, there is a rich inventory of glacial forms with a classic terminal depression in the central part. Based on this landform pattern, their shape, rhythm and glaciotectonic disturbances, the land relief may be referred to as a hill-hole pair. The structure of Horczaki Knoll, deposited on the sub-Quaternary tectonic structure, significantly contributed to a development of this marginal zone.

  2. Prognostic Assessment in Patients with Indolent B-Cell Lymphomas

    Directory of Open Access Journals (Sweden)

    Luca Arcaini

    2012-01-01

    Full Text Available Follicular lymphoma (FL is an indolent lymphoma with long median survival. Many studies have been performed to build up prognostic scores potentially useful to identify patients with poorer outcome. In 2004, an international consortium coordinated by the International Follicular Lymphoma Prognostic Factor project was established and a new prognostic study was launched (FLIPI2 using progression-free survival (PFS as main endpoint and integrating all the modern parameters prospectively collected. Low-grade non-Hodgkin lymphomas were once considered as a heterogenous group of lymphomas characterized by an indolent clinical course. Each entity is characterized by unique clinicobiologic features. Some studies have been focused on prognostic factors in single lymphoma subtypes, with the development of specific-entity scores based on retrospective series, for instance splenic marginal zone lymphoma (SMZL. A widely accepted prognostic tool for clinical usage for indolent non-follicular B-cell lymphomas is largely awaited. In this paper we summarized the current evidence regarding prognostic assessment of indolent follicular and non-follicular lymphomas.

  3. New data on the period of existence of the continental margin subduction zone in the Middle Urals

    Science.gov (United States)

    Smirnov, V. N.; Ivanov, K. S.; Shokalsky, S. P.

    2016-12-01

    U-Pb (SIMS) dating of zircons from granite of the Petrokamensk gabbro-granitoid complex, marking termination of the Devonian island-arc magmatism in the Verkhisetsk-Tura Zone of the Middle Urals, gave an age of 386 ± 3 Ma. Zircons from the West Verkhisetsk granitoids, the formation of which corresponds to the beginning stage of magmatism of the continental margin in the region, yielded ages of 386.6 ± 4.1 and 381.8 ± 6.0 Ma. This suggests that the change in the regime of the island-arc geodynamic mode to an active continental margin took place at the boundary of the Middle and Late Devonian. The upper boundary of existence of the continental margin subduction zone is determined by the closure of the Ural paleo-ocean and the beginning of continental collision processes, which resulted in accumulation of flysch in the Ural foreland trough from the second half of the Bashkirian Stage.

  4. Miocene uplift of the NE Greenland margin linked to plate tectonics: Seismic evidence from the Greenland Fracture Zone, NE Atlantic.

    Science.gov (United States)

    Døssing, Arne; Japsen, Peter; Watts, Anthony; Nielsen, Tove; Jokat, Wilfried; Thybo, Hans

    2016-04-01

    Tectonic models predict that, following breakup, rift margins undergo only decaying thermal subsidence during their post-rift evolution. However, post-breakup stratigraphy beneath the NE Atlantic shelves shows evidence of regional-scale unconformities, commonly cited as outer margin responses to inner margin episodic uplift, including the formation of coastal mountains. The origin of these events remains enigmatic. We present a seismic reflection study from the Greenland Fracture Zone - East Greenland Ridge (GFZ-EGR) and the NE Greenland shelf. We document a regional intra-Miocene seismic unconformity (IMU), which marks the termination of syn-rift deposition in the deep-sea basins and onset of: (i) thermo-mechanical coupling across the GFZ, (ii) basin compression, and (iii) contourite deposition, north of the EGR. The onset of coupling across the GFZ is constrained by results of 2-D flexural backstripping. We explain the thermo-mechanical coupling and the deposition of contourites by the formation of a continuous plate boundary along the Mohns and Knipovich ridges, leading to an accelerated widening of the Fram Strait. We demonstrate that the IMU event is linked to onset of uplift and massive shelf-progradation on the NE Greenland margin. Given an estimated middle-to-late Miocene (~15-10 Ma) age of the IMU, we speculate that the event is synchronous with uplift of the East and West Greenland margins. The correlation between margin uplift and plate-motion changes further indicates that the uplift was triggered by plate tectonic forces, induced perhaps by a change in the Iceland plume (a hot pulse) and/or by changes in intra-plate stresses related to global tectonics.

  5. Investigations of Spatial and Temporal Variability of Ocean and Ice Conditions in and Near the Marginal Ice Zone. The “Marginal Ice Zone Observations and Processes Experiment” (MIZOPEX) Final Campaign Summary

    Energy Technology Data Exchange (ETDEWEB)

    DeMott, P. J. [Colorado State Univ., Fort Collins, CO (United States); Hill, T. C.J. [Colorado State Univ., Fort Collins, CO (United States)

    2016-02-01

    Despite the significance of the marginal ice zones of the Arctic Ocean, basic parameters such as sea surface temperature (SST) and a range of sea-ice characteristics are still insufficiently understood in these areas, and especially so during the summer melt period. The field campaigns summarized here, identified collectively as the “Marginal Ice Zone Ocean and Ice Observations and Processes Experiment” (MIZOPEX), were funded by U.S. National Aeronautic and Space Administration (NASA) with the intent of helping to address these information gaps through a targeted, intensive observation field campaign that tested and exploited unique capabilities of multiple classes of unmanned aerial systems (UASs). MIZOPEX was conceived and carried out in response to NASA’s request for research efforts that would address a key area of science while also helping to advance the application of UASs in a manner useful to NASA for assessing the relative merits of different UASs. To further exercise the potential of unmanned systems and to expand the science value of the effort, the field campaign added further challenges such as air deployment of miniaturized buoys and coordinating missions involving multiple aircraft. Specific research areas that MIZOPEX data were designed to address include relationships between ocean skin temperatures and subsurface temperatures and how these evolve over time in an Arctic environment during summer; variability in sea-ice conditions such as thickness, age, and albedo within the marginal ice zone (MIZ); interactions of SST, salinity, and ice conditions during the melt cycle; and validation of satellite-derived SST and ice concentration fields provided by satellite imagery and models.

  6. Hodgkin's Lymphoma

    Science.gov (United States)

    ... behavior. Your type determines your treatment options. Classical Hodgkin's lymphoma Classical Hodgkin's lymphoma is the more common ... Hodgkin's lymphoma Lymphocyte-rich Hodgkin's lymphoma Lymphocyte-predominant Hodgkin's lymphoma This much rarer type of Hodgkin's lymphoma ...

  7. IODP expedition 334: An investigation of the sedimentary record, fluid flow and state of stress on top of the seismogenic zone of an erosive subduction margin

    Digital Repository Service at National Institute of Oceanography (India)

    Vannucchi, P.; Ujiie, K.; Stroncik, N.; IODP Exp. 334 Scientific Party; Yatheesh, V.

    version: Sci. Drill.: 15; 2013; 23-30 IODP Expedition 334: An Investigation of the Sedimentary Record, Fluid Flow and State of Stress on Top of the Seismogenic Zone of an Erosive Subduction Margin Paola Vannucchi1, Kohtaro Ujiie2, Nicole Stroncik3..., N. and IODP Expedition 334 Scientific Party, 2013. IODP Expedition 334: An Investigation of the sedimentary record, fluid flow and state of stress on top of the seismogenic zone of an erosive subduction margin. Scientific Drilling, vol. 15, 23...

  8. Targeting of Ly9 (CD229) disrupts marginal zone and B1 B cell homeostasis and antibody responses1

    Science.gov (United States)

    Cuenca, Marta; Romero, Xavier; Sintes, Jordi; Terhorst, Cox; Engel, Pablo

    2015-01-01

    Marginal zone and B1 B-cells have the capacity to respond to foreign antigens more rapidly than conventional B-cells, providing early immune responses to blood-borne pathogens. Ly9 (CD229, SLAMF3), a member of the SLAM family receptors, has been implicated in the development and function of innate T lymphocytes. Here, we provide evidence that in Ly9-deficient mice splenic transitional T1, marginal zone and B1a B cells are markedly expanded, whilst development of B lymphocytes in bone marrow is unaltered. Consistent with an increased number of these B cell subsets, we detect elevated levels of IgG3 natural antibodies, and a striking increase of T-independent type II antibodies following immunization with TNP-Ficoll in the serum of Ly9-deficient mice. The notion that Ly9 could be a negative regulator of innate-like B cell responses was supported by the observation that administering a mAb directed against Ly9 to WT mice selectively eliminated splenic marginal zone B cells and significantly reduced the numbers of B1 and transitional T1 B cells. Additionally, Ly9 mAb dramatically diminished in vivo humoral responses and caused a selective down-regulation of the CD19/CD21/CD81 complex on B cells and concomitantly an impaired B cell survival and activation in a Fc-independent manner. We conclude that altered signaling due to the absence of Ly9 or induced by anti-Ly9 may negatively regulate development and function of innate-like B cells by modulating B cell activation thresholds. The results suggest that Ly9 could serve as a novel target for the treatment of B cell related diseases. PMID:26667173

  9. An Early Cretaceous volcanic arc/marginal basin transition zone, Peninsula hardy, southernmost Chile

    Science.gov (United States)

    Miller, Christopher A.; Barton, Michael; Hanson, Richard E.; Fleming, Thomas H.

    1994-10-01

    The Hardy Formation represents a latest Jurassic-Early Cretaceous volcanic arc that was located along the Pacific margin of southern South America. It was separated from the continent by a marginal basin floored by portions of an ophiolite sequence (the Rocas Verdes ophiolites). The transition between the arc and marginal basin occurs on Peninsula Hardy, southernmost Chile, where there is a lateral facies transition from arc deposits of the Hardy Formation into proximal marginal basin fill of the Yahgan Formation. Interfingering of arc and marginal basin sequences demonstrates that subduction-related arc magmatism was concurrent with marginal basin formation. The lateral facies transition is reflected in the geochemistry of volcanic rocks from the Hardy and Yahgan formations. Basalts, andesites and dacites of the arc sequence follow a calc-alkaline differentiation trend whereas basalts from the marginal basin follow a tholeiitic differentiation trend. Estimates of temperature and oxygen fugacity for crystallization of the arc andesites are similar to values reported for other calc-alkaline andesites. It is suggested that water activity influenced the early or late crystallization of Ti-magnetite and this controlled the style of differentiation of the magmas erupted on Peninsula Hardy. Magmas with high water contents evolved along the calc-alkaline differentiation trend whereas those with low water contents evolved along the tholeiitic differentiation trend. Some rhyolites are differentiated from the calc-alkaline andesites and dacites, but most appear to be the products of crustal anatexis on the basis of trace-element evidence. The arc basalts and some marginal basin basalts show relative enrichment in LILE, relative depletion in HFSE, and enrichment in LREE. Other marginal basin basalts are LREE depleted and show small relative depletions in HFSE. Basalts with both calc-alkaline and tholeiitic affinities can also be recognized in the Rocas Verdes ophiolites

  10. Wave-Ice interaction in the Marginal Ice Zone: Toward a Wave-Ocean-Ice Coupled Modeling System

    Science.gov (United States)

    2015-09-30

    concentration and thickness were taken from the Arctic Cap Nowcast/Forecast System (ACNFS), based on the Los Alamos Community Ice Code (CICE) with blending of... Special grids for WW3 were created which can run on a laptop and were tested during the mock “Plan of the Day” exercises prior to the cruise. An automated...measurements and analysis of ocean waves in the Antarctic marginal ice zone, Geophys. Res. Lett., 41, 5046–5051, doi:10.1002/2014GL060809. Mosig, J. E

  11. A malignant lymphoma with histological features and immunophenotypic profile intermediate between EBV-positive diffuse large B-cell lymphoma and EBV-positive classical Hodgkin lymphoma in a 67-year-old female: a "gray zone" lymphoma associated with Epstein-Barr virus in the elderly.

    Science.gov (United States)

    Wang, Endi; Papavassiliou, Paulie; Sebastian, Siby

    2012-06-15

    Epstein-Barr virus (EBV) can be associated with both classical Hodgkin lymphoma (cHL) and non-Hodgkin lymphoma of the B-cell type, particularly in immunodeficient patients or elderly individuals. While polymorphic variants of EBV-positive large B-cell lymphoma (EBV+ DLBCL) frequently resemble cHL in morphology, and thereby may cause diagnostic difficulty, a true gray zone lymphoma with overlapping morphological and immunophenotypical features of EBV+ DLBCL and EBV+ cHL has not been reported in the literature. We describe a unique case of an EBV+ malignant lymphoma of B-cell origin with hybrid features of EBV+ DLBCL and EBV+ cHL in a 67-year-old female without an identifiable etiology for immunodeficiency. The biopsy of an enlarged lymph node showed a polymorphic infiltrate containing Reed-Sternberg-like pleomorphic large cells, which were positive for CD30 and CD15. Although CD20 was negative and PAX5 and CD45 were down-regulated, the pleomorphic large cells expressed multiple other B-cell antigens which are characteristically absent in cHL. EBV-encoded RNA hybridization (EBER) studies demonstrated nuclear reactivity in the large cells as well as in the smaller bystander cells. A clonal rearrangement of the immunoglobulin heavy chain gene was also detected by PCR. Although the results of the EBV and genotypic studies suggest this case may be an example of EBV+ DLBCL of the elderly instead of EBV+ cHL, the immunophenotype is strikingly ambiguous. Thus, this case may represent an interface between EBV+ DLBCL and EBV+ cHL.

  12. Primary parotid gland lymphoma: a case report

    Directory of Open Access Journals (Sweden)

    Paraskevas Katsaronis

    2011-08-01

    Full Text Available Abstract Introduction Mucosa associated lymphoid tissue lymphomas are the most common lymphomas of the salivary glands. The benign lymphoepithelial lesion is also a lymphoproliferative disease that develops in the parotid gland. In the present case report, we describe one case of benign lymphoepithelial lesion with a subsequent low transformation to grade mucosa associated lymphoid tissue lymphoma appearing as a cystic mass in the parotid gland. Case presentation A 78-year-old Caucasian female smoker was referred to our clinic with a non-tender left facial swelling that had been present for approximately three years. The patient underwent resection of the left parotid gland with preservation of the left facial nerve through a preauricular incision. The pathology report was consistent with a low-grade marginal-zone B-cell non-Hodgkin lymphoma (mucosa associated lymphoid tissue lymphoma following benign lymphoepithelial lesion of the gland. Conclusions Salivary gland mucosa associated lymphoid tissue lymphoma should be considered in the differential diagnosis of cystic or bilateral salivary gland lesions. Parotidectomy is recommended in order to treat the tumor and to ensure histological diagnosis for further follow-up planning. Radiotherapy and chemotherapy should be considered in association with surgery in disseminated forms or after removal.

  13. A new view into the Cascadia subduction zone and volcanic arc: Implications for earthquake hazards along the Washington margin

    Science.gov (United States)

    Parsons, T.; Trehu, A.M.; Luetgert, J.H.; Miller, K.; Kilbride, F.; Wells, R.E.; Fisher, M.A.; Flueh, E.; ten Brink, U.S.; Christensen, N.I.

    1998-01-01

    In light of suggestions that the Cascadia subduction margin may pose a significant seismic hazard for the highly populated Pacific Northwest region of the United States, the U.S. Geological Survey (USGS), the Research Center for Marine Geosciences (GEOMAR), and university collaborators collected and interpreted a 530-km-long wide-angle onshore-offshore seismic transect across the subduction zone and volcanic arc to study the major structures that contribute to seismogenic deformation. We observed (1) an increase in the dip of the Juan de Fuca slab from 2??-7?? to 12?? where it encounters a 20-km-thick block of the Siletz terrane or other accreted oceanic crust, (2) a distinct transition from Siletz crust into Cascade arc crust that coincides with the Mount St. Helens seismic zone, supporting the idea that the mafic Siletz block focuses seismic deformation at its edges, and (3) a crustal root (35-45 km deep) beneath the Cascade Range, with thinner crust (30-35 km) east of the volcanic arc beneath the Columbia Plateau flood basalt province. From the measured crustal structure and subduction geometry, we identify two zones that may concentrate future seismic activity: (1) a broad (because of the shallow dip), possibly locked part of the interplate contact that extends from ???25 km depth beneath the coastline to perhaps as far west as the deformation front ???120 km offshore and (2) a crustal zone at the eastern boundary between the Siletz terrane and the Cascade Range.

  14. A sea ice model for the marginal ice zone with an application to the Greenland Sea

    DEFF Research Database (Denmark)

    Pedersen, Leif Toudal; Coon, Max D.

    2004-01-01

    A model is presented that describes the formation, transport, and desalinization of frazil and pancake ice as it is formed in marginal seas. This model uses as input the total ice concentration evaluated from Special Sensor Microwave Imager and wind speed and direction. The model calculates...... the areal concentration, thickness, volume concentration, and salinity of frazil ice as well as the areal concentration, thickness, and salinity of pancakes. A simple parameterization for the Odden region of the Greenland Sea is presented. The model is run for the winter of 1996-1997. There are direct...... observations of the thickness and salinity of pancakes and the volume concentration of frazil ice to compare with the model. The model results compare very well with the measured data. This new ice model can be tuned to work in marginal seas elsewhere to calculate ice thickness, motion, and brine rejection...

  15. Convergent margin structure and tectonics of the Java subduction zone (105°E-122°E)

    Science.gov (United States)

    Kopp, H.; Barckhausen, U.; Djajadihardja, Y.; Engels, M.; Flueh, E. R.; Hindle, D. A.; Lueschen, E.; Mueller, C.; Planert, L.; Reichert, C. J.; Shulgin, A. A.; Wittwer, A.

    2009-12-01

    The Java margin is the site of oceanic subduction of the Indo-Australian plate underneath the Indonesian archipelago. Data from a suite of geophysical experiments conducted between 1997-2006 using RV SONNE as platform include seismic and seismological studies, potential field measurements and high-resolution seafloor bathymetry mapping. Tomographic inversions provide an image of the ongoing deformation of the forearc and the deep subsurface. We investigate the role of various key mechanisms that shape the first-order features characterizing the present margin architecture. Our results show a high variability in subduction zone processes along the Java margin, ranging from accretionary subduction to erosive processes to zero-budget mass transfer. These variations are closely linked to changes in character of the incoming plate. Off Western Java (105°E -109°E), near-full accretion of the trench sediment fill is associated with a well-developed accretionary prism fronting a 4 km deep forearc basin. The Central Java segment (109°E -115°E) experiences the collision of an oceanic plateau dotted with numerous seamounts, causing large-scale uplift of the forearc, coupled with erosion of the frontal prism and correlated mass wasting processes. Intense deformation of the forearc basin results from thrusting and compressional forces. In the neighbouring segment farther to the east (115°E-119°E), the lack of significant sediment input to the trench supports the notion that recycling of upper plate material in the forearc sustains the massive outer high observed here adjacent to a mature forearc basin. The incoming oceanic plate of the Argo Abyssal plain is devoid of a sediment drape and the original spreading fabric overprinted by bending-related faulting near the trench shape its morphology. The transition zone from the Java margin to the Banda Arc (119°E-122°E) experiences the early stages of continent-island arc collision associated with the convergence of the

  16. Ins and outs of a complex subduction zone: C cycling along the Sunda margin, Indonesia

    Science.gov (United States)

    House, B. M.; Bebout, G. E.; Hilton, D. R.

    2016-12-01

    Subduction of C in marine sediments and altered oceanic crust is the main mechanism for reintroducing C into the deep earth and removing it from communication with the ocean and atmosphere. However, detailed studies of individual margins - which are necessary to understanding global C cycling - are sparse. The thick, C-rich sediment column along the Sunda margin, Indonesia makes understanding this margin crucial for constructing global C cycling budgets. Furthermore it is an ideal location to compare cycling of organic and carbonate C due to the abrupt transition from carbonate-dominated sediments in the SE to sediments rich in organic C from the Nicobar Fan in the NW. To quantify and characterize C available for subduction, we analyzed samples from DSDP 211, 260, 261, and ODP 765, all outboard of the trench, as well as piston and gravity cores of locally-sourced terrigenous trench fill. We created a 3-D model of overall sediment thickness and the thicknesses of geochemically distinct sedimentary units using archived and published seismic profiles to infer unit thicknesses at and along the 2500 km trench. This model vastly improves estimates of the C available for subduction and also reveals that the Christmas Island Seamount Province serves as a barrier to turbidite flow, dividing the regions of the trench dominated by organic and inorganic C input. Incorporating best estimates for the depth of the decollement indicates that the terrigenous trench fill, with up to 1.5 wt % organic C, is entirely accreted as is the thick section of carbonate-rich turbidites that dominate the southeastern portion of the margin (DSDP 261/ODP 765). Organic C accounts for most of the C bypassing the accretionary complex NW of the Christmas Island Seamount Province, and C inputs to the trench are lower there than to the SE where carbonate units near the base of the sediment column are the dominant C source. Release of C from altered oceanic crust - a C reservoir up to 10 times greater

  17. Seismogenic Coupling at Convergent Margins - Geophysical Observations from the South American Subduction Zone and the Alpine Rock Record

    Science.gov (United States)

    Oncken, O.

    2008-12-01

    Convergent continental margins are the Earth's principal locus of important earthquake hazards with nearly all interplate megathrust earthquakes (M>8) in the seismogenic coupling zone between the converging plates. Despite the key importance of this zone, the processes that shape it are poorly understood. This is underscored by a number of novel observations attributed to processes in the interface zone that are attracting increasing attention: silent slip events, non-volcanic tremors, afterslip, locked patches embedded in a creeping environment, etc. We here compare the rock record from a field study with recent results from two major geophysical experiments (ANCORP and TIPTEQ) that have imaged the South Chilean subduction zone at the site of the largest historically recorded earthquake (Valdivia, 1969; Mw = 9.5) and the plate boundary in Northern Chile, where a major seismic event is expected in the near future (Iquique segment). The reflection seismic data exhibit well defined changes of reflectivity and Vp/Vs ratio along the plate interface that can be correlated with different parts of the coupling zone as well as with changes during the seismic cycle. Observations suggest an important role of the hydraulic system. The rock record from the exhumed Early Tertiary seismogenic coupling zone of the European Alps provides indications for the mechanisms and processes responsible for the geophysical images. Fabric formation and metamorphism in a largely preserved subduction channel chiefly record the deformation conditions of the pre-collisional setting along the plate interface. We identify an unstable slip domain from pseudotachylytes occurring in the temperature range between 200-300°C. This zone coincides with a domain of intense veining in the subduction mélange with mineral growth into open cavities, indicating fast, possibly seismic, rupture. Evidence for transient near-lithostatic fluid pressure as well as brittle fractures competing with mylonitic shear

  18. Phytoplankton ice-edge blooms in the marginal ice zone at Princess Astrid Coast in Antarctica

    Digital Repository Service at National Institute of Oceanography (India)

    Verlecar, X.N.; Dhargalkar, V.K.; Goswami, S.C.; Mhamal, N.P.

    Daily variation in sea surface temperature at the ice edge zone in Antarctic polynya during summer from 25th December 1991 to 25th February 1992, showed that the values did not exceed 0 degrees C. Isotherms and isohalines showed vertically...

  19. In situ measurements of thermal diffusivity in sediments of the methane-rich zone of Cascadia Margin, NE Pacific Ocean

    Directory of Open Access Journals (Sweden)

    Kira Homola

    2015-02-01

    Full Text Available Abstract Thermal diffusivity (TD is a measure of the temperature response of a material to external thermal forcing. In this study, TD values for marine sediments were determined in situ at two locations on the Cascadia Margin using an instrumented sediment probe deployed by a remotely operated vehicle. TD measurements in this area of the NE Pacific Ocean are important for characterizing the upslope edge of the methane hydrate stability zone, which is the climate-sensitive boundary of a global-scale carbon reservoir. The probe was deployed on the Cascadia Margin at water depths of 552 and 1049 m for a total of 6 days at each site. The instrumented probe consisted of four thermistors aligned vertically, one sensor exposed to the bottom water and one each at 5, 10, and 15 cm within the sediment. Results from each deployment were analyzed using a thermal conduction model applying a range of TD values to obtain the best fit with the experimental data. TD values corresponding to the lowest standard deviations from the numerical model runs were selected as the best approximations. Overall TDs of Cascadia Margin sediments of 4.33 and 1.15 × 10–7 m2 s–1 were calculated for the two deployments. These values, the first of their kind to be determined from in situ measurements on a methane hydrate-rich continental margin, are expected to be useful in the development of models of bottom-water temperature increases and their implications on a global scale.

  20. Fluid-rock interaction in retrograde granulites of the Southern Marginal Zone, Limpopo high grade terrain, South Africa

    Directory of Open Access Journals (Sweden)

    Jan Marten Huizenga

    2014-09-01

    Full Text Available Fluid infiltration into retrograde granulites of the Southern Marginal Zone (Limpopo high grade terrain is exemplified by hydration reactions, shear zone hosted metasomatism, and lode gold mineralisation. Hydration reactions include the breakdown of cordierite and orthopyroxene to gedrite + kyanite, and anthophyllite, respectively. Metamorphic petrology, fluid inclusions, and field data indicate that a low H2O-activity carbon-saturated CO2-rich and a saline aqueous fluid infiltrated the Southern Marginal Zone during exhumation. The formation of anthophyllite after orthopyroxene established a regional retrograde anthophyllite-in isograd and occurred at P-T conditions of ∼6 kbar and 610 °C, which fixes the minimum mole fraction of H2O in the CO2-rich fluid phase at ∼0.1. The maximum H2O mole fraction is fixed by the lower temperature limit (∼800 °C for partial melting at ∼0.3. C-O-H fluid calculations show that the CO2-rich fluid had an oxygen fugacity that was 0.6 log10 units higher than that of the fayalite-magnetite-quartz buffer and that the CO2/(CO2+CH4 mole ratio of this fluid was 1. The presence of dominantly relatively low density CO2-rich fluid inclusions in the hydrated granulites indicates that the fluid pressure was less than the lithostatic pressure. This can be explained by strike slip faulting and/or an increase of the rock permeability caused by hydration reactions.

  1. Macrofaunal community structure in the western Indian continental margin including the oxygen minimum zone

    Digital Repository Service at National Institute of Oceanography (India)

    Ingole, B.S.; Sautya, S.; Sivadas, S.; Singh, R.; Nanajkar, M.

    group was abundant in the OMZ core (100 – 200 m) off Central Chile (Gallardo et al. 2004). Because these polychaetes are deposit-feeders (both surface and sub-surface), their predominance may reflect food availability (e.g. sediment C org and Chl... of stressful conditions such as the low DO (<0.5 ml l -1 ) has been observed in the OMZs of the Oman margin and off central Chile (Levin et al. 2000; Gallardo et al. 2004). Group 2 was restricted to the slope region (1001 m and 1524 m) where the SSDF...

  2. Left-lateral transtension along the Tierra Colorada deformation zone, northern margin of the Xolapa magmatic arc of southern Mexico

    Science.gov (United States)

    Riller, U.; Ratschbacher, L.; Frisch, W.

    1992-05-01

    Structural analysis of steeply NNW-dipping tectonites along the northern margin of the Xolapa magmatic arc, southern Mexico, reveals progressive deformation involving ductile and brittle deformation mechanisms. Ductile deformation detached Cretaceous cover rocks from the Xolapa basement along a crustal-scale mylonite zone with normal fault geometry. Normal faults dissected the mylonite zone into blocks which rotated a minimum of 35° to the north. Stress tensors calculated from fault-striae data show subhorizontal, roughly N/S-trending principal extension. Deformation resulted from differential uplift of the Xolapa magmatic arc with respect to its northern hinterland (Mixteca terrane). The oblique normal fault geometry of the mylonites conforms with strike-slip and dip-slip movements along the faults. Left-lateral transtension commenced ductilely between 90 Ma (age of deformed cover rocks) and 34 Ma (U/Pb zircon age of an undeformed pluton cutting the mylonite zone) and continued brittlely into the late Tertiary (tilted Miocene volcanic rocks). We argue that deformation resulted from the interaction of a left-lateral strike-slip regime established during formation of the Caribbean, and an extensional collapse of the Xolapa magmatic arc resulting from a change in steady-state plate-boundary conditions in the early Tertiary.

  3. Imprint of Southern Red Sea Major Tectonic Zone In A New Bouguer Anomaly Map of Southern Yemen Margin

    Science.gov (United States)

    Blecha, V.

    A new Bouguer anomaly map of western part of southern Yemen margin has been compiled. Densities of rock samples from main geological units (Precambrian base- ment, Mesozoic sediments, Tertiary volcanites) have been measured and used for grav- ity modeling. Regional gravity map indicates decrease of thickness of continental crust from volcanites of the Yemen Trap Series towards the coast of the Gulf of Aden. Most remarkable feature in the map of residual anomalies is a positive anomaly over the Dhala graben. The Dhala graben is a prominent geological structure in the area of study trending parallel to the Red Sea axis. Gravity modeling on a profile across the Dhala graben presumes intrusive plutonic rocks beneath the graben. There are two other areas in the southwestern tip of Arabia, which have essentially the same struc- tural position as the Dhala graben: the Jabal Tirf volcanic rift zone in the southern Saudi Arabia and Jabal Hufash extensional zone in northern Yemen. All three areas extend along the line trending parallel to the Red Sea axis with length of about 500 km. The line coincides with the axis of Afar (Danakil) depression after Arabia is shifted and rotated back to Africa. These facts imply conclusion that the Oligocene - Early Miocene magmatic activity on the Jabal Tirf - Dhala lineament is related to the same original deep tectonic zone, forming present-day Afar depression and still active.

  4. From rock to magma and back again: The evolution of temperature and deformation mechanism in conduit margin zones

    Science.gov (United States)

    Heap, Michael J.; Violay, Marie; Wadsworth, Fabian B.; Vasseur, Jérémie

    2017-04-01

    Explosive silicic volcanism is driven by gas overpressure in systems that are inefficient at outgassing. The zone at the margin of a volcanic conduit-thought to play an important role in the outgassing of magma and therefore pore pressure changes and explosivity-is the boundary through which heat is exchanged from the hot magma to the colder country rock. Using a simple heat transfer model, we first show that the isotherm for the glass transition temperature (whereat the glass within the groundmass transitions from a glass to an undercooled liquid) moves into the country rock when the magma within the conduit can stay hot, or into the conduit when the magma is quasi-stagnant and cools (on the centimetric scale over days to months). We then explore the influence of a migrating viscous boundary on compactive deformation micromechanisms in the conduit margin zone using high-pressure (effective pressure of 40 MPa), high-temperature (up to 800 °C) triaxial deformation experiments on porous andesite. Our experiments show that the micromechanism facilitating compaction in andesite is localised cataclastic pore collapse at all temperatures below the glass transition of the amorphous groundmass glass Tg (i.e., rock). In this regime, porosity is only reduced within the bands of crushed pores; the porosity outside the bands remains unchanged. Further, the strength of andesite is a positive function of temperature below the threshold Tg due to thermal expansion driven microcrack closure. The micromechanism driving compaction above Tg (i.e., magma) is the distributed viscous flow of the melt phase. In this regime, porosity loss is distributed and is accommodated by the widespread flattening and closure of pores. We find that viscous flow is much more efficient at reducing porosity than cataclastic pore collapse, and that it requires stresses much lower than those required to form bands of crushed pores. Our study therefore highlights that temperature excursions can result in a

  5. Clinical and pathological features of testicular diffuse large B-cell lymphoma: a heterogeneous disease.

    NARCIS (Netherlands)

    Kuper-Hommel, M.J.; Janssen-Heijnen, M.L.; Vreugdenhil, G.; Krol, A.D.; Kluin-Nelemans, H.C.; Coebergh, J.W.W.; Krieken, J.H.J.M. van

    2012-01-01

    Most testicular lymphomas are of diffuse large B-cell (DLBCL) type with an outcome inferior to nodal DLBCL. Within an apparently homogeneous group of testicular DLBCLs, small cell components, plasmacytoid differentiation and lymphoepithelial lesions (LELs), features of extranodal marginal zone

  6. Clinical and pathological features of testicular diffuse large B-cell lymphoma : a heterogeneous disease

    NARCIS (Netherlands)

    Kuper-Hommel, Marion J. J.; Janssen-Heijnen, Maryska L. G.; Vreugdenhil, Gerard; Krol, Augustinus D. G.; Kluin-Nelemans, Hanneke C.; Coebergh, Jan-Willem W.; van Krieken, J. Han J. M.

    2012-01-01

    Most testicular lymphomas are of diffuse large B-cell (DLBCL) type with an outcome inferior to nodal DLBCL. Within an apparently homogeneous group of testicular DLBCLs, small cell components, plasmacytoid differentiation and lymphoepithelial lesions (LELs), features of extranodal marginal zone lymph

  7. The NOTCH pathway is recurrently mutated in diffuse large B-cell lymphoma associated with hepatitis C virus infection.

    Science.gov (United States)

    Arcaini, Luca; Rossi, Davide; Lucioni, Marco; Nicola, Marta; Bruscaggin, Alessio; Fiaccadori, Valeria; Riboni, Roberta; Ramponi, Antonio; Ferretti, Virginia V; Cresta, Stefania; Casaluci, Gloria Margiotta; Bonfichi, Maurizio; Gotti, Manuel; Merli, Michele; Maffi, Aldo; Arra, Mariarosa; Varettoni, Marzia; Rattotti, Sara; Morello, Lucia; Guerrera, Maria Luisa; Sciarra, Roberta; Gaidano, Gianluca; Cazzola, Mario; Paulli, Marco

    2015-02-01

    Hepatitis C virus has been found to be associated with B-cell non-Hodgkin lymphomas, mostly marginal zone lymphomas and diffuse large B-cell lymphoma. Deregulation of signaling pathways involved in normal marginal zone development (NOTCH pathway, NF-κB, and BCR signaling) has been demonstrated in splenic marginal zone lymphoma. We studied mutations of NOTCH pathway signaling in 46 patients with hepatitis C virus-positive diffuse large B-cell lymphoma and in 64 patients with diffuse large B-cell lymphoma unrelated to HCV. NOTCH2 mutations were detected in 9 of 46 (20%) hepatitis C virus-positive patients, and NOTCH1 mutations in 2 of 46 (4%). By contrast, only one of 64 HCV-negative patients had a NOTCH1 or NOTCH2 mutation. The frequency of the NOTCH pathway lesions was significantly higher in hepatitis C virus-positive patients (P=0.002). The 5-year overall survival was 27% (95%CI: 5%-56%) for hepatitis C virus-positive diffuse large B-cell lymphoma patients carrying a NOTCH pathway mutation versus 62% (95%CI: 42%-77%) for those without these genetic lesions. By univariate analysis, age over 60 years, NOTCH2 mutation, and any mutation of the NOTCH pathway (NOTCH2, NOTCH1, SPEN) were associated with shorter overall survival. Mutation of the NOTCH pathway retained an independent significance (P=0.029). In conclusion, a subset of patients with hepatitis C virus-positive diffuse large B-cell lymphoma displays a molecular signature of splenic marginal zone and has a worse clinical outcome.

  8. Prevalence of Achromobacter xylosoxidans in pulmonary mucosa-associated lymphoid tissue lymphoma in different regions of Europe.

    Science.gov (United States)

    Adam, Patrick; Czapiewski, Piotr; Colak, Seba; Kosmidis, Perikles; Tousseyn, Thomas; Sagaert, Xavier; Boudova, Ludmila; Okoń, Krzysztof; Morresi-Hauf, Alicia; Agostinelli, Claudio; Pileri, Stefano; Pruneri, Giancarlo; Martinelli, Giovanni; Du, Ming-Qing; Fend, Falko

    2014-03-01

    Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises 7-8% of B-cell lymphomas and commonly originates from a background of long-standing chronic inflammation. An association with distinct bacteria species has been confirmed for several anatomical sites of MALT lymphoma. For pulmonary MALT lymphoma, however, a clear link with an infectious agent or autoimmune disorder has not yet been reported. Using a 16S rRNA gene-based approach, we have recently identified Achromobacter (Alcaligenes) xylosoxidans in eight of nine cases of pulmonary MALT lymphoma. A. xylosoxidans is a gram-negative betaproteobacterium with low virulence, but high resistance to antibiotic treatment. To further examine a potential association with A. xylosoxidans, 124 cases of pulmonary MALT lymphoma and 82 control tissues from six European countries were analysed using a specific nested PCR. Although prevalence rates for A. xylosoxidans varied significantly from country to country, they were consistently higher for MALT lymphoma as compared to controls. Overall, 57/124 (46%) pulmonary MALT lymphomas and 15/82 (18%) control tissues were positive for A. xylosoxidans (P = 0·004). Whether the significant association of A. xylosoxidans with pulmonary MALT lymphoma demonstrated in our study points to a potential causal role in the pathogenesis of this lymphoma will require further studies.

  9. Distribution of Phytoplankton and Particulate Organic Carbon in the Beaufort Sea during the 2014 Marginal Ice Zone Experiment

    Science.gov (United States)

    Perry, M. J.; Lee, C.; Yang, E. J.; Cetinic, I.; Kang, S. H.

    2014-12-01

    Spatial and temporal distributions of phytoplankton and particulate organic carbon in the newly emerging marginal ice zone in the Beaufort Sea are assessed from autonomous Seaglider surveys in summer 2014 as part of the Marginal Ice Zone (MIZ) Experiment, an international project sponsored by ONR. In late July 2014 four Seagliders were deployed in the Beaufort Sea to follow the retreat of the MIZ. Sampling in open water, through the MIZ and under the ice is expected through mid-September, with gliders navigating under ice from moored acoustic sound sources embedded in the MIZ autonomous observing array. The sensor suite carried by Seagliders include temperature, temperature microstructure, salinity, oxygen, chlorophyll fluorescence, optical backscatter, and multi-spectral downwelling irradiance. A rigorous sensor inter-calibration program with simultaneous ship CTD and glider profiles is an essential component of glider deployment and recovery protocol, as well as during opportunistic glider encounters with the IBRV Araon during August. Ship-based water sampling will allow construction of regional libraries of optical proxies for chlorophyll, pigment spectral absorption coefficient, and particulate organic carbon. Since irradiance under the ice is dependent on ice thickness and presence of melt ponds and leads, phytoplankton distribution is expected to vary spatially. Both the vertical and horizontal distributions of pigment spectral absorption coefficients are expected to play a role in the feedback between phytoplankton and ice melt. Glider data will allow us to apply a light and chlorophyll primary productivity model to estimate and compare phytoplankton productivity under various ice-cover and ice-free conditions.

  10. Paleomagnetic constraints on Cenozoic deformation along the northwest margin of the Pacific-Australian plate boundary zone through New Zealand

    Science.gov (United States)

    Turner, Gillian M.; Michalk, Daniel M.; Little, Timothy A.

    2012-02-01

    New Zealand straddles the boundary between the Australian and Pacific plates, a zone of oblique continental convergence and transform motion. The actively deforming region offers a unique opportunity to study the dynamics of deformation, including vertical-axis rotation of rigid blocks within a transcurrent plate boundary zone. We present and interpret paleomagnetic data from three new and three previously published sites from the NW part of the South Island (NW Nelson region), where sedimentary strata dated between 36 and 10 Ma overlie the crystalline Paleozoic basement assemblages of the Gondwana margin. Compared with reference directions from the Australian apparent polar wander path, none of the results provide evidence of post-Eocene vertical-axis rotation. This suggests that for the past 36 Myr NW Nelson has remained a strong, coherent block that has moved as a contiguous part of the Australian plate. This is in marked contrast to the strongly rotated nature of more outboard accreted terranes to the east. For example, the Hikurangi Margin in the North Island (NW of the Alpine Fault) and the Marlborough region in the NE of the South Island (SE of the Alpine Fault), have both undergone diverse clockwise rotations of up to 140° since the early Paleogene. The NW tip of the South Island seems to have acted as a rigid backstop relative to these more complex oroclinal deformations. We infer that, because of its relatively stiff bulk rheology, it has not been drawn into the distributed plate boundary rotational deformation associated with the New Zealand Orocline.

  11. Transverse, supraglacially derived crevasse infillings in a Pleistocene ice-sheet margin zone (eastern Poland): Genesis and sedimentary record

    Science.gov (United States)

    Godlewska, Anna; Terpiłowski, Sławomir

    2012-08-01

    The so-called 'crevasse infillings' in the marginal zone of the Saalian ice sheet in eastern Poland are atypical relief forms for lowlands glaciated in the Pleistocene. They are located on a high of the Cretaceous/Palaeogene substratum and form isolated ridges arranged in trains parallel to the former ice-sheet margin, i.e., transverse to the movement of the ice sheet. The sedimentary succession of the crevasse infillings consists mainly of undeformed glaciodeltaic deposits. We propose a model of the crevasse infilling development in three phases against the background of ice mass dynamics: 1) ice-sheet advance over a high of the substratum — compressive ice flow that bumped against the high's slope and enrichment of the ice with debris; 2) an overriding of the substratum high by ice masses — a tensional ice-flow regime resulted in significant crevassing; and 3) ice mass stagnation — low energy, supraglacial deltaic sedimentation in isolated ponds between disintegrated ice blocks under frozen bed conditions. Considering this genesis, we suggest classifying these forms as kames instead of crevasse infillings.

  12. Are rupture zone limits of great subduction earthquakes controlled by upper plate structures? Evidence from multichannel seismic reflection data acquired across the northern Ecuador-southwest Colombia margin

    Science.gov (United States)

    Collot, Jean-Yves; Marcaillou, Boris; Sage, FrançOise; Michaud, FrançOis; Agudelo, William; Charvis, Philippe; Graindorge, David; Gutscher, Marc-André; Spence, George

    2004-11-01

    Subduction of the Nazca plate beneath the Ecuador-Colombia margin has produced four megathrust earthquakes during the last century. The 500-km-long rupture zone of the 1906 (Mw = 8.8) event was partially reactivated by three thrust events, in 1942 (Mw = 7.8), 1958 (Mw = 7.7), and 1979 (Mw = 8.2), whose rupture zones abut one another. Multichannel seismic reflection and bathymetric data acquired during the SISTEUR cruise show evidence that the margin wedge is segmented by transverse crustal faults that potentially correlate with the limits of the earthquake coseismic slip zones. The Paleogene-Neogene Jama Quininde and Esmeraldas crustal faults define a ˜200-km-long margin crustal block that coincides with the 1942 earthquake rupture zone. Subduction of the buoyant Carnegie Ridge is inferred to partially lock the plate interface along central Ecuador. However, coseismic slip during the 1942 and 1906 earthquakes may have terminated against the subducted northern flank of the ridge. We report on a newly identified Manglares crustal fault that cuts transversally through the margin wedge and correlates with the limit between the 1958 and 1979 rupture zones. During the earthquake cycle the fault is associated with high-stress concentration on the plate interface. An outer basement high, which bounds the margin seaward of the 1958 rupture zone, may act as a deformable buttress to seaward propagation of coseismic slip along a megathrust splay fault. Coseismic uplift of the basement high is interpreted as the cause for the 1958 tsunami. We propose a model of weak transverse faults which reduce coupling between adjacent margin segments, together with a splay fault and an asperity along the plate interface as controlling the seismogenic rupture of the 1958 earthquake.

  13. Towards Resolving the Paradox of Antarctic Sea Ice: A New Integrated Framework for Observing the Antarctic Marginal Ice Zone

    Science.gov (United States)

    Williams, G. D.

    2014-12-01

    Antarctic sea ice distribution, a canary in the coal mine for climate change in the Southern Hemisphere, is controlled by the marginal ice zone (MIZ). The MIZ is the dynamic outer part of the sea-ice zone, where it interacts with the high-energy open ocean and is strongly affected by waves and storms. As an interface between ocean and atmosphere with extreme vertical and horizontal temperature gradients and large variations in mechanical properties, the MIZ is a complex system that evolves with, and impacts upon, the advancing/receding ice edge. More than a zone, it is a migratory transition in 'phase space' that biannually passes across the entire Antarctic SIZ. During the advance phase of sea-ice seasonality, and under freezing conditions, wave-induced pancake-ice formation can lead to rapid ice-edge advance. During the retreat phase, the dynamic break-up and modification of sea ice by passing storms, winds and waves greatly modifies the floe-size distribution within the MIZ, to create smaller floes that melt more rapidly and accelerate sea-ice retreat as spring progresses. Inspired by the current Arctic MIZ efforts, new fieldwork is proposed to resolve the key characteristics of the Antarctic MIZ and the processes controlling its extent. Combining new autonomous observation technology with ship-based techniques, integrated experiments are being designed to advance our understanding of the MIZ and its role in driving seasonal sea ice advance and retreat around Antarctica. The proposed project provides a unique opportunity to develop an observational, analytical, and science-policy framework for coordinated monitoring of sea ice in both the northern and southern hemispheres, with implications for forecasting, monitoring, and prediction that are essential with increasingly dynamic and variable polar climate systems.

  14. SAHKE geophysical transect reveals crustal and subduction zone structure at the southern Hikurangi margin, New Zealand

    Science.gov (United States)

    Henrys, S.; Wech, A.; Sutherland, R.; Stern, T.; Savage, M.; Sato, H.; Mochizuki, K.; Iwasaki, T.; Okaya, D.; Seward, A.; Tozer, B.; Townend, J.; Kurashimo, E.; Iidaka, T.; Ishiyama, T.

    2013-07-01

    The Seismic Array Hikurangi Experiment (SAHKE) investigated the structure of the forearc and subduction plate boundary beneath the southern North Island along a 350 km transect. Tomographic inversion of first-arrival travel times was used to derive a well-resolved 15-20 km deep P wave image of the crust. The refracted phases and migrated reflection events image subducting slab geometry and crustal structure. In the west, Australian Plate Moho depth decreases westward across the Taranaki Fault system from 35 to ˜28-30 km. In the east, subducted Pacific Plate oceanic crust is recognized to have a positive velocity gradient, but becomes less distinct beneath the Tararua Ranges, where the interface increases in dip at about 15 km depth from 15°. This bend in the subducted plate is associated with vertical clusters in seismicity, splay fault branching, and low-velocity high-attenuation material that we interpret to be an underplated subduction sedimentary channel. We infer that a step down in the decollément transfers slip on the plate interface at the top of a subduction channel to the oceanic crust and drives local uplift of the Tararua Ranges. Reflections from the Wairarapa Fault show that it is listric and soles into the top of underplated sediments, which in turn abut the Moho of the overriding plate at ˜32 km depth, near the downdip end of the strongly locked zone. The change in dip of the Hikurangi subduction interface is spatially correlated with the transition from geodetically determined locked to unlocked areas of the plate interface.

  15. Paleogene tectono-sedimentary evolution of the Alicante Trough (External Betic Zone, SE Spain) and its bearing on the timing of the deformation of the South-Iberian Margin

    OpenAIRE

    Guerrera, Francesco; Estévez Rubio, Antonio; López Arcos, Mariano; Martín Martín, Manuel; Martín Pérez, Juan Antonio; Serrano Lozano, Francisco

    2006-01-01

    The Paleogene Alicante Trough of the South-Iberian Margin (External Betic Zone) consists of a narrow sedimentary basin that has active margins located to the north-northwest (active mainly during the Eocene) and to the south-southeast (active during the Oligocene). Both margins, consisting of shallow unstable platforms, were the source areas for the external-platform slope (in the opposite margins) and deepbasin (in the middle) depositional realms. The southern margin, lost under the Mediterr...

  16. Diverse hematological malignancies including hodgkin-like lymphomas develop in chimeric MHC class II transgenic mice.

    Directory of Open Access Journals (Sweden)

    Silke H Raffegerst

    Full Text Available A chimeric HLA-DR4-H2-E (DR4 homozygous transgenic mouse line spontaneously develops diverse hematological malignancies with high frequency (70%. The majority of malignancies were distributed equally between T and B cell neoplasms and included lymphoblastic T cell lymphoma (LTCL, lymphoblastic B cell lymphoma (LBCL, diffuse large B cell lymphoma (DLBCL, the histiocyte/T cell rich variant of DLBCL (DLBCL-HA/T cell rich DLBCL, splenic marginal zone lymphoma (SMZL, follicular B cell lymphoma (FBL and plasmacytoma (PCT. Most of these neoplasms were highly similar to human diseases. Also, some non-lymphoid malignancies such as acute myeloid leukemia (AML and histiocytic sarcoma were found. Interestingly, composite lymphomas, including Hodgkin-like lymphomas, were also detected that had CD30(+ Hodgkin/Reed-Sternberg (H/RS-like cells, representing a tumor type not previously described in mice. Analysis of microdissected H/RS-like cells revealed their origin as germinal center B cells bearing somatic hypermutations and, in some instances, crippled mutations, as described for human Hodgkin lymphoma (HL. Transgene integration in an oncogene was excluded as an exclusive driving force of tumorigenesis and age-related lymphoma development suggests a multi-step process. Thus, this DR4 line is a useful model to investigate common molecular mechanisms that may contribute to important neoplastic diseases in man.

  17. Structure and function of nematode communities across the Indian western continental margin and its oxygen minimum zone

    Science.gov (United States)

    Singh, R.; Ingole, B. S.

    2016-01-01

    We studied patterns of nematode distribution along the western Indian continental margin to determine the influence of habitat heterogeneity and low oxygen levels on the community's taxonomic and functional structure. A single transect, perpendicular to the coast at 14° N latitude was sampled from 34 to 2546 m depth for biological and environmental variables during August 2007. The oxygen minimum zone extended from 102 to 1001 m. Nematodes (described and undescribed) were identified to species and classified according to biological and functional traits. A total of 110 nematode species belonging to 24 families were found along the transect. Three depth zones were identified: the shelf (depth range: 34-102 m; highest nematode mean density: 176.6 ± 37 ind 10 cm-2), the slope (525-1524 m; 124.3 ± 16 ind 10 cm-2), and the basin (2001-2546 m; 62.9 ± 2 ind 10 cm-2). Across the entire study area, the dominant species were Terschellingia longicaudata, Desmodora sp. 1, Sphaerolaimus gracilis, and Theristus ensifer; their maximum density was at shelf stations. Nematode communities in different zones differed in species composition. Chromadorita sp. 2 (2.78 %) and Sphaerolaimus gracilis (2.21 %) were dominant on the shelf, whereas Terschellingia longicaudata (4.73 %) and Desmodora sp. 1 (4.42 %) were dominant on the slope, but in the basin, Halalaimus sp. 1(1.11 %) and Acantholaimus elegans (1.11 %) were dominant. The information in a particular functional group was not a simple reflection of the information in species abundance. Ecological information captured by adult length, adult shape, and life-history strategy was less site-specific and thus differed notably from information contained in other taxonomic groups. The functional composition of nematodes was strongly linked to the organic-carbon and dissolved-oxygen concentration. Seven species were found exclusively in the oxygen minimum zone: Pselionema sp. 1, Choanolaimus sp. 2, Halichoanolaimus sp. 1, Cobbia dentata

  18. Factors controlling phytoplankton ice-edge blooms in the marginal ice-zone of the northwestern Weddell Sea during sea ice retreat 1988 : field observations and mathematical modelling

    NARCIS (Netherlands)

    Lancelot, Christiane; Mathot, Sylvie; Veth, Cornelis; Baar, Hein de

    1993-01-01

    The factors controlling phytoplankton bloom development in the marginal ice zone of the northwestern Weddell Sea were investigated during the EPOS (Leg 2) expedition (1988). Measurements were made of physical and chemical processes and biological activities associated with the process of ice-melting

  19. Factors controlling phytoplankton ice-edge blooms in the marginal ice-zone of the northwestern Weddell Sea during sea ice retreat 1988 : field observations and mathematical modelling

    NARCIS (Netherlands)

    Lancelot, Christiane; Mathot, Sylvie; Veth, Cornelis; Baar, Hein de

    1993-01-01

    The factors controlling phytoplankton bloom development in the marginal ice zone of the northwestern Weddell Sea were investigated during the EPOS (Leg 2) expedition (1988). Measurements were made of physical and chemical processes and biological activities associated with the process of ice-melting

  20. Evolution of a Directional Wave Spectrum in a 3D Marginal Ice Zone with Random Floe Size Distribution

    Science.gov (United States)

    Montiel, F.; Squire, V. A.

    2013-12-01

    A new ocean wave/sea-ice interaction model is proposed that simulates how a directional wave spectrum evolves as it travels through a realistic marginal ice zone (MIZ), where wave/ice dynamics are entirely governed by coherent conservative wave scattering effects. Field experiments conducted by Wadhams et al. (1986) in the Greenland Sea generated important data on wave attenuation in the MIZ and, particularly, on whether the wave spectrum spreads directionally or collimates with distance from the ice edge. The data suggest that angular isotropy, arising from multiple scattering by ice floes, occurs close to the edge and thenceforth dominates wave propagation throughout the MIZ. Although several attempts have been made to replicate this finding theoretically, including by the use of numerical models, none have confronted this problem in a 3D MIZ with fully randomised floe distribution properties. We construct such a model by subdividing the discontinuous ice cover into adjacent infinite slabs of finite width parallel to the ice edge. Each slab contains an arbitrary (but finite) number of circular ice floes with randomly distributed properties. Ice floes are modeled as thin elastic plates with uniform thickness and finite draught. We consider a directional wave spectrum with harmonic time dependence incident on the MIZ from the open ocean, defined as a continuous superposition of plane waves traveling at different angles. The scattering problem within each slab is then solved using Graf's interaction theory for an arbitrary incident directional plane wave spectrum. Using an appropriate integral representation of the Hankel function of the first kind (see Cincotti et al., 1993), we map the outgoing circular wave field from each floe on the slab boundaries into a directional spectrum of plane waves, which characterizes the slab reflected and transmitted fields. Discretizing the angular spectrum, we can obtain a scattering matrix for each slab. Standard recursive

  1. Lower Paleozoic Continuity of the East Gondwanan Margin and Implications for Interpretation of Tectonostratigraphic Zones of the Himalaya

    Science.gov (United States)

    Myrow, P.; Hughes, N.; Fanning, C. M.; Banerjee, D.; Dipietro, J. A.

    2009-12-01

    Qualitative and quantitative study of the tectonic and erosional history of the Himalayan orogen requires knowledge of the geology prior to major unroofing. Our studies of sedimentary successions in the Lesser (LH) and Tethyan Himalaya (TH)support depositional and stratigraphic continuity of the lower Paleozoic Indian Gondwanan margin across the various lithotectonic zones of the Himalaya, and along strike, from beyond the western Himalayan syntaxis in Pakistan, to Arunachal Pradesh, adjacent to the eastern syntaxis. Across-strike continuity is supported by (1) the presence of a distinctive Cambrian-Permian unconformity in the Salt Range (south of the Main Boundary Thrust), LH of India, and northern Tethyan part of Pakistan, and (2) correlative Neoproterozoic diamictite units in both the TH and LH. In addition, lithofacies changes support northward deepening across the northern Indian margin from the LH to the TH. Cambrian rocks extended south of the MBT in the Salt Range of Pakistan and are also exposed on cratonic India, south of the Himalayan Frontal Thrust in the Marwar basin of Rajasthan. Correlations indicate that the Neoproterozoic-Cambrian blanket extended far onto the Indian craton, just as on other paleocontinents at this time. Along-strike stratigraphic relationships also support the existence this extensive blanket, from which the outer Lesser Himalaya is a remnant. Similarities in stratigraphic successions, depositional ages, and geochemical deposits (e.g., phosphate) of the LH and TH between the central Himalaya and Pakistan, as well as correlative Neoproterozoic carbonate in Arunachal Pradesh (Buxa Formation), indicate that this blanket extended from west of the western syntax of the Himalaya across to the eastern syntaxis. Detrital zircon age spectra from Cambrian and Ordovician samples across the ancient northern Indian Himalayan margin show uniform signatures that include age ranges from Archean to Ordovician, with dominant of 1.3-0.9 Ga, ~0

  2. The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue.

    Science.gov (United States)

    Wan, Yinan; Almeida, Alexandra D; Rulands, Steffen; Chalour, Naima; Muresan, Leila; Wu, Yunmin; Simons, Benjamin D; He, Jie; Harris, William A

    2016-04-01

    Clonal analysis is helping us understand the dynamics of cell replacement in homeostatic adult tissues (Simons and Clevers, 2011). Such an analysis, however, has not yet been achieved for continuously growing adult tissues, but is essential if we wish to understand the architecture of adult organs. The retinas of lower vertebrates grow throughout life from retinal stem cells (RSCs) and retinal progenitor cells (RPCs) at the rim of the retina, called the ciliary marginal zone (CMZ). Here, we show that RSCs reside in a niche at the extreme periphery of the CMZ and divide asymmetrically along a radial (peripheral to central) axis, leaving one daughter in the peripheral RSC niche and the other more central where it becomes an RPC. We also show that RPCs of the CMZ have clonal sizes and compositions that are statistically similar to progenitor cells of the embryonic retina and fit the same stochastic model of proliferation. These results link embryonic and postembryonic cell behaviour, and help to explain the constancy of tissue architecture that has been generated over a lifetime.

  3. The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue

    Science.gov (United States)

    Wan, Yinan; Almeida, Alexandra D.; Rulands, Steffen; Chalour, Naima; Muresan, Leila; Wu, Yunmin; Simons, Benjamin D.; He, Jie; Harris, William A.

    2016-01-01

    Clonal analysis is helping us understand the dynamics of cell replacement in homeostatic adult tissues (Simons and Clevers, 2011). Such an analysis, however, has not yet been achieved for continuously growing adult tissues, but is essential if we wish to understand the architecture of adult organs. The retinas of lower vertebrates grow throughout life from retinal stem cells (RSCs) and retinal progenitor cells (RPCs) at the rim of the retina, called the ciliary marginal zone (CMZ). Here, we show that RSCs reside in a niche at the extreme periphery of the CMZ and divide asymmetrically along a radial (peripheral to central) axis, leaving one daughter in the peripheral RSC niche and the other more central where it becomes an RPC. We also show that RPCs of the CMZ have clonal sizes and compositions that are statistically similar to progenitor cells of the embryonic retina and fit the same stochastic model of proliferation. These results link embryonic and postembryonic cell behaviour, and help to explain the constancy of tissue architecture that has been generated over a lifetime. PMID:26893352

  4. Sedimentary pigments and nature of organic matter within the oxygen minimum zone (OMZ) of the Eastern Arabian Sea (Indian margin)

    Science.gov (United States)

    Rasiq, K. T.; Kurian, S.; Karapurkar, S. G.; Naqvi, S. W. A.

    2016-07-01

    Sedimentary pigments, carbon and nitrogen content and their stable isotopes were studied in three short cores collected from the oxygen minimum zone (OMZ) of the Eastern Arabian Sea (EAS). Nine pigments including chlorophyll a and their degradation products were quantified using High Performance Liquid Chromatography (HPLC). Astaxanthin followed by canthaxanthin and zeaxanthin were the major carotenoids detected in these cores. The total pigment concentration was high in the core collected from 500 m water depth (6.5 μgg-1) followed by 800 m (1.7 μgg-1) and 1100 m (1.1 μgg-1) depths respectively. The organic carbon did not have considerable control on sedimentary pigments preservation. Pigment degradation was comparatively high in the core collected from the 800 m site which depended not only the bottom dissolved oxygen levels, but also on the faunal activity. As reported earlier, the bottom water dissolved oxygen and presence of fauna have good control on the organic carbon accumulation and preservation at Indian margin OMZ sediments. The C/N ratios and δ13C values for all the cores conclude the marine origin of organic matter and δ15N profiles revealed signature of upwelling associated denitrification within the water column.

  5. A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development.

    Science.gov (United States)

    Chen, Yuhong; Yu, Mei; Podd, Andrew; Wen, Renren; Chrzanowska-Wodnicka, Magdalena; White, Gilbert C; Wang, Demin

    2008-05-01

    B-cell development is orchestrated by complex signaling networks. Rap1 is a member of the Ras superfamily of small GTP-binding proteins and has 2 isoforms, Rap1a and Rap1b. Although Rap1 has been suggested to have an important role in a variety of cellular processes, no direct evidence demonstrates a role for Rap1 in B-cell biology. In this study, we found that Rap1b was the dominant isoform of Rap1 in B cells. We discovered that Rap1b deficiency in mice barely affected early development of B cells but markedly reduced marginal zone (MZ) B cells in the spleen and mature B cells in peripheral and mucosal lymph nodes. Rap1b-deficient B cells displayed normal survival and proliferation in vivo and in vitro. However, Rap1b-deficient B cells had impaired adhesion and reduced chemotaxis in vitro, and lessened homing to lymph nodes in vivo. Furthermore, we found that Rap1b deficiency had no marked effect on LPS-, BCR-, or SDF-1-induced activation of mitogen-activated protein kinases and AKT but clearly impaired SDF-1-mediated activation of Pyk-2, a key regulator of SDF-1-mediated B-cell migration. Thus, we have discovered a critical and distinct role of Rap1b in mature B-cell trafficking and development of MZ B cells.

  6. Trophic interactions of macro-zooplankton (krill and amphipods) in the Marginal Ice Zone of the Barents Sea

    Science.gov (United States)

    Dalpadado, Padmini; Yamaguchi, Atsushi; Ellertsen, Bjørnar; Johannessen, Signe

    2008-10-01

    The diets of krill and amphipods were examined using light microscopy on field-collected specimens from 2004 to 2005 from the Marginal Ice Zone of the northwestern Barents Sea, north and east of Spitsbergen. Stomach content analyses indicate dominant krill species to have a filter-feeding mode, whereas amphipods seem to be mainly raptorial feeders. The dominant krill, Thysanoessa inermis, is primarily regarded as an herbivore feeding mostly on diatoms. Alternatively, Thysanoessa longicaudata fed occasionally on calanoid copepods in addition to being a suspension feeder on phytoplankton. The largest of the krill species, Meganyctiphanes norvegica, showed a mixed diet with regular feeding on calanoid copepods and phytoplankton. The degree of carnivory varied between stations and was determined by examining the size and shape of the mandible of copepods. M. norvegica, with a total length of between 26 and 41 mm, had up to two copepods in their stomachs, with a mandible width of the copepods varying from 32 to 154 μm, corresponding, respectively, to a computed prosome length of 0.3 and 2.6 mm. Themisto libellula fed primarily on C3 and C4 copepodite stages of Calanus glacialis and Calanus hyperboreus, and up to three copepods were found in the stomach contents of T. libellula. Themisto abyssorum fed on herbivorous and omnivorous prey such as copepods and appendicularians. The presence of Metridia spp. and appendicularians, e.g., Oikopleura vanhoeffeni in the diet of T. abyssorum may indicate feeding in the deeper layers (>200 m).

  7. Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet.

    Science.gov (United States)

    Nus, Meritxell; Sage, Andrew P; Lu, Yuning; Masters, Leanne; Lam, Brian Y H; Newland, Stephen; Weller, Sandra; Tsiantoulas, Dimitrios; Raffort, Juliette; Marcus, Damiënne; Finigan, Alison; Kitt, Lauren; Figg, Nichola; Schirmbeck, Reinhold; Kneilling, Manfred; Yeo, Giles S H; Binder, Christoph J; de la Pompa, José Luis; Mallat, Ziad

    2017-05-01

    Splenic marginal zone B (MZB) cells, positioned at the interface between circulating blood and lymphoid tissue, detect and respond to blood-borne antigens. Here we show that MZB cells in mice activate a homeostatic program in response to a high-cholesterol diet (HCD) and regulate both the differentiation and accumulation of T follicular helper (TFH) cells. Feeding mice an HCD resulted in upregulated MZB cell surface expression of the immunoregulatory ligand PDL1 in an ATF3-dependent manner and increased the interaction between MZB cells and pre-TFH cells, leading to PDL1-mediated suppression of TFH cell motility, alteration of TFH cell differentiation, reduced TFH abundance and suppression of the proatherogenic TFH response. Our findings reveal a previously unsuspected role for MZB cells in controlling the TFH-germinal center response to a cholesterol-rich diet and uncover a PDL1-dependent mechanism through which MZB cells use their innate immune properties to limit an exaggerated adaptive immune response.

  8. Expression of Immunoglobulin Receptors with Distinctive Features Indicating Antigen Selection by Marginal Zone B Cells from Human Spleen

    Science.gov (United States)

    Colombo, Monica; Cutrona, Giovanna; Reverberi, Daniele; Bruno, Silvia; Ghiotto, Fabio; Tenca, Claudya; Stamatopoulos, Kostas; Hadzidimitriou, Anastasia; Ceccarelli, Jenny; Salvi, Sandra; Boccardo, Simona; Calevo, Maria Grazia; De Santanna, Amleto; Truini, Mauro; Fais, Franco; Ferrarini, Manlio

    2013-01-01

    Marginal zone (MZ) B cells, identified as surface (s)IgMhighsIgDlowCD23low/−CD21+CD38− B cells, were purified from human spleens, and the features of their V(D)J gene rearrangements were investigated and compared with those of germinal center (GC), follicular mantle (FM) and switched memory (SM) B cells. Most MZ B cells were CD27+ and exhibited somatic hypermutations (SHM), although to a lower extent than SM B cells. Moreover, among MZ B-cell rearrangements, recurrent sequences were observed, some of which displayed intraclonal diversification. The same diversifying sequences were detected in very low numbers in GC and FM B cells and only when a highly sensitive, gene-specific polymerase chain reaction was used. This result indicates that MZ B cells could expand and diversify in situ and also suggested the presence of a number of activation-induced cytidine deaminase (AID)-expressing B cells in the MZ. The notion of antigen-driven expansion/selection in situ is further supported by the VH CDR3 features of MZ B cells with highly conserved amino acids at specific positions and by the finding of shared (“stereotyped”) sequences in two different spleens. Collectively, the data are consistent with the notion that MZ B cells are a special subset selected by in situ antigenic stimuli. PMID:23877718

  9. The Teisseyre-Tornquist Zone - early Palaeozoic strike-slip plate boundary or Ediacaran rifted margin of Baltica?

    Science.gov (United States)

    Mazur, Stanislaw; Krzywiec, Piotr; Malinowski, Michal; Lewandowski, Marek; Buffenmeyer, Vinton; Green, Christopher

    2016-04-01

    The Teisseyre-Tornquist Zone (TTZ) is the longest European tectonic and geophysical lineament extending from the Baltic Sea in the northwest to the Black Sea in the southeast. This tectonic feature defines a transition between the thick crust of the East European Craton (EEC) and the thinner crust of the Palaeozoic Platform to the southwest. Being a profound zone of crustal and lithospheric thickness perturbation, the TTZ has usually been considered a Caledonian tectonic suture formed due to the closure of the Tornquist Ocean. The suture was hypothesised to originate from the collision between Baltica and Avalonia or large-scale strike-slip displacement along strike of the Caledonian Orogen. However, some minority views postulated the continuation of Baltica crystalline basement farther to the southwest up to the Elbe Lineament and the margin of the Variscan Belt. We studied the ION Geophysical PolandSPAN survey that consists of 10 regional, seismic depth profiles covering the SW margin of the EEC and the TTZ in Poland. Since the PolandSPAN profiles image to ~30 km depth their interpretation was integrated with the potential fields data and earlier results of refraction sounding to better image the deep structure of the TTZ. Our data show that the NW and central sections of the TTZ correspond, at the Moho level, to a relatively narrow crustal keel and a significant Moho step at the transition from the EEC to the Palaeozoic Platform. However, top of basement above the TTZ is smooth and moderately sloping towards the southwest. In the central part of the TTZ, top of Precambrian is covered by undisturbed lower Palaeozoic sediments. In contrast, the lower Palaeozoic sediments are involved in a latest Silurian, thin-skinned fold-and-thrust belt along the NW section of the TTZ, where the sharply defined Caledonian Deformation Front adjoins a rigid basement buttress above the TTZ. Finally, the crustal keel is mostly missing from the SE section of the TTZ. Instead, this

  10. The anti-lymphoma activity of antiviral therapy in HCV-associated B-cell non-Hodgkin lymphomas: a meta-analysis.

    Science.gov (United States)

    Peveling-Oberhag, J; Arcaini, L; Bankov, K; Zeuzem, S; Herrmann, E

    2016-07-01

    Many epidemiological studies provide solid evidence for an association of chronic hepatitis C virus (HCV) infection with B-cell non-Hodgkin's lymphoma (B-NHL). However, the most convincing evidence for a causal relationship between HCV infection and lymphoma development is the observation of B-NHL regression after HCV eradication by antiviral therapy (AVT). We conducted a literature search to identify studies that included patients with HCV-associated B-NHL (HCV-NHL) who received AVT, with the intention to treat lymphoma and viral disease at the same time. The primary end point was the correlation of sustained virological response (SVR) under AVT with lymphoma response. Secondary end points were overall lymphoma response rates and HCV-NHL response in correlation with lymphoma subtypes. We included 20 studies that evaluated the efficacy of AVT in HCV-NHL (n = 254 patients). Overall lymphoma response rate through AVT was 73% [95%>confidence interval, (CI) 67-78%]. Throughout studies there was a strong association between SVR and lymphoma response (83% response rate, 95%>CI, 76-88%) compared to a failure in achieving SVR (53% response rate, 95%>CI, 39-67%, P = 0.0002). There was a trend towards favourable response for AVT in HCV-associated marginal zone lymphomas (response rate 81%, 95%>CI, 74-87%) compared to nonmarginal zone origin (response rate 71%, 95%>CI, 61-79%, P = 0.07). In conclusion, in the current meta-analysis, the overall response rate of HCV-NHL under AVT justifies the recommendation for AVT as first-line treatment in patients who do not need immediate conventional treatment. The strong correlation of SVR and lymphoma regression supports the hypothesis of a causal relationship of HCV and lymphomagenesis.

  11. Tectonic role of margin-parallel and margin-transverse faults during oblique subduction in the Southern Volcanic Zone of the Andes: Insights from Boundary Element Modeling

    Science.gov (United States)

    Stanton-Yonge, A.; Griffith, W. A.; Cembrano, J.; St. Julien, R.; Iturrieta, P.

    2016-09-01

    Obliquely convergent subduction margins develop trench-parallel faults shaping the regional architecture of orogenic belts and partitioning intraplate deformation. However, transverse faults also are common along most orogenic belts and have been largely neglected in slip partitioning analysis. Here we constrain the sense of slip and slip rates of differently oriented faults to assess whether and how transverse faults accommodate plate-margin slip arising from oblique subduction. We implement a forward 3-D boundary element method model of subduction at the Chilean margin evaluating the elastic response of intra-arc faults during different stages of the Andean subduction seismic cycle (SSC). Our model results show that the margin-parallel, NNE striking Liquiñe-Ofqui Fault System accommodates dextral-reverse slip during the interseismic period of the SSC, with oblique slip rates ranging between 1 and 7 mm/yr. NW striking faults exhibit sinistral-reverse slip during the interseismic phase of the SSC, displaying a maximum oblique slip of 1.4 mm/yr. ENE striking faults display dextral strike slip, with a slip rate of 0.85 mm/yr. During the SSC coseismic phase, all modeled faults switch their kinematics: NE striking fault become sinistral, whereas NW striking faults are normal dextral. Because coseismic tensile stress changes on NW faults reach 0.6 MPa at 10-15 km depth, it is likely that they can serve as transient magma pathways during this phase of the SSC. Our model challenges the existing paradigm wherein only margin-parallel faults account for slip partitioning: transverse faults are also capable of accommodating a significant amount of plate-boundary slip arising from oblique convergence.

  12. Marginal Ice Zone Bibliography.

    Science.gov (United States)

    1985-06-01

    In Russian.) Kryndin, A.N., 1971: Seasonal and yearly variations in the iciness and the position of ice edge in the Black and Azov Seas, which are...p.2057--2063. idreas, E.L., R.M. Williams, C.A. Paulson, 1981: Observatinis of conden- sate profiles over Arctic leads with a hot- film anemometer...A.N., 1971: Seasonal and yearly variations in the iciness and the position of ice edge in the Black and Azov Seas, which are associated with

  13. Bilateral Lacrimal Gland Lymphoma in Sjögren Syndrome

    Science.gov (United States)

    Ozsan, Nazan; Sahin, Fahri

    2016-01-01

    A 31-year-old female with Primary Sjögren Syndrome (pSS) presented with bilateral puffiness around the eye for 3 years. The lacrimal glands were hypertrophic and edematous bilaterally. Schirmer 1 score was 2 and 1 mm and tear-film break-up time was 3 and 4 seconds, in the right and the left eyes, respectively. An incisional biopsy from the left lacrimal gland revealed diffuse and intense CD20, CD5, and bcl-2 positivity with negative cyclin D1 and CD23 which supported lymphoma. Upon haematology consultation extranodal marginal zone lymphoma diagnosis was made. CHOP (cyclophosphamide, doxorubicin, vincristine, and methyl prednisolone) treatment was initiated. In conclusion, pSS is a well known autoimmune disease in which increased rate of lymphoma is present. Early detection with histopathologic confirmation and multidisciplinary approach with ophthalmology, rheumatology, and haematology are mandatory in these patients.

  14. Bilateral Lacrimal Gland Lymphoma in Sjögren Syndrome

    Directory of Open Access Journals (Sweden)

    Melis Palamar

    2016-01-01

    Full Text Available A 31-year-old female with Primary Sjögren Syndrome (pSS presented with bilateral puffiness around the eye for 3 years. The lacrimal glands were hypertrophic and edematous bilaterally. Schirmer 1 score was 2 and 1 mm and tear-film break-up time was 3 and 4 seconds, in the right and the left eyes, respectively. An incisional biopsy from the left lacrimal gland revealed diffuse and intense CD20, CD5, and bcl-2 positivity with negative cyclin D1 and CD23 which supported lymphoma. Upon haematology consultation extranodal marginal zone lymphoma diagnosis was made. CHOP (cyclophosphamide, doxorubicin, vincristine, and methyl prednisolone treatment was initiated. In conclusion, pSS is a well known autoimmune disease in which increased rate of lymphoma is present. Early detection with histopathologic confirmation and multidisciplinary approach with ophthalmology, rheumatology, and haematology are mandatory in these patients.

  15. On Impacts of Ocean Waves in Marginal Ice Zones and their Repercussions for Arctic Ice/Ocean Models (Invited)

    Science.gov (United States)

    Squire, V. A.

    2013-12-01

    , each with possibly different concentrations and randomized floes present in some FSD, the manner in which a long crested sea with its intrinsic directional spread advances through a conglomeration of dispersed multiply-scattering floes can be tracked, with the purpose of finding how the waves diminish in amplitude and whether the sea ice will be broken up. The details of how this is done are the subject of another AGU paper. My presentation will focus primarily on the ';why and how' of implanting wave-ice interactions in ice/ocean models and on recent developments to ensure that the physics used is as robust as practicable. Francis, O. P., G. G. Panteleev, and D. E. Atkinson (2011), Ocean wave conditions in the Chukchi Sea from satellite and in situ observations, Geophys. Res. Lett., 38, L24610, doi: 10.1029/ 2011GL049839. Williams, T. D., L. G. Bennetts, V. A. Squire, D. Dumont, and L. Bertino (2013a), Wave-ice interactions in the marginal ice zone. Part 1: Theoretical foundations, Ocean Model., doi: 10.1016/j.ocemod. 2013.05.010. ------ (2013b), Wave-ice interactions in the marginal ice zone. Part 2: Numerical implementation and sensitivity studies along 1D transects of the ocean surface, Ocean Model., doi: 10.1016/j.ocemod. 2013.05.011.

  16. Activity-dependent endogenous taurine release facilitates excitatory neurotransmission in the neocortical marginal zone of neonatal rats.

    Science.gov (United States)

    Qian, Taizhe; Chen, Rongqing; Nakamura, Masato; Furukawa, Tomonori; Kumada, Tatsuro; Akita, Tenpei; Kilb, Werner; Luhmann, Heiko J; Nakahara, Daiichiro; Fukuda, Atsuo

    2014-01-01

    In the developing cerebral cortex, the marginal zone (MZ), consisting of early-generated neurons such as Cajal-Retzius cells, plays an important role in cell migration and lamination. There is accumulating evidence of widespread excitatory neurotransmission mediated by γ-aminobutyric acid (GABA) in the MZ. Cajal-Retzius cells express not only GABAA receptors but also α2/β subunits of glycine receptors, and exhibit glycine receptor-mediated depolarization due to high [Cl(-)]i. However, the physiological roles of glycine receptors and their endogenous agonists during neurotransmission in the MZ are yet to be elucidated. To address this question, we performed optical imaging from the MZ using the voltage-sensitive dye JPW1114 on tangential neocortical slices of neonatal rats. A single electrical stimulus evoked an action-potential-dependent optical signal that spread radially over the MZ. The amplitude of the signal was not affected by glutamate receptor blockers, but was suppressed by either GABAA or glycine receptor antagonists. Combined application of both antagonists nearly abolished the signal. Inhibition of Na(+), K(+)-2Cl(-) cotransporter by 20 µM bumetanide reduced the signal, indicating that this transporter contributes to excitation. Analysis of the interstitial fluid obtained by microdialysis from tangential neocortical slices with high-performance liquid chromatography revealed that GABA and taurine, but not glycine or glutamate, were released in the MZ in response to the electrical stimulation. The ambient release of taurine was reduced by the addition of a voltage-sensitive Na(+) channel blocker. Immunohistochemistry and immunoelectron microscopy indicated that taurine was stored both in Cajal-Retzius and non-Cajal-Retzius cells in the MZ, but was not localized in presynaptic structures. Our results suggest that activity-dependent non-synaptic release of endogenous taurine facilitates excitatory neurotransmission through activation of glycine

  17. Targeting of Ly9 (CD229) Disrupts Marginal Zone and B1 B Cell Homeostasis and Antibody Responses.

    Science.gov (United States)

    Cuenca, Marta; Romero, Xavier; Sintes, Jordi; Terhorst, Cox; Engel, Pablo

    2016-01-15

    Marginal zone (MZ) and B1 B cells have the capacity to respond to foreign Ags more rapidly than conventional B cells, providing early immune responses to blood-borne pathogens. Ly9 (CD229, SLAMF3), a member of the signaling lymphocytic activation molecule family receptors, has been implicated in the development and function of innate T lymphocytes. In this article, we provide evidence that in Ly9-deficient mice splenic transitional 1, MZ, and B1a B cells are markedly expanded, whereas development of B lymphocytes in bone marrow is unaltered. Consistent with an increased number of these B cell subsets, we detected elevated levels of IgG3 natural Abs and a striking increase of T-independent type II Abs after immunization with 2,4,6-trinitrophenyl-Ficoll in the serum of Ly9-deficient mice. The notion that Ly9 could be a negative regulator of innate-like B cell responses was supported by the observation that administering an mAb directed against Ly9 to wild-type mice selectively eliminated splenic MZ B cells and significantly reduced the numbers of B1 and transitional 1 B cells. In addition, Ly9 mAb dramatically diminished in vivo humoral responses and caused a selective downregulation of the CD19/CD21/CD81 complex on B cells and concomitantly an impaired B cell survival and activation in an Fc-independent manner. We conclude that altered signaling caused by the absence of Ly9 or induced by anti-Ly9 may negatively regulate development and function of innate-like B cells by modulating B cell activation thresholds. The results suggest that Ly9 could serve as a novel target for the treatment of B cell-related diseases.

  18. Bruton's Tyrosine Kinase Synergizes with Notch2 to Govern Marginal Zone B Cells in Nonobese Diabetic Mice1,2

    Science.gov (United States)

    Nyhoff, Lindsay E.; Steinberg, Hannah E.; Sullivan, Allison M.; Kendall, Peggy L.

    2015-01-01

    Expansion of autoimmune-prone marginal zone (MZ) B cells has been implicated in type 1 diabetes (T1D). To test disease contributions of MZ B cells in NOD mice, Notch2 haploinsufficiency (Notch2+/−) was introduced, but failed to eliminate the MZ, as it does in C57BL/6 mice. Notch2+/−/NOD have MZ B cell numbers similar to WT C57BL/6, yet still develop diabetes. To test whether BCR-signaling supports Notch2+/−/NOD MZ B cells, Bruton's tyrosine kinase (Btk)-deficiency was introduced. Surprisingly, MZ B cells failed to develop in Btk-deficient Notch2+/−/NOD mice. Expression of Notch2 and its transcriptional target, Hes5, were increased in NOD MZ B cells compared with C57BL/6 MZ B cells. Btk-deficiency reduced Notch2+/− signaling exclusively in NOD B cells, suggesting that BCR-signaling enhances Notch2 signaling in this autoimmune model. The role of BCR-signaling was further investigated using an anti-insulin transgenic BCR (125Tg). Anti-insulin B cells in 125Tg/Notch2+/−/NOD mice populate an enlarged MZ, suggesting that low level BCR signaling overcomes reliance on Notch2. Tracking clonotypes of anti-insulin B cells in H chain only VH125Tg/NOD mice showed that BTK-dependent selection into the MZ depends on strength of antigenic binding, while Notch2-mediated selection does not. Importantly, anti-insulin B cell numbers were reduced by Btk-deficiency, but not Notch2-haploinsufficiency. These studies show that: 1) Notch2-haploinsufficiency limits NOD MZ B cell expansion without preventing T1D, 2) BTK supports the Notch2 pathway in NOD MZ B cells, and 3) autoreactive NOD B cell survival relies on BTK more than Notch2, regardless of MZ location, which may have important implications for disease-intervention strategies. PMID:26034172

  19. Bruton's Tyrosine Kinase Synergizes with Notch2 To Govern Marginal Zone B Cells in Nonobese Diabetic Mice.

    Science.gov (United States)

    Case, James B; Bonami, Rachel H; Nyhoff, Lindsay E; Steinberg, Hannah E; Sullivan, Allison M; Kendall, Peggy L

    2015-07-01

    Expansion of autoimmune-prone marginal zone (MZ) B cells has been implicated in type 1 diabetes. To test disease contributions of MZ B cells in NOD mice, Notch2 haploinsufficiency (Notch2(+/-)) was introduced but failed to eliminate the MZ, as it does in C57BL/6 mice. Notch2(+/-)/NOD have MZ B cell numbers similar to those of wild-type C57BL/6, yet still develop diabetes. To test whether BCR signaling supports Notch2(+/-)/NOD MZ B cells, Bruton's tyrosine kinase (Btk) deficiency was introduced. Surprisingly, MZ B cells failed to develop in Btk-deficient Notch2(+/-)/NOD mice. Expression of Notch2 and its transcriptional target, Hes5, was increased in NOD MZ B cells compared with C57BL/6 MZ B cells. Btk deficiency reduced Notch2(+/-) signaling exclusively in NOD B cells, suggesting that BCR signaling enhances Notch2 signaling in this autoimmune model. The role of BCR signaling was further investigated using an anti-insulin transgenic (Tg) BCR (125Tg). Anti-insulin B cells in 125Tg/Notch2(+/-)/NOD mice populate an enlarged MZ, suggesting that low-level BCR signaling overcomes reliance on Notch2. Tracking clonotypes of anti-insulin B cells in H chain-only VH125Tg/NOD mice showed that BTK-dependent selection into the MZ depends on strength of antigenic binding, whereas Notch2-mediated selection does not. Importantly, anti-insulin B cell numbers were reduced by Btk deficiency, but not Notch2 haploinsufficiency. These studies show that 1) Notch2 haploinsufficiency limits NOD MZ B cell expansion without preventing type 1 diabetes, 2) BTK supports the Notch2 pathway in NOD MZ B cells, and 3) autoreactive NOD B cell survival relies on BTK more than Notch2, regardless of MZ location, which may have important implications for disease-intervention strategies. Copyright © 2015 by The American Association of Immunologists, Inc.

  20. Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.

    Science.gov (United States)

    Inoue, Takashi; Ogawa, Masaharu; Mikoshiba, Katsuhiko; Aruga, Jun

    2008-04-30

    The formation of the highly organized cortical structure depends on the production and correct placement of the appropriate number and types of neurons. The Zic family of zinc-finger transcription factors plays essential roles in regulating the proliferation and differentiation of neuronal progenitors in the medial forebrain and the cerebellum. Examination of the expression of Zic genes demonstrated that Zic1, Zic2, and Zic3 were expressed by the progenitor cells in the septum and cortical hem, the sites of generation of the Cajal-Retzius (CR) cells. Immunohistochemical studies have revealed that Zic proteins were abundantly expressed in the meningeal cells and that the majority of the CR cells distributed in the medial and dorsal cortex also expressed Zic proteins in the mid-late embryonic and postnatal cortical marginal zones. During embryonic cortical development, Zic1/Zic3 double-mutant and hypomorphic Zic2 mutant mice showed a reduction in the number of CR cells in the rostral cortex, whereas the cell number remained unaffected in the caudal cortex. These mutants also showed mislocalization of the CR cells and cortical lamination defects, resembling the changes noted in type II (cobblestone) lissencephaly, throughout the brain. In the Zic1/3 mutant, reduced proliferation of the meningeal cells was observed before the thinner and disrupted organization of the pial basement membrane (BM) with reduced expression of the BM components and the meningeal cell-derived secretory factor. These defects correlated with the changes in the end feet morphology of the radial glial cells. These findings indicate that the Zic genes play critical roles in cortical development through regulating the proliferation of meningeal cells and the pial BM assembly.

  1. Activity-dependent endogenous taurine release facilitates excitatory neurotransmission in the neocortical marginal zone of neonatal rats

    Directory of Open Access Journals (Sweden)

    Taizhe eQian

    2014-02-01

    Full Text Available In the developing cerebral cortex, the marginal zone (MZ, consisting of early-generated neurons such as Cajal-Retzius cells, plays an important role in cell migration and lamination. There is accumulating evidence of widespread excitatory neurotransmission mediated by γ-aminobutyric acid (GABA in the MZ. Cajal-Retzius cells express not only GABAA receptors but also α2/β subunits of glycine receptors, and exhibit glycine receptor-mediated depolarization due to high [Cl−]i. However, the physiological roles of glycine receptors and their endogenous agonists during neurotransmission in the MZ are yet to be elucidated. To address this question, we performed optical imaging from the MZ using the voltage-sensitive dye JPW1114 on tangential neocortical slices of neonatal rats. A single electrical stimulus evoked an action-potential-dependent optical signal that spread radially over the MZ. The amplitude of the signal was not affected by glutamate receptor blockers, but was suppressed by either GABAA or glycine receptor antagonists. Combined application of both antagonists nearly abolished the signal. Inhibition of Na+, K+-2Cl− cotransporter by 20 µM bumetanide reduced the signal, indicating that this transporter contributes to excitation. Analysis of the interstitial fluid obtained by microdialysis from tangential neocortical slices with high-performance liquid chromatography revealed that GABA and taurine, but not glycine or glutamate, were released in the MZ in response to the electrical stimulation. The ambient release of taurine was reduced by the addition of a voltage-sensitive Na+ channel blocker. Immunohistochemistry and immunoelectron microscopy indicated that taurine was stored both in Cajal-Retzius and non-Cajal-Retzius cells in the MZ, but was not localized in presynaptic structures. Our results suggest that activity-dependent non-synaptic release of endogenous taurine facilitates excitatory neurotransmission through activation of

  2. Pre-existing oblique transfer zones and transfer/transform relationships in continental margins: New insights from the southeastern Gulf of Aden, Socotra Island, Yemen

    Science.gov (United States)

    Bellahsen, N.; Leroy, S.; Autin, J.; Razin, P.; d'Acremont, E.; Sloan, H.; Pik, R.; Ahmed, A.; Khanbari, K.

    2013-11-01

    Transfer zones are ubiquitous features in continental rifts and margins, as are transform faults in oceanic lithosphere. Here, we present a structural study of the Hadibo Transfer Zone (HTZ), located in Socotra Island (Yemen) in the southeastern Gulf of Aden. There, we interpret this continental transfer fault zone to represent a reactivated pre-existing structure. Its trend is oblique to the direction of divergence and it has been active from the early up to the latest stages of rifting. One of the main oceanic fracture zones (FZ), the Hadibo-Sharbithat FZ, is aligned with and appears to be an extension of the HTZ and is probably genetically linked to it. Comparing this setting with observations from other Afro-Arabian rifts as well as with passive margins worldwide, it appears that many continental transfer zones are reactivated pre-existing structures, oblique to divergence. We therefore establish a classification system for oceanic FZ based upon their relationship with syn-rift structures. Type 1 FZ form at syn-rift structures and are late syn-rift to early syn-OCT. Type 2 FZ form during the OCT formation and Type 3 FZ form within the oceanic domain, after the oceanic spreading onset. The latter are controlled by far-field forces, magmatic processes, spreading rates, and oceanic crust rheology.

  3. Factors controlling phytoplankton ice-edge blooms in the marginal ice-zone of the northwestern Weddell Sea during sea ice retreat 1988: field observations and mathematical modelling

    OpenAIRE

    Lancelot, Christiane; Mathot, Sylvie; Veth, Cornelis; de Baar, Hein

    1993-01-01

    The factors controlling phytoplankton bloom development in the marginal ice zone of the northwestern Weddell Sea were investigated during the EPOS (Leg 2) expedition (1988). Measurements were made of physical and chemical processes and biological activities associated with the process of ice-melting and their controlling variables particularly light limitation mediated by vertical stability and ice-cover, trace metal deficiency and grazing pressure. The combined observations and process studi...

  4. Multi-phase tectonic structures in the collision zone of the Kolyma-Omolon microcontinent and the eastern margin of the North Asian craton, Northeastern Russia

    OpenAIRE

    Prokopiev, A. V.; Oxman, V. S.

    2009-01-01

    The sequence of formation of structures is established in the zone of junction of the eastern margin of the North Asian craton and the northeastern flank of the Kolyma-Omolon microcontinent, in the area of bend of the Kolyma structural loop. Detailed structural studies revealed two phases in the formation of Mesozoic structures – an early thrust phase and a late strike-slip phase. Structures formed during each of the phases are described. Thrust structures are represented...

  5. Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases

    DEFF Research Database (Denmark)

    Miletic, Ana V; Anzelon-Mills, Amy N; Mills, David M

    2010-01-01

    results in lethal T cell lymphomas, we find that animals lacking PTEN or SHIP in B cells show no evidence of malignancy. However, concomitant deletion of PTEN and SHIP (bPTEN/SHIP(-/-)) results in spontaneous and lethal mature B cell neoplasms consistent with marginal zone lymphoma or, less frequently......, follicular or centroblastic lymphoma. bPTEN/SHIP(-/-) B cells exhibit enhanced survival and express more MCL1 and less Bim. These cells also express low amounts of p27(kip1) and high amounts of cyclin D3 and thus appear poised to undergo proliferative expansion. Unlike normal B cells, bPTEN/SHIP(-/-) B cells...... proliferate to the prosurvival factor B cell activating factor (BAFF). Interestingly, although BAFF availability may promote lymphoma progression, we demonstrate that BAFF is not required for the expansion of transferred bPTEN/SHIP(-/-) B cells. This study reveals that PTEN and SHIP act cooperatively...

  6. Late Holocene and modern glacier changes in the marginal zone of Sólheimajökull, South Iceland

    DEFF Research Database (Denmark)

    Schomacker, Anders; Benediktsson, Ívar Örn; Ingólfsson, Ólafur

    2012-01-01

    , and more restricted advances during the Little Ice Age, after AD 1539. Oscillations of the Sólheimajökull ice margin between 1938 and 2010 are documented by aerial photographs. Digital elevation models were produced from selected years in order to quantify ice thickness changes at the glacier margin over...

  7. Shyok Suture Zone, N Pakistan: late Mesozoic Tertiary evolution of a critical suture separating the oceanic Ladakh Arc from the Asian continental margin

    Science.gov (United States)

    Robertson, Alastair H. F.; Collins, Alan S.

    2002-02-01

    The Shyok Suture Zone (Northern Suture) of North Pakistan is an important Cretaceous-Tertiary suture separating the Asian continent (Karakoram) from the Cretaceous Kohistan-Ladakh oceanic arc to the south. In previously published interpretations, the Shyok Suture Zone marks either the site of subduction of a wide Tethyan ocean, or represents an Early Cretaceous intra-continental marginal basin along the southern margin of Asia. To shed light on alternative hypotheses, a sedimentological, structural and igneous geochemical study was made of a well-exposed traverse in North Pakistan, in the Skardu area (Baltistan). To the south of the Shyok Suture Zone in this area is the Ladakh Arc and its Late Cretaceous, mainly volcanogenic, sedimentary cover (Burje-La Formation). The Shyok Suture Zone extends northwards (ca. 30 km) to the late Tertiary Main Karakoram Thrust that transported Asian, mainly high-grade metamorphic rocks southwards over the suture zone. The Shyok Suture Zone is dominated by four contrasting units separated by thrusts, as follows: (1). The lowermost, Askore amphibolite, is mainly amphibolite facies meta-basites and turbiditic meta-sediments interpreted as early marginal basin rift products, or trapped Tethyan oceanic crust, metamorphosed during later arc rifting. (2). The overlying Pakora Formation is a very thick (ca. 7 km in outcrop) succession of greenschist facies volcaniclastic sandstones, redeposited limestones and subordinate basaltic-andesitic extrusives and flow breccias of at least partly Early Cretaceous age. The Pakora Formation lacks terrigenous continental detritus and is interpreted as a proximal base-of-slope apron related to rifting of the oceanic Ladakh Arc; (3). The Tectonic Melange (Nanga Parbat syntaxis (Hunza River) reveals notable differences, including the presence of terrigenous quartz-rich conglomerates, serpentinite debris-flow deposits and a contrasting structural history. The Shyok Suture Zone in the Skardu area is

  8. Correlation of {sup 18}F-FDG PET/CT and Endoscopic Findings of Twin Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma of the Stomach: Report of a Case

    Energy Technology Data Exchange (ETDEWEB)

    Bahk, Yong Whee; Choi, Jin Wook [SungAe Hospital, Seoul (Korea, Republic of)

    2008-02-15

    Mucosa-associated lymphoid tissue (MALT) type lymphoma arises from extranodal marginal zone B-cell. It is etiologically associated with Helicobacter pylori infection and, hence, can be cured by antibiotic treatment. MALT type lymphoma is the most common variety of gastric lymphoma that is rare in the stomach). The published data of clinical studies on the usefulness of 18F-FDG PET in the diagnosis of MALT type lymphoma varied according to authors. Thus, the result of Hoffmann et al. was discouraging whereas a high diagnostic accuracy was reported by Ambrosini et al. The latter group further went to suggest that higher 18F-FDG uptake in gastric MALT type lymphoma would positively relate to the aggressiveness of neoplasm. The clinical studies conducted by other groups on MALT lymphomas of the stomach, lung, orbit and parotid gland and the stomach, lung, parotid gland, skin, orbit, mandible, esophagus and uterus confirmed that 18F-FDG scan is valuable.

  9. In Situ Hepatitis C NS3 Protein Detection Is Associated with High Grade Features in Hepatitis C-Associated B-Cell Non-Hodgkin Lymphomas

    Science.gov (United States)

    Rabiega, Pascaline; Molina, Thierry J.; Charlotte, Frédéric; Lazure, Thierry; Davi, Frédéric; Settegrana, Catherine; Berger, Françoise; Alric, Laurent; Cacoub, Patrice; Terrier, Benjamin; Suarez, Felipe; Sibon, David; Dupuis, Jehan; Feray, Cyrille; Tilly, Hervé; Pol, Stanislas; Deau Fischer, Bénédicte; Roulland, Sandrine; Thieblemont, Catherine; Leblond, Véronique; Carrat, Fabrice; Hermine, Olivier; Besson, Caroline

    2016-01-01

    Hepatitis C Virus (HCV) infection is associated with the B-cell non-Hodgkin lymphomas (NHL), preferentially marginal zone lymphomas (MZL) and diffuse large B-cell lymphomas (DLBCL). While chronic antigenic stimulation is a main determinant of lymphomagenesis in marginal zone lymphomas (MZL), a putative role of HCV infection of B-cells is supported by in vitro studies. We performed a pathological study within the "ANRS HC-13 LymphoC" observational study focusing on in situ expression of the oncogenic HCV non structural 3 (NS3) protein. Lympho-C study enrolled 116 HCV-positive patients with B-NHL of which 86 histological samples were collected for centralized review. Main histological subtypes were DLBCL (36%) and MZL (34%). Almost half of DLBCL (12/26) were transformed from underlying small B-cell lymphomas. NS3 immunostaining was found positive in 17 of 37 tested samples (46%). There was a striking association between NS3 detection and presence of high grade lymphoma features: 12 out of 14 DLBCL were NS3+ compared to only 4 out of 14 MZL (p = 0.006). Moreover, 2 among the 4 NS3+ MZL were enriched in large cells. Remarkably, this study supports a new mechanism of transformation with a direct oncogenic role of HCV proteins in the occurrence of high-grade B lymphomas. PMID:27257992

  10. Mianlüe tectonic zone and Mianlüe suture zone on southern margin of Qinling-Dabie orogenic belt

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    The Mianlue tectonic zone (Mianlue zone), an ancient suture zone in addition to theShangdan suture in the Qinling-Dabie orogenic belt, marks an important tectonic division geo-logically separating north from south and connecting east with west in China continent. To de-termine present structural geometry and kinematics in the Mianlue tectonic zone and to recon-struct the formation and evolution history involving plate subduction and collision in theQinling-Dabie orogenic belt, through a multidisciplinary study, are significant for exploring themountain-building orogenesis of the central orogenic system and the entire process of the majorChinese continental amalgamation during the Indosinian.

  11. Enhancer mutations of Akv murine leukemia virus inhibit the induction of mature B-cell lymphomas and shift disease specificity towards the more differentiated plasma cell stage

    DEFF Research Database (Denmark)

    Sørensen, Karina Dalsgaard; Kunder, Sandra; Quintanilla-Martinez, Leticia;

    2007-01-01

    This study investigates the role of the proviral transcriptional enhancer for B-lymphoma induction by exogenous Akv murine leukemia virus. Infection of newborn inbred NMRI mice with Akv induced 35% plasma cell proliferations (PCPs) (consistent with plasmacytoma), 33% diffuse large B-cell lymphomas...... showed that many of the tumors/cell proliferations induced by each virus were polyclonal. Our results indicate that enhancer mutations weaken the ability of Akv to induce mature B-cell lymphomas prior to the plasma cell stage, whereas development of plasma cell proliferations is less dependent of viral......, 25% follicular B-cell lymphomas and few splenic marginal zone and small B-cell lymphomas. Deleting one copy of the 99-bp proviral enhancer sequence still allowed induction of multiple B-cell tumor types, although PCPs dominated (77%). Additional mutation of binding sites for the glucocorticoid...

  12. Primary B-Cell Mucosa-Associated Lymphoid Tissue Lymphoma of the Hard Palate and Parotid Gland: Report of One Case and Review of the Literature

    Science.gov (United States)

    Yonal-Hindilerden, Ipek; Hindilerden, Fehmi; Arslan, Serkan; Turan-Guzel, Nalan; Dogan, Ibrahim Oner; Nalcaci, Meliha

    2016-01-01

    A 61-year-old woman was admitted to our hospital with an ulcerated palate mass and swelling of the right parotid gland. Incisional biopsy from the hard palate revealed an extranodal marginal zone B-cell lymphoma, also called mucosa-associated lymphoid tissue (MALT) lymphoma. Final diagnosis was MALT lymphoma of the parotid gland with concomitant involvement of an extremely seldom site of involvement: the hard palate. To our knowledge, this report illustrates the first case of MALT lymphoma of the hard palate and parotid gland without an underlying autoimmune disease. Rituximab-based combination regimen (R-CHOP) provided complete remission with total regression of mass lesions at the hard palate and parotid gland. At 44-month follow-up, there is no disease relapse. We adressed the manifestations and management of MALT lymphoma patients with involvement of salivary gland and oral cavity. PMID:27738485

  13. Detailed subglacial topography and drumlins at the marginal zone of Múlajökull outlet glacier, central Iceland: Evidence from low frequency GPR data

    Science.gov (United States)

    Lamsters, Kristaps; Karušs, Jānis; Rečs, Agnis; Běrziņš, Dāvids

    2016-12-01

    New ground penetrating radar (GPR) observations on the Múlajökull surge-type outlet glacier, central Iceland, are presented. Overall 10.5 km of GPR profile lines were recorded parallel to the glacier margin in August, 2015. Detailed GPR investigations combined with high-accuracy GPS measurements allowed to build a high-resolution model of the subglacial topography. We provide new evidence of streamlined ridges beneath Múlajökull's marginal zone interpreted as drumlins and show the location of the upper edge of the drumlin field. This discovery improves understanding of the location, morphology and development of drumlins as other geophysical observations of subglacial bedforms beneath modern outlet glaciers are quite rare. The location of drumlins corresponds with the position of the major sets of crevasses in the digital elevation model (2008) suggesting the presence of additional drumlins beneath such crevasses in the ice-marginal zone. We suggest this semi-circular pattern of crevasses to be formed due to the variable glacier strain rates created by the subglacial topography. Numerous hyperbolic diffractions representing reflections of englacial channels are found in radar profiles suggesting a well-developed channelized drainage system of a surge-type glacier in its quiescence phase. The calculated thinning of the ice surface in the investigated area (0.65 km2) is on average 17.9 m during 2008-2015.

  14. Atypical Epstein-Barr viral genomic structure in lymphoma tissue and lymphoid cell lines.

    Science.gov (United States)

    Tang, Weihua; Fan, Hongxin; Schroeder, Jane; Dunphy, Cherie H; Bryant, Ronald J; Fedoriw, Yuri; Gulley, Margaret L

    2013-06-01

    Epstein-Barr virus (EBV) DNA is found within the malignant cells of some subtypes of lymphoma, and viral presence is being exploited for improved diagnosis, monitoring, and management of affected patients. Recent work suggests that viral genomic polymorphism, such as partial deletion of the viral genome, could interfere with virus detection in tumor tissues. To test for atypical forms of the EBV genome, 98 lymphomas and 6 infected cell lines were studied using a battery of 6 quantitative polymerase chain reaction assays targeting disparate sections of EBV DNA. Fifty of the lymphomas (51%) had no amplifiable EBV DNA, and 38 lymphomas (39%) had low-level EBV infection that was deemed incidental based on EBV-encoded RNA (EBER) in situ hybridization results. The remaining 10 lymphomas (10%) had high EBV loads and EBER localization to malignant cells by EBER in situ hybridization. All 10 represented lymphoma subtypes were previously associated with EBV (Burkitt, diffuse large B-cell, or T-cell type), whereas no remnants of EBV were detected in other lymphoma subtypes (follicular, small lymphocytic, mantle cell, or marginal zone type). Interestingly, 4 of the 10 infected lymphomas had evidence of atypical viral genomes, including 3 of 4 infected T-cell lymphomas with aberrant loss of LMP2 amplicons, and a single diffuse large B-cell lymphoma lacking the central part of the viral genome spanning BamH1W, BZLF1, and EBNA1 gene segments. A reasonable screening strategy for infected malignancy involves applying EBER1 and LMP1 quantitative polymerase chain reaction assays and confirming that values exceeding 2000 copies of EBV per 100,000 cells have EBER localization to malignant cells.

  15. Study of Safety,Efficacy and Pharmacokinetics of CT-1530 in Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, and Waldenstrom's Macroglobulinemia

    Science.gov (United States)

    2016-12-01

    Relapsed or Refractory B Cell Non-Hodgkin Lymphoma; Chronic Lymphocytic Leukemia; Waldenstrom's Macroglobulinemia; Mantle Zone Lymphoma Refractory/Recurrent; Follicle Centre Lymphoma Diffuse; Diffuse Large B Cell Lymphoma

  16. Nuclear overexpression of lymphoid-enhancer-binding factor 1 identifies chronic lymphocytic leukemia/small lymphocytic lymphoma in small B-cell lymphomas.

    Science.gov (United States)

    Tandon, Bevan; Peterson, Loann; Gao, Juehua; Nelson, Beverly; Ma, Shuo; Rosen, Steven; Chen, Yi-Hua

    2011-11-01

    Lymphoid-enhancer-binding factor 1 (LEF1), coupling with β-catenin, functions as a key nuclear mediator of WNT/β-catenin signaling, which regulates cell proliferation and survival. LEF1 has an important role in lymphopoiesis, and is normally expressed in T and pro-B cells but not mature B cells. However, gene expression profiling demonstrates overexpression of LEF1 in chronic lymphocytic leukemia, and knockdown of LEF1 decreases the survival of the leukemic cells. So far, the data on LEF1 expression in B-cell lymphomas are limited. This study represents the first attempt to assess LEF1 by immunohistochemistry in a large series (290 cases) of B-cell lymphomas. Strong nuclear staining of LEF1 was observed in virtually all neoplastic cells in 92 of 92 (100%) chronic lymphocytic leukemia/small lymphocytic lymphomas including two CD5- cases, with strongest staining in cells with Richter's transformation. LEF1 also highlighted the morphologically inconspicuous small lymphocytic lymphoma component in three composite lymphomas. All 53 mantle cell lymphomas, 31 low-grade follicular lymphomas and 31 marginal zone lymphomas, including 3 CD5+ cases, were negative. In 12 grade 3 follicular lymphomas, LEF1 was positive in a small subset (5-15%) of cells. Diffuse large B-cell lymphoma, however, demonstrated significant variability in LEF1 expression with overall positivity in 27 of 71 (38%) cases. Our results demonstrate that nuclear overexpression of LEF1 is highly associated with chronic lymphocytic leukemia/small lymphocytic lymphoma, and may serve as a convenient marker for differential diagnosis of small B-cell lymphomas. The expression of β-catenin, the coactivator of LEF1 in WNT signaling, was examined in 50 chronic lymphocytic leukemia/small lymphocytic lymphomas, of which 44 (88%) showed negative nuclear staining. The findings of universal nuclear overexpression of LEF1 but lack of nuclear β-catenin in the majority of chronic lymphocytic leukemia/small lymphocytic

  17. Origin of a crustal splay fault and its relation to the seismogenic zone and underplating at the erosional north Ecuador-south Colombia oceanic margin

    Science.gov (United States)

    Collot, J.-Y.; Agudelo, W.; Ribodetti, A.; Marcaillou, B.

    2008-12-01

    Splay faults within accretionary complexes are commonly associated with the updip limit of the seismogenic zone. Prestack depth migration of a multichannel seismic line across the north Ecuador-south Colombia oceanic margin images a crustal splay fault that correlates with the seaward limit of the rupture zone of the 1958 (Mw 7.7) tsunamogenic subduction earthquake. The splay fault separates 5-6.6 km/s velocity, inner wedge basement rocks, which belong to the accreted Gorgona oceanic terrane, from 4 to 5 km/s velocity outer wedge rocks. The outer wedge is dominated by basal tectonic erosion. Despite a 3-km-thick trench fill, subduction of 2-km-high seamount prevented tectonic accretion and promotes basal tectonic erosion. The low-velocity and poorly reflective subduction channel that underlies the outer wedge is associated with the aseismic, décollement thrust. Subduction channel fluids are expected to migrate upward along splay faults and alter outer wedge rocks. Conversely, duplexes are interpreted to form from and above subducting sediment, at ˜14- to 15-km depths between the overlapping seismogenic part of the splay fault and the underlying aseismic décollement. Coeval basal erosion of the outer wedge and underplating beneath the apex of inner wedge control the margin mass budget, which comes out negative. Intraoceanic basement fossil listric normal faults and a rift zone inverted in a flower structure reflect the evolution of the Gorgona terrane from Cretaceous extension to likely Eocene oblique compression. The splay faults could have resulted from tectonic inversion of listric normal faults, thus showing how inherited structures may promote fluid flow across margin basement and control seismogenesis.

  18. Role of Variscan tectonics inheritance in the Jurassic rifting of the passive margin of Adria: insights from the Canavese Zone (Western Southern Alps, Italy)

    Science.gov (United States)

    De Caroli, Sara; Succo, Andrea; Centelli, Arianna; Barbero, Edoardo; Borghi, Alessandro; Balestro, Gianni; Festa, Andrea

    2017-04-01

    The formation of rifted continental margins by extension of continental lithosphere leading to seafloor spreading is a complex component of the plate tectonic cycle. Geological mapping, supported by multidisciplinary analyses of rifted continental margins may thus provide significant information to better understand and model the related processes, and explain the geometry of those margins as observed by means of seismic imaging. We present here our new findings on the Canavese Zone (Italian Western Alps), which is inferred to represent the remnant of the Jurassic syn-rift stretching, thinning and dismemberment of the distal passive margin of Adria, occurred during the opening of the Northern Alpine Tethys. Through multiscale and multidisciplinary, field- and laboratory-based structural, stratigraphic and petrographic studies (from geological map scale to mesoscale and microscope scale), we document that the tectonic dismemberment of the rifted continental margin of Adria did not simply result from the syn-rift Jurassic extension, but was strongly favored by the inheritance of older (Variscan and post-Variscan) tectonic stages, which controlled earlier lithospheric weakness. Our findings show the existence of two different tectonic units of the pre-Variscan basement, which were deformed, juxtaposed and exhumed already during the Variscan orogeny as constraint by (i) intrusion of early Permian granitoids, (ii) emplacement of volcanic rocks and (iii) unconformable overlie of Permian deposits on those metamorphic units. The syn-extensional (syn-rift) Jurassic faults, which affect the Mesozoic sedimentary succession, show only limited vertical displacement that was ineffective in producing and justifying the crustal thinning observed in pre-Variscan basement units. Finally, Late Cretaceous-Early Paleocene and Late Cenozoic strike-slip faulting (i.e. Alpine and Insubric tectonic stages) reactivated previously formed faults, leading to the formation of a complex tectonic

  19. Sedimentary pigments and nature of organic matter within the oxygen minimum zone (OMZ) of the Eastern Arabian Sea (Indian margin)

    Digital Repository Service at National Institute of Oceanography (India)

    Rasiq, K.T.; Kurian, S.; Karapurkar, S.G.; Naqvi, S.W.A.

    Sedimentary pigments, carbon and nitrogen content and their stable isotopes were studied in three short cores collected from the oxygen minimum zone (OMZ) of the Eastern Arabian Sea (EAS). Nine pigments including chlorophyll a and their degradation...

  20. Thermal Structure of the Cascadia Subduction Zone on the Washington Margin (AT26-04, EM122)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — We propose to conduct a comprehensive study of the thermal environment of the Cascadia Subduction Zone (CSZ) within the NSF GeoPRISM Corridor off the Washington...

  1. Evolution of a Western Arctic Ice Ocean Boundary Layer and Mixed Layer Across a Developing Thermodynamically Forced Marginal Ice Zone

    Science.gov (United States)

    2016-09-01

    sufficient buoyancy to the summer halocline to prevent subsequent wind events from mixing out the NSTM. Ice Camp observations captured the development of a... ice zone (MIZ), thermal heterogeneities in the upper ocean led to large ocean-to- ice heat fluxes (100–200 Wm-2) and enhanced basal ice melt (3–6 cm... Ice Zone, turbulent heat flux, heat partitioning; melt pond drainage, through- ice radiative transmission, near- surface temperature maximum, summer

  2. Complete or partial trisomy 3 in gastro-intestinal MALT lymphomas co-occurs with aberrations at 18q21 and correlates with advanced disease stage: A study on 25 cases

    Institute of Scientific and Technical Information of China (English)

    Jens Krugmann; Alexandar Tzankov; Stephan Dirnhofer; Falko Fend; Dominik Wolf; Reiner Siebert; Pensiri Probst; Martin Erdel

    2005-01-01

    @@ TO THE EDITOR Taji et al.[1] have reported in their study on 13 patients with gastric mucosa-associated lymphoid tissue (MALT) lymphomas an aggressive tumor course in trisomy 3 positive cases. The authors analyzed only stage I patients with classical low-grade marginal zone lymphoma of the MALT type and detected the trisomy 3 using an alphasatellite DNA probe directed to the centromere. Their data support the observation that trisomy 3 is the most frequent cytogenetic aberration in MALT lymphomas[2,3].

  3. Thermal regime from bottom simulating reflectors along the N Ecuador - S Colombia margin: relation between tectonic segmentation, thermal variation and the limit of the seismic rupture zones.

    Science.gov (United States)

    Marcaillou, B.; Spence, G.; Collot, J.; Wang, K.; Ribodetti, A.

    2005-12-01

    In the North Ecuador South Columbian (NESC) convergent margin (0°N) three megathrust events, in 1942, 1958 and 1979, present rupture zones that abut one another. Multichannel seismic (MCS) reflection and bathymetric data acquired during the SISTEUR (2000) and AMADEUS (2005) cruises highlighted that the margin comprises four transverse segments (called, from south to north, the Esmeraldas, Manglares, Tumaco and Patia segments), each with clearly different tectonic and structural patterns. The central Manglares and Tumaco segments are separated by the newly discovered NW trending Manglares fault that matches the boundary between the 1958 and 1979 rupture zones. North of the fault, the fore-arc basin is shortened deformed and uplifted, while to the south the fore-arc basin, located landward of a prominent Outer Basement High (OBH), is widely subsiding and undeformed. Moreover, to the north of the Manglares fault, the underthrusting Nazca plate present an intense normal faulting is absent to the south. To investigate the relationships between seismogenesis and thermal structure along the plate boundary, we conducted thermal modelling constrained by sediment heat flow measurements and by heat flow derived from Bottom Simulating Reflectors (BSRs) on MCS lines collected during the SISTEUR and AMADEUS cruises. Just landward of the deformation front in the region of the Tumaco segment, a zone of anomalously low heat flow values is present and results in a thermal segmentation of the margin consistent with the tectonic segmentation. Finite-element thermal models carried out for each thermal segment show that: The along-strike heat flow variations are produced by changes in the age of the oceanic plate, the dip of the decollement and hydrothermal cooling due to the subduction of the strongly faulted part of the Nazca crust. The hypocenters for both the 1958 and 1979 earthquakes occurred at a depth on the interface where the temperature is ~160°C. For the seismogenic zone

  4. Non-Hodgkin lymphoma

    Science.gov (United States)

    Lymphoma - non-Hodgkin; Lymphocytic lymphoma; Histiocytic lymphoma; Lymphoblastic lymphoma; Cancer - non-Hodgkin lymphoma ... National Cancer Institute: PDQ adult non-Hodgkin lymphoma treatment. Bethesda, MD: National Cancer Institute. Updated ... . Accessed ...

  5. Study of channels and margins of milk commercialization at the highlands zone of Sugamuxi providence (Department of Boyacá

    Directory of Open Access Journals (Sweden)

    Paulo Rodríguez Romero

    2005-05-01

    Full Text Available The objective of the present study is to give information about the milk marketing characteristics in Sugamuxi province. The commercialization channels were identified and the commercial agents’ participation margins were established along with the current state of the links that form the production chain. Furthermore, the diffusion and application of the Treaty of Competitiveness of the Milk Sector (ACCL and of its system of prices were evaluated. This analysis discovered problems in two clearly defined areas based on topographical conditions (plain and hillside areas. They each present different problems and use different commercialisation channels. For this reason 235 surveys were given to the different links of the chain in each area. The commercialisation channel in plain areas is: producer, regional processors, wholesaler, consumer, and in hillside areas: producer, transporters, regional processor, local distributor and consumer. The commercialisation margins were calculated for raw milk, pasteurised milk and cheese. Because the profits are greater the great majority of producers in the plain areas are not applying the prices system. Furthermore, there is deficient knowledge of the ACCL on the part of the other links of the chain. Added to the small amount of information about the milk sector and the regional participants the development of a national competitive milk chain is blocked.

  6. Prevalence of Borrelia burgdorferi infection in a series of 98 primary cutaneous lymphomas.

    Science.gov (United States)

    Ponzoni, Maurilio; Ferreri, Andrés J M; Mappa, Silvia; Pasini, Elisa; Govi, Silvia; Facchetti, Fabio; Fanoni, Daniele; Tucci, Alessandra; Vino, Arianna; Doglioni, Claudio; Berti, Emilio; Dolcetti, Riccardo

    2011-01-01

    Borrelia burgdorferi has been variably associated with different forms of primary cutaneous lymphoma. Differences in prevalence rates among reported studies could be a result of geographic variability or heterogeneity in the molecular approaches that have been employed. In the present study, we investigated the prevalence of Borrelia burgdorferi sensu lato DNA in diagnostic tissue samples from fresh cutaneous biopsies of 98 primary cutaneous lymphomas and 19 normal skin controls. Three different polymerase chain reaction (PCR) protocols targeting the hbb, flagellin, and Osp-A genes were used. Direct sequencing of both sense and antisense strands of purified PCR products confirmed the specificity of the amplified fragments. Sequence specificity was assessed using the Basic Local Alignment Search Tool, and MultAlin software was used to investigate the heterogeneity of target gene sequences across the different samples. Borrelia DNA was not detected in 19 controls, 23 cases of follicular lymphoma, 31 cases of extranodal marginal zone lymphoma, or 30 cases of mycosis fungoides. A single case of 14 diffuse large B-cell lymphoma cases was positive for B. burgdorferi. This study does not support a pathogenic role of B. burgdorferi in primary cutaneous B- and T-cell lymphomas from areas nonendemic for this microorganism and the consequent rationale for the adoption of antibiotic therapy in these patients.

  7. Ocular Adnexal Lymphoma Presenting as Refractory Unilateral Open-angle Glaucoma.

    Science.gov (United States)

    Sears, Nathaniel C; Singh, Annapurna; Singh, Arun D

    2016-08-01

    We report a single case of masquerade glaucoma caused by increased episcleral venous pressure from adnexal lymphoma. The patient presented as a referral for unilateral glaucoma with intraocular pressures (IOPs) consistently >40 mm Hg (right eye). We present data conclusively demonstrating extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in the involved eye, and provide an account of the treatment of the tumor with sustained regression and complete resolution of his elevated IOP. We conclude with a discussion of the proposed mechanism. This case serves as a reminder that unilateral open-angle glaucoma can be a sign of indolent ocular adnexal lymphoma. The case also provides a useful model for increased IOP with orbital lesions.

  8. Sjogren syndrome complicated by mucosa-associated lymphoid tissue lymphoma and lymphocytic interstitial pneumonia

    Directory of Open Access Journals (Sweden)

    Fatma eAhmed

    2015-08-01

    Full Text Available Sjogren Syndrome (SS is an autoimmune disease with exocrine glands dysfunction and multiorgan involvement. It is associated with increased risk of lymphoproliferative disorders, especially B-cell marginal zone lymphoma. While the role of F-18 Flurodoxyglucose position emission tomography/CT (F-18 FDG PET/CT for evaluation of lymphoma has been established, its use in patients with a chronic history of SS to evaluate for possible lymphoproliferative disorders or multiorgan involvement is limited. We present a case of chronic SS in which F-18 FDG PET/CT demonstrated FDG avid intraparotid and cervical lymph nodes pathologically proven to be Mucosa-associated lymphoid tissue (MALT lymphoma. In addition, the patient had bibasilar cystic changes consistent with lymphocytic interstitial pneumonia (LIP.

  9. Distribution of Müller stem cells within the neural retina: evidence for the existence of a ciliary margin-like zone in the adult human eye.

    Science.gov (United States)

    Bhatia, Bhairavi; Singhal, Shweta; Lawrence, Jean M; Khaw, Peng T; Limb, G Astrid

    2009-09-01

    Much interest has been generated by the identification of neural stem cells in the human neural retina and ciliary body. However, it is not clear whether stem cells identified in these ocular compartments are of the same origin or whether they ontogenically derive from different cell populations. This study examined the in situ anatomical distribution of these cells within the neural retina and ciliary body, as well as their ability to proliferate in response to EGF. Human retinae and ciliary body were examined for co-expression of Nestin, cellular retinaldehyde binding (CRALBP) or Vimentin, and the stem cell markers SOX2, CHX10, NOTCH1 and SHH. Retinal explants were cultured with epidermal growth factor (EGF) to assess retinal cell proliferation. Intense Nestin and CRALBP staining was observed in the neural retinal margin, where cells formed bundles of spindle cells (resembling glial cells) that lacked lamination and co-stained for SOX2, CHX10 and SHH. This staining differentiated the neural retina from the ciliary epithelium, which expressed SOX2, CHX10 and NOTCH1 but not Nestin or CRALBP. Nestin and CRALBP expression decreased towards the posterior retina, where it anatomically identified a population of Müller glia. All Vimentin positive Müller glia co-stained for SOX2, but only few Vimentin positive cells expressed Nestin and SOX2. Cells of the retinal margin and the inner nuclear layer (INL), where the soma of Müller glia predominate, re-entered the cell cycle upon retinal explant culture with EGF. Lack of lamination and abundance of Müller glia expressing stem cell markers in the marginal region of the adult human retina resemble the ciliary marginal zone (CMZ) of fish and amphibians. The findings that cells in this CM-like zone, as well in the inner nuclear layer proliferate in response to EGF suggest that the adult human retina has regenerative potential. Identification of factors that may promote retinal regeneration in the adult human eye would

  10. Local effects of ice floes and leads on skin sea surface temperature, mixing and gas transfer in the marginal ice zone

    Science.gov (United States)

    Zappa, Christopher; Brumer, Sophia; Brown, Scott; LeBel, Deborah; McGillis, Wade; Schlosser, Peter; Loose, Brice

    2014-05-01

    Recent years have seen extreme changes in the Arctic. Marginal ice zones (MIZ), or areas where the "ice-albedo feedback" driven by solar warming is highest and ice melt is extensive, may provide insights into the extent of these changes. Furthermore, MIZ play a central role in setting the air-sea CO2 balance making them a critical component of the global carbon cycle. Incomplete understanding of how the sea-ice modulates gas fluxes renders it difficult to estimate the carbon budget in MIZ. Here, we investigate the turbulent mechanisms driving gas exchange in leads, polynyas and in the presence of ice floes using both field and laboratory measurements. Here, we present measurements of visible and IR imagery of melting ice floes in the marginal ice zone north of Oliktok Point AK in the Beaufort Sea made during the Marginal Ice Zone Ocean and Ice Observations and Processes EXperiment (MIZOPEX) in July-August 2013. The visible and IR imagery were taken from the unmanned airborne vehicle (UAV) ScanEagle. The visible imagery clearly defines the scale of the ice floes. The IR imagery show distinct cooling of the skin sea surface temperature (SST) as well as an intricate circulation and mixing pattern that depends on the surface current, wind speed, and near-surface vertical temperature/salinity structure. Individual ice floes develop turbulent wakes as they drift and cause transient mixing of an influx of colder surface (fresh) melt water. We capture a melting and mixing event that explains the changing pattern observed in skin SST and is substantiated using laboratory experiments. The Gas Transfer through Polar Sea Ice experiment was performed at the US Army Cold Regions Research and Engineering Laboratory (Hanover, NH) under varying ice coverage, winds speed, fetch and currents. Supporting measurements were made of air and water temperature, humidity, salinity and wave height. Air-side profiling provided momentum, heat, and CO2 fluxes. Transfer velocities are also

  11. Lymphoma of the thyroid gland: a clinicopathologic study over a period of five years in a tertiary care center

    Directory of Open Access Journals (Sweden)

    U. Anjit

    2015-06-01

    Full Text Available Background: Primary Thyroid Lymphoma (PTL is uncommon, accounting for only 5% of thyroid neoplasms and less than 2.5 to 7% of extranodal lymphomas. The study aims to analyze the histopathological findings and to correlate it with clinical features. Methods: This study includes cases of PTL received in the department of pathology in a tertiary care center, Kerala, south India over a period of 5 years. Patient details and follow up data were obtained by communication with treating doctors and reviewing the hospital records. All cases had a minimum follow up of 6 months. Results: 15 cases of PTL were diagnosed over the five year period. In total 72 cases of extranodal lymphomas were diagnosed, thus forming 20.83% of extra nodal lymphomas. Lymphocytic thyroiditis was present in 93.3%. Most of the cases were Extranodal Marginal Zone B Cell Lymphoma (EMZBCL and Diffuse Large B Cell Lymphoma (DLBCL. Conclusion: It is important to consider the diagnosis of primary thyroid lymphoma in patients presenting with an enlarging neck mass especially with the history of Hashimoto's thyroiditis. Random microscopic foci of DLBCL or small areas of MZBL could be overlooked examination or missed with limited sampling. The distinction between MZBL and DLBCL in the thyroid is clinically significant. [Int J Res Med Sci 2015; 3(3.000: 579-582

  12. Orbital lymphoma associated with Graves’ disease: A case report

    Directory of Open Access Journals (Sweden)

    Hajduković Zoran

    2014-01-01

    Full Text Available Introduction. The presence of bilateral exophthalmos and palpebral, periorbital edema associated with hyperthyroidism is most often considered as an initial sign of Graves’ ophthalmopathy. However, in up to 20% of cases, Graves’ ophthalmopathy might precede the occurrence of hyperthyroidism, which is very important to be considered in the differential diagnosis, especially if it is stated as unilateral. Among other less common causes of non-thyroid-related orbitopathy, orbital lymphoma represents rare conditions. We presented of a patient with Graves’ disease, initially manifested as bilateral orbitopathy and progressive unilateral exophthalmos caused by the marginal zone B-cell non-Hodgkin lymphoma of the orbit. Case report. A 64-yearold man with the 3-year history of bilateral Graves’ orbitopathy and hyperthyroidism underwent the left orbital decompression surgery due to the predominantly left, unilateral worsening of exophthalmos resistant to the previously applied glucocorticoid therapy. A year after the surgical treatment, a substantial exophthalmos of the left eye was again observed, signifying that other non-thyroid pathology could be involved. Orbital ultrasound was suggestive of primary orbital lymphoma, what was confirmed by orbital CT scan and the biopsy of the tumor tissue. Detailed examinations indicated that the marginal zone B-cell non-Hodgkin lymphoma extended to IV - B-b CS, IPI 3 (bone marrow infiltration: m+ orbit+. Upon the completion of the polychemiotherapy and the radiation treatment, a complete remission of the disease was achieved. Conclusion. Even when elements clearly indicate the presence of thyroid-related ophthalmopathy, disease deteriorating should raise a suspicion and always lead to imaging procedures to exclude malignancy.

  13. The predictive significance of CD20 expression in B-cell lymphomas

    Directory of Open Access Journals (Sweden)

    Horvat Mateja

    2011-04-01

    Full Text Available Abstract Background In our recent study, we determined the cut-off value of CD20 expression at the level of 25 000 molecules of equivalent soluble fluorochrome (MESF to be the predictor of response to rituximab containing treatment in patients with B-cell lymphomas. In 17.5% of patients, who had the level of CD20 expression below the cut-off value, the response to rituximab containing treatment was significantly worse than in the rest of the patients with the level of CD20 expression above the cut-off value. The proportion of patients with low CD20 expression who might not benefit from rituximab containing treatment was not necessarily representative. Therefore the aim of this study was to quantify the CD20 expression in a larger series of patients with B-cell lymphomas which might allow us to determine more reliably the proportion of patients with the CD20 expression below the cut-off. Methods Cytological samples of 64 diffuse large B-cell lymphomas (DLBCL, 56 follicular lymphomas (FL, 31 chronic lymphocytic leukemias (CLL, 34 mantle cell lymphomas (MCL, 18 marginal zone lymphomas (MZL and 15 B-cell lymphomas unclassified were analyzed for CD20 expression by quantitative four-color flow cytometric measurements using FACSCalibur flow cytometer (BD Biosciences. Results The range of CD20 expression in different B-cell lymphomas was very broad, varying from 2 737 to 115 623 MESF in CLL and 3 549 to 679 577 MESF in DLBCL. However, when we compared the CD20 expression in the groups of patients with DLBCL, FL, MCL, MZL, CLL and B-cell lymphomas unclassified, it was found to be significantly lower (p = 0.002 only in CLL but did not significantly differ in other lymphoma types (p = NS. Fifty-three out of 218 (24.3% patients with B-cell lymphomas had the CD20 expression below the cut-off value. Conclusions The CD20 expression in CLL is significantly lower than in most histological types of mature B-cell lymphomas in which it appears to be comparable

  14. Solvent exposure and malignant lymphoma: a population-based case-control study in Germany

    Directory of Open Access Journals (Sweden)

    Deeg Evelin

    2007-04-01

    Full Text Available Abstract Aims To analyze the relationship between exposure to chlorinated and aromatic organic solvents and malignant lymphoma in a multi-centre, population-based case-control study. Methods Male and female patients with malignant lymphoma (n = 710 between 18 and 80 years of age were prospectively recruited in six study regions in Germany (Ludwigshafen/Upper Palatinate, Heidelberg/Rhine-Neckar-County, Würzburg/Lower Frankonia, Hamburg, Bielefeld/Gütersloh, and Munich. For each newly recruited lymphoma case, a gender, region and age-matched (± 1 year of birth population control was drawn from the population registers. In a structured personal interview, we elicited a complete occupational history, including every occupational period that lasted at least one year. On the basis of job task-specific supplementary questionnaires, a trained occupational physician assessed the exposure to chlorinated hydrocarbons (trichloroethylene, tetrachloroethylene, dichloromethane, carbon tetrachloride and aromatic hydrocarbons (benzene, toluene, xylene, styrene. Odds ratios (OR and 95% confidence intervals (CI were calculated using conditional logistic regression analysis, adjusted for smoking (in pack years and alcohol consumption. To increase the statistical power, patients with specific lymphoma subentities were additionally compared with the entire control group using unconditional logistic regression analysis. Results We observed a statistically significant association between high exposure to chlorinated hydrocarbons and malignant lymphoma (Odds ratio = 2.1; 95% confidence interval 1.1–4.3. In the analysis of lymphoma subentities, a pronounced risk elevation was found for follicular lymphoma and marginal zone lymphoma. When specific substances were considered, the association between trichloroethylene and malignant lymphoma was of borderline statistical significance. Aromatic hydrocarbons were not significantly associated with the lymphoma diagnosis

  15. Layer 6 cortical neurons require Reelin-Dab1 signaling for cellular orientation, Golgi deployment, and directed neurite growth into the marginal zone

    Directory of Open Access Journals (Sweden)

    O’Dell Ryan S

    2012-07-01

    Full Text Available Abstract Background The secreted ligand Reelin is believed to regulate the translocation of prospective layer 6 (L6 neocortical neurons into the preplate, a loose layer of pioneer neurons that overlies the ventricular zone. Recent studies have also suggested that Reelin controls neuronal orientation and polarized dendritic growth during this period of early cortical development. To explicitly characterize and quantify how Reelin controls this critical aspect of neurite initiation and growth we used a new ex utero explant model of early cortical development to selectively label a subset of L6 cortical neurons for complete 3-D reconstruction. Results The total neurite arbor sizes of neurons in Reelin-deficient (reeler mutant and Dab1-deficient (Reelin-non-responsive scrambler mutant cortices were quantified and unexpectedly were not different than control arbor lengths (p = 0.51. For each mutant, however, arbor organization was markedly different: mutant neurons manifested more primary processes (neurites emitted directly from the soma than wild type, and these neurites were longer and displayed less branching. Reeler and scrambler mutant neurites extended tangentially rather than radially, and the Golgi apparatus that normally invests the apical neurite was compact in both reeler and scrambler mutants. Mutant cortices also exhibited a neurite “exclusion zone” which was relatively devoid of L6 neuron neurites and extended at least 15 μm beneath the pial surface, an area corresponding to the marginal zone (MZ in the wild type explants. The presence of an exclusion zone was also indicated in the orientation of mutant primary neurite and neuronal somata, which failed to adopt angles within ~20˚ of the radial line to the pial surface. Injection of recombinant Reelin to reeler, but not scrambler, mutant cortices fully rescued soma orientation, Golgi organization, and dendritic projection defects within four hrs. Conclusions These findings

  16. Polymyalgia Rheumatica Revealing a Lymphoma: A Two-Case Report

    Directory of Open Access Journals (Sweden)

    Frank Verhoeven

    2016-01-01

    Full Text Available Introduction. Polymyalgia rheumatica (PMR is one of the most common inflammatory rheumatism types in elderly population. The link between cancer and PMR is a matter of debate. Methods. We report two cases of PMR leading to the diagnosis of lymphoma and the growing interest of PET-TDM in this indication. Results. A 84-year-old man known for idiopathic neutropenia presented an inflammatory arthromyalgia of the limb girdle since one month. Blood exams highlighted the presence of a monoclonal B cell clone. Bone marrow concluded to a B cell lymphoma of the marginal zone. He was successfully treated with 0.3 mg/kg/d of prednisone, and response was sustained after 6 months. A 73-year-old man known for prostatic neoplasia in remission for 5 years presented arthromyalgia of the limb girdle since one month. PET-CT revealed bursitis of the hips and the shoulders, no prostatic cancer recurrence, and a metabolically active iliac lymphadenopathy whose pathologic exam concluded to a low grade follicular lymphoma. He was successfully treated with 0.3 mg/kg/d of prednisone. Conclusion. These observations may imply that lymphoma is sometimes already present when PMR is diagnosed and PET-CT is a useful tool in the initial assessment of PMR to avoid missing neoplasia.

  17. The sequence of moderate-size earthquakes at the junction of the Ligurian basin and the Corsica margin (western Mediterranean): The initiation of an active deformation zone revealed?

    Science.gov (United States)

    Larroque, Christophe; Delouis, Bertrand; Sage, Françoise; Régnier, Marc; Béthoux, Nicole; Courboulex, Françoise; Deschamps, Anne

    2016-04-01

    A new seismically active zone is found in the southern part of the Ligurian basin, 80-km west of Corsica (western Mediterranean). The activity began in February 2011 with a foreshock (ML 4) and a mainshock (ML 5.3) 5 days later, followed by numerous aftershocks. We first analyze the fore- and mainshock in detail. We compare the results obtained using classical methods (linear location in a 1D medium and focal mechanisms from P and S polarities) and new approaches (non-linear location in a 3D medium and waveform modeling for determining the seismic moment and the focal mechanism). Both methods provided similar results for location, depth (in the range of 6-13 km) and focal mechanisms, which reveal reverse faulting with nodal planes oriented N-S and NE-SW. We then locate 27 of the aftershocks in the 3D model and find a 10-km-long NE-SW alignment with a depth between 7 and 16 km. In 2012 and 2013, three other moderate-size events (ML 3.8, 4 and 4.5) occurred and confirm that this zone is still active. The epicentral area is located in the oceanic domain of the Ligurian Basin. From analysis of the bathymetry and high-resolution multi-channel seismic profiles, no morphologic anomaly at surface and no inherited fault in the shallow ~ 4 km depth were imaged, which suggest that no significant deformation occurred in the area since 5 Ma. Thus, the structure(s) activated during the 2011-2013 sequence remain unknown. In light of these results, we point out a notable difference on both sides of the Ligurian Basin: the northern margin, close to the alpine chain, suffered strong earthquakes and large cumulated deformation since 5 Ma, while the southern margin, close to the Corsica-Sardinia continental block, is poorly deformed since 5 Ma.

  18. Enhancer mutations of Akv murine leukemia virus inhibit the induction of mature B-cell lymphomas and shift disease specificity towards the more differentiated plasma cell stage

    DEFF Research Database (Denmark)

    Sørensen, Karina Dalsgaard; Kunder, Sandra; Quintanilla-Martinez, Leticia

    2007-01-01

    This study investigates the role of the proviral transcriptional enhancer for B-lymphoma induction by exogenous Akv murine leukemia virus. Infection of newborn inbred NMRI mice with Akv induced 35% plasma cell proliferations (PCPs) (consistent with plasmacytoma), 33% diffuse large B-cell lymphomas......, 25% follicular B-cell lymphomas and few splenic marginal zone and small B-cell lymphomas. Deleting one copy of the 99-bp proviral enhancer sequence still allowed induction of multiple B-cell tumor types, although PCPs dominated (77%). Additional mutation of binding sites for the glucocorticoid...... receptor, Ets, Runx, or basic helix-loop-helix transcription factors in the proviral U3 region, however, shifted disease induction to almost exclusively PCPs, but had no major influence on tumor latency periods. Southern analysis of immunoglobulin rearrangements and ecotropic provirus integration patterns...

  19. The second species of Gromia (Protista) from the deep sea: its natural history and association with the Pakistan margin oxygen minimum zone.

    Science.gov (United States)

    Gooday, Andrew J; Bowser, Samuel S

    2005-06-01

    We describe a gromiid protist Gromia pyriformis sp. nov., from bathyal depths on the Pakistan margin (NE Arabian Sea), an area characterised by a well-developed Oxygen Minimum Zone (OMZ). The new species is smaller (length usually <1 mm) than the only other described deep-sea gromiid species (Gromia sphaerica) or the well-known coastal species Gromia oviformis. Its identification as a gromiid is based on the test-wall ultrastructure. This includes (i) an outer wall (165-300 nm thick) limited by an electron-opaque layer and perforated by pore structures which typically extend through its entire thickness, and (ii) inner "honeycomb membrane" structures which form a discontinuous sheet (18-20 nm thick) lying parallel to the outer wall. An outermost glycocalyx (approximately 75 nm thick), not observed in other gromiid species, is also present and imparts a finely granular appearance to the outer test surface, as seen by Scanning Electron Microscopy (SEM). Numerous rod-shaped prokaryotes are attached to the exterior of the glycocalyx. Gromia pyriformis sp. nov. typically occurs above the sediment-water interface, attached to the large arborescent foraminiferan Pelosina sp. It is confined to a very narrow bathymetric zone (approximately 1000 m water depth) in the lower portion of the OMZ, where bottom-water oxygen concentrations are approximately 0.2 ml l(-1).

  20. Hodgkin Lymphoma (For Teens)

    Science.gov (United States)

    ... Can I Help Someone Who's Being Bullied? Volunteering Hodgkin Lymphoma KidsHealth > For Teens > Hodgkin Lymphoma Print A ... to check for disease, including lymphoma. What Is Hodgkin Lymphoma? Hodgkin lymphoma is a type of cancer ...

  1. Gastrointestinal lymphomas in a North American population: clinicopathologic features from one major Central-Midwestern United States tertiary care medical center

    Directory of Open Access Journals (Sweden)

    Warrick Joshua

    2012-06-01

    Full Text Available Abstract Background Gastrointestinal (GI lymphomas are very common types of extranodal lymphomas, and we hypothesize there are regional differences in subtype, distribution in the GI tract, and epidemiological features among the different populations. Methods We retrospectively evaluated the clinical, molecular and histologic features of North American primary and secondary GI lymphomas diagnosed from 2000–2009 seen at our institution. We utilized immunohistochemistry and fluorescence in situ hybridization to further evaluate a subset of the gastric lymphomas. Results Extranodal marginal zone lymphomas of mucosal associated lymphoid tissue (MALTs and diffuse large B cell lymphomas (DLBCLs were the most common subtypes of GI lymphomas. Select gastric DLBCLs (N = 6 and MALTs (N = 13 were further examined for API2-MALT1 and IGH translocations, and P16 and P53 protein expression. Gastric MALTs showed frequent API2-MALT1 (38% but not IGH translocations (0%, and the DLBCLs showed neither translocation. Expression of P16 and P53 proteins and the proliferative index were compared between high grade gastric lymphomas (gastric DLBCLs and low grade gastric lymphomas (gastric MALTs. P53 overexpression (P = 0.008 and a high proliferation index [Ki-67] (P = 0.00042 were significantly associated with gastric DLBCL, but no statistically significant difference was observed in P16 expression (p = 0.108 between gastric DLBCL and gastric MALT. Conclusion Our study revealed that GI lymphomas from a Central-Midwestern North American population showed differences and similarities to non-North American cohorts. In addition, API2-MALT1, P16 and P53 abnormalities occurred frequently in gastric lymphomas from this North American population. Virtual slides The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1415505838687793

  2. Immunohistochemical comparison of CD5, lambda, and kappa expression in primary and recurrent buccal mucosa-associated lymphoid tissue (MALT) lymphomas.

    Science.gov (United States)

    Tanaka, Toshiaki; Kitabatake, Kenichirou; Iino, Mituyoshi; Goto, Kaoru

    2011-09-06

    Mucosa-associated lymphoid tissue (MALT) lymphoma is a type of extranodal marginal zone B-cell lymphoma and is a distinct subtype of non-Hodgkin's lymphoma.Primary MALT lymphomas can also occur in the oral cavity, although their appearance in this location is rare. The neoplastic cells of which MALT lymphomas are composed express B-cell antigens and show monotypic immunoglobulin expression with light-chain restriction.Although neoplastic MALT lymphoma cells do not express CD5, previous studies have shown that CD5 positive MALT lymphomas are more prone to dissemination than those that do not express CD5. Moreover, there are some reports that describe kappa- and lambda- dual light chain expression in B cell malignant neoplasms.A 66-year-old Japanese woman with swelling of the right buccal mucosa was referred to our hospital. The lesion was excised and was pathologically diagnosed as a MALT lymphoma tumor with a t(11;18)(q21;q21) chromosome translocation.Swelling of the right buccal mucosa recurred 2 years later. The recurrent tumor was then excised and pathologically diagnosed as MALT lymphoma.Immunohistochemical examination of CD5, lambda, and kappa expressions revealed that the primary tumor was positive for CD5, kappa, and lambda, but the recurrent tumor was weakly positive for CD5 and kappa.With respect to lambda positivity, the recurrent tumor showed negativity.Our study suggests that immunohistochemical expression of CD5, kappa, and lambda in oral MALT lymphoma have the risk of recurrence.We first described the recurrence of CD5 positive MALT lymphoma in the oral cavity and compared the immunohistochemical expressions of CD5, lambda, and kappa between the primary and recurrent tumors.

  3. Does water level affect benthic macro-invertebrates of a marginal lake in a tropical river-reservoir transition zone?

    Science.gov (United States)

    Zerlin, R A; Henry, R

    2014-05-01

    Benthic macro-invertebrates are important components of freshwater ecosystems which are involved in ecological processes such as energy transfer between detritus and consumers and organic matter recycling. The aim of this work was to investigate the variation in organism richness, diversity and density of benthic fauna during the annual cycle in Camargo Lake, a lake marginal to Paranapanema River, southeast Brazil. The correlation of environmental factors with community attributes of the macro-benthic fauna was assessed. Since Camargo Lake is connected to the river, we tested the hypothesis that water level variation is the main regulating factor of environmental variables and of the composition and abundance of benthic macro-invertebrates. The results indicated that lake depth varied with rainfall, being the highest at the end of the rising water period and the lowest at the beginning of this period. The sediment granulometry was more heterogeneous at the bottom of the lake by the end of the high water period. The benthic macro-invertebrate fauna was composed by 15 taxa. The Diptera order was represented by seven taxa and had greater richness in relation to other taxa. This group was responsible for 60% of the total abundance of organisms, followed by Ephemeroptera (22%) and Anellida (16%). Significant differences were observed over time in total richness and, in density of Narapa bonettoi, Chaoborus, Ablabesmyia gr. annulata, Chironomus gigas, Larsia fittkau, and Procladius sp. 2. Total taxa richness correlated negatively with water pH, transparency, conductivity, and bottom water oxygen. Higher positive correlations were found between the densities of some taxa and bottom water oxygen, conductivity and very fine sand, silt + clay of sediment, while negative correlations were recorded with organic matter, and fine, medium and coarse sand, bottom water temperature, mean temperature and rainfall. The significant temporal difference in water level was associated

  4. Fast rates of subduction erosion along the Costa Rica Pacific margin: Implications for nonsteady rates of crustal recycling at subduction zones

    Science.gov (United States)

    Vannucchi, P.; Ranero, C.R.; Galeotti, S.; Straub, S.M.; Scholl, D. W.; McDougall-Ried, K.

    2003-01-01

    At least since the middle Miocene (???16 Ma), subduction erosion has been the dominant process controlling the tectonic evolution of the Pacific margin of Costa Rica. Ocean Drilling Program Site 1042 recovered 16.5 Ma nearshore sediment at ???3.9 km depth, ???7 km landward of the trench axis. The overlying Miocene to Quaternary sediment contains benthic foraminifera documenting margin subsidence from upper bathyal (???200 m) to abyssal (???2000 m) depth. The rate of subsidence was low during the early to middle Miocene but increased sharply in the late Miocene-early Pliocene (5-6.5 Ma) and at the Pliocene-Pleistocene boundary (2.4 Ma). Foraminifera data, bedding dip, and the geometry of slope sediment indicate that tilting of the forearc occurred coincident with the onset of rapid late Miocene subsidence. Seismic images show that normal faulting is widespread across the continental slope; however, extension by faulting only accounts for a minor amount of the post-6.5 Ma subsidence. Basal tectonic erosion is invoked to explain the subsidence. The short-term rate of removal of rock from the forearc is about 107-123 km3 Myr-1 km-1. Mass removal is a nonsteady state process affecting the chemical balance of the arc: the ocean sediment input, with the short-term erosion rate, is a factor of 10 smaller than the eroded mass input. The low 10Be concentration in the volcanic arc of Costa Rica could be explained by dilution with eroded material. The late Miocene onset of rapid subsidence is coeval with the arrival of the Cocos Ridge at the subduction zone. The underthrusting of thick and thermally younger ocean crust decreased the subduction angle of the slab along a large segment of the margin and changed the dynamic equilibrium of the margin taper. This process may have induced the increase in the rate of subduction erosion and thus the recycling of crustal material to the mantle. Copyright 2003 by the American Geophysical Union.

  5. Structural and functional study of the nematode community from the Indian western continental margin with reference to habitat heterogeneity and oxygen minimum zone

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    R. Singh

    2015-07-01

    Full Text Available We studied patterns of nematode distribution along the western Indian continental margin to determine the influence of habitat heterogeneity and oxygen minimum on the community's taxonomic and functional structure. A single transect, perpendicular to the coast at 14° N latitude was sampled from 34 to 2546 m depth for biological and environmental variables during August 2007. Nematodes were identified to species and classified according to biological/functional traits. A total of 110 nematode species belonging to 24 families were found along the transect. Mean nematode density was higher on the shelf (176 ind 10 cm−2, 34 m depth than on the slope (124 ind 10 cm−2 or in the basin 62.9 ind 10 cm−2. Across the entire study area, the dominant species were Terschellingia longicaudata, (15.2 %, Desmodora sp 1, Sphaerolaimus gracilis, and Theristus ensifer; their maximum density was at shelf stations. Multidimensional scaling ordination (nMDS of the nematode species abundance data indicated the effect of different zones (ANOSIM; Global R = 0.607; P = 0.028, but it was not the same in case of functional traits. Only seven species were found exclusively in the oxygen minimum zone: Pselionema sp 1, Choanolaimus sp 2, Halichoanolaimus sp 1, Cobbia dentata, Daptonema sp 1, Trissonchulus sp 1, and Minolaimus sp 1. Moreover, in our study, species diversity was higher on the shelf than on the slope or in the basin. The distinctive features of all three zones as based on nematofaunal abundance were also reflected in the functional traits (feeding types, body shape, tail shape, and life history strategy. Correlation with a number of environmental variables indicated that food quality (measured as the organic carbon content and chlorophyll content and oxygen level were the major factors that influenced the nematode community (structural and functional.

  6. RELATIONSHIP BETWEEN P-T CONTITIONS OF TWO PHASES OF TAN-LU STRIKE-SLIP SHEAR ZONES AND DELAMINATION OF OROGENIC BELTS ON THE EASTERN MARGIN OF THE DABIE MOUNTAINS

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The Tan-Lu fault zone joins the Dabie Mountains on its eastern margin, and offsets the Dabie and Sulu orogenic belts sinistrally for about 500 km. On the basis of calculation of temperature and pressure experienced by the two phases of the fault zone as well as the thermo-chronological information on mylonite from the earlier and later Tan-Lu fault zones on the eastern margin of the Dabie Mountains, this paper discusses the delamination history and uplifting magnitudes of the Dabie Mountains from earlier Jurassic to earlier Cretaceous. From mineral assemblages, mineral deformation and muscovite-chlorite geothermometry calculation, it is known that the temperature experienced by the two phases of Tan-Lu fault zones are between 400℃ and 450℃, and the confining pressures are between 0.25Gpa and 0.36GPa for the earlier shear zones and 0.24-0.39GPa for the late shear zones. According to the geobarometry of Si-in-phengite and by considering shear heating and tectonic over-pressure, it is concluded that the maximum formation depths for the two phases of the ductile shear zones are not more than 12 km.Differential formation depths for the two phases of shear zones are 1-2 km at most. At about 190 Ma and 128 Ma, the Tan-Lu fault zone experienced two phases of cooling events. During this period, the eastern margin of the Dabie Mountains experienced a tectonic calm period and no uplifting. According to information from the Tan-Lu fault zone, the uplifting magnitudes of the Dabie orogenic belts are not more than 12 km during the earlier Cretaceous.

  7. An unusual presentation of gastric mucosa-associated lymphoid tissue (MALT-type lymphoma

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    Bikram Shrestha

    2016-09-01

    Full Text Available Mucosa-associated lymphoid tissue (MALT-type lymphoma is a relatively rare disease; nevertheless, it is the third most common lymphoma type, accounting for 5–7% of all non-Hodgkin lymphomas. Case series and retrospective analysis published in the literature have suggested that extra gastrointestinal (GI MALT-type lymphoma can occur simultaneously with MALT-type lymphoma involving the GI tract. We report the case of a healthy, 64-year-old Caucasian male who presented with progressive fatigue, non-productive cough, and worsening exertional shortness of breath for 3 months who was subsequently diagnosed with gastric extra-nodal marginal zone B-cell lymphoma or MALToma with simultaneous metastasis to the lung (bronchi based on biopsy reports. Case presentation: A 64-year-old Caucasian male presented to the emergency room complaining of progressive fatigue for 3 months which had progressed to the point of hindering his usual activities of daily living (ADL. He had recently visited his primary care provider for evaluation of a non-productive cough and exertional shortness of breath. A chest radiography obtained at the time showed bilateral infiltrates. He was then treated for atypical pneumonia but his symptoms unfortunately did not improve. Initial investigations in the emergency room revealed severe anemia and a positive stool guaiac test. Imaging showed bilateral pulmonary infiltrates and an irregular gastric mass. Gastric and transbronchial biopsies were suggestive of extra-nodal marginal zone B-cell lymphoma with simultaneous metastasis to the bronchi. He was treated symptomatically with transfusion of packed red blood cells (PRBC and intravenous iron followed by radiotherapy. Helicobacter pylori infection was ruled out eliminating the possibility of treating him with eradication therapy. Conclusion: Although the stomach is the most common and most extensively studied site of involvement of MALT lymphomas, they can also emerge in many other

  8. Conjunctival lymphoma arising from reactive lymphoid hyperplasia

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    Fukuhara Junichi

    2012-09-01

    Full Text Available Abstract Extra nodal marginal zone B-cell lymphoma (EMZL of the conjunctiva typically arises in the marginal zone of mucosa-associated lymphoid tissue. The pathogenesis of conjunctival EMZL remains unknown. We describe an unusual case of EMZL arising from reactive lymphoid hyperplasia (RLH of the conjunctiva. A 35-year-old woman had fleshy salmon-pink conjunctival tumors in both eyes, oculus uterque (OU. Specimens from conjunctival tumors in the right eye, oculus dexter (OD, revealed a collection of small lymphoid cells in the stroma. Immunohistochemically, immunoglobulin (Ig light chain restriction was not detected. In contrast, diffuse atypical lymphoid cell infiltration was noted in the left eye, oculus sinister (OS, and positive for CD20, a marker for B cells OS. The tumors were histologically diagnosed as RLH OD, and EMZL OS. PCR analysis detected IgH gene rearrangement in the joining region (JH region OU. After 11 months, a re-biopsy specimen demonstrated EMZL based on compatible pathological and genetic findings OD, arising from RLH. This case suggests that even if the diagnosis of the conjunctival lymphoproliferative lesions is histologically benign, confirmation of the B-cell clonality by checking IgH gene rearrangement should be useful to predict the incidence of malignancy.

  9. Palaeoenvironmental and geochemical approach of Archaeocyath-rich facies from Lower Cambrian of Western Gondwana margin at Central Iberian Zone (Urda, Toledo Mountains, Spain)

    Science.gov (United States)

    Menéndez, Silvia; Rodríguez-Martínez, Marta; Moreno-Eris, Elena; Perejón, Antonio; Reitner, Joachim

    2010-05-01

    Archaeocyath-rich facies are located in a quarry close to Urda village, at Toledo Mountains, Spain. The outcrops belong to the Caliza de los Navalucillos Formation and they record a considerably high diverse archaeocyath assemblage in the Lower Cambrian successions from the Central Iberian Zone (Julivert et al. 1972 [1974]). In fact, it is first time recorded the presence of Agyrekocyathus, Dokidocyathus, and Plicocyathus in the Central Iberian Zone. Therefore Plicocyathus is no longer exclusive to biozone VI in Spain. The presence of Anthomorpha is characteristic for the early Botomian, presently early Stage 4 (ICS, 2009), and the assemblage corresponds to the biozone VII (late Ovetian, following the biozonation of Perejón & Moreno-Eiris, 2006). The fossiliferous part of the succession is formed by seven lithofacies, all of them tectonically folded and with a low grade metamorphic overprint. They are comprised by two main groups of facies: (a) mound-shaped to massive lithofacies (A1, A2, A3, A4) and (b) massive to bedded and nodular lithofacies (B1, B2, B3). Archaeocyaths occur in several facies: (A1) mound-shaped white marble with irregular to stromatactoid cavities; (A2) massive mottled white to grey limestone; (A3) massive grey limestone with slumps levels; (A4) massive archaeocyath-rich orange limestone; as well as in carbonate nodules embedded in siltstones and cherts (B1, B2 and B3). The best preserved assemblage comes from the nodule record, where fossils are partially pyritized. This type of preservation is exceptional and has never been described before. XRD and wavelength-dispersive electron microprobe analyses reveal the presence of pyrite and pyrrotine partially altered to iron oxides and hydroxides (hematite and goethite) surrounding the archaeocyath cups. In Central Iberian Zone, the development of mounds and nodular facies like those described here is unusual, although the Botomian marks the peak for Early Cambrian archaeocyathan-microbial mounds

  10. A shifting rift—Geophysical insights into the evolution of Rio Grande rift margins and the Embudo transfer zone near Taos, New Mexico

    Science.gov (United States)

    Grauch, V.J.S.; Bauer, Paul W.; Drenth, Benjamin J.; Kelson, Keith I.

    2017-01-01

    We present a detailed example of how a subbasin develops adjacent to a transfer zone in the Rio Grande rift. The Embudo transfer zone in the Rio Grande rift is considered one of the classic examples and has been used as the inspiration for several theoretical models. Despite this attention, the history of its development into a major rift structure is poorly known along its northern extent near Taos, New Mexico. Geologic evidence for all but its young rift history is concealed under Quaternary cover. We focus on understanding the pre-Quaternary evidence that is in the subsurface by integrating diverse pieces of geologic and geophysical information. As a result, we present a substantively new understanding of the tectonic configuration and evolution of the northern extent of the Embudo fault and its adjacent subbasin.We integrate geophysical, borehole, and geologic information to interpret the subsurface configuration of the rift margins formed by the Embudo and Sangre de Cristo faults and the geometry of the subbasin within the Taos embayment. Key features interpreted include (1) an imperfect D-shaped subbasin that slopes to the east and southeast, with the deepest point ∼2 km below the valley floor located northwest of Taos at ∼36° 26′N latitude and 105° 37′W longitude; (2) a concealed Embudo fault system that extends as much as 7 km wider than is mapped at the surface, wherein fault strands disrupt or truncate flows of Pliocene Servilleta Basalt and step down into the subbasin with a minimum of 1.8 km of vertical displacement; and (3) a similar, wider than expected (5–7 km) zone of stepped, west-down normal faults associated with the Sangre de Cristo range front fault.From the geophysical interpretations and subsurface models, we infer relations between faulting and flows of Pliocene Servilleta Basalt and older, buried basaltic rocks that, combined with geologic mapping, suggest a revised rift history involving shifts in the locus of fault activity as

  11. A microstructural and argon laserprobe study of shear zone development at the western margin of the Nanga Parbat-Haramosh Massif, western Himalaya

    Science.gov (United States)

    Reddy, Steven M.; Kelley, Simon P.; Magennis, Lochlann

    A sample of banded amphibolite from the western margin of the Nanga Parbat-Haramosh Massif as Sassi has been studied using microstructural and 40Ar/39Ar laserprobe techniques to investigate the relationship between deformation and argon isotope variations in a natural system. Amphibolite-grade deformation occurred during south-directed overthrusting of the Kohistan arc over India along the Main Mantle Thrust and was overprinted by extensional reactivation of the earlier fabric and the formation of biotite-rich shear zones. Subsequent deformation along discrete fine-grained fault zones was characterised by the formation of scapolite, chlorite and K-feldspar, early plastic deformation and later cataclasis. Different minerals developed during this history show a wide range in apparent 40Ar/39Ar ages. Biotite, chlorite and scapolite exhibit much lower concentrations of excess argon, indicating their equilibration in a fluid relatively poor in excess argon. A `true' age of ca. 8 Ma from biotite represents a minimum age for deformation associated with formation of the Nanga Parbat Syntaxis and also precludes Pliocene metamorphism in this area of the syntaxis. Both high- and low-closure temperature minerals (amphiboles and feldspars) record apparent ages which are associated with the incorporation of excess argon within the mineral lattice. Although differential thermal resetting of minerals at different closure temperatures is important, variations in the inherited 40Ar/36Ar ratio throughout the sample is dominated by deformation and fluid infiltration. Consequently it appears that within deforming metamorphic rocks, areas with significantly different argon isotope compositions may be present and need not be homogenised by diffusion.

  12. IODP Expedition 334: An Investigation of the Sedimentary Record, Fluid Flow and State of Stress on Top of the Seismogenic Zone of an Erosive Subduction Margin

    Directory of Open Access Journals (Sweden)

    Paola Vannucchi

    2013-03-01

    Full Text Available The Costa Rica Seismogenesis Project (CRISP is an experiment to understand the processes that control nucleation and seismic rupture of large earthquakes at erosional subduction zones. Integrated Ocean Drililng Program (IODP Expedition 334 by R/V JOIDES Resolution is the first step toward deep drilling through the aseismic and seismicplate boundary at the Costa Rica subduction zone offshore the Osa Peninsula where the Cocos Ridge is subducting beneath the Caribbean plate. Drilling operations included logging while drilling (LWD at two slope sites (Sites U1378 and U1379 and coring at three slope sites (Sites U1378–1380and at one site on the Cocos plate (Site U1381. For the first time the lithology, stratigraphy, and age of the slope and incoming sediments as well as the petrology of the subducting Cocos Ridge have been characterized at this margin.The slope sites recorded a high sediment accumulation rate of 160–1035m m.y.-1 possibly caused by on-land uplift triggered by the subduction of the Cocos Ridge. The geochemical data as well as the in situ temperature data obtained at the slope sites suggest that fluids are transported from greater depths. The geochemical profiles at Site U1381 reflect diffusional communication of a fluid with seawater-likechemistry and the igneous basement of the Cocos plate (Solomon et al., 2011; Vannucchi et al., 2012a. The present-day in situ stress orientation determined by borehole breakouts at Site U1378 in the middle slope and Site U1379 in the upper slope shows a marked change in stress state within ~12 km along the CRISP transect; that maycorrespond to a change from compression (middle slope to extension (upper slope.

  13. Formation processes of sea ice floe size distribution in the interior pack and its relationship to the marginal ice zone off East Antarctica

    Science.gov (United States)

    Toyota, Takenobu; Kohout, Alison; Fraser, Alexander D.

    2016-09-01

    To understand the behavior of the Seasonal Ice Zone (SIZ), which is composed of sea-ice floes of various sizes, knowledge of the floe size distribution (FSD) is important. In particular, FSD in the Marginal Ice Zone (MIZ), controlled by wave-ice interaction, plays an important role in determining the retreating rates of sea-ice extent on a global scale because the cumulative perimeter of floes enhances melting. To improve the understanding of wave-ice interaction and subsequent effects on FSD in the MIZ, FSD measurements were conducted off East Antarctica during the second Sea Ice Physics and Ecosystems eXperiment (SIPEX-2) in late winter 2012. Since logistical reasons limited helicopter operations to two interior ice regions, FSD in the interior ice region was determined using a combination of heli-photos and MODIS satellite visible images. The possible effect of wave-ice interaction in the MIZ was examined by comparison with past results obtained in the same MIZ, with our analysis showing: (1) FSD in the interior ice region is basically scale invariant for both small- (large- (>1 km) scale regimes; (2) although fractal dimensions are quite different between these two regimes, they are both rather close to that in the MIZ; and (3) for floes <100 m in diameter, a regime shift which appeared at 20-40 m in the MIZ is absent. These results indicate that one role of wave-ice interaction is to modulate the FSD that already exists in the interior ice region, rather than directly determine it. The possibilities of floe-floe collisions and storm-induced lead formation are considered as possible formation processes of FSD in the interior pack.

  14. In North Ecuador - South Colombia margin (0-4°N), the sedimentation rate in the trench and the tectonic deformation co-control the location of the seismogenic zone.

    Science.gov (United States)

    Marcaillou, Boris; Jean-Yves, Collot; Allessandra, Ribodetti; Elia, D'acremont

    2010-05-01

    The North Ecuador - South Colombia convergent margin shows along strike variations in tectonic, thermal and seismogenic features that offer a great opportunity to study the relation between subduction zone tectono-structure, thermal regime and location of the thermally-defined seismogenic zone. Multichannel seismic reflections and conventional bathymetric data were collected in 2000 and 2005 during the SISTEUR and AMADEUS cruises. 6 selected lines perpendicular to the margin were processed with a pre-stack depth migration using a preserved amplitude approach (alias Ray+Born diffraction tomography). The first heat flow measurements in this area were also acquired, completed by heat flow derived from numerous bottom simulating reflectors. The margin is divided in Esmeraldas, Patia, Tumaco and Manglares segments. 1/ Tectonically, the tectonic deformation at the margin front drastically vary from North to South: The Patia segment is fronted by a 35 km- long active accretionary prism, the Tumaco segment by a less than 10 km-long active accretionary prism, no accretion occur in the Manglares segment, while the southern Esmeraldas segment undergoes a strong tectonic erosion. It is noteworthy that this regime is independent from the sediment thickness in the trench which is thinner where the prism is longer. 2/ Thermally, these segments also shows clear variations in heat flow that is, in the trench and in the lower slope, two-fold lower in the Tumaco segment than in the others. 3/ Sismogenically, large subduction earthquakes have ruptured the plate interface beneath the Manglares segment in 1958 and the Tumaco-Patia segments en 1979. Based on the aftershocks distribution and the rupture zone location, the seismogenic zone extends trenchward nearby the deformation front in the Patia-Tumaco segments but is restricted 30 km landward in the Manglares segment. The integrated interpretation of heat flow and sismic data indicate that: 1/ The thermal segmentation is mainly

  15. Immunoglobulin gene repertoire in ocular adnexal lymphomas: hints on the nature of the antigenic stimulation.

    Science.gov (United States)

    Dagklis, A; Ponzoni, M; Govi, S; Cangi, M G; Pasini, E; Charlotte, F; Vino, A; Doglioni, C; Davì, F; Lossos, I S; Ntountas, I; Papadaki, T; Dolcetti, R; Ferreri, A J M; Stamatopoulos, K; Ghia, P

    2012-04-01

    Evidence from certain geographical areas links lymphomas of the ocular adnexa marginal zone B-cell lymphomas (OAMZL) with Chlamydophila psittaci (Cp) infection, suggesting that lymphoma development is dependent upon chronic stimulation by persistent infections. Notwithstanding that, the actual immunopathogenetical mechanisms have not yet been elucidated. As in other B-cell lymphomas, insight into this issue, especially with regard to potential selecting ligands, could be provided by analysis of the immunoglobulin (IG) receptors of the malignant clones. To this end, we studied the molecular features of IGs in 44 patients with OAMZL (40% Cp-positive), identifying features suggestive of a pathogenic mechanism of autoreactivity. Herein, we show that lymphoma cells express a distinctive IG repertoire, with electropositive antigen (Ag)-binding sites, reminiscent of autoantibodies (auto-Abs) recognizing DNA. Additionally, five (11%) cases of OAMZL expressed IGs homologous with autoreactive Abs or IGs of patients with chronic lymphocytic leukemia, a disease known for the expression of autoreactive IGs by neoplastic cells. In contrast, no similarity with known anti-Chlamydophila Abs was found. Taken together, these results strongly indicate that OAMZL may originate from B cells selected for their capability to bind Ags and, in particular, auto-Ags. In OAMZL associated with Cp infection, the pathogen likely acts indirectly on the malignant B cells, promoting the development of an inflammatory milieu, where auto-Ags could be exposed and presented, driving proliferation and expansion of self-reactive B cells.

  16. The role of Variscan to pre-Jurassic active extension in controlling the architecture of the rifted passive margin of Adria: the example of the Canavese Zone (Western Southern Alps, Italy)

    Science.gov (United States)

    Succo, Andrea; De Caroli, Sara; Centelli, Arianna; Barbero, Edoardo; Balestro, Gianni; Festa, Andrea

    2016-04-01

    The Canavese Zone, in the Italian Western Southern Alps, represents the remnant of the Jurassic syn-rift stretching, thinning and dismemberment of the distal passive margin of Adria during the opening of the Penninic Ocean (i.e., Northern Alpine Tethys). Our findings, based on detailed geological mapping, structural analysis and stratigraphic and petrographic observations, document however that the inferred hyper-extensional dismemberment of this distal part of the passive margin of Adria, up to seafloor spreading, was favored by the inherited Variscan geometry and crustal architecture of the rifted margin, and by the subsequent Alpine-related strike-slip deformation. The new field data document, in fact, that the limited vertical displacement of syn-extensional (syn-rift) Jurassic faults was ineffective in producing and justifying the crustal thinning observed in the Canavese Zone. The deformation and thinning of the continental basement of Adria are constrained to the late Variscan time by the unconformable overlying of Late Permian deposits. Late Cretaceous-Early Paleocene and Late Cenozoic strike-slip faulting (i.e., Alpine and Insubric tectonic stages) reactivated previously formed faults, leading to the formation of a complex tectonic jigsaw which only partially coincides with the direct product of the Jurassic syn-rift dismemberment of the distal part of the passive margin of Adria. Our new findings document that this dismemberment of the rifted continental margin of Adria did not simply result from the syn-rift Jurassic extension, but was strongly favored by the inheritance of older (Variscan and post-Variscan) tectonic stages, which controlled earlier lithospheric weakness. The formation of rifted continental margins by extension of continental lithosphere leading to seafloor spreading is a complex and still poorly understood component of the plate tectonic cycle. Geological mapping of rifted continental margins may thus provide significant information to

  17. A splenic marginal zone-like peripheral blood CD27+B220- B cell population is preferentially depleted in HIV type 1-infected individuals.

    Science.gov (United States)

    Morrow, Matthew; Valentin, Antonio; Little, Richard; Yarchoan, Robert; Pavlakis, George N

    2008-04-01

    Peripheral blood CD27(+) B cells are reduced in HIV-1-infected individuals. In healthy individuals, the human peripheral blood CD27(+) B cell pool consists of two subsets defined by the expression, or lack thereof, of the CD45 isoform B220. We investigated the presence of circulating B220(+) and B220(-) memory B cells in HIV(+) individuals and found that the reduction in CD27(+) memory B cells occurs primarily among CD27(+)B220(-) B cells. Studies conducted using healthy controls indicate that CD27(+)B220(-) B cells have a splenic marginal zone like the immunophenotype IgM(hi)IgD(lo)CD21(+)CD23(-), express TLR9, and proliferate and secrete IgG and IgM in response to B cell-specific ODN. CD27(+)B220(+) B cells have the immunophenotype IgM(lo)IgD(hi)CD21(+)CD23(+), express activation-induced cytidine deaminase, and proliferate in response to SAC but do not secrete immunoglobulin. The AICD expression, along with CD86 expression, by CD27(+)B220(+) suggests these cells are of germinal center origin. The preferential depletion of CD27(+)B220(-) B cells mirrors alterations in spleen morphology and resident B cell populations due to HIV infection reported by other investigators and may play an important role in the defective B cell immunity against T-independent pathogens such as pneumococcus observed in HIV-1-infected individuals.

  18. BDNF-modulated spatial organization of Cajal-Retzius and GABAergic neurons in the marginal zone plays a role in the development of cortical organization.

    Science.gov (United States)

    Alcántara, Soledad; Pozas, Esther; Ibañez, Carlos F; Soriano, Eduardo

    2006-04-01

    The present study utilizes nestin-BDNF transgenic mice, which offer a model for early increased brain-derived neurotrophic factor (BDNF) signalling, to examine the role of BDNF in the development of cortical architecture. Our results demonstrate that the premature and homogeneous expression of BDNF, while preserving tangential migration from the ganglionic eminence to the cortex, impairs the final radial migration of GABAergic neurons, as well as their integration in the appropriate cortical layers. Moreover, Cajal-Retzius (CR) cells and GABAergic neurons segregate in the cortical marginal zone (MZ) in response to BDNF signalling, leading to an alternating pattern and a columnar cortical organization, within which the migration of different neuronal populations is specifically affected. These results suggest that both CR and GABAergic neurons play a role in directing the radial migration of late-generated cortical neurons, and that the spatial distribution of these cells in the MZ is critical for the development of correct cortical organization. In addition, reelin secreted by CR cells in the MZ is not sufficient to direct the migration of late-born neurons to the upper cortical layers, which most likely requires the presence of reelin-secreting interneurons in layers V-VI. We propose that in addition to modulating reelin expression, BDNF regulates the patched distribution of CR and GABAergic neurons in the MZ, and that this spatial distribution is involved in the formation of anatomical and/or functional columns and convoluted structures.

  19. Surrogate light chain is required for central and peripheral B-cell tolerance and inhibits anti-DNA antibody production by marginal zone B cells.

    Science.gov (United States)

    Ren, Weicheng; Grimsholm, Ola; Bernardi, Angelina I; Höök, Nina; Stern, Anna; Cavallini, Nicola; Mårtensson, Inga-Lill

    2015-04-01

    Selection of the primary antibody repertoire takes place in pro-/pre-B cells, and subsequently in immature and transitional B cells. At the first checkpoint, μ heavy (μH) chains assemble with surrogate light (SL) chain into a precursor B-cell receptor. In mice lacking SL chain, μH chain selection is impaired, and serum autoantibody levels are elevated. However, whether the development of autoantibody-producing cells is due to an inability of the resultant B-cell receptors to induce central and/or peripheral B-cell tolerance or other factors is unknown. Here, we show that receptor editing is defective, and that a higher proportion of BM immature B cells are prone to undergoing apoptosis. Furthermore, transitional B cells are also more prone to undergoing apoptosis, with a stronger selection pressure to enter the follicular B-cell pool. Those that enter the marginal zone (MZ) B-cell pool escape selection and survive, possibly due to the B-lymphopenia and elevated levels of B-cell activating factor. Moreover, the MZ B cells are responsible for the elevated IgM anti-dsDNA antibody levels detected in these mice. Thus, the SL chain is required for central and peripheral B-cell tolerance and inhibits anti-DNA antibody production by MZ B cells.

  20. Phosphoinositide-3-kinases p110alpha and p110beta mediate S phase entry in astroglial cells in the marginal zone of rat neocortex

    Directory of Open Access Journals (Sweden)

    Rabea eMüller

    2013-03-01

    Full Text Available In cells cultured from neocortex of newborn rats, phosphoinositide-3-kinases of class I regulate the DNA synthesis in a subgroup of astroglial cells. We have studied the location of these cells as well as the kinase isoforms which facilitate the S phase entry. Using dominant negative isoforms as well as selective pharmacological inhibitors we quantified S phase entry by nuclear labeling with bromodeoxyuridine. Only in astroglial cells harvested from the marginal zone of the neocortex inhibition of phosphoinositide-3-kinases reduced the nuclear labeling with bromodeoxyuridine, indicating that neocortical astroglial cells differ in the regulation of proliferation. The two kinase isoforms p110 and p110were essential for S phase entry. p110 diminished the level of the p27Kip1 which inactivates the complex of cyclin E and CDK2 necessary for entry into the S phase. p110phosphorylated and inhibited glycogen synthase kinase-3which can prevent S-phase entry. Taken together, both isoforms mediated S phase in a subgroup of neocortical astroglial cells and acted via distinct pathways.

  1. Gastric lymphoma

    Directory of Open Access Journals (Sweden)

    Sravani Padala

    2016-06-01

    Full Text Available Gastrointestinal lymphomas represent 5-20% of extra nodal lymphomas and mainly occur in the stomach and small intestine. Clinical findings are not specific, thus often determining a delay in the diagnosis. Imaging features at conventional and cross-sectional imaging must be known by the radiologist since he/she plays a pivotal role in the diagnosis and disease assessment, thus assisting in the choice of the optimal treatment to patients. This review focuses on the wide variety of imaging presentation of esophageal, gastric, and small and large bowel lymphoma presenting their main imaging appearances at conventional and cross-sectional imaging, mainly focusing on computed tomography and magnetic resonance, helping in the choice of the best imaging technique for the disease characterization and assessment and the recognition of potential complications. Gastrointestinal tract is the most common extra nodal site involved by lymphoma. Although lymphoma can involve any part of the gastrointestinal tract .The most frequent sites in order of its occurrence are the stomach followed by small intestine and ileocecal region. Gastrointestinal tract lymphoma is usually secondary to the widespread nodal diseases and primary gastrointestinal tract lymphoma is relatively rare. [Int J Res Med Sci 2016; 4(6.000: 2481-2486

  2. Hodgkin lymphoma - children

    Science.gov (United States)

    Lymphoma - Hodgkin - children; Hodgkin disease - children; Cancer - Hodgkin lymphoma - children; Childhood Hodgkin lymphoma ... In children, Hodgkin lymphoma is more likely to occur between ages 15 to 19 years. The cause of this type of ...

  3. Hodgkin Lymphoma (For Kids)

    Science.gov (United States)

    ... Too Tall or Too Short All About Puberty Hodgkin Lymphoma KidsHealth > For Kids > Hodgkin Lymphoma Print A ... of the cool things he's missed. What Is Hodgkin Lymphoma? Lymphoma (say: lim-FOH-mah) is cancer ...

  4. Primary cutaneous B-cell lymphoma: Role of surgery

    Science.gov (United States)

    Parbhakar, Sam; Cin, Arianna Dal

    2011-01-01

    PURPOSE: To evaluate the role of surgery in patients diagnosed with primary cutaneous B-cell lymphoma (PCBCL) – a rare disease entity. The authors offer a rationale for the use of primary surgical excision in the treatment of isolated cutaneous lymphomas. METHODS: A literature review examining the use of primary surgical excision in the treatment of PCBCL was conducted. The lymphoma database at the Juravinski Cancer Centre (Hamilton, Ontario) was searched from January 1995 to July 2008, generating a list of 4924 patients. A simulated computer program was subsequently designed to search for all possible PCBCLs. A retrospective chart review was then conducted on the new list of 1325 patients, identifying 25 patients diagnosed with PCBCL. RESULTS: The mean age of the 25 patients with PCBCL was 59.9 years; nine (36%) were treated with surgery, and sixteen (64%) with radiation. The average follow-up period for patients was 3.6 years. Twenty-four of the 25 patients were completely cured, with only one patient recurring in the radiation subgroup. There were no complications in the surgery subgroup. There were two local complications in the radiation subgroup consisting of chronic ulcerations. CONCLUSIONS: Primary surgical excision is an effective management option in the treatment of PCBCL, particularly the marginal zone and follicle centre subtypes. PMID:22654537

  5. Breast lymphoma

    African Journals Online (AJOL)

    Expression of oestrogen receptor protein as determined by ... lymphomas. While this classification has been fairly widely accepted, a ... minimum a full history and physical examination, chest radiographs ... and hepatic function. A number ...

  6. Hodgkin's Lymphoma

    Science.gov (United States)

    ... for information in your local library and on the Internet. Start your information search with the National Cancer ... www.mayoclinic.org/diseases-conditions/hodgkins-lymphoma/basics/definition/CON-20030667 . Mayo Clinic Footer Legal Conditions and ...

  7. Variations in the Sea Ice Edge and the Marginal Ice Zone on Different Spatial Scales as Observed from Different Satellite Sensor

    Science.gov (United States)

    Markus, Thorsten; Henrichs, John

    2006-01-01

    The Marginal sea Ice Zone (MIZ) and the sea ice edge are the most dynamic areas of the sea ice cover. Knowledge of the sea ice edge location is vital for routing shipping in the polar regions. The ice edge is the location of recurrent plankton blooms, and is the habitat for a number of animals, including several which are under severe ecological threat. Polar lows are known to preferentially form along the sea ice edge because of induced atmospheric baroclinicity, and the ice edge is also the location of both vertical and horizontal ocean currents driven by thermal and salinity gradients. Finally, sea ice is both a driver and indicator of climate change and monitoring the position of the ice edge accurately over long time periods enables assessment of the impact of global and regional warming near the poles. Several sensors are currently in orbit that can monitor the sea ice edge. These sensors, though, have different spatial resolutions, different limitations, and different repeat frequencies. Satellite passive microwave sensors can monitor the ice edge on a daily or even twice-daily basis, albeit with low spatial resolution - 25 km for the Special Sensor Microwave Imager (SSM/I) or 12.5 km for the Advanced Microwave Scanning Radiometer (AMSR-E). Although special methods exist that allow the detection of the sea ice edge at a quarter of that nominal resolution (PSSM). Visible and infrared data from the Advanced Very High Resolution Radiometer (AVHRR) and from the Moderate Resolution Imaging Spectroradiometer (MODIS) provide daily coverage at 1 km and 250 m, respectively, but the surface observations me limited to cloud-free periods. The Landsat 7 Enhanced Thematic Mapper (ETM+) has a resolution of 15 to 30 m but is limited to cloud-free periods as well, and does not provide daily coverage. Imagery from Synthetic Aperture Radar (SAR) instruments has resolutions of tens of meters to 100 m, and can be used to distinguish open water and sea ice on the basis of surface

  8. Primary lymphoma of the brain

    Science.gov (United States)

    Brain lymphoma; Cerebral lymphoma; Primary lymphoma of the central nervous system; Lymphoma - brain ... The cause of primary brain lymphoma is not known. People with a weakened immune system are at high risk for primary lymphoma of the brain. ...

  9. T-Cell Lymphoma

    Science.gov (United States)

    Getting the Facts T-Cell Lymphoma Overview Lymphoma is the most common blood cancer. The two main forms of lymphoma are Hodgkin lymphoma ... develop into lymphomas: B-lymphocytes (B-cells) and T-lymphocytes (T-cells). T-cell lymphomas account for ...

  10. Retinal stem/progenitor cells in the ciliary marginal zone complete retinal regeneration: a study of retinal regeneration in a novel animal model.

    Science.gov (United States)

    Miyake, Ayumi; Araki, Masasuke

    2014-07-01

    Our research group has extensively studied retinal regeneration in adult Xenopus laevis. However, X. laevis does not represent a suitable model for multigenerational genetics and genomic approaches. Instead, Xenopus tropicalis is considered as the ideal model for these studies, although little is known about retinal regeneration in X. tropicalis. In the present study, we showed that a complete retina regenerates at approximately 30 days after whole retinal removal. The regenerating retina was derived from the stem/progenitor cells in the ciliary marginal zone (CMZ), indicating a novel mode of vertebrate retinal regeneration, which has not been previously reported. In a previous study, we showed that in X. laevis, retinal regeneration occurs primarily through the transdifferentiation of retinal pigmented epithelial (RPE) cells. RPE cells migrate to the retinal vascular membrane and reform a new epithelium, which then differentiates into the retina. In X. tropicalis, RPE cells also migrated to the vascular membrane, but transdifferentiation was not evident. Using two tissue culture models of RPE tissues, it was shown that in X. laevis RPE culture neuronal differentiation and reconstruction of the retinal three-dimensional (3-D) structure were clearly observed, while in X. tropicalis RPE culture neither ßIII tubulin-positive cells nor 3-D retinal structure were seen. These results indicate that the two Xenopus species are excellent models to clarify the cellular and molecular mechanisms of retinal regeneration, as these animals have contrasting modes of regeneration; one mode primarily involves RPE cells and the other mode involves stem/progenitor cells in the CMZ.

  11. The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells.

    Science.gov (United States)

    Nagai, Yoshinori; Yanagibashi, Tsutomu; Watanabe, Yasuharu; Ikutani, Masashi; Kariyone, Ai; Ohta, Shoichiro; Hirai, Yoshikatsu; Kimoto, Masao; Miyake, Kensuke; Takatsu, Kiyoshi

    2012-06-01

    Marginal zone (MZ) B cells mount rapid T-cell-independent (T-I) immune responses against microbial components such as LPS. While Toll-like receptor 4 (TLR4) is essential for LPS responses, MZ B cells uniquely express high levels of another LPS sensor Radioprotective 105 (RP105). However, little is known about how RP105 is used by MZ B cells. In this study, we investigated TLR4- or RP105-dependent MZ B cell responses by utilizing agonistic monoclonal antibodies (mAbs) to each receptor. Cross-linking TLR4 and RP105 at the same time with the mAbs induced robust IgM-secreting plasma cell generation as lipid A moiety of LPS. In contrast, stimulation with either mAb alone did not elicit such responses. RP105-deficient MZ B cells failed to produce IgM-secreting plasma cells in response to lipid A. TLR4 or lipid A stimulation of MZ B cells up-regulated their B lymphocyte-induced maturation protein 1 (Blimp-1) and X-box-binding protein 1 (Xbp-1) mRNA expression. RP105 stimulation alone did not give these responses and in fact decreased TLR4-mediated their expression. Compared with wild-type (WT) MZ B cells, RP105-deficient MZ B cells exhibited increased levels of Blimp-1 and Xbp-1 mRNA expression in response to lipid A. Lipid A or TLR4 plus RP105 stimulation induced massive proliferation and expression of Bcl-xL and c-Myc in WT but not RP105-deficient MZ B cells. These responses contributed to TLR4-mediated anti-apoptotic responses in MZ B cells. Thus, RP105 contributes in a unique way to the TLR4-dependent survival, proliferation and plasma cell generation of MZ B cells.

  12. Distribution and ZAP-70 expression of WHO lymphoma categories in Shanxi, China: a review of 447 cases using a tissue microarray technique.

    Science.gov (United States)

    Wang, Jinfen; Young, Lillian; Win, William; Taylor, Clive R

    2005-12-01

    This study aims to assess the distribution of lymphoma subtypes in Shanxi, China, according to the World Health Organization (WHO) classification, and to compare the relative distribution with other areas of the world. H&E-stained tissue sections from the archives of the Shanxi Tumor Hospital, China, were reviewed and 447 cases with sufficient materials were selected for detailed study. A panel of antibodies and probes was assembled, including antibodies to ALK1, bcl-6, CDs 1alpha, 3, 4, 5, 7, 8, 10, 15, 20, 23, 30, 43, 56, 68, 79alpha, and 99, cyclin D1, EMA, kappa, lambda, LMP1, PAX5, TdT, Vs38C and ZAP70, plus EBER RNA probe by in situ hybridization. The 447 lymphoma cases, subtyped according to the WHO classification, were assembled in triplicate into 11 tissue microarrays and examined with the panel of markers described. Among the 447 cases, 385 (82.6%) were confirmed to be non-Hodgkin lymphomas (NHL) and 62 (13.9%) were Hodgkin lymphomas of classic type (CHL). Of the NHL cases, 68.6% were B-cell lymphomas and 30.6% T/NK-cell lymphomas. Histiocytic neoplasms accounted for only three cases (0.8%). Diffuse large B-cell lymphomas (DLBCL) were the most common subtype (35.1%), followed by peripheral T-cell lymphomas unspecified (PTun, 12.0%), extranodal marginal zone B-cell lymphomas (MALT lymphomas, 11.7%), follicular lymphomas (FL, 8.6%), T-lymphoblastic lymphomas (T-LBL, 7.0%), anaplastic large cell lymphomas (ALCL, 4.2%), B small lymphocytic lymphomas (B SLL, 3.6%), and mantle cell lymphomas (MCL, 2.6%). Of 263 B-cell neoplasms, 105 (39.9%) expressed immunoglobulin light chain, including 52 kappa and 53 lambda, detectable in paraffin sections. The incidence of DLBCL was similar to many Western countries and Asia. The frequency of FL was, however, much lower than the usual pattern in Western countries, although NK/T-cell lymphomas were more common (30.6%), similar to other countries in Asia, including Japan and Korea. With regard to markers of EBV infection, 8

  13. Linfomas de la órbita y anexos oculares: Correlación clínico patológica de 25 casos Orbital and ocular adnexal lymphomas: Clinico-pathological correlation in 25 cases

    Directory of Open Access Journals (Sweden)

    Erica A. Rojas Bilbao

    2010-08-01

    Full Text Available Se evaluaron las características clínicas, histológicas y la evolución de una cohorte de pacientes con linfomas de la órbita y anexos oculares. Entre 1995 y 2008 se estudiaron 25 casos de linfomas de la órbita y anexos oculares en un centro oncológico de referencia. En cada caso se analizó el inmunofenotipo usando un panel de anticuerpos monoclonales (CD45, CD20, CD3, CD5, CD23, BCL2, BCL6, BCL10, Ki67, CD30, CD15, BCL1, Kappa, Lambda, CD138. Las lesiones fueron evaluadas utilizando el sistema de clasificación de linfomas (OMS, 2008. Se analizaron 23 linfomas primarios y dos secundarios. Los subtipos histológicos fueron: 16 linfomas B de la zona marginal asociados a las mucosas (MALT, cuatro linfomas difusos de células grandes B, dos linfomas foliculares y un paciente con linfoma Hodgkin. De los 25 casos estudiados, 22 presentaron estadios localizados. El linfoma MALT fue el subtipo más frecuente. En este estudio se observó enfermedad localizada en la mayoría de los casos y con baja progresión a distancia.Clinical, histological features and outcome of a cohort of patients with orbital and adnexal lymphoproliferative tumors were evaluated. Twenty-five cases in an oncologic referral center from 1995 to 2008, were included in the study. Each case had detailed immunophenotypic analysis using a panel of monoclonal antibodies (CD45, CD20, CD3, CD5, CD23, BCL2, BCL6, BCL10, Ki67, CD30, CD15, BCL1, Kappa, Lambda, CD138. Lesions were classified by using WHO (2008 lymphomas classification. Twenty-three patients were found to have primary and two secondary lymphomas. Histological subtypes were: 16 patients with marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma, four diffuse large B cell lymphomas, two mantle cell lymphomas, two follicular lymphomas, and one Hodgkin lymphoma. Among the 25 patients studied, 22 had localized stage. Extranodal marginal zone lymphoma was the most frequent type of primary orbital

  14. Primary Gallbladder Lymphoma in a Male Patient with No Risk Factors Detected Incidentally by CT Colonography

    Science.gov (United States)

    Karia, Monil; Mitsopoulos, Grigorios; Patel, Ketan; Rafique, Akkib; Sheth, Hemant

    2015-01-01

    Primary gallbladder lymphoma, although rare, usually presents in females with symptoms mimicking cholecystitis. We present a rare case of primary gallbladder in an 81-year-old male with no risk factors whose only symptom was weight loss. Routine blood tests including liver function tests were unremarkable. A CT colonography was carried out to exclude colonic malignancy. Unilateral gallbladder wall thickening and lymphadenopathy were incidentally detected and confirmed by ultrasound and a decision for the patient to undergo laparoscopic cholecystectomy and intraoperative cholangiogram was made. Histology confirmed extranodal marginal zone lymphoma with follow-up staging and biopsy of the bone marrow not demonstrating spread. Cholecystectomy was therefore deemed curative and no adjuvant therapy was necessary. Thickening of the gallbladder wall on any imaging with or without symptoms should not be ignored or assumed to be cholecystitis, even in males with no risk factors. In these patients urgent cholecystectomy with intraoperative cholangiogram is indicated with histology and haematology follow-up. PMID:26587306

  15. Antibodies against lytic and latent Kaposi's sarcoma-associated herpes virus antigens and lymphoma in the European EpiLymph case–control study

    Science.gov (United States)

    Benavente, Y; Mbisa, G; Labo, N; Casabonne, D; Becker, N; Maynadie, M; Foretova, L; Cocco, P L; Nieters, A; Staines, A; Bofetta, P; Brennan, P; Whitby, D; de Sanjosé, S

    2011-01-01

    Background: Kaposi's sarcoma-associated herpes virus is associated with primary effusion lymphoma and multicentric Castleman's disease. Methods: Seropositivity to lytic and latent Kaposi's sarcoma herpes virus (KSHV) antigens were examined in 2083 lymphomas and 2013 controls from six European countries. Results: Antibodies against KSHV latent and lytic antigens were detectable in 4.5% and 3.4% of controls, respectively, and 3.6% of cases (P>0.05). The KSHV seropositivity was associated with splenic marginal zone lymphoma (SMZL) (odds ratio (OR)=4.11, 95% confidence interval (CI)=1.57–10.83) and multiple myeloma (OR=0.31, 95% CI=0.11–0.85). Conclusion: The KSHV is unlikely to contribute importantly to lymphomagenesis among immunocompetent subjects. However, the observed association with SMZL may underline a chronic antigen mechanism in its aetiology. PMID:21952625

  16. Influence of timing of sea ice retreat on phytoplankton size during marginal ice zone bloom period on the Chukchi and Bering shelves

    Science.gov (United States)

    Fujiwara, A.; Hirawake, T.; Suzuki, K.; Eisner, L.; Imai, I.; Nishino, S.; Kikuchi, T.; Saitoh, S.-I.

    2016-01-01

    The size structure and biomass of a phytoplankton community during the spring bloom period can affect the energy use of higher-trophic-level organisms through the predator-prey body size relationships. The timing of the sea ice retreat (TSR) also plays a crucial role in the seasonally ice-covered marine ecosystem, because it is tightly coupled with the timing of the spring bloom. Thus, it is important to monitor the temporal and spatial distributions of a phytoplankton community size structure. Prior to this study, an ocean colour algorithm was developed to derive phytoplankton size index FL, which is defined as the ratio of chlorophyll a (chl a) derived from cells larger than 5 µm to the total chl a, using satellite remote sensing for the Chukchi and Bering shelves. Using this method, we analysed the pixel-by-pixel relationships between FL during the marginal ice zone (MIZ) bloom period and TSR over the period of 1998-2013. The influences of the TSR on the sea surface temperature (SST) and changes in ocean heat content (ΔOHC) during the MIZ bloom period were also investigated. A significant negative relationship between FL and the TSR was widely found in the shelf region during the MIZ bloom season. However, we found a significant positive (negative) relationship between the SST (ΔOHC) and TSR. Specifically, an earlier sea ice retreat was associated with the dominance of larger phytoplankton during a colder and weakly stratified MIZ bloom season, suggesting that the duration of the nitrate supply, which is important for the growth of large-sized phytoplankton in this region (i.e. diatoms), can change according to the TSR. In addition, under-ice phytoplankton blooms are likely to occur in years with late ice retreat, because sufficient light for phytoplankton growth can pass through the ice and penetrate into the water columns as a result of an increase in solar radiation toward the summer solstice. Moreover, we found that both the length of the ice-free season

  17. Revisiting the B-cell compartment in mouse and humans: more than one B-cell subset exists in the marginal zone and beyond

    Directory of Open Access Journals (Sweden)

    Garraud Olivier

    2012-11-01

    -cells. This review thus aims to describe novel findings regarding the B-cell compartments found in the mouse as a model organism, and in human physiology and pathology. It must be emphasised that some differences are noticeable between the mouse and human systems, thus increasing the complexity of B-cell compartmentalisation. Special attention will be given to the (lymph node and spleen marginal zones, which represent major crossroads for B-cell types and functions and a challenge for understanding better the role of B-cell specificities in innate and adaptive immunology.

  18. Ocean Bottom Gamma-Ray Anomaly Around Methane Seeps Related to Gas Hydrate- Bearing Zone in The Eastern Margin of Japan Sea and Off Southwest Taiwan

    Science.gov (United States)

    Machiyama, H.; Kinoshita, M.; Lin, S.; Matsumoto, R.; Soh, W.

    2008-12-01

    JAMSTEC has conducted the ocean bottom gamma-ray measurement using ROVs and Submersibles since 1997. Gamma-ray spectrometer utilizes 3-inch spherical NaI(Tl) scintillator and the signal processor including DA converter in a pressure case. After processing data, we get total count rate (intensity value: count per second (cps)) of gamma ray and contents of K, U-, and Th-series radionuclides. The sensor was equipped to the side of the sample basket or foot of ROVs and submersibles, and always touches the seafloor when ROVs completely landed. Their results are posted on JAMSTEC website as a database. On the basis of past achievements, we present the results of the ocean bottom gamma-ray measurement at the methane seep sites related to gas hydrate off Joetsu in the eastern margin of Japan Sea and off southwest Taiwan. Off Joetsu: A number of mounds, large pockmarks (20 - 50 m deep and 200 - 500 m across), gas plumes, and gas hydrate are found at water depth of 900 - 1000 m in the Umitaka Spur and the Joetsu Knoll. Gamma-ray intensity values are 50 - 70 cps in normal muddy seafloor. On the other hand, the intensity values are 100 - 200 cps around methane venting sites, bacteria mats, and 'collapsed hydrate zone' which has an undulating, rugged seafloor with carbonate nodules and gravels. Contents of each radionuclide are also high. Low U/Th ratio suggests that there is less contribution of Rn accompanied with a recent fault activity. Off southwest Taiwan: Large, dense chemosynthetic communities, associated with carbonate pavements, were discovered at water depth of about 1100 - 1200 m on the top of the Formosa Ridge. Gamma-ray intensity values in normal muddy seafloor (120 - 150 cps) are higher than those around Japan. Since Th-series radionuclide easily absorbs other particles, it is commonly included in surface sediments. This may cause higher content of Th-series radionuclide in normal muddy seafloor. On the other hand, anomaly of gamma-ray intensity (200 - 300 cps

  19. Influence of timing of sea ice retreat on phytoplankton size during marginal ice zone bloom period in the Chukchi and Bering shelves

    Directory of Open Access Journals (Sweden)

    A. Fujiwara

    2015-08-01

    Full Text Available Timing of sea ice retreat (TSR as well as cell size of primary producers (i.e., phytoplankton plays crucial roles in seasonally ice-covered marine ecosystem. Thus, it is important to monitor the temporal and spatial distribution of phytoplankton community size structure. Prior to this study, an ocean color algorithm has been developed to derive phytoplankton size index FL, which is defined as the ratio of chlorophyll a derived from the cells larger than 5 μm to the total chl a using satellite remote sensing for the Chukchi and Bering shelves. Using this method, we analyzed pixel-by-pixel relationships between FL during marginal ice zone (MIZ bloom period and TSR over a period of 1998–2013. The influence of TSR on sea surface temperature (SST and changes in ocean heat content (ΔOHC during the MIZ bloom period were also investigated. A significant negative relationship between FL and TSR was widely found in the shelf region during MIZ bloom season. On the other hand, we found a significant positive (negative relationship between SST (ΔOHC and TSR. That is, earlier sea-ice retreat was associated with a dominance of larger phytoplankton during a colder and weakly stratified MIZ bloom season, suggesting that duration of nitrate supply, which is important for large-sized phytoplankton growth in this region (i.e., diatoms, can change according to TSR. In addition, under-ice phytoplankton blooms are likely to occur in years with late ice retreat, because sufficient light for phytoplankton growth can pass through the ice and penetrate into the water columns due to an increase in solar radiation toward the summer solstice. Moreover, we found not only the length of ice-free season but also annual median of FL positively correlated with annual net primary production (APP. Thus, both phytoplankton community composition and growing season are important for APP in the study area. Our findings showed quantitative relationship between the inter

  20. Mapping and assessing variability in the Antarctic marginal ice zone, pack ice and coastal polynyas in two sea ice algorithms with implications on breeding success of snow petrels

    Science.gov (United States)

    Stroeve, Julienne C.; Jenouvrier, Stephanie; Campbell, G. Garrett; Barbraud, Christophe; Delord, Karine

    2016-08-01

    Sea ice variability within the marginal ice zone (MIZ) and polynyas plays an important role for phytoplankton productivity and krill abundance. Therefore, mapping their spatial extent as well as seasonal and interannual variability is essential for understanding how current and future changes in these biologically active regions may impact the Antarctic marine ecosystem. Knowledge of the distribution of MIZ, consolidated pack ice and coastal polynyas in the total Antarctic sea ice cover may also help to shed light on the factors contributing towards recent expansion of the Antarctic ice cover in some regions and contraction in others. The long-term passive microwave satellite data record provides the longest and most consistent record for assessing the proportion of the sea ice cover that is covered by each of these ice categories. However, estimates of the amount of MIZ, consolidated pack ice and polynyas depend strongly on which sea ice algorithm is used. This study uses two popular passive microwave sea ice algorithms, the NASA Team and Bootstrap, and applies the same thresholds to the sea ice concentrations to evaluate the distribution and variability in the MIZ, the consolidated pack ice and coastal polynyas. Results reveal that the seasonal cycle in the MIZ and pack ice is generally similar between both algorithms, yet the NASA Team algorithm has on average twice the MIZ and half the consolidated pack ice area as the Bootstrap algorithm. Trends also differ, with the Bootstrap algorithm suggesting statistically significant trends towards increased pack ice area and no statistically significant trends in the MIZ. The NASA Team algorithm on the other hand indicates statistically significant positive trends in the MIZ during spring. Potential coastal polynya area and amount of broken ice within the consolidated ice pack are also larger in the NASA Team algorithm. The timing of maximum polynya area may differ by as much as 5 months between algorithms. These

  1. Clinical analysis of 670 cases in two trials of the European Organization for the Research and Treatment of Cancer Lymphoma Cooperative Group subtyped according to the Revised European-American Classification of Lymphoid Neoplasms: a comparison with the Working Formulation.

    Science.gov (United States)

    Pittaluga, S; Bijnens, L; Teodorovic, I; Hagenbeek, A; Meerwaldt, J H; Somers, R; Thomas, J; Noordijk, E M; De Wolf-Peeters, C

    1996-05-15

    In the Working Formulation (WF), non-Hodgkin's lymphomas (NHL) are grouped according to their clinical behavior. These disorders are listed as entities defined by morphology, phenotype, and cytogenetics in the proposed Revised European-American Classification of Lymphoid Neoplasms (REAL), the clinical relevance of which is still debated. We analyzed 670 NHL cases included in two randomized clinical trials (EORTC 20855 WF-intermediate/high-grade and 20856 WF-low-grade malignancy) with histologic material available for review. Based on hematoxylin-eosin-stained sections, 77% of cases could be subtyped. Immunophenotyping was considered to be mandatory only in diagnosing T-cell lymphoma and anaplastic large-cell lymphoma. Of 522 cases subtyped, 11% were mantle cell lymphoma (MCL), 5% were marginal zone B-cell lymphoma (MZBCL), 46% were follicle center lymphoma, and 32% were diffuse large B-cell lymphoma. Statistical analysis and comparisons between classifications were made only within each trial and treatment group. MCL and MZBCL were characterized by a shorter median survival (3.4 and 4.1 years, respectively) in comparison with low- and intermediate-grade WF groups (> 9.3 and 5.8 years, respectively). In terms of progression-free survival, MCL showed a behavior similar to the low-grade group, with frequent relapses. Follicle center cell lymphomas behaved as low-grade lymphomas as defined by the WF and diffuse large B-cell lymphomas as the WF-intermediate grade group. Because several NHL entities have a clinical behavior of their own, their recognition by the REAL classification offers clinicians additional information that is not obtained when the WF is used.

  2. Lymphoma cytogenetics.

    Science.gov (United States)

    Dave, Bhavana J; Nelson, Marilu; Sanger, Warren G

    2011-12-01

    Lymphomas are a heterogeneous group of neoplasms with distinct morphologic, immunologic, and cytogenetic characteristics. Overlapping morphologic and immunophenotypic features often makes accurate diagnosis difficult. Cytogenetics helps simplify the diagnostic complexities presented in transforming and progressive lymphoid malignancies. Genetic studies using technical advances such as fluorescence in situ hybridization and the newer approaches of array comparative genomic hybridization and gene expression profiling play a critical and often defining role in the diagnosis, progression, prognosis, and therapeutic stratification. This article reviews characteristic cytogenetic abnormalities in specific subtypes of lymphomas at diagnosis, disease progression, and prognosis.

  3. Primary gastrointestinal non-Hodgkin lymphoma in adults: clinicopathologic and survival characteristics.

    Science.gov (United States)

    Radić-Kristo, Delfa; Planinc-Peraica, Ana; Ostojić, Slobodanka; Vrhovac, Radovan; Kardum-Skelin, Ika; Jaksić, Branimir

    2010-06-01

    Primary non-Hodgkin lymphomas of gastrointestinal tract (PGI-NHL) are the most common extranodal lymphomas with an increasing incidence. The incidence, clinicopathologic characteristics, treatment and survival were assessed in 39 successive, newly diagnosed PGI-NHL patients (23 male and 16 female) treated at "Merkur" University Hospital. The aim of the study was to precisely evaluate their characteristics and compare them with the results reported from other similar studies. The most common site of PGI-NHL was stomach (n = 29, 74%), followed by small intestine (n = 5, 13%), and colon and rectosigmoid (n = 5, 13%). According to the Ann Arbor classification, 34 (87%) patients had stage IE and IIE, and five patients (12%) stage IIIE and IVE. According to World Health Organization (WHO) classification, 29 (87%) patients had diffuse large B-cell lymphoma (DLCBL), two had mantle cell lymphoma, and seven (18%) had marginal zone B-cell lymphoma-mucosa associated tissue (MALT). Twenty-six (66%) patients underwent surgical resection followed by chemotherapy, ten (26%) were treated with chemotherapy alone, and three (8%) were treated surgically. Complete remission was achieved in 28 (72%) and partial remission in seven (18%) patients. Four (10%) patients had progressive disease. In our patients, the major prognostic factor for outcome was the stage of disease. Patients with localized lymphoma (stage IE and IIE) had a significantly longer overall survival: 85% at five years and 65% at ten years. Patients with extended disease (stage IIIE and IVE) had overall survival less than 33%. The prognostic power of erythrocyte sedimentation rate (ESR), total protein, serum albumin, LDH concentration and activity was analyzed. Of these parameters, only LDH had a statistically significant effect on overall survival. In conclusion, our patient group was comparable to other literature reports on PGI-NHL patients according to clinicopathologic characteristics. Disease stage and LDH were the

  4. Mucosa-Associated Lymphoid-Tissue Lymphoma of the Cecum and Rectum: A Case Report

    Science.gov (United States)

    Nam, Myung Jin; Park, Sung Chan; Hong, Chang Won; Han, Kyung Su; Sohn, Dae Kyung; Park, Weon Seo; Chang, Hee Jin; Oh, Jae Hwan

    2017-01-01

    A colonic mucosa-associated lymphoid-tissue (MALT) lymphoma is relatively rare compared to lymphomas of the stomach or small intestine. We present a case of a MALT lymphoma in the cecum and rectum found during screening colonoscopy. A 54-year-old female, who had undergone right-breast-conserving surgery with axillary dissection due to an invasive ductal carcinoma and a left-breast excisional biopsy due to microcalcification following adjuvant chemoradiation therapy 3 years earlier, was found to have 3-mm-sized smooth elevated lesions in both the cecum and rectum. No pathologic lesion or lymphadenopathy was found at any other site, but chronic gastritis negative for Helicobacter pylori infection was found. The polyps were removed by using an endoscopic biopsy and revealed an extra nodal marginal zone B-cell MALT lymphoma, showing positive for CD3 and CD20 by immunohistochemical staining. The patient underwent close observation without any additional treatment and has shown no evidence of recurrence as of her last visit. PMID:28289662

  5. Fluorescence in situ hybridization (FISH analysis of primary ocular adnexal MALT lymphoma

    Directory of Open Access Journals (Sweden)

    Harada Mine

    2006-10-01

    Full Text Available Abstract Background It remains unknown whether primary ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma is a homogeneous entity, as there are few reports of the results of cytogenetic or molecular analyses of these tumors. Methods We performed interphase fluorescence in situ hybridization (FISH analysis to detect translocations and aneuploidy in 34 cases of primary ocular adnexal MALT lymphoma, and reviewed the histopathological findings. Correlations between the results of FISH analysis, the histopathological features and the clinical data were also analyzed. Results Among the 34 cases, FISH analysis revealed t(14;18(q32;q21 in one case, trisomy 3 in 21 cases (62%, and trisomy 18 in 16 cases (47%. The cases with trisomy 18 had significantly more prominent lymphoepithelial lesions (LELs and less nodularity in the tumors. In regard to the clinical correlations, tumors with trisomy 18 were observed predominantly in females and younger patients; also, in the majority of the cases, the tumor was of conjunctival origin. All the cases with recurrence showed trisomy 18 in the tumor. Conclusion Primary ocular adnexal MALT lymphoma is a significantly heterogeneous entity. Cases with trisomy 18 may have unique clinicopathological features.

  6. Cytokine polymorphisms in Th1/Th2 pathway genes, body mass index, and risk of non-Hodgkin lymphoma.

    Science.gov (United States)

    Chen, Yingtai; Zheng, Tongzhang; Lan, Qing; Foss, Francine; Kim, Christopher; Chen, Xuezhong; Dai, Min; Li, Yumin; Holford, Theodore; Leaderer, Brian; Boyle, Peter; Chanock, Stephen J; Rothman, Nathaniel; Zhang, Yawei

    2011-01-13

    We conducted a population-based, case-control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared with those with BMI less than 25 kg/m(2), women with BMI more than or equal to 25 kg/m(2) had 50% to 90% increased risk of NHL among women who carried IFNGR2 (rs9808753) AA, IL5 (rs2069812) CT/TT, IL7R (rs1494555) AA, and TNF (rs1799724) CC genotypes, but no increased risk among women with IFNGR2 AG/GG, IL5 CC, IL7R AG/GG, and TNF CT/TT genotypes. A significant interaction with BMI was only observed for IFNGR2 (rs9808753 P(forinteraction) = .034) and IL7R (rs1494555 P(forinteraction) = .016) for NHL overall; IL7R (rs1494555 P(forinteraction) = .016) and TNF (1799724 P(forinteraction) = .031) for B-cell lymphoma; and IL5 (rs2069812 P(forinteraction) = .034) for T-cell lymphoma. After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma. The results suggest that common genetic variation in Th1/Th2 pathway genes may modify the association between BMI and NHL risk.

  7. A Phase II Study of Doxycycline in Relapsed NHL

    Science.gov (United States)

    2016-10-27

    Adult Diffuse Large B-Cell Lymphoma; Mantle Cell Lymphoma Recurrent; Lymphoma, Follicular; Marginal Zone B-Cell Lymphoma; Malignant Lymphoma - Lymphoplasmacytic; Waldenstrom Macroglobulinemia; Small Lymphocytic Lymphoma; Chronic Lymphocytic Leukemia (CLL); T-Cell Lymphoma

  8. A comparison between protein profiles of B cell subpopulations and mantle cell lymphoma cells

    Directory of Open Access Journals (Sweden)

    Lehtiö Janne

    2009-11-01

    Full Text Available Abstract Background B-cell lymphomas are thought to reflect different stages of B-cell maturation. Based on cytogenetics and molecular markers, mantle cell lymphoma (MCL is presumed to derive predominantly from naïve, pre-germinal centre (pre-GC B lymphocytes. The aim of this study was to develop a method to investigate the similarity between MCL cells and different B-cell compartments on a protein expression level. Methods Subpopulations of B cells representing the germinal centre (GC, the pre-GC mantle zone and the post-GC marginal zone were isolated from tonsils using automated magnetic cell sorting (AutoMACS of cells based on their expression of CD27 and IgD. Protein profiling of the B cell subsets, of cell lines representing different lymphomas and of primary MCL samples was performed using top-down proteomics profiling by surface-enhanced laser detection/ionization time-of-flight mass spectrometry (SELDI-TOF-MS. Results Quantitative MS data of significant protein peaks (p-value Conclusion AutoMACS sorting generates sufficient purity to enable a comparison between protein profiles of B cell subpopulations and malignant B lymphocytes applying SELDI-TOF-MS. Further validation with an increased number of patient samples and identification of differentially expressed proteins would enable a search for possible treatment targets that are expressed during the early development of MCL.

  9. Model estimating the effect of marginal ice zone processes on the phytoplankton primary production and air-sea flux of CO2 in the Barents Sea

    Science.gov (United States)

    Dvornikov, Anton; Sein, Dmitry; Ryabchenko, Vladimir; Gorchakov, Victor; Martjyanov, Stanislav

    2016-04-01

    This study is aimed to assess the impact of sea ice on the primary production of phytoplankton (PPP) and air-sea CO2 flux in the Barents Sea. To get the estimations, we apply a three-dimensional eco-hydrodynamic model based on the Princeton Ocean Model which includes: 1) a module of sea ice with 7 categories, and 2) the 11-component module of marine pelagic ecosystem developed in the St. Petersburg Branch, Institute of Oceanology. The model is driven by atmospheric forcing, prescribed from the reanalysis NCEP / NCAR, and conditions on the open sea boundary, prescribed from the regional model of the atmosphere-ocean-sea ice-ocean biogeochemistry, developed at Max Planck Institute for Meteorology, Hamburg. Comparison of the model results for the period 1998-2007 with satellite data showed that the model reproduces the main features of the evolution of the sea surface temperature, seasonal changes in the ice extent, surface chlorophyll "a" concentration and PPP in the Barents Sea. Model estimates of the annual PPP for whole sea, APPmod, appeared in 1.5-2.3 times more than similar estimates, APPdata, from satellite data. The main reasons for this discrepancy are: 1) APPdata refers to the open water, while APPmod, to the whole sea area (under the pack ice and marginal ice zone (MIZ) was produced 16 - 38% of PPP); and 2) values of APPdata are underestimated because of the subsurface chlorophyll maximum. During the period 1998-2007, the modelled maximal (in the seasonal cycle) sea ice area has decreased by 15%. This reduction was accompanied by an increase in annual PPP of the sea at 54 and 63%, based, respectively, on satellite data and the model for the open water. According to model calculations for the whole sea area, the increase is only 19%. Using a simple 7-component model of oceanic carbon cycle incorporated into the above hydrodynamic model, the CO2 exchange between the atmosphere and sea has been estimated in different conditions. In the absence of biological

  10. [Plasmablastic lymphoma].

    Science.gov (United States)

    Fernández-Álvarez, Rubén; Sancho, Juan-Manuel; Ribera, Josep-María

    2016-11-04

    Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of non-Hodgkin lymphoma that commonly occurs in human immunodeficiency virus (HIV)-positive individuals, and affects oral sites. Occasionally, it has been described in HIV-negative patients and involving non-oral sites. Pathologically, PBL is a high-grade B-cell lymphoma that displays the immunophenotype of a terminally differentiated B-lymphocyte with loss of B-cell markers (CD20) and expression of plasma-cell antigens. Epstein-Barr virus infection and MYC rearrangements are frequently observed. Treatment of PBL is challenging because of the lack of established treatment and poor outcomes, with median survival times shorter than one year. In this review, we discuss the clinical and epidemiologic spectrum of PBL as well as its distinct pathological features. Finally, we summarize the currently available approaches for the treatment of patients with PBL. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  11. Magmatic evolution in the N-Gondwana margin related to the opening of the Rheic Ocean—evidence from the Upper Parautochthon of the Galicia-Trás-os-Montes Zone and from the Central Iberian Zone (NW Iberian Massif)

    Science.gov (United States)

    Dias da Silva, Ícaro; Díez Fernández, Rubén; Díez-Montes, Alejandro; González Clavijo, Emilio; Foster, David A.

    2016-06-01

    LA-MC-ICP-MS U-Pb zircon ages and whole-rock geochemical data obtained from volcanic rocks erupted in the northern margin of Gondwana provide new insights on the polyphase magmatic evolution of the NW Iberian domain during the establishment of passive margin conditions in Lower Paleozoic times. The U-Pb data show crystallization ages of ca. 455 Ma for two calc-alkaline rhyolites sampled in the Upper Parautochthon of the eastern Galicia—Trás-os-Montes Zone (GTMZ) and for an intraplate basalt intruded into Middle Ordovician slates of the autochthonous series of the Central Iberian Zone (CIZ). Together with previous data, the ages obtained reveal a periodic magmatic activity across the northern Gondwana margin during the Lower Paleozoic, which is comparable to that observed in NE Iberia and in other massifs of the Mediterranean realm. Both geochronological and geochemical data reinforce paleontological and stratigraphic evidences for paleogeographic proximity between these domains and contribute to the recognition of extensional-related magmatism along the northern margin of Central Gondwana associated with the opening of the Rheic Ocean.

  12. Primary thymic mucosa-associated lymphoid tissue lymphoma with multiple thin walled lung cysts: case report and literature review

    Institute of Scientific and Technical Information of China (English)

    Lung-Yun Kang; Szu-Pei Ho; Yi-Pin Chou

    2013-01-01

    Mucosa-associated lymphoid tissue (MALT) lymphoma of the thymus is rare.We reported a case of a 37-year-old Chinese female with Sj(o)gren's syndrome and hyperglobulinemia.She suffered from chronic cough for 3 weeks.Chest computed tomography (CT) demonstrated a multiloculated cystic mass in mediastinum prevascular space and multiple lung cysts.Laboratory exam of autoimmune markers showed positive of antinuclear antibody (ANA),Sj(o)gren's syndrome A (SSA),Sj(o)gren's syndrome B (SSB),and rheumatoid factors (RF).Thymectomy with lymph node dissection was performed.The pathology report revealed thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue.Under immunohistochemical stains,CD20 and Bcl-2 were positive.No evidence of recurrence of disease was found.

  13. Testicular lymphoma

    DEFF Research Database (Denmark)

    Møller, Michael Boe; d'Amore, F; Christensen, Bjarne Egelund

    1994-01-01

    In a Danish population-based non-Hodgkin's lymphoma registry, 2687 newly diagnosed patients were registered from 1983 to 1992. 39 had testicular involvement (TL) (incidence 0.26/10(5)/year). Median age was 71 years. 24 cases had localised and 15 had disseminated disease. Histologically, all cases...... were diffuse (65% diffuse centroblastic type). Of the 27 tested, 11% were of T- and 89% of B-immunophenotype. In localised cases, where surgery was supplemented by combination chemotherapy (CCT), the relapse rate was 15.4%. The relapse rate for cases with localised disease treated with other regimens...

  14. Similar prognosis of transformed and de novo diffuse large B-cell lymphomas in patients treated with immunochemotherapy.

    Science.gov (United States)

    Sorigue, Marc; Garcia, Olga; Baptista, Maria Joao; Sancho, Juan-Manuel; Tapia, Gustavo; Mate, José Luis; Feliu, Evarist; Navarro, José-Tomás; Ribera, Josep-Maria

    2017-03-22

    The prognosis of diffuse large B-cell lymphomas (DLBCL) transformed from indolent lymphoma (TL) has been considered poorer than that of de novo DLBCL. However, it seems to have improved since the introduction of rituximab. We compared the characteristics (including the cell-of-origin), and the prognosis of 29 patients with TL and 101 with de novo DLBCL treated with immunochemotherapy. Patients with TL and de novo DLBCL had similar characteristics. All TL cases evolving from follicular lymphoma were germinal-center B-cell-like, while those TL from marginal zone lymphoma or chronic lymphocytic leukemia were non-germinal-center B-cell-like. The complete response rate was similar in TL and de novo DLBCL (62 vs. 66%, P=.825). The 5-year overall and progression-free survival probabilities (95% CI) were 59% (40-78) and 41% (22-60) for TL and 63% (53-73) and 60% (50-70) for de novo DLBCL, respectively (P=.732 for overall survival and P=.169 for progression-free survival). In this study, the prognosis of TL and de novo DLBCL treated with immunochemotherapy was similar. The role of intensification with stem cell transplantation in the management of TL may be questionable in the rituximab era. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  15. Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma

    Directory of Open Access Journals (Sweden)

    Gascoyne Randy D

    2009-11-01

    Full Text Available Abstract Background Translocations are hallmarks of non-Hodgkin lymphoma (NHL genomes. Because lymphoid cell development processes require the creation and repair of double stranded breaks, it is not surprising that disruption of this type of DNA repair can cause cancer. The members of the MRE11-RAD50-NBS1 (MRN complex and BLM have central roles in maintenance of DNA integrity. Severe mutations in any of these genes cause genetic disorders, some of which are characterized by increased risk of lymphoma. Methods We surveyed the genetic variation in these genes in constitutional DNA of NHL patients by means of gene re-sequencing, then conducted genetic association tests for susceptibility to NHL in a population-based collection of 797 NHL cases and 793 controls. Results 114 SNPs were discovered in our sequenced samples, 61% of which were novel and not previously reported in dbSNP. Although four variants, two in RAD50 and two in NBS1, showed association results suggestive of an effect on NHL, they were not significant after correction for multiple tests. Conclusion These results suggest an influence of RAD50 and NBS1 on susceptibility to diffuse large B-cell lymphoma and marginal zone lymphoma. Larger association and functional studies could confirm such a role.

  16. Color Doppler sonography and angioscintigraphy in hepatic Hodgkin's lymphoma

    Institute of Scientific and Technical Information of China (English)

    Mirjana V Stojkovi(c); Vera M Artiko; Irena B Radoman; Slavko J Kne(z)evi(c); Snezana M Luki(c); Mirko D Kerkez; Nebojsa S Leki(c); Andrija A Anti(c); Marinko M (Z)vela; Vitomir I Rankovi(c); Milorad N Petrovi(c); Dragana P (S)obi(c); Vladimir B Obradovi(c)

    2009-01-01

    AIM: To estimate the characteristics of Color Doppler findings and the results of hepatic radionuclide angiography (HRA) in secondary Hodgkin's hepatic lymphoma.METHODS: The research included patients with a diagnosis of Hodgkin's lymphoma with metastatic focal lesions in the liver and controls. Morphologic characteristics of focal liver lesions and hemodynamic parameters were examined by pulsed and Color Doppler in the portal, hepatic and splenic veins were examined. Hepatic perfusion index (HPI) estimated by HRA was calculated.RESULTS: In the majority of patients, hepatomegaly was observed. Lesions were mostly hypoechoic and mixed, solitary or multiple. Some of the patients presented with dilated splenic veins and hepatofugal blood flow. A pulse wave was registered in the centre and at the margins of lymphoma. The average velocity of the pulse wave was higher at the margins ( P >0.05). A continuous venous wave was found only at the margins of lymphoma. There was no linear correlation between lymphoma size and velocity of pulse and continuous wave ( r = 390, P < 0.01). HPI was significantly lower in patients with lymphomas than in controls ( P < 0.05), pointing out increased arterial perfusion in comparison to portal perfusion.CONCLUSION: Color Doppler ultrasonography is a sensitive method for the detection of neovascularization in Hodgkin's hepatic lymphoma and estimation of its intensity. Hepatic radionuclide angiography can additionally help in the assesment of vascularisation of liver lesions.

  17. Stages of Adult Hodgkin Lymphoma

    Science.gov (United States)

    ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ...

  18. Stages of Childhood Hodgkin Lymphoma

    Science.gov (United States)

    ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ...

  19. Antiviral therapy of hepatitis C as curative treatment of indolent B-cell lymphoma

    Science.gov (United States)

    Merli, Michele; Carli, Giuseppe; Arcaini, Luca; Visco, Carlo

    2016-01-01

    The association of hepatitis C virus (HCV) and B-cell non-Hodgkin lymphomas (NHL) has been highlighted by several epidemiological and biological insights; however the most convincing evidence is represented by interventional studies demonstrating the capability of antiviral treatment (AT) with interferon (IFN) with or without ribavirin to induce the regression of indolent lymphomas, especially of marginal-zone origin. In the largest published retrospective study (100 patients) the overall response rate (ORR) after first-line IFN-based AT was 77% (44% complete responses) and responses were sustainable (median duration of response 33 mo). These results were confirmed by a recent meta-analysis on 254 patients, demonstrating an ORR of 73%. Moreover this analysis confirmed the highly significant correlation between the achievement of viral eradication sustained virological response (SVR) and hematological responses. Two large prospective studies demonstrated that AT is associated with improved survival and argue in favor of current guidelines’ recommendation of AT as preferential first-line option in asymptomatic patients with HCV-associated indolent NHL. The recently approved direct-acting antiviral agents (DAAs) revolutionized the treatment of HCV infection, leading to SVR approaching 100% in all genotypes. Very preliminary data of IFN-free DAAs therapy in indolent HCV-positive NHL seem to confirm their activity in inducing lymphoma regression.

  20. Treatment Options for Non-Hodgkin Lymphoma

    Science.gov (United States)

    ... Lymphoma Treatment AIDS-Related Lymphoma Treatment Chronic Lymphocytic Leukemia Treatment (small lymphocytic lymphoma) Mycosis Fungoides (Including Sézary Syndrome) Treatment (cutaneous T-cell lymphoma) Primary CNS Lymphoma Treatment Non-Hodgkin lymphoma ...

  1. Stages of Adult Non-Hodgkin Lymphoma

    Science.gov (United States)

    ... Lymphoma Treatment AIDS-Related Lymphoma Treatment Chronic Lymphocytic Leukemia Treatment (small lymphocytic lymphoma) Mycosis Fungoides (Including Sézary Syndrome) Treatment (cutaneous T-cell lymphoma) Primary CNS Lymphoma Treatment Non-Hodgkin lymphoma ...

  2. Peripheral T-Cell Lymphoma

    Science.gov (United States)

    Getting the Facts Peripheral T-Cell Lymphoma Overview Lymphoma is the most common blood cancer. The two main forms of lymphoma are Hodgkin lymphoma and ... develop into lymphomas: B-lymphocytes (B-cells) and T-lymphocytes (T-cells). Peripheral T-cell lymphoma (PTCL) ...

  3. Early Cambrian granitoids of North Gondwana margin in the transition from a convergent setting to intra-continental rifting (Ossa-Morena Zone, SW Iberia)

    Science.gov (United States)

    Sánchez-García, T.; Pereira, M. F.; Bellido, F.; Chichorro, M.; Silva, J. B.; Valverde-Vaquero, P.; Pin, Ch.; Solá, A. R.

    2014-07-01

    Two distinct Cambrian magmatic pulses are recognized in the Ossa-Morena Zone (SW Iberia): an early rift-(ER) and a main rift-related event. This Cambrian magmatism is related to intra-continental rifting of North Gondwana that is thought to have culminated in the opening of the Rheic Ocean in Lower Ordovician times. New data of whole-rock geochemistry (19 samples), Sm-Nd-Sr isotopes (4 samples) and ID-TIMS U-Pb zircon geochronology (1 sample) of the Early Cambrian ER plutonic rocks of the Ossa-Morena Zone are presented in this contribution. The ER granitoids (Barreiros, Barquete, Calera, Salvatierra de los Barros and Tablada granitoid Massifs) are mostly peraluminous granites. The Sm-Nd isotopic data show moderate negative ɛNdt values ranging from -3.5 to +0.1 and TDM ages greatly in excess of emplacement ages. Most ER granitoids are crustal melts. However, a subset of samples shows a transitional anorogenic alkaline tendency, together with more primitive isotopic signatures, documenting the participation of lower crust or mantle-derived sources and suggesting a local transient advanced stage of rifting. The Barreiros granitoid is intrusive into the Ediacaran basement of the Ossa-Morena Zone (Série Negra succession) and has yielded a crystallization age of 524.7 ± 0.8 Ma consistent with other ages of ER magmatic pulse. This age: (1) constrains the age of the metamorphism developed in the Ediacaran back-arc basins before the intrusion of granites and (2) defines the time of the transition from the Ediacaran convergent setting to the Lower Cambrian intra-continental rifting in North Gondwana.

  4. A Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Josephine Taverna

    2014-01-01

    Full Text Available A 65-year-old gentleman presented with left groin swelling over the course of two months. Physical exam revealed nontender left inguinal adenopathy, and computed tomography scans detected multiple lymph nodes in the mesenteric, aortocaval, and right common iliac regions. An excisional lymph node biopsy was performed. Pathologic evaluation demonstrated follicular center site which stained positive for PAX5, CD20, CD10, Bcl-2, Bcl-6, and mantle zone cells. These findings demonstrated CCND1 and CD5 positivity, suggesting composite lymphoma comprising follicular lymphoma (FL with in situ mantle cell lymphoma (MCLIS. FL is known as indolent non-Hodgkin lymphoma; however, the clinical significance of a coexisting MCLIS continues to be elusive, and optimal management of these patients remains largely unknown. This case illustrates the diagnostic and therapeutic challenges of composite lymphomas. This paper also discusses advances in molecular pathogenesis and lymphoma genomics which offer novel insights into these rare diseases.

  5. Rift brittle deformation of SE-Brazilian continental margin: Kinematic analysis of onshore structures relative to the transfer and accommodation zones of southern Campos Basin

    Science.gov (United States)

    Savastano, Vítor Lamy Mesiano; Schmitt, Renata da Silva; Araújo, Mário Neto Cavalcanti de; Inocêncio, Leonardo Campos

    2017-01-01

    High-resolution drone-supported mapping and traditional field work were used to refine the hierarchy and kinematics of rift-related faults in the basement rocks and Early Cretaceous mafic dikes onshore of the Campos Basin, SE-Brazil. Two sets of structures were identified. The most significant fault set is NE-SW oriented with predominantly normal displacement. At mesoscale, this fault set is arranged in a rhombic pattern, interpreted here as a breached relay ramp system. The rhombic pattern is a penetrative fabric from the thin-section to regional scale. The second-order set of structures is an E-W/ESE-WNW system of normal faults with sinistral component. These E-W structures are oriented parallel with regional intrabasinal transfer zones associated with the earliest stages of Campos Basin's rift system. The crosscutting relationship between the two fault sets and tholeiitic dikes implies that the NE-SW fault set is the older feature, but remained active until the final stages of rifting in this region as the second-order fault set is older than the tholeiitic dikes. Paleostresses estimated from fault slip inversion method indicated that extension was originally NW-SE, with formation of the E-W transfer, followed by ESE-WNW oblique opening associated with a relay ramp system and related accommodation zones.

  6. [Effect of soil texture in unsaturated zone on soil nitrate accumulation and groundwater nitrate contamination in a marginal oasis in the middle of Heihe River basin].

    Science.gov (United States)

    Su, Yong-Zhong; Yang, Xiao; Yang, Rong

    2014-10-01

    In irrigated agricultural ecosystems, the accumulation, distribution and transfer of nitrate nitrogen (NO(3-)-N) in soil profile and groundwater nitrate pollution were influenced by irrigation and fertilization, and were closely related to soil textural characteristics. In this study, a monitoring section with 10 groundwater observation wells along Heihe River flood land-old oasis croplands-newly cultivated sandy croplands-fixed sandy land outside oasis was established in Pingchuan desert-oasis in Linze county in the middle of Heihe river basin, and groundwater NO(3-)-N concentration was continuously monitored. Soil texture and NO(3-)-N concentration in the unsaturated zone at different landscape locations were determined. The NO(3-)-N transfer change in soil profile, nitrate leaching of soils with different texture and fertility levels in the 0-100 cm layer were analyzed. The results indicated that the vertical distribution of soil texture was sandy loam in the 0-130 cm depth, loam in the 130-190 cm and clay loam in the 190-300 cm for the old oasis croplands. For newly cultivated sandy croplands, sand content was more than 80% in each soil layer of the 0-300 cm profile, although a thin clay layer occurred in the 140-160 cm depth. The clay layer occurred 160 cm below the sand-fixing zone outside oasis. There were significant correlations between soil NO(3-)-N concentration and silt + clay content, and the order of significant degree was the natural soils of sandy lands > the newly cultivated sandy croplands > the old oasis croplands. The loss of N leaching was closely correlated to the silt + caly content in the 0-100 cm soil depth. The groundwater NO(3-)-N concentration varied from 1.01 to 5.17 mg · L(-1), with a mean value of 2.65 mg · L(-1) and from 6.6 to 29.5 mg · L(-1), with an average of 20.8 mg · L(-1) in the area of old oasis croplands and the newly cultivated croplands, respectively. The averaged groundwater NO(3-)-N concentration in the area of newly

  7. Hydrogeochemical comparison and effects of overlapping redox zones on groundwater arsenic near the Western (Bhagirathi sub-basin, India) and Eastern (Meghna sub-basin, Bangladesh) margins of the Bengal Basin

    Science.gov (United States)

    Mukherjee, Abhijit; von Brömssen, Mattias; Scanlon, Bridget R.; Bhattacharya, Prosun; Fryar, Alan E.; Hasan, Md. Aziz; Ahmed, Kazi Matin; Chatterjee, Debashis; Jacks, Gunnar; Sracek, Ondra

    2008-07-01

    Although arsenic (As) contamination of groundwater in the Bengal Basin has received wide attention over the past decade, comparative studies of hydrogeochemistry in geologically different sub-basins within the basin have been lacking. Groundwater samples were collected from sub-basins in the western margin (River Bhagirathi sub-basin, Nadia, India; 90 samples) and eastern margin (River Meghna sub-basin; Brahmanbaria, Bangladesh; 35 samples) of the Bengal Basin. Groundwater in the western site (Nadia) has mostly Ca-HCO3 water while that in the eastern site (Brahmanbaria) is much more variable consisting of at least six different facies. The two sites show differences in major and minor solute trends indicating varying pathways of hydrogeochemical evolution However, both sites have similar reducing, postoxic environments (pe: + 5 to - 2) with high concentrations of dissolved organic carbon, indicating dominantly metal-reducing processes and similarity in As mobilization mechanism. The trends of various redox-sensitive solutes (e.g. As, CH4, Fe, Mn, NO3-, NH4+, SO42-) indicate overlapping redox zones, leading to partial redox equilibrium conditions where As, once liberated from source minerals, would tend to remain in solution because of the complex interplay among the electron acceptors.

  8. Fault locking and slip rate deficit of the Haiyuan-Liupanshan fault zone in the northeastern margin of the Tibetan Plateau

    Science.gov (United States)

    Li, Yanchuan; Shan, Xinjian; Qu, Chunyan; Wang, Zhenjie

    2016-12-01

    GPS-derived horizontal velocities, geologic fault slip rates and earthquake-derived fault slip vector azimuths are inverted simultaneously for fault coupling and slip rate deficit on the Haiyuan-Liupanshan fault in the northeastern margin of the Tibetan Plateau. Along the Haiyuan fault, the results show 3.2-6.2 mm/yr of left-lateral strike-slip, and the strike-slip transformed into thrusting deformation (2.8-3.5 mm/yr) along the Liupanshan fault. The results suggest full coupling down to ∼10 km along the Haiyuan fault. Significant portions from the Jinqianghe fault to the Maomaoshan fault, however, are locked to ∼23 km depth. The abrupt change in fault coupling coincides with the Tianzhu seismic gap. High slip rate deficit (3.0-4.5 mm/yr) and seismic moment accumulation rate are also interpreted along the seismic gap. The Liupanshan fault is locked to 15-20 km depth. A high seismic moment accumulation rate, low slip rate deficit (2.0-3.2 mm/yr) and scarcity of large seismic event over the last 1400 years may imply high strain accumulation on the fault. The results demonstrate that crustal deformation in the northeastern Tibetan Plateau is dominated by elastic block rotation. We also conclude that deformation due to fault coupling is limited along the near-field (less than 50 km with velocities less than 2 mm/yr) of the Haiyuan-Liupanshan fault.

  9. Effects of Human Alterations on Global River Basins and their Associated Coastal Zones: focus on River-dominated Ocean Margins (RiOMars)

    Science.gov (United States)

    Dürr, H. H.; Van Cappellen, P.; Meybeck, M.; Laruelle, G. G.; Mayorga, E.; Hartmann, J.; Maavara, T.; Bouwman, L.; Seitzinger, S.

    2013-12-01

    Coastal systems connected to large rivers, mostly major delta systems or river-dominated ocean margins (RiOMars), make up channels, creating a braided network of streams and many islands (Dürr et al. 2011). Here, we discuss controls on the different nutrient forms delivered to different coastal environments, and how they are assessed (Global-NEWS and other approaches), with a special focus on large deltas and RiOMars. Drivers and impacts of global change will be explored through the Millenium Assessment Scenarios and how the fluxes to these different coastal systems might change. An increasing role is also played by aquaculture in different coastal types as a non-insignificant source of nutrients. World-wide distribution of coastal types and their related river basins (Dürr et al. 2011). Characteristics of types of near-shore coastal areas and their associated river basins Greenland and Antarctica excepted. Data from Dürr et al. (2011) and the Global-NEWS program (Seitzinger et al. 2005 and Mayorga et al. 2010).

  10. International Lymphoma Epidemiology Consortium

    Science.gov (United States)

    The InterLymph Consortium, or formally the International Consortium of Investigators Working on Non-Hodgkin's Lymphoma Epidemiologic Studies, is an open scientific forum for epidemiologic research in non-Hodgkin's lymphoma.

  11. Non-Hodgkin's Lymphoma

    Science.gov (United States)

    ... These include the lymphatic vessels, tonsils, adenoids, spleen, thymus and bone marrow. Occasionally, non-Hodgkin's lymphoma involves ... understand the possible link between pesticides and the development of non-Hodgkin's lymphoma. Older age. Non-Hodgkin's ...

  12. Ocular Adnexal Follicular Lymphoma

    DEFF Research Database (Denmark)

    Rasmussen, Peter K; Coupland, Sarah E; Finger, Paul T

    2014-01-01

    , and 31 (45%) had stage IIE lymphoma. Patients with disseminated lymphoma had stage IIIE (9 of 19 [47%]) and stage IV (10 of 19 [53%]) disease, whereas patients with a relapse of systemic lymphoma presented with stage IE (8 of 10 [80%]), stage IIE (1 of 10 [10%]), and stage IIIE (1 of 10 [10%]) disease...

  13. Clinicopathologic features of lymphoma: analyses of 664 cases%664例淋巴瘤临床病理分析

    Institute of Scientific and Technical Information of China (English)

    宋琳; 邢晓明; 冉雯雯; 李宏; 邵玉铭; 李玉军

    2013-01-01

    目的 根据WHO(2008版)造血和淋巴肿瘤分类标准,探讨青岛地区淋巴瘤的病理类型及分布特点.方法 收集2008年8月~2011年8月青岛大学医学院附属医院诊治664例淋巴瘤,复习其临床资料、HE及免疫组化切片.按WHO(2008版)分类新标准进行病理诊断及分类.结果 664例淋巴瘤中,非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL)621例(93.52%),霍奇金淋巴瘤(Hodgkin's lymphoma,HL)43例(6.48%).NHL中B细胞淋巴瘤485例(78.10%),T和NK细胞淋巴瘤136例(21.90%).NHL中,发病构成比居前5位分别为弥漫性大B细胞淋巴瘤-非特殊类型(diffuse large B-cell lymphoma-unspecified,DLBCL-NOS)277例(44.61%)、黏膜相关淋巴组织结外边缘区淋巴瘤(extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type,MALT)48例(7.73%)、结外NK/T细胞淋巴瘤45例(7.25%)、外周T细胞淋巴瘤-非特殊类型(peripheral T-cell lymphoma-unspecified,PTCL-NOS)33例(5.31%)、慢性淋巴细胞性白血病/小淋巴细胞淋巴瘤(chronic lymphocytic leukemia/small lymphocytic lymphoma,CLL/SLL)32例(5.15%).HL中以结节硬化型经典型霍奇金淋巴瘤(nodular sclerosis classical Hodgkin's lymphoma,NSCHL)为多(18例,41.86%).NHL和HL患者中,男女比例为1.52:1,平均年龄53岁(2~95岁).NHL(115例,18.52%)和HL(26例,60.47%)起病部位均以颈部淋巴结为多.结论 664例淋巴瘤中,NHL发病远多于HL,NHL中以DLBCL-NOS多见,HL中以NSCHL多见.大部分淋巴瘤类型以男性发病为多,起病部位以颈部淋巴结为多.%Purpose To study the pathologic types and characteristics of lymphoma based on the Word Health Organization classification of tumors of hematopoietic and lymphoid tissues ( 2008 ) in Qingdao area.Methods Clinical data of lymphoma from August 2008 to August 2011 in the affiliated hospital of Qingdao University Medical College were collected and reviewed, including morphological, immunological and clinical characteristics.According to

  14. Plasmablastic lymphoma

    Science.gov (United States)

    Han, Xiao; Duan, Minghui; Hu, Lixing; Zhou, Daobin; Zhang, Wei

    2017-01-01

    Abstract Background: Plasmablastic lymphoma (PBL) is a B-cell malignancy associated with human immunodeficiency virus (HIV). PBL could also influence the HIV-negative patients. The study aimed to identify prognostic factors for survival among Chinese PBL patients. Materials and methods: Eligible patients from literature and Peking Union Medical College Hospital (PUMCH) were included in this study. Clinical characteristics and immunophenotypic data were extracted. Kaplan–Meier curve was used to describe the survival status. Cox regression was used for multivariate analysis. Results: A total of 60 Chinese PBL patients were included, including 54 patients from 36 published articles and 6 new patients that have not been reported. The median overall survival was 7 months (95% confidence interval 3.853–10.147 months). An overwhelming majority (79.31%) of the included cases were Ann Arbor stage IV patients. All the Chinese PBL patients were HIV-negative; 46.81% were Epstein-Barr virus-positive. CD38, CD138, or MUM1 was positively expressed in more than 80% of patients; CD20 expression was also found in 22.03% of cases. Kaplan–Meier curve revealed obvious differences in patient survival between patients in primary stages and advanced stages, as well as between patients with kidney involvement and those without kidney involvement. Cox regression analysis indicated that stage and age were 2 prognostic factors for patient survival. Conclusions: Advanced stage might be associated with poor prognosis among PBL HIV-negative patients in Chinese. PMID:28248855

  15. Effects of bottom water dissolved oxygen variability on copper and lead fractionation in the sediments across the oxygen minimum zone, western continental margin of India.

    Science.gov (United States)

    Chakraborty, Parthasarathi; Chakraborty, Sucharita; Jayachandran, Saranya; Madan, Ritu; Sarkar, Arindam; Linsy, P; Nath, B Nagender

    2016-10-01

    This study describes the effect of varying bottom-water oxygen concentration on geochemical fractionation (operational speciation) of Cu and Pb in the underneath sediments across the oxygen minimum zone (Arabian Sea) in the west coast of India. Both, Cu and Pb were redistributed among the different binding phases of the sediments with changing dissolved oxygen level (from oxic to hypoxic and close to suboxic) in the bottom water. The average lability of Cu-sediment complexes gradually decreased (i.e., stability increased) with the decreasing dissolved oxygen concentrations of the bottom water. Decreasing bottom-water oxygen concentration increased Cu association with sedimentary organic matter. However, Pb association with Fe/Mn-oxyhydroxide phases in the sediments gradually decreased with the decreasing dissolved oxygen concentration of the overlying bottom water (due to dissolution of Fe/Mn oxyhydroxide phase). The lability of Pb-sediment complexes increased with the decreasing bottom-water oxygen concentration. This study suggests that bottom-water oxygen concentration is one of the key factors governing stability and lability of Cu and Pb complexes in the underneath sediment. Sedimentary organic matter and Fe/Mn oxyhydroxide binding phases were the major hosting phases for Cu and Pb respectively in the study area. Increasing lability of Pb-complexes in bottom sediments may lead to positive benthic fluxes of Pb at low oxygen environment. Copyright © 2016 Elsevier B.V. All rights reserved.

  16. Influence of marginal effect on settling of the foundation of a steel cylindrical reservoir in the zone of the adjoining assembly

    Energy Technology Data Exchange (ETDEWEB)

    Snitko, N.K.; Mangushev, R.A.

    1980-01-01

    During operation of steel vertical cylindrical reservoirs with diameter over 20 m with height of the wall 12 m which are erected on weak ground, the greatest danger comes from vertical deformations in the foundation in the region of the adjoining assembly of the wall and the bottom. Consequently, correct evaluation of engineering geological conditions of the construction platforms, as well as the technique for calculating stresses and deformations in the foundation of oil field reservoirs are urgent tasks. A method is suggested of calculation analysis which uses the method of movements, on the condition of equilibrium of the foundation assembly, whose rotation clockwise is assumed to be positive. Analysis shows that the calculation made with regard for shifting of the foundation guarantees a decrease in the stress in the wall and the bottom of the reservoir, and the rotation of the foundation ring has a special effect on reduction in stress. In the zone of the adjoining assembly of the wall and the bottom, local vertical deformations of the foundation develop whose magnitude depends on the size of the foundation ring and the engineering-geological characteristics of the foundation.

  17. Recognition of hyper-extended rifted margin remnants in the internal zone of the Alpine belt: A tribute to Marco Beltrando

    Science.gov (United States)

    Mohn, Geoffroy; Manatschal, Gianreto

    2016-04-01

    Marco Beltrando was part of the young generation of Alpine geologists who challenged the interpretation of the Western Alps by combining a classical field approach and modern techniques (e.g. 40Ar/39Ar and (U-Th)/He thermochronology). His work provides the foundation to re-interpret some of the classical sections through the Alpine belt and may impact the way of thinking about the nature and structure of internal parts of collisional orogens. This contribution will present the main outcomes of the work of Marco Beltrando and their implications for the understanding of Alpine type orogens. Since his PhD, Marco Beltrando focused most of his work on the study of the internal parts of the Western Alps. He investigated in great details the complex, multiphase structural and metamorphic evolution of the Penninic units in the Western Alps. He concluded that these units went through several cycles of shortening and extension during the Alpine orogeny, with major implications for the Alps but also other orogenic belts. After his PhD, he focused his research on the pre-orogenic evolution of the Alpine belt. He first worked on the Petit St. Bernard area, where he identified relics of the former hyper-extended Tethyan rifted margin. Thanks to his work and his amazing knowledge of the Western Alps, he understood the potential importance of rift-inheritance in controlling the architecture and evolution of the Alpine belt. In parallel to the study of the orogenic evolution, he developed a new methodology to recognize rift-related lithostratigraphic units in highly deformed and metamorphosed parts of the Alps. His innovative work allowed a re-assessment of several areas in the Western Alps and demonstrates the importance of rift inheritance. Recently, he started a new research project on the evolution of the Southern Alps highlighting the importance of heating and cooling cycles resulting from complex successions of rifting events. In spite of his young age, Marco Beltrando was at

  18. A high resolution paleo-record of export production using deep-sea coral stable isotope values from a unique HNLC zone on the California Margin

    Science.gov (United States)

    Wright, Z.

    2015-12-01

    The Sur Ridge, located ~30 km off the Big Sur coast of central California, represents a unique system within the highly productive California Current ecosystem. Its unique high nutrient, but low chlorophyll characteristics are not fully understood. Time series of bulk stable carbon (δ13C) and stable nitrogen (δ15N) isotopes can help us better understand past changes in nutrient dynamics and phytoplankton community baselines for this region in order to better predict future changes. Deep-sea proteinaceous corals are particularly powerful paleoarchives of past ocean conditions. These organisms serve as "living sediment traps," incorporating the stable isotope values of exported particulate organic material (POM) from the surface into their growth layers. The longevity of bamboo corals (Isidella, up to 400 years) makes them excellent resources for creating high resolution, centennial time series of δ13C and δ15N dynamics. Bamboo corals used in this study were harvested during summer of 2014 from 1220 to 1300 m depths. Two corals were milled in sub-millimeter intervals to generate a 200 year time series at approximately three year temporal resolution. Over the past 200 years, deep-sea coral δ13C values ranged from -15.7 to -19.0‰ and δ15N values ranged from 14.4 to 15.9‰, consistent with earlier data from the CA margin. The δ13C records were characterized by long periods of remarkable stability, contrasted with several large shifts (~1900 and ~1960) in δ13C of approximately 1‰. We hypothesize that these shifts likely reflect changes in plankton composition or production associated with regional climate shifts. The δ15N data were more dynamic, including several large shifts (1940 - 1960), as well as periods of apparent decadal scale oscillation (1825 - 1925 and 1965 - present). These shifts may reflect changes in the source or utilization of nitrogen at the base of the food web. Together, these data give us a first look at baseline stability of

  19. Genetic variation in cell death genes and risk of non-Hodgkin lymphoma.

    Directory of Open Access Journals (Sweden)

    Johanna M Schuetz

    Full Text Available BACKGROUND: Non-Hodgkin lymphomas are a heterogeneous group of solid tumours that constitute the 5(th highest cause of cancer mortality in the United States and Canada. Poor control of cell death in lymphocytes can lead to autoimmune disease or cancer, making genes involved in programmed cell death of lymphocytes logical candidate genes for lymphoma susceptibility. MATERIALS AND METHODS: We tested for genetic association with NHL and NHL subtypes, of SNPs in lymphocyte cell death genes using an established population-based study. 17 candidate genes were chosen based on biological function, with 123 SNPs tested. These included tagSNPs from HapMap and novel SNPs discovered by re-sequencing 47 cases in genes for which SNP representation was judged to be low. The main analysis, which estimated odds ratios by fitting data to an additive logistic regression model, used European ancestry samples that passed quality control measures (569 cases and 547 controls. A two-tiered approach for multiple testing correction was used: correction for number of tests within each gene by permutation-based methodology, followed by correction for the number of genes tested using the false discovery rate. RESULTS: Variant rs928883, near miR-155, showed an association (OR per A-allele: 2.80 [95% CI: 1.63-4.82]; p(F = 0.027 with marginal zone lymphoma that is significant after correction for multiple testing. CONCLUSIONS: This is the first reported association between a germline polymorphism at a miRNA locus and lymphoma.

  20. Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes.

    Science.gov (United States)

    Machiela, Mitchell J; Lan, Qing; Slager, Susan L; Vermeulen, Roel C H; Teras, Lauren R; Camp, Nicola J; Cerhan, James R; Spinelli, John J; Wang, Sophia S; Nieters, Alexandra; Vijai, Joseph; Yeager, Meredith; Wang, Zhaoming; Ghesquières, Hervé; McKay, James; Conde, Lucia; de Bakker, Paul I W; Cox, David G; Burdett, Laurie; Monnereau, Alain; Flowers, Christopher R; De Roos, Anneclaire J; Brooks-Wilson, Angela R; Giles, Graham G; Melbye, Mads; Gu, Jian; Jackson, Rebecca D; Kane, Eleanor; Purdue, Mark P; Vajdic, Claire M; Albanes, Demetrius; Kelly, Rachel S; Zucca, Mariagrazia; Bertrand, Kimberly A; Zeleniuch-Jacquotte, Anne; Lawrence, Charles; Hutchinson, Amy; Zhi, Degui; Habermann, Thomas M; Link, Brian K; Novak, Anne J; Dogan, Ahmet; Asmann, Yan W; Liebow, Mark; Thompson, Carrie A; Ansell, Stephen M; Witzig, Thomas E; Tilly, Hervé; Haioun, Corinne; Molina, Thierry J; Hjalgrim, Henrik; Glimelius, Bengt; Adami, Hans-Olov; Roos, Göran; Bracci, Paige M; Riby, Jacques; Smith, Martyn T; Holly, Elizabeth A; Cozen, Wendy; Hartge, Patricia; Morton, Lindsay M; Severson, Richard K; Tinker, Lesley F; North, Kari E; Becker, Nikolaus; Benavente, Yolanda; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; Staines, Anthony; Lightfoot, Tracy; Crouch, Simon; Smith, Alex; Roman, Eve; Diver, W Ryan; Offit, Kenneth; Zelenetz, Andrew; Klein, Robert J; Villano, Danylo J; Zheng, Tongzhang; Zhang, Yawei; Holford, Theodore R; Turner, Jenny; Southey, Melissa C; Clavel, Jacqueline; Virtamo, Jarmo; Weinstein, Stephanie; Riboli, Elio; Vineis, Paolo; Kaaks, Rudolph; Boeing, Heiner; Tjønneland, Anne; Angelucci, Emanuele; Di Lollo, Simonetta; Rais, Marco; De Vivo, Immaculata; Giovannucci, Edward; Kraft, Peter; Huang, Jinyan; Ma, Baoshan; Ye, Yuanqing; Chiu, Brian C H; Liang, Liming; Park, Ju-Hyun; Chung, Charles C; Weisenburger, Dennis D; Fraumeni, Joseph F; Salles, Gilles; Glenn, Martha; Cannon-Albright, Lisa; Curtin, Karen; Wu, Xifeng; Smedby, Karin E; de Sanjose, Silvia; Skibola, Christine F; Berndt, Sonja I; Birmann, Brenda M; Chanock, Stephen J; Rothman, Nathaniel

    2016-04-15

    Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82,P-value = 8.5 × 10(-5)]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51,P-value = 4.0 × 10(-10)). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere length may increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk.

  1. Detection of MYD88 L265P mutations in formalin-fixed and decalcified BM biopsies from patients with lymphoplasmacytic lymphoma.

    Science.gov (United States)

    Capaldi, Ianina Belén; May, Annette M; Schmitt-Graeff, Annette; Follo, Marie; Aumann, Konrad; Kayser, Gian; Perazzo, Juan Carlos; Werner, Martin; Fisch, Paul

    2014-08-01

    The diagnosis of bone marrow (BM) infiltration by Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) poses a diagnostic challenge in hematopathology. No definitive morphology or immunophenotype is able to distinguish between infiltration of paraffin-embedded BM sections by WM/LPL and other indolent lymphomas, in particular those of the splenic marginal zone (SMZL) which may also show plasmacytic maturation. An oncogenic gain-of-function mutation (L265P) in the human MYD88 gene has been found to be present in most cases of WM/LPL, yet is absent in most other cases of B-cell chronic lymphoproliferative disorders (LPD), including SMZL. Here, we compare two newly developed diagnostic protocols for detection of this mutation in paraffin-embedded archival tissues which are particularly applicable to decalcified BM biopsies. Sanger sequencing can easily detect levels of BM infiltration above 15% by WM lymphoplasmacytic cells, while the allele-specific PCR can detect the L265P mutation in BM infiltrations below 1% of lymphoma cells. We show that these methods are easily applicable to archival BM specimens and markedly improve diagnostic accuracy of BM infiltrations by indolent B-cell lymphomas.

  2. Distribution and Composition of Thiotrophic Mats in the Hypoxic Zone of the Black Sea (150–170 m Water Depth, Crimea Margin)

    Science.gov (United States)

    Jessen, Gerdhard L.; Lichtschlag, Anna; Struck, Ulrich; Boetius, Antje

    2016-01-01

    At the Black Sea chemocline, oxygen- and sulfide-rich waters meet and form a niche for thiotrophic pelagic bacteria. Here we investigated an area of the Northwestern Black Sea off Crimea close to the shelf break, where the chemocline reaches the seafloor at around 150–170 m water depth, to assess whether thiotrophic bacteria are favored in this zone. Seafloor video transects were carried out with the submersible JAGO covering 20 km2 on the region between 110 and 200 m depth. Around the chemocline we observed irregular seafloor depressions, covered with whitish mats of large filamentous bacteria. These comprised 25–55% of the seafloor, forming a belt of 3 km width around the chemocline. Cores from the mats obtained with JAGO showed higher accumulations of organic matter under the mats compared to mat-free sediments. The mat-forming bacteria were related to Beggiatoa-like large filamentous sulfur bacteria based on 16S rRNA sequences from the mat, and visual characteristics. The microbial community under the mats was significantly different from the surrounding sediments and enriched with taxa affiliated with polymer degrading, fermenting and sulfate reducing microorganisms. Under the mats, higher organic matter accumulation, as well as higher remineralization and radiotracer-based sulfate reduction rates were measured compared to outside the mat. Mat-covered and mat-free sediments showed similar degradability of the bulk organic matter pool, suggesting that the higher sulfide fluxes and subsequent development of the thiotrophic mats in the patches are consequences of the accumulation of organic matter rather than its qualitative composition. Our observations suggest that the key factors for the distribution of thiotrophic mat-forming communities near to the Crimean shelf break are hypoxic conditions that (i) repress grazers, (ii) enhance the accumulation and degradation of labile organic matter by sulfate-reducers, and (iii) favor thiotrophic filamentous bacteria

  3. Distribution and Composition of Thiotrophic Mats in the Hypoxic Zone of the Black Sea (150-170 m Water Depth, Crimea Margin).

    Science.gov (United States)

    Jessen, Gerdhard L; Lichtschlag, Anna; Struck, Ulrich; Boetius, Antje

    2016-01-01

    At the Black Sea chemocline, oxygen- and sulfide-rich waters meet and form a niche for thiotrophic pelagic bacteria. Here we investigated an area of the Northwestern Black Sea off Crimea close to the shelf break, where the chemocline reaches the seafloor at around 150-170 m water depth, to assess whether thiotrophic bacteria are favored in this zone. Seafloor video transects were carried out with the submersible JAGO covering 20 km(2) on the region between 110 and 200 m depth. Around the chemocline we observed irregular seafloor depressions, covered with whitish mats of large filamentous bacteria. These comprised 25-55% of the seafloor, forming a belt of 3 km width around the chemocline. Cores from the mats obtained with JAGO showed higher accumulations of organic matter under the mats compared to mat-free sediments. The mat-forming bacteria were related to Beggiatoa-like large filamentous sulfur bacteria based on 16S rRNA sequences from the mat, and visual characteristics. The microbial community under the mats was significantly different from the surrounding sediments and enriched with taxa affiliated with polymer degrading, fermenting and sulfate reducing microorganisms. Under the mats, higher organic matter accumulation, as well as higher remineralization and radiotracer-based sulfate reduction rates were measured compared to outside the mat. Mat-covered and mat-free sediments showed similar degradability of the bulk organic matter pool, suggesting that the higher sulfide fluxes and subsequent development of the thiotrophic mats in the patches are consequences of the accumulation of organic matter rather than its qualitative composition. Our observations suggest that the key factors for the distribution of thiotrophic mat-forming communities near to the Crimean shelf break are hypoxic conditions that (i) repress grazers, (ii) enhance the accumulation and degradation of labile organic matter by sulfate-reducers, and (iii) favor thiotrophic filamentous bacteria

  4. Grey zone lymphoma with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma:clinicopathologic characterization of 16 cases showing different patterns%具有弥漫性大B细胞淋巴瘤和经典型霍奇金淋巴瘤中间特点的灰区淋巴瘤临床病理特征

    Institute of Scientific and Technical Information of China (English)

    王磊; 王维格; 李小秋; 郭晔; 朱雄增

    2014-01-01

    目的:探讨具有弥漫性大B细胞淋巴瘤(DLBCL)和经典型霍奇金淋巴瘤(CHL)中间特点的灰区淋巴瘤的临床和病理特征,旨在深化对该类交界性B细胞肿瘤的认识。方法回顾性分析16例典型病例的临床资料、组织学形态和免疫组织化学表型。结果16例患者男女比为1.7∶1.0,平均年龄40.2岁。8例表现为外周淋巴结病灶,5例表现为纵隔受累。根据组织学形态和免疫表型特点将该组病变分为三种模式。模式1:4例,形态学上类似于CHL,但肿瘤细胞CD20弥漫强阳性;模式2:8例,形态学上类似于DLBCL,但肿瘤细胞异质性表达CD20、PAX5,同时表达CD30和/或CD15;模式3:4例,形态特点介于CHL和DLBCL之间,肿瘤细胞不同程度地表达CD20、CD30和CD15。11例受检病例中,6例肿瘤细胞表达EB病毒潜伏膜蛋白1。临床上,绝大多数患者对联合利妥昔单抗和CHOP( R-CHOP)方案的免疫化疗不敏感。结论通过描述三种常见的组织学模式,提出了具有DLBCL和CHL中间特点的灰区淋巴瘤的诊断标准。这类肿瘤外周型病变和纵隔病变的病理特点似有不同。目前对这组交界性肿瘤尚无有效治疗方法,患者预后较差。%Objective To profile the clinicopathologic features of a series of grey zone lymphoma (GZL) cases with hybrid features of diffuse large B-cell lymphoma ( DLBCL) and classical Hodgkin lymphoma (CHL), with a purpose to gain an in-depth understanding of the borderline B-cell neoplasm. Methods The clinical, morphologic and immunophenotyical characteristics of 16 cases were retrospectively analyzed.Results The patients were mostly male adults , with a male to female ratio of 1.7∶1.0 and a mean age of 40.2 years.Eight patients presented with peripheral nodal lesions and five cases with mediastinal involvement .Histologically and immunophenotypically , the 16 cases were classified into three sub-categories.In 4

  5. Improvement of early response criteria of the PET with F.D.G. in the aggressive lymphoma: importance of the reference area; Amelioration des criteres de reponse precoce de la TEP au FDG dans le lymphome agressif: importance de la zone de reference

    Energy Technology Data Exchange (ETDEWEB)

    Yeddes, I.; Hamza, F.; El Bez, I.; Lin, C.; Evangelista, E.; Meignan, M.; Itti, E. [CHU Henri-Mondor, Service de medecine nucleaire, 94 - Creteil (France); Dupuis, J.; Haioun, C. [CHU Henri-Mondor, Service d' hematologie, 94 - Creteil (France)

    2010-07-01

    Purpose: PET with F.D.G. allows to identify early the patients that respond or not to the first line chemotherapy, from the second therapy. However, the interpretation criteria currently used (Juweid, international harmonization project. JCO 2007) are adapted to evaluation of end of treatment and non to early evaluation, for which the reference zone allowing to judge the positivity of a residual tumor must be evaluated. Conclusions: To interpret the early response to therapy in aggressive lymphoma, it seems justified to refer to a higher reference level ( liver) than this one advocated in international current criteria (mediastinum). (N.C.)

  6. 40Ar/39Ar Thermochronometry of the Sisters Shear Zone, Stewart Island, New Zealand; Implications for Driving Mechanisms and Multi-Stage Breakup of the Pacific Margin of Gondwana

    Science.gov (United States)

    Kula, J. L.; Tulloch, A. J.; Spell, T. L.; Wells, M. L.

    2006-12-01

    New mapping, structural analysis, and thermochronometry of the Sisters Shear Zone (SSZ) indicate this detachment system played a role in continental extension leading to separation of New Zealand from West Antarctica. The SSZ extends 40 km along the southeast coast of Stewart Island, southernmost New Zealand with a footwall consisting of variably deformed 300-105 Ma granites and a hanging wall of coarse non-marine conglomerate and undeformed granite. The trace of the SSZ is subparallel to seafloor isochrons adjacent to the Campbell Plateau and stretching lineations throughout the shear zone are oriented 155/335° ± 10°; consistent with the spreading direction along the Pacific-Antarctic Ridge. Mica and K-feldspar 40Ar/39Ar thermochronometry of SSZ footwall rocks indicate moderately rapid cooling (20-30°C/Ma) over the interval ~89-82 Ma followed by slow cooling. Interpretation of the moderately rapid cooling as due to tectonic denudation makes the SSZ the youngest structure yet identified in New Zealand related to Gondwana breakup. The decrease in cooling rate at 82 Ma coincides with the age of oldest seafloor adjacent to the Campbell Plateau (chron 33r), possibly reflecting the mechanical transition from continental extension to lithospheric rupture and Pacific-Antarctic ridge initiation. The orientation of the SSZ has implications for driving mechanisms of extension. Major arc/forearc terrains through South Island and Stewart Island trend northwest-southeast, and include paired plutonic belts of thick inboard arc terrain adjacent to a thin older, outboard arc belt. Crustal collapse due to the across-arc gradient in gravitational potential energy would have resulted in extension directed normal to the arc trend. The SSZ cuts the paired plutonic belts at a high angle indicating extension was not the result of gravitational collapse, but more likely driven by plate boundary forces such as microplate capture as the dynamics of subduction along the continental

  7. Associations between statin use and non-Hodgkin lymphoma (NHL) risk and survival: a meta-analysis.

    Science.gov (United States)

    Ye, Xibiao; Mneina, Ayat; Johnston, James B; Mahmud, Salaheddin M

    2017-06-01

    Evidence on the effect of statin use on non-Hodgkin lymphoma (NHL) is not clear. We conducted a systematic review and meta-analysis to examine the associations between statin use and NHL risk and survival. We searched multiple literature sources up to October 2014 and identified 10 studies on the risk of diagnosis with NHL and 9 studies on survival. Random effects model was used to calculate pooled odds ratio (PORs) for risk and pooled hazard ratio (PHR) for survival. Heterogeneity among studies was examined using the Tau-squared and the I-squared (I(2) ) tests. Statin use was associated with reduced risk for total NHL (POR = 0.82, 95% CI 0.69-0.99). Among statin users, there was a lower incidence risk for marginal zone lymphoma (POR = 0.54, 95% CI 0.31-0.94), but this was not observed for other types of NHL. However, statin use did not affect overall survival (PHR = 1.02, 95% CI 0.99-1.06) or event-free survival (PHR = 0.99, 95% CI 0.87-1.12) in diffuse large B-cell lymphoma. There is suggestive epidemiological evidence that statins decrease the risk of NHL, but they do not influence survival in NHL patients. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

  8. Lymphoma in acquired generalized lipodystrophy.

    Science.gov (United States)

    Brown, Rebecca J; Chan, Jean L; Jaffe, Elaine S; Cochran, Elaine; DePaoli, Alex M; Gautier, Jean-Francois; Goujard, Cecile; Vigouroux, Corinne; Gorden, Phillip

    2016-01-01

    Acquired generalized lipodystrophy (AGL) is a rare disease thought to result from autoimmune destruction of adipose tissue. Peripheral T-cell lymphoma (PTCL) has been reported in two AGL patients. We report five additional cases of lymphoma in AGL, and analyze the role of underlying autoimmunity and recombinant human leptin (metreleptin) replacement in lymphoma development. Three patients developed lymphoma during metreleptin treatment (two PTCL and one ALK-positive anaplastic large cell lymphoma), and two developed lymphomas (mycosis fungoides and Burkitt lymphoma) without metreleptin. AGL is associated with high risk for lymphoma, especially PTCL. Autoimmunity likely contributes to this risk. Lymphoma developed with or without metreleptin, suggesting metreleptin does not directly cause lymphoma development; a theoretical role of metreleptin in lymphoma progression remains possible. For most patients with AGL and severe metabolic complications, the proven benefits of metreleptin on metabolic disease will likely outweigh theoretical risks of metreleptin in lymphoma development or progression.

  9. Pediatric lymphomas in Brazil

    Directory of Open Access Journals (Sweden)

    Gabriela Gualco

    2010-01-01

    Full Text Available OBJECTIVE: This study provides the clinical pathological characteristics of 1301 cases of pediatric/adolescent lymphomas in patients from different geographic regions of Brazil. METHODS: A retrospective analyses of diagnosed pediatric lymphoma cases in a 10-year period was performed. We believe that it represents the largest series of pediatric lymphomas presented from Brazil. RESULTS: Non-Hodgkin lymphomas represented 68% of the cases, including those of precursor (36% and mature (64% cell origin. Mature cell lymphomas comprised 81% of the B-cell phenotype and 19% of the T-cell phenotype. Hodgkin lymphomas represented 32% of all cases, including 87% of the classical type and 13% of nodular lymphocyte predominant type. The geographic distribution showed 38.4% of the cases in the Southeast region, 28.7% in the Northeast, 16.1% in the South, 8.8% in the North, and 8% in the Central-west region. The distribution by age groups was 15-18 years old, 33%; 11-14 years old, 26%; 6-10 years old, 24%; and 6 years old or younger, 17%. Among mature B-cell lymphomas, most of the cases were Burkitt lymphomas (65%, followed by diffuse large B-cell lymphomas (24%. In the mature T-cell group, anaplastic large cell lymphoma, ALK-positive was the most prevalent (57%, followed by peripheral T-cell lymphoma, then not otherwise specified (25%. In the group of classic Hodgkin lymphomas, the main histological subtype was nodular sclerosis (76%. Nodular lymphocyte predominance occurred more frequently than in other series. CONCLUSION: Some of the results found in this study may reflect the heterogeneous socioeconomical status and environmental factors of the Brazilian population in different regions.

  10. Lymphomas of large cells.

    Science.gov (United States)

    Staples, W G; Gétaz, E P

    1977-09-03

    Historial aspects of the classification of large-cell lymphomas are described. Immunological characterization of the lymphomas has been made possible by identification of T and B lymphocytes according to their cell membrane surface characteristics. The pathogenesis of lymphomas has been clarified by the germinal (follicular) centre cell concepts of Lennert and Lukes and Collins. The various classifications are presented and compared. Whether these subdivisions will have any relevance in the clinical context remains to be seen.

  11. Lymphoma Microenvironment and Immunotherapy.

    Science.gov (United States)

    Xu, Mina L; Fedoriw, Yuri

    2016-03-01

    Understanding of the lymphoma tumor microenvironment is poised to expand in the era of next-generation sequencing studies of the tumor cells themselves. Successful therapies of the future will rely on deeper appreciation of the interactions between elements of the microenvironment. Although the phenotypic, cytogenetic, and molecular characterization of tumor cells in lymphomas has progressed faster than most other solid organ tumors, concrete advancements in understanding the lymphoma microenvironment have been fewer. This article explores the composition of the lymphoma tumor microenvironment; its role in immune surveillance, evasion, and drug resistance; and its potential role in the development of targeted therapies. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Bilateral primary breast lymphoma

    Institute of Scientific and Technical Information of China (English)

    Jung Im Yi; Byung Joo Chae; Ja Seong Bae; Bong Joo Kang; Ahwon Lee; Byung Joo Song; Sang Seol Jung

    2010-01-01

    @@ Primary breast lymphoma (PBL) is rare, accounting for 0.04%-0.50% of breast malignancies and 1.7% of extranodal lymphoma.1,2 The originally described diagnostic criteria for PBL2 remains the standard definition for this disease. These criteria are breast location as the clinical site of presentation, absence of history of previous lymphoma or evidence of widespread disease at diagnosis, close association of lymphoma with breast tissue in pathologic specimens, and involvement of ipsilateral lymph nodes if they develop simultaneously with PBL.

  13. Primary gastrointestinal lymphoma

    Institute of Scientific and Technical Information of China (English)

    Prasanna Ghimire; Guang-Yao Wu; Ling Zhu

    2011-01-01

    Gastrointestinal tract is the most common extranodal site involved by lymphoma with the majority being non-Hodgkin type. Although lymphoma can involve any part of the gastrointestinal tract, the most frequent sites in order of its occurrence are the stomach followed by small intestine and ileocecal region. Gastrointestinal tract lymphoma is usually secondary to the widespread nodal diseases and primary gastrointestinal tract lymphoma is relatively rare. Gastrointestinal lymphomas are usually not clinically specific and indistinguishable from other benign and malignant conditions. Diffuse large B-cell lymphoma is the most common pathological type of gastrointestinal lymphoma in essentially all sites of the gastrointestinal tract, although recently the frequency of other forms has also increased in certain regions of the world. Although some radiological features such as bulky lymph nodes and maintenance of fat plane are more suggestive of lymphoma, they are not specific,thus mandating histopathological analysis for its definitive diagnosis. There has been a tremendous leap in the diagnosis, staging and management of gastrointestinal lymphoma in the last two decades attributed to a better insight into its etiology and molecular aspect as well as the knowledge about its critical signaling pathways.

  14. Bilateral Primary Intraocular Lymphoma

    Directory of Open Access Journals (Sweden)

    Mehrdad Karimi

    2011-01-01

    Full Text Available Purpose: To report a case of bilateral primary intraocular lymphoma. Case report: A 33-year-old man presented with bilateral blurred vision since two years ago. Examination revealed large keratic precipitates, anterior chamber reaction, posterior subcapsular cataracts, and vitreous infiltration. After a short trial of topical and periocular steroids, diagnostic 25-gauge pars plana vitrectomy was performed and cytologic evaluation of the aspirate confirmed a diagnosis of intraocular lymphoma. The patient was subsequently managed with intravitreal methotrexate in both eyes and responded favorably. Central nervous system workup for lymphoma was negative. Conclusion: Primary intraocular lymphoma should be considered in young adults suffering from chronic recalcitrant panuveitis.

  15. Margin requirements, margin loans, and margin rates: practice and principles

    OpenAIRE

    Peter Fortune

    2000-01-01

    The Board of Governors of the Federal Reserve System establishes initial margin requirements under Regulations T, U, and X. Recent margin loan increases, both in aggregate value and relative to market capitalization, have rekindled the debate about using margin requirements as an instrument to affect the prices of common stocks. Proponents of a more active margin requirement policy see the regulations as instruments for affecting the level and volatility of stock prices by influencing investo...

  16. [Molecular abnormalities in lymphomas].

    Science.gov (United States)

    Delsol, G

    2010-11-01

    Numerous molecular abnormalities have been described in lymphomas. They are of diagnostic and prognostic value and are taken into account for the WHO classification of these tumors. They also shed some light on the underlying molecular mechanisms involved in lymphomas. Overall, four types of molecular abnormalities are involved: mutations, translocations, amplifications and deletions of tumor suppressor genes. Several techniques are available to detect these molecular anomalies: conventional cytogenetic analysis, multicolor FISH, CGH array or gene expression profiling using DNA microarrays. In some lymphomas, genetic abnormalities are responsible for the expression of an abnormal protein (e.g. tyrosine-kinase, transcription factor) detectable by immunohistochemistry. In the present review, molecular abnormalities observed in the most frequent B, T or NK cell lymphomas are discussed. In the broad spectrum of diffuse large B-cell lymphomas microarray analysis shows mostly two subgroups of tumors, one with gene expression signature corresponding to germinal center B-cell-like (GCB: CD10+, BCL6 [B-Cell Lymphoma 6]+, centerine+, MUM1-) and a subgroup expressing an activated B-cell-like signature (ABC: CD10-, BCL6-, centerine-, MUM1+). Among other B-cell lymphomas with well characterized molecular abnormalies are follicular lymphoma (BCL2 deregulation), MALT lymphoma (Mucosa Associated Lymphoid Tissue) [API2-MALT1 (mucosa-associated-lymphoid-tissue-lymphoma-translocation-gene1) fusion protein or deregulation BCL10, MALT1, FOXP1. MALT1 transcription factors], mantle cell lymphoma (cycline D1 [CCND1] overexpression) and Burkitt lymphoma (c-Myc expression). Except for ALK (anaplastic lymphoma kinase)-positive anaplastic large cell lymphoma, well characterized molecular anomalies are rare in lymphomas developed from T or NK cells. Peripheral T cell lymphomas not otherwise specified are a heterogeneous group of tumors with frequent but not recurrent molecular abnormalities

  17. Benign lymphoepithelial lesion,lymphoepithelial carcinoma,MALT lymphoma and their association%良性淋巴上皮病、淋巴上皮癌、MALT淋巴瘤的关系

    Institute of Scientific and Technical Information of China (English)

    李江

    2007-01-01

    良性淋巴上皮病(benign lymphoepithelial lesion)、淋巴上皮癌(lymphoepithelial carcinoma)、黏膜相关淋巴组织型结外边缘区B细胞淋巴瘤(MALT淋巴瘤)(extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoidtissue,MALT lymphoma)是3种性质不同但又存在某些关联的病变,本文对3种病变的病因、组织病理学表现及三者之间的关系进行了介绍,并结合叶为民等论文中的一些内容进行了简要探讨.

  18. Sarcoidosis Occurring After Lymphoma

    Science.gov (United States)

    London, Jonathan; Grados, Aurélie; Fermé, Christophe; Charmillon, Alexandre; Maurier, François; Deau, Bénédicte; Crickx, Etienne; Brice, Pauline; Chapelon-Abric, Catherine; Haioun, Corinne; Burroni, Barbara; Alifano, Marco; Le Jeunne, Claire; Guillevin, Loïc; Costedoat-Chalumeau, Nathalie; Schleinitz, Nicolas; Mouthon, Luc; Terrier, Benjamin

    2014-01-01

    Abstract Sarcoidosis is a granulomatous disease that most frequently affects the lungs with pulmonary infiltrates and/or bilateral hilar and mediastinal lymphadenopathy. An association of sarcoidosis and lymphoproliferative disease has previously been reported as the sarcoidosis-lymphoma syndrome. Although this syndrome is characterized by sarcoidosis preceding lymphoma, very few cases of sarcoidosis following lymphoma have been reported. We describe the clinical, biological, and radiological characteristics and outcome of 39 patients presenting with sarcoidosis following lymphoproliferative disease, including 14 previously unreported cases and 25 additional patients, after performing a literature review. Hodgkin lymphoma and non-Hodgkin lymphoma were equally represented. The median delay between lymphoma and sarcoidosis was 18 months. Only 16 patients (41%) required treatment. Sarcoidosis was of mild intensity or self-healing in most cases, and overall clinical response to sarcoidosis was excellent with complete clinical response in 91% of patients. Sarcoidosis was identified after a follow-up computerized tomography scan (CT-scan) or 18fluorodeoxyglucose-positron emission tomography/computerized tomography (18FDG-PET/CT) evaluation in 18/34 patients (53%). Sarcoidosis is therefore a differential diagnosis to consider when lymphoma relapse is suspected on a CT-scan or 18FDG-PET/CT, emphasizing the necessity to rely on histological confirmation of lymphoma relapse. PMID:25380084

  19. Biomarkers for lymphoma

    Science.gov (United States)

    Zangar, Richard C.; Varnum, Susan M.

    2014-09-02

    A biomarker, method, test kit, and diagnostic system for detecting the presence of lymphoma in a person are disclosed. The lymphoma may be Hodgkin's lymphoma or non-Hodgkin's lymphoma. The person may be a high-risk subject. In one embodiment, a plasma sample from a person is obtained. The level of at least one protein listed in Table S3 in the plasma sample is measured. The level of at least one protein in the plasma sample is compared with the level in a normal or healthy subject. The lymphoma is diagnosed based upon the level of the at least one protein in the plasma sample in comparison to the normal or healthy level.

  20. [Secondary orbital lymphoma].

    Science.gov (United States)

    Basanta, I; Sevillano, C; Álvarez, M D

    2015-09-01

    A case is presented of an 85 year-old Caucasian female with lymphoma that recurred in the orbit (secondary ocular adnexal lymphoma). The orbital tumour was a diffuse large B-cell lymphoma according to the REAL classification (Revised European-American Lymphoma Classification). Orbital lymphomas are predominantly B-cell proliferations of a variety of histological types, and most are low-grade tumours. Patients are usually middle-aged or elderly, and it is slightly more common in women. A palpable mass, proptosis and blepharoptosis are the most common signs of presentation. Copyright © 2011 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.

  1. Antibody response against Betaferon® in immune tolerant mice: involvement of marginal zone B-cells and CD4+ T-cells and apparent lack of immunological memory.

    Science.gov (United States)

    Sauerborn, Melody; van Beers, Miranda M C; Jiskoot, Wim; Kijanka, Grzegorz M; Boon, Louis; Schellekens, Huub; Brinks, Vera

    2013-01-01

    The immunological processes underlying immunogenicity of recombinant human therapeutics are poorly understood. Using an immune tolerant mouse model we previously demonstrated that aggregates are a major trigger of the antidrug antibody (ADA) response against recombinant human interferon beta (rhIFNβ) products including Betaferon®, and that immunological memory seems to be lacking after a rechallenge with non-aggregated rhIFNβ. The apparent absence of immunological memory indicates a CD4+ T-cell independent (Tind) immune response underlying ADA formation against Betaferon®. This hypothesis was tested. Using the immune tolerant mouse model we first validated that rechallenge with highly aggregated rhIFNβ (Betaferon®) does not lead to a subsequent fast increase in ADA titers, suggesting a lack of immunological memory. Next we assessed whether Betaferon® could act as Tind antigen by inactivation of marginal zone (MZ) B-cells during treatment. MZ B-cells are major effector cells involved in a Tind immune response. In a following experiment we depleted the mice from CD4+ T-cells to test their involvement in the ADA response against Betaferon®. Inactivation of MZ B-cells at the start of Betaferon® treatment drastically lowered ADA levels, suggesting a Tind immune response. However, persistent depletion of CD4+ T-cells before and during Betaferon® treatment abolished the ADA response in almost all mice. The immune response against rhIFNβ in immune tolerant mice is neither a T-cell independent nor a classical T-cell dependent immune response. Further studies are needed to confirm absence of immunological memory (cells).

  2. Angioimmunoblastic T-Cell Lymphoma

    Science.gov (United States)

    Angioimmunoblastic T-Cell Lymphoma Overview Lymphoma is the most common blood cancer. The two main forms of lymphoma are ... develop into lymphomas: B-lymphocytes (B-cells) and T-lymphocytes (T-cells). Cancerous lymphocytes can travel to ...

  3. Primary Gallbladder Lymphoma in a Male Patient with No Risk Factors Detected Incidentally by CT Colonography

    Directory of Open Access Journals (Sweden)

    Monil Karia

    2015-01-01

    Full Text Available Primary gallbladder lymphoma, although rare, usually presents in females with symptoms mimicking cholecystitis. We present a rare case of primary gallbladder in an 81-year-old male with no risk factors whose only symptom was weight loss. Routine blood tests including liver function tests were unremarkable. A CT colonography was carried out to exclude colonic malignancy. Unilateral gallbladder wall thickening and lymphadenopathy were incidentally detected and confirmed by ultrasound and a decision for the patient to undergo laparoscopic cholecystectomy and intraoperative cholangiogram was made. Histology confirmed extranodal marginal zone lymphoma with follow-up staging and biopsy of the bone marrow not demonstrating spread. Cholecystectomy was therefore deemed curative and no adjuvant therapy was necessary. Thickening of the gallbladder wall on any imaging with or without symptoms should not be ignored or assumed to be cholecystitis, even in males with no risk factors. In these patients urgent cholecystectomy with intraoperative cholangiogram is indicated with histology and haematology follow-up.

  4. Clinicopathologic features of gastrointestinal schwannomas coexisting extranodal marginal zone lympoma of mucosa associated lymphoid tissue lymphoma of rectum%直肠碰撞瘤临床病理观察

    Institute of Scientific and Technical Information of China (English)

    崔华娟; 王卓才; 赖日权; 彭大云; 陈敬文

    2013-01-01

    目的 提高对直肠碰撞瘤的认识.方法 对1例直肠胃肠神经鞘瘤与黏膜相关淋巴组织结外边缘区B细胞性淋巴瘤(MALT)形成的碰撞瘤,进行组织形态学观察及免疫组化检测,并复习相关文献.结果 患者女性,65岁.体检发现下腹部肿块.CT提示直肠右侧壁可见2.8 cm ×1.9 cm大小软组织影,邻近直肠管腔受压变窄.在直肠肿瘤切除标本中,同一肿物内可见胃肠神经鞘瘤和MALT淋巴瘤2种成分.2种肿瘤成分界限清楚,形成碰撞瘤,其中淋巴瘤成分包裹神经鞘瘤.神经鞘瘤S-100、PDG9.5、nestin和GFAP(-);淋巴瘤LCA、CD20和CD79α(+),CD3和CD45RO(-).基因重排显示B细胞单克隆性增生.IgH/MALT1 t(14;18) (q32;q21)及API2/MALT1 t(11;18) (q21;q21)染色体异位(-).c-kit及PDGFRA基因均为野生型.结论 直肠胃肠神经鞘瘤与淋巴瘤形成的碰撞瘤罕见.应与胃肠间质瘤及淋巴组织反应性增生鉴别.

  5. Learning About Intervention Target Zones

    OpenAIRE

    Klein, Michael W; Karen K. Lewis

    1991-01-01

    This paper provides a framework for evaluating how market participants' beliefs about foreign exchange target zones change as they learn about central bank intervention policy. In order to examine this behavior, we first generalize the standard target zone model to allow for intra-marginal intervention. Intra-marginal intervention implies that the position of market participants' beliefs about the target zone can be determined from their beliefs about the likelihood of intervention. As an app...

  6. Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma

    Directory of Open Access Journals (Sweden)

    Blix Egil S

    2012-10-01

    Full Text Available Abstract Background Knowledge about signaling pathways in malignant cells may provide prognostic and diagnostic information in addition to identify potential molecular targets for therapy. B-cell receptor (BCR and co-receptor CD40 signaling is essential for normal B cells, and there is increasing evidence that signaling via BCR and CD40 plays an important role in the pathogenesis of B-cell lymphoma. The aim of this study was to investigate basal and induced signaling in lymphoma B cells and infiltrating T cells in single-cell suspensions of biopsies from small cell lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL and marginal zone lymphoma (MZL patients. Methods Samples from untreated SLL/CLL and MZL patients were examined for basal and activation induced signaling by phospho-specific flow cytometry. A panel of 9 stimulation conditions targeting B and T cells, including crosslinking of the B cell receptor (BCR, CD40 ligand and interleukins in combination with 12 matching phospho-protein readouts was used to study signaling. Results Malignant B cells from SLL/CLL patients had higher basal levels of phosphorylated (p-SFKs, p-PLCγ, p-ERK, p-p38, p-p65 (NF-κB, p-STAT5 and p-STAT6, compared to healthy donor B cells. In contrast, anti-BCR induced signaling was highly impaired in SLL/CLL and MZL B cells as determined by low p-SFK, p-SYK and p-PLCγ levels. Impaired anti-BCR-induced p-PLCγ was associated with reduced surface expression of IgM and CD79b. Similarly, CD40L-induced p-ERK and p-p38 were also significantly reduced in lymphoma B cells, whereas p-p65 (NF-κB was equal to that of normal B cells. In contrast, IL-2, IL-7 and IL-15 induced p-STAT5 in tumor-infiltrating T cells were not different from normal T cells. Conclusions BCR signaling and CD40L-induced p-p38 was suppressed in malignant B cells from SLL/CLL and MZL patients. Single-cell phospho-specific flow cytometry for detection of basal as well as activation

  7. Primary pediatric gastrointestinal lymphoma

    Directory of Open Access Journals (Sweden)

    Ranjana Bandyopadhyay

    2011-01-01

    Full Text Available Background: Primary non-Hodgkin′s lymphoma (NHL of the gastrointestinal (GI tract is the most common extranodal lymphoma in pediatric age group. Yet, the overall incidence is very low. The rarity of the disease as well as variable clinical presentation prevents early detection when the possibility of cure exists. Materials and Methods: We studied six cases of primary GI NHL in pediatric age group with reference to their clinical presentation, anatomic distribution and histopathologic characteristics. Results: All were males except one. Intestinal obstruction was the presenting feature in 50%. Half the cases showed ileocaecal involvement, while large bowel was involved in 16%. Histology showed four cases of diffuse large B-cell lymphoma (DLBCL, one case of Burkitt lymphoma, and one Burkitt-like lymphoma. Immunohistochemistry for Tdt, CD20, CD3, CD30, bcl2, bcl6 confirmed the morphological diagnosis. Conclusion: Pediatric GI lymphoma commonly involves the ileocaecal region and presents with intestinal obstruction. A higher prevalence of DLBCL is found compared to other series. A high proliferative index is useful in differentiating Burkitt-like lymphoma from DLBCL.

  8. Primary leptomeningeal lymphoma

    Science.gov (United States)

    Taylor, Jennie W.; Flanagan, Eoin P.; O'Neill, Brian P.; Siegal, Tali; Omuro, Antonio; DeAngelis, Lisa; Baehring, Joachim; Nishikawa, Ryo; Pinto, Fernando; Chamberlain, Marc; Hoang-Xuan, Khe; Gonzalez-Aguilar, Alberto; Batchelor, Tracy; Blay, Jean-Yves; Korfel, Agnieszka; Betensky, Rebecca A.; Lopes, Maria-Beatriz S.

    2013-01-01

    Objective: To evaluate clinical presentation, optimal diagnostic evaluation and treatment, and outcome in primary leptomeningeal lymphoma, a rare form of primary CNS lymphoma without parenchymal or systemic involvement. Methods: The International Primary CNS Lymphoma Collaborative Group, a multidisciplinary group of physicians with a particular interest in primary CNS lymphoma, retrospectively identified cases of lymphoma isolated to the leptomeninges as diagnosed by CSF cytology, flow cytometry, or biopsy, without systemic or parenchymal brain/spinal cord lymphoma or immunodeficiency. Results: Forty-eight patients were identified, with median age at diagnosis of 51 years and median Eastern Cooperative Oncology Group performance status of 2. Presenting symptoms were multifocal in 68%. Leptomeningeal enhancement was seen in 74% and CSF profile was abnormal in all cases. CSF cytology detected malignant lymphocytes in 67%. Flow cytometry identified monoclonal population in 80%, as did receptor gene rearrangement studies in 71%. Sixty-two percent had B-cell lymphoma, 19% T-cell, and 19% unclassified. Treatment varied and included fractionated radiotherapy (36%), systemic chemotherapy (78%), and intra-CSF chemotherapy (66%), with 66% receiving ≥2 modalities. Seventy-one percent had a favorable clinical response; ultimately, 44% received salvage treatment. Median overall survival was 24 months, with 11 patients still alive at 50 months follow-up. Conclusion: Primary leptomeningeal lymphoma is a rare form of primary CNS lymphoma. Patients usually present with multifocal symptoms, with evidence of leptomeningeal enhancement and diagnostic CSF analysis. Although treatment is highly variable, patients have a better prognosis than previously reported and a subset may be cured. PMID:24107866

  9. Radiotherapy for Hodgkin lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Specht, Lena [Rigshospitalet Copenhagen Univ. (Denmark). Depts. of Oncology and Haematology; Yahalom, Joachim (eds.) [Memorial Sloan-Kettering Cancer, New York, NY (United States). Dept. of Radiation Oncology

    2011-07-01

    This book deals in detail with all aspects of the best practice in modern radiotherapy for Hodgkin lymphoma. It provides the background and rationale for the inclusion of radiotherapy in today's combined-modality approach, including special clinical situations such as Hodgkin lymphoma in children, in the pregnant patient, and in the elderly. Radiotherapy planning using state-of-the-art imaging, target definition, planning software, and treatment equipment is expounded in detail. Acute and long-term side effects of radiotherapy are analyzed, and the implications for modern radiotherapy approaches in Hodgkin lymphomas are explained. (orig.)

  10. Primary renal mucosa-associated lymphoid tissue lymphoma,the result of chronic pyelonephritis?%肾脏黏膜相关淋巴瘤,是慢性肾孟肾炎的后果吗?

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Objective:To report 2 cases of primary renal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma), and observe the relations between this rare tumor of kidney and chronic pyelonephritis. Methods: 2renal MALT lymphomas were collected from referral consultation. Detailed clinical information were reviewed, morphological analysis based on the HE section, and immunohistochemistry were performed by CD20, CD79a, CDS, CD10, CD43, CD23,BCL10 and Cyclin D1 antibodies. Results: 2 female patients with age of 48 and 55, respectively, all had a history of chronic pyelonephritis. Under the B ultrasonic and CT scanning a bump in the kidney was found. Renal carcinoma suspected and hereby the whole nephrectomy performed. In the macroscopic, tumors were laid in the renal medulla, with dark red color and ill-defined boundary. In the microscopic, there were mixed lymphoid cells infiltrate which mainly consisted of small lymphocytes, centrocyte-like cells, lymphoplasmacytoid and plasma cells, reactive follicles and lymphoepithelial lesions also could be seen in the lesion, but follicles colonization was rare. In fact, except changes of lymphoma, basic renal disease also could be seen. Most glomeruli were atrophic, some glomeruli were hyperplastic and hypertrophic. Tubules were dilated or contacted, many dilated tubules contained pink-color glassy-appearing casts that suggest the appearance of thyroid tissue.As a result, those 2 cases showed juxtaposed changes of lymphoma and pyelonephritis. Immunohistochemistry showed that tumor cells were CD20 and CD79a positive, CD43 was weak positive, but CD5, CD10, CD23, BCL10 and Cyclin D1 were all negative. Conclusion: Primary renal MALT lymphoma was very rare disease. According to the clinical manifestation, it's hard to differentiate from renal cell carcinoma. But the morphological features were consistent with the classic MALT lymphomas in other sites. Immunophenotypic profiles were helpful for diagnosis. Based

  11. Treatment Options for Adult Hodgkin Lymphoma

    Science.gov (United States)

    ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ...

  12. General Information about AIDS-Related Lymphoma

    Science.gov (United States)

    ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ...

  13. General Information about Adult Hodgkin Lymphoma

    Science.gov (United States)

    ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ...

  14. Treatment Options for AIDS-Related Lymphoma

    Science.gov (United States)

    ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ...

  15. Treatment Option Overview (Childhood Hodgkin Lymphoma)

    Science.gov (United States)

    ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ...

  16. Treatment Option Overview (Adult Hodgkin Lymphoma)

    Science.gov (United States)

    ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ...

  17. Stages of Childhood Non-Hodgkin Lymphoma

    Science.gov (United States)

    ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ...

  18. Treatment Options for Hodgkin Lymphoma during Pregnancy

    Science.gov (United States)

    ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ...

  19. Non-Hodgkin Lymphoma (For Parents)

    Science.gov (United States)

    ... Kids to Be Smart About Social Media Non-Hodgkin Lymphoma KidsHealth > For Parents > Non-Hodgkin Lymphoma Print ... harmful things out of the body. About Non-Hodgkin Lymphoma No n-Hodgkin lymphoma is a disease ...

  20. A case of mucosa-associated lymphoid tissue lymphoma forming multiple lymphomatous polyposis in the small intestine

    Institute of Scientific and Technical Information of China (English)

    Naoto Hirata; Shiro Nakamura; Nobuhide Oshitani; Kazuhide Higuchi; Tetsuo Arakawa; Kazunari Tominaga; Kensuke Ohta; Kaori Kadouchi; Hirotoshi Okazaki; Tetsuya Tanigawa; Masatsugu Shiba; Toshio Watanabe; Yasuhiro Fujiwara

    2007-01-01

    A 50-year old woman suffering from diabetes had a CT scan that revealed a diffuse thickening of small intestinal wall and swollen paraaortic lymph nodes. An esophago gastroduodenoscopy (EGD) confirmed multiple polypoid lesions in the duodenum and small intestine, and conventional histological testing revealed non-specific inflammatory changes. Further examinations including the immunohistochemical profiles of the biopsied specimens led us to diagnose the lesion as a marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type, forming multiple lymphomatous polyposis sequentially spreading from duodenal bulb to terminal ileum. According to Lugano's classification, its staging was clinically diagnosed as stage Ⅱ. Two courses of a standard CHOP (cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and predonisolone)regimen with rituximab reduced the lesion and the patient had a almost complete response. A 5-year follow-up EGD and histological examinations detected no recurrence of the disease.

  1. Lymphoma Research Foundation

    Science.gov (United States)

    ... the stem cell transplantation process. Read More LYMPHOMA RESEARCH Featured Researcher – David Scott, MBChB, PhD Dr. Scott ... and Advocacy News Action Center Advocacy Tool Kit Research LRF Research Portfolio Disease-Specific Focus Areas Grants ...

  2. Uptake of algal carbon and the synthesis of an "essential" fatty acid by Uvigerina ex. gr. semiornata (Foraminifera within the Pakistan margin oxygen minimum zone: evidence from fatty acid biomarker and 13C tracer experiments

    Directory of Open Access Journals (Sweden)

    K. E. Larkin

    2014-01-01

    Full Text Available Foraminifera are an important component of benthic communities in oxygen depleted settings, where they potentially play a~significant role in the processing of organic matter. We tracked the uptake of a 13C-labeled algal food source into individual fatty acids in the benthic foraminiferal species, Uvigerina ex. gr. semiornata, from the Arabian Sea oxygen minimum zone (OMZ. The tracer experiments were conducted on the Pakistan Margin during the late/post monsoon period (August–October 2003. A monoculture of the diatom Thalassiosira weisflogii was 13C-labeled and used to simulate a pulse of phytoplankton in two complementary experiments. A lander system was used for in situ incubations at 140 m and for 2.5 days duration, whilst a laboratory incubation used an oxystat system to maintain ambient dissolved oxygen concentrations. These shipboard experiments were terminated after 5 days. Uptake of diatoms was rapid, with high incorporation of diatom fatty acids into foraminifera after ~2 days in both experiments. Ingestion of the diatom food source was indicated by the increase over time in the quantity of diatom biomarker fatty acids in the foraminifera and by the high percentage of 13C in many of the fatty acids present at the endpoint of both in~situ and laboratory-based experiments. These results indicate that U. ex. gr. semiornata rapidly ingested the diatom food source and that this foraminifera will play an important role in the short-term cycling of organic matter within this OMZ environment. The experiments also suggested that U. ex. gr. semiornata consumed non-labeled bacterial food items, particularly bacteria, and synthesised the polyunsaturated fatty acid 20:4(n-6 de novo. 20:4(n-6 is often abundant in benthic fauna yet its origins and function have remained unclear. This study demonstrates that U. ex. gr. semiornata is capable of de novo synthesis of this "essential fatty acid" and is potentially a major source of this dietary nutrient

  3. 夏季加拿大海盆海冰边缘区声体积后向散射强度研究%Study on volume backscattering strength in summer marginal ice zone of Canada Basin

    Institute of Scientific and Technical Information of China (English)

    刘洪宁; 吕连港; 刘娜; 杨光兵; 姜莹; 杨春梅; 刘宗伟; 林丽娜

    2015-01-01

    Volume backscatter strength (Sv)is a key parameter for acoustic transmission.Study on volume back-scattering strength in marginal ice zone (MIZ)in the Arctic plays an important role in the knowledge of the Arctic acoustic environment.Based on the investigation during the Sixth Chinese National Arctic Research Expedition in summer 2014,the characteristics of backscatter strength in MIZ are analyzed.The results show that Sv under the open water (ice concentration less than 15%)is significantly higher than that in seawater under the packed ice (ice concentration more than 50%).Ice melt causes increasing of opaque creatures and suspended sediment,and leads to increase of Sv.According to the characteristics of low Sv under the packed ice,the proposal about the parameters of LADCP setting is given.%声信号的体积后向散射强度是声传播过程中一个关键的参数。海冰边缘区的声体积后向散射强度研究对深入认识北极声场环境有着十分重要的意义。本文利用中国第六次北极科学考察获取的数据资料研究了海冰边缘区声体积后向散射强度特性。结果表明:加拿大海盆海冰边缘区是声体积后向散射强度的明显过渡区。无冰海面(海冰密集度小于15%)海洋深层水的声体积后向散射强度明显大于密集海冰区域的海水(海冰密集度大于50%)。讨论了声体积后向散射强度与海冰融化之间的关系,造成融冰区声体积后向散射强度增大的原因是水下悬浮泥沙、浮游生物等悬浮物质增加。根据海冰密集海域的海水后向散射强度弱的特点,对北极下放式声学多普勒测流仪(LADCP)观测的设置提出建议。

  4. Short-term sea ice forecasts with the RASM-ESRL coupled model: A testbed for improving simulations of ocean-ice-atmosphere interactions in the marginal ice zone

    Science.gov (United States)

    Solomon, A.; Cox, C. J.; Hughes, M.; Intrieri, J. M.; Persson, O. P. G.

    2015-12-01

    The dramatic decrease of Arctic sea-ice has led to a new Arctic sea-ice paradigm and to increased commercial activity in the Arctic Ocean. NOAA's mission to provide accurate and timely sea-ice forecasts, as explicitly outlined in the National Ocean Policy and the U.S. National Strategy for the Arctic Region, needs significant improvement across a range of time scales to improve safety for human activity. Unfortunately, the sea-ice evolution in the new Arctic involves the interaction of numerous physical processes in the atmosphere, ice, and ocean, some of which are not yet understood. These include atmospheric forcing of sea-ice movement through stress and stress deformation; atmospheric forcing of sea-ice melt and formation through energy fluxes; and ocean forcing of the atmosphere through new regions of seasonal heat release. Many of these interactions involve emerging complex processes that first need to be understood and then incorporated into forecast models in order to realize the goal of useful sea-ice forecasting. The underlying hypothesis for this study is that errors in simulations of "fast" atmospheric processes significantly impact the forecast of seasonal sea-ice retreat in summer and its advance in autumn in the marginal ice zone (MIZ). We therefore focus on short-term (0-20 day) ice-floe movement, the freeze-up and melt-back processes in the MIZ, and the role of storms in modulating stress and heat fluxes. This study uses a coupled ocean-atmosphere-seaice forecast model as a testbed to investigate; whether ocean-sea ice-atmosphere coupling improves forecasts on subseasonal time scales, where systematic biases develop due to inadequate parameterizations (focusing on mixed-phase clouds and surface fluxes), how increased atmospheric resolution of synoptic features improves the forecasts, and how initialization of sea ice area and thickness and snow depth impacts the skill of the forecasts. Simulations are validated with measurements at pan-Arctic land

  5. Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma.

    Science.gov (United States)

    Li, Pei Chuan; Siddiqi, Imran N; Mottok, Anja; Loo, Eric Y; Wu, Chieh Hsi; Cozen, Wendy; Steidl, Christian; Shih, Jean Chen

    2017-10-01

    Monoamine oxidase A (MAOA) is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and dietary amines and produces H2 O2 . It facilitates the progression of gliomas and prostate cancer, but its expression and functional relevance have not been studied in lymphoma. Here, we evaluated MAOA in 427 cases of Hodgkin and non-Hodgkin lymphoma and in a spectrum of reactive lymphoid tissues by immunohistochemistry on formalin-fixed, paraffin-embedded specimens. MAOA was expressed by Hodgkin Reed-Sternberg (HRS) cells in the majority of classical Hodgkin lymphomas (cHLs) (181/241; 75%), with 34.8% showing strong expression. Weak MAOA was also noted in a minority of primary mediastinal large B-cell lymphomas (8/47; 17%) and in a mediastinal gray-zone lymphoma. In contrast, no MAOA was found in non-neoplastic lymphoid tissues, nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL; 0/8) or any other non-Hodgkin lymphomas studied (0/123). MAOA was more common in Epstein-Barr virus (EBV)-negative compared to EBV-positive cHL (p Hodgkin-lymphoma-derived cell lines did not. The MAOA inhibitor clorgyline reduced the growth of L1236 cells and U-HO1 cells, and shRNA knockdown of MAOA reduced the growth of L1236 cells. Conversely, ectopic overexpression of MAOA increased the growth of MAOA-negative HDLM2 cells. Combined treatment with clorgyline and ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) was more effective in reducing cell growth than either regimen alone. In summary, MAOA is highly expressed in cHL and may reflect the distinct biology of this lymphoma. Further studies on the potential utility of MAOA as a diagnostic marker and therapeutic target are warranted. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

  6. General Information about Adult Non-Hodgkin Lymphoma

    Science.gov (United States)

    ... Lymphoma Treatment AIDS-Related Lymphoma Treatment Chronic Lymphocytic Leukemia Treatment (small lymphocytic lymphoma) Mycosis Fungoides (Including Sézary Syndrome) Treatment (cutaneous T-cell lymphoma) Primary CNS Lymphoma Treatment Non-Hodgkin lymphoma ...

  7. Treatment Option Overview (Adult Non-Hodgkin Lymphoma)

    Science.gov (United States)

    ... Lymphoma Treatment AIDS-Related Lymphoma Treatment Chronic Lymphocytic Leukemia Treatment (small lymphocytic lymphoma) Mycosis Fungoides (Including Sézary Syndrome) Treatment (cutaneous T-cell lymphoma) Primary CNS Lymphoma Treatment Non-Hodgkin lymphoma ...

  8. [Central nervous system relapse in diffuse large B cell lymphoma: Risk factors].

    Science.gov (United States)

    Sancho, Juan-Manuel; Ribera, Josep-Maria

    2016-01-15

    Central nervous system (CNS) involvement by lymphoma is a complication associated, almost invariably, with a poor prognosis. The knowledge of the risk factors for CNS relapse is important to determine which patients could benefit from prophylaxis. Thus, patients with very aggressive lymphomas (such as lymphoblastic lymphoma or Burkitt's lymphoma) must systematically receive CNS prophylaxis due to a high CNS relapse rate (25-30%), while in patients with indolent lymphoma (such as follicular lymphoma or marginal lymphoma) prophylaxis is unnecessary. However, the question about CNS prophylaxis in patients with diffuse large B-cell lymphoma (DLBCL), the most common type of lymphoma, remains controversial. The information available is extensive, mainly based on retrospective and heterogeneous studies. There seems that immunochemotherapy based on rituximab reduces the CNS relapse rate. On the other hand, patients with increased serum lactate dehydrogenase plus more than one extranodal involvement seem to have a higher risk of CNS relapse, but a prophylaxis strategy based only on the presence of these 2 factors does not prevent all CNS relapses. Patients with involvement of testes or breast have high risk of CNS relapse and prophylaxis is mandatory. Finally, CNS prophylaxis could be considered in patients with DLBCL and renal or epidural space involvement, as well as in those cases with MYC rearrangements, although additional studies are necessary. Copyright © 2015 Elsevier España, S.L.U. All rights reserved.

  9. Drugs Approved for Hodgkin Lymphoma

    Science.gov (United States)

    ... Ask about Your Treatment Research Drugs Approved for Hodgkin Lymphoma This page lists cancer drugs approved by ... that are not listed here. Drugs Approved for Hodgkin Lymphoma Adcetris (Brentuximab Vedotin) Ambochlorin (Chlorambucil) Amboclorin (Chlorambucil) ...

  10. 443例恶性淋巴瘤临床病理特征分析%Clinical and pathological analysis of 443 cases with malignant lymphoma

    Institute of Scientific and Technical Information of China (English)

    吴永芳; 许春伟; 韩鸿雁; 王海艳; 邵云; 张博; 李晓兵; 苏航; 张伟京

    2015-01-01

    malignant lymphoma, Hodgkin’s lymphoma was 11.06%(49/443)and non-Hodgkin’s lymphoma was 88.94%(394/443). Among non-Hodgkin’s lymphoma, B cell lymphoma was 66.37%(294/443) and T cell lymphoma was 22.35%(99/443). The commonest subtypes were diffuse large B-cell lymphoma 41.53%(184/443), follicular lymphoma 11.06%(49/443), peripheral T-cell lymphoma 5.65%(25/443), T leukaemia/lymphoblastic lymphoma 5.19%(23/443), extranodal marginal zone B-cell lymphoma of MALT type 4.74%(21/443). Nodular sclerosis classical Hodgkin’s lymphoma was the commonest pathological type of Hodgkin′s lymphoma (4.51%, 20/443). hTe ratio of male to female was 1.58:1. hTe mean age at presentation was 57 years (range, 7~94 years). hTe lymph nodes of the cervical region were most commonly involved. hTe lymph nodes of the cervical region were most commonly involved. Conclusion:Of 443 cases of malignant lymphoma, diffuse large B-cell lymphoma is the commonest subtype of non-Hodgkin’s lymphoma, and Nodular sclerosis classical Hodgkin’s lymphoma is the commonest subtype of Hodgkin’s lymphoma. Most subtypes show a male predominance with most commonly affected in cervical lymphnodes.

  11. Intravascular large B cell lymphoma

    Directory of Open Access Journals (Sweden)

    Ricardo García-Muñoz

    2014-01-01

    Full Text Available Intravascular large B cell lymphoma (IVBCL is a rare type of extranodal large B cell lymphoma characterized by selective growth of lymphoma cells within the microvasculature. We present an illustrative case of intravascular B cell lymphoma suspected by the presence of a very small monoclonal B cell population identified by immunophenotype and polymerase chain reaction in bone marrow. The diagnosis was confirmed by skin biopsy.

  12. Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia

    Science.gov (United States)

    2013-07-10

    Adult Acute Lymphoblastic Leukemia; Adult Acute Myeloid Leukemia; Adult Burkitt Lymphoma; Adult Diffuse Large Cell Lymphoma; Adult Diffuse Mixed Cell Lymphoma; Adult Diffuse Small Cleaved Cell Lymphoma; Adult Hodgkin Lymphoma; Adult Immunoblastic Large Cell Lymphoma; Adult Lymphoblastic Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Breast Cancer; Chronic Eosinophilic Leukemia; Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; Cutaneous T-cell Non-Hodgkin Lymphoma; Disseminated Neuroblastoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Grade 1 Follicular Lymphoma; Grade 2 Follicular Lymphoma; Grade 3 Follicular Lymphoma; Malignant Testicular Germ Cell Tumor; Mantle Cell Lymphoma; Marginal Zone Lymphoma; Multiple Myeloma; Mycosis Fungoides/Sezary Syndrome; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms; Neutropenia; Nodal Marginal Zone B-cell Lymphoma; Ovarian Epithelial Cancer; Ovarian Germ Cell Tumor; Plasma Cell Neoplasm; Poor Prognosis Metastatic Gestational Trophoblastic Tumor; Primary Myelofibrosis; Prolymphocytic Leukemia; Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma

  13. Safety and Tolerability Study of PCI-32765 in B Cell Lymphoma and Chronic Lymphocytic Leukemia

    Science.gov (United States)

    2017-10-09

    B-cell Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma; Diffuse Well-differentiated Lymphocytic Lymphoma; B Cell Lymphoma; Follicular Lymphoma; Mantle Cell Lymphoma; Non-Hodgkin's Lymphoma; Waldenstrom Macroglobulinemia; Burkitt Lymphoma; B-Cell Diffuse Lymphoma

  14. Danish National Lymphoma Registry

    DEFF Research Database (Denmark)

    Arboe, Bente; Josefsson, Pär; Jørgensen, Judit;

    2016-01-01

    AIM OF DATABASE: The Danish National Lymphoma Registry (LYFO) was established in order to monitor and improve the diagnostic evaluation and the quality of treatment of all lymphoma patients in Denmark. STUDY POPULATION: The LYFO database was established in 1982 as a seminational database including...... all lymphoma patients referred to the departments of hematology. The database became nationwide on January 1, 2000. MAIN VARIABLES: The main variables include both clinical and paraclinical variables as well as details of treatment and treatment evaluation. Up to four forms are completed for each...... patient: a primary registration form, a treatment form, a relapse form, and a follow-up form. Variables are used to calculate six result quality indicators (mortality 30 and 180 days after diagnosis, response to first-line treatment, and survival estimates 1, 3, and 5 years after the time of diagnosis...

  15. Antiviral Treatment of HCV-Infected Patients with B-Cell Non-Hodgkin Lymphoma: ANRS HC-13 Lympho-C Study

    Science.gov (United States)

    Alric, Laurent; Besson, Caroline; Lapidus, Nathanael; Jeannel, Juliette; Michot, Jean-Marie; Cacoub, Patrice; Canioni, Danielle; Pol, Stanislas; Davi, Frédéric; Rabiega, Pascaline; Ysebaert, Loic; Bonnet, Delphine; Hermine, Olivier

    2016-01-01

    Hepatitis C virus (HCV) infection is associated with lymphoproliferative disorders and B-cell non-Hodgkin lymphomas (B-NHLs). Evaluation of the efficacy and safety profiles of different antiviral therapies in HCV patients with B-NHL is warranted. Methods: First, we evaluated the sustained virologic response (SVR) and safety of Peg-interferon-alpha (Peg-IFN) + ribavirin +/- first protease inhibitors (PI1s) therapy in 61 HCV patients with B-NHL enrolled in a nationwide observational survey compared with 94 matched HCV-infected controls without B-NHL. In a second series, interferon-free regimens using a newly optimal combination therapy with direct-acting antiviral drugs (DAAs) were evaluated in 10 patients with HCV and B-NHL. Results: The main lymphoma type was diffuse large B-cell lymphoma (38%) followed by marginal zone lymphoma (31%). In the multivariate analysis, patients with B-NHL treated by Peg-IFN-based therapy exhibited a greater SVR rate compared with controls, 50.8% vs 30.8%, respectively, p<0.01, odds ratio (OR) = 11.2 [2.3, 52.8]. B-NHL response was better (p = 0.02) in patients with SVR (69%) than in patients without SVR (31%). Premature discontinuation of Peg-IFN-based therapy was significantly more frequent in the B-NHL group (19.6%) compared with the control group (6.3%), p<0.02. Overall, survival was significantly enhanced in the controls than in the B-NHL group (hazard ratio = 34.4 [3.9, 304.2], p< 0.01). Using DAAs, SVR was achieved in 9/10 patients (90%). DAAs were both well tolerated and markedly efficient. Conclusions: The virologic response of HCV-associated B-NHL is high. Our study provides a comprehensive evaluation of different strategies for the antiviral treatment of B-NHL associated with HCV infection. PMID:27749916

  16. Lymphoma of the Cervix

    Directory of Open Access Journals (Sweden)

    Juanita Parnis

    2012-01-01

    Full Text Available Primary non-Hodgkins lymphoma of the uterine cervix is a very rare diagnosis. A 54-year-old woman presented with a 3-month history of postmenopausal bleeding per vaginum. On examination, a friable, fungating lesion was seen on the cervix. Histology revealed a CD 20 positive high-grade non-Hodgkin’s diffuse large B cell lymphoma from cervical biopsies and endometrial curettage. She was diagnosed as stage IE after workup and subsequently treated with six cycles of R-CHOP chemotherapy followed by radiotherapy of the involved field.

  17. Primary Pancreatic Lymphomas

    Directory of Open Access Journals (Sweden)

    Muhammad Wasif Saif

    2006-05-01

    Full Text Available Extranodal non-Hodgkin’s lymphomas (NHLs represent up to 30-40% of all NHL cases. The gastrointestinal tract is the most commonly involved extranodal site; accounting for about half of such cases [1]. Stomach and the small intestine constitute the most common gastrointestinal sites. Secondary invasion of the pancreas from contiguous, retroperitoneal lymph node disease is the prevalent mode of involvement. Secondary involvement of the pancreas from the duodenum or adjacent peripancreatic lymphadenopathy is well-known. Primary pancreatic lymphoma (PPL is an extremely rare disease [2]. PPL can present as an isolated mass mimicking pancreatic carcinoma. However, unlike carcinomas, PPL are potentially treatable [3].

  18. A biodiversidade bentônica em lagoa marginal ao rio Paranapanema na zona de sua desembocadura, na represa de Jurumirim - DOI: 10.4025/actascibiolsci.v28i4.166 The benthic biodiversity in a lake marginal to the Paranapanema river in its mouth zone into Jurumirim reservoir- DOI: 10.4025/actascibiolsci.166

    Directory of Open Access Journals (Sweden)

    Rosemary Cristina Souza Davanso

    2007-11-01

    Full Text Available O presente trabalho teve como objetivo principal verificar a biodiversidade bentônica em áreas do fundo da lagoa do Coqueiral, zona de desembocadura do rio Paranapanema, na represa de Jurumirim, Estado de São Paulo. Foram selecionados dezoito pontos de amostragem, englobando áreas rasas e áreas profundas. As coletas foram feitas em intervalos trimestrais ao longo de um ano; também foram analisadas as variáveis físicas e químicas da água (nível, transparência, temperatura, oxigênio dissolvido, pH e condutividade elétrica. Amostras do sedimento, para análise da fauna e de fatores abióticos (granulometria e conteúdo orgânico, foram recolhidas em tréplicas, utilizando como coletor a draga de Petersen. O material foi triado e analisado sob microscópio estereoscópico. Contagem e identificação dos organismos foram realizadas, e densidade, abundância relativa, riqueza taxonômica e índice de dominância foram calculados. A análise revelou uma fauna com baixa diversidade e a dominância de Chironomidae e Ephemeroptera. Domínio de Ephemeroptera, constituído por Campsurus, ocorreu no período mais quente do ano e com baixa profundidade da lagoa. A distribuição dos organismos teve como principais fatores determinantes profundidade, transparência, pH e temperatura da água. Na comparação feita entre áreas rasas e profundas, foi observada uma menor densidade de organismos nas regiões profundas.Coqueiral lake is a marginal lake located at the southeast São Paulo State, in the mouth zone of the Paranapanema river into Jurumirim Reservoir and it has high connectivity with the Paranapanema river. This work aimed to verify the benthic biodiversity in areas of the lake bottom. 18 sampling sites in the lake were selected, including shallow and deep areas. The samples were taken every three months during one year. Physical and chemical water variables (level, transparency, dissolved oxygen, pH, and electric conductivity were

  19. Does Delayed-Time-Point Imaging Improve 18F-FDG-PET in Patients With MALT Lymphoma?

    Science.gov (United States)

    Mayerhoefer, Marius E.; Giraudo, Chiara; Senn, Daniela; Hartenbach, Markus; Weber, Michael; Rausch, Ivo; Kiesewetter, Barbara; Herold, Christian J.; Hacker, Marcus; Pones, Matthias; Simonitsch-Klupp, Ingrid; Müllauer, Leonhard; Dolak, Werner; Lukas, Julius; Raderer, Markus

    2016-01-01

    Purpose To determine whether in patients with extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue lymphoma (MALT), delayed–time-point 2-18F-fluoro-2-deoxy-d-glucose-positron emission tomography (18F-FDG-PET) performs better than standard–time-point 18F-FDG-PET. Materials and Methods Patients with untreated histologically verified MALT lymphoma, who were undergoing pretherapeutic 18F-FDG-PET/computed tomography (CT) and consecutive 18F-FDG-PET/magnetic resonance imaging (MRI), using a single 18F-FDG injection, in the course of a larger-scale prospective trial, were included. Region-based sensitivity and specificity, and patient-based sensitivity of the respective 18F-FDG-PET scans at time points 1 (45–60 minutes after tracer injection, TP1) and 2 (100–150 minutes after tracer injection, TP2), relative to the reference standard, were calculated. Lesion-to-liver and lesion-to-blood SUVmax (maximum standardized uptake values) ratios were also assessed. Results 18F-FDG-PET at TP1 was true positive in 15 o f 23 involved regions, and 18F-FDG-PET at TP2 was true-positive in 20 of 23 involved regions; no false-positive regions were noted. Accordingly, region-based sensitivities and specificities were 65.2% (confidence interval [CI], 45.73%–84.67%) and 100% (CI, 100%-100%) for 18F-FDG-PET at TP1; and 87.0% (CI, 73.26%–100%) and 100% (CI, 100%-100%) for 18F-FDG-PET at TP2, respectively. FDG-PET at TP1 detected lymphoma in at least one nodal or extranodal region in 7 of 13 patients, and 18F-FDG-PET at TP2 in 10 of 13 patients; accordingly, patient-based sensitivity was 53.8% (CI, 26.7%–80.9%) for 18F-FDG-PET at TP1, and 76.9% (CI, 54.0%–99.8%) for 18F-FDG-PET at TP2. Lesion-to-liver and lesion-to-blood maximum standardized uptake value ratios were significantly lower at TP1 (ratios, 1.05 ± 0.40 and 1.52 ± 0.62) than at TP2 (ratios, 1.67 ± 0.74 and 2.56 ± 1.10; P = 0.003 and P = 0.001). Conclusions Delayed–time-point imaging

  20. 毛乌素沙地、腾格里沙漠南缘带土地利用与气候变化关系研究——以宁夏中部为例%Relationship Between Land Use and the Climate Change in the Southern Marginal Zones of the Tengger Desert and Mu Us Desert —A Case Study in Central of Ningxia

    Institute of Scientific and Technical Information of China (English)

    贾科利; 张俊华; 郭占军

    2011-01-01

    利用1978年MSS及1987,1996和2007年Landsat TM/ETM遥感影像,借助GIS技术,对腾格里沙漠与毛乌素沙地南缘地带土地利用与气候变化的响应关系进行了研究.结果表明,研究区年均温升高,降水量减少,气候趋于暖干化,土地利用开发程度差异显著,表现出30 a来,毛乌素沙地南缘土地利用开发强度整体较大,高于腾格里沙漠南缘地带,在变化速度上,毛乌素沙地高于腾格里沙漠南缘地区.%By using the MSS image in 1978 and Landsat TM/ETM images in 1987, 1996, 2007 with the help of GIS, the relationship between land use and the climate change in the southern marginal zones of Tengger desert and Mu Us desert in central of Ningxia from 1978 to 2007 were analyzed. The results showed that under the conditions that the climate in north China trends to warming and drying, especially,under the control of the water and heat conditions, the degree of land use difference was significant in the southern marginal zones of Tengger desert and Mu Us desert. The land use level in the studying area was generally increased in the nearly past 30 years. But the land use level in the southern marginal zones of Mu Us desert was higher than that in the southern marginal zones of Tengger desert, as well as the speed of land use change in the southern marginal zones of Mu Us desert.

  1. Routine follow-up intervals in patients with high-grade squamous intraepithelial lesions (HSIL) and free excision margins can safely be increased in the first two years after Large Loop Excision of the Transformation Zone (LLETZ)

    NARCIS (Netherlands)

    Eijsink, J. J. H.; de Bock, G. H.; Kuiper, J. L.; Reesink-Peters, N.; van Hemel, B. M.; Hollema, H.; Nijman, H. W.; Mourits, M. J. E.; van der Zee, A. G. J.

    2009-01-01

    Objective. To assess the compliance of HSIL patients to the national Dutch routine follow-up protocol in the first 2 years after LLETZ and to determine if based on the status of excision margins, follow-up intervals could be modified. Methods. A prospective cohort study was performed in patients, re

  2. Routine follow-up intervals in patients with high-grade squamous intraepithelial lesions (HSIL) and free excision margins can safely be increased in the first two years after Large Loop Excision of the Transformation Zone (LLETZ)

    NARCIS (Netherlands)

    Eijsink, J. J. H.; de Bock, G. H.; Kuiper, J. L.; Reesink-Peters, N.; van Hemel, B. M.; Hollema, H.; Nijman, H. W.; Mourits, M. J. E.; van der Zee, A. G. J.

    2009-01-01

    Objective. To assess the compliance of HSIL patients to the national Dutch routine follow-up protocol in the first 2 years after LLETZ and to determine if based on the status of excision margins, follow-up intervals could be modified. Methods. A prospective cohort study was performed in patients, re

  3. Primary Pulmonary Hodgkin Lymphoma

    OpenAIRE

    Shumaila Tanveer; Ahmed El Damati; Ayman El Baz; Ahmed Alsayyah; Tarek ElSharkawy; Mohamed Regal

    2015-01-01

    Primary pulmonary Hodgkin lymphoma (PPHL) is a rare disease. Herein, we report a case of PPHL with diagnostic concerns encountered during initial evaluation which is of paramount importance to keep the differential diagnosis in cases with high index of sus- picion for this rare entity.

  4. Lymphoma: Immune Evasion Strategies

    Energy Technology Data Exchange (ETDEWEB)

    Upadhyay, Ranjan; Hammerich, Linda; Peng, Paul [Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029 (United States); Brown, Brian [Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029 (United States); Merad, Miriam [Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029 (United States); Brody, Joshua D., E-mail: joshua.brody@mssm.edu [Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029 (United States)

    2015-04-30

    While the cellular origin of lymphoma is often characterized by chromosomal translocations and other genetic aberrations, its growth and development into a malignant neoplasm is highly dependent upon its ability to escape natural host defenses. Neoplastic cells interact with a variety of non-malignant cells in the tumor milieu to create an immunosuppressive microenvironment. The resulting functional impairment and dysregulation of tumor-associated immune cells not only allows for passive growth of the malignancy but may even provide active growth signals upon which the tumor subsequently becomes dependent. In the past decade, the success of immune checkpoint blockade and adoptive cell transfer for relapsed or refractory lymphomas has validated immunotherapy as a possible treatment cornerstone. Here, we review the mechanisms by which lymphomas have been found to evade and even reprogram the immune system, including alterations in surface molecules, recruitment of immunosuppressive subpopulations, and secretion of anti-inflammatory factors. A fundamental understanding of the immune evasion strategies utilized by lymphomas may lead to better prognostic markers and guide the development of targeted interventions that are both safer and more effective than current standards of care.

  5. Lymphatic system and lymphoma

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    2009236 Clinical significance in detection of immunoglobulin heavy chain clonal rearrangement in bone marrow of patients with B cell lymphoma.CHEN Zhiyu(陈治宇),et al.Dept Med Oncol,Cancer Hosp,Fudan Univ;Dept Oncel,Shanghai Med Coll,Fudan Univ,Shanghai 200032,Chin J Oncol,2009;3193):183-188.

  6. Lymphatic system and lymphoma

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    970385 The changes of cell immune function in ap-tients with non-Hodgkin’s lymphoma by flow cytome-try analysis. LU Ming(吕鸣), et al. Clin ImmunolCenter, Changzheng Hosp, 2nd Milit Med Univ, Shang-hai, 200003. Shanghai Med J 1997; 20(2): 73-75.

  7. Centrofacial angiocentric lymphoma.

    Science.gov (United States)

    Peral-Cagigal, Beatriz; Galdeano-Arenas, María; Crespo-Pinilla, Juan Ignacio; García-Cantera, José Miguel; Sánchez-Cuéllar, Luis Antonio; Verrier-Hernández, Alberto

    2005-01-01

    The centrofacial angiocentric lymphoma is a rare lymphoid neoplasm, with an often-difficult diagnosis due to the non-specific clinical picture. On many occasions it is necessary to perform various biopsies to reach the correct diagnosis. This lymphoma is an aggressive Non-Hodgkin's (NHL) type, which is normally found in the upper respiratory tract (predominantly in the nasal cavity), and has an ominous prognosis, as the average survival rate is between 12 and 18 months (1). It is predominantly found in subjects of oriental and South American extraction, who are between the ages of 50 and 60 years and with a slight tendency towards males (2:1). This is the case study of a female Ecuadorian patient who was referred to our department with a hemifacial edema, chocolate- like rhinorrhea and nasal respiratory obstruction, which had been treated with antibiotics and anti-inflammatories for a month without success. After performing a number of diagnostic tests, it was found histologically that the patient had an extranodal T-cell lymphoma of the nasal type (also known as T-cell angiocentric lymphoma).

  8. Four Lymphomas in 1 Patient: A Unique Case of Triple Composite Non-Hodgkin Lymphoma Followed by Classical Hodgkin Lymphoma.

    Science.gov (United States)

    Tennese, Alysa; Skrabek, Pamela J; Nasr, Michel R; Sekiguchi, Debora R; Morales, Carmen; Brown, Theresa C; Weisenburger, Dennis D; Perry, Anamarija M

    2017-05-01

    Composite lymphomas consist of 2 or more distinct lymphomas occurring in a single anatomical site or simultaneously in different sites and can be composed of any combination of B-cell non-Hodgkin lymphoma (NHL), T-cell NHL, or Hodgkin lymphoma (HL). Cases of composite lymphomas with more than 2 lymphomas are extremely rare, with only 4 reports in the literature. We report the case of a 49-year-old man with a triple composite lymphoma in a single lymph node, consisting of small lymphocytic lymphoma, follicular lymphoma, and mantle cell lymphoma in situ. The patient received multiple courses of chemotherapy and an autologous stem cell transplant, which resulted in complete remission. Then, 6 years after the stem cell transplant, he developed classical HL. This unique case is, to our knowledge, the first report of a patient with triple composite lymphoma consisting of 3 small mature B-cell NHLs, who subsequently developed a fourth lymphoma.

  9. Hepatitis C: crioglobulinemia y linfoma no-Hodgkin Hepatitis C: cryoglobulinemia and non-Hodgkin lymphoma

    Directory of Open Access Journals (Sweden)

    M. Romero-Gómez

    2008-03-01

    some cases, cryoglobulinemia could appear after sustained response. Several steps in the pathogenesis of mixed cryoglobulinemia are strongly related to HCV infection and when the virus is eliminated, the disease course improves. However, independent steps related to other factors do not improve following viral clearance. In some types of low-grade non-Hodgkin lymphoma (lymphomoplasmocytic lymphoma, marginal zone lymphoma sustained response following antiviral treatment induces remission of the neoplasm. HCV has a minor role in aggressive lymphomas and clearance of the virus may not induce remission, but could decrease the hepatotoxicity associated with the chemotherapy. Therefore, in chronic hepatitis C, the combination of peginterferon + ribavirin is strongly recommended in treating symptomatic mixed cryoglobulinemia and HCV-related non-Hodgkin lymphomas.

  10. Assessment of Biomass Resources from Marginal Lands in APEC Economies

    Energy Technology Data Exchange (ETDEWEB)

    Milbrandt, A.; Overend, R. P.

    2009-08-01

    The goal of this study is to examine the marginal lands in Asia-Pacific Economic Cooperation (APEC) economies and evaluate their biomass productivity potential. Twelve categories of marginal lands are identified using the Global Agro-Ecological Zones system of the United Nations Food and Agriculture Organization.

  11. Treatment Options for Childhood Hodgkin Lymphoma

    Science.gov (United States)

    ... Hodgkin lymphoma. Lymphocyte-depleted Hodgkin lymphoma. Epstein-Barr virus infection increases the risk of childhood Hodgkin lymphoma. ... about health care. Reviewers and Updates Editorial Boards write the PDQ cancer information summaries and keep them ...

  12. General Information about Primary CNS Lymphoma

    Science.gov (United States)

    ... Research Primary CNS Lymphoma Treatment (PDQ®)–Patient Version General Information About Primary CNS Lymphoma Go to Health ... start in the eye (called ocular lymphoma). Enlarge Anatomy of the lymph system, showing the lymph vessels ...

  13. Marginalization of the Youth

    DEFF Research Database (Denmark)

    Jensen, Niels Rosendal

    2009-01-01

    The article is based on a key note speach in Bielefeld on the subject "welfare state and marginalized youth", focusing upon the high ambition of expanding schooling in Denmark from 9 to 12 years. The unintended effect may be a new kind of marginalization.......The article is based on a key note speach in Bielefeld on the subject "welfare state and marginalized youth", focusing upon the high ambition of expanding schooling in Denmark from 9 to 12 years. The unintended effect may be a new kind of marginalization....

  14. Multimodality imaging of cardiothoracic lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Carter, Brett W., E-mail: bcarter2@mdanderson.org [The University of Texas MD Anderson Cancer Center, Department of Diagnostic Radiology, Section of Thoracic Imaging, 1515 Holcombe Blvd., Unit 1478, Houston, TX 77030 (United States); Wu, Carol C. [Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, FND-202, Boston, MA 02114 (United States); Khorashadi, Leila [Department of Radiology, Mount Auburn Hospital, Cambridge, MA 02138 (United States); Godoy, Myrna C.B.; Groot, Patricia M. de [The University of Texas MD Anderson Cancer Center, Department of Diagnostic Radiology, Section of Thoracic Imaging, 1515 Holcombe Blvd., Unit 1478, Houston, TX 77030 (United States); Abbott, Gerald F. [Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, FND-202, Boston, MA 02114 (United States); Lichtenberger III, John P. [Department of Radiology, David Grant Medical Center, Travis AFB, CA 94535 (United States)

    2014-08-15

    Lymphoma is the most common hematologic malignancy and represents approximately 5.3% of all cancers. The World Health Organization published a revised classification scheme in 2008 that groups lymphomas by cell type and molecular, cytogenetic, and phenotypic characteristics. Most lymphomas affect the thorax at some stage during the course of the disease. Affected structures within the chest may include the lungs, mediastinum, pleura, and chest wall, and lymphomas may originate from these sites as primary malignancies or secondarily involve these structures after arising from other intrathoracic or extrathoracic sources. Pulmonary lymphomas are classified into one of four types: primary pulmonary lymphoma, secondary pulmonary lymphoma, acquired immunodeficiency syndrome-related lymphoma, and post-transplantation lymphoproliferative disorders. Although pulmonary lymphomas may produce a myriad of diverse findings within the lungs, specific individual features or combinations of features can be used, in combination with secondary manifestations of the disease such as involvement of the mediastinum, pleura, and chest wall, to narrow the differential diagnosis. While findings of thoracic lymphoma may be evident on chest radiography, computed tomography has traditionally been the imaging modality used to evaluate the disease and effectively demonstrates the extent of intrathoracic involvement and the presence and extent of extrathoracic spread. However, additional modalities such as magnetic resonance imaging of the thorax and {sup 18}F-FDG PET/CT have emerged in recent years and are complementary to CT in the evaluation of patients with lymphoma. Thoracic MRI is useful in assessing vascular, cardiac, and chest wall involvement, and PET/CT is more accurate in the overall staging of lymphoma than CT and can be used to evaluate treatment response.

  15. Hypothermia & Hodgkin lymphoma in children

    OpenAIRE

    Köse, Doğan; Köksal, Yavuz; Çalışkan, Ümran

    2016-01-01

    Hypothermia associated with Hodgkin lymphoma is defined rarely. This may be caused by a dysfunction that shall occur in hypothalamus, central and peripheral vascular system, skin and muscles. In this study, two Hodgkin lymphoma cases with developed hypothermia are presented. Case 1: An “Hodgkin lymphoma, mixed cellular type” was diagnosed by a biopsy conducted due to lesions found in her spleen on a girl in 7 ages, who applied to the hospital with complaints such as fever, weight loss and nig...

  16. Current Issues in Histology, Biology and Prognosis of Hodgkin Lymphoma

    Directory of Open Access Journals (Sweden)

    Marjanović Goran

    2017-06-01

    Full Text Available High risk Hodgkin lymphoma patients may occasionally have borderline characteristics similar to gray zone lymphomas and T-cell/histiocyte rich B cell lymphomas. These entities require different and more aggressive treatment modalities. Aggressive behavior is often associated with disturbances caused by Epstein Barr virus, or immune evasion caused by overexpression of check point inhibitors PDL-1 and PDL-2 coupled with the lack of expression of Class I and II MHC molecules. Galectin-1, TARC, sCD163 and other surrogate markers of immunosuppression in Hodgkin lymphoma may be useful for the assessment of treatment response. The improvements in lymphoma management diminished the importance of prognostic factors unified in the International Prognostic Scoring system, reducing them from 7 to 3 factors that remained relevant. Interim PET analysis is the only method able to identify resistant patients while chemotherapy is ongoing, thus enabling adjustment of treatment according to the treatment response. Efforts for stratification of patients according to disease histology, biology, microenvironment, clinical scoring systems and PET scan are ongoing. Current breakthroughs have set strong background for novel therapies with monoclonal antibodies and check point inhibitors that will result in improvement of management of high risk patients.

  17. Prevalence of Golden retriever in European dogs with lymphoma: preliminary data

    Directory of Open Access Journals (Sweden)

    Marzia Cozzi

    2017-05-01

    Full Text Available Introduction. Canine breeds, being genetic clusters, are good models for studies on genetic predisposition. Golden retriever (GR has been described with a high incidence of both lymphoma overall (19% and T zone lymphoma (TZL, 40% with differences in different geographical areas in US. This breed predisposition is confirmed in Japanese but not in European (EU case series although specific studies are still lacking. Aim of the present study is to investigate the prevalence of GR in a huge case series of canine lymphomas from different EU countries and to compare prevalence of different subtypes with studies in extra-EU countries, in order to support a possible different genetic predisposition. Materials and methods. Signalment data on 1734 consecutive cases of canine lymphoma collected from 9 different European countries are retrospectively analysed. When subtypes are available, cases are furtherly separated in three subtype groups: 1 B-cell lymphoma, 2 T-cell lymphoma-high grade, 3 TZL. Odds ratio (OR for different lymphoma subtypes are calculated in comparison with mixed breed population, considered as control. Results. Overall prevalence of GR is 5.19% (range 1.59-7.32% of lymphoma cases and differs from that reported in American and Japanese caseloads. Prevalence slightly varies among EU countries and no subtypes predilection is found if compared with mixed breed. Concerning Italian cohort, GR is not predisposed to develop a lymphoma when normalized for the breed prevalence (OR=1.49, 95% confidence interval=0.87-2.55, p=0.14. Discussion. Prevalence of lymphoma in EU population of GR is much lower than that of US. No predisposition is identified in EU GR for TZL differently from US and Japan. Being genetic of European GR population quite different from American and Japanese ones this suggest a possible different genetic predisposition. Slight differences in GR lymphoma prevalence among European countries likely reflects different breed

  18. Lymphoma-associated dysimmune polyneuropathies.

    Science.gov (United States)

    Stübgen, Joerg-Patrick

    2015-08-15

    Lymphoma consists of a variety of malignancies of lymphocyte origin. A spectrum of clinical peripheral neuropathy syndromes with different disease mechanisms occurs in about 5% of lymphoma patients. There exists a complex inter-relationship between lymphoproliferative malignancies and autoimmunity. An imbalance in the regulation of the immune system presumably underlies various immune-mediated neuropathies in patients with lymphoma. This article reviews lymphoma and more-or-less well-defined dysimmune neuropathy subgroups that are caused by humoral and/or cell-mediated immune disease mechanisms directed against known or undetermined peripheral nerve antigens.

  19. Pathobiology of Hodgkin Lymphoma

    Directory of Open Access Journals (Sweden)

    Pier Paolo Piccaluga

    2011-01-01

    Full Text Available Despite its well-known histological and clinical features, Hodgkin's lymphoma (HL has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics, histogenesis, and possible mechanisms of lymphomagenesis. There is complete consensus on the B-cell derivation of the tumor in most cases, and on the relevance of Epstein-Barr virus infection and defective cytokinesis in at least a proportion of patients. The REAL/WHO classification recognizes a basic distinction between lymphocyte predominance HL (LP-HL and classic HL (cHL, reflecting the differences in clinical presentation and behavior, morphology, phenotype, and molecular features. cHL has been classified into four subtypes: lymphocyte rich, nodular sclerosing, with mixed cellularity, and lymphocyte depleted. The borders between cHL and anaplastic large-cell lymphoma have become sharper, whereas those between LP-HL and T-cell-rich B-cell lymphoma remain ill defined. Treatments adjusted to the pathobiological characteristics of the tumor in at-risk patients have been proposed and are on the way to being applied.

  20. Intravascular lymphoma mimicking vasculitis.

    Science.gov (United States)

    Prayson, Richard A

    2016-12-01

    Intravascular lymphoma is a rare malignancy which is characterized by a proliferation of atypical appearing B cells, generally confined to vascular lumina. A tissue biopsy demonstrating the pathology is required to make a diagnosis. The tumor is often disseminated at the time of diagnosis and prognosis is poor, even with aggressive chemotherapy. Neurologic presentations of this neoplasm can be quite varied. This report documents the presence of intravascular lymphoma diagnosed on a brain biopsy in a 60-year-old man. He initially presented 6months before brain biopsy with chest pain and hypotension, warranting coronary artery bypass graft surgery. Four months later, he presented with signs attributed to a stroke (diaphoresis, slumped over in a chair and left hand weakness). He subsequently developed a sudden onset wide-based gait, left leg numbness, word finding difficulties and worsening confusion. A MRI study showed multiple infarcts in the brain, including cerebellum. Invasive angiogram suggested vasculitis. He was started on a course of treatment for presumed central nervous system vasculitis. He continued to develop signs suggestive of ongoing infarct development and a biopsy from the right parietal was taken. The biopsy showed atypical intravascular CD20 positive staining B cells, consistent with intravascular lymphoma. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Interpretation of free-air gravity anomaly data for determining the crustal structure across the continental margins and aseismic ridges: Some examples from Indian continental margins and deep-sea basins

    Digital Repository Service at National Institute of Oceanography (India)

    Ramana, M.V.

    of Alaska and Japan trench, east of the Japanese Islands. Gravity anomalies across continental margins Continental margins are at or near to the transition zone between continental and oceanic crusts. Passive margins are commonly in isostatic.... Generalized bathymetry map of the Indian continental margins After Mishra et al., (2004) The western and eastern margins of India are classified under passive/Atlantic type continental margins, and the structural architecture is similar to any...

  2. Practical Marginalized Multilevel Models.

    Science.gov (United States)

    Griswold, Michael E; Swihart, Bruce J; Caffo, Brian S; Zeger, Scott L

    2013-01-01

    Clustered data analysis is characterized by the need to describe both systematic variation in a mean model and cluster-dependent random variation in an association model. Marginalized multilevel models embrace the robustness and interpretations of a marginal mean model, while retaining the likelihood inference capabilities and flexible dependence structures of a conditional association model. Although there has been increasing recognition of the attractiveness of marginalized multilevel models, there has been a gap in their practical application arising from a lack of readily available estimation procedures. We extend the marginalized multilevel model to allow for nonlinear functions in both the mean and association aspects. We then formulate marginal models through conditional specifications to facilitate estimation with mixed model computational solutions already in place. We illustrate the MMM and approximate MMM approaches on a cerebrovascular deficiency crossover trial using SAS and an epidemiological study on race and visual impairment using R. Datasets, SAS and R code are included as supplemental materials.

  3. Danish National Lymphoma Registry

    Directory of Open Access Journals (Sweden)

    Arboe B

    2016-10-01

    Full Text Available Bente Arboe,1 Pär Josefsson,2 Judit Jørgensen,3 Jacob Haaber,4 Paw Jensen,5 Christian Poulsen,6 Dorthe Rønnov-Jessen,7 Robert S Pedersen,8 Per Pedersen,9 Mikael Frederiksen,10 Michael Pedersen,1 Peter de Nully Brown1 1Department of Hematology, Copenhagen University Hospital, Rigshospitalet, 2Department of Hematology, Copenhagen University Hospital, Herlev Hospital, Copenhagen, 3Department of Hematology, Aarhus University Hospital, Aarhus, 4Department of Hematology, Odense University Hospital, Odense, 5Department of Hematology, Aalborg University Hospital, Aalborg, 6Department of Hematology, Roskilde Hospital, Roskilde, 7Department of Hematology, Vejle Hospital, Vejle, 8Department of Hematology, Holstebro Hospital, Holstebro, 9Department of Hematology, Esbjerg Hospital, Esbjerg, 10Department of Hematology, Haderslev Hospital, Haderslev, Denmark Aim of database: The Danish National Lymphoma Registry (LYFO was established in order to monitor and improve the diagnostic evaluation and the quality of treatment of all lymphoma patients in Denmark. Study population: The LYFO database was established in 1982 as a seminational database including all lymphoma patients referred to the departments of hematology. The database became nationwide on January 1, 2000. Main variables: The main variables include both clinical and paraclinical variables as well as details of treatment and treatment evaluation. Up to four forms are completed for each patient: a primary registration form, a treatment form, a relapse form, and a follow-up form. Variables are used to calculate six result quality indicators (mortality 30 and 180 days after diagnosis, response to first-line treatment, and survival estimates 1, 3, and 5 years after the time of diagnosis, and three process quality indicators (time from diagnosis until the start of treatment, the presence of relevant diagnostic markers, and inclusion rate in clinical protocols. Descriptive data: Approximately 23

  4. Tyrosine phosphorylation in human lymphomas

    NARCIS (Netherlands)

    Haralambieva, E; Jones, M.; Roncador, GM; Cerroni, L; Lamant, L; Ott, G; Rosenwald, A; Sherman, C; Thorner, P; Kusec, R; Wood, KM; Campo, E; Falini, B; Ramsay, A; Marafioti, T; Stein, H; Kluin, PM; Pulford, K; Mason, DY

    2002-01-01

    In a previous study, we showed that the high level of protein tyrosine phosphorylation present in lymphomas containing an anaplastic lymphoma kinase (ALK) can be demonstrated in routinely processed paraffin tissue sections using immunolabelling techniques. In the present study we investigated

  5. Lymphoma risk in systemic lupus

    DEFF Research Database (Denmark)

    Bernatsky, Sasha; Ramsey-Goldman, Rosalind; Joseph, Lawrence

    2014-01-01

    OBJECTIVE: To examine disease activity versus treatment as lymphoma risk factors in systemic lupus erythematosus (SLE). METHODS: We performed case-cohort analyses within a multisite SLE cohort. Cancers were ascertained by regional registry linkages. Adjusted HRs for lymphoma were generated...

  6. Lymphoma of the Urinary Bladder

    Directory of Open Access Journals (Sweden)

    Anthony Kodzo-Grey Venyo

    2014-01-01

    Full Text Available Background. Lymphoma of the urinary bladder (LUB is rare. Aims. To review the literature on LUB. Methods. Various internet databases were used. Results. LUB can be either primary or secondary. The tumour has female predominance; most cases occur in middle-age women. Secondary LUB occurs in 10% to 25% of leukemias/lymphomas and in advanced-stage systemic lymphoma. Less than 100 cases have been reported. MALT typically affects adults older than 60 years; 75% are female. Diffuse large B-cell lymphoma is also common and may arise from transformation of MALT. LUB presents with haematuria, dysuria, urinary frequency, nocturia, and abdominal or back pain. Macroscopic examination of LUBs show large discrete tumours centred in the dome or lateral walls of the bladder. Positive staining of LUB varies by the subtype of lymphoma; B-cell lymphomas are CD20 positive. MALT lymphoma is positively stained for CD20, CD19, and FMC7 and negatively stained for CD5, CD10, and CD11c. LUB stains negatively with Pan-keratin, vimentin, CK20, and CK7. MALT lymphoma exhibits t(11; 18(q21: 21. Radiotherapy is an effective treatment for the MALT type of LUB with no recurrence. Conclusions. LUB is diagnosed by its characteristic morphology and immunohistochemical characteristics. Radiotherapy is a useful treatment.

  7. 惰性淋巴瘤非化疗药物的治疗现状及进展%Advances and the current status in chemotherapy-free management for indolent lym-phomas

    Institute of Scientific and Technical Information of China (English)

    宋腾(综述); 王华庆(审校)

    2016-01-01

    Indolent B-cell lymphomas constitute a slow growing cancer of the lymphatic system. These lymphomas mainly include fol-licular lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, Waldenstom macroglobulinemia, marginal zone lym-phoma, and low malignant mantle cell lymphoma. These lymphomas are sensitive to chemotherapy and/or immunochemotherapy, but they cannot be cured. Furthermore, patient age at diagnosis, patient age at time of first onset or subsequent relapses, and compli-cations often influence the chemotherapy curative effect. At present, recent progress has been achieved in our understanding of dys-regulated pathways and immunologic anti-tumor responses in indolent lymphoma. In particular, the breakthrough of non-cytotoxic drugs renders"chemo-free"treatment a near-future reality. In this review, we highlight these promising approaches, such as the com-bination of anti-CD20 antibodies with immunomodulatory drugs, mAbs directed against other surface antigens, and programmed cell death 1 (PD-1) receptor inhibitor or B-cell receptor signaling pathway inhibitors. Future phase III studies will evaluate the efficacy of these drugs in the context of non-chemotherapy and further clarify treatment status.%惰性B细胞淋巴瘤是一类生长缓慢的淋巴系统肿瘤,主要包括滤泡性淋巴瘤(follicular lymphoma,FL)、慢性淋巴细胞白血病(chronic lymphocytic leukemia,CLL)/小淋巴细胞淋巴瘤(small lymphocytic lymphoma,SLL)、华氏巨球蛋白血症(waldenstom mac⁃roglobulinemia,WM)、边缘区淋巴瘤(marginal zone lymphoma,MZL)以及低度恶性的套细胞淋巴瘤(low malignant mantle cell lym⁃phoma,MCL)等,对化疗及免疫治疗敏感,但无法治愈。患者发病年龄、首次发病及再次复发时间、并发症等均可影响化疗疗效。当前,在惰性淋巴瘤信号转导通路及抗肿瘤免疫反应等方面,尤其是非细胞毒药物研究的突破,支持了

  8. Monoclonal Antibody Therapy Before Stem Cell Transplant in Treating Patients With Relapsed or Refractory Lymphoid Malignancies

    Science.gov (United States)

    2015-12-07

    Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

  9. DNA-methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control

    Science.gov (United States)

    Betts, Matthew J.; Carrillo-de-Santa-Pau, Enrique; Doose, Gero; Gutwein, Jana; Richter, Julia; Hovestadt, Volker; Huang, Bingding; Rico, Daniel; Jühling, Frank; Kolarova, Julia; Lu, Qianhao; Otto, Christian; Wagener, Rabea; Arnolds, Judith; Burkhardt, Birgit; Claviez, Alexander; Drexler, Hans G.; Eberth, Sonja; Eils, Roland; Flicek, Paul; Haas, Siegfried; Humme, Michael; Karsch, Dennis; Kerstens, Hinrik H.D.; Klapper, Wolfram; Kreuz, Markus; Lawerenz, Chris; Lenzek, Dido; Loeffler, Markus; López, Cristina; MacLeod, Roderick A.F.; Martens, Joost H.A.; Kulis, Marta; Martín-Subero, José Ignacio; Möller, Peter; Nage, Inga; Picelli, Simone; Vater, Inga; Rohde, Marius; Rosenstiel, Philip; Rosolowski, Maciej; Russell, Robert B.; Schilhabel, Markus; Schlesner, Matthias; Stadler, Peter F.; Szczepanowski, Monika; Trümper, Lorenz; Stunnenberg, Hendrik G.; Küppers, Ralf; Ammerpohl, Ole; Lichter, Peter; Siebert, Reiner; Hoffmann, Steve; Radlwimmer, Bernhard

    2017-01-01

    In spite of both having features of germinal center B-cells, Burkitt lymphomas and follicular lymphomas are biologically and clinically quite diverse. We here performed whole genome bisulfite, genome and transcriptome sequencing from 13 IG-MYC-translocation positive Burkitt lymphoma, 9 BCL2-translocation positive follicular lymphoma and four normal germinal center B-cell samples. Comparison of Burkitt and follicular lymphoma samples revealed differential methylation of intragenic regions that strongly correlated with expression of associated genes, e.g. genes active in germinal center dark zone and light zone B-cells. Integrative pathway analyses of regions differentially methylated between Burkitt and follicular lymphoma implicated DNA methylation to cooperate with somatic mutation of sphingosine-phosphate signaling, as well as the TCF3/ID3 and SWI/SNF complexes in a large fraction of Burkitt lymphomas. Taken together, our results demonstrate a tight connection between somatic mutation, DNA methylation and transcriptional control in key B-cell pathways deregulated differentially between Burkitt and other germinal center B-cell lymphomas. PMID:26437030

  10. [Malignant non-Hodgkin's lymphoma].

    Science.gov (United States)

    Bourrier, P; Grodner, F; Ruf, R; Texier, J; Cottencin, R; Cousteau, C; Deslandre, A; Gounant, C; Szpirglas, H; Laufer, J

    1983-01-01

    Rapid regression of all symptoms was obtained after moderate chemotherapy in two women aged 69 and 77 years respectively with malignant non-Hodgkin's lymphomas. Cervico-facial locations of these tumors are discussed in relation to definition, etiology, geographic factors, genetic markers, and associated immunologic disorders. Diagnosis requires a series of explorations including, obviously as a last resort, exploratory cervicotomy. Other regions may be involved and must be investigated, but lesions not affecting lymph nodes occur in only approximately 2 p. cent of patients with cervico-facial malignant non-Hodgkin's lymphoma (approximately 10 p. cent of all malignant non-Hodgkin's lymphomas). Other localizations include the hard palate, gums, sinuses, and salivary glands. Burkitt's lymphoma represents, on the contrary, 30 p. cent of malignant non-Hodgkin's lymphoma seen in European children. The different therapeutic modalities available are discussed.

  11. Ocean margins workshop

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-12-31

    The Department of Energy (DOE) is announcing the refocusing of its marine research program to emphasize the study of ocean margins and their role in modulating, controlling, and driving Global Change phenomena. This is a proposal to conduct a workshop that will establish priorities and an implementation plan for a new research initiative by the Department of Energy on the ocean margins. The workshop will be attended by about 70 scientists who specialize in ocean margin research. The workshop will be held in the Norfolk, Virginia area in late June 1990.

  12. "We call ourselves marginalized"

    DEFF Research Database (Denmark)

    Jørgensen, Nanna Jordt

    2014-01-01

    In recent decades, indigenous knowledge has been added to the environmental education agenda in an attempt to address the marginalization of non-western perspectives. While these efforts are necessary, the debate is often framed in terms of a discourse of victimization that overlooks the agency o...... argue that researchers not only need to pay attention to how certain voices are marginalized in Environmental Education research and practice, but also to how learners as agents respond to, use and negotiate the marginalization of their perspectives....

  13. Pretreatment T lymphocyte numbers are contributing to the prognostic significance of absolute lymphocyte numbers in B-cell non-Hodgkins lymphomas.

    Science.gov (United States)

    Gergely, Lajos; Váncsa, Andrea; Miltényi, Zsófia; Simon, Zsófia; Baráth, Sándor; Illés, Árpád

    2011-06-01

    Targeted immuno-chemotherapy resulted in greatly improved survival of B cell lymphoma patients. Several prognostic markers are investigated, amongst them the pretreatment absolute lymphocyte numbers. We investigated lymphocyte subpopulations and correlated this data with prognosis of patients. 88 patients (mean age: 56 years, 18-88, median follow up 32 months) with B cell lymphomas were investigated. There were 51 DLBCL, 16 Follicular NHL, 4 MALT, 7 Marginal Zone NHL, 10 Small lymphocytic cases were investigated. Our data showed that overall survival was statistically significant up to the 0.9 G/l absolute lymphocyte numbers as dividers between the subgroups. The CD19+ B cell numbers, or the CD56+/CD3- NK cell numbers did not represent any significant differences between subgroups. However CD3+, CD4+ and CD8+ T cells were differentiating statistically significant subgroups. Pretreatment CD3+ cell number less than 700/ul and CD8+ cell number less than 200/ul were corresponding with significantly inferior overall survival. These could be verified in the bad prognostic IPI group as well. Our data further support the importance of pretreatment lymphocyte numbers and highlight CD3+ and CD8+ lymphocytes to be the key factors in predicting outcome.

  14. Iodine I 131 Monoclonal Antibody BC8 Before Autologous Stem Cell Transplant in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma

    Science.gov (United States)

    2016-06-10

    Recurrent B-Cell Non-Hodgkin Lymphoma; Recurrent Hodgkin Lymphoma; Recurrent T-Cell Non-Hodgkin Lymphoma; Refractory B-Cell Non-Hodgkin Lymphoma; Refractory Hodgkin Lymphoma; Refractory T-Cell Non-Hodgkin Lymphoma

  15. Gastric Lymphoma with Secondary Trigeminal Nerve Lymphoma: A Case Report

    Directory of Open Access Journals (Sweden)

    Warissara Rongthong

    2017-05-01

    Full Text Available Data supporting the role of radiotherapy in secondary trigeminal nerve lymphoma is scarce. Here, I report the case of 64-year-old Thai male diagnosed as gastric diffuse large B cell lymphoma with secondary trigeminal nerve lymphoma. He had previously received one cycle of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP, followed by five cycles of rituximab plus CHOP (R-CHOP with intrathecal methotrexate (MTX and cytarabine (Ara-C. One month after the last cycle of R-CHOP, he developed a headache and numbness on the left side of his face. MRI revealed thickening of the left trigeminal nerve. He received one intrathecal injection of MTX and Ara-C, followed by systemic chemotherapy. After receiving intrathecal chemotherapy, his symptoms disappeared. Clinical response and MRI studies suggested secondary trigeminal nerve lymphoma. Two months later, our patient’s secondary trigeminal nerve lymphoma had progressed. Salvage whole brain irradiation (36 Gy with boost dose (50 Gy along the left trigeminal nerve was given. Unfortunately, our patient developed heart failure and expired during the radiotherapy session. In conclusion and specific to secondary central nervous system lymphoma (SCNSL, radiotherapy may benefit patients who fail to respond to systemic chemotherapy and palliative treatment. The results this report fail to support the role of radiotherapy in secondary trigeminal nerve lymphoma.

  16. Indian Ocean margins

    Digital Repository Service at National Institute of Oceanography (India)

    Naqvi, S.W.A.

    The most important biogeochemical transformations and boundary exchanges in the Indian Ocean seem to occur in the northern region, where the processes originating at the land-ocean boundary extend far beyond the continental margins. Exchanges across...

  17. Learning unbelievable marginal probabilities

    CERN Document Server

    Pitkow, Xaq; Miller, Ken D

    2011-01-01

    Loopy belief propagation performs approximate inference on graphical models with loops. One might hope to compensate for the approximation by adjusting model parameters. Learning algorithms for this purpose have been explored previously, and the claim has been made that every set of locally consistent marginals can arise from belief propagation run on a graphical model. On the contrary, here we show that many probability distributions have marginals that cannot be reached by belief propagation using any set of model parameters or any learning algorithm. We call such marginals `unbelievable.' This problem occurs whenever the Hessian of the Bethe free energy is not positive-definite at the target marginals. All learning algorithms for belief propagation necessarily fail in these cases, producing beliefs or sets of beliefs that may even be worse than the pre-learning approximation. We then show that averaging inaccurate beliefs, each obtained from belief propagation using model parameters perturbed about some le...

  18. Lymphatic system and lymphoma

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930583 Analysis of therapeutic efficacy of com- bination chemotherapy and adjuvant radiothera-py in 207 cases of diffuse non—Hodgkin’s lym-phoma.YONG Weiben(勇威本),et al.BeijingCancer Res Instit,Beijing,100000. Chin J Hema-tol 1992;13(12):638—640.Two hundred and seven cases of diffuse non—Hodgkin’s lymphoma(D—NHL)were treatedwith combination chemotherapy(cyclophospha-mide,vincristine,procarbazine,prednisone andpingyingmycin or adriamycin)and adjuvant ra-diotherapy.Complete remission(CR)wasachieved in 94 of 207 patients(45.4%),partial

  19. Ethnic variation in medical and lifestyle risk factors for B cell non-Hodgkin lymphoma: A case-control study among Israelis and Palestinians

    Science.gov (United States)

    Perlman, Riki; Khatib, Areej; Abdeen, Ziad; Elyan, Husein; Nirel, Ronit; Amir, Gail; Ramlawi, Asad; Sabatin, Fouad; Boffetta, Paolo; Dann, Eldad J.; Kedmi, Meirav; Ellis, Martin; Nagler, Arnon; Ben Yehuda, Dina; Paltiel, Ora

    2017-01-01

    Background Risk factors for B-cell non-Hodgkin lymphoma (B-NHL) have not been assessed among Palestinian Arabs (PA) and Israeli Jews (IJ). Methods In a case-control study we investigated self-reported medical and lifestyle exposures, reporting odds ratios (ORs) and 95% confidence intervals [CIs], by ethnicity, for overall B-NHL and subtypes. Results We recruited 823 cases and 808 healthy controls. Among 307 PA/516 IJ B-NHL cases (mean age at diagnosis = 51 [±17] versus 60 [±15] years, respectively) subtype distributions differed, with diffuse large B-cell lymphoma (DLBCL) being prominent among PA (71%) compared to IJ (41%); follicular lymphoma (FL), was observed in 14% versus 28%, and marginal zone lymphoma, in 2% versus 14%, respectively. Overall B-NHL in both populations was associated with recreational sun exposure OR = 1.43 [CI:1.07–1.91], black hair-dye use OR = 1.70 [CI:1.00–2.87], hospitalization for infection OR = 1.68 [CI:1.34–2.11], and first-degree relative with hematopoietic cancer, OR = 1.69 [CI:1.16–2.48]. An inverse association was noted with alcohol use, OR = 0.46 [CI:0.34–0.62]. Subtype-specific exposures included smoking (FL, OR = 1.46 [CI:1.01–2.11]) and >monthly indoor pesticide use (DLBCL, OR = 2.01 [CI:1.35–3.00]). Associations observed for overall B-NHL in PA only included: gardening OR = 1.93 [CI:1.39–2.70]; history of herpes, mononucleosis, rubella, blood transfusion (OR>2.5, P<0.01 for all); while for IJ risk factors included growing fruits and vegetables, OR = 1.87 [CI:1.11–3.15]; and self-reported autoimmune diseases, OR = 1.99 [CI:1.34–2.95]. Conclusions In these geographically proximate populations we found some unique risk factors for B-NHL. Heterogeneity in the observed associations by ethnicity could reflect differences in lifestyle, medical systems, and reporting patterns, while variations by histology infer specific etiologic factors for lymphoma subtypes. PMID:28196110

  20. Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant

    Science.gov (United States)

    2016-12-15

    HIV Infection; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Plasmablastic Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Non-Hodgkin Lymphoma; Recurrent Burkitt Lymphoma; Recurrent Follicular Lymphoma; Stage III Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage IV Follicular Lymphoma; Stage IV Mantle Cell Lymphoma

  1. How I treat double-hit lymphoma.

    Science.gov (United States)

    Friedberg, Jonathan W

    2017-08-03

    The 2016 revision of the World Health Organization (WHO) classification for lymphoma has included a new category of lymphoma, separate from diffuse large B-cell lymphoma, termed high-grade B-cell lymphoma with translocations involving myc and bcl-2 or bcl-6. These lymphomas, which occur in <10% of cases of diffuse large B-cell lymphoma, have been referred to as double-hit lymphomas (or triple-hit lymphomas if all 3 rearrangements are present). It is important to differentiate these lymphomas from the larger group of double-expressor lymphomas, which have increased expression of MYC and BCL-2 and/or BCL-6 by immunohistochemistry, by using variable cutoff percentages to define positivity. Patients with double-hit lymphomas have a poor prognosis when treated with standard chemoimmunotherapy and have increased risk of central nervous system involvement and progression. Double-hit lymphomas may arise as a consequence of the transformation of the underlying indolent lymphoma. There are no published prospective trials in double-hit lymphoma, however retrospective studies strongly suggest that aggressive induction regimens may confer a superior outcome. In this article, I review my approach to the evaluation and treatment of double-hit lymphoma, with an eye toward future clinical trials incorporating rational targeted agents into the therapeutic armamentarium. © 2017 by The American Society of Hematology.

  2. Homing of human B cells to lymphoid organs and B-cell lymphoma engraftment are controlled by cell adhesion molecule JAM-C.

    Science.gov (United States)

    Doñate, Carmen; Ody, Christiane; McKee, Thomas; Ruault-Jungblut, Sylvie; Fischer, Nicolas; Ropraz, Patricia; Imhof, Beat A; Matthes, Thomas

    2013-01-15

    Junctional adhesion molecule C (JAM-C) is expressed by vascular endothelium and human but not mouse B lymphocytes. The level of JAM-C expression defines B-cell differentiation stages and allows the classification of marginal zone-derived (JAM-C-positive) and germinal center-derived (JAM-C-negative) B-cell lymphomas. In the present study, we investigated the role of JAM-C in homing of human B cells, using a xenogeneic nonobese diabetic/severe combined immunodeficient mouse model. Treatment with anti-JAM-C antibodies in short-term experiments reduced migration of normal and malignant JAM-C-expressing B cells to bone marrow, lymph nodes, and spleen. Blocking homing to the spleen is remarkable, as most other antiadhesion antibodies reduce homing of B cells only to bone marrow and lymph nodes. Long-term administration of anti-JAM-C antibodies prevented engraftment of JAM-Cpos lymphoma cells in bone marrow, spleen, and lymph nodes of mice. Plasmon resonance studies identified JAM-B as the major ligand for JAM-C, whereas homotypic JAM-C interactions remained at background levels. Accordingly, anti-JAM-C antibodies blocked adhesion of JAM-C-expressing B cells to their ligand JAM-B, and immunofluorescence analysis showed the expression of JAM-B on murine and human lymphatic endothelial cells. Targeting JAM-C could thus constitute a new therapeutic strategy to prevent lymphoma cells from reaching supportive microenvironments not only in the bone marrow and lymph nodes but also in the spleen.

  3. Biclonal low grade B-cell lymphoma confirmed by both flow cytometry and karyotypic analysis, in spite of a normal kappa/lambda Ig light chain ratio.

    Science.gov (United States)

    Delville, J P; Heimann, P; El Housni, H; Boutriaux, M; Jeronnez, A; Remmelink, M; Lasudry, J; Pradier, O; Kentos, A

    2007-06-01

    Composite low grade lymphoma with two subpopulations in a same site is uncommon. We herewith report the case of an 80-year-old woman who presented with isolated bilateral dacryoadenomegaly. Pathological examination of an incisional biopsy of her right lacrimal gland was consistent with a marginal zone lymphoma. Flow cytometry immunophenotyping showed two distinct clonal B-cell populations expressing sIg D lambda or sIg M kappa restriction in the lacrimal gland, blood, and bone marrow. Both B-cells populations were sorted from peripheral blood for molecular biology investigations and comparison with molecular data performed on tumor and bone marrow cells. IgH PCR performed on purified blood populations disclosed two monoclonal peaks: 98 bp-sized peak in the sIg M kappa and a 107 bp in the sIg D lambda clones, respectively. The lacrimal gland tumor expressed mainly sIg M kappa population, and showed a major 98 bp-sized peak coexisting with a very minor 107 bp peak. Cytogenetic studies showed a 46, XX,del (7) (q22q32) karyotype. Bone marrow examination at diagnosis revealed the same B-cell clones distribution than the one observed in blood with a dominant sIg D lambda population, a Genescan profile showing a major peak of 107 bp and a minor peak of 98 bp. Chromosomal analysis disclosed a 46,XX,del (10) (?p14) karyotype without detectable 7q deletion. To our knowledge, this observation represents the first reported case of biclonal low grade lymphoma hidden behind a normal classical kappa/lambda Ig light chain ratio in blood, but clearly demonstrated by the combination of three ancillary techniques (flow cytometry both analytical and cell sorting, molecular biology, and cytogenetics) and analysis of different tissues (i.e., in this case, lacrimal gland biopsy, blood, and bone marrow).

  4. From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma

    Directory of Open Access Journals (Sweden)

    Mégraud Francis

    2010-06-01

    Full Text Available Abstract Background elicobacter pylori infection is associated with several gastro-duodenal inflammatory diseases of various levels of severity. To determine whether certain combinations of genetic markers can be used to predict the clinical source of the infection, we analyzed well documented and geographically homogenous clinical isolates using a comparative genomics approach. Results A set of 254 H. pylori genes was used to perform array-based comparative genomic hybridization among 120 French H. pylori strains associated with chronic gastritis (n = 33, duodenal ulcers (n = 27, intestinal metaplasia (n = 17 or gastric extra-nodal marginal zone B-cell MALT lymphoma (n = 43. Hierarchical cluster analyses of the DNA hybridization values allowed us to identify a homogeneous subpopulation of strains that clustered exclusively with cagPAI minus MALT lymphoma isolates. The genome sequence of B38, a representative of this MALT lymphoma strain-cluster, was completed, fully annotated, and compared with the six previously released H. pylori genomes (i.e. J99, 26695, HPAG1, P12, G27 and Shi470. B38 has the smallest H. pylori genome described thus far (1,576,758 base pairs containing 1,528 CDSs; it contains the vacAs2m2 allele and lacks the genes encoding the major virulence factors (absence of cagPAI, babB, babC, sabB, and homB. Comparative genomics led to the identification of very few sequences that are unique to the B38 strain (9 intact CDSs and 7 pseudogenes. Pair-wise genomic synteny comparisons between B38 and the 6 H. pylori sequenced genomes revealed an almost complete co-linearity, never seen before between the genomes of strain Shi470 (a Peruvian isolate and B38. Conclusion These isolates are deprived of the main H. pylori virulence factors characterized previously, but are nonetheless associated with gastric neoplasia.

  5. Lymphoma caused by intestinal microbiota.

    Science.gov (United States)

    Yamamoto, Mitsuko L; Schiestl, Robert H

    2014-09-01

    The intestinal microbiota and gut immune system must constantly communicate to maintain a balance between tolerance and activation: on the one hand, our immune system should protect us from pathogenic microbes and on the other hand, most of the millions of microbes in and on our body are innocuous symbionts and some can even be beneficial. Since there is such a close interaction between the immune system and the intestinal microbiota, it is not surprising that some lymphomas such as mucosal-associated lymphoid tissue (MALT) lymphoma have been shown to be caused by the presence of certain bacteria. Animal models played an important role in establishing causation and mechanism of bacteria-induced MALT lymphoma. In this review we discuss different ways that animal models have been applied to establish a link between the gut microbiota and lymphoma and how animal models have helped to elucidate mechanisms of microbiota-induced lymphoma. While there are not a plethora of studies demonstrating a connection between microbiota and lymphoma development, we believe that animal models are a system which can be exploited in the future to enhance our understanding of causation and improve prognosis and treatment of lymphoma.

  6. PATHOBIOLOGY OF HODGKIN LYMPHOMA

    Directory of Open Access Journals (Sweden)

    Claudio Agostinelli

    2014-06-01

    Full Text Available Hodgkin’s lymphoma is a lymphoid tumour that represents about 1% of all de novo neoplasms occurring every year worldwide. Its diagnosis is based on the identification of characteristic neoplastic cells within an inflammatory milieu. Molecular studies have shown that most, if not all cases, belong to the same clonal population, which is derived from peripheral B-cells. The relevance of Epstein-Barr virus infection at least in a proportion of patients was also demonstrated. The REAL/WHO classification recognizes a basic distinction between nodular lymphocyte predominance  HL (NLPHL and classic HL (CHL, reflecting the differences in clinical presentation, behavior, morphology, phenotype, molecular features as well as in the composition of their cellular background. CHL has been classified into four subtypes: lymphocyte rich, nodular sclerosing, mixed cellularity and lymphocyte depleted. Despite its well known histological and clinical features, Hodgkin's lymphoma (HL has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics and possible mechanisms of lymphomagenesis.

  7. Haemorrhage and intestinal lymphoma

    Directory of Open Access Journals (Sweden)

    Attilia M. Pizzini

    2013-04-01

    Full Text Available Background: The prevalence of coeliac disease is around 1% in general population but this is often unrecognised. The classical presentation of adult coeliac disease is characterized by diarrhoea and malabsorption syndrome, but atypical presentations are probably more common and are characterized by iron deficiency anaemia, weight loss, fatigue, infertility, arthralgia, peripheral neuropathy and osteoporosis. Unusual are the coagulation disorders (prevalence 20% and these are due to vitamin K malabsorption (prolonged prothrombin time. Clinical case: A 64-year-old man was admitted to our Department for an extensive spontaneous haematoma of the right leg. He had a history of a small bowel resection for T-cell lymphoma, with a negative follow-up and he didn’t report any personal or familiar history of bleeding. Laboratory tests showed markedly prolonged prothrombin (PT and partial-thromboplastin time (PTT, corrected by mixing studies, and whereas platelet count and liver tests was normal. A single dose (10 mg of intravenous vitamin K normalized the PT. Several days before the patient had been exposed to a superwarfarin pesticide, but diagnostic tests for brodifacoum, bromadiolone or difenacoum were negative. Diagnosis of multiple vitamin K-dependent coagulationfactor deficiencies (II, VII, IX, X due to intestinal malabsorption was made and coeliac disease was detected. Therefore the previous lymphoma diagnosis might be closely related to coeliac disease. Conclusions: A gluten free diet improves quality of life and restores normal nutritional and biochemical status and protects against these complications.

  8. Rituximab In Indolent Lymphomas

    Science.gov (United States)

    Sousou, Tarek; Friedberg, Jonathan

    2010-01-01

    Indolent Non Hodgkin's lymphoma (NHL) comprises a group of incurable, generally slow growing lymphomas highly responsive to initial therapy with a relapsing and progressive course. Rituximab, an anti CD-20 antibody, has had a large impact on treatment of indolent NHL. Its effectiveness as a single agent and in conjunction with known chemotherapy regimens has made it a standard of care in the treatment of NHL. Analysis of data obtained from NHL clinical trials as well as data from the National Cancer Institute indicates that the overall survival of indolent NHL has improved since the discovery of rituximab. Given its effectiveness and tolerability, it is currently being investigated as a maintenance agent with encouraging results. This review summarizes several landmark trials utilizing rituximab as a single agent and in combination with chemotherapy for treatment of NHL. In addition, a review of the studied rituximab maintenance dosing schedules and its impact on NHL will also be presented. Overall, rituximab has changed the landscape for treatment of indolent NHL however additional research is necessary to identify the optimal dosing schedule as well as patients most likely to respond to prolonged rituximab therapy. PMID:20350660

  9. Obinutuzumab in follicular lymphoma.

    Science.gov (United States)

    Martinez-Calle, N; Figueroa-Mora, R; Villar-Fernandez, S; Marcos-Jubilar, M; Panizo, C

    2016-12-01

    The CD20 marker continues to be exploited as a therapeutic target for non-Hodgkin's lymphoma. Obinutuzumab is part of a new generation of anti-CD20 monoclonal antibodies, which are synthesized using molecular engineering technology, resulting in novel target epitopes and unprecedented optimization of antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis. Rituximab is the current gold standard for anti-CD20 therapy, yet despite outstanding results published over the past decade, many patients continue to relapse after anti-CD20 regimens. Obinutuzumab is slowly positioning itself in the treatment of CD20+ B-cell neoplasms. On the basis of favorable results from the phase III GADOLIN trial, obinutuzumab was recently approved by the U.S. Food and Drug Administration in combination with bendamustine followed by obinutuzumab maintenance, for the treatment of follicular lymphoma (FL) patients who relapsed or are refractory to a rituximab-containing regimen. Additional phase III trials are underway to test obinutuzumab as a first-line anti-CD20 agent in FL with good preliminary results (GALLIUM trial); thus, it is likely that obinutuzumab will soon achieve a first-line indication. It is plausible that obinutuzumab will replace rituximab as the gold standard for chemoimmunotherapy in FL, although some safety concerns still need to be resolved. This review will address the preclinical pharmacology and the main aspects of the clinical development of obinutuzumab for the treatment of FL.

  10. Hodgkin Lymphoma: Diagnosis and Treatment.

    Science.gov (United States)

    Ansell, Stephen M

    2015-11-01

    Hodgkin lymphoma is a rare B-cell malignant neoplasm affecting approximately 9000 new patients annually. This disease represents approximately 11% of all lymphomas seen in the United States and comprises 2 discrete disease entities--classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma. Within the subcategorization of classical Hodgkin lymphoma are defined subgroups: nodular sclerosis, mixed cellularity, lymphocyte depletion, and lymphocyte-rich Hodgkin lymphoma. Staging of this disease is essential for the choice of optimal therapy. Prognostic models to identify patients at high or low risk for recurrence have been developed, and these models, along with positron emission tomography, are used to provide optimal therapy. The initial treatment for patients with Hodgkin lymphoma is based on the histologic characteristics of the disease, the stage at presentation, and the presence or absence of prognostic factors associated with poor outcome. Patients with early-stage Hodgkin lymphoma commonly receive combined-modality therapies that include abbreviated courses of chemotherapy followed by involved-field radiation treatment. In contrast, patients with advanced-stage Hodgkin lymphoma commonly receive a more prolonged course of combination chemotherapy, with radiation therapy used only in selected cases. For patients with relapse or refractory disease, salvage chemotherapy followed by high-dose treatment and an autologous stem cell transplant is the standard of care. For patients who are ineligible for this therapy or those in whom high-dose therapy and autologous stem cell transplant have failed, treatment with brentuximab vedotin is a standard approach. Additional options include palliative chemotherapy, immune checkpoint inhibitors, nonmyeloablative allogeneic stem cell transplant, or participation in a clinical trial testing novel agents.

  11. A rare case of breast carcinoma co-existing with axillary mantle cell lymphoma

    Directory of Open Access Journals (Sweden)

    Scally John

    2003-12-01

    Full Text Available Abstract Background Mantle cell lymphoma (MCL is a rare variety of non-Hodgkin's lymphoma which originates from CD5+ B-cell population in the mantle zones of lymphoid follicles. Coexistence of such tumours in the axillary lymph nodes with invasive breast cancers without prior history of adjuvant chemotherapy or radiotherapy has not been previously reported in literature. Case report We report a rare case of breast cancer co-existing with stage I mantle cell lymphoma of the ipsilateral axillary lymph node detected fortuitously by population screening. Conclusion Though some studies have tried to prove breast carcinomas and lymphomas to share a common molecular or viral link, more research needs to be done to establish whether such a link truly exists.

  12. General Information about Childhood Non-Hodgkin Lymphoma

    Science.gov (United States)

    ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ... Treatment Adult NHL Treatment AIDS-Related Lymphoma Treatment Mycosis Fungoides & Sézary Syndrome Treatment Primary CNS Lymphoma Treatment ...

  13. Proton therapy for Hodgkin lymphoma.

    Science.gov (United States)

    Rutenberg, Michael S; Flampouri, Stella; Hoppe, Bradford S

    2014-09-01

    Hodgkin lymphoma has gone from an incurable disease to one for which the majority of patients will be cured. Combined chemotherapy and radiotherapy achieves the best disease control rates and results in many long-term survivors. As a result, a majority of long-term Hodgkin lymphoma survivors live to experience severe late treatment-related complications, especially cardiovascular disease and second malignancies. The focus of research and treatment for Hodgkin lymphoma is to maintain the current high rates of disease control while reducing treatment-related morbidity and mortality. Efforts to reduce late treatment complications focus on improvements in both systemic therapies and radiotherapy. Herein we review the basis for the benefits of proton therapy over conventional X-ray therapy. We review outcomes of Hodgkin lymphoma treated with proton therapy, and discuss the ability of protons to reduce radiation dose to organs at risk and the impact on the most significant late complications related to the treatment.

  14. Intracranial manifestations of malignant lymphomas

    Energy Technology Data Exchange (ETDEWEB)

    Galanski, M.; Fahrendorf, G.; Urbanitz, D.; Beckmann, A.; Elger, C.

    1985-06-01

    Approximately 10% of patients with malignant lymphoma will show neurological symptoms at some time during the course of their illness. In non-Hodgkin lymphoma, CNS involvement is more frequent than in Hodgkin's disease. Diffuse histiocytic and poorly differentiated lymphomas, bone marrow involvement, advanced tumor stage and hematogenous spread are particular risk factors. Invasion of the spinal canal is the most common type of CNS involvement. Intracranial lesions, which are comparatively rare, may present as intracerebral metastases, epi- or subdural masses or focal or diffuse leptomeningeal disease. Lymphomatous leptomeningitis usually cannot be demonstrated by CT. On the other hand, dural and cerebral parenchymal lesions are sometimes highly characteristic of lymphoma as a result of their features and location.

  15. Primary intracerebral lymphoma: Case report

    Directory of Open Access Journals (Sweden)

    Olcay Eser

    2012-09-01

    Full Text Available We describe a case of primary central nervous lymphoma (PCNSL that may be confused with magnetic resonance imaging (MRI findings of high grade glioma. Primary central nervous lymphoma is a rare tumour and it account for 0.3-3% of intracranial tumours. A 61 year’s old woman was admitted to our clinic with a severe headache, vomiting, left hemiparesia and transient loss of consciousness. Primary central nervous lymphoma may show various biological and radiological characteristics. We herein emphasized being confused with MRI findings of PCNSL and high grade glioma. J Clin Exp Invest 2012; 3 (3: 409-411Key words: Primary central nervous lymphoma, high grade glioma, B-cell, diagnosis

  16. Targeted immunotherapy in Hodgkin lymphoma

    DEFF Research Database (Denmark)

    Hutchings, Martin

    2015-01-01

    In this issue of Blood, Rothe et al introduce a new principle of targeted Hodgkin lymphoma (HL) immunotherapy in their report from a phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13.......In this issue of Blood, Rothe et al introduce a new principle of targeted Hodgkin lymphoma (HL) immunotherapy in their report from a phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13....

  17. A Phase II Trial of Panobinostat and Lenalidomide in Patients With Relapsed or Refractory Hodgkin's Lymphoma

    Science.gov (United States)

    2017-01-24

    Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma

  18. Gemcitabine and Bendamustine in Patients With Relapsed or Refractory Hodgkin's Lymphoma

    Science.gov (United States)

    2017-07-10

    Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma

  19. Anti-CD22 CAR-T Therapy for CD19-refractory or Resistant Lymphoma Patients

    Science.gov (United States)

    2016-08-22

    Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Stage III/IV Adult Diffuse Large Cell Lymphoma; Stage III/IV Follicular Lymphoma; Stage III/IV Mantle Cell Lymphoma

  20. Primary lymphoma of the colon

    Directory of Open Access Journals (Sweden)

    Tauro Leo

    2009-01-01

    Full Text Available Primary lymphoma of the colon is a rare tumor of the gastrointestinal (GI tract and comprises only 0.2-1.2% of all colonic malignancies. The most common variety of colonic lymphoma is non-Hodgkin′s lymphoma (NHL. The GI tract is the most frequently involved site, accounting for 30-40% of all extra nodal lymphomas, approximately 4-20% of which are NHL. The stomach is the most common location of GI lymphomas, followed by the small intestine. Early diagnosis may prevent intestinal perforation; however, the diagnosis is often delayed in most cases. Therapeutic approaches described in two subsets include: Radical tumor resection (hemicolectomy plus multi-agent chemotherapy (polychemotherapy in early stage patients, biopsy plus multidrug chemotherapy in advanced stage patients. Radiotherapy is reserved for specific cases; surgery alone can be considered as an adequate treatment for patients with low-grade NHL disease that does not infiltrate beyond the sub mucosa. Although resection plays an important role in the local control of the disease and in preventing bleeding and/or perforation, it rarely eradicates the lymphoma by itself. Those with limited stage disease may enjoy prolonged survival when treated with aggressive chemotherapy.

  1. Cenozoic deformation and evolution of the Niushou Shan-Luo Shan fault zone in the northeast margin of the Tibet Plateau%青藏高原东北缘牛首山—罗山断裂带新生代构造变形与演化

    Institute of Scientific and Technical Information of China (English)

    陈虹; 胡健民; 公王斌; 李利波

    2013-01-01

    The Niushou Shan-Luo Shan fault zone is located in the outer edge of the northeastern Tibet Plateau and separates the northeast margin of the Tibet Plateau from the Ordos block.The structural features of the main faults and regional tectonic analysis indicate that the Niushou Shan-Luo Shan fault zone may have undergone four stages of paleo-stress field in the Cenozoic.Combined with the geochronological information,the Cenozoic tectonic evolution may be constrained as follows:N-S compression and thrust in the Late Eocene-Oligocene,NW-SE compression and sinistral strike-slip in the Late Miocene to the Pliocene,NNE-SSW compression and dextral strike-slip in the Late Pliocene to the Middle Pleistocene,and E-W compression and extension since the Late Pleistocene.The intensive structural deformation of the fault zone commenced at the Late Miocene,implying that the margin of the Northeastern Tibet Plateau had extended to the Niushou Shan-Luo Shan fault zone at the time.Our study indicates that the Cenozoic tectonic evolution of the Niushou Shan-Luo Shan fault zone was closely related to the Indian-Eurasian continental collision and the Tibet Plateau uplifting,recording the northeastward growth of the Tibet Plateau and the Cenozoic tectonic transition of the Ordos block.%牛首山—罗山断裂带分隔了青藏高原东北缘和鄂尔多斯地块两大构造单元,是青藏高原东北缘最外缘的一条断裂带.通过断裂带内详细的构造变形测量,结合区域构造分析与筛分,获得新生代4期构造应力场.通过年代学的初步研究,提出牛首山—罗山断裂带新生代构造演化序列,即:始新世末渐新世近N-S向挤压逆冲变形、中新世晚期—上新世NW-SE向挤压与左行走滑活动、上新世末 中更新世NNE-SSW向挤压与右行走滑活动、晚更新世以来近E-W向挤压与伸展构造.其中强烈的构造变形起始于中新世晚期,表明青藏高原东北缘的边界扩展在中新世晚期已经到达

  2. Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer

    Science.gov (United States)

    2016-06-13

    Acute Undifferentiated Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Childhood Burkitt Lymphoma; Childhood Chronic Myelogenous Leukemia; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Childhood Myelodysplastic Syndromes; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Chronic Myelomonocytic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Juvenile Myelomonocytic Leukemia; Mast Cell Leukemia; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T

  3. Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer

    Science.gov (United States)

    2016-08-01

    Acute Undifferentiated Leukemia; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Childhood Burkitt Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Grade III Lymphomatoid Granulomatosis; Childhood Immunoblastic Large Cell Lymphoma; Childhood Myelodysplastic Syndromes; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Chronic Myelomonocytic Leukemia; Cutaneous B-cell Non-Hodgkin Lymphoma; de Novo Myelodysplastic Syndromes; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Juvenile Myelomonocytic Leukemia; Mast Cell Leukemia; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Myeloid/NK-cell Acute Leukemia; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Previously Treated Myelodysplastic Syndromes; Primary Systemic Amyloidosis; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma