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Sample records for lymphoma enterprise architecture

  1. Development of the Lymphoma Enterprise Architecture Database: A caBIG(TM Silver Level Compliant System

    Directory of Open Access Journals (Sweden)

    Taoying Huang

    2009-01-01

    Full Text Available Lymphomas are the fifth most common cancer in United States with numerous histological subtypes. Integrating existing clinical information on lymphoma patients provides a platform for understanding biological variability in presentation and treatment response and aids development of novel therapies. We developed a cancer Biomedical Informatics Grid™ (caBIG™ Silver level compliant lymphoma database, called the Lymphoma Enterprise Architecture Data-system™ (LEAD™, which integrates the pathology, pharmacy, laboratory, cancer registry, clinical trials, and clinical data from institutional databases. We utilized the Cancer Common Ontological Representation Environment Software Development Kit (caCORE SDK provided by National Cancer Institute’s Center for Bioinformatics to establish the LEAD™ platform for data management. The caCORE SDK generated system utilizes an n-tier architecture with open Application Programming Interfaces, controlled vocabularies, and registered metadata to achieve semantic integration across multiple cancer databases. We demonstrated that the data elements and structures within LEAD™ could be used to manage clinical research data from phase 1 clinical trials, cohort studies, and registry data from the Surveillance Epidemiology and End Results database. This work provides a clear example of how semantic technologies from caBIG™ can be applied to support a wide range of clinical and research tasks, and integrate data from disparate systems into a single architecture. This illustrates the central importance of caBIG™ to the management of clinical and biological data.

  2. Development of the Lymphoma Enterprise Architecture Database: A caBIG(TM Silver Level Compliant System

    Directory of Open Access Journals (Sweden)

    Taoying Huang

    2009-04-01

    Full Text Available Lymphomas are the fifth most common cancer in United States with numerous histological subtypes. Integrating existing clinical information on lymphoma patients provides a platform for understanding biological variability in presentation and treatment response and aids development of novel therapies. We developed a cancer Biomedical Informatics Grid™ (caBIG™ Silver level compliant lymphoma database, called the Lymphoma Enterprise Architecture Data-system™ (LEAD™, which integrates the pathology, pharmacy, laboratory, cancer registry, clinical trials, and clinical data from institutional databases. We utilized the Cancer Common Ontological Representation Environment Software Development Kit (caCORE SDK provided by National Cancer Institute’s Center for Bioinformatics to establish the LEAD™ platform for data management. The caCORE SDK generated system utilizes an n-tier architecture with open Application Programming Interfaces, controlled vocabularies, and registered metadata to achieve semantic integration across multiple cancer databases. We demonstrated that the data elements and structures within LEAD™ could be used to manage clinical research data from phase 1 clinical trials, cohort studies, and registry data from the Surveillance Epidemiology and End Results database. This work provides a clear example of how semantic technologies from caBIG™ can be applied to support a wide range of clinical and research tasks, and integrate data from disparate systems into a single architecture. This illustrates the central importance of caBIG™ to the management of clinical and biological data.

  3. Development of the Lymphoma Enterprise Architecture Database: A caBIG(tm) Silver level compliant System

    Science.gov (United States)

    Huang, Taoying; Shenoy, Pareen J.; Sinha, Rajni; Graiser, Michael; Bumpers, Kevin W.; Flowers, Christopher R.

    2009-01-01

    Lymphomas are the fifth most common cancer in United States with numerous histological subtypes. Integrating existing clinical information on lymphoma patients provides a platform for understanding biological variability in presentation and treatment response and aids development of novel therapies. We developed a cancer Biomedical Informatics Grid™ (caBIG™) Silver level compliant lymphoma database, called the Lymphoma Enterprise Architecture Data-system™ (LEAD™), which integrates the pathology, pharmacy, laboratory, cancer registry, clinical trials, and clinical data from institutional databases. We utilized the Cancer Common Ontological Representation Environment Software Development Kit (caCORE SDK) provided by National Cancer Institute’s Center for Bioinformatics to establish the LEAD™ platform for data management. The caCORE SDK generated system utilizes an n-tier architecture with open Application Programming Interfaces, controlled vocabularies, and registered metadata to achieve semantic integration across multiple cancer databases. We demonstrated that the data elements and structures within LEAD™ could be used to manage clinical research data from phase 1 clinical trials, cohort studies, and registry data from the Surveillance Epidemiology and End Results database. This work provides a clear example of how semantic technologies from caBIG™ can be applied to support a wide range of clinical and research tasks, and integrate data from disparate systems into a single architecture. This illustrates the central importance of caBIG™ to the management of clinical and biological data. PMID:19492074

  4. Development of the Lymphoma Enterprise Architecture Database: a caBIG Silver level compliant system.

    Science.gov (United States)

    Huang, Taoying; Shenoy, Pareen J; Sinha, Rajni; Graiser, Michael; Bumpers, Kevin W; Flowers, Christopher R

    2009-04-03

    Lymphomas are the fifth most common cancer in United States with numerous histological subtypes. Integrating existing clinical information on lymphoma patients provides a platform for understanding biological variability in presentation and treatment response and aids development of novel therapies. We developed a cancer Biomedical Informatics Grid (caBIG) Silver level compliant lymphoma database, called the Lymphoma Enterprise Architecture Data-system (LEAD), which integrates the pathology, pharmacy, laboratory, cancer registry, clinical trials, and clinical data from institutional databases. We utilized the Cancer Common Ontological Representation Environment Software Development Kit (caCORE SDK) provided by National Cancer Institute's Center for Bioinformatics to establish the LEAD platform for data management. The caCORE SDK generated system utilizes an n-tier architecture with open Application Programming Interfaces, controlled vocabularies, and registered metadata to achieve semantic integration across multiple cancer databases. We demonstrated that the data elements and structures within LEAD could be used to manage clinical research data from phase 1 clinical trials, cohort studies, and registry data from the Surveillance Epidemiology and End Results database. This work provides a clear example of how semantic technologies from caBIG can be applied to support a wide range of clinical and research tasks, and integrate data from disparate systems into a single architecture. This illustrates the central importance of caBIG to the management of clinical and biological data.

  5. Enterprise Architecture beyond the Enterprise

    DEFF Research Database (Denmark)

    Tambo, Torben

    2017-01-01

    of this discipline is the topic of this paper. This paper is taking a point of departure in general theories of business-to-business relationships along with inter-organisational information systems, interoperability and business ecosystems. The general theories are applied to the Extended Enterprise Architecture...... organisational boundaries. A case is presented of an enterprise engaging in technology-based business process integration that in turn is explicated as enterprise architecture initiatives with both more and less powerful partners. This paper underlines the necessity to be able to have EA spanning initiatives......As the most enterprises are relying on relations to other enterprises, it is relevant to consider enterprise architecture for inter-organisational relations particularly those relations involving technology. This has been conceptualised as Extended Enterprise Architecture, and a systematic review...

  6. Lightweight enterprise architectures

    CERN Document Server

    Theuerkorn, Fenix

    2004-01-01

    STATE OF ARCHITECTUREArchitectural ChaosRelation of Technology and Architecture The Many Faces of Architecture The Scope of Enterprise Architecture The Need for Enterprise ArchitectureThe History of Architecture The Current Environment Standardization Barriers The Need for Lightweight Architecture in the EnterpriseThe Cost of TechnologyThe Benefits of Enterprise Architecture The Domains of Architecture The Gap between Business and ITWhere Does LEA Fit? LEA's FrameworkFrameworks, Methodologies, and Approaches The Framework of LEATypes of Methodologies Types of ApproachesActual System Environmen

  7. Enterprise architecture management

    DEFF Research Database (Denmark)

    Rahimi, Fatemeh; Gøtze, John; Møller, Charles

    2017-01-01

    Despite the growing interest in enterprise architecture management, researchers and practitioners lack a shared understanding of its applications in organizations. Building on findings from a literature review and eight case studies, we develop a taxonomy that categorizes applications of enterprise...... architecture management based on three classes of enterprise architecture scope. Organizations may adopt enterprise architecture management to help form, plan, and implement IT strategies; help plan and implement business strategies; or to further complement the business strategy-formation process....... The findings challenge the traditional IT-centric view of enterprise architecture management application and suggest enterprise architecture management as an approach that could support the consistent design and evolution of an organization as a whole....

  8. Enterprise architecture management

    DEFF Research Database (Denmark)

    Rahimi, Fatemeh; Gøtze, John; Møller, Charles

    2017-01-01

    architecture management based on three classes of enterprise architecture scope. Organizations may adopt enterprise architecture management to help form, plan, and implement IT strategies; help plan and implement business strategies; or to further complement the business strategy-formation process......Despite the growing interest in enterprise architecture management, researchers and practitioners lack a shared understanding of its applications in organizations. Building on findings from a literature review and eight case studies, we develop a taxonomy that categorizes applications of enterprise....... The findings challenge the traditional IT-centric view of enterprise architecture management application and suggest enterprise architecture management as an approach that could support the consistent design and evolution of an organization as a whole....

  9. Enterprise Architecture beyond the Enterprise:Extended Enterprise Architecture Revisited

    OpenAIRE

    Tambo, Torben

    2017-01-01

    As the most enterprises are relying on relations to other enterprises, it is relevant to consider enterprise architecture for inter-organisational relations particularly those relations involving technology. This has been conceptualised as Extended Enterprise Architecture, and a systematic review of this discipline is the topic of this paper. This paper is taking a point of departure in general theories of business-to-business relationships along with inter-organisational information systems,...

  10. Enterprise architecture intelligence

    NARCIS (Netherlands)

    Veneberg, R.K.M.; Iacob, Maria Eugenia; van Sinderen, Marten J.; Bodenstaff, L.; Reichert, M.U.; Rinderle-Ma, S.; Grossmann, G.

    2014-01-01

    Combining enterprise architecture and operational data is complex (especially when considering the actual ‘matching’ of data with enterprise architecture objects), and little has been written on how to do this. Therefore, in this paper we aim to fill this gap and propose a method to combine

  11. Enterprise architecture for business success

    CERN Document Server

    Wijegunaratne, Inji; Evans-Greenwood, Peter

    2014-01-01

    Enterprise Architecture (EA) has evolved to become a prominent presence in today's information systems and technology landscape. The EA discipline is rich in frameworks, methodologies, and the like. However, the question of 'value' for business ;professionals remains largely unanswered - that is, how best can Enterprise Architecture and Enterprise Architects deliver value to the enterprise? Enterprise Architecture for Business Success answers this question. Enterprise Architecture for Business Success is primarily intended for IT professionals working in the area of Enterprise Architectu

  12. Enterprise Architecture Evaluation

    DEFF Research Database (Denmark)

    Andersen, Peter; Carugati, Andrea

    2014-01-01

    By being holistically preoccupied with coherency among organizational elements such as organizational strategy, business needs and the IT functions role in supporting the business, enterprise architecture (EA) has grown to become a core competitive advantage. Though EA is a maturing research area...

  13. Incorporating enterprise strategic plans into enterprise architecture

    NARCIS (Netherlands)

    Lins Borges Azevedo, Carlos

    2017-01-01

    In the last years, information technology (IT) executives have identified IT-business strategic alignment as a top management concern. In the information technology area, emphasis has been given to the Enterprise Architecture (EA) discipline with respect to enterprise management. The focus of the

  14. Evaluation of Enterprise Architecture Interoperability

    National Research Council Canada - National Science Library

    Jamison, Theresa A; Niska, Brice T; Layman, Phillip A; Whitney, Steven P

    2005-01-01

    ...), which describes these architectures. The purpose of this project, suggested by Air Force Space Command, was to examine the value of existing analytical tools in making an interoperability assessment of individual enterprises, as well...

  15. Enterprise Architecture (EA) Roadmap

    Data.gov (United States)

    Office of Personnel Management — The Enterprise Roadmap reflects the information technology (IT) investment priorities established in agency PortfolioStat reviews, as well as IT program decisions...

  16. Project Compliance with Enterprise Architecture

    NARCIS (Netherlands)

    Foorthuis, R.M.

    2012-01-01

    This research project set out to identify effective practices and models for working with projects that are required to comply with Enterprise Architecture (EA), and investigate the benefits and drawbacks brought about by compliance. Research methods used are canonical action research, a statistical

  17. Sourcing from an Enterprise Architecture Perspective

    DEFF Research Database (Denmark)

    Gøtze, John; Axél, Mette

    2013-01-01

    Enterprise architecture offers direct input in order to define the appropriate combination of people, components and services used to produce and deliver products and services. Sourcing, as the process of optimally organizing and procuring this inside and outside an organization, is therefore...... a central enterprise architecture concern. In this chapter we will discuss how enterprise architecture can benefit an enterprise’s sourcing strategy....

  18. An architectural framework for virtual enterprise engineering

    DEFF Research Database (Denmark)

    Zwegers, Arian; Hannus, Matti; Tølle, Martin

    2001-01-01

    , especially concerning integration issues. This paper aims to lay down an architectural framework to support the set-up and operation of virtual enterprises. It supports virtual enterprise engineering. The framework might also be used to identify and position issues that play a role in the set......-up and operation of virtual enterprises. As such, it is useful to classify research projects on virtual enterprises as well.......Enterprises cooperate more extensively with other enterprises during the entire product life cycle. Temporary alliances between various enterprises emerge such as those in virtual enterprises. However, many enterprises experience difficulties in the formation and operation of virtual enterprises...

  19. VERA: Virtual Enterprise Reference Architecture

    DEFF Research Database (Denmark)

    Vesterager, Johan; Tølle, Martin; Bernus, Peter

    2003-01-01

    . To prepare for this is a complex task, in fact all business, management and planning views, and related subject areas and activities, may be involved. In order to deal with this complexity in a systematic way and secure global understanding Globemen has developed a Virtual Enterprise Reference Architecture......Globalisation, outsourcing and customisation are main challenges of today not least for one-of-a-kind producers. A crucial competitive factor will be the ability rapidly to form customer focused virtual enterprises comprised of competencies from different partners by taking full advantage of ICT...

  20. VA Enterprise Design Patters - 2.5 (Enterprise Architecture)

    Data.gov (United States)

    Department of Veterans Affairs — Enterprise architectural guidelines and constraints that provide references to the use of enterprise capabilities that will enable the VA to access and exchange data...

  1. ORGANIZATIONAL CAPITAL IN ENTERPRISE ARCHITECTURE

    Directory of Open Access Journals (Sweden)

    Kirill G. Skripkin

    2016-01-01

    Full Text Available The paper describes a new approach to the description of organizational capital in enterprise architecture. This approach is focused on internal consistency of organizational mechanisms and their fit to the requirements of technologies in use and key employees. The description rests on Henry Mintzberg organizational design theory. The value of this description is demonstrated for the case of influence of Ministry of Education and Science policy on the organizational capital of the Russian university.

  2. How does Enterprise Architecture support innovation?

    DEFF Research Database (Denmark)

    Nardello, Marco; Lapalme, James; Toppenberg, Gustav

    2015-01-01

    Innovation is becoming increasingly important for Enterprise Architecture (EA) teams. Consequently, it is crucial that tools be developed to assist Enterprise Architecture teams when evaluating how (and how well) they are supporting innovation within the context of their enterprise. To date very...

  3. Enterprise architecture for small and medium enterprise growth

    CSIR Research Space (South Africa)

    Jacobs, D

    2011-05-01

    Full Text Available with the growth of small enterprises into medium enterprises. SMEAG combines the existing growth stage model of Scott and Bruce, the Enterprise Architecture Framework by Hoogervorst, and the EA as Foundation for Business Execution Model by Ross, Weill...

  4. Enterprise architecture, a blueprint for enterprise logistics rollout

    CSIR Research Space (South Africa)

    Coetzee, J

    2013-08-01

    Full Text Available In this paper it is proposed that Enterprise architecture in principle develops the Logistic Support model for systems on System Hierarchical Level 6 and higher. The Enterprise architectural model is a blue print, like the DNA for biological systems...

  5. Information Systems for Enterprise Architecture

    Directory of Open Access Journals (Sweden)

    Oswaldo Moscoso Zea

    2014-03-01

    Full Text Available (Received: 2014/02/14 - Accepted: 2014/03/25Enterprise Architecture (EA has emerged as one of the most important topics to consider in Information System studies and has grown to become an essential business management activity to visualize and evaluate the future direction of a company. Nowadays in the market there are several software tools that support Enterprise Architects to work with EA. In order to decrease the risk of purchasing software tools that do not fulfill stakeholder´s needs is important to assess the software before making an investment. In this paper a literature review of the state of the art of EA will be done. Furthermore evaluation initiatives and existing information systems are analyzed which can support decision makers in the appropriate software tools for their companies.

  6. Enterprise architecture approach to mining companies engineering

    Directory of Open Access Journals (Sweden)

    Ilin’ Igor

    2017-01-01

    Full Text Available As Russian economy is still largely oriented on commodities production, there are a lot of cities where mining and commodity-oriented enterprises are the backbone of city economy. The mentioned enterprises mostly define the life quality of citizens in such cities, thus there are high requirements for engineering of city-forming enterprises. The paper describes the enterprise architecture approach for management system engineering of the mining enterprises. The paper contains the model of the mining enterprise architecture, the approach to the development and implementation of an integrated management system based on the concept of enterprise architecture and the structure of information systems and information technology infrastructure of the mining enterprise.

  7. Effectively Managing the Air Force Enterprise Architecture

    National Research Council Canada - National Science Library

    Sharkey, Jamie P

    2005-01-01

    The Air Force is developing and implementing an enterprise architecture to meet the Clinger-Cohen Act's requirement that all federal agencies use an architecture to guide their information technology (IT) investments...

  8. Towards an Enterprise Architecture Benefits Measurement Instrument

    NARCIS (Netherlands)

    Dr.ir. Raymond Slot; Henk Plessius; Marlies Steenbergen, van

    2015-01-01

    Author supplied: Based on the Enterprise Architecture Value Framework (EAVF) - a generic framework to classify benefits of Enterprise Architecture (EA) - a measurement instrument for EA benefits has been developed and tested in a survey with 287 respondents. In this paper we present the results of

  9. Lightweight metrics for enterprise architecture analysis

    NARCIS (Netherlands)

    Singh, Prince Mayurank; van Sinderen, Marten J.; Abramowicz, Witold

    2015-01-01

    The role of an Enterprise Architecture model is not limited to a graphical representation of an organization and its dynamics. Rather, it is also a tool for analysis and rational decision making. If firms do not use their enterprise architecture model to aid decision making then they run the risk of

  10. Relating business modelling and enterprise architecture

    NARCIS (Netherlands)

    Meertens, Lucas Onno

    2013-01-01

    This thesis proposes a methodology for creating business models, evaluating them, and relating them to enterprise architecture. The methodology consists of several steps, leading from an organization’s current situation to a target situation, via business models and enterprise architecture.

  11. Enterprise architecture evaluation using architecture framework and UML stereotypes

    Directory of Open Access Journals (Sweden)

    Narges Shahi

    2014-08-01

    Full Text Available There is an increasing need for enterprise architecture in numerous organizations with complicated systems with various processes. Support for information technology, organizational units whose elements maintain complex relationships increases. Enterprise architecture is so effective that its non-use in organizations is regarded as their institutional inability in efficient information technology management. The enterprise architecture process generally consists of three phases including strategic programing of information technology, enterprise architecture programing and enterprise architecture implementation. Each phase must be implemented sequentially and one single flaw in each phase may result in a flaw in the whole architecture and, consequently, in extra costs and time. If a model is mapped for the issue and then it is evaluated before enterprise architecture implementation in the second phase, the possible flaws in implementation process are prevented. In this study, the processes of enterprise architecture are illustrated through UML diagrams, and the architecture is evaluated in programming phase through transforming the UML diagrams to Petri nets. The results indicate that the high costs of the implementation phase will be reduced.

  12. Understanding Enterprise Architecture with Topic Modeling

    DEFF Research Database (Denmark)

    Nardello, Marco; Møller, Charles; Gøtze, John

    2018-01-01

    The next 3 years will be more important than the last 50 due to the digital transformation across industries. Enterprise Architecture (EA), the discipline that should lead enterprise responses to disruptive forces, is far from ready to drive the next wave of change. The state of the art in the di......The next 3 years will be more important than the last 50 due to the digital transformation across industries. Enterprise Architecture (EA), the discipline that should lead enterprise responses to disruptive forces, is far from ready to drive the next wave of change. The state of the art...

  13. Teaching Case: Enterprise Architecture Specification Case Study

    Science.gov (United States)

    Steenkamp, Annette Lerine; Alawdah, Amal; Almasri, Osama; Gai, Keke; Khattab, Nidal; Swaby, Carval; Abaas, Ramy

    2013-01-01

    A graduate course in enterprise architecture had a team project component in which a real-world business case, provided by an industry sponsor, formed the basis of the project charter and the architecture statement of work. The paper aims to share the team project experience on developing the architecture specifications based on the business case…

  14. Smart logistics: an enterprise architecture perspective

    NARCIS (Netherlands)

    van Sinderen, Marten J.; Singh, Prince Mayurank; Wieringa, Roel J.

    Logistic enterprises are increasingly becoming smarter and more ecient by using real-time contextual data. A currently unsolved problem for small to medium sized logistic service providers (SMLSPs) is, how to use real time data in existing business processes & IT systems. Enterprise architecture can

  15. Relating business modelling and enterprise architecture

    OpenAIRE

    Meertens, Lucas Onno

    2013-01-01

    This thesis proposes a methodology for creating business models, evaluating them, and relating them to enterprise architecture. The methodology consists of several steps, leading from an organization’s current situation to a target situation, via business models and enterprise architecture. Currently, increasing amounts of businesses rely on IT systems to do their business. However, success rates of IT implementations projects are low. Difficulties exist in aligning existing IT systems with b...

  16. Information Age Architectures Must Be Enterprise Architecture

    National Research Council Canada - National Science Library

    Augustine, Thomas H

    2004-01-01

    ... understand what John Zachman calls Enterprise Physics. From his investigation of how other professions build complex things he was able to generalize the interaction of all these people into a simple schema...

  17. RESILIENCE AND ENTERPRISE ARCHITECTURE IN SMES

    Directory of Open Access Journals (Sweden)

    Rui Gomes

    2015-12-01

    Full Text Available Considering that SMEs need to embrace the drivers of resilience and that a well-defined and readily available Enterprise Architecture (EA supports enterprise integration by enabling the common view of business processes, data and systems across the enterprise and its partners, we can say that EA is one of the tracks making resilience predictable and it should support and collaborate with other resilience tracks. However, the EA frameworks do not give relevance to the activities that contribute most to business resilience, so this paper aims to clarify the dimensions and the activities related to the development of an EA and the touching points with other enterprise wide processes in order to guarantee that resilience requirements are met in SMEs. For this I propose an approach of ecological adaptation, and four architectures: business, organizational, information, and technological, although this paper only presents the Business and Organizational Architectures.

  18. Force.com enterprise architecture

    CERN Document Server

    Fawcett, Andrew

    2014-01-01

    This book is for advanced Force.com developers and architects who need to understand the Salesforce platform from the perspective of enterprise-level requirements. You should have an existing understanding of Apex and Visualforce. Those familiar with other enterprise software ecosystems will also find this book ideal as they adopt Force.com.

  19. Enterprise Architecture in the Company Management Framework

    Directory of Open Access Journals (Sweden)

    Bojinov Bojidar Violinov

    2016-11-01

    Full Text Available The study aims to explore the role and importance of the concept of enterprise architecture in modern company management. For this purpose it clarifies the nature, scope, components of the enterprise architecture and relationships within it using the Zachman model. Based on the critical analysis of works by leading scientists, there presented a definition of enterprise architecture as a general description of all elements of strategic management of the company combined with description of its organizational, functional and operational structure, including the relationship between all tangible and intangible resources essential for its normal functioning and development. This in turn enables IT enterprise architecture to be defined as a set of corporate IT resources (hardware, software and technology, their interconnection and integration within the overall architecture of the company, as well as their formal description, methods and tools for their modeling and management in order to achieve strategic business goals of the organization. In conclusion the article summarizes the significance and role of enterprise architecture for strategic management of the company in today’s digital economy. The study underlines the importance of an integrated multidisciplinary approach to the work of a contemporary company, and the need for adequate matching and alignment of IT with business priorities and objectives of the company.

  20. The BWS Open Business Enterprise System Architecture

    Directory of Open Access Journals (Sweden)

    Cristian IONITA

    2011-01-01

    Full Text Available Business process management systems play a central role in supporting the business operations of medium and large organizations. This paper analyses the properties current business enterprise systems and proposes a new application type called Open Business Enterprise System. A new open system architecture called Business Workflow System is proposed. This architecture combines the instruments for flexible data management, business process management and integration into a flexible system able to manage modern business operations. The architecture was validated by implementing it into the DocuMentor platform used by major companies in Romania and US. These implementations offered the necessary data to create and refine an enterprise integration methodology called DMCPI. The final section of the paper presents the concepts, stages and techniques employed by the methodology.

  1. The architecture of enterprise hospital information system.

    Science.gov (United States)

    Lu, Xudong; Duan, Huilong; Li, Haomin; Zhao, Chenhui; An, Jiye

    2005-01-01

    Because of the complexity of the hospital environment, there exist a lot of medical information systems from different vendors with incompatible structures. In order to establish an enterprise hospital information system, the integration among these heterogeneous systems must be considered. Complete integration should cover three aspects: data integration, function integration and workflow integration. However most of the previous design of architecture did not accomplish such a complete integration. This article offers an architecture design of the enterprise hospital information system based on the concept of digital neural network system in hospital. It covers all three aspects of integration, and eventually achieves the target of one virtual data center with Enterprise Viewer for users of different roles. The initial implementation of the architecture in the 5-year Digital Hospital Project in Huzhou Central hospital of Zhejiang Province is also described.

  2. Addressing Cloud Computing in Enterprise Architecture: Issues and Challenges

    OpenAIRE

    Khan, Khaled; Gangavarapu, Narendra

    2009-01-01

    This article discusses how the characteristics of cloud computing affect the enterprise architecture in four domains: business, data, application and technology. The ownership and control of architectural components are shifted from organisational perimeters to cloud providers. It argues that although cloud computing promises numerous benefits to enterprises, the shifting control from enterprises to cloud providers on architectural components introduces several architectural challenges. The d...

  3. Enterprise Architecture Analysis with XML

    OpenAIRE

    Boer, Frank; Bonsangue, Marcello; Jacob, Joost; Stam, A.; Torre, Leon

    2005-01-01

    htmlabstractThis paper shows how XML can be used for static and dynamic analysis of architectures. Our analysis is based on the distinction between symbolic and semantic models of architectures. The core of a symbolic model consists of its signature that specifies symbolically its structural elements and their relationships. A semantic model is defined as a formal interpretation of the symbolic model. This provides a formal approach to the design of architectural description languages and a g...

  4. Enterprise Architecture Analysis with XML

    NARCIS (Netherlands)

    F.S. de Boer (Frank); M.M. Bonsangue (Marcello); J.F. Jacob (Joost); A. Stam; L.W.N. van der Torre (Leon)

    2005-01-01

    htmlabstractThis paper shows how XML can be used for static and dynamic analysis of architectures. Our analysis is based on the distinction between symbolic and semantic models of architectures. The core of a symbolic model consists of its signature that specifies symbolically its structural

  5. Vztah Enterprise Architecture a strategického managementu

    OpenAIRE

    Vašíček, Václav

    2009-01-01

    Enterprise Architecture is so far the highest development step in IT's architectural description of enterprises. At the beginning, just technological architecture existed. However, with the quickly growing complexity of IT other domains occurred, that had to be described. Information or application architectures can serve as examples. IT then realized, that it needed to add to its IT architectures a business view and consequently the discipline Enterprise Architecture came into being. Strateg...

  6. A goal-oriented requirements modelling language for enterprise architecture

    NARCIS (Netherlands)

    Quartel, Dick; Engelsman, W.; Jonkers, Henk; van Sinderen, Marten J.

    2009-01-01

    Methods for enterprise architecture, such as TOGAF, acknowledge the importance of requirements engineering in the development of enterprise architectures. Modelling support is needed to specify, document, communicate and reason about goals and requirements. Current modelling techniques for

  7. Enterprise Architecture : Management tool and blueprint for the organization

    NARCIS (Netherlands)

    Jonkers, Henk; Lankhorst, Marc M.; ter Doest, Hugo W.L.; Arbab, Farhad; Bosma, Hans; Wieringa, Roelf J.

    2006-01-01

    This is an editorial to a special issue of ISF on enterprise architecture.We define the concept of enterprise architecture, notivate its importance, and then introduce the papers in this special issue.

  8. Maturity and effectiveness of enterprise architecture

    NARCIS (Netherlands)

    Steenbergen, Marlies van

    2011-01-01

    Because of the need for continuous change, many organizations face an increasing complexity in their information systems portfolio. One of the answers to this increase in complexity, is the introduction of enterprise architecture (EA): the development and application of a consistent set of

  9. Exploring Enterprise Architecture Evaluation Practices

    DEFF Research Database (Denmark)

    Andersen, Peter; Carugati, Andrea; Grue Sørensen, Morten

    2015-01-01

    EA evaluation has received very little attention in academic publications on EA. While EA evaluation to some extent has been described in the literature, the different ways of evaluating architecture have mainly used a top-down approach deriving measures from theory rather than a bottom-up approa...

  10. Impact of Enterprise Architecture on Architecture Agility and Coherence

    Science.gov (United States)

    Abaas, Kanari

    2009-01-01

    IT has permeated to the very roots of organizations and has an ever increasingly important role in the achievement of overall corporate objectives and business strategies. This paper presents an approach for evaluating the impact of existing Enterprise Architecture (EA) implementations. The papers answers questions such as: What are the challenges…

  11. A new architecture for enterprise information systems.

    Science.gov (United States)

    Covvey, H D; Stumpf, J J

    1999-01-01

    Irresistible economic and technical forces are forcing healthcare institutions to develop regionalized services such as consolidated or virtual laboratories. Technical realities, such as the lack of an enabling enterprise-level information technology (IT) integration infrastructure, the existence of legacy systems, and non-existent or embryonic enterprise-level IT services organizations, are delaying or frustrating the achievement of the desired configuration of shared services. On attempting to address this matter, we discover that the state-of-the-art in integration technology is not wholly adequate, and itself becomes a barrier to the full realization of shared healthcare services. In this paper we report new work from the field of Co-operative Information Systems that proposes a new architecture of systems that are intrinsically cooperation-enabled, and we extend this architecture to both the regional and national scales.

  12. Enterprise Architecture - New business value perspectives

    OpenAIRE

    de Vries, M.; van Rensburg, A.C. J

    2008-01-01

    ENGLISH ABSTRACT: Organisations today are characterised by conglomerate organisation structures that evolve through mergers and acquisitions. Corporate offices need to add superior knowledge and skills to ensure that the collection of diverse businesses is operating as more than independent units. A new management approach is required to create synergies between the diverse businesses, their processes and system landscapes. Enterprise Architecture (EA) creates value on a corporate le...

  13. Enterprise Architecture Data Pada Hotel ABC

    OpenAIRE

    Soesatyo, Stephanie; Wibowo, Adi; Handojo, Andreas

    2015-01-01

    Hotel ABC is a company engaged in hospitality management, i.e. room rental, rental of meeting rooms and coffee shop. Hotel ABC has a branch that has the same specifications of the hotel. In business process, Hotel ABC has information systems to support existing business processes. However, existing information systems have not been integrated as a whole. Based on the condition stated above, analysis and design of enterprise architecture information system is created for the company. The proce...

  14. VERAM: Virtual Enterprise Reference Architecture and Methodology

    DEFF Research Database (Denmark)

    Zwegers, Arian; Tølle, Martin; Vesterager, Johan

    2003-01-01

    Nowadays, enterprises cooperate more extensively with other enterprises during the entire product life cycle. Temporary alliances between various enterprises emerge such as those in Virtual Enterprises. However, many enterprises experience difficulties in the formation and operation of virtual en...

  15. Towards a framework for managing enterprise architecture acceptance / Sonja Gilliland

    OpenAIRE

    Gilliland, Sonja

    2014-01-01

    An enterprise is a complex and changing entity, which is managed and maintained by humans. Enterprise architecture has been identified as an organisational strategy designed to assist enterprises with the understanding of complexity and the management of change. Acceptance, implementation and maintenance of enterprise architecture in organisations are complex and time-consuming. Work roles, responsibilities, common vocabulary, and buy-in are some of the cooperative human factors of stakeholde...

  16. How Enterprise Architecture Maturity Enables Post-merger IT Integration

    DEFF Research Database (Denmark)

    Törmer, Robert Lorenz; Henningsson, Stefan

    2017-01-01

    advances the argument that a company’s pre-existing Enterprise Architecture decisively shapes the capability to implement post-merger IT integration and subsequently realize benefits from M&A. Our multiple-case study investigates three acquisition cases and develops an explanatory theory of how Enterprise...... Architecture maturity enables the implementation of distinct integration strategies. The results do not only enrich the academic literature on M&A, but also show the strategic value of Enterprise Architecture maturity....

  17. Fostering Enterprise Architecture Education and Training with the Enterprise Architecture Competence Framework

    Science.gov (United States)

    Tambouris, Efthimios; Zotou, Maria; Kalampokis, Evangelos; Tarabanis, Konstantinos

    2012-01-01

    Enterprise architecture (EA) implementation refers to a set of activities ultimately aiming to align business objectives with information technology infrastructure in an organization. EA implementation is a multidisciplinary, complicated and endless process, hence, calls for adequate education and training programs that will build highly skilled…

  18. Enterprise Architecture in the Supply Chain

    DEFF Research Database (Denmark)

    Tambo, Torben; Koch, Christian

    2010-01-01

    Information systems in supply chain management (SCM) is common, bringing architecture on the agenda . The paper uses three perspectives on enterprise architecture (EA) in the supply chain: The correlation view, the remote view and the institutional view. It is shown that the EA in the domain...... of supply chain has to meet quite a complicated set of demands. Coherency Management (CM) for the aligning of business processes and underlying technology is used by proposing three parameters for EA: Alignment, agility and assurance. Alignment addresses the depth of business vs. technology correspondence...... is presented and discussed. The case outlines potentials for an enhanced alignment and coherence between management, business processes and underlying information system; innovation is led by tighter integration with business partners, higher versatility in the adaption to formal business requirements...

  19. Enterprise architecture patterns practical solutions for recurring IT-architecture problems

    CERN Document Server

    Perroud, Thierry

    2013-01-01

    Every enterprise architect faces similar problems when designing and governing the enterprise architecture of a medium to large enterprise. Design patterns are a well-established concept in software engineering, used to define universally applicable solution schemes. By applying this approach to enterprise architectures, recurring problems in the design and implementation of enterprise architectures can be solved over all layers, from the business layer to the application and data layer down to the technology layer.Inversini and Perroud describe patterns at the level of enterprise architecture

  20. Integration issues in virtual enterprises supported by an architectural framework

    DEFF Research Database (Denmark)

    Zwegers, Arian; Hannus, Matti; Tølle, Martin

    2001-01-01

    enterprises, especially concerning integration issues. This paper lays down an architectural framework, called VERAM, which aims to support the set-up and operation of virtual enterprises. Five different levels of integration are identified. They should all be addressed during the formation of a virtual......Nowadays, enterprises cooperate more extensively with other enterprises during the entire product life cycle. Temporary alliances between various enterprises emerge such as those in Virtual Enterprises. However, many enterprises experience difficulties in the formation and operation of virtual...

  1. Exploring the future of Enterprise Architecture: A Zachman perspective

    CSIR Research Space (South Africa)

    Lapalme, J

    2015-07-01

    Full Text Available architecture as a solution for overcoming identified challenges, the Zachman Enterprise Architecture Framework is used to guide and structure the discussion. The paper presents the “Grand Challenges” and discusses promising theories and models for addressing...

  2. INFORMATION SYSTEM STRATEGIC PLANNING WITH ENTERPRISE ARCHITECTURE PLANNING

    Directory of Open Access Journals (Sweden)

    Lola Yorita Astri

    2013-05-01

    Full Text Available An integrated information system is needed in an enterprise to support businessprocesses run by an enterprise. Therefore, to develop information system can use enterprisearchitecture approach which can define strategic planning of enterprise information system. SMPNegeri 1 Jambi can be viewed as an enterprise because there are entities that should be managedthrough an integrated information system. Since there has been no unification of different elementsin a unity yet, enterprise architecture model using Enterprise Architecture Planning (EAP isneeded which will obtain strategic planning of enterprise information system in SMP Negeri 1Jambi. The goal of strategic planning of information system with Enterprise Architecture Planning(EAP is to define primary activities run by SMP Negeri 1 Jambi and support activities supportingprimary activities. They can be used as a basis for making data architecture which is the entities ofapplication architecture. At last, technology architecture is designed to describe technology neededto provide environment for data application. The plan of implementation is the activity plan madeto implemented architectures by enterprise.

  3. Application of Data Architecture Model in Enterprise Management

    Directory of Open Access Journals (Sweden)

    Shi Song

    2017-01-01

    Full Text Available Today is in the era of rapid development of information, data volume of high-speed expansion, it is difficult in the previous system for communication, sharing and integration. In order to integrate data resources, eliminate the “information island”, build enterprise development blueprints, people gradually realize the importance of top design. Many enterprises for their own development to establish their own enterprise architecture of the top design, and as its core data architecture model is also reflected in different industries according to different development. This paper mainly studies the data architecture model, expounds the role of data architecture model and its relationship.

  4. Space Internet Architectures and Technologies for NASA Enterprises

    Science.gov (United States)

    Bhasin, Kul; Hayden, Jeffrey L.

    2001-01-01

    NASA's future communications services will be supplied through a space communications network that mirrors the terrestrial Internet in its capabilities and flexibility. The notional requirements for future data gathering and distribution by this Space Internet have been gathered from NASA's Earth Science Enterprise (ESE), the Human Exploration and Development in Space (HEDS), and the Space Science Enterprise (SSE). This paper describes a communications infrastructure for the Space Internet, the architectures within the infrastructure, and the elements that make up the architectures. The architectures meet the requirements of the enterprises beyond 2010 with Internet 'compatible technologies and functionality. The elements of an architecture include the backbone, access, inter-spacecraft and proximity communication parts. From the architectures, technologies have been identified which have the most impact and are critical for the implementation of the architectures.

  5. Predefined three tier business intelligence architecture in healthcare enterprise.

    Science.gov (United States)

    Wang, Meimei

    2013-04-01

    Business Intelligence (BI) has caused extensive concerns and widespread use in gathering, processing and analyzing data and providing enterprise users the methodology to make decisions. Different from traditional BI architecture, this paper proposes a new BI architecture, Top-Down Scalable BI architecture with defining mechanism for enterprise decision making solutions and aims at establishing a rapid, consistent, and scalable multiple applications on multiple platforms of BI mechanism. The two opposite information flows in our BI architecture offer the merits of having the high level of organizational prospects and making full use of the existing resources. We also introduced the avg-bed-waiting-time factor to evaluate hospital care capacity.

  6. Enterprise Architecture-Based Risk and Security Modelling and Analysis

    NARCIS (Netherlands)

    Jonkers, Henk; Quartel, Dick; Kordy, Barbara; Ekstedt, Mathias; Seong Kim, Deng

    2016-01-01

    The growing complexity of organizations and the increasing number of sophisticated cyber attacks asks for a systematic and integral approach to Enterprise Risk and Security Management (ERSM). As enterprise architecture offers the necessary integral perspective, including the business and IT aspects

  7. An Enterprise Security Program and Architecture to Support Business Drivers

    OpenAIRE

    Brian Ritchot

    2013-01-01

    This article presents a business-focused approach to developing and delivering enterprise security architecture that is focused on enabling business objectives while providing a sensible and balanced approach to risk management. A balanced approach to enterprise security architecture can create the important linkages between the goals and objectives of a business, and it provides appropriate measures to protect the most critical assets within an organization while accepting risk where appropr...

  8. Architectural Modeling for the Future Internet-enabled Enterprise (AMFInE) Workshop

    NARCIS (Netherlands)

    van Sinderen, Marten J.; Zelm, Martin; Sanchis, Raquel; Poler, Raul; Doumeingts, Guy

    2012-01-01

    In order for future enterprises to make effective use of the Future Internet, it is necessary that their Enterprise Architecture aligns with the Future Internet Architecture. An Enterprise Architecture is a comprehensive architecture description that spans enterprise and technology aspects, to allow

  9. ENTERPRISE ARCHITECTURE – NEW BUSINESS VALUE PERSPECTIVES

    Directory of Open Access Journals (Sweden)

    M. De Vries

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: Organisations today are characterised by conglomerate organisation structures that evolve through mergers and acquisitions. Corporate offices need to add superior knowledge and skills to ensure that the collection of diverse businesses is operating as more than independent units. A new management approach is required to create synergies between the diverse businesses, their processes and system landscapes. Enterprise Architecture (EA creates value on a corporate level by facilitating process/information technology alignment and synergy between different strategic business units (SBUs. Unfortunately many EA implementations seemed to fail owing to a short-term financial focus and measurement.
    This article explores the possibilities of linking EA to a corporate balanced scorecard (BSC to demonstrate its long-term financial improvement capabilities in supporting the business strategy. The aim is to use the corporate BSC context to direct EA objectives in creating contextualised value for a specific enterprise.

    AFRIKAANSE OPSOMMING: Organisasies word vandag gekenmerk deur konglomeraatorganisasiestrukture wat groei deur middel van die samesmelting en oorname van ander organisasies. Korporaatkantore sal hoër-staande kennis en vaardighede moet toevoeg om te verseker dat die versameling van diverse besighede groter is as wanneer hul onafhanklik van mekaar opereer. ’n Nuwe bestuursbenadering word benodig om sinergieë tussen die diverse besighede, hul prosesse en stelsel-landskappe te skep. Ondernemingsargitektuur (OA skep waarde op ’n korporatiewe vlak deur die fasilitering van proses/inligtingtegnologiebelyning en sinergie-skepping tussen verskillende strategiese besigheidseenhede. Ongelukkig faal vele OA projekte weens ’n kort-termyn finansiële fokus en prestasie-meting.
    Hierdie artikel ondersoek die moontlikheid om OA te koppel aan ’n korporatiewe gebalanseerde telkaart (KBT om sodanig OA se lang

  10. Performance evaluation of enterprise architecture using fuzzy sequence diagram

    Directory of Open Access Journals (Sweden)

    Mohammad Atasheneh

    2014-01-01

    Full Text Available Developing an Enterprise Architecture is a complex task and to control the complexity of the regulatory framework we need to measure the relative performance of one system against other available systems. On the other hand, enterprise architecture cannot be organized without the use of a logical structure. The framework provides a logical structure for classifying architectural output. Among the common architectural framework, the C4ISR framework and methodology of the product is one of the most popular techniques. In this paper, given the existing uncertainties in system development and information systems, a new version of UML called Fuzzy-UML is proposed for enterprise architecture development based on fuzzy Petri nets. In addition, the performance of the system is also evaluated based on Fuzzy sequence diagram.

  11. Relating business intelligence and enterprise architecture - A method for combining operational data with architectural metadata

    NARCIS (Netherlands)

    Veneberg, R.K.M.; Iacob, Maria Eugenia; van Sinderen, Marten J.; Bodenstaff, L.

    Combining enterprise architecture and operational data is complex (especially when considering the actual ‘matching’ of data with enterprise architecture elements), and little has been written on how to do this. In this paper we aim to fill this gap, and propose a method to combine operational data

  12. Custom-made cloud enterprise architecture for small, medium and micro enterprises

    CSIR Research Space (South Africa)

    Mvelase, P

    2011-07-01

    Full Text Available architecture based on the concept of virtual enterprise at both business and technology levels. The business level comprises of organisational models, process models, skills, and competences whereas the technology level comprises of IT resources....

  13. Development of enterprise architecture management methodology for teaching purposes

    Directory of Open Access Journals (Sweden)

    Dmitry V. Kudryavtsev

    2017-01-01

    Full Text Available Enterprise architecture is considered as a certain object of management, providing in business a general view of the enterprise and the mutual alignment of parts of this enterprise into a single whole, and as the discipline that arose based on this object. The architectural approach to the modeling and design of the enterprise originally arose in the field of information technology and was used to design information systems and technical infrastructure, as well as formalize business requirements. Since the early 2000’s enterprise architecture is increasingly used in organizational development and business transformation projects, especially if information technologies are involved. Enterprise architecture allows describing, analyzing and designing the company from the point of view of its structure, functioning and goal setting (motivation.In the context of this approach, the enterprise is viewed as a system of services, processes, goals and performance indicators, organizational units, information systems, data, technical facilities, etc. Enterprise architecture implements the idea of a systematic approach to managing and changing organizations in the digital economy where business is strongly dependent on information technologies.This increases the relevance of the suggested approach at the present time, when companies need to create and successfully implement a digital business strategy.Teaching enterprise architecture in higher educational institutions is a difficult task due to the interdisciplinary of this subject, its generalized nature and close connection with practical experience. In addition, modern enterprise architecture management methodologies are complex for students and contain many details that are relevant for individual situations.The paper proposes a simplified methodology for enterprise architecture management, which on the one hand will be comprehensible to students, and on the other hand, it will allow students to apply

  14. Definition of an Object-Oriented Modeling Language for Enterprise Architecture

    OpenAIRE

    Lê, Lam Son; Wegmann, Alain

    2005-01-01

    In enterprise architecture, the goal is to integrate business resources and IT resources in order to improve an enterprises competitiveness. In an enterprise architecture project, the development team usually constructs a model that represents the enterprise: the enterprise model. In this paper, we present a modeling language for building such enterprise models. Our enterprise models are hierarchical object-oriented representations of the enterprises. This paper presents the foundations of o...

  15. What Enterprise Architecture and Enterprise Systems Usage Can and Can not Tell about Each Other

    NARCIS (Netherlands)

    Daneva, Maia; van Eck, Pascal; Rolland, C; Pastor, O; Cavarejo, J-L

    2007-01-01

    There is an increased awareness of the roles that enterprise architecture (EA) and enterprise systems (ES) play in today’s organizations. EA and ES usage maturity models are used to assess how well companies are capable of deploying these two concepts while striving to achieve strategic corporate

  16. What Enterprise Architecture and Enterprise Systems Usage Can and Can not Tell about Each Other

    NARCIS (Netherlands)

    Daneva, Maia; Rolland, C; Pastor, O; van Eck, Pascal; Cavarero, J.L.

    There is an increased awareness of the roles that enterprise architecture (EA) and enterprise systems (ES) play in today’s organizations. EA and ES usage maturity models are used to assess how well companies are capable of deploying these two concepts while striving to achieve strategic corporate

  17. What Enterprise Architecture and Enterprise Systems Usage Can and Can not Tell about Each Other

    NARCIS (Netherlands)

    Daneva, Maia; van Eck, Pascal

    There is an increased awareness of the roles that enterprise architecture (EA) and enterprise systems (ES) play in today's organizations. EA and ES usage maturity models are used to assess how well companies are capable of deploying these two concepts while striving to achieve strategic corporate

  18. An Agile Enterprise Regulation Architecture for Health Information Security Management

    Science.gov (United States)

    Chen, Ying-Pei; Hsieh, Sung-Huai; Chien, Tsan-Nan; Chen, Heng-Shuen; Luh, Jer-Junn; Lai, Jin-Shin; Lai, Feipei; Chen, Sao-Jie

    2010-01-01

    Abstract Information security management for healthcare enterprises is complex as well as mission critical. Information technology requests from clinical users are of such urgency that the information office should do its best to achieve as many user requests as possible at a high service level using swift security policies. This research proposes the Agile Enterprise Regulation Architecture (AERA) of information security management for healthcare enterprises to implement as part of the electronic health record process. Survey outcomes and evidential experiences from a sample of medical center users proved that AERA encourages the information officials and enterprise administrators to overcome the challenges faced within an electronically equipped hospital. PMID:20815748

  19. An agile enterprise regulation architecture for health information security management.

    Science.gov (United States)

    Chen, Ying-Pei; Hsieh, Sung-Huai; Cheng, Po-Hsun; Chien, Tsan-Nan; Chen, Heng-Shuen; Luh, Jer-Junn; Lai, Jin-Shin; Lai, Feipei; Chen, Sao-Jie

    2010-09-01

    Information security management for healthcare enterprises is complex as well as mission critical. Information technology requests from clinical users are of such urgency that the information office should do its best to achieve as many user requests as possible at a high service level using swift security policies. This research proposes the Agile Enterprise Regulation Architecture (AERA) of information security management for healthcare enterprises to implement as part of the electronic health record process. Survey outcomes and evidential experiences from a sample of medical center users proved that AERA encourages the information officials and enterprise administrators to overcome the challenges faced within an electronically equipped hospital.

  20. Aligning enterprise architecture with strategic planning

    NARCIS (Netherlands)

    Azevedo, Carlos L.B.; van Sinderen, Marten J.; Ferreira Pires, Luis; Andrade Almeida, João

    2015-01-01

    Strategic planning improves both the financial and behavioral performance of an enterprise. It helps the enterprise set priorities, focus capabilities and resources, strengthen operations, ensure that stakeholders are working toward common goals and assess and adjust the enterprise’s direction.

  1. Extending enterprise architecture modelling with business goals and requirements

    NARCIS (Netherlands)

    Engelsman, W.; Quartel, Dick; Jonkers, Henk; van Sinderen, Marten J.

    The methods for enterprise architecture (EA), such as The Open Group Architecture Framework, acknowledge the importance of requirements modelling in the development of EAs. Modelling support is needed to specify, document, communicate and reason about goals and requirements. The current modelling

  2. Travaux de l'Health Enterprise Architecture Laboratory (HEAL ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2010-06-03

    Journal articles. Position paper : researching and developing open architectures for national health information systems in developing African countries. Download PDF. Reports. Workshop narrative report : IDRC eHealth Enterprise Architecture Workshop, June 3, 2010. Download PDF. Studies. HEAL: Establishing a Health ...

  3. The application of enterprise reference architecture in the financial industry

    NARCIS (Netherlands)

    Harmsen van der Beek - Hamer, ten W.; Trienekens, J.J.M.; Grefen, P.W.P.J.; Aier, S.

    2012-01-01

    Abstract. Financial institutions are facing enormous challenges in business / IT alignment. Enterprise architecture (EA) is seen as key in addressing these challenges. Major issues still exist in EA design and realization. The concept of reference architecture is explored as one of the elements that

  4. From enterprise architecture to business models and back

    NARCIS (Netherlands)

    Iacob, Maria Eugenia; Meertens, Lucas Onno; Jonkers, H.; Quartel, Dick; Nieuwenhuis, Lambertus Johannes Maria; van Sinderen, Marten J.

    In this study, we argue that important IT change processes affecting an organization’s enterprise architecture are also mirrored by a change in the organization’s business model. An analysis of the business model may establish whether the architecture change has value for the business. Therefore, in

  5. Essential Layers, Artifacts, and Dependencies of Enterprise Architecture

    OpenAIRE

    Winter, Robert; Fischer, Ronny

    2007-01-01

    After a period where implementation speed was more important than integration, consistency and reduction of complexity, architectural considerations have become a key issue of information management in recent years again. Enterprise architecture is widely accepted as an essential mechanism for ensuring agility and consistency, compliance and efficiency. Although standards like TOGAF and FEAF have developed, however, there is no common agreement on which architecture layers, which artifact typ...

  6. Business model driven service architecture design for enterprise application integration

    OpenAIRE

    Gacitua-Decar, Veronica; Pahl, Claus

    2008-01-01

    Increasingly, organisations are using a Service-Oriented Architecture (SOA) as an approach to Enterprise Application Integration (EAI), which is required for the automation of business processes. This paper presents an architecture development process which guides the transition from business models to a service-based software architecture. The process is supported by business reference models and patterns. Firstly, the business process models are enhanced with domain model elements, applicat...

  7. Enterprise Information Architecture for Mission Development

    Science.gov (United States)

    Dutra, Jayne

    2007-01-01

    This slide presentation reviews the concept of an information architecture to assist in mission development. The integrate information architecture will create a unified view of the information using metadata and the values (i.e., taxonomy).

  8. Enterprise Architecture Integration in E-government

    NARCIS (Netherlands)

    Janssen, M.F.W.H.A.; Cresswell, A.

    2005-01-01

    Achieving goals of better integrated and responsive government services requires moving away from stand alone applications toward more comprehensive, integrated architectures. As a result there is mounting pressure to move from disparate systems operating in parallel toward a shared architecture

  9. The Perception of Human Resources Enterprise Architecture within the Department of Defense

    Science.gov (United States)

    Delaquis, Richard Serge

    2012-01-01

    The Clinger Cohen Act of 1996 requires that all major Federal Government Information Technology (IT) systems prepare an Enterprise Architecture prior to IT acquisitions. Enterprise Architecture, like house blueprints, represents the system build, capabilities, processes, and data across the enterprise of IT systems. Enterprise Architecture is used…

  10. Enterprise Architecture v systému řízení

    OpenAIRE

    Sládek, Pavel

    2008-01-01

    This thesis deals with subject of enterprise architecture management. Topcis covered are enterprise environment integration, enterprise architecture parts description and description of shift in enterprise architecture focus point. This trend can be described as shift from IT related activity for IT management through tool for IT and business alignment to the final state as a tool for business change implementation. There are four goals of this thesis. Description of enterprise architecture, ...

  11. PEMANFAATAN ENTERPRISE ARCHITECTURE PLANNING UNTUK PERENCANAAN STRATEGIS SISTEM INFORMASI

    Directory of Open Access Journals (Sweden)

    Kridanto Surendro

    2007-01-01

    Full Text Available In the endeavor to attain its goal, an enterprise strives to undertake challenges and changes of which strategies for effective measures and efficient resource usage become necessary. To this necessity, the role of information system for supporting and enhancing enterprise performance has become more strategic and widely established. This elicits mission for information system and advises a general course of action to give a unified direction for planning, implementation and control in alignment with enterprise business strategy. A planning that identifies enterprise's information requirement and possible innovations in technology utilization for enhancing enterprise performance is a first step to begin the fulfillment of information system mission. Such a planning can be satisfied by employing Enterprise Architecture Planning methodology, which is purposed to deliver data architecture, application architecture, technology architecture and implementation plan. Implementation plan is comprised of a sequence of application development and technology platform migration / acquisition. Such a sequence is elaborated further according to business aspect as a main drive, organizational aspect which addresses people who will be involved in implementation, information system and information technology environment aspect as an interface for existing and future systems, and application development aspect which interconnects one stage in the development sequence with another. Abstract in Bahasa Indonesia : Pencapaian tujuan suatu enterprise menghadapi berbagai tantangan serta perubahan yang memerlukan strategi untuk langkah-langkah efektif dan pemanfaatan sumber daya yang efisien. Salah satu strategi yang penting dan semakin banyak digunakan adalah pemanfaatan dan peningkatan dukungan sistem informasi bagi enterprise. Penerapan strategi ini mengembankan misi pada sistem informasi yang pemenuhannya memerlukan keterpaduan arah dalam perencanaan, pelaksanaan

  12. INTEGRATION OF VIRTUAL ENTERPRISES USING SERVICE ORIENTED ARCHITECTURE

    Directory of Open Access Journals (Sweden)

    Miladin Stefanovic

    2009-06-01

    Full Text Available Virtual enterprise integration (VEI is virtually the most critical success factor for making virtual enterprise (VE a real, competitive, and widely implemented organizational an d management concept. One of possible approaches in virtual enterprise integration is employment of web services. In this paper we will present process-oriented approach for developing an SOA for VEI. The general assumption of suggested approach is that service oriented architecture is based on business service and that business services mostly correspond to exchanged documentation in a real business system. CASE tool for web service specification is also presented.

  13. An Enterprise Security Program and Architecture to Support Business Drivers

    Directory of Open Access Journals (Sweden)

    Brian Ritchot

    2013-08-01

    Full Text Available This article presents a business-focused approach to developing and delivering enterprise security architecture that is focused on enabling business objectives while providing a sensible and balanced approach to risk management. A balanced approach to enterprise security architecture can create the important linkages between the goals and objectives of a business, and it provides appropriate measures to protect the most critical assets within an organization while accepting risk where appropriate. Through a discussion of information assurance, this article makes a case for leveraging enterprise security architectures to meet an organizations' need for information assurance. The approach is derived from the Sherwood Applied Business Security Architecture (SABSA methodology, as put into practice by Seccuris Inc., an information assurance integrator. An understanding of Seccuris’ approach will illustrate the importance of aligning security activities with high-level business objectives while creating increased awareness of the duality of risk. This business-driven approach to enterprise security architecture can help organizations change the perception of IT security, positioning it as a tool to enable and assure business success, rather than be perceived as an obstacle to be avoided.

  14. Developing Enterprise Architectures to Address the Enterprise Dilemma of Deciding What Should Be Sustained versus What Should Be Changed

    Science.gov (United States)

    Harrell, J. Michael

    2011-01-01

    Enterprise architecture is a relatively new concept that arose in the latter half of the twentieth century as a means of managing the information technology resources within the enterprise. Borrowing from the disciplines of brick and mortar architecture, software engineering, software architecture, and systems engineering, the enterprise…

  15. Advanced Ground Systems Maintenance Enterprise Architecture Project

    Science.gov (United States)

    Perotti, Jose M. (Compiler)

    2015-01-01

    The project implements an architecture for delivery of integrated health management capabilities for the 21st Century launch complex. The delivered capabilities include anomaly detection, fault isolation, prognostics and physics based diagnostics.

  16. An Enterprise Information System Data Architecture Guide

    National Research Council Canada - National Science Library

    Lewis, Grace

    2001-01-01

    Data architecture defines how data is stored, managed, and used in a system. It establishes common guidelines for data operations that make it impossible to predict, model, gauge, or control the flow of data in the system...

  17. Health Enterprise Architecture Laboratory (HEAL) | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... world-class training program for health informatics researchers, and a test bed for ... to strengthen the contribution of Southern researchers to this growing field. ... Position paper : researching and developing open architectures for national ...

  18. Fast tracking ICT infrastructure requirements and design, based on Enterprise Reference Architecture and matching Reference Models

    DEFF Research Database (Denmark)

    Bernus, Peter; Baltrusch, Rob; Vesterager, Johan

    2002-01-01

    The Globemen Consortium has developed the virtual enterprise reference architecture and methodology (VERAM), based on GERAM and developed reference models for virtual enterprise management and joint mission delivery. The planned virtual enterprise capability includes the areas of sales...

  19. Data accuracy assessment using enterprise architecture

    Science.gov (United States)

    Närman, Per; Holm, Hannes; Johnson, Pontus; König, Johan; Chenine, Moustafa; Ekstedt, Mathias

    2011-02-01

    Errors in business processes result in poor data accuracy. This article proposes an architecture analysis method which utilises ArchiMate and the Probabilistic Relational Model formalism to model and analyse data accuracy. Since the resources available for architecture analysis are usually quite scarce, the method advocates interviews as the primary data collection technique. A case study demonstrates that the method yields correct data accuracy estimates and is more resource-efficient than a competing sampling-based data accuracy estimation method.

  20. Extending enterprise architecture modelling with business goals and requirements

    Science.gov (United States)

    Engelsman, Wilco; Quartel, Dick; Jonkers, Henk; van Sinderen, Marten

    2011-02-01

    The methods for enterprise architecture (EA), such as The Open Group Architecture Framework, acknowledge the importance of requirements modelling in the development of EAs. Modelling support is needed to specify, document, communicate and reason about goals and requirements. The current modelling techniques for EA focus on the products, services, processes and applications of an enterprise. In addition, techniques may be provided to describe structured requirements lists and use cases. Little support is available however for modelling the underlying motivation of EAs in terms of stakeholder concerns and the high-level goals that address these concerns. This article describes a language that supports the modelling of this motivation. The definition of the language is based on existing work on high-level goal and requirements modelling and is aligned with an existing standard for enterprise modelling: the ArchiMate language. Furthermore, the article illustrates how EA can benefit from analysis techniques from the requirements engineering domain.

  1. Trends in Governmental Enterprise Architecture: Reviewing National EA Programs

    DEFF Research Database (Denmark)

    Gøtze, John; Christiansen, Peter Engelund

    2007-01-01

    This article is the first in a series of three, where we will analyze and evaluate governmental enterprise architecture policies and practices from an international perspective. This first article presents the overall findings from an international study, we have made about governmental EA, and i...

  2. Can enterprise architectures reduce failure in development projects?

    NARCIS (Netherlands)

    Janssen, M.F.W.H.A.; Klievink, B.

    2012-01-01

    Purpose: Scant attention has been given to the role of enterprise architecture (EA) in relationship to risk management in information system development projects. Even less attention has been given to the inter-organizational setting. The aim of this paper is to better understand this relationship.

  3. Travaux de l'Health Enterprise Architecture Laboratory (HEAL ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Extrants. Articles de revue. Position paper : researching and developing enterprise architectures for health information systems in developing African countries. Téléchargez le PDF ... L'Initiative des conseils subventionnaires de la recherche scientifique en Afrique subsaharienne remporte le prix de la diplomatie scientifique.

  4. Weighted Components of i-Government Enterprise Architecture

    Science.gov (United States)

    Budiardjo, E. K.; Firmansyah, G.; Hasibuan, Z. A.

    2017-01-01

    Lack of government performance, among others due to the lack of coordination and communication among government agencies. Whilst, Enterprise Architecture (EA) in the government can be use as a strategic planning tool to improve productivity, efficiency, and effectivity. However, the existence components of Government Enterprise Architecture (GEA) do not show level of importance, that cause difficulty in implementing good e-government for good governance. This study is to explore the weight of GEA components using Principal Component Analysis (PCA) in order to discovered an inherent structure of e-government. The results show that IT governance component of GEA play a major role in the GEA. The rest of components that consist of e-government system, e-government regulation, e-government management, and application key operational, contributed more or less the same. Beside that GEA from other countries analyzes using comparative base on comon enterprise architecture component. These weighted components use to construct i-Government enterprise architecture. and show the relative importance of component in order to established priorities in developing e-government.

  5. From service-oriented architecture to service-oriented enterprise

    NARCIS (Netherlands)

    van Sinderen, Marten J.; Cordeiro, J.; Ivanov, I.; Shishkov, Boris

    2009-01-01

    Service-Oriented Architecture (SOA) was originally motivated by enterprise demands for better business-technology alignment and higher flexibility and reuse. SOA evolved from an initial set of ideas and principles to Web services (WS) standards now widely accepted by industry. The next phase of SOA

  6. Evaluating the Effectiveness of Reference Models in Federating Enterprise Architectures

    Science.gov (United States)

    Wilson, Jeffery A.

    2012-01-01

    Agencies need to collaborate with each other to perform missions, improve mission performance, and find efficiencies. The ability of individual government agencies to collaborate with each other for mission and business success and efficiency is complicated by the different techniques used to describe their Enterprise Architectures (EAs).…

  7. A framework for creating pattern languages for enterprise architecture

    CSIR Research Space (South Africa)

    Kotzé, P

    2012-10-01

    Full Text Available The use of patterns and pattern languages in enterprise architecture (EA) is a relatively novel concept. Although both the concepts of patterns and EA are over 30 years old, the notion of design patterns is hardly applied to EA. There is a lack...

  8. Information Systems’ Portfolio: Contributions of Enterprise and Process Architecture

    Directory of Open Access Journals (Sweden)

    Silvia Fernandes

    2017-09-01

    Full Text Available We are witnessing a need for a quick and intelligent reaction from organizations to the level and speed of change in business processes.New information technologies and systems (IT/IS are challenging business models and products. One of the great shakes comes from the online and/or mobile apps and platforms.These are having a tremendous impact in launching innovative and competitive services through the combination of digital and physical features. This leads to actively rethink enterprise information systems’ portfolio, its management and suitability. One relevant way for enterprises to manage their IT/IS in order to cope with those challenges is enterprise and process architecture. A decision-making culture based on processes helps to understand and define the different elements that shape an organization and how those elements inter-relate inside and outside it. IT/IS portfolio management requires an increasing need of modeling data and process flows for better discerning and acting at its selection and alignment with business goals. The new generation of enterprise architecture (NGEA helps to design intelligent processes that answer quickly and creatively to new and challenging trends. This has to be open, agile and context-aware to allow well-designed services that match users’ expectations. This study includes two real cases/problems to solve quickly in companies and solutions are presented in line with this architectural approach.

  9. Motion/imagery secure cloud enterprise architecture analysis

    Science.gov (United States)

    DeLay, John L.

    2012-06-01

    Cloud computing with storage virtualization and new service-oriented architectures brings a new perspective to the aspect of a distributed motion imagery and persistent surveillance enterprise. Our existing research is focused mainly on content management, distributed analytics, WAN distributed cloud networking performance issues of cloud based technologies. The potential of leveraging cloud based technologies for hosting motion imagery, imagery and analytics workflows for DOD and security applications is relatively unexplored. This paper will examine technologies for managing, storing, processing and disseminating motion imagery and imagery within a distributed network environment. Finally, we propose areas for future research in the area of distributed cloud content management enterprises.

  10. Hospital enterprise Architecture Framework (Study of Iranian University Hospital Organization).

    Science.gov (United States)

    Haghighathoseini, Atefehsadat; Bobarshad, Hossein; Saghafi, Fatehmeh; Rezaei, Mohammad Sadegh; Bagherzadeh, Nader

    2018-06-01

    Nowadays developing smart and fast services for patients and transforming hospitals to modern hospitals is considered a necessity. Living in the world inundated with information systems, designing services based on information technology entails a suitable architecture framework. This paper aims to present a localized enterprise architecture framework for the Iranian university hospital. Using two dimensions of implementation and having appropriate characteristics, the best 17 enterprises frameworks were chosen. As part of this effort, five criteria were selected according to experts' inputs. According to these criteria, five frameworks which had the highest rank were chosen. Then 44 general characteristics were extracted from the existing 17 frameworks after careful studying. Then a questionnaire was written accordingly to distinguish the necessity of those characteristics using expert's opinions and Delphi method. The result showed eight important criteria. In the next step, using AHP method, TOGAF was chosen regarding having appropriate characteristics and the ability to be implemented among reference formats. In the next step, enterprise architecture framework was designed by TOGAF in a conceptual model and its layers. For determining architecture framework parts, a questionnaire with 145 questions was written based on literature review and expert's opinions. The results showed during localization of TOGAF for Iran, 111 of 145 parts were chosen and certified to be used in the hospital. The results showed that TOGAF could be suitable for use in the hospital. So, a localized Hospital Enterprise Architecture Modelling is developed by customizing TOGAF for an Iranian hospital at eight levels and 11 parts. This new model could be used to be performed in other Iranian hospitals. Copyright © 2018 Elsevier B.V. All rights reserved.

  11. Enterprise architecture availability analysis using fault trees and stakeholder interviews

    Science.gov (United States)

    Närman, Per; Franke, Ulrik; König, Johan; Buschle, Markus; Ekstedt, Mathias

    2014-01-01

    The availability of enterprise information systems is a key concern for many organisations. This article describes a method for availability analysis based on Fault Tree Analysis and constructs from the ArchiMate enterprise architecture (EA) language. To test the quality of the method, several case-studies within the banking and electrical utility industries were performed. Input data were collected through stakeholder interviews. The results from the case studies were compared with availability of log data to determine the accuracy of the method's predictions. In the five cases where accurate log data were available, the yearly downtime estimates were within eight hours from the actual downtimes. The cost of performing the analysis was low; no case study required more than 20 man-hours of work, making the method ideal for practitioners with an interest in obtaining rapid availability estimates of their enterprise information systems.

  12. Mapping SOA Artefacts onto an Enterprise Reference Architecture Framework

    Science.gov (United States)

    Noran, Ovidiu

    Currently, there is still no common agreement on the service-Oriented architecture (SOA) definition, or the types and meaning of the artefacts involved in the creation and maintenance of an SOA. Furthermore, the SOA image shift from an infrastructure solution to a business-wide change project may have promoted a perception that SOA is a parallel initiative, a competitor and perhaps a successor of enterprise architecture (EA). This chapter attempts to map several typical SOA artefacts onto an enterprise reference framework commonly used in EA. This is done in order to show that the EA framework can express and structure most of the SOA artefacts and therefore, a framework for SOA could in fact be derived from an EA framework with the ensuing SOA-EA integration benefits.

  13. GEARS: An Enterprise Architecture Based On Common Ground Services

    Science.gov (United States)

    Petersen, S.

    2014-12-01

    Earth observation satellites collect a broad variety of data used in applications that range from weather forecasting to climate monitoring. Within NOAA the National Environmental Satellite Data and Information Service (NESDIS) supports these applications by operating satellites in both geosynchronous and polar orbits. Traditionally NESDIS has acquired and operated its satellites as stand-alone systems with their own command and control, mission management, processing, and distribution systems. As the volume, velocity, veracity, and variety of sensor data and products produced by these systems continues to increase, NESDIS is migrating to a new concept of operation in which it will operate and sustain the ground infrastructure as an integrated Enterprise. Based on a series of common ground services, the Ground Enterprise Architecture System (GEARS) approach promises greater agility, flexibility, and efficiency at reduced cost. This talk describes the new architecture and associated development activities, and presents the results of initial efforts to improve product processing and distribution.

  14. Theoretical Perspectives of Enterprise Architecture for Technological Transformation

    DEFF Research Database (Denmark)

    Tambo, Torben

    2017-01-01

    The purpose of this article is to investigate the completeness of the theoretical foundations of Enterprise Architecture (EA) by reviewing four selected disciplines from Management of Technology (MOT). Often theory on EA is based on prior EA contributions or more distant contributions such as ser......The purpose of this article is to investigate the completeness of the theoretical foundations of Enterprise Architecture (EA) by reviewing four selected disciplines from Management of Technology (MOT). Often theory on EA is based on prior EA contributions or more distant contributions...... such as service science, semiotics, psycho-social constructs, business process analytics, and systems science. It is here argued that other theories might be more supportive to EA. The current article is based on a review of the MOT literature and a subsequent literature review within each of the four specialized...

  15. A new paradigm for continuous alignment of business and IT: combining enterprise architecture modeling and enterprise ontology

    CSIR Research Space (South Africa)

    Hinkelmann, K

    2015-08-01

    Full Text Available Alignment of Business and IT: Combining Enterprise Architecture Modeling and Enterprise Ontology Knut Hinkelmann, School of Business, FHNW University of Applied Sciences and Arts Northwestern Switzerland, 4600 Olten, Switzerland and Department... initiatives, the architecture at the start of a development might not be appropriate anymore when the new business processes and information systems are rolled out. The grand challenge for today's enterprises, which we deal with in this research...

  16. An Enterprise Information Architecture: A Case Study for Decentralized Organizations

    International Nuclear Information System (INIS)

    Watson, R.W.

    1999-01-01

    As enterprises become increasingly information based, making improvements in their information activities is a top priority to assure their continuing competitiveness. A key to achieving these improvements is developing an Enterprise Information Architecture (EIA). An EIA can be viewed as a structured set of multidimensional interrelated elements that support all information processes. The current ad hoc EIAs in place within many enterprises can not meet their future needs because of a lack of a coherent framework, incompatibilities, missing elements, few and poorly understood standards, uneven quality and unnecessary duplications. This paper discusses the EIA developed at Lawrence Livermore National Laboratory as a case study, for other information based enterprises, particularly those with decentralized and autonomous organization structures and cultures. While the architecture is important, the process by which it is developed and sustained over time is equally important. This paper outlines the motivation for an EIA and discusses each of the interacting elements identified. It also presents an organizational structure and processes for building a sustainable EIA activity

  17. Interoperability, Enterprise Architectures, and IT Governance in Government

    OpenAIRE

    Scholl , Hans ,; Kubicek , Herbert; Cimander , Ralf

    2011-01-01

    Part 4: Architecture, Security and Interoperability; International audience; Government represents a unique, and also uniquely complex, environment for interoperation of information systems as well as for integration of workflows and processes across governmental levels and branches. While private-sector organizations by and large have the capacity to implement “enterprise architectures” in a relatively straightforward fashion, for notable reasons governments do not enjoy such luxury. For thi...

  18. Developing Enterprise Architecture Skills: A Developing Country Perspective

    OpenAIRE

    Shaanika , Irja; Iyamu , Tiko

    2014-01-01

    Part 1: Key Competencies for Educating ICT Professionals; International audience; Through different approaches, organisations strive to evolve their competitiveness, as well as their addressing their operational and strategic needs. Some organisations employ Enterprise Architecture (EA), to bridge the gap between the business and IT, and to providing strategic goals. However, there exists scarcity of EA Skills in many developing countries. This could be attributed to the uniqueness of the dis...

  19. Managing Innovation and Business Development Using Enterprise Architecture

    DEFF Research Database (Denmark)

    Tambo, Torben; Bækgaard, Lars

    2011-01-01

    technologies. In management of IT, it has become increasingly popular to use Enterprise Architecture (EA) as a method and supported by a series of formal frameworks. EA maps artifacts and motives against the business strategy. In this paper, MOT and EA are reviewed for their mutual potentials and issues. Two...... of well planned technological changes. Management of technology (MOT) addresses identification, selection, (long term) planning, designing, implementation and operation of technology based business development. Information Technology (IT) is a key enabler for a vast range of contemporary corporate...... case studies illustrate how enterprises can make major changes derived from business strategy observing both MOT and EA. This suggests a combined view inspired from the IT business’ dedication to EA using EA’s formalisms and the management orientation of MOT to improve understanding technological...

  20. Information Technology: OMB Leadership Critical to Making Needed Enterprise Architecture and E-Government Progress

    National Research Council Canada - National Science Library

    2002-01-01

    .... Our best practices research of successful public and private-sector organizations has similarly identified enterprise architectures as essential to effective business and technology transformation...

  1. Integrating Environmental and Information Systems Management: An Enterprise Architecture Approach

    Science.gov (United States)

    Noran, Ovidiu

    Environmental responsibility is fast becoming an important aspect of strategic management as the reality of climate change settles in and relevant regulations are expected to tighten significantly in the near future. Many businesses react to this challenge by implementing environmental reporting and management systems. However, the environmental initiative is often not properly integrated in the overall business strategy and its information system (IS) and as a result the management does not have timely access to (appropriately aggregated) environmental information. This chapter argues for the benefit of integrating the environmental management (EM) project into the ongoing enterprise architecture (EA) initiative present in all successful companies. This is done by demonstrating how a reference architecture framework and a meta-methodology using EA artefacts can be used to co-design the EM system, the organisation and its IS in order to achieve a much needed synergy.

  2. Enterprise Architecture as a Way of Synchronizing Enterprise Resource Planning Systems and Business Processes

    DEFF Research Database (Denmark)

    Johansson, Björn; Holst, Philip; Henningsson, Stefan

    2009-01-01

    A major question for contemporary organizations is how to support business processes with ICT. One way to do so is by the adoption of a standardized software package such as enterprise resource planning (ERP) systems. However, this demands that either the system is adjusted to existing business...... processes or that the business processes are adjusted to the system’s inherited processes, often described as an alignment problem. This paper suggests that instead of alignment, organization-technology synchronization would be better, since an organization’s business processes as well as the technology...... used is continuously evolving. The question is then how synchronization could be achieved and if any tools exists that could support this. Our suggestion is that enterprise architecture (EA) could be seen as a tool to increase organizationtechnology synchronization. We investigated a role based...

  3. ENTERPRISE SERVICES ARCHITECTURE IN THE WORLD OF INFORMATION TECHNOLOGY

    Directory of Open Access Journals (Sweden)

    Stefan IOVAN

    2012-05-01

    Full Text Available Enterprise Services Architecture (ESA is blueprint for now enterprise software should be constructed to provide maximum business value. The challenge facing most companies is not whether to adopt Service-Oriented Architecture (SOA, but when and how to do so. There is always a lag between technological vision and business feasibility. It also takes time to fully realize the potential of existing technologies, a process that does not stop the moment the new thing arrives. But when the value of a new approach such as ESA starts to make a difference and produces a competitive advantage, the motivation to change skyrockets. The time to change becomes now and the hunger for learning grows. The goal of this paper is to satisfy the hunger for information for those who suspect that ESA may be a gateway to transforming Information Technology (IT into a strategic weapon. This paper will explain – in more detail that ever before – what ESA is bringing the concept to life in all of its products as a platform supported by an ecosystem.

  4. Managing changes in the enterprise architecture modelling context

    Science.gov (United States)

    Khanh Dam, Hoa; Lê, Lam-Son; Ghose, Aditya

    2016-07-01

    Enterprise architecture (EA) models the whole enterprise in various aspects regarding both business processes and information technology resources. As the organisation grows, the architecture of its systems and processes must also evolve to meet the demands of the business environment. Evolving an EA model may involve making changes to various components across different levels of the EA. As a result, an important issue before making a change to an EA model is assessing the ripple effect of the change, i.e. change impact analysis. Another critical issue is change propagation: given a set of primary changes that have been made to the EA model, what additional secondary changes are needed to maintain consistency across multiple levels of the EA. There has been however limited work on supporting the maintenance and evolution of EA models. This article proposes an EA description language, namely ChangeAwareHierarchicalEA, integrated with an evolution framework to support both change impact analysis and change propagation within an EA model. The core part of our framework is a technique for computing the impact of a change and a new method for generating interactive repair plans from Alloy consistency rules that constrain the EA model.

  5. Virtual Enterprise Reference Architecture and Methodology (VERAM), Joint D41/D43 deliverable of GLOBEMEN

    DEFF Research Database (Denmark)

    Tølle, Martin; Zwegers, Arian; Vesterager, Johan

    2003-01-01

    . IMS Globemen is an inter-regional project aiming to develop methods, tools and architectures to support inter-enterprise operations in one-of-kind industries, in different lifecycle phases. This deliverable describes an architectural framework VERAM including a description/elaboration of its elements......-of-a-kind-production”, the concept of the Virtual Enterprise (VE) and the Virtual Enterprise Reference Architecture (VERA) developed in GLOBEMEN. - In Chapter 4 a so-called life history example is presented to give a possible scenario about how an enterprise network could evolve over time, and to point out the need for preparing...... and setting up networks and VEs. The life history example in Chapter 4 highlights the potential for preparing and reusing existing knowledge related to enterprise networks and VEs. - As a means to structure relevant knowledge GLOBEMEN developed the VERAM (Virtual Enterprise Reference Architecture...

  6. Proposal of a referential Enterprise Architecture management framework for companies

    Directory of Open Access Journals (Sweden)

    César Esquetini Cáceres

    2014-12-01

    Full Text Available (Received: 2014/11/26 - Accepted: 2014/12/17Enterprise Architecture (EA is conceived nowadays as an essential management activity to visualize and evaluate the future direction of a company. The objective of this paper is to make a literature review on EA to evaluate its role as management tool. It is also explained how EA can fulfill two fundamental purposes, first as a tool for assessing the current situation (self-assessment of an organization; second as a tool to model and simulate future scenarios that allow better decision making for the restructuration and development of improvement plans. Furthermore an analysis is made of the integration possibilities of EA with other business management methodologies, as balanced score card (BSC and the model of the European Foundation for Quality Management (EFQM. As the result a management framework is presented, which includes the required elements to achieve excellence and quality standards in organizations.

  7. Development of enterprise architecture in university using TOGAF as framework

    Science.gov (United States)

    Amalia, Endang; Supriadi, Hari

    2017-06-01

    The university of XYZ is located in Bandung, West Java. It has an infrastructure of technology information (IT) which is managed independently. Currently, the IT at the University of XYZ employs a complex conventional management pattern that does not result in a fully integrated IT infrastructure. This is not adaptive in addressing solutions to changing business needs and applications. In addition, it impedes the innovative development of sustainable IT services and also contributes to an unnecessary high workload for managers. This research aims to establish the concept of IS/IT strategic planning. This is used in the development of the IS/IT and in designing the information technology infrastructure based on the framework of The Open Group Architecture Framework (TOGAF) and Architecture Development Method (ADM). A case study will be done at the University of XYZ using the concept of qualitative research through review of literatures and interviews. This study generates the following stages:(1) forming a design using TOGAF and the ADM around nine functional areas of business and propose 12 application candidates to be developed at XYZ University; (2) generating 11 principles of the development of information technology architecture; (3) creating a portfolio for future applications (McFarlan Grid), generating 6 applications in the strategic quadrant (SIAKAD-T, E-LIBRARY, SIPADU-T, DSS, SIPPM-T, KMS), 2 quadrant application operations (PMS-T, CRM), 4 quadrant application supports (MNC-T, NOPEC-T, EMAIL-SYSTEM, SSO); and (4) modelling the enterprise architecture of this study which could be a reference in making a blueprint for the development of information systems and information technology at the University of XYZ.

  8. Depiction of experimental findings for a cloud enterprise architecture

    CSIR Research Space (South Africa)

    Mvelase, PS

    2015-12-01

    Full Text Available ) model of cloud computing to enable Small, Medium and Micro Enterprises (SMMEs) to respond quickly to customers' demands and market opportunities, therefore Enabling Small, Medium, and Micro Enterprises through Cloud utility Infrastructure: gaining...

  9. A hybrid method for evaluating enterprise architecture implementation.

    Science.gov (United States)

    Nikpay, Fatemeh; Ahmad, Rodina; Yin Kia, Chiam

    2017-02-01

    Enterprise Architecture (EA) implementation evaluation provides a set of methods and practices for evaluating the EA implementation artefacts within an EA implementation project. There are insufficient practices in existing EA evaluation models in terms of considering all EA functions and processes, using structured methods in developing EA implementation, employing matured practices, and using appropriate metrics to achieve proper evaluation. The aim of this research is to develop a hybrid evaluation method that supports achieving the objectives of EA implementation. To attain this aim, the first step is to identify EA implementation evaluation practices. To this end, a Systematic Literature Review (SLR) was conducted. Second, the proposed hybrid method was developed based on the foundation and information extracted from the SLR, semi-structured interviews with EA practitioners, program theory evaluation and Information Systems (ISs) evaluation. Finally, the proposed method was validated by means of a case study and expert reviews. This research provides a suitable foundation for researchers who wish to extend and continue this research topic with further analysis and exploration, and for practitioners who would like to employ an effective and lightweight evaluation method for EA projects. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. Technology Reference Model (TRM) Reports: Federal Enterprise Architecture (FEA) Mapping Report

    Data.gov (United States)

    Department of Veterans Affairs — The One VA Enterprise Architecture (OneVA EA) is a comprehensive picture of the Department of Veterans Affairs' (VA) operations, capabilities and services and the...

  11. An Enterprise Architecture Perspective to Electronic Health Record Based Care Governance.

    Science.gov (United States)

    Motoc, Bogdan

    2017-01-01

    This paper proposes an Enterprise Architecture viewpoint of Electronic Health Record (EHR) based care governance. The improvements expected are derived from the collaboration framework and the clinical health model proposed as foundation for the concept of EHR.

  12. Technology Reference Model (TRM) Reports: Federal Enterprise Architecture (FEA) Category Count Report

    Data.gov (United States)

    Department of Veterans Affairs — The One VA Enterprise Architecture (OneVA EA) is a comprehensive picture of the Department of Veterans Affairs' (VA) operations, capabilities and services and the...

  13. Understanding Enterprise Architecture with Topic Modeling Preliminary Research Based on Journal Articles

    DEFF Research Database (Denmark)

    Nardello, Marco; Møller, Charles; Gøtze, John

    2018-01-01

    The next 3 years will be more important than the last 50 due to the digital transformation across industries. Enterprise Architecture (EA), the discipline that should lead enterprise responses to disruptive forces, is far from ready to drive the next wave of change. The state of the art in the di...

  14. Enterprise Architecture Modeling of Core Administrative Systems at KTH : A Modifiability Analysis

    OpenAIRE

    Rosell, Peter

    2012-01-01

    This project presents a case study of modifiability analysis on the Information Systems which are central to the core business processes of Royal Institution of Technology in Stockholm, Sweden by creating, updating and using models. The case study was limited to modifiability regarding only specified Information Systems. The method selected was Enterprise Architecture together with Enterprise Architecture Analysis research results and tools from the Industrial Information and Control Systems ...

  15. Inter organizational System Management for integrated service delivery: an Enterprise Architecture Perspective

    OpenAIRE

    Elmir, Abir; Elmir, Badr; Bounabat, Bouchaib

    2015-01-01

    Service sharing is a prominent operating model to support business. Many large inter-organizational networks have implemented some form of value added integrated services in order to reach efficiency and to reduce costs sustainably. Coupling Service orientation with enterprise architecture paradigm is very important at improving organizational performance through business process optimization. Indeed, enterprise architecture management is increasingly discussed because of information system r...

  16. A Method to Improve Test Process in Federal Enterprise Architecture Framework Using ISTQB Framework

    OpenAIRE

    Hamideh Mahdavifar; Ramin Nassiri; Alireza Bagheri

    2012-01-01

    Enterprise Architecture (EA) is a framework for description, coordination and alignment of all activities across the organization in order to achieve strategic goals using ICT enablers. A number of EA-compatible frameworks have been developed. We, in this paper, mainly focus on Federal Enterprise Architecture Framework (FEAF) since its reference models are plentiful. Among these models we are interested here in its business reference model (BRM). The test process is one important subject of a...

  17. Analysis of central enterprise architecture elements in models of six eHealth projects.

    Science.gov (United States)

    Virkanen, Hannu; Mykkänen, Juha

    2014-01-01

    Large-scale initiatives for eHealth services have been established in many countries on regional or national level. The use of Enterprise Architecture has been suggested as a methodology to govern and support the initiation, specification and implementation of large-scale initiatives including the governance of business changes as well as information technology. This study reports an analysis of six health IT projects in relation to Enterprise Architecture elements, focusing on central EA elements and viewpoints in different projects.

  18. Virtual enterprise architecture and methodology - Initial results from the Globeman21 project

    DEFF Research Database (Denmark)

    Vesterager, Johan; Larsen, Lars Bjørn; Gobbi, Chiara

    1999-01-01

    This paper will focus on presenting the initial results from the IMS project Globeman21 regarding generic models for Extended Enterprise Management (EEM). In particular the paper outlines a proposed architecture for the creation of virtual enterprises, industrial requirements regarding the generic...... models, terminology for describing extended enterprises, and initial considerations regarding a methodology for EEM. Globeman21 see the extended enterprise as a concept covering the totality of different concepts dealing with the expansion or extension of enterprise activities. One way of realising...... the concept of extended enterprise is through the creation of virtual enterprise, based on a more or less formalised network. This approach is the basis for the development of the generic EEM model within Globeman21....

  19. Emerging trends in the evolution of service-oriented and enterprise architectures

    CERN Document Server

    Zimmermann, Alfred; Jain, Lakhmi

    2016-01-01

    This book presents emerging trends in the evolution of service-oriented and enterprise architectures. New architectures and methods of both business and IT are integrating services to support mobility systems, Internet of Things, Ubiquitous Computing, collaborative and adaptive business processes, Big Data, and Cloud ecosystems. They inspire current and future digital strategies and create new opportunities for the digital transformation of next digital products and services. Services Oriented Architectures (SOA) and Enterprise Architectures (EA) have emerged as a useful framework for developing interoperable, large-scale systems, typically implementing various standards, like Web Services, REST, and Microservices. Managing the adaptation and evolution of such systems presents a great challenge. Service-Oriented Architecture enables flexibility through loose coupling, both between the services themselves and between the IT organizations that manage them. Enterprises evolve continuously by transforming and ext...

  20. A new method for performance evaluation of enterprise architecture using streotypes

    Directory of Open Access Journals (Sweden)

    Samaneh Khamseh

    2013-11-01

    Full Text Available These days, we see many organizations with extremely complex systems with various processes, organizational units, individuals, and information technology support where there are complex relationships among their various elements. In these organizations, poor architecture reduces efficiency and flexibility. Enterprise architecture, with full description of the functions of information technology in the organization, attempts to reduce the complexity of the most efficient tools to reach organizational objectives. Enterprise architecture can better assess the optimal conditions for achieving organizational goals. For evaluating enterprise architecture, executable model need to be applied. Executable model using a static architectural view to describe necessary documents need to be created. Therefore, to make an executable model, we need a requirement to produce products of the enterprise architecture to create an executable model. In this paper, for the production of an enterprise architecture, object-oriented approach is implemented. We present an algorithm to use stereotypes by considering reliability assessment. The approach taken in this algorithm is to improve the reliability by considering additional components in parallel and using redundancy techniques to maintain the minimum number of components. Furthermore, we implement the proposed algorithm on a case study and the results are compared with previous algorithms.

  1. Capturing Business Strategy and Value in Enterprise Architecture to Support Portfolio Valuation

    NARCIS (Netherlands)

    Iacob, Maria Eugenia; Quartel, Dick; Jonkers, H.

    2012-01-01

    This paper investigates and enhances the suitability of the Archi Mate enterprise architecture modeling language to support the modeling of business strategy concepts and architecture-based approaches to IT portfolio valuation. It gives an overview of existing strategy and valuation concepts and

  2. Using Enterprise Architecture for the Alignment of Information Systems in Supply Chain Management

    DEFF Research Database (Denmark)

    Tambo, Torben

    2010-01-01

    Using information systems in supply chain management (SCM) has become commonplace, and therefore architectural issue are part of the agenda for this domain. This article uses three perspectives on enterprise architecture (EA) in the supply chain: The "correlation view," the "remote view...

  3. A lightweight approach for designing enterprise architectures using BPMN : an application in hospitals

    NARCIS (Netherlands)

    Barros, O.; Seguel Pérez, R.E.; Quezada, A.; Dijkman, R.; Hofstetter, J.; Koehler, J.

    2011-01-01

    An Enterprise Architecture (EA) comprises different models at different levels of abstraction. Since existing EA design approaches, e.g. MDA, use UML for modeling, the design of the architecture becomes complex and time consuming. In this paper, we present an integrated and lightweight design

  4. Building a Foundation for the Implementation of an Enterprise Architecture for the Argentinian Army

    Science.gov (United States)

    2016-06-01

    architectural layers can be identified in the Argentinian Army. These layers are the strategic level, the business and operations process level, the...use of the right architecture . Successful organizations built an automated IT infrastructure and digitized processes to implement the best business ...According to the TOGAF website (The Open Group, 2016), the architecture of an enterprise is divided into four categories of types:  Business

  5. A Method for Developing Enterprise Architecture Frameworks: An Interpretive Phenomenology Study

    Directory of Open Access Journals (Sweden)

    Ali Moeini

    2015-03-01

    Full Text Available Nowadays, many of organizations, who are involved in enterprise architecting, make their own architecture framework or customize existing frameworks. These endeavors are based on the knowledge and the experience of each organization, and there is no defined method for developing the enterprise architecture framework. Therefore, a method for developing architecture framework is presented in this qualitative research. For this reason, 15 versions of 5 most used architecture frameworks are analyzed based on the interpretive phenomenology. Based on this analysis, a method for developing architecture frameworks is introduced which contains 8 disciplines and 6 phases. Analyzing the qualitative data of the research and also the validation of the research are carried out using the guidelines of Van Manen in the interpretive phenomenology.

  6. Managing the Evolution of an Enterprise Architecture using a MAS-Product-Line Approach

    Science.gov (United States)

    Pena, Joaquin; Hinchey, Michael G.; Resinas, manuel; Sterritt, Roy; Rash, James L.

    2006-01-01

    We view an evolutionary system ns being n software product line. The core architecture is the unchanging part of the system, and each version of the system may be viewed as a product from the product line. Each "product" may be described as the core architecture with sonre agent-based additions. The result is a multiagent system software product line. We describe an approach to such n Software Product Line-based approach using the MaCMAS Agent-Oriented nzethoclology. The approach scales to enterprise nrchitectures as a multiagent system is an approprinre means of representing a changing enterprise nrchitectclre nnd the inferaction between components in it.

  7. Presenting Enterprise Architecture Strategies Using Business Model Canvas (Case Study of E-commerce PT Xyz)

    OpenAIRE

    Christini, Chintamy; Rahmad, Basuki

    2015-01-01

    Information Technology (IT) is known as enabler of business. One of the study that align business and IT is enterprise architecture. In this era, one of the business that become a trend the world is electronic commerce (e-commerce). With the suitable enterprise architecture strategies, e-commerce can be improved according to the business and IT condition. This paper represents about study case of an Indonesian e-commerce website which is still unknown by internet users and the SWOT strategy a...

  8. Development of an Web Service Architecture for Enterprise Application Integration

    International Nuclear Information System (INIS)

    Kim, Ji-Hyeon; Jung, Jae-Cheon; Chang, Young-Woo; Chang, Hoon-Seon; Kim, Jae-Cheol; Kim, Hang-Bae; Kim, Kyu-Ho; Lee, Dong-Chul

    2007-01-01

    The purpose of Enterprise Application Integration (EAI) is to enable the interoperability between two or more enterprise software systems. These systems, for example, can be an Enterprise Resource Planning (ERP) system, an Enterprise Asset Management (EAM) system or a Condition Monitoring system. Traditional EAI approach, based on point-to-point connection, is expensive, vendor specific with limited modules and restricted interoperability with other ERPs and applications. To overcome these drawbacks, the Web Service based EAI has emerged. It allows the integration without point to point linking and with less costs. Many approaches of Web service based EAI are combined with ORACLE, SAP, PeopleSoft, WebSphere, SIEBEL etc. as a system integration platform. The approach still has the restriction that only predefined clients can access the services. This means clients must know exactly the protocol for calling the services and if they don't have the access information they never can get the services. This is because these Web services are based on syntactic service description. In this paper, a semantic based EAI approach, that allows the uninformed clients to access the services, is introduced. The semantic EAI is designed with the Web services that have semantic service descriptions. The Semantic Web Services(SWS) are described in Web Ontology Language for Services(OWL-S), a semantic service ontology language, and advertised in Universal Description, Discovery and Integration (UDDI). Clients find desired services through the UDDI and get services from service providers through Web Service Description Language(WSDL)

  9. Development of an Web Service Architecture for Enterprise Application Integration

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ji-Hyeon; Jung, Jae-Cheon; Chang, Young-Woo; Chang, Hoon-Seon; Kim, Jae-Cheol; Kim, Hang-Bae [Korea Power Engineering Company, Daejeon (Korea, Republic of); Kim, Kyu-Ho; Lee, Dong-Chul [Korea Electric Power Data Network, Daejeon (Korea, Republic of)

    2007-07-01

    The purpose of Enterprise Application Integration (EAI) is to enable the interoperability between two or more enterprise software systems. These systems, for example, can be an Enterprise Resource Planning (ERP) system, an Enterprise Asset Management (EAM) system or a Condition Monitoring system. Traditional EAI approach, based on point-to-point connection, is expensive, vendor specific with limited modules and restricted interoperability with other ERPs and applications. To overcome these drawbacks, the Web Service based EAI has emerged. It allows the integration without point to point linking and with less costs. Many approaches of Web service based EAI are combined with ORACLE, SAP, PeopleSoft, WebSphere, SIEBEL etc. as a system integration platform. The approach still has the restriction that only predefined clients can access the services. This means clients must know exactly the protocol for calling the services and if they don't have the access information they never can get the services. This is because these Web services are based on syntactic service description. In this paper, a semantic based EAI approach, that allows the uninformed clients to access the services, is introduced. The semantic EAI is designed with the Web services that have semantic service descriptions. The Semantic Web Services(SWS) are described in Web Ontology Language for Services(OWL-S), a semantic service ontology language, and advertised in Universal Description, Discovery and Integration (UDDI). Clients find desired services through the UDDI and get services from service providers through Web Service Description Language(WSDL)

  10. Layered distributed simulation architecture to support the C2 enterprise

    CSIR Research Space (South Africa)

    Duvenhage, A

    2009-09-01

    Full Text Available between these systems and that a capability is required to demonstrate, support and evaluate interoperability. This paper discusses the layered software architecture of a C++ software application framework for developing applications that support...

  11. A Review of Enterprise Architecture Use in Defence

    Science.gov (United States)

    2014-09-01

    dictionary of terms; • architecture description language; • architectural information (pertaining both to specific projects and higher level...UNCLASSIFIED 59 Z39.19 2005 Monolingual Controlled Vocabularies, National Information Standards Organisation, Bethesda: NISO Press, 2005. BABOK 2009...togaf/ Z39.19 2005 ANSI/NISO Z39.19 – Guidelines for the Construction, Format, and Management of Monolingual Controlled Vocabularies, Bethesda: NISO

  12. Custom-made cloud enterprise architecture for small, medium and micro enterprises

    CSIR Research Space (South Africa)

    Mvelase, P

    2011-07-01

    Full Text Available quickly to customers’ demands and market opportunities. The virtual enterprise model is based on the ability to create temporary co-operations and realize the value of a short term business opportunity that the partners cannot fully capture on their own...

  13. Laying the groundwork for enterprise-wide medical language processing services: architecture and process.

    Science.gov (United States)

    Chen, Elizabeth S; Maloney, Francine L; Shilmayster, Eugene; Goldberg, Howard S

    2009-11-14

    A systematic and standard process for capturing information within free-text clinical documents could facilitate opportunities for improving quality and safety of patient care, enhancing decision support, and advancing data warehousing across an enterprise setting. At Partners HealthCare System, the Medical Language Processing (MLP) services project was initiated to establish a component-based architectural model and processes to facilitate putting MLP functionality into production for enterprise consumption, promote sharing of components, and encourage reuse. Key objectives included exploring the use of an open-source framework called the Unstructured Information Management Architecture (UIMA) and leveraging existing MLP-related efforts, terminology, and document standards. This paper describes early experiences in defining the infrastructure and standards for extracting, encoding, and structuring clinical observations from a variety of clinical documents to serve enterprise-wide needs.

  14. A comparison of practitioner and researcher definitions of enterprise architecture using an interpretation method

    CSIR Research Space (South Africa)

    Mentz, J

    2012-10-01

    Full Text Available The term enterprise architecture has been in use for almost thirty years if the seminal paper (published in 1987) by Zachman is taken as its starting point. As a scientific area of study this time span is relatively short but for the practitioner...

  15. Understanding the Value of Enterprise Architecture for Organizations: A Grounded Theory Approach

    Science.gov (United States)

    Nassiff, Edwin

    2012-01-01

    There is a high rate of information system implementation failures attributed to the lack of alignment between business and information technology strategy. Although enterprise architecture (EA) is a means to correct alignment problems and executives highly rate the importance of EA, it is still not used in most organizations today. Current…

  16. MENDEFINISIKAN ENTERPRISE ARCHITECTURE PLANNING DALAM PERENCANAAN INTEGRASI SISTEM INFORMASI PERPUSTAKAN SEKOLAH

    Directory of Open Access Journals (Sweden)

    Agung Baitul Hikmah

    2016-03-01

    Full Text Available Abstract - A school library is a place which serves many things for student and academic civitas needing. The Existence of school library is something important in the school environment to fulfill all of needs and interests which can be got from the the library, so the concept of library needs a new concept which can give more benefits from its existence. The concept of enterprise Architecture Planning is able to arrange a layout to realize a new concept for existencing a library,such as The information system integration for a library. In this Research.the researcher makes enterprise architecture to integrate the information system of school library such as : in SMUN 1 Tasikmalaya, SMU SIliwangi Tasikmalaya,SMK MJPS Tasikmalaya, SMK Bina Lestari PUI Tasikmalaya. Based on the business process which is run by every library, EAP can show a blueprint for the architecture of integration library information system which involves business architecture, application architecture, information architecture and technology architecture. Keyword: Enterprise, Arsitektur Enterprise, Integration Library Information System, SIPT. Abstrak - Perpustakaan sekolah adalah tempat yang menyajikan banyak hal untuk mahasiswa dan membutuhkan civitas akademik. Keberadaan perpustakaan sekolah adalah sesuatu yang penting dalam lingkungan sekolah memenuhi semua kebutuhan dan kepentingan yang dapat dapatkan dari Perpustakaan, sehingga konsep Perpustakaan kebutuhan sebuah konsep baru yang dapat memberikan manfaat lebih dari keberadaannya. Konsep arsitektur perencanaan perusahaan ini mampu mengatur sebuah layout untuk mewujudkan sebuah konsep baru untuk existencing sebuah perpustakaan, seperti informasi sistem integrasi untuk Perpustakaan. Dalam penelitian ini, peneliti membuat arsitektur perusahaan untuk mengintegrasikan sistem informasi perpustakaan sekolah seperti: di SMUN 1 Tasikmalaya SMU Siliwangi Tasikmalaya, SMK MJPS Tasikmalaya, SMK Bina Lestari PUI Tasikmalaya

  17. Security Aspects of an Enterprise-Wide Network Architecture.

    Science.gov (United States)

    Loew, Robert; Stengel, Ingo; Bleimann, Udo; McDonald, Aidan

    1999-01-01

    Presents an overview of two projects that concern local area networks and the common point between networks as they relate to network security. Discusses security architectures based on firewall components, packet filters, application gateways, security-management components, an intranet solution, user registration by Web form, and requests for…

  18. Reshaping the Enterprise through an Information Architecture and Process Reengineering.

    Science.gov (United States)

    Laudato, Nicholas C.; DeSantis, Dennis J.

    1995-01-01

    The approach used by the University of Pittsburgh (Pennsylvania) in designing a campus-wide information architecture and a framework for reengineering the business process included building consensus on a general philosophy for information systems, using pattern-based abstraction techniques, applying data modeling and application prototyping, and…

  19. Proposing an Optimal Learning Architecture for the Digital Enterprise.

    Science.gov (United States)

    O'Driscoll, Tony

    2003-01-01

    Discusses the strategic role of learning in information age organizations; analyzes parallels between the application of technology to business and the application of technology to learning; and proposes a learning architecture that aligns with the knowledge-based view of the firm and optimizes the application of technology to achieve proficiency…

  20. Performance evaluation of enterprise architecture with a formal fuzzy model (FPN

    Directory of Open Access Journals (Sweden)

    Ashkan Marahel

    2012-10-01

    Full Text Available Preparing enterprise architecture is complicated procedure, which uses framework as structure regularity and style as the behavior director for controlling complexity. As in architecture behavior, precedence over structure, for better diagnosis of a behavior than other behaviors, there is a need to evaluate the architecture performance. Enterprise architecture cannot be organized without the benefit of the logical structure. Framework provides a logical structure for classifying architectural output. Among the common architectural framework, the C4ISR is one of the most appropriate frameworks because of the methodology of its production and the level of aggregation capability and minor revisions. C4ISR framework, in three views and by using some documents called product, describes the architecture. In this paper, for developing the systems, there are always uncertainties in information systems and we may use new version of UML called FUZZY-UML, which includes structure and behavior of the system. The proposed model of this paper also uses Fuzzy Petri nets to analyze the developed system.

  1. PERANCANGAN ARSITEKTUR SISTEM INFORMASI MENGGUNAKAN METODE ENTERPRISE ARCHITECTURE PLANNING (Studi Kasus : Universitas Purwakarta - Purwakarta

    Directory of Open Access Journals (Sweden)

    Beki Subaeki

    2016-03-01

    Full Text Available ABSTRAK Pemanfaatan teknologi informasi pada suatu organisasi sangat diperlukan, hal ini diperlukan terlebih oleh organisasi besar semacam perguruan tinggi kerena pengembangan sistem informasi akan semakin komplek dan akan berpengaruh pada perkembangan bisnis yang sedang berjalan. Pada prakteknya tidak sedikit pembangunan / pengembangan sistem informasi mengalami kegagalan, hal ini dikarenakan karena tidak sesuai dengan arah tujuan serta kebutuhan akademik. Salah satu metode yang digunakan untuk membangun/mengenbangkan sistem informasi adalah Enterprise Architecture Planning, dimana metode ini merupakan metode yang digunakan untuk pendekatan perencanaan kualitas data dengan melihat pada kebutuhan bisnis dari organisasi. Didalam Enterprise Architecture Planning akan diuraikan tentang arsitektur data, aplikasi, teknologi serta roadmap rencana implementasi dari arsitektur tersebut.Universitas Purwakarta sebagai salah satu penyelenggara pendidikan, tidak luput dari kebutuhan mendefinisikan kebutuhan bisnis dan arsitektur informasinya agar arah strategi kebijakan pengembangan organisasi dapat terencanakan dengan baik. Pemodelan arsitektur informasi pada Universitas Purwakarta, meliputi pendefinisian arsitektur data, arsitektur aplikasi, arsitektur teknologi, dan pembuatan pemetaan atau roadmap rencana implementasi. Proses dalam pendefinisian arsitektur informasi yang ditinjau, mengacu kepada proses yang sudah umum terjadi dalam bisnis penyelenggaraan sistem pendidikan khususnya di Universitas Purwakarta, sedangkan ruang lingkup pembahasan melingkupi bidang akademik, bidang administrasi keuangan. Hasil dari penelitian ini akan menghasilkan roadmap rencana implementasi yang dapat dijadikan acuan dalam pembangunan aplikasi yang mendukung fungsi bisnis organisasi.. Kata Kunci : Enterprise Architecture Planning, Arsitektur Data, Arsitektur Aplikasi Dan Arsitektur Teknologi, Sistem Informasi. ABSTRACT Utilization of information technology in an

  2. Linking Humans to Data: Designing an Enterprise Architecture for EarthCube

    Science.gov (United States)

    Xu, C.; Yang, C.; Meyer, C. B.

    2013-12-01

    National Science Foundation (NSF)'s EarthCube is a strategic initiative towards a grand enterprise that holistically incorporates different geoscience research domains. The EarthCube as envisioned by NSF is a community-guided cyberinfrastructure (NSF 2011). The design of EarthCube enterprise architecture (EA) offers a vision to harmonize processes between the operations of EarthCube and its information technology foundation, the geospatial cyberinfrastructure. (Yang et al. 2010). We envision these processes as linking humans to data. We report here on fundamental ideas that would ultimately materialize as a conceptual design of EarthCube EA. EarthCube can be viewed as a meta-science that seeks to advance knowledge of the Earth through cross-disciplinary connections made using conventional domain-based earth science research. In order to build capacity that enables crossing disciplinary chasms, a key step would be to identify the cornerstones of the envisioned enterprise architecture. Human and data inputs are the two key factors to the success of EarthCube (NSF 2011), based upon which three hypotheses have been made: 1) cross disciplinary collaboration has to be achieved through data sharing; 2) disciplinary differences need to be articulated and captured in both computer and human understandable formats; 3) human intervention is crucial for crossing the disciplinary chasms. We have selected the Federal Enterprise Architecture Framework (FEAF, CIO Council 2013) as the baseline for the envisioned EarthCube EA, noting that the FEAF's deficiencies can be improved upon with inputs from three other popular EA frameworks. This presentation reports the latest on the conceptual design of an enterprise architecture in support of EarthCube.

  3. Pemodelan Enterprise Architecture Sistem Informasi Akademik SMA PL Don Bosko Semarang Dengan Framework Zachman

    Directory of Open Access Journals (Sweden)

    Maria Alfonsa Chintia Dea Prananingrum

    2017-05-01

    Full Text Available Abstrak SMA PL Don Bosko Semarang belum dapat memanfaatkan teknologi komputer secara optimal karena masih menggunakan cara manual dalam pengelolaan berbagai macam data akademik sehingga memberikan masalah seperti lambatnya dalam pembuatan laporan yang menyulitkan kepala sekolah dalam pengambilan keputusan. Oleh sebab itu, SMA PL Don Bosko Semarang membutuhkan Sistem Informasi Akademik untuk memberikan kemudahan dalam mengelola berbagai macam data akademik secara terintegrasi serta memberikan layanan yang lebih baik kepada siswanya. Sebuah model architecture enterprise Sistem Informasi Akademik dibutuhkan agar meminimalisir kegagalan ketika menerapkan sistem tersebut sekaligus dapat berjalan sesuai kebutuhan di SMA PL Don Bosko Semarang. Metode analisis dalam penelitian ini menggunakan Framework Zachman yang memberikan pondasi dalam membantu menyediakan struktur dasar organisasi sehingga dapat mendukung perancangan dan pengembangan sistem informasi suatu organisasi. Hasil dari penelitian ini berupa blueprint (cetak biru pemodelan Sistem Informasi Akademik. Kata kunci— sistem informasi akademik, architecture enterprise, framework zachman, bluprint

  4. A Critical Realist Perspective of Enterprise Architecture Evolution: Conditioning and Outcomes

    Directory of Open Access Journals (Sweden)

    Ayed Alwadain

    2014-11-01

    Full Text Available This paper investigates how Enterprise Architecture (EA evolves due to emerging trends. It specifically explores how EA integrates the Service-oriented Architecture (SOA. Archer’s Morphogenetic theory is used as an analytical approach to distinguish the architectural conditions under which SOA is introduced, to study the relationships between these conditions and SOA introduction, and to reflect on EA evolution (elaborations that then take place. The paper focuses on reasons for why EA evolution could take place, or not and what architectural changes could happen due to SOA integration. The research builds on sound theoretical foundations to discuss EA evolution in a field that often lacks a solid theoretical groundwork. Specifically, it proposes that critical realism, using the morphogenetic theory, can provide a useful theoretical foundation to study enterprise architecture (EA evolution. The initial results of a literature review (a-priori model were extended using explorative interviews. The findings of this study are threefold. First, there are five different levels of EA-SOA integration outcomes. Second, a mature EA, flexible and well-defined EA framework and comprehensive objectives of EA improve the integration outcomes. Third, the analytical separation using Archer’s theory is helpful in order to understand how these different integration outcomes are generated.

  5. E-health and healthcare enterprise information system leveraging service-oriented architecture.

    Science.gov (United States)

    Hsieh, Sung-Huai; Hsieh, Sheau-Ling; Cheng, Po-Hsun; Lai, Feipei

    2012-04-01

    To present the successful experiences of an integrated, collaborative, distributed, large-scale enterprise healthcare information system over a wired and wireless infrastructure in National Taiwan University Hospital (NTUH). In order to smoothly and sequentially transfer from the complex relations among the old (legacy) systems to the new-generation enterprise healthcare information system, we adopted the multitier framework based on service-oriented architecture to integrate the heterogeneous systems as well as to interoperate among many other components and multiple databases. We also present mechanisms of a logical layer reusability approach and data (message) exchange flow via Health Level 7 (HL7) middleware, DICOM standard, and the Integrating the Healthcare Enterprise workflow. The architecture and protocols of the NTUH enterprise healthcare information system, especially in the Inpatient Information System (IIS), are discussed in detail. The NTUH Inpatient Healthcare Information System is designed and deployed on service-oriented architecture middleware frameworks. The mechanisms of integration as well as interoperability among the components and the multiple databases apply the HL7 standards for data exchanges, which are embedded in XML formats, and Microsoft .NET Web services to integrate heterogeneous platforms. The preliminary performance of the current operation IIS is evaluated and analyzed to verify the efficiency and effectiveness of the designed architecture; it shows reliability and robustness in the highly demanding traffic environment of NTUH. The newly developed NTUH IIS provides an open and flexible environment not only to share medical information easily among other branch hospitals, but also to reduce the cost of maintenance. The HL7 message standard is widely adopted to cover all data exchanges in the system. All services are independent modules that enable the system to be deployed and configured to the highest degree of flexibility

  6. How Cisco Systems Used Enterprise Architecture Capability to Sustain Acquisition-Based Growth

    DEFF Research Database (Denmark)

    Toppenberg, Gustav; Shanks, Graeme; Henningsson, Stefan

    2015-01-01

    Value-creating acquisitions are a major challenge for many firms. The case of Cisco Systems shows that an advanced enterprise architecture (EA) capability can contribute to the four phases of the acquisition process: pre-acquisition preparation, acquisition selection, acquisition integration...... and post-integration management. Cisco’s EA capability improves its ability to rapidly capture value from acquisitions and to sustain its acquisition-based growth strategy over time....

  7. Modeling resources and capabilities in enterprise architecture: A well-founded ontology-based proposal for ArchiMate

    NARCIS (Netherlands)

    Azevedo, Carlos; Azevedo, Carlos L.B.; Iacob, Maria Eugenia; Andrade Almeida, João; van Sinderen, Marten J.; Ferreira Pires, Luis; Guizzardi, Giancarlo

    2015-01-01

    The importance of capabilities and resources for portfolio management and business strategy has been recognized in the management literature. Despite that, little attention has been given to integrate the notions of capabilities and resources in enterprise architecture descriptions. One notable

  8. An investigation into the perceptions of business stakeholders on the benefits of enterprise architecture: the case of Telkom SA

    CSIR Research Space (South Africa)

    Lehong, SM

    2013-06-01

    Full Text Available This study identifies the perceived benefits of Enterprise Architecture (EA) among business stakeholders who are aware of EA but are not specialists in the field of ICT, and proposes a clearly differentiated and comprehensive cluster of stakeholder...

  9. ENTERPRISE ARCHITECTURE: AN INTERFACE CONCEPT BETWEEN THE ECONOMICS AND THE MANAGEMENT OF THE FIRM

    Directory of Open Access Journals (Sweden)

    José Carlos Cavalcanti

    2010-01-01

    Full Text Available This paper aims to broadly discuss a subject that intends to be an interface between the economics and the management of the firm: the Enterprise Architecture. This concept is viewed here as the most appropriate means to understand the impact of the information content, of the information systems, and of the information and communication technologies- ICTs on the internal technological and organizational choices of the firm. In support to this argument it relies on three main steps. Initially, a brief review of the main theories (economic and management of the firm is made highlighting their contributions, caveats and convergences. Then the paper bases its analysis on the concept of the firm as an “engine of information” and on a concept from the Computing Science and Engineering, Enterprise Architecture, to point out that these concepts bring up important contributions towards a more consistent interpretation of what the firm is (or how it is organized currently, in which is practically impossible to exist without the modern information tools. Finally, it is presented an innovative methodology, in an analogy to the Structure-Conduct-Performance Paradigm (that is traditionally used on the empirical market analysis, which identifies the firm according to three linear connected approaches: its architecture, its governance, and its growth strategy.

  10. ENTERPRISE ARCHITECTURE: AN INTERFACE CONCEPT BETWEEN THE ECONOMICS AND THE MANAGEMENT OF THE FIRM

    Directory of Open Access Journals (Sweden)

    José Carlos Cavalcanti

    2009-12-01

    Full Text Available This paper aims to broadly discuss a subject that intends to be an interface between the economics and the management of the firm: the Enterprise Architecture. This concept is viewed here as the most appropriate means to understand the impact of the information content, of the information systems, and of the information and communication technologies- ICTs on the internal technological and organizational choices of the firm. In support to this argument it relies on three main steps. Initially, a brief review of the main theories (economic and management of the firm is made highlighting their contributions, caveats and convergences. Then the paper bases its analysis on the concept of the firm as an “engine of information” and on a concept from the Computing Science and Engineering, Enterprise Architecture, to point out that these concepts bring up important contributions towards a more consistent interpretation of what the firm is (or how it is organized currently, in which is practically impossible to exist without the modern information tools. Finally, it is presented an innovative methodology, in an analogy to the Structure-Conduct-Performance Paradigm (that is traditionally used on the empirical market analysis, which identifies the firm according to three linear connected approaches: its architecture, its governance, and its growth strategy.

  11. Evaluation of the BPMN According to the Requirements of the Enterprise Architecture Methodology

    Directory of Open Access Journals (Sweden)

    Václav Řepa

    2012-04-01

    Full Text Available This article evaluates some characteristics of the Business Process Modelling Notation from the perspective of the business system modelling methodology. Firstly the enterprise architecture context of the business process management as well as the importance of standards are discussed. Then the Business System Modelling Methodology is introduced with special attention paid to the Business Process Meta-model as a basis for the evaluation of the BPMN features. Particular basic concepts from the Business Process Meta-model are mapped to the usable constructs of the BPMN and related issues are analysed. Finally the basic conclusions are made and the general context is discussed.

  12. Using enterprise architecture to analyse how organisational structure impact motivation and learning

    Science.gov (United States)

    Närman, Pia; Johnson, Pontus; Gingnell, Liv

    2016-06-01

    When technology, environment, or strategies change, organisations need to adjust their structures accordingly. These structural changes do not always enhance the organisational performance as intended partly because organisational developers do not understand the consequences of structural changes in performance. This article presents a model-based analysis framework for quantitative analysis of the effect of organisational structure on organisation performance in terms of employee motivation and learning. The model is based on Mintzberg's work on organisational structure. The quantitative analysis is formalised using the Object Constraint Language (OCL) and the Unified Modelling Language (UML) and implemented in an enterprise architecture tool.

  13. Dilemmas in Enterprise Architecture Research and Practice from a Perspective of Feral Information Systems

    DEFF Research Database (Denmark)

    Tambo, Torben; Bækgaard, Lars

    2013-01-01

    This paper is presenting a discussion of feral information systems (FIS) in relationship to enterprise architecture (EA) thereby aiming to better qualify the architectural understanding of information systems not in line with corporate IT/IS strategy and policies. A qualitative and case...... processes to embrace unofficial, user-driven systems. As FIS tend not to follow any rules of corporate IS, EA embrace of FIS is more complex. Using a meta-model for the social and operational character of FIS this complexity can be managed along with the improve business insight. The recognition of FIS....... This paper is opening a discussion on EA practice when centralized control is assumed to decline. EA has a tendency to be developed “top-down” emphasizing strategic alignment. In this contributed it is suggested to include social and operational alignment in EA practice....

  14. Arquitectura empresarial: una visión general Enterprise architecture: a general scope

    Directory of Open Access Journals (Sweden)

    Martín Darío Arango Serna

    2010-01-01

    Full Text Available Actualmente las empresas son más complejas y requieren procesos de negocio flexibles que sean soportados efectivamente en toda la empresa por sistemas de tecnologías de la información (TI. La implantación de una arquitectura empresarial parte del establecimiento de un conjunto de directrices arquitectónicas que permitan asegurar un desarrollo armónico entre los modelos y necesidades de la empresa, con los procesos de negocio y las tecnologías de información. Este conjunto de directrices estratégicas de TI debe partir de la misión de la empresa y del reconocimiento de las estrategias y actividades de negocio que soportan dicha misión, y derivan en la información necesaria para la operación de la organización, las tecnologías requeridas para soportar la operación y los procesos para implementar nuevas tecnologías como respuesta a los cambios y necesidades de la empresa, en la medida en que las prioridades cambian. En este artículo se hace referencia a los orígenes del concepto de arquitectura empresarial, a los dominios de arquitectura que representan las vistas del negocio y a los beneficios que representa la arquitectura empresarial para una organización.Currenlty, companies are more complex and require flexible business processes, which are actually supported by IT systems. The introduction of an enterprise architecture starts on the establishment of a set of architectural guidelines, which henceforth ensure a harmonious development between models and business needs, with business processes and information technologies. This set of strategic directions of IT, should be based on the company's mission and the recognition of the strategies and business activities which support this mission and result in the necessary information for the operation of the organization, technologies required to support the operation, and processes to implement new technologies in response to changes and needs of the company, to the extent

  15. Workflow-enabled distributed component-based information architecture for digital medical imaging enterprises.

    Science.gov (United States)

    Wong, Stephen T C; Tjandra, Donny; Wang, Huili; Shen, Weimin

    2003-09-01

    Few information systems today offer a flexible means to define and manage the automated part of radiology processes, which provide clinical imaging services for the entire healthcare organization. Even fewer of them provide a coherent architecture that can easily cope with heterogeneity and inevitable local adaptation of applications and can integrate clinical and administrative information to aid better clinical, operational, and business decisions. We describe an innovative enterprise architecture of image information management systems to fill the needs. Such a system is based on the interplay of production workflow management, distributed object computing, Java and Web techniques, and in-depth domain knowledge in radiology operations. Our design adapts the approach of "4+1" architectural view. In this new architecture, PACS and RIS become one while the user interaction can be automated by customized workflow process. Clinical service applications are implemented as active components. They can be reasonably substituted by applications of local adaptations and can be multiplied for fault tolerance and load balancing. Furthermore, the workflow-enabled digital radiology system would provide powerful query and statistical functions for managing resources and improving productivity. This paper will potentially lead to a new direction of image information management. We illustrate the innovative design with examples taken from an implemented system.

  16. Enterprise-wide PACS: beyond radiology, an architecture to manage all medical images.

    Science.gov (United States)

    Bandon, David; Lovis, Christian; Geissbühler, Antoine; Vallée, Jean-Paul

    2005-08-01

    Picture archiving and communication systems (PACS) have the vocation to manage all medical images acquired within the hospital. To address the various situations encountered in the imaging specialties, the traditional architecture used for the radiology department has to evolve. We present our preliminarily results toward an enterprise-wide PACS intended to support all kind of image production in medicine, from biomolecular images to whole-body pictures. Our solution is based on an existing radiologic PACS system from which images are distributed through an electronic patient record to all care facilities. This platform is enriched with a flexible integration framework supporting digital image communication in medicine (DICOM) and DICOM-XML formats. In addition, a generic workflow engine highly customizable is used to drive work processes. Echocardiology; hematology; ear, nose, and throat; and dermatology, including wounds, follow-up is the first implemented extensions outside of radiology. We also propose a global strategy for further developments based on three possible architectures for an enterprise-wide PACS.

  17. Using Enterprise Architecture for Analysis of a Complex Adaptive Organization's Risk Inducing Characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Salguero, Laura Marie [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Huff, Johnathon [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Matta, Anthony R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Collins, Sue S. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-08-01

    Sandia National Laboratories is an organization with a wide range of research and development activities that include nuclear, explosives, and chemical hazards. In addition, Sandia has over 2000 labs and over 40 major test facilities, such as the Thermal Test Complex, the Lightning Test Facility, and the Rocket Sled Track. In order to support safe operations, Sandia has a diverse Environment, Safety, and Health (ES&H) organization that provides expertise to support engineers and scientists in performing work safely. With such a diverse organization to support, the ES&H program continuously seeks opportunities to improve the services provided for Sandia by using various methods as part of their risk management strategy. One of the methods being investigated is using enterprise architecture analysis to mitigate risk inducing characteristics such as normalization of deviance, organizational drift, and problems in information flow. This paper is a case study for how a Department of Defense Architecture Framework (DoDAF) model of the ES&H enterprise, including information technology applications, can be analyzed to understand the level of risk associated with the risk inducing characteristics discussed above. While the analysis is not complete, we provide proposed analysis methods that will be used for future research as the project progresses.

  18. Implementation of a metadata architecture and knowledge collection to support semantic interoperability in an enterprise data warehouse.

    Science.gov (United States)

    Dhaval, Rakesh; Borlawsky, Tara; Ostrander, Michael; Santangelo, Jennifer; Kamal, Jyoti; Payne, Philip R O

    2008-11-06

    In order to enhance interoperability between enterprise systems, and improve data validity and reliability throughout The Ohio State University Medical Center (OSUMC), we have initiated the development of an ontology-anchored metadata architecture and knowledge collection for our enterprise data warehouse. The metadata and corresponding semantic relationships stored in the OSUMC knowledge collection are intended to promote consistency and interoperability across the heterogeneous clinical, research, business and education information managed within the data warehouse.

  19. EVALUATING AND REFINING THE ‘ENTERPRISE ARCHITECTURE AS STRATEGY’ APPROACH AND ARTEFACTS

    Directory of Open Access Journals (Sweden)

    M. De Vries

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: Enterprise Architecture (EA is a new discipline that has emerged from the need to create a holistic view of an enterprise, and thereby to discover business/IT integration and alignment opportunities across enterprise structures. Previous EA value propositions that merely focus on IT cost reductions will no longer convince management to invest in EA. Today, EA should enable business strategy in the organisation to create value. This resides in the ability to do enterprise optimisation through process standardisation and integration. In order to do this, a new approach is required to integrate EA into the strategy planning process of the organisation.
    This article explores the use of three key artefacts – operating models, core diagrams, and an operating maturity assessment as defined by Ross, Weill & Robertson [1] – as the basis of this new approach. Action research is applied to a research group to obtain qualitative feedback on the practicality of the artefacts.

    AFRIKAANSE OPSOMMING: Ondernemingsargitektuur (OA is ’n nuwe dissipline wat ontstaan het uit die behoefte om ’n holistiese perspektief van ’n onderneming te skep om sodoende besigheid/IT-integrasie en - belyningsgeleenthede regoor ondernemingstrukture te ontdek. Vorige OA waardeaanbiedings wat hoofsaaklik gefokus het op IT kostebesparings sal bestuur nie meer kan oorreed om in OA te belê nie. Vandag behoort OA bevoegdheid te gee aan ondernemingstrategie om werklik waarde te skep. Hierdie bevoegdheid lê gesetel in ondernemingsoptimering deur middel van prosesstandaardisasie en -integrasie. ’n Nuwe benadering word benodig ten einde OA te integreer met die strategiese beplanningsproses van die organisasie.
    Hierdie artikel ondersoek die gebruik van drie artefakte – operasionele modelle, kerndiagramme, en operasionele volwassenheidsassessering soos gedefinieer deur Ross, Weill & Robertson [1] – as die basis van hierdie nuwe benadering

  20. DEVELOPMENT OF INFORMATION SYSTEM STRATEGIES AND INFORMATION TECHNOLOGY AT PRIVATE UNIVERSITIES IN PRINGSEWU BY USING METHODOLOGY ENTERPRISE ARCHITECTURE PLANNING (EAP

    Directory of Open Access Journals (Sweden)

    Ahmad Khumaidi

    2017-08-01

    Full Text Available The development of information systems and information technology requires planning to complement the direction of the college strategy. Planning is constructed by defining data, application and technology architectures in the use of information to support business processes and then architectural design to identify needs and create architectural schemes and make plans for their implementation. Enterprise Architecture Planning (EAP is a method of data quality planning approach oriented to business needs and how the implementation of the architecture is done in such a way in an effort to support business turnover and achievement of Vision and Mission and the goal of strategic development of SI and IT at college private high. The result of this research is to get the blueprint resulting from Enterprise Architecture Planning (EAP methodology which will be used as a guide for making blueprint in the form of data architecture, application architecture and technology architecture in strategy development Information system and information technology as a whole on High private sector especially in Pringsewu

  1. Leveraging the Zachman framework implementation using action - research methodology - a case study: aligning the enterprise architecture and the business goals

    Science.gov (United States)

    Nogueira, Juan Manuel; Romero, David; Espadas, Javier; Molina, Arturo

    2013-02-01

    With the emergence of new enterprise models, such as technology-based enterprises, and the large quantity of information generated through technological advances, the Zachman framework continues to represent a modelling tool of great utility and value to construct an enterprise architecture (EA) that can integrate and align the IT infrastructure and business goals. Nevertheless, implementing an EA requires an important effort within an enterprise. Small technology-based enterprises and start-ups can take advantage of EAs and frameworks but, because these enterprises have limited resources to allocate for this task, an enterprise framework implementation is not feasible in most cases. This article proposes a new methodology based on action-research for the implementation of the business, system and technology models of the Zachman framework to assist and facilitate its implementation. Following the explanation of cycles of the proposed methodology, a case study is presented to illustrate the results of implementing the Zachman framework in a technology-based enterprise: PyME CREATIVA, using action-research approach.

  2. The Country-specific Organizational and Information Architecture of ERP Systems at Globalised Enterprises

    Directory of Open Access Journals (Sweden)

    Bálint Molnár

    2011-01-01

    Full Text Available The competition on the market forces companies to adapt to the changing environment. Most recently, the economic and financial crisis has been accelerating the alteration of both business and IT models of enterprises. The forces of globalization and internationalization motivate the restructuring of business processes and consequently IT processes. To depict the changes in a unified framework, we need the concept of Enterprise Architecture as a theoretical approach that deals with various tiers, aspects and views of business processes and different layers of application, software and hardware systems. The paper outlines a wide-range theoretical background for analyzing the re-engineering and re-organization of ERP systems at international or transnational companies in the middle-sized EU member states. The research carried out up to now has unravelled the typical structural changes, the models for internal business networks and their modification that reflect the centralization, decentralization and hybrid approaches. Based on the results obtained recently, a future research program has been drawn up to deepen our understanding of the trends within the world of ERP systems.

  3. Governance of extended lifecycle in large-scale eHealth initiatives: analyzing variability of enterprise architecture elements.

    Science.gov (United States)

    Mykkänen, Juha; Virkanen, Hannu; Tuomainen, Mika

    2013-01-01

    The governance of large eHealth initiatives requires traceability of many requirements and design decisions. We provide a model which we use to conceptually analyze variability of several enterprise architecture (EA) elements throughout the extended lifecycle of development goals using interrelated projects related to the national ePrescription in Finland.

  4. A Study on Home Based Enterprises in Kampoeng Pandean as Supporting Sustainable Architecture

    Directory of Open Access Journals (Sweden)

    Safeyah Muchlisiniyati

    2016-01-01

    Full Text Available Home Based Enterprises (HBEs provide an enormous impact on the lives of the citizens and the environment. The impacts include: increase income and welfare of the family, provide job opportunities, improve the quality of homes and the environment, and ensure life sustainability. The existence of the business leads changes to the house. Those changes that made to the house are often ignore the comfort of home space and the environment as living space. This study aims to look at the development of HBEs performed by community in Kampoeng Pandean. The measurement items used are architectural sustainability factors, ie economical sustainability, social sustainability, and enviromental sustainability. The study is located in Kampoeng Pandean Sidoarjo. The method used is a combination of qualitative and quantitative method. The results show that HBEs in Kampoeng Pandean have not fully supported the sustainable architecture. Environmental sustainability has not been met, due to the density of the environment, the high percentage of building area to land area, and the construction of business space does not consider the comfort factor.

  5. Integrating emerging earth science technologies into disaster risk management: an enterprise architecture approach

    Science.gov (United States)

    Evans, J. D.; Hao, W.; Chettri, S. R.

    2014-12-01

    Disaster risk management has grown to rely on earth observations, multi-source data analysis, numerical modeling, and interagency information sharing. The practice and outcomes of disaster risk management will likely undergo further change as several emerging earth science technologies come of age: mobile devices; location-based services; ubiquitous sensors; drones; small satellites; satellite direct readout; Big Data analytics; cloud computing; Web services for predictive modeling, semantic reconciliation, and collaboration; and many others. Integrating these new technologies well requires developing and adapting them to meet current needs; but also rethinking current practice to draw on new capabilities to reach additional objectives. This requires a holistic view of the disaster risk management enterprise and of the analytical or operational capabilities afforded by these technologies. One helpful tool for this assessment, the GEOSS Architecture for the Use of Remote Sensing Products in Disaster Management and Risk Assessment (Evans & Moe, 2013), considers all phases of the disaster risk management lifecycle for a comprehensive set of natural hazard types, and outlines common clusters of activities and their use of information and computation resources. We are using these architectural views, together with insights from current practice, to highlight effective, interrelated roles for emerging earth science technologies in disaster risk management. These roles may be helpful in creating roadmaps for research and development investment at national and international levels.

  6. Enterprise Architecture Planning in developing A planning Information System: a Case Study of Semarang State University

    Directory of Open Access Journals (Sweden)

    Budiman Kholiq

    2018-01-01

    Full Text Available This research has applied an integrated design and development of planning information system, which is been designed using Enterprise Architecture Planning. Frequent discrepancy between planning and realization of the budget that has been made, resulted in ineffective planning, is one of the reason for doing this research. The design using EAP aims to keep development aligned and in line with the strategic direction of the organization. In the practice, EAP is carried out in several stages of the planning initiation, identification and definition of business functions, proceeded with architectural design and EA implementation plan that has been built. In addition to the design of the Enterprise Architecture, this research carried out the implementation, and was tested by several methods of black box and white box. Black box testing method is used to test the fundamental aspects of the software, tested by two kinds of testing, first is using User Acceptance Testing and the second is using software functionality testing. White box testing method is used to test the effectiveness of the code in the software, tested using unit testing. Tests conducted using white box and black box on the integrated planning information system, is declared successful. Success in the software testing can not be ascertained if the software built has not shown any distinction from prior circumstance to the development of this integrated planning information system. For ensuring the success of this system implementation, the authors test consistency between the planning of data and the realization of prior-use of the information system, until after-use information system. This consistency test is done by reducing the time data of the planning and realization time. From the tabulated data, the planning information system that has been built reduces the difference between the planning time and the realization time, in which indicates that the planning information system

  7. Enterprise Architecture Planning in developing A planning Information System: a Case Study of Semarang State University

    Science.gov (United States)

    Budiman, Kholiq; Prahasto, Toni; Kusumawardhani, Amie

    2018-02-01

    This research has applied an integrated design and development of planning information system, which is been designed using Enterprise Architecture Planning. Frequent discrepancy between planning and realization of the budget that has been made, resulted in ineffective planning, is one of the reason for doing this research. The design using EAP aims to keep development aligned and in line with the strategic direction of the organization. In the practice, EAP is carried out in several stages of the planning initiation, identification and definition of business functions, proceeded with architectural design and EA implementation plan that has been built. In addition to the design of the Enterprise Architecture, this research carried out the implementation, and was tested by several methods of black box and white box. Black box testing method is used to test the fundamental aspects of the software, tested by two kinds of testing, first is using User Acceptance Testing and the second is using software functionality testing. White box testing method is used to test the effectiveness of the code in the software, tested using unit testing. Tests conducted using white box and black box on the integrated planning information system, is declared successful. Success in the software testing can not be ascertained if the software built has not shown any distinction from prior circumstance to the development of this integrated planning information system. For ensuring the success of this system implementation, the authors test consistency between the planning of data and the realization of prior-use of the information system, until after-use information system. This consistency test is done by reducing the time data of the planning and realization time. From the tabulated data, the planning information system that has been built reduces the difference between the planning time and the realization time, in which indicates that the planning information system can motivate the

  8. Modular design, application architecture, and usage of a self-service model for enterprise data delivery: The Duke Enterprise Data Unified Content Explorer (DEDUCE)

    Science.gov (United States)

    Horvath, Monica M.; Rusincovitch, Shelley A.; Brinson, Stephanie; Shang, Howard C.; Evans, Steve; Ferranti, Jeffrey M.

    2015-01-01

    Purpose Data generated in the care of patients are widely used to support clinical research and quality improvement, which has hastened the development of self-service query tools. User interface design for such tools, execution of query activity, and underlying application architecture have not been widely reported, and existing tools reflect a wide heterogeneity of methods and technical frameworks. We describe the design, application architecture, and use of a self-service model for enterprise data delivery within Duke Medicine. Methods Our query platform, the Duke Enterprise Data Unified Content Explorer (DEDUCE), supports enhanced data exploration, cohort identification, and data extraction from our enterprise data warehouse (EDW) using a series of modular environments that interact with a central keystone module, Cohort Manager (CM). A data-driven application architecture is implemented through three components: an application data dictionary, the concept of “smart dimensions”, and dynamically-generated user interfaces. Results DEDUCE CM allows flexible hierarchies of EDW queries within a grid-like workspace. A cohort “join” functionality allows switching between filters based on criteria occurring within or across patient encounters. To date, 674 users have been trained and activated in DEDUCE, and logon activity shows a steady increase, with variability between months. A comparison of filter conditions and export criteria shows that these activities have different patterns of usage across subject areas. Conclusions Organizations with sophisticated EDWs may find that users benefit from development of advanced query functionality, complimentary to the user interfaces and infrastructure used in other well-published models. Driven by its EDW context, the DEDUCE application architecture was also designed to be responsive to source data and to allow modification through alterations in metadata rather than programming, allowing an agile response to source

  9. Modular design, application architecture, and usage of a self-service model for enterprise data delivery: the Duke Enterprise Data Unified Content Explorer (DEDUCE).

    Science.gov (United States)

    Horvath, Monica M; Rusincovitch, Shelley A; Brinson, Stephanie; Shang, Howard C; Evans, Steve; Ferranti, Jeffrey M

    2014-12-01

    Data generated in the care of patients are widely used to support clinical research and quality improvement, which has hastened the development of self-service query tools. User interface design for such tools, execution of query activity, and underlying application architecture have not been widely reported, and existing tools reflect a wide heterogeneity of methods and technical frameworks. We describe the design, application architecture, and use of a self-service model for enterprise data delivery within Duke Medicine. Our query platform, the Duke Enterprise Data Unified Content Explorer (DEDUCE), supports enhanced data exploration, cohort identification, and data extraction from our enterprise data warehouse (EDW) using a series of modular environments that interact with a central keystone module, Cohort Manager (CM). A data-driven application architecture is implemented through three components: an application data dictionary, the concept of "smart dimensions", and dynamically-generated user interfaces. DEDUCE CM allows flexible hierarchies of EDW queries within a grid-like workspace. A cohort "join" functionality allows switching between filters based on criteria occurring within or across patient encounters. To date, 674 users have been trained and activated in DEDUCE, and logon activity shows a steady increase, with variability between months. A comparison of filter conditions and export criteria shows that these activities have different patterns of usage across subject areas. Organizations with sophisticated EDWs may find that users benefit from development of advanced query functionality, complimentary to the user interfaces and infrastructure used in other well-published models. Driven by its EDW context, the DEDUCE application architecture was also designed to be responsive to source data and to allow modification through alterations in metadata rather than programming, allowing an agile response to source system changes. Copyright © 2014 Elsevier

  10. 2000 Survey of Distributed Spacecraft Technologies and Architectures for NASA's Earth Science Enterprise in the 2010-2025 Timeframe

    Science.gov (United States)

    Ticker, Ronald L.; Azzolini, John D.

    2000-01-01

    The study investigates NASA's Earth Science Enterprise needs for Distributed Spacecraft Technologies in the 2010-2025 timeframe. In particular, the study focused on the Earth Science Vision Initiative and extrapolation of the measurement architecture from the 2002-2010 time period. Earth Science Enterprise documents were reviewed. Interviews were conducted with a number of Earth scientists and technologists. fundamental principles of formation flying were also explored. The results led to the development of four notional distribution spacecraft architectures. These four notional architectures (global constellations, virtual platforms, precision formation flying, and sensorwebs) are presented. They broadly and generically cover the distributed spacecraft architectures needed by Earth Science in the post-2010 era. These notional architectures are used to identify technology needs and drivers. Technology needs are subsequently grouped into five categories: Systems and architecture development tools; Miniaturization, production, manufacture, test and calibration; Data networks and information management; Orbit control, planning and operations; and Launch and deployment. The current state of the art and expected developments are explored. High-value technology areas are identified for possible future funding emphasis.

  11. DAsHER CD: Developing a Data-Oriented Human-Centric Enterprise Architecture for EarthCube

    Science.gov (United States)

    Yang, C. P.; Yu, M.; Sun, M.; Qin, H.; Robinson, E.

    2015-12-01

    One of the biggest challenges that face Earth scientists is the resource discovery, access, and sharing in a desired fashion. EarthCube is targeted to enable geoscientists to address the challenges by fostering community-governed efforts that develop a common cyberinfrastructure for the purpose of collecting, accessing, analyzing, sharing and visualizing all forms of data and related resources, through the use of advanced technological and computational capabilities. Here we design an Enterprise Architecture (EA) for EarthCube to facilitate the knowledge management, communication and human collaboration in pursuit of the unprecedented data sharing across the geosciences. The design results will provide EarthCube a reference framework for developing geoscience cyberinfrastructure collaborated by different stakeholders, and identifying topics which should invoke high interest in the community. The development of this EarthCube EA framework leverages popular frameworks, such as Zachman, Gartner, DoDAF, and FEAF. The science driver of this design is the needs from EarthCube community, including the analyzed user requirements from EarthCube End User Workshop reports and EarthCube working group roadmaps, and feedbacks or comments from scientists obtained by organizing workshops. The final product of this Enterprise Architecture is a four-volume reference document: 1) Volume one is this document and comprises an executive summary of the EarthCube architecture, serving as an overview in the initial phases of architecture development; 2) Volume two is the major body of the design product. It outlines all the architectural design components or viewpoints; 3) Volume three provides taxonomy of the EarthCube enterprise augmented with semantics relations; 4) Volume four describes an example of utilizing this architecture for a geoscience project.

  12. DOD Business Systems Modernization: Military Departments Need to Strengthen Management of Enterprise Architecture Programs

    National Research Council Canada - National Science Library

    Hite, Randolph C; Johnson, Tonia; Eagle, Timothy; Epps, Elena; Holland, Michael; Lakhmani, Neela; LaPaza, Rebecca; Le, Anh; Paintsil, Freda

    2008-01-01

    .... Our framework for managing and evaluating the status of architecture programs consists of 31 core elements related to architecture governance, content, use, and measurement that are associated...

  13. MACCIS 2.0 - An Architecture Description Framework for Technical Infostructures and Their Enterprise Environment

    National Research Council Canada - National Science Library

    Elvesaeter, Brian; Neple, Tor; Aagedal, Jan O; Rolfsen, Rolf K; Stensli, Ole-Oevind

    2004-01-01

    This paper presents the MACCIS 2.0 framework. MACCIS is an architecture description framework that defines architectural artefacts that are used to describe technical information infrastructures (infostructures...

  14. [Determine and Implement Updates to Be Made to MODEAR (Mission Operations Data Enterprise Architecture Repository)

    Science.gov (United States)

    Fanourakis, Sofia

    2015-01-01

    My main project was to determine and implement updates to be made to MODEAR (Mission Operations Data Enterprise Architecture Repository) process definitions to be used for CST-100 (Crew Space Transportation-100) related missions. Emphasis was placed on the scheduling aspect of the processes. In addition, I was to complete other tasks as given. Some of the additional tasks were: to create pass-through command look-up tables for the flight controllers, finish one of the MDT (Mission Operations Directorate Display Tool) displays, gather data on what is included in the CST-100 public data, develop a VBA (Visual Basic for Applications) script to create a csv (Comma-Separated Values) file with specific information from spreadsheets containing command data, create a command script for the November MCC-ASIL (Mission Control Center-Avionics System Integration Laboratory) testing, and take notes for one of the TCVB (Terminal Configured Vehicle B-737) meetings. In order to make progress in my main project I scheduled meetings with the appropriate subject matter experts, prepared material for the meetings, and assisted in the discussions in order to understand the process or processes at hand. After such discussions I made updates to various MODEAR processes and process graphics. These meetings have resulted in significant updates to the processes that were discussed. In addition, the discussions have helped the departments responsible for these processes better understand the work ahead and provided material to help document how their products are created. I completed my other tasks utilizing resources available to me and, when necessary, consulting with the subject matter experts. Outputs resulting from my other tasks were: two completed and one partially completed pass through command look-up tables for the fight controllers, significant updates to one of the MDT displays, a spreadsheet containing data on what is included in the CST-100 public data, a tool to create a csv

  15. Migration of the Japanese healthcare enterprise from a financial to integrated management: strategy and architecture.

    Science.gov (United States)

    Akiyama, M

    2001-01-01

    The Hospital Information System (HIS) has been positioned as the hub of the healthcare information management architecture. In Japan, the billing system assigns an "insurance disease names" to performed exams based on the diagnosis type. Departmental systems provide localized, departmental services, such as order receipt and diagnostic reporting, but do not provide patient demographic information. The system above has many problems. The departmental system's terminals and the HIS's terminals are not integrated. Duplicate data entry introduces errors and increases workloads. Order and exam data managed by the HIS can be sent to the billing system, but departmental data cannot usually be entered. Additionally, billing systems usually keep departmental data for only a short time before it is deleted. The billing system provides payment based on what is entered. The billing system is oriented towards diagnoses. Most importantly, the system is geared towards generating billing reports rather than at providing high-quality patient care. The role of the application server is that of a mediator between system components. Data and events generated by system components are sent to the application server that routes them to appropriate destinations. It also records all system events, including state changes to clinical data, access of clinical data and so on. Finally, the Resource Management System identifies all system resources available to the enterprise. The departmental systems are responsible for managing data and clinical processes at a departmental level. The client interacts with the system via the application server, which provides a general set of system-level functions. The system is implemented using current technologies CORBA and HTTP. System data is collected by the application server and assembled into XML documents for delivery to clients. Clients can access these URLs using standard HTTP clients, since each department provides an HTTP compliant web

  16. An architecture based on SOA and virtual enterprise principles: OpenNebula for cloud deployment

    CSIR Research Space (South Africa)

    Mvelase, P

    2012-04-01

    Full Text Available Today enterprises have to survive in a dynamically changing business environment. Cloud computing presents a new business model where the Information Technology services supporting the business are provided by partners rather than in-house. The idea...

  17. IT process architectures for enterprises development: A survey from a maturity model perspective

    NARCIS (Netherlands)

    Santana Tapia, R.G.

    During the last years much has been published about IT governance. Close to the success of many governance efforts are the business frameworks, quality models, and technology standards that help enterprises improve processes, customer service, quality of products, and control. In this paper we i)

  18. Defense Logistics Agency Did Not Fully Implement the Business Enterprise Architecture Procure-to-Pay Business Process in the Enterprise Business System

    Science.gov (United States)

    2014-10-28

    change. Enterprise Business System In August 2000, DLA began developing its Enterprise Resource Planning ( ERP ) system by initiating the Business...the EBS core system. EBS became the ERP system solution supporting DLA nonenergy commodity activities. DLA subsequently enhanced its EBS...capabilities by adding SAP software that supported DLA Enterprise Operational Accounting, real property, and inventory management functions. As part of the

  19. An agent-based peer-to-peer architecture for semantic discovery of manufacturing services across virtual enterprises

    Science.gov (United States)

    Zhang, Wenyu; Zhang, Shuai; Cai, Ming; Jian, Wu

    2015-04-01

    With the development of virtual enterprise (VE) paradigm, the usage of serviceoriented architecture (SOA) is increasingly being considered for facilitating the integration and utilisation of distributed manufacturing resources. However, due to the heterogeneous nature among VEs, the dynamic nature of a VE and the autonomous nature of each VE member, the lack of both sophisticated coordination mechanism in the popular centralised infrastructure and semantic expressivity in the existing SOA standards make the current centralised, syntactic service discovery method undesirable. This motivates the proposed agent-based peer-to-peer (P2P) architecture for semantic discovery of manufacturing services across VEs. Multi-agent technology provides autonomous and flexible problemsolving capabilities in dynamic and adaptive VE environments. Peer-to-peer overlay provides highly scalable coupling across decentralised VEs, each of which exhibiting as a peer composed of multiple agents dealing with manufacturing services. The proposed architecture utilises a novel, efficient, two-stage search strategy - semantic peer discovery and semantic service discovery - to handle the complex searches of manufacturing services across VEs through fast peer filtering. The operation and experimental evaluation of the prototype system are presented to validate the implementation of the proposed approach.

  20. A Java-based enterprise system architecture for implementing a continuously supported and entirely Web-based exercise solution.

    Science.gov (United States)

    Wang, Zhihui; Kiryu, Tohru

    2006-04-01

    Since machine-based exercise still uses local facilities, it is affected by time and place. We designed a web-based system architecture based on the Java 2 Enterprise Edition that can accomplish continuously supported machine-based exercise. In this system, exercise programs and machines are loosely coupled and dynamically integrated on the site of exercise via the Internet. We then extended the conventional health promotion model, which contains three types of players (users, exercise trainers, and manufacturers), by adding a new player: exercise program creators. Moreover, we developed a self-describing strategy to accommodate a variety of exercise programs and provide ease of use to users on the web. We illustrate our novel design with examples taken from our feasibility study on a web-based cycle ergometer exercise system. A biosignal-based workload control approach was introduced to ensure that users performed appropriate exercise alone.

  1. Developing IT Strategic Planning Using Mobile Enterprise Architecture In The Academic Process of Atma Jaya Makassar University

    Directory of Open Access Journals (Sweden)

    Astrid Lestari Tungadi

    2017-03-01

    Full Text Available The purpose of this research was to examine the feasibility of the development of mobile enterprise strategic plan, analyze the academic process and the utilization of information technology (IT, and generate documentation IT strategic planning by implementing Mobile Enterprise Architecture in the academic process of Atma Jaya University in Makassar. Data were taken from distributing questionnaires to 297 respondents and conducting interviews to 18 respondents. Data were examined using SWOT analysis, the incorporation of academic scorecard analysis and IT balanced scorecard analysis, financial analysis, as well as analytic hierarchy process (AHP. SWOT analysis results indicate that case study is in a weak position, which possibly never take advantage of opportunities since the weakness of the stand or the power is not enough to work on it. In addition, the results of the performance analysis of the utilization of information technology using the Balanced Scorecard analysis show that the average performance is sufficient. The result of documentation of IT strategic planning was analyzed with financial analysis indicating the feasibility of implementation because it provides benefits for university of 141,32%. Furthermore, Analytic Hierarchy Process (AHP to determine the priority of IT strategy proposals shows that the main priority is to develop portal for student and lecturer.

  2. A Multi-Level Investigation into the Antecedents of Enterprise Architecture (EA) Assimilation in the U.S. Federal Government: A Longitudinal Mixed Methods Research Study

    Science.gov (United States)

    Makiya, George K.

    2012-01-01

    This dissertation reports on a multi-dimensional longitudinal investigation of the factors that influence Enterprise Architecture (EA) diffusion and assimilation within the U.S. federal government. The study uses publicly available datasets of 123 U.S. federal departments and agencies, as well as interview data among CIOs and EA managers within…

  3. eHealth integration and interoperability issues: towards a solution through enterprise architecture.

    Science.gov (United States)

    Adenuga, Olugbenga A; Kekwaletswe, Ray M; Coleman, Alfred

    2015-01-01

    Investments in healthcare information and communication technology (ICT) and health information systems (HIS) continue to increase. This is creating immense pressure on healthcare ICT and HIS to deliver and show significance in such investments in technology. It is discovered in this study that integration and interoperability contribute largely to this failure in ICT and HIS investment in healthcare, thus resulting in the need towards healthcare architecture for eHealth. This study proposes an eHealth architectural model that accommodates requirement based on healthcare need, system, implementer, and hardware requirements. The model is adaptable and examines the developer's and user's views that systems hold high hopes for their potential to change traditional organizational design, intelligence, and decision-making.

  4. Emerging opportunities in enterprise integration with open architecture computer numerical controls

    Science.gov (United States)

    Hudson, Christopher A.

    1997-01-01

    The shift to open-architecture machine tool computer numerical controls is providing new opportunities for metal working oriented manufacturers to streamline the entire 'art to part' process. Production cycle times, accuracy, consistency, predictability and process reliability are just some of the factors that can be improved, leading to better manufactured product at lower costs. Open architecture controllers are allowing manufacturers to apply general purpose software and hardware tools increase where previous approaches relied on proprietary and unique hardware and software. This includes DNC, SCADA, CAD, and CAM, where the increasing use of general purpose components is leading to lower cost system that are also more reliable and robust than the past proprietary approaches. In addition, a number of new opportunities exist, which in the past were likely impractical due to cost or performance constraints.

  5. Beneath the surface of the heritage enterprise. Governmentality and cultural representation of rural architecture in Portugal

    OpenAIRE

    Silva, Luís

    2011-01-01

    This article focuses on the construction of heritage in rural Portugal. Drawing on anthropological fieldwork in the village of Castelo Rodrigo, it analyses the extensive protection and exhibition of domestic architecture in the framework of a State-led local development programme. By bringing in the messiness of daily practices, the article goes beyond neat theoretical formulations in the study of heritage such as Foucault’s theory of “governmentality” and Kirshenblatt-Gimblett’s notion of “s...

  6. A roadmap for caGrid, an enterprise Grid architecture for biomedical research.

    Science.gov (United States)

    Saltz, Joel; Hastings, Shannon; Langella, Stephen; Oster, Scott; Kurc, Tahsin; Payne, Philip; Ferreira, Renato; Plale, Beth; Goble, Carole; Ervin, David; Sharma, Ashish; Pan, Tony; Permar, Justin; Brezany, Peter; Siebenlist, Frank; Madduri, Ravi; Foster, Ian; Shanbhag, Krishnakant; Mead, Charlie; Chue Hong, Neil

    2008-01-01

    caGrid is a middleware system which combines the Grid computing, the service oriented architecture, and the model driven architecture paradigms to support development of interoperable data and analytical resources and federation of such resources in a Grid environment. The functionality provided by caGrid is an essential and integral component of the cancer Biomedical Informatics Grid (caBIG) program. This program is established by the National Cancer Institute as a nationwide effort to develop enabling informatics technologies for collaborative, multi-institutional biomedical research with the overarching goal of accelerating translational cancer research. Although the main application domain for caGrid is cancer research, the infrastructure provides a generic framework that can be employed in other biomedical research and healthcare domains. The development of caGrid is an ongoing effort, adding new functionality and improvements based on feedback and use cases from the community. This paper provides an overview of potential future architecture and tooling directions and areas of improvement for caGrid and caGrid-like systems. This summary is based on discussions at a roadmap workshop held in February with participants from biomedical research, Grid computing, and high performance computing communities.

  7. A Service Architecture Solution for Mobile Enterprise Resources: A Case Study in the Banking Industry

    Science.gov (United States)

    Garcia-Gonzalez, Juan P.; Gacitua-Decar, Geronica; Pahl, Claus

    Providing mobility to participants of business processes is an increasing trend in the banking sector. Independence of a physical place to interact with clients, while been able to use the information managed in the banking applications is one, of the benefits of mobile business processes. Challenges arising from this approach include to deal with a scenario of occasionally connected communication; security issues regarding the exposition of internal information on devices-that could be lost-; and restrictions on the capacity of mobile devices. This paper presents our experience in implementing a service-based architecture solution to extend centralised resources from a financial institution to a mobile platform.

  8. caGrid 1.0: a Grid enterprise architecture for cancer research.

    Science.gov (United States)

    Oster, Scott; Langella, Stephen; Hastings, Shannon; Ervin, David; Madduri, Ravi; Kurc, Tahsin; Siebenlist, Frank; Covitz, Peter; Shanbhag, Krishnakant; Foster, Ian; Saltz, Joel

    2007-10-11

    caGrid is the core Grid architecture of the NCI-sponsored cancer Biomedical Informatics Grid (caBIG) program. The current release, caGrid version 1.0, is developed as the production Grid software infrastructure of caBIG. Based on feedback from adopters of the previous version (caGrid 0.5), it has been significantly enhanced with new features and improvements to existing components. This paper presents an overview of caGrid 1.0, its main components, and enhancements over caGrid 0.5.

  9. Information architecture considerations in designing a comprehensive tuberculosis enterprise system in Western Kenya.

    Science.gov (United States)

    Gichoya, Judy; Pearce, Chris; Wickramasinghe, Nilmini

    2013-01-01

    Kenya ranks among the twenty-two countries that collectively contribute about 80% of the world's Tuberculosis cases; with a 50-200 fold increased risk of tuberculosis in HIV infected persons versus non-HIV hosts. Contemporaneously, there is an increase in mobile penetration and its use to support healthcare throughout Africa. Many are skeptical that such m-health solutions are unsustainable and not scalable. We seek to design a scalable, pervasive m-health solution for Tuberculosis care to become a use case for sustainable and scalable health IT in limited resource settings. We combine agile design principles and user-centered design to develop the architecture needed for this initiative. Furthermore, the architecture runs on multiple devices integrated to deliver functionality critical for successful Health IT implementation in limited resource settings. It is anticipated that once fully implemented, the proposed m-health solution will facilitate superior monitoring and management of Tuberculosis and thereby reduce the alarming statistic regarding this disease in this region.

  10. THE ENHANCEMENT OF STRATEGIC AND OPERATIONAL PERFORMANCE THROUGH ENTERPRISE ARCHITECTURE IN XYZ’S DISTRICT ATTORNEY OFFICES

    Directory of Open Access Journals (Sweden)

    Frisa Erika

    2013-10-01

    Full Text Available The deteriorating image of law enforcement agencies in serving the needs of nowadays community is making the chiefs of XYZ’s district attorney offices to search the best way so that the law service in their offices can be better. This problem is the general reflection of how bad the public service in law’s field is in our country. For that noble purpose, the chiefs see that there is a chance to use the ability of system and information technology. That system is not only for the necessary needs in district attorney office but it is also combined in the existing process in security and court. The chief of office feels that the enhancement performance will be obtained easier if there is the same system and technology and are designed carefully. Within this paper, the researcher uses the framework of Enterprise Architecture to develop the needed system and technology so that it can be realized strategically and operationally much better and can be accounted. The result is the current time conservative service system and have the quality of office automation systems is gradually planned to change into automation for the next two or three years. Therefore, the connection and the cooperation between the attorney, the police and the court will be more harmonic, thus gradually increased the service to the community.

  11. Architecture

    OpenAIRE

    Clear, Nic

    2014-01-01

    When discussing science fiction’s relationship with architecture, the usual practice is to look at the architecture “in” science fiction—in particular, the architecture in SF films (see Kuhn 75-143) since the spaces of literary SF present obvious difficulties as they have to be imagined. In this essay, that relationship will be reversed: I will instead discuss science fiction “in” architecture, mapping out a number of architectural movements and projects that can be viewed explicitly as scien...

  12. Agent-based enterprise integration

    Energy Technology Data Exchange (ETDEWEB)

    N. M. Berry; C. M. Pancerella

    1998-12-01

    The authors are developing and deploying software agents in an enterprise information architecture such that the agents manage enterprise resources and facilitate user interaction with these resources. The enterprise agents are built on top of a robust software architecture for data exchange and tool integration across heterogeneous hardware and software. The resulting distributed multi-agent system serves as a method of enhancing enterprises in the following ways: providing users with knowledge about enterprise resources and applications; accessing the dynamically changing enterprise; locating enterprise applications and services; and improving search capabilities for applications and data. Furthermore, agents can access non-agents (i.e., databases and tools) through the enterprise framework. The ultimate target of the effort is the user; they are attempting to increase user productivity in the enterprise. This paper describes their design and early implementation and discusses the planned future work.

  13. Lennert's Lymphoma

    International Nuclear Information System (INIS)

    Narayanrao, Suresh T.; Pillai, R.; Nada, Aymen; Hasan, Suhel

    2005-01-01

    Lymphoepithelioid cell lymphoma (Lennert's lymphoma) is a rare morphological variant of peripheral T-cell lymphoma characterized by the presence of numerous clusters of epithelioid histiocytes without formation of discrete granulomas and the intervening atypical lymphocytes. Lennert's lymphoma is often misinterpreted as granulomatous lymphadenitis or Hodgkin's disease. This report describes fine needle aspiration cytology and histological findings in a case of Lennert's lymphoma. (author)

  14. DOD Business Systems Modernization: Key Navy Programs' Compliance with DOD's Federated Business Enterprise Architecture Needs to be Adequately Demonstrated

    National Research Council Canada - National Science Library

    Hite, Randolph C; Lakhmani, Neela; Barkakati, Nabajyoti; Doherty, Neil; Glover, Nancy; Longcore, Emily; Holland, Michael; Le, Anh; Leiling, Josh; McCracken, Lee; Srikanth, Sushmita

    2008-01-01

    .... In particular, the programs BEA compliance assessments did not: * Include all relevant architecture products, such as products that specify the technical standards needed to promote interoperability among related systems...

  15. Modelling a Global EPCM (Engineering, Procurement and Construction Management Enterprise

    Directory of Open Access Journals (Sweden)

    Sekhar Chattopadhyay

    2010-03-01

    Full Text Available This paper investigates the applicability of enterprise architectures in the context of current business environment by examining the application of Purdue Enterprise Reference Architecture to WorleyParsons, a global engineering, procurement and construction management enterprise, under the backdrop of a similar study carried out on Fluor Daniel during mid-nineties of the last century. The outcome of this study recommends the need for new enterprise architecture, the People-Centric Enterprise Architecture that not only focuses on human dimension in modern enterprises as the central thread, but also includes more business characteristics of the enterprise other than engineerings.

  16. The Enterprise architecture and modeling of manufacturing business process of in Goriške opekarne, PLC

    OpenAIRE

    Marčetič, Marko

    2016-01-01

    Inspite of persisting economic crisis some companies still try to invest in informatics and information technology systems. They are fully aware of the fact that this kind of support executes process improvements that optimize businesss. Further on a successful productivity is based on a precisely formed working strategy,which is a starting point for development of informatics and business architecture framework. This will enable the business process the achievement of production aims a...

  17. The Changing Role of the Enterprise Architect

    DEFF Research Database (Denmark)

    Gøtze, John

    2013-01-01

    Enterprise architecture is practiced in different ways, and there are different types of enterprise architects with quite different roles. This paper looks closer at the role of enterprise architects and the importance of the enterprise architects’ understanding of boundary issues in their practice....... The paper suggests that enterprise architects must focus on problem-finding more than problem-solving, and should develop not just more dialectic skills, but also dialogic skills. The paper also argues that the enterprise architects must gain a deeper understanding of the enterprise, and need to start...... working with other enterprise disciplines....

  18. Hodgkin lymphoma

    Science.gov (United States)

    Lymphoma - Hodgkin; Hodgkin disease; Cancer - Hodgkin lymphoma ... to 70 years old. Past infection with the Epstein-Barr virus ( EBV ) is thought to contribute to some cases. People with HIV infection are at increased risk compared to the general population.

  19. Management and Engineering of Virtual Enterprises

    DEFF Research Database (Denmark)

    Tølle, Martin

    ) Component layer: consists of reusable components and modules. - Each layer builds on the previous one, i.e. the VE concept is captured in VERA, and the VERA can be used to structure each of the VERAM components. * C) A methodology for virtual enterprise named VEM (Virtual Enterprise Methodology) - One...... to the set up of virtual enterprises. Types of work preparation include definitions (e.g. shared terminology), ICT support (e.g. infrastructure and applications), procedures (e.g. how to set up virtual enterprises, partner selection), reference models (e.g. contract models and product structure) and the like....... * B) A framework and a reference architecture for virtual enterprises named VERAM (Virtual Enterprise Reference Architecture and Methodology) and VERA (Virtual Enterprise Reference Architecture) respectively. - VERAM is a framework that structures the body of knowledge related to preparation, set up...

  20. Consolidated Afloat Networks and Enterprise Services (CANES)

    Science.gov (United States)

    2016-03-01

    Information Assurance IATO - Interim Authority to Operate ICD - Initial Capability Document IEA - Information Enterprise Architecture IOC - Initial...2016 Major Automated Information System Annual Report Consolidated Afloat Networks and Enterprise Services (CANES) Defense Acquisition Management...Executive DoD - Department of Defense DoDAF - DoD Architecture Framework FD - Full Deployment FDD - Full Deployment Decision FY - Fiscal Year IA

  1. Anaplastic Large Cell Lymphoma

    Science.gov (United States)

    ... Non-Hodgkin Lymphoma Peripheral T-Cell Lymphoma Primary Central Nervous System Lymphoma T-Cell Lymphoma Transformed Mycosis Fungoides Waldenstrom Macroglobulinemia Young Adult Lymphoma Overview Treatment Options Relapsed/Refractory Long-term ...

  2. Mantle Cell Lymphoma

    Science.gov (United States)

    ... Non-Hodgkin Lymphoma Peripheral T-Cell Lymphoma Primary Central Nervous System Lymphoma T-Cell Lymphoma Transformed Mycosis Fungoides Waldenstrom Macroglobulinemia Young Adult Lymphoma Overview Treatment Options Relapsed/Refractory Long-term ...

  3. Marginal Zone Lymphoma

    Science.gov (United States)

    ... Non-Hodgkin Lymphoma Peripheral T-Cell Lymphoma Primary Central Nervous System Lymphoma T-Cell Lymphoma Transformed Mycosis Fungoides Waldenstrom Macroglobulinemia Young Adult Lymphoma Overview Treatment Options Relapsed/Refractory Long-term ...

  4. Architecture Governance: The Importance of Architecture Governance for Achieving Operationally Responsive Ground Systems

    Science.gov (United States)

    Kolar, Mike; Estefan, Jeff; Giovannoni, Brian; Barkley, Erik

    2011-01-01

    Topics covered (1) Why Governance and Why Now? (2) Characteristics of Architecture Governance (3) Strategic Elements (3a) Architectural Principles (3b) Architecture Board (3c) Architecture Compliance (4) Architecture Governance Infusion Process. Governance is concerned with decision making (i.e., setting directions, establishing standards and principles, and prioritizing investments). Architecture governance is the practice and orientation by which enterprise architectures and other architectures are managed and controlled at an enterprise-wide level

  5. Adding agility to Enterprise Process and Data Engineering

    Directory of Open Access Journals (Sweden)

    Sergey Zykov

    2016-04-01

    Full Text Available Managing development of large and complex enterprise architectures is a key problem in enterprise engineering. Nowadays one of the breathtaking topics considering enterprise context is real-time system agility. The paper discusses an appropriate general architecture pattern and provides insights how dynamic process management environment could be made. We survey general enterprise software architecture and current agility problems. We introduce a special component called a process knowledge base and justify its crucial role in achieving agility within the enterprise. We study both the architecture of the process knowledge base as well as formal basis for its implementation which relies upon the type theory.

  6. Developing the Business Model – a Methodology for Virtual Enterprises

    DEFF Research Database (Denmark)

    Tølle, Martin; Vesterager, Johan

    2003-01-01

    up an Enterprise Network, which works as a breeding ground for setting up VEs. The VEM applies the Virtual Enterprise Reference Architecture (VERA) as an underlying structure. VERA is a specialisation of GERA, which is a component of the GERAM Framework (Generalised Enterprise Reference Architecture...

  7. Conjunctival Lymphoma

    DEFF Research Database (Denmark)

    Kirkegaard, Marina M; Rasmussen, Peter K; Coupland, Sarah E

    2016-01-01

    IMPORTANCE: To date, the clinical features of the various subtypes of conjunctival lymphoma (CL) have not been previously evaluated in a large cohort. OBJECTIVE: To characterize subtype-specific clinical features of CL and their effect on patient outcome. DESIGN, SETTING, AND PARTICIPANTS...... age was 61.3 years, and 55.1% (145 of 263) were female. All lymphomas were of B-cell type. The most frequent subtype was extranodal marginal zone lymphoma (EMZL) (68.4% [180 of 263]), followed by follicular lymphoma (FL) (16.3% [43 of 263]), mantle cell lymphoma (MCL) (6.8% [18 of 263]), and diffuse...... large B-cell lymphoma (DLBCL) (4.6% [12 of 263). Conjunctival lymphoma commonly manifested in elderly individuals (age range, 60-70 years old), with EMZL having a female predilection (57.8% [104 of 180]) and MCL having a marked male predominance (77.8% [14 of 18]). Unlike EMZL and FL, DLBCL and MCL were...

  8. Reference models supporting enterprise networks and virtual enterprises

    DEFF Research Database (Denmark)

    Tølle, Martin; Bernus, Peter

    2003-01-01

    This article analyses different types of reference models applicable to support the set up and (re)configuration of Virtual Enterprises (VEs). Reference models are models capturing concepts common to VEs aiming to convert the task of setting up of VE into a configuration task, and hence reducing...... the time needed for VE creation. The reference models are analysed through a mapping onto the Virtual Enterprise Reference Architecture (VERA) based upon GERAM and created in the IMS GLOBEMEN project....

  9. Ovarian lymphoma

    International Nuclear Information System (INIS)

    Bonet Fonseca, Ivan; Diaz Anaya, Amnia; Francis, Tabu

    2012-01-01

    50 % of pediatric oncologic pathology corresponds to mass or solid tumors, reaching about 20 % of total abdomen. The tumors that most frequently occur in the abdomen are nephroblastoma or Wilms tumor, Burkitts lymphoma, neuroblastoma, and ovarian germ cell tumors

  10. Six Sigma Driven Enterprise Model Transformation

    Directory of Open Access Journals (Sweden)

    Raymond Vella

    2009-10-01

    Full Text Available Enterprise architecture methods provide a structured system to understand enterprise activities. However, existing enterprise modelling methodologies take static views of the enterprise and do not naturally lead to a path of improvement during enterprise model transformation. This paper discusses the need for a methodology to facilitate changes for improvement in an enterprise. The six sigma methodology is proposed as the tool to facilitate progressive and continual Enterprise Model Transformation to allow businesses to adapt to meet increased customer expectation and global competition. An alignment of six sigma with phases of GERAM life cycle is described with inclusion of Critical-To-Satisfaction (CTS requirements. The synergies of combining the two methodologies are presented in an effort to provide a more culturally embedded framework for Enterprise Model Transformation that builds on the success of six sigma.

  11. Primary lymphoma of the brain

    Science.gov (United States)

    Brain lymphoma; Cerebral lymphoma; Primary lymphoma of the central nervous system; Lymphoma - brain ... The cause of primary brain lymphoma is not known. People with a weakened immune system are at high risk for primary lymphoma of the brain. ...

  12. Enterprise Middleware for Scientific Data

    Energy Technology Data Exchange (ETDEWEB)

    Thomson, Judi; Chappell, Alan R.; Almquist, Justin P.

    2003-02-27

    We describe an enterprise middleware system that integrates, from a user’s perspective, data located on disparate data storage devices without imposing additional requirements upon those storage mechanisms. The system provides advanced search capabilities by exploiting a repository of metadata that describes the integrated data. This search mechanism integrates information from a collection of XML metadata documents with diverse schema. Users construct queries using familiar search terms, and the enterprise system uses domain representations and vocabulary mappings to translate the user’s query, expanding the search to include other potentially relevant data. The enterprise architecture allows flexibility with respect to domain dependent processing of user data and metadata

  13. Global Information Enterprise (GIE) Modeling and Simulation (GIESIM)

    National Research Council Canada - National Science Library

    Bell, Paul

    2005-01-01

    ... AND S) toolkits into the Global Information Enterprise (GIE) Modeling and Simulation (GIESim) framework to create effective user analysis of candidate communications architectures and technologies...

  14. Lymphoma of the eyelid

    DEFF Research Database (Denmark)

    Svendsen, Frederik Holm; Heegaard, Steffen

    2017-01-01

    Lymphoma of the eyelid constitutes 5% of ocular adnexal lymphoma. In previously published cases, 56% of lymphomas of the eyelid are of B-cell origin and 44% are of T-cell origin. The most frequent B-cell lymphomas are extranodal marginal zone lymphoma (27 cases-14%) and diffuse large B......-cell lymphoma (18 cases-9%). T-cell lymphomas are most frequently mycosis fungoides (25 cases-13%), extranodal natural killer/T-cell, nasal-type lymphoma (12 cases-6%), and primary cutaneous anaplastic large-cell lymphoma (12 cases-6%). This distribution differs from the distribution of ocular adnexal lymphoma...... and that of cutaneous lymphoma. The majority of subtypes occur in elderly patients, except for lymphoblastic lymphoma of B-cell and T-cell origin and Burkitt lymphoma, which occur in children and adolescents. Several subtypes have a male predominance, including peripheral T-cell lymphoma and Burkitt lymphoma. Only...

  15. A method for valuing architecture-based business transformation and measuring the value of solutions architecture

    OpenAIRE

    Slot, R.G.

    2010-01-01

    Enterprise and Solution Architecture are key in today’s business environment. It is surprising that the foundation and business case for these activities are nonexistent; the financial value for the business of these activities is largely undetermined. To determine business value of enterprise and solution architecture, this thesis shows how to measure and quantify, in business terms, the value of enterprise architecture-based on business transformation and the value of solution architecture.

  16. Enterprise Engineering Method supporting Six Sigma Approach

    OpenAIRE

    Jochem, Roland

    2007-01-01

    Enterprise Modeling (EM) is currently in operation either as a technique to represent and understand the structure and behavior of the enterprise, or as a technique to analyze business processes, and in many cases as support technique for business process reengineering. However, EM architectures and methodes for Enterprise Engineering can also used to support new management techniques like SIX SIGMA, because these new techniques need a clear, transparent and integrated definition and descript...

  17. Enterprise Engineering and Management at the Crossroads

    DEFF Research Database (Denmark)

    Bernus, Peter; Goranson, Ted; Gøtze, John

    2015-01-01

    The article provides an overview of the challenges and the state of the art of the discipline of Enterprise Architecture (EA), with emphasis on the challenges and future development opportunities of the underlying Information System (IS), and its IT implementation, the Enterprise Information Syst...... design and implementation, with the potential to solve these grand challenges....

  18. Lymphoma cytogenetics.

    Science.gov (United States)

    Dave, Bhavana J; Nelson, Marilu; Sanger, Warren G

    2011-12-01

    Lymphomas are a heterogeneous group of neoplasms with distinct morphologic, immunologic, and cytogenetic characteristics. Overlapping morphologic and immunophenotypic features often makes accurate diagnosis difficult. Cytogenetics helps simplify the diagnostic complexities presented in transforming and progressive lymphoid malignancies. Genetic studies using technical advances such as fluorescence in situ hybridization and the newer approaches of array comparative genomic hybridization and gene expression profiling play a critical and often defining role in the diagnosis, progression, prognosis, and therapeutic stratification. This article reviews characteristic cytogenetic abnormalities in specific subtypes of lymphomas at diagnosis, disease progression, and prognosis.

  19. Intraocular lymphoma

    Directory of Open Access Journals (Sweden)

    Li-Juan Tang

    2017-08-01

    Full Text Available Intraocular lymphoma (IOL is a rare lymphocytic malignancy which contains two main distinct forms. Primary intraocular lymphoma (PIOL is mainly a sub-type of primary central nervous system lymphoma (PCNSL. Alternatively, IOL can originate from outside the central nervous system (CNS by metastasizing to the eye. These tumors are known as secondary intraocular lymphoma (SIOL. The IOL can arise in the retina, uvea, vitreous, Bruch’s membrane and optic nerve. There are predominantly of B-cell origin; however there are also rare T-cell variants. Diagnosis remains challenging for ophthalmologists and pathologists, due to its ability to masquerade as noninfectious or infectious uveitis, white dot syndromes, or occasionally as other metastatic cancers. Laboratory tests include flow cytometry, immunocytochemistry, interleukin detection (IL-10: IL-6, ratio >1, and polymerase chain reaction (PCR amplification. Methotrexate-based systemic chemotherapy with external beam radiotherapy and intravitreal chemotherapy with methotrexate are useful for controlling the disease, but the prognosis remains poor. Therefore, it is important to make an early diagnose and treatment. This review is focused on the clinical manifestations, diagnosis, treatment and prognosis of the IOL.

  20. Breast lymphoma

    African Journals Online (AJOL)

    To fulfil the criteria for primary breast lymphoma, the following characteristics were reqUired: (I) technically adequate specimens; (iI) mammary tissue and lymphomatous infiltrate in close association; (iil) no evidence of concurrent widespread disease; and (iv) no previous. Haematology/Oncology Division, Department of ...

  1. Testicular lymphoma

    DEFF Research Database (Denmark)

    Møller, Michael Boe; d'Amore, F; Christensen, Bjarne Egelund

    1994-01-01

    In a Danish population-based non-Hodgkin's lymphoma registry, 2687 newly diagnosed patients were registered from 1983 to 1992. 39 had testicular involvement (TL) (incidence 0.26/10(5)/year). Median age was 71 years. 24 cases had localised and 15 had disseminated disease. Histologically, all cases...

  2. Hodgkin's Lymphoma

    Science.gov (United States)

    ... People who have had illnesses caused by the Epstein-Barr virus, such as infectious mononucleosis, are more likely to develop Hodgkin's lymphoma than are people who haven't had Epstein-Barr infections. By Mayo Clinic Staff . Mayo Clinic Footer ...

  3. PhoneGap for enterprise

    CERN Document Server

    Shotts, Kerri

    2014-01-01

    This book is intended for developers who wish to use PhoneGap to develop useful, rich, secure mobile applications for their enterprise environment. The book assumes you have working knowledge of PhoneGap, HTML5, CSS3, and JavaScript, and a reasonable understanding of networking and n-tier architectures.

  4. PICNIC Architecture.

    Science.gov (United States)

    Saranummi, Niilo

    2005-01-01

    The PICNIC architecture aims at supporting inter-enterprise integration and the facilitation of collaboration between healthcare organisations. The concept of a Regional Health Economy (RHE) is introduced to illustrate the varying nature of inter-enterprise collaboration between healthcare organisations collaborating in providing health services to citizens and patients in a regional setting. The PICNIC architecture comprises a number of PICNIC IT Services, the interfaces between them and presents a way to assemble these into a functioning Regional Health Care Network meeting the needs and concerns of its stakeholders. The PICNIC architecture is presented through a number of views relevant to different stakeholder groups. The stakeholders of the first view are national and regional health authorities and policy makers. The view describes how the architecture enables the implementation of national and regional health policies, strategies and organisational structures. The stakeholders of the second view, the service viewpoint, are the care providers, health professionals, patients and citizens. The view describes how the architecture supports and enables regional care delivery and process management including continuity of care (shared care) and citizen-centred health services. The stakeholders of the third view, the engineering view, are those that design, build and implement the RHCN. The view comprises four sub views: software engineering, IT services engineering, security and data. The proposed architecture is founded into the main stream of how distributed computing environments are evolving. The architecture is realised using the web services approach. A number of well established technology platforms and generic standards exist that can be used to implement the software components. The software components that are specified in PICNIC are implemented in Open Source.

  5. Enterprise interoperability ontology for SOC applied to logistics

    NARCIS (Netherlands)

    Hofman, W.J.

    2010-01-01

    The Service Oriented Architecture (SOA, [1]) can be applied to enterprise integration. It creates an Internet of services for enterprises. Service science [2] defines services in term of value propositions of enterprises to customers. Both service science and the Internet of services require a form

  6. National Positioning, Navigation, and Timing Architecture

    National Research Council Canada - National Science Library

    Huested, Patrick; Popejoy, Paul D

    2008-01-01

    .... The strategy is supported by vectors, or enterprise architecture elements, for using multiple PNT-related phenomenologies and interchangeable PNT solutions, PNT and Communications synergy, and co...

  7. Abdominal lymphadenopathy in tuberculosis and lymphoma: Differentiation with CT

    International Nuclear Information System (INIS)

    Shin, Yong Moon; Choi, Byung Ihn; Han, Joon Koo; Han, Man Chung; Song, Chi Sung; Yang, Seoung Oh

    1993-01-01

    Tuberculosis and lymphoma, these 2 dieases can present with lymphadenopathy in anywhere of the body. Therefore differentiation of tuberculosis from lymphoma is often difficult. CT scans of 17 patients with tuberculosis and 23 patients with lymphoma were retrospectively reviewed to evaluate the efficacy of CT scans in differentating adenopathy between tuberculosis and lymphoma. All the patients underwent abdominal CT scans with contrast enhancement before treatment. The size, internal architecture, distribution of lymph nodes, and associated findings on CT scans were analyzed. As compared with lymphoma, tuberculous lymphadenopathy showed 1) female preponderance (65%), 2) predilection for percolative lymph nodes (47%), 3) internal low attenuation in lymph nodes (82%), 4) cold abscess formation (24%). Characteristics of lymphoma on CT scans include 1) male preponderance (78%), 2) conglomeration of lymph nodes (39%), 3) homogeneous internal lymph node structure (83%). These results suggest that evaluation of the cahracteristics of lymphadenopathy on CT scans is helpful for differentiating between tuberculousis and lymphoma

  8. Angioimmunoblastic T-Cell Lymphoma

    Science.gov (United States)

    ... Non-Hodgkin Lymphoma Peripheral T-Cell Lymphoma Primary Central Nervous System Lymphoma T-Cell Lymphoma Transformed Mycosis Fungoides Waldenstrom Macroglobulinemia Young Adult Lymphoma Overview Treatment Options Relapsed/Refractory Long-term ...

  9. Peripheral T-Cell Lymphoma

    Science.gov (United States)

    ... Non-Hodgkin Lymphoma Peripheral T-Cell Lymphoma Primary Central Nervous System Lymphoma T-Cell Lymphoma Transformed Mycosis Fungoides Waldenstrom Macroglobulinemia Young Adult Lymphoma Overview Treatment Options Relapsed/Refractory Long-term ...

  10. Hodgkin lymphoma - children

    Science.gov (United States)

    ... families share common experiences may help ease your stress. American Childhood Cancer Organization - www.acco.org Leukemia and ... Cancer - Hodgkin lymphoma - children; Childhood Hodgkin lymphoma ... Cancer Institute website. Childhood Hodgkin lymphoma treatment (PDQ) - health professional ...

  11. A step-by-step methodology for enterprise interoperability projects

    Science.gov (United States)

    Chalmeta, Ricardo; Pazos, Verónica

    2015-05-01

    Enterprise interoperability is one of the key factors for enhancing enterprise competitiveness. Achieving enterprise interoperability is an extremely complex process which involves different technological, human and organisational elements. In this paper we present a framework to help enterprise interoperability. The framework has been developed taking into account the three domains of interoperability: Enterprise Modelling, Architecture and Platform and Ontologies. The main novelty of the framework in comparison to existing ones is that it includes a step-by-step methodology that explains how to carry out an enterprise interoperability project taking into account different interoperability views, like business, process, human resources, technology, knowledge and semantics.

  12. [Plasmablastic lymphoma].

    Science.gov (United States)

    Fernández-Álvarez, Rubén; Sancho, Juan-Manuel; Ribera, Josep-María

    2016-11-04

    Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of non-Hodgkin lymphoma that commonly occurs in human immunodeficiency virus (HIV)-positive individuals, and affects oral sites. Occasionally, it has been described in HIV-negative patients and involving non-oral sites. Pathologically, PBL is a high-grade B-cell lymphoma that displays the immunophenotype of a terminally differentiated B-lymphocyte with loss of B-cell markers (CD20) and expression of plasma-cell antigens. Epstein-Barr virus infection and MYC rearrangements are frequently observed. Treatment of PBL is challenging because of the lack of established treatment and poor outcomes, with median survival times shorter than one year. In this review, we discuss the clinical and epidemiologic spectrum of PBL as well as its distinct pathological features. Finally, we summarize the currently available approaches for the treatment of patients with PBL. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  13. A domestic model for successful implementation of enterprise resource planning (ERP systems in Iranian manufacturing enterprises

    Directory of Open Access Journals (Sweden)

    Mohammad Rahmani

    2012-01-01

    Full Text Available This research investigates the human-behavioral dimension of technology acceptance in enterprises. It is evident that accepting a technology depends on the underlying circumstances of the environment. We have approached this issue from two different angles of social and technological architecture. The research tries to explore proper enterprise architecture for ERP system acceptance. Social Architecture (SA is defined as the set of circumstances that makes people behave in a particular way. So behavior of persons (employees of an enterprise can be a function of SA. Hence acceptance of a system can be dictated by SA and manipulating SA can result in desirable success for a technology system. We have achieved various variables of social architecture and have examined their relevance to system acceptance and success in related enterprises (research domain beside technological architecture variables. The results have indicated that a special form of social and technological architecture can lead to success for ERP system in the enterprises of the research domain. This gave us a model of architecture.

  14. IT Service Management Architectures

    DEFF Research Database (Denmark)

    Tambo, Torben; Filtenborg, Jacob

    2018-01-01

    IT service providers tend to view their services as quasi-embedded in the client organisations infrastructure. Therefore, IT service providers lack a full picture of being an organisation with its own enterprise archicture. By systematically developing an enterprise architecture using the unifica...... the unification operating model, IT service providers can much more efficient develop relevant service catalogues with connected reporting services related to SLA's and KPI's based on ITIL and newer frameworks like SIAM....

  15. Leveraging the Publish-Find-Use Paradigm of SOA -- Supporting enterprise collaboration across organisational boundaries

    NARCIS (Netherlands)

    Sapkota, Brahmananda; van Sinderen, Marten J.; Shishkov, Boris

    Service Oriented Architecture (SOA) has been widely recognized as an approach for flexible integration of enterprise applications across organisational boundaries based on service abstractions and Internet standards. Enterprise collaboration and application integration is driven by business

  16. Architecture Approach in System Development

    Directory of Open Access Journals (Sweden)

    Ladislav Burita

    2017-01-01

    Full Text Available The purpose of this paper is to describe a practical solution of architecture approach in system development. The software application is the system which optimizes the transport service. The first part of the paper defines the enterprise architecture, its parts and frameworks. Next is explained the NATO Architecture Framework (NAF, a tool for command and control systems development in military environment. The NAF is used for architecture design of the system for optimization of the transport service.

  17. Malignant lymphoma of the conjunctiva

    DEFF Research Database (Denmark)

    Kirkegaard, Marina M.; Coupland, Sarah E.; Prause, Jan U.

    2015-01-01

    Conjunctival lymphomas constitute 25% of all ocular adnexal lymphomas. The majority are B-cell non-Hodgkin lymphomas (NHLs) (98%), whereas conjunctival T-cell NHLs are rare (2%). The most frequent subtype of conjunctival B-cell lymphoma is extranodal marginal zone lymphoma (EMZL; 81%), followed...... by follicular lymphoma (8%), diffuse large B-cell lymphoma (3%), and mantle cell lymphoma (3%). Extranodal marginal zone lymphoma occurs slightly more often in women and, along with follicular lymphoma, presents late in the seventh decade of life, whereas diffuse large B-cell lymphoma and especially mantle cell...... lymphoma have a predilection for the male gender and typically present in the eighth decade. Extranodal marginal zone lymphoma and follicular lymphoma present most frequently in the forniceal and bulbar conjunctiva. Conjunctival diffuse large B-cell lymphoma, mantle cell lymphoma and T-cell NHLs...

  18. Enterprise Computing

    OpenAIRE

    Spruth, Wilhelm G.

    2013-01-01

    Das vorliegende Buch entstand aus einer zweisemestrigen Vorlesung „Enterprise Computing“, die wir gemeinsam über viele Jahre als Teil des Bachelor- oder Master-Studienganges an der Universität Leipzig gehalten haben. Das Buch führt ein in die Welt des Mainframe und soll dem Leser einen einführenden Überblick geben. Band 1 ist der Einführung in z/OS gewidmet, während sich Band 2 mit der Internet Integration beschäftigt. Ergänzend werden in Band 3 praktische Übungen unter z/OS dargestellt....

  19. Editorial: Enterprise Participation (January 2009

    Directory of Open Access Journals (Sweden)

    Donald Smith

    2009-01-01

    Full Text Available In The Role of Participation Architecture in Growing Sponsored Open Source Communities, Joel West and Siobhan O'Mahony argue that "to some extent, firms and technical communities have always collaborated to create standards, shared infrastructure, and innovation outcomes that are bigger than any one firm can achieve." and that "there is increasing evidence that path breaking innovations cannot occur without a community to interpret, support, extend and diffuse them". When considered in this light, it should not be surprising that more enterprises, both large and small, are increasing their participation in open source communities to drive innovation. The theme for this month's issue of the OSBR is enterprise participation and the authors provide practical advice for effective enterprise/community collaboration. Their experiences provide perspectives on: i the Eclipse Foundation, which maintains an ecosystem of over 150 enterprises that participate in Eclipse open source projects; ii an independent software vendor that sells closed source solutions constructed on top of an open source platform to large enterprise customers; iii the impact of major players collaborating on a common open source platform for the mobile industry; iv the role users can play in the very large (over 14 million GNOME community; and v the lessons a scientist from the National Research Council of Canada learned when he released software and started a small open source community.

  20. Enterprise Social Networks

    DEFF Research Database (Denmark)

    Winkler, Till J.; Trier, Matthias

    2017-01-01

    Enterprise Social Networks (ESNs), d. h. Informationssysteme, die die Vernetzung von Mitarbeitern in Unternehmen fördern sollen, sind in verschiedenen Varianten und unter verschiedenen Bezeichnungen (etwa Enterprise Social Media, Corporate Social Software, Social Business oder Enterprise 2...

  1. The enterprise engineering domain

    CSIR Research Space (South Africa)

    De Vries, M

    2015-06-01

    Full Text Available Enterprise engineering (EE) is emerging as a new discipline to address the design of the enterprise in a holistic way. Although existing knowledge on enterprise design is dispersed and fragmented across different disciplines and approaches, previous...

  2. Sustainable Enterprise Excellence

    DEFF Research Database (Denmark)

    Edgeman, Rick; Williams, Joseph; Eskildsen, Jacob Kjær

    , supply chain, customer-related, human capital, financial, marketplace, societal, and environmental performance. Sustainable Enterprise Excellence integrates ethical, efficient and effective (E3) enterprise governance with 3E (equity, ecology, economy) Triple Top Line strategy throughout enterprise...

  3. Lymphoma of the Eyelid

    DEFF Research Database (Denmark)

    Svendsen, Frederik Holm; Rasmussen, Peter Kristian; Coupland, Sarah E.

    2017-01-01

    Purpose To document subtype-specific clinical features of lymphoma of the eyelid, and their effect on patient outcome. Design Retrospective observational case series. Methods Patient data were collected from 7 international eye cancer centers from January 1, 1980 through December 31, 2015....... The cases included primary and secondary lymphomas affecting the eyelid. Overall survival, disease-specific survival (DSS), and progression-free survival were the primary endpoints. Results Eighty-six patients were included. Mean age was 63 years and 47 (55%) were male. Non-Hodgkin B-cell lymphomas...... constituted 83% (n = 71) and T-cell lymphomas constituted 17% (n = 15). The most common subtypes were extranodal marginal-zone lymphoma (EMZL) (37% [n = 32]), follicular lymphoma (FL) (23% [n = 20]), diffuse large B-cell lymphoma (DLBCL) (10% [n = 9]), mantle cell lymphoma (MCL) (8% [n = 7]), and mycosis...

  4. International Lymphoma Epidemiology Consortium

    Science.gov (United States)

    The InterLymph Consortium, or formally the International Consortium of Investigators Working on Non-Hodgkin's Lymphoma Epidemiologic Studies, is an open scientific forum for epidemiologic research in non-Hodgkin's lymphoma.

  5. Radiotherapy of malignant lymphomas

    Energy Technology Data Exchange (ETDEWEB)

    Kujawska, J [Instytut Onkologii, Krakow (Poland)

    1979-01-01

    The paper discusses current views on the role of radiotherapy in the treatment of patients with malignant lymphomas. Principles of radiotherapy employed in the Institute of Oncology in Cracow in case of patients with malignant lymphomas are also presented.

  6. Control architectures for IT management

    International Nuclear Information System (INIS)

    Wang Ting

    2003-01-01

    This paper summaries the three financial control architectures for IT department in an enterprise or organization, they are unallocated cost center, allocated cost center and profit center, analyses the characteristics of them and in the end gives the detailed suggestions for choosing these control architectures. (authors)

  7. Is Enterprise Education Relevant to Social Enterprise?

    Science.gov (United States)

    Bridge, Simon

    2015-01-01

    Purpose: Both enterprise education and social enterprise have become fashionable but what, if any, should be the connections between them? The purpose of this paper is to explore those connections and to reflect on what relevance the two concepts might have for each other. Design/methodology/approach: Both enterprise education and social…

  8. Lymphoma Research Foundation

    Science.gov (United States)

    ... Follow LRF Watch LRF Contact Us National Headquarters Wall Street Plaza 88 Pine Street, Suite 2400 | New York, NY 10005 212-349-2910 | 212-349-2886 Fax LRF@lymphoma.org LRF Helpline 800-500-9976 Helpline@lymphoma.org © 2012 Lymphoma Research Foundation | Privacy Policy

  9. Architectural Refinement for the Design of Survivable Systems

    National Research Council Canada - National Science Library

    Ellison, Robert

    2001-01-01

    This paper describes a process for systematically refining an enterprise system architecture to resist recognize and recover from deliberate, malicious attacks by applying reusable design primitives...

  10. Radiology systems architecture.

    Science.gov (United States)

    Deibel, S R; Greenes, R A

    1996-05-01

    This article focuses on the software requirements for enterprise integration in radiology. The needs of a future radiology systems architecture are examined, both at a concrete functional level and at an abstract system-properties level. A component-based approach to software development is described and is validated in the context of each of the abstract system requirements for future radiology computing environments.

  11. VA Enterprise Design Patterns - 5.1 (Mobility) Mobile

    Data.gov (United States)

    Department of Veterans Affairs — First of a set of guidance documents that establish the architectural foundation for mobile computing in the VA. This document outlines the enterprise capabilities...

  12. ERP II: Next-generation Extended Enterprise Resource Planning

    DEFF Research Database (Denmark)

    Møller, Charles

    2004-01-01

    ERP II (ERP/2) systems is a new concept introduced by Gartner Group in 2000 in order to label the latest extensions of the ERP-systems. The purpose of this paper is to explore the next-generation of ERP systems, the Extended Enterprise Resource Planning (EERP or as we prefer to use: e...... impact on extended enterprise architecture.....

  13. ERP II - Next-generation Extended Enterprise Resource Planning

    DEFF Research Database (Denmark)

    Møller, Charles

    2003-01-01

    ERP II (ERP/2) systems is a new concept introduced by Gartner Group in 2000 in order to label the latest extensions of the ERP-systems. The purpose of this paper is to explore the next-generation of ERP systems, the Extended Enterprise Resource Planning (EERP or as we prefer to use: e...... impact on extended enterprise architecture....

  14. HP advances Grid Strategy for the adaptive enterprise

    CERN Multimedia

    2003-01-01

    "HP today announced plans to further enable its enterprise infrastructure technologies for grid computing. By leveraging open grid standards, HP plans to help customers simplify the use and management of distributed IT resources. The initiative will integrate industry grid standards, including the Globus Toolkit and Open Grid Services Architecture (OGSA), across HP's enterprise product lines" (1 page).

  15. Imaging of MALT lymphomas

    International Nuclear Information System (INIS)

    Rodallec, M.; Guermazi, A.; Attal, P.; Zagdanski, A.M.; Frija, J.; De Kerviler, E.; Brice, P.

    2002-01-01

    The broad category of non-Hodgkin's lymphoma includes a large variety of different diseases including indolent as well as aggressive lymphomas. Mucosa-associated lymphoid tissue (MALT) lymphoma arises in the extranodal mucosal lymphoid tissue and has only been recognised as a distinct entity in recent years. It affects one or several extranodal structures such as the stomach, the lung, the eye and salivary glands. The lymphoma is generally of low grade and has indolent course. The aim of this article is to exemplify the most common radiological patterns of MALT lymphoma. (orig.)

  16. Molecular diagnosis of Burkitt's lymphoma

    NARCIS (Netherlands)

    Dave, SS; Fu, K; Wright, GW; Lam, LT; Kluin, P; Boerma, EJ; Greiner, TC; Weisenburger, DD; Rosenwald, A; Ott, G; Muller-Hermelink, H; Gascoyne, RD; Delabie, J; Rimsza, LM; Braziel, RM; Grogan, TM; Campo, E; Jaffe, ES; Dave, BJ; Sanger, W; Bast, M; Vose, JM; Armitage, JO; Connors, JM; Smeland, EB; Kvaloy, S; Holte, H; Fisher, RI; Miller, TP; Montserrat, E; Wilson, WH; Bahl, M; Zhao, H; Yang, LM; Powell, J; Simon, R; Chan, WC; Staudt, LM

    2006-01-01

    Background: The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is crucial because these two types of lymphoma require different treatments. We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma.

  17. Effectively Managing the Air Force Enterprise Architecture

    Science.gov (United States)

    2005-01-18

    infrastructure, systems development, and strategic data planning. Denzin and Lincoln suggests that a content analysis is an acceptable research...methodology for this type of data ( Denzin and Lincoln , 2000). Leedy and Ormrod agree that a content analysis is the systematic examination of written...2003). Advances in Mixed Method Design. Thousand Oaks, CA, Sage. Denzin , N. K. and Y. S. Lincoln (2000). Handbook of Qualitative Research

  18. Modeling value creation with enterprise architecture

    NARCIS (Netherlands)

    Singh, Prince Mayurank; Jonkers, H.; Iacob, Maria Eugenia; van Sinderen, Marten J.

    2014-01-01

    Firms may not succeed in business if strategies are not properly implemented in practice. Every firm needs to know, represent and master its value creation logic, not only to stay in business but also to keep growing. This paper is about focusing on an important topic in the field of strategic

  19. Molecular resemblance of an AIDS-associated lymphoma and endemic Burkitt lymphomas: Implications for their pathogenesis

    International Nuclear Information System (INIS)

    Haluska, F.G.; Russo, G.; Croce, C.M.; Kant, J.; Andreef, M.

    1989-01-01

    Non-Hodgkin lymphoma is a common feature of AIDS. Approximately 30-40% of these tumors exhibit clinical features suggestive of endemic Burkitt lymphoma: they are aggressive malignancies that occur in association with Epstein-Barr virus infection, they arise in the setting of immunosuppression, and they carry t(8;14) translocations without detectable rearrangement of the MYC oncogene. To understand the molecular basis of these parallels, the authors analyzed a case of Epstein-Barr-positive AIDS-associated undifferentiated lymphoma. Southern blots show that the tumor exhibits immunoglobulin joining segment rearrangement but no rearrangement of the MYC oncogene. Cloning of the rearranged joining segment allowed the isolation of recombinant clones encompassing the translocation breakpoint, and sequencing of the translocation junction disclosed that the breakpoint is situated 7 base pairs from the chromosome 14 site involved in a previously described endemic Burkitt lymphoma translocation. Furthermore, the breakpoint is situated far from MYC on chromosome 8, a constant finding in endemic Burkitt lymphomas. That the molecular architecture of the translocation in this case is strikingly similar to previously analyzed translocations from endemic Burkitt lymphomas strongly suggests that common molecular mechanisms must be operative in the pathogenesis of these tumors

  20. Technical Limits of ICT for Enterprises' Innovations

    Directory of Open Access Journals (Sweden)

    Radim Brixi

    2012-01-01

    Full Text Available The paper deals with technical limits of ICT for enterprises' innovations. ICT is now a key asset for the competitiveness of enterprises. It became the main stream of doing business well. These days we come to era where enterprises are fully dependant on ICT. We would try to describe more deeply the impacts of such a dependence and underlying problems. In context of the necessary new innovations of enterprises, we will focus more on the negative aspects of being dependent on ICT with the technological architecture of hard systems. Based on the need to apply a systems approach we will also provide a suggestion as to how to model these limits in a system's manner.

  1. Adult T-Cell Leukemia/Lymphoma

    Science.gov (United States)

    ... Non-Hodgkin Lymphoma Peripheral T-Cell Lymphoma Primary Central Nervous System Lymphoma T-Cell Lymphoma Transformed Mycosis Fungoides Waldenstrom Macroglobulinemia Young Adult Lymphoma Overview Treatment Options Relapsed/Refractory Long-term ...

  2. Domain-specific languages for enterprise systems

    DEFF Research Database (Denmark)

    Andersen, Jesper; Bahr, Patrick; Henglein, Fritz

    2014-01-01

    The process-oriented event-driven transaction systems (POETS) architecture introduced by Henglein et al. is a novel software architecture for enterprise resource planning (ERP) systems. POETS employs a pragmatic separation between (i) transactional data, that is, what has happened; (ii) reports...... auditability; and support for referable data that may evolve over time, also while retaining full auditability as well as referential integrity. Besides the revised architecture, we present the DSLs used to specify data definitions, reports, and contracts respectively. Finally, we illustrate a use case...

  3. Mantle-cell lymphoma.

    Science.gov (United States)

    Barista, I; Romaguera, J E; Cabanillas, F

    2001-03-01

    During the past decade, mantle-cell lymphoma has been established as a new disease entity. The normal counterparts of the cells forming this malignant lymphoma are found in the mantle zone of the lymph node, a thin layer surrounding the germinal follicles. These cells have small to medium-sized nuclei, are commonly indented or cleaved, and stain positively with CD5, CD20, cyclin D1, and FMC7 antibodies. Because of its morphological appearance and a resemblance to other low-grade lymphomas, many of which grow slowly, this lymphoma was initially thought to be an indolent tumour, but its natural course was not thoroughly investigated until the 1990s, when the BCL1 oncogene was identified as a marker for this disease. Mantle-cell lymphoma is a discrete entity, unrelated to small lymphocytic or small-cleaved-cell lymphomas.

  4. A Systems Engineering Approach to Architecture Development

    Science.gov (United States)

    Di Pietro, David A.

    2015-01-01

    Architecture development is often conducted prior to system concept design when there is a need to determine the best-value mix of systems that works collectively in specific scenarios and time frames to accomplish a set of mission area objectives. While multiple architecture frameworks exist, they often require use of unique taxonomies and data structures. In contrast, this paper characterizes architecture development using terminology widely understood within the systems engineering community. Using a notional civil space architecture example, it employs a multi-tier framework to describe the enterprise level architecture and illustrates how results of lower tier, mission area architectures integrate into the enterprise architecture. It also presents practices for conducting effective mission area architecture studies, including establishing the trade space, developing functions and metrics, evaluating the ability of potential design solutions to meet the required functions, and expediting study execution through the use of iterative design cycles

  5. Use of GERAM as Basis for a Virtual Enterprise Framework Model

    DEFF Research Database (Denmark)

    Vesterager, Johan; Bernus, Peter; Larsen, Lars B

    2001-01-01

    In the IMS-project Globeman21, the enterprise reference architecture GERAM was used as basis for creation of a virtual enterprise framework model. The model was used to map different industrial pilot projects, to classify virtual en-terprise concepts, and as underlying structure for a virtual...... enterprise manage-ment methodology. The paper gives a survey of the use of GERAM and the re-sults obtained....

  6. Lesotho - Enterprise Survey

    Data.gov (United States)

    Millennium Challenge Corporation — The 2011 MCA-Lesotho baseline enterprise survey is a national survey of enterprises. The main objective of the survey was to assess the current status of businesses...

  7. Extended Enterprise performance Management

    NARCIS (Netherlands)

    Bobbink, Maria Lammerdina; Hartmann, Andreas

    2014-01-01

    The allegiance of partnering organisations and their employees to an Extended Enterprise performance is its proverbial sword of Damocles. Literature on Extended Enterprises focuses on collaboration, inter-organizational integration and learning to avoid diminishing or missing allegiance becoming an

  8. Inquiry and Enterprise Transformation

    Science.gov (United States)

    Bonney, Dean J.

    What really constitutes an Enterprise from an Enterprise Systems Engineering perspective? My effort to create a workable definition follows: An Enterprise is a complex system of community, individual, and semiotic systems defined by the way its authentic relationships are constructed and dependent on the ways the parties to these relationships bind to one another. The imprint of an Enterprise is projected through its spatial identity, an identity that builds and maintains its currency through the positive images and authentic relationships it embraces.

  9. Enterprise, Entrepreneurship and Ethics

    DEFF Research Database (Denmark)

    Hjorth, Daniel; Holt, Robin

    In the wake of calls for enterprise-led recovery amid Western economies, we critically investigate the enterprise discourse. Specifically, we challenge the association of enterprise and entrepreneurial activity. Using Foucault’s concept of parrrhesia - an ethical condition of brave speech - we ar...

  10. VEM: Virtual Enterprise Methodology

    DEFF Research Database (Denmark)

    Tølle, Martin; Vesterager, Johan

    2003-01-01

    This chapter presents a virtual enterprise methodology (VEM) that outlines activities to consider when setting up and managing virtual enterprises (VEs). As a methodology the VEM helps companies to ask the right questions when preparing for and setting up an enterprise network, which works...

  11. Primary malignant intramedullary lymphoma

    International Nuclear Information System (INIS)

    Orrego P, E.; Heinicke Y, H.; Arbaiza A, D.; Yepez R, V.

    1999-01-01

    A case of primary malignant intramedullary lymphoma, localized in the dorsal part of the spinal cord is presented. The clinical symptoms were associated with motor and sensitive deficit. Clinical investigations excluded the presence of lymphoma in other locations in the central nervous system and the extra neural organs. Postoperative radiotherapy and chemotherapy improved relict neurological symptoms. (authors)

  12. PET CT and lymphomas

    International Nuclear Information System (INIS)

    Castro, R.

    2012-01-01

    This presentation is about Tc and lymphomas. Classification and clinical cases of various cancer such as gastro duodenal or ulcer, mama, medullary, lymph and neck, leukemia, nodular sclerosis. Metabolic information, anatomical nature of lymphoma and its clinical presentation determine the extent that PET should be used in the patient.

  13. Hodgkin Lymphoma (For Kids)

    Science.gov (United States)

    ... First Aid & Safety Doctors & Hospitals Videos Recipes for Kids Kids site Sitio para niños How the Body Works ... Educators Search English Español Hodgkin Lymphoma KidsHealth / For Kids / Hodgkin Lymphoma What's in this article? What Is ...

  14. Process and data fragmentation-oriented enterprise network integration with collaboration modelling and collaboration agents

    Science.gov (United States)

    Li, Qing; Wang, Ze-yuan; Cao, Zhi-chao; Du, Rui-yang; Luo, Hao

    2015-08-01

    With the process of globalisation and the development of management models and information technology, enterprise cooperation and collaboration has developed from intra-enterprise integration, outsourcing and inter-enterprise integration, and supply chain management, to virtual enterprises and enterprise networks. Some midfielder enterprises begin to serve for different supply chains. Therefore, they combine related supply chains into a complex enterprise network. The main challenges for enterprise network's integration and collaboration are business process and data fragmentation beyond organisational boundaries. This paper reviews the requirements of enterprise network's integration and collaboration, as well as the development of new information technologies. Based on service-oriented architecture (SOA), collaboration modelling and collaboration agents are introduced to solve problems of collaborative management for service convergence under the condition of process and data fragmentation. A model-driven methodology is developed to design and deploy the integrating framework. An industrial experiment is designed and implemented to illustrate the usage of developed technologies in this paper.

  15. [Secondary orbital lymphoma].

    Science.gov (United States)

    Basanta, I; Sevillano, C; Álvarez, M D

    2015-09-01

    A case is presented of an 85 year-old Caucasian female with lymphoma that recurred in the orbit (secondary ocular adnexal lymphoma). The orbital tumour was a diffuse large B-cell lymphoma according to the REAL classification (Revised European-American Lymphoma Classification). Orbital lymphomas are predominantly B-cell proliferations of a variety of histological types, and most are low-grade tumours. Patients are usually middle-aged or elderly, and it is slightly more common in women. A palpable mass, proptosis and blepharoptosis are the most common signs of presentation. Copyright © 2011 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.

  16. CARDIAC LYMPHOMA IN DOG

    Directory of Open Access Journals (Sweden)

    G. D. Cruz

    2016-11-01

    Full Text Available Lymphoma is a lymphoid tumor that originates in hematopoietic organs such as lymph node, spleen or liver. In dogs, the overall prevalence of cardiac tumors was estimated to be only 0.19% based on the results of the survey of a large database, and lymphomas accounts for approximately 2% of all cardiac tumors. In general, the involvement of the myocardium is rarely described in canine lymphoma. Currently, there is no evidence of a viral association with primary cardiac lymphoma in dogs, but other types of immunosuppression may contribute to abnormal events, such as involvement primary cardiac. The aim of this study was to analyze a case of sudden death of a bitch, SRD, aged 10, who had the final diagnosis of cardiac lymphoma.

  17. Extranodal diffuse non hodgkin lymphoma in the thigh

    Directory of Open Access Journals (Sweden)

    Bölke E

    2010-08-01

    Full Text Available Abstract Diffuse large B-cell lymphoma usually starts as a rapidly growing mass in an internal lymph node and can grow in other areas such as the bone or intestines. About 1/3 of these lymphomas are confined to one part of the body when they are localized. In the case of a 78-year-old man, an extensive tumour was located on the right thigh. Biopsies of the tumour revealed diffuse proliferation of large lymphoid cells which have totally affected the normal architecture of striated muscle. The patient received multimodality treatment including chemotherapy of the CHOP regimen and adjuvant radiotherapy. Despite this being a fast growing lymphoma, about 3 out of 4 people will have no signs of disease after initial treatment, and about half of all people with this lymphoma are cured with therapy.

  18. A Framework for Enterprise Operating Systems Based on Zachman Framework

    Science.gov (United States)

    Ostadzadeh, S. Shervin; Rahmani, Amir Masoud

    Nowadays, the Operating System (OS) isn't only the software that runs your computer. In the typical information-driven organization, the operating system is part of a much larger platform for applications and data that extends across the LAN, WAN and Internet. An OS cannot be an island unto itself; it must work with the rest of the enterprise. Enterprise wide applications require an Enterprise Operating System (EOS). Enterprise operating systems used in an enterprise have brought about an inevitable tendency to lunge towards organizing their information activities in a comprehensive way. In this respect, Enterprise Architecture (EA) has proven to be the leading option for development and maintenance of enterprise operating systems. EA clearly provides a thorough outline of the whole information system comprising an enterprise. To establish such an outline, a logical framework needs to be laid upon the entire information system. Zachman Framework (ZF) has been widely accepted as a standard scheme for identifying and organizing descriptive representations that have prominent roles in enterprise-wide system development. In this paper, we propose a framework based on ZF for enterprise operating systems. The presented framework helps developers to design and justify completely integrated business, IT systems, and operating systems which results in improved project success rate.

  19. A method for valuing architecture-based business transformation and measuring the value of solutions architecture

    NARCIS (Netherlands)

    Slot, R.G.

    2010-01-01

    Enterprise and Solution Architecture are key in today’s business environment. It is surprising that the foundation and business case for these activities are nonexistent; the financial value for the business of these activities is largely undetermined. To determine business value of enterprise and

  20. Architectural prototyping

    DEFF Research Database (Denmark)

    Bardram, Jakob Eyvind; Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2004-01-01

    A major part of software architecture design is learning how specific architectural designs balance the concerns of stakeholders. We explore the notion of "architectural prototypes", correspondingly architectural prototyping, as a means of using executable prototypes to investigate stakeholders...

  1. Pembrolizumab and Vorinostat in Treating Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma, Follicular Lymphoma, or Hodgkin Lymphoma

    Science.gov (United States)

    2018-04-23

    Grade 3a Follicular Lymphoma; Grade 3b Follicular Lymphoma; Recurrent Classical Hodgkin Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Follicular Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Mediastinal (Thymic) Large B-Cell Cell Lymphoma; Refractory Classical Hodgkin Lymphoma; Refractory Diffuse Large B-Cell Lymphoma; Refractory Follicular Lymphoma; Refractory Mediastinal (Thymic) Large B-Cell Cell Lymphoma

  2. Ocular Adnexal Follicular Lymphoma

    DEFF Research Database (Denmark)

    Rasmussen, Peter K; Coupland, Sarah E; Finger, Paul T

    2014-01-01

    that involved 6 eye cancer centers from January 1, 1980, through December 31, 2010. A total of 105 patients with follicular OAL were identified, of which 7 patients were excluded because of missing clinical data. The median follow-up time was 52 months (range, 13-118 months). MAIN OUTCOMES AND MEASURES Overall...... in conjunction with a concurrent systemic lymphoma, and 10 (10%) presented with an ocular adnexal relapse. The lacrimal gland (28%), conjunctiva (28%), and orbit (28%) were the most frequently involved sites. Of the 69 patients with primary follicular lymphoma, 38 (55%) presented with Ann Arbor stage IE lymphoma...

  3. Multi-Criteria Decision Analysis Framework in the Selection of an Enterprise Integration (EI) Approach That Best Satisfies Organizational Requirements

    Science.gov (United States)

    Ngeru, James

    2012-01-01

    In the past few decades, adoption of Enterprise Integration (EI) through initiatives such as Service Oriented Architecture (SOA), Enterprise Application Integration (EAI) and Enterprise Resource Planning (ERP) has consistently dominated most of organizations' top strategic priorities. Additionally, the field of EI has generated a vast amount…

  4. Architecture on Architecture

    DEFF Research Database (Denmark)

    Olesen, Karen

    2016-01-01

    that is not scientific or academic but is more like a latent body of data that we find embedded in existing works of architecture. This information, it is argued, is not limited by the historical context of the work. It can be thought of as a virtual capacity – a reservoir of spatial configurations that can...... correlation between the study of existing architectures and the training of competences to design for present-day realities.......This paper will discuss the challenges faced by architectural education today. It takes as its starting point the double commitment of any school of architecture: on the one hand the task of preserving the particular knowledge that belongs to the discipline of architecture, and on the other hand...

  5. Enterprise Application Integration Using Java Technologies

    Directory of Open Access Journals (Sweden)

    Alexandru BARBULESCU

    2006-01-01

    Full Text Available The current article points out some of the tasks and challenges companies must face in order to integrate their computerized systems and applications and then to place them on the Web. Also, the article shows how the Java 2 Enterprise Edition Platform and architecture helps the Web integration of applications. By offering standardized integration contracts, J2EE Platform allows application servers to play a key role in the process of Web integration of the applications.

  6. Industrial Cloud: Toward Inter-enterprise Integration

    Science.gov (United States)

    Wlodarczyk, Tomasz Wiktor; Rong, Chunming; Thorsen, Kari Anne Haaland

    Industrial cloud is introduced as a new inter-enterprise integration concept in cloud computing. The characteristics of an industrial cloud are given by its definition and architecture and compared with other general cloud concepts. The concept is then demonstrated by a practical use case, based on Integrated Operations (IO) in the Norwegian Continental Shelf (NCS), showing how industrial digital information integration platform gives competitive advantage to the companies involved. Further research and development challenges are also discussed.

  7. Danish National Lymphoma Registry

    DEFF Research Database (Denmark)

    Arboe, Bente; Josefsson, Pär; Jørgensen, Judit

    2016-01-01

    AIM OF DATABASE: The Danish National Lymphoma Registry (LYFO) was established in order to monitor and improve the diagnostic evaluation and the quality of treatment of all lymphoma patients in Denmark. STUDY POPULATION: The LYFO database was established in 1982 as a seminational database including...... all lymphoma patients referred to the departments of hematology. The database became nationwide on January 1, 2000. MAIN VARIABLES: The main variables include both clinical and paraclinical variables as well as details of treatment and treatment evaluation. Up to four forms are completed for each......-100 years) and a male/female ratio of 1.23:1. Patients can be registered with any of 42 different subtypes according to the World Health Organization classifications. CONCLUSION: LYFO is a nationwide database for all lymphoma patients in Denmark and includes detailed information. This information is used...

  8. Non-Hodgkin's lymphomas

    International Nuclear Information System (INIS)

    Glatstein, E.; Wasserman, T.H.

    1987-01-01

    Non-Hodgkin's lymphomas are a varied and complex group of diseases that must be distinguished from Hodgkin's disease. The latter almost always begins in lymph nodes and spreads primarily in an axial fashion; non-Hodgkin's lymphomas may begin either in lymph nodes or in extranodal tissue and can spread both in an axial fashion and centrifugally. Because of changes in pathology terminology and the introduction of a classification using cell surface markers, many prognostic groups of patients with lymphomas have evolved. Therapeutic choices and prognosis are greatly influenced by variations in anatomic sites and extent of disease. Currently, the decisions on management require a balancing of radiation therapy with systemic chemotherapy. In some cases, radiation therapy alone may be sufficient; however, because most patients with non-Hodgkins's lymphomas tend to have advanced disease, a large percentage of patients will be managed with chemotherapy alone or in combination with radiation therapy

  9. The challenge of networked enterprises for cloud computing interoperability

    OpenAIRE

    Mezgár, István; Rauschecker, Ursula

    2014-01-01

    Manufacturing enterprises have to organize themselves into effective system architectures forming different types of Networked Enterprises (NE) to match fast changing market demands. Cloud Computing (CC) is an important up to date computing concept for NE, as it offers significant financial and technical advantages beside high-level collaboration possibilities. As cloud computing is a new concept the solutions for handling interoperability, portability, security, privacy and standardization c...

  10. Governing for Enterprise Security

    National Research Council Canada - National Science Library

    Allen, Julia

    2005-01-01

    ... business. If an organization's management -- including boards of directors, senior executives, and all managers -- does not establish and reinforce the business need for effective enterprise security...

  11. Towards a Service-Oriented Enterprise: The Design of a Cloud Business Integration Platform in a Medium-Sized Manufacturing Enterprise

    Science.gov (United States)

    Stamas, Paul J.

    2013-01-01

    This case study research followed the two-year transition of a medium-sized manufacturing firm towards a service-oriented enterprise. A service-oriented enterprise is an emerging architecture of the firm that leverages the paradigm of services computing to integrate the capabilities of the firm with the complementary competencies of business…

  12. THE ROLE OF ENTERPRISE PORTALS IN ENTERPRISE INTEGRATION

    Directory of Open Access Journals (Sweden)

    Gianina RIZESCU

    2006-01-01

    Full Text Available Today’s enterprises are moving business systems to the Internet - to connect people, business processes, and people to business processes in enterprise and across enterprise boundaries. The portal brings it all together: business processes, departmental sites, knowledge management resources, enterprise management systems, CRM systems, analytics, email, calendars, external content, transactions,administration, workflow, and more. The goal of this paper is to present the role of the Enterprise Portal in internal and external enterprise integration.

  13. Enterprise applications administration the definitive guide to implementation and operations

    CERN Document Server

    Faircloth, Jeremy

    2014-01-01

    Enterprise Applications Administration prepares you for the full breadth of work associated with administering large enterprise applications. This book provides essential information on tasks such as operating systems administration, network design, system architecture, project planning, working within a team, protecting the network, and how to keep applications up and running. The book effectively bridges the gap between what is taught in the technology-specific literature and the real world of enterprise application administrators.Provides a general understanding of all key knowledge areas n

  14. Enterprise Education as Pedagogy

    Science.gov (United States)

    Jones, Brian; Iredale, Norma

    2010-01-01

    Purpose: This paper seeks to suggest that the most appropriate way to construe the concept of enterprise education is from a pedagogical viewpoint. Enterprise education as pedagogy is argued to be the most appropriate way to think about the concept and serves to demarcate it from entrepreneurship education, which is very much about business…

  15. It's Entrepreneurship, not Enterprise

    DEFF Research Database (Denmark)

    Hjorth, Daniel; Holt, Robin

    2016-01-01

    We challenge the obvious and easy association of enterprise and entrepreneurship. We do so by arguing that entrepreneurship is inherently social and collective, something that is concealed when held up as example of enterprising behaviour. We use as an illustrative case the Chinese artist Ai Weiwei...

  16. Survey of Micro Enterprise.

    Science.gov (United States)

    European Social Fund, Dublin (Ireland).

    Government support of microenterprise/entrepreneurship in Ireland was examined through structured interviews with 81 of 120 microentrepreneurs (68% response rate) identified as clients of local enterprise support agencies and/or completers of enterprise training and structured interviews with representatives of 25 local, voluntary, and private…

  17. RESTRUCTURING OF INDUSTRIAL ENTERPRISE

    Directory of Open Access Journals (Sweden)

    L. I. Podderegina

    2009-01-01

    Full Text Available The paper presents main principles for execution of current and strategic restructuring of national enterprises while using experience of countries with developed market economy. The principles contribute to higher efficiency in internal industrial relations at national industrial enterprises.

  18. Stages of Adult Hodgkin Lymphoma

    Science.gov (United States)

    ... Lymphocyte-rich classical Hodgkin lymphoma. Age, gender, and Epstein-Barr infection can affect the risk of adult Hodgkin lymphoma. Anything that increases your risk of getting a disease is called a risk factor . Having a risk ...

  19. Stages of Childhood Hodgkin Lymphoma

    Science.gov (United States)

    ... Version Key Points Childhood Hodgkin lymphoma is a disease in which malignant (cancer) cells form in the lymph system. There are two types of childhood Hodgkin lymphoma. Epstein-Barr virus infection increases the risk of childhood Hodgkin ...

  20. The Danish National Lymphoma Registry

    DEFF Research Database (Denmark)

    Arboe, Bente; El-Galaly, Tarec Christoffer; Clausen, Michael Roost

    2016-01-01

    BACKGROUND: The Danish National Lymphoma Register (LYFO) prospectively includes information on all lymphoma patients newly diagnosed at hematology departments in Denmark. The validity of the clinical information in the LYFO has never been systematically assessed. AIM: To test the coverage and data...... of 3% (N = 364) was made from all patients in the LYFO. In addition, four subtypes of lymphomas were validated: CNS lymphomas, diffuse large B-cell lymphomas, peripheral T-cell lymphomas, and Hodgkin lymphomas. A total of 1,706 patients from the period 2000-2012 were included. The positive predictive...... was good with high PPVs (87% to 100%), and high completeness (92% to 100%). CONCLUSION: The LYFO is a unique, nationwide clinical database characterized by high validity, good coverage and prospective data entry. It represents a valuable resource for future lymphoma research....

  1. Nodular breast lymphoma

    International Nuclear Information System (INIS)

    Rodriguez, M.; Sahagun, E.; Pena, J.; Mendez, J.

    1996-01-01

    We attempt to correlate the histological types [in three cases of B-cell non-Hodgkin's lymphoma (NHL), one case of T-cell NHL and one of Hodgkin's disease] with the radiological presentation and compare our findings with the literature reviewed. Among the mammographic studies, performed over and 18-month period, we have assessed five patients (four women and one man, aged as having lymphoma. the man presented bilateral involvement. Both mammography and a broader study with ultrasound and chest and abdominal CT scan were performed in every case. Four patients underwent breast ultrasound. The definitive diagnosis was based on biopsy in all cases. Three of the five cases involved primary lymphomas and the other two were secondary. Four patients presented NHL and the remaining patient had Hodgkin's disease. In mammography, the nodules showed different degrees of margin definition. In ultrasound, all the lesion were hypoechoic. The radiological diagnosis of breast lymphoma is difficult in the absence of a previous diagnosis of lymphoma. This lesion should be included in the differential diagnosis in the presence of a breast nodule associated with axillary lymph nodes, especially when the latter are bilateral. (Author)

  2. Classification of malignant lymphomas

    International Nuclear Information System (INIS)

    Schneider, M.; Thyss, A.

    1986-01-01

    Malignant lymphomas, primary tumors of the lymphoid tissues, were first described in 1832 by Thomas Hodgkin. The histological characteristics were later defined by Sternberg and Reed, and Virchow introduced the concept of lymphosarcoma in 1863. Today, these pathologies are grouped together under the synonymous terms hematosarcoma or malignant lymphoma, which are in turn divided into Hodgkin's disease (HD) and non-Hodgkin's malignant lymphomas (NHL). The therapy of lymphomas is controversial. The validity of treatment for asymptomatic patients is questioned, owing to the indolent course of many lymphomas. Results for histologically unfavorable forms are highly disparate. Exclusive radiotherapy has occasionally produced up to 78% disease-free survival at 5 years for truly localized stages. Today, however, use of chemotherapy/radiotherapy combinations is almost universal, with chemotherapy occasionally being used alone and providing 90% disease-free survival at 5 years. Chemotherapy is the main treatment for disseminated forms; the major associations include doxorubicin hydrochloride (Adriamycin), cyclophosphamide, vincristine sulfate, methotrexate, and prednisone. Radiotherapy is used more for adjuvant purposes. Synthesis of recent studies allows us to reasonably expect 40% relapse-free survival at 10 years and the establishment of a cure plateau in the near future

  3. Immunohistochemical Characterization of Canine Lymphomas

    Directory of Open Access Journals (Sweden)

    Roxana CORA

    2017-11-01

    Full Text Available Lymphomas occur by clonal expansion of lymphoid cells and have distinctive morphological and immunophenotypic features. Determination of canine lymphoma immunophenotype is useful for accurate prognosis and further therapy. In the suggested study, we performed an immunohistochemical evaluation of some cases with canine lymphoma diagnosed in the Department of Pathology (Faculty of Veterinary Medicine, Cluj-Napoca, Romania, in order to characterize them. The investigation included 39 dogs diagnosed with different anatomical forms of lymphoma, following necropsy analysis or assessment of biopsies. The diagnosis of lymphoma was confirmed by necropsy and histopathology (Hematoxylin-eosin stain examinations. The collected specimens were analyzed by immunohistochemistry technique (automatic method using the following antibodies: CD3, CD20, CD21 and CD79a. The analyzed neoplasms were characterized as follows: about 64.10% of cases were diagnosed as B-cell lymphomas, 33.34% of cases as T-cell lymphomas, whereas 2.56% of cases were null cell type lymphomas (neither B nor T. Most of multicentric (80%, mediastinal (60% and primary central nervous system lymphomas (100% had B immunophenotype, while the majority of cutaneous (80% and digestive (100% lymphomas had T immunophenotype. Immunohistochemical description of canine lymphomas can deliver some major details concerning their behavior and malignancy. Additionally, vital prognosis and efficacy of some therapeutic protocols are relying on the immunohistochemical features of canine lymphoma.

  4. General certification procedure of enterprises and interim job enterprises

    CERN Document Server

    Int. At. Energy Agency, Wien

    2002-01-01

    This procedure defines the certification global process of enterprises employing workers of A or B category for nuclear facilities and interim job enterprises proposing workers of A or B category for nuclear facilities. This certification proves the enterprises ability to satisfy the specification ''E'' of the CEFRI and the interim job enterprises to satisfy the specification ''I'' of the CEFRI. (A.L.B.)

  5. Tax Planning for Enterprises

    Institute of Scientific and Technical Information of China (English)

    Fan Weiqing

    2011-01-01

    @@ Tax planning is legal planning activities for tax savings, meaning tax payers make operation plans within the national policy framework and choose operation programs favorable to tax savings.Along with a maturing socialist market economy system in China, tax planning is becoming an integral part of enterprise management and operation.For a better tax planning, enterprises have to fully understand the meaning, get proficient at relevant strategies, and apply these methods to save taxes and realize the maximization of enterprise value while considering the actual situation.

  6. The Energy Efficient Enterprise

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, Bashir

    2010-09-15

    Since rising energy costs have become a crucial factor for the economy of production processes, the optimization of energy efficiency is of essential importance for industrial enterprises. Enterprises establish energy saving programs, specific to their needs. The most important elements of these energy efficiency programs are energy savings, energy controlling, energy optimization, and energy management. This article highlights the industrial enterprise approach to establish sustainable energy management programs based on the above elements. Globally, if organizations follow this approach, they can significantly reduce the overall energy consumption and cost.

  7. The Extended Enterprise concept

    DEFF Research Database (Denmark)

    Larsen, Lars Bjørn; Vesterager, Johan; Gobbi, Chiara

    1999-01-01

    This paper provides an overview of the work that has been done regarding the Extended Enterprise concept in the Common Concept team of Globeman 21 including references to results deliverables concerning the development of the Extended Enterprise concept. The first section presents the basic concept...... picture from Globeman21, which illustrates the Globeman21 way of realising the Extended Enterprise concept. The second section presents the Globeman21 EE concept in a life cycle perspective, which to a large extent is based on the thoughts and ideas behind GERAM (ISO/DIS 15704)....

  8. JUNOS Enterprise Switching

    CERN Document Server

    Reynolds, Harry

    2009-01-01

    JUNOS Enterprise Switching is the only detailed technical book on Juniper Networks' new Ethernet-switching EX product platform. With this book, you'll learn all about the hardware and ASIC design prowess of the EX platform, as well as the JUNOS Software that powers it. Not only is this extremely practical book a useful, hands-on manual to the EX platform, it also makes an excellent study guide for certification exams in the JNTCP enterprise tracks. The authors have based JUNOS Enterprise Switching on their own Juniper training practices and programs, as well as the configuration, maintenanc

  9. Towards a Technique for Extracting Microservices from Monolithic Enterprise Systems

    OpenAIRE

    Levcovitz, Alessandra; Terra, Ricardo; Valente, Marco Tulio

    2016-01-01

    The idea behind microservices architecture is to develop a single large, complex application as a suite of small, cohesive, independent services. On the other way, monolithic systems get larger over the time, deviating from the intended architecture, and becoming risky and expensive to evolve. This paper describes a technique to identify and define microservices on monolithic enterprise systems. As the major contribution, our evaluation shows that our approach was able to identify relevant ca...

  10. Transformation of Follicular Lymphoma

    Science.gov (United States)

    Lossos, Izidore S.; Gascoyne, Randy D.

    2011-01-01

    Histological transformation of follicular lymphoma (FL) to a more aggressive non-Hodgkin's lymphomas is a pivotal event in the natural history of FL and is associated with poor outcome. While commonly observed in clinical practice and despite multiple studies designed to address its pathogenesis, the biology of this process represents an enigma. In this chapter we present a state of the art review summarizing the definition of histologic transformation, its incidence, pathogenesis, clinical manifestations, treatment and outcome. Furthermore, we specifically emphasize gaps in our knowledge that should be addressed in future studies. PMID:21658615

  11. Lymphoma of the Cervix

    Directory of Open Access Journals (Sweden)

    Juanita Parnis

    2012-01-01

    Full Text Available Primary non-Hodgkins lymphoma of the uterine cervix is a very rare diagnosis. A 54-year-old woman presented with a 3-month history of postmenopausal bleeding per vaginum. On examination, a friable, fungating lesion was seen on the cervix. Histology revealed a CD 20 positive high-grade non-Hodgkin’s diffuse large B cell lymphoma from cervical biopsies and endometrial curettage. She was diagnosed as stage IE after workup and subsequently treated with six cycles of R-CHOP chemotherapy followed by radiotherapy of the involved field.

  12. THE ROLE OF ENTERPRISE PORTALS IN ENTERPRISE INTEGRATION

    OpenAIRE

    Gianina RIZESCU

    2006-01-01

    Today’s enterprises are moving business systems to the Internet - to connect people, business processes, and people to business processes in enterprise and across enterprise boundaries. The portal brings it all together: business processes, departmental sites, knowledge management resources, enterprise management systems, CRM systems, analytics, email, calendars, external content, transactions, administration, workflow, and more. The goal of this paper is to present the role of the Enterprise...

  13. Architectural slicing

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2013-01-01

    Architectural prototyping is a widely used practice, con- cerned with taking architectural decisions through experiments with light- weight implementations. However, many architectural decisions are only taken when systems are already (partially) implemented. This is prob- lematic in the context...... of architectural prototyping since experiments with full systems are complex and expensive and thus architectural learn- ing is hindered. In this paper, we propose a novel technique for harvest- ing architectural prototypes from existing systems, \\architectural slic- ing", based on dynamic program slicing. Given...... a system and a slicing criterion, architectural slicing produces an architectural prototype that contain the elements in the architecture that are dependent on the ele- ments in the slicing criterion. Furthermore, we present an initial design and implementation of an architectural slicer for Java....

  14. The Scientific Enterprise

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 13; Issue 9. The Scientific Enterprise - Assumptions, Problems, and Goals in the Modern Scientific Framework. V V Raman. Reflections Volume 13 Issue 9 September 2008 pp 885-894 ...

  15. ASKME Enterprise Portal (internal) -

    Data.gov (United States)

    Department of Transportation — The ASKME Enterprise Portal Internal (AEPi) is envisioned to be an integrated, single-point-of-entry solution that contains modular components. The AEPi will provide...

  16. Lean Enterprise Value Phase

    National Research Council Canada - National Science Library

    Shields, John T

    2005-01-01

    ... using a philosophy called "lean." LAl's mission is to research, develop, and promulgate practices, tools, and knowledge that enable and accelerate the envisioned transformation of the greater US aerospace enterprise through people and processes...

  17. VA Enterprise Data Inventory

    Data.gov (United States)

    Department of Veterans Affairs — The Department of Veterans Affairs Enterprise Data Inventory accounts for all of the datasets used in the agency's information systems. This entry was approved for...

  18. HHS Enterprise Data Inventory

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Enterprise Data Inventory (EDI) is the comprehensive inventory listing of agency data resources including public, restricted public, and non-public datasets.

  19. Sustainable Enterprise Excellence

    DEFF Research Database (Denmark)

    Edgeman, Rick

    2013-01-01

    Structured Abstract Purpose: Sustainable Enterprise Excellence (SEE) is defined and developed through integration and expansion of business excellence modeling and sustainability thought. The intent is to enable simple yet reliable enterprise assessment of triple bottom line (TBL) performance...... and produce actionable enterprise foresight that can enable next best practices and sources of sustainable competitive advantage through innovation. Methodology: Key elements of SEE are identified from various business excellence and sustainability reporting sources, including the Global Reporting Initiative...... assessment approach similar in structure to those behind established excellence awards are developed that enable enterprise assessment of progress toward SEE. The resulting assessment is delivered in a highly consumable, combined narrative and graphic format referred to as a SEE NEWS Report. Practical...

  20. A Framework for a Decision Support System in a Hierarchical Extended Enterprise Decision Context

    Science.gov (United States)

    Boza, Andrés; Ortiz, Angel; Vicens, Eduardo; Poler, Raul

    Decision Support System (DSS) tools provide useful information to decision makers. In an Extended Enterprise, a new goal, changes in the current objectives or small changes in the extended enterprise configuration produce a necessary adjustment in its decision system. A DSS in this context must be flexible and agile to make suitable an easy and quickly adaptation to this new context. This paper proposes to extend the Hierarchical Production Planning (HPP) structure to an Extended Enterprise decision making context. In this way, a framework for DSS in Extended Enterprise context is defined using components of HPP. Interoperability details have been reviewed to identify the impact in this framework. The proposed framework allows overcoming some interoperability barriers, identifying and organizing components for a DSS in Extended Enterprise context, and working in the definition of an architecture to be used in the design process of a flexible DSS in Extended Enterprise context which can reuse components for futures Extended Enterprise configurations.

  1. Guidelines for Inter-Enterprise Management (IEM), GLOBEMEN Deliverable D23

    DEFF Research Database (Denmark)

    Tølle, Martin; Vesterager, Johan

    2002-01-01

    This document is a deliverable of Work package 2 of the IMS Globemen (GMN) project: D23 Guidelines for Inter-Enterprise Management (IEM). IMS Globemen is an inter-regional project aiming to develop methods, tools and architectures to support inter-enterprise operations in one-of-kind industries......-Project, the developed solution for Inter-Enterprise Management. The structure of the deliverable is as follows: - Chapter 1 introduces the guidelines and outlines the structure of the deliverable - Chapter 2 defines key terms along with a list of acronyms used in the deliverable - Chapter 3 gives a general introduction...... for inter-enterprise management (IEM). - Chapter 5 contains the actual Guidelines The chapter contains guidelines for how to prepare enterprise network in being able to set up and manage virtual enterprises. The section consists of a set of activities an enterprise should/could consider when preparing...

  2. Establishing ‘Architectural Thinking’ in Organizations

    OpenAIRE

    Winter , Robert

    2016-01-01

    Part 1: Keynote; International audience; After having harvested ‘low hanging fruits’ in early stages of Enterprise Architecture Management (EAM), it becomes increasingly difficult to keep up with large benefit realizations in later stages. The focus on the traditional EAM players (IT unit, architects, enterprise management) should be widened to ‘that other 90 % of the enterprise’ that are not directly related to the IT function. In order to create impact beyond IT, it appears necessary to com...

  3. An integration strategy for large enterprises

    Directory of Open Access Journals (Sweden)

    Risimić Dejan

    2007-01-01

    Full Text Available Integration is the process of enabling a communication between disparate software components. Integration has been the burning issue for large enterprises in the last twenty years, due to the fact that 70% of the development and deployment budget is spent on integrating complex and heterogeneous back-end and front-end IT systems. The need to integrate existing applications is to support newer, faster, more accurate business processes and to provide meaningful, consistent management information. Historically, integration started with the introduction of point-to-point approaches evolving into simpler hub-and spoke topologies. These topologies were combined with custom remote procedure calls, distributed object technologies and message-oriented middleware (MOM, continued with enterprise application integration (EAI and used an application server as a primary vehicle for integration. The current phase of the evolution is service-oriented architecture (SOA combined with an enterprise service bus (ESB. Technical aspects of the comparison between the aforementioned technologies are analyzed and presented. The result of the study is the recommended integration strategy for large enterprises.

  4. A Reference Architecture for Network-Centric Information Systems

    National Research Council Canada - National Science Library

    Renner, Scott; Schaefer, Ronald

    2003-01-01

    This paper presents the "C2 Enterprise Reference Architecture" (C2ERA), which is a new technical concept of operations for building information systems better suited to the Network-Centric Warfare (NCW) environment...

  5. Vorinostat, Rituximab, Ifosfamide, Carboplatin, and Etoposide in Treating Patients With Relapsed or Refractory Lymphoma or Previously Untreated T-Cell Non-Hodgkin Lymphoma or Mantle Cell Lymphoma

    Science.gov (United States)

    2017-04-17

    Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Mycosis Fungoides/Sezary Syndrome; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage II Mycosis Fungoides/Sezary Syndrome; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Waldenström Macroglobulinemia

  6. Lymphoma classification update: B-cell non-Hodgkin lymphomas.

    Science.gov (United States)

    Jiang, Manli; Bennani, N Nora; Feldman, Andrew L

    2017-05-01

    Lymphomas are classified based on the normal counterpart, or cell of origin, from which they arise. Because lymphocytes have physiologic immune functions that vary both by lineage and by stage of differentiation, the classification of lymphomas arising from these normal lymphoid populations is complex. Recent genomic data have contributed additional complexity. Areas covered: Lymphoma classification follows the World Health Organization (WHO) system, which reflects international consensus and is based on pathological, genetic, and clinical factors. A 2016 revision to the WHO classification of lymphoid neoplasms recently was reported. The present review focuses on B-cell non-Hodgkin lymphomas, the most common group of lymphomas, and summarizes recent changes most relevant to hematologists and other clinicians who care for lymphoma patients. Expert commentary: Lymphoma classification is a continually evolving field that needs to be responsive to new clinical, pathological, and molecular understanding of lymphoid neoplasia. Among the entities covered in this review, the 2016 revision of the WHO classification particularly impact the subclassification and genetic stratification of diffuse large B-cell lymphoma and high-grade B-cell lymphomas, and reflect evolving criteria and nomenclature for indolent B-cell lymphomas and lymphoproliferative disorders.

  7. Primary splenic lymphoma

    International Nuclear Information System (INIS)

    Aslam, M.; Salamat, N.; Mamoon, N.; Ahmed, M.

    2006-01-01

    A middle-aged lady presented with fever and splenomegaly and had been provisionally treated for malaria, typhoid and tuberculosis. Diagnostic splenectomy was performed which revealed diffuse large cell lymphoma, B type, localized to spleen. Patient had remission of disease after splenectomy. (author)

  8. Primary splenic lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Aslam, M [Combined Military Hospital, Multan (Pakistan). Dept. of Surgery; Salamat, N [Combined Military Hospital, Multan (Pakistan). Dept. of Pathology; Mamoon, N [Armed Forces Inst. of Pathology, Rawalpindi (Pakistan). Dept. of Histopathology; Ahmed, M [Combined Military Hospital, Multan (Pakistan). Dept. of Medicine

    2006-04-15

    A middle-aged lady presented with fever and splenomegaly and had been provisionally treated for malaria, typhoid and tuberculosis. Diagnostic splenectomy was performed which revealed diffuse large cell lymphoma, B type, localized to spleen. Patient had remission of disease after splenectomy. (author)

  9. Lymphoma: Immune Evasion Strategies

    International Nuclear Information System (INIS)

    Upadhyay, Ranjan; Hammerich, Linda; Peng, Paul; Brown, Brian; Merad, Miriam; Brody, Joshua D.

    2015-01-01

    While the cellular origin of lymphoma is often characterized by chromosomal translocations and other genetic aberrations, its growth and development into a malignant neoplasm is highly dependent upon its ability to escape natural host defenses. Neoplastic cells interact with a variety of non-malignant cells in the tumor milieu to create an immunosuppressive microenvironment. The resulting functional impairment and dysregulation of tumor-associated immune cells not only allows for passive growth of the malignancy but may even provide active growth signals upon which the tumor subsequently becomes dependent. In the past decade, the success of immune checkpoint blockade and adoptive cell transfer for relapsed or refractory lymphomas has validated immunotherapy as a possible treatment cornerstone. Here, we review the mechanisms by which lymphomas have been found to evade and even reprogram the immune system, including alterations in surface molecules, recruitment of immunosuppressive subpopulations, and secretion of anti-inflammatory factors. A fundamental understanding of the immune evasion strategies utilized by lymphomas may lead to better prognostic markers and guide the development of targeted interventions that are both safer and more effective than current standards of care

  10. Lymphoma: Immune Evasion Strategies

    Energy Technology Data Exchange (ETDEWEB)

    Upadhyay, Ranjan; Hammerich, Linda; Peng, Paul [Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029 (United States); Brown, Brian [Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029 (United States); Merad, Miriam [Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029 (United States); Brody, Joshua D., E-mail: joshua.brody@mssm.edu [Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029 (United States)

    2015-04-30

    While the cellular origin of lymphoma is often characterized by chromosomal translocations and other genetic aberrations, its growth and development into a malignant neoplasm is highly dependent upon its ability to escape natural host defenses. Neoplastic cells interact with a variety of non-malignant cells in the tumor milieu to create an immunosuppressive microenvironment. The resulting functional impairment and dysregulation of tumor-associated immune cells not only allows for passive growth of the malignancy but may even provide active growth signals upon which the tumor subsequently becomes dependent. In the past decade, the success of immune checkpoint blockade and adoptive cell transfer for relapsed or refractory lymphomas has validated immunotherapy as a possible treatment cornerstone. Here, we review the mechanisms by which lymphomas have been found to evade and even reprogram the immune system, including alterations in surface molecules, recruitment of immunosuppressive subpopulations, and secretion of anti-inflammatory factors. A fundamental understanding of the immune evasion strategies utilized by lymphomas may lead to better prognostic markers and guide the development of targeted interventions that are both safer and more effective than current standards of care.

  11. Leukemia & Lymphoma Society

    Science.gov (United States)

    ... be the exclusive property of The Leukemia & Lymphoma Society which in its sole discretion may use this material as it sees fit. I agree to the terms of the Standard Photography Release.* Submit * This field is required * Please fix the validation error messages in the Form Your story was ...

  12. Distributed Services with OpenAFS For Enterprise and Education

    CERN Document Server

    Milicchio, Franco

    2007-01-01

    Shows in detail how to build enterprise-level secure, redundant, and highly scalable services from scratch on top of the open source Linux operating system, suitable for small companies as well as big universities. This book presents the core architecture, based on Kerberos, LDAP, AFS, and Samba.

  13. Business service modeling for the service-oriented enterprise

    NARCIS (Netherlands)

    Jayasinghe Arachchig, J.; Weigand, H.; Jeusfeld, M.A.

    2012-01-01

    Service-oriented architectures are the upcoming business standard for realizing enterprise information systems, thus creating a need for analysis and design methods that are truly service-oriented. Most research on this topic so far takes a strict software engineering perspective. For a proper

  14. Service-oriented enterprise modelling and analysis: a case study

    NARCIS (Netherlands)

    Iacob, Maria Eugenia; Jonkers, H.; Lankhorst, M.M.; Steen, M.W.A.

    2007-01-01

    In order to validate the concepts and techniques for service-oriented enterprise architecture modelling, developed in the ArchiMate project (Lankhorst, et al., 2005), we have conducted a number of case studies. This paper describes one of these case studies, conducted at the Dutch Tax and Customs

  15. Enterprise interoperability with SOA: a survey of service composition approaches

    NARCIS (Netherlands)

    Mantovaneli Pessoa, Rodrigo; Goncalves da Silva, Eduardo; van Sinderen, Marten J.; Quartel, Dick; Ferreira Pires, Luis

    Service-oriented architecture (SOA) claims to facilitate the construction of flexible and loosely coupled business applications, and therefore is seen as an enabling factor for enterprise interoperability. The concept of service, which is central to SOA, is very convenient to address the matching of

  16. A comparative analysis of pricing models for enterprise cloud platforms

    CSIR Research Space (South Africa)

    Mvelase, P

    2013-09-01

    Full Text Available on the realization that it is not economically viable for SMMEs to acquire their own private cloud infrastructure or even subscribe to public cloud services as a single entity. In our VE-enabled cloud enterprise architecture for SMMEs, temporary co...

  17. Service commitments and capabilities across ArchiMate architectural layers

    NARCIS (Netherlands)

    Nardi, Julio Cesar; A. Almeida, João Paulo; Pereira, Maiara Candido; de Almeida Falbo, Ricardo; Iacob, Maria Eugenia; van Sinderen, Marten J.; Ferreira Pires, Luis

    ArchiMate is a widely adopted enterprise architecture modeling language that includes the “service‿ construct as a key structuring element across its enterprise layers. A previous analysis of the use of this construct within ArchiMate’s business layer concluded that it fails to represent some

  18. Flexible Scenarios to build a Service Oriented Architecture on Demand

    African Journals Online (AJOL)

    pc

    2018-03-22

    Mar 22, 2018 ... technology and business requirements that could be used in a real Enterprise ... Keywords - Service Oriented Architecture, Service Enterprise,. Lego Model, On ... In the recent years, many companies have chosen ... management and more formal approaches through in-depth interviews .... Eng.,12: 74-78.

  19. Marshall Application Realignment System (MARS) Architecture

    Science.gov (United States)

    Belshe, Andrea; Sutton, Mandy

    2010-01-01

    The Marshall Application Realignment System (MARS) Architecture project was established to meet the certification requirements of the Department of Defense Architecture Framework (DoDAF) V2.0 Federal Enterprise Architecture Certification (FEAC) Institute program and to provide added value to the Marshall Space Flight Center (MSFC) Application Portfolio Management process. The MARS Architecture aims to: (1) address the NASA MSFC Chief Information Officer (CIO) strategic initiative to improve Application Portfolio Management (APM) by optimizing investments and improving portfolio performance, and (2) develop a decision-aiding capability by which applications registered within the MSFC application portfolio can be analyzed and considered for retirement or decommission. The MARS Architecture describes a to-be target capability that supports application portfolio analysis against scoring measures (based on value) and overall portfolio performance objectives (based on enterprise needs and policies). This scoring and decision-aiding capability supports the process by which MSFC application investments are realigned or retired from the application portfolio. The MARS Architecture is a multi-phase effort to: (1) conduct strategic architecture planning and knowledge development based on the DoDAF V2.0 six-step methodology, (2) describe one architecture through multiple viewpoints, (3) conduct portfolio analyses based on a defined operational concept, and (4) enable a new capability to support the MSFC enterprise IT management mission, vision, and goals. This report documents Phase 1 (Strategy and Design), which includes discovery, planning, and development of initial architecture viewpoints. Phase 2 will move forward the process of building the architecture, widening the scope to include application realignment (in addition to application retirement), and validating the underlying architecture logic before moving into Phase 3. The MARS Architecture key stakeholders are most

  20. REST in practice Hypermedia and systems architecture

    CERN Document Server

    Webber, Jim; Robinson, Ian

    2010-01-01

    Why don't typical enterprise projects go as smoothly as projects you develop for the Web? Does the REST architectural style really present a viable alternative for building distributed systems and enterprise-class applications? In this insightful book, three SOA experts provide a down-to-earth explanation of REST and demonstrate how you can develop simple and elegant distributed hypermedia systems by applying the Web's guiding principles to common enterprise computing problems. You'll learn techniques for implementing specific Web technologies and patterns to solve the needs of a typical com

  1. Data architecture from zen to reality

    CERN Document Server

    Tupper, Charles D

    2011-01-01

    Data Architecture: From Zen to Reality explains the principles underlying data architecture, how data evolves with organizations, and the challenges organizations face in structuring and managing their data. It also discusses proven methods and technologies to solve the complex issues dealing with data. The book uses a holistic approach to the field of data architecture by covering the various applied areas of data, including data modelling and data model management, data quality , data governance, enterprise information management, database design, data warehousing, and warehouse design. This book is a core resource for anyone emplacing, customizing or aligning data management systems, taking the Zen-like idea of data architecture to an attainable reality.

  2. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

    Science.gov (United States)

    ... Non-Hodgkin Lymphoma Peripheral T-Cell Lymphoma Primary Central Nervous System Lymphoma T-Cell Lymphoma Transformed Mycosis Fungoides Waldenstrom Macroglobulinemia Young Adult Lymphoma Overview Treatment Options Relapsed/Refractory Long-Term ...

  3. SharePoint 2010 Enterprise Architect's Guidebook

    CERN Document Server

    Wilson, Brian; Baer, Bill; Kearn, Martin; Shah, Arpan; Adams, Jim; Bridport, Nigel; Esperanca, Huge; Gideon, Chris; Hassani, Sam; Hodgkinson, Neil; Juvonen, Vesa; Kleven, Scott; Morrish, Ian; Olenick, Paul; Ranlett, Matt; Voskresenskaya, Natalya; Walker, Simon; Whitehead, Chris

    2012-01-01

    Tips and techniques for becoming a successful SharePoint architect If you're eager to design and architect a successful deployment of SharePoint 2010, then this is the book for you. Packed with real-world experiences and solid processes, this guidebook provides you with everything you need to perform for designing and architecting enterprise portal services. Helpful examples examine the common design issues affecting SharePoint 2010 environments that can cause deployments to fail so you can learn what to avoid. Plus, key development and deployment issues are covered from an architecture perspe

  4. The Cluster Enterprise of Real Property Business

    DEFF Research Database (Denmark)

    Stubkjær, Erik

    2008-01-01

    others. The paper regards the domain of real property transactions. Drawing on research of European scope, it analyzes the framework of business processes in order to facilitate adoption of service oriented architectures. The paper motivates the notion of a ‘cluster enterprise' and identifies further......In order to apply the potential of available web technology, business processes must be described in a coherent way across organizational boundaries. Business processes include geographical data in the context of constructions, as well as environmental affairs and real property transactions, among...... steps towards a standardization of real estate business....

  5. Multimodality imaging of cardiothoracic lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Carter, Brett W., E-mail: bcarter2@mdanderson.org [The University of Texas MD Anderson Cancer Center, Department of Diagnostic Radiology, Section of Thoracic Imaging, 1515 Holcombe Blvd., Unit 1478, Houston, TX 77030 (United States); Wu, Carol C. [Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, FND-202, Boston, MA 02114 (United States); Khorashadi, Leila [Department of Radiology, Mount Auburn Hospital, Cambridge, MA 02138 (United States); Godoy, Myrna C.B.; Groot, Patricia M. de [The University of Texas MD Anderson Cancer Center, Department of Diagnostic Radiology, Section of Thoracic Imaging, 1515 Holcombe Blvd., Unit 1478, Houston, TX 77030 (United States); Abbott, Gerald F. [Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, FND-202, Boston, MA 02114 (United States); Lichtenberger III, John P. [Department of Radiology, David Grant Medical Center, Travis AFB, CA 94535 (United States)

    2014-08-15

    Lymphoma is the most common hematologic malignancy and represents approximately 5.3% of all cancers. The World Health Organization published a revised classification scheme in 2008 that groups lymphomas by cell type and molecular, cytogenetic, and phenotypic characteristics. Most lymphomas affect the thorax at some stage during the course of the disease. Affected structures within the chest may include the lungs, mediastinum, pleura, and chest wall, and lymphomas may originate from these sites as primary malignancies or secondarily involve these structures after arising from other intrathoracic or extrathoracic sources. Pulmonary lymphomas are classified into one of four types: primary pulmonary lymphoma, secondary pulmonary lymphoma, acquired immunodeficiency syndrome-related lymphoma, and post-transplantation lymphoproliferative disorders. Although pulmonary lymphomas may produce a myriad of diverse findings within the lungs, specific individual features or combinations of features can be used, in combination with secondary manifestations of the disease such as involvement of the mediastinum, pleura, and chest wall, to narrow the differential diagnosis. While findings of thoracic lymphoma may be evident on chest radiography, computed tomography has traditionally been the imaging modality used to evaluate the disease and effectively demonstrates the extent of intrathoracic involvement and the presence and extent of extrathoracic spread. However, additional modalities such as magnetic resonance imaging of the thorax and {sup 18}F-FDG PET/CT have emerged in recent years and are complementary to CT in the evaluation of patients with lymphoma. Thoracic MRI is useful in assessing vascular, cardiac, and chest wall involvement, and PET/CT is more accurate in the overall staging of lymphoma than CT and can be used to evaluate treatment response.

  6. Acceptance of enterprise resource planning systems by small manufacturing enterprises

    CSIR Research Space (South Africa)

    Adam, R

    2011-06-01

    Full Text Available systems by small enterprises. This paper addresses this gap by considering the strategic, business, technical and human factors that influence the acceptance of ERP systems in small manufacturing enterprises in South Africa. The consultative list...

  7. Empowerment Zones and Enterprise Districts - MDC_EnterpriseZone

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Polygon feature class of Miami Dade County Enterprise Zones. Enterprise Zones are special areas in the county where certain incentives from the State are available...

  8. Minority Business Enterprises and Woman Business Enterprises Grant Utilization

    Science.gov (United States)

    The policy goal of the MBE/WBE Programs is to assure that minority business enterprises and woman business enterprises are given the opportunity to participate in contract and procurement for supplies, construction, equipment & services under any EPA grant

  9. Enterprise Social Media

    DEFF Research Database (Denmark)

    Khajeheian, Datis

    2018-01-01

    This article reports an ethnographic research on effect of enterprise social media on communication of members in entrepreneurial teams. The researcher acted as an entrepreneur and as a team member in two entrepreneurial projects to observe the communication of team members within the enterprise...... social media. In addition to observation, he conducted some interviews with team members to collect supplementary data. A theoretical framework developed from an array of three metaphors: leaky pipe, echo chamber and social lubricant, and four organizational learning processes: social capital, boundary...... work, attention allocation and social analytics. By the interpretation of the collected data, a new metaphor of “living room” was proposed. This metaphor suggests that enterprise social media provide a space for interaction of internal-external people similar to what home members and guests do...

  10. SOURCES OF ENTERPRISE VALUE

    Directory of Open Access Journals (Sweden)

    Viorica Mădălina Ion

    2016-05-01

    Full Text Available The value of the enterprise has an increased importance in business valuation, so maximizing it becomes a priority for the interested parties, such as its shareholders or investors. The purpose of this article is the analysis of the sources of enterprise value and its factors, in order to understand the causes of the decrease or the possibilities for maximizing the enterprise value, passing over the main concepts in the literature. The analysis refers to the listed companies on the Bucharest Stock Exchange (BVB from the energy sector, including the largest Romanian company as per its capitalization, OMV Petrom. The research took into account the fact that the analysis of a large company with a long history is facilitated by the existence of multi-annual information, unlike the firms in the early life cycle operating in an emerging market.

  11. Abdominal Burkitt lymphoma

    International Nuclear Information System (INIS)

    Alvarez, Romina J.; Villavicencio, Roberto L.; Oxilia, Hector G.

    2004-01-01

    Purpose: As scarce information is available, in this research we have tried to describe the imaging findings of the Burkitt's lymphoma. Retrospective analysis of the clinical and imaging presentation of a 4 years old boy, is given. Biopsy confirmed the BL. Different imaging techniques were combined. The X-rays were negative. The US revealed a moderate hepatomegaly with multiple hypoechoic nodules and free fluid in the abdominal cavity. The CT showed the hepatomegaly as well as solid nodules in great number and different sizes(due to the densitometric behaviour and to post contrast enhancement), a scarce amount of ascites and a density increase of the mesentery fat. The MRI characterized and revealed in detail the US and the CT findings. The Burkitt's lymphoma is a rare entity; several methods are needed to approach the diagnosis. It represents a great clinical and imaging challenge. (author)

  12. Malignant lymphomas of the stomach

    International Nuclear Information System (INIS)

    Drgona, L.

    2011-01-01

    Primary gastric lymphomas are the most common extra nodal lymphomas. They can be presented as aggressive or indolent, majority of indolent lymphomas are associated to H. pylori infection. The basic diagnostic procedures are endoscopy, endo sonography and biopsy of gastric tissue. Therapy is related to the histological subtype, stage, H. pylori positivity, clinical symptoms and condition of patient. The aim of the treatment is remission as well as good quality of life. The prognosis of patients with primary gastric lymphomas is relatively good. (author)

  13. Business architecture management architecting the business for consistency and alignment

    CERN Document Server

    Simon, Daniel

    2015-01-01

    This book presents a comprehensive overview of enterprise architecture management with a specific focus on the business aspects. While recent approaches to enterprise architecture management have dealt mainly with aspects of information technology, this book covers all areas of business architecture from business motivation and models to business execution. The book provides examples of how architectural thinking can be applied in these areas, thus combining different perspectives into a consistent whole. In-depth experiences from end-user organizations help readers to understand the abstract concepts of business architecture management and to form blueprints for their own professional approach. Business architecture professionals, researchers, and others working in the field of strategic business management will benefit from this comprehensive volume and its hands-on examples of successful business architecture management practices.​.

  14. Robotic architectures

    CSIR Research Space (South Africa)

    Mtshali, M

    2010-01-01

    Full Text Available In the development of mobile robotic systems, a robotic architecture plays a crucial role in interconnecting all the sub-systems and controlling the system. The design of robotic architectures for mobile autonomous robots is a challenging...

  15. Towards an enterprise interoperability framework

    CSIR Research Space (South Africa)

    Kotzé, P

    2010-06-01

    Full Text Available This paper presents relevant interoperability approaches and solutions applied to global/international networked (collaborative) enterprises or organisations and conceptualise an enhanced enterprise interoperability framework. The paper covers...

  16. 2008 Enterprise Transition Plan (ETP)

    National Research Council Canada - National Science Library

    England, Gordon

    2008-01-01

    The Enterprise Transition Plan (ETP) is the Department of Defense's integrated business transformation plan, which incorporates the transition plans of the Military Services, Components and the DoD Enterprise...

  17. A technological infrastructure to sustain Internetworked Enterprises

    Science.gov (United States)

    La Mattina, Ernesto; Savarino, Vincenzo; Vicari, Claudia; Storelli, Davide; Bianchini, Devis

    In the Web 3.0 scenario, where information and services are connected by means of their semantics, organizations can improve their competitive advantage by publishing their business and service descriptions. In this scenario, Semantic Peer to Peer (P2P) can play a key role in defining dynamic and highly reconfigurable infrastructures. Organizations can share knowledge and services, using this infrastructure to move towards value networks, an emerging organizational model characterized by fluid boundaries and complex relationships. This chapter collects and defines the technological requirements and architecture of a modular and multi-Layer Peer to Peer infrastructure for SOA-based applications. This technological infrastructure, based on the combination of Semantic Web and P2P technologies, is intended to sustain Internetworked Enterprise configurations, defining a distributed registry and enabling more expressive queries and efficient routing mechanisms. The following sections focus on the overall architecture, while describing the layers that form it.

  18. Architecture & Environment

    Science.gov (United States)

    Erickson, Mary; Delahunt, Michael

    2010-01-01

    Most art teachers would agree that architecture is an important form of visual art, but they do not always include it in their curriculums. In this article, the authors share core ideas from "Architecture and Environment," a teaching resource that they developed out of a long-term interest in teaching architecture and their fascination with the…

  19. Reliability Engineering for Service Oriented Architectures

    Science.gov (United States)

    2013-02-01

    Common Object Request Broker Architecture Ecosystem In software , an ecosystem is a set of applications and/or services that grad- ually build up over time...Enterprise Service Bus Foreign In an SOA context: Any SOA, service or software which the owners of the calling software do not have control of, either...SOA Service Oriented Architecture SRE Software Reliability Engineering System Mode Many systems exhibit different modes of operation. E.g. the cockpit

  20. An architecture for integration of multidisciplinary models

    DEFF Research Database (Denmark)

    Belete, Getachew F.; Voinov, Alexey; Holst, Niels

    2014-01-01

    Integrating multidisciplinary models requires linking models: that may operate at different temporal and spatial scales; developed using different methodologies, tools and techniques; different levels of complexity; calibrated for different ranges of inputs and outputs, etc. On the other hand......, Enterprise Application Integration, and Integration Design Patterns. We developed an architecture of a multidisciplinary model integration framework that brings these three aspects of integration together. Service-oriented-based platform independent architecture that enables to establish loosely coupled...

  1. Ixazomib Citrate and Rituximab in Treating Patients With Indolent B-cell Non-Hodgkin Lymphoma

    Science.gov (United States)

    2018-02-05

    Chronic Lymphocytic Leukemia; Follicular Lymphoma; Lymphoplasmacytic Lymphoma; Mantle Cell Lymphoma; Marginal Zone Lymphoma; Recurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Refractory Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Small Lymphocytic Lymphoma; Waldenstrom Macroglobulinemia

  2. Primary cutaneous lymphoma

    International Nuclear Information System (INIS)

    Nguyen, M. Connie; Cleary, Sean F.; Hoppe, Richard T.

    1995-01-01

    Purpose: A retrospective review analyzed the survival and freedom from relapse of patients with stage IE or IIE primary cutaneous lymphoma (non mycosis fungoides) after treatments with radiation therapy alone (XRT), chemotherapy alone (RX) or combined modality therapy (CMT). Methods and Materials: Fifty two patients with stage IE-IIE cutaneous lymphoma treated at Stanford University Hospital were reviewed. The median age was 57, with a range of 26 to 94 and a male to female ratio of 1.21:1. Patients were staged according to the Ann Arbor System. Pathology was classified according to the Working Formulation. Treatment outcomes were compared using Kaplan-Meier survival curves with a Gehan p-value test. Results: The follow up range was 6 months to 22 years (median 7 years.) Twenty one percent of patients had low grade, 63% had intermediate grade and 15% had high grade lymphoma. The most common histologic subtype was diffuse large cell lymphoma Thirty two patients received radiation alone as initial treatment and sixteen patients received combined modality as initial treatment. Four patients received chemotherapy alone. The only significant prognostic factor for survival was the stage at diagnosis. Patients with stage IE disease had a longer actuarial survival (5-yr=79%, 10-yr=71%), as compared to those with stage IIE (5-yr=49%, 10-yr=33%), (p=0.029). The only significant prognostic factor for freedom from relapse was the initial treatment. Initial combined modality treatment lead to a longer freedom from relapse compared to patients treated with radiation alone (p=0.002), (median 5 years vs. 1.2 years). Despite this, the actuarial overall survival in the combined modality group and the radiation alone group are similar (median survival 7.7 and 8 years). The efficacy of either radiation or chemotherapy as salvage treatment after radiation failure was equivalent and both salvage treatments lead to equally long survival and freedom from second relapse. Conclusion

  3. Primary cutaneous lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, M Connie; Cleary, Sean F; Hoppe, Richard T

    1995-07-01

    Purpose: A retrospective review analyzed the survival and freedom from relapse of patients with stage IE or IIE primary cutaneous lymphoma (non mycosis fungoides) after treatments with radiation therapy alone (XRT), chemotherapy alone (RX) or combined modality therapy (CMT). Methods and Materials: Fifty two patients with stage IE-IIE cutaneous lymphoma treated at Stanford University Hospital were reviewed. The median age was 57, with a range of 26 to 94 and a male to female ratio of 1.21:1. Patients were staged according to the Ann Arbor System. Pathology was classified according to the Working Formulation. Treatment outcomes were compared using Kaplan-Meier survival curves with a Gehan p-value test. Results: The follow up range was 6 months to 22 years (median 7 years.) Twenty one percent of patients had low grade, 63% had intermediate grade and 15% had high grade lymphoma. The most common histologic subtype was diffuse large cell lymphoma Thirty two patients received radiation alone as initial treatment and sixteen patients received combined modality as initial treatment. Four patients received chemotherapy alone. The only significant prognostic factor for survival was the stage at diagnosis. Patients with stage IE disease had a longer actuarial survival (5-yr=79%, 10-yr=71%), as compared to those with stage IIE (5-yr=49%, 10-yr=33%), (p=0.029). The only significant prognostic factor for freedom from relapse was the initial treatment. Initial combined modality treatment lead to a longer freedom from relapse compared to patients treated with radiation alone (p=0.002), (median 5 years vs. 1.2 years). Despite this, the actuarial overall survival in the combined modality group and the radiation alone group are similar (median survival 7.7 and 8 years). The efficacy of either radiation or chemotherapy as salvage treatment after radiation failure was equivalent and both salvage treatments lead to equally long survival and freedom from second relapse. Conclusion

  4. President's categorical course on lymphoma

    International Nuclear Information System (INIS)

    Hoppe, Richard T.

    1997-01-01

    Improvements in the classification, staging, and treatment of the lymphomas, complemented by an improved understanding of the biology of these diseases, has led to an improved outcome of therapy for both Hodgkin's disease and many of the non-Hodgkin's lymphomas. The rapid changes that have occurred in this field in the last decade make it timely to review this subject for radiation oncologists in a comprehensive fashion. This course is designed to meet broad educational needs required for understanding these diseases and providing effective care for patients with lymphoma. The faculty includes many leaders from both laboratory and clinical disciplines dealing with lymphomas, who will address a variety of scientific and clinical topics. The morning session will be devoted to Hodgkin's disease, including new concepts in its biology, a review of clinical trials for early stage disease, a discussion of the role of high dose therapy, and description of long term complications of treatment. The afternoon sessions will be devoted to the non-Hodgkin's lymphomas, including new concepts in pathology and biology, a description of specific entities including the low grade lymphomas, MALT lymphomas, extranodal lymphomas, intermediate grade lymphomas, mantle cell lymphomas, and summary discussions of the role of radioimmuno-therapy and high dose therapy. Although the role of radiation therapy in the management of patients with lymphoma has changed dramatically in the past two decades, radiation remains the most effective single agent for the treatment of these diseases and it is especially important for radiation onologists to keep abreast of these new concepts. This course has been designed to achieve that goal

  5. Management strategy of enterprise

    Directory of Open Access Journals (Sweden)

    Osovskiy O.A.

    2017-03-01

    Full Text Available The development of market relations, increasing competition result in the accelerated necessity in strategic management as one of the most efficient and progressive means of organization management. The article deals with such researching methods as SWOT analysis (studying strength and weak points, manufacturing feasibilities of an enterprise and threats caused by environment, BCG matrix (while determining marketing roles of output, Mack Kinsey (determining branch attraction, the tree of aims (looking for perspective directions of development, and also other well-known tools of strategic management. SE «Zhytomyr distillery» is the enterprise with over century traditions of production quality of its output. The results of the SWOT analysis has allowed to determine the lines of behavior due to favorable and unfavorable factors of environment. At present, the enterprise has much strength and manufacturing feasibilities, therefore, the principal directions of its activity have to become the improvement of its technological base, the expansion of output range and sale at the expense of free financial resources. The calculations made by the authors allowed them to develop the main strategies for development of an enterprise. The practical value of the calculations lies in keeping competitive lines both on the domestic market of Ukraine and on the foreign international market.

  6. Education and Enterprise.

    Science.gov (United States)

    Emery, John S.

    1987-01-01

    In Australia, one effect of reduced government funding is to stimulate enterprise in higher education. This paper supports extending cooperation and joint ventures with industry and commerce and initiating new practices, such as exporting educational services or establishing a private education sector. A major drawback is the equity issue.…

  7. Danish social enterprises

    DEFF Research Database (Denmark)

    Hulgård, Lars

    2006-01-01

    Nye organisationer som er drevet af innovation og entreprenørskab men fokuseret på sociale målsætninger og værdier er på vej frem i Europa. Bogen er en komparativ og tværvidenskabelig analyse af sådanne sociale virksomheder (social enterprises)....

  8. Enterprise Oil gets going

    International Nuclear Information System (INIS)

    Ross, Priscilla.

    1996-01-01

    Enterprise Oil is a mature United Kingdom independent oil exploration and production company. In its early years, with the success of the Nelson platform in the North Sea, the company had been well rated by financial analysts in the City of London. Enterprise was floated as an independent company on the International Stock Exchange in London in 1984 having previously been part of the establishment being formed by the Government from the oil and production interests of British Gas on the UK Continental shelf. Relationships with the City suffered, however, as a result of the unsuccessful outcome of moves by the company to take over Lasmo, the only other UK independent oil company of comparable magnitude. Pedestrian financial results and poor exploration results led to Enterprise dividends being stuck in a rut from 1992 onwards. This report, however, shows how that situation is changing so that the company's share price has been reaching new highs. Enterprise has been adding quantitative value to the company through swaps, farm-in deals and licensed acquisitions and now has interests in core income producing areas in the UK, Norway, Denmark and Italy. (UK)

  9. Transformation of marginal zone lymphoma (and association with other lymphomas).

    Science.gov (United States)

    Casulo, Carla; Friedberg, Jonathan

    Marginal zone lymphomas (MZL) are a diverse group of indolent lymphoproliferative disorders that comprise three subtypes: nodal, splenic and mucosal associated marginal zone lymphomas (MALT). Histologic transformation (HT) to an aggressive lymphoma is a rare event that can occur in any subtype, and at lower frequency compared to other indolent non Hodgkin lymphomas (NHL) like follicular lymphoma. There are few data directly associated with risk and prognosis of transformation in MZL. However, recent advances in the understanding of molecular and genetic features of MALT have contributed to an evolving appreciation of HT in this disease. Optimal treatment of HT of MZL remains unknown. Much of the approach to managing transformed MZL is extrapolated from other indolent NHLs. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. Composite lymphoma: Mycosis fungoides with hodgkin′s lymphoma

    Directory of Open Access Journals (Sweden)

    Mehta Jalpa

    2005-01-01

    Full Text Available Mycosis fungoides (MF is a malignant lymphoma, primarily of the skin and is characterized by infiltration of the skin by atypical T-cells which have a tendency for epidermotropism. Hodgkins disease (HD is considered to be a malignant lymphoma affecting predominantly the lymph nodes and characterized by presence of Reed- Sternberg cells on histopathology, though, the exact origin of the Reed Sternberg cell and the nature of the malignant cell is not known yet. Few cases of association of mycosis fungoides with Hodgkin′s lymphoma have been reported in the literature. It was reported in the past that when mycosis fungoides spreads to the lymph nodes and other viscera it frequently gets transformed into a more common lymphoma like Hodgkin′s lymphoma. However it has now been proved that the two malignancies are distinct and that such patients probably have a tumour diathesis.

  11. The Social Responsibility of Enterprises

    DEFF Research Database (Denmark)

    Rosdahl, Anders

    More than 20 per cent of the Danish working age population is provided for by some form of public income transfer. The goal of the present government is that enterprises should employ more of these persons: Enterprises should become more socially responsible. The paper analyses enterprises...

  12. ENTERPRISES DEVELOPMENT: MANAGEMENT MODEL

    Directory of Open Access Journals (Sweden)

    Lina Shenderivska

    2018-01-01

    Full Text Available The paper’s purpose is to provide recommendations for the effective managing the companies’ development taking into account the sectoral key elements’ transformation. Methodology. The enterprise profits’ econometric simulation is conducted to determine the most significant factors influencing their development. According to the model testing result, their multicollinearity was revealed. To get rid of the multicollinearity phenomenon from the profit models, isolated regressors are excluded, namely, return on assets, material returns, return on equity. To obtain qualitative models with a small error of model parameters estimation and, accordingly, high reliability of the conclusion about the interrelation between the factors of the model and the resulting feature, factors in the income model that are not closely interconnected, that is, not multicollinear, are included. Determination coefficients R2 and F-criterion were calculated for model quality checking. The modern printing enterprises of Ukraine key elements, connected with integration into the global information space, are analysed. Results. The interrelation between a company’s development and earning capacity is identified in the study. The profit importance as the main source for enterprise financing is substantiated. Factors that have the greatest impact on the enterprises’ development are labour productivity, financial autonomy, working capital turnover, and the character of their influence is most adequately reflected by the power model. Peculiarities of the enterprises’ activity include increased competition at the inter-branch level, poorly developed industrial relations, and the own sources of financing activities shortage. Practical implications. Based on information on the most significant developmental impact factors, directions for perspective enterprises development for their competitiveness increase are proposed: diversification based on the activity expansion

  13. Clustering of agricultural enterprises

    Directory of Open Access Journals (Sweden)

    Michaela Beranová

    2013-01-01

    Full Text Available Agricultural business is a very specific branch which is characterized by very low financial performance while this characteristic is given mainly by external factors as market pricing of agricultural commodities on one side, and production costs of agricultural commodities on the other side. This way, agricultural enterprises recognize negative values of gross margin in the Profit and Loss Statement but positive value of operating profit after even there are items of costs which are deducted. These results are derived from agricultural production subsidies which are recognized as income in the P/L Statement. In connection with this fact, the government subsidies are a substantial component of financial performance of agricultural enterprises.Primary research proceeded on the statistical sample of one hundred agricultural companies, has shown that also other specifics influencing financial performance of these businesses exist here. In order to determine the influences, the cluster analysis has been applied at using more than 10 variables. This approach has led to construction of clusters (groups of agricultural business entities with different characteristics of the group. The objective of this paper is to identify the main determinants of financial performance of agricultural enterprises and to determine their influences under different economic characteristics of these business entities. For this purpose, the regression analysis has been subsequently applied on the groups of companies coming out from the cluster analysis. Besides the operating profit which is the main driving force of financial performance measured with the economic value added (EVA in agricultural enterprises, also capital structure and cost of capital have been observed as very strong influences on financial performance but these factors have different directions of their influence on the economic value added under different financial characteristics of agricultural

  14. Semantic web technologies for enterprise 2.0

    CERN Document Server

    Passant, A

    2010-01-01

    In this book, we detail different theories, methods and implementations combining Web 2.0 paradigms and Semantic Web technologies in Enterprise environments. After introducing those terms, we present the current shortcomings of tools such as blogs and wikis as well as tagging practices in an Enterprise 2.0 context. We define the SemSLATES methodology and the global vision of a middleware architecture based on Semantic Web technologies and Linked Data principles (languages, models, tools and protocols) to solve these issues. Then, we detail the various ontologies that we build to achieve this g

  15. Active resources concept of computation for enterprise software

    Directory of Open Access Journals (Sweden)

    Koryl Maciej

    2017-06-01

    Full Text Available Traditional computational models for enterprise software are still to a great extent centralized. However, rapid growing of modern computation techniques and frameworks causes that contemporary software becomes more and more distributed. Towards development of new complete and coherent solution for distributed enterprise software construction, synthesis of three well-grounded concepts is proposed: Domain-Driven Design technique of software engineering, REST architectural style and actor model of computation. As a result new resources-based framework arises, which after first cases of use seems to be useful and worthy of further research.

  16. MDX-010 in Treating Patients With Recurrent or Refractory Lymphoma

    Science.gov (United States)

    2014-05-22

    Adult Grade III Lymphomatoid Granulomatosis; B-cell Chronic Lymphocytic Leukemia; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenström Macroglobulinemia

  17. Hodgkin's Lymphoma of the Breast

    African Journals Online (AJOL)

    TNHJOURNALPH

    RESULT. A tissue diagnosis of Hodgkin's lymphoma with typical ... It was the first cancer to be cured ... ultrasonography showed enlarged liver. The .... McMillan A, Horning S. Non-Hodgkins lymphoma of the Breast. Cancer. 2007;110:25-30. 5.

  18. Tyrosine phosphorylation in human lymphomas

    NARCIS (Netherlands)

    Haralambieva, E; Jones, M.; Roncador, GM; Cerroni, L; Lamant, L; Ott, G; Rosenwald, A; Sherman, C; Thorner, P; Kusec, R; Wood, KM; Campo, E; Falini, B; Ramsay, A; Marafioti, T; Stein, H; Kluin, PM; Pulford, K; Mason, DY

    2002-01-01

    In a previous study, we showed that the high level of protein tyrosine phosphorylation present in lymphomas containing an anaplastic lymphoma kinase (ALK) can be demonstrated in routinely processed paraffin tissue sections using immunolabelling techniques. In the present study we investigated

  19. Lymphoma risk in systemic lupus

    DEFF Research Database (Denmark)

    Bernatsky, Sasha; Ramsey-Goldman, Rosalind; Joseph, Lawrence

    2014-01-01

    OBJECTIVE: To examine disease activity versus treatment as lymphoma risk factors in systemic lupus erythematosus (SLE). METHODS: We performed case-cohort analyses within a multisite SLE cohort. Cancers were ascertained by regional registry linkages. Adjusted HRs for lymphoma were generated...

  20. Lymphoma of the Urinary Bladder

    Directory of Open Access Journals (Sweden)

    Anthony Kodzo-Grey Venyo

    2014-01-01

    Full Text Available Background. Lymphoma of the urinary bladder (LUB is rare. Aims. To review the literature on LUB. Methods. Various internet databases were used. Results. LUB can be either primary or secondary. The tumour has female predominance; most cases occur in middle-age women. Secondary LUB occurs in 10% to 25% of leukemias/lymphomas and in advanced-stage systemic lymphoma. Less than 100 cases have been reported. MALT typically affects adults older than 60 years; 75% are female. Diffuse large B-cell lymphoma is also common and may arise from transformation of MALT. LUB presents with haematuria, dysuria, urinary frequency, nocturia, and abdominal or back pain. Macroscopic examination of LUBs show large discrete tumours centred in the dome or lateral walls of the bladder. Positive staining of LUB varies by the subtype of lymphoma; B-cell lymphomas are CD20 positive. MALT lymphoma is positively stained for CD20, CD19, and FMC7 and negatively stained for CD5, CD10, and CD11c. LUB stains negatively with Pan-keratin, vimentin, CK20, and CK7. MALT lymphoma exhibits t(11; 18(q21: 21. Radiotherapy is an effective treatment for the MALT type of LUB with no recurrence. Conclusions. LUB is diagnosed by its characteristic morphology and immunohistochemical characteristics. Radiotherapy is a useful treatment.

  1. Geldanamycin Analogue in Treating Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma

    Science.gov (United States)

    2013-12-13

    Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Non-Hodgkin Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific

  2. Web Service Architecture Framework for Embedded Devices

    Science.gov (United States)

    Yanzick, Paul David

    2009-01-01

    The use of Service Oriented Architectures, namely web services, has become a widely adopted method for transfer of data between systems across the Internet as well as the Enterprise. Adopting a similar approach to embedded devices is also starting to emerge as personal devices and sensor networks are becoming more common in the industry. This…

  3. FDG-PET in lymphomas

    International Nuclear Information System (INIS)

    Knapp, W. H.

    2009-01-01

    Lymphomas are a heterogeneous group of neoplasms in which two major subtypes are distinguished, Hodgkin's disease (HD) and non-Hodgkin's lymphomas (NHL). The incidence of lymphomas is about 20 per 100000 inhabitants (Jemal et al 2002) and 7-8 times higher than that of HD. Since NHL has a worse prognosis, the death rates of NHL are 14 times higher than those for HD. Lymphomas account for about 4 % of all cancer incidences. In USA, lymphomas are the fifth most frequent cancer type diagnosed and the third most frequent form of cancer death (Jemal et al 2002). Concerning HD, there is a preponderance for males with a gender ratio of 1.33 for incidence and 1.12 for mortality. For NHL incidences and mortality rates of genders are almost equal. HL comprises different subtypes among which nodular sclerosis is the most frequent one (60-70 %). Other histopathologic subtypes are those of mixed cellularity, lymphocyte reach and lymphocyte depleted characteristics. The most frequent subgroup of NHL are B-cell lymphomas (80-90 % of all NHL). Two thirds of this subgroup are diffuse large B-cell lymphomas, one third follicular lymphomas. Other (less frequent) subtypes are mantle cell, peripheral T-cell, anaplastic large-cell-lymphomas etc. For NHL increasing incidence has been observed in the last decades. Within 15 years the incidence increased by 50 % in the USA (Jemal et al 2002). Etiology of lymphomas is still unknown. In a certain proportion of NHL viral causes are assumed. Diagnosis is based on histology (needle biopsy) with consecutive sub typing. Prognosis depends on stage, expansion state, histology and proliferation rates. (author)

  4. Psoriasis and risk of malignant lymphoma

    DEFF Research Database (Denmark)

    Kamstrup, M R; Skov, L; Zachariae, C

    2018-01-01

    In patients with psoriasis, the risk of lymphoma has been a subject of controversy and data from larger studies are limited1-4 . We therefore investigated the 5-year risk of new-onset Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL) (excluding cutaneous T-cell lymphoma [CTCL]), and CTCL...

  5. Architectural Decision Management for Digital Transformation of Products and Services

    Directory of Open Access Journals (Sweden)

    Alfred Zimmermann

    2016-04-01

    Full Text Available The digitization of our society changes the way we live, work, learn, communicate, and collaborate. The Internet of Things, Enterprise Social Networks, Adaptive Case Management, Mobility systems, Analytics for Big Data, and Cloud services environments are emerging to support smart connected products and services and the digital transformation. Biological metaphors of living and adaptable ecosystems provide the logical foundation for self-optimizing and resilient run-time environments for intelligent business services and service-oriented enterprise architectures. Our aim is to support flexibility and agile transformations for both business domains and related information technology. The present research paper investigates mechanisms for decision analytics in the context of multi-perspective explorations of enterprise services and their digital enterprise architectures by extending original architecture reference models with state of art elements for agile architectural engineering for the digitization and collaborative architectural decision support. The paper’s context focuses on digital transformations of business and IT and integrates fundamental mappings between adaptable digital enterprise architectures and service-oriented information systems. We are putting a spotlight on the example domain – Internet of Things.

  6. Primary intracranial malignant lymphoma

    International Nuclear Information System (INIS)

    Matsumoto, Mikiro; Ohtsuka, Takatsugu; Kuroki, Takao; Shibata, Iekado; Terao, Hideo; Kudo, Motoshige

    1988-01-01

    Nine cases of primary intracranial malignant lymphoma, which accounts for 3.3 % of all intracranial tumors seen in the authors' institution, were studied in terms of diagnostic computed tomographic (CT) features, the tumors' histologic appearance, treatment, post-treatment blood immunologic and cerebrospinal fluid (CSF) characteristics, and outcome. The patients were seven males and two females aged 42 to 67 years. Their chief signs and symptoms on admission were intracranial hypertension, focal signs, and disturbance of consciousness. CT, which proved the most useful preoperative diagnostic technique, demonstrated multiple lesions in seven cases and, in all cases, regions of isodensity or slight high density that were enhanced by contrast medium. According to the patterns of enhancement, the tumors were classed as diffuse (three cases) or nodular (six cases). The former is considered typical of malignant lymphoma, whereas the latter type was sometimes indistinguishable from metastatic tumor and meningioma. At surgery, one patient underwent radical tumor excision, two partial removal, and six biopsy only. Histologic examination revealed one tumor to be of the diffuse small cell type, three of the medium cell type, and five of the large cell type (Lymphoma Study Group classification). Of seven tumors in which lymphocytes were examined by peroxidase-antiperoxidase staining, four were of the B cell type. Postoperatively, whole brain irradiation with 29 to 46 Gy was followed by local irradiation with 15 to 50 Gy. If the tumor persisted, one of three chemotherapies was administered. In one case, methotrexate was given intrathecally. Seven patients were divided into two groups: long remission (three) and recurrence (four). These two groups were compared in terms of serum immunoglobulin levels, T and B cell ratios, CSF characteristics, CT features, tumor cell type, and treatment. No clear differences were found. (author)

  7. Sarcoidosis-lymphoma syndrome.

    Science.gov (United States)

    Brandy-García, Anahy M; Caminal-Montero, Luis; Fernández-García, María Soledad; Saiz Ayala, Angel; Cabezas-Rodríguez, Ivan; Morante-Bolado, Isla

    A 65 year-old female with a history of sarcoidosis with pulmonary and joint involvement, who after 5 years of diagnosis begins with central nervous system involvement manifesting as diplopia. She presents normal analysis results. In imaging results, a mass is identified in the right intraconal space; it depends of right optic nerve, and shows multiple lymph node involvement. Biopsy was performed diagnosed with large B-cell lymphoma, an atypical form of tumor associated with sarcoidosis. Copyright © 2015 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.

  8. Gastric Lymphoma with Secondary Trigeminal Nerve Lymphoma: A Case Report

    Directory of Open Access Journals (Sweden)

    Warissara Rongthong

    2017-05-01

    Full Text Available Data supporting the role of radiotherapy in secondary trigeminal nerve lymphoma is scarce. Here, I report the case of 64-year-old Thai male diagnosed as gastric diffuse large B cell lymphoma with secondary trigeminal nerve lymphoma. He had previously received one cycle of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP, followed by five cycles of rituximab plus CHOP (R-CHOP with intrathecal methotrexate (MTX and cytarabine (Ara-C. One month after the last cycle of R-CHOP, he developed a headache and numbness on the left side of his face. MRI revealed thickening of the left trigeminal nerve. He received one intrathecal injection of MTX and Ara-C, followed by systemic chemotherapy. After receiving intrathecal chemotherapy, his symptoms disappeared. Clinical response and MRI studies suggested secondary trigeminal nerve lymphoma. Two months later, our patient’s secondary trigeminal nerve lymphoma had progressed. Salvage whole brain irradiation (36 Gy with boost dose (50 Gy along the left trigeminal nerve was given. Unfortunately, our patient developed heart failure and expired during the radiotherapy session. In conclusion and specific to secondary central nervous system lymphoma (SCNSL, radiotherapy may benefit patients who fail to respond to systemic chemotherapy and palliative treatment. The results this report fail to support the role of radiotherapy in secondary trigeminal nerve lymphoma.

  9. Iodine I 131 Monoclonal Antibody BC8 Before Autologous Stem Cell Transplant in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma

    Science.gov (United States)

    2017-11-15

    Recurrent B-Cell Non-Hodgkin Lymphoma; Recurrent Hodgkin Lymphoma; Recurrent T-Cell Non-Hodgkin Lymphoma; Refractory B-Cell Non-Hodgkin Lymphoma; Refractory Hodgkin Lymphoma; Refractory T-Cell Non-Hodgkin Lymphoma

  10. Avelumab, Utomilumab, Rituximab, Ibrutinib, and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma or Mantle Cell Lymphoma

    Science.gov (United States)

    2018-06-13

    CCND1 Positive; CD20 Positive; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Mantle Cell Lymphoma; Refractory Diffuse Large B-Cell Lymphoma; Refractory Mantle Cell Lymphoma; Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma

  11. Enterprise Information Systems Outsourcing

    DEFF Research Database (Denmark)

    Svejvig, Per; Pries.Heje, Jan

    2009-01-01

    Outsourcing is now a feasible mean for Enterprise Information Systems (EIS) cost savings, but do however increase the complexity substantially when many organizations are involved. We set out to study EIS outsourcing with many interorganizational partners in a large Scandinavian high-tech organiz......Outsourcing is now a feasible mean for Enterprise Information Systems (EIS) cost savings, but do however increase the complexity substantially when many organizations are involved. We set out to study EIS outsourcing with many interorganizational partners in a large Scandinavian high...... the rational cost saving explanation; but then with a more careful analysis focusing on institutional factors, other explanations "behind the curtain" were revealed, such as management consultants with a "best practice" agenda, people promoting outsourcing thereby being promoted themselves, and outside...

  12. Enterprise Information Systems Outsourcing

    DEFF Research Database (Denmark)

    Pries-Heje, Jan; Svejvig, Per

    2009-01-01

      Outsourcing is now a feasible mean for Enterprise Information Systems (EIS) cost savings, but do however increase the complexity substantially when many organizations are involved. We set out to study EIS outsourcing with many interorganizational partners in a large Scandinavian high-tech organ......  Outsourcing is now a feasible mean for Enterprise Information Systems (EIS) cost savings, but do however increase the complexity substantially when many organizations are involved. We set out to study EIS outsourcing with many interorganizational partners in a large Scandinavian high...... the rational cost saving explanation; but then with a more careful analysis focusing on institutional factors, other explanations "behind the curtain" were revealed, such as management consultants with a "best practice" agenda, people promoting outsourcing thereby being promoted themselves, and outside...

  13. Valuation of energy enterprises

    International Nuclear Information System (INIS)

    Kjaerland, Frode

    2005-01-01

    Since the deregulation of the energy market in Norway, there has been a number of mergers and acquisitions of energy enterprises. In all these transaction the companies has been valued. The value has often been not insignificant above what the value should be according to traditional methods of valuation. What is the explanation of this premium. This paper describes a project which has as goal to test weather real option theory can explain the difference between actual price and theoretical value based on conventional discounted cash flow methods. This is supposed to be compared with an accounting based residual income approach of valuation. The goal is to see if a real option approach better can explain the value of the transactions in this industry in the past decade, and thereby better understand the value and value components of these enterprises. This is a first draft, and this paper will be rewritten and revised by the presentation in the conference ultimo August 2005. (Author)

  14. 2015 Enterprise Strategic Vision

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-08-01

    This document aligns with the Department of Energy Strategic Plan for 2014-2018 and provides a framework for integrating our missions and direction for pursuing DOE’s strategic goals. The vision is a guide to advancing world-class science and engineering, supporting our people, modernizing our infrastructure, and developing a management culture that operates a safe and secure enterprise in an efficient manner.

  15. Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma

    Science.gov (United States)

    2018-04-10

    Adult B Acute Lymphoblastic Leukemia; Adult T Acute Lymphoblastic Leukemia; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-Cell Lymphoma; Chronic Lymphocytic Leukemia; Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Hepatosplenic T-Cell Lymphoma; Intraocular Lymphoma; Lymphomatous Involvement of Non-Cutaneous Extranodal Site; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Nodal Marginal Zone Lymphoma; Primary Cutaneous B-Cell Non-Hodgkin Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-Cell Leukemia/Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides and Sezary Syndrome; Recurrent Non-Hodgkin Lymphoma; Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Small Intestinal Lymphoma; Splenic Marginal Zone Lymphoma; T-Cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenstrom Macroglobulinemia

  16. INVESTMENT ATTRACTIVENESS OF ENTERPRISES

    Directory of Open Access Journals (Sweden)

    Nadiia Davydenko

    2017-03-01

    Full Text Available In the article the approaches to defining the essence of the concept of “investment attractiveness of enterprises” were analyzed. On the example of "Agrofirm Brusilov" depth analysis of the agricultural enterprises to evaluate of profitability, liquidity, solvency, financial stability, the timing of the return of invested funds and minimizing investment risks was conducted. To study methods of rating and system analysis were used. To justify the conditions of  increasing investment attractiveness farms method of scoring was used. It was established as a result of the use of integrated evaluation of the financial position one can see problem aspects of financial position of the company and develop measures to enhance liquidity, solvency, identify potential for raising the efficiency of company and prevention of financial crisis. The analysis of financial position showed that the management of the enterprise doesn’t  think  about  financial stability and solvency, does not understand the benefit of borrowed capital. Using research results in practice of agricultural enterprises allows us to give a real evaluation of investment attractiveness and justify ways to improve it. Key words: investments, investment attractiveness, potential business, financial position.

  17. Splenic marginal zone lymphoma.

    Science.gov (United States)

    Piris, Miguel A; Onaindía, Arantza; Mollejo, Manuela

    Splenic marginal zone lymphoma (SMZL) is an indolent small B-cell lymphoma involving the spleen and bone marrow characterized by a micronodular tumoral infiltration that replaces the preexisting lymphoid follicles and shows marginal zone differentiation as a distinctive finding. SMZL cases are characterized by prominent splenomegaly and bone marrow and peripheral blood infiltration. Cells in peripheral blood show a villous cytology. Bone marrow and peripheral blood characteristic features usually allow a diagnosis of SMZL to be performed. Mutational spectrum of SMZL identifies specific findings, such as 7q loss and NOTCH2 and KLF2 mutations, both genes related with marginal zone differentiation. There is a striking clinical variability in SMZL cases, dependent of the tumoral load and performance status. Specific molecular markers such as 7q loss, p53 loss/mutation, NOTCH2 and KLF2 mutations have been found to be associated with the clinical variability. Distinction from Monoclonal B-cell lymphocytosis with marginal zone phenotype is still an open issue that requires identification of precise and specific thresholds with clinical meaning. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Haemorrhage and intestinal lymphoma

    Directory of Open Access Journals (Sweden)

    Attilia M. Pizzini

    2013-04-01

    Full Text Available Background: The prevalence of coeliac disease is around 1% in general population but this is often unrecognised. The classical presentation of adult coeliac disease is characterized by diarrhoea and malabsorption syndrome, but atypical presentations are probably more common and are characterized by iron deficiency anaemia, weight loss, fatigue, infertility, arthralgia, peripheral neuropathy and osteoporosis. Unusual are the coagulation disorders (prevalence 20% and these are due to vitamin K malabsorption (prolonged prothrombin time. Clinical case: A 64-year-old man was admitted to our Department for an extensive spontaneous haematoma of the right leg. He had a history of a small bowel resection for T-cell lymphoma, with a negative follow-up and he didn’t report any personal or familiar history of bleeding. Laboratory tests showed markedly prolonged prothrombin (PT and partial-thromboplastin time (PTT, corrected by mixing studies, and whereas platelet count and liver tests was normal. A single dose (10 mg of intravenous vitamin K normalized the PT. Several days before the patient had been exposed to a superwarfarin pesticide, but diagnostic tests for brodifacoum, bromadiolone or difenacoum were negative. Diagnosis of multiple vitamin K-dependent coagulationfactor deficiencies (II, VII, IX, X due to intestinal malabsorption was made and coeliac disease was detected. Therefore the previous lymphoma diagnosis might be closely related to coeliac disease. Conclusions: A gluten free diet improves quality of life and restores normal nutritional and biochemical status and protects against these complications.

  19. Lymphoma Caused by Intestinal Microbiota

    Directory of Open Access Journals (Sweden)

    Mitsuko L. Yamamoto

    2014-09-01

    Full Text Available The intestinal microbiota and gut immune system must constantly communicate to maintain a balance between tolerance and activation: on the one hand, our immune system should protect us from pathogenic microbes and on the other hand, most of the millions of microbes in and on our body are innocuous symbionts and some can even be beneficial. Since there is such a close interaction between the immune system and the intestinal microbiota, it is not surprising that some lymphomas such as mucosal-associated lymphoid tissue (MALT lymphoma have been shown to be caused by the presence of certain bacteria. Animal models played an important role in establishing causation and mechanism of bacteria-induced MALT lymphoma. In this review we discuss different ways that animal models have been applied to establish a link between the gut microbiota and lymphoma and how animal models have helped to elucidate mechanisms of microbiota-induced lymphoma. While there are not a plethora of studies demonstrating a connection between microbiota and lymphoma development, we believe that animal models are a system which can be exploited in the future to enhance our understanding of causation and improve prognosis and treatment of lymphoma.

  20. Demonstração dos fluxos de caixa: uma análise da captação de recursos nas empresas do setor de construção civil listadas na BM&F Bovespa = Cash flow statements: an analysis of resource acquisitions by the civil architecture enterprises listed at BM&F Bovespa

    Directory of Open Access Journals (Sweden)

    Mariane Lohn

    2012-05-01

    . Recent changes in the organizational concepts and legislation present new challenges to the accounting procedures which must guarantee trustworthiness to the decisions made in accordance with recent information. In this scenery, characterized by changes and instability, the present research had as its objective to identify the forms of acquiring financial sources used by the civil architecture enterprises which negotiate their shares at BM&F Bovespa. With this aim in mind a bibliographical research was undertaken as well as data collection. The latter covered the financial statements of 2007, 2008 and 2009, and it was noticed that more than 80% of the organizations under scrutiny acquired resources through financing activities. It was noticed that in the year of 2007 the main financing activity consisted in the capital increase of the enterprises. In the years of 2008 and 2009, however, the main forms of capitalization consisted in loan capital, financing aids and the launching of debentures. It was realized that the cash flow report is a very dynamic statement concerning information on the financing sources of enterprises besides contributing to accounting harmonization, something quite important vis-à-vis the present economic sceneries in which frequent new norms and procedures demand a dynamic flux of information as well as dynamic accounting procedures.

  1. Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant

    Science.gov (United States)

    2018-01-02

    HIV Infection; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Plasmablastic Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Non-Hodgkin Lymphoma; Recurrent Burkitt Lymphoma; Recurrent Follicular Lymphoma; Stage III Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage IV Follicular Lymphoma; Stage IV Mantle Cell Lymphoma

  2. Modeling Enterprise Authorization: A Unified Metamodel and Initial Validation

    Directory of Open Access Journals (Sweden)

    Matus Korman

    2016-07-01

    Full Text Available Authorization and its enforcement, access control, have stood at the beginning of the art and science of information security, and remain being crucial pillar of security in the information technology (IT and enterprises operations. Dozens of different models of access control have been proposed. Although Enterprise Architecture as the discipline strives to support the management of IT, support for modeling access policies in enterprises is often lacking, both in terms of supporting the variety of individual models of access control nowadays used, and in terms of providing a unified ontology capable of flexibly expressing access policies for all or the most of the models. This study summarizes a number of existing models of access control, proposes a unified metamodel mapped to ArchiMate, and illustrates its use on a selection of example scenarios and two business cases.

  3. Design of an application using microservices architecture and its deployment in the cloud

    OpenAIRE

    Fernández Garcés, Lidia

    2016-01-01

    The design of modern large business application systems is moving from monolithic enterprise architectures towards microservices based architectures. These are especially well suited to run in cloud environments, because each microservice can be developed, deployed and managed individually, which allows much more fine-grained control and scalability. Based on a concrete example, this projet should build an application using a microservice architecture, showi...

  4. Leveraging Software Architectures through the ISO/IEC 42010 standard: A Feasibility Study

    NARCIS (Netherlands)

    Tamburri, D.A.; Lago, P.; Muccini, H.; Proper, E.; Lankhorst, M.; Schoenherr, M.

    2011-01-01

    The state of the practice in enterprise and software architecture learnt that relevant architectural aspects should be illustrated in multiple views, targeting the various concerns of different stakeholders. This has been expressed a.o. in the ISO/IEC 42010 Standard on architecture descriptions. In

  5. Malignant lymphoma in african lions (panthera leo).

    Science.gov (United States)

    Harrison, T M; McKnight, C A; Sikarskie, J G; Kitchell, B E; Garner, M M; Raymond, J T; Fitzgerald, S D; Valli, V E; Agnew, D; Kiupel, M

    2010-09-01

    Malignant lymphoma has become an increasingly recognized problem in African lions (Panthera leo). Eleven African lions (9 male and 2 female) with clinical signs and gross and microscopic lesions of malignant lymphoma were evaluated in this study. All animals were older adults, ranging in age from 14 to 19 years. Immunohistochemically, 10 of the 11 lions had T-cell lymphomas (CD3(+), CD79a(-)), and 1 lion was diagnosed with a B-cell lymphoma (CD3(-), CD79a(+)). The spleen appeared to be the primary site of neoplastic growth in all T-cell lymphomas, with involvement of the liver (6/11) and regional lymph nodes (5/11) also commonly observed. The B-cell lymphoma affected the peripheral lymph nodes, liver, and spleen. According to the current veterinary and human World Health Organization classification of hematopoietic neoplasms, T-cell lymphoma subtypes included peripheral T-cell lymphoma (4/11), precursor (acute) T-cell lymphoblastic lymphoma/leukemia (2/11), chronic T-cell lymphocytic lymphoma/leukemia (3/11), and T-zone lymphoma (1/11). The single B-cell lymphoma subtype was consistent with diffuse large B-cell lymphoma. Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) testing by immunohistochemistry on sections of malignant lymphoma was negative for all 11 lions. One lion was seropositive for FeLV. In contrast to domestic and exotic cats, in which B-cell lymphomas are more common than T-cell lymphomas, African lions in this study had malignant lymphomas that were primarily of T-cell origin. Neither FeLV nor FIV, important causes of malignant lymphoma in domestic cats, seems to be significant in the pathogenesis of malignant lymphoma in African lions.

  6. Empowerment Zones and Enterprise Districts - Volusia County Enterprise Zones

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Florida's Enterprise Zone Program encourages economic growth and investment in distressed areas by offering tax advantages and incentives to businesses that are...

  7. Enterprise Android programming Android database applications for the enterprise

    CERN Document Server

    Mednieks, Zigurd; Dornin, Laird; Pan, Zane

    2013-01-01

    The definitive guide to building data-driven Android applications for enterprise systems Android devices represent a rapidly growing share of the mobile device market. With the release of Android 4, they are moving beyond consumer applications into corporate/enterprise use. Developers who want to start building data-driven Android applications that integrate with enterprise systems will learn how with this book. In the tradition of Wrox Professional guides, it thoroughly covers sharing and displaying data, transmitting data to enterprise applications, and much more. Shows Android developers w

  8. Performance Monitoring Enterprise Applications with the BlackBird System

    Science.gov (United States)

    Germano, João P.; da Silva, Alberto Rodrigues; Silva, Fernando M.

    This work describes the BlackBird system, which is an analysis and monitoring service for data-intensive enterprise applications, without restrictions on the targeted architecture or employed technologies. A case study is presented for the monitoring of Billing applications from Vodafone Portugal. Monitoring systems are an essential tool for the effective management of Enterprise Applications and the attainment of the demanding service level agreements imposed to these applications. However, due to the increasing complexity and diversity of these applications, adequate monitoring systems are rarely available. The BlackBird monitoring system is able to interact with these applications through different technologies employed by the Monitored Application, and is able to produce Metrics regarding the application service level goals. The BlackBird system can be specified using a set of pre-defined Configuration Objects, allowing it to be extensible and adaptable for applications with different architectures.

  9. Architectural Contestation

    NARCIS (Netherlands)

    Merle, J.

    2012-01-01

    This dissertation addresses the reductive reading of Georges Bataille's work done within the field of architectural criticism and theory which tends to set aside the fundamental ‘broken’ totality of Bataille's oeuvre and also to narrowly interpret it as a mere critique of architectural form,

  10. Architecture Sustainability

    NARCIS (Netherlands)

    Avgeriou, Paris; Stal, Michael; Hilliard, Rich

    2013-01-01

    Software architecture is the foundation of software system development, encompassing a system's architects' and stakeholders' strategic decisions. A special issue of IEEE Software is intended to raise awareness of architecture sustainability issues and increase interest and work in the area. The

  11. Memory architecture

    NARCIS (Netherlands)

    2012-01-01

    A memory architecture is presented. The memory architecture comprises a first memory and a second memory. The first memory has at least a bank with a first width addressable by a single address. The second memory has a plurality of banks of a second width, said banks being addressable by components

  12. Architectural Narratives

    DEFF Research Database (Denmark)

    Kiib, Hans

    2010-01-01

    a functional framework for these concepts, but tries increasingly to endow the main idea of the cultural project with a spatially aesthetic expression - a shift towards “experience architecture.” A great number of these projects typically recycle and reinterpret narratives related to historical buildings......In this essay, I focus on the combination of programs and the architecture of cultural projects that have emerged within the last few years. These projects are characterized as “hybrid cultural projects,” because they intend to combine experience with entertainment, play, and learning. This essay...... and architectural heritage; another group tries to embed new performative technologies in expressive architectural representation. Finally, this essay provides a theoretical framework for the analysis of the political rationales of these projects and for the architectural representation bridges the gap between...

  13. How I treat double-hit lymphoma.

    Science.gov (United States)

    Friedberg, Jonathan W

    2017-08-03

    The 2016 revision of the World Health Organization (WHO) classification for lymphoma has included a new category of lymphoma, separate from diffuse large B-cell lymphoma, termed high-grade B-cell lymphoma with translocations involving myc and bcl-2 or bcl-6 . These lymphomas, which occur in hit lymphomas (or triple-hit lymphomas if all 3 rearrangements are present). It is important to differentiate these lymphomas from the larger group of double-expressor lymphomas, which have increased expression of MYC and BCL-2 and/or BCL-6 by immunohistochemistry, by using variable cutoff percentages to define positivity. Patients with double-hit lymphomas have a poor prognosis when treated with standard chemoimmunotherapy and have increased risk of central nervous system involvement and progression. Double-hit lymphomas may arise as a consequence of the transformation of the underlying indolent lymphoma. There are no published prospective trials in double-hit lymphoma, however retrospective studies strongly suggest that aggressive induction regimens may confer a superior outcome. In this article, I review my approach to the evaluation and treatment of double-hit lymphoma, with an eye toward future clinical trials incorporating rational targeted agents into the therapeutic armamentarium. © 2017 by The American Society of Hematology.

  14. 78 FR 48468 - Hewlett Packard Company, Hewlett Packard Enterprise Business Unit, EG HP Storage, Enterprise...

    Science.gov (United States)

    2013-08-08

    ..., Hewlett Packard Enterprise Business Unit, EG HP Storage, Enterprise Storage, Servers and Networking Storage, APP Management, Research and Development Group, Andover, Massachusetts; Notice of Investigation... Enterprise Business Unit, EG HP Storage, Enterprise Storage, Servers and Networking Storage Division, APP...

  15. Follicular non-Hodgkin's lymphoma

    International Nuclear Information System (INIS)

    Hayashi, D.; Lee, J.C.; Devenney-Cakir, B.; Zaim, S.; Ounadjela, S.; Solal-Celigny, P.; Juweid, M.; Guermazi, A.

    2010-01-01

    Follicular non-Hodgkin's lymphoma (NHL) is a unique subtype of NHL, which is indolent, incurable with a high prevalence of residual mass after treatment, and may transform to more aggressive NHL. The aim of this review is to (1) describe the histological and flow cytometry characteristics of follicular NHL; (2) introduce the Follicular Lymphoma International Prognostic Index 2 (FLIPI-2), which allows better treatment selection and patient stratification for clinical trials; (3) illustrate the classic and atypical ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and positron-emission tomography (PET)/CT appearance of follicular NHL; and (4) characterize the appearance of nodal and extranodal follicular NHL with pathological correlation. Imaging is essential in every step of the management of patients with follicular lymphoma. Overall survival is improved with better predictive tools and new targeted biological therapies. Radiologists should be aware of possible active residual mass, indolent recurrence, transformation, and association with other primary cancers in patients treated for follicular lymphoma.

  16. Primary intracerebral lymphoma: Case report

    Directory of Open Access Journals (Sweden)

    Olcay Eser

    2012-09-01

    Full Text Available We describe a case of primary central nervous lymphoma (PCNSL that may be confused with magnetic resonance imaging (MRI findings of high grade glioma. Primary central nervous lymphoma is a rare tumour and it account for 0.3-3% of intracranial tumours. A 61 year’s old woman was admitted to our clinic with a severe headache, vomiting, left hemiparesia and transient loss of consciousness. Primary central nervous lymphoma may show various biological and radiological characteristics. We herein emphasized being confused with MRI findings of PCNSL and high grade glioma. J Clin Exp Invest 2012; 3 (3: 409-411Key words: Primary central nervous lymphoma, high grade glioma, B-cell, diagnosis

  17. ClouNS - A Cloud-native Application Reference Model for Enterprise Architects

    OpenAIRE

    Kratzke, Nane; Peinl, René

    2017-01-01

    The capability to operate cloud-native applications can generate enormous business growth and value. But enterprise architects should be aware that cloud-native applications are vulnerable to vendor lock-in. We investigated cloud-native application design principles, public cloud service providers, and industrial cloud standards. All results indicate that most cloud service categories seem to foster vendor lock-in situations which might be especially problematic for enterprise architectures. ...

  18. Grand Challenges of Enterprise Integration

    Energy Technology Data Exchange (ETDEWEB)

    Brosey, W.D; Neal, R.E.; Marks, D.

    2001-04-01

    Enterprise Integration connects and combines people, processes, systems, and technologies to ensure that the right people and the right processes have the right information and the right resources at the right time. A consensus roadmap for Technologies for Enterprise Integration was created as part of an industry/government/academia partnership in the Integrated Manufacturing Technology Initiative (IMTI). Two of the grand challenges identified by the roadmapping effort will be addressed here--Customer Responsive Enterprises and Totally Connected Enterprises. Each of these challenges is briefly discussed as to the current state of industry and the future vision as developed in the roadmap.

  19. Crisis management in metallurgical enterprises

    Directory of Open Access Journals (Sweden)

    B. Gajdzik

    2014-07-01

    Full Text Available On the basis of report analysis which presents situation in metallurgical sector after 2008 the range of changes implemented in management of metallurgical enterprises was characterised. A definition approach to crisis management was suggested as the process when the enterprise is managed during the breakdown period in market condition of the economy in the way directed towards preventing the negative effects of crisis inside enterprises. The publication presents the key aspects of enterprise management in the period of collapse of the balance between the supply and demand on the metallurgical market.

  20. Army Healthcare Enterprise Management System

    National Research Council Canada - National Science Library

    2001-01-01

    .... The complaint alleged that the Army Healthcare Enterprise Management System was not properly competed, potential conflicts of interest existed, and possible contract performance problems existed...

  1. Lymphoma in pregnancy

    International Nuclear Information System (INIS)

    Ballova, V.

    2016-01-01

    The diagnosis of malignant lymphoma during pregnancy is always a challenging situation, as for the patient a her family as well as for the whole medical team. Medical and communication skills are crucial in this situation. Interdisciplinary approach and a close cooperation between oncologist, obstetrician and neonatologist are equally important. The diagnosis of malignant potentially lethal disease and the need of treatment during pregnancy raise concerns about the life of mother if treatment was delayed and at the same time concerns about adverse fetal outcomes. This gives raise dilemmas at the therapeutical, ethical, moral and social levels. The patient must be included in the decisional process and the cultural as well as the religious aspects must be taken into account. (author)

  2. Localized folicular lymphomas

    International Nuclear Information System (INIS)

    Soubeyran, P.; Eghbali, H.; Bonichon, F.; Coindre, J.M.; Richaud, P.; Hoerni, B.

    1988-01-01

    From 1966 to 1985, 103 patients with a localized follicular lymphoma were treated at the Fondation Bergonie. Clinical staging was performed using, after physical examination, chest X-rays, bipedal lymphangiography and unilateral bone marrow biopsy (BMB). The patients were then treated by radiotherapy with or without chemotherapy. Overall survival (OS) at 5 and 10 years is 69 and 56.3%, respectively. Relapse-free survival (RFS) is 53.7 and 49%. Unifactorial analysis shows three prognostic parameters to be independently significant in terms of OS: age, stage and B symptons. In terms of RFS, only 2 factors are significant: age and B symptons. Multivariate analysis (Cox model) shows that age is a more important prognostic factor than stage. 40 refs.; 3 figs.; 3 tabs

  3. Enterprise wide transparent information access

    International Nuclear Information System (INIS)

    Brown, J.

    1995-05-01

    The information management needs of the Department of Energy (DOE) represents a fertile domain for the development of highly sophisticated yet intuitive enterprise-wide computing solutions. These solutions must support business operations, research agendas, technology development efforts, decision support, and other application areas with a user base ranging from technical staff to the highest levels of management. One area of primary interest is in the Environmental Restoration and Waste Management Branch of DOE. In this arena, the issue of tracking and managing nuclear waste related to the long legacy of prior defense production and research programs is one of high visibility and great concern. The Tank Waste Information Network System (TWINS) application has been created by the Pacific Northwest Laboratory (PNL) for the DOE to assist in managing and accessing the information related to this mission. The TWINS solution addresses many of the technical issues faced by other efforts to provide integrated information access to a wide variety of stakeholders. TWINS provides secure transparent access to distributed heterogeneous multimedia information sources from around the DOE complex. The users interact with the information through a consistent user interface that presents the desired data in a common format regardless of the structure of the source information. The solutions developed by the TWINS project represent an integration of several technologies and products that can be applied to other mission areas within DOE and other government agencies. These solutions are now being applied to public and private sector problem domains as well. The successful integration and inter-operation of both commercial and custom modules into a flexible and extensible information architecture will help ensure that new problems facing DOE and other clients can be addressed more rapidly in the future by re-use of existing tools and techniques proven viable through the TWINS efforts

  4. Therapy of non-Hodgkin's lymphoma

    International Nuclear Information System (INIS)

    Coffey, J.; Hodgson, D.C.; Gospodarowicz, M.K.

    2003-01-01

    Non-Hodgkin's lymphomas are a heterogeneous group of malignancies of the lymphoid system. The exact etiology for most lymphomas has not been determined, but both viral and bacterial infections have been shown to be important etiologic factors. The WHO classification of hematopoietic and lymphoid tumours classifies lymphomas into B-cell and T-cell neoplasms. B-cell lymphomas account for more than 85% of all lymphomas. The Ann Arbor staging classification has been adopted by the AJCC and UICC as a standard for classifying extent of anatomic disease. The two most common histologic disease entities are follicular lymphomas and diffuse large B-cell lymphomas. The management of follicular lymphomas is used as a paradigm for the management of all indolent lymphomas. Radiation therapy is used for stage I and II disease, while alkylating agent chemotherapy, immunotherapy and radioimmunotherapy are most frequently used in stage III and IV disease that requires treatment. Most patients with follicular lymphoma enjoy prolonged survival, but at present there is no evidence that those with stage III and IV follicular lymphoma can be cured. Diffuse large B-cell lymphomas serve as a paradigm for treating aggressive lymphomas. Stage I and II diffuse large cell lymphomas are generally treated with combined modality therapy with doxorubicin-based chemotherapy followed by involved field radiation therapy, while those with stage III and IV disease are treated with chemotherapy alone. Patients who fail initial management are treated with further chemotherapy. High-dose chemotherapy with stem cell rescue has been shown to be particularly effective as salvage treatment for diffuse large cell lymphomas. The management of a heterogeneous group of primary extranodal lymphomas in general follows the above treatment principles, with additional treatment being required for those with a high risk of CNS failures, or involvement of contralateral paired organs. The management of MALT lymphomas

  5. Targeted immunotherapy in Hodgkin lymphoma

    DEFF Research Database (Denmark)

    Hutchings, Martin

    2015-01-01

    In this issue of Blood, Rothe et al introduce a new principle of targeted Hodgkin lymphoma (HL) immunotherapy in their report from a phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13.......In this issue of Blood, Rothe et al introduce a new principle of targeted Hodgkin lymphoma (HL) immunotherapy in their report from a phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13....

  6. An introduction to USITC enterprise analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ostic, J.K.

    1997-10-01

    The United States Integrated Textile Complex (USITC) consists of fiber, textile, apparel, and retail firms who manufacture and distribute natural and synthetic fiber products. In today`s competitive global economy, USITC companies who team together to form supply chains require relationships which promote responsiveness to consumer demand, encourage business partnerships, and make effective use of resources. These supply chains, or pipelines, are being analyzed to improve time and cost performance. Enterprise analysis is the application of analysis methods and simulation tools to predict integrated performance of these pipelines. Through the use of scenario analysis, various alternatives in pipeline coordination and configuration can be assessed. Simply put, the end result is to design the pipeline so that the product the customer demands is delivered, in the right place, at the right time. In September 1996, industrial participants of the Demand Activated Manufacturing Architecture (DAMA) project completed the Phase 1 pipeline analysis study. The analysis identified opportunities to improve productivity and efficiency among five supply chain members, and proposed a generic modeling architecture and methodology that, if implemented, would identify actions necessary to improve supply-chain coordination among its members. The architecture and methodology are being pursued during the Phase 2 analysis, which is scheduled to be completed by the end of FY 1997. The goal of the Phase 2 analysis is to propose actionable recommendations to supply-chain members leading to a reduction of pipeline lead-time by 50%.

  7. Enterprise Mac Administrator's Guide

    CERN Document Server

    Edge, Charles; Hunter, Beau

    2009-01-01

    Charles Edge, Zack Smith, and Beau Hunter provide detailed explanations of the technology required for large-scale Mac OS X deployments and show you how to integrate it with other operating systems and applications. Enterprise Mac Administrator's Guide addresses the growing size and spread of Mac OS X deployments in corporations and institutions worldwide. In some cases, this is due to the growth of traditional Mac environments, but for the most part it has to do with "switcher" campaigns, where Windows and/or Linux environments are migrating to Mac OS X. However, there is a steep cu

  8. Enterprise Mac Managed Preferences

    CERN Document Server

    Marczak, Edward

    2010-01-01

    Many systems administrators on the Mac need a way to manage machine configuration after initial setup and deployment. Apple's Managed Preferences system (also known as MCX) is under-documented, often misunderstood, and sometimes outright unknown by sys admins. MCX is usually deployed in conjunction with an OS X server, but it can also be used in Windows environments or where no dedicated server exists at all. Enterprise Mac Managed Preferences is the definitive guide to Apple's Managed Client technology. With this book, you'll get the following: * An example-driven guide to Mac OS X Managed Pr

  9. Upgrading Enterprise Search

    Energy Technology Data Exchange (ETDEWEB)

    McDunn, R

    2005-04-28

    This presentation will describe the process we went through this past year to upgrade our enterprise search tool from a very old version of Inktomi to the latest version of Verity Ultraseek. We started with requirements gathering and then compared requirements against several available products to determine which product to choose. After purchasing the product, we worked through several defined phases of implementation and customization, with initial rollout late January 2004. Finally, we will show you where we are today and describe future search plans.

  10. Enterprise risk management

    Energy Technology Data Exchange (ETDEWEB)

    Eaton, C. [Enbridge, Calgary, AB (Canada)

    2015-07-01

    Enterprise risk management (ERM) is a relative new, holistic and strategic approach for managing risks in modern organizations. ERM builds on and extends traditional risk management (RM). Risk is the effect of uncertainty on objectives - positive and/or negative. Risk management is a set of practices used to understand and address risk. ERM is a form of RM that emphasizes risk aggregation and integration. Risk aggregation is combining individual risks into categories ({sup r}olled up{sup )}. risk integration is embedding RM into organizational contexts ({sup b}uilt in{sup )}.

  11. Camel enterprise integration cookbook

    CERN Document Server

    Cranton, Scott

    2013-01-01

    This book is written in a Cookbook style with short recipes showing developers how to effectively implement EIP without breaking everything in the process. It is concise and to the point, and it helps developers get their data flowing between different components without the need to read through page upon page of theory, while also enabling the reader to learn how to create exciting new projects.Camel Enterprise Integration Cookbook is intended for developers who have some familiarity with Apache Camel and who want a quick lookup reference to practical, proven tips on how to perform common tas

  12. Molecular Pathogenesis of MALT Lymphoma

    Directory of Open Access Journals (Sweden)

    Katharina Troppan

    2015-01-01

    Full Text Available Approximately 8% of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT, also known as MALT lymphoma, which was first described in 1983 by Isaacson and Wright. MALT lymphomas arise at a wide range of different extranodal sites, with the highest frequency in the stomach, followed by lung, ocular adnexa, and thyroid, and with a low percentage in the small intestine. Interestingly, at least 3 different, apparently site-specific, chromosomal translocations and missense and frameshift mutations, all pathway-related genes affecting the NF-κB signal, have been implicated in the development and progression of MALT lymphoma. However, these genetic abnormalities alone are not sufficient for malignant transformation. There is now increasing evidence suggesting that the oncogenic product of translocation cooperates with immunological stimulation in oncogenesis, that is, the association with chronic bacterial infection or autoaggressive process. This review mainly discusses MALT lymphomas in terms of their genetic aberration and association with chronic infections and summarizes recent advances in their molecular pathogenesis.

  13. Treatment results of localized gastric lymphoma

    International Nuclear Information System (INIS)

    Abe, Tatsuyuki; Gomi, Hiromichi; Sakaino, Shinjiro; Nakajima, Yasuo

    2008-01-01

    Between 2000 and 2007, 17 patients with localized gastric lymphoma (10 mucosa-associated lymphoid tissue lymphomas and 7 diffuse large B-cell lymphomas) were treated with radiotherapy alone or doxorubicin-based chemotherapy followed by radiotherapy. Radiation dose of mucosa-associated lymphoid tissue (MALT) lymphoma was 30 Gy with a daily fraction size of 1.5 Gy. Sixteen patients achieved complete remission and the 5-year overall survival of MALT lymphoma and diffuse large B-cell lymphoma (DLBCL) were 100% and 87%, respectively. No gastric perforation and hemorrhage were noticed. Using AP/LR 2-port radiotherapy markedly decreased the liver dose. (author)

  14. Multi Agent Systems to Set Up Virtual Enterprises

    Directory of Open Access Journals (Sweden)

    Catalin Lupu

    2008-01-01

    Full Text Available This work presents a model of organizing moreenterprises into a virtual or a web enterprise. To constitutevirtual enterprises multiagent systems are utilized.In this sense the following are to be considered:elaborating a model to constitute the virtual enterprise, theimplementation of a multiagent system based on this modeland the testing and evaluation of the system performances,comparing them with more classic types of realization.In this paper, we describe how the multi-agentarchitecture can be used to support Virtual Enterprises(VE. We have focused on understanding how aVE is formedand, in particular, how the partners of a VE are selected. Wetryto analyse this scenario in the form of an AgentInteraction Protocol (AIP and then discuss how the multiagentarchitecrure can be used to support this process.Our working definition of a VE is: a team of partners thatcollaborate to achieve a specific goal. The partners may behuman beings, organisations or software agents. We believethat software agents, hereafter referred to as agents, are asuitable means of representing the partners of a VE. Oneimportant reason is that by representing the partners of aVE as agents and by delegating agents to look for the nextVE and conduct the negotiation on behalf of the partners, thepartners would then have the time to do the actual workrequired in the current VE.At the end of the paper we will present an experimentalsystem for the architecture of a virtual enterprise.

  15. The use of software agents and distributed objects to integrate enterprises: Compatible or competing technologies?

    Energy Technology Data Exchange (ETDEWEB)

    Pancerella, C.M.

    1998-04-01

    Distributed object and software agent technologies are two integration methods for connecting enterprises. The two technologies have overlapping goals--interoperability and architectural support for integrating software components--though to date little or no integration of the two technologies has been made at the enterprise level. The primary difference between these two technologies is that distributed object technologies focus on the problems inherent in connecting distributed heterogeneous systems whereas software agent technologies focus on the problems involved with coordination and knowledge exchange across domain boundaries. This paper addresses the integration of these technologies in support of enterprise integration across organizational and geographic boundaries. The authors discuss enterprise integration issues, review their experiences with both technologies, and make recommendations for future work. Neither technology is a panacea. Good software engineering techniques must be applied to integrate an enterprise because scalability and a distributed software development team are realities.

  16. Architectural technology

    DEFF Research Database (Denmark)

    2005-01-01

    The booklet offers an overall introduction to the Institute of Architectural Technology and its projects and activities, and an invitation to the reader to contact the institute or the individual researcher for further information. The research, which takes place at the Institute of Architectural...... Technology at the Roayl Danish Academy of Fine Arts, School of Architecture, reflects a spread between strategic, goal-oriented pilot projects, commissioned by a ministry, a fund or a private company, and on the other hand projects which originate from strong personal interests and enthusiasm of individual...

  17. Systemic Architecture

    DEFF Research Database (Denmark)

    Poletto, Marco; Pasquero, Claudia

    -up or tactical design, behavioural space and the boundary of the natural and the artificial realms within the city and architecture. A new kind of "real-time world-city" is illustrated in the form of an operational design manual for the assemblage of proto-architectures, the incubation of proto-gardens...... and the coding of proto-interfaces. These prototypes of machinic architecture materialize as synthetic hybrids embedded with biological life (proto-gardens), computational power, behavioural responsiveness (cyber-gardens), spatial articulation (coMachines and fibrous structures), remote sensing (FUNclouds...

  18. Humanizing Architecture

    DEFF Research Database (Denmark)

    Toft, Tanya Søndergaard

    2015-01-01

    The article proposes the urban digital gallery as an opportunity to explore the relationship between ‘human’ and ‘technology,’ through the programming of media architecture. It takes a curatorial perspective when proposing an ontological shift from considering media facades as visual spectacles...... agency and a sense of being by way of dematerializing architecture. This is achieved by way of programming the symbolic to provide new emotional realizations and situations of enlightenment in the public audience. This reflects a greater potential to humanize the digital in media architecture....

  19. A Case of Diffuse Large B-Cell Lymphoma Mimicking Primary Effusion Lymphoma-Like Lymphoma

    Directory of Open Access Journals (Sweden)

    Daisuke Usuda

    2017-11-01

    Full Text Available A 93-year-old female was transferred to the emergency ward of our hospital due to disturbance of consciousness and hypotension. Computed tomography showed bilateral pleural and pericardial effusion without evidence of tumor masses or lymphadenopathy. Cytodiagnosis of pleural effusion revealed proliferation of atypical lymphoid-like cells with pan-B surface markers. We suspected primary effusion lymphoma-like lymphoma; however, the monoclonality of these cells was not confirmed. Cytodiagnosis of bone marrow revealed lymphoma cells with monoclonal B-cell markers. These findings prompted a diagnosis of diffuse large B-cell lymphoma with bone marrow invasion. In the case of pericardial or pleural effusion, clinicians should consider carefully both hematological malignancy and its classification.

  20. The role of enterprise systems in supply chain networks: a taxonomy of supply chain strategies

    DEFF Research Database (Denmark)

    Møller, Charles

    2006-01-01

    in the supply chain and to choose the right supply chain strategy. The work is based on a comprehensive study of the Supply Chain Management (SCM) and Enterprise Resource Planning (ERP) literature and the study suggests that there is an emerging new research potential for Enterprise Systems (ES) in the supply......This paper proposes a taxonomy for supply chain integration strategies. The taxonomy is based on the contingencies of supply chain network coupling and the Extended Enterprise Systems (EES) architecture in the supply chain. The purpose of this model is to map the portfolio of relations...

  1. Hodgkin's lymphoma arising in a case of mycosis fungoides: An unusual association

    Directory of Open Access Journals (Sweden)

    Preeti Sharma

    2018-01-01

    Full Text Available Mycosis fungoides is a cutaneous T-cell lymphoma with a high risk for developing secondary malignancies, especially B-cell lymphoproliferative disorders. About 40 cases of Hodgkin's lymphoma associated with mycosis fungoides have been reported in literature till date. We report a case of a 35-year-old gentleman who presented with intensely itchy reddish lesions all over the body. Multiple skin biopsies taken from the lesions on scalp and back confirmed the clinical diagnosis of mycosis fungoides. While on treatment, he presented with multiple bilateral cervical, axillary and inguinal lymphadenopathy 9 years after the primary diagnosis of mycosis fungoides. Excision biopsy of a cervical lymph node revealed partial effacement of architecture by a tumor comprising polymorphous background. Histopathology and immunohistochemistry revealed a diagnosis of Hodgkin's lymphoma - nodular sclerosis subtype. The patient was started on chemotherapy for stage IV Hodgkin's lymphoma. Our case emphasizes the importance of keeping secondary Hodgkin's lymphoma in mind while dealing with a patient of mycosis fungoides. Our case immunohistochemically supports the distinct etiopathogenesis of Epstein–Barr virus-negative Hodgkin's lymphoma vis-à-vis cutaneous mycosis fungoides.

  2. Carfilzomib With or Without Rituximab in the Treatment of Waldenstrom Macroglobulinemia or Marginal Zone Lymphoma

    Science.gov (United States)

    2018-02-05

    Marginal Zone Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Waldenstrom Macroglobulinemia; Refractory Marginal Zone Lymphoma; Refractory Waldenstrom Macroglobulinemia; Waldenstrom Macroglobulinemia

  3. Architectural Theatricality

    DEFF Research Database (Denmark)

    Tvedebrink, Tenna Doktor Olsen

    environments and a knowledge gap therefore exists in present hospital designs. Consequently, the purpose of this thesis has been to investigate if any research-based knowledge exist supporting the hypothesis that the interior architectural qualities of eating environments influence patient food intake, health...... and well-being, as well as outline a set of basic design principles ‘predicting’ the future interior architectural qualities of patient eating environments. Methodologically the thesis is based on an explorative study employing an abductive approach and hermeneutic-interpretative strategy utilizing tactics...... and food intake, as well as a series of references exist linking the interior architectural qualities of healthcare environments with the health and wellbeing of patients. On the basis of these findings, the thesis presents the concept of Architectural Theatricality as well as a set of design principles...

  4. Virtual Enterprise: Transforming Entrepreneurship Education

    Science.gov (United States)

    Borgese, Anthony

    2011-01-01

    Entrepreneurship education is ripe for utilizing experiential learning methods. Experiential methods are best learned when there is constant immersion into the subject matter. One such transformative learning methodology is Virtual Enterprise (VE). Virtual Enterprise is a multi-faceted, experiential learning methodology disseminated by the City…

  5. Shaping the Enterprise By Design

    DEFF Research Database (Denmark)

    Gøtze, John; Guenther, Milan

    2017-01-01

    Too often, ambitious service design initiatives that require complex enterprises to change fall short of delivering on their intended outcomes.......Too often, ambitious service design initiatives that require complex enterprises to change fall short of delivering on their intended outcomes....

  6. Participatory Governance in Social Enterprise

    DEFF Research Database (Denmark)

    Pestoff, Victor Alexis; Hulgård, Lars

    2016-01-01

    This paper emphasizes the importance of participative governance in the study of social enterprise. Furthermore, it argues that social enterprise must be analyzed through a multi-dimensional perspective. The EMES approach is based on three dimensions emphasizing the social, economic, and politica...

  7. New Generation of Social Enterprises

    DEFF Research Database (Denmark)

    Persson, H. Thomas R.; Hafen, Niklas

    Teater Psykbryt is a Work-Integration Social Enterprise (WISE) in Malmö with the aim to create jobs for long-termed unemployed individuals due to different forms of mental illness using improvised theater. The enterprise was established in the spring of 2013 in the legal form of a cooperative eco...

  8. Strategy development marketing commercial enterprise

    OpenAIRE

    Shatalov D. S.; Hamidova O. M.

    2016-01-01

    in the scientific article the necessity of development and implementation of marketing strategies in the activity of any commercial enterprise, we give a meaningful description of the concept of «marketing strategy» and develop requirements for the selection strategy of trade enterprise.

  9. ENTERPRISE RESTRUCTURING AIM AND TYPES

    Directory of Open Access Journals (Sweden)

    S. P. Baranenko

    2011-01-01

    Full Text Available Enterprise restructuring is aimed at adapting it to market conditions and improving its competitiveness through selection of most effective model of using material, technical, technological, organizational, commercial, economical, financial, tax-related and other resources with due account of the demand. Restructuring classification signs and types as well as restructuring aims specific for industrial enterprises are provided for.

  10. Enterprise Mobile Tracking and Reminder System: MAE

    Directory of Open Access Journals (Sweden)

    Cheah Huei Yoong

    2012-07-01

    Full Text Available Mobile phones have made significant improvements from providing voice communications to advanced features such as camera, GPS, Wi-Fi, SMS, voice recognition, Internet surfing, and touch screen. This paper presents an enterprise mobile tracking and reminder system (MAE that enables the elderly to have a better elder-care experience. The high-level architecture and major software algorithms especially the tracking in Android phones and SMS functions in server are described. The analysis of data captured and performance study of the server are discussed. In order to show the effectiveness of MAE, a pilot test was carried out with a retirement village in Singapore and the feedback from the elderly was evaluated. Generally, most comments received from the elderly were positive.

  11. Information Technology: Architecture Needed to Guide Modernization of DoD's Financial Operations

    National Research Council Canada - National Science Library

    2001-01-01

    .... Effectively managing such a large and complex endeavor requires, among other things, a well-defined and enforced blueprint for operational and technological change, commonly referred to as an enterprise architecture...

  12. Composite Lymphoma : EBV-positive Classic Hodgkin Lymphoma and Peripheral T-cell Lymphoma A Case Report

    NARCIS (Netherlands)

    Gualco, Gabriela; Chioato, Lucimara; Van Den Berg, Anke; Weiss, Lawrence M.; Bacchi, Carlos E.

    Composite lymphomas are rare and defined as hematopoietic neoplasms with more than I malignant lymphomatous clone showing different phenotypic features. Of all possible combinations between non-Hodgkin lymphomas, B cell or T cell, and Hodgkin lymphoma, the least frequent are the ones combining

  13. SOA based Data Architecture for HTML5 Web Applications

    Directory of Open Access Journals (Sweden)

    Catalin STRIMBEI

    2013-01-01

    Full Text Available Web Services based architectures have already been established as the preferred way to integrate SOA specific components, from the front-end to the back-end business services. One of the key elements of such architecture are data-based or entity services. In this context, SDO standard and SDO related technologies have been confirmed as a possible approach to aggregate such enterprise-wide federation of data services, mainly backed by database servers, but not limited to them. In the followings, we will discuss an architectural purpose based on SDO approach to seamlessly integrate presentation and data services within an enterprise SOA context. This way we will outline the benefits of a common end-to-end data integration strategy. Also, we will try to argue that using HTML5 based clients as front end services in conjunction with SDO data services could be an effective strategy to adopt the mobile computing in the enterprise context.

  14. Treatment Options for Non-Hodgkin Lymphoma

    Science.gov (United States)

    ... factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery ) and treatment options ... lymphoma may come back as indolent lymphoma. Treatment Option Overview Key Points There are different types of ...

  15. General Information about Adult Hodgkin Lymphoma

    Science.gov (United States)

    ... Lymphocyte-rich classical Hodgkin lymphoma. Age, gender, and Epstein-Barr infection can affect the risk of adult Hodgkin lymphoma. Anything that increases your risk of getting a disease is called a risk factor . Having a risk ...

  16. Parotid lymphomas - clinical and computed tomogrphic imaging ...

    African Journals Online (AJOL)

    Parotid lymphomas - clinical and computed tomogrphic imaging features. ... South African Journal of Surgery ... Lymphoma has a clinical presentation similar ... CT scanning is a useful adjunctive investigation to determine the site and extent of ...

  17. Everolimus and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma

    Science.gov (United States)

    2018-02-07

    Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Splenic Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia

  18. Enterprise Reference Library

    Science.gov (United States)

    Bickham, Grandin; Saile, Lynn; Havelka, Jacque; Fitts, Mary

    2011-01-01

    Introduction: Johnson Space Center (JSC) offers two extensive libraries that contain journals, research literature and electronic resources. Searching capabilities are available to those individuals residing onsite or through a librarian s search. Many individuals have rich collections of references, but no mechanisms to share reference libraries across researchers, projects, or directorates exist. Likewise, information regarding which references are provided to which individuals is not available, resulting in duplicate requests, redundant labor costs and associated copying fees. In addition, this tends to limit collaboration between colleagues and promotes the establishment of individual, unshared silos of information The Integrated Medical Model (IMM) team has utilized a centralized reference management tool during the development, test, and operational phases of this project. The Enterprise Reference Library project expands the capabilities developed for IMM to address the above issues and enhance collaboration across JSC. Method: After significant market analysis for a multi-user reference management tool, no available commercial tool was found to meet this need, so a software program was built around a commercial tool, Reference Manager 12 by The Thomson Corporation. A use case approach guided the requirements development phase. The premise of the design is that individuals use their own reference management software and export to SharePoint when their library is incorporated into the Enterprise Reference Library. This results in a searchable user-specific library application. An accompanying share folder will warehouse the electronic full-text articles, which allows the global user community to access full -text articles. Discussion: An enterprise reference library solution can provide a multidisciplinary collection of full text articles. This approach improves efficiency in obtaining and storing reference material while greatly reducing labor, purchasing and

  19. Data Mediation with Enterprise Level Security

    Directory of Open Access Journals (Sweden)

    Kevin E. Foltz

    2017-10-01

    Full Text Available Enterprise Level Security (ELS is an architecture for enabling information sharing with strong security guarantees. It is built upon basic tenets and concepts that shape its component technologies and implementation. One challenge in sharing information is that the source and recipient of the information may use different units, protocols, data formats, or tools to process information. As a result, a transformation of the data is needed before the recipient can use the information. These conversions introduce potential security weaknesses into an ELS system, so an approach for enterprise-wide mediation is required. Methods in common use today, such as a man-in-the-middle (MITM translation and an online mediation service, do not preserve the basic ELS tenets and concepts. This paper examines these existing approaches and compares them with two new approaches designed to preserve ELS security. It looks at the complete picture of security, performance, and ease of implementation, offering a framework for choosing the best mediation approach based on the data sharing context.

  20. An introduction to enterprise modeling and simulation

    Energy Technology Data Exchange (ETDEWEB)

    Ostic, J.K.; Cannon, C.E. [Los Alamos National Lab., NM (United States). Technology Modeling and Analysis Group

    1996-09-01

    As part of an ongoing effort to continuously improve productivity, quality, and efficiency of both industry and Department of Energy enterprises, Los Alamos National Laboratory is investigating various manufacturing and business enterprise simulation methods. A number of enterprise simulation software models are being developed to enable engineering analysis of enterprise activities. In this document the authors define the scope of enterprise modeling and simulation efforts, and review recent work in enterprise simulation at Los Alamos National Laboratory as well as at other industrial, academic, and research institutions. References of enterprise modeling and simulation methods and a glossary of enterprise-related terms are provided.

  1. International Fashion Retailing from an Enterprise Architecture Perspective

    DEFF Research Database (Denmark)

    Tambo, Torben

    2011-01-01

    International retailing of non-food fashion products, as chain stores impose a particular challenge within EA as the same general infrastructure networks, brands, data, business intelligence and applications should work in multiple, semi-compliant geographic regions. Generalised information syste...... international networks of chains encompassing marketing, supply chain, multi-channel concepts, payment systems and loyalty programs. Conclusively directions are set for a deepening of EA within retail....

  2. A Workshop on Analysis and Evaluation of Enterprise Architectures

    Science.gov (United States)

    2010-11-01

    standards that identify EA quality attributes. For example, Control Objectives for Information and related Technology ( COBIT ) identifies • effectiveness...Communications, and Computing for Intelligence, Surveillance, and Re- connaissance CIO Chief Information Officer COBIT Control Objectives for Information and

  3. Adaptation of enterprise architecture efforts to an agile environment

    NARCIS (Netherlands)

    Robin Duijs; Pascal Ravesteijn; Marlies van Steenbergen

    2018-01-01

    From the article: Agile ways of working have become mainstream, with many organisations practising a form of agile. Agile maturity among those organisations differs. In a research conducted by VersionOne Inc. (2016), 82% of the participating organisations stated to be at or below the level of ‘still

  4. Enterprise architecture as tool for managing operational complexity in organizations

    Directory of Open Access Journals (Sweden)

    Martín Dario Arango-Serna

    2014-01-01

    Full Text Available Diferentes tipos de empresas alrededor del mundo, sin importar su tamaño, ni su actividad económica, ni su naturaleza y el capital que manejan, entre otros aspectos, enfrentan en su día a día, retos de diferente índole que deben ser atendidos de manera ágil para poder competir de forma exitosa en un mundo globalizado y que opera bajo entornos altamente dinámicos. En este sentido, cada vez toma mayor relevancia el hecho de que, a nivel del funcionamiento interno, las organizaciones deben estar lo suficientemente preparadas para dar respuesta de forma eficiente, ágil e innovadora a los retos y necesidades que se presentan. Este artículo plantea la importancia que representan las tecnologías de información y el desarrollo de un modelo de arquitectura empresarial, como instrumentos que permiten a las empresas afrontar los retos asociados con la complejidad que se presenta en una organización en su entorno operativo.

  5. Engineering Software for Interoperability through Use of Enterprise Architecture Techniques

    Science.gov (United States)

    2003-03-01

    Response Home/ Business Security . To detect flood conditions (i.e. excess water levels) within the monitored area and alert authorities, as necessary...Response; Fire Detection & Response; and Flood Detection & Response. Functional Area Description Intruder Detection & Response Home/ Business ... Security . To monitor and detect unauthorized entry into the secured area and sound alarms/alert authorities, as necessary. Fire Detection

  6. Health Enterprise Architecture Laboratory (HEAL) | Page 2 | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... world-class training program for health informatics researchers, and a test bed for analyses under low-resource conditions. HEAL will work with public and private, local and international organizations to support practical research projects and internships for graduates, as well as openly accessible educational materials, ...

  7. Gamification and Enterprise Architecture – literature review and case studies

    DEFF Research Database (Denmark)

    Ullerup, Ask; Andreasen, Kristian Emil; Tambo, Torben

    Gamification is a key notion in shaping of future software experience platforms for consumer and business information systems. Gamification has originated from software in the form of computer games and transcended into a design movement for digital experience. Certain parts of gamification are c...... be assessed for process impact, feasibility and governance. The paper demonstrates that the single-most key benefit of gamification is the harvest of data from the situation of the user and the extent to which these data can be brought into business value....

  8. Department of Defense Information Enterprise Architecture Version 1.2

    Science.gov (United States)

    2010-05-07

    Internet Protocol (IP) boundaries of the Global Information Grid (GIG). Outside of these boundaries, the principles still should be considered, but...Capability Portfolio Managers) in managing the overall DoD Information Technology (IT) portfolio. Components will use DoD IEA to strategically... Information Sharing Strategy (May 2007) DoD Information Assurance Policies (DoDD 8500.01E, October 2002) DoD Computing Infrastructure Strategy

  9. Propositions that describe the intended meaning of Enterprise Architecture

    CSIR Research Space (South Africa)

    Mentz, JC

    2014-09-01

    Full Text Available of the definition of terms and fundamental concepts has been continually debated. The ongoing debate is indicative of a lack of universal agreement on EA fundamentals amongst EA researchers and practitioners which, in turn, manifests as a gap in the literature...

  10. Enterprise software architecture and design entities, services, and resources

    CERN Document Server

    Duggan, Dominic

    2012-01-01

    This book fills a gap between high-level overview texts that are often too general and low-level detail oriented technical handbooks that lose sight the "big picture". This book discusses SOA from the low-level perspective of middleware, various XML-based technologies, and basic service design. It also examines broader implications of SOA, particularly where it intersects with business process management and process modeling. Concrete overviews will be provided of the methodologies in those fields, so that students will have a hands-on grasp of how they may be used in the contex

  11. Power Analysis of an Enterprise Wireless Communication Architecture

    Science.gov (United States)

    2017-09-01

    command and control, C2, Internet of Things , IoT, model based systems engineering, MBSE, marine air-ground task force, MAGTF, command control and...Electronics Engineers InTop Integrated Topside IPS Instructions per Second IoT Internet of Things JTNC Joint Tactical Networking Center L-RTac...wireless communications in the military increases the amount of energy needed for missions. The Internet of Things (IoT) movement (Thomas, McPherson, and

  12. Enterprise Management Network Architecture Distributed Knowledge Base Support

    Science.gov (United States)

    1990-11-01

    schemata be distributed? To solve this problem, we defined a user- callable function: distribution-function. This function identifies who the "potential...Artificial Intelligence, Volume 4. Addison-Wesley Publishing Company, Massachusetts, 1989. [4] Bond , A.H., and Gasser, L. Readings in Distributed

  13. Perencanaan Enterprise Architecture Pada Perusahaan Manufaktur PT. Z

    OpenAIRE

    Hartedja, Odwin Viator; Santoso, Leo Willyanto; Rostianingsih, Silvia

    2015-01-01

    PT.Z is a well-known producer and manufacturer of paint in Indonesia with years of experience in paint industry which produce many varieties of paint such as Decorative Coating (water and solvent based), automotive coating, Industrial Coating and Heavy Duty Coating. PT.Z has several subsidiaries all over Indonesia to elevate its product distribution. In the business process, PT.Z applies Information System to support and enhance the overall business. But, the current Information System applie...

  14. Architectural freedom and industrialized architecture

    DEFF Research Database (Denmark)

    Vestergaard, Inge

    2012-01-01

    to explain that architecture can be thought as a complex and diverse design through customization, telling exactly the revitalized storey about the change to a contemporary sustainable and better performing expression in direct relation to the given context. Through the last couple of years we have...... proportions, to organize the process on site choosing either one room wall components or several rooms wall components – either horizontally or vertically. Combined with the seamless joint the playing with these possibilities the new industrialized architecture can deliver variations in choice of solutions...... for retrofit design. If we add the question of the installations e.g. ventilation to this systematic thinking of building technique we get a diverse and functional architecture, thereby creating a new and clearer story telling about new and smart system based thinking behind architectural expression....

  15. Architectural freedom and industrialized architecture

    DEFF Research Database (Denmark)

    Vestergaard, Inge

    2012-01-01

    to explain that architecture can be thought as a complex and diverse design through customization, telling exactly the revitalized storey about the change to a contemporary sustainable and better performing expression in direct relation to the given context. Through the last couple of years we have...... expression in the specific housing area. It is the aim of this article to expand the different design strategies which architects can use – to give the individual project attitudes and designs with architectural quality. Through the customized component production it is possible to choose different...... for retrofit design. If we add the question of the installations e.g. ventilation to this systematic thinking of building technique we get a diverse and functional architecture, thereby creating a new and clearer story telling about new and smart system based thinking behind architectural expression....

  16. Architectural freedom and industrialised architecture

    DEFF Research Database (Denmark)

    Vestergaard, Inge

    2012-01-01

    Architectural freedom and industrialized architecture. Inge Vestergaard, Associate Professor, Cand. Arch. Aarhus School of Architecture, Denmark Noerreport 20, 8000 Aarhus C Telephone +45 89 36 0000 E-mai l inge.vestergaard@aarch.dk Based on the repetitive architecture from the "building boom" 1960...... customization, telling exactly the revitalized storey about the change to a contemporary sustainable and better performed expression in direct relation to the given context. Through the last couple of years we have in Denmark been focusing a more sustainable and low energy building technique, which also include...... to the building physic problems a new industrialized period has started based on light weight elements basically made of wooden structures, faced with different suitable materials meant for individual expression for the specific housing area. It is the purpose of this article to widen up the different design...

  17. Pomalidomide and Dexamethasone in Treating Patients With Relapsed or Refractory Primary Central Nervous System Lymphoma or Newly Diagnosed or Relapsed or Refractory Intraocular Lymphoma

    Science.gov (United States)

    2017-08-28

    B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma; Central Nervous System Lymphoma; Intraocular Lymphoma; Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System; Recurrent Adult Diffuse Large Cell Lymphoma; Retinal Lymphoma

  18. Architectural freedom and industrialised architecture

    DEFF Research Database (Denmark)

    Vestergaard, Inge

    2012-01-01

    to the building physic problems a new industrialized period has started based on light weight elements basically made of wooden structures, faced with different suitable materials meant for individual expression for the specific housing area. It is the purpose of this article to widen up the different design...... to this systematic thinking of the building technique we get a diverse and functional architecture. Creating a new and clearer story telling about new and smart system based thinking behind the architectural expression....

  19. Cure of incurable lymphoma

    International Nuclear Information System (INIS)

    De Nardo, Gerald L.; Sysko, Vladimir V.; De Nardo, Sally J.

    2006-01-01

    The most potent method for augmenting the cytocidal power of monoclonal antibody (MAb) treatment is to conjugate radionuclides to the MAb to deliver systemic radiotherapy (radioimmunotherapy; RIT). The antigen, MAb, and its epitope can make a difference in the performance of the drug. Additionally, the radionuclide, radiochemistry, chelator for radiometals and the linker between the MAb and chelator can have a major influence on the performance of drugs (radiopharmaceuticals) for RIT. Smaller radionuclide carriers, such as antibody fragments and mimics, and those used for pretargeting strategies, have been described and evaluated. All of these changes in the drugs and strategies for RIT have documented potential for improved performance and patient outcomes. RIT is a promising new therapy that should be incorporated into the management of patients with B-cell non-Hodgkin's lymphoma (NHL) soon after these patients have proven incurable. Predictable improvements using better drugs, strategies, and combinations with other drugs seem certain to make RIT integral to the management of patients with NHL, and likely lead to cure of currently incurable NHL

  20. Architectural geometry

    KAUST Repository

    Pottmann, Helmut; Eigensatz, Michael; Vaxman, Amir; Wallner, Johannes

    2014-01-01

    Around 2005 it became apparent in the geometry processing community that freeform architecture contains many problems of a geometric nature to be solved, and many opportunities for optimization which however require geometric understanding. This area of research, which has been called architectural geometry, meanwhile contains a great wealth of individual contributions which are relevant in various fields. For mathematicians, the relation to discrete differential geometry is significant, in particular the integrable system viewpoint. Besides, new application contexts have become available for quite some old-established concepts. Regarding graphics and geometry processing, architectural geometry yields interesting new questions but also new objects, e.g. replacing meshes by other combinatorial arrangements. Numerical optimization plays a major role but in itself would be powerless without geometric understanding. Summing up, architectural geometry has become a rewarding field of study. We here survey the main directions which have been pursued, we show real projects where geometric considerations have played a role, and we outline open problems which we think are significant for the future development of both theory and practice of architectural geometry.