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Sample records for lv lead location

  1. Assessment of the LV-S2 & LV-S3 Stack Sampling Probe Locations for Compliance with ANSI/HPS N13.1-1999

    Energy Technology Data Exchange (ETDEWEB)

    Glissmeyer, John A.; Antonio, Ernest J.; Flaherty, Julia E.; Amidan, Brett G.

    2014-09-30

    This document reports on a series of tests conducted to assess the proposed air sampling locations for the Hanford Tank Waste Treatment and Immobilization Plant (WTP) Group 1-2A exhaust stacks with respect to the applicable criteria regarding the placement of an air sampling probe. The LV-C2, LV-S2, and LV-S3 exhaust stacks were tested together as a group (Test Group 1-2A). This report only covers the results of LV-S2 and LV-S3; LV-C2 will be reported on separately. Federal regulations1 require that a sampling probe be located in the exhaust stack according to the criteria established by the American National Standards Institute/Health Physics Society (ANSI/HPS) N13.1-1999, Sampling and Monitoring Releases of Airborne Radioactive Substances from the Stack and Ducts of Nuclear Facilities. 2 These criteria address the capability of the sampling probe to extract a sample that represents the effluent stream.

  2. Assessment of the LV-C2 Stack Sampling Probe Location for Compliance with ANSI/HPS N13.1-1999

    Energy Technology Data Exchange (ETDEWEB)

    Glissmeyer, John A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Antonio, Ernest J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Flaherty, Julia E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-09-01

    This document reports on a series of tests conducted to assess the proposed air sampling location for the Hanford Tank Waste Treatment and Immobilization Plant (WTP) Low-Activity Waste (LAW) C2V (LV-C2) exhaust stack with respect to the applicable criteria regarding the placement of an air sampling probe. Federal regulations require that a sampling probe be located in the exhaust stack according to the criteria established by the American National Standards Institute/Health Physics Society (ANSI/HPS) N13.1-1999, Sampling and Monitoring Releases of Airborne Radioactive Substances from the Stack and Ducts of Nuclear Facilities. These criteria address the capability of the sampling probe to extract a sample that represents the effluent stream. The tests were conducted on the LV-C2 scale model system. Based on the scale model tests, the location proposed for the air sampling probe in the scale model stack meets the requirements of the ANSI/HPS N13.1-1999 standard for velocity uniformity, flow angle, gas tracer and particle tracer uniformity. Additional velocity uniformity and flow angle tests on the actual stack will be necessary during cold startup to confirm the validity of the scale model results in representing the actual stack.

  3. Assessment of the Group 5-6 (LB C2, LB S2, LV S1) Stack Sampling Probe Locations for Compliance with ANSI/HPS N13.1 1999

    Energy Technology Data Exchange (ETDEWEB)

    Glissmeyer, John A.; Flaherty, Julia E.; Piepel, Gregory F.

    2011-03-11

    This document reports on a series of tests to assess the proposed air sampling locations for the Hanford Tank Waste Treatment and Immobilization Plant (WTP) Group 5-6 exhaust stacks with respect to the applicable criteria regarding the placement of an air sampling probe. The LB-C2, LV-S1, and LB S2 exhaust stacks were tested together as a group (Test Group 5-6) because the common factor in their design is that the last significant flow disturbance upstream of the air sampling probe is a reduction in duct diameter. Federal regulations( ) require that a sampling probe be located in the exhaust stack according to the criteria of the American National Standards Institute/Health Physics Society (ANSI/HPS) N13.1-1999, Sampling and Monitoring Releases of Airborne Radioactive Substances from the Stack and Ducts of Nuclear Facilities. These criteria address the capability of the sampling probe to extract a sample that represents the effluent stream. The testing on scale models of the stacks conducted for this project was part of the River Protection Project—Waste Treatment Plant Support Program under Contract No. DE-AC05-76RL01830 according to the statement of work issued by Bechtel National Inc. (BNI, 24590-QL-SRA-W000-00101, N13.1-1999 Stack Monitor Scale Model Testing and Qualification, Revision 1, 9/12/2007) and Work Authorization 09 of Memorandum of Agreement 24590-QL-HC9-WA49-00001. The internal Pacific Northwest National Laboratory (PNNL) project for this task is 53024, Work for Hanford Contractors Stack Monitoring. The testing described in this document was further guided by the Test Plan Scale Model Testing the Waste Treatment Plant LB-C2, LB-S2, and LV-S1 (Test Group 5-6) Stack Air Sampling Positions (TP-RPP-WTP-594). The tests conducted by PNNL during 2009 and 2010 on the Group 5-6 scale model systems are described in this report. The series of tests consists of various measurements taken over a grid of points in the duct cross-section at the designed sampling

  4. Application of MV/LV Transformers with OLTC for Increasing the PV Hosting Capacity Of LV Grids

    DEFF Research Database (Denmark)

    Hashemi Toghroljerdi, Seyedmostafa; Heckmann, Wolfram; Geibel, Dominik

    2015-01-01

    the operation of OLTC during high PV generation periods are investigated and the methods are applied to an LV feeder with an MV/LV transformer equipped by OLTC located in Felsberg, Germany. The potential interferences between OLTCs and two other overvoltage prevention methods, the demand side management (DSM...

  5. Efficient Control of Active Transformers for Increasing the PV Hosting Capacity of LV Grids

    DEFF Research Database (Denmark)

    Hashemi Toghroljerdi, Seyedmostafa; Østergaard, Jacob; Degner, Thomas

    2016-01-01

    on decreasing the voltage rise along LV feeders, and the potential of active medium voltage to low voltage (MV/LV) transformers for overvoltage prevention has not been thoroughly investigated. This paper presents the application of active MV/LV transformers for increasing the PV hosting capacity of LV grids...... increase the PV hosting capacity of the grid, while eliminating the need for a complex and centralized controller. The voltages of specific locations or the grid state estimations provide adequate data for adjustments of the droop parameters. The simulations and field test results associated...

  6. Cloning and characterization of a novel hemocyanin variant LvHMCV4 from shrimp Litopenaeus vannamei.

    Science.gov (United States)

    Lu, Xin; Lu, Hui; Guo, Lingling; Zhang, Zehui; Zhao, Xianliang; Zhong, Mingqi; Li, Shengkang; Zhang, Yueling

    2015-10-01

    Recently, we found 3 variants of hemocyanin subunit with higher molecular weight in shrimp Litopenaeus vannamei (Named as LvHMCV1-3). In this study, a novel L. vannamei hemocyanin variant (Named as LvHMCV4) was further cloned and characterized. Bioinformatic analysis predicted that LvHMCV4 contains one open reading frame of 2137 bp and encodes a polypeptide of 678 amino acids. It shares 84-99% cDNA sequences identity to that of the classical form of L. vannamei hemocyanin (LvHMC, AJ250830.1) and LvHMCV1-3. LvHMCV4 possesses a conserved structure characteristic of the hemocyanin family and can be clustered into one branch along with other arthropod hemocyanins in a phylogenetic tree. Further, the full-length DNA of LvHMCV4 contains 2660 bp and two introns, which are located at the 80-538 bp and 2063-2227 bp regions, respectively. In addition, the mRNA transcript of LvHMCV4 was expressed highly in the hepatopancreas, lymphoid, brain and hemocytes, and weakly in the heart, intestine and gill, while no expression was found in the muscle, stomach and gut. Infection by Escherichia coli K12, Vibrio parahaemolyticus, Vibrio alginolyticus, Vibrio fluvialis, Streptococcus pyogenes or Staphylococcus aureus up-regulated significantly LvHMCV4 mRNA expression in the hepatopancreas. Furthermore, the recombinant protein of LvHMCV4 (rLvHMCV4) was prepared, which showed agglutination activities against six pathogenic bacteria at concentrations ranging from 15.6 to 125 μg/ml. When co-injected with V. parahaemolyticus in L.vannamei, rLvHMCV4 significantly increased the survival rate after 48 h injection. Together, these studies suggested that hemocyanin variant, LvHMCV4, might be involved in shrimp resistance to pathogenic infection.

  7. A Dynamic and Heuristic Phase Balancing Method for LV Feeders

    Directory of Open Access Journals (Sweden)

    Samad Taghipour Boroujeni

    2016-01-01

    Full Text Available Due to the single-phase loads and their stochastic behavior, the current in the distribution feeders is not balanced. In addition, the single-phase loads are located in different positions along the LV feeders. So the amount of the unbalanced load and its location affect the feeder losses. An unbalanced load causes the feeder losses and the voltage drop. Because of time-varying behavior of the single-phase loads, phase balancing is a dynamic and combinatorial problem. In this research, a heuristic and dynamic solution for the phase balancing of the LV feeders is proposed. In this method, it is supposed that the loads’ tie could be connected to all phases through a three-phase switch. The aim of the proposed method is to make the feeder conditions as balanced as possible. The amount and the location of single-phase loads are considered in the proposed phase balancing method. Since the proposed method needs no communication interface or no remote controller, it is inexpensive, simple, practical, and robust. Applying this method provides a distributed and dynamic phase balancing control. In addition, the feasibility of reducing the used switches is investigated. The ability of the proposed method in the phase balancing of the LV feeders is approved by carrying out some simulations.

  8. Avoided losses on LV networks as a result of microgeneration

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Paulo Moises [Escola Superior Tecnologia Viseu, Instituto Politecnico Viseu, Campus Politecnico Repeses, 3504-510 Viseu (Portugal); Matos, Manuel A. [INESC Porto, Faculdade de Engenharia da Universidade do Porto, Porto (Portugal)

    2009-04-15

    In the scope of the discussions about microgeneration (and microgrids), the avoided electrical losses are often pointed out as an important value to be credited to those entities. Therefore, methods to assess the impact of microgeneration on losses must be developed in order to support the definition of a suitable regulatory framework for the economic integration of microgeneration on distribution networks. This paper presents an analytical method to quantify the value of avoided losses that microgeneration may produce on LV networks. Intervals of expected avoided losses are used to account for the variation of avoided losses due to the number, size and location of microgenerators, as well as for the kind of load distribution on LV networks. (author)

  9. Effect of Impact Location on the Response of Shuttle Wing Leading Edge Panel 9

    Science.gov (United States)

    Lyle, Karen H.; Spellman, Regina L.; Hardy, Robin C.; Fasanella, Edwin L.; Jackson, Karen E.

    2005-01-01

    The objective of this paper is to compare the results of several simulations performed to determine the worst-case location for a foam impact on the Space Shuttle wing leading edge. The simulations were performed using the commercial non-linear transient dynamic finite element code, LS-DYNA. These simulations represent the first in a series of parametric studies performed to support the selection of the worst-case impact scenario. Panel 9 was selected for this study to enable comparisons with previous simulations performed during the Columbia Accident Investigation. The projectile for this study is a 5.5-in cube of typical external tank foam weighing 0.23 lb. Seven locations spanning the panel surface were impacted with the foam cube. For each of these cases, the foam was traveling at 1000 ft/s directly aft, along the orbiter X-axis. Results compared from the parametric studies included strains, contact forces, and material energies for various simulations. The results show that the worst case impact location was on the top surface, near the apex.

  10. Novel approach for automatic segmentation of LV endocardium via SPCNN

    Science.gov (United States)

    Ma, Yurun; Wang, Deyuan; Ma, Yide; Lei, Ruoming; Wang, Kemin

    2017-02-01

    Automatic segmentation of Left Ventricle (LV) is an essential task in the field of computer-aided analysis of cardiac function. In this paper, a simplified pulse coupled neural network (SPCNN) based approach is proposed to segment LV endocardium automatically. Different from the traditional image-driven methods, the SPCNN based approach is independent of the image gray distribution models, which makes it more stable. Firstly, the temporal and spatial characteristics of the cardiac magnetic resonance image are used to extract a region of interest and to locate LV cavity. Then, SPCNN model is iteratively applied with an increasing parameter to segment an optimal cavity. Finally, the endocardium is delineated via several post-processing operations. Quantitative evaluation is performed on the public database provided by MICCAI 2009. Over all studies, all slices, and two phases (end-diastole and end-systole), the average percentage of good contours is 91.02%, the average perpendicular distance is 2.24 mm and the overlapping dice metric is 0.86.These results indicate that the proposed approach possesses high precision and good competitiveness.

  11. Modularity bounds for clusters located by leading eigenvectors of the normalized modularity matrix

    CERN Document Server

    Fasino, Dario

    2016-01-01

    Nodal theorems for generalized modularity matrices ensure that the cluster located by the positive entries of the leading eigenvector of various modularity matrices induces a connected subgraph. In this paper we obtain lower bounds for the modularity of that set of nodes showing that, under certain conditions, the nodal domains induced by eigenvectors corresponding to highly positive eigenvalues of the normalized modularity matrix have indeed positive modularity, that is they can be recognized as modules inside the network. Moreover we establish Cheeger-type inequalities for the cut-modularity of the graph, providing a theoretical support to the common understanding that highly positive eigenvalues of modularity matrices are related with the possibility of subdividing a network into communities.

  12. Efficacy of an inactivated FeLV vaccine compared to a recombinant FeLV vaccine in minimum age cats following virulent FeLV challenge.

    Science.gov (United States)

    Stuke, Kristin; King, Vickie; Southwick, Kendra; Stoeva, Mira I; Thomas, Anne; Winkler, M Teresa C

    2014-05-07

    The aim of the study was to determine the efficacy of an inactivated feline leukemia virus (FeLV) vaccine (Versifel(®) FeLV, Zoetis.) compared to a recombinant FeLV vaccine (Purevax(®) FeLV, Merial Animal Health) in young cats, exposed under laboratory conditions to a highly virulent challenge model. The study was designed to be consistent with the general immunogenicity requirements of the European Pharmacopoeia 6.0 Monograph 01/2008:1321-Feline Leukaemia Vaccine (Inactivated) with the exception that commercial-strength vaccines were assessed. Fifty seronegative cats (8-9 weeks old) were vaccinated subcutaneously on two occasions, three weeks apart, with either placebo (treatment group T01), Versifel FeLV Vaccine (treatment group T02), or Purevax FeLV Vaccine (treatment group T03) according to the manufacturer's directions. Cats were challenged three weeks after the second vaccination with a virulent FeLV isolate (61E strain). Persistent FeLV antigenemia was determined from 3 to 15 weeks postchallenge. Bone marrow samples were tested for the presence of FeLV proviral DNA to determine FeLV latent infection. At week 15 after challenge with the virulent FeLV 61E strain, the Versifel FeLV Vaccine conferred 89.5% protection against FeLV persistent antigenemia and 94.7% protection against FeLV proviral DNA integration in bone marrow cells. In comparison, the Purevax FeLV Vaccine conferred 20% protection against FeLV persistent antigenemia and 35% protection against FeLV proviral DNA integration in bone marrow cells following challenge. The data from this study show that the Versifel FeLV Vaccine was efficacious in preventing both FeLV persistent p27 antigenemia and FeLV proviral DNA integration in bone marrow cells of cats challenged with this particular challenge model under laboratory conditions and provided better protection than Purevax FeLV in this experimental challenge model with highly virulent FeLV.

  13. [Transbronchoscopic end-tidal carbon dioxide detection for location of the leading bronchus in patients with pneumothorax].

    Science.gov (United States)

    Zeng, Yiming; Lin, Huihuang

    2015-04-01

    To evaluate the effect of end-tidal carbon dioxide (EtCO2) detection for location of the leading bronchus in patients with pneumothorax. Transbronchoscopic EtCO2 detection was performed in 4 patients with intractable pneumothorax in whom transbronchoscopic balloon detection failed to localize the leading bronchus. A specific bronchus was suspected to be the leading bronchus when its EtCO2 value was significantly lower than that of the main bronchus of the affected lung. After the pleural air leakage was successfully sealed by bronchial occlusion of the suspected bronchus, the EtCO2 was confirmed to indicate the leading bronchus. Transbronchoscopic EtCO2 detection successfully located the leading bronchus in all 4 patients. Transbronchoscopic EtCO2 detection is a new method of locating the leading bronchus in patients with intractable pneumothorax.

  14. Protection of LV system against lightning

    OpenAIRE

    Yordanova Nedyalkova, Greta

    2010-01-01

    Lightning is a natural hazard and one of the greatest local mysteries. Scientists have not fully understood the mechanism of lightning. It is one of the most beautiful displays in nature and one of the nature's most dangerous phenomenon known to man. Overvoltage due to lightning is a very important problem of LV systems. Some lightning flashes damage buildings and a few kill or injure people and animals, either directly or indirectly, by causing fire and explosions. The need for protect...

  15. Human health risk assessment of lead from mining activities at semi-arid locations in the context of total lead exposure.

    Science.gov (United States)

    Zheng, Jiajia; Huynh, Trang; Gasparon, Massimo; Ng, Jack; Noller, Barry

    2013-12-01

    Lead from historical mining and mineral processing activities may pose potential human health risks if materials with high concentrations of bioavailable lead minerals are released to the environment. Since the Joint Expert Committee on Food Additives of Food and Agriculture Organization/World Health Organization withdrew the Provisional Tolerable Weekly Intake of lead in 2011, an alternative method was required for lead exposure assessment. This study evaluated the potential lead hazard to young children (0-7 years) from a historical mining location at a semi-arid area using the U.S. EPA Integrated Exposure Uptake Biokinetic (IEUBK) Model, with selected site-specific input data. This study assessed lead exposure via the inhalation pathway for children living in a location affected by lead mining activities and with specific reference to semi-arid conditions and made comparison with the ingestion pathway by using the physiologically based extraction test for gastro-intestinal simulation. Sensitivity analysis for major IEUBK input parameters was conducted. Three groups of input parameters were classified according to the results of predicted blood concentrations. The modelled lead absorption attributed to the inhalation route was lower than 2 % (mean ± SE, 0.9 % ± 0.1 %) of all lead intake routes and was demonstrated as a less significant exposure pathway to children's blood, compared with ingestion. Whilst dermal exposure was negligible, diet and ingestion of soil and dust were the dominant parameters in terms of children's blood lead prediction. The exposure assessment identified the changing role of dietary intake when house lead loadings varied. Recommendations were also made to conduct comprehensive site-specific human health risk assessment in future studies of lead exposure under a semi-arid climate.

  16. Influence of location of the lead wires on calculation results of grounding transient characteristics of a grounding rod

    Directory of Open Access Journals (Sweden)

    Kuklin D. V.

    2016-12-01

    Full Text Available For calculations and measurements of transient characteristics of groundings, the current and potential lead wires are frequently used accordingly to inject the current into the grounding and find the grounding potential rise (GPR. The results of the calculations and measurements can be dependent on the location of the current and potential lead wires due to mutual influence between them and the grounding wire. It is important to determine to what extent the location of the wires influences the calculation results for the grounding with a simple configuration. Notably, in contrast to the measurements, for the calculations it is possible to locate wires vertically, also the potential lead wire can be replaced by the integral of the electric field. For the calculations the finite difference time domain method (FDTD has been used in the work. In order to estimate to what extent the calculated GPR can be influenced by location of the wires, calculations with different wires locations have been carried out. An analysis of the calculation results has been made. There are calculation methods in which the injection of the current and calculation of the GPR are performed without the current and potential lead wires. The method based on the telegrapher's equations is one of such methods. In order to determine what location of the lead wires gives the same calculation results as those of the method that uses the telegrapher's equations, a comparison of calculation results of two methods has been made. Based on the calculation results it can be concluded that the calculated transient characteristics depend to a different extent on such factors as mutual location of the lead wires and the grounding wire, replacing the potential lead wire by the integral of the electric field, electrical parameters of the soil. Location of one of the lead wires above the grounding wire significantly reduces the calculated GPR. Calculation results for a perpendicular location

  17. Association Between Myocardial Mechanics and Ischemic LV Remodeling.

    Science.gov (United States)

    D'Elia, Nicholas; D'hooge, Jan; Marwick, Thomas H

    2015-12-01

    The outcomes associated with heart failure after myocardial infarction are still poor. Both global and regional left ventricular (LV) remodeling are associated with the progression of the post-infarct patient to heart failure, but although global remodeling can be accurately measured, regional LV remodeling has been more difficult to investigate. Preliminary evidence suggests that post-MI assessment of LV mechanics using stress and strain may predict global (and possibly regional) LV remodeling. A method of predicting both global and regional LV remodeling might facilitate earlier, targeted, and more extensive clinical intervention in those most likely to benefit from novel interventions such as cell therapy.

  18. Alignment of leading-edge and peak-picking time of arrival methods to obtain accurate source locations

    Energy Technology Data Exchange (ETDEWEB)

    Roussel-Dupre, R.; Symbalisty, E.; Fox, C.; and Vanderlinde, O.

    2009-08-01

    The location of a radiating source can be determined by time-tagging the arrival of the radiated signal at a network of spatially distributed sensors. The accuracy of this approach depends strongly on the particular time-tagging algorithm employed at each of the sensors. If different techniques are used across the network, then the time tags must be referenced to a common fiducial for maximum location accuracy. In this report we derive the time corrections needed to temporally align leading-edge, time-tagging techniques with peak-picking algorithms. We focus on broadband radio frequency (RF) sources, an ionospheric propagation channel, and narrowband receivers, but the final results can be generalized to apply to any source, propagation environment, and sensor. Our analytic results are checked against numerical simulations for a number of representative cases and agree with the specific leading-edge algorithm studied independently by Kim and Eng (1995) and Pongratz (2005 and 2007).

  19. Lead

    Science.gov (United States)

    ... found? Who is at risk? What are the health effects of lead? Get educational material about lead Get certified as a Lead Abatement Worker, or other abatement discipline Lead in drinking water Lead air pollution Test your child Check and maintain your home ...

  20. 3D quantitative visualization of altered LV wall thickening dynamics caused by coronary microembolization

    Science.gov (United States)

    Eusemann, Christian D.; Mohlenkamp, Stefan; Ritman, Erik L.; Robb, Richard A.

    2001-05-01

    Regional heart wall dynamics has been shown to be a sensitive indicator of LV wall ischemia. Rates of local LV wall thickening during a cardiac cycle can be measured and illustrated using functional parametric mappings. This display conveys the spatial distribution of dynamic strain in the myocardium and thereby provides a rapid qualitative appreciation of the severity and extent of the ischemic region. 3D reconstructions were obtained in an anesthetized pig from 8 adjacent, shortaxis, slices of the left ventricle imaged with an Electron Beam Computer Tomograph at 11 time points through one complete cardiac cycle. The 3D reconstructions were obtained before and after injection of 100 micrometer microspheres into the Left Anterior Descending (LAD) coronary artery. This injection causes microembolization of LAD artery branches within the heart wall. The image processing involved radially dividing the tomographic images of the myocardium into small subdivisions with color encoding of the local magnitude of regional thickness or regional velocities of LV wall thickening throughout the cardiac cycle. We compared the effectiveness of animation of wall thickness encoded in color versus a static image of computed rate of wall thickness change in color. The location, extent and severity of regional wall akinesis or dyskinesis, as determined from these displays, can then be compared to the region of embolization as indicated by the distribution of altered LV wall perfusion.

  1. EV Charging Facilities and Their Application in LV Feeders with Photovoltaics

    DEFF Research Database (Denmark)

    Marra, Francesco; Yang, Guangya; Træholt, Chresten

    2013-01-01

    for the different locations in the feeder. With time-series simulations, we quantify the energy size required for a station ESS. A Belgian LV residential grid, modeled using real PV generation and load profiles, is used as case study. The method and simulation results show the effectiveness of using public EV...... charging facilities with the additional function of voltage regulation in feeders with PV....

  2. Cooling Performance Test of the SCT LV&HV Power Supply Rack

    CERN Document Server

    Böhm, J; Vacek, V

    2005-01-01

    The cooling performance test of the 52U rack, housing SCT LV&HV power supplies for 192 detector modules, being located in USA15 cavern, has been curried out. The rack was equipped with two air-water heat exchangers, air turbine, four vertical fan tray units under crates and horizontal fans in four Artesyn AC/DC power supply units. The resistive dummy loads for 192 power supply channels have been placed in four crates and housed in the adjacent rack.

  3. Value of dobutamine stress tissue Doppler in evaluation of LV ...

    African Journals Online (AJOL)

    Shaimaa Ahmed Mostafa

    2014-12-12

    Dec 12, 2014 ... Prosthetic valve disease. Complicated PCI. LVEF less .... annulus moved toward the cardiac apex due to longitudinal contraction of the LV. ..... to fibrotic tissue is too high and also, improved the integrity of cardiac myocyte cell ...

  4. Noninvasive LV pressure estimation using subharmonic emissions from microbubbles.

    Science.gov (United States)

    Dave, Jaydev K; Halldorsdottir, Valgerdur G; Eisenbrey, John R; Raichlen, Joel S; Liu, Ji-Bin; McDonald, Maureen E; Dickie, Kris; Wang, Shumin; Leung, Corina; Forsberg, Flemming

    2012-01-01

    To develop a new noninvasive approach to quantify left ventricular (LV) pressures using subharmonic emissions from microbubbles, an ultrasound scanner was used in pulse inversion grayscale mode; unprocessed radiofrequency data were obtained with pulsed wave Doppler from the aorta and/or LV during Sonazoid infusion. Subharmonic data (in dB) were extracted and processed. Calibration factor (mm Hg/dB) from the aortic pressure was used to estimate LV pressures. Errors ranged from 0.19 to 2.50 mm Hg when estimating pressures using the aortic calibration factor, and were higher (0.64 to 8.98 mm Hg) using a mean aortic calibration factor. Subharmonic emissions from ultrasound contrast agents have the potential to noninvasively monitor LV pressures.

  5. Lead

    Science.gov (United States)

    ... Chapter 6 Chapter 7 Chapter 8 Chapter 9 Appendix I Appendix II Tables Figures State Programs Alabama Alaska Arizona ... Tool Kit Resources Healthy Homes and Lead Poisoning Prevention Training Center (HHLPPTC) Training Tracks File Formats Help: ...

  6. What You See Is What You Get: Lead Location Within Deep Brain Structures Is Accurately Depicted by Stereotactic Magnetic Resonance Imaging.

    Science.gov (United States)

    Hyam, Jonathan A; Akram, Harith; Foltynie, Thomas; Limousin, Patricia; Hariz, Marwan; Zrinzo, Ludvic

    2015-09-01

    Magnetic resonance imaging (MRI)-verified deep brain stimulation relies on the correct interpretation of stereotactic imaging documenting lead location in relation to visible anatomic target. However, it has been suggested that local signal distortion from the lead itself renders its depiction on MRI unreliable. To compare lead location on stereotactic MRI with subsequent location of its brain track after removal. Patients underwent deep brain stimulation with the use of MRI-guided and MRI-verified Leksell frame approach. Infection or suboptimal efficacy required lead removal and subsequent reimplantation by using the same technique. Postimplantation stereotactic MR images were analyzed. Lateral (x) and anteroposterior (y) distances from midcommissural point to center of the lead hypointensity were recorded at the anterior commissure-posterior commissure plane (pallidal electrode) or z = -4 (subthalamic electrode). Stereotactic MRI before the second procedure, x and y distances from the center of the visible lead track hypointensity to midcommissural point were independently recorded. Vectorial distance from center of the lead hypointensity to the center of its track was calculated. Sixteen electrode tracks were studied in 10 patients. Mean differences between lead artifact location and lead track location were: x coordinate 0.4 mm ± 0.2; y coordinate 0.6 mm ± 0.3. Mean vectorial distance was 0.7 mm ± 0.2. Stereotactic distance between lead location and subsequent brain track location on MRI was small. The mean discrepancy was approximately half the deep brain stimulation lead width. This suggests that lead hypointensity seen on postimplantation MRI is indeed an accurate representation of its real location within deep brain structures.

  7. Location, location, location

    NARCIS (Netherlands)

    Anderson, S.P.; Goeree, J.K.; Ramer, R.

    1997-01-01

    We analyze the canonical location-then-price duopoly game with general log- concave consumer densities. A unique pure-strategy equilibrium to the two-stage game exists if the density is not "too asymmetric" and not "too concave." These criteria are satisfied by many commonly used densities. Equilibr

  8. Seismic monitoring during acid stimulation of wells LV-4 and LV-13 at the Las Tres Virgenes geothermal field, BCS, Mexico; Monitoreo sismico durante la estimulacion acida de los pozos LV-4 y LV-13 del campo geotermico de Las Tres Virgenes, BCS, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Venegas Salgado, Saul; Arredondo Fragoso, Jesus; Ramirez Silva, German; Flores Armenta, Magaly; Ramirez Montes, Miguel [Comision Federal de Electricidad, Gerencia de Proyectos Geotermoelectricos, Morelia, Michoacan (Mexico)]. E-mail: magaly.flores@cfe.gob.mx

    2006-07-15

    From September through December 2004 a seismic monitoring in the Las Tres Virgenes, BCS, geothermal field was carried out simultaneously with the acid stimulation of wells LV-4 and LV-13. The seismic network had four digital seismographs and recorded 174 local seismic events, 131 regional ones and many more volcanic signals at seismic station TV20 during the acid stimulation. Additionally, 37 seismic events were located, 22 of them inside the most important geothermal zone at depths between 0.4 and 4 km with typically low magnitudes (0.7 to 2.2 Md). Two relevant zones were determined: Zone A related to the El Volcan fault system and Zone B related to injection well LV-8. In Zone A the well-induction stage and the operation start of the wells LV-4 and LV-13 after acidification on October 30 and November 17, 2004, increased seismic activity to a maximum of 12 daily events in early December. When the two wells in Zone B were cooled before the acidification, the seismic events recorded there increased to a maximum of 6 daily events on October 2, and then decreased. Also in Zone B the seismic activity increased after well-induction and the start of well production once they were acidified, recording up to 11 daily events in late November. According to the seismic distribution, we may conclude that the most active fault systems are El Volcan and El Viejo. New proposals for well locations in the field are supported by these results. [Spanish] De septiembre a diciembre de 2004 se realizo un estudio de monitoreo sismico en el campo geotermico de Las Tres Virgenes, BCS, simultaneamente con las estimulaciones acidas de los pozos LV-4 y LV-13. Se utilizo una red sismica conformada por cuatro sismografos digitales, logrando registrar en la estacion sismica TV20 un total de 174 sismos locales, 131 sismos regionales y muchas mas senales de tipo volcanico, durante el periodo del monitoreo de la estimulacion acida. Ademas, se localizaron un total de 37 sismos, de los cuales 22 se

  9. Formation and characterization of FeLV iscoms.

    NARCIS (Netherlands)

    L. Akerblom; K. Strö mstedt; S. Hö glund; A.D.M.E. Osterhaus (Albert); B. Morein (Bror)

    1989-01-01

    textabstractImmunostimulating complexes (ISCOMs) have been prepared from feline leukaemia virus (FeLV) envelope proteins. The ISCOMs were characterized biochemically in SDS-polyacrylamide gel electrophoresis showing the presence of proteins of estimated molecular weights of 15,000, 27,000 and 70,000

  10. Effective RNA-silencing strategy of Lv-MSTN/GDF11 gene and its effects on the growth in shrimp, Litopenaeus vannamei.

    Science.gov (United States)

    Lee, Ji-Hyun; Momani, Jalal; Kim, Young Mog; Kang, Chang-Keun; Choi, Jung-Hwa; Baek, Hae-Ja; Kim, Hyun-Woo

    2015-01-01

    Myostatin (MSTN), also known as GDF8, is a member of the transforming growth factor-β (TGF-β) superfamily and plays an important role in muscle growth, development, and differentiation. Recently, Lv-MSTN/GDF11, the primitive isoform of MSTN and GDF11, was identified from the shrimp Litopenaeus vannamei. The major production site for Lv-MSTN/GDF11 is in the heart, not the tail muscle, which differs from MSTNs in mammals. Among the three injected RNAs, long dsRNA was the most effective for Lv-MSTN/GDF11 knockdown and transcripts of Lv-MSTN/GDF11 decreased in both the heart (88.85%) and skeletal muscles (43.36%) 72h after injection of 10pmol of long dsRNA. We also found that higher doses of dsRNA did not lead to greater decreases in Lv-MSTN/GDF11 transcripts for amounts between 1pmol and 100pmol. Injection of Lv-MSTN/GDF11 dsRNA did not affect the upregulation of the skeletal actin gene (Lv-ACTINSK) in the tail muscle, but the expression of cytoplasmic and cardiac actins were upregulated in both the heart and tail muscle. Over the course of 8weeks of dsRNA injection, considerably higher mortality (~71%) was seen in the dsRNA-injected group compared to the control group (40%). Surviving shrimp in the dsRNA injected group had a lower growth rate due to the adverse effects of Lv-MSTN/GDF11 knockdown. Lv-MSTN/GDF11 appears to be involved in muscular or neuronal development, but not in doubling muscle fibers, as is the case with mammalian MSTN. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. Initial clinical experience with implantation of left ventricular lead guided by Overlay Ref for the treatment of congestive heart failure.

    Science.gov (United States)

    Zhang, Bu-Chun; Tang, Kai; Xu, Ya-Wei

    2011-01-01

    Cardiac resynchronization therapy (CRT) improves clinical outcome in selected patients with advanced congestive heart failure. The Overlay Ref technique may facilitate the procedure for implanting left ventricular (LV) pacing leads to deliver CRT. To assess the feasibility of deploying a LV pacing lead into a coronary sinus side branch guided by Overlay Ref. Data from 88 consecutive patients who met the CRT implantation criteria in our hospital between 28 November 2007 and 30 December 2009 were randomly assigned to two groups. Forty-four patients underwent CRT device implantation using Overlay Ref to guide target vein selection and advance a specifically designed pacing lead into the target vein (Overlay Ref group); 44 patients were conventionally implanted (control group). LV lead implantation was successful in all patients. Mean CRT total procedure times (skin-to-skin) were: Overlay Ref group, 80.7 ± 18.0 min; control group, 98.5 ± 32.2 min; p = 0.029. Mean placement of LV pacing lead into target vein times were: Overlay Ref group, 16.2 ± 7.7 min; control group, 36.4 ± 23.4 min; p=0.004. Mean total fluoroscopy times were: Overlay Ref group, 13.6 ± 4.3 min; control group, 23.8 ± 15.7 min; p=0.007. Mean LV lead fluoroscopy times were: Overlay Ref group, 5.7 ± 2.9 min; control group, 14.4 ± 4.6 min; p=0.003. No major complications occurred. Overlay Ref facilitates location of and entry into the coronary sinus, and shortens the duration of LV pacing lead implantation into the target vein. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  12. 77 FR 21620 - Notice of the Buy America Waiver Request for Vossloh 101-LV Concrete Ties

    Science.gov (United States)

    2012-04-10

    ... Federal Railroad Administration Notice of the Buy America Waiver Request for Vossloh 101-LV Concrete Ties... requirements for the purchase of Vossloh 101-LV concrete ties, which contain certain components not... consist of the installation of Vossloh 101-LV concrete ties. FRA has received this request from the four...

  13. Voltage rise mitigation for solar PV integration at LV grids

    DEFF Research Database (Denmark)

    Yang, Guangya; Marra, Francesco; Juamperez Goñi, Miguel Angel

    2015-01-01

    Solar energy from photovoltaic (PV) is among the fastest developing renewable energy systems worldwide. Driven by governmental subsidies and technological development, Europe has seen a fast expansion of solar PV in the last few years. Among the installed PV plants, most of them are situated...... at the distribution systems and bring various operational challenges such as power quality and power flow management. The paper discusses the modelling requirements for PV system integration studies, as well as the possible techniques for voltage rise mitigation at low voltage (LV) grids for increasing PV penetration...

  14. Solution to avoid unwanted trips for PV systems connected to LV network facing voltage sags

    Energy Technology Data Exchange (ETDEWEB)

    Le Thi Minh, Chau; Tran-Quoc, Tuan; Kieny, Christophe [IDEA, Saint-Martin-d' Heres (France); Bacha, Seddik [Grenoble Electric Engineering Laboratory, Saint-Martin-d' Heres (France); Cabanac, Philippe; Grenard, Sebastien [Electricite de France, Clamart (France). Direction des Etudes et Recherches; Goulielmakis, David [Schneider Electric, Grenoble (France). Projects and Engineering Center

    2011-07-01

    Most of photovoltaic (PV) systems connected to low voltage (LV) distribution networks have a single-phase connection. The analysis of the behavior of these single-phase connection. The analysis of the behavior of these single-phase PV inverters facing voltage sags caused by short circuits is of major concern. These behaviors depend on fault types, fault location, types of grid architecture, grid protection systems (with or without auto-recloser system) and PV protection types. Therefore, the first investigation of this work is to study comprehensively the behaviors of PV systems connected to real LV networks facing voltage sags in different scenarios by taking into account the real network protection. Furthermore, future power systems with a large share of PV systems connected could be severely affected if several of the PV systems are tripping at the same instant. From these results of simulation, unwanted trip cases, due to the disconnection protection of PV systems are identified. Finally, a simple efficient solution by using the voltage-time characteristic for PV system is proposed. The validation by simulations shows the efficiency of the proposed solution. (orig.)

  15. Optimal left ventricular lead position assessed with phase analysis on gated myocardial perfusion SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Boogers, Mark J. [Leiden University Medical Center, Department of Cardiology, Leiden (Netherlands); The Interuniversity Cardiology Institute of the Netherlands, Utrecht (Netherlands); Chen, Ji; Garcia, Ernest V. [Emory University School of Medicine, Department of Radiology, Atlanta, GA (United States); Bommel, Rutger J. van; Borleffs, C.J.W.; Schalij, Martin J.; Wall, Ernst E. van der; Bax, Jeroen J. [Leiden University Medical Center, Department of Cardiology, Leiden (Netherlands); Dibbets-Schneider, Petra; Hiel, Bernies van der; Younis, Imad Al [Leiden University Medical Center, Department of Nuclear Medicine, Leiden (Netherlands)

    2011-02-15

    The aim of the current study was to evaluate the relationship between the site of latest mechanical activation as assessed with gated myocardial perfusion SPECT (GMPS), left ventricular (LV) lead position and response to cardiac resynchronization therapy (CRT). The patient population consisted of consecutive patients with advanced heart failure in whom CRT was currently indicated. Before implantation, 2-D echocardiography and GMPS were performed. The echocardiography was performed to assess LV end-systolic volume (LVESV), LV end-diastolic volume (LVEDV) and LV ejection fraction (LVEF). The site of latest mechanical activation was assessed by phase analysis of GMPS studies and related to LV lead position on fluoroscopy. Echocardiography was repeated after 6 months of CRT. CRT response was defined as a decrease of {>=}15% in LVESV. Enrolled in the study were 90 patients (72% men, 67{+-}10 years) with advanced heart failure. In 52 patients (58%), the LV lead was positioned at the site of latest mechanical activation (concordant), and in 38 patients (42%) the LV lead was positioned outside the site of latest mechanical activation (discordant). CRT response was significantly more often documented in patients with a concordant LV lead position than in patients with a discordant LV lead position (79% vs. 26%, p<0.01). After 6 months, patients with a concordant LV lead position showed significant improvement in LVEF, LVESV and LVEDV (p<0.05), whereas patients with a discordant LV lead position showed no significant improvement in these variables. Patients with a concordant LV lead position showed significant improvement in LV volumes and LV systolic function, whereas patients with a discordant LV lead position showed no significant improvements. (orig.)

  16. Serological survey of Toxoplasma gondii, Dirofilaria immitis, Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) infections in pet cats in Bangkok and vicinities, Thailand.

    Science.gov (United States)

    Sukhumavasi, Woraporn; Bellosa, Mary L; Lucio-Forster, Araceli; Liotta, Janice L; Lee, Alice C Y; Pornmingmas, Pitcha; Chungpivat, Sudchit; Mohammed, Hussni O; Lorentzen, Leif; Dubey, J P; Bowman, Dwight D

    2012-08-13

    The seroprevalence of Toxoplasma gondii, Dirofilaria immitis (heartworm), feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) infections was examined using serum or plasma samples from 746 pet cats collected between May and July 2009 from clinics and hospitals located in and around Bangkok, Thailand. The samples were tested for heartworm, FIV, and FeLV using a commercial ELISA. Of the 746 samples, 4.6% (34/746) were positive for heartworm antigen, 24.5% (183/746) had circulating FeLV antigen, and 20.1% (150/746) had antibodies against FIV. In addition, the first 348 submitted samples were tested for T. gondii antibodies using a modified agglutination test (MAT, cut off 1:25); 10.1% (35/348) were seropositive. Of the 348 cats sampled for all four pathogens, 11, 10, and 1 were positive for T. gondii antibodies and FIV antibodies, FeLV antigen, or D. immitis antigen, respectively. Of the 35 T. gondii-seropositive cats, 42.9% (15/35) were co-infected with at least one of the other three pathogens. The presence of antibodies to FIV was significantly associated with both age and gender, while FeLV antigen presence was only associated with age. In the case of FIV, males were twice as likely to be infected as females, and cats over 10 years of age were 13.5 times more likely to be infected than cats less than 1 year of age. FeLV antigen was more common in younger cats, with cats over 10 years of age being 10 times less likely to be FeLV positive than cats under 1 year of age. This is the first survey for these four pathogens affecting feline health in Thailand.

  17. Serological survey of Toxoplasma gondii, Dirofilaria immitis, Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) infections in pet cats in Bangkok and vicinities, Thailand

    Science.gov (United States)

    The seroprevalence of Toxoplasma gondii, Dirofilaria immitis (heartworm), feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) infections was examined using serum or plasma samples from 746 pet cats collected between May and July 2009 from clinics and hospitals located in and around ...

  18. LvDJ-1 plays an important role in resistance against Vibrio alginolyticus in Litopenaeus vannamei.

    Science.gov (United States)

    Huang, Mingzhu; Liu, Yuan; Xie, Chenying; Wang, Wei-Na

    2015-05-01

    DJ-1 was first identified as an oncogene that transformed mouse NIH3T3 cells in cooperation with activated Ras. It has since exhibited a variety of functions in a range of organisms. In this study, the DJ-1 gene in Litopenaeus vannamei (LvDJ-1) was identified and characterized. A recombinant protein LvDJ-1 was produced in Pichia pastoris. LvDJ-1 expression in vivo was knocked down by dsRNA-mediated RNA interference (RNAi), which led to significantly decreased levels of LvDJ-1 mRNA and protein. When the L. vannamei were challenged with RNAi and Vibrio alginolyticus, the transcription and expression of copper zinc superoxide dismutase (LvCZSOD) in the hepatopancreas were dramatically lower in shrimp with knocked down LvDJ-1 than in controls. Transcription and expression of P53 (LvP53) were significantly higher in shrimp lacking LvDJ-1 than in controls. Hepatopancreas samples were analyzed using real time polymerase chain reaction and Western blot. Moreover, blood samples from the shrimp, assessed with flow cytometry, showed significant increases in respiratory burst and apoptosis in those lacking LvDJ-1 compared to the controls. Cumulative mortality in the shrimp lacking LvDJ-1 was significantly different from that in the control group after challenge with V. alginolyticus. Altogether, the results prove that LvDJ-1 regulates apoptosis and antioxidant activity, and that these functions play an important role in L. vannamei resistance against V. alginolyticus.

  19. Noise Characteristics of Centrifugal Blower with Low Solidity Cascade Diffuser (Noise Reduction by means of Small Groove Located at LSD Blade Leading Tip)

    Institute of Scientific and Technical Information of China (English)

    Tengen MURAKAMI; Masahiro ISHIDA; Daisaku SAKAGUCHI; Yu KOBA

    2009-01-01

    This paper deals with the effect of the blade tip-groove of the low solidity cascade diffuser (LSD) on the blower characteristic and the noise generated by the LSD. The small grooves were set up at the root and/or tip near the leading edge of the LSD blade. In order to clarify the mechanism of noise increase due to LSD and also to reduce the noise, the relationships between the noise increase based on the LSD, the LSD performance and the secondary flow formed additionally by the tip-groove were investigated experimentally as well as numerically, especially analyzing flow behaviors in the LSD in view points of flow separation on the suction surface of the LSD blade and the secondary flow on the side walls. By reducing the stagnation region smaller near the root and/or tip of the LSD blade leading edge, the secondary flow behavior changes remarkably around the LSD blade, as a result, the noise level and the blower characteristics vary. It can be concluded that, by means of a small tip-groove located only at the shroud side near the LSD blade leading edge, the noise generated by the LSD can be reduced without deteriorations of the LSD performance and the blower characteristics as well.

  20. Impact of Distributed Generation Grid Code Requirements on Islanding Detection in LV Networks

    Directory of Open Access Journals (Sweden)

    Fabio Bignucolo

    2017-01-01

    Full Text Available The recent growing diffusion of dispersed generation in low voltage (LV distribution networks is entailing new rules to make local generators participate in network stability. Consequently, national and international grid codes, which define the connection rules for stability and safety of electrical power systems, have been updated requiring distributed generators and electrical storage systems to supply stabilizing contributions. In this scenario, specific attention to the uncontrolled islanding issue has to be addressed since currently required anti-islanding protection systems, based on relays locally measuring voltage and frequency, could no longer be suitable. In this paper, the effects on the interface protection performance of different LV generators’ stabilizing functions are analysed. The study takes into account existing requirements, such as the generators’ active power regulation (according to the measured frequency and reactive power regulation (depending on the local measured voltage. In addition, the paper focuses on other stabilizing features under discussion, derived from the medium voltage (MV distribution network grid codes or proposed in the literature, such as fast voltage support (FVS and inertia emulation. Stabilizing functions have been reproduced in the DIgSILENT PowerFactory 2016 software environment, making use of its native programming language. Later, they are tested both alone and together, aiming to obtain a comprehensive analysis on their impact on the anti-islanding protection effectiveness. Through dynamic simulations in several network scenarios the paper demonstrates the detrimental impact that such stabilizing regulations may have on loss-of-main protection effectiveness, leading to an increased risk of unintentional islanding.

  1. A Scenario-Based Approach for Energy Storage Capacity Determination in LV Grids with High PV Penetration

    DEFF Research Database (Denmark)

    Hashemi Toghroljerdi, Seyedmostafa; Østergaard, Jacob; Yang, Guangya

    2014-01-01

    In this paper a new method is proposed to determine the minimum energy storage required to be installed at different locations of a low voltage (LV) grid in order to prevent the overvoltage due to high residential photovoltaic (PV) penetration. The method is based on the voltage sensitivity...... with different occurrence probabilities without involving the time-series studies problems. The proposed method is capable of modeling output power of PV panels with different orientations as well as different electric vehicle (EV) charging patterns....

  2. Application of SPCALC for chemical and thermodynamic speciation of fluids -example for wells LV-4A, LV-11 and LV-13, Las Tres Virgenes geothermal field, BCS; Aplicacion del SPCALC en la especiacion quimica y termodinamica de fluidos: ejemplo del caso de los pozos LV-4A, LV-11 y LV-13, del campo geotermico de Las Tres Virgenes, BCS

    Energy Technology Data Exchange (ETDEWEB)

    Viggiano Guerra, J.C.; Sandoval Medina, F.; Flores Armenta, M.C. [Comision Federal de Electricidad, Gerencia de Proyectos Geotermoelectricos, Morelia, Michoacan (Mexico)]. E-mail: fernando.sandoval@cfe.gob.mx, E-mail: magaly.flores@cfe.gob.mx; Perez, R.J. [Universidad de Calgary (Canada); Gonzalez Partida, E. [Universidad Nacional Autonoma de Mexico, Centro de Geociencias, Mexico, D.F. (Mexico)

    2009-01-15

    SPCALC is an excellent software application providing chemical and multi-phase speciation for geothermal fluids. Recently it was acquired by the Comision Federal de Electricidad (CFE) through a contract with the National Autonomous University of Mexico (UNAM) and the University of Calgary, Canada. Software methodology consists of calculating thermodynamic variables, such as activity (a) and fugacity (f) of chemical species, as well as the saturation indices (log Q/K) of mineral phases of the reservoir. In other words, it models the thermodynamic conditions of the reservoir (pH among other) and simulates the fluid-corrosion rate. This allows the software to foresee scaling and corrosion. In this paper, pervasive fluids in Cretaceous granitic rocks penetrated by wells LV-4A, LV-11 and LV-13 in Las Tres Virgenes geothermal field, BCS, are modeled, starting with chemical analyses. The more important ratios among activities [those which influence the fluid-rock interaction (i.e. {sup a}K{sup +}/{sup a}H{sup +}, {sup a}Ca{sup ++}/{sup a}H{sup +}, {sup a}Na{sup +}/{sup a}H{sup +}, {sup a}Mg{sup ++}/{sup a}H{sup +}) and whose results are the minerals visible under a microscope] are graphed in balance diagrams compatible with the pressure (P) and temperature (T) conditions in the reservoir. Epidote (zoisite) is the mineral found in congruent equilibrium with the system. The main mineral association at those conditions (200-250 degrees Celsius and {approx}18 bar), as observed in the well cuttings, is calcite+illite-quartz{+-}epidote, which is explained by the hydrolithic reactions that form replacement calcite in the presence of CO{sub 2}, thus restricting the formation of epidote and eventually eliminating it. The process enhances the CO{sub 2} molarity in the residual fluid, even up to {sup m}CO{sub 2} 1, which means the CO{sub 2} can be diluted back into fluid and intervene again in the process of calcite formation (2HCO{sub 3}{sup -} + Ca{sup ++} = calcite + H{sub 2}O

  3. Impact of right-ventricular apical pacing on the optimal left-ventricular lead positions measured by phase analysis of SPECT myocardial perfusion imaging

    Energy Technology Data Exchange (ETDEWEB)

    Hung, Guang-Uei [Chang Bing Show Chwan Memorial Hospital, Changhua (China); China Medical University, Department of Biomedical Imaging and Radiological Science, Taichung (China); Huang, Jin-Long [Taichung Veterans General Hospital, Cardiovascular Center, Taichung (China); School of Medicine, National Yang-Ming University, Institute of Clinical Medicine, and Cardiovascular Research Institute, Department of Medicine, Taipei (China); Chung-Shan Medical University, Department of Medicine, School of Medicine, Taichung (China); Lin, Wan-Yu; Tsai, Shih-Chung [Taichung Veterans General Hospital, Department of Nuclear Medicine, Taichung (China); Wang, Kuo-Yang [Taichung Veterans General Hospital, Cardiovascular Center, Taichung (China); Chung-Shan Medical University, Department of Medicine, School of Medicine, Taichung (China); Chen, Shih-Ann [School of Medicine, National Yang-Ming University, Institute of Clinical Medicine, and Cardiovascular Research Institute, Department of Medicine, Taipei (China); Taipei Veterans General Hospital, Division of Cardiology, Department of Medicine, Taipei (China); Lloyd, Michael S.; Chen, Ji [Emory University, Department of Radiology and Imaging Sciences, Atlanta, GA (United States)

    2014-06-15

    The use of SPECT phase analysis to optimize left-ventricular (LV) lead positions for cardiac resynchronization therapy (CRT) was performed at baseline, but CRT works as simultaneous right ventricular (RV) and LV pacing. The aim of this study was to assess the impact of RV apical (RVA) pacing on optimal LV lead positions measured by SPECT phase analysis. This study prospectively enrolled 46 patients. Two SPECT myocardial perfusion scans were acquired under sinus rhythm with complete left bundle branch block and RVA pacing, respectively, following a single injection of {sup 99m}Tc-sestamibi. LV dyssynchrony parameters and optimal LV lead positions were measured by the phase analysis technique and then compared between the two scans. The LV dyssynchrony parameters were significantly larger with RVA pacing than with sinus rhythm (p ∝0.01). In 39 of the 46 patients, the optimal LV lead positions were the same between RVA pacing and sinus rhythm (kappa = 0.861). In 6 of the remaining 7 patients, the optimal LV lead positions were along the same radial direction, but RVA pacing shifted the optimal LV lead positions toward the base. The optimal LV lead positions measured by SPECT phase analysis were consistent, no matter whether the SPECT images were acquired under sinus rhythm or RVA pacing. In some patients, RVA pacing shifted the optimal LV lead positions toward the base. This study supports the use of baseline SPECT myocardial perfusion imaging to optimize LV lead positions to increase CRT efficacy. (orig.)

  4. Separate base usages of genes located on the leading and lagging strands in Chlamydia muridarum revealed by the Z curve method

    Directory of Open Access Journals (Sweden)

    Yu Xiu-Juan

    2007-10-01

    Full Text Available Abstract Background The nucleotide compositional asymmetry between the leading and lagging strands in bacterial genomes has been the subject of intensive study in the past few years. It is interesting to mention that almost all bacterial genomes exhibit the same kind of base asymmetry. This work aims to investigate the strand biases in Chlamydia muridarum genome and show the potential of the Z curve method for quantitatively differentiating genes on the leading and lagging strands. Results The occurrence frequencies of bases of protein-coding genes in C. muridarum genome were analyzed by the Z curve method. It was found that genes located on the two strands of replication have distinct base usages in C. muridarum genome. According to their positions in the 9-D space spanned by the variables u1 – u9 of the Z curve method, K-means clustering algorithm can assign about 94% of genes to the correct strands, which is a few percent higher than those correctly classified by K-means based on the RSCU. The base usage and codon usage analyses show that genes on the leading strand have more G than C and more T than A, particularly at the third codon position. For genes on the lagging strand the biases is reverse. The y component of the Z curves for the complete chromosome sequences show that the excess of G over C and T over A are more remarkable in C. muridarum genome than in other bacterial genomes without separating base and/or codon usages. Furthermore, for the genomes of Borrelia burgdorferi, Treponema pallidum, Chlamydia muridarum and Chlamydia trachomatis, in which distinct base and/or codon usages have been observed, closer phylogenetic distance is found compared with other bacterial genomes. Conclusion The nature of the strand biases of base composition in C. muridarum is similar to that in most other bacterial genomes. However, the base composition asymmetry between the leading and lagging strands in C. muridarum is more significant than that in

  5. Inferring microbial interaction networks from metagenomic data using SgLV-EKF algorithm.

    Science.gov (United States)

    Alshawaqfeh, Mustafa; Serpedin, Erchin; Younes, Ahmad Bani

    2017-03-27

    Inferring the microbial interaction networks (MINs) and modeling their dynamics are critical in understanding the mechanisms of the bacterial ecosystem and designing antibiotic and/or probiotic therapies. Recently, several approaches were proposed to infer MINs using the generalized Lotka-Volterra (gLV) model. Main drawbacks of these models include the fact that these models only consider the measurement noise without taking into consideration the uncertainties in the underlying dynamics. Furthermore, inferring the MIN is characterized by the limited number of observations and nonlinearity in the regulatory mechanisms. Therefore, novel estimation techniques are needed to address these challenges. This work proposes SgLV-EKF: a stochastic gLV model that adopts the extended Kalman filter (EKF) algorithm to model the MIN dynamics. In particular, SgLV-EKF employs a stochastic modeling of the MIN by adding a noise term to the dynamical model to compensate for modeling uncertainties. This stochastic modeling is more realistic than the conventional gLV model which assumes that the MIN dynamics are perfectly governed by the gLV equations. After specifying the stochastic model structure, we propose the EKF to estimate the MIN. SgLV-EKF was compared with two similarity-based algorithms, one algorithm from the integral-based family and two regression-based algorithms, in terms of the achieved performance on two synthetic data-sets and two real data-sets. The first data-set models the randomness in measurement data, whereas, the second data-set incorporates uncertainties in the underlying dynamics. The real data-sets are provided by a recent study pertaining to an antibiotic-mediated Clostridium difficile infection. The experimental results demonstrate that SgLV-EKF outperforms the alternative methods in terms of robustness to measurement noise, modeling errors, and tracking the dynamics of the MIN. Performance analysis demonstrates that the proposed SgLV-EKF algorithm

  6. Computational nano OPC DFM for LV Fin-type SRAM

    Science.gov (United States)

    Kadota, Kazuya

    2016-05-01

    Design For Manufacturing (DFM) where the state-of-the-art nano-devices of the sub-20nm node to a subject, for each of the technology has been intricately sophisticated, comprehensive optimization to predict the performance of the device came become very important. [1] To get effective solutions on these subjects, one of the lithographic key is a nano Optical Proximity Correction (OPC) control with SMO technology, and another is TCAD approach using the most advanced computer simulations. And, it is very important to obtain DFM solutions by integrating both. On the other hand, to meet the needs of low-voltage drive and the characteristic variability reduction, in order to obtain a state-of-the-art device performance, the Fin-type transistors are introduced globally as the mainstream because of wider process control margin. This paper, from the point of view of the sub-20nm node DFM, the simulation are conducted on ArF-imm. technology with SMO in SPT, DPT and QPT on TachyonTM [2], and the guideline of design rules are obtained. Furthermore, the simulated transistor pattern shape are directly migrated into TCAD process flow on HyENEXSSTM [3]. Then calculated I-V characteristics on 6 transistors under the various parameters on TCAD, and finally summarized Static Noise Margin (SNM) of SRAMs. Here, various parameters that determine the performance of SRAMs (Fin width, height, angle, dopant concentrations, electric field strength, work function, drive voltage, and operation speed) are intentionally varied and calculated on the TCAD. This computational method is highly sophisticated DFM technology to predict for the leading-edge nano-devices toward for the sub-20nm nodes era [4] [5] [6] [7] .

  7. 三洋推出Easy Radio IC系列LV24000PL

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    三洋(Sanyo)公司日前推出Easy Radio IC系列LV24000PL。LV24000PL是一款不需要使用外部元器件的便携式Device用FM调谐器芯片,尺寸仅约5mm×5mm×0.8mm,尺寸缩减为原来的六分之一,适用于手机、PDA等便携式产品。

  8. La piattaforma POS/LV di Applanix nelle applicazioni di laser scanner cinematico

    Directory of Open Access Journals (Sweden)

    Domenico Santarsiero

    2008-03-01

    Full Text Available The Applanix POS/LV platform in cinematic laser scanner applicationsOn the 11th of march the GEOmedia editorial unit had the pleasure of hosting a technical meeting dedicated to the Applanix LANDMark new Position and Orientation System for Land Vehicles (POS/LVfield test. The meeting, which is part of an italian tour organized by Louis Nastro (Applanix Director of Land Products and Terenzio Mariani (Sales manager for Italy, helped to test the functionalities of a complete POS/LV system equipped with a laser and an imaging acquisition software installed on board of a SUV.

  9. Characterization and DNA sequence of the mobilization region of pLV22a from Bacteroides fragilis.

    OpenAIRE

    Novicki, T. J.; Hecht, D. W.

    1995-01-01

    A 4.2-kb plasmid (pLV22a) native to Bacteroides fragilis LV22 became fused to a transfer-deficient Bacteroides spp.-Escherichia coli shuttle vector by an inverse transposition event, resulting in a transferrable phenotype. The transfer phenotype was attributable to pLV22a, which was also capable of mobilization within E. coli when coresident with the IncP beta R751 plasmid. Transposon mutagenesis with Tn1000 localized the mobilization region to a 1.5-kb DNA segment in pLV22a. The mobilization...

  10. Extinction in the Galaxy from surface brightnesses of ESO-LV galaxies : Testing "standard" extinction maps

    NARCIS (Netherlands)

    Choloniewski, J.; Valentijn, E. A.

    2003-01-01

    A new method for the determination of the extinction in the Galaxy is proposed. The method uses surface brightnesses of external galaxies in the B and R-bands. The observational data have been taken from the ESO-LV galaxy catalog. As a first application of our model we derive the ratio of R-band to

  11. Revisión diagramas de equilibrio Txy (LV y LLV)

    OpenAIRE

    Reyes Labarta, Juan Antonio

    2007-01-01

    Este tema se encarca en el contexto del estudio del equilibrio entre fases líquido-vapor. Se muestra de forma cualitativa diferentes ejemplos de diagramas de equilibrio LV, temperatura-composición (a presión constante), así como bibliografía relacionada. Universidad de Alicante. Dpto. Ingeniería Química

  12. Voltage unbalance mitigation in LV networks using three-phase PV systems

    DEFF Research Database (Denmark)

    Garcia Bajo, Cristina; Hashemi Toghroljerdi, Seyedmostafa; Bækhøj Kjær, Søren;

    2015-01-01

    In this paper a new method is proposed to mitigate voltage unbalance caused by single-phase solar inverters in low voltage (LV) networks. The method is based on uneven reactive power absorption and injection by three-phase solar inverters. Independent control of each phase is performed to achieve...

  13. Minimizing ventricular pacing by a novel atrioventricular (AV) delay hysteresis algorithm in patients with intact or compromised intrinsic AV conduction and different atrial and ventricular lead locations.

    Science.gov (United States)

    Pakarinen, Sami; Toivonen, Lauri

    2013-09-01

    To investigate if an advanced AV search hysteresis (AVSH) algorithm, Ventricular Intrinsic Preference (VIP(™)), reduces the incidence of ventricular pacing (VP) in sinus node dysfunction (SND) with both intact and compromised AV conduction and with intermittent AV block regardless of the lead positions in the right atria and the ventricle. Patients were classified as having intact AV (AVi) conduction if the PR interval was ≤ 210 ms on ECG and 1:1 AV conduction during atrial pacing up to 120 bpm with PR interval ≤ 350 ms. Otherwise the AV conduction was classified as compromised (AVc). Both AVi and AVc patients were randomized to VIP ON or OFF. VIP performed an intrinsic AV conduction search every 30 s for three consecutive atrial cycles with the extension of the sensed and paced AV (SAV/PAV) delays from basic values of 150/200 ms to 300/350 ms. Extended AV intervals were allowed for three cycles when VP occurred before returning to basic AV delays. The primary end-point was %VP at 12 months. Among 389 patients, 30.1% had intact and 69.9% had compromised AV conduction. The mean %VP at 12 months was 9.6% by VIP compared to 51.8% with standard AV settings in patients with AVi (P < 0.0001) and 28.0% versus 78.9% (P < 0.0001) with AVc. With VIP, excessive %VP among most used lead positions was not seen. Conversely, when VIP was off %VP was low only in patients who had leads in the RA septal-RV septal position (23.0%). VIP feature reduces VP both in patients with SND and with intermittent heart block regardless of the lead positions in the right atria and the ventricle.

  14. Locating sweet spots for screening hits and evaluating pan-assay interference filters from the performance analysis of two lead-like libraries.

    Science.gov (United States)

    Mok, N Yi; Maxe, Sara; Brenk, Ruth

    2013-03-25

    The efficiency of automated compound screening is heavily influenced by the design and the quality of the screening libraries used. We recently reported on the assembly of one diverse and one target-focused lead-like screening library. Using data from 15 enzyme-based screenings conducted using these libraries, their performance was investigated. Both libraries delivered screening hits across a range of targets, with the hits distributed across the entire chemical space represented by both libraries. On closer inspection, however, hit distribution was uneven across the chemical space, with enrichments observed in octants characterized by compounds at the higher end of the molecular weight and lipophilicity spectrum for lead-like compounds, while polar and sp(3)-carbon atom rich compounds were underrepresented among the screening hits. Based on these observations, we propose that screening libraries should not be evenly distributed in lead-like chemical space but be enriched in polar, aliphatic compounds. In conjunction with variable concentration screening, this could lead to more balanced hit rates across the chemical space and screening hits of higher ligand efficiency will be captured. Apart from chemical diversity, both screening libraries were shown to be clean from any pan-assay interference (PAINS) behavior. Even though some compounds were flagged to contain PAINS structural motifs, some of these motifs were demonstrated to be less problematic than previously suggested. To maximize the diversity of the chemical space sampled in a screening campaign, we therefore consider it justifiable to retain compounds containing PAINS structural motifs that were apparently clean in this analysis when assembling screening libraries.

  15. Determination of Thermal Expansion Coefficients and Locating the Temperature-Induced Phase Transition in Methylammonium Lead Perovskites Using X-ray Diffraction.

    Science.gov (United States)

    Jacobsson, T Jesper; Schwan, L Josef; Ottosson, Mikael; Hagfeldt, Anders; Edvinsson, Tomas

    2015-11-16

    Lead halogen perovskites, and particularly methylammonium lead iodine, CH3NH3PbI3, have recently attracted considerable interest as alternative solar cell materials, and record solar cell efficiencies have now surpassed 20%. Concerns have, however, been raised about the thermal stability of methylammonium lead iodine, and a phase transformation from a tetragonal to a cubic phase has been reported at elevated temperature. Here, this phase transition has been investigated in detail using temperature-dependent X-ray diffraction measurements. The phase transformation is pinpointed to 54 °C, which is well within the normal operating range of a typical solar cell. The cell parameters were extracted as a function of the temperature, from which the thermal expansion coefficient was calculated. The latter was found to be rather high (αv = 1.57 × 10(-4) K(-1)) for both the tetragonal and cubic phases. This is 6 times higher than the thermal expansion coefficient for soda lime glass and CIGS and 11 times larger than that of CdTe. This could potentially be of importance for the mechanical stability of perovskite solar cells in the temperature cycling experienced under normal day-night operation. The experimental knowledge of the thermal expansion coefficients and precise determination of the cell parameters can potentially also be valuable while conducting density functional theory simulations on these systems in order to deliver more accurate band structure calculations.

  16. Identification and function analysis of a novel vascular endothelial growth factor, LvVEGF3, in the Pacific whiteleg shrimp Litopenaeus vannamei.

    Science.gov (United States)

    Wang, Zhiwei; Li, Shihao; Li, Fuhua; Xie, Shijun; Xiang, Jianhai

    2016-10-01

    VEGF signaling pathway is first discovered in mammals and proved to play important roles in the biological processes of angiogenesis, tumor migration, cell differentiation, apoptosis, host-virus interaction etc. Three members in the VEGF signaling pathway, including LvVEGFR, LvVEGF1 and LvVEGF2 in shrimp have been proved to be related with WSSV infection in our previous studies. Currently, another member of VEGF family, LvVEGF3, was isolated and its function during the WSSV infection of shrimp was studied. The deduced amino acid sequence of LvVEGF3 contained a signal peptide, a typical PDGF/VEGF domain and a cysteine-knot motif (CXCXC). Tissue distribution analysis showed that LvVEGF3 was predominantly expressed in hemocytes. The transcriptional level of LvVEGF3 in hemocytes was apparently up-regulated during WSSV infection. Silencing of LvVEGF3 with double-stranded RNA caused a reduction of the cumulative mortality rate of shrimp during WSSV infection. The expression of LvVEGFR was apparently down-regulated after LvVEGF3 silencing and up-regulated after injection of recombinant LvVEGF3 protein, suggesting an interaction between LvVEGF3 and LvVEGFR. Furthermore, the interaction between LvVEGFR and LvVEGF3 was confirmed using the yeast two-hybrid system. The results provided new insights into understanding the role of VEGF signaling pathway during virus infection.

  17. Landslide risk assessment in the Göta Älv river valley to limit consequences of climate change on society

    Science.gov (United States)

    Hedlund, Jonas; Lind, Bo; Tremblay, Marius; Zackrisson, Peter; Cederbom, Charlotte

    2010-05-01

    Higher temperatures, higher average precipitation and increased occurrence of extreme rainfall events are some expected climate changes in Sweden during the coming 70-100 years. Due to the changing climate the risk for floods, erosion and landslides are expected to increase. in large parts of the country. To prevent extensive floodings and damages of cities and infrastructure around Lake Vänern, it is necessary to allow controlled overflow from Lake Vänern through the river Göta Älv. An overflow in the river, in turn, leads to increased risk for erosion and landslides along the Göta Älv valley. In order to meet the upcoming climate changes and to handle the increasing flows through the river, we need to improve the knowledge of the stability of the entire river bank. The Swedish Government has commissioned the Swedish Geotechnical Institute (SGI) to investigate the landslide potential of the Göta Älv valley, taking the predicted climate changes into consideration. The investigated area includes the parts of Göta Älv that could be affected by the increased flows from Lake Vänern; areas where the increased flow will affect stability and where landslides could cause serious damages or damming of the river. The investigation area includes c. 90 km of the Göta Älv river plus tributaries in connection to Göta Älv. In the landslide risk analyses developed for Göta Älv, the likelihood of landslides and estimation of the subsequent consequences are included. The methodology involves mapping of landslide hazards and a judgement of the risk area on the basis of a risk matrix. The landslide risk analysis allows for an assessment of where geotechnical reinforcements would be necessary. A cost estimation for the required reinforcement measures is also provided. In areas where the estimated risk for a landslide is low (e.g. limited consequences), stability mapping in accordance with the model used by the Swedish Civil Contingencies Agency (MSB) is developed

  18. The immune responses triggered by CpG ODNs in shrimp Litopenaeus vannamei are associated with LvTolls.

    Science.gov (United States)

    Sun, Rui; Wang, Mengqiang; Wang, Lingling; Yue, Feng; Yi, Qilin; Huang, Mengmeng; Liu, Rui; Qiu, Limei; Song, Linsheng

    2014-03-01

    CpG oligodeoxynucleotides (ODNs) represent a kind of pathogen-associated molecular patterns (PAMPs) as well as a novel adjuvant that activate the innate immune system through interaction with Toll-like receptor 9 (TLR9) in mammals. In the present study, the synthetic oligodeoxynucleotides, CpG ODN 2395, was employed to investigate the interactive mode of CpG ODNs with three known Tolls (LvToll1-3) from shrimp Litopenaeus vannamei. The mature peptides of extracellular domains of LvTolls (LvToll-ECDs) were recombinant expressed and their binding activities to CpG ODN 2395 were further examined by ELISA. rLvToll1-ECD and rLvToll3-ECD exhibited affinity to CpG ODN 2395 in a dose-dependent manner when their concentrations ranged from 0.25 to 2.00 μmol/L, while rLvToll2-ECD did not show any binding activities to CpG ODN 2395 in tested concentrations. Additionally, after the stimulation of CpG ODN 2395, the luciferase activities of HEK293T cells transfected with LvToll1-mosaic or LvToll3-mosaic were significantly increased to 2.38-fold (pvannamei were indispensable for the triggering of immune responses by CpG ODNs, and the results provided a foundation for the application of CpG ODNs as the novel immunostimulants in aquaculture.

  19. Comparison of three feline leukaemia virus (FeLV) point-of-care antigen test kits using blood and saliva.

    Science.gov (United States)

    Westman, Mark E; Malik, Richard; Hall, Evelyn; Sheehy, Paul A; Norris, Jacqueline M

    2017-02-01

    Feline leukaemia virus (FeLV) can be a challenging infection to diagnose due to a complex feline host-pathogen relationship and occasionally unreliable test results. This study compared the accuracy of three point-of-care (PoC) FeLV p27 antigen test kits commonly used in Australia and available commercially worldwide (SNAP FIV/FeLV Combo, Witness FeLV/FIV and Anigen Rapid FIV/FeLV), using detection of FeLV provirus by an in-house real-time polymerase chain reaction (qPCR) assay as the diagnostic gold standard. Blood (n=563) and saliva (n=419) specimens were collected from a population of cats determined to include 491 FeLV-uninfected and 72 FeLV-infected individuals (45 progressive infections [p27 and qPCR positive], 27 regressive infections [p27 negative, qPCR positive]). Sensitivity and specificity using whole blood was 63% and 94% for SNAP Combo, 57% and 98% for Witness, and 57% and 98% for Anigen Rapid, respectively. SNAP Combo had a significantly lower specificity using blood compared to the other two kits (P=0.004 compared to Witness, P=0.007 compared to Anigen Rapid). False-positive test results occurred with all three kits using blood, and although using any two kits in parallel increased specificity, no combination of kits completely eliminated the occurrence of false-positive results. We therefore recommend FeLV proviral PCR testing for any cat that tests positive with a PoC FeLV antigen kit, as well as for any cat that has been potentially exposed to FeLV but tests negative with a FeLV antigen kit, before final assignment of FeLV status can be made with confidence. For saliva testing, sensitivity and specificity was 54% and 100%, respectively, for all three test kits. The reduced sensitivity of saliva testing compared to blood testing, although not statistically significant, suggests saliva testing with the current generation of PoC FeLV antigen kits is unsuitable for screening large populations of cats, such as in shelters. Copyright © 2016 Elsevier

  20. Analysis of critical operating conditions for LV distribution networks with microgrids

    Science.gov (United States)

    Zehir, M. A.; Batman, A.; Sonmez, M. A.; Font, A.; Tsiamitros, D.; Stimoniaris, D.; Kollatou, T.; Bagriyanik, M.; Ozdemir, A.; Dialynas, E.

    2016-11-01

    Increase in the penetration of Distributed Generation (DG) in distribution networks, raises the risk of voltage limit violations while contributing to line losses. Especially in low voltage (LV) distribution networks (secondary distribution networks), impacts of active power flows on the bus voltages and on the network losses are more dominant. As network operators must meet regulatory limitations, they have to take into account the most critical operating conditions in their systems. In this study, it is aimed to present the impact of the worst operation cases of LV distribution networks comprising microgrids. Simulation studies are performed on a field data-based virtual test-bed. The simulations are repeated for several cases consisting different microgrid points of connection with different network loading and microgrid supply/demand conditions.

  1. Capability to provide reactive power in PV farms. Implementation of LV capacitors

    Energy Technology Data Exchange (ETDEWEB)

    Gal, Isabelle; NGuyen, Minh Quang [Schneider Electric (France)

    2011-07-01

    The latest French grid code assigns a new role to generators connected to the distribution system: they have to contribute to the grid operation by ancillary services, even though they may use renewable energies. Among others, the likely incapacity of such a generator to provide the requested reactive power during steady state operation or during a fault may impose the use of capacitors. For economical reasons, it could be worth installing LV- instead of HV-capacitors. This paper analyses an example photovoltaic fram to evaluate the risks encountered. Results obtained show that the installation of LV capacitors may be possible if very carefully. Indeed, steady state harmonics generated by the inverter can be amplified, and there may be high overvoltages in the installation after upstream switching off. Further analysis should be done to extend the validity of conclusions, but at this stage, installing HV capacitors should be preferred. (orig.)

  2. Short-time Lv transform and its application for non-linear FM signal detection

    Institute of Scientific and Technical Information of China (English)

    Shan Luo; Xiumei Li; Guoan Bi

    2015-01-01

    A new time-frequency transform, known as short-time Lv transform (STLVT), is proposed by applying the inverse Lv dis-tribution to process consecutive segments of long data sequence. Compared with other time-frequency representations, the STLVT is able to achieve better energy concentration in the time-frequency domain for signals containing multiple linear and/or non-linear frequency modulated components. The merits of the STLVT are demonstrated in terms of the effects of window length and overlap length between adjacent segments on signal energy concentra-tion in the time-frequency domain, and the required computational complexity. An application on the spectrum sensing for cognitive ratio (CR) by using a joint use of the STLVT and Hough transform (HT) is proposed and simulated.

  3. Voltage regulation in LV grids by coordinated volt-var control strategies

    DEFF Research Database (Denmark)

    Juamperez Goñi, Miguel Angel; Yang, Guangya; Kjær, Søren Bækhøj

    2014-01-01

    in terms of network power losses and voltage level along the feeder. As a practical implementation, a reconfigurable hardware is used for developing a testing platform based on real-time measurements to regulate the reactive power level. The proposed testing platform has been developed within PVNET......The increasing penetration level of photovoltaic (PV) power generation in low voltage (LV) networks results in voltage rise issues, particularly at the end of the feeders. In order to mitigate this problem, several strategies, such as grid reinforcement, transformer tap change, demand......-side management, active power curtailment, and reactive power optimization methods, show their contribution to voltage support, yet still limited. This paper proposes a coordinated volt-var control architecture between the LV distribution transformer and solar inverters to optimize the PV power penetration level...

  4. Discussion and Analysis on Common Mistakes in LV Circuit Breaker Type Selection%低压断路器选型误区探析

    Institute of Scientific and Technical Information of China (English)

    王殿光

    2016-01-01

    There are various LV circuit breakers with different manufacturers, specifications and models available in the market. Regarding circuit breaker selection and using, there are some common mistakes of users that influence the actual effect. At best, such mistakes result in malfunction and movement resistance; at worst, they lead to life and property loss. From the aspect of product standard, issues like several common mistakes in LV circuit breaker selection: understanding and selection of parameters like Icu, Ics and Icw of LV circuit breaker; relationship between LV circuit breaker’s utilization category and full selective coordination; full and partial selective protections of circuit breakers in series; influence of circuit breaker’s trip value on selective coordination;let-though energy of LV circuit breaker and function of current limiting circuit breaker are illustrated. Suggestions are proposed on the basis of analysis.%市场上低压断路器的制造商众多,规格、型号各异。用户在选择使用断路器上还存在一些误区影响了实际使用效果,轻者误动拒动、重者遭受财产损失危及生命。文章试图从产品标准着眼解释几个主要对低压断路器选择认识的误区:如何理解和选择低压断路器的Ic u、 Ic s、 Ic w等参数,低压断路器的使用类别与全选择性配合的关系,串联断路器间的全选择性和局部选择性保护,断路器脱扣值的误差对选择性配合的影响,低压断路器的允通能量及限流型断路器的作用等,并在分析的基础上给出作者的建议。

  5. Lead fluxes and 206Pb/207Pb isotope ratios in rime and snow collected at remote mountain-top locations (Czech Republic, Central Europe): Patterns and sources

    Science.gov (United States)

    Cimova, Nikoleta; Novak, Martin; Chrastny, Vladislav; Curik, Jan; Veselovsky, Frantisek; Blaha, Vladimir; Prechova, Eva; Pasava, Jan; Houskova, Marie; Bohdalkova, Leona; Stepanova, Marketa; Mikova, Jitka; Krachler, Michael; Komarek, Arnost

    2016-10-01

    During three winter seasons (2009-2011), Pb concentrations were measured in precipitation at 10 high-elevation sites in the Czech Republic, close to the borders with Austria, Germany, Poland, and Slovakia. Soluble and insoluble Pb forms were quantified in snow (vertical deposition), and rime (horizontal deposition). The objective was to compare Pb input fluxes into ecosystems via vertical and horizontal deposition, and to identify the residual Pb pollution sources in an era of rapidly decreasing industrial pollution. Lead soluble in diluted HNO3 made up 96% of total Pb deposition, with the remaining 4% Pb bound mainly in silicates. Three times higher concentrations of soluble Pb in rime than in snow, and 2.5 times higher concentrations of insoluble Pb in rime than in snow were associated with slightly different Pb isotope ratios. On average, the 206Pb/207Pb ratios in rime were higher than those in snow. Higher mean 206Pb/207Pb ratios of insoluble Pb (1.175) than in soluble Pb (1.165) may indicate an increasing role of geogenic Pb in recent atmospheric deposition. A distinct reversal to more radiogenic 206Pb/207Pb ratios in snow and rime in 2010, compared to literature data from rain-fed Sphagnum peatlands (1800-2000 A.D.), documented a recent decrease in anthropogenic Pb in the atmosphere of Central Europe. Since the early 1980s, Pb concentrations in snow decreased 18 times in the rural south of the Czech Republic, but only twice in the industrial north of the Czech Republic. Isotope signatures indicated that Pb in today's atmospheric deposition is mainly derived from Mesozoic ores mined/processed in Poland and coal combustion in the Czech Republic and Poland.

  6. 重组Lv-SWD蛋白的表达、纯化与细菌结合试验%Expression, Purification and Bacteria Binding Test of a Recombinant Lv-SWD Protein

    Institute of Scientific and Technical Information of China (English)

    杜志强; 林涛

    2014-01-01

    The recombinant Lv-SWD protein of Litopenaeus vannamei function in innate immunity system was researched through protein recombinant expression, polyclonal antibody preparation, and bacteria binding assay. The results showed that the predicted molecular weight of Lv-SWD was 12.9 ku, and the virtual molecular weight was consistent with the predicted value. The polyclonal antibody was prepared by recombinant Lv-SWD protein and could identify the protein antigen. The re-combinant Lv-SWD protein could directly bind to Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, and Vibrio.%通过重组Lv-SWD蛋白的表达与纯化,进行多克隆抗体的制备与细菌结合试验,研究凡纳对虾(Litopenaeus vannamei)重组SWD蛋白在先天免疫系统中的功能。结果表明,Lv-SWD的预测分子质量为12.9 ku,实际大小与理论值相符合。重组Lv-SWD蛋白作为抗原制备的多克隆抗体,可以较好地识别蛋白质本身,且可以直接结合巨大芽孢杆菌(Bacillus subtilis)、金黄色葡萄球菌(Staphylococcus aureus)、绿脓杆菌(Pseudomonas aeruginosa)以及弧菌(Vibrio)4种细菌。

  7. A New Protection System for Islanding Detection in LV Distribution Systems

    Directory of Open Access Journals (Sweden)

    Anna Rita Di Fazio

    2015-04-01

    Full Text Available The growth of penetration of Distributed Generators (DGs is increasing the risk of unwanted islanded operation in Low Voltage (LV distribution systems. In this scenario, the existing anti-islanding protection systems, installed at the DG premises and based on classical voltage and frequency relays, are no longer effective, especially in the cases of islands characterized by a close match between generation and load. In this paper, a new protection system for islanding detection in LV distribution systems is proposed. The classical voltage and frequency relays in the DG interface protections are enriched with an innovative Smart Islanding Detector, which adopts a new passive islanding detection method. The aim is to keep the advantages of the classical relays while overcoming the problem of their limited sensitivity in detecting balanced islands. In the paper, to define the requirements of the anti-islanding protection system, the events causing the islanded operation of the LV distribution systems are firstly identified and classified. Then, referring to proposed protection system, its architecture and operation are described and, eventually, its performance is analyzed and validated by experimental laboratory tests, carried out with a hardware-in-the-loop technique.

  8. On the Interpretation of the l-v Features in the Milky Way Galaxy

    Science.gov (United States)

    Baba, Junichi; Saitoh, Takayuki R.; Wada, Keiichi

    2010-12-01

    We modeled the gas dynamics of barred galaxies using a three-dimensional, high-resolution, N-body + hydrodynamical simulation, and applied it to the Milky Way in an attempt to reproduce both the large-scale structure and the clumpy morphology observed in galactic H I and CO l-v diagrams. Owing to including of the multi-phase interstellar medium, self-gravity, star-formation, and supernovae feedback, the clumpy morphology, as well as the large-scale features, in observed l-v diagrams were naturally reproduced. We identified in our l-v diagrams with a number of not only large-scale peculiar features, such as the `3-kpc arm', `135-km s-1 arm', and `Connecting arm', but also clumpy features, such as `Bania clumps', and then linked these features in a face-on view of our model. We give suggestions on the real structure of the Milky Way and on the fate of gas clumps in the central region.

  9. Quantifying grain shape with MorpheoLV: A case study using Holocene glacial marine sediments

    Science.gov (United States)

    Charpentier, Isabelle; Staszyc, Alicia B.; Wellner, Julia S.; Alejandro, Vanessa

    2017-06-01

    As demonstrated in earlier works, quantitative grain shape analysis has revealed to be a strong proxy for determining sediment transport history and depositional environments. MorpheoLV, devoted to the calculation of roughness coefficients from pictures of unique clastic sediment grains using Fourier analysis, drives computations for a collection of samples of grain images. This process may be applied to sedimentary deposits assuming core/interval/image archives for the storage of samples collected along depth. This study uses a 25.8 m jumbo piston core, NBP1203 JPC36, taken from a 100 m thick sedimentary drift deposit from Perseverance Drift on the northern Antarctic Peninsula continental shelf. Changes in ocean and ice conditions throughout the Holocene recorded in this sedimentary archive can be assessed by studying grain shape, grain texture, and other proxies. Ninety six intervals were sampled and a total of 2319 individual particle images were used. Microtextures of individual grains observed by SEM show a very high abundance of authigenically precipitated silica that obscures the original grain shape. Grain roughness, computed along depth with MorpheoLV, only shows small variation confirming the qualitative observation deduced from the SEM. Despite this, trends can be seen confirming the reliability of MorpheoLV as a tool for quantitative grain shape analysis.

  10. Envelope Proteins of White Spot Syndrome Virus (WSSV Interact with Litopenaeus vannamei Peritrophin-Like Protein (LvPT.

    Directory of Open Access Journals (Sweden)

    Shijun Xie

    Full Text Available White spot syndrome virus (WSSV is a major pathogen in shrimp cultures. The interactions between viral proteins and their receptors on the surface of cells in a frontier target tissue are crucial for triggering an infection. In this study, a yeast two-hybrid (Y2H library was constructed using cDNA obtained from the stomach and gut of Litopenaeus vannamei, to ascertain the role of envelope proteins in WSSV infection. For this purpose, VP37 was used as the bait in the Y2H library screening. Forty positive clones were detected after screening. The positive clones were analyzed and discriminated, and two clones belonging to the peritrophin family were subsequently confirmed as genuine positive clones. Sequence analysis revealed that both clones could be considered as the same gene, LV-peritrophin (LvPT. Co-immunoprecipitation confirmed the interaction between LvPT and VP37. Further studies in the Y2H system revealed that LvPT could also interact with other WSSV envelope proteins such as VP32, VP38A, VP39B, and VP41A. The distribution of LvPT in tissues revealed that LvPT was mainly expressed in the stomach than in other tissues. In addition, LvPT was found to be a secretory protein, and its chitin-binding ability was also confirmed.

  11. Envelope Proteins of White Spot Syndrome Virus (WSSV) Interact with Litopenaeus vannamei Peritrophin-Like Protein (LvPT).

    Science.gov (United States)

    Xie, Shijun; Zhang, Xiaojun; Zhang, Jiquan; Li, Fuhua; Xiang, Jianhai

    2015-01-01

    White spot syndrome virus (WSSV) is a major pathogen in shrimp cultures. The interactions between viral proteins and their receptors on the surface of cells in a frontier target tissue are crucial for triggering an infection. In this study, a yeast two-hybrid (Y2H) library was constructed using cDNA obtained from the stomach and gut of Litopenaeus vannamei, to ascertain the role of envelope proteins in WSSV infection. For this purpose, VP37 was used as the bait in the Y2H library screening. Forty positive clones were detected after screening. The positive clones were analyzed and discriminated, and two clones belonging to the peritrophin family were subsequently confirmed as genuine positive clones. Sequence analysis revealed that both clones could be considered as the same gene, LV-peritrophin (LvPT). Co-immunoprecipitation confirmed the interaction between LvPT and VP37. Further studies in the Y2H system revealed that LvPT could also interact with other WSSV envelope proteins such as VP32, VP38A, VP39B, and VP41A. The distribution of LvPT in tissues revealed that LvPT was mainly expressed in the stomach than in other tissues. In addition, LvPT was found to be a secretory protein, and its chitin-binding ability was also confirmed.

  12. Parámetros inmunitaríos en camarones juveniles lv en piscinas camaroneras infectadas con white spot syndrom virus

    OpenAIRE

    Montesdeoca, Bélgica Mercedes; Ibarra, Eulalia; Rodríguez, Jenny

    2002-01-01

    Parámetros inmunitarios en camarones juveniles LV en piscinas camaroneras infectadas con White Spot Syndrom Virus Parámetros inmunitarios en camarones juveniles LV en piscinas camaroneras infectadas con White Spot Syndrom Virus

  13. Location Privacy

    Science.gov (United States)

    Meng, Xiaofeng; Chen, Jidong

    With rapid development of sensor and wireless mobile devices, it is easy to access mobile users' location information anytime and anywhere. On one hand, LBS is becoming more and more valuable and important. On the other hand, location privacy issues raised by such applications have also gained more attention. However, due to the specificity of location information, traditional privacy-preserving techniques in data publishing cannot be used. In this chapter, we will introduce location privacy, and analyze the challenges of location privacy-preserving, and give a survey of existing work including the system architecture, location anonymity and query processing.

  14. Cardiac resynchronization therapy: Dire need for targeted left ventricular lead placement and optimal device programming

    Institute of Scientific and Technical Information of China (English)

    Sokratis; Pastromas; Antonis; S; Manolis

    2014-01-01

    Cardiac resynchronization therapy(CRT) effected via biventricular pacing has been established as prime therapy for heart failure patients of New York Heart Association functional class Ⅱ, Ⅲ and ambulatory Ⅳ, reduced left ventricular(LV) function, and a widened QRS complex. CRT has been shown to improve symptoms, LV function, hospitalization rates, and survival. In order to maximize the benefit from CRT and reduce the number of non-responders, consideration should be given to target the optimal site for LV lead implantation away from myocardial scar and close to the latest LV site activation; and also to appropriately program the device paying particular attention to optimal atrioventricular and interventricular intervals. We herein review current data related to both optimal LV lead placement and device programming and their effects on CRT clinical outcomes.

  15. Left Ventricle: Fully Automated Segmentation Based on Spatiotemporal Continuity and Myocardium Information in Cine Cardiac Magnetic Resonance Imaging (LV-FAST

    Directory of Open Access Journals (Sweden)

    Lijia Wang

    2015-01-01

    Full Text Available CMR quantification of LV chamber volumes typically and manually defines the basal-most LV, which adds processing time and user-dependence. This study developed an LV segmentation method that is fully automated based on the spatiotemporal continuity of the LV (LV-FAST. An iteratively decreasing threshold region growing approach was used first from the midventricle to the apex, until the LV area and shape discontinued, and then from midventricle to the base, until less than 50% of the myocardium circumference was observable. Region growth was constrained by LV spatiotemporal continuity to improve robustness of apical and basal segmentations. The LV-FAST method was compared with manual tracing on cardiac cine MRI data of 45 consecutive patients. Of the 45 patients, LV-FAST and manual selection identified the same apical slices at both ED and ES and the same basal slices at both ED and ES in 38, 38, 38, and 41 cases, respectively, and their measurements agreed within -1.6±8.7 mL, -1.4±7.8 mL, and 1.0±5.8% for EDV, ESV, and EF, respectively. LV-FAST allowed LV volume-time course quantitatively measured within 3 seconds on a standard desktop computer, which is fast and accurate for processing the cine volumetric cardiac MRI data, and enables LV filling course quantification over the cardiac cycle.

  16. Quantifying coronary sinus flow and global LV perfusion at 3T

    Directory of Open Access Journals (Sweden)

    Bloch Karin

    2009-06-01

    Full Text Available Abstract Background Despite the large availability of 3T MR scanners and the potential of high field imaging, this technical platform has yet to prove its usefulness in the cardiac MR setting, where 1.5T remains the established standard. Global perfusion of the left ventricle, as well as the coronary flow reserve (CFR, can provide relevant diagnostic information, and MR measurements of these parameters may benefit from increased field strength. Quantitative flow measurements in the coronary sinus (CS provide one method to investigate these parameters. However, the ability of newly developed faster MR sequences to measure coronary flow during a breath-hold at 3T has not been evaluated. Methods The aim of this work was to measure CS flow using segmented phase contrast MR (PC MR on a clinical 3T MR scanner. Parallel imaging was employed to reduce the total acquisition time. Global LV perfusion was calculated by dividing CS flow with left ventricular (LV mass. The repeatability of the method was investigated by measuring the flow three times in each of the twelve volunteers. Phantom experiments were performed to investigate potential error sources. Results The average CS flow was determined to 88 ± 33 ml/min and the deduced LV perfusion was 0.60 ± 0.22 ml/min·g, in agreement with published values. The repeatability (1-error of the three repeated measurements in each subject was on average 84%. Conclusion This work demonstrates that the combination of high field strength (3T, parallel imaging and segmented gradient echo sequences allow for quantification of the CS flow and global perfusion within a breath-hold.

  17. Reduction of low voltage power cables electromagnetic field emission in MV/LV substations

    Energy Technology Data Exchange (ETDEWEB)

    Beltran San Segundo, Hector [Dpt. Industrial Systems Engineering and Design, Campus del Riu Sec, Universitat Jaume I, 12071 Castello (Spain); Fuster Roig, Vicente [Instituto de Tecnologia Electrica, Avda. Juan de la Cierva 24, Parc Tecnologic de Valencia, 46980 Paterna (Spain)

    2008-06-15

    In this paper a solution to reduce magnetic field emission levels generated by MV/LV substation power cables is proposed. The reduction is obtained by the arrangement of the phases in a proper way and by shielding the cables with magnetic or conductive materials. The effects introduced by these two options have been analyzed by means of simulations, using finite elements method calculation software, and by experimental measurements. The introduced results allow selecting an optimal arrangement and the best screening material in order to reduce the magnetic fields in those directions required to protect. (author)

  18. Clustered PV Inverters in LV Networks: An Overview of Impacts and Comparison of Voltage Control Strategies

    DEFF Research Database (Denmark)

    Demirok, Erhan; Sera, Dezso; Teodorescu, Remus;

    2009-01-01

    and power quality must be maintained or improved by adding cooperative control features to the grid-connected inverters. This paper first gives an overview of bilateral impacts between multiple distributed generations (DG) and grid. Regarding of these impacts, recent advances in static grid voltage support......High penetration of photovoltaic (PV) inverters in low voltage (LV) distribution network challenges the voltage stability due to interaction between multiple inverters and grid. As the main objective is to provide more power injection from VSC-based PV inverters, grid stability, reliability...

  19. Power flow analysis for droop controlled LV hybrid AC-DC microgrids with virtual impedance

    DEFF Research Database (Denmark)

    Li, Chendan; Chaudhary, Sanjay; Vasquez, Juan Carlos

    2014-01-01

    The AC-DC hybrid microgrid is an effective form of utilizing different energy resources and the analysis of this system requires a proper power flow algorithm. This paper proposes a suitable power flow algorithm for LV hybrid AC-DC microgrid based on droop control and virtual impedance. Droop...... and virtual impedance concepts for AC network, DC network and interlinking converter are reviewed so as to model it in the power flow analysis. The validation of the algorithm is verified by comparing it with steady state results from detailed time domain simulation. The effectiveness of the proposed...

  20. Protective effects of Ping-Lv-Mixture (PLM), a medicinal formula on arrhythmias induced by myocardial ischemia-reperfusion.

    Science.gov (United States)

    An, Wei; Yang, Jing

    2006-11-03

    Ping-Lv-Mixture (PLM) is a Chinese medicinal formula. The present study aimed to determine the effects of PLM on myocardial ischemia-reperfusion (MI/R) induced arrhythmias in rats. Arrhythmia model was established by occlusion of the left arterial descending coronary artery and thereafter reperfusion. A lead II electrocardiogram was monitored throughout the experiment. The results showed that pretreatment of PLM to MI/R rats significantly reduced the incidence and duration of ventricular tachycardia and ventricular fibrillation. On induction of MI/R, the activities of creatine kinase and lactate dehydrogenase were increased in vehicle group. PLM (0.04-1.00 g/kg) administration prevented the increase of these enzymes. Moreover, a significant increase of myocardium superoxide dismutase and decrease of malondialdehyde contents were observed in rats of PLM groups. On the other hand, the expressions of platelet activating factor (PAF) receptor mRNA was down-regulated in a dose-dependent manner in the PLM-treated groups by RT-PCR. Thus, it can be concluded that pretreatment with PLM inhibited lipid peroxidation in rats through suppressing the expression of PAF receptor, which may contribute to its preventive effect on myocardial ischemia-reperfusion induced arrhythmias.

  1. High Left Ventricular Lead Sensing Delay Predicts QRS Narrowing and Good Response to Cardiac Resynchronization Therapy.

    Science.gov (United States)

    Kaypakli, Onur; Koç, Mevlüt; Gözübüyük, Gökhan; Şahin, Durmuş Yildiray

    2016-12-01

    Cardiac resynchronization therapy (CRT) was shown to improve heart failure (HF) prognosis. But many patients do not benefit from CRT. Optimization of left ventricular (LV) lead position to the latest activated LV area is important to increase CRT response. We aimed to detect the relationship between LV lead sensing delay and echocardiographic and electrocardiographic response to CRT treatment. We prospectively included 156 consecutive patients with HF diagnosis, QRS ≥ 120 ms, left bundle branch block, New York Heart Association II-IV, LV ejection fraction (LVEF) sensing delay was calculated as the time interval from the onset of surface QRS wave to the onset of depolarization wave recorded from the LV lead by using the LV pacing lead as a bipolar electrode. LVESV reduction was associated with baseline QRS width (r = 0.292, P = 001), QRS narrowing (r = 0.332, P sensing delay (r = 0.454, P sensing delay was found to be the only independent parameter for predicting significant LVESV reduction (β = 0.423, P sensing delay was also found to be significantly associated with LVEF increase (r = 0.320, P sensing delay is the only independent predictor for significant reduction in LVESV and was found to be significantly associated with LVEF increase and QRS narrowing after CRT treatment. We suggest that LV lead sensing delay may be used as a marker to predict the favorable response to CRT. © 2016 Wiley Periodicals, Inc.

  2. An efficient method for accurate segmentation of LV in contrast-enhanced cardiac MR images

    Science.gov (United States)

    Suryanarayana K., Venkata; Mitra, Abhishek; Srikrishnan, V.; Jo, Hyun Hee; Bidesi, Anup

    2016-03-01

    Segmentation of left ventricle (LV) in contrast-enhanced cardiac MR images is a challenging task because of high variability in the image intensity. This is due to a) wash-in and wash-out of the contrast agent over time and b) poor contrast around the epicardium (outer wall) region. Current approaches for segmentation of the endocardium (inner wall) usually involve application of a threshold within the region of interest, followed by refinement techniques like active contours. A limitation of this method is under-segmentation of the inner wall because of gradual loss of contrast at the wall boundary. On the other hand, the challenge in outer wall segmentation is the lack of reliable boundaries because of poor contrast. There are four main contributions in this paper to address the aforementioned issues. First, a seed image is selected using variance based approach on 4D time-frame images over which initial endocardium and epicardium is segmented. Secondly, we propose a patch based feature which overcomes the problem of gradual contrast loss for LV endocardium segmentation. Third, we propose a novel Iterative-Edge-Refinement (IER) technique for epicardium segmentation. Fourth, we propose a greedy search algorithm for propagating the initial contour segmented on seed-image across other time frame images. We have experimented our technique on five contrast-enhanced cardiac MR Datasets (4D) having a total of 1097 images. The segmentation results for all 1097 images have been visually inspected by a clinical expert and have shown good accuracy.

  3. ATP synthase subunit alpha and LV mass in ischaemic human hearts.

    Science.gov (United States)

    Roselló-Lletí, Esther; Tarazón, Estefanía; Barderas, María G; Ortega, Ana; Molina-Navarro, Maria Micaela; Martínez, Alba; Lago, Francisca; Martínez-Dolz, Luis; González-Juanatey, Jose Ramón; Salvador, Antonio; Portolés, Manuel; Rivera, Miguel

    2015-02-01

    Mitochondrial dysfunction plays a critical role in the development of ischaemic cardiomyopathy (ICM). In this study, the mitochondrial proteome in the cardiac tissue of ICM patients was analysed by quantitative differential electrophoresis (2D-DIGE) and mass spectrometry (MS) for the first time to provide new insights into cardiac dysfunction in this cardiomyopathy. We isolated mitochondria from LV samples of explanted hearts of ICM patients (n = 8) and control donors (n = 8) and used a proteomic approach to investigate the variations in mitochondrial protein expression. We found that most of the altered proteins were involved in cardiac energy metabolism (82%). We focused on ATPA, which is involved in energy production, and dihydrolipoyl dehydrogenase, implicated in substrate utilization, and observed that these molecules were overexpressed and that the changes detected in the processes mediated by these proteins were closely related. Notably, we found that ATPA overexpression was associated with reduction in LV mass (r = -0.74, P ATPA could serve as a molecular target suitable for new therapeutic interventions.

  4. Classification of LV wall motion in cardiac MRI using kernel Dictionary Learning with a parametric approach.

    Science.gov (United States)

    Mantilla, Juan; Paredes, Jose; Bellanger, Jean-J; Donal, Erwan; Leclercq, Christophe; Medina, Ruben; Garreau, Mireille

    2015-01-01

    In this paper, we propose a parametric approach for the assessment of wall motion in Left Ventricle (LV) function in cardiac cine-Magnetic Resonance Imaging (MRI). Time-signal intensity curves (TSICs) are identified in Spatio-temporal image profiles extracted from different anatomical segments in a cardiac MRI sequence. Different parameters are constructed from specific TSICs that present a decreasing then increasing shape reflecting dynamic information of the LV contraction. The parameters extracted from these curves are related to: 1) an average curve based on a clustering process, 2) curve skewness and 3) cross correlation values between each average clustered curve and a patient-specific reference. Several tests are performed in order to construct different vectors to train a sparse classifier based on kernel Dictionary Learning (DL). Results are compared with other classifiers like Support Vector Machine (SVM) and Discriminative Dictionary Learning. The best classification performance is obtained with information of skewness and the average curve with an accuracy about 94% using the mentioned sparse based kernel DL with a radial basis function kernel.

  5. Library Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Carnegie Library of Pittsburgh locations including address, coordinates, phone number, square footage, and standard operating hours.

  6. Current status of the Citrus leprosis virus (CiLV -C and its vector Brevipalpus phoenicis (Geijskes

    Directory of Open Access Journals (Sweden)

    Guillermo León M

    2012-08-01

    Full Text Available The Citrus leprosis virus CiLV-C is a quarantine disease of economic importance. Over the past 15 years, this disease has spread to several countries of Central and South America. Colombia has about 45,000 hectares of citrus planted with an annual production of 750,000 tonnes. The CiLV-C has only been detected in the departments of Meta, Casanare and recently Tolima. Meta has 4,300 hectares representing 10% of the national cultivated area, and Casanare, where CiLV-C appeared in 2004, has no more than 500 ha planted with citrus. The presence of the Citrus leprosis virus in Colombia could affect the international market for citrus, other crops and ornamental plants with the United States and other countries without the disease. The false spider mite Brevipalpus phoenicis (Geijskes (Acari: Tenuipalpidae is the main vector of the CiLV-C. Disease management is based on control programs of the vector and diminishing host plants. Chemical mite control is expensive, wasteful and generates resistance to different acaricides. This paper provides basic information on CiLV-C and its vector, advances in diagnosis and methods to control the disease and prevention of its spread

  7. 一种新的LV-BPL宽带通信系统仿真%Simulation of Digital Fountain Concatenated Coding Wavelet-Packet-Based Broadband System in LV-BPL

    Institute of Scientific and Technical Information of China (English)

    杨航; 茹乐; 杜兴民; 唐红

    2007-01-01

    室内低压电力线(LV-BPL)通信是一种新的宽带接入技术,基于数字喷泉码与正交小波包调制提出了一种新的LV-BPL编码多载波调制通信系统模型.系统采用Raptor码作外码,块编码作内码,按块编码调制(BCM)映射到正交小波包调制时频平面.由于小波包稳定的正交性、自由的时频铺砌,数字喷泉码与码率无关的性质及BCM抗脉冲干扰的特点,系统在LV-BPL信道具有比编码DFT-OFDM更好的性能.

  8. Extinction in SC galaxies - an analysis of the ESO-LV data

    Science.gov (United States)

    Huizinga, J. E.; van Albada, T. S.

    1992-02-01

    The surface photometry of Sc galaxies in the ESO-LV database in view of recent claims by Valentijn that spiral galaxies are opaque over their entire disks is analyzed. Using diameter-limited and magnitude-limited subsamples, it can discriminate between the opaque and transparent cases with the axis-ratio distribution test. Results support the traditional view that Sc galaxies are semitransparent, but the brightness difference between face-on and edge-on can be as large as 1.0 to 1.5 mag. Analyzing surface-brightness profiles at various radii, it is seen that the central regions are essentially opaque, and the outer regions nearly fully transparent. It is shown that conclusions differ from those of Valentijn, because of neglect to take secondary inclination effects into account.

  9. Efficient Control of Energy Storage for Increasing the PV Hosting Capacity of LV Grids

    DEFF Research Database (Denmark)

    Hashemi Toghroljerdi, Seyedmostafa; Østergaard, Jacob

    2016-01-01

    hosting capacity of LV grids by determining dynamic set points for EESS management. The method has the effectiveness of central control methods and can effectively decrease the energy storage required for overvoltage prevention, yet it eliminates the need for a broadband and fast communication. The net...... power injected into the grid and the amount of reactive power absorbed by PV inverters are estimated using the PV generation forecast and load consumption forecast, and the dynamic operating points for energy storage management are determined for a specific period of time by solving a linear...... grid is usually limited by overvoltage, and the efficient control of distributed electrical energy storage systems (EESSs) can considerably increase this capacity. In this paper, a new control approach based on the voltage sensitivity analysis is proposed to prevent overvoltage and increase the PV...

  10. Estimation of Maximum Allowable PV Connection to LV Residential Power Networks

    DEFF Research Database (Denmark)

    Demirok, Erhan; Sera, Dezso; Teodorescu, Remus

    2011-01-01

    transformer or using solar inverters with new grid support features. This study presents a methodology for the estimation of maximum PV hosting capacity including IEC 60076-7 based thermal model of distribution transformer. Certain part of a real distribution network of Braedstrup suburban area in Denmark...... is used in simulation as a case study model. Furthermore, varying solutions (utilizing thermally upgraded insulation paper in transformers, reactive power services from solar inverters, etc.) are implemented on the network under investigation to examine PV penetration level and finally key results learnt......Maximum photovoltaic (PV) hosting capacity of low voltage (LV) power networks is mainly restricted by either thermal limits of network components or grid voltage quality resulted from high penetration of distributed PV systems. This maximum hosting capacity may be lower than the available solar...

  11. Curva de rotação óptica de ESO-LV 5100550

    Science.gov (United States)

    Carvalho, D. B.; Soares, D. S. L.

    2003-08-01

    ESO-LV 5100550 é o membro mais fraco do par de galáxias austral SBG 357 (Soares et al. 1995). É classificada no catálogo RC3 como uma espiral ordinária de tipo inicial (early-type); porém, uma análise morfológica sugere que ela tenha uma grande barra. O objetivo do estudo é determinar sua cinemática de tal modo que possamos inferir mais a respeito de sua dinâmica, provavelmente perturbada, já que se espera que esteja sob forte influência da companheira ESO-LV 5100560. Apresentarei resultados parciais determinados a partir de espectros obtidos com o instrumento Double Spectrograph montado no telescópio Hale do Monte Palomar, EUA. As observações foram realizadas por D.S.L. Soares, P.M.V. Veiga e T.E. Nordgren, em 1998. Foram tomados espectros de fenda longa posicionada sobre a linha dos nodos do disco e ao longo da suposta barra. Os dados foram reduzidos com uso do pacote IRAF. Obtivemos o perfil de velocidades radiais na linha de visada ao longo das fendas e calculamos o desvio para o vermelho cosmológico do sistema, com base no espectro central. Determinamos as curvas de rotação deprojetadas, com base em cálculos para os valores teóricos esperados das componentes de velocidades puramente circulares em um disco inclinado. A inclinação do disco, dado fundamental nesta deprojeção, foi estimada através da média das elipticidades das isofotas mais externas.

  12. Decoupled external forces in a predictor-corrector segmentation scheme for LV contours in Tagged MR images.

    Science.gov (United States)

    Garcia-Barnes, Jaume; Andaluz, Albert; Carreras, Francesc; Gil, Debora

    2010-01-01

    Computation of functional regional scores requires proper identification of LV contours. On one hand, manual segmentation is robust, but it is time consuming and requires high expertise. On the other hand, the tag pattern in TMR sequences is a problem for automatic segmentation of LV boundaries. We propose a segmentation method based on a predictor-corrector (Active Contours - Shape Models) scheme. Special stress is put in the definition of the AC external forces. First, we introduce a semantic description of the LV that discriminates myocardial tissue by using texture and motion descriptors. Second, in order to ensure convergence regardless of the initial contour, the external energy is decoupled according to the orientation of the edges in the image potential. We have validated the model in terms of error in segmented contours and accuracy of regional clinical scores.

  13. Coronary venous lead implantation after an evaluation by virtual histology intravascular ultrasound and stenting of a stenosis.

    Science.gov (United States)

    Yamasaki, Hiro; Tada, Hiroshi; Arimoto, Takanori; Sekiguchi, Yukio; Sato, Akira; Aonuma, Kazutaka

    2013-02-01

    We describe a patient who developed coronary vein (CV) stenosis shortly (virtual histological intravascular ultrasound analysis was useful for characterizing the plaque component of the stenotic lesion and formulating the strategy. A summarized review of the CV angioplasty for LV lead implantations disclosed that CV stenosis was often found in patients who had a previous history of cardiac surgery or an LV lead implantation and that a stent implantation was required to deploy the LV lead in the targeted CV in some (9.3%) patients.

  14. Role of multichannel microelectrode recording on location of lead implants for deep brain stimulation%多通道微电极记录在帕金森病脑深部电刺激定位中的作用

    Institute of Scientific and Technical Information of China (English)

    徐欣; 凌至培; 余新光; 潘隆盛; 崔志强; 毛之奇

    2016-01-01

    Objective Subthalamic nucleus ( STN ) was recognized as a major target for deep brain stimulation ( DBS) for Parkinson ' s disease ( PD) .Multichannel microelectrode recording could accurate identify the sensory-motor area of STN , improve the precision and treatment effect of DBS . However , the reports of the method and risk of multichannel microelectrode recording were rare .In 10 patients with PD, multichannel microelectrode recording were used during STN-DBS surgeries, to explore the role and risk of multichannel microelectrode recording on the accurate location of lead implants for DBS.Methods From Oct, 2012 to May, 2013, in 10 patients with PD, multichannel microelectrode recording ( 4-5 channels ) were used during STN-DBS surgeries .Final lead implanted channel was chosen by synchronous scores and the result of macro electrode stimulation . We compared the differences between the predetermined location and the final location of lead implants, and measure the length of channels .Results Different channel recorded neuronal firing pattern , intensity and length of different neuron discharge .The final implanted channels and predet ermined central targets were compared .During left-STN location , central channel was chosen in 6 sides,while non-central channel in 4 sides, including anterior channel in 2 sides ( 20%);lateral channel in 1 side;medial channel in 1 side.During right-STN location,central channel was chosen in 5 sides,while non-central channel in 5 sides,including lateral channel in 4 side;medial channel in 1 side.The average length of the sensory-motor area of left STN activity was 4.85 ±1(3-6 mm), and the average length of the sensory-motor area of right STN activity was 4.83 ±0.7(4-6 mm).There was on significant bleeding complication during total 10 surgeries .Conclusions Only in 50%~60%patients ,predetermined central targetz were chosen , while in 40%~50%patients ,the final implanted targets were inconsistent with the predetermined target

  15. Remediation of Anomia in lvPPA and svPPA

    Directory of Open Access Journals (Sweden)

    Aaron Meyer

    2015-04-01

    Full Text Available Anomia treatment efficacy has been examined in cases with different subtypes of primary progressive aphasia (PPA, and it has been evaluated in groups of participants with the semantic variant (svPPA, but efficacy has not been examined in groups with different subtypes of PPA. Method Participants. Four individuals with the logopenic variant (lvPPA and four individuals with svPPA participated. Procedure. At baseline, participants attempted to name two sets of pictured nouns. One set (Exemplar 1 was utilized during treatment. The second set (Exemplar 2 was never trained and was used to assess stimulus generalization. For each participant, nouns that were consistently named incorrectly were divided among three conditions: Orthographic treatment (OTC, Phonological treatment (PTC, and Untrained (UC. The nouns were matched across conditions for frequency, semantic category, and number of syllables, phonemes, and letters. In the OTC, participants viewed a picture and the corresponding word, read the word out loud, and transcribed the word. In the PTC, participants viewed the picture and a string of symbols. The auditory word was then presented, and participants repeated it. There were two treatment sessions per week during the first month. During the subsequent five months, subjects participated in monthly treatment sessions, in addition to thrice-weekly practice sessions. A post-treatment evaluation began one month after treatment ended. Results lvPPA. From baseline to post-treatment, there was a significant or marginally significant increase in naming accuracy for both exemplars, within every condition [Exemplar 1: UC: t(3 = 2.78, p = .07; PTC: t(3 = 5.75, p = .01; OTC: t(3 = 3.62, p = .04; Exemplar 2: UC: t(3 = 7.82, p = .004; PTC: t(3 = 3.59, p = .04; OTC: t(3 = 3.78, p = .03]. Compared to UC, accuracy at post-treatment was marginally greater for Exemplar 1 in the PTC, t(3 = 3.03, p = .06. There were no other significant or marginally significant

  16. LV305, a dendritic cell-targeting integration-deficient ZVex(TM)-based lentiviral vector encoding NY-ESO-1, induces potent anti-tumor immune response.

    Science.gov (United States)

    Albershardt, Tina Chang; Campbell, David James; Parsons, Andrea Jean; Slough, Megan Merrill; Ter Meulen, Jan; Berglund, Peter

    2016-01-01

    We have engineered an integration-deficient lentiviral vector, LV305, to deliver the tumor antigen NY-ESO-1 to human dendritic cells in vivo through pseudotyping with a modified Sindbis virus envelop protein. Mice immunized once with LV305 developed strong, dose-dependent, multifunctional, and cytotoxic NY-ESO-1-specific cluster of differentiation 8 (CD8) T cells within 14 days post-immunization and could be boosted with LV305 at least twice to recall peak-level CD8 T-cell responses. Immunization with LV305 protected mice against tumor growth in an NY-ESO-1-expressing CT26 lung metastasis model, with the protective effect abrogated upon depletion of CD8 T cells. Adoptive transfer of CD8 T cells, alone or together with CD4 T cells or natural killer cells, from LV305-immunized donor mice to tumor-bearing recipient mice conferred significant protection against metastatic tumor growth. Biodistribution of injected LV305 in mice was limited to the site of injection and the draining lymph node, and injected LV305 exhibited minimal excretion. Mice injected with LV305 developed little to no adverse effects, as evaluated by toxicology studies adherent to good laboratory practices. Taken together, these data support the development of LV305 as a clinical candidate for treatment against tumors expressing NY-ESO-1.

  17. Weltkulturerbe Konstantinbasilika Trier. Wandmalerei in freier Bewitterung als konservatorische Herausforderung (ICOMOS Hefte des Deutschen Nationalkomitees LV), hg. v. Nicole Riedl, Berlin 2013

    OpenAIRE

    Wedekind, Wanja

    2013-01-01

    Weltkulturerbe Konstantinbasilika Trier. Wandmalerei in freier Bewitterung als konservatorische Herausforderung (ICOMOS Hefte des Deutschen Nationalkomitees LV, hg. v. Nicole Riedl, Berlin 2013, rezensiert von Wanja Wedekind

  18. Difficulties in demonstrating long term immunity in FeLV vaccinated cats due to increasing age-related resistance to infection

    Directory of Open Access Journals (Sweden)

    Wilson Stephen

    2012-07-01

    Full Text Available Abstract Background Feline leukaemia virus (FeLV is a pathogen causing fatal illness in cats worldwide, and as such there is a high demand for products to protect against disease. The duration of immunity provided by an inactivated FeLV vaccine, Versifel FeLV, when administered to cats of the target age was determined. Kittens received two vaccinations when aged 7 to 9 weeks old, and were subsequently challenged up to 36 months later with the FeLV-A Glasgow isolate. Results In all studies, all of the younger aged control kittens showed persistent FeLV p27 antigenaemia confirming that the challenge virus was severe and efficacious. In contrast, the control cats did not show the required level of persistent antigenaemia, with a maximum of 45% cats affected in the middle duration study and only 10% in the longer study. However, apart from one animal in the short duration study, all of the cats vaccinated with Versifel FeLV were negative for persistent antigenaemia and can be considered treatment successes. Conclusion In conclusion, we have shown that although age-related resistance to infection with a virulent FeLV challenge is evident from as early as 10 months of age, vaccination with Versifel FeLV may aid in the protection of cats from FeLV related disease up to three years after primary vaccination as kittens.

  19. Molecular characterization of LvAV in response to white spot syndrome virus infection in the Pacific white shrimp (Litopenaeus vannamei).

    Science.gov (United States)

    He, Shulin; Song, Lei; Qian, Zhaoying; Hou, Fujun; Liu, Yongjie; Wang, Xianzong; Peng, Zhangming; Sun, Chengbo; Liu, Xiaolin

    2015-07-01

    Litopenaeus vannamei is the most important farmed shrimp species globally, but its production is affected by several factors, including infectious disease. White spot syndrome virus (WSSV), in particular, causes significant shrimp losses. To understand the shrimp's immune response against WSSV, we cloned LvAV from L. vannamei and analyzed its expression pattern in different tissues, in addition to its expression following infection. We employed dsRNA and recombinant (r)LvAV to explore the potential role of LvAV in shrimp immunity when infected with WSSV. We find that LvAV is a C-type Lectin composed of 176 amino acids with a signal peptide and a specific C-type Lectin-type domain (CTLD). It shares 81% amino acid similarity with PmAV, an antiviral-like C-type Lectin from Penaeus monodom, and it is highly expressed in the hepatopancreas. Its expression is affected by infection with both WSSV and V. parahaemolyticus. Significantly, injection with rLvAV slowed WSSV replication, while injection with LvAV dsRNA initially led to enhanced virus propagation. Surprisingly, LvAV dsRNA subsequently led to a dramatic decrease in viral load in the later stages of infection, suggesting that LvAV may be subverted by WSSV to enhance viral replication or immune avoidance. Our results indicate that LvAV plays an important, but potentially complex role in the Pacific white shrimp's immune defense.

  20. LV305, a dendritic cell-targeting integration-deficient ZVexTM-based lentiviral vector encoding NY-ESO-1, induces potent anti-tumor immune response

    Science.gov (United States)

    Albershardt, Tina Chang; Campbell, David James; Parsons, Andrea Jean; Slough, Megan Merrill; ter Meulen, Jan; Berglund, Peter

    2016-01-01

    We have engineered an integration-deficient lentiviral vector, LV305, to deliver the tumor antigen NY-ESO-1 to human dendritic cells in vivo through pseudotyping with a modified Sindbis virus envelop protein. Mice immunized once with LV305 developed strong, dose-dependent, multifunctional, and cytotoxic NY-ESO-1-specific cluster of differentiation 8 (CD8) T cells within 14 days post-immunization and could be boosted with LV305 at least twice to recall peak-level CD8 T-cell responses. Immunization with LV305 protected mice against tumor growth in an NY-ESO-1-expressing CT26 lung metastasis model, with the protective effect abrogated upon depletion of CD8 T cells. Adoptive transfer of CD8 T cells, alone or together with CD4 T cells or natural killer cells, from LV305-immunized donor mice to tumor-bearing recipient mice conferred significant protection against metastatic tumor growth. Biodistribution of injected LV305 in mice was limited to the site of injection and the draining lymph node, and injected LV305 exhibited minimal excretion. Mice injected with LV305 developed little to no adverse effects, as evaluated by toxicology studies adherent to good laboratory practices. Taken together, these data support the development of LV305 as a clinical candidate for treatment against tumors expressing NY-ESO-1. PMID:27626061

  1. Peritrophin-like protein from Litopenaeus vannamei (LvPT) involved in white spot syndrome virus (WSSV) infection in digestive tract challenged with reverse gavage

    Science.gov (United States)

    Xie, Shijun; Li, Fuhua; Zhang, Xiaojun; Zhang, Jiquan; Xiang, Jianhai

    2017-05-01

    The peritrophic membrane plays an important role in the defense system of the arthropod gut. The digestive tract is considered one of the major tissues targeted by white spot syndrome virus (WSSV) in shrimp. In this study, the nucleotide sequence encoding peritrophin-like protein of Litopenaeus vannamei (LvPT) was amplified from a yeast two-hybrid library of L. vannamei. The epitope peptide of LvPT was predicted with the GenScript OptimumAntigen™ design tool. An anti-LvPT polyclonal antibody was produced and shown to specifically bind a band at 27 kDa, identified as LvPT. The LvPT protein was expressed and its concentration determined. LvPT dsRNA (4 μg per shrimp) was used to inhibit LvPT expression in shrimp, and a WSSV challenge experiment was then performed with reverse gavage. The pleopods, stomachs, and guts were collected from the shrimp at 0, 24, 48, and 72 h post-infection (hpi). Viral load quantification showed that the levels of WSSV were significantly lower in the pleopods, stomachs, and guts of shrimp after LvPT dsRNA interference than in those of the controls at 48 and 72 hpi. Our results imply that LvPT plays an important role during WSSV infection of the digestive tract.

  2. Modelling wetland-groundwater interactions in the boreal Kälväsvaara esker, Northern Finland

    Science.gov (United States)

    Jaros, Anna; Rossi, Pekka; Ronkanen, Anna-Kaisa; Kløve, Bjørn

    2016-04-01

    Many types of boreal peatland ecosystems such as alkaline fens, aapa mires and Fennoscandia spring fens rely on the presence of groundwater. In these ecosystems groundwater creates unique conditions for flora and fauna by providing water, nutrients and constant water temperature enriching local biodiversity. The groundwater-peatland interactions and their dynamics are not, however, in many cases fully understood and their measurement and quantification is difficult due to highly heterogeneous structure of peatlands and large spatial extend of these ecosystems. Understanding of these interactions and their changes due to anthropogenic impact on groundwater resources would benefit the protection of the groundwater dependent peatlands. The groundwater-peatland interactions were investigated using the fully-integrated physically-based groundwater-surface water code HydroGeoSphere in a case study of the Kälväsvaara esker aquifer, Northern Finland. The Kälväsvaara is a geologically complex esker and it is surrounded by vast aapa mire system including alkaline and springs fens. In addition, numerous small springs occur in the discharge zone of the esker. In order to quantify groundwater-peatland interactions a simple steady-state model was built and results were evaluated using expected trends and field measurements. The employed model reproduced relatively well spatially distributed hydrological variables such as soil water content, water depths and groundwater-surface water exchange fluxes within the wetland and esker areas. The wetlands emerged in simulations as a result of geological and topographical conditions. They could be identified by high saturation levels at ground surface and by presence of shallow ponded water over some areas. The model outputs exhibited also strong surface water-groundwater interactions in some parts of the aapa system. These areas were noted to be regions of substantial diffusive groundwater discharge by the earlier studies. In

  3. Extinction in the Galaxy from Surface Brightnesses of ESO-LV Galaxies : Determination of A_R/A_B ratio

    NARCIS (Netherlands)

    Choloniewski, J.; Valentijn, E. A.

    2003-01-01

    A new method for the determination of the extinction in the Galaxy is proposed. The method uses surface brightnesses of external galaxies in the B and R-bands. The observational data have been taken from the ESO-LV galaxy catalog. As a first application of our model we derive the ratio of R-band to

  4. Chemical abundances in the protoplanetary disk LV2 (Orion) - II: High dispersion VLT observations and microjet properties

    CERN Document Server

    Tsamis, Y G

    2011-01-01

    Integral field spectroscopy of the LV2 proplyd is presented taken with the VLT/FLAMES Argus array at an angular resolution of 0.31x0.31 arcsec^2 and velocity resolutions down to 2 km/s per pixel. Following subtraction of the local M42 emission, the spectrum of LV2 is isolated from the surrounding nebula. We measured the heliocentric velocities and widths of a number of lines detected in the intrinsic spectrum of the proplyd, as well as in the adjacent Orion nebula within a 6.6 x 4.2 arcsec^2 FoV. It is found that far-UV to optical collisional lines with critical densities, Ncrit, ranging from 10^3 to 10^9 /cm^3 suffer collisional de-excitation near the rest velocity of the proplyd correlating tightly with their critical densities. Lines of low Ncrit are suppressed the most. The bipolar jet arising from LV2 is spectrally and spatially well-detected in several emission lines. We compute the [O III] electron temperature profile across LV2 in velocity space and measure steep temperature variations associated with...

  5. Toxicity during l-LV/5FU adjuvant chemotherapy as a modified RPMI regimen for patients with colorectal cancer.

    Science.gov (United States)

    Hotta, Tsukasa; Takifuji, Katsunari; Arii, Kazuo; Yokoyama, Shozo; Matsuda, Kenji; Higashiguchi, Takashi; Tominaga, Toshiji; Oku, Yoshimasa; Yamaue, Hiroki

    2005-08-01

    l-leucovorin (LV)/5-fluorouracil (5FU) may play an important role, as an adjuvant chemotherapy, in improving the survival of patients with stage III colorectal cancer. However, severe toxicity of the chemotherapeutic agent could be fatal. Adverse effects, including bone marrow suppression, liver damage, renal damage, and glucose tolerance, were evaluated daily during 3 courses of l-LV/5FU-modified RPMI regimen adjuvant chemotherapy for 22 patients with stage III colorectal cancer. Decrease in the serum levels of neutrophils and platelets occurred in the 1st course, which became more obvious after three or four administrations of l-LV/5FU in the 1st course. Furthermore, serum levels of leukocytes, neutrophils, and platelets on the re-start day of this chemotherapy after 2-week intervals were lower than those on the start day of this chemotherapy. In the evaluation of liver damage, renal damage, and glucose tolerance; serum alanine aminotransferase level in the 2nd course, serum total bilirubin (T.Bil) level in the 1st course, and serum creatinine level in the 1st course deteriorated during the course. T.Bil levels on the re-start day of this chemotherapy after 2-week intervals were especially high compared to that on the start day. The more courses of this chemotherapy we perform, the more attention we must pay to bone marrow suppression and hyperbilirubinemia. Thus, we clarified the attentive point of side effect of l-LV/5FU adjuvant chemotherapy for colorectal cancer.

  6. The Real-Time Optimisation of DNO Owned Storage Devices on the LV Network for Peak Reduction

    Directory of Open Access Journals (Sweden)

    Matthew Rowe

    2014-05-01

    Full Text Available Energy storage is a potential alternative to conventional network reinforcement of the low voltage (LV distribution network to ensure the grid’s infrastructure remains within its operating constraints. This paper presents a study on the control of such storage devices, owned by distribution network operators. A deterministic model predictive control (MPC controller and a stochastic receding horizon controller (SRHC are presented, where the objective is to achieve the greatest peak reduction in demand, for a given storage device specification, taking into account the high level of uncertainty in the prediction of LV demand. The algorithms presented in this paper are compared to a standard set-point controller and bench marked against a control algorithm with a perfect forecast. A specific case study, using storage on the LV network, is presented, and the results of each algorithm are compared. A comprehensive analysis is then carried out simulating a large number of LV networks of varying numbers of households. The results show that the performance of each algorithm is dependent on the number of aggregated households. However, on a typical aggregation, the novel SRHC algorithm presented in this paper is shown to outperform each of the comparable storage control techniques.

  7. Impact of biogenic nanoscale metals Fe, Cu, Zn and Se on reproductive LV chickens

    Science.gov (United States)

    Khiem Nguyen, Quy; Dieu Nguyen, Duy; Kien Nguyen, Van; Thinh Nguyen, Khac; Chau Nguyen, Hoai; Tin Tran, Xuan; Nguyen, Huu Cuong; Tien Phung, Duc

    2015-09-01

    Using biogenic nanoscale metals (Fe, Cu, ZnO, Se) to supplement into diet premix of reproductive LV (a Vietnamese Luong Phuong chicken breed) chickens resulted in certain improvement of poultry farming. The experimental data obtained showed that the farming indices depend mainly on the quantity of nanocrystalline metals which replaced the inorganic mineral component in the feed premix. All four experimental groups with different quantities of the replacement nano component grew and developed normally with livability reaching 91 to 94%, hen’s bodyweight at 38 weeks of age and egg weight ranged from 2.53-2.60 kg/hen and 50.86-51.55 g/egg, respectively. All these farming indices together with laying rate, egg productivity and chick hatchability peaked at group 5 with 25% of nanoscale metals compared to the standard inorganic mineral supplement, while feed consumption was lowest. The results also confirmed that nanocrystalline metals Fe, Cu, ZnO and Se supplemented to chicken feed were able to decrease inorganic minerals in the diet premixes at least four times, allowing animals to more effectively absorb feed minerals, consequently decreasing environmental pollution risks.

  8. Smart MV/LV distribution transformer for Smart Grid with active prosumer participation

    Directory of Open Access Journals (Sweden)

    Marek Adamowicz

    2012-09-01

    Full Text Available With the development of distribution networks and their gradual transformation into intelligent Smart Grid type networks the relevance and share of controlled power converter systems used as interfaces between energy sources and the grid, and between grid and the recipients, will grow. This paper elaborates on the concept of replacing conventional 50 Hz distribution transformers with intelligent distribution transformers. A solution of a three-stage smart distribution transformer of modular design is proposed, oriented to connecting prosumers as active recipients of electricity with enhanced requirements, and owners of small renewable energy systems (RES. Two active stages: AC-DC on the MV side and DC-AC on the LV side provide the ability to compensate reactive power and shape voltage parameters. The simulation results presented here confi rm that the smart transformer’s intermediate stage, through the use of isolated DC-DC converters with high-speed semiconductor devices, provides the ability to quickly adjust the power flow between the primary and secondary sides.

  9. MV and LV Residential Grid Impact of Combined Slow and Fast Charging of Electric Vehicles

    Directory of Open Access Journals (Sweden)

    Niels Leemput

    2015-03-01

    Full Text Available This article investigates the combined low voltage (LV and medium voltage (MV residential grid impact for slow and fast electric vehicle (EV charging, for an increasing local penetration rate and for different residential slow charging strategies. A realistic case study for a Flemish urban distribution grid is used, for which three residential slow charging strategies are modeled: uncoordinated charging, residential off-peak charging, and EV-based peak shaving. For each slow charging strategy, the EV hosting capacity is determined, with and without the possibility of fast charging, while keeping the grid within its operating limits. The results show that the distribution grid impact is much less sensitive to the presence of fast charging compared to the slow charging strategy. EV-based peak shaving results in the lowest grid impact, allowing for the highest EV hosting capacity. Residential off-peak charging has the highest grid impact, due the load synchronization effect that occurs, resulting in the lowest EV hosting capacity. Therefore, the EV users should be incentivized to charge their EVs in a more grid-friendly manner when the local EV penetration rate becomes significant, as this increases the EV hosting capacity much more than the presence of fast charging decreases it.

  10. Characterization and DNA sequence of the mobilization region of pLV22a from Bacteroides fragilis.

    Science.gov (United States)

    Novicki, T J; Hecht, D W

    1995-08-01

    A 4.2-kb plasmid (pLV22a) native to Bacteroides fragilis LV22 became fused to a transfer-deficient Bacteroides spp.-Escherichia coli shuttle vector by an inverse transposition event, resulting in a transferrable phenotype. The transfer phenotype was attributable to pLV22a, which was also capable of mobilization within E. coli when coresident with the IncP beta R751 plasmid. Transposon mutagenesis with Tn1000 localized the mobilization region to a 1.5-kb DNA segment in pLV22a. The mobilization region has been sequenced, and five open reading frames have been identified. Mutants carrying disruptions in any of the three genes designated mbpA, mbpB, and mbpC and coding for deduced products of 11.3, 30.4, and 17.1 kDa, respectively, cannot be mobilized when coresident with R751. Mutations in all three genes can be complemented in the presence of the respective wild-type genes, indicating that the products of mbpA, mbpB, and mbpC have roles in the mobilization process and function in trans. The deduced 30.4-kDa MbpB protein contains a 14-amino-acid conserved motif that is also found in the DNA relaxases of a variety of conjugal and mobilizable plasmids and the conjugative transposon Tn4399. Deletion analysis and complementation experiments have localized a cis-acting region of pLV22a within mbpA.

  11. Shrimp with knockdown of LvSOCS2, a negative feedback loop regulator of JAK/STAT pathway in Litopenaeus vannamei, exhibit enhanced resistance against WSSV.

    Science.gov (United States)

    Wang, Sheng; Song, Xuan; Zhang, Zijian; Li, Haoyang; L, Kai; Yin, Bin; He, Jianguo; Li, Chaozheng

    2016-12-01

    JAK/STAT pathway is one of cytokine signaling pathways and mediates diversity immune responses to protect host from viral infection. In this study, LvSOCS2, a member of suppressor of cytokine signaling (SOCS) families, has been cloned and identified from Litopenaeus vannamei. The full length of LvSOCS2 is 1601 bp, including an 1194 bp open reading frame (ORF) coding for a putative protein of 397 amino acids with a calculated molecular weight of ∼42.3 kDa. LvSOCS2 expression was most abundant in gills and could respond to the challenge of LPS, Vibrio parahaemolyticus, Staphhylococcus aureus, Poly (I: C) and white spot syndrome virus (WSSV). There are several STAT binding motifs presented in the proximal promoter region of LvSOCS2 and its expression was induced by LvJAK or LvSTAT protein in a dose dependent manner, suggesting LvSOCS2 could be the transcriptional target gene of JAK/STAT pathway. Moreover, the transcription of DmVir-1, a read out of the activation of JAK/STAT pathway in Drosophila, was promoted by LvJAK but inhibited by LvSOCS2, indicating that LvSOCS2 could be a negative regulator in this pathway and thus can form a negative feedback loop. Our previous study indicated that shrimp JAK/STAT pathway played a positive role against WSSV. In this study, RNAi-mediated knockdown of LvSOCS2 shrimps showed lower susceptibility to WSSV infection and caused lessened virus loads, which further demonstrated that the JAK/STAT pathway could function as an anti-viral immunity in shrimp.

  12. Acumulación/eliminación de oxitetraciclina en el camarón blanco, lv y su residualidad en dietas artificiales

    OpenAIRE

    Montoya, Nelson; Reyes, Eduardo

    2002-01-01

    Acumulación/eliminación de oxitetraciclina en el camarón blanco, LV y su residualidad en dietas artificiales Acumulación/eliminación de oxitetraciclina en el camarón blanco, LV y su residualidad en dietas artificiales

  13. The Natural History of Left Ventricular Geometry in the Community: Clinical Correlates and Prognostic Significance of Change in LV Geometric Pattern

    Science.gov (United States)

    Lieb, Wolfgang; Gona, Philimon; Larson, Martin G.; Aragam, Jayashri; Zile, Michael R.; Cheng, Susan; Benjamin, Emelia J.; Vasan, Ramachandran S.

    2014-01-01

    Objectives We evaluated pattern and clinical correlates of change in left ventricular (LV) geometry over a 4-year period in the community; we also assessed whether the pattern of change in LV geometry over 4 years predicts incident cardiovascular disease (CVD), including myocardial infarction, heart failure and cardiovascular death during an additional subsequent follow-up period. Background It is unclear how LV geometric patterns change over time and whether changes in LV geometry have prognostic significance. Methods We evaluated 4492 observations (2604 unique Framingham Study participants attending consecutive examinations) to categorize LV geometry at baseline and after 4 years. Four groups were defined based on the sex-specific distributions of LV mass (LVM) and relative wall thickness (RWT) (normal: LVM and RWTgeometric pattern over 4 years was associated with increased CVD risk (140 events) during a subsequent median follow-up of 12.0 years (adjusted-hazards ratio, 1.59; 95%CI, 1.04–2.43). Conclusions Our longitudinal observations in the community suggest that dynamic changes in LV geometric pattern over time are common. Higher blood pressure and greater BMI are modifiable factors associated with the development of abnormal LV geometry, and such progression portends an adverse prognosis. PMID:25129518

  14. La respuesta inmunitaria celular del camarón lv y su utilidad en el control de la enfermedad en estanques

    OpenAIRE

    Motesdeoca, Mercedes; Amano, Yasuji; Echeverría, Fabrizio; Betancourt, Irma; Panchana, Fanny; Sotomayor, Mariuxi; Rodríguez, Jenny

    2002-01-01

    La respuesta inmunitaria celular del camarón LV y su utilidad en el control de la enfermedad en estanques La respuesta inmunitaria celular del camarón LV y su utilidad en el control de la enfermedad en estanques

  15. Lupus vulgaris leading to perforation of nasal septum in a child.

    Science.gov (United States)

    Singal, Archana; Arora, Rahul; Pandhi, Deepika

    2015-01-01

    Lupus vulgaris (LV) is a common form of cutaneous tuberculosis in India, mostly involving the lower half of the body. Facial involvement is uncommon. Untreated disease may lead to significant morbidity due to atrophic scarring, mutilation, and deformity. We report a case of multi-focal LV in a 10-year-old boy affecting the nose and cheek that resulted in perforation of the nasal septum, a rarely reported complication.

  16. SVM-based classification of LV wall motion in cardiac MRI with the assessment of STE

    Science.gov (United States)

    Mantilla, Juan; Garreau, Mireille; Bellanger, Jean-Jacques; Paredes, José Luis

    2015-01-01

    In this paper, we propose an automated method to classify normal/abnormal wall motion in Left Ventricle (LV) function in cardiac cine-Magnetic Resonance Imaging (MRI), taking as reference, strain information obtained from 2D Speckle Tracking Echocardiography (STE). Without the need of pre-processing and by exploiting all the images acquired during a cardiac cycle, spatio-temporal profiles are extracted from a subset of radial lines from the ventricle centroid to points outside the epicardial border. Classical Support Vector Machines (SVM) are used to classify features extracted from gray levels of the spatio-temporal profile as well as their representations in the Wavelet domain under the assumption that the data may be sparse in that domain. Based on information obtained from radial strain curves in 2D-STE studies, we label all the spatio-temporal profiles that belong to a particular segment as normal if the peak systolic radial strain curve of this segment presents normal kinesis, or abnormal if the peak systolic radial strain curve presents hypokinesis or akinesis. For this study, short-axis cine- MR images are collected from 9 patients with cardiac dyssynchrony for which we have the radial strain tracings at the mid-papilary muscle obtained by 2D STE; and from one control group formed by 9 healthy subjects. The best classification performance is obtained with the gray level information of the spatio-temporal profiles using a RBF kernel with 91.88% of accuracy, 92.75% of sensitivity and 91.52% of specificity.

  17. Regulation of FeLV-945 by c-Myb binding and CBP recruitment to the LTR

    Directory of Open Access Journals (Sweden)

    Finstad Samantha L

    2004-09-01

    Full Text Available Abstract Background Feline leukemia virus (FeLV induces degenerative, proliferative and malignant hematologic disorders in its natural host, the domestic cat. FeLV-945 is a viral variant identified as predominant in a cohort of naturally infected animals. FeLV-945 contains a unique sequence motif in the long terminal repeat (LTR comprised of a single copy of transcriptional enhancer followed by a 21-bp sequence triplicated in tandem. The LTR is precisely conserved among independent cases of multicentric lymphoma, myeloproliferative disease and anemia in animals from the cohort. The 21-bp triplication was previously shown to act as a transcriptional enhancer preferentially in hematopoietic cells and to confer a replicative advantage. The objective of the present study was to examine the molecular mechanism by which the 21-bp triplication exerts its influence and the selective advantage responsible for its precise conservation. Results Potential binding sites for the transcription factor, c-Myb, were identified across the repeat junctions of the 21-bp triplication. Such sites would not occur in the absence of the repeat; thus, a requirement for c-Myb binding to the repeat junctions of the triplication would exert a selective pressure to conserve its sequence precisely. Electrophoretic mobility shift assays demonstrated specific binding of c-Myb to the 21-bp triplication. Reporter gene assays showed that the triplication-containing LTR is responsive to c-Myb, and that responsiveness requires the presence of both c-Myb binding sites. Results further indicated that c-Myb in complex with the 21-bp triplication recruits the transcriptional co-activator, CBP, a regulator of normal hematopoiesis. FeLV-945 replication was shown to be positively regulated by CBP in a manner dependent on the presence of the 21-bp triplication. Conclusion Binding sites for c-Myb across the repeat junctions of the 21-bp triplication may account for its precise conservation in

  18. Chemical abundances in the protoplanetary disc LV 2 (Orion) - II. High-dispersion VLT observations and microjet properties

    Science.gov (United States)

    Tsamis, Y. G.; Walsh, J. R.

    2011-11-01

    Integral field spectroscopy of the LV 2 proplyd is presented taken with the Very Large Telescope (VLT)/FLAMES Argus array at an angular resolution of 0.31 × 0.31 arcsec2 and velocity resolutions down to 2 km s-1 pixel-1. Following subtraction of the local M42 emission, the spectrum of LV 2 is isolated from the surrounding nebula. We measured the heliocentric velocities and widths of a number of lines detected in the intrinsic spectrum of the proplyd, as well as in the adjacent Orion nebula falling within a 6.6 × 4.2 arcsec2 field of view. It is found that far-ultraviolet to optical collisional lines with critical densities, Ncr, ranging from 103 to 109 cm-3 suffer collisional de-excitation near the rest velocity of the proplyd correlating tightly with their critical densities. Lines of low Ncr are suppressed the most. The bipolar jet arising from LV 2 is spectrally and spatially well detected in several emission lines. We compute the [O III] electron temperature profile across LV 2 in velocity space and measure steep temperature variations associated with the red-shifted lobe of the jet, possibly being due to a shock discontinuity. From the velocity-resolved analysis the ionized gas near the rest frame of LV 2 has Te= 9200 ± 800 K and Ne˜ 106 cm-3, while the red-shifted jet lobe has Te≈ 9000-104 K and Ne˜ 106-107 cm-3. The jet flow is highly ionized but contains dense semineutral clumps emitting neutral oxygen lines. The abundances of N+, O2 +, Ne2 +, Fe2 +, S+and S2 +are measured for the strong red-shifted jet lobe. Iron in the core of LV 2 is depleted by 2.54 dex with respect to solar as a result of sedimentation on dust, whereas the efficient destruction of dust grains in the fast microjet raises its Fe abundance to at least 30 per cent solar. Sulphur does not show evidence of significant depletion on dust, but its abundance both in the core and the jet is only about half solar. Based on observations made with ESO telescopes at the Paranal Observatory

  19. Feline immunodeficiency virus (FIV, feline leukaemia virus (FeLV and Leishmania sp. in domestic cats in the Midwest of Brazil

    Directory of Open Access Journals (Sweden)

    Daniella Poffo

    Full Text Available ABSTRACT: This search aimed to investigate FIV and FeLV infections in domestic cats, analysing the epidemiological profile of the disease as well as additional infection with Leishmania sp. We evaluated 88 domestic cats for the presence of FIV, FeLV and Leishmania sp. infection. Eleven (12.5% cats were positive for FIV infection, four (4.5% were positive for FeLV, and two were co-infected. However, none was infected with Leishmania sp. The prevalence for FIV infection was higher than FeLV, and those observed in other regions, but no factor was associated with the infection by FIV and FeLV in this study.

  20. 10A1-MuLV but not the related amphotropic 4070A MuLV is highly neurovirulent: importance of sequences upstream of the structural Gag coding region.

    Science.gov (United States)

    Münk, Carsten; Prassolov, Vladimir; Rodenburg, Michaela; Kalinin, Viacheslav; Löhler, Jürgen; Stocking, Carol

    2003-08-15

    Recombinants of Moloney murine leukemia virus (MoMuLV) with either an amphotropic (MoAmphoV) or 10A1-tropic host range (Mo10A1V) induce a spongiform neurodegenerative disease in susceptible mice. To test whether MoMuLV -derived sequences are required for induction of neuropathology, mice were inoculated with either the original 10A1 or the amphotropic (4070A) MuLV isolate. Strikingly, wild-type 10A1 was more neurovirulent than Mo10A1V, inducing severe neurological clinical symptoms with a median latency of 99 days in 100% of infected mice. In contrast, no motor disturbances were detected in any of the 4070A-infected mice, although limited central nervous system lesions were observed. A viral determinant conferring high neurovirulence to 10A1 was mapped to a region encompassing the first 676 bases of the viral genome, including the U5 LTR and encoding the amino-terminus of glycosylated Gag (glycoGag). In contrast to studies with the highly neurovirulent CasFr(KP) virus, an inverse correlation between surface expression levels of glycoGag and neurovirulence was not observed; however, this does not rule out a common underlying mechanism regulating virus pathogenicity.

  1. Zygotic LvBMP5-8 is required for skeletal patterning and for left-right but not dorsal-ventral specification in the sea urchin embryo.

    Science.gov (United States)

    Piacentino, Michael L; Chung, Oliver; Ramachandran, Janani; Zuch, Daniel T; Yu, Jia; Conaway, Evan A; Reyna, Arlene E; Bradham, Cynthia A

    2016-04-01

    Skeletal patterning in the sea urchin embryo requires coordinated signaling between the pattern-dictating ectoderm and the skeletogenic primary mesenchyme cells (PMCs); recent studies have begun to uncover the molecular basis for this process. Using an unbiased RNA-Seq-based screen, we have previously identified the TGF-ß superfamily ligand, LvBMP5-8, as a skeletal patterning gene in Lytechinus variegatus embryos. This result is surprising, since both BMP5-8 and BMP2/4 ligands have been implicated in sea urchin dorsal-ventral (DV) and left-right (LR) axis specification. Here, we demonstrate that zygotic LvBMP5-8 is required for normal skeletal patterning on the left side, as well as for normal PMC positioning during gastrulation. Zygotic LvBMP5-8 is required for expression of the left-side marker soxE, suggesting that LvBMP5-8 is required for left-side specification. Interestingly, we also find that LvBMP5-8 knockdown suppresses serotonergic neurogenesis on the left side. While LvBMP5-8 overexpression is sufficient to dorsalize embryos, we find that zygotic LvBMP5-8 is not required for normal DV specification or development. In addition, ectopic LvBMP5-8 does not dorsalize LvBMP2/4 morphant embryos, indicating that, in the absence of BMP2/4, BMP5-8 is insufficient to specify dorsal. Taken together, our data demonstrate that zygotic LvBMP5-8 signaling is essential for left-side specification, and for normal left-side skeletal and neural patterning, but not for DV specification. Thus, while both BMP2/4 and BMP5-8 regulate LR axis specification, BMP2/4 but not zygotic BMP5-8 regulates DV axis specification in sea urchin embryos.

  2. The real estate of myoblast cardiac transplantation: negative remodeling is associated with location.

    Science.gov (United States)

    McCue, Jonathan D; Swingen, Cory; Feldberg, Tanya; Caron, Gabe; Kolb, Adam; Denucci, Christopher; Prabhu, Somnath; Motilall, Randy; Breviu, Brian; Taylor, Doris A

    2008-01-01

    Skeletal myoblast transplantation has been proposed as a therapy for ischemic cardiomyopathy owing to its possible role in myogenesis. The relative safety and efficacy based on location within scar is not known. We hypothesized that skeletal myoblasts transplanted into peripheral scar (compared with central scar) would more effectively attenuate negative left ventricular (LV) remodeling but at the risk of arrhythmia. New Zealand White rabbits (n = 34) underwent mid-left anterior descending artery (LAD) ligation to produce a transmural LV infarction. One month after LAD ligation, skeletal myoblasts were injected either in the scar center (n = 13) or scar periphery (n = 10) and compared with saline injection (n = 11). Holter monitoring and magnetic resonance imaging (MRI) was performed pre-injection; Holter monitoring was continued until 2 weeks after injection, with follow-up MRI at 1 month. The centrally treated animals demonstrated increased LV end-systolic volume, end-diastolic volume, and mass that correlated with the number of injected cells. There was a trend toward attenuation of negative LV remodeling in peripherally treated animals compared with vehicle. Significant late ectopy was seen in several centrally injected animals, with no late ectopy seen in peripherally injected animals. We noted untoward effects with respect to negative LV remodeling after central injection, suggesting that transplanted cell location with respect to scar may be a key factor in the safety and efficacy of skeletal myoblast cardiac transplantation. Administration of skeletal myoblasts into peripheral scar appears safe, with a trend toward improved function in comparison with sham injection.

  3. Optimization of cDNA amplification of Apricot Latent Virus (ApLV) from various plant tissues sources.

    Science.gov (United States)

    Gumus, M; Sipahioğlu, H M; Paylan, I C; Erkan, S

    2007-03-15

    Although the reverse transcriptase polymerase chain reaction (RT-PCR) procedure is basically simple operation, often it is not possible to achieve optimum results without optimizing the protocols. An RT-PCR method targeting a 200 bp sequence of the CP gene of Apricot Latent Virus (ApLV) was used as a model to improve the detection limit and to compare the behavior of three different plant tissues in a RT-PCR assay. A number of factors should be considered when selecting the optimal system for RT-PCR. Important considerations include the optimal concentrations of MgCl2, dNTP, Taq DNA polymerase enzyme, specific primer and the amount of cDNA for the downstream applications. This study therefore discusses a series of critical PCR parameters and feasible strategies for optimization of RT-PCR detection of ApLV.

  4. Recognizing the fingerprints of the Galactic bar: a quantitative approach to comparing model (l,v) distributions to observation

    CERN Document Server

    Sormani, Mattia C

    2014-01-01

    We present a new method for fitting simple hydrodynamical models to the (l,v) distribution of atomic and molecular gas observed in the Milky Way. The method works by matching features found in models and observations. It is based on the assumption that the large-scale features seen in (l,v) plots, such as ridgelines and the terminal velocity curve, are influenced primarily by the underlying large-scale Galactic potential and are only weakly dependent on local ISM heating and cooling processes. In our scheme one first identifies by hand the features in the observations: this only has to be done once. We describe a procedure for automatically extracting similar features from simple hydrodynamical models and quantifying the "distance" between each model's features and the observations. Application to models of the Galactic Bar region (|l|<30deg) shows that our feature-fitting method performs better than \\chi^2 or envelope distances at identifying the correct underlying galaxy model.

  5. Ulcerative lupus vulgaris over nose, leading to cosmetic deformity.

    Science.gov (United States)

    Nair, Pragya A; Mehta, Malay J; Patel, Bhumi B

    2015-01-01

    Lupus vulgaris (LV), is a chronic and progressive form of secondary cutaneous tuberculosis. In India, it is commonly seen over buttocks, thighs, and legs whereas involvement of nose is quite rare. Ulcerative variant particularly over nose causes destruction of cartilage, leading to irreversible deformities and contracture. High-index of suspicion is required for early diagnosis and prevention of cosmetic deformity. A case of LV over nose in a young male with ulceration is reported who responded well to anti-tubercular therapy, but left with scarring of nose, which could have been prevented if adequate awareness regarding extra-pulmonary cases would have been practiced.

  6. MV/LV PDS transformers: Novel approach for the maximization of the preventive maintenance activities- A case study

    OpenAIRE

    Mahmoudi Morad; El barkany Abdellah; El khalfi Ahmed

    2013-01-01

    In today’s energy market in Morocco, a stable and reliable electric power supply system is an inevitable prerequisite for the technological and economic growth of the kingdom. Due to this, manypublic distribution companies are increasing their competitiveness by adopting new maintenance philosophies to reduce their Operation and Maintenance (O&M) costs. Indeed, being one of the most important parts of the medium voltage network, MV/LV public distribution substations transformer (PDS) play a k...

  7. A Preliminary Analysis of LV Kun's Conception of Sage%吕坤的圣人观浅析

    Institute of Scientific and Technical Information of China (English)

    萧自强

    2011-01-01

    吕坤认为,在圣人的内涵上,圣人能够把握天理,与天理合一,并且能够达到无心而无境的地位,能够超越性情之限制;在圣人的成长上,吕坤认为圣人可以通过修身",克己复礼"而达到;在圣人与众人之关系上,吕坤认为,圣人与众人并不是完全割裂的,圣人即超越于众人,又生活在众人之中。%On the connotation of sage,LV Kun esteemed that sage could grasp the natural principle and united it,got the position without the mind and the state,and went beyond the restrictions of temper.On the growth of the sage,LV Kun thought that sage could be self-cultivation,achieved with "Denying self and observing the proprieties".And on the relationships between the sage and the masses,LV Kun acknowledged that the sage and the masses were not completely separated,namely,the sage transcended the masses,and also,the sage could'nt go beyond them.

  8. Regulation of the immediate-early genes of white spot syndrome virus by Litopenaeus vannamei kruppel-like factor (LvKLF).

    Science.gov (United States)

    Huang, Ping-Han; Lu, Shao-Chia; Yang, Shu-Han; Cai, Pei-Si; Lo, Chu-Fang; Chang, Li-Kwan

    2014-10-01

    Kruppel-like factors (KLFs) belong to a subclass of Cys2/His2 zinc-finger DNA-binding proteins, and act as important regulators with diverse roles in cell growth, proliferation, differentiation, apoptosis and tumorigenesis. Our previous research showed that PmKLF from Penaeus monodon is crucial for white spot syndrome virus (WSSV) infection, yet the mechanisms by which PmKLF influences WSSV infection remain unclear. This study cloned KLF from Litopenaeus vannamei (LvKLF), which had 93% similarity with PmKLF. LvKLF formed a dimer via the C-terminal zinc-finger motif. Knockdown of LvKLF expression by dsRNA injection in WSSV-challenged shrimps was found to significantly inhibit the transcription of two important immediate-early (IE) genes, IE1 and WSSV304, and also reduced WSSV copy numbers. Moreover, reporter assays revealed that the promoter activities of these two WSSV IE genes were substantially enhanced by LvKLF. Mutations introduced in the promoter sequences of IE1 and WSSV304 were shown to abolish LvKLF activation of promoter activities; and an electrophoretic mobility shift assay demonstrated that LvKLF binds to putative KLF-response elements (KRE) in the promoters. Taken together, these results indicate that LvKLF transcriptional regulation of key IE genes is critical to WSSV replication.

  9. Anti-lipopolysaccharide factor in Litopenaeus vannamei (LvALF): a broad spectrum antimicrobial peptide essential for shrimp immunity against bacterial and fungal infection.

    Science.gov (United States)

    de la Vega, Enrique; O'Leary, Nuala A; Shockey, Jessica E; Robalino, Javier; Payne, Caroline; Browdy, Craig L; Warr, Gregory W; Gross, Paul S

    2008-04-01

    Antimicrobial peptides are an essential component of the innate immune system of most organisms. Expressed sequence tag analysis from various shrimp (Litopenaeus vannamei) tissues revealed transcripts corresponding to two distinct sequences (LvALF1 and LvALF2) with strong sequence similarity to anti-lipopolysaccharide factor (ALF), an antimicrobial peptide originally isolated from the horseshoe crab Limulus polyphemus. Full-length clones contained a 528bp transcript with a predicted open reading frame coding for 120 amino acids in LvALF1, and a 623bp transcript with a predicted open reading frame coding for 93 amino acids in LvALF2. A reverse genetic approach was implemented to study the in vivo role of LvALF1 in protecting shrimp from bacterial, fungal and viral infections. Injection of double-stranded RNA (dsRNA) corresponding to the LvALF1 message resulted in a significant reduction of LvALF1 mRNA transcript abundance as determined by qPCR. Following knockdown, shrimp were challenged with low pathogenic doses of Vibrio penaeicida, Fusarium oxysporum or white spot syndrome virus (WSSV) and the resulting mortality curves were compared with controls. A significant increase of mortality in the LvALF1 knockdown shrimp was observed in the V. penaeicida and F. oxysporum infections when compared to controls, showing that this gene has a role in protecting shrimp from both bacterial and fungal infections. In contrast, LvALF1 dsRNA activated the sequence-independent innate anti-viral immune response giving increased protection from WSSV infection.

  10. Variabilidade biológica de isolados do Citrus leprosis virus (CiLV oriundos de cultivares de laranjeira Biological variability of Citrus leprosis virus (CiLV isolates from sweet orange cultivars

    Directory of Open Access Journals (Sweden)

    Jadier de Oliveira Cunha Junior

    2007-09-01

    Full Text Available A leprose, causada pelo Citrus leprosis virus (CiLV, é uma das principais doenças presentes em pomares cítricos fluminenses. O objetivo deste trabalho foi comparar o quadro sintomatológico desenvolvido por isolados de CiLV obtidos de cultivares comerciais de laranjeira (Lima, Pêra e Seleta, inoculados mecanicamente em Chenopodium amaranticolor, em três diluições. Após cinco a sete dias da inoculação foram observadas lesões necróticas, com pequeno halo clorótico quando observadas contra a luz. O maior número de lesões, nas três diluições, foi obtido do isolado de 'Seleta', seguido por 'Pêra' e 'Lima'. A melhor diluição utilizada para a observação das lesões foi de 1:10. Os resultados demonstram uma possível variabilidade biológica entre os isolados virais e/ou uma menor ou maior replicação viral, dependendo da cultivar, indicando um possível mecanismo de resistência da planta ao vírus.Citrus leprosis, caused by Citrus leprosis virus (CiLV is one of the major diseases in citrus orchards in the State of Rio de Janeiro. The objective of this study was to compare the development of symptoms on Chenopodium amaranticolor inoculated with CiLV isolates from 'Lima', 'Pera' and 'Seleta' sweet oranges using three different dilutions. Five to seven-days after inoculation, necrotic lesions exhibiting a small chlorotic halo when exposed to the light, were observed. The highest number of lesions developed using the three dilutions was obtained from 'Seleta', an intermediate value from 'Pêra' and the lowest number from 'Lima'. The best dilution for lesions development was 1:10. The results demonstrate a possible biological variability among the virus isolates and/or a lower or higher viral replication, dependent on the cultivar. This indicates a putative mechanism of Citrus resistance to the virus.

  11. Cardiac pacemaker lead placement: Do you need a lateral chest radiograph?

    Energy Technology Data Exchange (ETDEWEB)

    Sonnex, Emer, E-mail: sonnex@ualberta.c [Department of Radiology and Diagnostic Imaging, University of Alberta Hospitals, Edmonton, Alberta (Canada); Coulden, Richard [Department of Radiology and Diagnostic Imaging, University of Alberta Hospitals, Edmonton, Alberta (Canada)

    2010-08-15

    We present a case of an uneventful dual chamber permanent pacemaker (PPM) implantation which, on the follow-up chest radiograph (CXR), was reported as good lead tip placement and no complications. The patient was re-admitted 7 months later. The PA CXR appearances were unchanged but, in the lateral projection, the ventricular lead tip was projected posteriorly within the heart, most likely within the LV. This was confirmed by CT showing the ventricular lead tip within the LV having passed through a patent foramen ovale (PFO).

  12. A hemocyte-expressed fibrinogen-related protein gene (LvFrep) from the shrimp Litopenaeus vannamei: Expression analysis after microbial infection and during larval development.

    Science.gov (United States)

    Coelho, Jaqueline da Rosa; Barreto, Cairé; Silveira, Amanda da Silva; Vieira, Graziela Cleusa; Rosa, Rafael Diego; Perazzolo, Luciane Maria

    2016-09-01

    Fibrinogen-related proteins (FREPs) comprise a large family of microbial recognition proteins involved in many biological functions in both vertebrate and invertebrate animals. By taking advantage of publicly accessible databases, we have identified a FREP-like homolog in the most cultivated penaeid shrimp, Litopenaeus vannamei (LvFrep). The obtained sequence showed a conserved fibrinogen-related domain (FReD) and displayed significant similarities to FREP-like proteins from other invertebrates and to ficolins from crustaceans. The expression of LvFrep appeared to be limited to circulating hemocytes. Interestingly, LvFrep gene expression was induced in shrimp hemocytes only in response to a Vibrio infection but not to the White spot syndrome virus (WSSV). Moreover, LvFrep transcript levels were detected early in fertilized eggs, suggesting the participation of this immune-related gene in the antimicrobial defenses during shrimp development.

  13. Relationship of basal-septal fibrosis with LV outflow tract obstruction in hypertrophic cardiomyopathy: insights from cardiac magnetic resonance analysis.

    Science.gov (United States)

    Nakamura, Takashi; Iwanaga, Yoshitaka; Yasuda, Masakazu; Kawamura, Takayuki; Miyaji, Yuki; Morooka, Hanako; Miyazaki, Shunichi

    2016-04-01

    Myocardial fibrosis is frequently observed and may be associated with the prognosis in patients with hypertrophic cardiomyopathy (HCM); however, the clinical pathophysiological features, particularly in terms of fibrosis, of hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. This study aimed to determine a role of local fibrosis in HOCM using cardiac magnetic resonance (CMR). 108 consecutive HCM patients underwent CMR. HOCM was defined as a left ventricular outflow tract (LVOT) pressure gradient ≥30 mmHg at rest. Myocardial mass and fibrosis mass by late gadolinium-enhancement CMR (LGE-CMR) were calculated and the distribution/pattern was analyzed using the AHA 17-segment model. LV ejection fraction (LVEF) was significantly higher in patients with HOCM (n = 19) than in those with nonobstructive HCM (n = 89) (P < 0.05). Both total myocardial and fibrosis masses in LV were similar in the two groups (P = 0.385 and P = 0.859, respectively). However, fibrosis in the basal septum was significantly less frequent in the HOCM group than in the nonobstructive HCM group (P < 0.01). The LVOT pressure gradient was significantly higher in the basal-septal non-fibrosis group than in the fibrosis group (23.6 ± 37.3 vs. 4.8 ± 11.4 mmHg, P < 0.01). Multivariate analysis revealed that basal-septal fibrosis was an independent negative predictor of LVOT obstruction in addition to the local wall thickness and LVEF as positive predictors in HCM patients. In conclusion, a significant association was observed between LVOT obstruction and basal septal fibrosis by LGE-CMR in HCM patients. In addition to negative impact of basal-septal fibrosis, basal-septal hypertrophy and preserved global LV contractility may be associated with the pathophysiological features of LVOT obstruction.

  14. Lead levels - blood

    Science.gov (United States)

    Blood lead levels ... A blood sample is needed. Most of the time blood is drawn from a vein located on the inside ... may be used to puncture the skin. The blood collects in a small glass tube called a ...

  15. Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial

    Science.gov (United States)

    Cassidy, J; Douillard, J-Y; Twelves, C; McKendrick, J J; Scheithauer, W; Bustová, I; Johnston, P G; Lesniewski-Kmak, K; Jelic, S; Fountzilas, G; Coxon, F; Díaz-Rubio, E; Maughan, T S; Malzyner, A; Bertetto, O; Beham, A; Figer, A; Dufour, P; Patel, K K; Cowell, W; Garrison, L P

    2006-01-01

    Oral capecitabine (Xeloda®) is an effective drug with favourable safety in adjuvant and metastatic colorectal cancer. Oxaliplatin-based therapy is becoming standard for Dukes' C colon cancer in patients suitable for combination therapy, but is not yet approved by the UK National Institute for Health and Clinical Excellence (NICE) in the adjuvant setting. Adjuvant capecitabine is at least as effective as 5-fluorouracil/leucovorin (5-FU/LV), with significant superiority in relapse-free survival and a trend towards improved disease-free and overall survival. We assessed the cost-effectiveness of adjuvant capecitabine from payer (UK National Health Service (NHS)) and societal perspectives. We used clinical trial data and published sources to estimate incremental direct and societal costs and gains in quality-adjusted life months (QALMs). Acquisition costs were higher for capecitabine than 5-FU/LV, but higher 5-FU/LV administration costs resulted in 57% lower chemotherapy costs for capecitabine. Capecitabine vs 5-FU/LV-associated adverse events required fewer medications and hospitalisations (cost savings £3653). Societal costs, including patient travel/time costs, were reduced by >75% with capecitabine vs 5-FU/LV (cost savings £1318), with lifetime gain in QALMs of 9 months. Medical resource utilisation is significantly decreased with capecitabine vs 5-FU/LV, with cost savings to the NHS and society. Capecitabine is also projected to increase life expectancy vs 5-FU/LV. Cost savings and better outcomes make capecitabine a preferred adjuvant therapy for Dukes' C colon cancer. This pharmacoeconomic analysis strongly supports replacing 5-FU/LV with capecitabine in the adjuvant treatment of colon cancer in the UK. PMID:16622438

  16. LV reverse remodeling imparted by aortic valve replacement for severe aortic stenosis; is it durable? A cardiovascular MRI study sponsored by the American Heart Association

    Directory of Open Access Journals (Sweden)

    Caruppannan Ketheswaram

    2011-04-01

    Full Text Available Abstract Background In patients with severe aortic stenosis (AS, long-term data tracking surgically induced effects of afterload reduction on reverse LV remodeling are not available. Echocardiographic data is available short term, but in limited fashion beyond one year. Cardiovascular MRI (CMR offers the ability to serially track changes in LV metrics with small numbers due to its inherent high spatial resolution and low variability. Hypothesis We hypothesize that changes in LV structure and function following aortic valve replacement (AVR are detectable by CMR and once triggered by AVR, continue for an extended period. Methods Tweny-four patients of which ten (67 ± 12 years, 6 female with severe, but compensated AS underwent CMR pre-AVR, 6 months, 1 year and up to 4 years post-AVR. 3D LV mass index, volumetrics, LV geometry, and EF were measured. Results All patients survived AVR and underwent CMR 4 serial CMR's. LVMI markedly decreased by 6 months (157 ± 42 to 134 ± 32 g/m2, p 2. Similarly, EF increased pre to post-AVR (55 ± 22 to 65 ± 11%,(p 2. LV stroke volume increased rapidly from pre to post-AVR (40 ± 11 to 44 ± 7 ml, p Conclusion After initial beneficial effects imparted by AVR in severe AS patients, there are, as expected, marked improvements in LV reverse remodeling. Via CMR, surgically induced benefits to LV structure and function are durable and, unexpectedly express continued, albeit markedly incomplete improvement through 4 years post-AVR concordant with sustained improved clinical status. This supports down-regulation of both mRNA and MMP activity acutely with robust suppression long term.

  17. Innovation in Cable Outgoing Pattern of LV Cabinets%低压柜电缆出线方式创新

    Institute of Scientific and Technical Information of China (English)

    申景阳

    2015-01-01

    老山自行车馆工程低压柜为上出线方式,低压柜的出线电缆放置在两层1 000 mm × 200 mm的桥架中, 由于出线回路复杂, 上下层桥架中的电缆存在进入同一面低压柜的情况, 特别是1AA1~1AA7, 2AA1~2AA7两列低压柜中集中了场馆近90%的用电负荷, 共需配出百余条供电电缆. 两层配电桥架的设计不可能合理安装上下交错的电缆. 通过自主创新和方案策划, 设计并实施了柜顶配线箱, 有效地解决了低压柜上出线的各种问题, 保证了安装质量和观感效果.%The LV cabinets of Laoshan Velodrome Project are characterized by upper cables outgoing, which are arranged between two layers of 1 000 mm × 200 mm bridging structure. The loop of the outgoing cables is complex, the cable in the upper layer of the bridging structure and that in the lower layer enter the same LV cabinet, and especially 90 % of the electrical loads of Laoshan Velodrome is concentrated in 1AA1~1AA7 and 2AA1~2AA7 LV cabinets, so hundreds of power supply cables are required. The design of two-layer power distribution bridging structure is unable to realize reasonable installation of the cables staggered up and down. Through independent innovation and program planning, a cable distribution box is designed to arrange on the cabinet top to effectively solve various problems caused by upper cables outgoing of LV cabinets and guarantee the installation quality and appearance effect.

  18. FREQUENCY OF THE VIRUS OF THE FELINE LEUKEMIA (FeLV IN DOMESTIC FELINES (Felis catus SEMI-DOMICILED IN THE MUNICIPALITIES OF PELOTAS AND RIO GRANDE FREQUÊNCIA DO Vírus da Leucemia Felina (VLFe em FELINOS DOMÉSTICOS (Felis catus SEMIDOMICILIADOS NOS MUNICÍPIOS DE PELOTAS E RIO GRANDE

    Directory of Open Access Journals (Sweden)

    Dilmara Reischak

    2010-04-01

    Full Text Available Considering the importance of FeLV in the feline clinic, as well as the likely agent spread from a symptomatic or asymptomatic feline bearer, this work has as objective the study of the frequency of FeLV in felines residents in the cities of the Pelotas and Rio Grande, municipalities located in the south area of Brazil. For that, the blood of 120 semi-domiciled animals was collected for the detection of the retrovirus through the Indirect Immunofluorescence technique (IFA. FeLV was detected in 38,3% (46/120 of the studied animals, representing a larger frequency considering other studies accomplished in other areas of Brazil, what confirms the importance of FeLV in the studied region.

    KEY WORDS: FeLV, felines, immunofluorescence, retrovirus.

    Considerando a importância do VLFe na clínica felina, assim como a possível disseminação do agente a partir de um felino portador sintomático ou assintomático, o estudo tem como objetivo verificar a frequência de viremia pelo VLFe em felinos residentes em Pelotas e Rio Grande, municípios situados na região sul do Brasil. Para isso foi coletado sangue de 120 animais semidomiciliados para a detecção do retrovírus através da técnica de imunofluorescência indireta (IFI. Detectou-se a viremia em 38,3% (46/120 dos animais estudados, representando uma frequência maior em relação a outros estudos realizados no Brasil, o que confirma a importância deste agente na região estudada.

    PALAVRAS-CHAVES: Felinos, imunofluorescência, retrovírus, VLFe.

  19. Verbālās metaforas ziņu valodā Latvijas ziņās (ziņu portālos apollo.lv un delfi.lv: 2010–2012)

    OpenAIRE

    Puriņa, Krista

    2013-01-01

    Bakalaura darba „Verbālās metaforas ziņu valodā Latvijas ziņās (ziņu portālos apollo.lv un delfi.lv: 2010–2012)” mērķis ir parādīt, ka ziņu valodā ir daudz metaforas, kuras padara interesantāku vēstījumu, ietekmē tā efektivitāti. Pētnieciskā problēma ir: 1) noskaidrot, vai ziņu valodā ir sastopamas metaforas, 2) kādas, 3) vai to vēstījums nevar tikt uztverts kļūdaini, 4) kas ir vēstījuma efektivitātes pamatā? Teorētiskajā daļā – valoda, semiotika, ziņas, preses relīzes, metaforas Leiko...

  20. Study on the Fermentation Conditions of a Mucopolysaccharide-producing Bacterium LV-1%一株粘性多糖产生菌LV-1的发酵条件研究

    Institute of Scientific and Technical Information of China (English)

    梁玉丽; 郭继强; 陈晓艺; 刘志文; 李宪臻

    2009-01-01

    [Objective] The fermentation conditions of a mucopolysaccharide-producing bacterium LV-1 which isolated from soil sample were studied.[Method] The polysaccharide-producing bacterium was isolated by serial dilution method, the effects of carbon source, nitrogen source, the initial pH and temperature on producing polysaccharide by it were discussed to confirm the optimum fermentation conditions.[Result] The physicochemical properties showed that the polysaccharide was water-soluble, but insoluble in organic solvents including ethanol, butanol, and chloroform.It was neutral polysaccharide with negative charge and without reducing terminal. The pH of its solution was pH=7.5. There were no protein, fructose, uronic acid, sulphate and starch-like structure included in polysaccharide molecules. The optimum fermentation conditions for polysaccharide production were 3% mannitol as carbon source, 0.25% yeast extract as nitrogen source, culture temperature 28 ℃ and pH=7.5. [Conclusion] The research could provie basis for development and utilization of LV-1 and industrialized production of mucopolysaccharide.

  1. Interneta sociālie tīkli draugiem.lv, mammam/tetiem.lv un twitter.com kā reklāmas nesēji Latvijā (2009.gads)

    OpenAIRE

    2010-01-01

    Maģistra darba tēma ir „Interneta sociālie tīkli draugiem.lv, mammam/tetiem.lv un twitter.com kā reklāmas nesēji Latvijā (2009.gads)”. Darba mērķis ir izpētīt Latvijas interneta sociālo tīklu vidi kā potenciāli augošu un reklāmai piemērotu, kā arī izpētīt pamanāmākos reklāmas gadījumus šajos portālos. Teorijas daļā tiek apskatīta Web 2.0 ēra, interneta reklāmas un sociālo mediju mārketinga īpatnības, sociālo tīklu fenomens un teorijas, Latvijas reklāmas tirgus un auditorija, kā arī sociāl...

  2. Litopenaeus vannamei sterile-alpha and armadillo motif containing protein (LvSARM is involved in regulation of Penaeidins and antilipopolysaccharide factors.

    Directory of Open Access Journals (Sweden)

    Pei-Hui Wang

    Full Text Available The Toll-like receptor (TLR-mediated NF-κB pathway is tightly controlled because overactivation may result in severe damage to the host, such as in the case of chronic inflammatory diseases and cancer. In mammals, sterile-alpha and armadillo motif-containing protein (SARM plays an important role in negatively regulating this pathway. While Caenorhabditis elegans SARM is crucial for an efficient immune response against bacterial and fungal infections, it is still unknown whether Drosophila SARM participates in immune responses. Here, Litopenaeus vannamei SARM (LvSARM was cloned and functionally characterized. LvSARM shared signature domains with and exhibited significant similarities to mammalian SARM. Real-time quantitative PCR analysis indicated that the expression of LvSARM was responsive to Vibrio alginolyticus and white spot syndrome virus (WSSV infections in the hemocyte, gill, hepatopancreas and intestine. In Drosophila S2 cells, LvSARM was widely distributed in the cytoplasm and could significantly inhibit the promoters of the NF-κB pathway-controlled antimicrobial peptide genes (AMPs. Silencing of LvSARM using dsRNA-mediated RNA interference increased the expression levels of Penaeidins and antilipopolysaccharide factors, which are L.vannamei AMPs, and increased the mortality rate after V. alginolyticus infection. Taken together, our results reveal that LvSARM may be a novel component of the shrimp Toll pathway that negatively regulates shrimp AMPs, particularly Penaeidins and antilipopolysaccharide factors.

  3. Litopenaeus vannamei sterile-alpha and armadillo motif containing protein (LvSARM) is involved in regulation of Penaeidins and antilipopolysaccharide factors.

    Science.gov (United States)

    Wang, Pei-Hui; Gu, Zhi-Hua; Wan, Ding-Hui; Zhu, Wei-Bin; Qiu, Wei; Weng, Shao-Ping; Yu, Xiao-Qiang; He, Jian-Guo

    2013-01-01

    The Toll-like receptor (TLR)-mediated NF-κB pathway is tightly controlled because overactivation may result in severe damage to the host, such as in the case of chronic inflammatory diseases and cancer. In mammals, sterile-alpha and armadillo motif-containing protein (SARM) plays an important role in negatively regulating this pathway. While Caenorhabditis elegans SARM is crucial for an efficient immune response against bacterial and fungal infections, it is still unknown whether Drosophila SARM participates in immune responses. Here, Litopenaeus vannamei SARM (LvSARM) was cloned and functionally characterized. LvSARM shared signature domains with and exhibited significant similarities to mammalian SARM. Real-time quantitative PCR analysis indicated that the expression of LvSARM was responsive to Vibrio alginolyticus and white spot syndrome virus (WSSV) infections in the hemocyte, gill, hepatopancreas and intestine. In Drosophila S2 cells, LvSARM was widely distributed in the cytoplasm and could significantly inhibit the promoters of the NF-κB pathway-controlled antimicrobial peptide genes (AMPs). Silencing of LvSARM using dsRNA-mediated RNA interference increased the expression levels of Penaeidins and antilipopolysaccharide factors, which are L.vannamei AMPs, and increased the mortality rate after V. alginolyticus infection. Taken together, our results reveal that LvSARM may be a novel component of the shrimp Toll pathway that negatively regulates shrimp AMPs, particularly Penaeidins and antilipopolysaccharide factors.

  4. Lead Poisoning

    Science.gov (United States)

    Lead is a metal that occurs naturally in the earth's crust. Lead can be found in all parts of our ... from human activities such as mining and manufacturing. Lead used to be in paint; older houses may ...

  5. Interaction between endoplasmic reticulum stress and caspase 8 activation in retrovirus MoMuLV-ts1-infected astrocytes.

    Science.gov (United States)

    Liu, Na; Scofield, Virginia L; Qiang, Wenan; Yan, Mingshan; Kuang, Xianghong; Wong, Paul K Y

    2006-05-10

    The murine retrovirus, MoMuLV-ts1, induces progressive paralysis and immune deficiency in FVB/N mice. We have reported previously that ts1 infection causes apoptosis in astrocytes via endoplasmic reticulum (ER) and mitochondrial stress (Liu, N., Kuang, X., Kim, H.T., Stoica, G., Qiang, W., Scofield, V.L., Wong, P.K.Y. Wong. 2004. Possible involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in MoMuLV-ts1-induced apoptosis in astrocytes. J. NeuroVirol. 10, 189-198). In the present study, we show that caspase 8 activation in these cells is mediated through ER stress-associated elevation of death receptor DR5 and the C/EBP homologous protein (GADD153/CHOP), an ER stress-initiated transcription factor, rather than through TNFalpha and TNF-R1 interactions on the cell surface. Treatment with Z-IETD-FMK, a specific inhibitor of caspase 8 enzymatic activity, reduced ER stress by two mechanisms: by inhibiting caspase 8 activation, and by preventing cleavage of the ER-associated membrane protein BAP31 into BAP20, which exacerbates the ER stress response. These findings suggest that caspase 8- and ER stress-associated apoptotic pathways are linked in ts1-infected astrocytes.

  6. New method for cardiac resynchronization therapy: Transapical endocardial lead implantation for left ventricular free wall pacing

    NARCIS (Netherlands)

    I. Kassai (Imre); C. Foldesi (Csaba); A. Szekely (Andrea); T. Szili-Torok (Tamas)

    2008-01-01

    textabstractCoronary sinus lead placement for transvenous left ventricular (LV) pacing in cardiac resynchronization therapy (CRT) has a significant failure rate at implant and a significant dislocation rate during follow-up. For these patients, epicardial pacing lead implantation is the most frequen

  7. New method for cardiac resynchronization therapy: Transapical endocardial lead implantation for left ventricular free wall pacing

    NARCIS (Netherlands)

    I. Kassai (Imre); C. Foldesi (Csaba); A. Szekely (Andrea); T. Szili-Torok (Tamas)

    2008-01-01

    textabstractCoronary sinus lead placement for transvenous left ventricular (LV) pacing in cardiac resynchronization therapy (CRT) has a significant failure rate at implant and a significant dislocation rate during follow-up. For these patients, epicardial pacing lead implantation is the most

  8. Jag kan själv : Spelmanualer för mellanstadiebarn

    OpenAIRE

    Svedblom, Ronja

    2013-01-01

    Todays board game manuals have many shortcomings. One of them is that they are not always adapted to the game's target audience. Adapting the language and shape of a game manual for the the target group children, can save time for both parents and teachers, and give the children a chance to conquer the game by themselves. In addition, playing board games can lead to children developing other important properties such as problem solving and independence. This study found that the game manuals ...

  9. Lead Toxicity

    Science.gov (United States)

    ... including some imported jewelry. What are the health effects of lead? • More commonly, lower levels of lead in children over time may lead to reduced IQ, slow learning, Attention Deficit Hyperactivity Disorder (ADHD), or behavioral issues. • Lead also affects other ...

  10. No Evidence of XMRV or MuLV Sequences in Prostate Cancer, Diffuse Large B-Cell Lymphoma, or the UK Blood Donor Population

    Directory of Open Access Journals (Sweden)

    Mark James Robinson

    2011-01-01

    Full Text Available Xenotropic murine leukaemia virus-related virus (XMRV is a recently described retrovirus which has been claimed to infect humans and cause associated pathology. Initially identified in the US in patients with prostate cancer and subsequently in patients with chronic fatigue syndrome, doubt now exists that XMRV is a human pathogen. We studied the prevalence of genetic sequences of XMRV and related MuLV sequences in human prostate cancer, from B cell lymphoma patients and from UK blood donors. Nucleic acid was extracted from fresh prostate tissue biopsies, formalin-fixed paraffin-embedded (FFPE prostate tissue and FFPE B-cell lymphoma. The presence of XMRV-specific LTR or MuLV generic gag-like sequences was investigated by nested PCR. To control for mouse DNA contamination, a PCR that detected intracisternal A-type particle (IAP sequences was included. In addition, DNA and RNA were extracted from whole blood taken from UK blood donors and screened for XMRV sequences by real-time PCR. XMRV or MuLV-like sequences were not amplified from tissue samples. Occasionally MuLV gag and XMRV-LTR sequences were amplified from Indian prostate cancer samples, but were always detected in conjunction with contaminating murine genomic DNA. We found no evidence of XMRV or MuLV infection in the UK blood donors.

  11. The Mus cervicolor MuLV isolate M813 is highly fusogenic and induces a T-cell lymphoma associated with large multinucleated cells.

    Science.gov (United States)

    Prassolov, V; Ivanov, D; Hein, S; Rutter, G; Münk, C; Löhler, J; Stocking, C

    2001-11-10

    M813 is a type-C murine leukemia virus (MuLV) isolated from the Asian rodent Mus cervicolor. We have recently demonstrated that M813 defines a distinct MuLV receptor interference group. Here we show that M813 rapidly induces fusion of MuLV-expressing fibroblasts from "without," with syncytia being observed within 1 h after exposure to virus. Infection of fibroblasts with MuLV from all tested receptor-interference groups imparts susceptibility to M813-induced fusion, provided the cells also express the M813 receptor. Syncytium induction is also observed in vivo; mice infected with M813 develop a peripheral T-cell lymphoma, which is associated with large multinucleated cells of macrophage origin. A recombinant Moloney MuLV/M813 chimeric virus demonstrated that syncytium induction is a function of the Env SU protein. We postulate that the highly fusogenic property of M813 is attributable to either its unique receptor usage or sequences in the proline-rich domain of the Env protein.

  12. Regional assessment of LV wall in infarcted heart using tagged MRI and cardiac modelling

    Science.gov (United States)

    Jahanzad, Zeinab; Miin Liew, Yih; Bilgen, Mehmet; McLaughlin, Robert A.; Onn Leong, Chen; Chee, Kok Han; Aziz, Yang Faridah Abdul; Ung, Ngie Min; Lai, Khin Wee; Ng, Siew-Cheok; Lim, Einly

    2015-05-01

    A segmental two-parameter empirical deformable model is proposed for evaluating regional motion abnormality of the left ventricle. Short-axis tagged MRI scans were acquired from 10 healthy subjects and 10 postinfarct patients. Two motion parameters, contraction and rotation, were quantified for each cardiac segment by fitting the proposed model using a non-rigid registration algorithm. The accuracy in motion estimation was compared to a global model approach. Motion parameters extracted from patients were correlated to infarct transmurality assessed with delayed-contrast-enhanced MRI. The proposed segmental model allows markedly improved accuracy in regional motion analysis as compared to the global model for both subject groups (1.22-1.40 mm versus 2.31-2.55 mm error). By end-systole, all healthy segments experienced radial displacement by ~25-35% of the epicardial radius, whereas the 3 short-axis planes rotated differently (basal: 3.3° mid:  -1° and apical:  -4.6°) to create a twisting motion. While systolic contraction showed clear correspondence to infarct transmurality, rotation was nonspecific to either infarct location or transmurality but could indicate the presence of functional abnormality. Regional contraction and rotation derived using this model could potentially aid in the assessment of severity of regional dysfunction of infarcted myocardium.

  13. Pressure Transducer Locations

    Data.gov (United States)

    National Aeronautics and Space Administration — Files are located here, defining the locations of the pressure transducers on the HIRENASD model. These locations also correspond to the locations that analysts...

  14. Lead Poisoning

    Science.gov (United States)

    ... lead is of microscopic size, invisible to the naked eye. More often than not, children with elevated ... majority of the childhood lead poisoning cases we see today. Children and adults too can get seriously ...

  15. Relational Leading

    DEFF Research Database (Denmark)

    2015-01-01

    This first chapter presents the exploratory and curious approach to leading as relational processes – an approach that pervades the entire book. We explore leading from a perspective that emphasises the unpredictable challenges and triviality of everyday life, which we consider an interesting......, relevant and realistic way to examine leading. The chapter brings up a number of concepts and contexts as formulated by researchers within the field, and in this way seeks to construct a first understanding of relational leading....

  16. Radiation Characterization Summary: ACRR Polyethylene-Lead-Graphite (PLG) Bucket Located in the Central Cavity on the 32-Inch Pedestal at the Core Centerline (ACRR-PLG-CC-32-cl).

    Energy Technology Data Exchange (ETDEWEB)

    Parma, Edward J.,; Vehar, David W.; Lippert, Lance L.; Griffin, Patrick J.; Naranjo, Gerald E.; Luker, Spencer M.

    2015-06-01

    This document presents the facility-recommended characterization of the neutron, prompt gamma-ray, and delayed gamma-ray radiation fields in the Annular Core Research Reactor (ACRR) for the polyethylene-lead-graphite (PLG) bucket in the central cavity on the 32-inch pedestal at the core centerline. The designation for this environment is ACRR-PLG-CC-32-cl. The neutron, prompt gamma-ray, and delayed gamma-ray energy spectra, uncertainties, and covariance matrices are presented as well as radial and axial neutron and gamma-ray fluence profiles within the experiment area of the bucket. Recommended constants are given to facilitate the conversion of various dosimetry readings into radiation metrics desired by experimenters. Representative pulse operations are presented with conversion examples. Acknowledgements The authors wish to thank the Annular Core Research Reactor staff and the Radiation Metrology Laboratory staff for their support of this work. Also thanks to David Ames for his assistance in running MCNP on the Sandia parallel machines.

  17. Alexa Fluor 546-ArIB[V11L;V16A] is a potent ligand for selectively labeling alpha 7 nicotinic acetylcholine receptors.

    Science.gov (United States)

    Hone, Arik J; Whiteaker, Paul; Mohn, Jesse L; Jacob, Michele H; McIntosh, J Michael

    2010-08-01

    The alpha7* (*denotes the possible presence of additional subunits) nicotinic acetylcholine receptor (nAChR) subtype is widely expressed in the vertebrate nervous system and implicated in neuropsychiatric disorders that compromise thought and cognition. In this report, we demonstrate that the recently developed fluorescent ligand Cy3-ArIB[V11L;V16A] labels alpha7 nAChRs in cultured hippocampal neurons. However, photobleaching of this ligand during long image acquisition times prompted us to develop a new derivative. In photostability studies, this new ligand, Alexa Fluor 546-ArIB[V11L;V16A], was significantly more resistant to bleaching than the Cy3 derivative. The classic alpha7 ligand alpha-bungarotoxin binds to alpha1* and alpha9* nAChRs. In contrast, Alexa Fluor 546-ArIB[V11L;V16A] potently (IC(50) 1.8 nM) and selectively blocked alpha7 nAChRs but not alpha1* or alpha9* nAChRs expressed in Xenopus oocytes. Selectivity was further confirmed by competition binding studies of native nAChRs in rat brain membranes. The fluorescence properties of Alexa Fluor 546-ArIB[V11L;V16A] were assessed using human embryonic kidney-293 cells stably transfected with nAChRs; labeling was observed on cells expressing alpha7 but not cells expressing alpha3beta2, alpha3beta4, or alpha4beta2 nAChRs. Further imaging studies demonstrate that Alexa Fluor 546-ArIB[V11L;V16A] labels hippocampal neurons from wild-type mice but not from nAChR alpha7 subunit-null mice. Thus, Alexa Fluor 546-ArIB[V11L;V16A] represents a potent and selective ligand for imaging alpha7 nAChRs.

  18. Crossing the bends: Support-catheter based left ventricular lead placement in challenging cardiac resynchronization therapy device implantation

    Directory of Open Access Journals (Sweden)

    Amit Kumar Malik, MBBS, MD

    2012-08-01

    Full Text Available The combined use of an Amplatz guiding catheter and support catheter creates a progressively supportive rail to implant the left ventricular (LV lead in difficult cardiac resynchronization therapy device implantation. We describe the case of a 32-year-old male with non-ischaemic cardiomyopathy, left bundle-branch block, and an LV ejection fraction of 30%, who was referred to our centre for a repeat attempt at an LV lead implant. Previously, the implanter had been unable to advance different guide catheters over the wire to the desired tributary of the coronary sinus (CS. At our centre, the CS was cannulated with a 6-Fr AL2 coronary guiding catheter. A 135-cm support catheter (Spectranetics Quick-Cross was advanced via AL2 guiding over the 0.035 in. guide wire to the distal CS. The proximal luer fitting of the support catheter was cut and an inner sheath (Medtronic ATTAIN SELECT II advanced over the support catheter into the CS. A 4-Fr over-the-wire LV lead was advanced through the inner sheath over a 0.014 in. percutaneous transluminal coronary angioplasty wire after removal of the support catheter. The use of a support catheter serves as rail for the placement of the inner sheath deep in the CS and facilitates implantation of the LV pacing lead. This technique is safe and easily applied.

  19. TEE-guided left ventricular epicardial pacing lead placement for cardiac resynchronization therapy

    Directory of Open Access Journals (Sweden)

    Rajesh Chand Arya

    2012-01-01

    Full Text Available Biventricular pacing has demonstrated improvement in cardiac functions in treating congestive cardiac failure patients. Recent trials have proven the clinical and functional benefits of cardiac resynchronization therapy in severe heart failure and intraventricular cardiac delays, mainly left bundle branch block. Biventricular pacing improves the exercise tolerance, quality of life, systolic heart function, reduces hospitalization and slows progression of the disease. A 54-year-old lady, a known case of dilated cardiomyopathy, was on biventricular pacing since 2 years. She presented in emergency with sudden deterioration of dyspnea to NYHA class III/IV. When investigated, the coronary sinus lead was found displaced; thus, left ventricle (LV was not getting paced. After multiple failures to reposition the coronary sinus lead, it was decided to surgically place the epicardial lead for LV pacing under general anesthesia. Lateral thoracotomy was done and LV pacing lead was placed at different sites with simultaneous monitoring of cardiac output (CO and stroke volume (SV by transesophageal echocardiography (TEE. Baseline CO and SV were 1.9 l/min and 19.48 ml respectively and increased at different sites of pacing at LV, the best CO and SV were 4.2 l/min and 42.39 ml respectively on lateral surface. Intraoperative TEE can calculate beat to beat stroke volume and thus CO and helps to choose optimal site for placement of epicardial pacing lead.

  20. The Use of a Quadripolar Left Ventricular Lead Increases Successful Implantation Rates in Patients with Phrenic Nerve Stimulation and/or High Pacing Thresholds Undergoing Cardiac Resynchronisation Therapy with Conventional Bipolar Leads

    Directory of Open Access Journals (Sweden)

    Marc-Alexander Ohlow, MD

    2013-03-01

    Conclusions: Excessively HPT and/or PNS are frequently encountered when conventional bipolar leads are used for CRT. A new quadripolar LV lead increases the rate of successful biventricular stimulation. Lower pacing threshold and freedom from PNS are maintained at follow-up.

  1. Lead Test

    Science.gov (United States)

    ... months, and at 3, 4, 5, and 6 years of age. A blood lead level test should be done only if the risk ... recommended if the person is symptomatic at any level below 70 mcg/dL. Because lead will pass through the blood to an unborn child, pregnant ...

  2. A novel approach for endocardial resynchronization therapy: Initial experience with transapical implantation of the left ventricular lead

    NARCIS (Netherlands)

    I. Kassai (Imre); A. Mihalcz (Attila); C. Foldesi (Csaba); A. Kardos (Attila); T. Szili-Torok (Tamas)

    2009-01-01

    textabstractBackground: Coronary sinus lead placement for transvenous left ventricular (LV) pacing in cardiac resynchronization therapy (CRT) has a significant failure rate at implant and a considerable dislocation rate during follow-up. For these patients epicardial pacing lead implantation is the

  3. A novel approach for endocardial resynchronization therapy: Initial experience with transapical implantation of the left ventricular lead

    NARCIS (Netherlands)

    I. Kassai (Imre); A. Mihalcz (Attila); C. Foldesi (Csaba); A. Kardos (Attila); T. Szili-Torok (Tamas)

    2009-01-01

    textabstractBackground: Coronary sinus lead placement for transvenous left ventricular (LV) pacing in cardiac resynchronization therapy (CRT) has a significant failure rate at implant and a considerable dislocation rate during follow-up. For these patients epicardial pacing lead implantation is the

  4. A Location Privacy Aware Friend Locator

    DEFF Research Database (Denmark)

    Siksnys, Laurynas; Thomsen, Jeppe Rishede; Saltenis, Simonas

    2009-01-01

    to trade their location privacy for quality of service, limiting the attractiveness of the services. The challenge is to develop a communication-efficient solution such that (i) it detects proximity between a user and the user’s friends, (ii) any other party is not allowed to infer the location of the user...

  5. A two-component signal-transduction cascade in Carnobacterium piscicola LV17B : two signaling peptides and one sensor-transmitter

    NARCIS (Netherlands)

    Kleerebezem, M; Kuipers, OP; de Vos, WM; Stiles, ME; Quadri, LEN; Vos, Willem M. de; Stiles, Michael E.; Quadri, Luis E.N.

    2001-01-01

    In the lactic acid bacterium Carnobacterium piscicola LV17B a peptide-pheromone dependent quorum-sensing mode is involved in the regulation of bacteriocin production. Bacteriocin CB2 was identified as an environmental signal that induces bacteriocin production. Here, we demonstrate that a second 24

  6. Effects of Benzalkonium Chloride, Proxel LV, P3 Hypochloran, Triton X-100 and DOWFAX 63N10 on anaerobic digestion processes

    DEFF Research Database (Denmark)

    Flores, German Antonio Enriquez; Fotidis, Ioannis; Karakashev, Dimitar Borisov

    2015-01-01

    In this study, the individual and synergistic toxicity of the following xenobiotics: Benzalkonium Chloride (BKC), Proxel LV (PRX), P3 Hypochloran (HPC), Triton X-100 (TRX), and DOWFAX 63N10 (DWF), on anaerobic digestion (AD) process, was assessed. The experiments were performed in batch and conti...

  7. A two-component signal-transduction cascade in Carnobacterium piscicola LV17B : two signaling peptides and one sensor-transmitter

    NARCIS (Netherlands)

    Kleerebezem, M; Kuipers, OP; de Vos, WM; Stiles, ME; Quadri, LEN; Vos, Willem M. de; Stiles, Michael E.; Quadri, Luis E.N.

    2001-01-01

    In the lactic acid bacterium Carnobacterium piscicola LV17B a peptide-pheromone dependent quorum-sensing mode is involved in the regulation of bacteriocin production. Bacteriocin CB2 was identified as an environmental signal that induces bacteriocin production. Here, we demonstrate that a second 24

  8. Transspecies Transmission of Gammaretroviruses and the Origin of the Gibbon Ape Leukaemia Virus (GaLV and the Koala Retrovirus (KoRV

    Directory of Open Access Journals (Sweden)

    Joachim Denner

    2016-12-01

    Full Text Available Transspecies transmission of retroviruses is a frequent event, and the human immunodeficiency virus-1 (HIV-1 is a well-known example. The gibbon ape leukaemia virus (GaLV and koala retrovirus (KoRV, two gammaretroviruses, are also the result of a transspecies transmission, however from a still unknown host. Related retroviruses have been found in Southeast Asian mice although the sequence similarity was limited. Viruses with a higher sequence homology were isolated from Melomys burtoni, the Australian and Indonesian grassland melomys. However, only the habitats of the koalas and the grassland melomys in Australia are overlapping, indicating that the melomys virus may not be the precursor of the GaLV. Viruses closely related to GaLV/KoRV were also detected in bats. Therefore, given the fact that the habitats of the gibbons in Thailand and the koalas in Australia are far away, and that bats are able to fly over long distances, the hypothesis that retroviruses of bats are the origin of GaLV and KoRV deserves consideration. Analysis of previous transspecies transmissions of retroviruses may help to evaluate the potential of transmission of related retroviruses in the future, e.g., that of porcine endogenous retroviruses (PERVs during xenotransplantation using pig cells, tissues or organs.

  9. Inadvertent implantation of pacemaker lead in the left ventricle: kill two birds with one stone.

    Science.gov (United States)

    Turk, Ugur Onsel; Tuncer, Esref; Alioglu, Emin; Tengiz, Istemihan; Ercan, Ertugrul

    2014-04-01

    We report an asymptomatic patient in whom the intravenous pacemaker (PM) lead was inadvertently implanted in LV through the perforated interventricular septum. He had no embolic events during the last 9 years after the implantation. Possible explanation of the uncomplicated follow-up period is that the patient had been taking warfarin because of mechanical mitral valve prosthesis.

  10. Mechanical Behaviors and Elastic Parameters of Laminated Fabric URETEK3216LV Subjected to Uniaxial and Biaxial Loading

    Science.gov (United States)

    Chen, Jianwen; Chen, Wujun; Wang, Mingyang; Ding, Yong; Zhou, Han; Zhao, Bing; Fan, Jin

    2017-01-01

    A comprehensive experimental study of the laminated fabric URETEK3216LV subjected to mono-uniaxial, uniaxial cyclic and biaxial cyclic loading was performed to expose the detailed mechanical behaviors and determine proper elastic parameters for the laminated fabrics under specific stress states. The elastic modulus-strain curves and elastic parameter response surfaces were used to reveal the mechanical behaviors, and a weighted average method of integrals was proposed to calculate the elastic parameters for different stress states. Results show that typical stress-strain curves consist of three distinct regions during loading: crimp region, nonlinear transition region and yarn extension region, which is consistent with those of the constitutive yarns. The elastic parameters and mechanical behaviors of the laminated fabric are stress-state specific, and they vary noticeably with the experimental protocols, stress ratios and stress levels. The proposed method is feasible to evaluate the elastic parameters no matter what stress states the materials are subjected to, and thus it may offer potential access to obtain accurate design and analysis of the airship structures under different loading conditions.

  11. Analysis of Maneuvering Targets with Complex Motions by Two-Dimensional Product Modified Lv's Distribution for Quadratic Frequency Modulation Signals.

    Science.gov (United States)

    Jing, Fulong; Jiao, Shuhong; Hou, Changbo; Si, Weijian; Wang, Yu

    2017-06-21

    For targets with complex motion, such as ships fluctuating with oceanic waves and high maneuvering airplanes, azimuth echo signals can be modeled as multicomponent quadratic frequency modulation (QFM) signals after migration compensation and phase adjustment. For the QFM signal model, the chirp rate (CR) and the quadratic chirp rate (QCR) are two important physical quantities, which need to be estimated. For multicomponent QFM signals, the cross terms create a challenge for detection, which needs to be addressed. In this paper, by employing a novel multi-scale parametric symmetric self-correlation function (PSSF) and modified scaled Fourier transform (mSFT), an effective parameter estimation algorithm is proposed-referred to as the Two-Dimensional product modified Lv's distribution (2D-PMLVD)-for QFM signals. The 2D-PMLVD is simple and can be easily implemented by using fast Fourier transform (FFT) and complex multiplication. These measures are analyzed in the paper, including the principle, the cross term, anti-noise performance, and computational complexity. Compared to the other three representative methods, the 2D-PMLVD can achieve better anti-noise performance. The 2D-PMLVD, which is free of searching and has no identifiability problems, is more suitable for multicomponent situations. Through several simulations and analyses, the effectiveness of the proposed estimation algorithm is verified.

  12. Binding of Dumbbell Oligonucleotides to MoMuLV Reverse Transcriptase: Inhibitory Properties of RNase H Activity

    Directory of Open Access Journals (Sweden)

    Ajay Kumar

    2010-01-01

    Full Text Available Dumbbell oligonucleotides with loops of various chemistry were synthesized. Incubation of dumbbell oligonucleotides containing phosphorothioate bonds or trimethylene phosphate linkages in loops with S1 nuclease did not result in significant cleavage under conditions which led to the degradation of dumbbell oligonucleotide containing phophodiester bonds in the loops. The binding of reverse transcriptase of Moloney Murine Leukemia Virus (MoMuLV was evaluated with all the five oligonucleotides. The protein binds to all the dumbbell oligonucleotides with similar affinity. The dissociation constants evaluated using PAGE band mobility shift assays were of the order of 10-7. The inhibitory properties of the retroviral RNase H activity was evaluated using 3H –UTP-labeled RNA:RNA-DNA hybrid. It was found that the best dumbbell oligonucleotide, inhibitor contained phosphorothioate residues in both the loops. Our value studies demonstrated that this particularly designed oligonucleotide displays an IC50 of 18 nM in its inhibition on the reverse transcriptase RNase H activity, a magnitude lower than that of first nucleotide reverse transcriptase of HIV-1, tenofovir, introduced by Gilead Science in the market.

  13. The Effect of Phenazine-1-Carboxylic Acid on Mycelial Growth of Botrytis cinerea Produced by Pseudomonas aeruginosa LV Strain

    Directory of Open Access Journals (Sweden)

    Ane S. Simionato

    2017-06-01

    Full Text Available One of the most important postharvest plant pathogens that affect strawberries, grapes and tomatoes is Botrytis cinerea, known as gray mold. The fungus remains in latent form until spore germination conditions are good, making infection control difficult, causing great losses in the whole production chain. This study aimed to purify and identify phenazine-1-carboxylic acid (PCA produced by the Pseudomonas aeruginosa LV strain and to determine its antifungal activity against B. cinerea. The compounds produced were extracted with dichloromethane and passed through a chromatographic process. The purity level of PCA was determined by reversed-phase high-performance liquid chromatography semi-preparative. The structure of PCA was confirmed by nuclear magnetic resonance and electrospray ionization mass spectrometry. Antifungal activity was determined by the dry paper disk and minimum inhibitory concentration (MIC methods and identified by scanning electron microscopy and confocal microscopy. The results showed that PCA inhibited mycelial growth, where MIC was 25 μg mL-1. Microscopic analysis revealed a reduction in exopolysaccharide (EPS formation, showing distorted and damaged hyphae of B. cinerea. The results suggested that PCA has a high potential in the control of B. cinerea and inhibition of EPS (important virulence factor. This natural compound is a potential alternative to postharvest control of gray mold disease.

  14. Lead Poisoning

    Science.gov (United States)

    ... Topics Environment & Health Healthy Living Pollution Reduce, Reuse, Recycle Science – How It Works The Natural World Games ... OTHERS: Lead has recently been found in some plastic mini-blinds and vertical blinds which were made ...

  15. Molecular characterizations of a novel putative DNA-binding protein LvDBP23 in marine shrimp L. vannamei tissues and molting stages.

    Directory of Open Access Journals (Sweden)

    Yanisa Laoong-u-thai

    Full Text Available BACKGROUND: Litopenaeus Vannamei, well known as pacific white shrimp, is the most popular shrimp in the world shrimp market. Identification and characterization of shrimp muscle regulatory genes are not only important for shrimp genetic improvement, but also facilitate comparative genomic tools for understanding of muscle development and regeneration. METHODOLOGY/PRINCIPAL FINDINGS: A novel mRNA encoding for a putative DNA-binding protein LvDBP23 was identified from Litopenaeus vannamei abdominal muscle cDNA library. The LvDBP23 cDNA contains 639 nucleotides of protein-coding sequence with deduced 212 amino acids of predicted molecular mass 23.32 kDa with glycine-rich domain at amino acid position 94-130. The mRNA sequence is successfully used for producing LvDBP23 recombinant protein in sf9 insect cell expression system. The expression of LvDBP23 mRNA is presented in abdominal muscle and swimming leg muscle, as well as other tissues including intestine, lymphoid and gill. The mRNA expression has the highest level in abdominal muscle in all tested tissues. LVDBP23 transcript during the molt cycle is highly expressed in the intermolt stage. In vitro nucleic acid-binding assays reveal that LvDBP23 protein can bind to both ssDNA and dsDNA, indicating its possible role of regulation of gene transcription. CONCLUSIONS/SIGNIFICANCE: We are the first to report a DNA-binding protein identified from the abdominal muscle tissue of marine shrimp L. Vannamei. Its high-level specific expression during the intermot stage suggests its role in the regulation of muscle buildup during the growth phase of shrimp molt cycle.

  16. Formulation development, optimization and study on drug release kinetics of Eudragit® L100-HPMC E15 LV mixed film-coated colon-targeted Mesalamine tablets

    Directory of Open Access Journals (Sweden)

    A Maria John Newton

    2012-01-01

    Full Text Available The study was designed to evaluate the in vitro dissolution characteristics of pH-sensitive polymer - HPMC E 15 LV-coated tablets - in various simulated fluids (pH range 1.2, 6, 7.2. The Mesalamine tablets were fabricated by mixing the drug with microcrystalline cellulose and other ingredients. The fabricated Mesalamine tablets were coated with Eudragit L100 polymer and HPMC E 15 LV. The fluctuation in colonic pH conditions during inflammatory bowel disease and the nature of less fluid content in the colon may limit the expected drug release in the colon. Addition of HPMC E 15 LV may control this problem by hydrophilic nature and excellent film-forming characteristics like ductility and elasticity. The different batches of Mesalamine tablets (FM1-FM5 were coated with increasing concentration of Eudragit L100 and HPMC E 15 LV. The coating was given up to 8% TWG(Total weight gain of the uncoated tablet. Drug release studies were conducted in different pH conditions in the presence of rat ceaecal contents. The different buffer conditions were chosen to mimic the pH changes in the terminal part of the ileum as well as in the colon. The drug release profile was analyzed for colon-targeting performance in vitro. The release profile of the tablets indicates that the drug release was retarded in the tablet by film coating. The addition of HPMC E 15 LV ensures the channels for allowing colonic fluids to penetrate into the core and subsequent drug release at the target site. The kinetics of the drug release also evaluated the release pattern that was best fitted with Higuchian release. The results of the mechanism of release revealed that drug release was found to be a complex one with diffusion, erosion and swelling.

  17. Locative Inversion in Cantonese.

    Science.gov (United States)

    Mok, Sui-Sang

    This study investigates the phenomenon of "Locative Inversion" in Cantonese. The term "Locative Inversion" indicates that the locative phrase (LP) syntactic process in Cantonese and the appears at the sentence-initial position and its logical subject occurs postverbally. It is demonstrated that this Locative Inversion is a…

  18. Symptoms, syndrome types and therapeutic principles in medical records of diabetes differentiated and treated by Professor LV Ren-he%吕仁和辨治糖尿病医案症状、证候和治则解析

    Institute of Scientific and Technical Information of China (English)

    肖永华; 王世东; 李靖; 高菁; 赵进喜; 吕仁和

    2011-01-01

    . Results The syndrome of dual deficiency of qi and yin might be common in Pidan stage, and occurrence rate of yellow tongue fur was the highest in Xiaoke stage. The syndrome of blood-stasis obstructing collaterals took second in the statistics of syndrome types, which showed that heat syndrome and blood-stasis syndrome were common and important excess syndrome of the tip in Xiaoke stage. Liver-kidney yin deficiency syndrome and qi-yin deficiency syndrome were common deficient syndrome of the root in Xiaoke stage. Spleen-kidney yang deficiency syndrome summarized by Professor LV Ren-hewas relatively rare in the past. The statistics of symptoms and signs in Xiaodan stage showed that syndrome of dual deficiency of liver and kidney was obvious in this stage. Dampness-heat, phlegm-fluid and blood stasis were common in Xiaodan stage and they cemented together to lead to turbidity-toxin. The statistics of syndromes showed that the syndrome of blood-stasis obstructing collaterals came first in Xiaodan stage. It indicated that the frequency of the syndrome of blood-stasis obstructing collaterals increased significantly with the development of disease course compared with the statistic results of other two stages, which corresponded with Professor LV Ren-he's hypothesis of microscopic aggregation-accumulation. The statistic results of therapeutic principles were consistent with the syndrome features in this stage recognized by Professor LV Ren-he, I. E. Deficiency of qi, blood, yin and yang and internal retention of turbidity-toxin. Conclusion The analysis of symptoms, signs, syndromes and therapeutic principles in three stages of diabetes had a higher internal goodness of fit, and accorded with Professor LV Ren-he's theory of differentiation and treatment of diabetes at stages.

  19. Ecotoxicology: Lead

    Science.gov (United States)

    Scheuhammer, A.M.; Beyer, W.N.; Schmitt, C.J.; Jorgensen, Sven Erik; Fath, Brian D.

    2008-01-01

    Lead (Pb) is a naturally occurring metallic element; trace concentrations are found in all environmental media and in all living things. However, certain human activities, especially base metal mining and smelting; combustion of leaded gasoline; the use of Pb in hunting, target shooting, and recreational angling; the use of Pb-based paints; and the uncontrolled disposal of Pb-containing products such as old vehicle batteries and electronic devices have resulted in increased environmental levels of Pb, and have created risks for Pb exposure and toxicity in invertebrates, fish, and wildlife in some ecosystems.

  20. Efectos combinados de la vitamina c y e dietéticas en la inmunorespuest del juvenil lv antes y después de la suplementación con glucanos

    OpenAIRE

    Molina, César; Rodríguez, Jenny; Arango, José Ignacio; Echeverría, Fabrizio; Sotomayor, Mariuxi

    2002-01-01

    Efectos combinados de la vitamina C y E dietéticas en la inmunorespuest del juvenil LV antes y después de la suplementación con glucanos Efectos combinados de la vitamina C y E dietéticas en la inmunorespuest del juvenil LV antes y después de la suplementación con glucanos

  1. Astakine LvAST binds to the β subunit of F1-ATP synthase and likely plays a role in white shrimp Litopeneaus vannamei defense against white spot syndrome virus.

    Science.gov (United States)

    Liang, Gao-Feng; Liang, Yan; Xue, Qinggang; Lu, Jin-Feng; Cheng, Jun-Jun; Huang, Jie

    2015-03-01

    Cytokines play a critical role in innate and adaptive immunity. Astakines represent a group of invertebrate cytokines that are related to vertebrate prokineticin and function in promoting hematopoiesis in crustaceans. We have identified an astakine from the white shrimp Litopeneaus vannamei and named it LvAST in a previous research. In the present research, we investigated the interactions among LvAST, the envelope protein VP37 of white spot syndrome virus (i.e., WSSV), and the β subunit of F1-ATP synthase (ATPsyn-β) of the white shrimp (i.e., BP53) using binding assays and co-precipitations. We also examined the effects of LvAST on shrimp susceptibility to WSSV. We found that LvAST and VP37 competitively bound to BP53, but did not bind to each other. Shrimps that had been injected with recombinant LvAST exhibited significantly lower mortality and longer survival time in experimental infections by WSSV. In contrast, shrimps whose LvAST gene expression had been inhibited by RNA interference showed significantly higher WSSV infection intensity and shorter survival time following viral challenges. These results suggested that LvAST and WSSV both likely use ATPsyn-β as a receptor and LvAST plays a role in shrimp defense against WSSV infection. This represented the first research showing the involvement of astakines in host antiviral immunity.

  2. A phase II experience with neoadjuvant irinotecan (CPT-11, 5-fluorouracil (5-FU and leucovorin (LV for colorectal liver metastases

    Directory of Open Access Journals (Sweden)

    Bigam David

    2009-05-01

    Full Text Available Abstract Background Chemotherapy may improve survival in patients undergoing resection of colorectal liver metastases (CLM. Neoadjuvant chemotherapy may help identify patients with occult extrahepatic disease (averting unnecessary metastasectomy, and it provides in vivo chemosensitivity data. Methods A phase II trial was initiated in which patients with resectable CLM received CPT-11, 5-FU and LV for 12 weeks. Metastasectomy was performed unless extrahepatic disease appeared. Postoperatively, patients with stable or responsive disease received the same regimen for 12 weeks. Patients with progressive disease received either second-line chemotherapy or best supportive care. The primary endpoint was disease-free survival (DFS; secondary endpoints included overall survival (OS and safety. Results 35 patients were accrued. During preoperative chemotherapy, 16 patients (46% had grade 3/4 toxicities. Resection was not possible in 5 patients. One patient died of arrhythmia following surgery, and 1 patient had transient liver failure. During the postoperative treatment phase, 12 patients (55% had grade 3/4 toxicities. Deep venous thrombosis (DVT occurred in 11 patients (34% at various times during treatment. Of those who underwent resection, median DFS was 23.0 mo. and median OS has not been reached. The overall survival from time of diagnosis of liver metastases was 51.6 mo for the entire cohort. Conclusion A short course of chemotherapy prior to hepatic metastasectomy may serve to select candidates best suited for resection and it may also direct postoperative systemic treatment. Given the significant incidence of DVT, alternative systemic neoadjuvant regimens should be investigated, particularly those that avoid the use of a central venous line. Trial Registration ClinicalTrials.gov NCT00168155.

  3. 2D longitudinal LV speckle tracking strain pattern in breast cancer survivors: sports activity vs exercise as prescription model.

    Science.gov (United States)

    Galanti, Giorgio; Pedrizzetti, Gianni; Pedri, Stefano; Stefani, Laura

    2017-09-05

    Prevention strategies are important to optimize and to manage heart care in breast cancer survivors. Regular physical activity at moderate intensity is normally proposed to maintain myocardial performance; however, no data is available about the different impact of different levels of physical exercise. 2D speckle tracking echocardiography (2DSTE) is an accepted method for early detection of myocardial dysfunction. The study aims to monitor the cardiac performances in breast cancer survivors by 2DSTE analysis to manage sports activity vs physical activity. Two groups of previous breast cancer survivors (33 BCS) trained at moderate intensity and 55 athletes practicing dragon boat (DBA) sport were enrolled. They were matched with two healthy subjects groups: 23 competitive female athletes practicing different sports and 20 healthy women trained with exercise as prescription model. All women were studied by a complete echo examination including LV global longitudinal strain (GLS) assessment (XStrain-Esaote). EF and GS are only significantly higher in healthy subjects (-25.4 ± 2.1). Nevertheless, GLS values are within the normal range for all groups. Particularly, GS does not show any significant differences among subjects (-19.93 ± 4) practicing exercise as prescription when compared to the DBA competitive trained group. 2DSTE method is an appropriate method to supervise the intensity of exercise in breast cancer patients. Particularly, GLS can optimize and improve cancer therapy supporting and creating efficiencies within the health system confirming the role of the exercise prescription therapy in maintaining normal heart function.

  4. Leading men

    DEFF Research Database (Denmark)

    Bekker-Nielsen, Tønnes

    2016-01-01

    Through a systematic comparison of c. 50 careers leading to the koinarchate or high priesthood of Asia, Bithynia, Galatia, Lycia, Macedonia and coastal Pontus, as described in funeral or honorary inscriptions of individual koinarchs, it is possible to identify common denominators but also...

  5. Lead grids

    CERN Multimedia

    1974-01-01

    One of the 150 lead grids used in the multiwire proportional chamber g-ray detector. The 0.75 mm diameter holes are spaced 1 mm centre to centre. The grids were made by chemical cutting techniques in the Godet Workshop of the SB Physics.

  6. Law Enforcement Locations

    Data.gov (United States)

    Kansas Data Access and Support Center — Law Enforcement Locations in Kansas Any location where sworn officers of a law enforcement agency are regularly based or stationed. Law enforcement agencies "are...

  7. Onderzoek location based marketing: Mobile = location = effect

    NARCIS (Netherlands)

    Gisbergen, M.S. van; Huhn, A.E.; Khan, V.J.; Ketelaar, P.E.

    2011-01-01

    Onderzoekers van de NHTV (Internationaa Hoger Onderwijs Breda, Radboud Universiteit, DVJ Insights en Popai Benelux lieten consumenten in een virtuele supermarkt advertenties via de smartphone ontvangen wanneer men langs het geadverteerde product liep. De uitkomsten laten zien dat 'location based adv

  8. Onderzoek location based marketing: Mobile = location = effect

    OpenAIRE

    Gisbergen, M.S. van; Huhn, A.E.; Khan, V.J.; Ketelaar, P.E.

    2011-01-01

    Onderzoekers van de NHTV (Internationaa Hoger Onderwijs Breda, Radboud Universiteit, DVJ Insights en Popai Benelux lieten consumenten in een virtuele supermarkt advertenties via de smartphone ontvangen wanneer men langs het geadverteerde product liep. De uitkomsten laten zien dat 'location based advertising' effectief is.

  9. Locatives in Kpelle.

    Science.gov (United States)

    Kuha, Mai

    This paper examines the differences between locative expressions in Kpelle and English, based on the dialect of one native speaker of Kpelle. It discusses the crucial role of the reference object in defining the meaning of locatives in Kpelle, in contrast to English, where the characteristics of the object to be located are less important. An…

  10. Who Leads China's Leading Universities?

    Science.gov (United States)

    Huang, Futao

    2017-01-01

    This study attempts to identify the major characteristics of two different groups of institutional leaders in China's leading universities. The study begins with a review of relevant literature and theory. Then, there is a brief introduction to the selection of party secretaries, deputy secretaries, presidents and vice presidents in leading…

  11. 浅谈吕叔湘的作文教学观%A Brief Discussion on Lv Shuxiang's Teaching Idea of Writing

    Institute of Scientific and Technical Information of China (English)

    郑礼立

    2012-01-01

    Writing teaching is a most important link in Chinese teaching,so many Chinese educators have deeply studied on writing teaching,including Lv Shuxiang.This paper summarizes and introduces Mr.Lv's teaching idea of writing from four aspects:title of a composition,teaching methods of writing,requirements of writing and writing assessment.%作文教学是语文教学中最重要的环节之一,许多语文学家都对此进行了深入的研究,吕叔湘先生也不例外。这篇文章主要从作文题目、作文教学方法、作文要求、作文评改等四个方面对吕老的作文观点进行了整合与介绍。

  12. Noise Source Location Optimization

    Directory of Open Access Journals (Sweden)

    Ed O’Keefe

    1994-01-01

    Full Text Available This article describes a method to determine locations of noise sources that minimize modal coupling in complex acoustic volumes. Using the acoustic source scattering capabilities of the boundary element method, predictions are made of mode shape and pressure levels due to various source locations. Combining knowledge of the pressure field with a multivariable function minimization technique, the source location generating minimum pressure levels can be determined. The analysis also allows for an objective comparison of “best/worst” locations. The technique was implemented on a personal computer for the U.S. Space Station, predicting 5–10 dB noise reduction using optimum source locations.

  13. Smartphones as locative media

    CERN Document Server

    Frith, Jordan

    2015-01-01

    Smartphone adoption has surpassed 50% of the population in more than 15 countries, and there are now more than one million mobile applications people can download to their phones. Many of these applications take advantage of smartphones as locative media, which is what allows smartphones to be located in physical space. Applications that take advantage of people's location are called location-based services, and they are the focus of this book. Smartphones as locative media raise important questions about how we understand the complicated relationship between the Internet and physical space

  14. Molecular Characterizations of a Novel Putative DNA-Binding Protein LvDBP23 in Marine Shrimp L. vannamei Tissues and Molting Stages

    OpenAIRE

    Yanisa Laoong-u-thai; Baoping Zhao; Amornrat Phongdara; Jinzeng Yang

    2011-01-01

    BACKGROUND: Litopenaeus Vannamei, well known as pacific white shrimp, is the most popular shrimp in the world shrimp market. Identification and characterization of shrimp muscle regulatory genes are not only important for shrimp genetic improvement, but also facilitate comparative genomic tools for understanding of muscle development and regeneration. METHODOLOGY/PRINCIPAL FINDINGS: A novel mRNA encoding for a putative DNA-binding protein LvDBP23 was identified from Litopenaeus vannamei abdom...

  15. A prospective randomized study of irinotecan (CPT-11), leucovorin (LV) and 5-fluorouracil (5FU) versus leucovorin and 5-fluorouracil in patients with advanced colorectal carcinoma.

    Science.gov (United States)

    Gennatas, C; Papaxoinis, G; Michalaki, V; Mouratidou, D; Andreadis, C; Tsavaris, N; Pafiti, A

    2006-10-01

    The purpose of this study was to compare the activity and toxicity of an irinotecan (CPT-11), leucovorin (LV) and 5-fluorouracil (5FU) combination with a standard regimen of 5FU and LV, in patients with advanced colorectal carcinoma. One hundred and sixty patients were randomized; 80 patients (group A) received LV 20 mg/m(2) bolus i.v. and 5FU 425 mg/m(2) bolus i.v. on days 1-5, every 28 days; 80 patients (group B) received CPT-11 80 mg/m(2) (30-90 min i.v. infusion), followed by LV 20 mg/m(2) bolus i.v. and 5FU 425 mg/m(2) bolus i.v. on days 1, 8, 15, 22, 29, and 36, every 8 weeks. The overall response rate was 30% and 47.5% in groups A and B respectively. Progression-free survival was significantly higher in the triple-drug combination arm (median 7.5 vs. 4.5 months; p= 0. 0335). However, overall survival did not differ significantly between the two arms (15 months vs. 14 months for the groups B and A respectively; p=0.3531). The main grade 3 adverse events were diarrhea (19%, in group A vs. 35% in group B; p=0.032) and mucositis (2% vs. 14%; p=0.017). The regimen containing irinotecan showed activity in advanced colorectal cancer. The overall safety data confirm this combination as a well-tolerated treatment.

  16. Handelsgødnings indflydelse på afgrøders indhold af arsen, bly, cadmium, krom, kviksølv og nikkel

    DEFF Research Database (Denmark)

    Christensen, Bent Tolstrup; Elsgaard, Lars

    Denne rapport belyser indholdet af arsen (As), bly (Pb), cadmium (Cd), krom (Cr), kviksølv (Hg) og nikkel (Ni) i afgrøder, der er dyrket ved forskellige niveauer af handelsgødning (fra ugødet til to gange normal gødskning). Effekten af handelsgødning er sammenlignet med effekten af husdyrgødning...

  17. Assessment of Longitudinal Reproducibility of Mice LV Function Parameters at 11.7 T Derived from Self-Gated CINE MRI

    Science.gov (United States)

    Zuo, Zhi; Subgang, Anne; Abaei, Alireza; Rottbauer, Wolfgang; Stiller, Detlef; Ma, Genshan

    2017-01-01

    The objective of this work was the assessment of the reproducibility of self-gated cardiac MRI in mice at ultra-high-field strength. A group of adult mice (n = 5) was followed over 360 days with a standardized MR protocol including reproducible animal position and standardized planning of the scan planes. From the resulting CINE MRI data, global left ventricular (LV) function parameters including end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), and left ventricular mass (LVM) were quantified. The reproducibility of the self-gated technique as well as the intragroup variability and longitudinal changes of the investigated parameters was assessed. Self-gated cardiac MRI proved excellent reproducibility of the global LV function parameters, which was in the order of the intragroup variability. Longitudinal assessment did not reveal any significant variations for EDV, ESV, SV, and EF but an expected increase of the LVM with increasing age. In summary, self-gated MRI in combination with a standardized protocol for animal positioning and scan plane planning ensures reproducible assessment of global LV function parameters. PMID:28321415

  18. Assessment of Longitudinal Reproducibility of Mice LV Function Parameters at 11.7 T Derived from Self-Gated CINE MRI.

    Science.gov (United States)

    Zuo, Zhi; Subgang, Anne; Abaei, Alireza; Rottbauer, Wolfgang; Stiller, Detlef; Ma, Genshan; Rasche, Volker

    2017-01-01

    The objective of this work was the assessment of the reproducibility of self-gated cardiac MRI in mice at ultra-high-field strength. A group of adult mice (n = 5) was followed over 360 days with a standardized MR protocol including reproducible animal position and standardized planning of the scan planes. From the resulting CINE MRI data, global left ventricular (LV) function parameters including end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), and left ventricular mass (LVM) were quantified. The reproducibility of the self-gated technique as well as the intragroup variability and longitudinal changes of the investigated parameters was assessed. Self-gated cardiac MRI proved excellent reproducibility of the global LV function parameters, which was in the order of the intragroup variability. Longitudinal assessment did not reveal any significant variations for EDV, ESV, SV, and EF but an expected increase of the LVM with increasing age. In summary, self-gated MRI in combination with a standardized protocol for animal positioning and scan plane planning ensures reproducible assessment of global LV function parameters.

  19. Leading Cities

    DEFF Research Database (Denmark)

    Pogner, Karl-Heinz

    2017-01-01

    and technical engineering; Smart Cities) is very prominent in the traditional mass media discourse, in PR / PA of tech companies and traditional municipal administrations; whereas the second one (participation; Livable Cities) is mostly enacted in social media, (local) initiatives, movements, (virtual......) communities, new forms of urban governance in municipal administration and co-competitive city networks. Both forms seem to struggle for getting voice and power in the discourses, negotiations, struggles, and conflicts in Urban Governance about the question how to manage or lead (in) a city. Talking about...

  20. Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction.

    Science.gov (United States)

    Tang, Yi-Da; Kuzman, James A; Said, Suleman; Anderson, Brent E; Wang, Xuejun; Gerdes, A Martin

    2005-11-15

    Although thyroid dysfunction has been linked to heart failure, it is not clear whether hypothyroidism alone can cause heart failure. Hypothyroidism was induced in adult rats by treatment with 0.025% propylthiouracil (PTU) for 6 weeks (PTU-S) and 1 year (PTU-L). Echocardiographic measurements, left ventricular (LV) hemodynamics, isolated myocyte length (KOH method), myocardial blood flow (fluorescent microspheres), arteriolar morphometry, and gene expression (Western blot) were determined. Heart weight, heart rate, LV systolic blood pressure, LV ejection fraction, LV fractional shortening, and systolic wall thickness were reduced in PTU-S and PTU-L rats. LV internal diameter in systole increased by 40% in PTU-S and 86% in PTU-L. LV internal dimension in diastole was increased in PTU-S and PTU-L rats, but only PTU-L rats showed a significant increase in myocyte length due to series sarcomere addition. Resting and maximum (adenosine) myocardial blood flow were reduced in both PTU-S and PTU-L rats. Impaired blood flow was due to a large reduction in arteriolar length density and small arterioles in PTU-S and PTU-L (Pcardiac mass. Chamber dilatation in PTU-L rats was due to series sarcomere addition, typical of heart failure. Hypothyroidism resulted in impaired myocardial blood flow due to a dramatic loss of arterioles. Thus, we have identified 2 important new mechanisms by which low thyroid function may lead to heart failure.

  1. A SURVEY ON LEAD INTOXICATION IN LEAD MINERS

    Directory of Open Access Journals (Sweden)

    P. Meshgi

    1972-12-01

    Full Text Available A survey on lead intoxication in lead mine workers was carried out among Khanehsorme, lead miners in NajafAabad and also in Ab-bagh lead miners in Shahreza, both located in district of Esfahan, Iran. The studies were carried out on 62 miners out of 82 employees in Khanehsorme, 25 miners out of 27 employees in Ab-bagh lead miners and 47 rural inhabitants in the surroundings of mines were selected as the Control group. Clinical examinations were done. Age and sex group, working hours, type of work, and duration of service and previous occupation of workers were questioned. The determination of lead in urine was done according to Truhaut et Boudene's method and the content of blood Hemoglobin was performed according to Sali method. Results obtained in lead miners in comparison with the control group showed the absorption of lead and consequently lead intoxication was observed some extent.

  2. Location Privacy Techniques in Client-Server Architectures

    Science.gov (United States)

    Jensen, Christian S.; Lu, Hua; Yiu, Man Lung

    A typical location-based service returns nearby points of interest in response to a user location. As such services are becoming increasingly available and popular, location privacy emerges as an important issue. In a system that does not offer location privacy, users must disclose their exact locations in order to receive the desired services. We view location privacy as an enabling technology that may lead to increased use of location-based services.

  3. First-in-Human Treatment With a Dendritic Cell-targeting Lentiviral Vector-expressing NY-ESO-1, LV305, Induces Deep, Durable Response in Refractory Metastatic Synovial Sarcoma Patient.

    Science.gov (United States)

    Pollack, Seth M; Lu, Hailing; Gnjatic, Sacha; Somaiah, Neeta; O'Malley, Ryan B; Jones, Robin L; Hsu, Frank J; Ter Meulen, Jan

    2017-10-01

    Effective induction of antitumor T cells is a pivotal goal of cancer immunotherapy. To this end, lentiviral vectors (LV) are uniquely poised to directly prime CD8 T-cell responses via transduction of dendritic cells in vivo and have shown promise as active cancer therapeutics in preclinical tumor models. However, until now, significant barriers related to production and regulation have prevented their widespread use in the clinic. We developed LV305, a dendritic cell-targeting, integration-deficient, replication incompetent LV from the ZVex platform, encoding the full-length cancer-testis antigen NY-ESO-1. LV305 is currently being evaluated in phase 1 and 2 trials in metastatic recurrent cancer patients with NY-ESO-1 positive solid tumors as a single agent and in combination with anti-PD-L1. Here we report on the first patient treated with LV305, a young woman with metastatic, recurrent, therapy-refractive NY-ESO-1 synovial sarcoma. The patient developed a robust NY-ESO-1-specific CD4 and CD8 T-cell response after 3 intradermal injections with LV305, and subsequently over 85% disease regression that is continuing for >2.5 years posttherapy. No adverse events >grade 2 occurred. This case demonstrates that LV305 can be safely administered and has the potential to induce a significant clinical benefit and immunologic response in a patient with advanced stage cancer.

  4. Generic Network Location Service

    Directory of Open Access Journals (Sweden)

    Laban Mwansa

    2010-11-01

    Full Text Available This work presents the Generic Network Location Service based on the Chord implementation utilizing data structures called distributed hash tables (DHT or structured overlay networks, which are used to build scalable self-managing distributed systems. The provided algorithms guarantee resilience in the presence of dynamism: they guarantee consistent lookup results in the presence of nodes failing and leaving. Generic Network Location Service provides a Location Service system based on DHT technology, which is storing device location records in nodes within a Chord DHT. Location records are consisting of network device identification keys as attributes, which are used to create replicas of additional location records through established Chord hashing mechanisms. Storing device location records, in places address-able (using the DHT lookup by individual location record keys provides a simple way of implementing transla¬tion functions similar to well¬ known network services (e.g. ARP, DNS, ENUM. The generic network location ser¬vice presented in the paper is not supposed to be a substitu¬tion of the existing translation techniques (e.g. ARP, DNS, ENUM, but it is considered as an overlay service that uses data available in existing systems and provides some translations currently unavailable.

  5. Smart Location Database - Download

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Smart Location Database (SLD) summarizes over 80 demographic, built environment, transit service, and destination accessibility attributes for every census block...

  6. Smart Location Database - Service

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Smart Location Database (SLD) summarizes over 80 demographic, built environment, transit service, and destination accessibility attributes for every census block...

  7. HeLv – Helpdesk für Lehrer/innen verhaltensauffälliger Schüler/innen - eine netzbasierte Serviceplattform für Lehrer/innen

    Directory of Open Access Journals (Sweden)

    Stefan Germany

    2012-10-01

    Full Text Available The article presents the serviceplatform HeLv-Helpdesk for teachers for pupils with conduct disorder (http://helv.ph-noe.ac.at. HeLv offers easy access to its monitoring and coaching platform as well as a FAQ, contacts for networking with local institutions and a big offer of specialist literature. The focus of the article is on the genese of the service, actual developments and future work which will concentrate on better dissemination and awareness for the support being given by HeLv.

  8. Industrial location and competitiveness

    NARCIS (Netherlands)

    S. Brakman (Steven); J.H. Garretsen (Harry); J.G.M. van Marrewijk (Charles)

    2006-01-01

    textabstractThe interaction between the extent of location advantages and the intensity of firm competition relative to the size of the market jointly determines the location of industrial activity. Technology, factor endowments, geography, and scale economies are influential for determining locatio

  9. Appraising manufacturing location

    NARCIS (Netherlands)

    Steenhuis, Harm-Jan; Bruijn, de Erik J.

    2002-01-01

    International location of manufacturing activities is an issue for managers of manufacturing companies as well as public policy makers. For managers, the issue is relevant because international locations offer opportunities for lowering costs due to productivity improvements. For governments the iss

  10. Assessing manufacturing location

    NARCIS (Netherlands)

    Steenhuis, Harm-Jan; Bruijn, de Erik J.

    2004-01-01

    International location of manufacturing activities is an issue for managers of manufacturing companies as well as public policy-makers. For managers, the issue is relevant because international locations offer opportunities for lowering costs due to productivity improvements. For governments the iss

  11. Study of semi-leptonic decay of B meson, in the ways lvD{sup *} and lvD with ALEPH detector at LEP: measurement of the fragmentation function of b quark and search for D{sup **} states; Etude des desintegrations semi-leptoniques du meson B, dans les canaux D*lv et Dlv, aupres du detecteur ALEPH au LEP: mesure de la fonction de fragmentation du quark b et recherche d`etats D**

    Energy Technology Data Exchange (ETDEWEB)

    Bonis, I. de

    1994-06-01

    This work is dedicated to the measurement of the fragmentation function of the quark b, with the ALEPH detector, at LEP. The main aspects of this measure is to be as independent as possible from any model. For this, we reconstruct the semi-leptonic decay modes of the B meson, in the ways lvD deg., lvD{sup *+} and lvD{sup +}. In a first step, we describe the criteria used to select those modes. Then, we determine the fragmentation function by measuring the ratio X{sub B} = 2 E{sub B} / {radical} S, where E{sub B} is the B meson energy and {radical} s/2 the useful energy in the center of mass. The measure of E{sub B} needs a precise reconstruction of the neutrino energy, which is not detected. We present here the method that we used for this reconstruction. Once the acceptance correction is applied, we obtain, for the variable X{sub B}, a distribution with mean value: < X{sub B} > = 0.711 {+-} 0.009 (stat). To be as independent as possible of the model (Peterson function) used n the Monte-Carlo determination of the acceptance, we do an iterative calculation of the acceptance. We obtain < X{sub B}> = 0.712 {+-} 0.009(stat) {+-} 0.017 (syst). Furthermore, this measure depends of the D** contribution, badly known for now. Therefore, we search this contribution, using the events selected before, on the one hand by a direct observation, on the other hand by reconstructing the mass of the B meson. (author). 64 refs.

  12. WHO Standard Acupuncture Point Locations

    Directory of Open Access Journals (Sweden)

    Sabina Lim

    2010-01-01

    Full Text Available ‘WHO Standard Acupuncture Point Locations in the Western Pacific Region (WHO Standard was released in 2008. Initially, there were 92/361 controversial acupuncture points (acupoints. Through seven informal consultations and four task force team meetings, 86 points were agreed upon among the 92 controversial acupoints, leaving 6 remaining controversial acupoints, demanding active research in the future. This will enhance the reproducibility and validity of acupuncture studies. It will also lead to a better understanding of acupuncture mechanisms in order to optimize its clinical efficacy for a range of diseases and syndromes. This book has two parts: General Guidelines for Acupuncture Point Locations and WHO Standard Acupuncture Point Locations. First of all, familiarity with the General Guidelines for Acupuncture Point Locations in this book can help the reader to understand and use the contents of this book in depth. I would like to thank all of the participating experts and scholars for this great work, who have overcome the limits of previous acupuncture references. I also appreciate the dedicated effort and harmonious leadership of Dr Choi Seung-hoon, former Regional Adviser in Traditional Medicine of Western Pacific Office, WHO.

  13. Smart Location Mapping

    Science.gov (United States)

    The Smart Location Database, Access to Jobs and Workers via Transit, and National Walkability Index tools can help assess indicators related to the built environment, transit accessibility, and walkability.

  14. Waste Recovery Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Locations where City residents are encouraged to drop off and dispose or recycle of unwanted materials. Information provided is subject to change. Please call ahead...

  15. Electronic apex locators.

    Science.gov (United States)

    Gordon, M P J; Chandler, N P

    2004-07-01

    Prior to root canal treatment at least one undistorted radiograph is required to assess canal morphology. The apical extent of instrumentation and the final root filling have a role in treatment success, and are primarily determined radiographically. Electronic apex locators reduce the number of radiographs required and assist where radiographic methods create difficulty. They may also indicate cases where the apical foramen is some distance from the radiographic apex. Other roles include the detection of root canal perforation. A review of the literature focussed first on the subject of electronic apex location. A second review used the names of apex location devices. From the combined searches, 113 pertinent articles in English were found. This paper reviews the development, action, use and types of electronic apex locators.

  16. Allegheny County Dam Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset shows the point locations of dams in Allegheny County. If viewing this description on the Western Pennsylvania Regional Data Center’s open data portal...

  17. VT Hospital Site Locations

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) This data layer contains point locations of all major community, regional, comprehensive health, and healthcare provider hospitals in the state of...

  18. IHS Facility Locator

    Data.gov (United States)

    U.S. Department of Health & Human Services — This map can be used to find an Indian Health Service, Tribal or Urban Indian Health Program facility. This map can be used to: Zoom in to a general location to...

  19. USAID Activity Locations

    Data.gov (United States)

    US Agency for International Development — The USAID Activities dataset is a snapshot of activities supported by USAID including their geographical locations within countries at the time of the snapshot. The...

  20. Eldercare Locator Database

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Eldercare Locator is a searchable database that allows a user to search via zip code or city/ state for agencies at the State and local levels that provide...

  1. Uranium Location Database

    Data.gov (United States)

    U.S. Environmental Protection Agency — A GIS compiled locational database in Microsoft Access of ~15,000 mines with uranium occurrence or production, primarily in the western United States. The metadata...

  2. Global Volcano Locations Database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NGDC maintains a database of over 1,500 volcano locations obtained from the Smithsonian Institution Global Volcanism Program, Volcanoes of the World publication. The...

  3. Chemical abundances in the protoplanetary disc LV 2 (Orion): clues to the causes of the abundance anomaly in H II regions

    Science.gov (United States)

    Tsamis, Y. G.; Walsh, J. R.; Vílchez, J. M.; Péquignot, D.

    2011-04-01

    Optical integral field spectroscopy of the archetype protoplanetary disc LV 2 in the Orion nebula is presented, taken with the Very Large Telescope (VLT) FLAMES/Argus fibre array. The detection of recombination lines (RLs) of C II and O II from this class of objects is reported, and the lines are utilized as abundance diagnostics. The study is complemented with the analysis of Hubble Space Telescope (HST) Faint Object Spectrograph ultraviolet and optical spectra of the target contained within the Argus field of view. By subtracting the local nebula background the intrinsic spectrum of the proplyd is obtained and its elemental composition is derived for the first time. The proplyd is found to be overabundant in carbon, oxygen and neon compared to the Orion nebula and the Sun. The simultaneous coverage over LV 2 of the C III]λ1908 and [O III]λ5007 collisionally excited lines (CELs) and C II and O II RLs has enabled us to measure the abundances of C2 + and O2 + for LV 2 with both sets of lines. The two methods yield consistent results for the intrinsic proplyd spectrum, but not for the proplyd spectrum contaminated by the generic nebula spectrum, thus providing one example where the long-standing abundance anomaly plaguing metallicity studies of H II regions has been resolved. These results would indicate that the standard forbidden-line methods used in the derivation of light metal abundances in H II regions in our own and other galaxies underestimate the true gas metallicity.

  4. Location and logistics

    OpenAIRE

    Alumura, Sibel A.; Karab, Bahar Y.; Melo, M. Teresa

    2013-01-01

    Facility location decisions play a critical role in designing logistics networks. This article provides some guidelines on how location decisions and logistics functions can be integrated into a single mathematical model to optimize the configuration of a logistics network. This will be illustrated by two generic models, one supporting the design of a forward logistics network and the other addressing the specific requirements of a reverse logistics network. Several special cases and extensio...

  5. Location and logistics

    OpenAIRE

    Alumura, Sibel A.; Karab, Bahar Y.; Melo, M. Teresa

    2013-01-01

    Facility location decisions play a critical role in designing logistics networks. This article provides some guidelines on how location decisions and logistics functions can be integrated into a single mathematical model to optimize the configuration of a logistics network. This will be illustrated by two generic models, one supporting the design of a forward logistics network and the other addressing the specific requirements of a reverse logistics network. Several special cases and extensio...

  6. DC-link Voltage Control to Compensate Voltage Deviation for PV–BESSs Integrated System in Low-Voltage (LV Networks

    Directory of Open Access Journals (Sweden)

    Lee Gyu-sub

    2016-01-01

    Full Text Available The exhaustion of fossil fuel and the greenhouse gas emission are one of the most significant energy and environmental issues, respectively. Photovoltaic (PV generators and battery energy storage systems (BESSs have been significantly increased for recent years. The BESSs are mainly used for smoothing active power fluctuation of the PV. In this paper, PV–BESSs integration of two DC/DC converters and one AC/DC converter is investigated and DC-link voltage control to compensate the AC voltage deviation is proposed for the PV‒BESS system in low-voltage (LV networks.

  7. Magnesium Diboride Current Leads

    Science.gov (United States)

    Panek, John

    2010-01-01

    A recently discovered superconductor, magnesium diboride (MgB2), can be used to fabricate conducting leads used in cryogenic applications. Dis covered to be superconducting in 2001, MgB2 has the advantage of remaining superconducting at higher temperatures than the previously used material, NbTi. The purpose of these leads is to provide 2 A of electricity to motors located in a 1.3 K environment. The providing environment is a relatively warm 17 K. Requirements for these leads are to survive temperature fluctuations in the 5 K and 11 K heat sinks, and not conduct excessive heat into the 1.3 K environment. Test data showed that each lead in the assembly could conduct 5 A at 4 K, which, when scaled to 17 K, still provided more than the required 2 A. The lead assembly consists of 12 steelclad MgB2 wires, a tensioned Kevlar support, a thermal heat sink interface at 4 K, and base plates. The wires are soldered to heavy copper leads at the 17 K end, and to thin copper-clad NbTi leads at the 1.3 K end. The leads were designed, fabricated, and tested at the Forschungszentrum Karlsruhe - Institut foer Technische Physik before inclusion in Goddard's XRS (X-Ray Spectrometer) instrument onboard the Astro-E2 spacecraft. A key factor is that MgB2 remains superconducting up to 30 K, which means that it does not introduce joule heating as a resistive wire would. Because the required temperature ranges are 1.3-17 K, this provides a large margin of safety. Previous designs lost superconductivity at around 8 K. The disadvantage to MgB2 is that it is a brittle ceramic, and making thin wires from it is challenging. The solution was to encase the leads in thin steel tubes for strength. Previous designs were so brittle as to risk instrument survival. MgB2 leads can be used in any cryogenic application where small currents need to be conducted at below 30 K. Because previous designs would superconduct only at up to 8 K, this new design would be ideal for the 8-30 K range.

  8. Geostar - Navigation location system

    Science.gov (United States)

    Keyser, Donald A.

    The author describes the Radiodetermination Satellite Service (RDSS). The initial phase of the RDSS provides for a unique service enabling central offices and headquarters to obtain position-location information and receive short digital messages from mobile user terminals throughout the contiguous United States, southern Canada, and northern Mexico. The system employs a spread-spectrum, CDMA modulation technique allowing multiple customers to use the system simultaneously, without preassigned coordination with fellow users. Position location is currently determined by employing an existing radio determination receiver, such as Loran-C, GPS, or Transit, in the mobile user terminal. In the early 1990s position location will be determined at a central earth station by time-differential ranging of the user terminals via two or more geostationary satellites. A brief overview of the RDSS system architecture is presented with emphasis on the user terminal and its diverse applications.

  9. 论吕碧城护生思想的产生原因%Reasons for LV Bicheng’ s Protecting Animals Thought

    Institute of Scientific and Technical Information of China (English)

    耿春晓

    2014-01-01

    At her early ages ,LV Bicheng advocated feminist movement and female educa-tion,while she devoted more to animal protecting activities at her middle age .There were pro-found thoughts for her choosing different life course ,including religion ,peace and civilization . The environment at that time ,domestically and abroad ,was also decisive .LV Bicheng made this decision with years of consideration .As a Buddhist ,it was her way of saving the chaotic society .%晚清著名女词人吕碧城早年致力于女权运动和兴办女学,中年后却致力于护生,从事动物保护运动。她之所以选择与早年不同的人生轨迹,其实包含了许多对于宗教、和平与文明的深刻思考,与当时的国内外形势有着密不可分的关系。这是吕碧城经过多年思考而得出的选择,是身为佛教徒的她对纷乱社会的拯救方式。

  10. Clinical Research on Use of Oxaliplcrtin in Combination with HCPT, LV and 5FU in a Regimen for Advanced Gastric Cancer

    Institute of Scientific and Technical Information of China (English)

    GuoqingHu; QiangFu; MaolinJin; JieLi; LiangxiPan; YuxianBai; HuaijinWang; JianweiZhang; DingYu

    2004-01-01

    OBJECTIVE To observe the effects and adverse reactions of a OXA-HCPT LV/5FU 3 regimen for patients with advanced gastric cancer.METHODS OHLF3 regimen: OXA 130 mg/m2iv d 1, HCPT6 mg/m2, iv d 1-5, LV 200 mg/m2iv 2 h followed by a 5FU 400 mg/m2 iv bolus and 5FU 600mg/m2 iv d 1-3, were given, every 21 days as 1 cycle. Assessment of the tumor was conducted after 3 cycles and the effective cases were confirmed after 4 weeks.RESULTS Among 39 patients, 36 were actually evaluable. Overall response rates (CR + PR} were 50%' the major adverse reactions were mild hematological toxicity, nausea and vomiting and peripheral nerve abnormalities.CONCLUSION The OHLF 3 regimen using OXA and HCPT is effective and results in mild toxicity when used in combined chemotherapy for advanced gastric cancer.

  11. Coinfection of Leishmania chagasi with Toxoplasma gondii, Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) in cats from an endemic area of zoonotic visceral leishmaniasis.

    Science.gov (United States)

    Sobrinho, Ludmila Silva Vicente; Rossi, Cláudio Nazaretian; Vides, Juliana Peloi; Braga, Eveline Tozzi; Gomes, Ana Amélia Domingues; de Lima, Valéria Marçal Félix; Perri, Sílvia Helena Venturoli; Generoso, Diego; Langoni, Hélio; Leutenegger, Christian; Biondo, Alexander Welker; Laurenti, Márcia Dalastra; Marcondes, Mary

    2012-06-08

    The aim of the present study was to determine the coinfection of Leishmania sp. with Toxoplasma gondii, Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) in a population of cats from an endemic area for zoonotic visceral leishmaniasis. An overall 66/302 (21.85%) cats were found positive for Leishmania sp., with infection determined by direct parasitological examination in 30/302 (9.93%), by serology in 46/302 (15.23%) and by both in 10/302 (3.31%) cats. Real time PCR followed by amplicon sequencing successfully confirmed Leishmania infantum (syn Leishmania chagasi) infection. Out of the Leishmania infected cats, coinfection with FIV was observed in 12/66 (18.18%), with T. gondii in 17/66 (25.75%) and with both agents in 5/66 (7.58%) cats. FeLV was found only in a single adult cat with no Leishmania infection. A positive association was observed in coinfection of Leishmania and FIV (p0.05). In conclusion, cats living in endemic areas of visceral leishmaniasis are significantly more likely to be coinfected with FIV, which may present confounding clinical signs and therefore cats in such areas should be always carefully screened for coinfections. Copyright © 2012 Elsevier B.V. All rights reserved.

  12. Lost in Location

    DEFF Research Database (Denmark)

    Hansen, Lone Koefoed

    2009-01-01

    The article investigates how users of personal satellite navigation devices (often referred to as sat-nav) are sometimes lost and led astray and argues that the satnav's aim to remove every insecurity about the correct route seems to remove the individual's conscious perception of the space...... performance, the article examines how the growing locative media industry can learn from the location-aware performative strategies employed by artists who create situated and urban performances for the curious participant. The academic frames employed in the analysis draw on psychogeography, site...

  13. The Use of a Quadripolar Left Ventricular Lead Increases Successful Implantation Rates in Patients with Phrenic Nerve Stimulation and/or High Pacing Thresholds Undergoing Cardiac Resynchronisation Therapy with Conventional Bipolar Leads

    OpenAIRE

    Ohlow, Marc-Alexander; Lauer, Bernward; Brunelli, Michele; Daralammouri, Yunis; Geller, Christoph

    2013-01-01

    Background Phrenic nerve stimulation (PNS) and high pacing thresholds (HPT) hinder biventricular stimulation in patients (pts) undergoing cardiac resynchronization therapy (CRT). A new quadripolar left ventricular (LV) lead (Quartet 1458Q, St. Jude Medical) with increased number of pacing configuration, might overcome this problem. Methods All consecutive pts in whom a standard bipolar lead intraoperatively resulted in PNS and/or HPT (≥4.00V/1mV), received, during the same implant, a quadripo...

  14. Location-routing problems

    Energy Technology Data Exchange (ETDEWEB)

    Laporte, G.

    1987-01-01

    Location-routing problems involve simultaneously locating a number of facilities among candidate sites and establishing delivery routes to a set of users in such a way that the total system cost is minimized. This paper presents a survey of such problems. It includes some applications and examples of location-routing problems, a description of the main heuristics that have been developed for such problems, and reviews of various formulations and algorithms used in solving these problems. A more detailed review is given of exact algorithms for the vehicle routing problem, three-index vehicle flow formulations, and two-index vehicle flow formulations and algorithms for symmetrical and non-symmetrical problems. It is concluded that location-routing problem research is a fast-growing area, with most developments occurring over the past few years; however, research is relatively fragmented, often addresses problems which are too specific and contains several voids which have yet to be filled. A number of promising research areas are identified. 137 refs., 3 figs.

  15. The Czech Locative Chameleon

    Directory of Open Access Journals (Sweden)

    Tarald Taraldsen

    2007-12-01

    Full Text Available We show that under certain circumstances, the Czech locative prepositions (LOC show up as directional prepositions (DIR and vice versa, (under different circumstances the Czech DIR PPs show up as LOC. We argue that such a chameleon life of the PPs is structurally dependent.

  16. The Czech Locative Chameleon

    OpenAIRE

    Tarald Taraldsen; Lucie Medová

    2007-01-01

    We show that under certain circumstances, the Czech locative prepositions (LOC) show up as directional prepositions (DIR) and vice versa, (under different circumstances) the Czech DIR PPs show up as LOC. We argue that such a chameleon life of the PPs is structurally dependent.

  17. Locative Inversion in English

    NARCIS (Netherlands)

    Broekhuis, H.

    2005-01-01

    This article aims at reformulating in more current terms Hoekstra and Mulder’s (1990) analysis of the Locative Inversion (LI) construction. The new proposal is crucially based on the assumption that Small Clause (SC) predicates agree with their external argument in phi-features, which may be morphol

  18. Location-based games

    DEFF Research Database (Denmark)

    Ejsing-Duun, Stine

    In this dissertation, it is explored which prerequisites are necessary in location-based games (LBGs) to make meaningful the meeting between players and spatiality with an emphasis on physical locations. Throughout the dissertation, it has been shown that LBGs affect players’ perception of and be......In this dissertation, it is explored which prerequisites are necessary in location-based games (LBGs) to make meaningful the meeting between players and spatiality with an emphasis on physical locations. Throughout the dissertation, it has been shown that LBGs affect players’ perception...... of and behavior in everyday spaces, as the games reside on the boundaries between the continuums of play and ordinary, authentic and fictional, and as they merge physical and digital media. These are termed the six dimensions of LBGs. LBGs let the player explore the boundaries between these dimensions...... experiences of being in the world and the creation of meaning. The theory on motivation defines what motivation consists of and how it relates to our actions. This theory has been combined with theories concerning play and play culture, digital media, (digital) games, (optimal) experiences, landscape...

  19. RFID Location Algorithm

    Directory of Open Access Journals (Sweden)

    Wang Zi Min

    2016-01-01

    Full Text Available With the development of social services, people’s living standards improve further requirements, there is an urgent need for a way to adapt to the complex situation of the new positioning technology. In recent years, RFID technology have a wide range of applications in all aspects of life and production, such as logistics tracking, car alarm, security and other items. The use of RFID technology to locate, it is a new direction in the eyes of the various research institutions and scholars. RFID positioning technology system stability, the error is small and low-cost advantages of its location algorithm is the focus of this study.This article analyzes the layers of RFID technology targeting methods and algorithms. First, RFID common several basic methods are introduced; Secondly, higher accuracy to political network location method; Finally, LANDMARC algorithm will be described. Through this it can be seen that advanced and efficient algorithms play an important role in increasing RFID positioning accuracy aspects.Finally, the algorithm of RFID location technology are summarized, pointing out the deficiencies in the algorithm, and put forward a follow-up study of the requirements, the vision of a better future RFID positioning technology.

  20. Crime Location Choice

    NARCIS (Netherlands)

    Bernasco, Wim; Ruiter, Stijn

    2014-01-01

    Most behavior of interest to social scientists is choice behavior: actions people commit while they could also have done something else. In geographical and environmental criminology, a new framework has emerged for analyzing individual crime location choice. It is based on the principle of random u

  1. Computation of Optimal Actuator/Sensor Locations

    Science.gov (United States)

    2013-12-26

    systematically addressed. A mechatronic approach where controller design is integrated with actuator location was used. This effort was complicated by the... Mechatronics Engineering University of Waterloo Overview Many systems, such as acoustic noise and structural vibrations are distributed in space. (See Figure 1...either impossible, or else is unlikely to lead to locations that are close to optimal. A mechatronic approach where controller design is integrated

  2. Electric current locator

    Science.gov (United States)

    King, Paul E [Corvallis, OR; Woodside, Charles Rigel [Corvallis, OR

    2012-02-07

    The disclosure herein provides an apparatus for location of a quantity of current vectors in an electrical device, where the current vector has a known direction and a known relative magnitude to an input current supplied to the electrical device. Mathematical constants used in Biot-Savart superposition equations are determined for the electrical device, the orientation of the apparatus, and relative magnitude of the current vector and the input current, and the apparatus utilizes magnetic field sensors oriented to a sensing plane to provide current vector location based on the solution of the Biot-Savart superposition equations. Description of required orientations between the apparatus and the electrical device are disclosed and various methods of determining the mathematical constants are presented.

  3. The Integrated HV, LV and Liquid Radiator Control System for the HMPID in the ALICE Experiment at LHC

    CERN Document Server

    Carrone, E; De Cataldo, G; Di Mauro, A; Franco, A; Martinengo, P; Nappi, E; Piuz, François; Schyns, E M

    2001-01-01

    The complexity and the underground location of the new generation experiments (ALICE, ATLAS, CMS and LHCb) at the CERN Large Hadron Collider (LHC) requires a reliable and user friendly control system to operate such large detectors remotely. Control system experts at CERN are deeply involved in developing the JCOP (Joint Controls Project) 'Framework', a software running in the PVSSII SCADA1 (Supervisory Control And Data Acquisition) system, that will provide a homogeneous and ready to use tool for the control system developers of the LHC experiments. The High Momentum Particle Identification Detector (HMPID), one of the ALICE2 sub-detectors, is being equipped with a Detector Control System (DCS) developed within the JCOP Framework. In this paper the basic features and the first results of the DCS prototype are presented.

  4. Toxoplasma gondii, Dirofilaria immitis, feline immunodeficiency virus (FIV), and feline leukemia virus (FeLV) infections in stray and pet cats (Felis catus) in northwest China: co-infections and risk factors.

    Science.gov (United States)

    Cong, Wei; Meng, Qing-Feng; Blaga, Radu; Villena, Isabelle; Zhu, Xing-Quan; Qian, Ai-Dong

    2016-01-01

    This study was conducted to estimate the prevalence of Toxoplasma gondii, Dirofilaria immitis, feline immunodeficiency virus (FIV), and feline leukemia virus (FeLV) infections among stray and pet cats in Lanzhou, northwest China, and to identify the influence of age, gender, and regions on seropositivity. T. gondii antibodies were examined in cat sera by the modified agglutination test (MAT). The circulating antigens of D. immitis and FeLV and specific antibodies to FIV were examined using kits commercially available. The overall prevalence of T. gondii, FIV, FeLV, and D. immitis was 19.34, 9.12, 11.33, and 3.04 %, respectively. For the genetic characterization of T. gondii genotypes in cats, genomic DNA was extracted from the seropositive cats and the T. gondii B1 gene was amplified using a semi-nested PCR. DNA samples giving positive B1 amplification were then genotyped using multilocus PCR-RFLP. Two T. gondii genotypes (ToxoDB#9 and ToxoDB#1) were identified. Results of the multivariate logistic regression analysis showed that older cats are more likely to be seropositive than juveniles for T. gondii, FIV, FeLV, and D. immitis. This is the first report of T. gondii genotypes in cats in northwest China. Moreover, the present study is the first study of retrovirus and D. immitis seroprevalence in cats in China. The results revealed that T. gondii, FIV, and FeLV infections are common in stray and pet cats in northwest China.

  5. Fits to Moment Measurements from B->Xc lv and B-> Xs gamma Decays using Heavy Quark Expansions in the Kinetic Scheme

    CERN Document Server

    Buchmüller, O L; Buchmueller, Oliver; Flaecher, Henning

    2006-01-01

    We present a fit to moment measurements of inclusive distributions in B->Xc lv and B->Xs gamma decays to extract values for the CKM matrix element |Vcb|, the b- and c- quark masses, and higher order parameters that appear in the Heavy Quark Expansion. The fit is carried out using theoretical calculations in the kinetic scheme and includes moment measurements of the BaBar, Belle, CDF, CLEO and DELPHI collaborations where correlation matrices have been published. We also derive values for the heavy quark distribution function parameters $m_b$ and $\\mu_{\\pi}^2$ in different theoretical schemes that can be used as input for the evaluation of the associated theory error on |Vub|.

  6. Immigrants' location preferences

    DEFF Research Database (Denmark)

    Damm, Anna Piil

    This paper exploits a spatial dispersal policy for refugee immigrants to estimate the importance of local and regional factors for refugees' location preferences. The main results of a mixed proportional hazard competing risks model are that placed refugees react to high regional unemployment...... and lack of a local immigrant population by migrating to large municipalities. Lack of local fellow countrymen, however, increases the exit rate to medium-sized as well as large municipalities. This finding is likely to be a result of the dispersal policy. Finally, refugees react strongly to assignment...

  7. Association of left ventricular mechanical dyssynchrony with survival benefit from revascularization: a study of gated positron emission tomography in patients with ischemic LV dysfunction and narrow QRS

    Energy Technology Data Exchange (ETDEWEB)

    AlJaroudi, Wael [Imaging Institute, Heart and Vascular, Cleveland, OH (United States); Sydell and Arnold Miller Family Heart and Vascular Institute, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland, OH (United States); Alraies, M.C. [Cleveland Clinic, Department of Hospital Medicine, Cleveland, OH (United States); Hachamovitch, Rory; Jaber, Wael A.; Brunken, Richard; Cerqueira, Manuel D.; Marwick, Thomas [Imaging Institute, Heart and Vascular, Cleveland, OH (United States)

    2012-10-15

    LV mechanical dyssynchrony (LVMD) is a risk marker in narrow QRS cardiomyopathy, but its association with treatment outcome is not well defined. We determined the incremental prognostic value of LVMD in ischemic cardiomyopathy, and assessed its interaction with scar, myocardium in jeopardy and subsequent revascularization. Stress and rest {sup 82}Rb gated PET were performed in 486 consecutive patients (66 {+-} 11 years of age, 82 % men, LV ejection fraction 26 {+-} 6 %) with ischemic cardiomyopathy and QRS <120 ms. LVMD was determined as the standard deviation (SD) of the regional time to minimum volume on phase analysis of the gated PET scan. A propensity score was determined to adjust for nonrandomized referral after imaging to coronary artery bypass grafting (CABG). In a Cox proportional hazards model used to determine the association between measures of LVMD and survival time, CABG was included as a time-dependent covariate and the use of an implantable cardiac defibrillator (ICD) after imaging was modeled as a stratification factor. Over 1.9 {+-} 1.4 years, 96 patients (20 %) underwent CABG and 108 (22 %) died. LVMD was a predictor of mortality (HR 1.16. 95 % CI 1.03;1.30, per 10 increase in phase SD, p = 0.02) after adjusting for baseline covariates, prior ICD use, the use of postimaging CABG, and other imaging data. There was a significant interaction between phase SD and CABG. Nested Cox models showed that LVMD carried prognostic information incremental to clinical variables, ejection fraction and CABG. LVMD is an independent predictor of all-cause mortality in ischemic cardiomyopathy, and may identify patients with a differential survival benefit from CABG versus medical therapy. (orig.)

  8. MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis.

    Science.gov (United States)

    Johnson, Radia M; Papp, Eniko; Grandal, Ildiko; Kowalski, Paul E; Nutter, Lauryl; Wong, Raymond C C; Joseph-George, Ann M; Danska, Jayne S; Guidos, Cynthia J

    2014-06-01

    During V(D)J recombination of immunoglobulin genes, p53 and nonhomologous end-joining (NHEJ) suppress aberrant rejoining of DNA double-strand breaks induced by recombinase-activating genes (Rags)-1/2, thus maintaining genomic stability and limiting malignant transformation during B-cell development. However, Rag deficiency does not prevent B-cell leukemogenesis in p53/NHEJ mutant mice, revealing that p53 and NHEJ also suppress Rag-independent mechanisms of B-cell leukemogenesis. Using several cytogenomic approaches, we identified a novel class of activating mutations in Fms-like tyrosine kinase 3 (Flt3), a receptor tyrosine kinase important for normal hematopoiesis in Rag/p53/NHEJ triple-mutant (TM) B-cell leukemias. These mutant Flt3 alleles were created by complex genomic rearrangements with Moloney leukemia virus (MuLV)-related endogenous retroviral (ERV) elements, generating ERV-Flt3 fusion genes encoding an N-terminally truncated mutant form of Flt3 (trFlt3) that was transcribed from ERV long terminal repeats. trFlt3 protein lacked most of the Flt3 extracellular domain and induced ligand-independent STAT5 phosphorylation and proliferation of hematopoietic progenitor cells. Furthermore, expression of trFlt3 in p53/NHEJ mutant hematopoietic progenitor cells promoted development of clinically aggressive B-cell leukemia. Thus, repetitive MuLV-related ERV sequences can participate in aberrant end-joining events that promote development of aggressive B-cell leukemia. © 2014 Johnson et al.; Published by Cold Spring Harbor Laboratory Press.

  9. General minisum circle location

    DEFF Research Database (Denmark)

    Körner, Mark; Brimberg, Jack; Juel, Henrik

    2009-01-01

    In our paper we approximate a set of given points by a general circle. More precisely, we consider the problem of locating and scaling the unit ball of some given norm k1 with respect to xed points on the plane such that the sum of weighted distances between the circle and the xed points is minim......In our paper we approximate a set of given points by a general circle. More precisely, we consider the problem of locating and scaling the unit ball of some given norm k1 with respect to xed points on the plane such that the sum of weighted distances between the circle and the xed points...... is minimized, where the distance is measured by a norm k2. We present results for the general case. In the case that k1 and k2 are both block norms, we are able to identify a nite dominating set in R3 for the problem, which can be obtained as the intersection of cones....

  10. Indoor Location Technologies

    CERN Document Server

    Goswami, Subrata

    2013-01-01

    Focusing on the special challenges posed by accurately pinpointing a location indoors, this volume reflects the distance we have come in the handful of decades since the germination of GPS technology. Not only can we locate a signal to within a meter’s accuracy, but we now have this technology in the most basic mobile phone. Tracing recent practical developments in positioning technology and in the market it supplies, the author examines the contributions of the varied research—in silicon, signal and image processing, radio communications and software—to a fast-evolving field. The book looks forward to a time when, in addition to directing your road journey, positioning systems can peer indoors and guide you to an available photocopier in your office building. Featuring standalone chapters each dealing with a specific aspect of the subject, including treatments of systems such as Zebra, Awarepoint, Aeroscout, IEEE 802.11, etc. This study has all the detail needed to get up to speed on a key modern techn...

  11. Development of tools to manage the operational monitoring and pre-design of the NPP-LV cycle; Desarrollo de herramientas para administrar el seguimiento operativo y el pre-diseno del ciclo de la CLV

    Energy Technology Data Exchange (ETDEWEB)

    Perusquia, R.; Arredondo S, C.; Hernandez M, J. L.; Montes T, J. L.; Castillo M, A.; Ortiz S, J. J., E-mail: raul.perusquia@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2015-09-15

    This paper presents the development of tools to facilitate the management so much, the operational monitoring of boiling water reactors (BWR) of the nuclear power plant of Laguna Verde (NPP-LV) through independent codes, and how to carry out the static calculations corresponding to process of optimized pre-design of the reference cycle next to current cycle. The progress and preliminary results obtained with the program SACal, developed at Instituto Nacional de Investigaciones Nucleares (ININ), central tool to achieve provide a management platform of the operational monitoring and pre-design of NPP-LV cycle are also described. The reached preliminary advances directed to get an Analysis center and automated design of fuel assembly cells are also presented, which together with centers or similar modules related with the fuel reloads form the key part to meet the targets set for the realization of a Management Platform of Nuclear Fuel of the NPP-LV. (Author)

  12. Locating Nordic Noir

    DEFF Research Database (Denmark)

    Hansen, Kim Toft; Waade, Anne Marit

    This book is a comprehensive study of Nordic Noir television drama from the 1990’s until today. The authors introduce the history of contemporary Nordic Noir from the perspective of place, production and location studies. The chapters include readings of well-known television crime dramas...... production in Sweden, Denmark, Norway and Iceland. Consequently, Nordic Noir is read as both a transnational financial and creative phenomenon and as a local possibility for community building. The book is aimed at readers with an interest in crime drama as well as television scholars and students...... of television drama, and it offers a comprehensible, scholarly and methodologically original approach to the popularity of Nordic television crime dramas....

  13. Quantum Image Location

    Science.gov (United States)

    Jiang, Nan; Dang, Yijie; Zhao, Na

    2016-10-01

    Quantum image processing has been a hot topic as a consequence of the development of quantum computation. Many quantum image processing algorithms have been proposed, whose efficiency are theoretically higher than their corresponding classical algorithms. However, most of the quantum schemes do not consider the problem of measurement. If users want to get the results, they must measure the final state many times to get all the pixels' values. Moreover, executing the algorithm one time, users can only measure the final state one time. In order to measure it many times, users must execute the algorithms many times. If the measurement process is taken into account, whether or not the algorithms are really efficient needs to be reconsidered. In this paper, we try to solve the problem of measurement and give a quantum image location algorithm. This scheme modifies the probability of pixels to make the target pixel to be measured with higher probability. Furthermore, it only has linear complexity.

  14. Local electrogram delay recorded from left ventricular lead at implant predicts response to cardiac resynchronization therapy: Retrospective study with 1 year follow up

    Directory of Open Access Journals (Sweden)

    Polasek Rostislav

    2012-05-01

    Full Text Available Abstract Background Considerable proportion of patients does not respond to the cardiac resynchronization therapy (CRT. This study investigated clinical relevance of left ventricular electrode local electrogram delay from the beginning of QRS (QLV. We hypothesized that longer QLV indicating more optimal lead placement in the late activated regions is associated with the higher probability of positive CRT response. Methods We conducted a retrospective, single–centre analysis of 161 consecutive patients with heart failure and LBBB or nonspecific intraventricular conduction delay (IVCD treated with CRT. We routinely intend to implant the LV lead in a region with long QLV. Clinical response to CRT, left ventricular (LV reverse remodelling (i.e. decrease in LV end-systolic diameter - LVESD ≥10% and reduction in plasma level of NT-proBNP >30% at 12-month post-implant were the study endpoints. We analyzed association between pre-implant variables and the study endpoints. Results Clinical CRT response rate reached 58%, 84% and 92% in the lowest (≤105 ms, middle (106-130 ms and the highest (>130 ms QLV tertile (p  Conclusion LV lead position assessed by duration of the QLV interval was found the strongest independent predictor of beneficial clinical response to CRT.

  15. Locating Depots for Capacitated Vehicle Routing

    DEFF Research Database (Denmark)

    Gørtz, Inge Li; Nagarajan, Viswanath

    2016-01-01

    We study a location-routing problem in the context of capacitated vehicle routing. The input to the k-location capacitated vehicle routing problem (k-LocVRP) consists of a set of demand locations in a metric space and a fleet of k identical vehicles, each of capacity Q. The objective is to locate k...... depots, one for each vehicle, and compute routes for the vehicles so that all demands are satisfied and the total cost is minimized. Our main result is a constant-factor approximation algorithm for k-LocVRP. In obtaining this result, we introduce a common generalization of the k-median and minimum...... spanning tree problems (called k median forest), which might be of independent interest. We give a local-search based (3+ε)-approximation algorithm for k median forest, which leads to a (12+ε)-approximation algorithm for k-LocVRP, for any constant ε>0....

  16. Recruiting in remote locations

    Energy Technology Data Exchange (ETDEWEB)

    Ionel, C. [Enerflex Systems Ltd., Calgary, AB (Canada)

    2006-07-01

    This presentation provided details of Enerflex, a leading supplier of products and services to the oil and gas industry, and outlined their personnel hiring policies. Enerflex's core values include community involvement and divisional logo branding. The extensive training that is provided places an emphasis on employee empowerment. The company also places an emphasis on employee safety, diversity, and team building. Competitive salaries are offered along with generous equipment allowances and a flexible benefits program. Benefits include travel and overtime rates; health benefits; retirement savings; scholarship programs; career opportunities; and apprenticeship programs. External technical training is provided. An employee referral program has been developed, and the company's recruitment program also advertises in remote newspapers to develop career streams within remote communities. tabs., figs.

  17. On location at CERN

    CERN Multimedia

    Joannah Caborn Wengler

    2012-01-01

    CERN continues to be a very popular candidate for film locations at the moment. Not only has it inspired a German author and a film-maker interested in the more exotic interpretations of the science being worked on at the Organization, but even the recent puppet animation film by the legendary Muppets featured some CERN scenes.   Dr Bunsen Honeydew (far left) and his friends at ATLAS. Beaker, Bunsen's assistant, has just been sucked up the vacuum tube top left... Image courtesy Walt Disney Studios. In “The Muppet Movie”, released in November 2011 in North America and world-wide in January and February this year, Kermit is reuniting his friends who have ended up in some far-flung places since they last worked together 10 years ago. CERN caught the imagination of the film-makers as the perfect place for the Muppet scientists, Dr. Honeydew Bunsen and his hapless assistant Beaker. After a brief scene filmed in front of a backdrop of the ATLAS detector, the rest of the ...

  18. Hypertrophic Cardiomyopathy: How do Mutations Lead to Disease?

    Energy Technology Data Exchange (ETDEWEB)

    Marsiglia, Júlia Daher Carneiro, E-mail: julia.marsiglia@usp.br; Pereira, Alexandre Costa [Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil)

    2014-03-15

    Hypertrophic cardiomyopathy (HCM) is the most common monogenic genetic cardiac disease, with an estimated prevalence of 1:500 in the general population. Clinically, HCM is characterized by hypertrophy of the left ventricle (LV) walls, especially the septum, usually asymmetric, in the absence of any cardiac or systemic disease that leads to a secondary hypertrophy. The clinical course of the disease has a large inter- and intrafamilial heterogeneity, ranging from mild symptoms of heart failure late in life to the onset of sudden cardiac death at a young age and is caused by a mutation in one of the genes that encode a protein from the sarcomere, Z-disc or intracellular calcium modulators. Although many genes and mutations are already known to cause HCM, the molecular pathways that lead to the phenotype are still unclear. This review focus on the molecular mechanisms of HCM, the pathways from mutation to clinical phenotype and how the disease's genotype correlates with phenotype.

  19. Lead Poisoning Prevention Tips

    Science.gov (United States)

    ... or removed safely. How are children exposed to lead? Lead-based paint and lead contaminated dust are ... What can be done to prevent exposure to lead? It is important to determine the construction year ...

  20. Lead (Pb) Air Pollution

    Science.gov (United States)

    ... States Environmental Protection Agency Search Search Lead (Pb) Air Pollution Share Facebook Twitter Google+ Pinterest Contact Us As ... and protect aquatic and terrestrial ecosystems. Lead (Pb) Air Pollution Lead Air Pollution Basics How does lead get ...

  1. Costly location in Hotelling duopoly

    NARCIS (Netherlands)

    Hinloopen, J.; Martin, S.

    2013-01-01

    We introduce a cost of location into Hotelling’s (1929) spatial duopoly. We derive the general conditions on the cost-of-location function under which a pure strategy price-location Nash equilibrium exists. With linear transportation cost and a suitably specified cost of location that rises toward

  2. Variation in turbidity with precipitation and flow in a regulated river system – river Göta Älv, SW Sweden

    Directory of Open Access Journals (Sweden)

    G. Göransson

    2013-07-01

    Full Text Available The turbidity variation in time and space is investigated in the downstream stretch of the river Göta Älv in Sweden. The river is heavily regulated and carries the discharge from the largest fresh water lake in Sweden, Lake Vänern, to the outflow point in Göteborg Harbour on the Swedish west coast. The river is an important waterway and serves as a fresh-water supply for 700 000 users. Turbidity is utilised as a water quality indicator to ensure sufficient quality of the intake water to the treatment plant. The overall objective of the study was to investigate the influence of rainfall, surface runoff, and river water flow on the temporal and spatial variability of the turbidity in the regulated river system by employing statistical analysis of an extensive data set. A six year long time series of daily mean values on precipitation, discharge, and turbidity from six stations along the river were examined primarily through linear correlation and regression analysis, combined with nonparametric tests and analysis of variance. The analyses were performed on annual, monthly, and daily bases, establishing temporal patterns and dependences, including; seasonal changes, impacts from extreme events, influences from tributaries, and the spatial variation along the river. The results showed that there is no simple relationship between discharge, precipitation, and turbidity, mainly due to the complexity of the runoff process, the regulation of the river, and the effects of Lake Vänern and its large catchment area. For the river Göta Älv, significant, positive correlations between turbidity, discharge, and precipitation could only be found during periods with high flow combined with heavy rainfall. Local precipitation does not seem to have any significant impact on the discharge in the main river, which is primarily governed by precipitation at catchment scale. The discharge from Lake Vänern determines the base level for the turbidity in the river

  3. Lead Aprons Are a Lead Exposure Hazard.

    Science.gov (United States)

    Burns, Kevin M; Shoag, Jamie M; Kahlon, Sukhraj S; Parsons, Patrick J; Bijur, Polly E; Taragin, Benjamin H; Markowitz, Morri

    2017-05-01

    To determine whether lead-containing shields have lead dust on the external surface. Institutional review board approval was obtained for this descriptive study of a convenience sample of 172 shields. Each shield was tested for external lead dust via a qualitative rapid on-site test and a laboratory-based quantitative dust wipe analysis, flame atomic absorption spectrometry (FAAS). The χ(2) test was used to test the association with age, type of shield, lead sheet thickness, storage method, and visual and radiographic appearance. Sixty-three percent (95% confidence interval [CI]: 56%-70%) of the shields had detectable surface lead by FAAS and 50% (95% CI: 43%-57%) by the qualitative method. Lead dust by FAAS ranged from undetectable to 998 μg/ft(2). The quantitative detection of lead was significantly associated with the following: (1) visual appearance of the shield (1 = best, 3 = worst): 88% of shields that scored 3 had detectable dust lead; (2) type of shield: a greater proportion of the pediatric patient, full-body, and thyroid shields were positive than vests and skirts; (3) use of a hanger for storage: 27% of shields on a hanger were positive versus 67% not on hangers. Radiographic determination of shield intactness, thickness of interior lead sheets, and age of shield were unrelated to presence of surface dust lead. Sixty-three percent of shields had detectable surface lead that was associated with visual appearance, type of shield, and storage method. Lead-containing shields are a newly identified, potentially widespread source of lead exposure in the health industry. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  4. Effects of Benzalkonium Chloride, Proxel LV, P3 Hypochloran, Triton X-100 and DOWFAX 63N10 on anaerobic digestion processes.

    Science.gov (United States)

    Flores, German Antonio Enriquez; Fotidis, Ioannis A; Karakashev, Dimitar Borisov; Kjellberg, Kasper; Angelidaki, Irini

    2015-10-01

    In this study, the individual and synergistic toxicity of the following xenobiotics: Benzalkonium Chloride (BKC), Proxel LV (PRX), P3 Hypochloran (HPC), Triton X-100 (TRX), and DOWFAX 63N10 (DWF), on anaerobic digestion (AD) process, was assessed. The experiments were performed in batch and continuous (up-flow anaerobic sludge blanket, UASB) reactors with biochemical-industrial wastewater, as substrate. In batch experiments, half-maximal inhibitory concentrations (IC50) for the tested xenobiotics were found to be 13.1, 1003, 311.5 and 24.3 mg L(-1) for BKC, PRX, DWF and TRX, respectively while HPC did not affect the AD process. Furthermore, the xenobiotics mixture tested did not present any synergistic inhibitory effect on the AD process. In continuous experiments, BKC and xenobiotics' mixture induced even stronger (more than 85%) of inhibition, expressed as IC50, compared to the levels observed from the batch reactors. Oppositely, TRX showed no inhibition in continuous mode, while inhibition was detected at batch mode.

  5. Delivery of an engineered HGF fragment in an extracellular matrix-derived hydrogel prevents negative LV remodeling post-myocardial infarction.

    Science.gov (United States)

    Sonnenberg, Sonya B; Rane, Aboli A; Liu, Cassie J; Rao, Nikhil; Agmon, Gillie; Suarez, Sophia; Wang, Raymond; Munoz, Adam; Bajaj, Vaibhav; Zhang, Shirley; Braden, Rebecca; Schup-Magoffin, Pamela J; Kwan, Oi Ling; DeMaria, Anthony N; Cochran, Jennifer R; Christman, Karen L

    2015-03-01

    Hepatocyte growth factor (HGF) has been shown to have anti-fibrotic, pro-angiogenic, and cardioprotective effects; however, it is highly unstable and expensive to manufacture, hindering its clinical translation. Recently, a HGF fragment (HGF-f), an alternative c-MET agonist, was engineered to possess increased stability and recombinant expression yields. In this study, we assessed the potential of HGF-f, delivered in an extracellular matrix (ECM)-derived hydrogel, as a potential treatment for myocardial infarction (MI). HGF-f protected cardiomyocytes from serum-starvation and induced down-regulation of fibrotic markers in whole cardiac cell isolate compared to the untreated control. The ECM hydrogel prolonged release of HGF-f compared to collagen gels, and in vivo delivery of HGF-f from ECM hydrogels mitigated negative left ventricular (LV) remodeling, improved fractional area change (FAC), and increased arteriole density in a rat myocardial infarction model. These results indicate that HGF-f may be a viable alternative to using recombinant HGF, and that an ECM hydrogel can be employed to increase growth factor retention and efficacy.

  6. Effect of HPMC - E15 LV premium polymer on release profile and compression characteristics of chitosan/ pectin colon targeted mesalamine matrix tablets and in vitro study on effect of pH impact on the drug release profile.

    Science.gov (United States)

    Newton, A M J; Lakshmanan, Prabakaran

    2014-04-01

    The study was designed to investigate the in vitro dissolution profile and compression characteristics of colon targeted matrix tablets prepared with HPMC E15 LV in combination with pectin and Chitosan. The matrix tablets were subjected to two dissolution models in various simulated fluids such as pH 1.2, 6, 6.8, 7.2, 5.5. The fluctuations in colonic pH conditions during IBD (inflammatory bowel disease) and the nature of less fluid content in the colon may limit the expected drug release in the polysaccharide-based matrices when used alone. The Hydrophilic hydroxyl propyl methylcellulose ether premium polymer (HPMC E15 LV) of low viscosity grade was used in the formulation design, which made an excellent modification in physical and compression characteristics of the granules. The release studies indicated that the prepared matrices could control the drug release until the dosage form reaches the colon and the addition HPMC E15 LV showed the desirable changes in the dissolution profile by its hydrophilic nature since the colon is known for its less fluid content. The hydrophilic HPMC E15 LV allowed the colonic fluids to enter into the matrix and confirmed the drug release at the target site from a poorly water soluble polymer such as Chitosan and also from water soluble Pectin. The dramatic changes occurred in the drug release profile and physicochemical characteristics of the Pectin, Chitosan matrix tablets when a premium polymer HPMC E15 LV added in the formulation design in the optimized concentration. Various drug release mechanisms used for the examination of drug release characteristics. Drug release followed the combined mechanism of diffusion, erosion, swelling and polymer entanglement. In recent decade, IBD attracts many patents in novel treatment methods by using novel drug delivery systems.

  7. Lead and the Romans

    Science.gov (United States)

    Reddy, Aravind; Braun, Charles L.

    2010-01-01

    Lead poisoning has been a problem since early history and continues into modern times. An appealing characteristic of lead is that many lead salts are sweet. In the absence of cane and beet sugars, early Romans used "sugar of lead" (lead acetate) to sweeten desserts, fruits, and sour wine. People most at risk would have been those who…

  8. Lead and the Romans

    Science.gov (United States)

    Reddy, Aravind; Braun, Charles L.

    2010-01-01

    Lead poisoning has been a problem since early history and continues into modern times. An appealing characteristic of lead is that many lead salts are sweet. In the absence of cane and beet sugars, early Romans used "sugar of lead" (lead acetate) to sweeten desserts, fruits, and sour wine. People most at risk would have been those who consumed the…

  9. ICE Online Detainee Locator System

    Data.gov (United States)

    Department of Homeland Security — The Online Detainee Locator datasets provide the location of a detainee who is currently in ICE custody, or who was release from ICE custody for any reason with the...

  10. Duality in constrained location problems

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1987-01-01

    The dual of a facility location problem with general norms, distance constraints, and linear constraints is formulated.......The dual of a facility location problem with general norms, distance constraints, and linear constraints is formulated....

  11. Duality in constrained location problems

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1987-01-01

    The dual of a facility location problem with general norms, distance constraints, and linear constraints is formulated.......The dual of a facility location problem with general norms, distance constraints, and linear constraints is formulated....

  12. 全球化背景下核型创新网络竞争机制研究--基于改进LV-EG模型的仿真分析%Study on Competition Mechanism of Core-structure Innovation Network under the Circumstance of Globalization-A Simulation Study Based on LV-EG Model

    Institute of Scientific and Technical Information of China (English)

    孙冰; 姚洪涛

    2016-01-01

    在全球化背景下,核型创新网络在向全球创新网络演进的过程中面临多市场竞争和关键资源竞争的双重考验。首先构建全球市场环境下核型创新网络多层次竞合模型;其次,运用Lotka-Volterra模型和演化博弈模型分别剖析核心企业间的竞争关系和尾端企业间的竞合关系,并据此构建改进的LV-EG模型以分析尾端企业竞合关系对核心企业间竞争关系的作用机理;最后,运用matlab对改进的LV-EG模型进行仿真。仿真结果表明:核心企业的尾端企业报酬支付能力、创新产品生产能力、创新环境和网络结构对核型创新网络在全球范围内吸引优质企业并在全球市场环境中获取竞争优势具有重要影响。%Under the circumstance of globalization , core-structure innovation network faces dual challenge of multi-market competition and key resources competition in the process of development where the revolution of core -struc-ture innovation network is to global innovation network .Therefore , we firstly establish the model of core-structure innovation network ’ s multi-level coopetition under the global market environment .And then we expound core-firms’ competition and end-firms’ coopetition by applying and the Lotka-Volterra model and the evolutionary game model.Finally, we simulate and analyze this process by applying matlab software to the LV -EG model and come to the conclusion that core-firm’ s ability of paying to end-firms and production capacity of innovative products , the innovation environment and the network structure influence greatly on core -firms’ ability to attract end-firms from the global world and core-firms’ s competitive advantage under the global market environment .

  13. Jinde Lead lead smelting project starts construction

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>On Dec.20,the lead smelting project of Jiangxi Jinde Lead started construction in Dexin as a technical renovation project on environmental treatment of Jiangxi Metallurgical Group.The project is the one with the largest investment of Provincial Metallurgical Group in non-ferrous

  14. The identification of lead ammunition as a source of lead exposure in First Nations: The use of lead isotope ratios

    Energy Technology Data Exchange (ETDEWEB)

    Tsuji, Leonard J.S. [Department of Environment and Resource Studies, University of Waterloo, Waterloo, Ontario, N2L 3G1 (Canada)], E-mail: ljtsuji@fes.uwaterloo.ca; Wainman, Bruce C. [Faculty of Health Sciences, McMaster University, Hamilton, Ontario, L8N 3Z5 (Canada); Martin, Ian D. [Department of Environment and Resource Studies, University of Waterloo, Waterloo, Ontario, N2L 3G1 (Canada); Sutherland, Celine [Attawapiskat First Nation Health Services, Attawapiskat, Ontario, P0L 1A0 (Canada); Weber, Jean-Philippe; Dumas, Pierre [Centre de toxicologie, Institut national de sante publique du Quebec, Quebec City, Quebec, G1V 5B3 (Canada); Nieboer, Evert [Faculty of Health Sciences, McMaster University, Hamilton, Ontario, L8N 3Z5 (Canada); Institute of Community Medicine, University of Tromso, Tromso N-9037 (Norway)

    2008-04-15

    The use of lead shotshell to hunt water birds has been associated with lead-contamination in game meat. However, evidence illustrating that lead shotshell is a source of lead exposure in subsistence hunting groups cannot be deemed definitive. This study seeks to determine whether lead shotshell constitutes a source of lead exposure using lead isotope ratios. We examined stable lead isotope ratios for lichens, lead shotshell and bullets, and blood from residents of Fort Albany and Kashechewan First Nations, and the City of Hamilton, Ontario, Canada. Data were analyzed using ANOVA and regression analyses. ANOVA of isotope ratios for blood revealed significant differences with respect to location, but not sex. Hamilton differed from both Kashechewan and Fort Albany; however, the First Nations did not differ from each other. ANOVA of the isotope ratios for lead ammunition and lichens revealed no significant differences between lichen groups (north and south) and for the lead ammunition sources (pellets and bullets). A plot of {sup 206}Pb/{sup 204}Pb and {sup 206}Pb/{sup 207}Pb values illustrated that lichens and lead ammunition were distinct groupings and only the 95% confidence ellipse of the First Nations group overlapped that of lead ammunition. In addition, partial correlations between blood-lead levels (adjusted for age) and isotope ratios revealed significant (p < 0.05) positive correlations for {sup 206}Pb/{sup 204}Pb and {sup 206}Pb/{sup 207}Pb, and a significant negative correlation for {sup 208}Pb/{sup 206}Pb, as predicted if leaded ammunition were the source of lead exposure. In conclusion, lead ammunition was identified as a source of lead exposure for First Nations people; however, the isotope ratios for lead shotshell pellets and bullets were indistinguishable. Thus, lead-contaminated meat from game harvested with lead bullets may also be contributing to the lead body burden.

  15. Lead - nutritional considerations

    Science.gov (United States)

    Lead poisoning - nutritional considerations; Toxic metal - nutritional considerations ... Markowitz M. Lead poisoning. In: Kliegman RM, Behrman RE, Jenson HB, ... Emergency Medicine: Concepts and Clinical Practice . 8th ed. ...

  16. Location theory a unified approach

    CERN Document Server

    Nickel, Stefan

    2006-01-01

    Although modern location theory is now more than 90 years old, the focus of researchers in this area has been mainly problem oriented. However, a common theory, which keeps the essential characteristics of classical location models, is still missing.This monograph addresses this issue. A flexible location problem called the Ordered Median Problem (OMP) is introduced. For all three main subareas of location theory (continuous, network and discrete location) structural properties of the OMP are presented and solution approaches provided. Numerous illustrations and examples help the reader to bec

  17. Location-based Web Search

    Science.gov (United States)

    Ahlers, Dirk; Boll, Susanne

    In recent years, the relation of Web information to a physical location has gained much attention. However, Web content today often carries only an implicit relation to a location. In this chapter, we present a novel location-based search engine that automatically derives spatial context from unstructured Web resources and allows for location-based search: our focused crawler applies heuristics to crawl and analyze Web pages that have a high probability of carrying a spatial relation to a certain region or place; the location extractor identifies the actual location information from the pages; our indexer assigns a geo-context to the pages and makes them available for a later spatial Web search. We illustrate the usage of our spatial Web search for location-based applications that provide information not only right-in-time but also right-on-the-spot.

  18. Location of Urban Logistic Terminals as Hub Location Problem

    Directory of Open Access Journals (Sweden)

    Jasmina Pašagić Škrinjar

    2012-09-01

    Full Text Available In this paper the problems of locating urban logistic terminals are studied as hub location problems that due to a large number of potential nodes in big cities belong to hard non-polynomial problems, the so-called NP-problems. The hub location problems have found wide application in physical planning of transport and telecommunication systems, especially systems of fast delivery, networks of logistic and distribution centres and cargo traffic terminals of the big cities, etc. The paper defines single and multiple allocations and studies the numerical examples. The capacitated single allocation hub location problems have been studied, with the provision of a mathematical model of selecting the location for the hubs on the network. The paper also presents the differences in the possibilities of implementing the exact and heuristic methods to solve the actual location problems of big dimensions i.e. hub problems of the big cities.

  19. The Ibibio Locative Copular Constructions

    Directory of Open Access Journals (Sweden)

    Ogbonna Anyanwu

    2010-10-01

    Full Text Available The Ibibio language, a member of the Lower Cross group of languages is predominantly spoken in Akwa Ibom State, Nigeria. Ibibio has two types of copular construction. One is locative while the other is predicative. Using a purely descriptive approach/method, this paper provides a descriptive account of the copular locative constructions in Ibibio. This study is based on a database collected from adult speakers of Ibibio by the author using an elicitation list. The database includes both actual and potential words/sentences, which standard Ibibio speakers found to be in consistent with their language rules.The paper has observed that Ibibio copular locatives make use of locative copular verbs which have semantic content, but are however, with indeterminate locative precision except when they co- occur with an appropriate locative complement. It has further observed that in Ibibio, the location of a subject entity can be marked with locative elements in two ways. In the first instance, a locative copular verb which can be dórò, ‘be on’ síne ‘be in’ bà ‘be at’ obligatorily co-occurs with a deitic locative complement or a locative prepositional phrase (PP complement headed by a multipurpose preposition (P, ké. The P is semantically, interpreted as either on, in, at or under depending on the particular locative copular verb that it co-occurs with. In the second instance, in addition to the locative copular verb and the locative PP complement headed by the P ké, there is also within the PP complement (headed by the P ké , a locative relational noun modifier which, modifies the head noun, a complement to the locative P ké. Based on Ameka andOgbonna Anyanwu71Levinson’s (2007 cross-linguistic classification of positional and locative verbs, the paper concludes that Ibibio belongs to the multi-verb type of languages with inherently locative copular verbs which are used to express the spatial locative orientation of subject

  20. The identification of lead ammunition as a source of lead exposure in First Nations: the use of lead isotope ratios.

    Science.gov (United States)

    Tsuji, Leonard J S; Wainman, Bruce C; Martin, Ian D; Sutherland, Celine; Weber, Jean-Philippe; Dumas, Pierre; Nieboer, Evert

    2008-04-15

    The use of lead shotshell to hunt water birds has been associated with lead-contamination in game meat. However, evidence illustrating that lead shotshell is a source of lead exposure in subsistence hunting groups cannot be deemed definitive. This study seeks to determine whether lead shotshell constitutes a source of lead exposure using lead isotope ratios. We examined stable lead isotope ratios for lichens, lead shotshell and bullets, and blood from residents of Fort Albany and Kashechewan First Nations, and the City of Hamilton, Ontario, Canada. Data were analyzed using ANOVA and regression analyses. ANOVA of isotope ratios for blood revealed significant differences with respect to location, but not sex. Hamilton differed from both Kashechewan and Fort Albany; however, the First Nations did not differ from each other. ANOVA of the isotope ratios for lead ammunition and lichens revealed no significant differences between lichen groups (north and south) and for the lead ammunition sources (pellets and bullets). A plot of (206)Pb/(204)Pb and (206)Pb/(207)Pb values illustrated that lichens and lead ammunition were distinct groupings and only the 95% confidence ellipse of the First Nations group overlapped that of lead ammunition. In addition, partial correlations between blood-lead levels (adjusted for age) and isotope ratios revealed significant (pleaded ammunition were the source of lead exposure. In conclusion, lead ammunition was identified as a source of lead exposure for First Nations people; however, the isotope ratios for lead shotshell pellets and bullets were indistinguishable. Thus, lead-contaminated meat from game harvested with lead bullets may also be contributing to the lead body burden.

  1. Teleconnection Locator: TeleLoc

    Science.gov (United States)

    Bowen, M. K.; Duffy, D.

    2016-12-01

    Extreme climate events, such as tropical storms, droughts, and floods, have an enormous impact on all aspects of society. Being able to detect the causes of such events on a global scale is paramount to being able to predict when and where these events will occur. These teleconnections, where a small change in a closed, complex system creates drastic disturbances elsewhere in the system, are generally represented by an index, one of the most famous being the El Nino Southern Oscillation (ENSO). However, due to the enormity, complexity, and technical challenges surrounding climate and its data, it is hypothesized that many of these teleconnections have as of yet gone undiscovered. TeleLoc (Teleconnection Locator) is a machine-learning framework combining a number of techniques for finding correlations between weather trends and extreme climate events. The current focus is on connecting global trends with tropical cyclones. A combination of two data sets, The International Best Track Archive for Climate Stewardship (IBTrACS) and the Modern-Era Retrospective analysis for Research and Applications (MERRA2), are being utilized. PostGIS is used for raw data storage, and a Python API has been developed as the core of the framework. Cyclones are first clustered using a combination of Symbolic Aggregate ApproXimation (this allows for a symbolic, sequential representation of the various time-series variables of interest) and DBSCAN. This serves to break the events into subcategories, which alleviates computational load for the next step. Events which are clustered together (those with similar characteristics) are compared against global climate variables of interest, which are also converted to a symbolic form, leading up to the event using Association Rule Mining. Results will be shown where cyclones have been clustered, specifically in the West Pacific storm basin, as well as the global variable symbolic subsections with a high support that have been singled out for

  2. Location Systems An Introduction to the Technology Behind Location Awareness

    CERN Document Server

    LaMarca, Anthony

    2008-01-01

    Advances in electronic location technology and the coming of age of mobile computing have opened the door for location-aware applications to permeate all aspects of everyday life. Location is at the core of a large number of high-value applications ranging from the life-and-death context of emergency response to serendipitous social meet-ups. For example, the market for GPS products and services alone is expected to grow to US200 billion by 2015. Unfortunately, there is no single location technology that is good for every situation and exhibits high accuracy, low cost, and universal coverage.

  3. CADUCEUS, SCIPIO, ALCADIA: Cell therapy trials using cardiac-°©‐derived cells for patients with post myocardial infarction LV dysfunction, still evolving

    Directory of Open Access Journals (Sweden)

    Magdi H Yacoub

    2012-03-01

    Full Text Available The early results of the CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction study were recently published in the Lancet [1]. This study is a phase 1 prospective randomised study, performed at two centres. The study was designed to test the hypothesis that intracoronary infusion of autologous cardiac-derived cells following myocardial infarction can reduce the size of the infarct and increase the amount of viable myocardium. The eligible patients were randomised in a 2:1 ratio to receive CDCs or standard care. In all, 17 patients were randomised to cell therapy and 8 to standard care. The cell therapy consisted of an infusion of 25 million cells into the infarct related artery, 1.5–3 months after successful primary angioplasty in patients who developed LV dysfunction (EF less than 37 per cent. The cells were derived from RV endomyocardial biopsies performed within the previous 37 days. The number of cells was determined from previous experimental studies of the maximum number of cells which can be injected without inducing infarction. The study was not blinded because of ethical considerations regarding performing right ventricular biopsy on the controls. The exclusion criteria included patients who had evidence of right ventricular infarction, or could not have an MRI examination because of claustrophobia or prior insertion of devices. There was no death, myocardial infarction or serious arrhythmia reported in either group during the period of follow up, which was between 6-12 months. Serious adverse events were observed in 24 percent of the intervention group versus 12 per cent in the controls (p not significant.

  4. MFL-P Chemotherapy for Pretreated Metastatic Breast Cancer Patients: A Regimen with Triple Biochemical Modulation by MTX-5FU, LV-5FU and 5FU-CDDP.

    Science.gov (United States)

    Kan; Honda

    1999-07-25

    BACKGROUND: Chemotherapeutic regimens, such as cyclophosphamide + doxorubicin + 5FU (CAF) or cyclophosphamide + methotrexate + 5FU (CMF), are sometimes used in combination with endocrine or radiotherapy as a standard first line of treatment for recurrent or metastatic breast cancer. However, many cases are, or become, refractory to these treatments. METHODS: Twenty-one women with recurrent or metastatic breast cancer who previously underwent treatment were administered our original regimen of combinationchemotherapy, MFL-P: Day 1, bolus methotrexate (MTX) 50 mg/body (median dose, 33 mg/m(2); range, 29-35 mg/m(2)) and 4 hours later 5-fluorouracil (5FU) 750 mg/body/h (median dose, 497 mg/m(2)/h; range, 441-528 mg/m(2) /h); Days 2-3, bolus leucovorin(LV) 15 mg/body every 8 h x 3; Days 2-5, 72 hours continuous 5FU 750 mg/body/24h; Day 6, cisplatin (CDDP) 50 mg/body/h (median dose, 33 mg/m(2)/h; range, 29-35 mg/m(2) /h) with sufficient hydration. The subjects ranged in age from 26 to 63 years (mean age, 51.3 years). RESULTS: One complete and 9 partial responses were achieved among the 20 patients (response rate, 50%). In 1 patient, diffuse liver metastasis was not measurable. Among various metastatic sites, a higher response rate was observed especially for soft tissue lesions (skin, chest wall and lymph nodes; 9 responders among 11 lesions). On the other hand, in visceral or skeletal metastases, the response rate was poor. The adverse effects were tolerable in all patients, except for common low-grade stomatitis or anorexia. CONCLUSION: MFL-P is useful as a second or third line of therapy for patients with refractory, recurrent or metastatic breast cancer with soft tissues lesions.

  5. Hospitalization rates and associated cost analysis of cardiac resynchronization therapy with an implantable defibrillator and quadripolar vs. bipolar left ventricular leads: a comparative effectiveness study.

    Science.gov (United States)

    Forleo, Giovanni B; Di Biase, Luigi; Bharmi, Rupinder; Dalal, Nirav; Panattoni, Germana; Pollastrelli, Annalisa; Tesauro, Manfredi; Santini, Luca; Natale, Andrea; Romeo, Francesco

    2015-01-01

    This study compares, from a prospective, observational, non-randomized registry, the post-implant hospitalization rates and associated healthcare resource utilization of cardiac resynchronization therapy-defibrillator (CRT-D) patients with quadripolar (QUAD) vs. bipolar (BIP) left ventricular (LV) leads. Between January 2009 and December 2012, 193 consecutive patients receiving de novo CRT-D implants with either a QUAD (n = 116) or a BIP (n = 77) LV lead were enrolled at implant and followed until July 2013 at a single-centre, university hospital. Post-implant hospitalizations related to heart failure (HF) or LV lead surgical revision and associated payer costs were identified using ICD-9-CM diagnosis and procedure codes. Italian national reimbursement rates were determined. Propensity scores were estimated using a logistic regression model based upon 11 pre-implant baseline characteristics and were used to derive a 1 : 1 matched cohort of QUAD (n = 77) and BIP (n = 77) patients. Hospitalization rates for the two groups were compared using negative binomial regression and associated payer costs were compared using non-parametric bootstrapping (×10 000) and one-sided hypothesis test. Hospitalization rates of the QUAD group [0.15/ patient (pt)-year] were lower than those of the BIP group (0.32/ pt-year); the incidence rate ratio was 0.46, P = 0.04. The hospitalization costs for the QUAD group (434 ± 128 €/pt-year) were lower than those for the BIP group (1136 ± 362 €/pt-year). The average difference was 718 €/pt-year, P = 0.016. In this comparative effectiveness assessment of well-matched groups of CRT-D patients with quadripolar and bipolar LV leads, QUAD patients experienced a lower rate of hospitalizations for HF and LV lead surgical revision, and a lower cost burden. This has important implications for LV pacing lead choice. © The Author 2014. Published by Oxford University Press on behalf of the European Society of Cardiology.

  6. Relationship between soil lead and airborne lead concentrations at Springfield, Missouri, USA

    Energy Technology Data Exchange (ETDEWEB)

    Sheets, R.W.; Kyger, J.R.; Biagioni, R.N.; Probst, S. [Department of Chemistry, Southwest Missouri State University, 65804 Springfield, MO (United States); Boyer, R.; Barke, K. [Greene County Health Department, 65802 Springfield, MO (United States)

    2001-04-23

    This study tests whether lead deposited to soil from automobiles during past years in a medium-sized US city (population 150000) may present a current health risk. It examines the relationship between current soil lead concentrations at nine locations within the city of Springfield, Missouri, and airborne lead levels measured at the same locations during years (1975-1981) when lead emissions from automobiles were much greater than at present. A strong, significant correlation is found between soil and airborne lead levels at eight of the sites (r=0.91, P<0.005 for soil lead vs. 1979 airborne lead), in low-traffic areas as well as in areas adjacent to heavy traffic flow. Residual lead concentrations in these soils are relatively low, even for the high-traffic sites, as expected for a medium sized city.

  7. Cryogenic current leads

    Energy Technology Data Exchange (ETDEWEB)

    Zizek, F.

    1982-01-01

    Theoretical, technical and design questions are examined of cryogenic current leads for SP of magnetic systems. Simplified mathematical models are presented for the current leads. To illustrate modeling, the calculation is made of the real current leads for 500 A and three variants of current leads for 1500 A for the enterprise ''Shkoda.''

  8. Learn about Lead

    Science.gov (United States)

    ... old and younger are most susceptible to the effects of lead. Children Even low levels of lead in the blood ... simple blood test to check you or your child for lead exposure. You may also want to test your home for sources ... and Technology Lead Laws and Regulations Outreach and Grants En ...

  9. Alterações clínicas e hematológicas em gatos domésticos naturalmente infectados pelo Vírus da Leucemia Felina (FeLV

    Directory of Open Access Journals (Sweden)

    Nádia Rossi de Almeida

    2016-07-01

    Full Text Available O Vírus da Leucemia Felina (FeLV é um retrovírus imunossupressor e o maior causador de morte dentre as doenças infecciosas felinas. O FeLV induz ao desenvolvimento de distúrbios degenerativos e/ou mieloproliferativos nos animais infectados, que sucumbem à infecções oportunistas devido à imunossupressão. As alterações nos parâmetros hematológicos em gatos FeLV positivos muitas vezes não condizem com o estado clínico do animal, podendo o mesmo ser um portador assintomático apresentando alterações hematológicas, ou sintomático sem alterações nestes parâmetros. O objetivo do presente estudo foi avaliar as alterações nos parâmetros clínicos e hematológicos de gatos domésticos infectados naturalmente pelo FeLV, nas fases sintomáticas e assintomáticas da doença. Desta forma, foram selecionados 40 gatos domiciliados previamente testados como positivos para o FeLV pela técnica de imunofluorescência indireta. O exame físico foi realizado e os animais foram separados em dois grupos: os gatos sintomáticos e os assintomáticos para a infecção. Amostras de sangue para a realização de hemograma foram coletadas de ambos os grupos e o teste estatístico ANOVA foi realizado para a comparação das alterações hematológicas. O exame clínico indicou 37,5% dos gatos como portadores assintomáticos e 62,5% sintomáticos, sendo a perda de peso e alterações de mucosas os achados mais frequentes. O hemograma evidenciou anemia e linfopenia como os parâmetros hematológicos que apresentaram diferenças estatísticas entre os dois grupos estudados, sendo que 56% dos gatos assintomáticos apresentaram anemia. Em face aos resultados encontrados, concluiu-se que gatos FeLV positivos sintomáticos apresentaram alterações hematológicas condizentes com o quadro de imunossupressão clínico.

  10. WHERE2 Location Aided Communications

    DEFF Research Database (Denmark)

    Dammann, Armin; Agapiou, George; Brunel, Loïc

    2013-01-01

    This paper presents an overview of preliminary results of investigations within the WHERE2 Project on identifying promising avenues for location aided enhancements to wireless communication systems. The wide ranging contributions are organized according to the following targeted systems: cellular......(s). And this at a reasonable cost given the ubiquitous availability of location information in recent wireless standards or smart phones. Location tracking furthermore opens the new perspective of slow fading prediction....

  11. TOA-BASED ROBUST LOCATION ALGORITHMS FOR WIRELESS CELLULAR NETWORKS

    Institute of Scientific and Technical Information of China (English)

    Sun Guolin; Guo Wei

    2005-01-01

    Caused by Non-Line-Of-Sight (NLOS) propagation effect, the non-symmetric contamination of measured Time Of Arrival (TOA) data leads to high inaccuracies of the conventional TOA based mobile location techniques. Robust position estimation method based on bootstrapping M-estimation and Huber estimator are proposed to mitigate the effects of NLOS propagation on the location error. Simulation results show the improvement over traditional Least-Square (LS)algorithm on location accuracy under different channel environments.

  12. A-type CpG ODN with higher binding affinity to LvToll1 could probably activate downstream IFN system-like antiviral response in shrimp Litopenaeus vannamei

    Directory of Open Access Journals (Sweden)

    J Xu

    2016-12-01

    Full Text Available CpG oligodeoxynucleotides (CpG ODNs is a widely used immune adjuvant, which could activate various immune responses including antiviral response through interaction with Toll-like receptor 9 (TLR9 in mammals. In the present study, four types of CpG ODN (CpG-A, CpG-B CpG-C, and CpG-P were synthesized and injected to the shrimp Litopenaeus vannamei in order to evaluate their immune enhancement effect in shrimp. The copy numbers of white spot syndrome virus in the shrimps treated with different types of CpG ODNs were of 3.10×105 (CpG-A, 8.32×105 (CpG-B, 9.84×105 (CpG-C, and 8.12×105 (CpG-P copies ng-1 DNA respectively, which were significantly lower (p < 0.01 than that in PBS group (1.70×106 copies ng-1 DNA. Surface plasmon resonance (SPR assay revealed that the four types of CpG ODN displayed different binding affinity to LvToll1, LvToll2 and LvToll3, and the highest binding affinity was observed between CpG-A and LvToll1. Correspondingly, the mRNA transcripts of LvTolls were up-regulated significantly in CpG-A stimulated shrimps,which was significantly higher than that in CpG-B, CpG-C and CpG-P groups (p < 0.01. The phagocytic rate and ROS level of shrimp hemocytes in CpG-A and CpG-B groups increased significantly compared with that in other groups, which were 1.63-fold, 9.98-fold (p < 0.01 in CpG-A and 1.60-fold, 4.92-fold (p < 0.01 in CpG-B higher than those in PBS group, respectively. Moreover, after CpG-A stimulation, the probable IFN level in shrimp plasma increased to 2.60-fold (p < 0.01 of that in PBS group, and the mRNA expressions of IFN system-like antiviral genes (LvIRF, LvVago4 and LvSTAT were also significantly up-regulated in CpG-A group, displaying a stronger response than that in CpG-B, CpG-C and CpG-P groups. The results indicated that CpG-A could promote the cellular and humoral immunity in shrimp, and induce relatively higher antiviral immune response among the four CpG ODNs. It provided useful information to understand

  13. Lead in water sources and lead and organochlorines in supplemental food items for the California condor

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — All but one water sample had lead concentrations below the detection limit (Table 1). The water sample collected from Ventucopa, located in Santa Barbara County, had...

  14. Family ties and residential locations

    NARCIS (Netherlands)

    Mulder, C.H.; Cooke, T.J.

    2009-01-01

    In this paper, and in the Special Issue it introduces, the focus is on the role of family ties in residential location choice and, conversely, the role of residential locations in maintaining family ties. Not only do events in the nuclear family trigger residential relocations, but nearby family mem

  15. Improved Dynamic Planar Point Location

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Arge, Lars; Georgiadis, Loukas

    2006-01-01

    We develop the first linear-space data structures for dynamic planar point location in general subdivisions that achieve logarithmic query time and poly-logarithmic update time.......We develop the first linear-space data structures for dynamic planar point location in general subdivisions that achieve logarithmic query time and poly-logarithmic update time....

  16. Pan-information Location Map

    Science.gov (United States)

    Zhu, X. Y.; Guo, W.; Huang, L.; Hu, T.; Gao, W. X.

    2013-11-01

    A huge amount of information, including geographic, environmental, socio-economic, personal and social network information, has been generated from diverse sources. Most of this information exists separately and is disorderly even if some of it is about the same person, feature, phenomenon or event. Users generally need to collect related information from different sources and then utilize them in applications. An automatic mechanism, therefore, for establishing a connection between potentially-related information will profoundly expand the usefulness of this huge body of information. A connection tie is semantic location describing semantically concepts and attributes of locations as well as relationships between locations, since 80% of information contains some kind of geographic reference but not all of geographic reference has explicit geographic coordinates. Semantic location is an orthogonal form of location representation which can be represented as domain ontology or UML format. Semantic location associates various kinds of information about a same object to provide timely information services according to users' demands, habits, preferences and applications. Based on this idea, a Pan-Information Location Map (PILM) is proposed as a new-style 4D map to associates semantic location-based information dynamically to organize and consolidate the locality and characteristics of corresponding features and events, and delivers on-demand information with a User-Adaptive Smart Display (UASD).

  17. RESEARCH METHODS OF LOCATIVE ELEMENT

    Directory of Open Access Journals (Sweden)

    SULAYMANOVA N.J.

    2012-01-01

    Full Text Available The article is devoted to the methods of investigation of locative elements. Sentence analysis with locative elements is taken according to the results of component analysis in the system of contradicting – opposition. More over the article is full of examples related to the description of various syntactic units.

  18. Neural correlates of locative prepositions

    NARCIS (Netherlands)

    Noordzij, Matthijs L.; Neggers, Sebastiaan F.W.; Ramsey, Nick F.; Postma, Albert

    2008-01-01

    Locative prepositions might be special linguistic modifiers because they form a natural link between verbal and visual-spatial information. In the present fMRI study we found evidence that understanding categorical spatial relations expressed in language with locative prepositions such as “to the le

  19. Locative Terms and Warlpiri Acquisition.

    Science.gov (United States)

    Bavin, Edith L.

    1990-01-01

    Focuses on the influence of language specific properties in the acquisition of locative expressions. Some of the claims from literature on the acquisition of locative expressions are discussed and data from the acquisition of Warlpiri are presented and discussed in terms of these claims. (Author/CB)

  20. Neural correlates of locative prepositions

    NARCIS (Netherlands)

    Noordzij, Matthijs Leendert; Neggers, Sebastiaan F.W.; Ramsey, Nick F.; Postma, Albert

    2008-01-01

    Locative prepositions might be special linguistic modifiers because they form a natural link between verbal and visual-spatial information. In the present fMRI study we found evidence that understanding categorical spatial relations expressed in language with locative prepositions such as “to the

  1. Mobile Alternative Fueling Station Locator

    Energy Technology Data Exchange (ETDEWEB)

    2009-04-01

    The Department of Energy's Alternative Fueling Station Locator is available on-the-go via cell phones, BlackBerrys, or other personal handheld devices. The mobile locator allows users to find the five closest biodiesel, electricity, E85, hydrogen, natural gas, and propane fueling sites using Google technology.

  2. A Decision Framework for Location Selection in Thailand: A Case Study in Hard Disk Drive Manufacturing Facility Location

    OpenAIRE

    Bhumipipatana, Kanitsaran

    2010-01-01

    ABSTRACT Making location selection for the operation of products is a complex decision-making process for manufacturing firms since the optimal location could enhance the firms’ competitive advantage and lead to a success in business. In this study, the critical factors affecting foreign firms’ international location decision are explored and aggregated into a comprehensive set of main factors and sub-factors. The results are examined by looking at the group sample of the Hard Disk Drive ...

  3. A COLLABORATIVE LOCATION MODEL FOR CELLULAR MOBILE POSITION LOCATION

    Institute of Scientific and Technical Information of China (English)

    Deng Ping; Liu Lin; Fan Pingzhi

    2004-01-01

    In cellular network, several Time Difference Of Arrival (TDOA) location algorithms can be applied to mobile position estimation. However, each algorithm has its own limitations and none of them is proved to be the most reliable one in different channel environments. In this paper Kleine-Ostmann's data fusion model is modified and a collaborative location model which incorporates position estimate of two TDOA location algorithms is proposed.Analysis and simulation show that more reliable and accurate mobile position estimation can be achieved based on this model.

  4. Modeling discrete competitive facility location

    CERN Document Server

    Karakitsiou, Athanasia

    2015-01-01

    This book presents an up-to-date review of modeling and optimization approaches for location problems along with a new bi-level programming methodology which captures the effect of competition of both producers and customers on facility location decisions. While many optimization approaches simplify location problems by assuming decision making in isolation, this monograph focuses on models which take into account the competitive environment in which such decisions are made. New insights in modeling, algorithmic and theoretical possibilities are opened by this approach and new applications are possible. Competition on equal term plus competition between market leader and followers are considered in this study, consequently bi-level optimization methodology is emphasized and further developed. This book provides insights regarding modeling complexity and algorithmic approaches to discrete competitive location problems. In traditional location modeling, assignment of customer demands to supply sources are made ...

  5. Uncapacitated facility location problems: contributions

    Directory of Open Access Journals (Sweden)

    Galvão Roberto Diéguez

    2004-01-01

    Full Text Available The objective of the present paper is to review my personal contributions in the field of uncapacitated facility location problems. These contributions took place throughout my academic career, from the time I was a Ph.D. student at Imperial College to the present day. They cover approximately 30 years, from 1973 to 2003; they address: algorithms developed for the p-median problem and for a general formulation of uncapacitated location problems; the study of dynamic location models; covering and hierarchical location problems; queuing-based probabilistic location models. The contributions encompass theoretical developments, computational algorithms and practical applications. All work took place in an academic environment, with the invaluable collaboration of colleagues (both in Brazil and abroad and research students at COPPE. Each section in the paper is dedicated to a topic that involves a personal contribution. Every one of them is placed within the context of the existing literature.

  6. Lead and tap water

    Science.gov (United States)

    Water contaminated with lead ... The Environmental Protection Agency (EPA) monitors drinking water in the United States. It requires water suppliers to produce annual water quality reports. These reports include information about lead amounts, and they ...

  7. Lead and Your Baby

    Science.gov (United States)

    ... who works with lead, like in auto repair, construction or in a plant that makes paint, batteries, ... who works with lead, like in auto repair, construction or in a plant that makes paint, batteries, ...

  8. Exposures to lead.

    Science.gov (United States)

    Callan, Anna C; Hinwood, Andrea L

    2011-01-01

    The Pacific Basin Consortium for Environment and Health hosted a workshop on Exposures to Lead. Speakers from Australia and the United States of America addressed current research knowledge on lead exposures and health effects in children, risk assessment and communication issues in dealing with lead exposure sources, different methods for assessing exposure, and the variety of scenarios where lead still remains a pollutant of concern. Mining continues to be a source of lead for many communities, and approaches to reducing exposures in these settings present particular challenges. A Perth Declaration for the Global Reduction of Childhood Lead Exposure was signed by participants of the meeting and is aimed at increasing attention to the need to continue to assess lead in the environment and to develop strategies to reduce lead in the environment and exposure by communities.

  9. Rapid Lead Screening Test

    Science.gov (United States)

    ... Vitro Diagnostics Tests Used In Clinical Care Rapid Lead Screening Test Share Tweet Linkedin Pin it More ... reducing the need for a follow-up visit. Lead Risk Links Centers for Disease Control and Prevention ( ...

  10. Lead Poisoning (For Parents)

    Science.gov (United States)

    ... organs and tissues that need it, thus causing anemia. Most lead ends up in the bone, where it causes ... vomiting or nausea constipation pallor (pale skin) from ... look for lead poisoning or other health problems. Treatment Treatment for ...

  11. NA49: lead-lead collision

    CERN Multimedia

    1996-01-01

    This is an image of an actual lead ion collision taken from tracking detectors on the NA49 experiment, part of the heavy ion project at CERN. These collisions produce a very complicated array of hadrons as the heavy ions break up. It is hoped that one of these collisions will eventually create a new state of matter known as quark-gluon plasma.

  12. Occupational lead poisoning

    OpenAIRE

    Ramírez, Augusto V; Médico del Trabajo. American College of Occupational and Environmental Medicine.

    2013-01-01

    Lead, a ubiquitous heavy metal, has been found in places as unlikely as Greenland’s fossil ice. Egyptians and Hebrews used it. In Spain, Phoenicians c. 2000 BC worked ores of lead. At the end of the XX century, occupational lead’s poisoning became a public health problem in developed countries. In non-developed countries occupational lead poisoning is still frequent. Diagnosis is directed to recognize lead existence at the labor environment and good clinical and occupational documentation. Di...

  13. Application of a fast and efficient algorithm to detect areas with prerequisites for landslide in sensitive clays, Göta Älv, Sweden

    Science.gov (United States)

    Melchiorre, Caterina; Tryggvason, Ari

    2014-05-01

    In Sweden, landslide stability maps are based on the recognition of topographical and soil conditions. The topographical criterion is based on the ratio between height of the slope and its length. The calculation of this cross-sectional angle is straight forward in one dimension, but slightly more complicated in two dimensions and very computationally expensive in a GIS environment. We present an application of a fast and efficient computer algorithm based on slope and soil criteria in Göta Älv, southwest Sweden. The algorithm, compared to other software implementations of the cross-sectional angle criterion, guarantees a fast execution, the possibility to insert several threshold values of the cross-sectional angle and the use of information on bedrock elevation. As input maps we used a 1:50000 Quaternary soil map, a DEM at 2x2 m pixel resolution, and a bedrock elevation map. We used two sets of cross-sectional angle thresholds, the first one derived from stability calculation and the second one assessed through the relationship between QCSI (i.e., estimated value of the sensitivity) and the cross-sectional angle calculated from the landslide scar database. A comparison between the results of the algorithm using or not using the bedrock information was also performed. The produced maps were validated by using the landslide scar database and a hazard map. The results show that the use of bedrock information decreases the calculated areas with prerequisites for landslides, whereas not decreasing the performance of the algorithm. The maps produced by using the two different sets of cross-angle thresholds are very similar and show similar results in the validation. This means that it would be possible to extent this methodology in areas without geotechnical information by using less expensive data such as the QCSI. Moreover, the use of several cross-sectional angle thresholds is not possible in other software implementations available at the moment. This means that

  14. Light location influences the perceived locations of internal sounds.

    Science.gov (United States)

    Dellorso, Scott; Schirillo, James

    2010-01-01

    Numerous studies have shown that visual stimuli can bias the perceived location of auditory stimuli. Here, we sought to determine if a visual stimulus can also bias the perceived location of multiple internal auditory stimuli. Fifty subjects were presented with a train of eight binaural click-pairs over headphones while a single flash of light was presented either to the left or to the right side of a central fixation point on an otherwise black CRT screen. A no-flash baseline was also implemented, as was a no-fixation control. The subjects used a rating scale to indicate the perceived location of each of the eight click-pairs within their heads. The results showed that the flash of light significantly influenced the perceived location of the click-pairs, biasing them in the same direction as the flash of light. This suggests that, even without perceptual correspondence, cross-modal interactions can occur.

  15. Lead Poisoning in Children.

    Science.gov (United States)

    Drummond, A. H., Jr.

    1981-01-01

    Early symptoms of lead poisoning in children are often overlooked. Lead poisoning has its greatest effects on the brain and nervous system. The obvious long-term solution to the lead poisoning problem is removal of harmful forms of the metal from the environment. (JN)

  16. Atrioventricular Pacemaker Lead Reversal

    Directory of Open Access Journals (Sweden)

    Mehmet K Aktas, MD

    2007-01-01

    Full Text Available During cardiac surgery temporary epicardial atrial and ventricular leads are placed in case cardiac pacing is required postoperatively. We present the first reported series of patients with reversal of atrioventricular electrodes in the temporary pacemaker without any consequent deleterious hemodynamic effect. We review the electrocardiographic findings and discuss the findings that lead to the discovery of atrioventricular lead reversal.

  17. Locating Depots for Capacitated Vehicle Routing

    CERN Document Server

    Goertz, Inge Li

    2011-01-01

    We study a location-routing problem in the context of capacitated vehicle routing. The input is a set of demand locations in a metric space and a fleet of k vehicles each of capacity Q. The objective is to locate k depots, one for each vehicle, and compute routes for the vehicles so that all demands are satisfied and the total cost is minimized. Our main result is a constant-factor approximation algorithm for this problem. To achieve this result, we reduce to the k-median-forest problem, which generalizes both k-median and minimum spanning tree, and which might be of independent interest. We give a (3+c)-approximation algorithm for k-median-forest, which leads to a (12+c)-approximation algorithm for the above location-routing problem, for any constant c>0. The algorithm for k-median-forest is just t-swap local search, and we prove that it has locality gap 3+2/t; this generalizes the corresponding result known for k-median. Finally we consider the "non-uniform" k-median-forest problem which has different cost ...

  18. Locations in television drama series

    DEFF Research Database (Denmark)

    Waade, Anne Marit

    , and reflect the growing academic and business interests, respectively, on places in a global media and consumption culture (Falkheimer & Jansson, 2006). Based on empirical location studies of three crime series, Wallander (Yellow Bird, 2008-2012), The Bridge (SVT1 & DR1, 2011-2013) and Dicte (Misofilm/TV2...... in the extra bonus material (Gray, 2010; Waade, 2013), and film tours and film apps become part of the television series’ trans-media franchise (Reijnders, 2011; Thompson, 2007). Location has so far been a practical term describing the place where the series is shot. Ellis (1992) used to see location...

  19. Location Based Services and Applications

    Directory of Open Access Journals (Sweden)

    Elenis Gorrita Michel

    2012-05-01

    Full Text Available Location Based Services (LBS continue to grow in popularity, effectiveness and reliability, to the extent that applications are designed and implemented taking into account the facilities of the user location information. In this work, some of the main applications are addressed, in order to make an assessment of the current importance of the LBS, as a branch of technology in full swing. In addition, the main techniques for location estimation are studied, essential information to the LBS. Because of this it is a highly topical issue, the ongoing works and researches are also discussed.

  20. ALICE: Simulated lead-lead collision

    CERN Multimedia

    2003-01-01

    This track is an example of simulated data modelled for the ALICE detector on the Large Hadron Collider (LHC) at CERN, which will begin taking data in 2008. ALICE will focus on the study of collisions between nuclei of lead, a heavy element that produces many different particles when collided. It is hoped that these collisions will produce a new state of matter known as the quark-gluon plasma, which existed billionths of a second after the Big Bang.

  1. CBP List of Preclearance Locations

    Data.gov (United States)

    Department of Homeland Security — CBP Preclearance provides for the U.S. border inspection and clearance of commercial air passengers and their goods at (15) locations in (6) foreign countries. CBP...

  2. Mental Health Treatement Facilities Locator

    Data.gov (United States)

    U.S. Department of Health & Human Services — An online resource for locating mental health treatment facilities and programs supported by the Substance Abuse and Mental Health Services Administration (SAMHSA)....

  3. Allegheny County WIC Vendor Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset contains the locations of Women, Infants, and Children (WIC) program vendors. If viewing this description on the Western Pennsylvania Regional Data...

  4. Allegheny County Blazed Trails Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Shows the location of blazed trails in all Allegheny County parks. This is the same data used in the Allegheny County Parks Trails Mobile App, available for Apple...

  5. NIGERIA - A TROPICAL COASTAL LOCATION

    African Journals Online (AJOL)

    2008-02-21

    Feb 21, 2008 ... “Department of Physics, University of Calabar, Calabar, Nigeria ... The characteristic pattern of rainfall in Calabar, a coastal - tropical location ... percentiles over most of Australia for ... meteorological records of the Margaret.

  6. VT School Locations - K-12

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) FacilitiesSchools_PTSCHOOL is designed to provide point locations of every Vermont School along with the established school ID (PSID) for...

  7. Locative inferences in medical texts.

    Science.gov (United States)

    Mayer, P S; Bailey, G H; Mayer, R J; Hillis, A; Dvoracek, J E

    1987-06-01

    Medical research relies on epidemiological studies conducted on a large set of clinical records that have been collected from physicians recording individual patient observations. These clinical records are recorded for the purpose of individual care of the patient with little consideration for their use by a biostatistician interested in studying a disease over a large population. Natural language processing of clinical records for epidemiological studies must deal with temporal, locative, and conceptual issues. This makes text understanding and data extraction of clinical records an excellent area for applied research. While much has been done in making temporal or conceptual inferences in medical texts, parallel work in locative inferences has not been done. This paper examines the locative inferences as well as the integration of temporal, locative, and conceptual issues in the clinical record understanding domain by presenting an application that utilizes two key concepts in its parsing strategy--a knowledge-based parsing strategy and a minimal lexicon.

  8. Neural correlates of locative prepositions.

    Science.gov (United States)

    Noordzij, Matthijs L; Neggers, Sebastiaan F W; Ramsey, Nick F; Postma, Albert

    2008-04-01

    Locative prepositions might be special linguistic modifiers because they form a natural link between verbal and visual-spatial information. In the present fMRI study we found evidence that understanding categorical spatial relations expressed in language with locative prepositions such as "to the left of" and "to the right of" were reliably associated with cerebral activity in the supramarginal gyrus (SMG) located in the left inferior parietal lobe. The higher activity associated with spatial as compared to non-spatial sentences in this region was not dependent on the context (verbal or visual-spatial) in which the sentence was read. Therefore, the function of this activity appears to be to create a general, amodal representation of locative prepositions that allow for flexible comparisons to either verbal or visual-spatial material.

  9. Allegheny County Public Building Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset contains the locations of municipal facilities in Allegheny County. If viewing this description on the Western Pennsylvania Regional Data Center’s...

  10. Allegheny County Public Building Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset contains the locations of municipal facilities in Allegheny County. If viewing this description on the Western Pennsylvania Regional Data Center’s open...

  11. Substance Abuse Treatment Facilities Locator

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Substance Abuse and Mental Health Services Administration (SAMHSA) provides on-line resource for locating drug and alcohol abuse treatment programs. The...

  12. Allegheny County WIC Vendor Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset contains the locations of Women, Infants, and Children (WIC) program vendors. If viewing this description on the Western Pennsylvania Regional Data...

  13. Allegheny County Blazed Trails Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Shows the location of blazed trails in all Allegheny County parks. This is the same data used in the Allegheny County Parks Trails Mobile App, available for Apple...

  14. Hull properties in location problems

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1983-01-01

    Some properties of the solution set for single and multifacility continuous location problems with lp distances are given. A set reduction algorithm is developed for problems in k-dimensional space having rectangular distances.......Some properties of the solution set for single and multifacility continuous location problems with lp distances are given. A set reduction algorithm is developed for problems in k-dimensional space having rectangular distances....

  15. WHERE2 Location Aided Communications

    DEFF Research Database (Denmark)

    Dammann, Armin; Agapiou, George; Brunel, Loïc

    2013-01-01

    networks, mobile ad hoc networks (MANETs) and cognitive radio. Location based approaches are found to allevi- ate significant signaling overhead in various forms of modern communication paradigms that are very information hungry in terms of channel state information at the transmitter......This paper presents an overview of preliminary results of investigations within the WHERE2 Project on identifying promising avenues for location aided enhancements to wireless communication systems. The wide ranging contributions are organized according to the following targeted systems: cellular...

  16. A Calculus of Located Entities

    Directory of Open Access Journals (Sweden)

    Adriana Compagnoni

    2014-03-01

    Full Text Available We define BioScapeL, a stochastic pi-calculus in 3D-space. A novel aspect of BioScapeL is that entities have programmable locations. The programmer can specify a particular location where to place an entity, or a location relative to the current location of the entity. The motivation for the extension comes from the need to describe the evolution of populations of biochemical species in space, while keeping a sufficiently high level description, so that phenomena like diffusion, collision, and confinement can remain part of the semantics of the calculus. Combined with the random diffusion movement inherited from BioScape, programmable locations allow us to capture the assemblies of configurations of polymers, oligomers, and complexes such as microtubules or actin filaments. Further new aspects of BioScapeL include random translation and scaling. Random translation is instrumental in describing the location of new entities relative to the old ones. For example, when a cell secretes a hydronium ion, the ion should be placed at a given distance from the originating cell, but in a random direction. Additionally, scaling allows us to capture at a high level events such as division and growth; for example, daughter cells after mitosis have half the size of the mother cell.

  17. Lead-Free Piezoelectrics

    CERN Document Server

    Nahm, Sahn

    2012-01-01

    Ecological restrictions in many parts of the world are demanding the elimination of Pb from all consumer items. At this moment in the piezoelectric ceramics industry, there is no issue of more importance than the transition to lead-free materials. The goal of Lead-Free Piezoelectrics is to provide a comprehensive overview of the fundamentals and developments in the field of lead-free materials and products to leading researchers in the world. The text presents chapters on demonstrated applications of the lead-free materials, which will allow readers to conceptualize the present possibilities and will be useful for both students and professionals conducting research on ferroelectrics, piezoelectrics, smart materials, lead-free materials, and a variety of applications including sensors, actuators, ultrasonic transducers and energy harvesters.

  18. Lead Poison Detection

    Science.gov (United States)

    1976-01-01

    With NASA contracts, Whittaker Corporations Space Science division has developed an electro-optical instrument to mass screen for lead poisoning. Device is portable and detects protoporphyrin in whole blood. Free corpuscular porphyrins occur as an early effect of lead ingestion. Also detects lead in urine used to confirm blood tests. Test is inexpensive and can be applied by relatively unskilled personnel. Similar Whittaker fluorometry device called "drug screen" can measure morphine and quinine in urine much faster and cheaper than other methods.

  19. In Heart Failure Patients with Left Bundle Branch Block Single Lead MultiSpot Left Ventricular Pacing Does Not Improve Acute Hemodynamic Response To Conventional Biventricular Pacing. A Multicenter Prospective, Interventional, Non-Randomized Study

    OpenAIRE

    Maciej Sterliński; Adam Sokal; Radosław Lenarczyk; Frederic Van Heuverswyn; Aldo Rinaldi, C.; Marc Vanderheyden; Vladimir Khalameizer; Darrel Francis; Joeri Heynens; Berthold Stegemann; Richard Cornelussen

    2016-01-01

    Introduction Recent efforts to increase CRT response by multiSPOT pacing (MSP) from multiple bipols on the same left ventricular lead are still inconclusive. Aim The Left Ventricular (LV) MultiSPOTpacing for CRT (iSPOT) study compared the acute hemodynamic response of MSP pacing by using 3 electrodes on a quadripolar lead compared with conventional biventricular pacing (BiV). Methods Patients with left bundle branch block (LBBB) underwent an acute hemodynamic study to determine the %change in...

  20. Locating the LCROSS Impact Craters

    Science.gov (United States)

    Marshall, William; Shirley, Mark; Moratto, Zachary; Colaprete, Anthony; Neumann, Gregory A.; Smith, David E.; Hensley, Scott; Wilson, Barbara; Slade, Martin; Kennedy, Brian; hide

    2012-01-01

    The Lunar CRater Observations and Sensing Satellite (LCROSS) mission impacted a spent Centaur rocket stage into a permanently shadowed region near the lunar south pole. The Sheperding Spacecraft (SSC) separated approx. 9 hours before impact and performed a small braking maneuver in order to observe the Centaur impact plume, looking for evidence of water and other volatiles, before impacting itself. This paper describes the registration of imagery of the LCROSS impact region from the mid- and near-infrared cameras onboard the SSC, as well as from the Goldstone radar. We compare the Centaur impact features, positively identified in the first two, and with a consistent feature in the third, which are interpreted as a 20 m diameter crater surrounded by a 160 m diameter ejecta region. The images are registered to Lunar Reconnaisance Orbiter (LRO) topographical data which allows determination of the impact location. This location is compared with the impact location derived from ground-based tracking and propagation of the spacecraft's trajectory and with locations derived from two hybrid imagery/trajectory methods. The four methods give a weighted average Centaur impact location of -84.6796 deg, -48.7093 deg, with a 1s uncertainty of 115 m along latitude, and 44 m along longitude, just 146 m from the target impact site. Meanwhile, the trajectory-derived SSC impact location is -84.719 deg, -49.61 deg, with a 1 alpha uncertainty of 3 m along the Earth vector and 75 m orthogonal to that, 766 m from the target location and 2.803 km south-west of the Centaur impact. We also detail the Centaur impact angle and SSC instrument pointing errors. Six high-level LCROSS mission requirements are shown to be met by wide margins. We hope that these results facilitate further analyses of the LCROSS experiment data and follow-up observations of the impact region

  1. On Constrained Facility Location Problems

    Institute of Scientific and Technical Information of China (English)

    Wei-Lin Li; Peng Zhang; Da-Ming Zhu

    2008-01-01

    Given m facilities each with an opening cost, n demands, and distance between every demand and facility,the Facility Location problem finds a solution which opens some facilities to connect every demand to an opened facility such that the total cost of the solution is minimized. The k-Facility Location problem further requires that the number of opened facilities is at most k, where k is a parameter given in the instance of the problem. We consider the Facility Location problems satisfying that for every demand the ratio of the longest distance to facilities and the shortest distance to facilities is at most w, where w is a predefined constant. Using the local search approach with scaling technique and error control technique, for any arbitrarily small constant ∈ > 0, we give a polynomial-time approximation algorithm for the ω-constrained Facility Location problem with approximation ratio 1 + √ω + 1 + ∈, which significantly improves the previous best known ratio (ω + 1)/α for some 1 ≤α≤ 2, and a polynomial-time approximation algorithm for the ω-constrained κ-Facility Location problem with approximation ratio ω + 1 + ∈. On the aspect of approximation hardness, we prove that unless NP (C) DTIME(nO(loglogn)), the ω-constrained Facility Location problem cannot be approximated within 1 + √ω-1,which slightly improves the previous best known hardness result 1.243 + 0.316 ln(ω - 1). The experimental results on the standard test instances of Facility Location problem show that our algorithm also has good performance in practice.

  2. 中低压直流配电系统的主动保护研究%Research on Active Protection for MV/LV DC Distribution System

    Institute of Scientific and Technical Information of China (English)

    吴鸣; 刘海涛; 陈文波; 苏剑; 季宇; 孙丽敬; 王丽

    2016-01-01

    Due to the vast access of distributed energies, the rapid growth of DC loads and the rapid development of power electronics, the DC distribution is more and more concerned, and DC power distribution system will become an important part of distribution network in the future. The protection in the DC distribution system is a core problem during rapid development of the DC distribution system, and the lucubration is urgent. Aiming at common faults such as short-circuit, ground, ring network, AC releasing into DC system and insulation decreasing fault in MV/LV DC distribution system, this paper analyzed faults characteristics and their developing process, and it proposed a power electronic protection strategy, effectively integrating the DC protection with the power electronic converters. The strategy can realize the protection and failure isolation based on the topology structure and the operation mechanism of the converter, the effective coordination between the protection action logic and control logic. And this paper expounded the applications and component of the DC active protection, analyzed the principle and method of the active protections, expounded the active ground fault protection and short-circuit fault protection, and came up with the fault mechanism and active solution method in the DC ring network and AC releasing into DC system network. At last validating through actual cases, the result shows that active protection can realize the rapid and accurate isolation of the faults in DC distribution system, and ensure the system run steadily and reliably.%分布式发电和储能的大量接入、直流负荷的快速增长、电力电子技术的迅速发展,使得直流配电越来越受关注.直流配电系统将会成为未来配电技术的一个重要组成部分.但直流配电保护是直流配电系统快速发展的一个关键问题,亟需深入研究.针对中低压直流配电网中常见的短路、接地、环网、交直流混接、绝缘

  3. Modeling of LV Distribution Network Based on Metering Data%基于量测数据的低压配电网精确建模

    Institute of Scientific and Technical Information of China (English)

    栾文鹏; 王兵; 周宁; 郭志民

    2015-01-01

    低压配电网的电力线路参数是对其进行潮流计算、线损分析、窃电监测等的基础,而目前对于这方面的研究并不多,主要是由于无法获得低压配电网的量测数据。文章研究了基于高级量测体系(advanced metering infrastructure,AMI)提供的量测数据计算低压配电网线路参数的方法,以达到对配电网络精确建模的目的。该方法是在已知配电网拓扑的前提下利用智能电表所采集到的电压、有功功率和无功功率数据,通过计算上游节点电压,搭建求解优化问题的模型,使时间序列内不同电表数据计算得到的上游节点电压方差最小,或计算得到的该点电压和该点测量电压的差值最小,从而得到配电网线路的阻抗参数,实现配电网络的精确建模。最后以包含17个电表节点和21条支路的实际配网算例验证了所提方法的有效性。%For a long time, due to various reasons, power utilities don’t have full or accurate mastering of information of LVdistribution network. This is one of the cases for distribution networkparameters.Accuratecircuit parameters of LVdistribution network are basis of power flow calculation, loss analysis andenergytheftdetection.Electricalparameters are important, but research on them is far from sufficient mainly because of absence of measured data inLVdistribution network.Implementation ofadvanced metering infrastructure (AMI)provides new ways for solving this problem. Thispaper researchesapproacheson accurateelectricalcircuit parameter calculation inLVdistribution networkusing smart meter measurements,so as toobtain accurate model ofLV distribution network.Provided distribution network topology is known, the method leverages a series of smart meter measurements at end nodes of distribution network, mainly voltage, active power and reactive power at customer sides. It calculates voltage of the most upstream node or source node in radial

  4. Comparing methods for Earthquake Location

    Science.gov (United States)

    Turkaya, Semih; Bodin, Thomas; Sylvander, Matthieu; Parroucau, Pierre; Manchuel, Kevin

    2017-04-01

    There are plenty of methods available for locating small magnitude point source earthquakes. However, it is known that these different approaches produce different results. For each approach, results also depend on a number of parameters which can be separated into two main branches: (1) parameters related to observations (number and distribution of for example) and (2) parameters related to the inversion process (velocity model, weighting parameters, initial location etc.). Currently, the results obtained from most of the location methods do not systematically include quantitative uncertainties. The effect of the selected parameters on location uncertainties is also poorly known. Understanding the importance of these different parameters and their effect on uncertainties is clearly required to better constrained knowledge on fault geometry, seismotectonic processes and at the end to improve seismic hazard assessment. In this work, realized in the frame of the SINAPS@ research program (http://www.institut-seism.fr/projets/sinaps/), we analyse the effect of different parameters on earthquakes location (e.g. type of phase, max. hypocentral separation etc.). We compare several codes available (Hypo71, HypoDD, NonLinLoc etc.) and determine their strengths and weaknesses in different cases by means of synthetic tests. The work, performed for the moment on synthetic data, is planned to be applied, in a second step, on data collected by the Midi-Pyrénées Observatory (OMP).

  5. Processing locational and orientational information.

    Science.gov (United States)

    Maki, R H; Maki, W S; Marsh, L G

    1977-09-01

    In choice reaction time (RT) tasks, college students verified the truth of displays expressing spatial relations between two objects. The relations werelocational (A is left of B) ororientational (A and B are horizontal). The objects were names of states in the United States, symbols, or letter arrays. The objects were memorized prior to the display (states and letters) or were presented as part of the display (symbols and letters). In the location tasks with both states and symbols, locatives were spatial (right, left, above, below) or compass (north, south, east, west). Distance between states was also varied. When location was judged, horizontally aligned stimuli resulted in slower responses than vertically aligned stimuli, independently of materials and locative set. Reaction time was inversely related to distance. When orientation was judged, responses to horizontal pairs of states were slower than responses to vertical pairs of states, responses to horizontal pairs of letters were faster than responses to vertical pairs, and RT did not depend upon the orientation of symbols. This pattern of results suggests that orientational judgments are influenced by type of materials and the entext to which the material has been encoded (i.e., memorized). Locational judgments reflect a potent source of difficulty not present in orientation tasks, namely, telling left from right. Alternative explanations of the right-left effect are discussed.

  6. Location and activity specific site-management for military locations

    NARCIS (Netherlands)

    Maring, L.; Hulst, M. van; Meuken, D.

    2009-01-01

    pace is limited in the Netherlands and military activities, that may cause nuisance or environmental hazards, should therefore be considered and evaluated during the use of military locations. The last few years TNO and Deltares have worked on a research program on environmental effects due to milit

  7. Spatial interaction models facility location using game theory

    CERN Document Server

    D'Amato, Egidio; Pardalos, Panos

    2017-01-01

    Facility location theory develops the idea of locating one or more facilities by optimizing suitable criteria such as minimizing transportation cost, or capturing the largest market share. The contributions in this book focus an approach to facility location theory through game theoretical tools highlighting situations where a location decision is faced by several decision makers and leading to a game theoretical framework in non-cooperative and cooperative methods. Models and methods regarding the facility location via game theory are explored and applications are illustrated through economics, engineering, and physics. Mathematicians, engineers, economists and computer scientists working in theory, applications and computational aspects of facility location problems using game theory will find this book useful.

  8. Scenarios catalog for the graphical console for analysis of severe accidents visualization of OEs, NAEs and calculation of source term of the NPP-LV; Catalogo de escenarios para la consola grafica para analisis de accidentes severos visualizacion de OEs, NAEs y calculo del termino fuente de la CLV

    Energy Technology Data Exchange (ETDEWEB)

    Sandoval V, S. [Instituto Nacional de Electricidad y Energias Limpias, Reforma 113, Col. Palmira, 62490 Cuernavaca, Morelos (Mexico); Mendoza R, M. E.; Tijerina S, F.; Garcia C, T., E-mail: manuel.mendoza@cfe.gob.mx [CFE, Central Nucleoelectrica Laguna Verde, Carretera Federal Cardel-Nautla Km 42.5, 91476 Municipio Alto Lucero, Veracruz (Mexico)

    2016-09-15

    A nuclear power plant is operated at all times within the design criteria of structures, systems and components, and according to the operation technical specifications. For different areas of work of a nuclear power plant is necessary to carry out practices in which is useful to have the prediction of the thermo-hydraulic and radiological progression of scenarios that imply exceeding that design bases, even reaching the damage of the fuel in different degree. During the exercises and drills of the External Plan of Emergency Response, the projection of doses is done to exercise the different tasks of the plan. To make the projection of doses is required to have the radiological source term of the scenario on which is practiced. Because of this, was identified the convenience of having a catalog of scenarios for which the radiological source term was calculated. In 2004, a first version of the catalog was produced for a power of 2027 MW, and in 2011 the catalog was updated for extended power conditions, 2317 MW. Both versions were made using the severe accident simulator MAAP-3B. That catalog consists of a form and an optical storage device. The form contains tables and figures in which the characteristics of the scenario to be practiced are searched and the electronic files of the corresponding radiological source term are located in the storage device. Due to the recent development of the graphical console for analysis of severe accidents, visualization of OEs, NAEs and calculation of the source term for the nuclear power plant of Laguna Verde (NPP-LV) CoGrAAS, the catalog printed was replaced by an electronic catalog for the CoGrAAS. The new catalog retains the philosophy of the previous catalog, constituted by a wide collection of scenarios that involve different circumstances and phenomena, that can be used to practice different tasks during training exercises or simulacrums, and combined with the following advantages: the scenario selection is made from an

  9. Locating the LCROSS Impact Craters

    CERN Document Server

    Marshall, William; Moratto, Zachary; Colaprete, Anthony; Neumann, Gregory; Smith, David; Hensley, Scott; Wilson, Barbara; Slade, Martin; Kennedy, Brian; Gurrola, Eric; Harcke, Leif; 10.1007/s11214-011-9765-0

    2011-01-01

    The Lunar CRater Observations and Sensing Satellite (LCROSS) mission impacted a spent Centaur rocket stage into a permanently shadowed region near the lunar south pole. The Sheperding Spacecraft (SSC) separated \\sim9 hours before impact and performed a small braking maneuver in order to observe the Centaur impact plume, looking for evidence of water and other volatiles, before impacting itself. This paper describes the registration of imagery of the LCROSS impact region from the mid- and near-infrared cameras onboard the SSC, as well as from the Goldstone radar. We compare the Centaur impact features, positively identified in the first two, and with a consistent feature in the third, which are interpreted as a 20 m diameter crater surrounded by a 160 m diameter ejecta region. The images are registered to Lunar Reconnaisance Orbiter (LRO) topographical data which allows determination of the impact location. This location is compared with the impact location derived from ground-based tracking and propagation of...

  10. Neuroanatomical correlates of locative prepositions.

    Science.gov (United States)

    Tranel, Daniel; Kemmerer, David

    2004-10-01

    Very little research has explored which neural systems may be important for retrieving the meanings of locative prepositions (e.g., in, on, around). To begin to address this knowledge gap, we conducted a lesion study in which we tested the hypothesis that processing the meanings of locative prepositions depends on neural structures in the left inferior prefrontal cortex and left inferior parietal cortex. Seventy-eight subjects with focal, stable lesions to various parts of the telencephalon and a comparison group of 60 normal participants were studied with tasks that require production, comprehension, and semantic analysis of locative prepositions. In support of our hypothesis, we found that in subjects with impaired knowledge of locative prepositions, the highest region of lesion overlap was in the left frontal operculum and the left supramarginal gyrus, and in the white matter subjacent to these two areas. In a second study, focused on six subjects who had pervasive defects for locative preposition knowledge, we confirmed that such defects were associated specifically with damage to the posterior left frontal operculum, white matter subjacent to this region, and white matter underneath the inferior parietal operculum. These subjects did not have basic impairments in spatial processing or working memory, and they had relatively well-preserved processing of conceptual knowledge for actions and various categories of concrete entities (e.g., persons, animals, tools). All six subjects, however, had defects in naming actions, and some of them also had defective naming of some categories of concrete entities. Overall, the findings converge nicely with recent results from functional imaging approaches, and with classic studies from the aphasia-based literature, and suggest that the left inferior prefrontal and left inferior parietal regions have crucial-albeit not exclusive-roles in processing knowledge associated with locative prepositions.

  11. Locating ATMs in Urban Areas

    Directory of Open Access Journals (Sweden)

    Mehdi MoradiTabar

    2013-08-01

    Full Text Available In recent years, the banks and financial institutions have considerably attempted to provide better and more varied services to the customers. These varied services may satisfy needs of differentgroup of customers. In this regard, the location of these services as well as their level of accessibility (access to these services is greatly important. The importance of these issues is well recognized by responsible managers of the financial firms. In other words, the managers accept the importance of these services and they know that the quality and location of these services significantly affect their success in the business. Therefore, bank managers sought scientific methods, which may facilitate the locating process for their services. How to select the most effective methods and how to use these methods in this regard depend on following factors: the customers' demands, local capacities and fair distribution of theservices, etc. The effective impact of these factors as well as the interactive relationship between them should also be noted in the application. This study is a descriptive kind of research, which is applicable in various areas. Library and environmental studies were used to conduct the study. Considering the parameters that considerably affect the level of acceptability of ATMs services and analyzing the importance of these parameters according to this criterion, the researchers tried to use multiple attribute decision-making model. a heuristic algorithm was used in the context of this approach. Then, the most appropriate locations around the optimal locations were introduced based on fuzzy concept as well as quantitative and qualitative factors, including the minimum cost and maximum coverage according to the customers’ demands. The case study was located in the 13th district of Tehran city.

  12. Locating Depots for Capacitated Vehicle Routing

    DEFF Research Database (Denmark)

    Gørtz, Inge Li; Nagarajan, Viswanath

    2011-01-01

    We study a location-routing problem in the context of capacitated vehicle routing. The input to k-LocVRP is a set of demand locations in a metric space and a fleet of k vehicles each of capacity Q. The objective is to locate k depots, one for each vehicle, and compute routes for the vehicles so...... that all demands are satisfied and the total cost is minimized. Our main result is a constant-factor approximation algorithm for k-LocVRP. To achieve this result, we reduce k-LocVRP to the following generalization of k median, which might be of independent interest. Given a metric (V, d), bound k...... median forest, which leads to a (12+E)-approximation algorithm for k-LocVRP, for any constant E > 0. The algorithm for k median forest is t-swap local search, and we prove that it has locality gap 3 + 2 t ; this generalizes the corresponding result for k median [3]. Finally we consider the k median...

  13. Lead toxicity: Current concerns

    Energy Technology Data Exchange (ETDEWEB)

    Goyer, R.A. (Univ. of Western Ontario, London (Canada))

    1993-04-01

    Over the 20-year period since the first issue of Environmental Health Perspectives was published, there has been considerable progress in the understanding of the potential toxicity of exposure to lead. Many of these advances have been reviewed in published symposia, conferences, and review papers in EHP. This brief review identifies major advances as well as a number of current concerns that present opportunities for prevention and intervention strategies. The major scientific advance has been the demonstration that blood lead (PbB) levels of 10-15 micrograms/dL in newborn and very young infants result in cognitive and behavioral deficits. Further support for this observation is being obtained by prospective or longitudinal studies presently in progress. The mechanism(s) for the central nervous system effects of lead is unclear but involve lead interactions within calcium-mediated intracellular messenger systems and neurotransmission. Effects of low-level lead exposure on blood pressure, particularly in adult men, may be related to the effect of lead on calcium-mediated control of vascular smooth muscle contraction and on the renin-angiotensin system. Reproductive effects of lead have long been suspected, but low-level effects have not been well studied. Whether lead is a carcinogen or its association with renal adenocarcinoma is a consequence of cystic nephropathy is uncertain. Major risk factors for lead toxicity in children in the United States include nutrition, particularly deficiencies of essential metals, calcium, iron, and zinc, and housing and socioeconomic status. A goal for the year 2000 is to reduce prevalence of blood lead levels exceeding 15 micrograms/dL. 97 refs.

  14. P2-13: Location word Cues' Effect on Location Discrimination Task: Cross-Modal Study

    Directory of Open Access Journals (Sweden)

    Satoko Ohtsuka

    2012-10-01

    Full Text Available As is well known, participants are slower and make more errors in responding to the display color of an incongruent color word than a congruent one. This traditional stroop effect is often accounted for with relatively automatic and dominant word processing. Although the word dominance account has been widely supported, it is not clear in what extent of perceptual tasks it is valid. Here we aimed to examine whether the word dominance effect is observed in location stroop tasks and in audio-visual situations. The participants were required to press a key according to the location of visual (Experiment 1 and audio (Experiment 2 targets, left or right, as soon as possible. A cue of written (Experiments 1a and 2a or spoken (Experiments 1b and 2b location words, “left” or “right”, was presented on the left or right side of the fixation with cue lead times (CLT of 200 ms and 1200 ms. Reaction time from target presentation to key press was recorded as a dependent variable. The results were that the location validity effect was marked in within-modality but less so in cross-modality trials. The word validity effect was strong in within- but not in cross-modality trials. The CLT gave some effect of inhibition of return. So the word dominance could be less effective in location tasks and in cross-modal situations. The spatial correspondence seems to overcome the word effect.

  15. Potential Crash Location (PCL) Model

    Science.gov (United States)

    2014-02-05

    LCA ) model provides a method for calculating how large the actual lethal area at the site of impact would be. The LCA model is described in a...helicopter failures. The crash location calculations are just one portion of the TLS tool, the other portion is LCA . Although the LCA is not

  16. LOCATING LEAKS WITH ACOUSTIC TECHNOLOGY

    Science.gov (United States)

    Many water distribution systems in this country are almost 100 years old. About 26 percent of piping in these systems is made of unlined cast iron or steel and is in poor condition. Many methods that locate leaks in these pipes are time-consuming, costly, disruptive to operations...

  17. Competition in spatial location models

    NARCIS (Netherlands)

    Webers, H.M.

    1996-01-01

    Models of spatial competition are designed and analyzed to describe the fact that space, by its very nature, is a source of market power. This field of research, lying at the interface of game theory and economics, has attracted much interest because location problems are related to many aspects of

  18. Locating a buried earth penetrator

    Energy Technology Data Exchange (ETDEWEB)

    Caffey, T.W.H.

    1977-11-01

    The purpose of this work was to assist the recovery of a buried earth penetrator by locating the vertical projection of the penetator upon the surface within a horizontal radius error of one meter. The penetrator will carry a small coil which is driven by an alternating current to form a magnetic dipole. Five measurements of the magnetic field vector upon the surface of the earth are shown to be sufficient for determining not only the xyz-coordinates of the dipole, but also the orientation of the dipole axis. The theory, computation process, and field tests are comprehensively described. Results of 26 field tests with the dipole at 9 different combinations of location and orientation are given. Average radial and vertical location errors are 0.27 m and -0.05 m, respectively, while the mean errors in the tilt and orientation angles of the dipole axis are 3 degrees and 8 degrees, respectively. The results are applied to the design of a locating system for a Pershing II penetrator which contains a recessed, rear-mounted coil.

  19. Competition in spatial location models

    NARCIS (Netherlands)

    Webers, H.M.

    1996-01-01

    Models of spatial competition are designed and analyzed to describe the fact that space, by its very nature, is a source of market power. This field of research, lying at the interface of game theory and economics, has attracted much interest because location problems are related to many aspects of

  20. Lead Time Study,

    Science.gov (United States)

    1982-05-01

    AD-A128 318 LEAD TIME STUDY (U) ARMY ARMAMENT RESEARCH AND DEVELOPMENT CDMMAND DOVER NJ SYSTEMS ANALYSIS DIV dI-T~~ CHU MAY 82 ARRAA 82- 3/ /l N...EhhEEE--E 1111.0 U 1 - I 1120 1.25I1,,-. 11.6 MICROCOPY RESOLUTION TESI CHARI NATIONAL BUREAU 01 STANDARDt 19t,3 A co LEAD TIME STUDY c*A JULIE CHU MAY...188 D I.-f . . .... .. - r - .. " ’- -~ L - - _ _ __ ARRAA 82-3 LEAD TIME STUDY Prepared by:_ JL CHU Reviewed by:Li t’ ( LAWRENCE J. QWUNI Chief, Sys

  1. Lead effects on fungi

    Energy Technology Data Exchange (ETDEWEB)

    Gullino, M.L.; Fiussello, N.

    1976-01-01

    Addition of 0.01M lead nitrate to media caused complete inhibition of most of a group of 80 strains of fungi of several genera. Those which did grow at all had an extended lag period in comparison to controls. At 0.001M all the fungi grew, but had thinner-than-normal mycelia and delayed fruiting body formation. Fusarium species and members of Class Basidiomycetes were among the most sensitive, and Penicillium and Aspergillus species were the most tolerant. Lead uptake rates varied positively with lead nitrate concentration in the media. 9 references, 2 figures, 3 tables.

  2. LOCATION AND ECONOMIC GROWTH:CASE STUDY IN CHINA

    Institute of Scientific and Technical Information of China (English)

    ZHONG Chun-ping

    2004-01-01

    This paper explores how location could affect economic growth and it has always been omitted in economic analysis. Geographic factors can affect economic activities. Three mechanisms of location affecting economic growth have been studied: consumption, production and migration. The initial superior location will take such advantages as lower transport costs and lower price level, so it could have higher consumption utility, higher productivity, and attract more human capital, then lead higher growth. Those regions with the superior location will have higher utility due to more product varities and the comparative lower price, and higher wage due to the production technology, and it would attract more individuals with higher human capital to move to this location. It is a kind of agglomeration, meaning the superior location will hold more advantages and higher growth rate, otherwise those locations with poor geographic factor will be even worse. Based on Chinese provincial economic growth experiences of these years, this paper does some empirical analysis by regressing on some variables including the geographic ones. In this paper, the dummy variables and population density are used to measure the location factor. And we find evidences supporting the view that dominant locations such as coastal areas grow faster, on the contrary,middle and western provinces grow slower. Location does affect economic growth.

  3. Efecto de la aplicación de material calcáreo sobre la calidad de agua y producción en estanques salinos de l.v.

    OpenAIRE

    Sonnenholzner, Stanislaus

    2003-01-01

    Efecto de la aplicación de material calcáreo sobre la calidad de agua y producción en estanques salinos de L.V. Los estanques de aquacultura deben ser encalados para corregir problemas de alcalinidad, dureza o acidez del agua y suelo basicamente. Para acuacultura se recomienda alcalinidades totales superiores a 20 mg/L (como CaCO3) para reducir la amplitud de las fluctuaciones diurnas de pH en el estanque por cambios en la concentración de dióxido de carbono generados por la fotosíntesis y...

  4. A randomized phase III multicenter trial comparing irinotecan in combination with the Nordic bolus 5-FU and folinic acid schedule or the bolus/infused de Gramont schedule (Lv5FU2) in patients with metastatic colorectal cancer

    DEFF Research Database (Denmark)

    Glimelius, B; Sørbye, H; Balteskard, L

    2008-01-01

    not differ (4% versus 6%, P = 0.3). Grade 3/4 neutropenia (11% versus 5%, P = 0.01) and grade 2 alopecia (18% versus 9%, P = 0.002) were more common in the FLIRI group. The 60-day mortality was 2.4% versus 2.1%. CONCLUSIONS: Irinotecan with the bolus Nordic schedule (FLIRI) is a convenient treatment with PFS...... and OS comparable to irinotecan with the Lv5FU2 schedule. Neutropenia and alopecia are more prevalent, but both regimens are equally well tolerated....

  5. Diseño y aplicación de un Programa de Comunicación de Riesgos para la salud ambiental infantil en un sitio contaminado con plomo y arsénico Designing and application of a Risk Communication Program for children environmental health on a lead and arsenic contaminated location

    Directory of Open Access Journals (Sweden)

    Ana Cristina Cubillas-Tejeda

    2011-10-01

    Full Text Available Una industria metalúrgica en la ciudad de San Luis Potosí, México ha contaminado el sitio con plomo (Pb y arsénico (As principalmente. Desde 1989 se han reportado por nuestro grupo altas concentraciones de Pb en sangre (PbS y As en orina (AsO en los niños del lugar. En el presente estudio se generó un Programa de Comunicación Riesgos (PCR para informar a los niños sobre los riesgos ambientales del sitio donde viven y que cambiaran conductas para disminuir la exposición al Pb y al As. Se trabajó con 170 niños (5 a 7 años de la zona. Se aplicó el PCR y se realizó la evaluación mediante análisis de dibujos, cuestionarios y monitoreo biológico. En los dibujos de los niños se encontraron elementos tóxicos tales como el Pb, la tierra contaminada, entre otros. En los cuestionarios aplicados a los niños y a los padres de familia se pudo apreciar un cambio en los conocimientos y en algunas conductas respecto a los contaminantes, sus efectos y su exposición. No se encontró una disminución en los niveles de PbS ni de AsO. Esto quizás porque la principal ruta de exposición no es únicamente el suelo, como se había contemplado anteriormente.A metallurgical industry in San Luis Potosí city, México, has contaminated the zone by lead (Pb and arsenic (As. Since 1989 were reported by our group high concentrations of Pb in blood (PbB and As in urine (AsU in the local children. In present work, a Risk Communication Program (RCP was generated to inform the children about the environmental risks of the site where they live, and to change conducts to diminish the exposure to Pb and As. We worked with 170 children (5 to 7 years of the zone. The RCP was applied and the evaluation was realized by means of analysis of drawings, questionnaires and biological monitoring. In drawings of the children appeared toxic elements such as Pb, contaminated soil, cigarettes, among others. In the questionnaires applied to the children and family parents it

  6. Lead User Innovation

    DEFF Research Database (Denmark)

    Brem, Alexander; Larsen, Henry

    2015-01-01

    , deliver and capture the value of an innovatively new device together. From the perspective of the lead user, we show antecedents and effects of social interaction between organizational actors and the lead user on the development of social capital, especially trust and shared imagination. The second case......User innovation and especially the integration of lead users is a key topic in the innovation management literature of recent years. This paper contributes by providing a rare perspective into what easily could be seen as innovation failure, shown from two perspectives. We show how a lack of shared...... imagination hampers participation and kills innovation between interdependent stakeholders at the threshold between invention and innovation in practice. We present a first case in the fun-sport industry where an external lead user and diverse firm representatives in different functions fail to create...

  7. Lead-210 contamination

    Energy Technology Data Exchange (ETDEWEB)

    Gray, P. [Peter Gray and Associates, Tulsa, OK (United States)

    1997-12-31

    Nearly all scrap dealers, smelters and other recyclers routinely monitor for radioactivity in shipments entering their facility. These sensitive radiation gate monitors easily detect radium-226 and most other radioactive nuclides. However, the type of detector normally used, sodium iodide scintillation crystals, will not detect the low energy gamma radiation emitted by lead-210 and its progeny. Since lead-210 is a common radioactive contaminant in certain industries, contaminated scrap metal from these industries may avoid detection at the recycler. Lead-210 is a decay product of radon-222 which is produced in small concentrations with natural gas. As the natural gas liquids, particularly ethane and propane, are separated from the natural gas, the radon concentrates in the ethane/propane fraction. The natural gas industry, particularly gas processing facilities and industries using ethane and propane as feed stocks can be significantly contaminated with the radon decay products, especially lead-210, bismuth-210 and polonium-210. Unless the scrap metal is decontaminated before sending to the recycler, the lead-210 contaminated scrap may be processed, resulting in some degree of radioactive contamination of the recycling facilities. Methods of detecting the low energy gamma radiation associated with lead-210 include the pancake G-M detector and the thin crystal-thin window scintillation detector.

  8. Location, Location, Location: How Would a High-Performing Charter School Network Fare in Different States?

    Science.gov (United States)

    Lozier, Chris; Rotherham, Andrew J.

    2011-01-01

    In this paper the authors do not examine different operating strategies for charter schools or analyze the impact of their often educationally intensive models on finance. Instead, because public charter schools are funded predominantly by public dollars, they simply ask what impact location--and its associated variances in public funding and the…

  9. Location predicting methods for UAVs

    Science.gov (United States)

    Peng, Xiaodong; Zhang, Yu

    2017-08-01

    Location prediction of unmanned aerial vehicle (UAV) is important for fighting with its enemy and ensuring its normal operation. This paper presents the motion model of UAVs and reduces the state space into 7 dimensions. The Bayesian Network, Markov Chain, Curve Fitting and Neural Network are introduced for designing predicting methods. Then Curve Fitting Predicting method, Markov Chain Predicting method, Bayesian Network Predicting method and Neural Network Predicting method are designed for UAVs. The simulation result shows that 1) Neural Network Predicting method has highest predicting accuracy; 2) Markov Chain Predicting method and Bayesian Network Predicting method methods have similar performance and both are better than Bayesian Network Predicting method methods; 3) Neural Network Predicting method is the first choice when predicting the locations of UAVs.

  10. Location Privacy in RFID Applications

    Science.gov (United States)

    Sadeghi, Ahmad-Reza; Visconti, Ivan; Wachsmann, Christian

    RFID-enabled systems allow fully automatic wireless identification of objects and are rapidly becoming a pervasive technology with various applications. However, despite their benefits, RFID-based systems also pose challenging risks, in particular concerning user privacy. Indeed, improvident use of RFID can disclose sensitive information about users and their locations allowing detailed user profiles. Hence, it is crucial to identify and to enforce appropriate security and privacy requirements of RFID applications (that are also compliant to legislation). This chapter first discusses security and privacy requirements for RFID-enabled systems, focusing in particular on location privacy issues. Then it explores the advances in RFID applications, stressing the security and privacy shortcomings of existing proposals. Finally, it presents new promising directions for privacy-preserving RFID systems, where as a case study we focus electronic tickets (e-tickets) for public transportation.

  11. Orthogonal coding of object location.

    Science.gov (United States)

    Knutsen, Per Magne; Ahissar, Ehud

    2009-02-01

    It has been argued whether internal representations are encoded using a universal ('the neural code') or multiple codes. Here, we review a series of experiments that demonstrate that tactile encoding of object location via whisking employs an orthogonal, triple-code scheme. Rats, and other rodents, actively move the whiskers back and forth to localize and identify objects. Neural recordings from primary sensory afferents, along with behavioral observations, demonstrate that vertical coordinates of contacted objects are encoded by the identity of activated afferents, horizontal coordinates by the timing of activation and radial coordinates by the intensity of activation. Because these codes are mutually independent, the three-dimensional location of an object could, in principle, be encoded by individual afferents during single whisker-object contacts. One advantage of such a same-neuron-different-codes scheme over the traditionally assumed same-code-different-neurons scheme is a reduction of code ambiguity that, in turn, simplifies decoding circuits.

  12. Unexpected location of pilonidal sinuses.

    Science.gov (United States)

    Sion-Vardy, N; Osyntsov, L; Cagnano, E; Osyntsov, A; Vardy, D; Benharroch, D

    2009-12-01

    Pilonidal sinuses usually occur in the sacrococcygeal area in young men, and occasionally can be found in other ectopic sites. We present a retrospective case review on unusual locations of pilonidal sinuses in the past 4 years. The lesion sites were as follows: one on the penis, two on the scalp, two on the abdomen, one on the neck, two in the groin and two in the axilla. Abdominal and penile lesions are uncommon, but the other locations reported are unusually rare. To our knowledge, the groin has not been reported previously as a site of a pilonidal sinus, although the histological appearance of hidradenitis suppurativa may well resemble it. When trying to clarify the pathogenesis of these occurrences, we found that recurrent hair removal was a common characteristic of the patients we contacted, and this may have been the initiating trauma.

  13. Clowning, Location, and Mediterranean Drama

    OpenAIRE

    Publicover, Laurence

    2015-01-01

    This essay explores the ways in which early modern clowns disturb both spatial and generic decorum within early modern drama, and examines the ideological implications of these disturbances. With a particular focus on plays set in the Mediterranean, it demonstrates how clown-figures, through a variety of techniques, refocus attention on the performance space even at moments when plays seem most concerned with the real geographical locations they present. The essay ends by considering the impa...

  14. Computer Model Locates Environmental Hazards

    Science.gov (United States)

    2008-01-01

    Catherine Huybrechts Burton founded San Francisco-based Endpoint Environmental (2E) LLC in 2005 while she was a student intern and project manager at Ames Research Center with NASA's DEVELOP program. The 2E team created the Tire Identification from Reflectance model, which algorithmically processes satellite images using turnkey technology to retain only the darkest parts of an image. This model allows 2E to locate piles of rubber tires, which often are stockpiled illegally and cause hazardous environmental conditions and fires.

  15. Rare locations of calcifying tendinitis

    Energy Technology Data Exchange (ETDEWEB)

    Nidecker, A.; Hartweg, H.

    1983-12-01

    5 case-reports illustrate 2 rare locations of calcifying peritendinitis: The insertion of the deltoid tendon in the proximal humreus and the insertion of the gluteus maximus tendon in the femur. Knowledge of these insertion sites on one hand and the possibility of calcifying tendinitis at these sites on the other hand may allow proper diagnosis of certain shoulder- and hip joint pain syndromes and subsequent correct therapy.

  16. Underwater Acoustic Beacon Location System

    Science.gov (United States)

    2016-12-23

    transpose operator is a standard operator in linear or matrix algebra . The transpose operator converts the row vector   T aaaa z,y,x=P to a column...February 2017 The below identified patent application is available for licensing. Requests for information should be addressed to...300087 1 of 31 UNDERWATER ACOUSTIC BEACON LOCATION SYSTEM [0001] The present application claims the benefit of United States Provisional

  17. Uranium Critical Point Location Problem

    CERN Document Server

    Iosilevskiy, Igor

    2013-01-01

    Significant uncertainty of our present knowledge for uranium critical point parameters is under consideration. Present paper is devoted to comparative analysis of possible resolutions for the problem of uranium critical point location, as well as to discussion of plausible scheme of decisive experiment, which could resolve existing uncertainty. New calculations of gas-liquid coexistence in uranium by modern thermodynamic code are included in the analysis.

  18. Location Estimation using Delayed Measurements

    DEFF Research Database (Denmark)

    Bak, Martin; Larsen, Thomas Dall; Nørgård, Peter Magnus

    1998-01-01

    When combining data from various sensors it is vital to acknowledge possible measurement delays. Furthermore, the sensor fusion algorithm, often a Kalman filter, should be modified in order to handle the delay. The paper examines different possibilities for handling delays and applies a new techn...... technique to a sensor fusion system for estimating the location of an autonomous guided vehicle. The system fuses encoder and vision measurements in an extended Kalman filter. Results from experiments in a real environment are reported...

  19. Electronic warfare target location methods

    CERN Document Server

    Poisel, Richard

    2012-01-01

    Describing the mathematical development underlying current and classical methods of geolocating electronic systems that are emitting, this newly revised and greatly expanded edition of a classic Artech House book offers practical guidance in electronic warfare target location. The Second Edition features a wealth of additional material including new chapters on time delay estimation, direction finding techniques, and the MUSIC algorithm. This practical resource provides you with critical design information on geolocation algorithms, and establishes the fundamentals of existing algorithms as a

  20. Location, Location: Jurisdiction & Conflicts in Transborder Contract Litigation

    DEFF Research Database (Denmark)

    Lookofsky, Joseph

    In transborder contract litigation place-based factors are often decisive, both as regards jurisdiction to adjudicate as well as the rules which determine the applicable substantive law. Relevant locations include the place where the contract was made, where the parties reside, transact business...... or own property, the place of delivery, payment or other performance etc. Using concrete case-based examples, Professor Lookofsky explains how rules of jurisdiction and contract conflicts in Europe are tied to rigidly defined, single-place-based factors. In the United States, by contrast...

  1. Iepazīšanās virtuālā vidē: iepazīšanās portāla otrapuse.lv analīze

    OpenAIRE

    Brīnuma, Agnese

    2013-01-01

    Pētījums „Iepazīšanās virtuālā vidē: iepazīšanās portāla otrapuse.lv analīze” pēta virtuālās iepazīšanās kultūras specifiku. Iepazīšanās portālu iespējas ir plašas un ikvienam indivīdam paredzētas, tomēr paliek jautājums, vai tiešām to uzbūve veicina un sekmē solīto, kādi ir to ieguvumi un zaudējumi, drošības aspekti un publicējamo datu iespējas, turklāt kā indivīda identitātes atspoguļošana mainās atkarībā no mērķa. Pētījuma mērķis ir izpētīt portālu otrapuse.lv, izprast tā vidi, iepazīš...

  2. Leading healthcare in complexity.

    Science.gov (United States)

    Cohn, Jeffrey

    2014-12-01

    Healthcare institutions and providers are in complexity. Networks of interconnections from relationships and technology create conditions in which interdependencies and non-linear dynamics lead to surprising, unpredictable outcomes. Previous effective approaches to leadership, focusing on top-down bureaucratic methods, are no longer effective. Leading in complexity requires leaders to accept the complexity, create an adaptive space in which innovation and creativity can flourish and then integrate the successful practices that emerge into the formal organizational structure. Several methods for doing adaptive space work will be discussed. Readers will be able to contrast traditional leadership approaches with leading in complexity. They will learn new behaviours that are required of complexity leaders, along with challenges they will face, often from other leaders within the organization.

  3. Locating influential nodes in complex networks

    Science.gov (United States)

    Malliaros, Fragkiskos D.; Rossi, Maria-Evgenia G.; Vazirgiannis, Michalis

    2016-01-01

    Understanding and controlling spreading processes in networks is an important topic with many diverse applications, including information dissemination, disease propagation and viral marketing. It is of crucial importance to identify which entities act as influential spreaders that can propagate information to a large portion of the network, in order to ensure efficient information diffusion, optimize available resources or even control the spreading. In this work, we capitalize on the properties of the K-truss decomposition, a triangle-based extension of the core decomposition of graphs, to locate individual influential nodes. Our analysis on real networks indicates that the nodes belonging to the maximal K-truss subgraph show better spreading behavior compared to previously used importance criteria, including node degree and k-core index, leading to faster and wider epidemic spreading. We further show that nodes belonging to such dense subgraphs, dominate the small set of nodes that achieve the optimal spreading in the network.

  4. New Location Improves Efficiency | Poster

    Science.gov (United States)

    By Nancy Parrish, Staff Writer The physical proximity of the SAIC-Frederick Intellectual Property (IP) Office to the NCI Technology Transfer Center (NCI-TTC) is one of the many benefits of being at the Advanced Technology Research Facility (ATRF), according to Courtney Silverthorn, Ph.D. Being in one location “has increased the effectiveness of both informal communication and formal meetings. We have already brainstormed solutions for several issues in the hallway during an informal chat,” said Silverthorn, an SAIC-Frederick IP specialist.

  5. BIRTH LOCATIONS OF THE KEPLER CIRCUMBINARY PLANETS

    Energy Technology Data Exchange (ETDEWEB)

    Silsbee, Kedron; Rafikov, Roman R., E-mail: ksilsbee@astro.princeton.edu [Department of Astrophysical Sciences, Princeton University, Ivy Lane, Princeton, NJ 08540 (United States)

    2015-07-20

    The Kepler mission has discovered about a dozen circumbinary planetary systems, all containing planets on ∼1 AU orbits. We place bounds on the locations in the circumbinary protoplanetary disk, where these planets could have formed through collisional agglomeration starting from small (kilometer-sized or less) planetesimals. We first present a model of secular planetesimal dynamics that accounts for the (1) perturbation due to the eccentric precessing binary, as well as the (2) gravity and (3) gas drag from a precessing eccentric disk. Their simultaneous action leads to rich dynamics, with (multiple) secular resonances emerging in the disk. We derive analytic results for size-dependent planetesimal eccentricity and demonstrate the key role of the disk gravity for circumbinary dynamics. We then combine these results with a simple model for collisional outcomes and find that in systems like Kepler-16, planetesimal growth starting with 10–100 m planetesimals is possible outside a few AU. The exact location exterior to which this happens is sensitive to disk eccentricity, density, and precession rate, as well as to the size of the first generation of planetesimals. Strong perturbations from the binary in the inner part of the disk, combined with a secular resonance at a few AU, inhibit the growth of kilometer-sized planetesimals within 2–4 AU of the binary. In situ planetesimal growth in the Kepler circumbinary systems is possible only starting from large initial planetesimals (few-kilometer-sized even assuming favorable disk properties, i.e., low surface density)

  6. Locating Ectopic Foci on a Cylinder

    Science.gov (United States)

    Kuklik, Pawel; Zebrowski, Jan J.

    2003-07-01

    Arrhythmia is a condition in which an additional ectopic pacemaker is present in the tissue of the heart. Localization of ectopic foci is essential for successful radio-frequency ablation, an important surgical way of treating arrhythmia. In one of the possible mechanisms, arrhythmia induced by an ectopic foci located in one of the main blood vessels leading out or onto the heart. The therapeutic procedure in this case is usually ablation of the whole junction of the blood vessel with heart wall. In this way, whatever excitation occurs inside the vessel, it cannot penetrate the ventricles perturbing their contraction cycle. Such an ablation procedure is long and burdened with the risk of the perforation. A more safe method would involve the localization of the source of the excitation (i.e. the ectopic foci) and its ablation. The methods used in cardiology at present involve complicated localization systems and are time-consuming with the patient spending a long time on the operating table. Recently, Hall and Glass have developed numerical methods which allow to quickly to model the localization of the ectopic foci in a flat, square sample of an inhomogeneous medium. Here, we demonstrate an extension of this model for the case of a cylinder containing an ectopic foci, that can be a model of a blood vessel with the source of the ectopic beat inside it. Three methods of localization are implemented. Standard electrodes containing several active tips are used to stimulate the medium locally and locate the foci judging from the reaction of the system. The first one uses electrode activation times to compute the location of the ectopic site. The second one localizes it by measuring the resetting response of the foci, and the third one, uses wavefront curvature. Specifically for the cylindrical geometry of the blood vessel, we developed a localization procedure that allows to quickly localize the pacemaker.

  7. Relational Perspectives on Leading

    DEFF Research Database (Denmark)

    Larsen, Mette Vinther; Rasmussen, Jørgen Gulddahl

    2015-01-01

    Relational Perspectives on Leading discusses leadership from a relational and social constructionism perspective as practiced on an everyday basis between people. The book pursues a fast growing, practice-based approach - particularly within the Anglo-Saxon parts of the world - to organization...... studies and organizational phenomena....

  8. lead glass brick

    CERN Multimedia

    As well as accelerators to boost particles up to high energy, physicists need detectors to see what happens when those particles collide. This lead glass block is part of a CERN detector called OPAL. OPAL uses some 12 000 blocks of glass like this to measure particle energies.

  9. Girls Leading Outward

    Science.gov (United States)

    Hamed, Heather; Reyes, Jazmin; Moceri, Dominic C.; Morana, Laura; Elias, Maurice J.

    2011-01-01

    The authors describe a program implemented in Red Bank Middle School in New Jersey to help at-risk, minority middle school girls realize their leadership potential. The GLO (Girls Leading Outward) program was developed by the Developing Safe and Civil Schools Project at Rutgers University and is facilitated by university students. Selected middle…

  10. Leading by Learning

    Science.gov (United States)

    Brookhart, Susan M.; Moss, Connie M.

    2013-01-01

    A lot has changed in the principalship since the principal was the head teacher in a school. Current principals are building administrators and that is likely to continue, the authors posit. Nonetheless, they report their study focusing on leadership's role in formative assessment concluded that in order to lead learning the principal must become…

  11. Change, Lead, Succeed

    Science.gov (United States)

    Munger, Linda; von Frank, Valerie

    2010-01-01

    Redefine leadership in your school, and create capacity through school leadership teams that successfully coordinate professional learning. "Change, Lead, Succeed" shows school leaders and teachers in leadership roles what they need to know to effectively create a culture for change. Find out what distinguishes a school leadership team from other…

  12. An evaluation of location management procedures

    NARCIS (Netherlands)

    Baumann, Frank V.; Niemegeers, Ignas G.

    1994-01-01

    This paper gives a comparative description of two scenarios for location management in a mobile telecommunications system. The first scenario uses fixed location and paging areas. Mobiles perform a location update as they enter a new location area. The second scenario uses a time-out based location

  13. Global mapping of transposon location.

    Directory of Open Access Journals (Sweden)

    Abram Gabriel

    2006-12-01

    Full Text Available Transposable genetic elements are ubiquitous, yet their presence or absence at any given position within a genome can vary between individual cells, tissues, or strains. Transposable elements have profound impacts on host genomes by altering gene expression, assisting in genomic rearrangements, causing insertional mutations, and serving as sources of phenotypic variation. Characterizing a genome's full complement of transposons requires whole genome sequencing, precluding simple studies of the impact of transposition on interindividual variation. Here, we describe a global mapping approach for identifying transposon locations in any genome, using a combination of transposon-specific DNA extraction and microarray-based comparative hybridization analysis. We use this approach to map the repertoire of endogenous transposons in different laboratory strains of Saccharomyces cerevisiae and demonstrate that transposons are a source of extensive genomic variation. We also apply this method to mapping bacterial transposon insertion sites in a yeast genomic library. This unique whole genome view of transposon location will facilitate our exploration of transposon dynamics, as well as defining bases for individual differences and adaptive potential.

  14. ATM protein is located on presynaptic vesicles and its deficit leads to failures in synaptic plasticity.

    Science.gov (United States)

    Vail, Graham; Cheng, Aifang; Han, Yu Ray; Zhao, Teng; Du, Shengwang; Loy, Michael M T; Herrup, Karl; Plummer, Mark R

    2016-07-01

    Ataxia telangiectasia is a multisystemic disorder that includes a devastating neurodegeneration phenotype. The ATM (ataxia-telangiectasia mutated) protein is well-known for its role in the DNA damage response, yet ATM is also found in association with cytoplasmic vesicular structures: endosomes and lysosomes, as well as neuronal synaptic vesicles. In keeping with this latter association, electrical stimulation of the Schaffer collateral pathway in hippocampal slices from ATM-deficient mice does not elicit normal long-term potentiation (LTP). The current study was undertaken to assess the nature of this deficit. Theta burst-induced LTP was reduced in Atm(-/-) animals, with the reduction most pronounced at burst stimuli that included 6 or greater trains. To assess whether the deficit was associated with a pre- or postsynaptic failure, we analyzed paired-pulse facilitation and found that it too was significantly reduced in Atm(-/-) mice. This indicates a deficit in presynaptic function. As further evidence that these synaptic effects of ATM deficiency were presynaptic, we used stochastic optical reconstruction microscopy. Three-dimensional reconstruction revealed that ATM is significantly more closely associated with Piccolo (a presynaptic marker) than with Homer1 (a postsynaptic marker). These results underline how, in addition to its nuclear functions, ATM plays an important functional role in the neuronal synapse where it participates in the regulation of presynaptic vesicle physiology.

  15. Acquisition of Locative Meanings: "Behind" and "In Front Of."

    Science.gov (United States)

    Johnston, Judith R.

    1984-01-01

    Explores the early use of "behind" and "in front of" with large reference objects among 33 children. The patterns for the use of these locatives suggest an acquisition process in which new conceptual resources lead to the re-analysis of object configurations and thus to new aspects of meaning. (SED)

  16. Drinking water assessment of 4 locations from Ghaziabad, Uttar Pradesh

    Directory of Open Access Journals (Sweden)

    Shikha Bisht

    2013-04-01

    Full Text Available In this study drinking water samples from 4 different locations in Ghaziabad were collected by random grab sampling. These were analyzed for physiochemical and elemental parameters. The parameters tested were pH, Nitrate, Fluoride, Chloride, Sulphate, Total Dissolved solids, Hardness, Alkalinity, Calcium, Magnesium, Aluminium, Boron, Zinc, Selenium, Manganese, Iron, Chromium, Copper, Lead, Cadmium, Arsenic and Mercury.

  17. Amyotrophic lateral sclerosis as a spatiotemporal mislocalization disease: location, location, location.

    Science.gov (United States)

    Gershoni-Emek, Noga; Chein, Michael; Gluska, Shani; Perlson, Eran

    2015-01-01

    Spatiotemporal localization of signals is a fundamental feature impacting cell survival and proper function. The cell needs to respond in an accurate manner in both space and time to both intra- and intercellular environment cues. The regulation of this comprehensive process involves the cytoskeleton and the trafficking machinery, as well as local protein synthesis and ligand-receptor mechanisms. Alterations in such mechanisms can lead to cell dysfunction and disease. Motor neurons that can extend over tens of centimeters are a classic example for the importance of such events. Changes in spatiotemporal localization mechanisms are thought to play a role in motor neuron degeneration that occurs in amyotrophic lateral sclerosis (ALS). In this review we will discuss these mechanisms and argue that possible misregulated factors can lead to motor neuron degeneration in ALS.

  18. Influence of Slippery Pacemaker Leads on Lead-Induced Venous Occlusion

    Science.gov (United States)

    Yang, Weiguang; Bhatia, Sagar; Obenauf, Dayna; Resse, Max; Esmaily-Moghadam, Mahdi; Feinstein, Jeffrey; Pak, On Shun

    2016-11-01

    The use of medical devices such as pacemakers and implantable cardiac defibrillators have become commonplace to treat arrhythmias. Pacing leads with electrodes are used to send electrical pulses to the heart to treat either abnormally slow heart rates, or abnormal rhythms. Lead induced vessel occlusion, which is commonly seen after placement of pacemaker or ICD leads, may result in lead malfunction and/or SVC syndrome, and makes lead extraction difficult. The association between the anatomic locations at risk for thrombosis and regions of venous stasis have been reported previously. The computational studies reveal obvious flow stasis in the proximity of the leads, due to the no-slip boundary condition imposed on the lead surface. With the advent of recent technologies capable of creating slippery surfaces that can repel complex fluids including blood, we explore computationally how local flow structures may be altered in the regions around the leads when the no-slip boundary condition on the lead surface is relaxed using various slip lengths. The findings evaluate the possibility of mitigating risks of lead-induced thrombosis and occlusion by implementing novel surface conditions (i.e. theoretical coatings) on the leads.

  19. CMS lead tungstate crystals

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    These crystals are made from lead tungstate, a crystal that is as clear as glass yet with nearly four times the density. They have been produced in Russia to be used as scintillators in the electromagnetic calorimeter on the CMS experiment, part of the LHC project at CERN. When an electron, positron or photon passes through the calorimeter it will cause a cascade of particles that will then be absorbed by these scintillating crystals, allowing the particle's energy to be measured.

  20. Leading Generation Y

    Science.gov (United States)

    2008-04-01

    ensure the success of their child, failure is not often experienced. These successes and the ease of childhood lead to not only confidence but an...Messaging, chatting on the cell phone and working on homework is a common place scene for teens and college students. “The level of multiprocessing...to Gen Yers entering the workforce with unrealistic expectations and a sense of entitlement. Barbara Dwyer, CEO of the Job Journey, states that

  1. Locating Cosmopolitanism Within Academic Mobility

    Directory of Open Access Journals (Sweden)

    Liudmila Kirpitchenko

    2014-02-01

    Full Text Available Intensified academic mobility is an enticing platform for examining the emerging manifestations of cosmopolitanism in expanding intercultural encounters. Cosmopolitanism calls for a dialogue between cultures and for reciprocal appropriation and internalization of cultures within one’s own culture. This paper endeavors to locate empirical evidence on evolving cosmopolitanism in everyday intercultural interactions and academic experiences. It is guided by the methodological applications of cosmopolitanism and the way cosmopolitanism is redefining the sociological frame of reference. This paper presents discussion and empirical testing of three defining features of cosmopolitanism according to Beck (2002: globality, plurality and civility. Mirroring these guiding principles, this research attempted to identify and analyze cosmopolitan values and dispositions in everyday intercultural encounters, discourses, situations and experiences. This paper presented an argument that cosmopolitan values and dispositions tend to create mutually beneficial conditions for intercultural inclusion and academic mobility provides a fertile ground for their current and future exploration.

  2. Heat exchanger leakage problem location

    Directory of Open Access Journals (Sweden)

    Jícha Miroslav

    2012-04-01

    Full Text Available Recent compact heat exchangers are very often assembled from numerous parts joined together to separate heat transfer fluids and to form the required heat exchanger arrangement. Therefore, the leak tightness is very important property of the compact heat exchangers. Although, the compact heat exchangers have been produced for many years, there are still technological problems associated with manufacturing of the ideal connection between the individual parts, mainly encountered with special purpose heat exchangers, e.g. gas turbine recuperators. This paper describes a procedure used to identify the leakage location inside the prime surface gas turbine recuperator. For this purpose, an analytical model of the leaky gas turbine recuperator was created to assess its performance. The results obtained are compared with the experimental data which were acquired during the recuperator thermal performance analysis. The differences between these two data sets are used to indicate possible leakage areas.

  3. Heat exchanger leakage problem location

    Science.gov (United States)

    Hejčík, Jiří; Jícha, Miroslav

    2012-04-01

    Recent compact heat exchangers are very often assembled from numerous parts joined together to separate heat transfer fluids and to form the required heat exchanger arrangement. Therefore, the leak tightness is very important property of the compact heat exchangers. Although, the compact heat exchangers have been produced for many years, there are still technological problems associated with manufacturing of the ideal connection between the individual parts, mainly encountered with special purpose heat exchangers, e.g. gas turbine recuperators. This paper describes a procedure used to identify the leakage location inside the prime surface gas turbine recuperator. For this purpose, an analytical model of the leaky gas turbine recuperator was created to assess its performance. The results obtained are compared with the experimental data which were acquired during the recuperator thermal performance analysis. The differences between these two data sets are used to indicate possible leakage areas.

  4. Superconductivity of lead

    Energy Technology Data Exchange (ETDEWEB)

    Boorse, H.A.; Cook, D.B.; Zemansky, W.M.

    1950-06-01

    Numerous determinations of the zero-field transition temperature of lead have been made. All of these observations except that of Daunt were made by the direct measurement of electrical resistance. Daunt`s method involved the shielding effect of persistent currents in a hollow cylinder. In the authors work on columbium to be described in a forthcoming paper an a.c. induction method was used for the measurement of superconducting transitions. The superconductor was mounted as a cylindrical core of a coil which functioned as the secondary of a mutual inductance. The primary coil was actuated by an oscillator which provided a maximum a.c. field within the secondary of 1.5 oersteds at a frequency of 1000 cycles per second. The secondary e.m.f. which was dependent for its magnitude on the permeability of the core was amplified, rectifie, and observed on a recording potentiometer. During the application of this method to the study of columbium it appeared that a further check on the zero-field transition temperature of lead would be worth while especially if agreement between results for very pure samples could be obtained using this method. Such result would help in establishing the lead transition temperature as a reasonably reproducible reference point in the region between 4 deg and 10 deg K.

  5. The LHCb Vertex Locator performance and Vertex Locator upgrade

    CERN Document Server

    INSPIRE-00259789

    2012-01-01

    LHCb is an experiment dedicated to the study of new physics in the decays of beauty and charm hadrons at the Large Hadron Collider (LHC) at CERN. The Vertex Locator (VELO) is the silicon detector surrounding the LHCb interaction point. The detector operates in a severe and highly non-uniform radiation environment. The small pitch and analogue readout result in a best single hit precision of 4 $\\rm \\mu$m. The upgrade of the LHCb experiment, planned for 2018, will transform the entire readout to a trigger-less system operating at 40 MHz event rate. The vertex detector will have to cope with radiation levels up to 10$^{16}$ 1 MeV$\\rm n_{eq}/cm^2$, more than an order of magnitude higher than those expected at the current experiment. A solution is under development with a pixel detector, based on the Timepix/Medipix family of chips with 55 x 55 $\\rm \\mu m$ pixels. In addition a micro-strip solution is also under development, with finer pitch, higher granularity and lower mass than the current detector. The current...

  6. Site-specific lead exposure from lead pellet ingestion in sentinel mallards

    Science.gov (United States)

    Rocke, T.E.; Brand, C.J.; Mensik, John G.

    1997-01-01

    We monitored lead poisoning from the ingestion of spent lead pellets in sentinel mallards (Anas platyhrynchos) at the Sacramento National Wildlife Refuge (SNWR), Willows, California for 4 years (1986-89) after the conversion to steel shot for waterfowl hunting on refuges in 1986. Sentinel mallards were held in 1.6-ha enclosures in 1 hunted (P8) and 2 non-hunted (T19 and TF) wetlands. We compared site-specific rates of lead exposure, as determined by periodic measurement of blood lead concentrations, and lead poisoning mortality between wetlands with different lead pellet densities, between seasons, and between male and female sentinels. In 1986, the estimated 2-week rate of lead exposure was significantly higher (P 2,000,000 pellets/ha), than in those with lower densities of lead pellets, T19 (18.1%; 173,200 pellets/ha) and TF (0.9%; 15,750 pellets/ha). The probability of mortality from lead poisoning was also significantly higher (P < 0.01) in sentinel mallards enclosed in P8 (0.25) than T19 (0) and TF (0) in 1986 and remained significantly higher (P < 0.001) during the 4-year study. Both lead exposure and the probability of lead poisoning mortality in P8 were significantly higher (P < 0.001) in the fall of 1986 (43.8%; 0.25), before hunting season, than in the spring of 1987 (21.6%; 0.04), after hunting season. We found no significant differences in the rates of lead exposure or lead poisoning mortality between male and female sentinel mallards. The results of this study demonstrate that in some locations, lead exposure and lead poisoning in waterfowl will continue to occur despite the conversion to steel shot for waterfowl hunting.

  7. Optimization leads to symmetry

    Institute of Scientific and Technical Information of China (English)

    Chenghong WANG; Yuqian GUO; Daizhan CHENG

    2004-01-01

    The science of complexity studies the behavior and properties of complex systems in nature and human society.Particular interest has been put on their certain simple common properties.Symmetry is one of such properties.Symmetric phenomena can be found in many complex systems.The purpose of this paper is to reveal the internal reason of the symmetry.Using some physical systems and geometric objects,the paper shows that many symmetries are caused by optimization under certain criteria.It has also been revealed that an evolutional process may lead to symmetry.

  8. Leading change: 2--planning.

    Science.gov (United States)

    Kerridge, Joanna

    National initiatives have outlined the importance of involving frontline staff in service improvement, and the ability to influence and manage change has been identified as an essential skill for delivering new models of care. Nurses often have to take the lead in managing change in clinical practice. The second in a three-part series is designed to help nurses at all levels develop the knowledge and skills to function as change agents within their organisations. This article focuses on planning the change and dealing with resistance.

  9. lead glass brick

    CERN Multimedia

    When you look through the glass at a picture behind, the picture appears raised up because light is slowed down in the dense glass. It is this density (4.06 gcm-3) that makes lead glass attractive to physicists. The refractive index of the glass is 1.708 at 400nm (violet light), meaning that light travels in the glass at about 58% its normal speed. At CERN, the OPAL detector uses some 12000 blocks of glass like this to measure particle energies.

  10. Turning lead into gold

    DEFF Research Database (Denmark)

    Jensen, Steffen Moltrup Ernø

    For years the field of entrepreneurship has been blinded by the alchemical promise of turning lead into gold, of finding the ones most likely to become the next Branson, Zuckerberg or Gates. The promise has been created in the midst of political and scientific agendas where certain individuals...... is not to accumulate state or market wealth, but for entrepreneurial skills to become tools towards the liberation of the individual from oppressive systems of control – essentially to add public value rather than economic value. In this presentation I will sketch an anarchist perspective on entrepreneurship, looking...

  11. PSYCHOMETRIC ANALYSIS OF TWO ANALOGOUS VALUE ASSESSMENT TOOLS: «TERMINAL VALUES QUESTIONNAIRE» BY I.G. SENIN AND «AXIOLOGICAL ORIENTATION OF THE PERSONALITY» QUESTIONNAIRE BY A.V. KAPTSOV & L.V. KARPUSHINA

    Directory of Open Access Journals (Sweden)

    Aleksey Yur’evich Kalugin

    2015-03-01

    Full Text Available The increase in the number of psychodiagnostic methods, aimed at the study of the value-semantic sphere confronts researchers with the task of selecting the most reliable and valid instruments. We set the task to conduct psychometric studies of two analogous tools that measure axiological sphere of personality: «Terminal values questionnaire» by I.G. Senin, «Axiological orientation of the personality» test by A.V. Kaptsov & L.V. Karpushina. Scales were checked for internal consistency, and construct validity of questionnaires was studied in greater detail. We offer an approach to the study of construct validity through comparing empirically obtained constructs with theoretical constructs on the basis of objective indicators of interrelations between them.

  12. Church splits in the Don region in 1920-1930s. Collection of documents and materials / L.V. Tabunshchikovа, A.V. Shadrinа. Rostov-on-Don: Antaeus, 2015. 640 p.

    Directory of Open Access Journals (Sweden)

    Andrey A. Kostryukov

    2016-06-01

    Full Text Available The review is devoted to the collection of documents and materials “Church Split in the Don region in 1920–1930”, published in 2015. The Compilers, L.V. Tabunshchikovа and A.V. Shadrina, identified and prepared for publication 260 documents, covering the period from the beginning of Renovationist (1922 and Gregorian (1925 splits up to their elimination in the Rostov region in the mid-1940s. The vast majority of documents have been published for the first time. They show that the GPU initiated Renovationist and Gregorian schisms in the Don. The compilers identified four diocesan Renovationist centers, the names of not only Renovationist and Gregorian, but also anti-Renovationist Don bishops.

  13. Retraction: 'rhBNP therapy can improve clinical outcomes and reduce in-hospital mortality compared with dobutamine in heart failure patients: a meta-analysis' by Ming-Yi Lv, Shu-Ling Deng and Xiao-Feng Long.

    Science.gov (United States)

    2016-05-01

    The above article, published online on 28(th) November 2015 in Wiley Online Library (http://onlinelibrary.wiley.com/doi/10.1111/bcp.12788/full), and in volume 81, pp. 174-185, has been retracted by agreement between the authors, the journal Editor in Chief, Professor A Cohen, and John Wiley & Sons Limited. The retraction has been agreed owing to evidence indicating that the peer review of this paper was compromised. The authors were unaware of the actions of the third party responsible for compromising the peer review. Reference Lv M-Y, Deng S-L, Long X-F. rhBNP therapy can improve clinical outcomes and reduce in-hospital mortality compared with dobutamine in heart failure patients: a meta-analysis. Br J Clin Pharmacol 2016; 81: 174-85. doi:10.1111/bcp.12788.

  14. The nationalism in the teaching application of Zheng Lv-cheng's music creation%浅谈郑律成音乐创作中的民族性在教学中应用

    Institute of Scientific and Technical Information of China (English)

    钱岩; 张德俊

    2015-01-01

    Zheng Lv-cheng is the famous Korean music artists in our country, its creation involves all kinds of music genre, this paper advanced world view and aesthetic view, deep thoughts and persistence study spirit, emotion and independent personality three aspects to talk about the nationality of the music works.%郑律成是我国著名的朝鲜族音乐艺术家,其创作涉及各种音乐体裁,本文从先进的世界观与审美观、深邃的思想与锲而不舍的求学精神、丰富的情感与独立的人格三个方面来谈其音乐作品的民族性.

  15. Location, Location, Location: Eye-Tracking Evidence that Consumers Preferentially View Prominently Positioned Nutrition Information

    Science.gov (United States)

    Graham, Dan J.; Jeffery, Robert W.

    2012-01-01

    Background Nutrition Facts labels can keep consumers better informed about their diets' nutritional composition, however, consumers currently do not understand these labels well or use them often. Thus, modifying existing labels may benefit public health. Objective The present study tracked the visual attention of individuals making simulated food-purchasing decisions to assess Nutrition Facts label viewing. Primary research questions were how self-reported viewing of Nutrition Facts labels and their components relates to measured viewing and whether locations of labels and specific label components relate to viewing. Design The study involved a simulated grocery shopping exercise conducted on a computer equipped with an eye-tracking camera. A post-task survey assessed self-reported nutrition information viewing, health behaviors, and demographics. Subjects/setting Individuals 18 years old and older and capable of reading English words on a computer (n=203) completed the 1-hour protocol at the University of Minnesota during Spring 2010. Statistical analyses Primary analyses included χ2, analysis of variance, and t tests comparing self-reported and measured viewing of label components in different presentation configurations. Results Self-reported viewing of Nutrition Facts label components was higher than objectively measured viewing. Label components at the top of the label were viewed more than those at the bottom, and labels positioned in the center of the screen were viewed more than those located on the sides. Conclusions Nutrition Facts label position within a viewing area and position of specific components on a label relate to viewing. Eye tracking is a valuable technology for evaluating consumers' attention to nutrition information, informing nutrition labeling policy (eg, front-of-pack labels), and designing labels that best support healthy dietary decisions. PMID:22027053

  16. Blood Lead Levels and Health Problems of Lead Acid Battery Workers in Bangladesh

    Directory of Open Access Journals (Sweden)

    Sk. Akhtar Ahmad

    2014-01-01

    Full Text Available Introduction. Use of lead acid battery (LAB in Bangladesh has risen with sharp rise of motor vehicles. As result, manufacture of LAB is increasing. Most of the lead used by these industries comes from recycling of LAB. Workers in LAB industry are at risk of exposure lead and thus development of lead toxicity. Objective. The objective of this study was to measure the blood lead concentration and to assess the magnitude of health problems attributable to lead toxicity among the LAB manufacturing workers. Methods. A cross-sectional study was conducted among the workers of LAB manufacturing industries located in Dhaka city. Result. Mean blood lead level (BLL among the workers was found to be high. They were found to be suffering from a number of illnesses attributable to lead toxicity. The common illnesses were frequent headache, numbness of the limbs, colic pain, nausea, tremor, and lead line on the gum. High BLL was also found to be related to hypertension and anemia of the workers. Conclusion. High BLL and illnesses attributable to lead toxicity were prevalent amongst workers of the LAB manufacturing industries, and this requires attention especially in terms of occupational hygiene and safety.

  17. Quasiconvex optimization and location theory

    CERN Document Server

    Santos Gromicho, Jaoquim António

    1998-01-01

    grams of which the objective is given by the ratio of a convex by a positive (over a convex domain) concave function. As observed by Sniedovich (Ref. [102, 103]) most of the properties of fractional pro­ grams could be found in other programs, given that the objective function could be written as a particular composition of functions. He called this new field C­ programming, standing for composite concave programming. In his seminal book on dynamic programming (Ref. [104]), Sniedovich shows how the study of such com­ positions can help tackling non-separable dynamic programs that otherwise would defeat solution. Barros and Frenk (Ref. [9]) developed a cutting plane algorithm capable of optimizing C-programs. More recently, this algorithm has been used by Carrizosa and Plastria to solve a global optimization problem in facility location (Ref. [16]). The distinction between global optimization problems (Ref. [54]) and generalized convex problems can sometimes be hard to establish. That is exactly the reason ...

  18. Renal denervation in heart failure with normal left ventricular ejection fraction. Rationale and design of the DIASTOLE (DenervatIon of the renAl Sympathetic nerves in hearT failure with nOrmal Lv Ejection fraction) trial.

    Science.gov (United States)

    Verloop, Willemien L; Beeftink, Martine M A; Nap, Alex; Bots, Michiel L; Velthuis, Birgitta K; Appelman, Yolande E; Cramer, Maarten-Jan; Agema, Willem R P; Scholtens, Asbjorn M; Doevendans, Pieter A; Allaart, Cor P; Voskuil, Michiel

    2013-12-01

    Aim Increasing evidence suggests an important role for hyperactivation of the sympathetic nervous system (SNS) in the clinical phenomena of heart failure with normal LVEF (HFNEF) and hypertension. Moreover, the level of renal sympathetic activation is directly related to the severity of heart failure. Since percutaneous renal denervation (pRDN) has been shown to be effective in modulating elevated SNS activity in patients with hypertension, it can be hypothesized that pRDN has a positive effect on HFNEF. The DIASTOLE trial will investigate whether renal sympathetic denervation influences parameters of HFNEF. Methods DIASTOLE is a multicentre, randomized controlled trial. Sixty patients, diagnosed with HFNEF and treated for hypertension, will be randomly allocated in a 1:1 ratio to undergo renal denervation on top of medical treatment (n = 30) or to maintain medical treatment alone (n = 30). The primary objective is to investigate the efficacy of pRDN by means of pulsed wave Doppler echocardiographic parameters. Secondary objectives include safety of pRDN and a comparison of changes in the following parameters after pRDN: LV mass, LV volume, LVEF, and left atrial volume as determined by magnetic resonance imaging. Also, MIBG (metaiodobenzylguanidine) uptake and washout, BNP levels, blood pressure, heart rate variability, exercise capacity, and quality of life will be assessed. Perspective DIASTOLE is a randomized controlled trial evaluating renal denervation as a treatment option for HFNEF. The results of the current trial will provide important information regarding the treatment of HFNEF, and therefore may have major impact on future therapeutic strategies. Trail registration NCT01583881.

  19. Intra-myocardial injection of both growth factors and heart derived Sca-1+/CD31- cells attenuates post-MI LV remodeling more than does cell transplantation alone: neither intervention enhances functionally significant cardiomyocyte regeneration.

    Directory of Open Access Journals (Sweden)

    Xiaohong Wang

    Full Text Available Insulin-like growth factor 1 (IGF-1 and hepatocyte growth factor (HGF are two potent cell survival and regenerative factors in response to myocardial injury (MI. We hypothesized that simultaneous delivery of IGF+HGF combined with Sca-1+/CD31- cells would improve the outcome of transplantation therapy in response to the altered hostile microenvironment post MI. One million adenovirus nuclear LacZ-labeled Sca-1+/CD31- cells were injected into the peri-infarction area after left anterior descending coronary artery (LAD ligation in mice. Recombinant mouse IGF-1+HGF was added to the cell suspension prior to the injection. The left ventricular (LV function was assessed by echocardiography 4 weeks after the transplantation. The cell engraftment, differentiation and cardiomyocyte regeneration were evaluated by histological analysis. Sca-1+/CD31- cells formed viable grafts and improved LV ejection fraction (EF (Control, 54.5+/-2.4; MI, 17.6+/-3.1; Cell, 28.2+/-4.2, n = 9, P<0.01. IGF+HGF significantly enhanced the benefits of cell transplantation as evidenced by increased EF (38.8+/-2.2; n = 9, P<0.01 and attenuated adverse structural remodeling. Furthermore, IGF+HGF supplementation increased the cell engraftment rate, promoted the transplanted cell survival, enhanced angiogenesis, and minimally stimulated endogenous cardiomyocyte regeneration in vivo. The in vitro experiments showed that IGF+HGF treatment stimulated Sca-1+/CD31- cell proliferation and inhibited serum free medium induced apoptosis. Supperarray profiling of Sca-1+/CD31- cells revealed that Sca-1+/CD31- cells highly expressed various trophic factor mRNAs and IGF+HGF treatment altered the mRNAs expression patterns of these cells. These data indicate that IGF-1+HGF could serve as an adjuvant to cell transplantation for myocardial repair by stimulating donor cell and endogenous cardiac stem cell survival, regeneration and promoting angiogenesis.

  20. Privacy-Preserving Location-Based Services

    Science.gov (United States)

    Chow, Chi Yin

    2010-01-01

    Location-based services (LBS for short) providers require users' current locations to answer their location-based queries, e.g., range and nearest-neighbor queries. Revealing personal location information to potentially untrusted service providers could create privacy risks for users. To this end, our objective is to design a privacy-preserving…

  1. Privacy-Preserving Location-Based Services

    Science.gov (United States)

    Chow, Chi Yin

    2010-01-01

    Location-based services (LBS for short) providers require users' current locations to answer their location-based queries, e.g., range and nearest-neighbor queries. Revealing personal location information to potentially untrusted service providers could create privacy risks for users. To this end, our objective is to design a privacy-preserving…

  2. Privacy for location-based services

    CERN Document Server

    Ghinita, Gabriel

    2013-01-01

    Sharing of location data enables numerous exciting applications, such as location-based queries, location-based social recommendations, monitoring of traffic and air pollution levels, etc. Disclosing exact user locations raises serious privacy concerns, as locations may give away sensitive information about individuals' health status, alternative lifestyles, political and religious affiliations, etc. Preserving location privacy is an essential requirement towards the successful deployment of location-based applications. These lecture notes provide an overview of the state-of-the-art in locatio

  3. Privacy Preserving Location Proof Updating System

    Directory of Open Access Journals (Sweden)

    Dhinesh Kumar S.

    2015-11-01

    Full Text Available Location-sensitive service broadcasting on user’s mobile devices to discover the current location. A privacy preserving Location proof updating system(APPLAUS,which does not rely on the wide deployement of network infrastructure or the expensive trusted computing module.In APPLAUS, Bluetooth enabled mobile devices in range mutually generate location proofs,which are uploaded to a untrusted location proof. An authorized verifier can query and retrieve location proofs from the server.Moreover,our location proof system guarantees user location privacy from every party.Bluetooth enabled mobile devices in range mutually generate location proofs.CA used to be the bridges between the verifier and the location proof server.

  4. Privacy Preserving Location Proof Updating System

    Directory of Open Access Journals (Sweden)

    Dhinesh Kumar S.

    2014-03-01

    Full Text Available Location-sensitive service broadcasting on user’s mobile devices to discover the current location. A privacy preserving Location proof updating system(APPLAUS,which does not rely on the wide deployement of network infrastructure or the expensive trusted computing module.In APPLAUS, Bluetooth enabled mobile devices in range mutually generate location proofs,which are uploaded to a untrusted location proof. An authorized verifier can query and retrieve location proofs from the server.Moreover,our location proof system guarantees user location privacy from every party.Bluetooth enabled mobile devices in range mutually generate location proofs.CA used to be the bridges between the verifier and the location proof server..

  5. PAINT SUPPLIES AND LOCATION: EXAMINING ICI

    Directory of Open Access Journals (Sweden)

    M. Herron

    2016-01-01

    Full Text Available How important is location to an international retailer? Not just any retailer but the second largest paint retailer in the world. Imperial Chemical Industries (ICI was a British chemical company and was at one stage the largest manufacturer in Britain. Formed from the merger of several leading British chemical companies in 1926, ICI makes paints and speciality products, including food ingredients, speciality polymers, electronic materials, fragrances and flavourings. ICI paints purchased the Cleveland Ohiobased Glidden Coatings & Resins (Glidden Paint Company in 1986 for USD$580 million. The addition of Glidden to ICI's North American operations more than doubled that subsidiary's annual sales to $3 billion and increased ICI's corporate presence in the United States dramatically. A decline in paint and solvent consumption during the 2000 decade slowed the average growth of the paint industry to about 2% annually. Rauch Associates, the leading US paint analyst firm, predicted near-term growth to slow even further to 1.2% per annum. Through the 1990’s and early 2000’s Glidden paint was sold only through Glidden-badged paint stores and smaller retailers under licence, developing a strong identifiable brand and reputation. How were potential Glidden retail paint store locations chosen across America to enable and support this market growth? This paper investigates the real process that was developed and applied to construct a national network of retail outlets across the United States. It also highlights the change in direction that occurred at ICI paints culminating in its eventual acquisition by AkzoNobel in 2008 who immediately sold parts of ICI to Henkel, and integrated ICI's remaining operations within its existing organisation. This sale and the associated corporate restructure caused considerable change in marketing directions allowing for the first time the selling of Glidden paint products to mass market centres

  6. Impacts of converting from leaded to unleaded gasoline on ambient lead concentrations in Jakarta metropolitan area

    Institute of Scientific and Technical Information of China (English)

    Akira KONDO; Esrom HAMONANGAN; Satoshi SODA; Akikazu KAGA; Yoshio INOUE; Masaharu EGUCHI; Yuta YASAKA

    2007-01-01

    Total suspended particulate mater (TSP) concentrations were monitored for one year from July 2000 and for one year from April 2003 in Jakarta City. Thirteen elemental TSP components, aluminum (Al), sodium (Na), iron (Fe), lead (Pb), potassium (K), zinc (Zn), titanium (Ti), manganese (Mn), bromine (Br), copper (Cu), chromium (Cr), nickel (Ni), and vanadium (Ⅴ) were analyzed by a sequential X-ray fluorescence spectrometer. Al, Na, Fe, K, and Pb were major components at most of the sampling locations in 2000. However, only Pb in 2003 dramatically decreased to one tenth. The phase-out of leaded gasoline began on July 1, 2001 in Jakarta City and lead content in gasoline decreased to one tenth, too. The decrease in Pb concentration was a result of the phase-out of leaded gasoline, as lead emissions mainly are exhaust gas from vehicles.

  7. Impacts of converting from leaded to unleaded gasoline on ambient lead concentrations in Jakarta metropolitan area.

    Science.gov (United States)

    Kondo, Akira; Hamonangan, Esrom; Soda, Satoshi; Kaga, Akikazu; Inoue, Yoshio; Eguchi, Masaharu; Yasaka, Yuta

    2007-01-01

    Total suspended particulate mater (TSP) concentrations were monitored for one year from July 2000 and for one year from April 2003 in Jakarta City. Thirteen elemental TSP components, aluminum (Al), sodium (Na), iron (Fe), lead (Pb), potassium (K), zinc (Zn), titanium (Ti), manganese (Mn), bromine (Br), copper (Cu), chromium (Cr), nickel (Ni), and vanadium (V) were analyzed by a sequential X-ray fluorescence spectrometer. Al, Na, Fe, K, and Pb were major components at most of the sampling locations in 2000. However, only Pb in 2003 dramatically decreased to one tenth. The phase-out of leaded gasoline began on July 1, 2001 in Jakarta City and lead content in gasoline decreased to one tenth, too. The decrease in Pb concentration was a result of the phase-out of leaded gasoline, as lead emissions mainly are exhaust gas from vehicles.

  8. Cofilin takes the lead.

    Science.gov (United States)

    DesMarais, Vera; Ghosh, Mousumi; Eddy, Robert; Condeelis, John

    2005-01-01

    Cofilin has emerged as a key regulator of actin dynamics at the leading edge of motile cells. Through its actin-severing activity, it creates new actin barbed ends for polymerization and also depolymerizes old actin filaments. Its function is tightly regulated in the cell. Spatially, its activity is restricted by other actin-binding proteins, such as tropomyosin, which compete for accessibility of actin filament populations in different regions of the cell. At the molecular level, it is regulated by phosphorylation, pH and phosphatidylinositol (4,5)-bisphosphate binding downstream of signaling cascades. In addition, it also appears to be regulated by interactions with 14-3-3zeta and cyclase-associated protein. In vivo, cofilin acts synergistically with the Arp2/3 complex to amplify local actin polymerization responses upon cell stimulation, which gives it a central role in setting the direction of motility in crawling cells.

  9. Lead telluride alloy thermoelectrics

    Directory of Open Access Journals (Sweden)

    Aaron D. LaLonde

    2011-11-01

    Full Text Available The opportunity to use solid-state thermoelectrics for waste heat recovery has reinvigorated the field of thermoelectrics in tackling the challenges of energy sustainability. While thermoelectric generators have decades of proven reliability in space, from the 1960s to the present, terrestrial uses have so far been limited to niche applications on Earth because of a relatively low material efficiency. Lead telluride alloys were some of the first materials investigated and commercialized for generators but their full potential for thermoelectrics has only recently been revealed to be far greater than commonly believed. By reviewing some of the past and present successes of PbTe as a thermoelectric material we identify the issues for achieving maximum performance and successful band structure engineering strategies for further improvements that can be applied to other thermoelectric materials systems.

  10. Leading from the boardroom.

    Science.gov (United States)

    Lorsch, Jay W; Clark, Robert C

    2008-04-01

    These days, boards are working overtime to comply with Sarbanes-Oxley and other governance requirements meant to protect shareholders from executive wrongdoing. But as directors have become more hands-on with compliance, they've become more hands-off with long-range planning. That exposes corporations and their shareholders to another--perhaps even greater--risk, say professors Lorsch, of Harvard Business School, and Clark, of Harvard Law School. Boards are giving the long term short shrift for a number of reasons. Despite much heavier workloads, directors haven't rethought their patterns of operating - their meetings, committees, and other interactions. Compliance has changed their relationship with executives, however, turning directors into micromanagers who closely probe executives' actions instead of providing high-level guidance. Meanwhile, the pressure to meet quarterly expectations intensifies. Directors need to do a better job of balancing compliance with forward thinking. Boardroom effectiveness hinges most on the quality of directors and their interactions, the authors' research shows. Directors must apply their wisdom broadly, handling compliance work more efficiently and staying out of the weeds on strategic issues. Using their power with management to evangelize for long-term planning, they must take the lead on discussions about financial infrastructure, talent development, and strategy. Reserving sacrosanct time for such discussions, as Philips Electronics' board does at annual retreats, is an effective practice: After one recent retreat, Philips decided to exit the semiconductor business, where it was losing ground. Individual directors also must not shy away from asking tough questions and acting as catalysts on critical issues, such as grooming a successor to the CEO. In short, directors must learn to lead from the boardroom.

  11. Many Worlds, the Born Rule, and Self-Locating Uncertainty

    CERN Document Server

    Carroll, Sean M

    2014-01-01

    We provide a derivation of the Born Rule in the context of the Everett (Many-Worlds) approach to quantum mechanics. Our argument is based on the idea of self-locating uncertainty: in the period between the wave function branching via decoherence and an observer registering the outcome of the measurement, that observer can know the state of the universe precisely without knowing which branch they are on. We show that there is a uniquely rational way to apportion credence in such cases, which leads directly to the Born Rule. Our analysis generalizes straightforwardly to cases of combined classical and quantum self-locating uncertainty, as in the cosmological multiverse.

  12. Industrial dynamics beyond the lead firms

    DEFF Research Database (Denmark)

    Haakonsson, Stine Jessen; Slepniov, Dmitrij

    Since the turn of the millennium, China has developed into a core location for the wind energy industry and is today the largest market for wind turbines. These developments have caught attention among scholars. However, most research is on the development of the market and the lead firm strategies...... for market access or on innovation, capability building and technology transfer in the industry. The main objective of this paper is to look ‘beyond the lead firms’. We seek to advance the understanding of how the recent changes in the industry affect producers of key components and their role...... in the industry. The paper employs a qualitative methodology, which draws on explorative case studies of sub-suppliers in the wind turbine industry in China. A special empirical focus is on the first tier sub-suppliers. As the Western lead firms establish themselves in China, the sub-suppliers also have...

  13. Industrial Dynamics Beyond the Lead Firms

    DEFF Research Database (Denmark)

    Haakonsson, Stine Jessen; Slepniov, Dmitrij

    2013-01-01

    Since the turn of the millennium, China has developed into a core location for the wind energy industry and is today the largest market for wind turbines. These developments have caught attention among scholars. However, most research is on the development of the market and the lead firm strategies...... for market access or on innovation, capability building and technology transfer in the industry. The main objective of this paper is to look ‘beyond the lead firms’. We seek to advance the understanding of how the recent changes in the industry affect producers of key components and their role...... in the industry. The paper employs a qualitative methodology, which draws on explorative case studies of sub-suppliers in the wind turbine industry in China. A special empirical focus is on the first tier sub-suppliers. As the Western lead firms establish themselves in China, the sub-suppliers also have...

  14. Location of an intermediate hub for port activities

    Science.gov (United States)

    Burciu, Ş.; Ştefănică, C.; Roşca, E.; Dragu, V.; Ruscă, F.

    2015-11-01

    An intermediate hub might increase the accessibility level of ports but also hinterland and so it can be considered more than a facility with a transhipment role. These hubs might lead to the development of other transport services and enhance their role in gathering and covering economic centres within hinterlands and also getting the part of logistic facility for the ports, with effects on port utilization and its connectivity to global economy. A new location for a hub terminal leads to reduced transport distances within hinterland, with decreased transport costs and external effects, so with gains in people's life quality. Because the production and distribution systems are relatively fixed on short and medium term and the location decisions are strategic and on long term, the logistic chains activities location models have to consider the uncertainties regarding the possible future situations. In most models, production costs are considered equal, the location problem reducing itself to a problem that aims to minimize the total transport costs, meaning the transport problem. The main objective of the paper is to locate a hub terminal that links the producers of cereals that are going to be exported by naval transportation with the Romanian fluvial-maritime ports (Galaţi, Brăila). GIS environment can be used to integrate and analyse a great amount of data and has the ability of using functions as location - allocation models necessary both to private and public sector, being able to determine the optimal location for services like factories, warehouses, logistic platforms and other public services.

  15. Optimization of Microphone Locations for Acoustic Liner Impedance Eduction

    Science.gov (United States)

    Jones, M. G.; Watson, W. R.; June, J. C.

    2015-01-01

    Two impedance eduction methods are explored for use with data acquired in the NASA Langley Grazing Flow Impedance Tube. The first is an indirect method based on the convected Helmholtz equation, and the second is a direct method based on the Kumaresan and Tufts algorithm. Synthesized no-flow data, with random jitter to represent measurement error, are used to evaluate a number of possible microphone locations. Statistical approaches are used to evaluate the suitability of each set of microphone locations. Given the computational resources required, small sample statistics are employed for the indirect method. Since the direct method is much less computationally intensive, a Monte Carlo approach is employed to gather its statistics. A comparison of results achieved with full and reduced sets of microphone locations is used to determine which sets of microphone locations are acceptable. For the indirect method, each array that includes microphones in all three regions (upstream and downstream hard wall sections, and liner test section) provides acceptable results, even when as few as eight microphones are employed. The best arrays employ microphones well away from the leading and trailing edges of the liner. The direct method is constrained to use microphones opposite the liner. Although a number of arrays are acceptable, the optimum set employs 14 microphones positioned well away from the leading and trailing edges of the liner. The selected sets of microphone locations are also evaluated with data measured for ceramic tubular and perforate-over-honeycomb liners at three flow conditions (Mach 0.0, 0.3, and 0.5). They compare favorably with results attained using all 53 microphone locations. Although different optimum microphone locations are selected for the two impedance eduction methods, there is significant overlap. Thus, the union of these two microphone arrays is preferred, as it supports usage of both methods. This array contains 3 microphones in the upstream

  16. TAGGING, TRACKING AND LOCATING WITHOUT GPS

    Energy Technology Data Exchange (ETDEWEB)

    Cordaro, J.; Coleman, T.; Shull, D.

    2012-07-08

    The Savannah River National Laboratory (SRNL) was requested to lead a Law Enforcement Working Group that was formed to collaborate on common operational needs. All agencies represented on the working group ranked their need to tag, track, and locate a witting or unwitting target as their highest priority. Specifically, they were looking for technologies more robust than Global Positioning Satellite (GPS), could communicate back to the owner, and worked where normal cell phone communications did not work or were unreliable. SRNL brought together multiple technologies in a demonstration that was held in in various Alaska venues, including metropolitan, wilderness, and at-sea that met the working group's requirements. Using prototypical technologies from Boeing, On Ramp, and Fortress, SRNL was able to demonstrate the ability to track personnel and material in all scenarios including indoors, in heavily wooden areas, canyons, and in parking garages. In all cases GPS signals were too weak to measure. Bi-directional communication was achieved in areas that Wi-Fi, cell towers, or traditional radios would not perform. The results of the exercise will be presented. These technologies are considered ideal for tracking high value material such has nuclear material with a platform that allows seamless tracking anywhere in the world, indoors or outdoors.

  17. Mining significant semantic locations from GPS data

    DEFF Research Database (Denmark)

    Cao, Xin; Cong, Gao; Jensen, Christian S.

    2010-01-01

    With the increasing deployment and use of GPS-enabled devices, massive amounts of GPS data are becoming available. We propose a general framework for the mining of semantically meaningful, significant locations, e.g., shopping malls and restaurants, from such data. We present techniques capable...... of extracting semantic locations from GPS data. We capture the relationships between locations and between locations and users with a graph. Significance is then assigned to locations using random walks over the graph that propagates significance among the locations. In doing so, mutual reinforcement between...

  18. Mining significant semantic locations from GPS data

    DEFF Research Database (Denmark)

    Cao, Xin; Cong, Gao; Jensen, Christian S.

    2010-01-01

    With the increasing deployment and use of GPS-enabled devices, massive amounts of GPS data are becoming available. We propose a general framework for the mining of semantically meaningful, significant locations, e.g., shopping malls and restaurants, from such data. We present techniques capable...... of extracting semantic locations from GPS data. We capture the relationships between locations and between locations and users with a graph. Significance is then assigned to locations using random walks over the graph that propagates significance among the locations. In doing so, mutual reinforcement between...

  19. Bounds in the location-allocation problem

    DEFF Research Database (Denmark)

    Juel, Henrik

    1981-01-01

    Develops a family of stronger lower bounds on the objective function value of the location-allocation problem. Solution methods proposed to solve problems in location-allocation; Efforts to develop a more efficient bound solution procedure; Determination of the locations of the sources.......Develops a family of stronger lower bounds on the objective function value of the location-allocation problem. Solution methods proposed to solve problems in location-allocation; Efforts to develop a more efficient bound solution procedure; Determination of the locations of the sources....

  20. Location Privacy Protection on Social Networks

    Science.gov (United States)

    Zhan, Justin; Fang, Xing

    Location information is considered as private in many scenarios. Protecting location information on mobile ad-hoc networks has attracted much research in past years. However, location information protection on social networks has not been paid much attention. In this paper, we present a novel location privacy protection approach on the basis of user messages in social networks. Our approach grants flexibility to users by offering them multiple protecting options. To the best of our knowledge, this is the first attempt to protect social network users' location information via text messages. We propose five algorithms for location privacy protection on social networks.

  1. Echocardiographic mapping of left ventricular resynchronization during cardiac resynchronization therapy procedures

    Institute of Scientific and Technical Information of China (English)

    CHAN Ngai-yin; CHOY Chi-chung; CHEUNG Kar-chun; LAU Chun-leung; LO Ying-keung; CHU Pui-shan; YUEN Ho-chuen; LAU Suet-ting; CHOI Yuen-choi

    2010-01-01

    Background Cardiac resynchronization therapy (CRT) is an effective electrical therapy for patients with moderate to severe heart failure and cardiac dyssynchrony. This study aimed to investigate the degree of acute left ventricular (LV)resynchronization with biventricular pacing (BVP) at different LV sites and to examine the feasibility of performing transthoracic echocardiography (TTE) to quantify acute LV resynchronization during CRT procedure.Methods Fourteen patients with NYHA Class ⅢⅣ heart failure, LV ejection fraction ≤35%, QRS duration ≥120 ms and septal-lateral delay (SLD) ≥60 ms on tissue Doppler imaging (TDI), underwent CRT implant. TDI was obtained from three apical views during BVP at each accessible LV site and SLD during BVP was derived. Synchronicity gain index (Sg) by SLD was defined as (1+(SLD at baseline - SLD at BVP)/SLD at baseline).Results Seventy-two sites were studied. Positive resynchronization (R+, Sg>1) was found in 42 (58%) sites. R+ was more likely in posterior or lateral than anterior LV sites (66% vs. 36%, P <0.001). Concordance of empirical LV lead implantation sites and sites with R+ was 50% (7/14).Conclusions The degree of acute LV resynchronization by BVP depends on LV lead location and empirical implantation of LV lead results in only 50% concordance with R+. Performing TTE during CRT implantation is feasible to identify LV sites with positive resynchronization.

  2. Polymorphism of lead oxoborate

    Energy Technology Data Exchange (ETDEWEB)

    Tyulyupa, A.G. [Middle School, Sablinskoe, Stavropol region, 356322 (Russian Federation); Voronov, V.V. [A.M. Prokhorov General Physics Institute RAS, 38 Vavilov Street, Moscow 119991 (Russian Federation); Fedorov, P.P., E-mail: ppfedorov@yandex.ru [A.M. Prokhorov General Physics Institute RAS, 38 Vavilov Street, Moscow 119991 (Russian Federation)

    2015-07-20

    Highlights: • Pb{sub 4}B{sub 2}O{sub 7} melt undergoes statistical undercooling. • Orthorhombic nonlinear optical crystal Pb{sub 4}O(BO{sub 3}){sub 2} is the metastable γ-polymorph. • Temperature of metastable melting of γ-Pb{sub 4}O(BO{sub 3}){sub 2} is equal to 530 °C. - Abstract: The study of lead borate melt crystallization by differential thermal analysis (DTA) and X-ray diffraction analysis has shown that, for Pb{sub 4}O(BO{sub 3}){sub 2} (or 4PbO·B{sub 2}O{sub 3}) stoichiometric compound, its well-known orthorhombic modification (non-centrosymmetric Aba2 space symmetry group (SSG), a = 15.472(1), b = 10.802(1), c = 9.9486(6) Å unit cell parameters) is metastable. It forms from the undercooled melt and has a melting point of 530 ± 5 °C.

  3. Drowning: a leading killer!

    Directory of Open Access Journals (Sweden)

    Nuno Domingos Garrido

    2016-10-01

    Full Text Available Drowning kills at least 372,000 people worldwide every year and is the 3rd leading cause of unintentional death, accounting for 7% of all deaths stemming from accidents (WHO, 2014. Conceptually, “drowning” is a complex and multi-faceted phenomenon, characterized as a chain of events (Bierens, 2006. Drowning is defined as the process of experiencing respiratory impairment from immersion or submersion in liquid. Research on drowning as a phenomenon presents several difficulties - most of all, that global data concerning the number of occurrences are not accurate. Nevertheless, detailed analysis of the registered incidents allows the identification of risk factors of drowning. An in-depth analysis of the risk factors is the basis for the creation of targeted and effective strategies to prevent drowning. Due to variability of situations which could lead to a drowning episode, experts suggest the adoption of a multi-layer prevention model, rather than opting for isolated measures, since no single measure can prevent all deaths and injuries caused by submersion. Among the preventive measures we would like to emphasize instruction in swimming and water safety. So, what does "knowing how to swim" really mean? Some authors define mastery of this competence as swimming a given distance, while others put the emphasis on how this/any given distance is swum (Stallman, Junge, & Blixt, 2008. It has long been realized that there is no contradiction between learning those competencies which make a person less susceptible to drowning and those competencies which prepare the path towards higher levels of performance and competition. Aquatic movement researchers and practitioners and drowning prevention researchers and practitioners, share in the responsibility for drowning prevention though they are often unaware of it. The question “What should be taught to children?” is too infrequently asked. There remains great variation in what is taught and programs

  4. Leading Your Leaders

    Science.gov (United States)

    Hale, Wayne N.

    2008-01-01

    life is good. More often when an unbelievably difficult test fails, we are left with a very long discussion of why and what was wrong in the design or execution of the test. Make sure that the test is well defined. Even then, it is important to explain to your leaders what inherent accuracy (or error) the test conditions or equipment have and what the assumptions or initial conditions were for the test. Test results without a good understanding of the test's accuracy or the pedigree of the test assumptions are worth very little. Finally, there is flight test data. Always limited, never at the edge of the envelope, it still shows how the real hardware works in a combined environment. Flight experience is dangerous because it typically doesn't show how close to the edge of the cliff the equipment is operating, but it does demonstrate how the hardware really works. A flight test is the ultimate test, again taken with the knowledge that it is probably not the extreme but something more like the middle of the environmental and systems performance. Good understanding of a problem and its solution always relies on a combination of all these methods. Be sure to lead your leaders by using all the tools you have at your disposal. At the end of the day, decisions in space flight always come down to a risk trade. Our business is not remotely safe, not in the sense that the public, the media, or our legislators use the term. Everything we do has a risk, cost, schedule, or performance trade-off. For your leaders to make an appropriate decision, you need to educate them, lead them, talk with them, and engage them in the discussion until full understanding takes place. It's your job. *

  5. HSIP Law Enforcement Locations in New Mexico

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Law Enforcement Locations Any location where sworn officers of a law enforcement agency are regularly based or stationed. Law Enforcement agencies "are publicly...

  6. Recycling Facilities - Land Recycling Cleanup Locations

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Land Recycling Cleanup Location Land Recycling Cleanup Locations (LRCL) are divided into one or more sub-facilities categorized as media: Air, Contained Release or...

  7. National Archives and Records Administration Employee Locator

    Data.gov (United States)

    National Archives and Records Administration — The National Archives and Records Administration Employee Locator is an online system that provides the name, office symbol, location, room, telephone number, and...

  8. Recycling Facilities - Land Recycling Cleanup Locations

    Data.gov (United States)

    NSGIC Education | GIS Inventory — Land Recycling Cleanup Location Land Recycling Cleanup Locations (LRCL) are divided into one or more sub-facilities categorized as media: Air, Contained Release or...

  9. Secondary Lesson Plan: Place and Relative Location.

    Science.gov (United States)

    Crawford, John

    1989-01-01

    Presents a secondary education geography lesson plan for teaching the theme of place and relative location. Provides samples of student materials. Using Japan as an example, shows how place and relative location can be used to study a country. (KO)

  10. Lead Toxicity Risks in Gunshot Victims.

    Directory of Open Access Journals (Sweden)

    Gabriel Costa Serrão de Araújo

    Full Text Available Gunshot wounds require surgeons to decide whether to remove or leave bullet fragments in the body. Surgeons also decide how to follow up with patients who have lead fragments retained in their body. Current literature recommends to remove only intra-articular fragments without the need for a follow-up for patients with the metal retained. Therefore, this study investigates chronic lead toxicity for gunshot wounds.The study was performed in the metropolitan area of Rio de Janeiro/Brazil, between 2013 and 2015. It was a case-control study that included 45 victims of gunshot lesions with metallic fragments retained for more than 6 months. The 45 controls were matched for gender, age, and race. We compared the lead blood levels and frequency of symptoms.The control group had average blood lead levels of 2.17 μg/dL (95% Confidence Interval [CI]; 1.71-2.63 and median 2.1 μg/dL. The case group had average values of 9.01 μg/dL (CI; 6.07-11.96 and median values of 6.5 μg/dL with p-values < = 0.001. The case group reported the following more frequently: irritancy, bad mood, headache, memory losses, daylight drowsiness, myalgia, weakness, abdominal pain, joint pain, trembling, tingling limbs. There was statistical significance for the differences of symptoms frequencies and for odds ratio between groups.Although the mean lead levels found were lower than the current laboratory references, low levels have been associated with both rising morbidity and mortality. The WHO stated: "There is no known level of lead exposure that is considered safe". In conclusion, this work showed that bullets retained in the body are not innocuous. There are impacts in the blood lead levels and symptoms related to it, even with few fragments, extra-articular located or existing with low blood lead levels.

  11. Indoor location estimation using radio beacons

    Science.gov (United States)

    Ahmad, Uzair; Lee, Young-Koo; Lee, Sungyoug; Park, Chongkug

    2007-12-01

    We present a simple location estimation method for developing radio beacon based location system in the indoor environments. It employs an online learning approach for making large scale location systems in a short time collaboratively. The salient features of our method are low memory requirements and simple computations which make it suitable for both distributed location-aware applications based on client-server model as well as privacy sensitive applications residing on stand alone devices.

  12. The Development of Locative Comprehension in Spanish.

    Science.gov (United States)

    Connor, Peggy S.; Chapman, Robin S.

    1985-01-01

    Describes a study of 40 monolingual Spanish-speaking Peruvian children in which comprehension of six locative phrases was tested. Results are analyzed in terms of developmental sequence, locative acquisition, the effects of intrinsic label on projective locative comprehension, the effects of linguistic form, and the effects of context. (SED)

  13. Finding dense locations in indoor tracking data

    DEFF Research Database (Denmark)

    Ahmed, Tanvir; Pedersen, Torben Bach; Lu, Hua

    2014-01-01

    Finding the dense locations in large indoor spaces is very useful for getting overloaded locations, security, crowd management, indoor navigation, and guidance. Indoor tracking data can be very large and are not readily available for finding dense locations. This paper presents a graph-based mode...

  14. Multi-dimensional indoor location information model

    NARCIS (Netherlands)

    Xiong, Q.; Zhu, Q.; Zlatanova, S.; Huang, L.; Zhou, Y.; Du, Z.

    2013-01-01

    Aiming at the increasing requirements of seamless indoor and outdoor navigation and location service, a Chinese standard of Multidimensional Indoor Location Information Model is being developed, which defines ontology of indoor location. The model is complementary to 3D concepts like CityGML and

  15. Open Location Management in Automated Warehousing Systems

    NARCIS (Netherlands)

    Y. Yu (Yugang); M.B.M. de Koster (René)

    2009-01-01

    textabstractA warehouse needs to have sufficient open locations to be able to store incoming shipments of various sizes. In combination with ongoing load retrievals open locations gradually spread over the storage area. Unfavorable positions of open locations negatively impact the average load retri

  16. Checking in: Location Services for Libraries

    Science.gov (United States)

    Rethlefsen, Melissa L.

    2010-01-01

    As always in real estate, everything in technology these days seems to be about location. From Google's recent addition of a "nearby" location limit to its suite of search options to the spate of location-based mobile apps and social networks, physical proximity has become the linchpin of a trend to connect technology to the real world. In this…

  17. Bounds in the location-allocation problem

    DEFF Research Database (Denmark)

    Juel, Henrik

    1981-01-01

    Develops a family of stronger lower bounds on the objective function value of the location-allocation problem. Solution methods proposed to solve problems in location-allocation; Efforts to develop a more efficient bound solution procedure; Determination of the locations of the sources....

  18. Heilongjiang discovered a number of non ferrous metal mineral locations

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>Non-ferrous Metal Geological Exploration Bu- reau of Heilongjiang Province achieved signifi- cant mine searching results in 2007:estimation and forecast of resource reserves covered 60,000 tons of Molybdenum,70,000 tons of copper,9 million tons of iron,2.9 tons of gold, 250 tons of silver,and 80,000 tons of lead and zinc.Newly discovered metal mine locations

  19. Current issues in human lead exposure and regulation of lead.

    Science.gov (United States)

    Davis, J M; Elias, R W; Grant, L D

    1993-01-01

    Concern about lead as a significant public health problem has increased as epidemiological and experimental evidence has mounted regarding adverse health effects at successively lower levels of lead exposure. This concern has led to downward revision of criteria for acceptable blood lead concentrations to the 10 micrograms/dL mark now designated by EPA as a target level for regulatory development and enforcement/clean-up purposes. Much progress has been made in reducing lead exposures during the past 10-15 years, with marked declines evident both in air lead and blood lead concentrations in parallel to the phase-down of lead in gasoline and notable decreases in food lead exposure due to elimination of lead soldered cans by U.S. food processors. With the lessening of exposure from these sources, the importance of other components of multimedia exposure pathways has grown and stimulated increasing regulatory attention and abatement efforts to reduce health risks associated with lead exposure from drinking water, from lead-based paint, and from household dust and soil contaminated by deteriorating paint, smelter emissions, or various other sources. Increasing attention is also being accorded to reduction of occupational lead exposures (including those related to lead abatement activities), with particular concern for protection of men and women during their reproductive years.

  20. Optimal Locations of Bus Stops Connecting Subways near Urban Intersections

    Directory of Open Access Journals (Sweden)

    Yuan Cui

    2015-01-01

    Full Text Available Unsuitable locations of bus stops which provide feeder transportation connecting subways near urban intersections usually lead to the low efficiency of public transport and level of passenger service. A multiobjective optimization model to distribute such stop locations is proposed to attain the shortest total walk distance of passengers and minimum delay time of cars through intersections and travel time of buses. The Pareto frontier and optimal solutions for the proposed model are given by the distance-based and enumerative methods. The Xizhimen bus stop is selected to implement case studies for verifying the validity of the proposed model. The analysis of sensitivity on possible solutions is also carried out in the case studies. The results show that the proposed model is capable of optimizing the locations of bus stops connecting subways near intersections and helpful to improve the level of passengers service and operational efficiency of public transportation.

  1. Wireless location technology and its application

    Institute of Scientific and Technical Information of China (English)

    Zhao Junhui; Wang Dongming

    2011-01-01

    Wireless location technology is used to locate, track and monitor the location of given target using devices such as the radio frequency identification (RFID) based on WiFi technology and the sensors. And such applications as long term evolution (LTE), wireless local area networks (WLAN), RFID and location based service (LBS) are essential in today' s wireless communications industry. In this paper, both wireless location technology and its application are proposed, where our experimental research results and theoretical innovation are included.

  2. [Rare location of arachnoid cysts. Extratemporal cysts].

    Science.gov (United States)

    Martinez-Perez, Rafael; Hinojosa, José; Pascual, Beatriz; Panaderos, Teresa; Welter, Diego; Muñoz, María J

    2016-01-01

    The therapeutic management of arachnoid cysts depends largely on its location. Almost 50% of arachnoid cysts are located in the temporal fossa-Sylvian fissure, whereas the other half is distributed in different locations, sometimes exceptional. Under the name of infrequent location arachnoid cysts, a description is presented of those composed of 2 sheets of arachnoid membrane, which are not located in the temporal fossa, and are primary or congenital. Copyright © 2015 Sociedad Española de Neurocirugía. Published by Elsevier España. All rights reserved.

  3. Blood lead levels in children and environmental lead contamination in Miami inner city, Florida.

    Science.gov (United States)

    Gasana, Janvier; Hlaing, WayWay M; Siegel, Kristy A; Chamorro, Armando; Niyonsenga, Theophile

    2006-09-01

    Studies have shown that the environmental conditions of the home are important predictors of health, especially in low-income communities. Understanding the relationship between the environment and health is crucial in the management of certain diseases. One health outcome related to the home environment among urban, minority, and low-income children is childhood lead poisoning. The most common sources of lead exposure for children are lead paint in older, dilapidated housing and contaminated dust and soil produced by accumulated residue of leaded gasoline. Blood lead levels (BLL) as low as 10 microg/dL in children are associated with impaired cognitive function, behavior difficulties, and reduced intelligence. Recently, it is suggested that the standard for intervention be lowered to BLL of 5 microg/dl. The objectives of our report were to assess the prevalence of lead poisoning among children under six years of age and to quantify and test the correlations between BLL in children and lead exposure levels in their environment. This cross-sectional analysis was restricted to 75 children under six years of age who lived in 6 zip code areas of inner city Miami. These locations exhibited unacceptably high levels of lead dust and soil in areas where children live and play. Using the 5 microg/dL as the cutoff point, the prevalence of lead poisoning among the study sample was 13.33%. The study revealed that lead levels in floor dust and window sill samples were positively and significantly correlated with BLL among children (p air, and water samples were not significant. Based on this pilot study, a more comprehensive environmental study in surrounding inner city areas is warranted. Parental education on proper housecleaning techniques may also benefit those living in the high lead-exposed communities of inner city Miami.

  4. Blood Lead Levels in Children and Environmental Lead Contamination in Miami Inner City, Florida

    Directory of Open Access Journals (Sweden)

    Theophile Niyonsenga

    2006-09-01

    Full Text Available Studies have shown that the environmental conditions of the home are important predictors of health, especially in low-income communities. Understanding the relationship between the environment and health is crucial in the management of certain diseases. One health outcome related to the home environment among urban, minority, and low-income children is childhood lead poisoning. The most common sources of lead exposure for children are lead paint in older, dilapidated housing and contaminated dust and soil produced by accumulated residue of leaded gasoline. Blood lead levels (BLL as low as 10 μg/dL in children are associated with impaired cognitive function, behavior difficulties, and reduced intelligence. Recently, it is suggested that the standard for intervention be lowered to BLL of 5 μg /dl. The objectives of our report were to assess the prevalence of lead poisoning among children under six years of age and to quantify and test the correlations between BLL in children and lead exposure levels in their environment. This cross-sectional analysis was restricted to 75 children under six years of age who lived in 6 zip code areas of inner city Miami. These locations exhibited unacceptably high levels of lead dust and soil in areas where children live and play. Using the 5 μg/dL as the cutoff point, the prevalence of lead poisoning among the study sample was 13.33%. The study revealed that lead levels in floor dust and window sill samples were positively and significantly correlated with BLL among children (p < 0.05. However, the correlations between BLL and the soil, air, and water samples were not significant. Based on this pilot study, a more comprehensive environmental study in surrounding inner city areas is warranted. Parental education on proper housecleaning techniques may also benefit those living in the high lead-exposed communities of inner city Miami.

  5. Location perception: the X-Files parable.

    Science.gov (United States)

    Prinzmetal, William

    2005-01-01

    Three aspects of visual object location were investigated: (1) how the visual system integrates information for locating objects, (2) how attention operates to affect location perception, and (3) how the visual system deals with locating an object when multiple objects are present. The theories were described in terms of a parable (the X-Files parable). Then, computer simulations were developed. Finally, predictions derived from the simulations were tested. In the scenario described in the parable, we ask how a system of detectors might locate an alien spaceship, how attention might be implemented in such a spaceship detection system, and how the presence of one spaceship might influence the location perception of another alien spaceship. Experiment 1 demonstrated that location information is integrated with a spatial average rule. In Experiment 2, this rule was applied to a more-samples theory of attention. Experiment 3 demonstrated how the integration rule could account for various visual illusions.

  6. Concentration Mechanism of Ore-Forming Fluid in Huize Lead-Zinc Deposits, Yunnan Province

    Institute of Scientific and Technical Information of China (English)

    Zhang Zhenliang; Huang Zhilong; Rao Bing; Guan Tao; Yan Zaifei

    2005-01-01

    The Huize Pb-Zn deposits of Yunnan Province, located in the south-central part of the Sichuan-Yunnan-Guizhou (SYG) Pb-Zn multimetal mineralization district (MMD), are strictly controlled by fault zones. The sources of ore-forming fluid in the deposits have been debated for a long time. Calcite, a gangue mineral, has uniform C and O isotopes. The δ13CPDB and δ18OSMOW values vary respectively from -2.1×10-3 to -3.5×10-3 (mean -2.8×10-3) and 16.7×10-3-18.6×10-3 (mean 17.7×10-3). No obvious difference can be found in C and O isotopes among occurrences and elevations and even ore-bodies. Types of inclusions include those of pure liquid (L), liquid-rich gas-liquid (L+V), and three-phase ones containing a daughter mineral (S+L+V) and immiscible CO2 with three-phases (VCO2+LCO2+LH2O). Their homogenization temperatures vary from 110 to 400 ℃, and two peaks are shown. (87Sr/86Sr)0 ratios of calcite in the deposits are higher than those in the mantle and Emeishan basalts, and slightly higher than those in the Baizuo Formation, which the Huize lead-zinc deposits are found in. All of the (87Sr/86Sr)0 are low relative to those in the basement rocks. Fractionation of Sr isotope did not occur in the ore-forming fluid during the precipitation of minerals. The results indicate that the ore-forming fluid is homogeneous and derived from the mixing of different fluids. Gas-liquid inclusions can be separated into two groups in 300-400 ℃ with a salinity of 5 %-6 % and 12 %-16 % NaCl respectively. However, the salinities of inclusions vary from 7 % to 23 % NaCl in 100-300 ℃, especially in 150-250 ℃. The formation pressures of faulted zones are (50-320)×105 Pa. The estimated pressures of the overlying rocks on the ore bodies are 574×105-640×105 Pa. The pressures of ore-forming processes would be 145×105 to 754×105 Pa. Therefore, pressure sharply reduced and boiling occurred when the ore-forming fluid flew into the fault zones. As a result, the ore-forming fluid was

  7. Location decision strategies for improving SMME business performance

    Directory of Open Access Journals (Sweden)

    Shereen Barnard

    2011-12-01

    relationship between electricity tariffs and business performance. Employment and business performance attained the strongest positive relationship; indicating that business owners regarded employment as an important factor to consider when searching for suitable business premises. The relationship between location and business performance obtained the lowest positive correlation. Originality and value of the research: Research on South African SMMEs regarding location decisions and the specific factors identified in this study has not been done previously in South Africa. Therefore, because evidence exists that the macro-environmental factors influence location decisions to varying degrees, this study can provide SMME owners with insight into the factors influencing location choice. It is vital that business owners consider these factors as they could influence business performance, and ultimately, business survival. An increased awareness of the importance of the aspects discussed in this study could consequently lead to improved performance in the SMME sector.

  8. On Preventing Location Attacks for Urban Vehicular Networks

    Directory of Open Access Journals (Sweden)

    Meng Zhou

    2016-01-01

    Full Text Available The prevalence of global positioning system (GPS equipped in vehicular networks exposes users’ location information to the location-based services. We argue that such data contains rich informative cues on drivers’ private behaviors and preferences, which will lead to the location privacy attacks. In this paper, we proposed a sophisticated prediction model to predict driver’s next location by using a k-order Markov chain-based third-rank tensor representing the partially observed transfer information of vehicles. Then Bayesian Personalized Ranking (BPR is used to learn the unobserved transitions within the tensor for transition predication. Experimental results manifest the efficacy of the proposed model in terms of location predication accuracy, compared with several state-of-the-art predication methods. We also point out that the precision achieved by such advanced predication model is restricted to the order of the Markov chain k. Accordingly, we propose a schema to decrease the risks of such attacks by preventing the conformation of higher order Markov chain. Experimental results obtained based on the real-world vehicular network data demonstrated the effectiveness of our proposed schema.

  9. Quantitative analysis of cardiac function: Comparison of electrocardiogram dual gated single photon emission tomography, planar radionuclide ventriculogram and contrast ventriculography in the determination of LV volume and ejection fraction

    Energy Technology Data Exchange (ETDEWEB)

    Ziada, G.; Abdel-Dayem, H.M.; Higazy, E.; Mohamed, M.M.; Bahar, R.; Hayat, N.; Yousof, A.M.

    1987-03-01

    A dual gated tomography (DGT) program for end systolic and end diastolic acquisition and subsequent processing for calculation of LVEF, end diastolic and end systolic volumes (EDV, ESV) has been evaluated in 20 healthy volunteers (25 years-40 years) and 45 patients (25 years-60 years): 20 with ischaemic heart disease and 25 with valvular heart disease (VHD). All had biplane multigated blood pool (MUGA) studies in the 40/sup 0/ LAO projection using in vivo /sup 99m/Tc-R BCs, immediately followed by DG. The results in the patients group were correlated with contrast ventriculography (CV). In the volunteer group, the normal values for LVEF, EDV and ESV measured with DGT were found to be 63%+10%, 91 ml + 6 ml and 30 ml + 6ml and r value for the LVEF=0.91 compared with MUGA. In the IHD group, r values compared with CV were 0.915 and 0.97 for the EDV and ESV and 0.934 for the LVEF. Compared with the MUGA, the r value for LVEF was 0.883. In the VHD group, r values were 0.98 for both the EDV and ESV and 0.948 for the LVEF (P<0.002) compared with CV and 0.789 for the LVEF compared with the MUGA. We feel that DGT is an accurate and reproducible technique for LV function measurements.

  10. The Transformation of the Roles of Intellectual Women in Modern China——Taking Lv Bicheng for Example%中国知识女性角色的近代转型——以吕碧城为例

    Institute of Scientific and Technical Information of China (English)

    池子华; 庞向南

    2011-01-01

    This paper is a study of intellectual women of modern China.By taking Lv Bicheng as an example,disserting her concept and practice from the perspective of social cultural history.It shows the transformation from her views to her practice.And then we can explore the process from ignorance to awakening of modern intellectual women,and reveal the features and achievements of Chinese feminist movement in certain historical background.%以中国近代的知识女性作为研究对象,以吕碧城为个案,从社会文化史角度对其思想观念和实践进行论述,展示其从思想到行动的转变轨迹,可以探寻近代知识女性从蒙昧到觉醒的变迁,揭示在特定历史背景下中国妇女运动的特点与成果。

  11. The Changing Way of Leading

    Science.gov (United States)

    Sytsma, Sandra

    2009-01-01

    This conceptual article explores the changing way of leading. It proposes that in contrast to the primarily outer actions that characterize educational change, the inner and outer dimensions of leaders are necessary to change what constitutes leading, thereby making it more appropriate to our times. The unfolding of leading actions and the…

  12. Lead in School Drinking Water.

    Science.gov (United States)

    Environmental Protection Agency, Washington, DC. Office of Water Programs.

    Lead levels in school drinking water merit special concern because children are more at risk than adults from exposure to lead. This manual provides ways in which school officials can minimize this risk. It assists administrators by providing: (1) general information on the significance of lead in school drinking water and its effects on children;…

  13. The origin of the ie endingless locative

    Directory of Open Access Journals (Sweden)

    Kenneth Shields

    1979-12-01

    Full Text Available In this paper is presented a new hypothesis regarding the development of the so-called "endingless locative" construction of Indo-European. It is argued that locative formations in -ē, and * ī came to appear in the , o-stem nouns through the monophthongization of word-final *-oi and *-ei before word-initial consonants. These formations were analogically extended to the other stem-classes, with the suffix*-ē, frequently hypercharacterized by the locative particles *-i or *-u, becoming the primary marker of the locative function in the i- and u-stems. On the basis of such apparently "endingless" locative constructions, old consonant-stem nominative (-accusative formations in were reinterpreted as locatives as well.

  14. Allocation and Location of Transport Logistics Centres

    Directory of Open Access Journals (Sweden)

    D. Mocková

    2010-01-01

    Full Text Available The facility allocation problem sets out to determine the optimal number of facilities to be opened. Based on multiple criteria evaluation, the optimal location of the facilities is usually solved subsequently. Several considerations, e.g. technical parameters, costs and finance must be taken into account. Economic analysis is carried out on the basis of the specific instance of the problem.Let us assume that the number of potentially located facilities is known. Then the problem of the optimal location of a given number of facilities in a network is referred to as the facility location problem. The solution to the problem is a set of facilities optimally located in an area such that this area is fully covered by the required services that the facilities provide. An example of a real-life problem of this type is the location of logistics centers. 

  15. LOCATORS OPTIMIZATION FOR MEASURING FIXTURE DESIGN

    Institute of Scientific and Technical Information of China (English)

    Wang Jian; Zhou Jiangqi; Lin Zhongqin

    2004-01-01

    "N-2-1" principle is widely recognized in the fixture design for deformable sheet metal workpieces, where N, the locators on primary datum, is the key to sheet metal fixture design. However, little research is done on how to determine the positions and the number of N locators. In practice, the N locators are frequently designed from experience, which is often unsatisfactory for achieving the precision requirement in fixture design. A new method to lay out the N locators for measuring fixture of deformable sheet metal workpiece is presented, given the fixed number of N. Finite-element method is used to model and analysis the deformation of different locator layouts. A knowledge based genetic algorithm (KBGA) is applied to identify the optimum locator layout for measuring fixture design. An example of a door outer is used to verify the optimization approach.

  16. Lead exposure among lead-acid battery workers in Jamaica.

    Science.gov (United States)

    Matte, T D; Figueroa, J P; Burr, G; Flesch, J P; Keenlyside, R A; Baker, E L

    1989-01-01

    To assess lead exposure in the Jamaican lead-acid battery industry, we surveyed three battery manufacturers (including 46 production workers) and 10 battery repair shops (including 23 battery repair workers). Engineering controls and respiratory protection were judged to be inadequate at battery manufacturers and battery repair shops. At manufacturers, 38 of 42 air samples for lead exceeded a work-shift time-weighted average concentration of 0.050 mg/m3 (range 0.030-5.3 mg/m3), and nine samples exceeded 0.50 mg/m3. Only one of seven air samples at repair shops exceeded 0.050 mg/m3 (range 0.003-0.066 mg/m3). Repair shop workers, however, had higher blood lead levels than manufacturing workers (65% vs. 28% with blood lead levels above 60 micrograms/dl, respectively). Manufacturing workers had a higher prevalence of safe hygienic practices and a recent interval of minimal production had occurred at one of the battery manufacturers. Workers with blood lead levels above 60 micrograms/dl tended to have higher prevalences of most symptoms of lead toxicity than did workers with lower blood lead levels, but this finding was not consistent or statistically significant. The relationship between zinc protoporphyrin concentrations and increasing blood lead concentrations was consistent with that described among workers in developed countries. The high risk of lead toxicity among Jamaican battery workers is consistent with studies of battery workers in other developing countries.

  17. LES INVERSIONS LOCATIVES DANS "LA JALOUSIE"

    OpenAIRE

    Fuchs, Catherine; Le Goffic, Pierre

    2016-01-01

    International audience; Chapter 4 is devoted to a linguistic analysis of the 47 examples of locative inversions which are to be found in Robbe-Grillet's novel La Jalousie. We successively consider the ordering, the internal structure, the lexical characteristics and the determiners of the three main constituents (namely the Location Phrase, the Verbal Phrase and the nominal Subject Phrase). The analysis enlightens the non prototypical way in which the author uses locative inversion structures...

  18. Environmental Regulation and Industry Location in Europe

    OpenAIRE

    2010-01-01

    This paper estimates the effect of environmental regulation on industry location and compares it with other determinants of location such as agricultural, education and R&D country characteristics. The analysis is based on a general empirical trade model that captures the interaction between country and industry characteristics in determining industry location. The Johnson-Neyman technique is used to fully explicate the nature of the conditional interactions. The model is applied to data on 1...

  19. Location Privacy Issues in Wireless Sensor Networks

    Science.gov (United States)

    Kůr, Jiří; Stetsko, Andriy

    We discuss location privacy issues in wireless sensor networks. We consider sensor nodes with more responsible roles and the need to protect locations of such nodes. Available countermeasures against various types of traffic analysis attacks are examined and their problems are identified. We do not propose new traffic analysis resistance technique. Instead, we draw attention to blanks in current situation and identify several open questions, which should be answered in order to ensure location privacy of nodes.

  20. Location Awareness in a Mountain Rescue Domain

    OpenAIRE

    Georgopoulos, Panagiotis; Edwards, Christopher; Dunmore, Martin

    2008-01-01

    Aiding the efficient collaboration and coordination of rescue teams is a challenging task especially in a heterogeneous mountainous region. Knowing the exact location of the rescuers during a mountain search and rescue mission can be of great value for the successful progress of the mission and help the mission coordinator in taking informed decisions. The devised Location Awareness System can provide, in a quasi real time manner, exact location information of the rescuers on the mountain, to...

  1. Facilitating location independence with computerized conversation systems

    OpenAIRE

    E J Menasse Noble; J.; Adler

    1996-01-01

    Location independence for organizations is desirable if they wish to achieve a given spatial distribution in a regional development plan. An organization's interaction with its environment forms the basis of its daily work and takes the form of 'information links' composed of fundamental indivisible blocks called 'conversations'. To achieve location independence it is necessary for organizations to develop and maintain environment interactions independent of their location. Information techno...

  2. Hydatid Disease Located in the Cerebellomedullary Cistern

    Directory of Open Access Journals (Sweden)

    Özgür Kızılca

    2014-01-01

    Full Text Available Hydatid disease is an endemic zoonotic disease in many areas of the world. Liver, followed by lung, is the most commonly affected organ and involvement of other organs is rare. When brain is involved, lesions are typically supratentorial, and infratentorial localisation is even rarer. We present a 45-year-old woman with hydatid disease located in premedullary location compressing the brain stem, an exceedingly rare location for cerebral echinococcosis. Relevant literature regarding typical properties of cerebral disease was reviewed.

  3. The importance of location for a business

    OpenAIRE

    Zinchenko, A. V.; Зинченко, А. В.

    2012-01-01

    The article is investigated the importance of location for a business. A great location can contribute to the success of a business. In this article we are going to notice key points of choosing the best place for your business. For instance, some of the things that should be considered include the location and its overall desirability, as well as the accessibility from highways and mass transit for employees and customers, significance of company’s image and role of relationships with compet...

  4. Location-based Marketing: the academic framework

    OpenAIRE

    Buczkowski, Aleksander

    2012-01-01

    Dissertation submitted in partial fulfillment of the requirements for the Degree of Master of Science in Geospatial Technologies. Over the last several years one could observe revolution in location-based technologies and geospatial information. Location awareness of mobile devices resulted in development of Location-Based Services (LBS) that are realization of that revolution in the most personal and contextual way. The ability to reach consumers in the highly targeted manner ...

  5. Parnassiana nova : LV. Alancastria Cerisyi Godard

    NARCIS (Netherlands)

    Eisner, C.

    1979-01-01

    Als ich 1974 in Parn. Nov. 49 (Erster Teil) das Genus Alancastria Bryk behandelte, waren mir zwei wichtige Publicationen nicht bekannt: T. B. Larsen's "Two species of Alancastria Bryk in Libanon" und Dr. G. Bernardi's Beschreibung von A. deyrollei subsp. eisneri, die meine Zweifel über die Einreihun

  6. Information er sølv ..

    DEFF Research Database (Denmark)

    Brier, Søren

    del 2: Træk af moderne naturvidenskabsteori med særlig vægt på forholdet mellem Popper og Kuhn......del 2: Træk af moderne naturvidenskabsteori med særlig vægt på forholdet mellem Popper og Kuhn...

  7. SWIFT-nanoLV Avionics Platform Project

    Data.gov (United States)

    National Aeronautics and Space Administration — With the increased demand for and utility of nano- and micro-satellites, the demand for responsive, low-cost access to space has also increased. To meet this demand,...

  8. Accessibility, activity participation and location of activities

    DEFF Research Database (Denmark)

    Næss, Petter

    2006-01-01

    By investigating relationships between residential location and the availability of facilities, location of activities, trip distances, activity participation and trip frequencies, this paper seeks to contribute to a more detailed and nuanced understanding of the relationships between residential...... location and the amount of daily-life travel in an urban region. The empirical data are from a comprehensive study of residential location and travel in Copenhagen Metropolitan Area. Differences between inner- and outer-area residents in activity frequencies and trip frequencies are modest and partly...

  9. Semantic Location Extraction from Crowdsourced Data

    Science.gov (United States)

    Koswatte, S.; Mcdougall, K.; Liu, X.

    2016-06-01

    Crowdsourced Data (CSD) has recently received increased attention in many application areas including disaster management. Convenience of production and use, data currency and abundancy are some of the key reasons for attracting this high interest. Conversely, quality issues like incompleteness, credibility and relevancy prevent the direct use of such data in important applications like disaster management. Moreover, location information availability of CSD is problematic as it remains very low in many crowd sourced platforms such as Twitter. Also, this recorded location is mostly related to the mobile device or user location and often does not represent the event location. In CSD, event location is discussed descriptively in the comments in addition to the recorded location (which is generated by means of mobile device's GPS or mobile communication network). This study attempts to semantically extract the CSD location information with the help of an ontological Gazetteer and other available resources. 2011 Queensland flood tweets and Ushahidi Crowd Map data were semantically analysed to extract the location information with the support of Queensland Gazetteer which is converted to an ontological gazetteer and a global gazetteer. Some preliminary results show that the use of ontologies and semantics can improve the accuracy of place name identification of CSD and the process of location information extraction.

  10. A New Text Location Approach Based Wavelet

    Institute of Scientific and Technical Information of China (English)

    Weihua Li; Zhen Fang; Shuozhong Wang

    2002-01-01

    With the advancement of content-based retrieval technology, the importance of semantics for text information contained in images attracts many researchers. An algorithm which will automatically locate the textual regions in the input image will facilitate the retrieving task, and the optical character recognizer can then be applied to only those regions of the image which contain text. In this paper a new text location method based wavelet is described, which can be used to locate textual regions from complex image and video frame. Experimental results show that the textual regions in image can be located effectively and quickly.

  11. Overdenture locator attachments for atrophic mandible.

    Science.gov (United States)

    Mahajan, Neerja; Thakkur, Rahul K

    2013-10-01

    Implant-supported overdentures provide a good opportunity for dentists to improve oral health and quality-of-life of patients. Atrophic mandible poses a significant challenge to successful oral rehabilitation with dental implants. In this article, the fabrication of lower overdenture by two narrow platform implants is described with dual retentive, resilient, self-locating locator attachment system. The locator attachment system has the lowest profile in comparison with the ball and bar attachments and is versatile up to 40° of divergence between two implants. By using locators as attachments, we can meet functional, economic and social expectation of patients with ease and satisfaction.

  12. Overdenture locator attachments for atrophic mandible

    Directory of Open Access Journals (Sweden)

    Neerja Mahajan

    2013-01-01

    Full Text Available Implant-supported overdentures provide a good opportunity for dentists to improve oral health and quality-of-life of patients. Atrophic mandible poses a significant challenge to successful oral rehabilitation with dental implants. In this article, the fabrication of lower overdenture by two narrow platform implants is described with dual retentive, resilient, self-locating locator attachment system. The locator attachment system has the lowest profile in comparison with the ball and bar attachments and is versatile up to 40΀ of divergence between two implants. By using locators as attachments, we can meet functional, economic and social expectation of patients with ease and satisfaction.

  13. A New Text Location Approach Based Wavelet

    Institute of Scientific and Technical Information of China (English)

    Weihua Li; Zhen Fang; Shuozhong Wang

    2002-01-01

    With the advancement of content-based retrieval technology, the importance of semantics for text information contained in images attracts many researchers. An algorithm which will automatically locate the textual regions in the input image will facilitate the retrieving task, and the optical character recognizer can then be applied to only those regions of the image which contain text. In this paper a new text location method is described, which can be used to locate textual regions from complex image and video frame. Experimental results show that the textual regions in image can be located effectively and quickly.

  14. An Empirical Analysis of Humanitarian Warehouse Locations

    Directory of Open Access Journals (Sweden)

    Sander de Leeuw

    2016-06-01

    Full Text Available The purpose of this paper is to empirically verify characteristics of current warehouse locations of humanitarian organizations (based on public information and to relate those to the model developed by Richardson, de Leeuw and Dullaert (2016. This paper is based on desk research. Public data such as (annual reports and databases are used to determine the features of the location in empirical terms. We find that a significant proportion of our sample co-locates their products at UNHRD premises. This suggests that organizations prefer to cluster their warehouse activities, particularly when there is no fee involved for using the warehouse (as is the case in the UNHRD network. The geographic map of the current warehouses, together with the quantified location factors, provides an overview of the current warehouse locations. We found that the characteristics of the current warehouse locations are aligned with literature on location selection factors. Current location can be characterized by infrastructure characteristics (in particular closeness to airport and safety concerns and by the low occurrence of disasters. Other factors that were considered by us but were not supported by empirical evidence were labor quality and availability as well as the political environment. In our study we were only able to use a limited sample of warehouses. We also focused our research on countries where two or more organizations have their warehouses located. We did not account for warehouse sizes or the kinds of products stored in our analysis.

  15. Lead resistant bacteria: lead resistance mechanisms, their applications in lead bioremediation and biomonitoring.

    Science.gov (United States)

    Naik, Milind Mohan; Dubey, Santosh Kumar

    2013-12-01

    Lead (Pb) is non-bioessential, persistent and hazardous heavy metal pollutant of environmental concern. Bioremediation has become a potential alternative to the existing technologies for the removal and/or recovery of toxic lead from waste waters before releasing it into natural water bodies for environmental safety. To our best knowledge, this is a first review presenting different mechanisms employed by lead resistant bacteria to resist high levels of lead and their applications in cost effective and eco-friendly ways of lead bioremediation and biomonitoring. Various lead resistant mechanisms employed by lead resistant bacteria includes efflux mechanism, extracellular sequestration, biosorption, precipitation, alteration in cell morphology, enhanced siderophore production and intracellular lead bioaccumulation.

  16. An Undersea Mining Microseism Source Location Algorithm Considering Wave Velocity Probability Distribution

    OpenAIRE

    2014-01-01

    The traditional mine microseism locating methods are mainly based on the assumption that the wave velocity is uniform through the space, which leads to some errors for the assumption goes against the laws of nature. In this paper, the wave velocity is regarded as a random variable, and the probability distribution information of the wave velocity is fused into the traditional locating method. This paper puts forwards the microseism source location method for the undersea mining on condition o...

  17. Lead levels of Culex mosquito larvae inhabiting lead utilizing factory

    Institute of Scientific and Technical Information of China (English)

    Kitvatanachai S; Apiwathnasorn C; Leemingsawat S; Wongwit W; Overgaard HJ

    2011-01-01

    Objective: To determine lead level primarily in Culex quinquefasciatus (Cx. quinquefasciatus), and Culex gelidus (Cx. gelidus) larvae inhabiting lead consuming factories, and to putatively estimate eco-toxicological impact of effluents from the firms. Methods: Third instars larvae were sampled by standard dipping method and lead concentrations in the larvae and their respective surrounding factory aquatic environments were determined through standard atomic absorption spectrophotometry (AAS). Results: Cx. quinquefasciatus was the most abundant species followed by Cx. gelidus. The levels of lead were higher in the Cx. quinquefasciatus (1.08-47.47 μg/g), than in the wastewaters surface (0.01-0.78 μg/mL) from the factories or closer areas around factories. Other species were not reaching the criteria for lead determination. Conclusions: The Cx.quinquefasciatus larvae can bio-accumulate the metal and can potentially serve as a biomarker of lead contamination, to complemente conventional techniques.

  18. Prevalence of lead disease among secondary lead smelter workers and biological indicators of lead exposure

    Energy Technology Data Exchange (ETDEWEB)

    Lilis, R. (City Univ. of New York); Fischbein, A.; Eisinger, J.

    1977-10-01

    The report concerns itself primarily with the assessment of medical and biochemical effects of chronic lead exposure and comparing the usefulness of various biological screening parameters. In addition it appraises the effects of chelation therapy to control blood lead levels in lead workers, which have recently attracted critical attention. It is of considerable importance to ascertain whether such a therapeutic approach may, under some circumstances, in fact contribute to the deleterious effects of undue lead exposure.

  19. Private Information Retrieval Techniques for Enabling Location Privacy in Location-Based Services

    Science.gov (United States)

    Khoshgozaran, Ali; Shahabi, Cyrus

    The ubiquity of smartphones and other location-aware hand-held devices has resulted in a dramatic increase in popularity of location-based services (LBS) tailored to user locations. The comfort of LBS comes with a privacy cost. Various distressing privacy violations caused by sharing sensitive location information with potentially malicious services have highlighted the importance of location privacy research aiming to protect user privacy while interacting with LBS.

  20. Chronic lead poisoning in horses

    Energy Technology Data Exchange (ETDEWEB)

    Knight, H.D.; Burau, R.G.

    1973-05-01

    Chronic lead poisoning in horses was manifested as anorexia, loss of body weight, muscular weakness, anemia, laryngeal hemiplegia, and, terminally, inhalation pneumonia. Some deaths were sudden and unexplained. The lead content in liver specimens from 10 horses was greater than that considered indicative of lead intoxication; however, the lead content of blood was equivocal. The most conclusive laboratory finding was increased urine lead concentration after chelation therapy. The concentration of lead in a sample of vegetation considered to be representative of what a horse would eat if he was grazing in the area sampled was 325 ppM (oven-dry basis). It was determined that a 450-kg horse grazing grass of this lead content would consume 2.9 Gm of lead daily (6.4 mg/kg of body weight), an amount considered toxic for horses. Leaching lowered the calcium content of the forage but failed to reduce the lead concentration of the plants significantly, thus opening the possibility that winter rains might have influenced the onset of poisoning. Airborne fallout from a nearby lead smelter was proposed as the primary mode of pasture contamination.