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  1. Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction

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    R.M. Saraiva; Kanashiro-Takeuchi,R.M.; E.L. Antonio; Campos, O; P.J.F. Tucci; Moisés,V.A.

    2007-01-01

    The severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals with high LV end-diastolic pressure as a marker of LV dysfunction soon after MI. Direct measurements of LV end-diastolic pressure were made and DE was performed simultaneously 1 week after surgica...

  2. Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction.

    Science.gov (United States)

    Saraiva, R M; Kanashiro-Takeuchi, R M; Antonio, E L; Campos, O; P J F, Tucci; Moisés, V A

    2007-11-01

    The severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals with high LV end-diastolic pressure as a marker of LV dysfunction soon after MI. Direct measurements of LV end-diastolic pressure were made and DE was performed simultaneously 1 week after surgically induced MI (N = 16) or sham-operation (N = 17) in female Wistar rats (200 to 250 g). The ratio of peak early (E) to late (A) diastolic LV filling velocities and the ratio of E velocity to peak early (Em) diastolic myocardial velocity were the best predictors of high LV end-diastolic pressure (>12 mmHg) soon after MI. Cut-off values of 1.77 for the E/A ratio (P = 0.001) identified rats with elevated LV end-diastolic pressure with 90% sensitivity and 80% specificity. Cut-off values of 20.4 for the E/Em ratio (P = 0.0001) identified rats with elevated LV end-diastolic pressure with 81.8% sensitivity and 80% specificity. Moreover, E/A and E/Em ratios were the only echocardiographic parameters independently associated with LV end-diastolic pressure in multiple linear regression analysis. Therefore, DE identifies rats with high LV end-diastolic pressure soon after MI. These findings have implications for using serial DE in animal selection and in the assessment of their response to experimental therapies.

  3. Left ventricle expands maximally preceding end-diastole. Radionuclide ventriculography study

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    Horinouchi, Osamu [Kagoshima Univ. (Japan). Faculty of Medicine

    2002-05-01

    It has been considered that left ventricle (LV) expands maximally at the end-diastole. However, is it exactly coincident with this point? This study was aimed to determine whether the maximal expansion of LV coincides with the peak of R wave on electrocardiogram. Thirty-three angina pectoris patients with normal LV motion were examined using radionuclide ventriculography. Data were obtained from every 30 ms backward frame from the peak of R wave. All patients showed the time of maximal expansion preceded the peak of R wave. The intervals from the peak of R wave and the onset of P wave to maximal expansion of LV was 105{+-}29 ms and 88{+-}25 ms, respectively. This period corresponds to the timing of maximal excurtion of mitral valve by atrial contraction, and the centripetal motion of LV without losing its volume before end-diastole may be interpreted on account of the movement of mitral valve toward closure. These findings suggest that LV expands maximally between P and R wave after atrial contraction, preceding the peak of R wave thought conventionally as the end-diastole. (author)

  4. Improved Cardiac MRI Volume Measurements in Patients with Tetralogy of Fallot by Independent End-Systolic and End-Diastolic Phase Selection

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    Freling, Hendrik G.; Pieper, Petronella G.; Vermeulen, Karin M.; van Swieten, Jeroen M.; Sijens, Paul E.; van Veldhuisen, Dirk J.; Willems, Tineke P.

    2013-01-01

    Objectives: To investigate to what extent cardiac MRI derived measurements of right ventricular (RV) volumes using the left ventricular (LV) end-systolic and end-diastolic frame misrepresent RV end-systolic and end-diastolic volumes in patients with tetralogy of Fallot (ToF) and a right bundle

  5. Improved cardiac MRI volume measurements in patients with tetralogy of Fallot by independent end-systolic and end-diastolic phase selection.

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    Hendrik G Freling

    Full Text Available OBJECTIVES: To investigate to what extent cardiac MRI derived measurements of right ventricular (RV volumes using the left ventricular (LV end-systolic and end-diastolic frame misrepresent RV end-systolic and end-diastolic volumes in patients with tetralogy of Fallot (ToF and a right bundle branch block. METHODS: Sixty-five cardiac MRI scans of patients with ToF and a right bundle branch block, and 50 cardiac MRI scans of control subjects were analyzed. RV volumes and function using the end-systolic and end-diastolic frame of the RV were compared to using the end-systolic and end-diastolic frame of the LV. RESULTS: Timing of the RV end-systolic frame was delayed compared to the LV end-systolic frame in 94% of patients with ToF and in 50% of control subjects. RV end-systolic volume using the RV end-systolic instead of LV end-systolic frame was smaller in ToF (median -3.3 ml/m(2, interquartile range -1.9 to -5.6 ml/m(2; p<0.001 and close to unchanged in control subjects. Using the RV instead of LV end-systolic and end-diastolic frame hardly affected RV end-diastolic volumes in both groups and ejection fraction in control subjects (54±4%, both methods, while increasing ejection fraction from 45±7% to 48±7% for patients with ToF (p<0.001. QRS duration correlated positively with the changes in the RV end-systolic volume (p<0.001 and RV ejection fraction obtained in ToF patients when using the RV instead of the LV end-systolic and end-diastolic frame (p = 0.004. CONCLUSION: For clinical decision making in ToF patients RV volumes derived from cardiac MRI should be measured in the end-systolic frame of the RV instead of the LV.

  6. Spectral transfer function analysis of respiratory hemodynamic fluctuations predicts end-diastolic stiffness in preserved ejection fraction heart failure.

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    Abdellatif, Mahmoud; Leite, Sara; Alaa, Mohamed; Oliveira-Pinto, José; Tavares-Silva, Marta; Fontoura, Dulce; Falcão-Pires, Inês; Leite-Moreira, Adelino F; Lourenço, André P

    2016-01-01

    Preserved ejection fraction heart failure (HFpEF) diagnosis remains controversial, and invasive left ventricular (LV) hemodynamic evaluation and/or exercise testing is advocated by many. The stiffer HFpEF myocardium may show impaired stroke volume (SV) variation induced by fluctuating LV filling pressure during ventilation. Our aim was to investigate spectral transfer function (STF) gain from end-diastolic pressure (EDP) to indexed SV (SVi) in experimental HFpEF. Eighteen-week-old Wistar-Kyoto (WKY) and ZSF1 lean (ZSF1 Ln) and obese rats (ZSF1 Ob) randomly underwent LV open-chest (OC, n = 8 each group) or closed-chest hemodynamic evaluation (CC, n = 6 each group) under halogenate anesthesia and positive-pressure ventilation at constant inspiratory pressure. Beat-to-beat fluctuations in hemodynamic parameters during ventilation were assessed by STF. End-diastolic stiffness (βi) and end-systolic elastance (Eesi) for indexed volumes were obtained by inferior vena cava occlusion in OC (multibeat) or single-beat method estimates in CC. ZSF1 Ob showed higher EDP spectrum (P heart catheterization-derived EDP surrogates to noninvasively determined SV as screening/diagnostic tool to assess myocardial stiffness in HFpEF.

  7. Hypertensive heart disease versus hypertrophic cardiomyopathy: multi-parametric cardiovascular magnetic resonance discriminators when end-diastolic wall thickness ≥ 15 mm

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    Rodrigues, Jonathan C.L. [University Hospitals Bristol NHS Foundation Trust, NIHR Bristol Cardiovascular Biomedical Research Unit, Cardiac Magnetic Resonance Department, Bristol Heart Institute (United Kingdom); University of Bristol, School of Physiology, Pharmacology and Neuroscience, Faculty of Biomedical Sciences (United Kingdom); Rohan, Stephen [University of Bristol, Medical School, Faculty of Medicine and Dentistry (United Kingdom); Ghosh Dastidar, Amardeep; Harries, Iwan; Lawton, Christopher B. [University Hospitals Bristol NHS Foundation Trust, NIHR Bristol Cardiovascular Biomedical Research Unit, Cardiac Magnetic Resonance Department, Bristol Heart Institute (United Kingdom); Ratcliffe, Laura E.; Burchell, Amy E.; Nightingale, Angus K. [University Hospitals Bristol NHS Foundation Trust, CardioNomics Research Group, Clinical Research and Imaging Centre, Bristol Heart Institute (United Kingdom); Hart, Emma C.; Paton, Julian F.R. [University of Bristol, School of Physiology, Pharmacology and Neuroscience, Faculty of Biomedical Sciences (United Kingdom); University Hospitals Bristol NHS Foundation Trust, CardioNomics Research Group, Clinical Research and Imaging Centre, Bristol Heart Institute (United Kingdom); Hamilton, Mark C.K. [University Hospitals Bristol NHS Foundation Trust, Department of Radiology, Bristol Royal Infirmary (United Kingdom); Manghat, Nathan E. [University Hospitals Bristol NHS Foundation Trust, NIHR Bristol Cardiovascular Biomedical Research Unit, Cardiac Magnetic Resonance Department, Bristol Heart Institute (United Kingdom); University Hospitals Bristol NHS Foundation Trust, Department of Radiology, Bristol Royal Infirmary (United Kingdom)

    2017-03-15

    European guidelines state left ventricular (LV) end-diastolic wall thickness (EDWT) ≥15 mm suggests hypertrophic cardiomyopathy (HCM), but distinguishing from hypertensive heart disease (HHD) is challenging. We identify cardiovascular magnetic resonance (CMR) predictors of HHD over HCM when EDWT ≥15 mm. 2481 consecutive clinical CMRs between 2014 and 2015 were reviewed. 464 segments from 29 HCM subjects with EDWT ≥15 mm but without other cardiac abnormality, hypertension or renal impairment were analyzed. 432 segments from 27 HHD subjects with EDWT ≥15 mm but without concomitant cardiac pathology were analyzed. Magnitude and location of maximal EDWT, presence of late gadolinium enhancement (LGE), LV asymmetry (>1.5-fold opposing segment) and systolic anterior motion of the mitral valve (SAM) were measured. Multivariate logistic regression was performed. Significance was defined as p<0.05. HHD and HCM cohorts were age-/gender-matched. HHD had significantly increased indexed LV mass (110±27 g/m{sup 2} vs. 91±31 g/m{sup 2}, p=0.016) but no difference in site or magnitude of maximal EDWT. Mid-wall LGE was significantly more prevalent in HCM. Elevated indexed LVM, mid-wall LGE and absence of SAM were significant multivariate predictors of HHD, but LV asymmetry was not. Increased indexed LV mass, absence of mid-wall LGE and absence of SAM are better CMR discriminators of HHD from HCM than EDWT ≥15 mm. circle Hypertrophic cardiomyopathy (HCM) is often diagnosed with end-diastolic wall thickness ≥15 mm. (orig.)

  8. Automatic detection of end-diastole and end-systole from echocardiography images using manifold learning.

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    Gifani, Parisa; Behnam, Hamid; Shalbaf, Ahmad; Sani, Zahra Alizadeh

    2010-09-01

    The automatic detection of end-diastole and end-systole frames of echocardiography images is the first step for calculation of the ejection fraction, stroke volume and some other features related to heart motion abnormalities. In this paper, the manifold learning algorithm is applied on 2D echocardiography images to find out the relationship between the frames of one cycle of heart motion. By this approach the nonlinear embedded information in sequential images is represented in a two-dimensional manifold by the LLE algorithm and each image is depicted by a point on reconstructed manifold. There are three dense regions on the manifold which correspond to the three phases of cardiac cycle ('isovolumetric contraction', 'isovolumetric relaxation', 'reduced filling'), wherein there is no prominent change in ventricular volume. By the fact that the end-systolic and end-diastolic frames are in isovolumic phases of the cardiac cycle, the dense regions can be used to find these frames. By calculating the distance between consecutive points in the manifold, the isovolumic frames are mapped on the three minimums of the distance diagrams which were used to select the corresponding images. The minimum correlation between these images leads to detection of end-systole and end-diastole frames. The results on six healthy volunteers have been validated by an experienced echo cardiologist and depict the usefulness of the presented method.

  9. NONLINEAR DYNAMICS MODFLING OF MECHANICAL PERIODICITY OF END DIASTOLIC VOLUME OF LEFT VENTRICLE

    Institute of Scientific and Technical Information of China (English)

    许世雄; 毛晓春

    2001-01-01

    The cardiovascular system with a lumped parameter model is treated, in which the Starling model is used to simulate left ventricle and the four-element Burattini & Gnudi model is used in the description of arterial system. Moreover, the feedback action of arterial pressure on cardiac cycle is taken into account. The phenomenon of mechanical periodicity (MP) of end diastolic volume (EDV) of left ventricle is successfully simulated by solving a series of one-dimensional discrete nonlinear dynamical equations. The effects of cardiovascular parameters on MP is also discussed.

  10. Impact of mitral E/A ratio on the accuracy of different echocardiographic indices to estimate left ventricular end-diastolic pressure.

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    Poerner, Tudor C; Goebel, Björn; Kralev, Stefan; Kaden, Jens J; Süselbeck, Tim; Haase, Karl K; Borggrefe, Martin; Haghi, Dariusch

    2007-05-01

    The objective was to determine the influence of left ventricular (LV) inflow pattern on the accuracy of different echocardiographic indices for estimation of LV end-diastolic pressure (LVEDP). Echocardiography with color tissue Doppler imaging (TDI) and LVEDP measurements using fluid-filled catheters were performed in 176 consecutive patients on the same day. Mitral peak diastolic velocities (E, A) and the difference in duration between pulmonary venous retrograde velocity and mitral A-velocity (PV(R)-A) were recorded by pulsed Doppler. Propagation velocity of the early mitral inflow (V(P)) was assessed using color M-mode. Early diastolic longitudinal (E'(lat)) and radial (E'(radial)) velocities of mitral annulus were measured by TDI. Area under ROC curve (AUC) for prediction of elevated LVEDP (> or =15 mm Hg) was computed for each parameter. For E/A > or =1 (98 patients, 46 with elevated LVEDP), the AUC values were: PV(R)-A: 0.914; E/E'(lat): 0.780; E/E'(radial): 0.729; E/V(P): 0.712 (p PV(R)-A reached statistical significance (AUC = 0.893, p PV(R)-A enabled the most accurate noninvasive estimation of LVEDP irrespective of LV filling profile and combined indices E/V(P), E/E'(lat) and E/E'(radial) represent more feasible alternatives for patients with mitral E/A-1.

  11. Perinatal outcome of growth restricted fetus with absent end diastolic umbilical blood flow: Case report

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    Tasić Marija

    2010-01-01

    Full Text Available Introduction. Absent or reversed end-diastolic blood flow in the umbilical artery is usually associated with poor perinatal outcome and high perinatal mortality rate. Case report. We present the case of a pregnant woman with absent end-diastolic blood flow in the umbilical artery in the 27th week of pregnancy with initial restriction of fetal growth. All though it was more and more obvious that the fetal growth was hindered, the Doppler, cardiotocographic and biophysical parameters did not get any worse as the pregnancy developed. The full fetal maturation was reached after the intense monitoring of the fetal condition and the pregnancy was terminated in the 37lh week by elective Cesarean section. Conclusion. The basic purpose of prenatal fetal monitoring in the situation of hindered fetal growth with chronic hypoxia is to predict the phase of decompensation and to terminate pregnancy before it is developed. The major problem is in great individual variations at the moment of development of decompensation phase, so the major obstetric aim in the monitoring of the fetus hindered in growth is to determine the optimal time and way of delivery.

  12. Hypertensive heart disease versus hypertrophic cardiomyopathy: multi-parametric cardiovascular magnetic resonance discriminators when end-diastolic wall thickness ≥ 15 mm.

    Science.gov (United States)

    Rodrigues, Jonathan C L; Rohan, Stephen; Ghosh Dastidar, Amardeep; Harries, Iwan; Lawton, Christopher B; Ratcliffe, Laura E; Burchell, Amy E; Hart, Emma C; Hamilton, Mark C K; Paton, Julian F R; Nightingale, Angus K; Manghat, Nathan E

    2017-03-01

    European guidelines state left ventricular (LV) end-diastolic wall thickness (EDWT) ≥15mm suggests hypertrophic cardiomyopathy (HCM), but distinguishing from hypertensive heart disease (HHD) is challenging. We identify cardiovascular magnetic resonance (CMR) predictors of HHD over HCM when EDWT ≥15mm. 2481 consecutive clinical CMRs between 2014 and 2015 were reviewed. 464 segments from 29 HCM subjects with EDWT ≥15mm but without other cardiac abnormality, hypertension or renal impairment were analyzed. 432 segments from 27 HHD subjects with EDWT ≥15mm but without concomitant cardiac pathology were analyzed. Magnitude and location of maximal EDWT, presence of late gadolinium enhancement (LGE), LV asymmetry (>1.5-fold opposing segment) and systolic anterior motion of the mitral valve (SAM) were measured. Multivariate logistic regression was performed. Significance was defined as pheart disease (HHD) can be difficult to distinguish from HCM. • Retrospective case-control study showed that location and magnitude of EDWT are poor discriminators. • Increased left ventricular mass and midwall fibrosis are independent predictors of HHD. • Cardiovascular magnetic resonance parameters facilitate a better discrimination between HHD and HCM.

  13. Left ventricular ejection fraction and left ventricular end-diastolic volume in patients with diastolic dysfunction.

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    Jovin, Ion S; Ebisu, Keita; Liu, Yi-Hwa; Finta, Laurie A; Oprea, Adriana D; Brandt, Cynthia A; Dziura, James; Wackers, Frans J

    2013-01-01

    Diastolic dysfunction can be diagnosed on equilibrium radionuclide angiocardiography (ERNA) by a low peak filling rate (PFR) in the setting of a normal left ventricular ejection fraction (LVEF). The authors evaluated the relationship between diastolic dysfunction, LVEF, and end-diastolic volume (EDV). A total of 408 predominantly asymptomatic patients with an LVEF ≥50% by ERNA were studied. LVEF of patients with a low PFR was compared with the LVEF of patients with a normal PFR. Correlation analyses to evaluate the association between PFR and EDV were also performed. The LVEF of patients with a low PFR was lower than the LVEF of patients with normal PFR (59±7 vs 63%±7%; PPFR (r=-0.04; P=.32). The results did not change when the EDV indices were used. In patients who had repeat scans, there was no correlation between the change in EDV and the change in PFR (r=0.16; P=.2). In asymptomatic patients undergoing ERNA who have normal systolic function, a low PFR can be associated with a lower LVEF, but it is not associated with changes in EDV. This suggests that diastolic dysfunction is associated with mild systolic dysfunction.

  14. Effect of transcatheter aortic valve implantation on intraoperative left ventricular end-diastolic pressure.

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    Toyota, Kosaku; Ota, Takashi; Nagamine, Katsutoshi; Koide, Yasuhiro; Nomura, Takeshi; Yamanaka, Futoshi; Shishido, Koki; Tanaka, Masashi; Saito, Shigeru

    2016-12-01

    Transcatheter aortic valve implantation (TAVI) for patients with aortic stenosis is a less invasive alternative to surgical aortic valve replacement. Despite this, careful anesthetic management, especially strict control of blood pressure and fluid management, is necessary. During TAVI, normalization of left ventricular afterload due to aortic balloon valvuloplasty and prosthetic valve deployment is expected to result in rapid improvement of systolic function and consequent improvement in diastolic function. However, the early effect of TAVI on left ventricular diastolic function is less clear. We hypothesized that TAVI induces a rapid decrease in left ventricular end-diastolic pressure (LVEDP) after valve deployment. This retrospective observational study included 71 patients who had undergone TAVI using the transfemoral approach with a balloon-expandable valve under general anesthesia. Intraoperative LVEDP was measured using an intracardiac catheter. The severity of residual aortic regurgitation (AR) was assessed using the Sellers criteria. The mean (SD) LVEDP was 17.8 (5.3) mmHg just before TAVI and increased significantly to 27.3 (8.2) mmHg immediately after prosthetic valve deployment (p < 0.0001). The change in LVEDP was 8.7 (8.6) mmHg in patients with low residual AR (Sellers ≤1) and 11.0 (7.1) mmHg in those with high residual AR (Sellers ≥2); however, this difference was not significant. No correlation was found between the LVEDP change and intraoperative fluid balance. In conclusion, LVEDP increased significantly in the early period after valve deployment during TAVI, regardless of residual AR severity. It was suggested that the tolerability of fluid load could be reduced at that time.

  15. Echocardiographic dimensions and function in adults with primary growth hormone resistance (Laron syndrome).

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    Feinberg, M S; Scheinowitz, M; Laron, Z

    2000-01-15

    Patients with primary growth hormone (GH) resistance-Laron Syndrome (LS)-have no GH signal transmission, and thus, no generation of circulating insulin-like growth factor-I (IGF-I), and should serve as a unique model to explore the controversies concerning the longterm effect of GH/IGF-I deficiency on cardiac dimension and function. We assessed 8 patients with LS (4 men, 4 women) with a mean (+/- SD) age of 38+/-7 years (range 22 to 45), and 8 aged-matched controls (4 men, 4 women) with a mean age of 38+/-9 years (range 18 to 47) by echocardiography at rest, following exercise, and during dobutamine administration. Left ventricular (LV) septum, posterior wall, and end-diastolic diameter were significantly reduced in untreated patients with LS compared with the control group (p<0.05 for all). Systolic Doppler-derived parameters, including LV stroke volume, stroke index, cardiac output, and cardiac index, were significantly lower (p<0.05 for all) than in the control subjects, whereas LV diastolic Doppler parameters, including mitral valve waves E, A, E/A ratio, and E deceleration time, were similar in both groups. LV ejection fraction at rest as well as the stress-induced increment of the LV ejection fraction were similar in both groups. Our results show that untreated patients with long-term IGF-I deficiency have reduced cardiac dimensions and output but normal LV ejection fraction at rest and LV contractile reserve following stress.

  16. Carotid Artery End-Diastolic Velocity and Future Cerebro-Cardiovascular Events in Asymptomatic High Risk Patients.

    Science.gov (United States)

    Chung, Hyemoon; Jung, Young Hak; Kim, Ki-Hyun; Kim, Jong-Youn; Min, Pil-Ki; Yoon, Young Won; Lee, Byoung Kwon; Hong, Bum-Kee; Rim, Se-Joong; Kwon, Hyuck Moon; Choi, Eui-Young

    2016-01-01

    Prognostic value of additional carotid Doppler evaluations to carotid intima-media thickness (IMT) and plaque has not been completely evaluated. A total of 1119 patients with risk factors for, but without, overt coronary artery disease (CAD), who underwent both carotid ultrasound and Doppler examination were included in the present study. Parameters of interest included peak systolic and end-diastolic velocities, resistive indices of the carotid arteries, IMT, and plaque measurements. The primary end-point was all-cause cerebro-cardiovascular events (CVEs) including acute myocardial infarction, coronary revascularization therapy, heart failure admission, stroke, and cardiovascular death. Model 1 covariates comprised age and sex; Model 2 also included hypertension, diabetes and smoking; Model 3 also had use of aspirin and statin; and Model 4 also included IMT and plaque. The mean follow-up duration was 1386±461 days and the mean age of the study population was 60±12 years. Amongst 1119 participants, 43% were women, 57% had a history of hypertension, and 23% had diabetes. During follow-up, 6.6% of patients experienced CVEs. Among carotid Doppler parameters, average common carotid artery end-diastolic velocity was the independent predictor for future CVEs after adjustments for all models variables (HR 0.95 per cm/s, 95% confident interval 0.91-0.99, p=0.034 in Model 4) and significantly increased the predictive value of Model 4 (global χ(2)=59.0 vs. 62.8, p=0.029). Carotid Doppler measurements in addition to IMT and plaque evaluation are independently associated with future CVEs in asymptomatic patients at risk for CAD.

  17. A Model for Measured Traveling Waves at End-Diastole in Human Heart Wall by Ultrasonic Imaging Method

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    Bekki, Naoaki; Shintani, Seine A.; Ishiwata, Shin'ichi; Kanai, Hiroshi

    2016-04-01

    We observe traveling waves, measured by the ultrasonic noninvasive imaging method, in a longitudinal beam direction from the apex to the base side on the interventricular septum (IVS) during the period from the end-diastole to the beginning of systole for a healthy human heart wall. We present a possible phenomenological model to explain part of one-dimensional cardiac behaviors for the observed traveling waves around the time of R-wave of echocardiography (ECG) in the human heart. Although the observed two-dimensional patterns of traveling waves are extremely complex and no one knows yet the exact solutions for the traveling homoclinic plane wave in the one-dimensional complex Ginzburg-Landau equation (CGLE), we numerically find that part of the one-dimensional homoclinic dynamics of the phase and amplitude patterns in the observed traveling waves is similar to that of the numerical homoclinic plane-wave solutions in the CGLE with periodic boundary condition in a certain parameter space. It is suggested that part of the cardiac dynamics of the traveling waves on the IVS can be qualitatively described by the CGLE model as a paradigm for understanding biophysical nonlinear phenomena.

  18. Comparison of values in critically ill patients for global end-diastolic volume and extravascular lung water measured by transcardiopulmonary thermodilution : A metaanalysis of the literature

    NARCIS (Netherlands)

    Eichhorn, V.; Goepfert, M. S.; Eulenburg, C.; Malbrain, M. L. N. G.; Reuter, D. A.

    2012-01-01

    Introduction: Hemodynamic parameters such as the global end-diastolic volume index (GEDVI) and extravascular lung water index (EVLWI), derived by transpulmonary thermodilution, have gained increasing interest for guiding fluid therapy in critically ill patients. The proposed normal values (680-800 m

  19. Doppler Tissue Imaging: A Non-Invasive Technique for Estimation of Left Ventricular End Diastolic Pressure in Severe Mitral Regurgitation

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    Mojtaba Salarifar

    2010-08-01

    Full Text Available Background: Conventional Doppler measurements, including mitral inflow and pulmonary venous flow, are used to estimate left ventricular end diastolic pressure (LVEDP. However, these parameters have limitations in predicting LVEDP among patients with mitral regurgitation. This study sought to establish whether the correlation between measurements derived from tissue Doppler echocardiography and LVEDP remains valid in the setting of severe mitral regurgitation.Methods: Thirty patients (mean age: 57.37 ± 13.29 years with severe mitral regurgitation and a mean left ventricular ejection fraction (EF of 46.0 ± 14.95 were enrolled; 16 (53.4% patients were defined to have EF < 50% and 14 (46.6% patients had EF ≥ 50%. Doppler signals from the mitral inflow, pulmonary venous flow, and Doppler tissue imaging indices were obtained, and LVEDP was measured invasively through cardiac catheterization.Results: The majority of the standard Doppler and Doppler tissue imaging indices were not significantly correlated with LVEDP in the univariate analysis. In the multiple linear regression, however, early (E transmitral velocity to annular E' (E/E' ratio (ß = 1.09, p value < 0.01, E wave velocity to propagation velocity (E/Vp ratio (ß = 7.87, p value < 0.01, and isovolumic relaxation time (ß = 0.21, p value = 0.01 were shown as independent predictors of LVEDP (R2 = 91.7%.Conclusion: The ratio of E/Vp and E/E' ratio and also the isovolumic relaxation time could be applied properly to estimate LVEDP in mitral regurgitation patients even in the setting of severe mitral regurgitation.

  20. Poor agreement between pulmonary capillary wedge pressure and left ventricular end-diastolic pressure in a veteran population.

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    Abbas Bitar

    Full Text Available BACKGROUND: Accurate determination of left ventricular filling pressure is essential for differentiation of pre-capillary pulmonary hypertension (PH from pulmonary venous hypertension (PVH. Previous data suggest only a poor correlation between left ventricular end-diastolic pressure (LVEDP and its commonly used surrogate, the pulmonary capillary wedge pressure (PCWP. However, no data exist on the diagnostic accuracy of PCWP in veterans. Furthermore, the effects of age and comorbidities on the PCWP-LVEDP relationship remain unknown. METHODS: We investigated the PCWP-LVEDP relationship in 101 patients undergoing simultaneous right and left heart catherization at a large VA hospital. PCWP performance was evaluated using correlation and Bland-Altman analyses. Area under Receiver Operating Characteristics curves (AUROC for PCWP were determined. RESULTS: PCWP-LVEDP correlation was moderate (r = 0.57. PCWP-LVEDP calibration was poor (Bland-Altman limits of agreement -17.2 to 11.4 mmHg; mean bias -2.87 mmHg. 59 patients (58.4% had pulmonary hypertension; 15 (25.4% of those met pre-capillary PH criteria based on PCWP. However, if LVEDP was used instead of PCWP, 7/15 patients (46.6% met criteria for PVH rather than pre-capillary PH. When restricting analysis to patients with a mean pulmonary artery pressure of ≥25 mmHg and pulmonary vascular resistance of >3 Wood units (n = 22, 10 patients (45.4% were classified as pre-capillary PH based on PCWP ≤15 mmHg. However, if LVEDP was used, 4/10 patients (40% were reclassified as PVH. Among patients with any type of pulmonary hypertension, PCWP discriminated moderately between high and normal LVEDP (AUROC, 0.81; 95%CI 0.69-0.94. PCWP-LVEDP correlation was particularly poor in patients with COPD or obesity. CONCLUSION: Reliance on PCWP rather than LVEDP results in misclassification of veterans as having pre-capillary PH rather than PVH in almost 50% of cases. This is clinically relevant, as

  1. Novel approach for automatic segmentation of LV endocardium via SPCNN

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    Ma, Yurun; Wang, Deyuan; Ma, Yide; Lei, Ruoming; Wang, Kemin

    2017-02-01

    Automatic segmentation of Left Ventricle (LV) is an essential task in the field of computer-aided analysis of cardiac function. In this paper, a simplified pulse coupled neural network (SPCNN) based approach is proposed to segment LV endocardium automatically. Different from the traditional image-driven methods, the SPCNN based approach is independent of the image gray distribution models, which makes it more stable. Firstly, the temporal and spatial characteristics of the cardiac magnetic resonance image are used to extract a region of interest and to locate LV cavity. Then, SPCNN model is iteratively applied with an increasing parameter to segment an optimal cavity. Finally, the endocardium is delineated via several post-processing operations. Quantitative evaluation is performed on the public database provided by MICCAI 2009. Over all studies, all slices, and two phases (end-diastole and end-systole), the average percentage of good contours is 91.02%, the average perpendicular distance is 2.24 mm and the overlapping dice metric is 0.86.These results indicate that the proposed approach possesses high precision and good competitiveness.

  2. Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of heart failure treatments.

    Science.gov (United States)

    Genet, Martin; Lee, Lik Chuan; Nguyen, Rebecca; Haraldsson, Henrik; Acevedo-Bolton, Gabriel; Zhang, Zhihong; Ge, Liang; Ordovas, Karen; Kozerke, Sebastian; Guccione, Julius M

    2014-07-15

    Ventricular wall stress is believed to be responsible for many physical mechanisms taking place in the human heart, including ventricular remodeling, which is frequently associated with heart failure. Therefore, normalization of ventricular wall stress is the cornerstone of many existing and new treatments for heart failure. In this paper, we sought to construct reference maps of normal ventricular wall stress in humans that could be used as a target for in silico optimization studies of existing and potential new treatments for heart failure. To do so, we constructed personalized computational models of the left ventricles of five normal human subjects using magnetic resonance images and the finite-element method. These models were calibrated using left ventricular volume data extracted from magnetic resonance imaging (MRI) and validated through comparison with strain measurements from tagged MRI (950 ± 170 strain comparisons/subject). The calibrated passive material parameter values were C0 = 0.115 ± 0.008 kPa and B0 = 14.4 ± 3.18; the active material parameter value was Tmax = 143 ± 11.1 kPa. These values could serve as a reference for future construction of normal human left ventricular computational models. The differences between the predicted and the measured circumferential and longitudinal strains in each subject were 3.4 ± 6.3 and 0.5 ± 5.9%, respectively. The predicted end-diastolic and end-systolic myofiber stress fields for the five subjects were 2.21 ± 0.58 and 16.54 ± 4.73 kPa, respectively. Thus these stresses could serve as targets for in silico design of heart failure treatments.

  3. Normalisation of a severely abnormal ductus venosus Doppler flow velocity waveform in a growth-retarded fetus with absent end-diastolic flow in the umbilical artery and congenital anomalies.

    Science.gov (United States)

    Müller, T; Rehn, M; Girschick, G; Kristen, P; Dietl, J

    2001-01-01

    Doppler recordings of fetal venous blood flow seem to be superior to arterial velocimetry and CTG concerning the prediction of fetal outcome and optimal time of delivery in pregnancies with fetal growth retardation and AREDV. An improvement of arterial Doppler flow velocities has been described. We report the reappearance of a normal end-diastolic flow velocity in a ductus venosus temporarily showing reversed end-diastolic flow in a growth-retarded fetus with congenital anomalies. This normalization was accompanied by an improvement of the CTG, a loss of umbilical vein pulsations, a reappearance of umbilical diastolic flow and a progressive return of cerebral and venous blood flow into the 'normal' range. Improvement of fetal condition may be the explanation for our observation.

  4. Goal-directed fluid therapy: stroke volume optimisation and cardiac dimensions in supine healthy humans

    DEFF Research Database (Denmark)

    Jans, O.; Tollund, C.; Bundgaard-Nielsen, M.

    2008-01-01

    by thoracic electrical admittance, central venous oxygenation and pressure, and arterial plasma atrial natriuretic peptide. Also, muscle and brain oxygenation were assessed by near infrared spectroscopy (n=7). RESULTS: The HUT reduced the mentioned indices of CBV, the end-diastolic dimensions of the heart...... to head-up (HUT) and head-down tilt (HDT). METHODS: Twelve healthy volunteers underwent graded tilt from 20 degrees HDT to 30 degrees HUT. The end-diastolic dimensions of the heart were assessed by transthoracic echocardiography with independent evaluation of SV by Modelflow. The CBV was monitored...

  5. Left-sided cardiac chamber evaluation using single-phase mid-diastolic coronary computed tomography angiography: derivation of normal values and comparison with conventional end-diastolic and end-systolic phases

    Energy Technology Data Exchange (ETDEWEB)

    Walker, Jonathan R. [Technion-Israel Institute of Technology, Haifa (Israel); Abadi, Sobhi [Rambam Health Care Campus, Medical Imaging Department, Haifa (Israel); Solomonica, Amir [Rambam Health Care Campus, Cardiology Department, Haifa (Israel); Mutlak, Diab; Aronson, Doron; Agmon, Yoram; Lessick, Jonathan [Rambam Health Care Campus, Cardiology Department, Haifa (Israel); Technion-Israel Institute of Technology, Haifa (Israel)

    2016-10-15

    With increasing use of prospective scanning techniques for cardiac computed tomography (CT), meaningful evaluation of chamber volumes is no longer possible due to lack of normal values. We aimed to define normal values for mid-diastolic (MD) chamber volumes and to determine their significance in comparison to maximum volumes. Normal ranges at MD for left ventricular (LV) volume and mass and left atrial (LA) volume were determined from 101 normal controls. Thereafter, 109 consecutive CT scans, as well as 21 post-myocardial infarction patients, were analysed to determine the relationship between MD and maximum volumes. MD volumes correlated closely with maximal volumes (r = 0.99) for both LV and LA, and could estimate maximum volumes accurately. LV mass, measured at ED or MD, were very similar (r = 0.99). Abnormal MD volumes had excellent sensitivity and specificity to detect chamber enlargement based on maximal volumes (LV 86 %, 100 %, respectively; LA 100 %, 92 %, respectively). A single MD phase can identify patients with cardiomegaly or LV hypertrophy with a high degree of accuracy and MD volumes can give an accurate estimate of maximum LV and LA volumes. circle Traditionally, helical cardiac CT provided clinically important information from chamber volume analysis. (orig.)

  6. Assessment of Longitudinal Reproducibility of Mice LV Function Parameters at 11.7 T Derived from Self-Gated CINE MRI

    Science.gov (United States)

    Zuo, Zhi; Subgang, Anne; Abaei, Alireza; Rottbauer, Wolfgang; Stiller, Detlef; Ma, Genshan

    2017-01-01

    The objective of this work was the assessment of the reproducibility of self-gated cardiac MRI in mice at ultra-high-field strength. A group of adult mice (n = 5) was followed over 360 days with a standardized MR protocol including reproducible animal position and standardized planning of the scan planes. From the resulting CINE MRI data, global left ventricular (LV) function parameters including end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), and left ventricular mass (LVM) were quantified. The reproducibility of the self-gated technique as well as the intragroup variability and longitudinal changes of the investigated parameters was assessed. Self-gated cardiac MRI proved excellent reproducibility of the global LV function parameters, which was in the order of the intragroup variability. Longitudinal assessment did not reveal any significant variations for EDV, ESV, SV, and EF but an expected increase of the LVM with increasing age. In summary, self-gated MRI in combination with a standardized protocol for animal positioning and scan plane planning ensures reproducible assessment of global LV function parameters. PMID:28321415

  7. Assessment of Longitudinal Reproducibility of Mice LV Function Parameters at 11.7 T Derived from Self-Gated CINE MRI.

    Science.gov (United States)

    Zuo, Zhi; Subgang, Anne; Abaei, Alireza; Rottbauer, Wolfgang; Stiller, Detlef; Ma, Genshan; Rasche, Volker

    2017-01-01

    The objective of this work was the assessment of the reproducibility of self-gated cardiac MRI in mice at ultra-high-field strength. A group of adult mice (n = 5) was followed over 360 days with a standardized MR protocol including reproducible animal position and standardized planning of the scan planes. From the resulting CINE MRI data, global left ventricular (LV) function parameters including end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), and left ventricular mass (LVM) were quantified. The reproducibility of the self-gated technique as well as the intragroup variability and longitudinal changes of the investigated parameters was assessed. Self-gated cardiac MRI proved excellent reproducibility of the global LV function parameters, which was in the order of the intragroup variability. Longitudinal assessment did not reveal any significant variations for EDV, ESV, SV, and EF but an expected increase of the LVM with increasing age. In summary, self-gated MRI in combination with a standardized protocol for animal positioning and scan plane planning ensures reproducible assessment of global LV function parameters.

  8. Efficacy of an inactivated FeLV vaccine compared to a recombinant FeLV vaccine in minimum age cats following virulent FeLV challenge.

    Science.gov (United States)

    Stuke, Kristin; King, Vickie; Southwick, Kendra; Stoeva, Mira I; Thomas, Anne; Winkler, M Teresa C

    2014-05-07

    The aim of the study was to determine the efficacy of an inactivated feline leukemia virus (FeLV) vaccine (Versifel(®) FeLV, Zoetis.) compared to a recombinant FeLV vaccine (Purevax(®) FeLV, Merial Animal Health) in young cats, exposed under laboratory conditions to a highly virulent challenge model. The study was designed to be consistent with the general immunogenicity requirements of the European Pharmacopoeia 6.0 Monograph 01/2008:1321-Feline Leukaemia Vaccine (Inactivated) with the exception that commercial-strength vaccines were assessed. Fifty seronegative cats (8-9 weeks old) were vaccinated subcutaneously on two occasions, three weeks apart, with either placebo (treatment group T01), Versifel FeLV Vaccine (treatment group T02), or Purevax FeLV Vaccine (treatment group T03) according to the manufacturer's directions. Cats were challenged three weeks after the second vaccination with a virulent FeLV isolate (61E strain). Persistent FeLV antigenemia was determined from 3 to 15 weeks postchallenge. Bone marrow samples were tested for the presence of FeLV proviral DNA to determine FeLV latent infection. At week 15 after challenge with the virulent FeLV 61E strain, the Versifel FeLV Vaccine conferred 89.5% protection against FeLV persistent antigenemia and 94.7% protection against FeLV proviral DNA integration in bone marrow cells. In comparison, the Purevax FeLV Vaccine conferred 20% protection against FeLV persistent antigenemia and 35% protection against FeLV proviral DNA integration in bone marrow cells following challenge. The data from this study show that the Versifel FeLV Vaccine was efficacious in preventing both FeLV persistent p27 antigenemia and FeLV proviral DNA integration in bone marrow cells of cats challenged with this particular challenge model under laboratory conditions and provided better protection than Purevax FeLV in this experimental challenge model with highly virulent FeLV.

  9. Left ventricular dimensions and systolic function during spontaneous heart rate changes: an echocardiographic study.

    Science.gov (United States)

    Bett, J H; Dryburgh, L

    1981-06-01

    We examined the relationships between spontaneous heart rate (or conversely cycle length) changes and left ventricular diastolic dimensions and indices of systolic function in twenty-three subjects. In most there was clearly an inverse relationship between rate and these indices and nearly always a positive correlation between performance and end-diastolic dimension. Previously described relationship between heart rate and mean velocity of circumferential fiber shortening are applicable only when the heart rate is constant.

  10. Protection of LV system against lightning

    OpenAIRE

    Yordanova Nedyalkova, Greta

    2010-01-01

    Lightning is a natural hazard and one of the greatest local mysteries. Scientists have not fully understood the mechanism of lightning. It is one of the most beautiful displays in nature and one of the nature's most dangerous phenomenon known to man. Overvoltage due to lightning is a very important problem of LV systems. Some lightning flashes damage buildings and a few kill or injure people and animals, either directly or indirectly, by causing fire and explosions. The need for protect...

  11. Association Between Myocardial Mechanics and Ischemic LV Remodeling.

    Science.gov (United States)

    D'Elia, Nicholas; D'hooge, Jan; Marwick, Thomas H

    2015-12-01

    The outcomes associated with heart failure after myocardial infarction are still poor. Both global and regional left ventricular (LV) remodeling are associated with the progression of the post-infarct patient to heart failure, but although global remodeling can be accurately measured, regional LV remodeling has been more difficult to investigate. Preliminary evidence suggests that post-MI assessment of LV mechanics using stress and strain may predict global (and possibly regional) LV remodeling. A method of predicting both global and regional LV remodeling might facilitate earlier, targeted, and more extensive clinical intervention in those most likely to benefit from novel interventions such as cell therapy.

  12. Quantitative analysis of cardiac function: Comparison of electrocardiogram dual gated single photon emission tomography, planar radionuclide ventriculogram and contrast ventriculography in the determination of LV volume and ejection fraction

    Energy Technology Data Exchange (ETDEWEB)

    Ziada, G.; Abdel-Dayem, H.M.; Higazy, E.; Mohamed, M.M.; Bahar, R.; Hayat, N.; Yousof, A.M.

    1987-03-01

    A dual gated tomography (DGT) program for end systolic and end diastolic acquisition and subsequent processing for calculation of LVEF, end diastolic and end systolic volumes (EDV, ESV) has been evaluated in 20 healthy volunteers (25 years-40 years) and 45 patients (25 years-60 years): 20 with ischaemic heart disease and 25 with valvular heart disease (VHD). All had biplane multigated blood pool (MUGA) studies in the 40/sup 0/ LAO projection using in vivo /sup 99m/Tc-R BCs, immediately followed by DG. The results in the patients group were correlated with contrast ventriculography (CV). In the volunteer group, the normal values for LVEF, EDV and ESV measured with DGT were found to be 63%+10%, 91 ml + 6 ml and 30 ml + 6ml and r value for the LVEF=0.91 compared with MUGA. In the IHD group, r values compared with CV were 0.915 and 0.97 for the EDV and ESV and 0.934 for the LVEF. Compared with the MUGA, the r value for LVEF was 0.883. In the VHD group, r values were 0.98 for both the EDV and ESV and 0.948 for the LVEF (P<0.002) compared with CV and 0.789 for the LVEF compared with the MUGA. We feel that DGT is an accurate and reproducible technique for LV function measurements.

  13. Heart dimensions may influence the occurrence of the heart rate deflection point in highly trained cyclists

    Science.gov (United States)

    Lucia, A.; Carvajal, A.; Boraita, A.; Serratosa, L.; Hoyos, J.; Chicharro, J. L.

    1999-01-01

    OBJECTIVES: To determine whether the heart rate (HR) response to exercise in 21 highly trained cyclists (mean (SD) age 25 (3) years) was related to their heart dimensions. METHODS: Before performing an incremental exercise test involving a ramp protocol with workload increases of 25 W/min, each subject underwent echocardiographic evaluation of the following variables: left ventricular end diastolic internal diameter (LVIDd), left ventricular posterior wall thickness at end diastole (LVPWTd), interventricular septal wall thickness at end diastole (IVSTd), left ventricular mass index (LVMI), left atrial dimension (LAD), longitudinal left atrial (LLAD) and right atrial (LRAD) dimensions, and the ratio of early to late (E/A) diastolic flow velocity. RESULTS: The HR response showed a deflection point (HRd) at about 85% VO2MAX in 66.7% of subjects (D group; n = 14) and was linear in 33.3% (NoD group; n = 7). Several echocardiographic variables (LVMI, LAD, LLAD, LRAD) indicative of heart dimensions were similar in each group. However, mean LPWTd (p<0.01) and IVSTd (p<0.05) values were significantly higher in the D group. Finally, no significant difference between groups was found with respect to the E/A. CONCLUSIONS: The HR response is curvilinear during incremental exercise in a considerable number of highly trained endurance athletes-that is, top level cyclists. The departure of HR increase from linearity may predominantly occur in athletes with thicker heart walls. 


 PMID:10597846

  14. Application of MV/LV Transformers with OLTC for Increasing the PV Hosting Capacity Of LV Grids

    DEFF Research Database (Denmark)

    Hashemi Toghroljerdi, Seyedmostafa; Heckmann, Wolfram; Geibel, Dominik

    2015-01-01

    the operation of OLTC during high PV generation periods are investigated and the methods are applied to an LV feeder with an MV/LV transformer equipped by OLTC located in Felsberg, Germany. The potential interferences between OLTCs and two other overvoltage prevention methods, the demand side management (DSM...

  15. Relationships between body dimensions, body weight, age, gender, breed and echocardiographic dimensions in young endurance horses

    DEFF Research Database (Denmark)

    Trachsel, D S; Giraudet, A; Maso, D

    2016-01-01

    BACKGROUND: The heart's physiological adaptation to aerobic training leads to an increase in heart chamber size, and is referred to as the Athlete's heart. However, heart dimensions are also related to body weight (BWT), body size, growth and (in some species) breed. There are few published data...... functional indices did not. Although there was no gender difference for LV dimensions, females had larger LA dimensions. In terms of breed, Anglo-Arabians had the largest LV dimensions. Regression models indicated that the included explanatory factors had a weak influence on heart dimensions. Age, body...... may therefore reflect early adaptations linked to the initiation of endurance training....

  16. Value of dobutamine stress tissue Doppler in evaluation of LV ...

    African Journals Online (AJOL)

    Shaimaa Ahmed Mostafa

    2014-12-12

    Dec 12, 2014 ... Prosthetic valve disease. Complicated PCI. LVEF less .... annulus moved toward the cardiac apex due to longitudinal contraction of the LV. ..... to fibrotic tissue is too high and also, improved the integrity of cardiac myocyte cell ...

  17. Noninvasive LV pressure estimation using subharmonic emissions from microbubbles.

    Science.gov (United States)

    Dave, Jaydev K; Halldorsdottir, Valgerdur G; Eisenbrey, John R; Raichlen, Joel S; Liu, Ji-Bin; McDonald, Maureen E; Dickie, Kris; Wang, Shumin; Leung, Corina; Forsberg, Flemming

    2012-01-01

    To develop a new noninvasive approach to quantify left ventricular (LV) pressures using subharmonic emissions from microbubbles, an ultrasound scanner was used in pulse inversion grayscale mode; unprocessed radiofrequency data were obtained with pulsed wave Doppler from the aorta and/or LV during Sonazoid infusion. Subharmonic data (in dB) were extracted and processed. Calibration factor (mm Hg/dB) from the aortic pressure was used to estimate LV pressures. Errors ranged from 0.19 to 2.50 mm Hg when estimating pressures using the aortic calibration factor, and were higher (0.64 to 8.98 mm Hg) using a mean aortic calibration factor. Subharmonic emissions from ultrasound contrast agents have the potential to noninvasively monitor LV pressures.

  18. Formation and characterization of FeLV iscoms.

    NARCIS (Netherlands)

    L. Akerblom; K. Strö mstedt; S. Hö glund; A.D.M.E. Osterhaus (Albert); B. Morein (Bror)

    1989-01-01

    textabstractImmunostimulating complexes (ISCOMs) have been prepared from feline leukaemia virus (FeLV) envelope proteins. The ISCOMs were characterized biochemically in SDS-polyacrylamide gel electrophoresis showing the presence of proteins of estimated molecular weights of 15,000, 27,000 and 70,000

  19. Avoided losses on LV networks as a result of microgeneration

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Paulo Moises [Escola Superior Tecnologia Viseu, Instituto Politecnico Viseu, Campus Politecnico Repeses, 3504-510 Viseu (Portugal); Matos, Manuel A. [INESC Porto, Faculdade de Engenharia da Universidade do Porto, Porto (Portugal)

    2009-04-15

    In the scope of the discussions about microgeneration (and microgrids), the avoided electrical losses are often pointed out as an important value to be credited to those entities. Therefore, methods to assess the impact of microgeneration on losses must be developed in order to support the definition of a suitable regulatory framework for the economic integration of microgeneration on distribution networks. This paper presents an analytical method to quantify the value of avoided losses that microgeneration may produce on LV networks. Intervals of expected avoided losses are used to account for the variation of avoided losses due to the number, size and location of microgenerators, as well as for the kind of load distribution on LV networks. (author)

  20. A Dynamic and Heuristic Phase Balancing Method for LV Feeders

    Directory of Open Access Journals (Sweden)

    Samad Taghipour Boroujeni

    2016-01-01

    Full Text Available Due to the single-phase loads and their stochastic behavior, the current in the distribution feeders is not balanced. In addition, the single-phase loads are located in different positions along the LV feeders. So the amount of the unbalanced load and its location affect the feeder losses. An unbalanced load causes the feeder losses and the voltage drop. Because of time-varying behavior of the single-phase loads, phase balancing is a dynamic and combinatorial problem. In this research, a heuristic and dynamic solution for the phase balancing of the LV feeders is proposed. In this method, it is supposed that the loads’ tie could be connected to all phases through a three-phase switch. The aim of the proposed method is to make the feeder conditions as balanced as possible. The amount and the location of single-phase loads are considered in the proposed phase balancing method. Since the proposed method needs no communication interface or no remote controller, it is inexpensive, simple, practical, and robust. Applying this method provides a distributed and dynamic phase balancing control. In addition, the feasibility of reducing the used switches is investigated. The ability of the proposed method in the phase balancing of the LV feeders is approved by carrying out some simulations.

  1. Fatores Prognósticos para o Óbito Perinatal em Gestações com Diástole Zero ou Reversa na Dopplervelocimetria das Artérias Umbilicais Prognostic Parameters for Perinatal Death in Pregnancies with Absent or Reversed End-Diastolic Flow Velocity in the Umbilical Arteries

    Directory of Open Access Journals (Sweden)

    Roseli Mieko Yamamoto

    2000-01-01

    Full Text Available Objetivos: estudar os fatores prognósticos para o óbito perinatal em gestações com diagnóstico de diástole zero (DZ ou reversa (DR na dopplervelocimetria das artérias umbilicais. Métodos: foram analisadas retrospectivamente 204 gestantes com DZ ou DR, sendo realizados os exames de cardiotocografia, perfil biofísico fetal, índice do líquido amniótico e dopplervelocimetria do ducto venoso e das artérias umbilicais, uterinas, aorta e cerebral média. Em 170 casos foi aplicado o modelo de regressão logística para determinar a variável com melhor acurácia na predição do óbito perinatal. Resultados: a mortalidade foi de 28 casos de óbito fetal (13,7% e 45 de óbito pós-natal (22,1%. Houve correlação significativa entre os óbitos e as variáveis analisadas. A proporção de óbitos no grupo com recém-nascidos de peso inferior a 1.000 g foi de 74,7% e no grupo com idade gestacional inferior a 31 semanas, de 66,3%. Na regressão logística, o peso do recém-nascido foi a melhor variável capaz de predizer o óbito perinatal (pPurpose: to study the prognostic parameters for perinatal death in pregnancies with absent or reversed end-diastolic flow velocity on umbilical artery dopplervelocimetry. Methods: two hundred and four pregnancies were retrospectively reviewed. The methods used were cardiotocography, fetal biophysical profile, amniotic fluid index and dopplervelocimetry of ductus venosus, fetal aorta, middle cerebral artery, umbilical arteries and uterine artery. The logistic regression model was applied to one hundred and seventy cases in order to determine the most accurate variable for predicting perinatal death. Results: the mortality rates were: 28 cases of intrauterine fetal death (13.7% and 45 neonatal deaths (22.1%. A statistically significant correlation was found between death and the studied variables. The perinatal death rate in the group with birth weight below 1,000 g was 74.7%, and in the group with

  2. Cardiac resynchronization induces major structural and functional reverse remodeling in patients with New York Heart Association class I/II heart failure

    DEFF Research Database (Denmark)

    St John Sutton, Martin; Ghio, Stefano; Plappert, Ted;

    2009-01-01

    BACKGROUND: Cardiac resynchronization therapy (CRT) improves LV structure, function, and clinical outcomes in New York Heart Association class III/IV heart failure with prolonged QRS. It is not known whether patients with New York Heart Association class I/II systolic heart failure exhibit left...... ventricular (LV) reverse remodeling with CRT or whether reverse remodeling is modified by the cause of heart failure. METHODS AND RESULTS: Six hundred ten patients with New York Heart Association class I/II heart failure, QRS duration > or =120 ms, LV end-diastolic dimension > or =55 mm, and LV ejection...... reduction in LV end-diastolic and end-systolic volume indexes and a 3-fold greater increase in LV ejection fraction in patients with nonischemic causes of heart failure. CONCLUSIONS: CRT in patients with New York Heart Association I/II resulted in major structural and functional reverse remodeling at 1 year...

  3. 77 FR 21620 - Notice of the Buy America Waiver Request for Vossloh 101-LV Concrete Ties

    Science.gov (United States)

    2012-04-10

    ... Federal Railroad Administration Notice of the Buy America Waiver Request for Vossloh 101-LV Concrete Ties... requirements for the purchase of Vossloh 101-LV concrete ties, which contain certain components not... consist of the installation of Vossloh 101-LV concrete ties. FRA has received this request from the four...

  4. Voltage rise mitigation for solar PV integration at LV grids

    DEFF Research Database (Denmark)

    Yang, Guangya; Marra, Francesco; Juamperez Goñi, Miguel Angel

    2015-01-01

    Solar energy from photovoltaic (PV) is among the fastest developing renewable energy systems worldwide. Driven by governmental subsidies and technological development, Europe has seen a fast expansion of solar PV in the last few years. Among the installed PV plants, most of them are situated...... at the distribution systems and bring various operational challenges such as power quality and power flow management. The paper discusses the modelling requirements for PV system integration studies, as well as the possible techniques for voltage rise mitigation at low voltage (LV) grids for increasing PV penetration...

  5. Study on the Correlation Between Absent End-diastolic Velocity in Fetal Umbilical Artery and Pregnancy Outcome%胎儿脐动脉舒张末期血流缺失与妊娠结局的相关性研究

    Institute of Scientific and Technical Information of China (English)

    孙江丽; 于海容

    2012-01-01

    [目的]探讨胎儿脐动脉舒张末期血流缺失(AEDV)与妊娠结局的关系.[方法]产前常规应用脉冲多普勒技术行胎儿脐动脉血流频谱检测,确诊为AEDV孕妇36例,分析AEDV与妊娠合并症、妊娠结局的关系.[结果]36例AEDV病例中,重度子痫前期69.4%(25/36),胎儿生长受限80.6%(29/36),羊水过少22.2%(8/36),妊娠期肝内胆管淤积症11.1%(4/36),妊娠期糖尿病8.3%(3/36);胎儿先天畸形发生率为16.7%(6 / 36),病死率55.6%(20 /36 ).[结论]脐动脉舒张末期血流缺失是脐动脉血流阻力增高的特有表现,表明胎儿-胎盘循环障碍,妊娠合并症增多,胎儿预后不良,临床应给予高度重视.%[Objective] To explore the relationship between absent end diastolic velocity (AEDV) in theumbilical artery and the pregnancy outcome. [Methods]Pulse Doppler was used to measure fetal umbilical ar tery flow. A total of 36 pregnant women were diagnosed as AEDV. The correlation of AEDV with pregnancy complications and pregnancy outcomes was analyzed. [Results] Among 36 AEDV cases, there were 25 cases of severe preeclampsia(69. 4%) , 29 cases of intrauterine growth retardation(IUGR) (80. 6%) , 8 cases of oli gohydramnios(22. 2%) , 4 cases of interahepatic cholestasis of pregnancy(ll. 1%) and 3 cases of gestational diabetes mellitus(8. 3%). The incident rate of fetal malformation was 16. 7% (6/36) and the mortality rate was 55. 6%(20/36). [Conclusion]AEDV in the umbilical artery is the unique performance of abnormally in creased resistance of blood flow in the umbilical artery, which suggests fetal placenta circulation barrier, more pregnancy complications and poor prognosis of fetus. Therefore AEDV should be paid attention.

  6. Cloning and characterization of a novel hemocyanin variant LvHMCV4 from shrimp Litopenaeus vannamei.

    Science.gov (United States)

    Lu, Xin; Lu, Hui; Guo, Lingling; Zhang, Zehui; Zhao, Xianliang; Zhong, Mingqi; Li, Shengkang; Zhang, Yueling

    2015-10-01

    Recently, we found 3 variants of hemocyanin subunit with higher molecular weight in shrimp Litopenaeus vannamei (Named as LvHMCV1-3). In this study, a novel L. vannamei hemocyanin variant (Named as LvHMCV4) was further cloned and characterized. Bioinformatic analysis predicted that LvHMCV4 contains one open reading frame of 2137 bp and encodes a polypeptide of 678 amino acids. It shares 84-99% cDNA sequences identity to that of the classical form of L. vannamei hemocyanin (LvHMC, AJ250830.1) and LvHMCV1-3. LvHMCV4 possesses a conserved structure characteristic of the hemocyanin family and can be clustered into one branch along with other arthropod hemocyanins in a phylogenetic tree. Further, the full-length DNA of LvHMCV4 contains 2660 bp and two introns, which are located at the 80-538 bp and 2063-2227 bp regions, respectively. In addition, the mRNA transcript of LvHMCV4 was expressed highly in the hepatopancreas, lymphoid, brain and hemocytes, and weakly in the heart, intestine and gill, while no expression was found in the muscle, stomach and gut. Infection by Escherichia coli K12, Vibrio parahaemolyticus, Vibrio alginolyticus, Vibrio fluvialis, Streptococcus pyogenes or Staphylococcus aureus up-regulated significantly LvHMCV4 mRNA expression in the hepatopancreas. Furthermore, the recombinant protein of LvHMCV4 (rLvHMCV4) was prepared, which showed agglutination activities against six pathogenic bacteria at concentrations ranging from 15.6 to 125 μg/ml. When co-injected with V. parahaemolyticus in L.vannamei, rLvHMCV4 significantly increased the survival rate after 48 h injection. Together, these studies suggested that hemocyanin variant, LvHMCV4, might be involved in shrimp resistance to pathogenic infection.

  7. Efficient Control of Active Transformers for Increasing the PV Hosting Capacity of LV Grids

    DEFF Research Database (Denmark)

    Hashemi Toghroljerdi, Seyedmostafa; Østergaard, Jacob; Degner, Thomas

    2016-01-01

    on decreasing the voltage rise along LV feeders, and the potential of active medium voltage to low voltage (MV/LV) transformers for overvoltage prevention has not been thoroughly investigated. This paper presents the application of active MV/LV transformers for increasing the PV hosting capacity of LV grids...... increase the PV hosting capacity of the grid, while eliminating the need for a complex and centralized controller. The voltages of specific locations or the grid state estimations provide adequate data for adjustments of the droop parameters. The simulations and field test results associated...

  8. Dimension quotients

    OpenAIRE

    Hartl, M; Mikhailov, R.; Passi, I. B. S.

    2008-01-01

    We present two approaches, one homological and the other simplicial, for the investigation of dimension quotients of groups. The theory is illustrated, in particular, with a conceptual discussion of the fourth and fifth dimension quotients.

  9. Assessment of the LV-S2 & LV-S3 Stack Sampling Probe Locations for Compliance with ANSI/HPS N13.1-1999

    Energy Technology Data Exchange (ETDEWEB)

    Glissmeyer, John A.; Antonio, Ernest J.; Flaherty, Julia E.; Amidan, Brett G.

    2014-09-30

    This document reports on a series of tests conducted to assess the proposed air sampling locations for the Hanford Tank Waste Treatment and Immobilization Plant (WTP) Group 1-2A exhaust stacks with respect to the applicable criteria regarding the placement of an air sampling probe. The LV-C2, LV-S2, and LV-S3 exhaust stacks were tested together as a group (Test Group 1-2A). This report only covers the results of LV-S2 and LV-S3; LV-C2 will be reported on separately. Federal regulations1 require that a sampling probe be located in the exhaust stack according to the criteria established by the American National Standards Institute/Health Physics Society (ANSI/HPS) N13.1-1999, Sampling and Monitoring Releases of Airborne Radioactive Substances from the Stack and Ducts of Nuclear Facilities. 2 These criteria address the capability of the sampling probe to extract a sample that represents the effluent stream.

  10. Relationship Among Plasma Brain Natriuretic Peptide (BNP) Levels, Left Ventricular Ejection Fraction (LVEF) and Left Ventricular End-Diastolic Diameter(LVEDD) in Patients with Heart Failure%心衰患者脑钠肽与左室射血分数等参数的研究

    Institute of Scientific and Technical Information of China (English)

    胡丙清; 陈森

    2011-01-01

    目的 研究慢性稳定性及失代偿性心力衰竭(选择心功能Ⅱ、Ⅲ、Ⅳ级)患者血浆中脑钠肽(BNP)水平的差异及其与左室射血分数(LVEF)、左室舒张末期内径(LVEDD)之间的相关性.方法 选择心力衰竭患者96例,入院后均经心脏彩超检查.按NYHA分级,Ⅱ级40例,其中稳定性心衰14例,失代偿性心衰26例;Ⅲ级40例,其中稳定性心衰16例,失代偿性心衰24例;Ⅳ级16例,其中稳定性心衰4例,失代偿性心衰12例.采用美国雅培12000SR全自动化学发光分析仪测定血浆BNP水平.结果 BNP数值在NYHA分级Ⅱ、Ⅲ、Ⅳ各组间(包括稳定期、失代偿期)差异有统计学意义(P<0.05).LVEDD及LVEF在慢性稳定性心衰组各分级间差异有统计学意义(P<0.05),而LVEDD及LVEF在失代偿性心衰组各分级间差异无统计学意义(P>0.05).结论 脑钠肽的升高与NYHA分级成正相关,左室射血分数及舒张末期内径与慢性稳定性心衰分级成正相关,与慢性失代偿性心衰无明显相关性.%Objective To investigate the level differences of plasma brain natriuretic peptide( BNP) in patients with chronic stable and decompensation heart failure and their relationship among BNP,left ventricular ejection fraction(LVEF) and left ventricular end-diastolic diameter(LVEDD). Methods Ninety-six patients with heart failure were examined by UCG after admission , and they were divided into three groups according to NYHA' s heart function class criterion: NYHA class II group 40 cases, including chronic stable heart failure 14 cases; decompensation heart failure 26 cases; NYH A class IQ group 40 cases; including chronic stable heart failure 16 cases;decompensation heart failure 24 cases;NYHA class IV group 16 cases,including chronic stable heart failure 4 cases; heart failure 12 cases. The concentration of BNP was measured by Achitect I2000SR full-automatic chemiluminesent immunoassay ( CLIA). Results The concentration of BNP between NYHA class

  11. LvDJ-1 plays an important role in resistance against Vibrio alginolyticus in Litopenaeus vannamei.

    Science.gov (United States)

    Huang, Mingzhu; Liu, Yuan; Xie, Chenying; Wang, Wei-Na

    2015-05-01

    DJ-1 was first identified as an oncogene that transformed mouse NIH3T3 cells in cooperation with activated Ras. It has since exhibited a variety of functions in a range of organisms. In this study, the DJ-1 gene in Litopenaeus vannamei (LvDJ-1) was identified and characterized. A recombinant protein LvDJ-1 was produced in Pichia pastoris. LvDJ-1 expression in vivo was knocked down by dsRNA-mediated RNA interference (RNAi), which led to significantly decreased levels of LvDJ-1 mRNA and protein. When the L. vannamei were challenged with RNAi and Vibrio alginolyticus, the transcription and expression of copper zinc superoxide dismutase (LvCZSOD) in the hepatopancreas were dramatically lower in shrimp with knocked down LvDJ-1 than in controls. Transcription and expression of P53 (LvP53) were significantly higher in shrimp lacking LvDJ-1 than in controls. Hepatopancreas samples were analyzed using real time polymerase chain reaction and Western blot. Moreover, blood samples from the shrimp, assessed with flow cytometry, showed significant increases in respiratory burst and apoptosis in those lacking LvDJ-1 compared to the controls. Cumulative mortality in the shrimp lacking LvDJ-1 was significantly different from that in the control group after challenge with V. alginolyticus. Altogether, the results prove that LvDJ-1 regulates apoptosis and antioxidant activity, and that these functions play an important role in L. vannamei resistance against V. alginolyticus.

  12. Application of SPCALC for chemical and thermodynamic speciation of fluids -example for wells LV-4A, LV-11 and LV-13, Las Tres Virgenes geothermal field, BCS; Aplicacion del SPCALC en la especiacion quimica y termodinamica de fluidos: ejemplo del caso de los pozos LV-4A, LV-11 y LV-13, del campo geotermico de Las Tres Virgenes, BCS

    Energy Technology Data Exchange (ETDEWEB)

    Viggiano Guerra, J.C.; Sandoval Medina, F.; Flores Armenta, M.C. [Comision Federal de Electricidad, Gerencia de Proyectos Geotermoelectricos, Morelia, Michoacan (Mexico)]. E-mail: fernando.sandoval@cfe.gob.mx, E-mail: magaly.flores@cfe.gob.mx; Perez, R.J. [Universidad de Calgary (Canada); Gonzalez Partida, E. [Universidad Nacional Autonoma de Mexico, Centro de Geociencias, Mexico, D.F. (Mexico)

    2009-01-15

    SPCALC is an excellent software application providing chemical and multi-phase speciation for geothermal fluids. Recently it was acquired by the Comision Federal de Electricidad (CFE) through a contract with the National Autonomous University of Mexico (UNAM) and the University of Calgary, Canada. Software methodology consists of calculating thermodynamic variables, such as activity (a) and fugacity (f) of chemical species, as well as the saturation indices (log Q/K) of mineral phases of the reservoir. In other words, it models the thermodynamic conditions of the reservoir (pH among other) and simulates the fluid-corrosion rate. This allows the software to foresee scaling and corrosion. In this paper, pervasive fluids in Cretaceous granitic rocks penetrated by wells LV-4A, LV-11 and LV-13 in Las Tres Virgenes geothermal field, BCS, are modeled, starting with chemical analyses. The more important ratios among activities [those which influence the fluid-rock interaction (i.e. {sup a}K{sup +}/{sup a}H{sup +}, {sup a}Ca{sup ++}/{sup a}H{sup +}, {sup a}Na{sup +}/{sup a}H{sup +}, {sup a}Mg{sup ++}/{sup a}H{sup +}) and whose results are the minerals visible under a microscope] are graphed in balance diagrams compatible with the pressure (P) and temperature (T) conditions in the reservoir. Epidote (zoisite) is the mineral found in congruent equilibrium with the system. The main mineral association at those conditions (200-250 degrees Celsius and {approx}18 bar), as observed in the well cuttings, is calcite+illite-quartz{+-}epidote, which is explained by the hydrolithic reactions that form replacement calcite in the presence of CO{sub 2}, thus restricting the formation of epidote and eventually eliminating it. The process enhances the CO{sub 2} molarity in the residual fluid, even up to {sup m}CO{sub 2} 1, which means the CO{sub 2} can be diluted back into fluid and intervene again in the process of calcite formation (2HCO{sub 3}{sup -} + Ca{sup ++} = calcite + H{sub 2}O

  13. Fatores preditores para o óbito neonatal em gestações com diástole zero ou reversa na doplervelocimetria da artéria umbilical Predictor parameters of neonatal death in gestations with absent or reverse end-diastolic flow in the umbilical artery doppler velocimetry

    Directory of Open Access Journals (Sweden)

    Manoel Martins Neto

    2010-07-01

    Full Text Available OBJETIVO: avaliar os fatores de risco antenatais e pós-natais para o óbito neonatal em gestações com diástole zero (DZ ou reversa (DR na doplervelocimetria da artéria umbilical. MÉTODOS: estudo transversal, retrospectivo, inferencial, a partir de 48 prontuários de gestações únicas com DZ ou DR, idade gestacional entre 24 e 34 semanas, em uma maternidade no Nordeste do Brasil. A média de idade foi de 27,3 anos (DP: 7,9. Vinte (41,7% eram primigestas. Síndromes hipertensivas foram observadas em 44 (91,7% casos. Trinta e cinco (72,9% apresentavam DZ e 13 (27,1% DR. Procedeu-se inicialmente à análise univariada (teste t de Student e teste Exato de Fisher, relacionando os parâmetros com o desfecho avaliado (óbito neonatal. As variáveis que apresentaram associação significativa foram incluídas no modelo de regressão logística (Estatística de Wald. O nível de significância utilizado foi de 5%. RESULTADOS: a mortalidade perinatal foi de 64,6% (31/48. Ocorreram cinco óbitos fetais e 26 neonatais. A média de idade gestacional no momento do diagnóstico foi de 27,9 (DP: 2,8 semanas. A resolução da gestação antes de 24 horas após o diagnóstico ocorreu em 52,1% dos casos. Parto abdominal foi realizado em 85,4% dos casos. Os recém-nascidos pesaram em média 975,9 g (DP: 457,5. Vinte e quatro (57,1% apresentaram Apgar menor que 7 no primeiro minuto e 21,4%, no quinto. A idade gestacional no momento do diagnóstico, o peso ao nascer e o Apgar de primeiro minuto revelaram-se variáveis significativamente relacionadas com o óbito neonatal (valores de p foram, respectivamente, 0,008; 0,004 e 0,020. As razões de chance foi de 6,6; 25,3 e 13,8 para o óbito neonatal, quando o diagnóstico foi estabelecido até a 28ª semana, peso PURPOSE: to evaluate the antenatal and postnatal risk factors of neonatal death in pregnancies with absent (DZ or reverse (DR end-diastolic flow in the umbilical artery. METHODS: a cross

  14. Relation between cardiac dimensions and peak oxygen uptake

    Directory of Open Access Journals (Sweden)

    Mosén H

    2010-02-01

    Full Text Available Abstract Background Long term endurance training is known to increase peak oxygen uptake ( and induce morphological changes of the heart such as increased left ventricular mass (LVM. However, the relationship between and the total heart volume (THV, considering both the left and right ventricular dimensions in both males and females, is not completely described. Therefore, the aim of this study was to test the hypothesis that THV is an independent predictor of and to determine if the left and right ventricles enlarge in the same order of magnitude in males and females with a presumed wide range of THV. Methods and Results The study population consisted of 131 subjects of whom 71 were athletes (30 female and 60 healthy controls (20 female. All subjects underwent cardiovascular MR and maximal incremental exercise test. Total heart volume, LVM and left- and right ventricular end-diastolic volumes (LVEDV, RVEDV were calculated from short-axis images. was significantly correlated to THV, LVM, LVEDV and RVEDV in both males and females. Multivariable analysis showed that THV was a strong, independent predictor of (R2 = 0.74, p 2 = 0.87, p Conclusion Total heart volume is a strong, independent predictor of maximal work capacity for both males and females. Long term endurance training is associated with a physiologically enlarged heart with a balance between the left and right ventricular dimensions in both genders.

  15. Exhaustion of the Frank-Starling mechanism in conscious dogs with heart failure induced by chronic coronary microembolization.

    Science.gov (United States)

    Gill, Robert M; Jones, Bonita D; Corbly, Angela K; Ohad, Dan G; Smith, Gerald D; Sandusky, George E; Christe, Michael E; Wang, Jie; Shen, Weiqun

    2006-07-04

    The role of the Frank-Starling mechanism in the regulation of cardiac systolic function in the ischemic failing heart was examined in conscious dogs. Left ventricular (LV) dimension, pressure and systolic function were assessed using surgically implanted instrumentations and non-invasive echocardiogram. Heart failure was induced by daily intra-coronary injections of microspheres for 3-4 weeks via implanted coronary catheters. Chronic coronary embolization resulted in a progressive dilation of the left ventricle (12+/-3%), increase in LV end-diastolic pressure (118+/-19%), depression of LV dP/dt(max) (-19+/-4%), fractional shortening (-36+/-7%), and cardiac work (-60+/-9%), and development of heart failure, while the LV contractile response to dobutamine was depressed. A brief inferior vena caval occlusion in dogs with heart failure decreased LV preload to match the levels attained in their control state and caused a further reduction of LV dP/dt(max), fractional shortening, stroke work and cardiac work. Moreover, in response to acute volume loading, the change in the LV end-diastolic dimension-pressure (DeltaLVEDD-DeltaLVEDP) curve in the failing heart became steeper and shifted significantly to the left, while the increases in LV stroke work and cardiac work were blunted. Thus, our results suggest that the Frank-Starling mechanism is exhausted in heart failure and unable to further respond to increasing volume while it plays an important compensatory role in adaptation to LV dysfunction in heart failure.

  16. Gorenstein dimensions

    CERN Document Server

    Christensen, Lars Winther

    2000-01-01

    This book is intended as a reference for mathematicians working with homological dimensions in commutative algebra and as an introduction to Gorenstein dimensions for graduate students with an interest in the same. Any admirer of classics like the Auslander-Buchsbaum-Serre characterization of regular rings, and the Bass and Auslander-Buchsbaum formulas for injective and projective dimension of f.g. modules will be intrigued by this book's content. Readers should be well-versed in commutative algebra and standard applications of homological methods. The framework is that of complexes, but all major results are restated for modules in traditional notation, and an appendix makes the proofs accessible for even the casual user of hyperhomological methods.

  17. Inferring microbial interaction networks from metagenomic data using SgLV-EKF algorithm.

    Science.gov (United States)

    Alshawaqfeh, Mustafa; Serpedin, Erchin; Younes, Ahmad Bani

    2017-03-27

    Inferring the microbial interaction networks (MINs) and modeling their dynamics are critical in understanding the mechanisms of the bacterial ecosystem and designing antibiotic and/or probiotic therapies. Recently, several approaches were proposed to infer MINs using the generalized Lotka-Volterra (gLV) model. Main drawbacks of these models include the fact that these models only consider the measurement noise without taking into consideration the uncertainties in the underlying dynamics. Furthermore, inferring the MIN is characterized by the limited number of observations and nonlinearity in the regulatory mechanisms. Therefore, novel estimation techniques are needed to address these challenges. This work proposes SgLV-EKF: a stochastic gLV model that adopts the extended Kalman filter (EKF) algorithm to model the MIN dynamics. In particular, SgLV-EKF employs a stochastic modeling of the MIN by adding a noise term to the dynamical model to compensate for modeling uncertainties. This stochastic modeling is more realistic than the conventional gLV model which assumes that the MIN dynamics are perfectly governed by the gLV equations. After specifying the stochastic model structure, we propose the EKF to estimate the MIN. SgLV-EKF was compared with two similarity-based algorithms, one algorithm from the integral-based family and two regression-based algorithms, in terms of the achieved performance on two synthetic data-sets and two real data-sets. The first data-set models the randomness in measurement data, whereas, the second data-set incorporates uncertainties in the underlying dynamics. The real data-sets are provided by a recent study pertaining to an antibiotic-mediated Clostridium difficile infection. The experimental results demonstrate that SgLV-EKF outperforms the alternative methods in terms of robustness to measurement noise, modeling errors, and tracking the dynamics of the MIN. Performance analysis demonstrates that the proposed SgLV-EKF algorithm

  18. Assessment of the Effect of Cardiomyocyte Transplantation on Left Ventricular Remodeling and Function in Post-Infarction Wister Rats by Using High-frequency Ultrasound

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jing; XIE Mingxing; WANG Xinfang; L(U) Qing; LANG Mingjian; DENG Binhua

    2007-01-01

    The effects of cardiomyocyte grafting on left ventricular (LV) remodeling and function in rats with chronic myocardial infarction were evaluated using high-frequency ultrasound. Chronic myocardial infarction was induced in 50 Wister rats by ligating the left anterior descending artery. They were randomized into two groups: a trial group that received neonatal rat cardiomyocyte trans- plantation (n=25) and a control group which were given intramyocardial injection of culture medium (n=25). The left ventricular (LV) geometry and function were evaluated by high-frequency ultrasound before and 4 weeks after the cell transplantation. After the final evaluation, all rats were sacrificed for histological study. The results showed that 4 weeks after the cell transplantation, as compared with the control group, the LV end-systolic dimension, end-diastolic dimension, end-systolic volume and end-diastolic volume were significantly decreased and the LV anterior wall end-diastolic thickness, LV ejection fraction and fractional shortening were significantly increased in the trial group (P<0.01). Histological study showed that transplanted neonatal rat cardiomyocytes were found in all host hearts and identified by Brdu staining. It was suggested that transplantation of neonatal rat cardiomyocytes can reverse cardiac remodeling and improve heart function in chronic myocardial infarction rats. High-frequency ultrasound can be used as a reliable technique for the non-invasive evaluation of the effect of cardiomyocyte transplantation.

  19. N-terminal pro brain natriuretic peptide in arterial hypertension--a marker for left ventricular dimensions and prognosis

    DEFF Research Database (Denmark)

    Hildebrandt, Per; Boesen, Mikael; Olsen, Michael

    2004-01-01

    In arterial hypertension risk factor evaluation, including LV mass measurements, and risk stratification using risk charts or programs, is generally recommended. In heart failure NT-proBNP has been shown to be a marker of LV dimensions and of prognosis. If the same diagnostic and prognostic value...... is present in arterial hypertension, risk factor evaluation would be easier. In 36 patients with arterial hypertension, electrocardiographic LV hypertrophy and preserved left ventricular function, NT-proBNP was eight-fold higher than in healthy subjects. The log NT-proBNP correlated with LV mass index (R=0...... and preserved LV function demonstrated that NT-proBNP was a very strong prognostic marker, especially combined with a history of cardiovascular disease. Patients with high NT-proBNP and known cardiovascular disease had a seven-fold increase in CV events compared to patients with low NT-proBNP and no CV disease...

  20. 三洋推出Easy Radio IC系列LV24000PL

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    三洋(Sanyo)公司日前推出Easy Radio IC系列LV24000PL。LV24000PL是一款不需要使用外部元器件的便携式Device用FM调谐器芯片,尺寸仅约5mm×5mm×0.8mm,尺寸缩减为原来的六分之一,适用于手机、PDA等便携式产品。

  1. La piattaforma POS/LV di Applanix nelle applicazioni di laser scanner cinematico

    Directory of Open Access Journals (Sweden)

    Domenico Santarsiero

    2008-03-01

    Full Text Available The Applanix POS/LV platform in cinematic laser scanner applicationsOn the 11th of march the GEOmedia editorial unit had the pleasure of hosting a technical meeting dedicated to the Applanix LANDMark new Position and Orientation System for Land Vehicles (POS/LVfield test. The meeting, which is part of an italian tour organized by Louis Nastro (Applanix Director of Land Products and Terenzio Mariani (Sales manager for Italy, helped to test the functionalities of a complete POS/LV system equipped with a laser and an imaging acquisition software installed on board of a SUV.

  2. Characterization and DNA sequence of the mobilization region of pLV22a from Bacteroides fragilis.

    OpenAIRE

    Novicki, T. J.; Hecht, D. W.

    1995-01-01

    A 4.2-kb plasmid (pLV22a) native to Bacteroides fragilis LV22 became fused to a transfer-deficient Bacteroides spp.-Escherichia coli shuttle vector by an inverse transposition event, resulting in a transferrable phenotype. The transfer phenotype was attributable to pLV22a, which was also capable of mobilization within E. coli when coresident with the IncP beta R751 plasmid. Transposon mutagenesis with Tn1000 localized the mobilization region to a 1.5-kb DNA segment in pLV22a. The mobilization...

  3. 3D quantitative visualization of altered LV wall thickening dynamics caused by coronary microembolization

    Science.gov (United States)

    Eusemann, Christian D.; Mohlenkamp, Stefan; Ritman, Erik L.; Robb, Richard A.

    2001-05-01

    Regional heart wall dynamics has been shown to be a sensitive indicator of LV wall ischemia. Rates of local LV wall thickening during a cardiac cycle can be measured and illustrated using functional parametric mappings. This display conveys the spatial distribution of dynamic strain in the myocardium and thereby provides a rapid qualitative appreciation of the severity and extent of the ischemic region. 3D reconstructions were obtained in an anesthetized pig from 8 adjacent, shortaxis, slices of the left ventricle imaged with an Electron Beam Computer Tomograph at 11 time points through one complete cardiac cycle. The 3D reconstructions were obtained before and after injection of 100 micrometer microspheres into the Left Anterior Descending (LAD) coronary artery. This injection causes microembolization of LAD artery branches within the heart wall. The image processing involved radially dividing the tomographic images of the myocardium into small subdivisions with color encoding of the local magnitude of regional thickness or regional velocities of LV wall thickening throughout the cardiac cycle. We compared the effectiveness of animation of wall thickness encoded in color versus a static image of computed rate of wall thickness change in color. The location, extent and severity of regional wall akinesis or dyskinesis, as determined from these displays, can then be compared to the region of embolization as indicated by the distribution of altered LV wall perfusion.

  4. Extinction in the Galaxy from surface brightnesses of ESO-LV galaxies : Testing "standard" extinction maps

    NARCIS (Netherlands)

    Choloniewski, J.; Valentijn, E. A.

    2003-01-01

    A new method for the determination of the extinction in the Galaxy is proposed. The method uses surface brightnesses of external galaxies in the B and R-bands. The observational data have been taken from the ESO-LV galaxy catalog. As a first application of our model we derive the ratio of R-band to

  5. Revisión diagramas de equilibrio Txy (LV y LLV)

    OpenAIRE

    Reyes Labarta, Juan Antonio

    2007-01-01

    Este tema se encarca en el contexto del estudio del equilibrio entre fases líquido-vapor. Se muestra de forma cualitativa diferentes ejemplos de diagramas de equilibrio LV, temperatura-composición (a presión constante), así como bibliografía relacionada. Universidad de Alicante. Dpto. Ingeniería Química

  6. Voltage unbalance mitigation in LV networks using three-phase PV systems

    DEFF Research Database (Denmark)

    Garcia Bajo, Cristina; Hashemi Toghroljerdi, Seyedmostafa; Bækhøj Kjær, Søren;

    2015-01-01

    In this paper a new method is proposed to mitigate voltage unbalance caused by single-phase solar inverters in low voltage (LV) networks. The method is based on uneven reactive power absorption and injection by three-phase solar inverters. Independent control of each phase is performed to achieve...

  7. Identification and function analysis of a novel vascular endothelial growth factor, LvVEGF3, in the Pacific whiteleg shrimp Litopenaeus vannamei.

    Science.gov (United States)

    Wang, Zhiwei; Li, Shihao; Li, Fuhua; Xie, Shijun; Xiang, Jianhai

    2016-10-01

    VEGF signaling pathway is first discovered in mammals and proved to play important roles in the biological processes of angiogenesis, tumor migration, cell differentiation, apoptosis, host-virus interaction etc. Three members in the VEGF signaling pathway, including LvVEGFR, LvVEGF1 and LvVEGF2 in shrimp have been proved to be related with WSSV infection in our previous studies. Currently, another member of VEGF family, LvVEGF3, was isolated and its function during the WSSV infection of shrimp was studied. The deduced amino acid sequence of LvVEGF3 contained a signal peptide, a typical PDGF/VEGF domain and a cysteine-knot motif (CXCXC). Tissue distribution analysis showed that LvVEGF3 was predominantly expressed in hemocytes. The transcriptional level of LvVEGF3 in hemocytes was apparently up-regulated during WSSV infection. Silencing of LvVEGF3 with double-stranded RNA caused a reduction of the cumulative mortality rate of shrimp during WSSV infection. The expression of LvVEGFR was apparently down-regulated after LvVEGF3 silencing and up-regulated after injection of recombinant LvVEGF3 protein, suggesting an interaction between LvVEGF3 and LvVEGFR. Furthermore, the interaction between LvVEGFR and LvVEGF3 was confirmed using the yeast two-hybrid system. The results provided new insights into understanding the role of VEGF signaling pathway during virus infection.

  8. The immune responses triggered by CpG ODNs in shrimp Litopenaeus vannamei are associated with LvTolls.

    Science.gov (United States)

    Sun, Rui; Wang, Mengqiang; Wang, Lingling; Yue, Feng; Yi, Qilin; Huang, Mengmeng; Liu, Rui; Qiu, Limei; Song, Linsheng

    2014-03-01

    CpG oligodeoxynucleotides (ODNs) represent a kind of pathogen-associated molecular patterns (PAMPs) as well as a novel adjuvant that activate the innate immune system through interaction with Toll-like receptor 9 (TLR9) in mammals. In the present study, the synthetic oligodeoxynucleotides, CpG ODN 2395, was employed to investigate the interactive mode of CpG ODNs with three known Tolls (LvToll1-3) from shrimp Litopenaeus vannamei. The mature peptides of extracellular domains of LvTolls (LvToll-ECDs) were recombinant expressed and their binding activities to CpG ODN 2395 were further examined by ELISA. rLvToll1-ECD and rLvToll3-ECD exhibited affinity to CpG ODN 2395 in a dose-dependent manner when their concentrations ranged from 0.25 to 2.00 μmol/L, while rLvToll2-ECD did not show any binding activities to CpG ODN 2395 in tested concentrations. Additionally, after the stimulation of CpG ODN 2395, the luciferase activities of HEK293T cells transfected with LvToll1-mosaic or LvToll3-mosaic were significantly increased to 2.38-fold (pvannamei were indispensable for the triggering of immune responses by CpG ODNs, and the results provided a foundation for the application of CpG ODNs as the novel immunostimulants in aquaculture.

  9. Comparison of three feline leukaemia virus (FeLV) point-of-care antigen test kits using blood and saliva.

    Science.gov (United States)

    Westman, Mark E; Malik, Richard; Hall, Evelyn; Sheehy, Paul A; Norris, Jacqueline M

    2017-02-01

    Feline leukaemia virus (FeLV) can be a challenging infection to diagnose due to a complex feline host-pathogen relationship and occasionally unreliable test results. This study compared the accuracy of three point-of-care (PoC) FeLV p27 antigen test kits commonly used in Australia and available commercially worldwide (SNAP FIV/FeLV Combo, Witness FeLV/FIV and Anigen Rapid FIV/FeLV), using detection of FeLV provirus by an in-house real-time polymerase chain reaction (qPCR) assay as the diagnostic gold standard. Blood (n=563) and saliva (n=419) specimens were collected from a population of cats determined to include 491 FeLV-uninfected and 72 FeLV-infected individuals (45 progressive infections [p27 and qPCR positive], 27 regressive infections [p27 negative, qPCR positive]). Sensitivity and specificity using whole blood was 63% and 94% for SNAP Combo, 57% and 98% for Witness, and 57% and 98% for Anigen Rapid, respectively. SNAP Combo had a significantly lower specificity using blood compared to the other two kits (P=0.004 compared to Witness, P=0.007 compared to Anigen Rapid). False-positive test results occurred with all three kits using blood, and although using any two kits in parallel increased specificity, no combination of kits completely eliminated the occurrence of false-positive results. We therefore recommend FeLV proviral PCR testing for any cat that tests positive with a PoC FeLV antigen kit, as well as for any cat that has been potentially exposed to FeLV but tests negative with a FeLV antigen kit, before final assignment of FeLV status can be made with confidence. For saliva testing, sensitivity and specificity was 54% and 100%, respectively, for all three test kits. The reduced sensitivity of saliva testing compared to blood testing, although not statistically significant, suggests saliva testing with the current generation of PoC FeLV antigen kits is unsuitable for screening large populations of cats, such as in shelters. Copyright © 2016 Elsevier

  10. Multiplying dimensions

    CERN Multimedia

    2013-01-01

    A few weeks ago, I had a vague notion of what TED was, and how it worked, but now I’m a confirmed fan. It was my privilege to host CERN’s first TEDx event last Friday, and I can honestly say that I can’t remember a time when I was exposed to so much brilliance in such a short time.   TEDxCERN was designed to give a platform to science. That’s why we called it Multiplying Dimensions – a nod towards the work we do here, while pointing to the broader importance of science in society. We had talks ranging from the most subtle pondering on the nature of consciousness to an eighteen year old researcher urging us to be patient, and to learn from our mistakes. We had musical interludes that included encounters between the choirs of local schools and will.i.am, between an Israeli pianist and an Iranian percussionist, and between Grand Opera and high humour. And although I opened the event by announcing it as a day off from physics, we had a quite brill...

  11. Analysis of critical operating conditions for LV distribution networks with microgrids

    Science.gov (United States)

    Zehir, M. A.; Batman, A.; Sonmez, M. A.; Font, A.; Tsiamitros, D.; Stimoniaris, D.; Kollatou, T.; Bagriyanik, M.; Ozdemir, A.; Dialynas, E.

    2016-11-01

    Increase in the penetration of Distributed Generation (DG) in distribution networks, raises the risk of voltage limit violations while contributing to line losses. Especially in low voltage (LV) distribution networks (secondary distribution networks), impacts of active power flows on the bus voltages and on the network losses are more dominant. As network operators must meet regulatory limitations, they have to take into account the most critical operating conditions in their systems. In this study, it is aimed to present the impact of the worst operation cases of LV distribution networks comprising microgrids. Simulation studies are performed on a field data-based virtual test-bed. The simulations are repeated for several cases consisting different microgrid points of connection with different network loading and microgrid supply/demand conditions.

  12. Capability to provide reactive power in PV farms. Implementation of LV capacitors

    Energy Technology Data Exchange (ETDEWEB)

    Gal, Isabelle; NGuyen, Minh Quang [Schneider Electric (France)

    2011-07-01

    The latest French grid code assigns a new role to generators connected to the distribution system: they have to contribute to the grid operation by ancillary services, even though they may use renewable energies. Among others, the likely incapacity of such a generator to provide the requested reactive power during steady state operation or during a fault may impose the use of capacitors. For economical reasons, it could be worth installing LV- instead of HV-capacitors. This paper analyses an example photovoltaic fram to evaluate the risks encountered. Results obtained show that the installation of LV capacitors may be possible if very carefully. Indeed, steady state harmonics generated by the inverter can be amplified, and there may be high overvoltages in the installation after upstream switching off. Further analysis should be done to extend the validity of conclusions, but at this stage, installing HV capacitors should be preferred. (orig.)

  13. Seismic monitoring during acid stimulation of wells LV-4 and LV-13 at the Las Tres Virgenes geothermal field, BCS, Mexico; Monitoreo sismico durante la estimulacion acida de los pozos LV-4 y LV-13 del campo geotermico de Las Tres Virgenes, BCS, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Venegas Salgado, Saul; Arredondo Fragoso, Jesus; Ramirez Silva, German; Flores Armenta, Magaly; Ramirez Montes, Miguel [Comision Federal de Electricidad, Gerencia de Proyectos Geotermoelectricos, Morelia, Michoacan (Mexico)]. E-mail: magaly.flores@cfe.gob.mx

    2006-07-15

    From September through December 2004 a seismic monitoring in the Las Tres Virgenes, BCS, geothermal field was carried out simultaneously with the acid stimulation of wells LV-4 and LV-13. The seismic network had four digital seismographs and recorded 174 local seismic events, 131 regional ones and many more volcanic signals at seismic station TV20 during the acid stimulation. Additionally, 37 seismic events were located, 22 of them inside the most important geothermal zone at depths between 0.4 and 4 km with typically low magnitudes (0.7 to 2.2 Md). Two relevant zones were determined: Zone A related to the El Volcan fault system and Zone B related to injection well LV-8. In Zone A the well-induction stage and the operation start of the wells LV-4 and LV-13 after acidification on October 30 and November 17, 2004, increased seismic activity to a maximum of 12 daily events in early December. When the two wells in Zone B were cooled before the acidification, the seismic events recorded there increased to a maximum of 6 daily events on October 2, and then decreased. Also in Zone B the seismic activity increased after well-induction and the start of well production once they were acidified, recording up to 11 daily events in late November. According to the seismic distribution, we may conclude that the most active fault systems are El Volcan and El Viejo. New proposals for well locations in the field are supported by these results. [Spanish] De septiembre a diciembre de 2004 se realizo un estudio de monitoreo sismico en el campo geotermico de Las Tres Virgenes, BCS, simultaneamente con las estimulaciones acidas de los pozos LV-4 y LV-13. Se utilizo una red sismica conformada por cuatro sismografos digitales, logrando registrar en la estacion sismica TV20 un total de 174 sismos locales, 131 sismos regionales y muchas mas senales de tipo volcanico, durante el periodo del monitoreo de la estimulacion acida. Ademas, se localizaron un total de 37 sismos, de los cuales 22 se

  14. Short-time Lv transform and its application for non-linear FM signal detection

    Institute of Scientific and Technical Information of China (English)

    Shan Luo; Xiumei Li; Guoan Bi

    2015-01-01

    A new time-frequency transform, known as short-time Lv transform (STLVT), is proposed by applying the inverse Lv dis-tribution to process consecutive segments of long data sequence. Compared with other time-frequency representations, the STLVT is able to achieve better energy concentration in the time-frequency domain for signals containing multiple linear and/or non-linear frequency modulated components. The merits of the STLVT are demonstrated in terms of the effects of window length and overlap length between adjacent segments on signal energy concentra-tion in the time-frequency domain, and the required computational complexity. An application on the spectrum sensing for cognitive ratio (CR) by using a joint use of the STLVT and Hough transform (HT) is proposed and simulated.

  15. Voltage regulation in LV grids by coordinated volt-var control strategies

    DEFF Research Database (Denmark)

    Juamperez Goñi, Miguel Angel; Yang, Guangya; Kjær, Søren Bækhøj

    2014-01-01

    in terms of network power losses and voltage level along the feeder. As a practical implementation, a reconfigurable hardware is used for developing a testing platform based on real-time measurements to regulate the reactive power level. The proposed testing platform has been developed within PVNET......The increasing penetration level of photovoltaic (PV) power generation in low voltage (LV) networks results in voltage rise issues, particularly at the end of the feeders. In order to mitigate this problem, several strategies, such as grid reinforcement, transformer tap change, demand......-side management, active power curtailment, and reactive power optimization methods, show their contribution to voltage support, yet still limited. This paper proposes a coordinated volt-var control architecture between the LV distribution transformer and solar inverters to optimize the PV power penetration level...

  16. EV Charging Facilities and Their Application in LV Feeders with Photovoltaics

    DEFF Research Database (Denmark)

    Marra, Francesco; Yang, Guangya; Træholt, Chresten

    2013-01-01

    for the different locations in the feeder. With time-series simulations, we quantify the energy size required for a station ESS. A Belgian LV residential grid, modeled using real PV generation and load profiles, is used as case study. The method and simulation results show the effectiveness of using public EV...... charging facilities with the additional function of voltage regulation in feeders with PV....

  17. Cooling Performance Test of the SCT LV&HV Power Supply Rack

    CERN Document Server

    Böhm, J; Vacek, V

    2005-01-01

    The cooling performance test of the 52U rack, housing SCT LV&HV power supplies for 192 detector modules, being located in USA15 cavern, has been curried out. The rack was equipped with two air-water heat exchangers, air turbine, four vertical fan tray units under crates and horizontal fans in four Artesyn AC/DC power supply units. The resistive dummy loads for 192 power supply channels have been placed in four crates and housed in the adjacent rack.

  18. 重组Lv-SWD蛋白的表达、纯化与细菌结合试验%Expression, Purification and Bacteria Binding Test of a Recombinant Lv-SWD Protein

    Institute of Scientific and Technical Information of China (English)

    杜志强; 林涛

    2014-01-01

    The recombinant Lv-SWD protein of Litopenaeus vannamei function in innate immunity system was researched through protein recombinant expression, polyclonal antibody preparation, and bacteria binding assay. The results showed that the predicted molecular weight of Lv-SWD was 12.9 ku, and the virtual molecular weight was consistent with the predicted value. The polyclonal antibody was prepared by recombinant Lv-SWD protein and could identify the protein antigen. The re-combinant Lv-SWD protein could directly bind to Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, and Vibrio.%通过重组Lv-SWD蛋白的表达与纯化,进行多克隆抗体的制备与细菌结合试验,研究凡纳对虾(Litopenaeus vannamei)重组SWD蛋白在先天免疫系统中的功能。结果表明,Lv-SWD的预测分子质量为12.9 ku,实际大小与理论值相符合。重组Lv-SWD蛋白作为抗原制备的多克隆抗体,可以较好地识别蛋白质本身,且可以直接结合巨大芽孢杆菌(Bacillus subtilis)、金黄色葡萄球菌(Staphylococcus aureus)、绿脓杆菌(Pseudomonas aeruginosa)以及弧菌(Vibrio)4种细菌。

  19. A New Protection System for Islanding Detection in LV Distribution Systems

    Directory of Open Access Journals (Sweden)

    Anna Rita Di Fazio

    2015-04-01

    Full Text Available The growth of penetration of Distributed Generators (DGs is increasing the risk of unwanted islanded operation in Low Voltage (LV distribution systems. In this scenario, the existing anti-islanding protection systems, installed at the DG premises and based on classical voltage and frequency relays, are no longer effective, especially in the cases of islands characterized by a close match between generation and load. In this paper, a new protection system for islanding detection in LV distribution systems is proposed. The classical voltage and frequency relays in the DG interface protections are enriched with an innovative Smart Islanding Detector, which adopts a new passive islanding detection method. The aim is to keep the advantages of the classical relays while overcoming the problem of their limited sensitivity in detecting balanced islands. In the paper, to define the requirements of the anti-islanding protection system, the events causing the islanded operation of the LV distribution systems are firstly identified and classified. Then, referring to proposed protection system, its architecture and operation are described and, eventually, its performance is analyzed and validated by experimental laboratory tests, carried out with a hardware-in-the-loop technique.

  20. On the Interpretation of the l-v Features in the Milky Way Galaxy

    Science.gov (United States)

    Baba, Junichi; Saitoh, Takayuki R.; Wada, Keiichi

    2010-12-01

    We modeled the gas dynamics of barred galaxies using a three-dimensional, high-resolution, N-body + hydrodynamical simulation, and applied it to the Milky Way in an attempt to reproduce both the large-scale structure and the clumpy morphology observed in galactic H I and CO l-v diagrams. Owing to including of the multi-phase interstellar medium, self-gravity, star-formation, and supernovae feedback, the clumpy morphology, as well as the large-scale features, in observed l-v diagrams were naturally reproduced. We identified in our l-v diagrams with a number of not only large-scale peculiar features, such as the `3-kpc arm', `135-km s-1 arm', and `Connecting arm', but also clumpy features, such as `Bania clumps', and then linked these features in a face-on view of our model. We give suggestions on the real structure of the Milky Way and on the fate of gas clumps in the central region.

  1. Quantifying grain shape with MorpheoLV: A case study using Holocene glacial marine sediments

    Science.gov (United States)

    Charpentier, Isabelle; Staszyc, Alicia B.; Wellner, Julia S.; Alejandro, Vanessa

    2017-06-01

    As demonstrated in earlier works, quantitative grain shape analysis has revealed to be a strong proxy for determining sediment transport history and depositional environments. MorpheoLV, devoted to the calculation of roughness coefficients from pictures of unique clastic sediment grains using Fourier analysis, drives computations for a collection of samples of grain images. This process may be applied to sedimentary deposits assuming core/interval/image archives for the storage of samples collected along depth. This study uses a 25.8 m jumbo piston core, NBP1203 JPC36, taken from a 100 m thick sedimentary drift deposit from Perseverance Drift on the northern Antarctic Peninsula continental shelf. Changes in ocean and ice conditions throughout the Holocene recorded in this sedimentary archive can be assessed by studying grain shape, grain texture, and other proxies. Ninety six intervals were sampled and a total of 2319 individual particle images were used. Microtextures of individual grains observed by SEM show a very high abundance of authigenically precipitated silica that obscures the original grain shape. Grain roughness, computed along depth with MorpheoLV, only shows small variation confirming the qualitative observation deduced from the SEM. Despite this, trends can be seen confirming the reliability of MorpheoLV as a tool for quantitative grain shape analysis.

  2. Demand calculations for transformer dimensioning; Calculo de demanda para dimensionamento de transformadores

    Energy Technology Data Exchange (ETDEWEB)

    Villela, Anderson Goncalves; Carvalho, Valdivino Alves de [AES Eletropaulo, SP (Brazil)

    2010-10-15

    The calculation algorithm adopted by the AES Eletropaulo, Brazil, for the dimensioning of LV transformers did not represent the real grid conditions, being necessary the development of a new method. This paper presents the new procedure, based on the application of typical load curves and the consumption of energy calculation based on the load information supplied by clients and designers. (author)

  3. Envelope Proteins of White Spot Syndrome Virus (WSSV Interact with Litopenaeus vannamei Peritrophin-Like Protein (LvPT.

    Directory of Open Access Journals (Sweden)

    Shijun Xie

    Full Text Available White spot syndrome virus (WSSV is a major pathogen in shrimp cultures. The interactions between viral proteins and their receptors on the surface of cells in a frontier target tissue are crucial for triggering an infection. In this study, a yeast two-hybrid (Y2H library was constructed using cDNA obtained from the stomach and gut of Litopenaeus vannamei, to ascertain the role of envelope proteins in WSSV infection. For this purpose, VP37 was used as the bait in the Y2H library screening. Forty positive clones were detected after screening. The positive clones were analyzed and discriminated, and two clones belonging to the peritrophin family were subsequently confirmed as genuine positive clones. Sequence analysis revealed that both clones could be considered as the same gene, LV-peritrophin (LvPT. Co-immunoprecipitation confirmed the interaction between LvPT and VP37. Further studies in the Y2H system revealed that LvPT could also interact with other WSSV envelope proteins such as VP32, VP38A, VP39B, and VP41A. The distribution of LvPT in tissues revealed that LvPT was mainly expressed in the stomach than in other tissues. In addition, LvPT was found to be a secretory protein, and its chitin-binding ability was also confirmed.

  4. Envelope Proteins of White Spot Syndrome Virus (WSSV) Interact with Litopenaeus vannamei Peritrophin-Like Protein (LvPT).

    Science.gov (United States)

    Xie, Shijun; Zhang, Xiaojun; Zhang, Jiquan; Li, Fuhua; Xiang, Jianhai

    2015-01-01

    White spot syndrome virus (WSSV) is a major pathogen in shrimp cultures. The interactions between viral proteins and their receptors on the surface of cells in a frontier target tissue are crucial for triggering an infection. In this study, a yeast two-hybrid (Y2H) library was constructed using cDNA obtained from the stomach and gut of Litopenaeus vannamei, to ascertain the role of envelope proteins in WSSV infection. For this purpose, VP37 was used as the bait in the Y2H library screening. Forty positive clones were detected after screening. The positive clones were analyzed and discriminated, and two clones belonging to the peritrophin family were subsequently confirmed as genuine positive clones. Sequence analysis revealed that both clones could be considered as the same gene, LV-peritrophin (LvPT). Co-immunoprecipitation confirmed the interaction between LvPT and VP37. Further studies in the Y2H system revealed that LvPT could also interact with other WSSV envelope proteins such as VP32, VP38A, VP39B, and VP41A. The distribution of LvPT in tissues revealed that LvPT was mainly expressed in the stomach than in other tissues. In addition, LvPT was found to be a secretory protein, and its chitin-binding ability was also confirmed.

  5. Parámetros inmunitaríos en camarones juveniles lv en piscinas camaroneras infectadas con white spot syndrom virus

    OpenAIRE

    Montesdeoca, Bélgica Mercedes; Ibarra, Eulalia; Rodríguez, Jenny

    2002-01-01

    Parámetros inmunitarios en camarones juveniles LV en piscinas camaroneras infectadas con White Spot Syndrom Virus Parámetros inmunitarios en camarones juveniles LV en piscinas camaroneras infectadas con White Spot Syndrom Virus

  6. Global end-diastolic volume increases to maintain fluid responsiveness in sepsis-induced systolic dysfunction

    NARCIS (Netherlands)

    R.J. Trof (R.); I. Danad (Ibrahim); A.B.J. Groeneveld (Johan)

    2013-01-01

    textabstractBackground: Sepsis-induced cardiac dysfunction may limit fluid responsiveness and the mechanism thereof remains unclear. Since cardiac function may affect the relative value of cardiac filling pressures, such as the recommended central venous pressure (CVP), versus filling volumes in gui

  7. Left Ventricle: Fully Automated Segmentation Based on Spatiotemporal Continuity and Myocardium Information in Cine Cardiac Magnetic Resonance Imaging (LV-FAST

    Directory of Open Access Journals (Sweden)

    Lijia Wang

    2015-01-01

    Full Text Available CMR quantification of LV chamber volumes typically and manually defines the basal-most LV, which adds processing time and user-dependence. This study developed an LV segmentation method that is fully automated based on the spatiotemporal continuity of the LV (LV-FAST. An iteratively decreasing threshold region growing approach was used first from the midventricle to the apex, until the LV area and shape discontinued, and then from midventricle to the base, until less than 50% of the myocardium circumference was observable. Region growth was constrained by LV spatiotemporal continuity to improve robustness of apical and basal segmentations. The LV-FAST method was compared with manual tracing on cardiac cine MRI data of 45 consecutive patients. Of the 45 patients, LV-FAST and manual selection identified the same apical slices at both ED and ES and the same basal slices at both ED and ES in 38, 38, 38, and 41 cases, respectively, and their measurements agreed within -1.6±8.7 mL, -1.4±7.8 mL, and 1.0±5.8% for EDV, ESV, and EF, respectively. LV-FAST allowed LV volume-time course quantitatively measured within 3 seconds on a standard desktop computer, which is fast and accurate for processing the cine volumetric cardiac MRI data, and enables LV filling course quantification over the cardiac cycle.

  8. Quantifying coronary sinus flow and global LV perfusion at 3T

    Directory of Open Access Journals (Sweden)

    Bloch Karin

    2009-06-01

    Full Text Available Abstract Background Despite the large availability of 3T MR scanners and the potential of high field imaging, this technical platform has yet to prove its usefulness in the cardiac MR setting, where 1.5T remains the established standard. Global perfusion of the left ventricle, as well as the coronary flow reserve (CFR, can provide relevant diagnostic information, and MR measurements of these parameters may benefit from increased field strength. Quantitative flow measurements in the coronary sinus (CS provide one method to investigate these parameters. However, the ability of newly developed faster MR sequences to measure coronary flow during a breath-hold at 3T has not been evaluated. Methods The aim of this work was to measure CS flow using segmented phase contrast MR (PC MR on a clinical 3T MR scanner. Parallel imaging was employed to reduce the total acquisition time. Global LV perfusion was calculated by dividing CS flow with left ventricular (LV mass. The repeatability of the method was investigated by measuring the flow three times in each of the twelve volunteers. Phantom experiments were performed to investigate potential error sources. Results The average CS flow was determined to 88 ± 33 ml/min and the deduced LV perfusion was 0.60 ± 0.22 ml/min·g, in agreement with published values. The repeatability (1-error of the three repeated measurements in each subject was on average 84%. Conclusion This work demonstrates that the combination of high field strength (3T, parallel imaging and segmented gradient echo sequences allow for quantification of the CS flow and global perfusion within a breath-hold.

  9. Reduction of low voltage power cables electromagnetic field emission in MV/LV substations

    Energy Technology Data Exchange (ETDEWEB)

    Beltran San Segundo, Hector [Dpt. Industrial Systems Engineering and Design, Campus del Riu Sec, Universitat Jaume I, 12071 Castello (Spain); Fuster Roig, Vicente [Instituto de Tecnologia Electrica, Avda. Juan de la Cierva 24, Parc Tecnologic de Valencia, 46980 Paterna (Spain)

    2008-06-15

    In this paper a solution to reduce magnetic field emission levels generated by MV/LV substation power cables is proposed. The reduction is obtained by the arrangement of the phases in a proper way and by shielding the cables with magnetic or conductive materials. The effects introduced by these two options have been analyzed by means of simulations, using finite elements method calculation software, and by experimental measurements. The introduced results allow selecting an optimal arrangement and the best screening material in order to reduce the magnetic fields in those directions required to protect. (author)

  10. Clustered PV Inverters in LV Networks: An Overview of Impacts and Comparison of Voltage Control Strategies

    DEFF Research Database (Denmark)

    Demirok, Erhan; Sera, Dezso; Teodorescu, Remus;

    2009-01-01

    and power quality must be maintained or improved by adding cooperative control features to the grid-connected inverters. This paper first gives an overview of bilateral impacts between multiple distributed generations (DG) and grid. Regarding of these impacts, recent advances in static grid voltage support......High penetration of photovoltaic (PV) inverters in low voltage (LV) distribution network challenges the voltage stability due to interaction between multiple inverters and grid. As the main objective is to provide more power injection from VSC-based PV inverters, grid stability, reliability...

  11. Power flow analysis for droop controlled LV hybrid AC-DC microgrids with virtual impedance

    DEFF Research Database (Denmark)

    Li, Chendan; Chaudhary, Sanjay; Vasquez, Juan Carlos

    2014-01-01

    The AC-DC hybrid microgrid is an effective form of utilizing different energy resources and the analysis of this system requires a proper power flow algorithm. This paper proposes a suitable power flow algorithm for LV hybrid AC-DC microgrid based on droop control and virtual impedance. Droop...... and virtual impedance concepts for AC network, DC network and interlinking converter are reviewed so as to model it in the power flow analysis. The validation of the algorithm is verified by comparing it with steady state results from detailed time domain simulation. The effectiveness of the proposed...

  12. An efficient method for accurate segmentation of LV in contrast-enhanced cardiac MR images

    Science.gov (United States)

    Suryanarayana K., Venkata; Mitra, Abhishek; Srikrishnan, V.; Jo, Hyun Hee; Bidesi, Anup

    2016-03-01

    Segmentation of left ventricle (LV) in contrast-enhanced cardiac MR images is a challenging task because of high variability in the image intensity. This is due to a) wash-in and wash-out of the contrast agent over time and b) poor contrast around the epicardium (outer wall) region. Current approaches for segmentation of the endocardium (inner wall) usually involve application of a threshold within the region of interest, followed by refinement techniques like active contours. A limitation of this method is under-segmentation of the inner wall because of gradual loss of contrast at the wall boundary. On the other hand, the challenge in outer wall segmentation is the lack of reliable boundaries because of poor contrast. There are four main contributions in this paper to address the aforementioned issues. First, a seed image is selected using variance based approach on 4D time-frame images over which initial endocardium and epicardium is segmented. Secondly, we propose a patch based feature which overcomes the problem of gradual contrast loss for LV endocardium segmentation. Third, we propose a novel Iterative-Edge-Refinement (IER) technique for epicardium segmentation. Fourth, we propose a greedy search algorithm for propagating the initial contour segmented on seed-image across other time frame images. We have experimented our technique on five contrast-enhanced cardiac MR Datasets (4D) having a total of 1097 images. The segmentation results for all 1097 images have been visually inspected by a clinical expert and have shown good accuracy.

  13. ATP synthase subunit alpha and LV mass in ischaemic human hearts.

    Science.gov (United States)

    Roselló-Lletí, Esther; Tarazón, Estefanía; Barderas, María G; Ortega, Ana; Molina-Navarro, Maria Micaela; Martínez, Alba; Lago, Francisca; Martínez-Dolz, Luis; González-Juanatey, Jose Ramón; Salvador, Antonio; Portolés, Manuel; Rivera, Miguel

    2015-02-01

    Mitochondrial dysfunction plays a critical role in the development of ischaemic cardiomyopathy (ICM). In this study, the mitochondrial proteome in the cardiac tissue of ICM patients was analysed by quantitative differential electrophoresis (2D-DIGE) and mass spectrometry (MS) for the first time to provide new insights into cardiac dysfunction in this cardiomyopathy. We isolated mitochondria from LV samples of explanted hearts of ICM patients (n = 8) and control donors (n = 8) and used a proteomic approach to investigate the variations in mitochondrial protein expression. We found that most of the altered proteins were involved in cardiac energy metabolism (82%). We focused on ATPA, which is involved in energy production, and dihydrolipoyl dehydrogenase, implicated in substrate utilization, and observed that these molecules were overexpressed and that the changes detected in the processes mediated by these proteins were closely related. Notably, we found that ATPA overexpression was associated with reduction in LV mass (r = -0.74, P ATPA could serve as a molecular target suitable for new therapeutic interventions.

  14. Solution to avoid unwanted trips for PV systems connected to LV network facing voltage sags

    Energy Technology Data Exchange (ETDEWEB)

    Le Thi Minh, Chau; Tran-Quoc, Tuan; Kieny, Christophe [IDEA, Saint-Martin-d' Heres (France); Bacha, Seddik [Grenoble Electric Engineering Laboratory, Saint-Martin-d' Heres (France); Cabanac, Philippe; Grenard, Sebastien [Electricite de France, Clamart (France). Direction des Etudes et Recherches; Goulielmakis, David [Schneider Electric, Grenoble (France). Projects and Engineering Center

    2011-07-01

    Most of photovoltaic (PV) systems connected to low voltage (LV) distribution networks have a single-phase connection. The analysis of the behavior of these single-phase connection. The analysis of the behavior of these single-phase PV inverters facing voltage sags caused by short circuits is of major concern. These behaviors depend on fault types, fault location, types of grid architecture, grid protection systems (with or without auto-recloser system) and PV protection types. Therefore, the first investigation of this work is to study comprehensively the behaviors of PV systems connected to real LV networks facing voltage sags in different scenarios by taking into account the real network protection. Furthermore, future power systems with a large share of PV systems connected could be severely affected if several of the PV systems are tripping at the same instant. From these results of simulation, unwanted trip cases, due to the disconnection protection of PV systems are identified. Finally, a simple efficient solution by using the voltage-time characteristic for PV system is proposed. The validation by simulations shows the efficiency of the proposed solution. (orig.)

  15. Classification of LV wall motion in cardiac MRI using kernel Dictionary Learning with a parametric approach.

    Science.gov (United States)

    Mantilla, Juan; Paredes, Jose; Bellanger, Jean-J; Donal, Erwan; Leclercq, Christophe; Medina, Ruben; Garreau, Mireille

    2015-01-01

    In this paper, we propose a parametric approach for the assessment of wall motion in Left Ventricle (LV) function in cardiac cine-Magnetic Resonance Imaging (MRI). Time-signal intensity curves (TSICs) are identified in Spatio-temporal image profiles extracted from different anatomical segments in a cardiac MRI sequence. Different parameters are constructed from specific TSICs that present a decreasing then increasing shape reflecting dynamic information of the LV contraction. The parameters extracted from these curves are related to: 1) an average curve based on a clustering process, 2) curve skewness and 3) cross correlation values between each average clustered curve and a patient-specific reference. Several tests are performed in order to construct different vectors to train a sparse classifier based on kernel Dictionary Learning (DL). Results are compared with other classifiers like Support Vector Machine (SVM) and Discriminative Dictionary Learning. The best classification performance is obtained with information of skewness and the average curve with an accuracy about 94% using the mentioned sparse based kernel DL with a radial basis function kernel.

  16. Effects of interleukin-1 blockade with anakinra on adverse cardiac remodeling and heart failure after acute myocardial infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) pilot study].

    Science.gov (United States)

    Abbate, Antonio; Van Tassell, Benjamin Wallace; Biondi-Zoccai, Giuseppe; Kontos, Michael Christopher; Grizzard, John Dallas; Spillman, Debra Whittaker; Oddi, Claudia; Roberts, Charlotte Susan; Melchior, Ryan David; Mueller, George Herman; Abouzaki, Nayef Antar; Rengel, Lenore Rosemary; Varma, Amit; Gambill, Michael Lucas; Falcao, Raquel Appa; Voelkel, Norbert Felix; Dinarello, Charles Anthony; Vetrovec, George Wayne

    2013-05-15

    effect on LV end-systolic volume index, LV end-diastolic volume index, or LV ejection fraction in this cohort of clinically stable patients with near-normal LV dimensions and function, anakinra led to a numerically lower incidence of heart failure. Copyright © 2013 Elsevier Inc. All rights reserved.

  17. Systolic Longitudinal Function of the Left Ventricle Assessed by Speckle Tracking in Heart Failure Patients with Preserved Ejection Fraction

    Directory of Open Access Journals (Sweden)

    Mehrnoush Toufan

    2016-03-01

    Full Text Available Background: Echocardiographic evaluations of the longitudinal axis of the left ventricular (LV function have been used in the diagnosis and assessment of heart failure with normal ejection fraction (HFNEF. The evaluation of the global and segmental peak systolic longitudinal strains (PSLSs by two-dimensional speckle tracking echocardiography (STE may correlate with conventional echocardiography findings. We aimed to use STE to evaluate the longitudinal function of the LV in patients with HFNEF.Methods: In this study, 126 patients with HFNEF and diastolic dysfunction and 60 normal subjects on conventional echocardiography underwent STE evaluations, including LV end-diastolic and end-systolic dimensions; interventricular septal thickness; posterior wall thickness;  LV volume; LV ejection fraction; left atrial volume index; early diastolic peak flow velocity (

  18. Current status of the Citrus leprosis virus (CiLV -C and its vector Brevipalpus phoenicis (Geijskes

    Directory of Open Access Journals (Sweden)

    Guillermo León M

    2012-08-01

    Full Text Available The Citrus leprosis virus CiLV-C is a quarantine disease of economic importance. Over the past 15 years, this disease has spread to several countries of Central and South America. Colombia has about 45,000 hectares of citrus planted with an annual production of 750,000 tonnes. The CiLV-C has only been detected in the departments of Meta, Casanare and recently Tolima. Meta has 4,300 hectares representing 10% of the national cultivated area, and Casanare, where CiLV-C appeared in 2004, has no more than 500 ha planted with citrus. The presence of the Citrus leprosis virus in Colombia could affect the international market for citrus, other crops and ornamental plants with the United States and other countries without the disease. The false spider mite Brevipalpus phoenicis (Geijskes (Acari: Tenuipalpidae is the main vector of the CiLV-C. Disease management is based on control programs of the vector and diminishing host plants. Chemical mite control is expensive, wasteful and generates resistance to different acaricides. This paper provides basic information on CiLV-C and its vector, advances in diagnosis and methods to control the disease and prevention of its spread

  19. 一种新的LV-BPL宽带通信系统仿真%Simulation of Digital Fountain Concatenated Coding Wavelet-Packet-Based Broadband System in LV-BPL

    Institute of Scientific and Technical Information of China (English)

    杨航; 茹乐; 杜兴民; 唐红

    2007-01-01

    室内低压电力线(LV-BPL)通信是一种新的宽带接入技术,基于数字喷泉码与正交小波包调制提出了一种新的LV-BPL编码多载波调制通信系统模型.系统采用Raptor码作外码,块编码作内码,按块编码调制(BCM)映射到正交小波包调制时频平面.由于小波包稳定的正交性、自由的时频铺砌,数字喷泉码与码率无关的性质及BCM抗脉冲干扰的特点,系统在LV-BPL信道具有比编码DFT-OFDM更好的性能.

  20. Extinction in SC galaxies - an analysis of the ESO-LV data

    Science.gov (United States)

    Huizinga, J. E.; van Albada, T. S.

    1992-02-01

    The surface photometry of Sc galaxies in the ESO-LV database in view of recent claims by Valentijn that spiral galaxies are opaque over their entire disks is analyzed. Using diameter-limited and magnitude-limited subsamples, it can discriminate between the opaque and transparent cases with the axis-ratio distribution test. Results support the traditional view that Sc galaxies are semitransparent, but the brightness difference between face-on and edge-on can be as large as 1.0 to 1.5 mag. Analyzing surface-brightness profiles at various radii, it is seen that the central regions are essentially opaque, and the outer regions nearly fully transparent. It is shown that conclusions differ from those of Valentijn, because of neglect to take secondary inclination effects into account.

  1. Efficient Control of Energy Storage for Increasing the PV Hosting Capacity of LV Grids

    DEFF Research Database (Denmark)

    Hashemi Toghroljerdi, Seyedmostafa; Østergaard, Jacob

    2016-01-01

    hosting capacity of LV grids by determining dynamic set points for EESS management. The method has the effectiveness of central control methods and can effectively decrease the energy storage required for overvoltage prevention, yet it eliminates the need for a broadband and fast communication. The net...... power injected into the grid and the amount of reactive power absorbed by PV inverters are estimated using the PV generation forecast and load consumption forecast, and the dynamic operating points for energy storage management are determined for a specific period of time by solving a linear...... grid is usually limited by overvoltage, and the efficient control of distributed electrical energy storage systems (EESSs) can considerably increase this capacity. In this paper, a new control approach based on the voltage sensitivity analysis is proposed to prevent overvoltage and increase the PV...

  2. Estimation of Maximum Allowable PV Connection to LV Residential Power Networks

    DEFF Research Database (Denmark)

    Demirok, Erhan; Sera, Dezso; Teodorescu, Remus

    2011-01-01

    transformer or using solar inverters with new grid support features. This study presents a methodology for the estimation of maximum PV hosting capacity including IEC 60076-7 based thermal model of distribution transformer. Certain part of a real distribution network of Braedstrup suburban area in Denmark...... is used in simulation as a case study model. Furthermore, varying solutions (utilizing thermally upgraded insulation paper in transformers, reactive power services from solar inverters, etc.) are implemented on the network under investigation to examine PV penetration level and finally key results learnt......Maximum photovoltaic (PV) hosting capacity of low voltage (LV) power networks is mainly restricted by either thermal limits of network components or grid voltage quality resulted from high penetration of distributed PV systems. This maximum hosting capacity may be lower than the available solar...

  3. Curva de rotação óptica de ESO-LV 5100550

    Science.gov (United States)

    Carvalho, D. B.; Soares, D. S. L.

    2003-08-01

    ESO-LV 5100550 é o membro mais fraco do par de galáxias austral SBG 357 (Soares et al. 1995). É classificada no catálogo RC3 como uma espiral ordinária de tipo inicial (early-type); porém, uma análise morfológica sugere que ela tenha uma grande barra. O objetivo do estudo é determinar sua cinemática de tal modo que possamos inferir mais a respeito de sua dinâmica, provavelmente perturbada, já que se espera que esteja sob forte influência da companheira ESO-LV 5100560. Apresentarei resultados parciais determinados a partir de espectros obtidos com o instrumento Double Spectrograph montado no telescópio Hale do Monte Palomar, EUA. As observações foram realizadas por D.S.L. Soares, P.M.V. Veiga e T.E. Nordgren, em 1998. Foram tomados espectros de fenda longa posicionada sobre a linha dos nodos do disco e ao longo da suposta barra. Os dados foram reduzidos com uso do pacote IRAF. Obtivemos o perfil de velocidades radiais na linha de visada ao longo das fendas e calculamos o desvio para o vermelho cosmológico do sistema, com base no espectro central. Determinamos as curvas de rotação deprojetadas, com base em cálculos para os valores teóricos esperados das componentes de velocidades puramente circulares em um disco inclinado. A inclinação do disco, dado fundamental nesta deprojeção, foi estimada através da média das elipticidades das isofotas mais externas.

  4. Impact of Distributed Generation Grid Code Requirements on Islanding Detection in LV Networks

    Directory of Open Access Journals (Sweden)

    Fabio Bignucolo

    2017-01-01

    Full Text Available The recent growing diffusion of dispersed generation in low voltage (LV distribution networks is entailing new rules to make local generators participate in network stability. Consequently, national and international grid codes, which define the connection rules for stability and safety of electrical power systems, have been updated requiring distributed generators and electrical storage systems to supply stabilizing contributions. In this scenario, specific attention to the uncontrolled islanding issue has to be addressed since currently required anti-islanding protection systems, based on relays locally measuring voltage and frequency, could no longer be suitable. In this paper, the effects on the interface protection performance of different LV generators’ stabilizing functions are analysed. The study takes into account existing requirements, such as the generators’ active power regulation (according to the measured frequency and reactive power regulation (depending on the local measured voltage. In addition, the paper focuses on other stabilizing features under discussion, derived from the medium voltage (MV distribution network grid codes or proposed in the literature, such as fast voltage support (FVS and inertia emulation. Stabilizing functions have been reproduced in the DIgSILENT PowerFactory 2016 software environment, making use of its native programming language. Later, they are tested both alone and together, aiming to obtain a comprehensive analysis on their impact on the anti-islanding protection effectiveness. Through dynamic simulations in several network scenarios the paper demonstrates the detrimental impact that such stabilizing regulations may have on loss-of-main protection effectiveness, leading to an increased risk of unintentional islanding.

  5. Decoupled external forces in a predictor-corrector segmentation scheme for LV contours in Tagged MR images.

    Science.gov (United States)

    Garcia-Barnes, Jaume; Andaluz, Albert; Carreras, Francesc; Gil, Debora

    2010-01-01

    Computation of functional regional scores requires proper identification of LV contours. On one hand, manual segmentation is robust, but it is time consuming and requires high expertise. On the other hand, the tag pattern in TMR sequences is a problem for automatic segmentation of LV boundaries. We propose a segmentation method based on a predictor-corrector (Active Contours - Shape Models) scheme. Special stress is put in the definition of the AC external forces. First, we introduce a semantic description of the LV that discriminates myocardial tissue by using texture and motion descriptors. Second, in order to ensure convergence regardless of the initial contour, the external energy is decoupled according to the orientation of the edges in the image potential. We have validated the model in terms of error in segmented contours and accuracy of regional clinical scores.

  6. On Universal Quantum Dimensions

    CERN Document Server

    Mkrtchyan, R L

    2016-01-01

    We derive universal expressions for quantum dimensions (universal characters) of some series of irreps of simple Lie algebras. This allows us to check Deligne's hypothesis on universal quantum dimensions for symmetric cube of adjoint representation.

  7. Surgery for left ventricular aneurysm after myocardial infarction:techniques selection and results assessment

    Institute of Scientific and Technical Information of China (English)

    CHEN Xin; QIU Zhi-bing; XU Ming; LIU Le-le; JIANG Ying-shuo; WANG Li-ming

    2012-01-01

    Background The most appropriate surgical approach for patients with post-infarction left ventricular (LV) aneurysm remains undetermined.We compared the efficacy of the linear versus patch repair techniques,and investigated the mid-term changes of LV geometry and cardiac function,for repair of LV aneurysms.Methods We reviewed the records of 194 patients who had surgery for a post-infarction LV aneurysm between 1998 and 2010.Short-term and mid-term outcomes,including complications,cardiac function and mortality,were assessed.LV end-diastolic and systolic dimensions (LVEDD and LVESD),LV end-diastolic and end-systolic volume indexes (LVEDVI and LVESVI) and LV ejection fraction (LVEF) were measured on pre-operative and follow-up echocardiography.Results Overall in-hospital mortality was 4.12%,and major morbidity showed no significant differences between the two groups.Multivariate analysis identified preoperative left ventricular end diastolic pressure >20 mmHg,low cardiac output and aortic clamping time >2 hours as risk factors for early mortality.Follow-up revealed that LVEF improved from 37% pre-operation to 45% 12 months post-operation in the patch group (P=0.008),and from 44% pre-operation to 40% 12 months postoperation in the linear group (P=0.032).In contrast,the LVEDVI and LVESVI in the linear group were significantly reduced immediately after the operation,and increased again at follow-up.However,in the patch group,the LVEDVI and LVESVI were significantly reduced at follow-up.And there were significant differences in the correct value changes of LVEF and left ventricular remodeling between linear repair and patch groups.Conclusions Persistent reduction of LV dimensions after the patch repair procedure seems to be a procedure-related problem.The choice of the technique should be tailored on an individual basis and surgeon's preference.The patch remodeling technique results in a better LVEF improvement,further significant reductions in LV dimensions

  8. DIFFERENT DIMENSIONS OF TEAMS

    OpenAIRE

    Goparaju Purna SUDHAKAR

    2014-01-01

    Popularity of teams is growing in 21st Century. Organizations are getting their work done through different types of teams. Teams have proved that the collective performance is more than the sum of the individual performances. Thus, the teams have got different dimensions such as quantitative dimensions and qualitative dimensions. The Quantitative dimensions of teams such as team performance, team productivity, team innovation, team effectiveness, team efficiency, team decision making and tea...

  9. DIFFERENT DIMENSIONS OF TEAMS

    OpenAIRE

    Sudhakar, Goparaju Purna

    2013-01-01

    Popularity of teams is growing in 21st Century. Organizations are getting their work done through different types of teams. Teams have proved that the collective performance is more than the sum of the individual performances. Thus, the teams have got different dimensions such as quantitative dimensions and qualitative dimensions. The Quantitative dimensions of teams such as team performance, team productivity, team innovation, team effectiveness, team efficiency, team decision making and tea...

  10. Strongly Gorenstein Flat Dimensions

    Institute of Scientific and Technical Information of China (English)

    Chun Xia ZHANG; Li Min WANG

    2011-01-01

    This article is concerned with the strongly Gorenstein flat dimensions of modules and rings.We show this dimension has nice properties when the ring is coherent,and extend the well-known Hilbert's syzygy theorem to the strongly Gorenstein flat dimensions of rings.Also,we investigate the strongly Gorenstein flat dimensions of direct products of rings and (almost)excellent extensions of rings.

  11. Remediation of Anomia in lvPPA and svPPA

    Directory of Open Access Journals (Sweden)

    Aaron Meyer

    2015-04-01

    Full Text Available Anomia treatment efficacy has been examined in cases with different subtypes of primary progressive aphasia (PPA, and it has been evaluated in groups of participants with the semantic variant (svPPA, but efficacy has not been examined in groups with different subtypes of PPA. Method Participants. Four individuals with the logopenic variant (lvPPA and four individuals with svPPA participated. Procedure. At baseline, participants attempted to name two sets of pictured nouns. One set (Exemplar 1 was utilized during treatment. The second set (Exemplar 2 was never trained and was used to assess stimulus generalization. For each participant, nouns that were consistently named incorrectly were divided among three conditions: Orthographic treatment (OTC, Phonological treatment (PTC, and Untrained (UC. The nouns were matched across conditions for frequency, semantic category, and number of syllables, phonemes, and letters. In the OTC, participants viewed a picture and the corresponding word, read the word out loud, and transcribed the word. In the PTC, participants viewed the picture and a string of symbols. The auditory word was then presented, and participants repeated it. There were two treatment sessions per week during the first month. During the subsequent five months, subjects participated in monthly treatment sessions, in addition to thrice-weekly practice sessions. A post-treatment evaluation began one month after treatment ended. Results lvPPA. From baseline to post-treatment, there was a significant or marginally significant increase in naming accuracy for both exemplars, within every condition [Exemplar 1: UC: t(3 = 2.78, p = .07; PTC: t(3 = 5.75, p = .01; OTC: t(3 = 3.62, p = .04; Exemplar 2: UC: t(3 = 7.82, p = .004; PTC: t(3 = 3.59, p = .04; OTC: t(3 = 3.78, p = .03]. Compared to UC, accuracy at post-treatment was marginally greater for Exemplar 1 in the PTC, t(3 = 3.03, p = .06. There were no other significant or marginally significant

  12. Influence of slice thickness on the determination of left ventricular wall thickness and dimension by magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Ohnishi, Shusaku; Fukui, Sugao; Atsumi, Chisato and others

    1989-02-01

    Wall thickness of the ventricular septum and left ventricle, and left ventricular cavity dimension were determined on magnetic resonance (MR) images with slices 5 mm and 10 mm in thickness. Subjects were 3 healthy volunteers and 7 patients with hypertension (4), hypertrophic cardiomyopathy (one) or valvular heart disease (2). In visualizing the cardiac structures such as left ventricular papillary muscle and right and left ventricles, 5 mm-thick images were better than 10 mm-thick images. Edges of ventricular septum and left ventricular wall were more clearly visualized on 5 mm-thick images than 10 mm-thick images. Two mm-thick MR images obtained from 2 patients yielded the most excellent visualization in end-systole, but failed to reveal cardiac structures in detail in end-diastole. Phantom studies revealed no significant differences in image quality of 10 mm and 5 mm in thickness in the axial view 80 degree to the long axis. In the axial view 45 degree to the long axis, 10 mm-thick images were inferior to 5 mm-thick images in detecting the edge of the septum and the left ventricular wall. These results indicate that the selection of slice thickness is one of the most important determinant factors in the measurement of left ventricular wall thickness and cavity dimension. (Namekawa, K).

  13. LV305, a dendritic cell-targeting integration-deficient ZVex(TM)-based lentiviral vector encoding NY-ESO-1, induces potent anti-tumor immune response.

    Science.gov (United States)

    Albershardt, Tina Chang; Campbell, David James; Parsons, Andrea Jean; Slough, Megan Merrill; Ter Meulen, Jan; Berglund, Peter

    2016-01-01

    We have engineered an integration-deficient lentiviral vector, LV305, to deliver the tumor antigen NY-ESO-1 to human dendritic cells in vivo through pseudotyping with a modified Sindbis virus envelop protein. Mice immunized once with LV305 developed strong, dose-dependent, multifunctional, and cytotoxic NY-ESO-1-specific cluster of differentiation 8 (CD8) T cells within 14 days post-immunization and could be boosted with LV305 at least twice to recall peak-level CD8 T-cell responses. Immunization with LV305 protected mice against tumor growth in an NY-ESO-1-expressing CT26 lung metastasis model, with the protective effect abrogated upon depletion of CD8 T cells. Adoptive transfer of CD8 T cells, alone or together with CD4 T cells or natural killer cells, from LV305-immunized donor mice to tumor-bearing recipient mice conferred significant protection against metastatic tumor growth. Biodistribution of injected LV305 in mice was limited to the site of injection and the draining lymph node, and injected LV305 exhibited minimal excretion. Mice injected with LV305 developed little to no adverse effects, as evaluated by toxicology studies adherent to good laboratory practices. Taken together, these data support the development of LV305 as a clinical candidate for treatment against tumors expressing NY-ESO-1.

  14. Weltkulturerbe Konstantinbasilika Trier. Wandmalerei in freier Bewitterung als konservatorische Herausforderung (ICOMOS Hefte des Deutschen Nationalkomitees LV), hg. v. Nicole Riedl, Berlin 2013

    OpenAIRE

    Wedekind, Wanja

    2013-01-01

    Weltkulturerbe Konstantinbasilika Trier. Wandmalerei in freier Bewitterung als konservatorische Herausforderung (ICOMOS Hefte des Deutschen Nationalkomitees LV, hg. v. Nicole Riedl, Berlin 2013, rezensiert von Wanja Wedekind

  15. Difficulties in demonstrating long term immunity in FeLV vaccinated cats due to increasing age-related resistance to infection

    Directory of Open Access Journals (Sweden)

    Wilson Stephen

    2012-07-01

    Full Text Available Abstract Background Feline leukaemia virus (FeLV is a pathogen causing fatal illness in cats worldwide, and as such there is a high demand for products to protect against disease. The duration of immunity provided by an inactivated FeLV vaccine, Versifel FeLV, when administered to cats of the target age was determined. Kittens received two vaccinations when aged 7 to 9 weeks old, and were subsequently challenged up to 36 months later with the FeLV-A Glasgow isolate. Results In all studies, all of the younger aged control kittens showed persistent FeLV p27 antigenaemia confirming that the challenge virus was severe and efficacious. In contrast, the control cats did not show the required level of persistent antigenaemia, with a maximum of 45% cats affected in the middle duration study and only 10% in the longer study. However, apart from one animal in the short duration study, all of the cats vaccinated with Versifel FeLV were negative for persistent antigenaemia and can be considered treatment successes. Conclusion In conclusion, we have shown that although age-related resistance to infection with a virulent FeLV challenge is evident from as early as 10 months of age, vaccination with Versifel FeLV may aid in the protection of cats from FeLV related disease up to three years after primary vaccination as kittens.

  16. Molecular characterization of LvAV in response to white spot syndrome virus infection in the Pacific white shrimp (Litopenaeus vannamei).

    Science.gov (United States)

    He, Shulin; Song, Lei; Qian, Zhaoying; Hou, Fujun; Liu, Yongjie; Wang, Xianzong; Peng, Zhangming; Sun, Chengbo; Liu, Xiaolin

    2015-07-01

    Litopenaeus vannamei is the most important farmed shrimp species globally, but its production is affected by several factors, including infectious disease. White spot syndrome virus (WSSV), in particular, causes significant shrimp losses. To understand the shrimp's immune response against WSSV, we cloned LvAV from L. vannamei and analyzed its expression pattern in different tissues, in addition to its expression following infection. We employed dsRNA and recombinant (r)LvAV to explore the potential role of LvAV in shrimp immunity when infected with WSSV. We find that LvAV is a C-type Lectin composed of 176 amino acids with a signal peptide and a specific C-type Lectin-type domain (CTLD). It shares 81% amino acid similarity with PmAV, an antiviral-like C-type Lectin from Penaeus monodom, and it is highly expressed in the hepatopancreas. Its expression is affected by infection with both WSSV and V. parahaemolyticus. Significantly, injection with rLvAV slowed WSSV replication, while injection with LvAV dsRNA initially led to enhanced virus propagation. Surprisingly, LvAV dsRNA subsequently led to a dramatic decrease in viral load in the later stages of infection, suggesting that LvAV may be subverted by WSSV to enhance viral replication or immune avoidance. Our results indicate that LvAV plays an important, but potentially complex role in the Pacific white shrimp's immune defense.

  17. LV305, a dendritic cell-targeting integration-deficient ZVexTM-based lentiviral vector encoding NY-ESO-1, induces potent anti-tumor immune response

    Science.gov (United States)

    Albershardt, Tina Chang; Campbell, David James; Parsons, Andrea Jean; Slough, Megan Merrill; ter Meulen, Jan; Berglund, Peter

    2016-01-01

    We have engineered an integration-deficient lentiviral vector, LV305, to deliver the tumor antigen NY-ESO-1 to human dendritic cells in vivo through pseudotyping with a modified Sindbis virus envelop protein. Mice immunized once with LV305 developed strong, dose-dependent, multifunctional, and cytotoxic NY-ESO-1-specific cluster of differentiation 8 (CD8) T cells within 14 days post-immunization and could be boosted with LV305 at least twice to recall peak-level CD8 T-cell responses. Immunization with LV305 protected mice against tumor growth in an NY-ESO-1-expressing CT26 lung metastasis model, with the protective effect abrogated upon depletion of CD8 T cells. Adoptive transfer of CD8 T cells, alone or together with CD4 T cells or natural killer cells, from LV305-immunized donor mice to tumor-bearing recipient mice conferred significant protection against metastatic tumor growth. Biodistribution of injected LV305 in mice was limited to the site of injection and the draining lymph node, and injected LV305 exhibited minimal excretion. Mice injected with LV305 developed little to no adverse effects, as evaluated by toxicology studies adherent to good laboratory practices. Taken together, these data support the development of LV305 as a clinical candidate for treatment against tumors expressing NY-ESO-1. PMID:27626061

  18. Peritrophin-like protein from Litopenaeus vannamei (LvPT) involved in white spot syndrome virus (WSSV) infection in digestive tract challenged with reverse gavage

    Science.gov (United States)

    Xie, Shijun; Li, Fuhua; Zhang, Xiaojun; Zhang, Jiquan; Xiang, Jianhai

    2017-05-01

    The peritrophic membrane plays an important role in the defense system of the arthropod gut. The digestive tract is considered one of the major tissues targeted by white spot syndrome virus (WSSV) in shrimp. In this study, the nucleotide sequence encoding peritrophin-like protein of Litopenaeus vannamei (LvPT) was amplified from a yeast two-hybrid library of L. vannamei. The epitope peptide of LvPT was predicted with the GenScript OptimumAntigen™ design tool. An anti-LvPT polyclonal antibody was produced and shown to specifically bind a band at 27 kDa, identified as LvPT. The LvPT protein was expressed and its concentration determined. LvPT dsRNA (4 μg per shrimp) was used to inhibit LvPT expression in shrimp, and a WSSV challenge experiment was then performed with reverse gavage. The pleopods, stomachs, and guts were collected from the shrimp at 0, 24, 48, and 72 h post-infection (hpi). Viral load quantification showed that the levels of WSSV were significantly lower in the pleopods, stomachs, and guts of shrimp after LvPT dsRNA interference than in those of the controls at 48 and 72 hpi. Our results imply that LvPT plays an important role during WSSV infection of the digestive tract.

  19. Modelling wetland-groundwater interactions in the boreal Kälväsvaara esker, Northern Finland

    Science.gov (United States)

    Jaros, Anna; Rossi, Pekka; Ronkanen, Anna-Kaisa; Kløve, Bjørn

    2016-04-01

    Many types of boreal peatland ecosystems such as alkaline fens, aapa mires and Fennoscandia spring fens rely on the presence of groundwater. In these ecosystems groundwater creates unique conditions for flora and fauna by providing water, nutrients and constant water temperature enriching local biodiversity. The groundwater-peatland interactions and their dynamics are not, however, in many cases fully understood and their measurement and quantification is difficult due to highly heterogeneous structure of peatlands and large spatial extend of these ecosystems. Understanding of these interactions and their changes due to anthropogenic impact on groundwater resources would benefit the protection of the groundwater dependent peatlands. The groundwater-peatland interactions were investigated using the fully-integrated physically-based groundwater-surface water code HydroGeoSphere in a case study of the Kälväsvaara esker aquifer, Northern Finland. The Kälväsvaara is a geologically complex esker and it is surrounded by vast aapa mire system including alkaline and springs fens. In addition, numerous small springs occur in the discharge zone of the esker. In order to quantify groundwater-peatland interactions a simple steady-state model was built and results were evaluated using expected trends and field measurements. The employed model reproduced relatively well spatially distributed hydrological variables such as soil water content, water depths and groundwater-surface water exchange fluxes within the wetland and esker areas. The wetlands emerged in simulations as a result of geological and topographical conditions. They could be identified by high saturation levels at ground surface and by presence of shallow ponded water over some areas. The model outputs exhibited also strong surface water-groundwater interactions in some parts of the aapa system. These areas were noted to be regions of substantial diffusive groundwater discharge by the earlier studies. In

  20. Dimensions of Creative Evaluation

    DEFF Research Database (Denmark)

    Christensen, Bo; Ball, Linden J.

    2016-01-01

    We examined evaluative reasoning taking place during expert ‘design critiques’. We focused on key dimensions of creative evaluation (originality, functionality and aesthetics) and ways in which these dimensions impact reasoning strategies and suggestions offered by experts for how the student could...... continue. Each dimension was associated with a specific underpinning ‘logic’ determining how these dimensions were evaluated in practice. Our analysis clarified how these dimensions triggered reasoning strategies such as running mental simulations or making design suggestions, ranging from ‘go...

  1. Extinction in the Galaxy from Surface Brightnesses of ESO-LV Galaxies : Determination of A_R/A_B ratio

    NARCIS (Netherlands)

    Choloniewski, J.; Valentijn, E. A.

    2003-01-01

    A new method for the determination of the extinction in the Galaxy is proposed. The method uses surface brightnesses of external galaxies in the B and R-bands. The observational data have been taken from the ESO-LV galaxy catalog. As a first application of our model we derive the ratio of R-band to

  2. Chemical abundances in the protoplanetary disk LV2 (Orion) - II: High dispersion VLT observations and microjet properties

    CERN Document Server

    Tsamis, Y G

    2011-01-01

    Integral field spectroscopy of the LV2 proplyd is presented taken with the VLT/FLAMES Argus array at an angular resolution of 0.31x0.31 arcsec^2 and velocity resolutions down to 2 km/s per pixel. Following subtraction of the local M42 emission, the spectrum of LV2 is isolated from the surrounding nebula. We measured the heliocentric velocities and widths of a number of lines detected in the intrinsic spectrum of the proplyd, as well as in the adjacent Orion nebula within a 6.6 x 4.2 arcsec^2 FoV. It is found that far-UV to optical collisional lines with critical densities, Ncrit, ranging from 10^3 to 10^9 /cm^3 suffer collisional de-excitation near the rest velocity of the proplyd correlating tightly with their critical densities. Lines of low Ncrit are suppressed the most. The bipolar jet arising from LV2 is spectrally and spatially well-detected in several emission lines. We compute the [O III] electron temperature profile across LV2 in velocity space and measure steep temperature variations associated with...

  3. Toxicity during l-LV/5FU adjuvant chemotherapy as a modified RPMI regimen for patients with colorectal cancer.

    Science.gov (United States)

    Hotta, Tsukasa; Takifuji, Katsunari; Arii, Kazuo; Yokoyama, Shozo; Matsuda, Kenji; Higashiguchi, Takashi; Tominaga, Toshiji; Oku, Yoshimasa; Yamaue, Hiroki

    2005-08-01

    l-leucovorin (LV)/5-fluorouracil (5FU) may play an important role, as an adjuvant chemotherapy, in improving the survival of patients with stage III colorectal cancer. However, severe toxicity of the chemotherapeutic agent could be fatal. Adverse effects, including bone marrow suppression, liver damage, renal damage, and glucose tolerance, were evaluated daily during 3 courses of l-LV/5FU-modified RPMI regimen adjuvant chemotherapy for 22 patients with stage III colorectal cancer. Decrease in the serum levels of neutrophils and platelets occurred in the 1st course, which became more obvious after three or four administrations of l-LV/5FU in the 1st course. Furthermore, serum levels of leukocytes, neutrophils, and platelets on the re-start day of this chemotherapy after 2-week intervals were lower than those on the start day of this chemotherapy. In the evaluation of liver damage, renal damage, and glucose tolerance; serum alanine aminotransferase level in the 2nd course, serum total bilirubin (T.Bil) level in the 1st course, and serum creatinine level in the 1st course deteriorated during the course. T.Bil levels on the re-start day of this chemotherapy after 2-week intervals were especially high compared to that on the start day. The more courses of this chemotherapy we perform, the more attention we must pay to bone marrow suppression and hyperbilirubinemia. Thus, we clarified the attentive point of side effect of l-LV/5FU adjuvant chemotherapy for colorectal cancer.

  4. The Real-Time Optimisation of DNO Owned Storage Devices on the LV Network for Peak Reduction

    Directory of Open Access Journals (Sweden)

    Matthew Rowe

    2014-05-01

    Full Text Available Energy storage is a potential alternative to conventional network reinforcement of the low voltage (LV distribution network to ensure the grid’s infrastructure remains within its operating constraints. This paper presents a study on the control of such storage devices, owned by distribution network operators. A deterministic model predictive control (MPC controller and a stochastic receding horizon controller (SRHC are presented, where the objective is to achieve the greatest peak reduction in demand, for a given storage device specification, taking into account the high level of uncertainty in the prediction of LV demand. The algorithms presented in this paper are compared to a standard set-point controller and bench marked against a control algorithm with a perfect forecast. A specific case study, using storage on the LV network, is presented, and the results of each algorithm are compared. A comprehensive analysis is then carried out simulating a large number of LV networks of varying numbers of households. The results show that the performance of each algorithm is dependent on the number of aggregated households. However, on a typical aggregation, the novel SRHC algorithm presented in this paper is shown to outperform each of the comparable storage control techniques.

  5. Impact of biogenic nanoscale metals Fe, Cu, Zn and Se on reproductive LV chickens

    Science.gov (United States)

    Khiem Nguyen, Quy; Dieu Nguyen, Duy; Kien Nguyen, Van; Thinh Nguyen, Khac; Chau Nguyen, Hoai; Tin Tran, Xuan; Nguyen, Huu Cuong; Tien Phung, Duc

    2015-09-01

    Using biogenic nanoscale metals (Fe, Cu, ZnO, Se) to supplement into diet premix of reproductive LV (a Vietnamese Luong Phuong chicken breed) chickens resulted in certain improvement of poultry farming. The experimental data obtained showed that the farming indices depend mainly on the quantity of nanocrystalline metals which replaced the inorganic mineral component in the feed premix. All four experimental groups with different quantities of the replacement nano component grew and developed normally with livability reaching 91 to 94%, hen’s bodyweight at 38 weeks of age and egg weight ranged from 2.53-2.60 kg/hen and 50.86-51.55 g/egg, respectively. All these farming indices together with laying rate, egg productivity and chick hatchability peaked at group 5 with 25% of nanoscale metals compared to the standard inorganic mineral supplement, while feed consumption was lowest. The results also confirmed that nanocrystalline metals Fe, Cu, ZnO and Se supplemented to chicken feed were able to decrease inorganic minerals in the diet premixes at least four times, allowing animals to more effectively absorb feed minerals, consequently decreasing environmental pollution risks.

  6. Smart MV/LV distribution transformer for Smart Grid with active prosumer participation

    Directory of Open Access Journals (Sweden)

    Marek Adamowicz

    2012-09-01

    Full Text Available With the development of distribution networks and their gradual transformation into intelligent Smart Grid type networks the relevance and share of controlled power converter systems used as interfaces between energy sources and the grid, and between grid and the recipients, will grow. This paper elaborates on the concept of replacing conventional 50 Hz distribution transformers with intelligent distribution transformers. A solution of a three-stage smart distribution transformer of modular design is proposed, oriented to connecting prosumers as active recipients of electricity with enhanced requirements, and owners of small renewable energy systems (RES. Two active stages: AC-DC on the MV side and DC-AC on the LV side provide the ability to compensate reactive power and shape voltage parameters. The simulation results presented here confi rm that the smart transformer’s intermediate stage, through the use of isolated DC-DC converters with high-speed semiconductor devices, provides the ability to quickly adjust the power flow between the primary and secondary sides.

  7. MV and LV Residential Grid Impact of Combined Slow and Fast Charging of Electric Vehicles

    Directory of Open Access Journals (Sweden)

    Niels Leemput

    2015-03-01

    Full Text Available This article investigates the combined low voltage (LV and medium voltage (MV residential grid impact for slow and fast electric vehicle (EV charging, for an increasing local penetration rate and for different residential slow charging strategies. A realistic case study for a Flemish urban distribution grid is used, for which three residential slow charging strategies are modeled: uncoordinated charging, residential off-peak charging, and EV-based peak shaving. For each slow charging strategy, the EV hosting capacity is determined, with and without the possibility of fast charging, while keeping the grid within its operating limits. The results show that the distribution grid impact is much less sensitive to the presence of fast charging compared to the slow charging strategy. EV-based peak shaving results in the lowest grid impact, allowing for the highest EV hosting capacity. Residential off-peak charging has the highest grid impact, due the load synchronization effect that occurs, resulting in the lowest EV hosting capacity. Therefore, the EV users should be incentivized to charge their EVs in a more grid-friendly manner when the local EV penetration rate becomes significant, as this increases the EV hosting capacity much more than the presence of fast charging decreases it.

  8. Characterization and DNA sequence of the mobilization region of pLV22a from Bacteroides fragilis.

    Science.gov (United States)

    Novicki, T J; Hecht, D W

    1995-08-01

    A 4.2-kb plasmid (pLV22a) native to Bacteroides fragilis LV22 became fused to a transfer-deficient Bacteroides spp.-Escherichia coli shuttle vector by an inverse transposition event, resulting in a transferrable phenotype. The transfer phenotype was attributable to pLV22a, which was also capable of mobilization within E. coli when coresident with the IncP beta R751 plasmid. Transposon mutagenesis with Tn1000 localized the mobilization region to a 1.5-kb DNA segment in pLV22a. The mobilization region has been sequenced, and five open reading frames have been identified. Mutants carrying disruptions in any of the three genes designated mbpA, mbpB, and mbpC and coding for deduced products of 11.3, 30.4, and 17.1 kDa, respectively, cannot be mobilized when coresident with R751. Mutations in all three genes can be complemented in the presence of the respective wild-type genes, indicating that the products of mbpA, mbpB, and mbpC have roles in the mobilization process and function in trans. The deduced 30.4-kDa MbpB protein contains a 14-amino-acid conserved motif that is also found in the DNA relaxases of a variety of conjugal and mobilizable plasmids and the conjugative transposon Tn4399. Deletion analysis and complementation experiments have localized a cis-acting region of pLV22a within mbpA.

  9. Gender-Based Differences in Cardiac Remodeling and ILK Expression after Myocardial Infarction

    Energy Technology Data Exchange (ETDEWEB)

    Sofia, Renato Rodrigues [Programa de Pós-graduação em Ciências da Reabilitação - Universidade Nove de Julho (Uninove), São Paulo, SP (Brazil); Departamento de Cardiologia - Universidade Federal de São Paulo, São Paulo, SP (Brazil); Serra, Andrey Jorge, E-mail: andreyserra@gmail.com; Silva, Jose Antonio Jr [Programa de Pós-graduação em Ciências da Reabilitação - Universidade Nove de Julho (Uninove), São Paulo, SP (Brazil); Antonio, Ednei Luiz [Departamento de Cardiologia - Universidade Federal de São Paulo, São Paulo, SP (Brazil); Manchini, Martha Trindade [Programa de Pós-graduação em Ciências da Reabilitação - Universidade Nove de Julho (Uninove), São Paulo, SP (Brazil); Oliveira, Fernanda Aparecida Alves de [Departamento de Cardiologia - Universidade Federal de São Paulo, São Paulo, SP (Brazil); Teixeira, Vicente Paulo Castro [Departamento de Patologia - Universidade Federal de São Paulo, São Paulo, SP (Brazil); Tucci, Paulo José Ferreira [Departamento de Cardiologia - Universidade Federal de São Paulo, São Paulo, SP (Brazil)

    2014-08-15

    Gender can influence post-infarction cardiac remodeling. To evaluate whether gender influences left ventricular (LV) remodeling and integrin-linked kinase (ILK) after myocardial infarction (MI). Female and male Wistar rats were assigned to one of three groups: sham, moderate MI (size: 20-39% of LV area), and large MI (size: ≥40% of LV area). MI was induced by coronary occlusion, and echocardiographic analysis was performed after six weeks to evaluate MI size as well as LV morphology and function. Real-time RT-PCR and Western blot were used to quantify ILK in the myocardium. MI size was similar between genders. MI resulted in systolic dysfunction and enlargement of end-diastolic as well as end-systolic dimension of LV as a function of necrotic area size in both genders. Female rats with large MI showed a lower diastolic and systolic dilatation than the respective male rats; however, LV dysfunction was similar between genders. Gene and protein levels of ILK were increased in female rats with moderate and large infarctions, but only male rats with large infarctions showed an altered ILK mRNA level. A negative linear correlation was evident between LV dimensions and ILK expression in female rats with large MI. Post-MI ILK expression is altered in a gender-specific manner, and higher ILK levels found in females may be sufficient to improve LV geometry but not LV function.

  10. Gender-Based Differences in Cardiac Remodeling and ILK Expression after Myocardial Infarction

    Directory of Open Access Journals (Sweden)

    Renato Rodrigues Sofia

    2014-08-01

    Full Text Available Background: Gender can influence post-infarction cardiac remodeling. Objective: To evaluate whether gender influences left ventricular (LV remodeling and integrin-linked kinase (ILK after myocardial infarction (MI. Methods: Female and male Wistar rats were assigned to one of three groups: sham, moderate MI (size: 20-39% of LV area, and large MI (size: ≥40% of LV area. MI was induced by coronary occlusion, and echocardiographic analysis was performed after six weeks to evaluate MI size as well as LV morphology and function. Real-time RT-PCR and Western blot were used to quantify ILK in the myocardium. Results: MI size was similar between genders. MI resulted in systolic dysfunction and enlargement of end-diastolic as well as end-systolic dimension of LV as a function of necrotic area size in both genders. Female rats with large MI showed a lower diastolic and systolic dilatation than the respective male rats; however, LV dysfunction was similar between genders. Gene and protein levels of ILK were increased in female rats with moderate and large infarctions, but only male rats with large infarctions showed an altered ILK mRNA level. A negative linear correlation was evident between LV dimensions and ILK expression in female rats with large MI. Conclusions: Post-MI ILK expression is altered in a gender-specific manner, and higher ILK levels found in females may be sufficient to improve LV geometry but not LV function.

  11. Shrimp with knockdown of LvSOCS2, a negative feedback loop regulator of JAK/STAT pathway in Litopenaeus vannamei, exhibit enhanced resistance against WSSV.

    Science.gov (United States)

    Wang, Sheng; Song, Xuan; Zhang, Zijian; Li, Haoyang; L, Kai; Yin, Bin; He, Jianguo; Li, Chaozheng

    2016-12-01

    JAK/STAT pathway is one of cytokine signaling pathways and mediates diversity immune responses to protect host from viral infection. In this study, LvSOCS2, a member of suppressor of cytokine signaling (SOCS) families, has been cloned and identified from Litopenaeus vannamei. The full length of LvSOCS2 is 1601 bp, including an 1194 bp open reading frame (ORF) coding for a putative protein of 397 amino acids with a calculated molecular weight of ∼42.3 kDa. LvSOCS2 expression was most abundant in gills and could respond to the challenge of LPS, Vibrio parahaemolyticus, Staphhylococcus aureus, Poly (I: C) and white spot syndrome virus (WSSV). There are several STAT binding motifs presented in the proximal promoter region of LvSOCS2 and its expression was induced by LvJAK or LvSTAT protein in a dose dependent manner, suggesting LvSOCS2 could be the transcriptional target gene of JAK/STAT pathway. Moreover, the transcription of DmVir-1, a read out of the activation of JAK/STAT pathway in Drosophila, was promoted by LvJAK but inhibited by LvSOCS2, indicating that LvSOCS2 could be a negative regulator in this pathway and thus can form a negative feedback loop. Our previous study indicated that shrimp JAK/STAT pathway played a positive role against WSSV. In this study, RNAi-mediated knockdown of LvSOCS2 shrimps showed lower susceptibility to WSSV infection and caused lessened virus loads, which further demonstrated that the JAK/STAT pathway could function as an anti-viral immunity in shrimp.

  12. Reversal of adaptive left ventricular atrophy following electrically-stimulated exercise training in human tetraplegics.

    Science.gov (United States)

    Nash, M S; Bilsker, S; Marcillo, A E; Isaac, S M; Botelho, L A; Klose, K J; Green, B A; Rountree, M T; Shea, J D

    1991-11-01

    Left ventricular (LV) myocardial atrophy and diminished cardiac function have been shown to accompany chronic human tetraplegia. These changes are attributable both to physical immobilisation and abnormal autonomic circulatory regulation imposed by a spinal cord injury (SCI). To test whether exercise training increases LV mass following chronic SCI, 8 neurologically complete quadriplegic males at 2 SCI rehabilitation and research centres underwent one month of electrically-stimulated quadriceps strengthening followed by 6 months of electrically-stimulated cycling exercise. Resting M-mode and 2-D echocardiograms were measured before and after exercise training to quantify the interventricular septal and posterior wall thicknesses at end-diastole (IVSTED and PWTED, respectively), and the LV internal dimension at end-diastole (LVIDED). LV mass was computed from these measurements using standard cube function geometry. Results showed a 6.5% increase in LVIDED following exercise training (p less than 0.02), with increases in IVSTED and PWTED of 17.8 (p less than 0.002) and 20.3% (p less than 0.01), respectively. Computed LV mass increased by 35% following exercise training (p = 0.002). These data indicate that myocardial atrophy is reversed in tetraplegics following electrically-stimulated exercise training, and that the changes in cardiac architecture are likely to be the result of both pressure and volume challenge to the heart imposed by exercise.

  13. User Experience Dimensions

    DEFF Research Database (Denmark)

    Lykke, Marianne; Jantzen, Christian

    2016-01-01

    The present study develops a set of 10 dimensions based on a systematic understanding of the concept of experience as a holistic psychological. Seven of these are derived from a psychological conception of what experiencing and experiences are. Three supplementary dimensions spring from...... the observation that experiences apparently have become especially valuable phenomena in Western societies. The 10 dimensions are tried out in a field study at the Center for Art and Media (ZKM) in Germany with the purpose to study their applicability in the evaluation of interactive sound archives. 29 walk......-alongs were carried out with 58 museums visitors. Our analysis showed that it was possible to identify the 10 experience dimensions in the study material. Some dimensions were expressed more frequently than others. The distribution of expressed dimensions and the content of the user comments provided a clear...

  14. Hollow dimension of modules

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    In this paper, we are interested in the following general question: Given a module Mwhich has finite hollow dimension and which has a finite collection of submodules Ki (1≤i≤n) such that M=K1+... +Kn, can we find an expression for the hollow dimension of Min terms of hollow dimensions of modules built up in some way from K1 Kn? We prove the following theorem:Let Mbe an amply supplemented module having finite hollow dimension and let Ki (1≤i≤n) be a finite collection of submodules of Msuch that M=K1+...+Kn. Then the hollow dimension h(M) of Mis the sum of the hollow dimensions of Ki (1≤i≤n) ifand only if Ki is a supplement of K1+...+Ki-1+Ki+1+...+Kn in Mfor each 1≤i≤n.

  15. Acumulación/eliminación de oxitetraciclina en el camarón blanco, lv y su residualidad en dietas artificiales

    OpenAIRE

    Montoya, Nelson; Reyes, Eduardo

    2002-01-01

    Acumulación/eliminación de oxitetraciclina en el camarón blanco, LV y su residualidad en dietas artificiales Acumulación/eliminación de oxitetraciclina en el camarón blanco, LV y su residualidad en dietas artificiales

  16. The Natural History of Left Ventricular Geometry in the Community: Clinical Correlates and Prognostic Significance of Change in LV Geometric Pattern

    Science.gov (United States)

    Lieb, Wolfgang; Gona, Philimon; Larson, Martin G.; Aragam, Jayashri; Zile, Michael R.; Cheng, Susan; Benjamin, Emelia J.; Vasan, Ramachandran S.

    2014-01-01

    Objectives We evaluated pattern and clinical correlates of change in left ventricular (LV) geometry over a 4-year period in the community; we also assessed whether the pattern of change in LV geometry over 4 years predicts incident cardiovascular disease (CVD), including myocardial infarction, heart failure and cardiovascular death during an additional subsequent follow-up period. Background It is unclear how LV geometric patterns change over time and whether changes in LV geometry have prognostic significance. Methods We evaluated 4492 observations (2604 unique Framingham Study participants attending consecutive examinations) to categorize LV geometry at baseline and after 4 years. Four groups were defined based on the sex-specific distributions of LV mass (LVM) and relative wall thickness (RWT) (normal: LVM and RWTgeometric pattern over 4 years was associated with increased CVD risk (140 events) during a subsequent median follow-up of 12.0 years (adjusted-hazards ratio, 1.59; 95%CI, 1.04–2.43). Conclusions Our longitudinal observations in the community suggest that dynamic changes in LV geometric pattern over time are common. Higher blood pressure and greater BMI are modifiable factors associated with the development of abnormal LV geometry, and such progression portends an adverse prognosis. PMID:25129518

  17. La respuesta inmunitaria celular del camarón lv y su utilidad en el control de la enfermedad en estanques

    OpenAIRE

    Motesdeoca, Mercedes; Amano, Yasuji; Echeverría, Fabrizio; Betancourt, Irma; Panchana, Fanny; Sotomayor, Mariuxi; Rodríguez, Jenny

    2002-01-01

    La respuesta inmunitaria celular del camarón LV y su utilidad en el control de la enfermedad en estanques La respuesta inmunitaria celular del camarón LV y su utilidad en el control de la enfermedad en estanques

  18. Dimension of linear models

    DEFF Research Database (Denmark)

    Høskuldsson, Agnar

    1996-01-01

    Determination of the proper dimension of a given linear model is one of the most important tasks in the applied modeling work. We consider here eight criteria that can be used to determine the dimension of the model, or equivalently, the number of components to use in the model. Four...... the basic problems in determining the dimension of linear models. Then each of the eight measures are treated. The results are illustrated by examples....

  19. SVM-based classification of LV wall motion in cardiac MRI with the assessment of STE

    Science.gov (United States)

    Mantilla, Juan; Garreau, Mireille; Bellanger, Jean-Jacques; Paredes, José Luis

    2015-01-01

    In this paper, we propose an automated method to classify normal/abnormal wall motion in Left Ventricle (LV) function in cardiac cine-Magnetic Resonance Imaging (MRI), taking as reference, strain information obtained from 2D Speckle Tracking Echocardiography (STE). Without the need of pre-processing and by exploiting all the images acquired during a cardiac cycle, spatio-temporal profiles are extracted from a subset of radial lines from the ventricle centroid to points outside the epicardial border. Classical Support Vector Machines (SVM) are used to classify features extracted from gray levels of the spatio-temporal profile as well as their representations in the Wavelet domain under the assumption that the data may be sparse in that domain. Based on information obtained from radial strain curves in 2D-STE studies, we label all the spatio-temporal profiles that belong to a particular segment as normal if the peak systolic radial strain curve of this segment presents normal kinesis, or abnormal if the peak systolic radial strain curve presents hypokinesis or akinesis. For this study, short-axis cine- MR images are collected from 9 patients with cardiac dyssynchrony for which we have the radial strain tracings at the mid-papilary muscle obtained by 2D STE; and from one control group formed by 9 healthy subjects. The best classification performance is obtained with the gray level information of the spatio-temporal profiles using a RBF kernel with 91.88% of accuracy, 92.75% of sensitivity and 91.52% of specificity.

  20. Multiple dimensions of performance

    NARCIS (Netherlands)

    Torenvlied, René

    2013-01-01

    This presentation considers the multiple dimensions of performance in performance studies, and potentially contradicting effects of different management strategies on separate indicators of performance

  1. Dimension of Physical Space

    Directory of Open Access Journals (Sweden)

    Quznetsov G.

    2014-10-01

    Full Text Available Each vector of state has its own corresponing element of the CayleyDickson algebra. Properties of a state vector require that this algebra was a normalized division algebra. By the Hurwitz and Frobenius theorems maximal dimension of s uch algebra is 8. Con- sequently, a dimension of corresponding complex state vectors is 4, and a dimension of the Clifford set elements is 4 × 4. Such set contains 5 matrices — among them — 3-diagonal. Hence, a dimension of the dot events space is equal to 3 + 1.

  2. Regulation of FeLV-945 by c-Myb binding and CBP recruitment to the LTR

    Directory of Open Access Journals (Sweden)

    Finstad Samantha L

    2004-09-01

    Full Text Available Abstract Background Feline leukemia virus (FeLV induces degenerative, proliferative and malignant hematologic disorders in its natural host, the domestic cat. FeLV-945 is a viral variant identified as predominant in a cohort of naturally infected animals. FeLV-945 contains a unique sequence motif in the long terminal repeat (LTR comprised of a single copy of transcriptional enhancer followed by a 21-bp sequence triplicated in tandem. The LTR is precisely conserved among independent cases of multicentric lymphoma, myeloproliferative disease and anemia in animals from the cohort. The 21-bp triplication was previously shown to act as a transcriptional enhancer preferentially in hematopoietic cells and to confer a replicative advantage. The objective of the present study was to examine the molecular mechanism by which the 21-bp triplication exerts its influence and the selective advantage responsible for its precise conservation. Results Potential binding sites for the transcription factor, c-Myb, were identified across the repeat junctions of the 21-bp triplication. Such sites would not occur in the absence of the repeat; thus, a requirement for c-Myb binding to the repeat junctions of the triplication would exert a selective pressure to conserve its sequence precisely. Electrophoretic mobility shift assays demonstrated specific binding of c-Myb to the 21-bp triplication. Reporter gene assays showed that the triplication-containing LTR is responsive to c-Myb, and that responsiveness requires the presence of both c-Myb binding sites. Results further indicated that c-Myb in complex with the 21-bp triplication recruits the transcriptional co-activator, CBP, a regulator of normal hematopoiesis. FeLV-945 replication was shown to be positively regulated by CBP in a manner dependent on the presence of the 21-bp triplication. Conclusion Binding sites for c-Myb across the repeat junctions of the 21-bp triplication may account for its precise conservation in

  3. Chemical abundances in the protoplanetary disc LV 2 (Orion) - II. High-dispersion VLT observations and microjet properties

    Science.gov (United States)

    Tsamis, Y. G.; Walsh, J. R.

    2011-11-01

    Integral field spectroscopy of the LV 2 proplyd is presented taken with the Very Large Telescope (VLT)/FLAMES Argus array at an angular resolution of 0.31 × 0.31 arcsec2 and velocity resolutions down to 2 km s-1 pixel-1. Following subtraction of the local M42 emission, the spectrum of LV 2 is isolated from the surrounding nebula. We measured the heliocentric velocities and widths of a number of lines detected in the intrinsic spectrum of the proplyd, as well as in the adjacent Orion nebula falling within a 6.6 × 4.2 arcsec2 field of view. It is found that far-ultraviolet to optical collisional lines with critical densities, Ncr, ranging from 103 to 109 cm-3 suffer collisional de-excitation near the rest velocity of the proplyd correlating tightly with their critical densities. Lines of low Ncr are suppressed the most. The bipolar jet arising from LV 2 is spectrally and spatially well detected in several emission lines. We compute the [O III] electron temperature profile across LV 2 in velocity space and measure steep temperature variations associated with the red-shifted lobe of the jet, possibly being due to a shock discontinuity. From the velocity-resolved analysis the ionized gas near the rest frame of LV 2 has Te= 9200 ± 800 K and Ne˜ 106 cm-3, while the red-shifted jet lobe has Te≈ 9000-104 K and Ne˜ 106-107 cm-3. The jet flow is highly ionized but contains dense semineutral clumps emitting neutral oxygen lines. The abundances of N+, O2 +, Ne2 +, Fe2 +, S+and S2 +are measured for the strong red-shifted jet lobe. Iron in the core of LV 2 is depleted by 2.54 dex with respect to solar as a result of sedimentation on dust, whereas the efficient destruction of dust grains in the fast microjet raises its Fe abundance to at least 30 per cent solar. Sulphur does not show evidence of significant depletion on dust, but its abundance both in the core and the jet is only about half solar. Based on observations made with ESO telescopes at the Paranal Observatory

  4. Feline immunodeficiency virus (FIV, feline leukaemia virus (FeLV and Leishmania sp. in domestic cats in the Midwest of Brazil

    Directory of Open Access Journals (Sweden)

    Daniella Poffo

    Full Text Available ABSTRACT: This search aimed to investigate FIV and FeLV infections in domestic cats, analysing the epidemiological profile of the disease as well as additional infection with Leishmania sp. We evaluated 88 domestic cats for the presence of FIV, FeLV and Leishmania sp. infection. Eleven (12.5% cats were positive for FIV infection, four (4.5% were positive for FeLV, and two were co-infected. However, none was infected with Leishmania sp. The prevalence for FIV infection was higher than FeLV, and those observed in other regions, but no factor was associated with the infection by FIV and FeLV in this study.

  5. THE DISTRIBUTIONAL DIMENSION OF FRACTALS

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In the book [1] H.Triebel introduces the distributional dimension of fractals in and distributional dimension, respectively. Thus we might say that the distributional dimension is an analytical definition for Hausdorff dimension. Therefore we can study Hausdorff dimension through the distributional dimension analytically.By discussing the distributional dimension, this paper intends to set up a criterion for estimating the upper and lower bounds of Hausdorff dimension analytically. Examples illustrating the criterion are included in the end.

  6. 10A1-MuLV but not the related amphotropic 4070A MuLV is highly neurovirulent: importance of sequences upstream of the structural Gag coding region.

    Science.gov (United States)

    Münk, Carsten; Prassolov, Vladimir; Rodenburg, Michaela; Kalinin, Viacheslav; Löhler, Jürgen; Stocking, Carol

    2003-08-15

    Recombinants of Moloney murine leukemia virus (MoMuLV) with either an amphotropic (MoAmphoV) or 10A1-tropic host range (Mo10A1V) induce a spongiform neurodegenerative disease in susceptible mice. To test whether MoMuLV -derived sequences are required for induction of neuropathology, mice were inoculated with either the original 10A1 or the amphotropic (4070A) MuLV isolate. Strikingly, wild-type 10A1 was more neurovirulent than Mo10A1V, inducing severe neurological clinical symptoms with a median latency of 99 days in 100% of infected mice. In contrast, no motor disturbances were detected in any of the 4070A-infected mice, although limited central nervous system lesions were observed. A viral determinant conferring high neurovirulence to 10A1 was mapped to a region encompassing the first 676 bases of the viral genome, including the U5 LTR and encoding the amino-terminus of glycosylated Gag (glycoGag). In contrast to studies with the highly neurovirulent CasFr(KP) virus, an inverse correlation between surface expression levels of glycoGag and neurovirulence was not observed; however, this does not rule out a common underlying mechanism regulating virus pathogenicity.

  7. Zygotic LvBMP5-8 is required for skeletal patterning and for left-right but not dorsal-ventral specification in the sea urchin embryo.

    Science.gov (United States)

    Piacentino, Michael L; Chung, Oliver; Ramachandran, Janani; Zuch, Daniel T; Yu, Jia; Conaway, Evan A; Reyna, Arlene E; Bradham, Cynthia A

    2016-04-01

    Skeletal patterning in the sea urchin embryo requires coordinated signaling between the pattern-dictating ectoderm and the skeletogenic primary mesenchyme cells (PMCs); recent studies have begun to uncover the molecular basis for this process. Using an unbiased RNA-Seq-based screen, we have previously identified the TGF-ß superfamily ligand, LvBMP5-8, as a skeletal patterning gene in Lytechinus variegatus embryos. This result is surprising, since both BMP5-8 and BMP2/4 ligands have been implicated in sea urchin dorsal-ventral (DV) and left-right (LR) axis specification. Here, we demonstrate that zygotic LvBMP5-8 is required for normal skeletal patterning on the left side, as well as for normal PMC positioning during gastrulation. Zygotic LvBMP5-8 is required for expression of the left-side marker soxE, suggesting that LvBMP5-8 is required for left-side specification. Interestingly, we also find that LvBMP5-8 knockdown suppresses serotonergic neurogenesis on the left side. While LvBMP5-8 overexpression is sufficient to dorsalize embryos, we find that zygotic LvBMP5-8 is not required for normal DV specification or development. In addition, ectopic LvBMP5-8 does not dorsalize LvBMP2/4 morphant embryos, indicating that, in the absence of BMP2/4, BMP5-8 is insufficient to specify dorsal. Taken together, our data demonstrate that zygotic LvBMP5-8 signaling is essential for left-side specification, and for normal left-side skeletal and neural patterning, but not for DV specification. Thus, while both BMP2/4 and BMP5-8 regulate LR axis specification, BMP2/4 but not zygotic BMP5-8 regulates DV axis specification in sea urchin embryos.

  8. Left atrial dimension and atrial fibrillation in surgical heart disease patients

    Institute of Scientific and Technical Information of China (English)

    Kaihu Shi; Peisheng Liu; David Shek; Hongwei Shi; Ying Yu; Fei Ye; Xinwei Mu; Youxiang Zhang; Leiyang Zhang; Junjie Shao; Rui Wang

    2008-01-01

    Objective The effect of left atrial (LA) dimension on the occurrence of atrial fibrillation (AF) has been examined in some small studies.Less is known about the relationship of LA dimension,hemodynamic with AF during echocardiographic evaluation,especially,the flow dynamics in LA poorly described.The objective of this study was to investigate the relationship between LA dimension and the occurrence of AE Methods Two hundred and forty-five consecutive patients with heart disease scheduled to undergo open heart surgery were prospectively enrolled in the study.Patients were divided into 2 groups according to atrial fibrillation:AF group (n=148,99 men and 49 women,with a mean age 59.3+8.4 years),and no-AF group (n= 97,60 men and 37 womem).Echocardiography was performed before surgery.All measurements were performed following the American Society of Echocardiography recommendations.Results There were more patients with congestive heart failure in AF group than in no-AF group (45.9% vs 39.1%,P <0.05).The mean LA volume was 49.2±12.2 ml/m2 in AF group and 33.1±10.8 ml/m2 in no-AF group.There were also significant differences between two groups in left atrial end systolic dimension (LAESD) (50±13mm vs 27±14mm),left atrial end diastolic dimension (LAEDD) (79±17mm vs 53±13mm),PA pressure ( 41.3+11.6 mmHg vs 37.5±10.4 mmHg),and ratio of mitral E velocity and septal mitral annulus motion velocity (E/E') .The percentage of abnormal diastolic function grades (DGF) was also higher in AF than in no-AF group (89.9% versus 59.8% );.Conclusion Atrial fibrillation is associated more frequently with an increased LA dimension and more severe atrial hemodynamics disorder.(J Geriatr Cardiol 2008;5:11-4)

  9. Optimization of cDNA amplification of Apricot Latent Virus (ApLV) from various plant tissues sources.

    Science.gov (United States)

    Gumus, M; Sipahioğlu, H M; Paylan, I C; Erkan, S

    2007-03-15

    Although the reverse transcriptase polymerase chain reaction (RT-PCR) procedure is basically simple operation, often it is not possible to achieve optimum results without optimizing the protocols. An RT-PCR method targeting a 200 bp sequence of the CP gene of Apricot Latent Virus (ApLV) was used as a model to improve the detection limit and to compare the behavior of three different plant tissues in a RT-PCR assay. A number of factors should be considered when selecting the optimal system for RT-PCR. Important considerations include the optimal concentrations of MgCl2, dNTP, Taq DNA polymerase enzyme, specific primer and the amount of cDNA for the downstream applications. This study therefore discusses a series of critical PCR parameters and feasible strategies for optimization of RT-PCR detection of ApLV.

  10. Recognizing the fingerprints of the Galactic bar: a quantitative approach to comparing model (l,v) distributions to observation

    CERN Document Server

    Sormani, Mattia C

    2014-01-01

    We present a new method for fitting simple hydrodynamical models to the (l,v) distribution of atomic and molecular gas observed in the Milky Way. The method works by matching features found in models and observations. It is based on the assumption that the large-scale features seen in (l,v) plots, such as ridgelines and the terminal velocity curve, are influenced primarily by the underlying large-scale Galactic potential and are only weakly dependent on local ISM heating and cooling processes. In our scheme one first identifies by hand the features in the observations: this only has to be done once. We describe a procedure for automatically extracting similar features from simple hydrodynamical models and quantifying the "distance" between each model's features and the observations. Application to models of the Galactic Bar region (|l|<30deg) shows that our feature-fitting method performs better than \\chi^2 or envelope distances at identifying the correct underlying galaxy model.

  11. User Experience Dimensions

    DEFF Research Database (Denmark)

    Lykke, Marianne; Jantzen, Christian

    2016-01-01

    The present study develops a set of 10 dimensions based on a systematic understanding of the concept of experience as a holistic psychological. Seven of these are derived from a psychological conception of what experiencing and experiences are. Three supplementary dimensions spring from the obser...

  12. Gorenstein homological dimensions

    DEFF Research Database (Denmark)

    Holm, Henrik Granau

    2004-01-01

    In basic homological algebra, the projective, injective and 2at dimensions of modules play an important and fundamental role. In this paper, the closely related Gorenstein projective, Gorenstein injective and Gorenstein 2at dimensions are studied. There is a variety of nice results about Gorenstein...

  13. Gorenstein homological dimensions

    DEFF Research Database (Denmark)

    Holm, Henrik Granau

    2004-01-01

    In basic homological algebra, the projective, injective and 2at dimensions of modules play an important and fundamental role. In this paper, the closely related Gorenstein projective, Gorenstein injective and Gorenstein 2at dimensions are studied. There is a variety of nice results about Gorenstein...

  14. MV/LV PDS transformers: Novel approach for the maximization of the preventive maintenance activities- A case study

    OpenAIRE

    Mahmoudi Morad; El barkany Abdellah; El khalfi Ahmed

    2013-01-01

    In today’s energy market in Morocco, a stable and reliable electric power supply system is an inevitable prerequisite for the technological and economic growth of the kingdom. Due to this, manypublic distribution companies are increasing their competitiveness by adopting new maintenance philosophies to reduce their Operation and Maintenance (O&M) costs. Indeed, being one of the most important parts of the medium voltage network, MV/LV public distribution substations transformer (PDS) play a k...

  15. A Preliminary Analysis of LV Kun's Conception of Sage%吕坤的圣人观浅析

    Institute of Scientific and Technical Information of China (English)

    萧自强

    2011-01-01

    吕坤认为,在圣人的内涵上,圣人能够把握天理,与天理合一,并且能够达到无心而无境的地位,能够超越性情之限制;在圣人的成长上,吕坤认为圣人可以通过修身",克己复礼"而达到;在圣人与众人之关系上,吕坤认为,圣人与众人并不是完全割裂的,圣人即超越于众人,又生活在众人之中。%On the connotation of sage,LV Kun esteemed that sage could grasp the natural principle and united it,got the position without the mind and the state,and went beyond the restrictions of temper.On the growth of the sage,LV Kun thought that sage could be self-cultivation,achieved with "Denying self and observing the proprieties".And on the relationships between the sage and the masses,LV Kun acknowledged that the sage and the masses were not completely separated,namely,the sage transcended the masses,and also,the sage could'nt go beyond them.

  16. Exercise Training in Athletes with Bicuspid Aortic Valve Does Not Result in Increased Dimensions and Impaired Performance of the Left Ventricle

    Directory of Open Access Journals (Sweden)

    Laura Stefani

    2014-01-01

    Full Text Available Background. Bicuspid aortic valve (BAV is one of the most common congenital heart disease (0.9%–2% and is frequently found in the athletes and in the general population. BAV can lead to aortic valve dysfunction and to a progressive aortic dilatation. Trained BAV athletes exhibit a progressive enlargement of the left ventricle (LV compared to athletes with normal aortic valve morphology. The present study investigates the possible relationship between different aortic valve morphology and LV dimensions. Methods. In the period from 2000 to 2011, we investigated a total of 292 BAV subjects, divided into three different groups (210 athletes, 59 sedentaries, and 23 ex-athletes. A 2D echocardiogram exam to classify BAV morphology and measure the standard LV systo-diastolic parameters was performed. The study was conducted as a 5-year follow-up echocardiographic longitudinal and as cross-sectional study. Results. Typical BAV was more frequent in all three groups (68% athletes, 67% sedentaries, and 63% ex-athletes than atypical. In BAV athletes, the typical form was found in 51% (107/210 of soccer players, 10% (21/210 of basketball players, 10% track and field athletics (20/210, 8% (17/210 of cyclists, 6% (13/210 swimmers, and 15% (32/210 of rugby players and others sport. Despite a progressive enlargement of the LV (P<0.001 observed during the follow-up study, no statistical differences of the LV morphology and function were evident among the diverse BAV patterns either in sedentary subjects or in athletes. Conclusion. In a large population of trained BAV athletes, with different prevalence of typical and atypical BAV type, there is a progressive nonstatistically significant enlargement of the LV. In any case, the dimensions of the LV remained within normal range. The metabolic requirements of the diverse sport examined in the present investigations do not seem to produce any negative impact in BAV athletes

  17. Quantification of left ventricular remodeling in response to isolated aortic or mitral regurgitation

    Directory of Open Access Journals (Sweden)

    Comeau Cindy

    2010-05-01

    Full Text Available Abstract Background The treatment of patients with aortic regurgitation (AR or mitral regurgitation (MR relies on the accurate assessment of the severity of the regurgitation as well as its effect on left ventricular (LV size and function. Cardiovascular Magnetic Resonance (CMR is an excellent tool for quantifying regurgitant volumes as well as LV size and function. The 2008 AHA/ACC management guidelines for the therapy of patients with AR or MR only describe LV size in terms of linear dimensions (i.e. end-diastolic and end-systolic dimension. LV volumes that correspond to these linear dimensions have not been published in the peer-reviewed literature. The purpose of this study is to determine the effect of regurgitant volume on LV volumes and chamber dimensions in patients with isolated AR or MR and preserved LV function. Methods Regurgitant volume, LV volume, mass, linear dimensions, and ejection fraction, were determined in 34 consecutive patients with isolated AR and 23 consecutive patients with MR and no other known cardiac disease. Results There is a strong, linear relationship between regurgitant volume and LV end-diastolic volume index (aortic regurgitation r2 = 0.8, mitral regurgitation r2 = 0.8. Bland-Altman analysis of regurgitant volume shows little interobserver variation (AR: 0.6 ± 4 ml; MR 4 ± 6 ml. The correlation is much poorer between regurgitant volume and commonly used clinical linear measures such as end-systolic dimension (mitral regurgitation r2 = 0.3, aortic regurgitation r2 = 0.5. For a given regurgitant volume, AR causes greater LV enlargement and hypertrophy than MR. Conclusion CMR is an accurate and robust technique for quantifying regurgitant volume in patients with AR or MR. Ventricular volumes show a stronger correlation with regurgitant volume than linear dimensions, suggesting LV volumes better reflect ventricular remodeling in patients with isolated mitral or aortic regurgitation. Ventricular volumes that

  18. Regulation of the immediate-early genes of white spot syndrome virus by Litopenaeus vannamei kruppel-like factor (LvKLF).

    Science.gov (United States)

    Huang, Ping-Han; Lu, Shao-Chia; Yang, Shu-Han; Cai, Pei-Si; Lo, Chu-Fang; Chang, Li-Kwan

    2014-10-01

    Kruppel-like factors (KLFs) belong to a subclass of Cys2/His2 zinc-finger DNA-binding proteins, and act as important regulators with diverse roles in cell growth, proliferation, differentiation, apoptosis and tumorigenesis. Our previous research showed that PmKLF from Penaeus monodon is crucial for white spot syndrome virus (WSSV) infection, yet the mechanisms by which PmKLF influences WSSV infection remain unclear. This study cloned KLF from Litopenaeus vannamei (LvKLF), which had 93% similarity with PmKLF. LvKLF formed a dimer via the C-terminal zinc-finger motif. Knockdown of LvKLF expression by dsRNA injection in WSSV-challenged shrimps was found to significantly inhibit the transcription of two important immediate-early (IE) genes, IE1 and WSSV304, and also reduced WSSV copy numbers. Moreover, reporter assays revealed that the promoter activities of these two WSSV IE genes were substantially enhanced by LvKLF. Mutations introduced in the promoter sequences of IE1 and WSSV304 were shown to abolish LvKLF activation of promoter activities; and an electrophoretic mobility shift assay demonstrated that LvKLF binds to putative KLF-response elements (KRE) in the promoters. Taken together, these results indicate that LvKLF transcriptional regulation of key IE genes is critical to WSSV replication.

  19. Females have greater left ventricular twist mechanics than males during acute reductions to preload.

    Science.gov (United States)

    Williams, Alexandra M; Shave, Rob E; Stembridge, Mike; Eves, Neil D

    2016-07-01

    Compared to males, females have smaller left ventricular (LV) dimensions and volumes, higher ejection fractions (EF), and higher LV longitudinal and circumferential strain. LV twist mechanics determine ventricular function and are preload-dependent. Therefore, the sex differences in LV structure and myocardial function may result in different mechanics when preload is altered. This study investigated sex differences in LV mechanics during acute challenges to preload. With the use of conventional and speckle-tracking echocardiography, LV structure and function were assessed in 20 males (24 ± 6.2 yr) and 20 females (23 ± 3.1 yr) at baseline and during progressive levels of lower body negative pressure (LBNP). Fourteen participants (8 males, 6 females) were also assessed following a rapid infusion of saline. LV end-diastolic volume, end-systolic volume, stroke volume (SV), and EF were reduced in both groups during LBNP (P mechanics following saline infusion. Females have larger LV twist and a faster untwisting velocity than males during large reductions to preload, supporting that females have a greater reliance on LV twist mechanics to maintain SV during severe reductions to preload.

  20. Dimensions of Openness

    DEFF Research Database (Denmark)

    Dalsgaard, Christian; Thestrup, Klaus

    2015-01-01

    as a matter of engaging educational activities in sociocultural practices of a surrounding society. Openness is not only a matter of opening up the existing, but of developing new educational practices that interact with society. The paper outlines three pedagogical dimensions of openness: transparency...... practices. Openness as joint engagement in the world aims at establishing interdependent collaborative relationships between educational institutions and external practices. To achieve these dimensions of openness, educational activities need to change and move beyond the course as the main format...... for openness. With examples from a university case, the paper discusses how alternative pedagogical formats and educational technologies can support the three dimensions of openness....

  1. The fourth dimension

    CERN Document Server

    Rucker, Rudy

    2014-01-01

    ""This is an invigorating book, a short but spirited slalom for the mind."" - Timothy Ferris, The New York Times Book Review ""Highly readable. One is reminded of the breadth and depth of Hofstadter's Gödel, Escher, Bach."" - Science""Anyone with even a minimal interest in mathematics and fantasy will find The Fourth Dimension informative and mind-dazzling... [Rucker] plunges into spaces above three with a zest and energy that is breathtaking."" - Martin Gardner ""Those who think the fourth dimension is nothing but time should be encouraged to read The Fourth Dimension, along with anyone else

  2. DIFFERENT DIMENSIONS OF TEAMS

    Directory of Open Access Journals (Sweden)

    Goparaju Purna SUDHAKAR

    2014-01-01

    Full Text Available Popularity ofteams is growing in 21st Century. Organizations are getting theirwork done through different types of teams. Teams have proved that thecollective performance is more than the sum of the individual performances.Thus, the teams have got different dimensions such as quantitative dimensionsand qualitative dimensions. The Quantitative dimensions of teams such as teamperformance, team productivity, team innovation, team effectiveness, teamefficiency, team decision making and team conflicts and Qualitative dimensionsof teams such as team communication, team coordination, team cooperation, teamcohesion, team climate, team creativity, team leadership and team conflictshave been discussed in this article.

  3. Dimension control of Superradiance

    Science.gov (United States)

    Hill, Tyler; Hui Deng Collaboration; Barry C. Sanders Collaboration

    2016-05-01

    We develop a theory for quantum dipole-dipole coupling when the electromagnetic fields are confined to an open line, open plane, or open space, commensurate with experimental capability for collective atomic effects subject to dimensional confinement. Our mathematical model naturally interpolates for all real dimension between one dimension for the line to three dimensions for open space. We show how superradiant emission can be controlled by dimensional confinement, including near-field and dipole-orientation effects, and we propose a two-dimensional confinement experiment to test our theory's efficacy. University of Michigan.

  4. Effective RNA-silencing strategy of Lv-MSTN/GDF11 gene and its effects on the growth in shrimp, Litopenaeus vannamei.

    Science.gov (United States)

    Lee, Ji-Hyun; Momani, Jalal; Kim, Young Mog; Kang, Chang-Keun; Choi, Jung-Hwa; Baek, Hae-Ja; Kim, Hyun-Woo

    2015-01-01

    Myostatin (MSTN), also known as GDF8, is a member of the transforming growth factor-β (TGF-β) superfamily and plays an important role in muscle growth, development, and differentiation. Recently, Lv-MSTN/GDF11, the primitive isoform of MSTN and GDF11, was identified from the shrimp Litopenaeus vannamei. The major production site for Lv-MSTN/GDF11 is in the heart, not the tail muscle, which differs from MSTNs in mammals. Among the three injected RNAs, long dsRNA was the most effective for Lv-MSTN/GDF11 knockdown and transcripts of Lv-MSTN/GDF11 decreased in both the heart (88.85%) and skeletal muscles (43.36%) 72h after injection of 10pmol of long dsRNA. We also found that higher doses of dsRNA did not lead to greater decreases in Lv-MSTN/GDF11 transcripts for amounts between 1pmol and 100pmol. Injection of Lv-MSTN/GDF11 dsRNA did not affect the upregulation of the skeletal actin gene (Lv-ACTINSK) in the tail muscle, but the expression of cytoplasmic and cardiac actins were upregulated in both the heart and tail muscle. Over the course of 8weeks of dsRNA injection, considerably higher mortality (~71%) was seen in the dsRNA-injected group compared to the control group (40%). Surviving shrimp in the dsRNA injected group had a lower growth rate due to the adverse effects of Lv-MSTN/GDF11 knockdown. Lv-MSTN/GDF11 appears to be involved in muscular or neuronal development, but not in doubling muscle fibers, as is the case with mammalian MSTN. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Anti-lipopolysaccharide factor in Litopenaeus vannamei (LvALF): a broad spectrum antimicrobial peptide essential for shrimp immunity against bacterial and fungal infection.

    Science.gov (United States)

    de la Vega, Enrique; O'Leary, Nuala A; Shockey, Jessica E; Robalino, Javier; Payne, Caroline; Browdy, Craig L; Warr, Gregory W; Gross, Paul S

    2008-04-01

    Antimicrobial peptides are an essential component of the innate immune system of most organisms. Expressed sequence tag analysis from various shrimp (Litopenaeus vannamei) tissues revealed transcripts corresponding to two distinct sequences (LvALF1 and LvALF2) with strong sequence similarity to anti-lipopolysaccharide factor (ALF), an antimicrobial peptide originally isolated from the horseshoe crab Limulus polyphemus. Full-length clones contained a 528bp transcript with a predicted open reading frame coding for 120 amino acids in LvALF1, and a 623bp transcript with a predicted open reading frame coding for 93 amino acids in LvALF2. A reverse genetic approach was implemented to study the in vivo role of LvALF1 in protecting shrimp from bacterial, fungal and viral infections. Injection of double-stranded RNA (dsRNA) corresponding to the LvALF1 message resulted in a significant reduction of LvALF1 mRNA transcript abundance as determined by qPCR. Following knockdown, shrimp were challenged with low pathogenic doses of Vibrio penaeicida, Fusarium oxysporum or white spot syndrome virus (WSSV) and the resulting mortality curves were compared with controls. A significant increase of mortality in the LvALF1 knockdown shrimp was observed in the V. penaeicida and F. oxysporum infections when compared to controls, showing that this gene has a role in protecting shrimp from both bacterial and fungal infections. In contrast, LvALF1 dsRNA activated the sequence-independent innate anti-viral immune response giving increased protection from WSSV infection.

  6. EF & den sociale dimension

    DEFF Research Database (Denmark)

    Due, Jesper Jørgen; Madsen, Jørgen Steen; Jensen, Carsten Strøby

    En analyse af EU's institutioner og udviklingen af den sociale dimension i forbindelse med etbaleringen af det indre marked med særlig henblik på effekterne på det danske aftalesystem.......En analyse af EU's institutioner og udviklingen af den sociale dimension i forbindelse med etbaleringen af det indre marked med særlig henblik på effekterne på det danske aftalesystem....

  7. Rokhlin Dimension for Flows

    Science.gov (United States)

    Hirshberg, Ilan; Szabó, Gábor; Winter, Wilhelm; Wu, Jianchao

    2017-07-01

    We introduce a notion of Rokhlin dimension for one parameter automorphism groups of {C^*}-algebras. This generalizes Kishimoto's Rokhlin property for flows, and is analogous to the notion of Rokhlin dimension for actions of the integers and other discrete groups introduced by the authors and Zacharias in previous papers. We show that finite nuclear dimension and absorption of a strongly self-absorbing {C^*}-algebra are preserved under forming crossed products by flows with finite Rokhlin dimension, and that these crossed products are stable. Furthermore, we show that a flow on a commutative {C^*}-algebra arising from a free topological flow has finite Rokhlin dimension, whenever the spectrum is a locally compact metrizable space with finite covering dimension. For flows that are both free and minimal, this has strong consequences for the associated crossed product {C^{*}}-algebras: Those containing a non-zero projection are classified by the Elliott invariant (for compact manifolds this consists of topological {K}-theory together with the space of invariant probability measures and a natural pairing given by the Ruelle-Sullivan map).

  8. A variational principle for the Hausdorff dimension of fractal sets

    DEFF Research Database (Denmark)

    Olsen, Lars; Cutler, Colleen D.

    1994-01-01

    Matematik, fraktal (fractal), Hausdorff dimension, Renyi dimension, pakke dimension (packing dimension)......Matematik, fraktal (fractal), Hausdorff dimension, Renyi dimension, pakke dimension (packing dimension)...

  9. Simple area-based measurement for multidetector computed tomography to predict left ventricular size

    Energy Technology Data Exchange (ETDEWEB)

    Schlett, Christopher L.; Kwait, Dylan C.; Mahabadi, Amir A.; Hoffmann, Udo [Massachusetts General Hospital, and Harvard Medical School, Cardiac MR PET CT Program, Boston, MA (United States); Bamberg, Fabian [Massachusetts General Hospital, and Harvard Medical School, Cardiac MR PET CT Program, Boston, MA (United States); University Hospitals Munich, and Ludwig Maximilians University, Department of Clinical Radiology, Munich (Germany); O' Donnell, Christopher J. [Lung and Blood Institute' s Framingham Heart Study, National Heart, Framingham (United States); Fox, Caroline S. [Lung and Blood Institute' s Framingham Heart Study, National Heart, Framingham (United States); Brigham and Women' s Hospital, and Harvard Medical School, Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, Boston, MA (United States)

    2010-07-15

    Measures of left ventricular (LV) mass and dimensions are independent predictors of morbidity and mortality. We determined whether an axial area-based method by computed tomography (CT) provides an accurate estimate of LV mass and volume. A total of 45 subjects (49% female, 56.0 {+-} 12 years) with a wide range of LV geometry underwent contrast-enhanced 64-slice CT. LV mass and volume were derived from 3D data. 2D images were analysed to determine LV area, the direct transverse cardiac diameter (dTCD) and the cardiothoracic ratio (CTR). Furthermore, feasibility was confirmed in 100 Framingham Offspring Cohort subjects. 2D measures of LV area, dTCD and CTR were 47.3 {+-} 8 cm{sup 2}, 14.7 {+-} 1.5 cm and 0.54 {+-} 0.05, respectively. 3D-derived LV volume (end-diastolic) and mass were 148.9 {+-} 45 cm{sup 3} and 124.2 {+-} 34 g, respectively. Excellent inter- and intra-observer agreement were shown for 2D LV area measurements (both intraclass correlation coefficients (ICC) = 0.99, p < 0.0001) and could be confirmed on non-contrast CT. The measured 2D LV area was highly correlated to LV volume, mass and size (r = 0.68; r = 0.73; r = 0.82; all p < 0.0001, respectively). On the other hand, CTR was not correlated to LV volume, mass, size or 2D LV area (all p > 0.27). Compared with traditionally used CTR, LV size can be accurately predicted based on a simple and highly reproducible axial LV area-based measurement. (orig.)

  10. Variabilidade biológica de isolados do Citrus leprosis virus (CiLV oriundos de cultivares de laranjeira Biological variability of Citrus leprosis virus (CiLV isolates from sweet orange cultivars

    Directory of Open Access Journals (Sweden)

    Jadier de Oliveira Cunha Junior

    2007-09-01

    Full Text Available A leprose, causada pelo Citrus leprosis virus (CiLV, é uma das principais doenças presentes em pomares cítricos fluminenses. O objetivo deste trabalho foi comparar o quadro sintomatológico desenvolvido por isolados de CiLV obtidos de cultivares comerciais de laranjeira (Lima, Pêra e Seleta, inoculados mecanicamente em Chenopodium amaranticolor, em três diluições. Após cinco a sete dias da inoculação foram observadas lesões necróticas, com pequeno halo clorótico quando observadas contra a luz. O maior número de lesões, nas três diluições, foi obtido do isolado de 'Seleta', seguido por 'Pêra' e 'Lima'. A melhor diluição utilizada para a observação das lesões foi de 1:10. Os resultados demonstram uma possível variabilidade biológica entre os isolados virais e/ou uma menor ou maior replicação viral, dependendo da cultivar, indicando um possível mecanismo de resistência da planta ao vírus.Citrus leprosis, caused by Citrus leprosis virus (CiLV is one of the major diseases in citrus orchards in the State of Rio de Janeiro. The objective of this study was to compare the development of symptoms on Chenopodium amaranticolor inoculated with CiLV isolates from 'Lima', 'Pera' and 'Seleta' sweet oranges using three different dilutions. Five to seven-days after inoculation, necrotic lesions exhibiting a small chlorotic halo when exposed to the light, were observed. The highest number of lesions developed using the three dilutions was obtained from 'Seleta', an intermediate value from 'Pêra' and the lowest number from 'Lima'. The best dilution for lesions development was 1:10. The results demonstrate a possible biological variability among the virus isolates and/or a lower or higher viral replication, dependent on the cultivar. This indicates a putative mechanism of Citrus resistance to the virus.

  11. A hemocyte-expressed fibrinogen-related protein gene (LvFrep) from the shrimp Litopenaeus vannamei: Expression analysis after microbial infection and during larval development.

    Science.gov (United States)

    Coelho, Jaqueline da Rosa; Barreto, Cairé; Silveira, Amanda da Silva; Vieira, Graziela Cleusa; Rosa, Rafael Diego; Perazzolo, Luciane Maria

    2016-09-01

    Fibrinogen-related proteins (FREPs) comprise a large family of microbial recognition proteins involved in many biological functions in both vertebrate and invertebrate animals. By taking advantage of publicly accessible databases, we have identified a FREP-like homolog in the most cultivated penaeid shrimp, Litopenaeus vannamei (LvFrep). The obtained sequence showed a conserved fibrinogen-related domain (FReD) and displayed significant similarities to FREP-like proteins from other invertebrates and to ficolins from crustaceans. The expression of LvFrep appeared to be limited to circulating hemocytes. Interestingly, LvFrep gene expression was induced in shrimp hemocytes only in response to a Vibrio infection but not to the White spot syndrome virus (WSSV). Moreover, LvFrep transcript levels were detected early in fertilized eggs, suggesting the participation of this immune-related gene in the antimicrobial defenses during shrimp development.

  12. Relationship of basal-septal fibrosis with LV outflow tract obstruction in hypertrophic cardiomyopathy: insights from cardiac magnetic resonance analysis.

    Science.gov (United States)

    Nakamura, Takashi; Iwanaga, Yoshitaka; Yasuda, Masakazu; Kawamura, Takayuki; Miyaji, Yuki; Morooka, Hanako; Miyazaki, Shunichi

    2016-04-01

    Myocardial fibrosis is frequently observed and may be associated with the prognosis in patients with hypertrophic cardiomyopathy (HCM); however, the clinical pathophysiological features, particularly in terms of fibrosis, of hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. This study aimed to determine a role of local fibrosis in HOCM using cardiac magnetic resonance (CMR). 108 consecutive HCM patients underwent CMR. HOCM was defined as a left ventricular outflow tract (LVOT) pressure gradient ≥30 mmHg at rest. Myocardial mass and fibrosis mass by late gadolinium-enhancement CMR (LGE-CMR) were calculated and the distribution/pattern was analyzed using the AHA 17-segment model. LV ejection fraction (LVEF) was significantly higher in patients with HOCM (n = 19) than in those with nonobstructive HCM (n = 89) (P < 0.05). Both total myocardial and fibrosis masses in LV were similar in the two groups (P = 0.385 and P = 0.859, respectively). However, fibrosis in the basal septum was significantly less frequent in the HOCM group than in the nonobstructive HCM group (P < 0.01). The LVOT pressure gradient was significantly higher in the basal-septal non-fibrosis group than in the fibrosis group (23.6 ± 37.3 vs. 4.8 ± 11.4 mmHg, P < 0.01). Multivariate analysis revealed that basal-septal fibrosis was an independent negative predictor of LVOT obstruction in addition to the local wall thickness and LVEF as positive predictors in HCM patients. In conclusion, a significant association was observed between LVOT obstruction and basal septal fibrosis by LGE-CMR in HCM patients. In addition to negative impact of basal-septal fibrosis, basal-septal hypertrophy and preserved global LV contractility may be associated with the pathophysiological features of LVOT obstruction.

  13. Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial

    Science.gov (United States)

    Cassidy, J; Douillard, J-Y; Twelves, C; McKendrick, J J; Scheithauer, W; Bustová, I; Johnston, P G; Lesniewski-Kmak, K; Jelic, S; Fountzilas, G; Coxon, F; Díaz-Rubio, E; Maughan, T S; Malzyner, A; Bertetto, O; Beham, A; Figer, A; Dufour, P; Patel, K K; Cowell, W; Garrison, L P

    2006-01-01

    Oral capecitabine (Xeloda®) is an effective drug with favourable safety in adjuvant and metastatic colorectal cancer. Oxaliplatin-based therapy is becoming standard for Dukes' C colon cancer in patients suitable for combination therapy, but is not yet approved by the UK National Institute for Health and Clinical Excellence (NICE) in the adjuvant setting. Adjuvant capecitabine is at least as effective as 5-fluorouracil/leucovorin (5-FU/LV), with significant superiority in relapse-free survival and a trend towards improved disease-free and overall survival. We assessed the cost-effectiveness of adjuvant capecitabine from payer (UK National Health Service (NHS)) and societal perspectives. We used clinical trial data and published sources to estimate incremental direct and societal costs and gains in quality-adjusted life months (QALMs). Acquisition costs were higher for capecitabine than 5-FU/LV, but higher 5-FU/LV administration costs resulted in 57% lower chemotherapy costs for capecitabine. Capecitabine vs 5-FU/LV-associated adverse events required fewer medications and hospitalisations (cost savings £3653). Societal costs, including patient travel/time costs, were reduced by >75% with capecitabine vs 5-FU/LV (cost savings £1318), with lifetime gain in QALMs of 9 months. Medical resource utilisation is significantly decreased with capecitabine vs 5-FU/LV, with cost savings to the NHS and society. Capecitabine is also projected to increase life expectancy vs 5-FU/LV. Cost savings and better outcomes make capecitabine a preferred adjuvant therapy for Dukes' C colon cancer. This pharmacoeconomic analysis strongly supports replacing 5-FU/LV with capecitabine in the adjuvant treatment of colon cancer in the UK. PMID:16622438

  14. LV reverse remodeling imparted by aortic valve replacement for severe aortic stenosis; is it durable? A cardiovascular MRI study sponsored by the American Heart Association

    Directory of Open Access Journals (Sweden)

    Caruppannan Ketheswaram

    2011-04-01

    Full Text Available Abstract Background In patients with severe aortic stenosis (AS, long-term data tracking surgically induced effects of afterload reduction on reverse LV remodeling are not available. Echocardiographic data is available short term, but in limited fashion beyond one year. Cardiovascular MRI (CMR offers the ability to serially track changes in LV metrics with small numbers due to its inherent high spatial resolution and low variability. Hypothesis We hypothesize that changes in LV structure and function following aortic valve replacement (AVR are detectable by CMR and once triggered by AVR, continue for an extended period. Methods Tweny-four patients of which ten (67 ± 12 years, 6 female with severe, but compensated AS underwent CMR pre-AVR, 6 months, 1 year and up to 4 years post-AVR. 3D LV mass index, volumetrics, LV geometry, and EF were measured. Results All patients survived AVR and underwent CMR 4 serial CMR's. LVMI markedly decreased by 6 months (157 ± 42 to 134 ± 32 g/m2, p 2. Similarly, EF increased pre to post-AVR (55 ± 22 to 65 ± 11%,(p 2. LV stroke volume increased rapidly from pre to post-AVR (40 ± 11 to 44 ± 7 ml, p Conclusion After initial beneficial effects imparted by AVR in severe AS patients, there are, as expected, marked improvements in LV reverse remodeling. Via CMR, surgically induced benefits to LV structure and function are durable and, unexpectedly express continued, albeit markedly incomplete improvement through 4 years post-AVR concordant with sustained improved clinical status. This supports down-regulation of both mRNA and MMP activity acutely with robust suppression long term.

  15. A Scenario-Based Approach for Energy Storage Capacity Determination in LV Grids with High PV Penetration

    DEFF Research Database (Denmark)

    Hashemi Toghroljerdi, Seyedmostafa; Østergaard, Jacob; Yang, Guangya

    2014-01-01

    In this paper a new method is proposed to determine the minimum energy storage required to be installed at different locations of a low voltage (LV) grid in order to prevent the overvoltage due to high residential photovoltaic (PV) penetration. The method is based on the voltage sensitivity...... with different occurrence probabilities without involving the time-series studies problems. The proposed method is capable of modeling output power of PV panels with different orientations as well as different electric vehicle (EV) charging patterns....

  16. Innovation in Cable Outgoing Pattern of LV Cabinets%低压柜电缆出线方式创新

    Institute of Scientific and Technical Information of China (English)

    申景阳

    2015-01-01

    老山自行车馆工程低压柜为上出线方式,低压柜的出线电缆放置在两层1 000 mm × 200 mm的桥架中, 由于出线回路复杂, 上下层桥架中的电缆存在进入同一面低压柜的情况, 特别是1AA1~1AA7, 2AA1~2AA7两列低压柜中集中了场馆近90%的用电负荷, 共需配出百余条供电电缆. 两层配电桥架的设计不可能合理安装上下交错的电缆. 通过自主创新和方案策划, 设计并实施了柜顶配线箱, 有效地解决了低压柜上出线的各种问题, 保证了安装质量和观感效果.%The LV cabinets of Laoshan Velodrome Project are characterized by upper cables outgoing, which are arranged between two layers of 1 000 mm × 200 mm bridging structure. The loop of the outgoing cables is complex, the cable in the upper layer of the bridging structure and that in the lower layer enter the same LV cabinet, and especially 90 % of the electrical loads of Laoshan Velodrome is concentrated in 1AA1~1AA7 and 2AA1~2AA7 LV cabinets, so hundreds of power supply cables are required. The design of two-layer power distribution bridging structure is unable to realize reasonable installation of the cables staggered up and down. Through independent innovation and program planning, a cable distribution box is designed to arrange on the cabinet top to effectively solve various problems caused by upper cables outgoing of LV cabinets and guarantee the installation quality and appearance effect.

  17. Application of a fast and efficient algorithm to detect areas with prerequisites for landslide in sensitive clays, Göta Älv, Sweden

    Science.gov (United States)

    Melchiorre, Caterina; Tryggvason, Ari

    2014-05-01

    In Sweden, landslide stability maps are based on the recognition of topographical and soil conditions. The topographical criterion is based on the ratio between height of the slope and its length. The calculation of this cross-sectional angle is straight forward in one dimension, but slightly more complicated in two dimensions and very computationally expensive in a GIS environment. We present an application of a fast and efficient computer algorithm based on slope and soil criteria in Göta Älv, southwest Sweden. The algorithm, compared to other software implementations of the cross-sectional angle criterion, guarantees a fast execution, the possibility to insert several threshold values of the cross-sectional angle and the use of information on bedrock elevation. As input maps we used a 1:50000 Quaternary soil map, a DEM at 2x2 m pixel resolution, and a bedrock elevation map. We used two sets of cross-sectional angle thresholds, the first one derived from stability calculation and the second one assessed through the relationship between QCSI (i.e., estimated value of the sensitivity) and the cross-sectional angle calculated from the landslide scar database. A comparison between the results of the algorithm using or not using the bedrock information was also performed. The produced maps were validated by using the landslide scar database and a hazard map. The results show that the use of bedrock information decreases the calculated areas with prerequisites for landslides, whereas not decreasing the performance of the algorithm. The maps produced by using the two different sets of cross-angle thresholds are very similar and show similar results in the validation. This means that it would be possible to extent this methodology in areas without geotechnical information by using less expensive data such as the QCSI. Moreover, the use of several cross-sectional angle thresholds is not possible in other software implementations available at the moment. This means that

  18. Verbālās metaforas ziņu valodā Latvijas ziņās (ziņu portālos apollo.lv un delfi.lv: 2010–2012)

    OpenAIRE

    Puriņa, Krista

    2013-01-01

    Bakalaura darba „Verbālās metaforas ziņu valodā Latvijas ziņās (ziņu portālos apollo.lv un delfi.lv: 2010–2012)” mērķis ir parādīt, ka ziņu valodā ir daudz metaforas, kuras padara interesantāku vēstījumu, ietekmē tā efektivitāti. Pētnieciskā problēma ir: 1) noskaidrot, vai ziņu valodā ir sastopamas metaforas, 2) kādas, 3) vai to vēstījums nevar tikt uztverts kļūdaini, 4) kas ir vēstījuma efektivitātes pamatā? Teorētiskajā daļā – valoda, semiotika, ziņas, preses relīzes, metaforas Leiko...

  19. Study on the Fermentation Conditions of a Mucopolysaccharide-producing Bacterium LV-1%一株粘性多糖产生菌LV-1的发酵条件研究

    Institute of Scientific and Technical Information of China (English)

    梁玉丽; 郭继强; 陈晓艺; 刘志文; 李宪臻

    2009-01-01

    [Objective] The fermentation conditions of a mucopolysaccharide-producing bacterium LV-1 which isolated from soil sample were studied.[Method] The polysaccharide-producing bacterium was isolated by serial dilution method, the effects of carbon source, nitrogen source, the initial pH and temperature on producing polysaccharide by it were discussed to confirm the optimum fermentation conditions.[Result] The physicochemical properties showed that the polysaccharide was water-soluble, but insoluble in organic solvents including ethanol, butanol, and chloroform.It was neutral polysaccharide with negative charge and without reducing terminal. The pH of its solution was pH=7.5. There were no protein, fructose, uronic acid, sulphate and starch-like structure included in polysaccharide molecules. The optimum fermentation conditions for polysaccharide production were 3% mannitol as carbon source, 0.25% yeast extract as nitrogen source, culture temperature 28 ℃ and pH=7.5. [Conclusion] The research could provie basis for development and utilization of LV-1 and industrialized production of mucopolysaccharide.

  20. Interneta sociālie tīkli draugiem.lv, mammam/tetiem.lv un twitter.com kā reklāmas nesēji Latvijā (2009.gads)

    OpenAIRE

    2010-01-01

    Maģistra darba tēma ir „Interneta sociālie tīkli draugiem.lv, mammam/tetiem.lv un twitter.com kā reklāmas nesēji Latvijā (2009.gads)”. Darba mērķis ir izpētīt Latvijas interneta sociālo tīklu vidi kā potenciāli augošu un reklāmai piemērotu, kā arī izpētīt pamanāmākos reklāmas gadījumus šajos portālos. Teorijas daļā tiek apskatīta Web 2.0 ēra, interneta reklāmas un sociālo mediju mārketinga īpatnības, sociālo tīklu fenomens un teorijas, Latvijas reklāmas tirgus un auditorija, kā arī sociāl...

  1. Litopenaeus vannamei sterile-alpha and armadillo motif containing protein (LvSARM is involved in regulation of Penaeidins and antilipopolysaccharide factors.

    Directory of Open Access Journals (Sweden)

    Pei-Hui Wang

    Full Text Available The Toll-like receptor (TLR-mediated NF-κB pathway is tightly controlled because overactivation may result in severe damage to the host, such as in the case of chronic inflammatory diseases and cancer. In mammals, sterile-alpha and armadillo motif-containing protein (SARM plays an important role in negatively regulating this pathway. While Caenorhabditis elegans SARM is crucial for an efficient immune response against bacterial and fungal infections, it is still unknown whether Drosophila SARM participates in immune responses. Here, Litopenaeus vannamei SARM (LvSARM was cloned and functionally characterized. LvSARM shared signature domains with and exhibited significant similarities to mammalian SARM. Real-time quantitative PCR analysis indicated that the expression of LvSARM was responsive to Vibrio alginolyticus and white spot syndrome virus (WSSV infections in the hemocyte, gill, hepatopancreas and intestine. In Drosophila S2 cells, LvSARM was widely distributed in the cytoplasm and could significantly inhibit the promoters of the NF-κB pathway-controlled antimicrobial peptide genes (AMPs. Silencing of LvSARM using dsRNA-mediated RNA interference increased the expression levels of Penaeidins and antilipopolysaccharide factors, which are L.vannamei AMPs, and increased the mortality rate after V. alginolyticus infection. Taken together, our results reveal that LvSARM may be a novel component of the shrimp Toll pathway that negatively regulates shrimp AMPs, particularly Penaeidins and antilipopolysaccharide factors.

  2. Litopenaeus vannamei sterile-alpha and armadillo motif containing protein (LvSARM) is involved in regulation of Penaeidins and antilipopolysaccharide factors.

    Science.gov (United States)

    Wang, Pei-Hui; Gu, Zhi-Hua; Wan, Ding-Hui; Zhu, Wei-Bin; Qiu, Wei; Weng, Shao-Ping; Yu, Xiao-Qiang; He, Jian-Guo

    2013-01-01

    The Toll-like receptor (TLR)-mediated NF-κB pathway is tightly controlled because overactivation may result in severe damage to the host, such as in the case of chronic inflammatory diseases and cancer. In mammals, sterile-alpha and armadillo motif-containing protein (SARM) plays an important role in negatively regulating this pathway. While Caenorhabditis elegans SARM is crucial for an efficient immune response against bacterial and fungal infections, it is still unknown whether Drosophila SARM participates in immune responses. Here, Litopenaeus vannamei SARM (LvSARM) was cloned and functionally characterized. LvSARM shared signature domains with and exhibited significant similarities to mammalian SARM. Real-time quantitative PCR analysis indicated that the expression of LvSARM was responsive to Vibrio alginolyticus and white spot syndrome virus (WSSV) infections in the hemocyte, gill, hepatopancreas and intestine. In Drosophila S2 cells, LvSARM was widely distributed in the cytoplasm and could significantly inhibit the promoters of the NF-κB pathway-controlled antimicrobial peptide genes (AMPs). Silencing of LvSARM using dsRNA-mediated RNA interference increased the expression levels of Penaeidins and antilipopolysaccharide factors, which are L.vannamei AMPs, and increased the mortality rate after V. alginolyticus infection. Taken together, our results reveal that LvSARM may be a novel component of the shrimp Toll pathway that negatively regulates shrimp AMPs, particularly Penaeidins and antilipopolysaccharide factors.

  3. Selective Attention to Perceptual Dimensions and Switching between Dimensions

    Science.gov (United States)

    Meiran, Nachshon; Dimov, Eduard; Ganel, Tzvi

    2013-01-01

    In the present experiments, the question being addressed was whether switching attention between perceptual dimensions and selective attention to dimensions are processes that compete over a common resource? Attention to perceptual dimensions is usually studied by requiring participants to ignore a never-relevant dimension. Selection failure…

  4. Cultural dimensions and innovation

    Directory of Open Access Journals (Sweden)

    Anna Strychalska-Rudzewicz

    2015-11-01

    Full Text Available This paper examines the effect of culture’s dimensions on national innovation index. The results of Pearson correlation coefficient between culture dimensions and the Global Innovation Index (GII are very similar to the results obtained in the case of Summary Innovation Index (SII in European countries. The strong negative correlation was observed in the case of power distance and uncertainty avoidance whereas individualism has a positive effect on innovation index. The results suggest that low power distance and uncertainty-accepting countries may be more innovative than high power distance and uncertainty-avoiding societies.

  5. Interaction between endoplasmic reticulum stress and caspase 8 activation in retrovirus MoMuLV-ts1-infected astrocytes.

    Science.gov (United States)

    Liu, Na; Scofield, Virginia L; Qiang, Wenan; Yan, Mingshan; Kuang, Xianghong; Wong, Paul K Y

    2006-05-10

    The murine retrovirus, MoMuLV-ts1, induces progressive paralysis and immune deficiency in FVB/N mice. We have reported previously that ts1 infection causes apoptosis in astrocytes via endoplasmic reticulum (ER) and mitochondrial stress (Liu, N., Kuang, X., Kim, H.T., Stoica, G., Qiang, W., Scofield, V.L., Wong, P.K.Y. Wong. 2004. Possible involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in MoMuLV-ts1-induced apoptosis in astrocytes. J. NeuroVirol. 10, 189-198). In the present study, we show that caspase 8 activation in these cells is mediated through ER stress-associated elevation of death receptor DR5 and the C/EBP homologous protein (GADD153/CHOP), an ER stress-initiated transcription factor, rather than through TNFalpha and TNF-R1 interactions on the cell surface. Treatment with Z-IETD-FMK, a specific inhibitor of caspase 8 enzymatic activity, reduced ER stress by two mechanisms: by inhibiting caspase 8 activation, and by preventing cleavage of the ER-associated membrane protein BAP31 into BAP20, which exacerbates the ER stress response. These findings suggest that caspase 8- and ER stress-associated apoptotic pathways are linked in ts1-infected astrocytes.

  6. Clinical Characteristics and Outcomes of Patients with Amphetamine-Associated Cardiomyopathy in South Auckland, New Zealand.

    Science.gov (United States)

    Kueh, Shaw-Hua Anthony; Gabriel, Ruvin S; Lund, Mayanna; Sutton, Tim; Bradley, Joshua; Kerr, Andrew J; Looi, Jen-Li

    2016-11-01

    Amphetamine-associated cardiomyopathy (AAC) is becoming an increasingly recognised entity. The characteristics and outcomes of these patients are poorly understood. Thirty patients admitted with heart failure and echocardiographic evidence of cardiomyopathy between 2005 and 2014 and who had a documented history of amphetamine abuse that was considered an important factor in the causation of their cardiomyopathy were retrospectively identified. Mean age at presentation was 40±10 years with a male predominance (n=25, 83%). The majority were of indigenous Maori ethnicity. At presentation, four patients were in cardiogenic shock. Five patients required intensive care unit (ICU) admission for inotropic support and mechanical ventilation. Fifteen had severe left ventricular (LV) dilation (mean LV end-diastolic dimension 6.8±1.0cm) and all patients had severe LV dysfunction (mean LV ejection fraction 22±8%). Despite optimal heart failure therapy, LV size remained significantly dilated with minimal improvement in LV function. During median follow-up of 18 months, five patients died from end-stage heart failure and 17 had at least one readmission with decompensated heart failure. Amphetamine-associated cardiomyopathy was seen predominantly in young indigenous Maori men. They presented with severe cardiomyopathy, often requiring ICU admission. Severe LV dilation and significant LV dysfunction persisted despite treatment and mortality was high. Copyright © 2016 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.

  7. Method card design dimensions

    DEFF Research Database (Denmark)

    Wölfel, Christiane; Merritt, T.

    2013-01-01

    . The card-based tools are explained in terms of five design dimensions including the intended purpose and scope of use, duration of use, methodology, customization, and formal/material qualities. Our analysis suggests three design patterns or archetypes for existing card-based design method tools...

  8. Dimensions of trust

    DEFF Research Database (Denmark)

    Frederiksen, Morten

    2012-01-01

    in scope and mode influenced by the intersecting dimensions of relations, objects and situations. Furthermore, trust exists between an outer threshold of expected deceit and an inner threshold of confident reliance. The findings from the qualitative study contribute new knowledge on the diversity of trust...

  9. Atrial Remodeling Is Directly Related to End-Diastolic Left Ventricular Pressure in a Mouse Model of Ventricular Pressure Overload

    NARCIS (Netherlands)

    De Jong, Anne Margreet; Van Gelder, Isabelle C.; Baudoin, Inge; Cannon, Megan V.; Van Gilst, Wiek H.; Maass, Alexander H.

    2013-01-01

    Background: Atrial fibrillation (AF) is often preceded by underlying cardiac diseases causing ventricular pressure overload. Objective: It was our aim to investigate the progression of atrial remodeling in a small animal model of ventricular pressure overload and its association with induction of

  10. Peat Biomass Smoke Particle Exposure in Rats Decreases Expiratory Time and Increases Left Heart End Diastolic Volume

    Science.gov (United States)

    Wildland fires, favored by prolonged drought and rising temperatures, generate significant amounts of ambient particulate matter (PM), which has been linked to adverse health outcomes. The eastern North Carolina peat fires of Pocosin Lake in 2008 and Pains Bay in 2011 were some o...

  11. Serological survey of Toxoplasma gondii, Dirofilaria immitis, Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) infections in pet cats in Bangkok and vicinities, Thailand.

    Science.gov (United States)

    Sukhumavasi, Woraporn; Bellosa, Mary L; Lucio-Forster, Araceli; Liotta, Janice L; Lee, Alice C Y; Pornmingmas, Pitcha; Chungpivat, Sudchit; Mohammed, Hussni O; Lorentzen, Leif; Dubey, J P; Bowman, Dwight D

    2012-08-13

    The seroprevalence of Toxoplasma gondii, Dirofilaria immitis (heartworm), feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) infections was examined using serum or plasma samples from 746 pet cats collected between May and July 2009 from clinics and hospitals located in and around Bangkok, Thailand. The samples were tested for heartworm, FIV, and FeLV using a commercial ELISA. Of the 746 samples, 4.6% (34/746) were positive for heartworm antigen, 24.5% (183/746) had circulating FeLV antigen, and 20.1% (150/746) had antibodies against FIV. In addition, the first 348 submitted samples were tested for T. gondii antibodies using a modified agglutination test (MAT, cut off 1:25); 10.1% (35/348) were seropositive. Of the 348 cats sampled for all four pathogens, 11, 10, and 1 were positive for T. gondii antibodies and FIV antibodies, FeLV antigen, or D. immitis antigen, respectively. Of the 35 T. gondii-seropositive cats, 42.9% (15/35) were co-infected with at least one of the other three pathogens. The presence of antibodies to FIV was significantly associated with both age and gender, while FeLV antigen presence was only associated with age. In the case of FIV, males were twice as likely to be infected as females, and cats over 10 years of age were 13.5 times more likely to be infected than cats less than 1 year of age. FeLV antigen was more common in younger cats, with cats over 10 years of age being 10 times less likely to be FeLV positive than cats under 1 year of age. This is the first survey for these four pathogens affecting feline health in Thailand.

  12. Epicardial adipose tissue in patients with heart failure

    Directory of Open Access Journals (Sweden)

    Michaely Henrik

    2010-07-01

    Full Text Available Abstract Purpose The aim of this study was to evaluate the extent of epicardial adipose tissue (EAT and its relationship with left ventricular (LV parameters assessed by cardiovascular magnetic resonance (CMR in patients with congestive heart failure (CHF and healthy controls. Background EAT is the true visceral fat deposited around the heart which generates various bioactive molecules. Previous studies found that EAT is related to left ventricular mass (LVM in healthy subjects. Further studies showed a constant EAT to myocardial mass ratio in normal, ischemic and hypertrophied hearts. Methods CMR was performed in 66 patients with CHF due to ischemic cardiomyopathy (ICM, or dilated cardiomyopathy (DCM and 32 healthy controls. Ventricular volumes, dimensions and LV function were assessed. The amount of EAT was determined volumetrically and expressed as mass indexed to body surface area. Additionally, the EAT/LVM and the EAT/left ventricular remodelling index (LVRI ratios were calculated. Results Patients with CHF had less indexed EAT mass than controls (22 ± 5 g/m2 versus 34 ± 4 g/m2, p 2 versus 23 ± 6 g/m2, p = 0.14. Linear regression analysis showed that with increasing LV end-diastolic diameter (LV-EDD (r = 0.42, p = 0.0004 and LV end-diastolic mass (LV-EDM (r = 0.59, p Conclusion Patients with CHF revealed significantly reduced amounts of EAT. An increase in LVM is significantly related to an increase in EAT in both patients with CHF and controls. However, different from previous reports the EAT/LVEDM-ratio in patients with CHF was significantly reduced compared to healthy controls. Furthermore, the LV function correlated best with the indexed EAT/LVRI ratio in CHF patients. Metabolic abnormalities and/or anatomic alterations due to disturbed cardiac function and geometry seem to play a key role and are a possible explanation for these findings.

  13. Cosmology With Extra Dimensions

    CERN Document Server

    Martín, J

    2005-01-01

    We review several properties of models that include extra dimensions, focusing on aspects related to cosmology and particle physics phenomenology. The properties of effective four dimensional inflationary geometry are studied in two distinct frameworks: (i) in Kaluza- Klein (KK) compactifications and (ii) in braneworld scenarios. From numerical simulations we find that inflationary braneworlds are unstable if the scale of inflation is too large in comparison with the stabilization scale of the interbrane distance. The analysis of perturbations confirms the existence of a tachyon associated with the volume modulus of the extra dimensions both in braneworlds and KK compactifications. With the numerical program BRANECODE non- perturbative properties of braneworlds are studied. We fully understand the non-perturbative consequences of this instability. Generic attractors are (i) an increase of the interbrane distance and the formation of a naked singularity, (ii) the brane colli...

  14. Cultural dimensions of learning

    Science.gov (United States)

    Eyford, Glen A.

    1990-06-01

    How, what, when and where we learn is frequently discussed, as are content versus process, or right brain versus left brain learning. What is usually missing is the cultural dimension. This is not an easy concept to define, but various aspects can be identified. The World Decade for Cultural Development emphasizes the need for a counterbalance to a quantitative, economic approach. In the last century poets also warned against brutalizing materialism, and Sorokin and others have described culture more recently in terms of cohesive basic values expressed through aesthetics and institutions. Bloom's taxonomy incorporates the category of affective learning, which internalizes values. If cultural learning goes beyond knowledge acquisition, perhaps the surest way of understanding the cultural dimension of learning is to examine the aesthetic experience. This can use myths, metaphors and symbols, and to teach and learn by using these can help to unlock the human potential for vision and creativity.

  15. Introduction to Extra Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Rizzo, Thomas G.; /SLAC

    2010-04-29

    Extra dimensions provide a very useful tool in addressing a number of the fundamental problems faced by the Standard Model. The following provides a very basic introduction to this very broad subject area as given at the VIII School of the Gravitational and Mathematical Physics Division of the Mexican Physical Society in December 2009. Some prospects for extra dimensional searches at the 7 TeV LHC with {approx}1 fb{sup -1} of integrated luminosity are provided.

  16. The Regional Dimension

    DEFF Research Database (Denmark)

    Eskjær, Mikkel Fugl

    2013-01-01

    is largely dependent on regional media systems, yet the role this regional dimension plays has been largely overlooked. This article presents a comparative study of climate-change coverage in three geo-cultural regions, The Middle East, Scandinavia, and North America, and explores the link between global...... climate-change communication and regional media systems. It finds that regional variations in climate-change communication carry important communicative implications concerning perceptions of climate change's relevance and urgency...

  17. No Evidence of XMRV or MuLV Sequences in Prostate Cancer, Diffuse Large B-Cell Lymphoma, or the UK Blood Donor Population

    Directory of Open Access Journals (Sweden)

    Mark James Robinson

    2011-01-01

    Full Text Available Xenotropic murine leukaemia virus-related virus (XMRV is a recently described retrovirus which has been claimed to infect humans and cause associated pathology. Initially identified in the US in patients with prostate cancer and subsequently in patients with chronic fatigue syndrome, doubt now exists that XMRV is a human pathogen. We studied the prevalence of genetic sequences of XMRV and related MuLV sequences in human prostate cancer, from B cell lymphoma patients and from UK blood donors. Nucleic acid was extracted from fresh prostate tissue biopsies, formalin-fixed paraffin-embedded (FFPE prostate tissue and FFPE B-cell lymphoma. The presence of XMRV-specific LTR or MuLV generic gag-like sequences was investigated by nested PCR. To control for mouse DNA contamination, a PCR that detected intracisternal A-type particle (IAP sequences was included. In addition, DNA and RNA were extracted from whole blood taken from UK blood donors and screened for XMRV sequences by real-time PCR. XMRV or MuLV-like sequences were not amplified from tissue samples. Occasionally MuLV gag and XMRV-LTR sequences were amplified from Indian prostate cancer samples, but were always detected in conjunction with contaminating murine genomic DNA. We found no evidence of XMRV or MuLV infection in the UK blood donors.

  18. The Mus cervicolor MuLV isolate M813 is highly fusogenic and induces a T-cell lymphoma associated with large multinucleated cells.

    Science.gov (United States)

    Prassolov, V; Ivanov, D; Hein, S; Rutter, G; Münk, C; Löhler, J; Stocking, C

    2001-11-10

    M813 is a type-C murine leukemia virus (MuLV) isolated from the Asian rodent Mus cervicolor. We have recently demonstrated that M813 defines a distinct MuLV receptor interference group. Here we show that M813 rapidly induces fusion of MuLV-expressing fibroblasts from "without," with syncytia being observed within 1 h after exposure to virus. Infection of fibroblasts with MuLV from all tested receptor-interference groups imparts susceptibility to M813-induced fusion, provided the cells also express the M813 receptor. Syncytium induction is also observed in vivo; mice infected with M813 develop a peripheral T-cell lymphoma, which is associated with large multinucleated cells of macrophage origin. A recombinant Moloney MuLV/M813 chimeric virus demonstrated that syncytium induction is a function of the Env SU protein. We postulate that the highly fusogenic property of M813 is attributable to either its unique receptor usage or sequences in the proline-rich domain of the Env protein.

  19. Alexa Fluor 546-ArIB[V11L;V16A] is a potent ligand for selectively labeling alpha 7 nicotinic acetylcholine receptors.

    Science.gov (United States)

    Hone, Arik J; Whiteaker, Paul; Mohn, Jesse L; Jacob, Michele H; McIntosh, J Michael

    2010-08-01

    The alpha7* (*denotes the possible presence of additional subunits) nicotinic acetylcholine receptor (nAChR) subtype is widely expressed in the vertebrate nervous system and implicated in neuropsychiatric disorders that compromise thought and cognition. In this report, we demonstrate that the recently developed fluorescent ligand Cy3-ArIB[V11L;V16A] labels alpha7 nAChRs in cultured hippocampal neurons. However, photobleaching of this ligand during long image acquisition times prompted us to develop a new derivative. In photostability studies, this new ligand, Alexa Fluor 546-ArIB[V11L;V16A], was significantly more resistant to bleaching than the Cy3 derivative. The classic alpha7 ligand alpha-bungarotoxin binds to alpha1* and alpha9* nAChRs. In contrast, Alexa Fluor 546-ArIB[V11L;V16A] potently (IC(50) 1.8 nM) and selectively blocked alpha7 nAChRs but not alpha1* or alpha9* nAChRs expressed in Xenopus oocytes. Selectivity was further confirmed by competition binding studies of native nAChRs in rat brain membranes. The fluorescence properties of Alexa Fluor 546-ArIB[V11L;V16A] were assessed using human embryonic kidney-293 cells stably transfected with nAChRs; labeling was observed on cells expressing alpha7 but not cells expressing alpha3beta2, alpha3beta4, or alpha4beta2 nAChRs. Further imaging studies demonstrate that Alexa Fluor 546-ArIB[V11L;V16A] labels hippocampal neurons from wild-type mice but not from nAChR alpha7 subunit-null mice. Thus, Alexa Fluor 546-ArIB[V11L;V16A] represents a potent and selective ligand for imaging alpha7 nAChRs.

  20. Public Value Dimensions

    DEFF Research Database (Denmark)

    Andersen, lotte bøgh; Beck Jørgensen, Torben; Kjeldsen, Anne-Mette

    2012-01-01

    Further integration of the public value literature with other strands of literature within Public Administration necessitates a more specific classification of public values. This paper applies a typology linked to organizational design principles, because this is useful for empirical public...... administration studies. Based on an existing typology of modes of governance, we develop a classification and test it empirically, using survey data from a study of the values of 501 public managers. We distinguish between seven value dimensions (the public at large, rule abidance, societal interests, budget...... the integration between the public value literature and other parts of the Public Administration discipline....

  1. Adjoint Functors and Representation Dimensions

    Institute of Scientific and Technical Information of China (English)

    Chang Chang XI

    2006-01-01

    We study the global dimensions of the coherent functors over two categories that are linked by a pair of adjoint functors. This idea is then exploited to compare the representation dimensions of two algebras. In particular, we show that if an Artin algebra is switched from the other, then they have the same representation dimension.

  2. Ambulatory blood pressure and echocardiographic left ventricular dimensions in elderly hypertensive subjects.

    Science.gov (United States)

    Rizzo, V; Piccirillo, G; Cicconetti, P; Bianchi, A; Capponi, L; Salza, M C; Cacciafesta, M; Marigliano, V

    1996-10-01

    In a consecutive series of 62 hypertensive elderly subjects, the authors studied the relation of blood pressure circadian variations with echocardiographic parameters of left ventricular (LV) hypertrophy. All the subjects were submitted to an ambulatory blood pressure monitoring (ABPM) and to B- and M-mode echocardiography. In the elderly hypertensive group, LV mass index (LVMI) was more strongly related to twenty-four-hour, daytime and nighttime systolic ambulatory blood pressure (r = 0.52, r = 0.37, r = 0.51) than diastolic ambulatory blood pressures were (r = 0.32, r = 0.18, r = 0.33). Casual systolic and diastolic blood pressure (CBP) was found more weakly related to LVMI than ambulatory blood pressures were (r = 0.35, r = 0.26). Elderly hypertensive subjects were divided into two subgroups in relation to the presence (group 1) or absence (group 2) of blood pressure nocturnal decline. No differences were found between these two subgroups in regard to: casual blood pressure values, ambulatory blood pressures in the diurnal period, sex, body surface area, height, weight, and age. LVMIs were computed in all three groups and showed the following results: 89.32 +/- 19.76 in elderly normotensives, 91.21 +/- 31.32 in group 1, and 99.80 +/- 18.21 in group 2. Echocardiographic parameters of LV dimensions and LVMIs were different in group 1 and 2. An inverse correlation, statistically significant, was observed between LVMIs and the nocturnal blood pressure reduction (systolic: r = -0.36, P < 0.05; diastolic: r = -0.29, P < 0.05). These results suggest an association between a smaller LV mass and nocturnal blood pressure decline in elderly hypertensive patients.

  3. Urban Screen and Spatial Dimension

    Directory of Open Access Journals (Sweden)

    Litta Primasari

    2013-11-01

    Full Text Available This paper is discussing about the urban screen phenomena and its influence to spatial dimension in urban space. The visual characteristics which are forming a spatial dimension will be an emphasis to be presented. Urban screen as a visual intervention has an impact to spatial configuration in urban space. The space dimension was not dominated with materiality limitation, but also images. We have to consider that people senses can measure a spatial dimension, knowing as a perception. That is a human visual and mind relation. The spatial dimension has no longer tangible boundary, but also has intangible ones. Spatial dimension in urban screens phenomena is not merely mathematics, nor spatial dimension in physics which are based on a three-dimensional Cartesian coordinate system. Movement can be expressed in other terms, by how far we can move depends on our eyes to catch that space limitation, and how fast we can move is depends on our mind to perceive some visual phenomenon, that is a spatial dimension. So, the dimension will depend on a visual quality that we perceived. The movement of the body and people’s thought will be an important term to generate the space dimension in urban screen phenomenon. The activity of body’s movement and thought will influence the depth of space dimension.

  4. Correlation dimension of financial market

    Science.gov (United States)

    Nie, Chun-Xiao

    2017-05-01

    In this paper, correlation dimension is applied to financial data analysis. We calculate the correlation dimensions of some real market data and find that the dimensions are significantly smaller than those of the simulation data based on geometric Brownian motion. Based on the analysis of the Chinese and US stock market data, the main results are as follows. First, by calculating three data sets for the Chinese and US market, we find that large market volatility leads to a significant decrease in the dimensions. Second, based on 5-min stock price data, we find that the Chinese market dimension is significantly larger than the US market; this shows a significant difference between the two markets for high frequency data. Third, we randomly extract stocks from a stock set and calculate the correlation dimensions, and find that the average value of these dimensions is close to the dimension of the original set. In addition, we analyse the intuitional meaning of the relevant dimensions used in this paper, which are directly related to the average degree of the financial threshold network. The dimension measures the speed of the average degree that varies with the threshold value. A smaller dimension means that the rate of change is slower.

  5. Unification in One Dimension

    CERN Document Server

    Jackson, David J

    2016-01-01

    A physical theory of the world is presented under the unifying principle that all of nature is laid out before us and experienced through the passage of time. The one-dimensional progression in time is opened out into a multi-dimensional mathematically consistent flow, with the simplicity of the former giving rise to symmetries of the latter. The act of perception identifies an extended spacetime arena of intermediate dimension, incorporating the symmetry of geometric spatial rotations, against which physical objects are formed and observed. The spacetime symmetry is contained as a subgroup of, and provides a natural breaking mechanism for, the higher general symmetry of time. It will be described how the world of gravitation and cosmology, as well as quantum theory and particle physics, arises from these considerations.

  6. Method card design dimensions

    DEFF Research Database (Denmark)

    Wölfel, Christiane; Merritt, T.

    2013-01-01

    . The card-based tools are explained in terms of five design dimensions including the intended purpose and scope of use, duration of use, methodology, customization, and formal/material qualities. Our analysis suggests three design patterns or archetypes for existing card-based design method tools...... and highlights unexplored areas in the design space. The paper concludes with recommendations for the future development of card-based methods for the field of interaction design.......There are many examples of cards used to assist or provide structure to the design process, yet there has not been a thorough articulation of the strengths and weaknesses of the various examples. We review eighteen card-based design tools in order to understand how they might benefit designers...

  7. The fourth Dimension

    CERN Document Server

    Schweitzer, Eugen

    2009-01-01

    In different passages of his dialogues, Plato showed deep mathematically-based physical insights. Regrettably most readers overlooked the respective statements, or they utterly did not understand those hints since they were full of philological fallacious terms. Respectable translators misinterpreted such statements and therefore Plato's respective remarks were not recognized as substantial knowledge. Furthermore, Plato often supplemented such basic remarks by diffusely veiled and varied allusions that were often ironically hidden somewhere in his dialogues by inconspicuous double meanings. However, this mode of intentionally coded discrete communication was generally not understood because such irony is not to everyone's taste. However, the attempts to reconstruct Plato's system on the basis of admittedly individually interpreted double meanings lead to a conclusive mathematical-physical cyclical system of dimensions. Additionally it was possible to assign Plato's system of philosophical ideas analogously to...

  8. Phenomenology of Extra Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Hewett, J.L.; /SLAC

    2006-11-07

    If the structure of spacetime is different than that readily observed, gravitational physics, particle physics and cosmology are all immediately affected. The physics of extra dimensions offers new insights and solutions to fundamental questions arising in these fields. Novel ideas and frameworks are continuously born and evolved. They make use of string theoretical features and tools and they may reveal if and how the 11-dimensional string theory is relevant to our four-dimensional world. We have outlined some of the experimental observations in particle and gravitational physics as well as astrophysical and cosmological considerations that can constrain or confirm these scenarios. These developing ideas and the wide interdisciplinary experimental program that is charted out to investigate them mark a renewed effort to describe the dynamics behind spacetime. We look forward to the discovery of a higher dimensional spacetime.

  9. Qubits from extra dimensions

    CERN Document Server

    Lévay, Péter

    2011-01-01

    We link the recently discovered black hole-qubit correspondence to the structure of extra dimensions. In particular we show that for toroidal compactifications of type IIB string theory simple qubit systems arise naturally from the geometrical data of the tori parametrized by the moduli. We also generalize the recently suggested idea of the attractor mechanism as a distillation procedure of GHZ-like entangled states on the event horizon, to moduli stabilization for flux attractors in F-theory compactifications on elliptically fibered Calabi-Yau four-folds. Finally using a simple example we show that the natural arena for qubits to show up is an embedded one within the realm of fermionic entanglement of quantum systems with indistinguishable constituents.

  10. Flowing to four dimensions

    CERN Document Server

    Dudas, E; Rubakov, V A

    2006-01-01

    We analyze the properties of a model with four-dimensional brane-localized Higgs type potential of a six dimensional scalar field satisfying the Dirichlet boundary condition on the boundary of a transverse two-dimensional compact space. The regularization of the localized couplings generates classical renormalization group running. A tachyonic mass parameter grows in the infrared, in analogy with the QCD gauge coupling in four dimensions. We find a phase transition at a critical value of the bare mass parameter such that the running mass parameter becomes large in the infrared precisely at the compactification scale. Below the critical coupling, the theory is in symmetric phase, whereas above it spontaneous symmetry breaking occurs. Close to the phase transition point there is a very light mode in the spectrum. The massive Kaluza-Klein spectrum at the critical coupling becomes independent of the UV cutoff.

  11. Serological survey of Toxoplasma gondii, Dirofilaria immitis, Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) infections in pet cats in Bangkok and vicinities, Thailand

    Science.gov (United States)

    The seroprevalence of Toxoplasma gondii, Dirofilaria immitis (heartworm), feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) infections was examined using serum or plasma samples from 746 pet cats collected between May and July 2009 from clinics and hospitals located in and around ...

  12. A two-component signal-transduction cascade in Carnobacterium piscicola LV17B : two signaling peptides and one sensor-transmitter

    NARCIS (Netherlands)

    Kleerebezem, M; Kuipers, OP; de Vos, WM; Stiles, ME; Quadri, LEN; Vos, Willem M. de; Stiles, Michael E.; Quadri, Luis E.N.

    2001-01-01

    In the lactic acid bacterium Carnobacterium piscicola LV17B a peptide-pheromone dependent quorum-sensing mode is involved in the regulation of bacteriocin production. Bacteriocin CB2 was identified as an environmental signal that induces bacteriocin production. Here, we demonstrate that a second 24

  13. Effects of Benzalkonium Chloride, Proxel LV, P3 Hypochloran, Triton X-100 and DOWFAX 63N10 on anaerobic digestion processes

    DEFF Research Database (Denmark)

    Flores, German Antonio Enriquez; Fotidis, Ioannis; Karakashev, Dimitar Borisov

    2015-01-01

    In this study, the individual and synergistic toxicity of the following xenobiotics: Benzalkonium Chloride (BKC), Proxel LV (PRX), P3 Hypochloran (HPC), Triton X-100 (TRX), and DOWFAX 63N10 (DWF), on anaerobic digestion (AD) process, was assessed. The experiments were performed in batch and conti...

  14. A two-component signal-transduction cascade in Carnobacterium piscicola LV17B : two signaling peptides and one sensor-transmitter

    NARCIS (Netherlands)

    Kleerebezem, M; Kuipers, OP; de Vos, WM; Stiles, ME; Quadri, LEN; Vos, Willem M. de; Stiles, Michael E.; Quadri, Luis E.N.

    2001-01-01

    In the lactic acid bacterium Carnobacterium piscicola LV17B a peptide-pheromone dependent quorum-sensing mode is involved in the regulation of bacteriocin production. Bacteriocin CB2 was identified as an environmental signal that induces bacteriocin production. Here, we demonstrate that a second 24

  15. Transspecies Transmission of Gammaretroviruses and the Origin of the Gibbon Ape Leukaemia Virus (GaLV and the Koala Retrovirus (KoRV

    Directory of Open Access Journals (Sweden)

    Joachim Denner

    2016-12-01

    Full Text Available Transspecies transmission of retroviruses is a frequent event, and the human immunodeficiency virus-1 (HIV-1 is a well-known example. The gibbon ape leukaemia virus (GaLV and koala retrovirus (KoRV, two gammaretroviruses, are also the result of a transspecies transmission, however from a still unknown host. Related retroviruses have been found in Southeast Asian mice although the sequence similarity was limited. Viruses with a higher sequence homology were isolated from Melomys burtoni, the Australian and Indonesian grassland melomys. However, only the habitats of the koalas and the grassland melomys in Australia are overlapping, indicating that the melomys virus may not be the precursor of the GaLV. Viruses closely related to GaLV/KoRV were also detected in bats. Therefore, given the fact that the habitats of the gibbons in Thailand and the koalas in Australia are far away, and that bats are able to fly over long distances, the hypothesis that retroviruses of bats are the origin of GaLV and KoRV deserves consideration. Analysis of previous transspecies transmissions of retroviruses may help to evaluate the potential of transmission of related retroviruses in the future, e.g., that of porcine endogenous retroviruses (PERVs during xenotransplantation using pig cells, tissues or organs.

  16. Interactive Dimensioning of Parametric Models

    KAUST Repository

    Kelly, T.

    2015-05-01

    We propose a solution for the dimensioning of parametric and procedural models. Dimensioning has long been a staple of technical drawings, and we present the first solution for interactive dimensioning: A dimension line positioning system that adapts to the view direction, given behavioral properties. After proposing a set of design principles for interactive dimensioning, we describe our solution consisting of the following major components. First, we describe how an author can specify the desired interactive behavior of a dimension line. Second, we propose a novel algorithm to place dimension lines at interactive speeds. Third, we introduce multiple extensions, including chained dimension lines, controls for different parameter types (e.g. discrete choices, angles), and the use of dimension lines for interactive editing. Our results show the use of dimension lines in an interactive parametric modeling environment for architectural, botanical, and mechanical models. © 2015 The Author(s) Computer Graphics Forum © 2015 The Eurographics Association and John Wiley & Sons Ltd. Published by John Wiley & Sons Ltd.

  17. Mechanical Behaviors and Elastic Parameters of Laminated Fabric URETEK3216LV Subjected to Uniaxial and Biaxial Loading

    Science.gov (United States)

    Chen, Jianwen; Chen, Wujun; Wang, Mingyang; Ding, Yong; Zhou, Han; Zhao, Bing; Fan, Jin

    2017-01-01

    A comprehensive experimental study of the laminated fabric URETEK3216LV subjected to mono-uniaxial, uniaxial cyclic and biaxial cyclic loading was performed to expose the detailed mechanical behaviors and determine proper elastic parameters for the laminated fabrics under specific stress states. The elastic modulus-strain curves and elastic parameter response surfaces were used to reveal the mechanical behaviors, and a weighted average method of integrals was proposed to calculate the elastic parameters for different stress states. Results show that typical stress-strain curves consist of three distinct regions during loading: crimp region, nonlinear transition region and yarn extension region, which is consistent with those of the constitutive yarns. The elastic parameters and mechanical behaviors of the laminated fabric are stress-state specific, and they vary noticeably with the experimental protocols, stress ratios and stress levels. The proposed method is feasible to evaluate the elastic parameters no matter what stress states the materials are subjected to, and thus it may offer potential access to obtain accurate design and analysis of the airship structures under different loading conditions.

  18. Protective effects of Ping-Lv-Mixture (PLM), a medicinal formula on arrhythmias induced by myocardial ischemia-reperfusion.

    Science.gov (United States)

    An, Wei; Yang, Jing

    2006-11-03

    Ping-Lv-Mixture (PLM) is a Chinese medicinal formula. The present study aimed to determine the effects of PLM on myocardial ischemia-reperfusion (MI/R) induced arrhythmias in rats. Arrhythmia model was established by occlusion of the left arterial descending coronary artery and thereafter reperfusion. A lead II electrocardiogram was monitored throughout the experiment. The results showed that pretreatment of PLM to MI/R rats significantly reduced the incidence and duration of ventricular tachycardia and ventricular fibrillation. On induction of MI/R, the activities of creatine kinase and lactate dehydrogenase were increased in vehicle group. PLM (0.04-1.00 g/kg) administration prevented the increase of these enzymes. Moreover, a significant increase of myocardium superoxide dismutase and decrease of malondialdehyde contents were observed in rats of PLM groups. On the other hand, the expressions of platelet activating factor (PAF) receptor mRNA was down-regulated in a dose-dependent manner in the PLM-treated groups by RT-PCR. Thus, it can be concluded that pretreatment with PLM inhibited lipid peroxidation in rats through suppressing the expression of PAF receptor, which may contribute to its preventive effect on myocardial ischemia-reperfusion induced arrhythmias.

  19. Analysis of Maneuvering Targets with Complex Motions by Two-Dimensional Product Modified Lv's Distribution for Quadratic Frequency Modulation Signals.

    Science.gov (United States)

    Jing, Fulong; Jiao, Shuhong; Hou, Changbo; Si, Weijian; Wang, Yu

    2017-06-21

    For targets with complex motion, such as ships fluctuating with oceanic waves and high maneuvering airplanes, azimuth echo signals can be modeled as multicomponent quadratic frequency modulation (QFM) signals after migration compensation and phase adjustment. For the QFM signal model, the chirp rate (CR) and the quadratic chirp rate (QCR) are two important physical quantities, which need to be estimated. For multicomponent QFM signals, the cross terms create a challenge for detection, which needs to be addressed. In this paper, by employing a novel multi-scale parametric symmetric self-correlation function (PSSF) and modified scaled Fourier transform (mSFT), an effective parameter estimation algorithm is proposed-referred to as the Two-Dimensional product modified Lv's distribution (2D-PMLVD)-for QFM signals. The 2D-PMLVD is simple and can be easily implemented by using fast Fourier transform (FFT) and complex multiplication. These measures are analyzed in the paper, including the principle, the cross term, anti-noise performance, and computational complexity. Compared to the other three representative methods, the 2D-PMLVD can achieve better anti-noise performance. The 2D-PMLVD, which is free of searching and has no identifiability problems, is more suitable for multicomponent situations. Through several simulations and analyses, the effectiveness of the proposed estimation algorithm is verified.

  20. Binding of Dumbbell Oligonucleotides to MoMuLV Reverse Transcriptase: Inhibitory Properties of RNase H Activity

    Directory of Open Access Journals (Sweden)

    Ajay Kumar

    2010-01-01

    Full Text Available Dumbbell oligonucleotides with loops of various chemistry were synthesized. Incubation of dumbbell oligonucleotides containing phosphorothioate bonds or trimethylene phosphate linkages in loops with S1 nuclease did not result in significant cleavage under conditions which led to the degradation of dumbbell oligonucleotide containing phophodiester bonds in the loops. The binding of reverse transcriptase of Moloney Murine Leukemia Virus (MoMuLV was evaluated with all the five oligonucleotides. The protein binds to all the dumbbell oligonucleotides with similar affinity. The dissociation constants evaluated using PAGE band mobility shift assays were of the order of 10-7. The inhibitory properties of the retroviral RNase H activity was evaluated using 3H –UTP-labeled RNA:RNA-DNA hybrid. It was found that the best dumbbell oligonucleotide, inhibitor contained phosphorothioate residues in both the loops. Our value studies demonstrated that this particularly designed oligonucleotide displays an IC50 of 18 nM in its inhibition on the reverse transcriptase RNase H activity, a magnitude lower than that of first nucleotide reverse transcriptase of HIV-1, tenofovir, introduced by Gilead Science in the market.

  1. The Effect of Phenazine-1-Carboxylic Acid on Mycelial Growth of Botrytis cinerea Produced by Pseudomonas aeruginosa LV Strain

    Directory of Open Access Journals (Sweden)

    Ane S. Simionato

    2017-06-01

    Full Text Available One of the most important postharvest plant pathogens that affect strawberries, grapes and tomatoes is Botrytis cinerea, known as gray mold. The fungus remains in latent form until spore germination conditions are good, making infection control difficult, causing great losses in the whole production chain. This study aimed to purify and identify phenazine-1-carboxylic acid (PCA produced by the Pseudomonas aeruginosa LV strain and to determine its antifungal activity against B. cinerea. The compounds produced were extracted with dichloromethane and passed through a chromatographic process. The purity level of PCA was determined by reversed-phase high-performance liquid chromatography semi-preparative. The structure of PCA was confirmed by nuclear magnetic resonance and electrospray ionization mass spectrometry. Antifungal activity was determined by the dry paper disk and minimum inhibitory concentration (MIC methods and identified by scanning electron microscopy and confocal microscopy. The results showed that PCA inhibited mycelial growth, where MIC was 25 μg mL-1. Microscopic analysis revealed a reduction in exopolysaccharide (EPS formation, showing distorted and damaged hyphae of B. cinerea. The results suggested that PCA has a high potential in the control of B. cinerea and inhibition of EPS (important virulence factor. This natural compound is a potential alternative to postharvest control of gray mold disease.

  2. Molecular characterizations of a novel putative DNA-binding protein LvDBP23 in marine shrimp L. vannamei tissues and molting stages.

    Directory of Open Access Journals (Sweden)

    Yanisa Laoong-u-thai

    Full Text Available BACKGROUND: Litopenaeus Vannamei, well known as pacific white shrimp, is the most popular shrimp in the world shrimp market. Identification and characterization of shrimp muscle regulatory genes are not only important for shrimp genetic improvement, but also facilitate comparative genomic tools for understanding of muscle development and regeneration. METHODOLOGY/PRINCIPAL FINDINGS: A novel mRNA encoding for a putative DNA-binding protein LvDBP23 was identified from Litopenaeus vannamei abdominal muscle cDNA library. The LvDBP23 cDNA contains 639 nucleotides of protein-coding sequence with deduced 212 amino acids of predicted molecular mass 23.32 kDa with glycine-rich domain at amino acid position 94-130. The mRNA sequence is successfully used for producing LvDBP23 recombinant protein in sf9 insect cell expression system. The expression of LvDBP23 mRNA is presented in abdominal muscle and swimming leg muscle, as well as other tissues including intestine, lymphoid and gill. The mRNA expression has the highest level in abdominal muscle in all tested tissues. LVDBP23 transcript during the molt cycle is highly expressed in the intermolt stage. In vitro nucleic acid-binding assays reveal that LvDBP23 protein can bind to both ssDNA and dsDNA, indicating its possible role of regulation of gene transcription. CONCLUSIONS/SIGNIFICANCE: We are the first to report a DNA-binding protein identified from the abdominal muscle tissue of marine shrimp L. Vannamei. Its high-level specific expression during the intermot stage suggests its role in the regulation of muscle buildup during the growth phase of shrimp molt cycle.

  3. Formulation development, optimization and study on drug release kinetics of Eudragit® L100-HPMC E15 LV mixed film-coated colon-targeted Mesalamine tablets

    Directory of Open Access Journals (Sweden)

    A Maria John Newton

    2012-01-01

    Full Text Available The study was designed to evaluate the in vitro dissolution characteristics of pH-sensitive polymer - HPMC E 15 LV-coated tablets - in various simulated fluids (pH range 1.2, 6, 7.2. The Mesalamine tablets were fabricated by mixing the drug with microcrystalline cellulose and other ingredients. The fabricated Mesalamine tablets were coated with Eudragit L100 polymer and HPMC E 15 LV. The fluctuation in colonic pH conditions during inflammatory bowel disease and the nature of less fluid content in the colon may limit the expected drug release in the colon. Addition of HPMC E 15 LV may control this problem by hydrophilic nature and excellent film-forming characteristics like ductility and elasticity. The different batches of Mesalamine tablets (FM1-FM5 were coated with increasing concentration of Eudragit L100 and HPMC E 15 LV. The coating was given up to 8% TWG(Total weight gain of the uncoated tablet. Drug release studies were conducted in different pH conditions in the presence of rat ceaecal contents. The different buffer conditions were chosen to mimic the pH changes in the terminal part of the ileum as well as in the colon. The drug release profile was analyzed for colon-targeting performance in vitro. The release profile of the tablets indicates that the drug release was retarded in the tablet by film coating. The addition of HPMC E 15 LV ensures the channels for allowing colonic fluids to penetrate into the core and subsequent drug release at the target site. The kinetics of the drug release also evaluated the release pattern that was best fitted with Higuchian release. The results of the mechanism of release revealed that drug release was found to be a complex one with diffusion, erosion and swelling.

  4. Thermal dimension of quantum spacetime

    CERN Document Server

    Amelino-Camelia, Giovanni; Gubitosi, Giulia; Santos, Grasiele

    2016-01-01

    Recent results suggest that a crucial crossroad for quantum gravity is the characterization of the effective dimension of spacetime at short distances, where quantum properties of spacetime become significant. This is relevant in particular for various scenarios of "dynamical dimensional reduction" which have been discussed in the literature. We are here concerned with the fact that the related research effort has been based exclusively on analyses of the "spectral dimension", which involves an unphysical Euclideanization of spacetime and is highly sensitive to the off-shell properties of a theory. As here shown, different formulations of the same physical theory can have wildly different spectral dimension. We propose that dynamical dimensional reduction should be described in terms of the "thermal dimension" which we here introduce, a notion that only depends on the physical content of the theory. We analyze a few models with dynamical reduction both of the spectral dimension and of our thermal dimension, f...

  5. Anomalous Dimensions of Conformal Baryons

    DEFF Research Database (Denmark)

    Pica, Claudio; Sannino, Francesco

    2016-01-01

    We determine the anomalous dimensions of baryon operators for the three color theory as function of the number of massless flavours within the conformal window to the maximum known order in perturbation theory. We show that the anomalous dimension of the baryon is controllably small, within...... the $\\delta$-expansion, for a wide range of number of flavours. We also find that this is always smaller than the anomalous dimension of the fermion mass operator. These findings challenge the partial compositeness paradigm....

  6. Beta Function and Anomalous Dimensions

    CERN Document Server

    Pica, Claudio

    2010-01-01

    We demonstrate that it is possible to determine the coefficients of an all-order beta function linear in the anomalous dimensions using as data the two-loop coefficients together with the first one of the anomalous dimensions which are universal. The beta function allows to determine the anomalous dimension of the fermion masses at the infrared fixed point, and the resulting values compare well with the lattice determinations.

  7. Anomalous Dimensions of Conformal Baryons

    CERN Document Server

    Pica, Claudio

    2016-01-01

    We determine the anomalous dimensions of baryon operators for the three color theory as function of the number of massless flavours within the conformal window to the maximum known order in perturbation theory. We show that the anomalous dimension of the baryon is controllably small for a wide range of number of flavours. We also find that this is always smaller than the anomalous dimension of the fermion mass operator. These findings challenge the partial compositeness paradigm.

  8. Flying in Two Dimensions

    CERN Document Server

    Prakash, Manu

    2011-01-01

    Diversity and specialization of behavior in insects is unmatched. Insects hop, walk, run, jump, row, swim, glide and fly to propel themselves in a variety of environments. We have uncovered an unusual mode of propulsion of aerodynamic flight in two dimensions in Waterlilly Beetles \\emph{(Galerucella)}. The adult beetles, often found in water lilly ponds, propel themselves strictly in a two-dimensional plane on the surface of water via flapping wing flight. Here we analyze the aerodynamics of this peculiar flight mode with respect to forces exerted on the organism during flight. The complexity of 2-D flight is captured by accounting for additional forces beyond gravitational, thrust, lift and drag, exerted on the insect body in 3D flight. Understanding this constrained propulsion mode requires accounting for viscous drag, surface tension, buoyancy force, and capillary-wave drag. Moreover, dramatic differences exist in the magnitude of the resultant forces in 2D vs. 3D flight. Here, in this fluid dynamics video...

  9. Physics in one dimension

    Science.gov (United States)

    van Houselt, A.; Schäfer, J.; Zandvliet, H. J. W.; Claessen, R.

    2013-01-01

    With modern microelectronics moving towards smaller and smaller length scales on the (sub-) nm scale, quantum effects (apart from band structure and band gaps) have begun to play an increasingly important role. This especially concerns dimensional confinement to 2D (high electron mobility transistors and integer/fractional quantum Hall effect physics, graphene and topological insulators) and 1D (with electrical connections eventually reaching the quantum limit). Recent developments in the above-mentioned areas have revealed that the properties of electron systems become increasingly exotic as one progresses from the 3D case into lower dimensions. As compared to 2D electron systems, much less experimental progress has been achieved in the field of 1D electron systems. The main reason for the lack of experimental results in this field is related to the difficulty of realizing 1D electron systems. Atom chains created in quantum mechanical break junction set-ups are too short to exhibit the typically 1D signatures. As an alternative, atomic chains can be produced on crystal surfaces, either via assembling them one-by-one using a scanning tunnelling microscope or via self-assembly. The drawback of the latter systems is that the atomic chains are not truly 1D since they are coupled to the underlying crystal and sometimes even to the neighbouring chains. In retrospect, this coupling turns out to be an absolute necessity in the experiment since true 1D systems are disordered at any non-zero temperature [1]. The coupling to the crystal and/or neighbouring chains shifts the phase transition, for example, a Peierls instability, to a non-zero temperature and thus allows experiments to be performed in the ordered state. Here, we want to emphasize that the electronic properties of the 1D electron system are fundamentally different from its 2D and 3D counterparts. The Fermi liquid theory, which is applicable to 2D and 3D electron systems, breaks down spectacularly in the 1D case

  10. DIMENSION STONE DEPOSITS IN CROATIA

    Directory of Open Access Journals (Sweden)

    Branko Crnković

    1993-12-01

    Full Text Available The geology, petrographycal composition and properties of dimension stone deposits in Croatia are described. Dimension stone deposits in the conception of mobilistic view of the genesis and structure of Dinarides, as well as after stratigraphic units, are considered. Valuation of the dimension stones of the active quarries is exposed. The marketable categories of dimension stone in Croatia are different varietes of limestones and calcareous clastites, primarly of Cretaceous age, and to lesser degree of Jurassic and Paleogene. The greatest part of deposits is concentrated in the Adriatic carbonate platform or Adriaticum.

  11. Exterior dimension of fat fractals

    Science.gov (United States)

    Grebogi, C.; Mcdonald, S. W.; Ott, E.; Yorke, J. A.

    1985-01-01

    Geometric scaling properties of fat fractal sets (fractals with finite volume) are discussed and characterized via the introduction of a new dimension-like quantity which is called the exterior dimension. In addition, it is shown that the exterior dimension is related to the 'uncertainty exponent' previously used in studies of fractal basin boundaries, and it is shown how this connection can be exploited to determine the exterior dimension. Three illustrative applications are described, two in nonlinear dynamics and one dealing with blood flow in the body. Possible relevance to porous materials and ballistic driven aggregation is also noted.

  12. Warped Geometry in Higher Dimensions with an Orbifold Extra Dimension

    CERN Document Server

    Ito, M

    2001-01-01

    We solve the Einstein equations in higher dimensions with warped geometry where an extra dimension is assumed to have orbifold symmetry, $S^{1}/Z_{2}$. The setup we consider here is an extension to (5+D)-dimensions of the 5-dimensional Randall-Sundrum model, and two hidden brane and observable brane are fixed on orbifold. Anisotropic cosmological constant on each brane with (4+D)-dimensional spacetime is assumed, and the warped metric of 4-dimensions is generally different from one of extra D-dimensions. It is pointed out that the form of metric depends on both the sign of bulk cosmological constant and initial condition of brane world. Furthermore, anisotropic cosmological constant on each brane can be realized due to the presence of brane.

  13. Efectos combinados de la vitamina c y e dietéticas en la inmunorespuest del juvenil lv antes y después de la suplementación con glucanos

    OpenAIRE

    Molina, César; Rodríguez, Jenny; Arango, José Ignacio; Echeverría, Fabrizio; Sotomayor, Mariuxi

    2002-01-01

    Efectos combinados de la vitamina C y E dietéticas en la inmunorespuest del juvenil LV antes y después de la suplementación con glucanos Efectos combinados de la vitamina C y E dietéticas en la inmunorespuest del juvenil LV antes y después de la suplementación con glucanos

  14. Astakine LvAST binds to the β subunit of F1-ATP synthase and likely plays a role in white shrimp Litopeneaus vannamei defense against white spot syndrome virus.

    Science.gov (United States)

    Liang, Gao-Feng; Liang, Yan; Xue, Qinggang; Lu, Jin-Feng; Cheng, Jun-Jun; Huang, Jie

    2015-03-01

    Cytokines play a critical role in innate and adaptive immunity. Astakines represent a group of invertebrate cytokines that are related to vertebrate prokineticin and function in promoting hematopoiesis in crustaceans. We have identified an astakine from the white shrimp Litopeneaus vannamei and named it LvAST in a previous research. In the present research, we investigated the interactions among LvAST, the envelope protein VP37 of white spot syndrome virus (i.e., WSSV), and the β subunit of F1-ATP synthase (ATPsyn-β) of the white shrimp (i.e., BP53) using binding assays and co-precipitations. We also examined the effects of LvAST on shrimp susceptibility to WSSV. We found that LvAST and VP37 competitively bound to BP53, but did not bind to each other. Shrimps that had been injected with recombinant LvAST exhibited significantly lower mortality and longer survival time in experimental infections by WSSV. In contrast, shrimps whose LvAST gene expression had been inhibited by RNA interference showed significantly higher WSSV infection intensity and shorter survival time following viral challenges. These results suggested that LvAST and WSSV both likely use ATPsyn-β as a receptor and LvAST plays a role in shrimp defense against WSSV infection. This represented the first research showing the involvement of astakines in host antiviral immunity.

  15. A phase II experience with neoadjuvant irinotecan (CPT-11, 5-fluorouracil (5-FU and leucovorin (LV for colorectal liver metastases

    Directory of Open Access Journals (Sweden)

    Bigam David

    2009-05-01

    Full Text Available Abstract Background Chemotherapy may improve survival in patients undergoing resection of colorectal liver metastases (CLM. Neoadjuvant chemotherapy may help identify patients with occult extrahepatic disease (averting unnecessary metastasectomy, and it provides in vivo chemosensitivity data. Methods A phase II trial was initiated in which patients with resectable CLM received CPT-11, 5-FU and LV for 12 weeks. Metastasectomy was performed unless extrahepatic disease appeared. Postoperatively, patients with stable or responsive disease received the same regimen for 12 weeks. Patients with progressive disease received either second-line chemotherapy or best supportive care. The primary endpoint was disease-free survival (DFS; secondary endpoints included overall survival (OS and safety. Results 35 patients were accrued. During preoperative chemotherapy, 16 patients (46% had grade 3/4 toxicities. Resection was not possible in 5 patients. One patient died of arrhythmia following surgery, and 1 patient had transient liver failure. During the postoperative treatment phase, 12 patients (55% had grade 3/4 toxicities. Deep venous thrombosis (DVT occurred in 11 patients (34% at various times during treatment. Of those who underwent resection, median DFS was 23.0 mo. and median OS has not been reached. The overall survival from time of diagnosis of liver metastases was 51.6 mo for the entire cohort. Conclusion A short course of chemotherapy prior to hepatic metastasectomy may serve to select candidates best suited for resection and it may also direct postoperative systemic treatment. Given the significant incidence of DVT, alternative systemic neoadjuvant regimens should be investigated, particularly those that avoid the use of a central venous line. Trial Registration ClinicalTrials.gov NCT00168155.

  16. 2D longitudinal LV speckle tracking strain pattern in breast cancer survivors: sports activity vs exercise as prescription model.

    Science.gov (United States)

    Galanti, Giorgio; Pedrizzetti, Gianni; Pedri, Stefano; Stefani, Laura

    2017-09-05

    Prevention strategies are important to optimize and to manage heart care in breast cancer survivors. Regular physical activity at moderate intensity is normally proposed to maintain myocardial performance; however, no data is available about the different impact of different levels of physical exercise. 2D speckle tracking echocardiography (2DSTE) is an accepted method for early detection of myocardial dysfunction. The study aims to monitor the cardiac performances in breast cancer survivors by 2DSTE analysis to manage sports activity vs physical activity. Two groups of previous breast cancer survivors (33 BCS) trained at moderate intensity and 55 athletes practicing dragon boat (DBA) sport were enrolled. They were matched with two healthy subjects groups: 23 competitive female athletes practicing different sports and 20 healthy women trained with exercise as prescription model. All women were studied by a complete echo examination including LV global longitudinal strain (GLS) assessment (XStrain-Esaote). EF and GS are only significantly higher in healthy subjects (-25.4 ± 2.1). Nevertheless, GLS values are within the normal range for all groups. Particularly, GS does not show any significant differences among subjects (-19.93 ± 4) practicing exercise as prescription when compared to the DBA competitive trained group. 2DSTE method is an appropriate method to supervise the intensity of exercise in breast cancer patients. Particularly, GLS can optimize and improve cancer therapy supporting and creating efficiencies within the health system confirming the role of the exercise prescription therapy in maintaining normal heart function.

  17. Timing in resolution of left heart dilation according to the degree of mitral regurgitation in children with ventricular septal defect after surgical closure

    Directory of Open Access Journals (Sweden)

    Hwa Jin Cho

    2014-01-01

    Full Text Available OBJECTIVE: Children with ventricular septal defects (VSD can have chronic volume overload, which can result in changes of left heart echocardiographic parameters. To evaluate the changes before and after surgical closure, the children were divided into three groups according to the degree of mitral regurgitation (MR, and their echocardiographic characteristics were reviewed at serial follow-up after surgical closure. METHODS: The preoperative, and one-, three-, and 12-month postoperative echocardiographic data of 40 children who underwent surgical closure of VSD were retrospectively reviewed. Left ventricular end-diastolic volume (LVEDV, left ventricular end-diastolic dimension (LVEDD, left ventricular end-systolic dimension (LVESD, mitral valvular characteristics, including degree of MR and mitral valve annulus, and left atrial (LA characteristics, including volume and dimensions, were observed. RESULTS: Preoperative LVEDV, LVEDD, LVESD, mitral valvular annulus, LA volume, and LA dimensions were significantly larger in children with MR. Additionally, there were significant decreases in LVEDV, LVEDD, LA volume, and LA dimensions at one, three, and 12 months postoperatively. The degree of MR also improved to a lower grade after surgical closure of the VSD without additional mitral valve repair. CONCLUSION: The echocardiographic parameters of left heart dilation and MR in children with VSD improved within the first year after surgical closure without additional mitral valve repair. Furthermore, in all of the patients with VSD, regardless of MR, LA dilation was reduced within three months after surgical closure of the VSD; however, LV and mitral valve annular dilatation decreased within 12 months.

  18. Saliency of social comparison dimensions

    NARCIS (Netherlands)

    Kuyper, H.

    2007-01-01

    The present article discusses a theory of the saliency of social comparison dimensions and presents the results of an experiment about the effects of two different experimental situations on the saliency of exterior, task-related and socio-emotional dimensions. Saliency was operationalized with a

  19. Dimensioning, Tolerancing, and Machine Finishes.

    Science.gov (United States)

    Adams, George C.

    Intended for use with the vocational education student interested in technical drawing, this guide provides answers to questions relating to dimensioning and tolerancing machine drawings. It also gives examples of standard dimensioning practices, tolerancing applications, and finish applications. The problems and examples presented are based on…

  20. Anomalous Dimensions of Conformal Baryons

    DEFF Research Database (Denmark)

    Pica, Claudio; Sannino, Francesco

    2016-01-01

    We determine the anomalous dimensions of baryon operators for the three color theory as function of the number of massless flavours within the conformal window to the maximum known order in perturbation theory. We show that the anomalous dimension of the baryon is controllably small, within...

  1. Mathematics Teachers' Criteria of Dimension

    Science.gov (United States)

    Ural, Alattin

    2014-01-01

    The aim of the study is to determine mathematics teachers' decisions about dimensions of the geometric figures, criteria of dimension and consistency of decision-criteria. The research is a qualitative research and the model applied in the study is descriptive method on the basis of general scanning model. 15 mathematics teachers attended the…

  2. The Hausdorff Dimension of Sections

    Institute of Scientific and Technical Information of China (English)

    Min NIU; Lifeng XI

    2007-01-01

    The notion of finite-type open set condition is defined to calculate the Hausdorff dimensions of the sections of some self-similar sets, such as the dimension of intersection of the Koch curve and the line x = a with a ∈(Q).

  3. Anomalous Dimensions of Conformal Baryons

    DEFF Research Database (Denmark)

    Pica, Claudio; Sannino, Francesco

    2016-01-01

    We determine the anomalous dimensions of baryon operators for the three color theory as function of the number of massless flavours within the conformal window to the maximum known order in perturbation theory. We show that the anomalous dimension of the baryon is controllably small, within the $...

  4. Beta Function and Anomalous Dimensions

    DEFF Research Database (Denmark)

    Pica, Claudio; Sannino, Francesco

    2011-01-01

    We demonstrate that it is possible to determine the coefficients of an all-order beta function linear in the anomalous dimensions using as data the two-loop coefficients together with the first one of the anomalous dimensions which are universal. The beta function allows to determine the anomalou...

  5. Left ventricular regional and global diastolic function assessed using Quantitative Tissue velocity Imaging in patients with hypertrophic cardiomyopathy

    Institute of Scientific and Technical Information of China (English)

    王良玉; 王新房; 谢明星; 蔡志雄; 陈纪平

    2003-01-01

    Objectives The study was performed to assess the left ventricular (LV) regional and global diastolic function、 left ventricular wall motion features in patients with Hypertrophic cardiomyopathy by Quantitative Tissue Velocity Imaging (QTVI).Methods 42 patients with hypertrophic cardiomyopathy and 36 age-matched normal subjects underwent QTVI study. Off-line LV regional muscular tissue velocity Imaging along LV aplcal long-axis view were obtained. Regional diastolic function was assessed in using peak tissue velocities of LV regional muscular tissue during early diastole (Ve)and LA contraction (Va) , Ve/Va ratio, derived from Tissue Velocity Imaging. Global diastolic function was reflected by isovolumic relaxation time(IRT) and mitral valve peak flow velocity ( E/A ) calculated with pulsed wave doppler.The end-diastolic interventricular septal thickness (IVSt) was measured by conventional 2 - dimension the segments of hypertrophic interventricular septum (IVS) reduced wlhile E/A ratio significantly reduced and IRT markedly prolonged in HCM patients than in duced in the segments of hypertrophic interventricular septum compared with other LV segments in HCM paE/A in HCM patients with abnormal E/A ratio (r = 0.Va and IVSt in non- obstruction HCM patients (B group , r = - 0.61 ) Conclusions QTVI offers a newer method in clinical practice which has a higher sensibility and accuracy in evaluating the LV regional and global diastolic function in HCM patients.

  6. The influence of right ventricular apical pacing on left atrial volume in patients with normal left ventricular function

    Directory of Open Access Journals (Sweden)

    AR Moaref1

    2008-03-01

    Full Text Available Background: Right ventricular apical (RVA pacing has been reported to induce several deleterious effects particularly in the presence of structural heart disease but can also involve patients with normal left ventricular (LV function. Left atrial (LA enlargement is one of these effects, but the majority of studies have measured LA dimension rather than volume.Objective: The present prospective study was designed to assess the effect of RVA pacing on LA volume in patients with normal LV function.Patients and Methods: The study comprised 41 consecutive patients with LV ejection fraction ≥ 45% and LV end diastolic dimension ≤ 56 mm who underwent single-or dual- chamber pacemaker implantation in RVA and followed for LA volume measurement and pacemaker analysis at least during the ensuing 4.2 months. Results: In all, 21 patients were excluded from the study due to five spontaneous wide QRS complex (≥120msec, one recent acute coronary syndrome,one significant valvular heart disease, three pacing frequency <90%, eight death or losing follow up in three cases. In remaining 20 patients, LA volume ragned from 21 to 54 mm3 with mean of 37.3±9.7 mm3 prior to pacemaker implantation that increased to 31 to 103 mm3 (54.3±17.0 during follow-up (P<0.001.Conclusion: RVA pacing might lead to an increase in LA volume even in patients with normal LV function.

  7. 浅谈吕叔湘的作文教学观%A Brief Discussion on Lv Shuxiang's Teaching Idea of Writing

    Institute of Scientific and Technical Information of China (English)

    郑礼立

    2012-01-01

    Writing teaching is a most important link in Chinese teaching,so many Chinese educators have deeply studied on writing teaching,including Lv Shuxiang.This paper summarizes and introduces Mr.Lv's teaching idea of writing from four aspects:title of a composition,teaching methods of writing,requirements of writing and writing assessment.%作文教学是语文教学中最重要的环节之一,许多语文学家都对此进行了深入的研究,吕叔湘先生也不例外。这篇文章主要从作文题目、作文教学方法、作文要求、作文评改等四个方面对吕老的作文观点进行了整合与介绍。

  8. Landslide risk assessment in the Göta Älv river valley to limit consequences of climate change on society

    Science.gov (United States)

    Hedlund, Jonas; Lind, Bo; Tremblay, Marius; Zackrisson, Peter; Cederbom, Charlotte

    2010-05-01

    Higher temperatures, higher average precipitation and increased occurrence of extreme rainfall events are some expected climate changes in Sweden during the coming 70-100 years. Due to the changing climate the risk for floods, erosion and landslides are expected to increase. in large parts of the country. To prevent extensive floodings and damages of cities and infrastructure around Lake Vänern, it is necessary to allow controlled overflow from Lake Vänern through the river Göta Älv. An overflow in the river, in turn, leads to increased risk for erosion and landslides along the Göta Älv valley. In order to meet the upcoming climate changes and to handle the increasing flows through the river, we need to improve the knowledge of the stability of the entire river bank. The Swedish Government has commissioned the Swedish Geotechnical Institute (SGI) to investigate the landslide potential of the Göta Älv valley, taking the predicted climate changes into consideration. The investigated area includes the parts of Göta Älv that could be affected by the increased flows from Lake Vänern; areas where the increased flow will affect stability and where landslides could cause serious damages or damming of the river. The investigation area includes c. 90 km of the Göta Älv river plus tributaries in connection to Göta Älv. In the landslide risk analyses developed for Göta Älv, the likelihood of landslides and estimation of the subsequent consequences are included. The methodology involves mapping of landslide hazards and a judgement of the risk area on the basis of a risk matrix. The landslide risk analysis allows for an assessment of where geotechnical reinforcements would be necessary. A cost estimation for the required reinforcement measures is also provided. In areas where the estimated risk for a landslide is low (e.g. limited consequences), stability mapping in accordance with the model used by the Swedish Civil Contingencies Agency (MSB) is developed

  9. Evaluation of left ventricular enlargement as a marker of early disease in familial dilated cardiomyopathy.

    Science.gov (United States)

    Fatkin, Diane; Yeoh, Thomas; Hayward, Christopher S; Benson, Victoria; Sheu, Angela; Richmond, Zara; Feneley, Michael P; Keogh, Anne M; Macdonald, Peter S

    2011-08-01

    Echocardiographic screening of families with dilated cardiomyopathy has identified a subgroup of asymptomatic relatives with left ventricular enlargement (LVE). The prognostic significance of LVE in this setting is incompletely understood. We evaluated 457 asymptomatic relatives in 128 dilated cardiomyopathy families and identified 110 individuals (24%) with LVE. Serial echocardiograms in 72 untreated LVE relatives showed that 9 individuals (13%) had development of dilated cardiomyopathy over 10 to 152 months (median, 52). Thirty LVE relatives and 30 age- and sex-matched healthy control subjects were evaluated using 2-dimensional and M-mode echocardiography, tissue Doppler imaging, noninvasive pressure-volume assessment, exercise stress echocardiography, and brain natriuretic peptide levels. LVE relatives showed mild defects of systolic and diastolic LV function, with normal filling pressures and exercise-induced increments in systolic contraction in most cases. LV dimensions and fractional shortening most effectively differentiated LVE relatives from control subjects, with other functional indices lacking additive discriminative value. In a receiver operating characteristics analysis, the area under the curve for LV end-diastolic diameter (% predicted) was 0.96 (P116% or LV end-diastolic diameter (% predicted) 112% to 116%+fractional shortening ≤29% had high sensitivity (100%) and specificity (93%) for LVE relatives and identified 8 of 9 progressors. LVE is a common finding in asymptomatic relatives in dilated cardiomyopathy families and can be a marker of preclinical cardiomyopathy. Assessment of LV size and contractile function is required for differentiating between pathological and physiological causes of LVE and may help to identify those at risk of disease progression.

  10. Molecular Characterizations of a Novel Putative DNA-Binding Protein LvDBP23 in Marine Shrimp L. vannamei Tissues and Molting Stages

    OpenAIRE

    Yanisa Laoong-u-thai; Baoping Zhao; Amornrat Phongdara; Jinzeng Yang

    2011-01-01

    BACKGROUND: Litopenaeus Vannamei, well known as pacific white shrimp, is the most popular shrimp in the world shrimp market. Identification and characterization of shrimp muscle regulatory genes are not only important for shrimp genetic improvement, but also facilitate comparative genomic tools for understanding of muscle development and regeneration. METHODOLOGY/PRINCIPAL FINDINGS: A novel mRNA encoding for a putative DNA-binding protein LvDBP23 was identified from Litopenaeus vannamei abdom...

  11. A prospective randomized study of irinotecan (CPT-11), leucovorin (LV) and 5-fluorouracil (5FU) versus leucovorin and 5-fluorouracil in patients with advanced colorectal carcinoma.

    Science.gov (United States)

    Gennatas, C; Papaxoinis, G; Michalaki, V; Mouratidou, D; Andreadis, C; Tsavaris, N; Pafiti, A

    2006-10-01

    The purpose of this study was to compare the activity and toxicity of an irinotecan (CPT-11), leucovorin (LV) and 5-fluorouracil (5FU) combination with a standard regimen of 5FU and LV, in patients with advanced colorectal carcinoma. One hundred and sixty patients were randomized; 80 patients (group A) received LV 20 mg/m(2) bolus i.v. and 5FU 425 mg/m(2) bolus i.v. on days 1-5, every 28 days; 80 patients (group B) received CPT-11 80 mg/m(2) (30-90 min i.v. infusion), followed by LV 20 mg/m(2) bolus i.v. and 5FU 425 mg/m(2) bolus i.v. on days 1, 8, 15, 22, 29, and 36, every 8 weeks. The overall response rate was 30% and 47.5% in groups A and B respectively. Progression-free survival was significantly higher in the triple-drug combination arm (median 7.5 vs. 4.5 months; p= 0. 0335). However, overall survival did not differ significantly between the two arms (15 months vs. 14 months for the groups B and A respectively; p=0.3531). The main grade 3 adverse events were diarrhea (19%, in group A vs. 35% in group B; p=0.032) and mucositis (2% vs. 14%; p=0.017). The regimen containing irinotecan showed activity in advanced colorectal cancer. The overall safety data confirm this combination as a well-tolerated treatment.

  12. Handelsgødnings indflydelse på afgrøders indhold af arsen, bly, cadmium, krom, kviksølv og nikkel

    DEFF Research Database (Denmark)

    Christensen, Bent Tolstrup; Elsgaard, Lars

    Denne rapport belyser indholdet af arsen (As), bly (Pb), cadmium (Cd), krom (Cr), kviksølv (Hg) og nikkel (Ni) i afgrøder, der er dyrket ved forskellige niveauer af handelsgødning (fra ugødet til to gange normal gødskning). Effekten af handelsgødning er sammenlignet med effekten af husdyrgødning...

  13. Preimage entropy dimension of topological dynamical systems

    OpenAIRE

    Lei LIU; Zhou, Xiaomin; Zhou, Xiaoyao

    2014-01-01

    We propose a new definition of preimage entropy dimension for continuous maps on compact metric spaces, investigate fundamental properties of the preimage entropy dimension, and compare the preimage entropy dimension with the topological entropy dimension. The defined preimage entropy dimension holds various basic properties of topological entropy dimension, for example, the preimage entropy dimension of a subsystem is bounded by that of the original system and topologically conjugated system...

  14. Supersymmetry breaking with extra dimensions

    Indian Academy of Sciences (India)

    Fabio Zwirner

    2004-02-01

    This talk reviews some aspects of supersymmetry breaking in the presence of extra dimensions. The first part is a general introduction, recalling the motivations for supersymmetry and extra dimensions, as well as some unsolved problems of four-dimensional models of supersymmetry breaking. The central part is a more focused introduction to a mechanism for (super)symmetry breaking, proposed first by Scherk and Schwarz, where extra dimensions play a crucial role. The last part is devoted to the description of some recent results and of some open problems.

  15. The Ethical Dimension of Innovation

    DEFF Research Database (Denmark)

    Nogueira, Leticia Antunes; Nogueira, Tadeu Fernando

    2014-01-01

    The view of innovation as a positive concept has been deeply rooted in business and academic cultures ever since Schumpeter coined the concept of creative destruction. Even though there is a large body of literature on innovation studies, limited attention has been given to its ethical dimension....... In this chapter, the ethical implications of innovations are illustrated with a case study of “destructive creation” in the food industry, and upon which an argumentative analysis is conducted. The main message of this chapter is that innovations have inherent ethical dimensions and that quality innovations...... depend on systematic consideration of these dimensions in the innovation process....

  16. Critical dimension for chaotic cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Hosoya, Akio; Jensen, L.G.; Stein-Schabes, J.A.

    1987-03-16

    Using the ADM formalism for general relativity the approach to a space-time singularity of a general inhomogeneous universe, in an arbitrary number of dimensions, is studied. The question of whether chaotic behaviour is a generic feature of Einstein's equations, in an arbitrary number of dimensions, is explored. We find that models that contain ten or more spatial dimensions are non-chaotic and their approach toward the initial singularity is monotonic, whereas for those with dimensionality between four and nine their approach is chaotic. A clear geometrical picture is constructed whereby this result can be understood.

  17. Signatures of Large Extra Dimensions

    CERN Document Server

    Hossenfelder, S; Stöcker, H

    2004-01-01

    String theory suggests modifications of our spacetime such as extra dimensions and the existence of a mininal length scale. In models with addidional dimensions, the Planck scale can be lowered to values accessible by future colliders. Effective theories which extend beyond the standart-model by including extra dimensions and a minimal length allow computation of observables and can be used to make testable predictions. Expected effects that arise within these models are the production of gravitons and black holes. Furthermore, the Planck-length is a lower bound to the possible resolution of spacetime which might be reached soon.

  18. EFFECT OF MITRAL REGURGITATION ON CHRONIC HEART FAILURE COURSE AND STRUCTURE-FUNCTIONAL HEART STATE

    Directory of Open Access Journals (Sweden)

    V. N. Larina

    2009-01-01

    Full Text Available Aim. To evaluate chronic heart failure (CHF course, functional and structural heart changes in patients with functional mitral regurgitation (MR of various degrees.Material and methods. A total of 104 outpatients (60-85 y. o. with CHF of functional class II-IV by NYHA and functional MR of I-II degrees and MR of III-IV degrees were included into the study groups.Results: Patients in both groups were comparable in sex, age, CHF duration, body mass index, systolic and diastolic blood pressure, clinical state by the clinical state scale, quality of life, anxious and depressive status. The majority of patients with MR III had significant left ventricle (LV systolic dysfunction (p=0,029, severe CHF course (p=0,034, received furosemide (p=0.004 and digoxin (p=0,004. They had significant increase in end-diastolic dimension (p<0,001, end-systolic dimension (p<0,001, left atrium (p=0,004, end-diastolic volume (p<0,001, end-systolic volume (p<0,001, pulmonary artery pressure (p<0,001, decrease in LV relative wall thickness (p=0,021 and LV ejection fraction (p<0,001. Patients of this group were hospitalized because of CHF decompensation and ischemic heart disease exacerbation more often (p=0,045.Conclusion. MR can be considered as one of sensitive predictors of LV geometry and function alteration in CHF patients and play an important role in symptoms development.

  19. EFFECT OF MITRAL REGURGITATION ON CHRONIC HEART FAILURE COURSE AND STRUCTURE-FUNCTIONAL HEART STATE

    Directory of Open Access Journals (Sweden)

    V. N. Larina

    2016-01-01

    Full Text Available Aim. To evaluate chronic heart failure (CHF course, functional and structural heart changes in patients with functional mitral regurgitation (MR of various degrees.Material and methods. A total of 104 outpatients (60-85 y. o. with CHF of functional class II-IV by NYHA and functional MR of I-II degrees and MR of III-IV degrees were included into the study groups.Results: Patients in both groups were comparable in sex, age, CHF duration, body mass index, systolic and diastolic blood pressure, clinical state by the clinical state scale, quality of life, anxious and depressive status. The majority of patients with MR III had significant left ventricle (LV systolic dysfunction (p=0,029, severe CHF course (p=0,034, received furosemide (p=0.004 and digoxin (p=0,004. They had significant increase in end-diastolic dimension (p<0,001, end-systolic dimension (p<0,001, left atrium (p=0,004, end-diastolic volume (p<0,001, end-systolic volume (p<0,001, pulmonary artery pressure (p<0,001, decrease in LV relative wall thickness (p=0,021 and LV ejection fraction (p<0,001. Patients of this group were hospitalized because of CHF decompensation and ischemic heart disease exacerbation more often (p=0,045.Conclusion. MR can be considered as one of sensitive predictors of LV geometry and function alteration in CHF patients and play an important role in symptoms development.

  20. Discussion and Analysis on Common Mistakes in LV Circuit Breaker Type Selection%低压断路器选型误区探析

    Institute of Scientific and Technical Information of China (English)

    王殿光

    2016-01-01

    There are various LV circuit breakers with different manufacturers, specifications and models available in the market. Regarding circuit breaker selection and using, there are some common mistakes of users that influence the actual effect. At best, such mistakes result in malfunction and movement resistance; at worst, they lead to life and property loss. From the aspect of product standard, issues like several common mistakes in LV circuit breaker selection: understanding and selection of parameters like Icu, Ics and Icw of LV circuit breaker; relationship between LV circuit breaker’s utilization category and full selective coordination; full and partial selective protections of circuit breakers in series; influence of circuit breaker’s trip value on selective coordination;let-though energy of LV circuit breaker and function of current limiting circuit breaker are illustrated. Suggestions are proposed on the basis of analysis.%市场上低压断路器的制造商众多,规格、型号各异。用户在选择使用断路器上还存在一些误区影响了实际使用效果,轻者误动拒动、重者遭受财产损失危及生命。文章试图从产品标准着眼解释几个主要对低压断路器选择认识的误区:如何理解和选择低压断路器的Ic u、 Ic s、 Ic w等参数,低压断路器的使用类别与全选择性配合的关系,串联断路器间的全选择性和局部选择性保护,断路器脱扣值的误差对选择性配合的影响,低压断路器的允通能量及限流型断路器的作用等,并在分析的基础上给出作者的建议。

  1. First-in-Human Treatment With a Dendritic Cell-targeting Lentiviral Vector-expressing NY-ESO-1, LV305, Induces Deep, Durable Response in Refractory Metastatic Synovial Sarcoma Patient.

    Science.gov (United States)

    Pollack, Seth M; Lu, Hailing; Gnjatic, Sacha; Somaiah, Neeta; O'Malley, Ryan B; Jones, Robin L; Hsu, Frank J; Ter Meulen, Jan

    2017-10-01

    Effective induction of antitumor T cells is a pivotal goal of cancer immunotherapy. To this end, lentiviral vectors (LV) are uniquely poised to directly prime CD8 T-cell responses via transduction of dendritic cells in vivo and have shown promise as active cancer therapeutics in preclinical tumor models. However, until now, significant barriers related to production and regulation have prevented their widespread use in the clinic. We developed LV305, a dendritic cell-targeting, integration-deficient, replication incompetent LV from the ZVex platform, encoding the full-length cancer-testis antigen NY-ESO-1. LV305 is currently being evaluated in phase 1 and 2 trials in metastatic recurrent cancer patients with NY-ESO-1 positive solid tumors as a single agent and in combination with anti-PD-L1. Here we report on the first patient treated with LV305, a young woman with metastatic, recurrent, therapy-refractive NY-ESO-1 synovial sarcoma. The patient developed a robust NY-ESO-1-specific CD4 and CD8 T-cell response after 3 intradermal injections with LV305, and subsequently over 85% disease regression that is continuing for >2.5 years posttherapy. No adverse events >grade 2 occurred. This case demonstrates that LV305 can be safely administered and has the potential to induce a significant clinical benefit and immunologic response in a patient with advanced stage cancer.

  2. Radiation reaction in various dimensions

    CERN Document Server

    Galtsov, D V

    2002-01-01

    We discuss the radiation reaction problem for an electric charge moving in flat space-time of arbitrary dimensions. It is shown that four is the unique dimension where a local differential equation exists accounting for the radiation reaction and admitting a consistent mass-renormalization (the Dirac-Lorentz equation). In odd dimensions the Huygens principle does not hold; as a result, the radiation reaction force depends on the whole past history of a charge (radiative tail). We show that the divergence in the tail integral can be removed by the mass renormalization only in the 2+1 theory. In even dimensions higher than four, divergences can not be removed by a renormalization.

  3. Dimensions of Intercultural Communication Competence

    Institute of Scientific and Technical Information of China (English)

    郭飞燕

    2016-01-01

    Intercultural communication competence can help us adapt better to the host culture and deal with culture shock suc-cessfully. This paper mainly discusses the dimensions of intercultural communication competence.

  4. Radiation reaction in various dimensions

    Science.gov (United States)

    Gal'Tsov, Dmitri V.

    2002-07-01

    We discuss the radiation reaction problem for an electric charge moving in flat space-time of arbitrary dimensions. It is shown that four is the unique dimension where a local differential equation exists accounting for the radiation reaction and admitting a consistent mass renormalization (the Lorentz-Dirac equation). In odd dimensions Huygens's principle does not hold, and, as a result, the radiation reaction force depends on the whole past history of a charge (radiative tail). We show that the divergence in the tail integral can be removed by the mass renormalization only in the 2+1 theory. In even dimensions higher than four, divergences cannot be removed by the mass renormalization.

  5. The social dimension of entrepreneurship

    DEFF Research Database (Denmark)

    Ulhøi, John Parm

    2005-01-01

    This paper proposes an integrative framework to conceptualize important social dimensions of entrepreneurship. The paper reviews and evaluates the current status of research dealing with entrepreneurship, social capital and trust. The proposed framework rests on the recognition that entrepreneurial...

  6. Inflation from periodic extra dimensions

    CERN Document Server

    Higaki, Tetsutaro

    2016-01-01

    We discuss a realization of a small field inflation based on string inspired supergravities. In theories accompanying extra dimensions, compactification of them with small radii is required for realistic situations. Since the extra dimension can have a periodicity, there will appear (quasi-)periodic functions under transformations of moduli of the extra dimensions in low energy scales. Such a periodic property can lead to a UV completion of so-called multi-natural inflation model where inflaton potential consists of a sum of multiple sinusoidal functions with a decay constant smaller than the Planck scale. As an illustration, we construct a SUSY breaking model, and then show that such an inflaton potential can be generated by a sum of world sheet instantons in intersecting brane models on extra dimensions containing $T^2/{\\mathbb Z}_2$ orbifold. We show also predictions of cosmic observables by numerical analyzes.

  7. Keynote speech: Dimensions of Change

    DEFF Research Database (Denmark)

    Jørgensen, Kenneth Mølbjerg

    2004-01-01

    The presentation seeks to construct a framework for understanding knowledge and knowledge work. I argue that knowledge may be understood as a social construction of reality. I argue that people construct their reality by integrating four dimensions of reality: Facts, logic, values and communication...... introduce a basic framework for understanding knowledge. This is done by means of Wittgenstein's concept of language games. Second, I introduce the four dimensions of reality. Third I relate the model to the disciplines organizational learning and knowledge management...

  8. Phenomenology of universal extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Kong, Kyoungchul; Matchev, Konstantin T.; /Florida U.

    2006-10-01

    In this proceeding, the phenomenology of Universal Extra Dimensions (UED), in which all the Standard Model fields propagate, is explored. We focus on models with one universal extra dimension, compactified on an S{sub 1}/Z{sub 2} orbifold. We revisit calculations of Kaluza-Klein (KK) dark matter without an assumption of the KK mass degeneracy including all possible coannihilations. We then contrast the experimental signatures of low energy supersymmetry and UED.

  9. Timbre Dimensions for Musical Control

    Science.gov (United States)

    Giese, Gregory Roy

    This dissertation addresses the folowing question: Given the technologies to develop and implement any kind of sound generating and controlling device, what will the instrument designer, the composer, and the performer need to know in order to more fully utilize the dimensions of timbre in music and musical performance? This question is approached from the standpoint of music theory. Definitions of timbre and a few examples of related physical and perceptual research are reviewed. Included is a discussion of the essential elements of musical control and of intelligent organization of sound in music. This discussion raises more questions than can be answered simply. It is an attempt to unravel the nature of sound clues and sound qualities as they convey sound identities and musical gesture. A theoretical simplification of sound dimensions for musical use is proposed. Sounds which can be sustained indefinitely consist of steady-state acoustical dimensions. These dimensions rely upon the perceptual phenomenon of simultaneous fusion (synance). Sounds which can not be sustained indefinitely consist of transitions. Transitions may cause successive fusion (sonance). The discussion of steady-state and transition dimensions includes a review of a few informal experiments. This work reveals problems that will influence the musical use of timbre dimensions. It also leads to a theory for the organization and control of timbre dimensions in music. Among the timbre dimensions discussed are: spectral envelope, harmonic content, brightness, phase, inharmonicity, aperiodicity, and temporal transitions. Questions are raised regarding the perception of harmonic content. The effect of register on perception of tones consisting of from two to nine partials is explored and discussed. The size of interval between partials determines a unique quality. This is most apparent with tones consisting of only two or three partials (dions or trions).

  10. HeLv – Helpdesk für Lehrer/innen verhaltensauffälliger Schüler/innen - eine netzbasierte Serviceplattform für Lehrer/innen

    Directory of Open Access Journals (Sweden)

    Stefan Germany

    2012-10-01

    Full Text Available The article presents the serviceplatform HeLv-Helpdesk for teachers for pupils with conduct disorder (http://helv.ph-noe.ac.at. HeLv offers easy access to its monitoring and coaching platform as well as a FAQ, contacts for networking with local institutions and a big offer of specialist literature. The focus of the article is on the genese of the service, actual developments and future work which will concentrate on better dissemination and awareness for the support being given by HeLv.

  11. On transfinite extension of asymptotic dimension

    OpenAIRE

    Radul, Taras

    2006-01-01

    We prove that a transfinite extension of asymptotic dimension asind is trivial. We introduce a transfinite extension of asymptotic dimension asdim and give an example of metric proper space which has transfinite infinite dimension.

  12. Extra dimensions in space and time

    CERN Document Server

    Bars, Itzhak

    2010-01-01

    Covers topics such as Einstein and the Fourth Dimension; Waves in a Fifth Dimension; and String Theory and Branes Experimental Tests of Extra Dimensions. This book offers a discussion on Two-Time Physics

  13. On Gorenstein projective, injective and flat dimensions

    DEFF Research Database (Denmark)

    Christensen, Lars Winther; Frankild, Anders Juel; Holm, Henrik Granau

    2006-01-01

    Gorenstein homological dimensions are refinements of the classical homological dimensions, and finiteness singles out modules with amenable properties reflecting those of modules over Gorenstein rings. As opposed to their classical counterparts, these dimensions do not immediately come with pract...

  14. On Gorenstein projective, injective and flat dimensions

    DEFF Research Database (Denmark)

    Christensen, Lars Winther; Frankild, Anders Juel; Holm, Henrik Granau

    2006-01-01

    Gorenstein homological dimensions are refinements of the classical homological dimensions, and finiteness singles out modules with amenable properties reflecting those of modules over Gorenstein rings. As opposed to their classical counterparts, these dimensions do not immediately come with pract...

  15. On the Estimation of Pointwise Dimension

    CERN Document Server

    Hidaka, Shohei

    2013-01-01

    Our goal in this paper is to develop an effective estimator of fractal dimension. We survey existing ideas in dimension estimation, with a focus on the currently popular method of Grassberger and Procaccia for the estimation of correlation dimension. There are two major difficulties in estimation based on this method. The first is the insensitivity of correlation dimension itself to differences in dimensionality over data, which we term {\\em dimension blindness}. The second comes from the reliance of the method on the inference of limiting behavior from finite data. We propose pointwise dimension as an object for estimation in response to the dimension blindness of correlation dimension. Pointwise dimension is a local quantity, and the distribution of pointwise dimensions over the data contains the information to which correlation dimension is blind. We use a "limit-free" description of pointwise dimension to develop a new estimator. We conclude by discussing potential applications of our estimator as well as...

  16. Study of semi-leptonic decay of B meson, in the ways lvD{sup *} and lvD with ALEPH detector at LEP: measurement of the fragmentation function of b quark and search for D{sup **} states; Etude des desintegrations semi-leptoniques du meson B, dans les canaux D*lv et Dlv, aupres du detecteur ALEPH au LEP: mesure de la fonction de fragmentation du quark b et recherche d`etats D**

    Energy Technology Data Exchange (ETDEWEB)

    Bonis, I. de

    1994-06-01

    This work is dedicated to the measurement of the fragmentation function of the quark b, with the ALEPH detector, at LEP. The main aspects of this measure is to be as independent as possible from any model. For this, we reconstruct the semi-leptonic decay modes of the B meson, in the ways lvD deg., lvD{sup *+} and lvD{sup +}. In a first step, we describe the criteria used to select those modes. Then, we determine the fragmentation function by measuring the ratio X{sub B} = 2 E{sub B} / {radical} S, where E{sub B} is the B meson energy and {radical} s/2 the useful energy in the center of mass. The measure of E{sub B} needs a precise reconstruction of the neutrino energy, which is not detected. We present here the method that we used for this reconstruction. Once the acceptance correction is applied, we obtain, for the variable X{sub B}, a distribution with mean value: < X{sub B} > = 0.711 {+-} 0.009 (stat). To be as independent as possible of the model (Peterson function) used n the Monte-Carlo determination of the acceptance, we do an iterative calculation of the acceptance. We obtain < X{sub B}> = 0.712 {+-} 0.009(stat) {+-} 0.017 (syst). Furthermore, this measure depends of the D** contribution, badly known for now. Therefore, we search this contribution, using the events selected before, on the one hand by a direct observation, on the other hand by reconstructing the mass of the B meson. (author). 64 refs.

  17. Dimensions of attractors in pinched skew products

    OpenAIRE

    Gröger, M.; Jäger, T.

    2011-01-01

    We study dimensions of strange non-chaotic attractors and their associated physical measures in so-called pinched skew products, introduced by Grebogi and his coworkers in 1984. Our main results are that the Hausdorff dimension, the pointwise dimension and the information dimension are all equal to one, although the box-counting dimension is known to be two. The assertion concerning the pointwise dimension is deduced from the stronger result that the physical measure is rectifiable. Our findi...

  18. Higuchi dimension of digital images.

    Directory of Open Access Journals (Sweden)

    Helmut Ahammer

    Full Text Available There exist several methods for calculating the fractal dimension of objects represented as 2D digital images. For example, Box counting, Minkowski dilation or Fourier analysis can be employed. However, there appear to be some limitations. It is not possible to calculate only the fractal dimension of an irregular region of interest in an image or to perform the calculations in a particular direction along a line on an arbitrary angle through the image. The calculations must be made for the whole image. In this paper, a new method to overcome these limitations is proposed. 2D images are appropriately prepared in order to apply 1D signal analyses, originally developed to investigate nonlinear time series. The Higuchi dimension of these 1D signals is calculated using Higuchi's algorithm, and it is shown that both regions of interests and directional dependencies can be evaluated independently of the whole picture. A thorough validation of the proposed technique and a comparison of the new method to the Fourier dimension, a common two dimensional method for digital images, are given. The main result is that Higuchi's algorithm allows a direction dependent as well as direction independent analysis. Actual values for the fractal dimensions are reliable and an effective treatment of regions of interests is possible. Moreover, the proposed method is not restricted to Higuchi's algorithm, as any 1D method of analysis, can be applied.

  19. Personality dimensions of opiate addicts.

    Science.gov (United States)

    Vukov, M; Baba-Milkic, N; Lecic, D; Mijalkovic, S; Marinkovic, J

    1995-02-01

    A survey of 80 opiate addicts included in a detoxification program was conducted at the Institute on Addictions in Belgrade. In addition to a dependence diagnosis and mental disorders based on DSM-III-R, we applied a Tridimensional Personality Questionnaire (TPQ) that measures the 3 major personality dimensions: novelty-seeking (NS), harm avoidance (HA) and reward dependence (RD). When compared with a control group (a sample of Yugoslav undergraduate students), the opiate addicts demonstrate significantly high NS dimension as well as significant divergences of HA and RD subscales. The surveyed opiate addicts demonstrate a high percentage of personality disorders specifically in cluster B. The personality dimensions of opiate addicts showed certain temperament traits, such as: impulsiveness, shyness with strangers, fear of uncertainty and dependence. NS, HA and RD determined by temperament specifics may be an etiological factor in forming of a personality disorder, an affective disorder as well as of a drug choice.

  20. The Geographical Dimension of Terrorism

    Science.gov (United States)

    Hawkins, Houston T.

    The events of September 11 ushered us all into a world in which our security and sense of invulnerability were savagely replaced by vulnerability and irrational fear. To the delight of our adversaries who planned these attacks, we often responded in ways that furthered their agenda by weakening the cultural colossus that we call home. Normally terrorism is viewed as intense but localized violence. Seldom is terrorism viewed in its more expansive dimensions. It is burned into our collective memories as a collapsed building, a shattered bus, an incinerated nightclub, or facilities closed by a few anthrax-laced letters. However, terrorism must be studied in dimensions larger than the view from a news camera. This conclusion forms the intellectual basis for The Geographical Dimension of Terrorism.

  1. Reduced-Dimension Multiuser Detection

    CERN Document Server

    Xie, Yao; Goldsmith, Andrea

    2011-01-01

    We explore several reduced-dimension multiuser detection (RD-MUD) structures that significantly decrease the number of required correlation branches at the receiver front-end, while still achieving performance similar to that of the conventional matched-filter (MF) bank. RD-MUD exploits the fact that the number of active users is typically small relative to the total number of users in the system and relies on ideas of analog compressed sensing to reduce the number of correlators. We first develop a general framework for both linear and nonlinear RD-MUD detectors. We then present theoretical performance analysis for two specific detectors: the linear reduced-dimension decorrelating (RDD) detector, which combines subspace projection and thresholding to determine active users and sign detection for data recovery, and the nonlinear reduced-dimension decision-feedback (RDDF) detector, which combines decision-feedback orthogonal matching pursuit for active user detection and sign detection for data recovery. The t...

  2. Correlated Electrons in Reduced Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Bonesteel, Nicholas E [Florida State Univ., Tallahassee, FL (United States)

    2015-01-31

    This report summarizes the work accomplished under the support of US DOE grant # DE-FG02-97ER45639, "Correlated Electrons in Reduced Dimensions." The underlying hypothesis of the research supported by this grant has been that studying the unique behavior of correlated electrons in reduced dimensions can lead to new ways of understanding how matter can order and how it can potentially be used. The systems under study have included i) fractional quantum Hall matter, which is realized when electrons are confined to two-dimensions and placed in a strong magnetic field at low temperature, ii) one-dimensional chains of spins and exotic quasiparticle excitations of topologically ordered matter, and iii) electrons confined in effectively ``zero-dimensional" semiconductor quantum dots.

  3. The Creative Dimension of Visuality

    DEFF Research Database (Denmark)

    Michelsen, Anders Ib

    2013-01-01

    analysis relying on language/linguistics as a model for explaining culture? More specifically, how can the – creative – novelty of visual culture be addressed by a notion of discourse? This essay will argue that the debate on visual culture is lacking with regard to discerning the creative dimension of its...... own appearance. It will indicate an alternative conceptual framework based on Johann P. Arnason’s draft of tripartite culturalization which focuses on a shift from essences to dimensions of culture. This will be further developed by relating Maurice Merleau-Ponty’s idea of ‘chiasm’ of ‘the visible...... and the invisible’ to the notion of collective creativity and ‘the imaginary institution of society’ of Cornelius Castoriadis. In the theoretical relationship between Merleau-Ponty and Castoriadis it is possible to indicate a notion of visuality as a creative dimension....

  4. Collider searches for extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Landsberg, Greg; /Brown U.

    2004-12-01

    Searches for extra spatial dimensions remain among the most popular new directions in our quest for physics beyond the Standard Model. High-energy collider experiments of the current decade should be able to find an ultimate answer to the question of their existence in a variety of models. Until the start of the LHC in a few years, the Tevatron will remain the key player in this quest. In this paper, we review the most recent results from the Tevatron on searches for large, TeV{sup -1}-size, and Randall-Sundrum extra spatial dimensions, which have reached a new level of sensitivity and currently probe the parameter space beyond the existing constraints. While no evidence for the existence of extra dimensions has been found so far, an exciting discovery might be just steps away.

  5. Chemical abundances in the protoplanetary disc LV 2 (Orion): clues to the causes of the abundance anomaly in H II regions

    Science.gov (United States)

    Tsamis, Y. G.; Walsh, J. R.; Vílchez, J. M.; Péquignot, D.

    2011-04-01

    Optical integral field spectroscopy of the archetype protoplanetary disc LV 2 in the Orion nebula is presented, taken with the Very Large Telescope (VLT) FLAMES/Argus fibre array. The detection of recombination lines (RLs) of C II and O II from this class of objects is reported, and the lines are utilized as abundance diagnostics. The study is complemented with the analysis of Hubble Space Telescope (HST) Faint Object Spectrograph ultraviolet and optical spectra of the target contained within the Argus field of view. By subtracting the local nebula background the intrinsic spectrum of the proplyd is obtained and its elemental composition is derived for the first time. The proplyd is found to be overabundant in carbon, oxygen and neon compared to the Orion nebula and the Sun. The simultaneous coverage over LV 2 of the C III]λ1908 and [O III]λ5007 collisionally excited lines (CELs) and C II and O II RLs has enabled us to measure the abundances of C2 + and O2 + for LV 2 with both sets of lines. The two methods yield consistent results for the intrinsic proplyd spectrum, but not for the proplyd spectrum contaminated by the generic nebula spectrum, thus providing one example where the long-standing abundance anomaly plaguing metallicity studies of H II regions has been resolved. These results would indicate that the standard forbidden-line methods used in the derivation of light metal abundances in H II regions in our own and other galaxies underestimate the true gas metallicity.

  6. Physics with large extra dimensions

    Indian Academy of Sciences (India)

    Ignatios Antoniadis

    2004-02-01

    The recent understanding of string theory opens the possibility that the string scale can be as low as a few TeV. The apparent weakness of gravitational interactions can then be accounted by the existence of large internal dimensions, in the sub-millimeter region. Furthermore, our world must be confined to live on a brane transverse to these large dimensions, with which it interacts only gravitationally. In my lecture, I describe briefly this scenario which gives a new theoretical framework for solving the gauge hierarchy problem and the unification of all interactions. I also discuss a minimal embedding of the standard model, gauge coupling unification and proton stability.

  7. The Ethical Dimension of Innovation

    DEFF Research Database (Denmark)

    Nogueira, Leticia Antunes; Nogueira, Tadeu Fernando

    2014-01-01

    The view of innovation as a positive concept has been deeply rooted in business and academic cultures ever since Schumpeter coined the concept of creative destruction. Even though there is a large body of literature on innovation studies, limited attention has been given to its ethical dimension....... In this chapter, the ethical implications of innovations are illustrated with a case study of “destructive creation” in the food industry, and upon which an argumentative analysis is conducted. The main message of this chapter is that innovations have inherent ethical dimensions and that quality innovations...

  8. Chiral gravity in higher dimensions

    CERN Document Server

    Ootsuka, T; Ura, K; Ootsuka, Takayoshi; Tanaka, Erico; Ura, Kousuke

    2003-01-01

    We construct a chiral theory of gravity in 7 and 8 dimensions, which are equivalent to Einstein-Cartan theory using less variables. In these dimensions, we can construct such higher dimensional chiral gravity because of the existence of gravitational instanton. The octonionic-valued variables in the theory represent the deviation from the gravitational instanton, and from their non-associativity, prevents the theory to be SO(n) gauge invariant. Still the chiral gravity holds G_2 (7-D), and Spin(7) (8-D) gauge symmetry.

  9. Quantum physics in one dimension

    CERN Document Server

    Giamarchi, Thierry

    2004-01-01

    This book presents in a pedagogical yet complete way correlated systems in one dimension. Recent progress in nanotechnology and material research have made one dimensional systems a crucial part of today's physics. After an introduction to the basic concepts of correlated systems, the book gives a step by step description of the techniques needed to treat one dimension, and discusses the resulting physics. Then specific experimental realizations of one dimensional systems such asspin chains, quantum wires, nanotubes, organic superconductors etc. are examined. Given its progressive and pedagogi

  10. DC-link Voltage Control to Compensate Voltage Deviation for PV–BESSs Integrated System in Low-Voltage (LV Networks

    Directory of Open Access Journals (Sweden)

    Lee Gyu-sub

    2016-01-01

    Full Text Available The exhaustion of fossil fuel and the greenhouse gas emission are one of the most significant energy and environmental issues, respectively. Photovoltaic (PV generators and battery energy storage systems (BESSs have been significantly increased for recent years. The BESSs are mainly used for smoothing active power fluctuation of the PV. In this paper, PV–BESSs integration of two DC/DC converters and one AC/DC converter is investigated and DC-link voltage control to compensate the AC voltage deviation is proposed for the PV‒BESS system in low-voltage (LV networks.

  11. Experimental Study ofa New Operative Procedure for Non-Ischemic Dilated Cardiomyopathy-Overlapping Cardiac Volume Reduction Operation

    Institute of Scientific and Technical Information of China (English)

    罗滨; 孟春营; 温定国; 松居喜朗; 安田庆秀

    2003-01-01

    Objectives To assess anewly devised procedure of cardiac volume reduction without resection of cardiac muscle and evaluated in experimental settings. Methods Ten beagle dogs underwent a rapid pacing leading to heart failure for 3 weeks and received the left ventricular reduction termed overlapping cardiac volume reduction operation (OLCVR) ,which consisted of a longitudinal incision in left ventricular (LV) free wall, sutures of the left marginal to the septal wall, and the right marginal to LV free wall.A slope of the linear preload recruitable stroke work relationship (Mw) , with a X - intercept (Vo) were calculated as the precise indicators of left ventricular systolic function. The constant of isovolumic pressure decay (Tau) and a peak filling rate (PFR) were also calculated as the indicators of LV diastolic function.Results LV end- diastolic dimensions was significantly reduced by OLCVR (43±2 to 25±1; mm).Fractional shortening was significantly improved by OLCVR (11±2 to 30±4;%). Mw (erg* cm-3* 103)was also significantly improved (21±2 to 33 ±3 (p<0. 001 ) ) , whereas Vo, Tau and PFR did not show significant changes. Conclusions The OLCVR significantly increased in the early LV systolic function without detrimental effects on diastolic function. This procedure may become a therapeutic option for end - stage cardiomyopathy.

  12. Alterations in the interleukin-1/interleukin-1 receptor antagonist balance modulate cardiac remodeling following myocardial infarction in the mouse.

    Directory of Open Access Journals (Sweden)

    Antonio Abbate

    Full Text Available Healing after acute myocardial infarction (AMI is characterized by an intense inflammatory response and increased Interleukin-1 (IL-1 tissue activity. Genetically engineered mice lacking the IL-1 receptor (IL-1R1-/-, not responsive to IL-1 or the IL-1 receptor antagonist (IL-1Ra, enhanced response to IL-1 have an altered IL-1/IL-1Ra balance that we hypothesize modulates infarct healing and cardiac remodeling after AMI.IL-1R1-/- and IL-1Ra-/- male mice and their correspondent wild-types (WT were subjected to permanent coronary artery ligation or sham surgery. Infarct size (trichrome scar size, apoptotic cell death (TUNEL and left ventricular (LV dimensions and function (echocardiography were measured prior to and 7 days after surgery.When compared with the corresponding WT, IL-1R1-/- mice had significantly smaller infarcts (-25%, less cardiomyocyte apoptosis (-50%, and reduced LV enlargement (LV end-diastolic diameter increase [LVEDD], -20% and dysfunction (LV ejection fraction [LVEF] decrease, -50%, whereas IL-1Ra-/- mice had significantly larger infarcts (+75%, more apoptosis (5-fold increase, and more severe LV enlargement (LVEDD increase,+30% and dysfunction (LVEF decrease, +70%(all P values <0.05.An imbalance in IL-1/IL-1Ra signaling at the IL-1R1 level modulates the severity of cardiac remodeling after AMI in the mouse, with reduced IL-1R1 signaling providing protection and unopposed IL-1R1 signaling providing harm.

  13. Unexploited Dimensions of Virtual Humans

    NARCIS (Netherlands)

    Ruttkay, Zsófia; Reidsma, Dennis; Nijholt, Anton; Huang, Thomas; Nijholt, Anton; Pantic, Maja; Pentlant, Alex

    2007-01-01

    Virtual Humans are on the border of fiction and realism: while it is obvious that they do not exist in reality and function on different principles than real people, they have been endowed with human features such as being emotionally sensitive. In this article we argue that many dimensions, both hu

  14. Effective dimension in flocking mechanisms

    Science.gov (United States)

    Baglietto, Gabriel; Albano, Ezequiel V.

    2011-03-01

    Even in its minimal representation (Vicsek Model, VM [T. Vicsek, A. Czirok, E. Ben-Jacob, I. Cohen and O. Shochet. Phys. Rev. Lett. 75, 1226 (1995).]), the widespread phenomenon of flocking raises intriguing questions to the statistical physicists. While the VM is very close to the better understood XY Model because they share many symmetry properties, a major difference arises by the fact that the former can sustain long-range order in two dimensions, while the latter can not. Aiming to contribute to the understanding of this feature, by means of extensive numerical simulations of the VM, we study the network structure of clusters showing that they can also sustain purely orientational, mean-field-like, long-range order. We identify the reason of this capability with the key concept of "effective dimension." In fact, by analyzing the behavior of the average path length and the mean degree, we show that this dimension is very close to four, which coincides with the upper critical dimension of the XY Model, where orientational order is also of a mean-field nature. We expect that this methodology could be generalized to other types of dynamical systems.

  15. Cosmology With Dynamical Extra Dimensions

    CERN Document Server

    Erickson, J K

    2005-01-01

    Nearly every attempt to unify the fundamental forces incorporates the idea of compact extra dimensions. The notion was introduced by Kaluza and Klein in the 1920s and is an essential part of contemporary string theory and M-theory. In most treatments the extra dimensions are static. We consider the consequences of extra dimensions with time-varying radii. The radii are modeled by light scalar fields. These may have unusual properties which produce observable effects, such as non-canonical kinetic energies, couplings to matter and radiation, and non- minimal coupling to gravity. Extra dimensions may be responsible for dark energy in the late universe. The simplest model of dark energy is characterized by its equation of state. We show that constraints placed on realistic models by the universality of free fall, variation of fundamental constants and metric tests of gravity are often stricter than bounds on the equation of state. Testing the equivalence principle maybe an effective way of distinguishing some qu...

  16. Competitive dimensions of human resources

    OpenAIRE

    Neykova Rumyana Mykolaivna; Prokopenko Olha Volodymyrіvna; Shcherbachenko Viktoriia Oleksiivna

    2015-01-01

    This article deals with the essence of human resources competitive dimensions. Their competitive priorities are analyzed in dynamic business environment, with an emphasis on the quality of human resources, their adaptive skills, communication skills and mobility. The attention is paid to the role behavior of personnel and the policies for its management in the context of cutting down management costs.

  17. Manual tracking in three dimensions.

    NARCIS (Netherlands)

    Mrotek, L.A.; Gielen, C.C.A.M.; Flanders, M.

    2006-01-01

    Little is known about the manual tracking of targets that move in three dimensions. In the present study, human subjects followed, with the tip of a hand-held pen, a virtual target moving four times (period 5 s) around a novel, unseen path. Two basic types of target paths were used: a peanut-shaped

  18. Dimensions of problem based learning

    DEFF Research Database (Denmark)

    Nielsen, Jørgen Lerche; Andreasen, Lars Birch

    2013-01-01

    The article contributes to the literature on problem based learning and problem-oriented project work, building on and reflecting the experiences of the authors through decades of work with problem-oriented project pedagogy. The article explores different dimensions of problem based learning...

  19. Quantum Gravity in Two Dimensions

    DEFF Research Database (Denmark)

    Ipsen, Asger Cronberg

    The topic of this thesis is quantum gravity in 1 + 1 dimensions. We will focus on two formalisms, namely Causal Dynamical Triangulations (CDT) and Dy- namical Triangulations (DT). Both theories regularize the gravity path integral as a sum over triangulations. The difference lies in the class...

  20. Competitive dimensions of human resources

    Directory of Open Access Journals (Sweden)

    Neykova Rumyana Mykolaivna

    2015-02-01

    Full Text Available This article deals with the essence of human resources competitive dimensions. Their competitive priorities are analyzed in dynamic business environment, with an emphasis on the quality of human resources, their adaptive skills, communication skills and mobility. The attention is paid to the role behavior of personnel and the policies for its management in the context of cutting down management costs.

  1. New dimensions in cell migration

    NARCIS (Netherlands)

    Friedl, P.; Sahai, E.; Weiss, S.; Yamada, K.M.

    2012-01-01

    Studies of cell migration in three-dimensional (3D) cell culture systems and in vivo have revealed several differences when compared with cell migration in two dimensions, including their morphology and mechanical and signalling control. Here, researchers assess the contribution of 3D models to our

  2. Massive Gravity in Three Dimensions

    NARCIS (Netherlands)

    Bergshoeff, Eric A.; Hohm, Olaf; Townsend, Paul K.

    2009-01-01

    A particular higher-derivative extension of the Einstein-Hilbert action in three spacetime dimensions is shown to be equivalent at the linearized level to the (unitary) Pauli-Fierz action for a massive spin-2 field. A more general model, which also includes "topologically-massive" gravity as a speci

  3. Heat conduction in three dimensions

    Science.gov (United States)

    Danza, T. M.; Fesler, L. W.; Mongan, R. D.

    1980-01-01

    Multidimensional heat conduction program computes transient temperature history and steady state temperatures of complex body geometries in three dimensions. Emphasis is placed on type of problems associated with Space Shuttle thermal protection system, but program could be used in thermal analysis of most three dimensional systems.

  4. Emotion dimensions and formant position

    NARCIS (Netherlands)

    Goudbeek, M.B.; Goldman, J.P.; Scherer, K.R.; Uther, M.; Moore, R.; Cox, S.

    2009-01-01

    The influence of emotion on articulatory precision was investigated in a newly established corpus of acted emotional speech. The frequencies of the first and second formant of the vowels /i/, /u/, and /a/ was measured and shown to be significantly affected by emotion dimension. High arousal resulted

  5. Manual tracking in three dimensions.

    NARCIS (Netherlands)

    Mrotek, L.A.; Gielen, C.C.A.M.; Flanders, M.

    2006-01-01

    Little is known about the manual tracking of targets that move in three dimensions. In the present study, human subjects followed, with the tip of a hand-held pen, a virtual target moving four times (period 5 s) around a novel, unseen path. Two basic types of target paths were used: a peanut-shaped

  6. Quantum Gravity in Two Dimensions

    DEFF Research Database (Denmark)

    Ipsen, Asger Cronberg

    The topic of this thesis is quantum gravity in 1 + 1 dimensions. We will focus on two formalisms, namely Causal Dynamical Triangulations (CDT) and Dy- namical Triangulations (DT). Both theories regularize the gravity path integral as a sum over triangulations. The difference lies in the class...

  7. The Visuospatial Dimension of Writing

    Science.gov (United States)

    Olive, Thierry; Passerault, Jean-Michel

    2012-01-01

    The authors suggest that writing should be conceived of not only as a verbal activity but also as a visuospatial activity, in which writers process and construct visuospatial mental representations. After briefly describing research on visuospatial cognition, they look at how cognitive researchers have investigated the visuospatial dimension of…

  8. Strong metric dimension: A survey

    Directory of Open Access Journals (Sweden)

    Kratica Jozef

    2014-01-01

    Full Text Available The strong metric dimension has been a subject of considerable amount of research in recent years. This survey describes the related development by bringing together theoretical results and computational approaches, and places the recent results within their historical and scientific framework. [Projekat Ministarstva nauke Republike Srbije, br. 174010 i br. 174033

  9. Unexploited Dimensions of Virtual Humans

    NARCIS (Netherlands)

    Ruttkay, Z.M.; Reidsma, Dennis; Huang, Thomas; Nijholt, Antinus; Pantic, Maja; Pentlant, Alex

    Virtual Humans are on the border of fiction and realism: while it is obvious that they do not exist in reality and function on different principles than real people, they have been endowed with human features such as being emotionally sensitive. In this article we argue that many dimensions, both

  10. The Feeling Dimension in Reading.

    Science.gov (United States)

    Ediger, Marlow

    The feeling dimension of students cannot be ignored in teaching and learning situations. Feelings are there and must not be ignored. Reading stresses word recognition, comprehension of subject matter at diverse levels of complexity, and application of what has been learned. A major ingredient so frequently left out is student appreciation of the…

  11. Heat conduction in three dimensions

    Science.gov (United States)

    Danza, T. M.; Fesler, L. W.; Mongan, R. D.

    1980-01-01

    Multidimensional heat conduction program computes transient temperature history and steady state temperatures of complex body geometries in three dimensions. Emphasis is placed on type of problems associated with Space Shuttle thermal protection system, but program could be used in thermal analysis of most three dimensional systems.

  12. Soldering and Mass Generation in Four Dimensions

    CERN Document Server

    Banerjee, R; Banerjee, Rabin; Wotzasek, Clovis

    2000-01-01

    We propose bosonised expressions for the chiral Schwinger models in four dimensions. Then, in complete analogy with the two dimensional case, we show the soldering of two bosonised chiral Schwinger models with opposite chiralities to yield the bosonised Schwinger model in four dimensions. The implications of the Schwinger model or its chiral version, as known for two dimensions, thereby get extended to four dimensions.

  13. Cosmology with dynamical extra dimensions

    Science.gov (United States)

    Erickson, Joel K.

    Nearly every attempt to unify the fundamental forces incorporates the idea of compact extra dimensions. The notion was introduced by Kaluza and Klein in the 1920s and is an essential part of contemporary string theory and M-theory. In most treatments the extra dimensions are static. We consider the consequences of extra dimensions with time-varying radii. The radii are modeled by light scalar fields. These may have unusual properties which produce observable effects, such as non-canonical kinetic energies, couplings to matter and radiation, and non-minimal coupling to gravity. Extra dimensions may be responsible for dark energy in the late universe. The simplest model of dark energy is characterized by its equation of state. We show that constraints placed on realistic models by the universality of free fall, variation of fundamental constants and metric tests of gravity are often stricter than bounds on the equation of state. Testing the equivalence principle maybe an effective way of distinguishing some quintessence models from a cosmological constant. In certain dark energy models the speed of sound is much less than the speed of light. We calculate how this affects the cosmic microwave background and show that the speed of sound may be measurable, provided dark energy is sufficiently dense at decoupling. This is another possible signature of quintessence. Dynamical extra dimensions may have consequences for the early universe. In the cyclic model, the universe is described in terms of a series of contractions and expansions of an extra dimension. The big bang is preceded by a big crunch and quantum fluctuations of the scalar field produce structure in universe. We consider how the fluctuations evolve and build over many cycles and show that there are no observable instabilities or adverse effects. In the cyclic model extra dimensions act as both dark energy and as an agent to cause contraction and a big crunch. Previous theorems suggested that contraction

  14. Multiple dimensions of cardiopulmonary dyspnea

    Institute of Scientific and Technical Information of China (English)

    HAN Jiang-na; XIONG Chang-ming; YAO Wei; FANG Qiu-hong; ZHU Yuan-jue; CHENG Xian-sheng; Karel P Van de Woestijne

    2011-01-01

    Background The current theory of dyspnea perception presumes a multidimensional conception of dyspnea.However,its validity in patients with cardiopulmonary dyspnea has not been investigated.Methods A respiratory symptom checklist incorporating spontaneously reported descriptors of sensory experiences of breathing discomfort,affective aspects,and behavioral items was administered to 396 patients with asthma,chronic obstructive pulmonary disease (COPD),diffuse parenchymal lung disease,pulmonary vascular disease,chronic heart failure,and medically unexplained dyspnea.Symptom factors measuring different qualitative components of dyspnea were derived by a principal component analysis.The separation of patient groups was achieved by a variance analysis on symptom factors.Results Seven factors appeared to measure three dimensions of dyspnea:sensory (difficulty breathing and phase of respiration,depth and frequency of breathing,urge to breathe,wheeze),affective (chest tightness,anxiety),and behavioral (refraining from physical activity) dimensions.Difficulty breathing and phase of respiration occurred more often in COPD,followed by asthma (R2=0.12).Urge to breathe was unique for patients with medically unexplained dyspnea (R2=0.12).Wheeze occurred most frequently in asthma,followed by COPD and heart failure (R2=0.17).Chest tightness was specifically linked to medically unexplained dyspnea and asthma (R2=0.04).Anxiety characterized medically unexplained dyspnea (R2=0.08).Refraining from physical activity appeared more often in heart failure,pulmonary vascular disease,and COPD (R2=0.15).Conclusions Three dimensions with seven qualitative components of dyspnea appeared in cardiopulmonary disease and the components under each dimension allowed separation of different patient groups.These findings may serve as a validation on the multiple dimensions of cardiopulmonary dyspnea.

  15. 论吕碧城护生思想的产生原因%Reasons for LV Bicheng’ s Protecting Animals Thought

    Institute of Scientific and Technical Information of China (English)

    耿春晓

    2014-01-01

    At her early ages ,LV Bicheng advocated feminist movement and female educa-tion,while she devoted more to animal protecting activities at her middle age .There were pro-found thoughts for her choosing different life course ,including religion ,peace and civilization . The environment at that time ,domestically and abroad ,was also decisive .LV Bicheng made this decision with years of consideration .As a Buddhist ,it was her way of saving the chaotic society .%晚清著名女词人吕碧城早年致力于女权运动和兴办女学,中年后却致力于护生,从事动物保护运动。她之所以选择与早年不同的人生轨迹,其实包含了许多对于宗教、和平与文明的深刻思考,与当时的国内外形势有着密不可分的关系。这是吕碧城经过多年思考而得出的选择,是身为佛教徒的她对纷乱社会的拯救方式。

  16. Clinical Research on Use of Oxaliplcrtin in Combination with HCPT, LV and 5FU in a Regimen for Advanced Gastric Cancer

    Institute of Scientific and Technical Information of China (English)

    GuoqingHu; QiangFu; MaolinJin; JieLi; LiangxiPan; YuxianBai; HuaijinWang; JianweiZhang; DingYu

    2004-01-01

    OBJECTIVE To observe the effects and adverse reactions of a OXA-HCPT LV/5FU 3 regimen for patients with advanced gastric cancer.METHODS OHLF3 regimen: OXA 130 mg/m2iv d 1, HCPT6 mg/m2, iv d 1-5, LV 200 mg/m2iv 2 h followed by a 5FU 400 mg/m2 iv bolus and 5FU 600mg/m2 iv d 1-3, were given, every 21 days as 1 cycle. Assessment of the tumor was conducted after 3 cycles and the effective cases were confirmed after 4 weeks.RESULTS Among 39 patients, 36 were actually evaluable. Overall response rates (CR + PR} were 50%' the major adverse reactions were mild hematological toxicity, nausea and vomiting and peripheral nerve abnormalities.CONCLUSION The OHLF 3 regimen using OXA and HCPT is effective and results in mild toxicity when used in combined chemotherapy for advanced gastric cancer.

  17. Coinfection of Leishmania chagasi with Toxoplasma gondii, Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) in cats from an endemic area of zoonotic visceral leishmaniasis.

    Science.gov (United States)

    Sobrinho, Ludmila Silva Vicente; Rossi, Cláudio Nazaretian; Vides, Juliana Peloi; Braga, Eveline Tozzi; Gomes, Ana Amélia Domingues; de Lima, Valéria Marçal Félix; Perri, Sílvia Helena Venturoli; Generoso, Diego; Langoni, Hélio; Leutenegger, Christian; Biondo, Alexander Welker; Laurenti, Márcia Dalastra; Marcondes, Mary

    2012-06-08

    The aim of the present study was to determine the coinfection of Leishmania sp. with Toxoplasma gondii, Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) in a population of cats from an endemic area for zoonotic visceral leishmaniasis. An overall 66/302 (21.85%) cats were found positive for Leishmania sp., with infection determined by direct parasitological examination in 30/302 (9.93%), by serology in 46/302 (15.23%) and by both in 10/302 (3.31%) cats. Real time PCR followed by amplicon sequencing successfully confirmed Leishmania infantum (syn Leishmania chagasi) infection. Out of the Leishmania infected cats, coinfection with FIV was observed in 12/66 (18.18%), with T. gondii in 17/66 (25.75%) and with both agents in 5/66 (7.58%) cats. FeLV was found only in a single adult cat with no Leishmania infection. A positive association was observed in coinfection of Leishmania and FIV (p0.05). In conclusion, cats living in endemic areas of visceral leishmaniasis are significantly more likely to be coinfected with FIV, which may present confounding clinical signs and therefore cats in such areas should be always carefully screened for coinfections. Copyright © 2012 Elsevier B.V. All rights reserved.

  18. Assessment of the LV-C2 Stack Sampling Probe Location for Compliance with ANSI/HPS N13.1-1999

    Energy Technology Data Exchange (ETDEWEB)

    Glissmeyer, John A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Antonio, Ernest J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Flaherty, Julia E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-09-01

    This document reports on a series of tests conducted to assess the proposed air sampling location for the Hanford Tank Waste Treatment and Immobilization Plant (WTP) Low-Activity Waste (LAW) C2V (LV-C2) exhaust stack with respect to the applicable criteria regarding the placement of an air sampling probe. Federal regulations require that a sampling probe be located in the exhaust stack according to the criteria established by the American National Standards Institute/Health Physics Society (ANSI/HPS) N13.1-1999, Sampling and Monitoring Releases of Airborne Radioactive Substances from the Stack and Ducts of Nuclear Facilities. These criteria address the capability of the sampling probe to extract a sample that represents the effluent stream. The tests were conducted on the LV-C2 scale model system. Based on the scale model tests, the location proposed for the air sampling probe in the scale model stack meets the requirements of the ANSI/HPS N13.1-1999 standard for velocity uniformity, flow angle, gas tracer and particle tracer uniformity. Additional velocity uniformity and flow angle tests on the actual stack will be necessary during cold startup to confirm the validity of the scale model results in representing the actual stack.

  19. INTERDEPENDENCE BETWEEN RELATIONSHIP QUALITY DIMENSIONS

    Directory of Open Access Journals (Sweden)

    Mario Pepur

    2011-02-01

    Full Text Available Tourism-dependent economy, unfavourable structure of accommodation and hotel capacity, seasonality of business and liquidity problems indicate importance of the relationships between hotels and banks in Croatia. Since the capital investments in new and modern capacities are necessity, the quality of their relationship would determine the future of Croatian economy as a whole in the long run. Regarding the capital investments, it is crucially important that cooperation between the employees in both business entities is based on the satisfaction, trust and commitment. In this way, every potential uncertainty as a consequence of the entity’s actions could be minimized. In this paper, 356 tourist objects are hierarchically clustered according to the relationship quality dimensions for the purpose of testing the characteristics according to which the clusters significantly differentiate. Consequently, the interdependence between the observed relationship quality dimensions is examined.

  20. Double Semions in Arbitrary Dimension

    Science.gov (United States)

    Freedman, Michael H.; Hastings, Matthew B.

    2016-10-01

    We present a generalization of the double semion topological quantum field theory to higher dimensions, as a theory of {d-1} dimensional surfaces in a d dimensional ambient space. We construct a local Hamiltonian that is a sum of commuting projectors and analyze the excitations and the ground state degeneracy. Defining a consistent set of local rules requires the sign structure of the ground state wavefunction to depend not just on the number of disconnected surfaces, but also upon their higher Betti numbers through the semicharacteristic. For odd d the theory is related to the toric code by a local unitary transformation, but for even d the dimension of the space of zero energy ground states is in general different from the toric code and for even {d > 2} it is also in general different from that of the twisted {Z_2} Dijkgraaf-Witten model.

  1. Flavor Symmetries in Extra Dimensions

    CERN Document Server

    Aranda, A; Aranda, Alfredo

    2002-01-01

    We present a model of flavor based on a discrete local symmetry that reproduces all fermion masses and mixing angles both in the quark and lepton sectors. The particle content of the model is that of the standard model plus an additional flavon field. All the fields propagate in a fifth universal extra dimension and the flavor scale is associated with the cutoff of the 5D theory which is $\\sim 10$ TeV. The Yukawa matrices as well as the Majorana mass matrix for the neutrinos are generated by higher dimension operators involving the flavon field. When the flavon field acquires a vacuum expectation value it breaks the flavor symmetry and thus generates the Yukawa couplings. The model is consistent with the nearly bimaximal solution to the solar and atmospheric neutrino deficits.

  2. The social dimension of entrepreneurship

    DEFF Research Database (Denmark)

    Ulhøi, John Parm

    2005-01-01

    This paper proposes an integrative framework to conceptualize important social dimensions of entrepreneurship. The paper reviews and evaluates the current status of research dealing with entrepreneurship, social capital and trust. The proposed framework rests on the recognition that entrepreneurial...... activities are results of social interactions and mechanisms. In consequence, entrepreneurship cannot merely be understood in terms of 'personality characteristics' or in sterile economic terms. The paper addresses by concluding implications for practitioners and for research....

  3. The social dimensions of entrepreneurship

    DEFF Research Database (Denmark)

    Ulhøi, John Parm

    2005-01-01

    This paper proposes an integrative framework to conceptualize important social dimensions of entrepreneurship. The paper reviews and evaluates the current status of research dealing with entrepreneurship, social capital and trust. The proposed framework rests on the recognition that entrepreneurial...... activities are results of social interactions and mechanisms. In consequence, entrepreneurship cannot merely be understood in terms of "personality characteristics" or in sterile economic terms. In closing, the paper addresses implications for practitioners and for research. Udgivelsesdato: AUG...

  4. The social dimensions of entrepreneurship

    DEFF Research Database (Denmark)

    Ulhøi, John Parm

    2005-01-01

    activities are results of social interactions and mechanisms. In consequence, entrepreneurship cannot merely be understood in terms of "personality characteristics" or in sterile economic terms. In closing, the paper addresses implications for practitioners and for research. Udgivelsesdato: AUG......This paper proposes an integrative framework to conceptualize important social dimensions of entrepreneurship. The paper reviews and evaluates the current status of research dealing with entrepreneurship, social capital and trust. The proposed framework rests on the recognition that entrepreneurial...

  5. Open strategy: Dimensions, dilemmas, dynamics

    OpenAIRE

    Hautz, J; D. Seidl; Whittington, R.

    2016-01-01

    Responding to increasing practitioner and academic interest in Open Strategy, this article builds on recent theoretical and empirical studies in order to advance research in the following ways. We begin by developing a definition of Open Strategy that emphasizes variation along the two dimensions of transparency and inclusion, as well as the dilemmas and dynamics inherent in its practices. We identify five dilemmas in particular: those of process, commitment, disclosure, empowerment and escal...

  6. Performance appraisal: dimensions and determinants

    OpenAIRE

    2012-01-01

    The determinants of the dimensions that shape a formal system of performance appraisal are studied in relation to a sample of Spanish manufacturing establishments. In particular, the factors that influence the measures used to evaluate performance, the person who carries out such appraisal and its frequency are analysed. Our results show that the characteristics of the establishment exert a significant influence on the configuration of performance appraisal. Specifically, we find that the use...

  7. Læsningens sproglige dimension

    DEFF Research Database (Denmark)

    Mulvad, Ruth; Kabel, Kristine

    2007-01-01

    Flere af projekterne i Nationalt Videncenter for Læsning arbejder for at styrke læsning gennem et kombineret fokus på teksters sproglige dimension og på den pædagogiske kontekst, som teksterne indgår i. To af dem har som mål at designe et kompetenceløft for seminarieundervisere og at udvikle...

  8. Variations of The Fifth Dimension

    DEFF Research Database (Denmark)

    Jensen, Tine

    koncept for læring og leg, kaldet Femte Dimension, eller 5D, som er udviklet af professor Michael Cole og kol­leger i mere end 20 år på University of California, San Diego, Laboratory of Comparative Human Cognition. 5D er et forsknings-, og læringsfællesskab, som arbejder med udvikling af lokale ’sites...

  9. Wave equations in higher dimensions

    CERN Document Server

    Dong, Shi-Hai

    2011-01-01

    Higher dimensional theories have attracted much attention because they make it possible to reduce much of physics in a concise, elegant fashion that unifies the two great theories of the 20th century: Quantum Theory and Relativity. This book provides an elementary description of quantum wave equations in higher dimensions at an advanced level so as to put all current mathematical and physical concepts and techniques at the reader’s disposal. A comprehensive description of quantum wave equations in higher dimensions and their broad range of applications in quantum mechanics is provided, which complements the traditional coverage found in the existing quantum mechanics textbooks and gives scientists a fresh outlook on quantum systems in all branches of physics. In Parts I and II the basic properties of the SO(n) group are reviewed and basic theories and techniques related to wave equations in higher dimensions are introduced. Parts III and IV cover important quantum systems in the framework of non-relativisti...

  10. Wormholes leading to extra dimensions

    CERN Document Server

    Bronnikov, K A

    2016-01-01

    In 6D general relativity with a scalar field as a source of gravity, a new type of static wormhole solutions is presented: such wormholes connect our universe with a small 2D extra subspace with a universe where this extra subspace is large, and the whole space-time is effectively 6-dimensional. We consider manifolds with the structure M0 x M1 x M2 , where M0 is 2D Lorentzian space-time while each of M1 an M2 can be a 2-sphere or a 2-torus. After selecting possible asymptotic behaviors of the metric functions compatible with the field equations, we give two explicit examples of wormhole solutions with spherical symmetry in our space-time and toroidal extra dimensions. In one example, with a massless scalar field (it is a special case of a well-known more general solution), the extra dimensions have a large constant size at the "far end"; the other example contains a nonzero potential $V(\\phi)$ which provides a 6D anti-de Sitter asymptotic, where all spatial dimensions are infinite.

  11. Quantum irreversibility in arbitrary dimension

    Energy Technology Data Exchange (ETDEWEB)

    Anselmi, Damiano

    2000-02-14

    Some recent ideas are generalized from four dimensions to the general dimension n. In quantum field theory, two terms of the trace anomaly in external gravity, the Euler density G{sub n} and {open_square}{sup n/2-1}R, are relevant to the problem of quantum irreversibility. By adding the divergence of a gauge-invariant current, G{sub n} can be extended to a new notion of Euler density G-tilde{sub n}, linear in the conformal factor. We call it pondered Euler density. This notion relates the trace-anomaly coefficients a and a{sup '} of G{sub n} and {open_square}{sup n/2-1}R in a universal way (a=a{sup '}) and gives a formula expressing the total RG flow of a as the invariant area of the graph of the beta function between the fixed points. I illustrate these facts in detail for n=6 and check the prediction to the fourth-loop order in the phi (cursive,open) Greek{sup 3}-theory. The formula of quantum irreversibility for general n even can be extended to n odd by dimensional continuation. Although the trace anomaly in external gravity is zero in odd dimensions, I show that the odd-dimensional formula has a predictive content.

  12. Quantum irreversibility in arbitrary dimension

    CERN Document Server

    Anselmi, D

    2000-01-01

    Some recent ideas are generalized from four dimensions to the general dimension n. Two terms of the trace anomaly in external gravity, the Euler density G_n and Box^{n/2-1}R, are relevant to the problem of quantum irreversibility. By adding the divergence of a gauge-invariant current, G_n can be extended to a new notion of Euler density, linear in the conformal factor. We call it pondered Euler density. This notion relates the trace-anomaly coefficients a and a' of G_n and Box^{n/2-1}R in a universal way (a=a') and gives a formula expressing the total RG flow of a as the invariant area of the graph of the beta function between the fixed points. I illustrate these facts in detail for n=6 and check the prediction to the fourth-loop order in the phi^3-theory. The formula of quantum irreversibility for general n even can be extended to n odd by dimensional continuation. Although the trace anomaly in external gravity is zero in odd dimensions, I show that the odd-dimensional formula has a predictive content.

  13. Dimensions of Attractors in Pinched Skew Products

    Science.gov (United States)

    Gröger, M.; Jäger, T.

    2013-05-01

    We study dimensions of strange non-chaotic attractors and their associated physical measures in so-called pinched skew products, introduced by Grebogi and his coworkers in 1984. Our main results are that the Hausdorff dimension, the pointwise dimension and the information dimension are all equal to one, although the box-counting dimension is known to be two. The assertion concerning the pointwise dimension is deduced from the stronger result that the physical measure is rectifiable. Our findings confirm a conjecture by Ding, Grebogi and Ott from 1989.

  14. Dimensions of attractors in pinched skew products

    CERN Document Server

    Gröger, M

    2011-01-01

    We study dimensions of strange non-chaotic attractors and their associated physical measures in so-called pinched skew products, introduced by Grebogi and his coworkers in 1984. Our main results are that the Hausdorff dimension, the pointwise dimension and the information dimension are all equal to one, although the box-counting dimension is known to be two. The assertion concerning the pointwise dimension is deduced from the stronger result that the physical measure is rectifiable. Our findings confirm a conjecture by Ding, Grebogi and Ott from 1989.

  15. Toxoplasma gondii, Dirofilaria immitis, feline immunodeficiency virus (FIV), and feline leukemia virus (FeLV) infections in stray and pet cats (Felis catus) in northwest China: co-infections and risk factors.

    Science.gov (United States)

    Cong, Wei; Meng, Qing-Feng; Blaga, Radu; Villena, Isabelle; Zhu, Xing-Quan; Qian, Ai-Dong

    2016-01-01

    This study was conducted to estimate the prevalence of Toxoplasma gondii, Dirofilaria immitis, feline immunodeficiency virus (FIV), and feline leukemia virus (FeLV) infections among stray and pet cats in Lanzhou, northwest China, and to identify the influence of age, gender, and regions on seropositivity. T. gondii antibodies were examined in cat sera by the modified agglutination test (MAT). The circulating antigens of D. immitis and FeLV and specific antibodies to FIV were examined using kits commercially available. The overall prevalence of T. gondii, FIV, FeLV, and D. immitis was 19.34, 9.12, 11.33, and 3.04 %, respectively. For the genetic characterization of T. gondii genotypes in cats, genomic DNA was extracted from the seropositive cats and the T. gondii B1 gene was amplified using a semi-nested PCR. DNA samples giving positive B1 amplification were then genotyped using multilocus PCR-RFLP. Two T. gondii genotypes (ToxoDB#9 and ToxoDB#1) were identified. Results of the multivariate logistic regression analysis showed that older cats are more likely to be seropositive than juveniles for T. gondii, FIV, FeLV, and D. immitis. This is the first report of T. gondii genotypes in cats in northwest China. Moreover, the present study is the first study of retrovirus and D. immitis seroprevalence in cats in China. The results revealed that T. gondii, FIV, and FeLV infections are common in stray and pet cats in northwest China.

  16. Fits to Moment Measurements from B->Xc lv and B-> Xs gamma Decays using Heavy Quark Expansions in the Kinetic Scheme

    CERN Document Server

    Buchmüller, O L; Buchmueller, Oliver; Flaecher, Henning

    2006-01-01

    We present a fit to moment measurements of inclusive distributions in B->Xc lv and B->Xs gamma decays to extract values for the CKM matrix element |Vcb|, the b- and c- quark masses, and higher order parameters that appear in the Heavy Quark Expansion. The fit is carried out using theoretical calculations in the kinetic scheme and includes moment measurements of the BaBar, Belle, CDF, CLEO and DELPHI collaborations where correlation matrices have been published. We also derive values for the heavy quark distribution function parameters $m_b$ and $\\mu_{\\pi}^2$ in different theoretical schemes that can be used as input for the evaluation of the associated theory error on |Vub|.

  17. Association of left ventricular mechanical dyssynchrony with survival benefit from revascularization: a study of gated positron emission tomography in patients with ischemic LV dysfunction and narrow QRS

    Energy Technology Data Exchange (ETDEWEB)

    AlJaroudi, Wael [Imaging Institute, Heart and Vascular, Cleveland, OH (United States); Sydell and Arnold Miller Family Heart and Vascular Institute, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland, OH (United States); Alraies, M.C. [Cleveland Clinic, Department of Hospital Medicine, Cleveland, OH (United States); Hachamovitch, Rory; Jaber, Wael A.; Brunken, Richard; Cerqueira, Manuel D.; Marwick, Thomas [Imaging Institute, Heart and Vascular, Cleveland, OH (United States)

    2012-10-15

    LV mechanical dyssynchrony (LVMD) is a risk marker in narrow QRS cardiomyopathy, but its association with treatment outcome is not well defined. We determined the incremental prognostic value of LVMD in ischemic cardiomyopathy, and assessed its interaction with scar, myocardium in jeopardy and subsequent revascularization. Stress and rest {sup 82}Rb gated PET were performed in 486 consecutive patients (66 {+-} 11 years of age, 82 % men, LV ejection fraction 26 {+-} 6 %) with ischemic cardiomyopathy and QRS <120 ms. LVMD was determined as the standard deviation (SD) of the regional time to minimum volume on phase analysis of the gated PET scan. A propensity score was determined to adjust for nonrandomized referral after imaging to coronary artery bypass grafting (CABG). In a Cox proportional hazards model used to determine the association between measures of LVMD and survival time, CABG was included as a time-dependent covariate and the use of an implantable cardiac defibrillator (ICD) after imaging was modeled as a stratification factor. Over 1.9 {+-} 1.4 years, 96 patients (20 %) underwent CABG and 108 (22 %) died. LVMD was a predictor of mortality (HR 1.16. 95 % CI 1.03;1.30, per 10 increase in phase SD, p = 0.02) after adjusting for baseline covariates, prior ICD use, the use of postimaging CABG, and other imaging data. There was a significant interaction between phase SD and CABG. Nested Cox models showed that LVMD carried prognostic information incremental to clinical variables, ejection fraction and CABG. LVMD is an independent predictor of all-cause mortality in ischemic cardiomyopathy, and may identify patients with a differential survival benefit from CABG versus medical therapy. (orig.)

  18. MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis.

    Science.gov (United States)

    Johnson, Radia M; Papp, Eniko; Grandal, Ildiko; Kowalski, Paul E; Nutter, Lauryl; Wong, Raymond C C; Joseph-George, Ann M; Danska, Jayne S; Guidos, Cynthia J

    2014-06-01

    During V(D)J recombination of immunoglobulin genes, p53 and nonhomologous end-joining (NHEJ) suppress aberrant rejoining of DNA double-strand breaks induced by recombinase-activating genes (Rags)-1/2, thus maintaining genomic stability and limiting malignant transformation during B-cell development. However, Rag deficiency does not prevent B-cell leukemogenesis in p53/NHEJ mutant mice, revealing that p53 and NHEJ also suppress Rag-independent mechanisms of B-cell leukemogenesis. Using several cytogenomic approaches, we identified a novel class of activating mutations in Fms-like tyrosine kinase 3 (Flt3), a receptor tyrosine kinase important for normal hematopoiesis in Rag/p53/NHEJ triple-mutant (TM) B-cell leukemias. These mutant Flt3 alleles were created by complex genomic rearrangements with Moloney leukemia virus (MuLV)-related endogenous retroviral (ERV) elements, generating ERV-Flt3 fusion genes encoding an N-terminally truncated mutant form of Flt3 (trFlt3) that was transcribed from ERV long terminal repeats. trFlt3 protein lacked most of the Flt3 extracellular domain and induced ligand-independent STAT5 phosphorylation and proliferation of hematopoietic progenitor cells. Furthermore, expression of trFlt3 in p53/NHEJ mutant hematopoietic progenitor cells promoted development of clinically aggressive B-cell leukemia. Thus, repetitive MuLV-related ERV sequences can participate in aberrant end-joining events that promote development of aggressive B-cell leukemia. © 2014 Johnson et al.; Published by Cold Spring Harbor Laboratory Press.

  19. Search for extra space dimensions with ATLAS

    Indian Academy of Sciences (India)

    Ambreesh Gupta; ATLAS Collaboration

    2004-03-01

    If extra spatial dimensions were to exist, they could provide a solution to the hierarchy problem. The studies done by the ATLAS Collaboration on the sensitivity of the detector to various extra dimension models are reported in this document.

  20. NONHOMOGENEOUS HOPF EQUATIONS IN HIGHER DIMENSIONS

    Institute of Scientific and Technical Information of China (English)

    JIU QUANSEN

    1999-01-01

    The existence and uniqueness of the localclassical solution of nonhomogenuous Hopf equationsin higher dimensions are proved in this paper. Thissolution is obtained by vanishing the viscosity termof Burger's equations in higher dimensions.

  1. Personality dimensions and disorders in pathological gambling

    DEFF Research Database (Denmark)

    Odlaug, Brian Lawrence; Schreiber, Liana R N; Grant, Jon E

    2013-01-01

    This review presents the most current research in personality dimensions and disorders with respect to pathological gambling.......This review presents the most current research in personality dimensions and disorders with respect to pathological gambling....

  2. Noncentrosymmetric superconductors in one dimension

    Science.gov (United States)

    Samokhin, K. V.

    2017-02-01

    We study the fermionic boundary modes (Andreev bound states) in a time-reversal invariant one-dimensional superconductor. In the presence of a substrate, spatial inversion symmetry is broken and the electronic properties are strongly affected by an antisymmetric spin-orbit coupling. We assume an arbitrary even number of nondegenerate bands crossing the Fermi level. We show that there is only one possible pairing symmetry in one dimension, an analog of s -wave pairing. The zero-energy Andreev bound states are present if the sign of the gap function in an odd number of the bands is different from all other bands.

  3. Correlation dimension of complex networks

    CERN Document Server

    Lacasa, Lucas

    2012-01-01

    We propose a new measure to characterize the dimension of complex networks based on the ergodic theory of dynamical systems. This measure is derived from the correlation sum of a trajectory generated by a random walker navigating the network, and extends the classical Grassberger-Procaccia algorithm to the context of complex networks. The method is validated with reliable results for both synthetic networks and real-world networks such as the world air-transportation network or urban networks, and provides a computationally fast way for estimating the dimensionality of networks which only relies on the local information provided by the walkers.

  4. Flavor Models In Extra Dimensions

    CERN Document Server

    Valadez, J

    2005-01-01

    This thesis consists of implementing flavor symmetries in the context of extra dimensions. To the particle content of the Standard Model we add an additional scalar (flavon) field and we assume that all the fields propagate in the extra-dimensional space-time. When the flavon field acquires a vacuum expectation value the flavor symmetry is effectively broken thus generating the Yukawa textures associated with the particles. An specific model in 5D that reproduces all fermion masses, mixing angles and ratios is presented.

  5. Extended scaling in high dimensions

    Science.gov (United States)

    Berche, B.; Chatelain, C.; Dhall, C.; Kenna, R.; Low, R.; Walter, J.-C.

    2008-11-01

    We apply and test the recently proposed 'extended scaling' scheme in an analysis of the magnetic susceptibility of Ising systems above the upper critical dimension. The data are obtained by Monte Carlo simulations using both the conventional Wolff cluster algorithm and the Prokof'ev-Svistunov worm algorithm. As already observed for other models, extended scaling is shown to extend the high-temperature critical scaling regime over a range of temperatures much wider than that achieved conventionally. It allows for an accurate determination of leading and sub-leading scaling indices, critical temperatures and amplitudes of the confluent corrections.

  6. The fourth dimension simply explained

    CERN Document Server

    Manning, Henry P

    2005-01-01

    To remove the contents of an egg without puncturing its shell or to drink the liquor in a bottle without removing the cork is clearly unthinkable - or is it? Understanding the world of Einstein and curved space requires a logical conception of the fourth dimension.This readable, informative volume provides an excellent introduction to that world, with 22 essays that employ a minimum of mathematics. Originally written for a contest sponsored by Scientific American, these essays are so well reasoned and lucidly written that they were judged to merit publication in book form. Their easily unders

  7. Nonlinear Filtering in High Dimension

    Science.gov (United States)

    2014-06-02

    dimension cardV . Remark 4.9. In the language of statistical mechanics, we exploit the fact that the smoothing distribution Px(X0, . . . , Xn ∈ · |Y1...does the mixing property of the random field X imply the conditional mixing property of (X, Y )? It will be insightful to reformulate the problem in...edge observations in Example 7.17 is merely cosmetic: the same example can be reformulated in terms of vertex observations. Indeed, let us define the

  8. Cultural Dimensions Of Legal Discourse

    Directory of Open Access Journals (Sweden)

    Sierocka Halina

    2014-09-01

    Full Text Available Despite the intention for precision and accuracy, legal discourse is oftentimes complex, archaic and ambiguous - which gives rise to contentious interpretation. Moreover, little or no attention is paid to the cultural dimension of legal discourse, which plays a critical role in the translation and interpretation of legal texts, as well as in the application of law. This paper endeavours to illustrate the impact the culture, or, more precisely, legal culture has on the way legal texts are construed or translated and to present problems which arise in the interpretation, translation and application of law as a result of cultural diversities

  9. Low Dimension Semiconducting Composite Nanomaterials

    Institute of Scientific and Technical Information of China (English)

    WANG Mang; CHEN Hong-zheng; SUN Jing-zhi

    2004-01-01

    Recently, low dimension nanostructures have gained considerable attention due to their technological potential as unique types of nanoscale building blocks for future optoelectronic devices and systems. Semiconducting composite nanomaterials, which can combine the advantages of two or more components, have been the focus in the area of nanomaterials synthesis and device application.In this paper, we report our work on the preparation of composite nanomaterials based on CNTs.CNTs were coated by organic or inorganic species via novel and facile methods (Fig. 1 and Fig.2).These functional CNTs based composites show eminent prospects and opportunities for new applications in a wide variation of areas.

  10. Quantum cosmology near two dimensions

    Science.gov (United States)

    Bautista, Teresa; Dabholkar, Atish

    2016-08-01

    We consider a Weyl-invariant formulation of gravity with a cosmological constant in d -dimensional spacetime and show that near two dimensions the classical action reduces to the timelike Liouville action. We show that the renormalized cosmological term leads to a nonlocal quantum momentum tensor which satisfies the Ward identities in a nontrivial way. The resulting evolution equations for an isotropic, homogeneous universe lead to slowly decaying vacuum energy and power-law expansion. We outline the implications for the cosmological constant problem, inflation, and dark energy.

  11. Liberating Efimov physics from three dimensions

    OpenAIRE

    Nishida, Yusuke; Tan, Shina

    2011-01-01

    When two particles attract via a resonant short-range interaction, three particles always form an infinite tower of bound states characterized by a discrete scaling symmetry. It has been considered that this Efimov effect exists only in three dimensions. Here we review how the Efimov physics can be liberated from three dimensions by considering two-body and three-body interactions in mixed dimensions and four-body interaction in one dimension. In such new systems, intriguing phenomena appear,...

  12. Rings with finite Gorenstein injective dimension

    DEFF Research Database (Denmark)

    Holm, Henrik Granau

    2004-01-01

    In this paper we prove that for any associative ring R, and for any left R-module M with nite projective dimension, the Gorenstein injective dimension GidRM equals the usual injective dimension idRM. In particular, if GidRR is nite, then also idRR is nite, and thus R is Gorenstein (provided that R...

  13. DIMENSIONS FOR RANDOM SELF-CONFORMAL SETS

    Institute of Scientific and Technical Information of China (English)

    Liu Yanyan; Wu Jun

    2003-01-01

    A set is called regular if its Hausdorff dimension and upper box-counting dimension coincide.In this paper,we prove that the random self-conformal set is regular almost surely.Also we determine the dimensions for a class of random self-conformal sets.

  14. Speaker Identification Based on Fractal Dimensions

    Institute of Scientific and Technical Information of China (English)

    侯丽敏; 王朔中

    2003-01-01

    This paper discusses application of fractal dimensions to speech processing. Generalized dimensions of arbitrary orders and associated fractal parameters are used in speaker identification. A characteristic vactor based on these parameters is formed, and a recognition criterion definded in order to identify individual speakers. Experimental results show the usefulness of fractal dimensions in characterizing speaker identity.

  15. Spectral Dimension from Causal Set Nonlocal Dynamics

    CERN Document Server

    Belenchia, Alessio; Marciano, Antonino; Modesto, Leonardo

    2015-01-01

    We investigate the spectral dimension obtained from non-local continuum d'Alembertians derived from causal sets. We find a universal dimensional reduction to 2 dimensions, in all dimensions. We conclude by discussing the validity and relevance of our results within the broader context of quantum field theories based on these nonlocal dynamics.

  16. Development of tools to manage the operational monitoring and pre-design of the NPP-LV cycle; Desarrollo de herramientas para administrar el seguimiento operativo y el pre-diseno del ciclo de la CLV

    Energy Technology Data Exchange (ETDEWEB)

    Perusquia, R.; Arredondo S, C.; Hernandez M, J. L.; Montes T, J. L.; Castillo M, A.; Ortiz S, J. J., E-mail: raul.perusquia@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2015-09-15

    This paper presents the development of tools to facilitate the management so much, the operational monitoring of boiling water reactors (BWR) of the nuclear power plant of Laguna Verde (NPP-LV) through independent codes, and how to carry out the static calculations corresponding to process of optimized pre-design of the reference cycle next to current cycle. The progress and preliminary results obtained with the program SACal, developed at Instituto Nacional de Investigaciones Nucleares (ININ), central tool to achieve provide a management platform of the operational monitoring and pre-design of NPP-LV cycle are also described. The reached preliminary advances directed to get an Analysis center and automated design of fuel assembly cells are also presented, which together with centers or similar modules related with the fuel reloads form the key part to meet the targets set for the realization of a Management Platform of Nuclear Fuel of the NPP-LV. (Author)

  17. Long-term importance of right ventricular outflow tract patch function in patients with pulmonary regurgitation.

    Science.gov (United States)

    Puranik, Rajesh; Tsang, Victor; Lurz, Philip; Muthurangu, Vivek; Offen, Sophie; Frigiola, Alessandra; Norman, Wendy; Walker, Fiona; Bonhoeffer, Philip; Taylor, Andrew M

    2012-05-01

    Chronic pulmonary regurgitation (PR) has deleterious effects on right ventricular (RV) function in repaired tetralogy of Fallot (ToF). However, there are little data regarding right ventricular outflow tract (RVOT) contractile dysfunction in response to chronic PR and on both RV and LV volumes and function. We retrospectively identified consecutive patients with PR who were referred for magnetic resonance imaging quantification of "free PR" detected on echocardiography between 2003 and 2008. Patients had ToF and a transannular patch procedure (n = 30, 25.1 ± 1.2 years) or PR resulting from valvar pulmonary stenosis treated with surgical or percutaneous valvotomy (n = 30, 26.6 ± 1.8 years). The ToF and the PS groups were well matched for age at scan, age at repair surgery in ToF or initial valvotomy in PS, duration of exposure to PR, body surface area, heart rate, PR fraction, net forward pulmonary artery flow, and main and branch pulmonary artery dimensions. Severe PR fractions were identified in both groups (ToF: 40% ± 1% vs PS: 37% ± 2%, P = .2). Indexed RV and LV end-diastolic volumes were similar for both ToF and PS groups (RV end-diastolic volume index: 137 ± 6 mL/m(2) vs 128 ± 5 mL/m(2), P = .2, and LV end-diastolic volume index: 72 ± 2 mL/m(2) vs 67 ± 2 mL/m(2), P = .1, respectively). RV mass was also similar between groups (95 ± 5 g vs 81 ± 6 g, respectively, P = .08). However, indexed RV and LV end-systolic volumes were consistently higher in ToF when compared with PS (RV end-systolic volume index: 70 ± 5 mL/m(2) vs 54 ± 3 mL/m(2), P function in patients with ToF when compared with PS (RV ejection fraction: 52% ± 1.5% vs 59% ± 1%, P function were similar when only patients with contractile RV outflow tracts were compared. RV outflow tract patch dysfunction in repaired ToF is responsible for higher end-systolic volumes and thus lower global measures of ventricular systolic function. These findings were not evident in cases of PS treated with

  18. Grand Unification in Higher Dimensions

    CERN Document Server

    Hall, L J; Hall, Lawrence J.; Nomura, Yasunori

    2003-01-01

    We have recently proposed an alternative picture for the physics at the scale of gauge coupling unification, where the unified symmetry is realized in higher dimensions but is broken locally by a symmetry breaking defect. Gauge coupling unification, the quantum numbers of quarks and leptons and the longevity of the proton arise as phenomena of the symmetrical bulk, while the lightness of the Higgs doublets and the masses of the light quarks and leptons probe the symmetry breaking defect. Moreover, the framework is extremely predictive if the effective higher dimensional theory is valid over a large energy interval up to the scale of strong coupling. Precise agreement with experiments is obtained in the simplest theory --- SU(5) in five dimensions with two Higgs multiplets propagating in the bulk. The weak mixing angle is predicted to be sin^2theta_w = 0.2313 \\pm 0.0004, which fits the data with extraordinary accuracy. The compactification scale and the strong coupling scale are determined to be M_c \\simeq 5 x...

  19. Topological dimension and dynamical systems

    CERN Document Server

    Coornaert, Michel

    2015-01-01

    Translated from the popular French edition, the goal of the book is to provide a self-contained introduction to mean topological dimension, an invariant of dynamical systems introduced in 1999 by Misha Gromov. The book examines how this invariant was successfully used by Elon Lindenstrauss and Benjamin Weiss to answer a long-standing open question about embeddings of minimal dynamical systems into shifts. A large number of revisions and additions have been made to the original text. Chapter 5 contains an entirely new section devoted to the Sorgenfrey line. Two chapters have also been added: Chapter 9 on amenable groups and Chapter 10 on mean topological dimension for continuous actions of countable amenable groups. These new chapters contain material that have never before appeared in textbook form. The chapter on amenable groups is based on Følner’s characterization of amenability and may be read independently from the rest of the book. Although the contents of this book lead directly to several active ar...

  20. Duality Symmetry and Soldering in Different Dimensions

    CERN Document Server

    Banerjee, R

    1997-01-01

    We develop a systematic method of obtaining duality symmetric actions in different dimensions. This technique is applied for the quantum mechanical harmonic oscillator, the scalar field theory in two dimensions and the Maxwell theory in four dimensions. In all cases there are two such distinct actions. Furthermore, by soldering these distinct actions in any dimension a master action is obtained which is duality invariant under a much bigger set of symmetries than is usually envisaged. The concept of swapping duality is introduced and its implications are discussed. The effects of coupling to gravity are also elaborated. Finally, the extension of the analysis for arbitrary dimensions is indicated.

  1. Dimension variation prediction and control for composites

    Science.gov (United States)

    Dong, Chensong

    This dissertation presents a systematic study on the dimension variation prediction and control for polymer matrix fiber reinforced composites. A dimension variation model was developed for process simulation based on thermal stress analysis and finite element analysis (FEA). This model was validated against the experimental data, the analytical solutions and the data from literature. Using the FEA-based dimension variation model, the deformations of typical composite structures were studied and the regression-based dimension variation model was developed. The regression-based dimension variation model can significantly reduce computation time and provide a quick design guide for composite products with reduced dimension variations. By introducing the material modification coefficient, this comprehensive model can handle various fiber/resin types and stacking sequences. It eliminates the complicated, time-consuming finite element meshing and material parameter defining process. The deformation compensation through tooling design was investigated using the FEA-based and the regression-based dimension variation models. The structural tree method (STM) was developed to compute the assembly deformation from the deformations of individual components, as well as the deformation of general shape composite components. The STM enables rapid dimension variation analysis/synthesis for complex composite assemblies with the regression-based dimension variation model. Using the STM and the regression-based dimension variation model, design optimization and tolerance analysis/synthesis were conducted. The exploring work presented in this research provides a foundation to develop practical and proactive dimension control techniques for composite products.

  2. Sestrin2 protects the myocardium against radiation-induced damage

    Energy Technology Data Exchange (ETDEWEB)

    Zeng, Yue-Can; Chi, Feng; Xing, Rui; Gao, Song; Chen, Jia-Jia; Duan, Qiong-Yu; Sun, Yu-Nan; Niu, Nan; Tang, Mei-Yue; Wu, Rong [Shengjing Hospital of China Medical University, Department of Medical Oncology, Cancer Center, Shenyang (China); Zeng, Jing [University of Washington School of Medicine, Department of Radiation Oncology, Seattle, WA (United States); Wang, Hong-Mei [Nanfang Hospital of Southern Medical University, Department of Radiation Oncology, Guangzhou (China)

    2016-05-15

    The purpose of this study was to investigate the role of Sestrin2 in response to radiation-induced injury to the heart and on the cardiomyopathy development in the mouse. Mice with genetic deletion of the Sestrin2 (Sestrin2 knockout mice [Sestrin2 KO]) and treatment with irradiation (22 or 15 Gy) were used as independent approaches to determine the role of Sestrin2. Echocardiography (before and after isoproterenol challenge) and left ventricular (LV) catheterization were performed to evaluate changes in LV dimensions and function. Masson's trichrome was used to assess myocardial fibrosis. Immunohistochemistry and Western blot were used to detect the capillary density. After 22 or 15 Gy irradiation, the LV ejection fraction (EF) was impaired in wt mice at 1 week and 4 months after irradiation when compared with sham irradiation. Compared to wt mice, Sestrin2 KO mice had significant reduction in reduced LVEF at 1 week and 4 months after irradiation. A significant increase in LV end-diastolic pressure and myocardial fibrosis and a significant decrease in capillary density were observed in irradiation-wt mice, as well as in irradiation-Sestrin2 KO mice. Sestrin2 involved in the regulation of cardiomyopathy (such as myocardial fibrosis) after irradiation. Overexpression of Sestrin2 might be useful in limiting radiation-induced myocardial injury. (orig.)

  3. Low-level transcutaneous electrical stimulation of the auricular branch of vagus nerve ameliorates left ventricular remodeling and dysfunction by downregulation of matrix metalloproteinase 9 and transforming growth factor β1.

    Science.gov (United States)

    Wang, Zhuo; Yu, Lilei; Huang, Bing; Wang, Songyun; Liao, Kai; Saren, Gaowa; Zhou, Xiaoya; Jiang, Hong

    2015-04-01

    Vagus nerve stimulation improves left ventricular (LV) remodeling by downregulation of matrix metalloproteinase 9 (MMP-9) and transforming growth factor β1 (TGF-β1). Our previous study found that low-level transcutaneous electrical stimulation of the auricular branch of the vagus nerve (LL-TS) could be substituted for vagus nerve stimulation to reverse cardiac remodeling. So, we hypothesize that LL-TS could ameliorate LV remodeling by regulation of MMP-9 and TGF-β1 after myocardial infarction (MI). Twenty-two beagle dogs were randomly divided into a control group (MI was induced by permanent ligation of the left coronary artery, n = 8), an LL-TS group (MI with long-term intermittent LL-TS, n = 8), and a normal group (sham ligation without stimulation, n = 6). At the end of 6 weeks follow-up, LL-TS significantly reduced LV end-systolic and end-diastolic dimensions, improved ejection fraction and ratio of early (E) to late (A) peak mitral inflow velocity. LL-TS attenuated interstitial fibrosis and collagen degradation in the noninfarcted myocardium compared with the control group. Elevated level of MMP-9 and TGF-β1 in LV tissue and peripheral plasma were diminished in the LL-TS treated dogs. LL-TS improves cardiac function and prevents cardiac remodeling in the late stages after MI by downregulation of MMP-9 and TGF-β1 expression.

  4. Relevance of echocardiographic evaluation of right ventricular function in patients undergoing cardiac resynchronization therapy.

    Science.gov (United States)

    Scuteri, Lea; Rordorf, Roberto; Marsan, Nina Ajmone; Landolina, Maurizio; Magrini, Giulia; Klersy, Catherine; Frattini, Folco; Petracci, Barbara; Vicentini, Alessandro; Campana, Carlo; Tavazzi, Luigi; Ghio, Stefano

    2009-08-01

    Right ventricular (RV) dysfunction is a marker of poor prognosis in heart failure (HF) patients. It is still unclear whether RV function might influence response to cardiac resynchronization therapy (CRT). Forty-four consecutive patients with HF, large QRS, and either intraventricular or interventricular dyssynchrony underwent echocardiographic evaluation before, 1 month after, and 6 months after CRT. Response to CRT was considered in case of significant LV reverse remodeling, defined as the occurrence of LV end-systolic volume (LVESV) reduction > or =15% at 6 months. All echocardiographic indexes of baseline RV function and dimensions were significantly more impaired in nonresponders versus responders to CRT: tricuspid annular plane systolic excursion (TAPSE 15 +/- 4 mm vs 20 +/- 5 mm, P = 0.001), RV systolic pulmonary artery pressure (RVSP 39 +/- 14 mmHg vs 27 +/- 8 mmHg, P = 0.02), RV end-diastolic area (RVEDA 23 +/- 6 cm(2) vs 16 +/- 3 cm(2) P 14 mm. As compared to those with high TAPSE (n = 30), patients with low TAPSE (n = 14) were less likely to show LV reverse remodeling after CRT (76% vs 14%, P < 0.001). Our study suggests that RV function significantly affects response to CRT. Poor LV reverse remodeling occurs after CRT in patients with HF having severe RV dysfunction at baseline.

  5. Psychophysical dimensions of tactile perception of textures.

    Science.gov (United States)

    Okamoto, Shogo; Nagano, Hikaru; Yamada, Yoji

    2013-01-01

    This paper reviews studies on the tactile dimensionality of physical properties of materials in order to determine a common structure for these dimensions. Based on the commonality found in a number of studies and known mechanisms for the perception of physical properties of textures, we conclude that tactile textures are composed of three prominent psychophysical dimensions that are perceived as roughness/smoothness, hardness/softness, and coldness/warmness. The roughness dimension may be divided into two dimensions: macro and fine roughness. Furthermore, it is reasonable to consider that a friction dimension that is related to the perception of moistness/dryness and stickiness/slipperiness exists. Thus, the five potential dimensions of tactile perception are macro and fine roughness, warmness/coldness, hardness/softness, and friction (moistness/dryness, stickiness/slipperiness). We also summarize methods such as psychological experiments and mathematical approaches for structuring tactile dimensions and their limitations.

  6. Morphologic and functional abnormalities in patients with Ebstein's anomaly with cardiac magnetic resonance imaging: Correlation with tricuspid regurgitation.

    Science.gov (United States)

    Liu, Xi; Zhang, Qin; Yang, Zhi-Gang; Guo, Ying-Kun; Shi, Ke; Xu, Hua-Yan; Wen, Ling-Yi; Li, Rui; Chen, Jing

    2016-09-01

    The aim of this study was to assess the correlations of functional and dimensional parameters with the severity of tricuspid regurgitation in patients with Ebstein's anomaly (EA) by using cardiac magnetic resonance (CMR) imaging. Thirty-three patients with EA without previous cardiac surgery and 25 normal individuals were recruited and underwent both cardiac MR imaging and preoperative transthoracic echocardiography. The left ventricular (LV) functional parameters and dimensions of the right ventricle (RV) and LV were measured using 3.0-T cardiac MR imaging. Tricuspid regurgitation severity grading was estimated by echocardiography. The functional and dimensional parameters were compared between EA patients and controls using independent sample t-tests. Spearman's rank correlation was used to determine the correlations between the functional and dimensional parameters and tricuspid regurgitation. Receiver operating characteristic (ROC) analysis was used to predict tricuspid regurgitation severity using individual functional and dimensional parameters. Statistical analysis revealed significant differences in the functional and dimensional parameters between EA patients and controls. Within the EA group, tricuspid valve regurgitation negatively correlated well with the left ventricular ejection fraction (LVEF) (r=-0.558, p=0.001). The ratio of the right ventricular (functional right ventricle) end-diastolic dimension to the left ventricle end-diastolic dimension (RVEDD/LVEDD) in EA patients also correlated well with the severity of tricuspid valve regurgitation (r=0.492, p=0.004). Moreover, ROC analysis revealed that high sensitivity and specificity were obtained for predicting the severity of tricuspid valve regurgitation with LVEF (78.3%, 90.0%) and RVEDD/LVEDD (78.3%, 94.3%). In EA patients, the left and right ventricular functional and dimensional parameters from MRI correlated well with tricuspid regurgitation, which helped predict the severity of EA. Copyright

  7. Impact of the permanent ventricular pacing site on left ventricular function in children: a retrospective multicentre survey.

    Science.gov (United States)

    van Geldorp, Irene E; Delhaas, Tammo; Gebauer, Roman A; Frias, Patrick; Tomaske, Maren; Friedberg, Mark K; Tisma-Dupanovic, Svjetlana; Elders, Jan; Früh, Andreas; Gabbarini, Fulvio; Kubus, Petr; Illikova, Viera; Tsao, Sabrina; Blank, Andreas Christian; Hiippala, Anita; Sluysmans, Thierry; Karpawich, Peter; Clur, Sally-Ann; Ganame, Xavier; Collins, Kathryn K; Dann, Gisela; Thambo, Jean-Benoît; Trigo, Conceição; Nagel, Bert; Papagiannis, John; Rackowitz, Annette; Marek, Jan; Nürnberg, Jan-Hendrik; Vanagt, Ward Y; Prinzen, Frits W; Janousek, Jan

    2011-12-01

    Chronic right ventricular (RV) pacing is associated with deleterious effects on cardiac function. In an observational multicentre study in children with isolated atrioventricular (AV) block receiving chronic ventricular pacing, the importance of the ventricular pacing site on left ventricular (LV) function was investigated. Demographics, maternal autoantibody status and echocardiographic measurements on LV end-diastolic and end-systolic dimensions and volumes at age 1 year) for isolated AV block. LV fractional shortening (LVFS) and, if possible LV ejection fraction (LVEF) were calculated. Linear regression analyses were adjusted for patient characteristics. From 27 centres, 297 children were included, in whom pacing was applied at the RV epicardium (RVepi, n = 147), RV endocardium (RVendo, n = 113) or LV epicardium (LVepi, n = 37). LVFS was significantly affected by pacing site (p = 0.001), and not by maternal autoantibody status (p = 0.266). LVFS in LVepi (39 ± 5%) was significantly higher than in RVendo (33 ± 7%, p < 0.001) and RVepi (35 ± 8%, p = 0.001; no significant difference between RV-paced groups, p = 0.275). Subnormal LVFS (LVFS < 28%) was seen in 16/113 (14%) RVendo-paced and 21/147 (14%) RVepi-paced children, while LVFS was normal (LVFS ≥ 28%) in all LVepi-paced children (p = 0.049). These results are supported by the findings for LVEF (n = 122): LVEF was <50% in 17/69 (25%) RVendo- and in 10/35 (29%) RVepi-paced patients, while LVEF was ≥ 50% in 17/18 (94%) LVepi-paced patients. In children with isolated AV block, permanent ventricular pacing site is an important determinant of LV function, with LVFS being significantly higher with LV pacing than with RV pacing.

  8. Real-Time Three-Dimensional Echocardiography: Characterization of Cardiac Anatomy and Function—Current Clinical Applications and Literature Review Update

    Science.gov (United States)

    Velasco, Omar; Beckett, Morgan Q.; James, Aaron W.; Loehr, Megan N.; Lewis, Taylor G.; Hassan, Tahmin; Janardhanan, Rajesh

    2017-01-01

    Abstract Our review of real-time three-dimensional echocardiography (RT3DE) discusses the diagnostic utility of RT3DE and provides a comparison with two-dimensional echocardiography (2DE) in clinical cardiology. A Pubmed literature search on RT3DE was performed using the following key words: transthoracic, two-dimensional, three-dimensional, real-time, and left ventricular (LV) function. Articles included perspective clinical studies and meta-analyses in the English language, and focused on the role of RT3DE in human subjects. Application of RT3DE includes analysis of the pericardium, right ventricular (RV) and LV cavities, wall motion, valvular disease, great vessels, congenital anomalies, and traumatic injury, such as myocardial contusion. RT3DE, through a transthoracic echocardiography (TTE), allows for increasingly accurate volume and valve motion assessment, estimated LV ejection fraction, and volume measurements. Chamber motion and LV mass approximation have been more accurately evaluated by RT3DE by improved inclusion of the third dimension and quantification of volumetric movement. Moreover, RT3DE was shown to have no statistical significance when comparing the ejection fractions of RT3DE to cardiac magnetic resonance (CMR). Analysis of RT3DE data sets of the LV endocardial exterior allows for the volume to be directly quantified for specific phases of the cardiac cycle, ranging from end systole to end diastole, eliminating error from wall motion abnormalities and asymmetrical left ventricles. RT3DE through TTE measures cardiac function with superior diagnostic accuracy in predicting LV mass, systolic function, along with LV and RV volume when compared with 2DE with comparable results to CMR.

  9. Trading in Risk Dimensions (TRD)

    CERN Document Server

    Ingber, Lester

    2007-01-01

    Previous work, mostly published, developed two-shell recursive trading systems. An inner-shell of Canonical Momenta Indicators (CMI) is adaptively fit to incoming market data. A parameterized trading-rule outer-shell uses the global optimization code Adaptive Simulated Annealing (ASA) to fit the trading system to historical data. A simple fitting algorithm, usually not requiring ASA, is used for the inner-shell fit. An additional risk-management middle-shell has been added to create a three-shell recursive optimization/sampling/fitting algorithm. Portfolio-level distributions of copula-transformed multivariate distributions (with constituent markets possessing different marginal distributions in returns space) are generated by Monte Carlo samplings. ASA is used to importance-sample weightings of these markets. The core code, Trading in Risk Dimensions (TRD), processes Training and Testing trading systems on historical data, and consistently interacts with RealTime trading platforms at minute resolutions, but ...

  10. Anisotropic inflation from extra dimensions

    CERN Document Server

    Litterio, M; Amendola, L; Dyrek, A; Litterio, Marco; Amendola, Luca; Dyrek, Andrzej

    1995-01-01

    Vacuum multidimensional cosmological models with internal spaces being compact n-dimensional Lie group manifolds are considered. Products of 3-spheres and SU(3) manifold (a novelty in cosmology) are studied. It turns out that the dynamical evolution of the internal space drives an accelerated expansion of the external world (power law inflation). This generic solution (attractor in a phase space) is determined by the Lie group space without any fine tuning or arbitrary inflaton potentials. Matter in the four dimensions appears in the form of a number of scalar fields representing anisotropic scale factors for the internal space. Along the attractor solution the volume of the internal space grows logarithmically in time. This simple and natural model should be completed by mechanisms terminating the inflationary evolution and transforming the geometric scalar fields into ordinary particles.

  11. Anomalous dimension in semiclassical gravity

    CERN Document Server

    Alesci, Emanuele

    2011-01-01

    The description of the phase space of relativistic particles coupled to three-dimensional Einstein gravity requires momenta which are coordinates on a group manifold rather than on ordinary Minkowski space. The corresponding field theory turns out to be a non-commutative field theory on configuration space and a group field theory on momentum space. Using basic non-commutative Fourier transform tools we introduce the notion of non-commutative heat-kernel associated with the Laplacian on the non-commutative configuration space. We show that the spectral dimension associated to the non-commutative heat kernel varies with the scale reaching a non-integer value smaller than three for Planckian diffusion scales.

  12. Supergravity Fluxbranes in Various Dimensions

    CERN Document Server

    Chen, C M; Saffin, P M; Chen, Chiang-Mei; Gal'tsov, Dmitri V.; Saffin, Paul M.

    2002-01-01

    We investigate fluxbrane solutions to the Einstein-antisymmetric form-dilaton theory in arbitrary space-time dimensions for a transverse space of cylindrical topology $S^k\\times R^n$, corresponding to smeared and unsmeared solutions. A master equation for a single metric function is derived. This is a non-linear second-order ordinary differential equation admitting an analytic solution, singular at the origin, which serves as an attractor for globally regular solutions, whose existence is demonstrated numerically. For all fluxbranes of different levels of smearing the metric function diverges at infinity as the same power of the radial coordinate except for the maximally smeared case, where a global solution is known in closed form and can be obtained algebraically using U-duality. The particular cases of F6 and F3 fluxbranes in D=11 supergravity and fluxbranes in IIA, IIB supergravities are discussed.

  13. Robust large dimension terahertz cloaking

    CERN Document Server

    Liang, Dachuan; Han, Jiaguang; Yang, Yuanmu; Zhang, Shuang; Zhang, Weili

    2011-01-01

    Invisibility cloaking not only catches the human imagination, but also promises fascinating applications in optics and photonics. By manipulating electromagnetic waves with metamaterials, researchers have been able to realize electromagnetic cloaking in the microwave, terahertz and optical regimes. Nevertheless, the complex design and fabrication process, narrow bandwidth, and high intrinsic losses in the metamaterial-based cloaks have imposed intractable limitations on their realistic applications. Seeking new approaches to overcome these perceived disadvantages is in progress. Here by using uniform sapphire crystal, we demonstrate the first homogenous invisibility cloak functioning at terahertz frequencies. The terahertz invisibility device features a large concealed volume, low loss, and broad bandwidth. In particular, it is capable of hiding objects with a dimension nearly an order of magnitude larger than that of its lithographic counterpart, but without involving complex and time-consuming cleanroom pro...

  14. Psychological dimensions of Energy Conservation

    Directory of Open Access Journals (Sweden)

    Tonello, Graciela

    2012-12-01

    Full Text Available One of the most serious current environmental problems is the depletion of non renewable natural resources. The vast majority of our daily actions involve the consumption of energy and they increase the problem. Environmental psychology studies the psychological motivations that determine pro-ecological behaviour. In this context the aim of this review was to determine which psychological models and variables are better descriptors of residential energy conservation, comparing the predictive power of different models related to behaviour, residential consumption as well as to the acceptability of energy policies. Results suggest that energy saving is mainly linked to altruistic motivations, followed by egoistic reasons and in a minor way to environmental concerns. People would act according to these dimensions when contextual conditions are perceived as appropriate.

  15. [Temporal dimensions of suicide: hypothesis].

    Science.gov (United States)

    Carbonell-Camós, Eliseu

    2008-01-01

    In this article, the author examines the temporal dimensions of suicide by taking into account the multiple existing approaches-circadian physiology, psychiatric or sociological epidemiology of suicide-however promoting a socio-anthropological perspective. From this perspective, suicide is examined as a social phenomenon inscribed in time. By beginning with a concern that is characteristic of anthropology of time, knowingly the relation between time of nature and time of society, the author addresses a key issue of the study of suicide already elaborated by Durkheim, in the relation between change that is a basic expression of the passage of time and suicide. After presenting different scientific contributions on the subject, the author proposes an hypothesis allowing integration of the influence of time related to natural phenomenon (cosmobiological rhythms) and the relation of time to social phenomenon (politico-economic rhythms) in relation with suicide and this, according to Gabennesch's theory of "failed promises."

  16. Numerical relativity in higher dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Zilhao, Miguel; Herdeiro, Carlos [Departamento de Fisica e Centro de Fisica do Porto, Faculdade de Ciencias da Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto (Portugal); Witek, Helvi; Cardoso, Vitor; Nerozzi, Andrea [Centro Multidisciplinar de Astrofisica - CENTRA, Departamento de Fisica, Instituto Superior Tecnico - IST, Av. Rovisco Pais 1, 1049-001 Lisboa (Portugal); Sperhake, Ulrich [California Institute of Technology, Pasadena, CA 91109 (United States); Gualtieri, Leonardo, E-mail: mzilhao@fc.up.p, E-mail: helvi.witek@ist.utl.p, E-mail: vitor.cardoso@ist.utl.p, E-mail: Leonardo.Gualtieri@roma1.infn.i, E-mail: crherdei@fc.up.p, E-mail: andrea.nerozzi@ist.utl.p, E-mail: sperhake@tapir.caltech.ed [Dipartimento di Fisica, Universita di Roma ' Sapienza' and Sezione, INFN Roma1, P.A. Moro 5, 00185, Roma (Italy)

    2010-05-01

    We give a status report on our project targeted at performing numerical simulations of a head-on collision of non-spinning black holes in higher dimensional non-compact space-times. These simulations should help us understand black objects in higher dimensions and their stability properties. They are also relevant for the problem of black hole formation and evaporation in particle accelerators and cosmic rays. We use the symmetries of the system to reduce the problem to an effective 3+1 problem, allowing the use of existing numerical codes. As a simple application of the formalism, we present the results for the evolution of a five dimensional single black hole space-time.

  17. Accessible solitons of fractional dimension

    Energy Technology Data Exchange (ETDEWEB)

    Zhong, Wei-Ping, E-mail: zhongwp6@126.com [Department of Electronic and Information Engineering, Shunde Polytechnic, Guangdong Province, Shunde 528300 (China); Texas A& M University at Qatar, P.O. Box 23874, Doha (Qatar); Belić, Milivoj [Texas A& M University at Qatar, P.O. Box 23874, Doha (Qatar); Zhang, Yiqi [Key Laboratory for Physical Electronics and Devices of the Ministry of Education & Shaanxi Key Lab of Information Photonic Technique, Xi’an Jiaotong University, Xi’an 710049 (China)

    2016-05-15

    We demonstrate that accessible solitons described by an extended Schrödinger equation with the Laplacian of fractional dimension can exist in strongly nonlocal nonlinear media. The soliton solutions of the model are constructed by two special functions, the associated Legendre polynomials and the Laguerre polynomials in the fraction-dimensional space. Our results show that these fractional accessible solitons form a soliton family which includes crescent solitons, and asymmetric single-layer and multi-layer necklace solitons. -- Highlights: •Analytic solutions of a fractional Schrödinger equation are obtained. •The solutions are produced by means of self-similar method applied to the fractional Schrödinger equation with parabolic potential. •The fractional accessible solitons form crescent, asymmetric single-layer and multilayer necklace profiles. •The model applies to the propagation of optical pulses in strongly nonlocal nonlinear media.

  18. The spatial dimensions of innovation

    DEFF Research Database (Denmark)

    Lorentzen, Anne

    2005-01-01

    The paper discusseses the spatial dimensions of innovation in Polish manufacturing companies. The conceptual framework of the paper is an understanding of social networks as a potential resource of the company, whether they are internal or external. Whether the company benefits from the potential...... of the networks (local, national international). Finally how can the network strategy of the companies be explained? What factors seem to determine an active involvement of networks and what other factors seem to explain a self-sufficient strategy of innovation? What is the spatial extension of the networks......, and are there systematic differences in the spatial extension of the networks? Does the transitional situation of the Polish society seem to favour certain strategies of innovation?...

  19. Human dimension of strategic partnerships

    Directory of Open Access Journals (Sweden)

    Petković Mirjana M.

    2004-01-01

    Full Text Available This paper aims to point to the widespread practice of neglecting behavioral aspects of different forms of fusions and integrations of enterprises that have emerged in the process of privatization through strategic partnerships with foreign companies among Serbian enterprises. The initial hypothesis in this paper is that the process of privatization, restructuring and transformation in Serbian enterprises cannot be completely successful and equally advantageous for all the subjects involved if there is no concern for human dimension of these processes. Without this concern there is a possibility for behavioral problems to arise, and the only way to resolve them is through post festum respecting and introducing elements that should never have been neglected in the first place. This paper refers to the phenomenon of collision of cultures and the ways of resolving it while forming strategic partnerships.

  20. Serre dimension of monoid algebras

    Indian Academy of Sciences (India)

    MANOJ K KESHARI; HUSNEY PARVEZ SARWAR

    2017-04-01

    Let $R$ be a commutative Noetherian ring of dimension $d$, $M$ a commutative cancellative torsion-free monoid of rank $r$ and $P$ a finitely generated projective $R[M]$-module of rank $t$ . Assume $M$ is $\\Phi$-simplicial seminormal. If $M \\in C(\\Phi)$, then Serre dim $R[M] \\leq d$. If $r \\leq 3$, then Serre dim $R[int(M)] \\leq d$. If $M \\subset \\mathbb{Z}^2_+$ is a normal monoid of rank 2, then Serre dim $R[M] \\leq d$. Assume $M$ is $c$-divisible, $d$ = 1 and $t \\geq 3$. Then$P \\cong \\wedge^{t} P \\oplus R[M]^{t−1}$. Assume $R$ is a uni-branched affine algebra over an algebraically closed field and $d$ = 1. Then $P \\cong \\wedge^{t} P \\oplus R[M]^{t−1}$.

  1. Grand unification in higher dimensions

    Science.gov (United States)

    Hall, Lawrence J.; Nomura, Yasunori

    2003-07-01

    We have recently proposed an alternative picture for the physics at the scale of gauge coupling unification, where the unified symmetry is realized in higher dimensions but is broken locally by a symmetry breaking defect. Gauge coupling unification, the quantum numbers of quarks and leptons and the longevity of the proton arise as phenomena of the symmetrical bulk, while the lightness of the Higgs doublets and the masses of the light quarks and leptons probe the symmetry breaking defect. Moreover, the framework is extremely predictive if the effective higher dimensional theory is valid over a large energy interval up to the scale of strong coupling. Precise agreement with experiments is obtained in the simplest theory— SU(5) in five dimensions with two Higgs multiplets propagating in the bulk. The weak mixing angle is predicted to be sin 2θw=0.2313±0.0004, which fits the data with extraordinary accuracy. The compactification scale and the strong coupling scale are determined to be M c≃5×10 14 GeV and M s≃1×10 17 GeV, respectively. Proton decay with a lifetime of order 10 34 years is expected with a variety of final states such as e+π0, and several aspects of flavor, including large neutrino mixing angles, are understood by the geometrical locations of the matter fields. When combined with a particular supersymmetry breaking mechanism, the theory predicts large lepton flavor violating μ→ e and τ→ μ transitions, with all superpartner masses determined by only two free parameters. The predicted value of the bottom quark mass from Yukawa unification agrees well with the data. This paper is mainly a review of the work presented in hep-ph/0103125, hep-ph/0111068, and hep-ph/0205067 [1-3].

  2. Quantum Physics in One Dimension

    Energy Technology Data Exchange (ETDEWEB)

    Logan, David [University of Oxford (United Kingdom)

    2004-05-14

    To a casual ostrich the world of quantum physics in one dimension may sound a little one-dimensional, suitable perhaps for those with an unhealthy obsession for the esoteric. Nothing of course could be further from the truth. The field is remarkably rich and broad, and for more than fifty years has thrown up innumerable challenges. Theorists, realising that the role of interactions in 1D is special and that well known paradigms of higher dimensions (Fermi liquid theory for example) no longer apply, took up the challenge of developing new concepts and techniques to understand the undoubted peculiarities of one-dimensional systems. And experimentalists have succeeded in turning pipe dreams into reality, producing an impressive and ever increasing array of experimental realizations of 1D systems, from the molecular to the mesoscopic - spin and ladder compounds, organic superconductors, carbon nanotubes, quantum wires, Josephson junction arrays and so on. Many books on the theory of one-dimensional systems are however written by experts for experts, and tend as such to leave the non-specialist a touch bewildered. This is understandable on both fronts, for the underlying theoretical techniques are unquestionably sophisticated and not usually part of standard courses in many-body theory. A brave author it is then who aims to produce a well rounded, if necessarily partial, overview of quantum physics in one dimension, accessible to a beginner yet taking them to the edge of current research, and providing en route a thorough grounding in the fundamental ideas, basic methods and essential phenomenology of the field. It is of course the brave who succeed in this world, and Thierry Giamarchi does just that with this excellent book, written by an expert for the uninitiated. Aimed in particular at graduate students in theoretical condensed matter physics, and assuming little theoretical background on the part of the reader (well just a little), Giamarchi writes in a

  3. Variation in turbidity with precipitation and flow in a regulated river system – river Göta Älv, SW Sweden

    Directory of Open Access Journals (Sweden)

    G. Göransson

    2013-07-01

    Full Text Available The turbidity variation in time and space is investigated in the downstream stretch of the river Göta Älv in Sweden. The river is heavily regulated and carries the discharge from the largest fresh water lake in Sweden, Lake Vänern, to the outflow point in Göteborg Harbour on the Swedish west coast. The river is an important waterway and serves as a fresh-water supply for 700 000 users. Turbidity is utilised as a water quality indicator to ensure sufficient quality of the intake water to the treatment plant. The overall objective of the study was to investigate the influence of rainfall, surface runoff, and river water flow on the temporal and spatial variability of the turbidity in the regulated river system by employing statistical analysis of an extensive data set. A six year long time series of daily mean values on precipitation, discharge, and turbidity from six stations along the river were examined primarily through linear correlation and regression analysis, combined with nonparametric tests and analysis of variance. The analyses were performed on annual, monthly, and daily bases, establishing temporal patterns and dependences, including; seasonal changes, impacts from extreme events, influences from tributaries, and the spatial variation along the river. The results showed that there is no simple relationship between discharge, precipitation, and turbidity, mainly due to the complexity of the runoff process, the regulation of the river, and the effects of Lake Vänern and its large catchment area. For the river Göta Älv, significant, positive correlations between turbidity, discharge, and precipitation could only be found during periods with high flow combined with heavy rainfall. Local precipitation does not seem to have any significant impact on the discharge in the main river, which is primarily governed by precipitation at catchment scale. The discharge from Lake Vänern determines the base level for the turbidity in the river

  4. [Occlusal vertical dimension in removable complete dentures].

    Science.gov (United States)

    den Haan, R; Witter, D J

    2011-12-01

    In removable complete dentures, the occlusal vertical dimension is an important factor for patients' satisfaction with aesthetics. An excessively reduced occlusal vertical dimension is especially likely to lead to complaints about aesthetics, whereas an increased occlusal vertical dimension may lead to discomfort and a decision not to wear the complete dentures. There are various methods for determining the occlusal vertical dimension in complete dentures, based on the vertical dimension in the rest position of the mandible or on phonetics. However, none of the methods have proven to be clearly superior, in terms of reliability, than the others. The assessment of the occlusal vertical dimension will become more reliable if several methods are used simultaneously. Moreover, knowledge of the characteristics of the ageing face is essential.

  5. Delimiting Maximal Kissing Configurations in Four Dimensions

    CERN Document Server

    Altschuler, Eric Lewin

    2013-01-01

    How many unit $n-$dimensional spheres can simultaneously touch or kiss a central $n-$dimensional unit sphere? Beyond mathematics this question has implications for fields such as cryptography and the structure of biologic and chemical macromolecules. The kissing number is only known for dimensions 1-4, 8 and 24 (2, 6, 12, 24, 240, 19650, respectively) and only particularly obvious for dimensions one and two. Indeed, in four dimensions it is not even known if Platonic polytope unique to that dimension known as the 24-cell is the unique kissing configuration. We have not been able to prove that the 24-cell is unique, but, using a physical approach utilizing the hopf map from four to three dimensions, we for the first time delimit the possible other configurations which could be kissing in four dimensions.

  6. The Deng algorithm in higher dimensions

    CERN Document Server

    Nyonyi, Y; Govinder, K S

    2014-01-01

    We extend an algorithm of Deng in spherically symmetric spacetimes to higher dimensions. We show that it is possible to integrate the generalised condition of pressure isotropy and generate exact solutions to the Einstein field equations for a shear-free cosmological model with heat flow in higher dimensions. Three new metrics are identified which contain results of four dimensions as special cases. We show graphically that the matter variables are well behaved and the speed of sound is causal.

  7. Climate Dimensions in E-Learning

    Directory of Open Access Journals (Sweden)

    Gyöngyi Bujdosó

    2008-05-01

    Full Text Available In designing organization and environment,climate is a conventional conception. By an observation of Halpin, climate means the same for organizations as personality for individuals.This paper introduces the concept of cyber climate and some climate dimensions in e-learning. We deal with some new cyber climate dimensions that should be observed during designing e-learning materials,and provides some other important climate dimensions that should be taken into account while designing digital learning environments.

  8. Spectral dimension flow on continuum random multigraph

    CERN Document Server

    Giasemidis, Georgios; Zohren, Stefan

    2012-01-01

    We review a recently introduced effective graph approximation of causal dynamical triangulations (CDT), the multigraph ensemble. We argue that it is well suited for analytical computations and that it captures the physical degrees of freedom which are important for the reduction of the spectral dimension as observed in numerical simulations of CDT. In addition multigraph models allow us to study the relationship between the spectral dimension and the Hausdorff dimension, thus establishing a link to other approaches to quantum gravity

  9. Exploring Extra Dimensions in Spectroscopy Experiments

    Institute of Scientific and Technical Information of China (English)

    LUO Feng; LIU Hong-Ya

    2006-01-01

    @@ We propose an idea in spectroscopy to search for extra spatial dimensions as well as to detect the possible deviation from Newton's inverse-square law at small scale, and we take high-Z hydrogenic systems and muonic atoms as illustrations. The relevant experiments might help to explore a more than two extra dimensions scenario in the brane world model proposed by Arkani-Hamed, Dimopoulos, Dvali (ADD) and to set constraints for fundamental parameters such as the size of extra dimensions.

  10. Effects of Benzalkonium Chloride, Proxel LV, P3 Hypochloran, Triton X-100 and DOWFAX 63N10 on anaerobic digestion processes.

    Science.gov (United States)

    Flores, German Antonio Enriquez; Fotidis, Ioannis A; Karakashev, Dimitar Borisov; Kjellberg, Kasper; Angelidaki, Irini

    2015-10-01

    In this study, the individual and synergistic toxicity of the following xenobiotics: Benzalkonium Chloride (BKC), Proxel LV (PRX), P3 Hypochloran (HPC), Triton X-100 (TRX), and DOWFAX 63N10 (DWF), on anaerobic digestion (AD) process, was assessed. The experiments were performed in batch and continuous (up-flow anaerobic sludge blanket, UASB) reactors with biochemical-industrial wastewater, as substrate. In batch experiments, half-maximal inhibitory concentrations (IC50) for the tested xenobiotics were found to be 13.1, 1003, 311.5 and 24.3 mg L(-1) for BKC, PRX, DWF and TRX, respectively while HPC did not affect the AD process. Furthermore, the xenobiotics mixture tested did not present any synergistic inhibitory effect on the AD process. In continuous experiments, BKC and xenobiotics' mixture induced even stronger (more than 85%) of inhibition, expressed as IC50, compared to the levels observed from the batch reactors. Oppositely, TRX showed no inhibition in continuous mode, while inhibition was detected at batch mode.

  11. Delivery of an engineered HGF fragment in an extracellular matrix-derived hydrogel prevents negative LV remodeling post-myocardial infarction.

    Science.gov (United States)

    Sonnenberg, Sonya B; Rane, Aboli A; Liu, Cassie J; Rao, Nikhil; Agmon, Gillie; Suarez, Sophia; Wang, Raymond; Munoz, Adam; Bajaj, Vaibhav; Zhang, Shirley; Braden, Rebecca; Schup-Magoffin, Pamela J; Kwan, Oi Ling; DeMaria, Anthony N; Cochran, Jennifer R; Christman, Karen L

    2015-03-01

    Hepatocyte growth factor (HGF) has been shown to have anti-fibrotic, pro-angiogenic, and cardioprotective effects; however, it is highly unstable and expensive to manufacture, hindering its clinical translation. Recently, a HGF fragment (HGF-f), an alternative c-MET agonist, was engineered to possess increased stability and recombinant expression yields. In this study, we assessed the potential of HGF-f, delivered in an extracellular matrix (ECM)-derived hydrogel, as a potential treatment for myocardial infarction (MI). HGF-f protected cardiomyocytes from serum-starvation and induced down-regulation of fibrotic markers in whole cardiac cell isolate compared to the untreated control. The ECM hydrogel prolonged release of HGF-f compared to collagen gels, and in vivo delivery of HGF-f from ECM hydrogels mitigated negative left ventricular (LV) remodeling, improved fractional area change (FAC), and increased arteriole density in a rat myocardial infarction model. These results indicate that HGF-f may be a viable alternative to using recombinant HGF, and that an ECM hydrogel can be employed to increase growth factor retention and efficacy.

  12. Extra dimensions at particle colliders

    Energy Technology Data Exchange (ETDEWEB)

    Dvergsnes, Erik Wolden

    2004-08-01

    This thesis consists of an introduction where we consider different aspects of theories involving extra dimensions, together with four research publications (Papers I-IV) attached at the end. The introductional chapters should serve as background material for better understanding the models on which the articles are based. In Chap. 4 we also present some plots not included in the papers. The topic of Papers I-III is graviton induced Bremsstrahlung. In Paper I we consider the contribution to this process from graviton exchange through gluon-gluon fusion at the LHC, compared to the QED background. Only final-state radiation is considered in Paper I, whereas in Paper II we extend this work to include also the quark-antiquark annihilation with graviton exchange, as well as initial-state radiation for both graviton and Standard Model exchange. Paper III is a study of graviton-induced Bremsstrahlung at e{sup +}e{sup -} colliders, including both initial- and final-state radiation. Paper IV is devoted to a study of the center-edge asymmetry at hadron colliders, an asymmetry which previously had been studied for e{sup +}e{sup -} colliders. The center-edge asymmetry can be used as a method of distinguishing between spin-1 and spin-2 exchange, something which will be of major importance if a signal is observed.

  13. Moving into the third dimension

    CERN Multimedia

    Alizée Dauvergne

    2010-01-01

    One detail at a time, digital 3-D models of CERN’s various machines are being created by the Integration Section in the Machines & Experimental Facilities Group (EN/MEF) . The work, which requires painstaking attention to detail on a colossal scale, facilitates improvements to existing accelerators and the design of new machines in the future.   Virtual representation of the LHC A complete digital mockup of the LHC in three dimensions already exists, including of course the tunnel, the machine systems including magnets and vacuum chambers, but also all of the various services such as cable ladders, piping systems and access control and so on. Only the colour and the texture of the surfaces betray that it is a mockup and not the real thing! The mockup of LINAC4 is finished too. The mockups for the SPS, ISOLDE and the entire PS complex, including transfer lines, are still being created. “Creating these 3-D mockups will allow us to work on forthcoming machine improvements, esp...

  14. Dimensions of vehicle sounds perception.

    Science.gov (United States)

    Wagner, Verena; Kallus, K Wolfgang; Foehl, Ulrich

    2017-10-01

    Vehicle sounds play an important role concerning customer satisfaction and can show another differentiating factor of brands. With an online survey of 1762 German and American customers, the requirement characteristics of high-quality vehicle sounds were determined. On the basis of these characteristics, a requirement profile was generated for every analyzed sound. These profiles were investigated in a second study with 78 customers using real vehicles. The assessment results of the vehicle sounds can be represented using the dimensions "timbre", "loudness", and "roughness/sharpness". The comparison of the requirement profiles and the assessment results show that the sounds which are perceived as pleasant and high-quality, more often correspond to the requirement profile. High-quality sounds are characterized by the fact that they are rather gentle, soft and reserved, rich, a bit dark and not too rough. For those sounds which are assessed worse by the customers, recommendations for improvements can be derived. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. The international dimensions of neuroethics.

    Science.gov (United States)

    Lombera, Sofia; Illes, Judy

    2009-08-01

    Neuroethics, in its modern form, investigates the impact of brain science in four basic dimensions: the self, social policy, practice and discourse. In this study, we analyzed a set of 461 peer-reviewed articles with neuroethics content, published by authors from 32 countries. We analyzed the data for: (1) trends in the development of international neuroethics over time, and (2) how challenges at the intersection of ethics and neuroscience are viewed in countries that are considered developed by International Monetary Fund (IMF) standards, and in those that are developing. Our results demonstrate a steady increase in global participation in neuroethics from 1989 to 2005, characterized by an increase in numbers of articles published specifically on neuroethics, journals publishing these articles, and countries contributing to the literature. The focus from all countries was on the practice of brain science and the amelioration of neurological disease. Indicators of technology creation and diffusion in developing countries were specifically correlated with increases in publications concerning policy implications of brain science. Neuroethics is an international endeavor and, as such, should be sensitive to the impact that context has on acceptance and use of technological innovation.

  16. Higgs Bosons in Extra Dimensions

    CERN Document Server

    Quiros, Mariano

    2015-01-01

    In this paper, motivated by the recent discovery of a Higgs-like boson at the LHC with a mass m_H\\simeq 126 GeV, we review different models where the hierarchy problem is solved by means of a warped extra dimension. In the Randall-Sundrum model electroweak observables provide very strong bounds on the mass of KK modes which motivates extensions to overcome this problem. Two extensions are briefly discussed. One particular extension is based on the deformation of the metric such that it strongly departs from the AdS_5 structure in the IR region while it goes asymptotically to AdS_5 in the UV brane. This model has the IR brane close to a naked metric singularity (which is outside the physical interval) characteristic of soft-walls constructions. The proximity of the singularity provides a strong wave-function renormalization for the Higgs field which suppresses the T and S parameters. The second class of considered extensions are based on the introduction of an extra gauge group in the bulk such that the custod...

  17. Fractal Dimension of Voice-Signal Waveforms

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The fractal dimension is one important parameter that characterizes waveforms. In this paper, we derive a new method to calculate fractal dimension of digital voice-signal waveforms. We show that fractal dimension is an efficient tool for speaker recognition or speech recognition. It can be used to identify different speakers or distinguish speech. We apply our results to Chinese speaker recognition and numerical experiment shows that fractal dimension is an efficient parameter to characterize individual Chinese speakers. We have developed a semiautomatic voiceprint analysis system based on the theory of this paper and former researches.

  18. Spherical Gravitating Systems of Arbitrary Dimension

    CERN Document Server

    Das, A

    2001-01-01

    We study spherically symmetric solutions to the Einstein field equations under the assumption that the space-time may possess an arbitrary number of spatial dimensions. The general solution of Synge is extended to describe systems of any dimension. Arbitrary dimension analogues of known four dimensional solutions are also presented, derived using the above scheme. Finally, we discuss the requirements for the existence of Birkhoff's theorems in space-times of arbitrary dimension with or without matter fields present. Cases are discussed where the assumptions of the theorem are considerably weakened yet the theorem still holds. We also discuss where the weakening of certain conditions may cause the theorem to fail.

  19. Effect of HPMC - E15 LV premium polymer on release profile and compression characteristics of chitosan/ pectin colon targeted mesalamine matrix tablets and in vitro study on effect of pH impact on the drug release profile.

    Science.gov (United States)

    Newton, A M J; Lakshmanan, Prabakaran

    2014-04-01

    The study was designed to investigate the in vitro dissolution profile and compression characteristics of colon targeted matrix tablets prepared with HPMC E15 LV in combination with pectin and Chitosan. The matrix tablets were subjected to two dissolution models in various simulated fluids such as pH 1.2, 6, 6.8, 7.2, 5.5. The fluctuations in colonic pH conditions during IBD (inflammatory bowel disease) and the nature of less fluid content in the colon may limit the expected drug release in the polysaccharide-based matrices when used alone. The Hydrophilic hydroxyl propyl methylcellulose ether premium polymer (HPMC E15 LV) of low viscosity grade was used in the formulation design, which made an excellent modification in physical and compression characteristics of the granules. The release studies indicated that the prepared matrices could control the drug release until the dosage form reaches the colon and the addition HPMC E15 LV showed the desirable changes in the dissolution profile by its hydrophilic nature since the colon is known for its less fluid content. The hydrophilic HPMC E15 LV allowed the colonic fluids to enter into the matrix and confirmed the drug release at the target site from a poorly water soluble polymer such as Chitosan and also from water soluble Pectin. The dramatic changes occurred in the drug release profile and physicochemical characteristics of the Pectin, Chitosan matrix tablets when a premium polymer HPMC E15 LV added in the formulation design in the optimized concentration. Various drug release mechanisms used for the examination of drug release characteristics. Drug release followed the combined mechanism of diffusion, erosion, swelling and polymer entanglement. In recent decade, IBD attracts many patents in novel treatment methods by using novel drug delivery systems.

  20. Origin of Everything and the 21 Dimensions of the Universe

    Science.gov (United States)

    Loev, Mark

    2009-03-01

    The Dimensions of the Universe correspond with the Dimensions of the human body. The emotion that is a positive for every dimension is Love. The negative emotion that effects each dimension are listed. All seven negative emotions effect Peace, Love and Happiness. 21st Dimension: Happiness Groin & Heart 20th Dimension: Love Groin & Heart 19th Dimension: Peace Groin & heart 18th Dimension: Imagination Wave Eyes Anger 17th Dimension: Z Wave / Closed Birth 16th Dimension: Electromagnetic Wave Ears Anger 15th Dimension: Universal Wave Skin Worry 14th Dimension: Lover Wave Blood Hate 13th Dimension: Disposal Wave Buttocks Fear 12th Dimension: Builder Wave Hands Hate 11th Dimension: Energy Wave Arms Fear 10th Dimension: Time Wave Brain Pessimism 9th Dimension: Gravity Wave Legs Fear 8th Dimension: Sweet Wave Pancreas Fear 7th Dimension: File Wave Left Lung Fear 6th Dimension: Breathing Wave Right Lung Fear 5th Dimension: Digestive Wave Stomach Fear 4th Dimension: Swab Wave Liver Guilt 3rd Dimension: Space Wave Face Sadness 2nd Dimension: Line Wave Mouth Revenge 1st Dimension: Dot Wave Nose Sadness The seven deadly sins correspond: Anger Hate Sadness Fear Worry Pessimism Revenge Note: Guilt is fear

  1. 全球化背景下核型创新网络竞争机制研究--基于改进LV-EG模型的仿真分析%Study on Competition Mechanism of Core-structure Innovation Network under the Circumstance of Globalization-A Simulation Study Based on LV-EG Model

    Institute of Scientific and Technical Information of China (English)

    孙冰; 姚洪涛

    2016-01-01

    在全球化背景下,核型创新网络在向全球创新网络演进的过程中面临多市场竞争和关键资源竞争的双重考验。首先构建全球市场环境下核型创新网络多层次竞合模型;其次,运用Lotka-Volterra模型和演化博弈模型分别剖析核心企业间的竞争关系和尾端企业间的竞合关系,并据此构建改进的LV-EG模型以分析尾端企业竞合关系对核心企业间竞争关系的作用机理;最后,运用matlab对改进的LV-EG模型进行仿真。仿真结果表明:核心企业的尾端企业报酬支付能力、创新产品生产能力、创新环境和网络结构对核型创新网络在全球范围内吸引优质企业并在全球市场环境中获取竞争优势具有重要影响。%Under the circumstance of globalization , core-structure innovation network faces dual challenge of multi-market competition and key resources competition in the process of development where the revolution of core -struc-ture innovation network is to global innovation network .Therefore , we firstly establish the model of core-structure innovation network ’ s multi-level coopetition under the global market environment .And then we expound core-firms’ competition and end-firms’ coopetition by applying and the Lotka-Volterra model and the evolutionary game model.Finally, we simulate and analyze this process by applying matlab software to the LV -EG model and come to the conclusion that core-firm’ s ability of paying to end-firms and production capacity of innovative products , the innovation environment and the network structure influence greatly on core -firms’ ability to attract end-firms from the global world and core-firms’ s competitive advantage under the global market environment .

  2. Dimensions of health system reform.

    Science.gov (United States)

    Frenk, J

    1994-01-31

    During recent years there has been a growth of worldwide interest in health system reform. Countries at all levels of economic development are engaged in a creative search for better ways of organizing and financing health care, while promoting the goals of equity, effectiveness, and efficiency. Together with economic, political, and ideological reasons, this search has been fueled by the need to find answers to the complexities posed by the epidemiologic transition, whereby many nations are facing the simultaneous burdens of old, unresolved problems and new, emerging challenges. In order to better understand reform attempts, it is necessary to develop a clear conception of the object of reform: the health system. This paper presents the health system as a set of relationships among five major groups of actors: the health care providers, the population, the state as a collective mediator, the organizations that generate resources, and the other sectors that produce services with health effects. The relationships among providers, population, and the state form the basis for a typology of health care modalities. The type and number of modalities present in a country make it possible to characterize its health system. In the last part, the paper proposes that health system reform operates at four policy levels: systemic, which deals with the institutional arrangements for regulation, financing, and delivery of services; programmatic, which specifies the priorities of the system, by defining a universal package of health care interventions; organizational, which is concerned with the actual production of services by focusing on issues of quality assurance and technical efficiency; and instrumental, which generates the institutional intelligence for improving system performance through information, research, technological innovation, and human resource development. The dimensions of reform offer a repertoire of policy options, which need to be enriched by cross

  3. Quantum Field Theory in (0 + 1) Dimensions

    Science.gov (United States)

    Boozer, A. D.

    2007-01-01

    We show that many of the key ideas of quantum field theory can be illustrated simply and straightforwardly by using toy models in (0 + 1) dimensions. Because quantum field theory in (0 + 1) dimensions is equivalent to quantum mechanics, these models allow us to use techniques from quantum mechanics to gain insight into quantum field theory. In…

  4. Quality Dimensions of Internet Search Engines.

    Science.gov (United States)

    Xie, M.; Wang, H.; Goh, T. N.

    1998-01-01

    Reviews commonly used search engines (AltaVista, Excite, infoseek, Lycos, HotBot, WebCrawler), focusing on existing comparative studies; considers quality dimensions from the customer's point of view based on a SERVQUAL framework; and groups these quality expectations in five dimensions: tangibles, reliability, responsiveness, assurance, and…

  5. A unified theory in higher dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Kapetanakis, D. (National Research Centre for the Physical Sciences Democritos, Athens (Greece)); Zoupanos, G. (European Organization for Nuclear Research, Geneva (Switzerland))

    1990-10-11

    We present a grand unified model defined in ten dimensions and based on the group SO(13). The model is dimensionally reduced over the non-simply-connected space (Su(3)/U(1)xU(1))/Z{sub 2} giving in four dimensions the standard model. (orig.).

  6. Representation dimension of m-replicated algebras

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Let A be a finite-dimensional hereditary algebra over an algebraically closed field and A(m) be the m-replicated algebra of A.We prove that the representation dimension of A(m) is at most 3,and that the dominant dimension of A(m) is at least m.

  7. Unconscious Evaluation of Faces on Social Dimensions

    Science.gov (United States)

    Stewart, Lorna H.; Ajina, Sara; Getov, Spas; Bahrami, Bahador; Todorov, Alexander; Rees, Geraint

    2012-01-01

    It has been proposed that two major axes, dominance and trustworthiness, characterize the social dimensions of face evaluation. Whether evaluation of faces on these social dimensions is restricted to conscious appraisal or happens at a preconscious level is unknown. Here we provide behavioral evidence that such preconscious evaluations exist and…

  8. The pointwise dimensions of Moran measures

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In this paper,we get the formulas of upper(lower) pointwise dimensions of some Moran measures on Moran sets in Rd under the strong separation condition.We also obtain formulas for the dimension of the Moran measures.Our results extend the known results of some self-similar measures and Moran measures studied by Cawley and Mauldin.

  9. Selforthogonal modules with finite injective dimension

    Institute of Scientific and Technical Information of China (English)

    黄兆泳

    2000-01-01

    The category consisting of finitely generated modules which are left orthogonal with a cotilting bimodule is shown to be functorially finite. The notion of left orthogonal dimension is introduced , and then a necessary and sufficient condition of selforthogonal modules having finite injective dimension and a characterization of cotilting modules are given.

  10. Selforthogonal modules with finite injective dimension

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The category consisting of finitely generated modules which are left orthogonal with a cotilting bimodule is shown to be functorially finite. The notion of left orthogonal dimension is introduced, and then a necessary and sufficient condition of selforthogonal modules having finite injective dimension and a characterization of cotilting modules are given.

  11. Dimensions of cookie-cutter-like sets

    Institute of Scientific and Technical Information of China (English)

    马际华; 饶辉; 文志英

    2001-01-01

    The cookie-cutter-like sets are defined as the limit sets of a sequence of classical cookiecutter mappings. By introducing Gibbs-like measures, we study the dimensions, Hausdorff and packing measures of the CC-like sets, and then discuss the continuous dependence of the dimensions.

  12. Understanding Dimensions of Organizational Evaluation Capacity

    Science.gov (United States)

    Bourgeois, Isabelle; Cousins, J. Bradley

    2013-01-01

    Organizational evaluation capacity building has been a topic of increasing interest in recent years. However, the actual dimensions of evaluation capacity have not been clearly articulated through empirical research. This study sought to address this gap by identifying the key dimensions of evaluation capacity in Canadian federal government…

  13. Differential Krull dimension in differential polynomial extensions

    OpenAIRE

    Smirnov, Ilya

    2011-01-01

    We investigate the differential Krull dimension of differential polynomials over a differential ring. We prove a differential analogue of Jaffard's Special Chain Theorem and show that differential polynomial extensions of certain classes of differential rings have no anomaly of differential Krull dimension.

  14. A Note on Large Extra Dimensions

    OpenAIRE

    Akhoury, R.; van der Bij, J. J.

    2000-01-01

    We study corrections to the photon-propagator in a recently proposed model, where gravity lives in 4+n dimensions and Standard Model fields in 4 dimensions. We find a correction to the form factor of the photon that can be constrained by QED tests.

  15. [Vertical dimension in the Begg technic].

    Science.gov (United States)

    Demange, C; Dion, J G

    1989-01-01

    This data of 25 treated cases in BEGG technic show, with RICKETTS analysis, a small augmentation of vertical dimensions during treatment. During retention, four of five factors improved. No correlation have been found between increase rate of vertical dimensions, treatment duration, and initial typology.

  16. A new information dimension of complex networks

    Energy Technology Data Exchange (ETDEWEB)

    Wei, Daijun [School of Computer and Information Science, Southwest University, Chongqing 400715 (China); School of Science, Hubei University for Nationalities, Enshi 445000 (China); Wei, Bo [School of Computer and Information Science, Southwest University, Chongqing 400715 (China); Hu, Yong [Institute of Business Intelligence and Knowledge Discovery, Guangdong University of Foreign Studies, Guangzhou 510006 (China); Zhang, Haixin [School of Computer and Information Science, Southwest University, Chongqing 400715 (China); Deng, Yong, E-mail: ydeng@swu.edu.cn [School of Computer and Information Science, Southwest University, Chongqing 400715 (China); School of Engineering, Vanderbilt University, TN 37235 (United States)

    2014-03-01

    Highlights: •The proposed measure is more practical than the classical information dimension. •The difference of information for box in the box-covering algorithm is considered. •Results indicate the measure can capture the fractal property of complex networks. -- Abstract: The fractal and self-similarity properties are revealed in many complex networks. The classical information dimension is an important method to study fractal and self-similarity properties of planar networks. However, it is not practical for real complex networks. In this Letter, a new information dimension of complex networks is proposed. The nodes number in each box is considered by using the box-covering algorithm of complex networks. The proposed method is applied to calculate the fractal dimensions of some real networks. Our results show that the proposed method is efficient when dealing with the fractal dimension problem of complex networks.

  17. THE EQUALITY OF FRACTAL DIMENSION AND UNCERTAINTY DIMENSION FOR CERTAIN DYNAMIC-SYSTEMS

    NARCIS (Netherlands)

    NUSSE, HE; YORKE, JA

    1992-01-01

    [MGOY] introduced the uncertainty dimension as a quantative measure for final state sensitivity in a system. In [MGOY] and [P] it was conjectured that the box-counting dimension equals the uncertainty dimension for basin boundaries in typical dynamical systems. In this paper our main result is that

  18. THE EQUALITY OF FRACTAL DIMENSION AND UNCERTAINTY DIMENSION FOR CERTAIN DYNAMIC-SYSTEMS

    NARCIS (Netherlands)

    NUSSE, HE; YORKE, JA

    1992-01-01

    [MGOY] introduced the uncertainty dimension as a quantative measure for final state sensitivity in a system. In [MGOY] and [P] it was conjectured that the box-counting dimension equals the uncertainty dimension for basin boundaries in typical dynamical systems. In this paper our main result is that

  19. CADUCEUS, SCIPIO, ALCADIA: Cell therapy trials using cardiac-°©‐derived cells for patients with post myocardial infarction LV dysfunction, still evolving

    Directory of Open Access Journals (Sweden)

    Magdi H Yacoub

    2012-03-01

    Full Text Available The early results of the CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction study were recently published in the Lancet [1]. This study is a phase 1 prospective randomised study, performed at two centres. The study was designed to test the hypothesis that intracoronary infusion of autologous cardiac-derived cells following myocardial infarction can reduce the size of the infarct and increase the amount of viable myocardium. The eligible patients were randomised in a 2:1 ratio to receive CDCs or standard care. In all, 17 patients were randomised to cell therapy and 8 to standard care. The cell therapy consisted of an infusion of 25 million cells into the infarct related artery, 1.5–3 months after successful primary angioplasty in patients who developed LV dysfunction (EF less than 37 per cent. The cells were derived from RV endomyocardial biopsies performed within the previous 37 days. The number of cells was determined from previous experimental studies of the maximum number of cells which can be injected without inducing infarction. The study was not blinded because of ethical considerations regarding performing right ventricular biopsy on the controls. The exclusion criteria included patients who had evidence of right ventricular infarction, or could not have an MRI examination because of claustrophobia or prior insertion of devices. There was no death, myocardial infarction or serious arrhythmia reported in either group during the period of follow up, which was between 6-12 months. Serious adverse events were observed in 24 percent of the intervention group versus 12 per cent in the controls (p not significant.

  20. MFL-P Chemotherapy for Pretreated Metastatic Breast Cancer Patients: A Regimen with Triple Biochemical Modulation by MTX-5FU, LV-5FU and 5FU-CDDP.

    Science.gov (United States)

    Kan; Honda

    1999-07-25

    BACKGROUND: Chemotherapeutic regimens, such as cyclophosphamide + doxorubicin + 5FU (CAF) or cyclophosphamide + methotrexate + 5FU (CMF), are sometimes used in combination with endocrine or radiotherapy as a standard first line of treatment for recurrent or metastatic breast cancer. However, many cases are, or become, refractory to these treatments. METHODS: Twenty-one women with recurrent or metastatic breast cancer who previously underwent treatment were administered our original regimen of combinationchemotherapy, MFL-P: Day 1, bolus methotrexate (MTX) 50 mg/body (median dose, 33 mg/m(2); range, 29-35 mg/m(2)) and 4 hours later 5-fluorouracil (5FU) 750 mg/body/h (median dose, 497 mg/m(2)/h; range, 441-528 mg/m(2) /h); Days 2-3, bolus leucovorin(LV) 15 mg/body every 8 h x 3; Days 2-5, 72 hours continuous 5FU 750 mg/body/24h; Day 6, cisplatin (CDDP) 50 mg/body/h (median dose, 33 mg/m(2)/h; range, 29-35 mg/m(2) /h) with sufficient hydration. The subjects ranged in age from 26 to 63 years (mean age, 51.3 years). RESULTS: One complete and 9 partial responses were achieved among the 20 patients (response rate, 50%). In 1 patient, diffuse liver metastasis was not measurable. Among various metastatic sites, a higher response rate was observed especially for soft tissue lesions (skin, chest wall and lymph nodes; 9 responders among 11 lesions). On the other hand, in visceral or skeletal metastases, the response rate was poor. The adverse effects were tolerable in all patients, except for common low-grade stomatitis or anorexia. CONCLUSION: MFL-P is useful as a second or third line of therapy for patients with refractory, recurrent or metastatic breast cancer with soft tissues lesions.

  1. Alterações clínicas e hematológicas em gatos domésticos naturalmente infectados pelo Vírus da Leucemia Felina (FeLV

    Directory of Open Access Journals (Sweden)

    Nádia Rossi de Almeida

    2016-07-01

    Full Text Available O Vírus da Leucemia Felina (FeLV é um retrovírus imunossupressor e o maior causador de morte dentre as doenças infecciosas felinas. O FeLV induz ao desenvolvimento de distúrbios degenerativos e/ou mieloproliferativos nos animais infectados, que sucumbem à infecções oportunistas devido à imunossupressão. As alterações nos parâmetros hematológicos em gatos FeLV positivos muitas vezes não condizem com o estado clínico do animal, podendo o mesmo ser um portador assintomático apresentando alterações hematológicas, ou sintomático sem alterações nestes parâmetros. O objetivo do presente estudo foi avaliar as alterações nos parâmetros clínicos e hematológicos de gatos domésticos infectados naturalmente pelo FeLV, nas fases sintomáticas e assintomáticas da doença. Desta forma, foram selecionados 40 gatos domiciliados previamente testados como positivos para o FeLV pela técnica de imunofluorescência indireta. O exame físico foi realizado e os animais foram separados em dois grupos: os gatos sintomáticos e os assintomáticos para a infecção. Amostras de sangue para a realização de hemograma foram coletadas de ambos os grupos e o teste estatístico ANOVA foi realizado para a comparação das alterações hematológicas. O exame clínico indicou 37,5% dos gatos como portadores assintomáticos e 62,5% sintomáticos, sendo a perda de peso e alterações de mucosas os achados mais frequentes. O hemograma evidenciou anemia e linfopenia como os parâmetros hematológicos que apresentaram diferenças estatísticas entre os dois grupos estudados, sendo que 56% dos gatos assintomáticos apresentaram anemia. Em face aos resultados encontrados, concluiu-se que gatos FeLV positivos sintomáticos apresentaram alterações hematológicas condizentes com o quadro de imunossupressão clínico.

  2. Topological Hausdorff dimension and geodesic metric of critical percolation cluster in two dimensions

    Science.gov (United States)

    Balankin, Alexander S.; Mena, Baltasar; Martínez Cruz, M. A.

    2017-09-01

    In this work, we prove that the topological Hausdorff dimension of critical percolation cluster (CPC) in two dimensions is equal to DtH =Drb + 1 = 7 / 4, where Drb is the Hausdorff dimension of the set of red bonds. Hence, the CPC is infinitely ramified. We also argue that the mapping from the Euclidean metric to the geodesic metric on the CPC is governed by the Hausdorff dimension of the cluster skeleton Dsc =DH /dℓ >dmin, where DH, dℓ, and dmin are the Hausdorff and the connectivity (chemical) dimensions of the CPC and the fractal dimension of the minimum path, respectively. Then we introduce the notion of the topological connectivity dimension dtℓ. This allows us to establish the exact upper and lower bounds for the connectivity dimension dℓ of the CPC in d = 2. The upper and lower bounds for some other dimension numbers were established using the relations between dimension numbers. Narrow ranges defined by these bounds are much smaller than the error bars of numerical estimates reported in literature. Accordingly, the exact values of some dimension numbers are conjectured.

  3. Use of echocardiographic subxiphoid five-sixth area length (bullet method in evaluation of adequacy of borderline left ventricle in hypoplastic left heart complex

    Directory of Open Access Journals (Sweden)

    Justin T Tretter

    2015-01-01

    Full Text Available Indexed left ventricular end-diastolic volume (ILVEDV is commonly used in evaluating "borderline left ventricle (LV" in hypoplastic left heart complex (HLHC to determine if the LV can sustain adequate systemic cardiac output. Commonly used quantification methods include biplane Simpson or the traditional five-sixth area length "bullet" methods, which have been shown to underestimate true LV volumes, when septal position is mildly abnormal. Subxiphoid five-sixth area length method is proposed as a more accurate estimate of true LV volume in the evaluation of borderline LV.

  4. Abnormal glucose metabolism in acute myocardial infarction: influence on left ventricular function and prognosis

    DEFF Research Database (Denmark)

    Høfsten, Dan E; Løgstrup, Brian B; Møller, Jacob E

    2009-01-01

    tolerance test before discharge. LV function was assessed using echocardiographic measurements (LV end-diastolic volume, LV end-systolic volume, LV ejection fraction, restrictive diastolic filling pattern, early transmitral flow velocity to early diastolic mitral annular velocity ratio [E/e'], and left...... atrial volume index) and by measuring plasma N-terminal pro-B-type natriuretic peptide levels. RESULTS: After adjustment for age and gender, a linear relationship between the degree of abnormal glucose metabolism was observed for each marker of LV dysfunction (p(trend)

  5. Social dimensions of nuclear waste disposal

    Energy Technology Data Exchange (ETDEWEB)

    Grunwald, Armin [Karlsruhe Institute of Technology, Karlsruhe (Germany). Inst. for Technology Assessment and Systems Analysis

    2015-07-01

    Nuclear waste disposal is a two-faceted challenge: a scientific and technological endeavour, on the one hand, and confronted with social dimensions, on the other. In this paper I will sketch the respective social dimensions and will give a plea for interdisciplinary research approaches. Relevant social dimensions of nuclear waste disposal are concerning safety standards, the disposal 'philosophy', the process of determining the disposal site, and the operation of a waste disposal facility. Overall, cross-cutting issues of justice, responsibility, and fairness are of major importance in all of these fields.

  6. Questing mass dimension 1 spinor fields

    Energy Technology Data Exchange (ETDEWEB)

    Villalobos, C.H.C.; Hoff da Silva, J.M. [UNESP Universidade Estadual Paulista, Guaratingueta, SP CEP (Brazil); Rocha, Roldao da [CMCC, Universidade Federal do ABC, Santo Andre, SP (Brazil)

    2015-06-15

    This work deals with new classes of spinors of mass dimension 1 in Minkowski spacetime. In order to accomplish it, Lounesto's classification scheme and the inversion theorem are going to be used. The algebraic framework shall be revisited by explicating the central point performed by the Fierz aggregate. Then the spinor classification is generalized in order to encompass the new mass dimension 1 spinors. The spinor operator is shown to play a prominent role to engender the new mass dimension 1 spinors, accordingly. (orig.)

  7. Scaling dimensions in hidden Kerr/CFT

    CERN Document Server

    Lowe, David A; Skanata, Antun

    2011-01-01

    It has been proposed that a hidden conformal field theory (CFT) governs the dynamics of low frequency scattering in a general Kerr black hole background. We further investigate this correspondence by mapping higher order corrections to the massless wave equations in a Kerr background to an expansion within the CFT in terms of higher dimension operators. This implies the presence of infinite towers of CFT primary operators with positive conformal dimensions compatible with unitarity. The exact Kerr background softly breaks the conformal symmetry and the scaling dimensions of these operators run with frequency. The scale-invariant fixed point is dual to a degenerate case of flat spacetime.

  8. Projective Dimension in Filtrated K-Theory

    DEFF Research Database (Denmark)

    Bentmann, Rasmus Moritz

    2013-01-01

    any topological space with at most four points has projective dimension 2 or less. We observe that this implies a universal coefficient theorem for rational equivariant KK-theory over these spaces. As a contrasting example, we find a separable C∗dash-algebra in the bootstrap class over a certain five......-point space, the filtrated K-theory of which has projective dimension 3. Finally, as an application of our investigations, we exhibit Cuntz-Krieger algebras which have projective dimension 2 in filtrated K-theory over their respective primitive spectrum....

  9. A-type CpG ODN with higher binding affinity to LvToll1 could probably activate downstream IFN system-like antiviral response in shrimp Litopenaeus vannamei

    Directory of Open Access Journals (Sweden)

    J Xu

    2016-12-01

    Full Text Available CpG oligodeoxynucleotides (CpG ODNs is a widely used immune adjuvant, which could activate various immune responses including antiviral response through interaction with Toll-like receptor 9 (TLR9 in mammals. In the present study, four types of CpG ODN (CpG-A, CpG-B CpG-C, and CpG-P were synthesized and injected to the shrimp Litopenaeus vannamei in order to evaluate their immune enhancement effect in shrimp. The copy numbers of white spot syndrome virus in the shrimps treated with different types of CpG ODNs were of 3.10×105 (CpG-A, 8.32×105 (CpG-B, 9.84×105 (CpG-C, and 8.12×105 (CpG-P copies ng-1 DNA respectively, which were significantly lower (p < 0.01 than that in PBS group (1.70×106 copies ng-1 DNA. Surface plasmon resonance (SPR assay revealed that the four types of CpG ODN displayed different binding affinity to LvToll1, LvToll2 and LvToll3, and the highest binding affinity was observed between CpG-A and LvToll1. Correspondingly, the mRNA transcripts of LvTolls were up-regulated significantly in CpG-A stimulated shrimps,which was significantly higher than that in CpG-B, CpG-C and CpG-P groups (p < 0.01. The phagocytic rate and ROS level of shrimp hemocytes in CpG-A and CpG-B groups increased significantly compared with that in other groups, which were 1.63-fold, 9.98-fold (p < 0.01 in CpG-A and 1.60-fold, 4.92-fold (p < 0.01 in CpG-B higher than those in PBS group, respectively. Moreover, after CpG-A stimulation, the probable IFN level in shrimp plasma increased to 2.60-fold (p < 0.01 of that in PBS group, and the mRNA expressions of IFN system-like antiviral genes (LvIRF, LvVago4 and LvSTAT were also significantly up-regulated in CpG-A group, displaying a stronger response than that in CpG-B, CpG-C and CpG-P groups. The results indicated that CpG-A could promote the cellular and humoral immunity in shrimp, and induce relatively higher antiviral immune response among the four CpG ODNs. It provided useful information to understand

  10. Dynamical Decompactification and Three Large Dimensions

    CERN Document Server

    Greene, Brian; Marnerides, Stefanos

    2009-01-01

    We study string gas dynamics in the early universe and seek to realize the Brandenberger-Vafa mechanism - a goal that has eluded earlier works - that singles out three or fewer spatial dimensions as the number which grow large cosmologically. To this end, we consider a dilute gas of strings on a large torus, so that strings typically interact at significant impact parameters. A strong exponential suppression in the interaction rates for d>3 spatial dimensions reflects the classical argument that string worldsheets generically only intersect in four or fewer spacetime dimensions. As a consequence of this suppression, a scan over initial conditions establishes that in the dilute regime decompactification of d=3 spatial dimensions is favored over d>3.

  11. Human Dimensions Branch 2016 Annual Report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual report provides an overview of the work that the Human Dimensions Branch completed in FY2016, including a peak at: Monarch butterfly conservation and how...

  12. Dimensioning aids in practice. A comparison

    Energy Technology Data Exchange (ETDEWEB)

    Weinreich, Bernhard; Zehner, Mike

    2009-07-01

    State-of-the art dimensioning programmes can calculate almost everything - but can you also access these functions intuitively? On behalf of S and WE, Bernhard Weinreich and Mike Zehner have tested the handling of the most common programmes. (orig.)

  13. OPTIMAL PARTITIONS OF DATA IN HIGHER DIMENSIONS

    Data.gov (United States)

    National Aeronautics and Space Administration — OPTIMAL PARTITIONS OF DATA IN HIGHER DIMENSIONS BRADLEY W. JACKSON*, JEFFREY D. SCARGLE, AND CHRIS CUSANZA, DAVID BARNES, DENNIS KANYGIN, RUSSELL SARMIENTO, SOWMYA...

  14. Knowledge and cognitive process dimensions of Technology ...

    African Journals Online (AJOL)

    in their lesson plans according to knowledge and cognitive process dimensions. .... design skills to solve technological problems ... cation, Analysis, Synthesis, and Evaluation. ..... eaten away by chemical reactions or weather conditions, rather.

  15. Positive Gravitattional Energy in Arbitrary Dimensions

    CERN Document Server

    Choquet-Bruhat, Yvonne

    2011-01-01

    We present a streamlined, complete proof, valid in arbitrary space dimension $n$, and using only spinors on the oriented Riemannian space $(M^{n};g),$ of the positive energy theorem in General Relativity.

  16. European dimensions in Romanian Theological Discourse | Chirila ...

    African Journals Online (AJOL)

    European dimensions in Romanian Theological Discourse. ... Journal Home > Vol 65, No 1 (2009) > ... globalisation, with regard to which the author stresses the need for equilibrium between spiritual and scientific values and that Romanian

  17. STUDY OF CUSTOMERS’ LOYALTY: DIMENSIONS AND FACETS

    Directory of Open Access Journals (Sweden)

    Claudia BOBÂLCĂ

    2013-06-01

    Full Text Available The purpose of this study is to identify the main aspects investigated in the study of customer loyalty regarding different dimensions and facets of loyalty. Analyzing the academic literature on this subject, we identified two main directions: (a the approachings of loyalty on its dimensions (one, two or four dimensions; (b the approachings of loyalty on its facets (effects. The main facets of loyalty are repatronage intentions, word-of-mouth intentions and buying frequency. Our approach is a theoretical one and we used documentary research. Identifying and analyzing the dimensions and facets of loyalty are important stages for any loyalty program that a company should implement, regardless of its field of activity.

  18. Academic dimension of classroom learning environment and ...

    African Journals Online (AJOL)

    Academic dimension of classroom learning environment and students' nurses ... AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search · USING ... of their classroom academic environment and their attitude toward schooling.

  19. Identifying the Gender Dimension in Research Content

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, D.; Lalonde, B.St.L.; Tippett, C.; Archambault, E.; Callaert, J.; Mantouvalou, K.; Arora, L.

    2016-07-01

    Globally, there is an increasing interest in integrating the gender dimension in research content (GDRC). As a first step towards monitoring progress in this area, a new indicator measuring the proportion of a country’s scientific publications integrating a gender dimension in their subject matter was developed for the European Commission’s She Figures 2015 publication. This indicator is based on a keyword-based query covering both sex-related terms (biological characteristics of both women and men) and gender-related terms (social/cultural factors of both women and men). The final GDRC dataset consisted of some 212,600 distinct publications including a gender dimension in their research content. Findings suggest that integrating a gender dimension into research content is relatively rare. Unsurprisingly, it was less common for scientific articles in the fields of agricultural sciences, engineering and technology, and natural sciences to do so, and more common in the social sciences. (Author)

  20. Dimension of the boundary in different metrics

    CERN Document Server

    Klén, Riku

    2010-01-01

    On domains $\\Omega\\subset\\R^n$, we consider metrics induced by continuous densities $\\rho\\colon\\Omega\\rightarrow(0,\\infty)$ and study the Hausdorff and packing dimensions of the boundary of $\\Omega$ with respect to these metrics.

  1. Introducing the competitive dimension to corporate foresight

    DEFF Research Database (Denmark)

    Schwartz, Jan Oliver; Rohrbeck, René

    While the competitive dimension plays an important role in strategy, the aspect of competitors seems to be rather neglected in corporate foresight. In this paper we want to shed some more light on this underexplored field of corporate foresight. The literature review discusses approaches in corpo......While the competitive dimension plays an important role in strategy, the aspect of competitors seems to be rather neglected in corporate foresight. In this paper we want to shed some more light on this underexplored field of corporate foresight. The literature review discusses approaches...... or frameworks towards the competitive dimension in corporate foresight. In the paper an illustrative case study is discussed, with a first attempt to provide a framework for structuring the competitive dimension in corporate foresight....

  2. Dirac equations in n + 1 dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Jiang Yu [Departamento de FIsica, Universidad Autonoma Metropolitana-Iztapalapa, Apartado Postal 55-534, 09340 Mexico DF (Mexico)

    2005-02-04

    The Dirac equation in n + 1 dimensions is derived by a simple algebraic approach. The similarity in the structure of the arbitrary n-dimensional Dirac equations in a central field and their solutions is discussed.

  3. Measuring the dimension of partially embedded networks

    CERN Document Server

    Kondor, Dániel; Csabai, István; Vattay, Gábor

    2013-01-01

    Scaling phenomena have been intensively studied during the past decade in the context of complex networks. As part of these works, recently novel methods have appeared to measure the dimension of abstract and spatially embedded networks. In this paper we propose a new dimension measurement method for networks, which does not require global knowledge on the embedding of the nodes, instead it exploits link-wise information (link lengths, link delays or other physical quantities). Our method can be regarded as a generalization of the spectral dimension, that grasps the network's large-scale structure through local observations made by a random walker while traversing the links. We apply the presented method to synthetic and real-world networks, including road maps, the Internet infrastructure and the Gowalla geosocial network. We analyze the theoretically and empirically designated case when the length distribution of the links has the form P(r) ~ 1/r. We show that while previous dimension concepts are not appli...

  4. Ethical dimension of indigenous knowledge systems | Mutula ...

    African Journals Online (AJOL)

    Ethical dimension of indigenous knowledge systems. ... by way of social exclusion, linguistic marginalization, erosion of cultural identity, preference for ... The World Summit on Information Society (WSIS) provided an opportunity for indigenous ...

  5. Determinant factors of Yemeni maxillary arch dimensions

    Directory of Open Access Journals (Sweden)

    Nabil Muhsen Al-Zubair

    2015-01-01

    Conclusion: Measurements of palatal depth and relationships of the canines to one another and to other teeth thus had the widest ranges, implying that these dimensions are the strongest determinants of maxillary arch size.

  6. Spatiotemporal accessible solitons in fractional dimensions

    Science.gov (United States)

    Zhong, Wei-Ping; Belić, Milivoj R.; Malomed, Boris A.; Zhang, Yiqi; Huang, Tingwen

    2016-07-01

    We report solutions for solitons of the "accessible" type in globally nonlocal nonlinear media of fractional dimension (FD), viz., for self-trapped modes in the space of effective dimension 2 functions that include Gegenbauer polynomials, associated Laguerre polynomials, and associated Legendre functions. The validity of these solutions is verified by direct simulations. The model can be realized in various physical settings emulated by FD spaces; in particular, it applies to excitons trapped in quantum wells.

  7. String cosmology and the dimension of spacetime

    CERN Document Server

    Cleaver, G B; Gerald B Cleaver; Philip J Rosenthal

    1994-01-01

    The implications of string theory for understanding the dimension of uncompactified spacetime are investigated. Using recent ideas in string cosmology, a new model is proposed to explain why three spatial dimensions grew large. Unlike the original work of Brandenberger and Vafa, this paradigm uses the theory of random walks. A computer model is developed to test the implications of this new approach. It is found that a four-dimensional spacetime can be explained by the proper choice of initial conditions.

  8. String Cosmology and the Dimension of Spacetime

    OpenAIRE

    Cleaver, Gerald B.; Rosenthal, Philip J.

    1994-01-01

    The implications of string theory for understanding the dimension of uncompactified spacetime are investigated. Using recent ideas in string cosmology, a new model is proposed to explain why three spatial dimensions grew large. Unlike the original work of Brandenberger and Vafa, this paradigm uses the theory of random walks. A computer model is developed to test the implications of this new approach. It is found that a four-dimensional spacetime can be explained by the proper choice of initia...

  9. Quantum simulation of an extra dimension.

    Science.gov (United States)

    Boada, O; Celi, A; Latorre, J I; Lewenstein, M

    2012-03-30

    We present a general strategy to simulate a D+1-dimensional quantum system using a D-dimensional one. We analyze in detail a feasible implementation of our scheme using optical lattice technology. The simplest nontrivial realization of a fourth dimension corresponds to the creation of a bi-volume geometry. We also propose single- and many-particle experimental signatures to detect the effects of the extra dimension.

  10. The environmental dimension in the organisational sustainability

    OpenAIRE

    Pontes, Vera; Fonseca,Ana

    2008-01-01

    The concept of Sustainable Development in organisational context implies the integration of environmental and social concerns in company’s business operations. The main purpose of this work was to analyse published Sustainability Reports to evaluate the importance of the environmental dimension on the global sustainability strategy of Portuguese organisations. As main conclusions, the environmental dimension was found to be relevant in the management of Organisational Sustainabili...

  11. Sign (di)Lemma for Dimension Shifting

    Indian Academy of Sciences (India)

    Nitin Nitsure

    2009-04-01

    There is a surprising occurrence of some minus signs in the isomorphisms produced in the well-known technique of dimension shifting in calculating derived functors in homological algebra. We explicitly determine these signs. Getting these signs right is important in order to avoid basic contradictions. We illustrate the result – which we call as the sign lemma for dimension shifting – by some de Rham cohomology and Chern class considerations for compact Riemann surfaces.

  12. Exact Spectral Dimension of the Random Surface

    CERN Document Server

    Goncharenko, Igor

    2009-01-01

    We propose a new method of the analytical computation of the spectral dimension which is based on the equivalence of the random walk and the q-state Potts model with non-zero magnetic field in the limit $q\\to 0$. Calculating the critical exponent of the magnetization of this model on the dynamically triangulated random surface by means of a matrix model technique we obtain that the spectral dimension of this surface is equal to two.

  13. Quantum Gravity in D=5 Dimensions

    CERN Document Server

    Pinheiro, C; Pinheiro, Carlos

    2000-01-01

    We propose a topological Chern-Simons term in D=5 dimensions coupled to Einstein Hilbert theory. Hartree approximation for topological Lagrangian and the Chern-Simons term in D=3 is considered. An effective model of Quantum Gravity in D=5 dimensions is presented here. The analysis of residues is considered and the unitarity is guaranteed at tree level. The propagator is ghost and tachyon free.

  14. Editorial: Focus on Extra Space Dimensions

    Science.gov (United States)

    Agashe, Kaustubh; Pomarol, Alex

    2010-07-01

    Experiments at the Large Hadron Collider (LHC) have just started. In addition to verifying the Standard Model (SM) of particle physics, these experiments will probe a new energy frontier and test extensions of the SM. The existence of extra dimensions is one of the most attractive possibilities for physics beyond the SM. This focus issue contains a collection of articles addressing both theoretical and phenomenological aspects of extra-dimensional models. Focus on Extra Space Dimensions Contents Minimal universal extra dimensions in CalcHEP/CompHEP AseshKrishna Datta, Kyoungchul Kong and Konstantin T Matchev Disordered extra dimensions Karim Benakli Codimension-2 brane-bulk matching: examples from six and ten dimensions Allan Bayntun, C P Burgess and Leo van Nierop Gauge threshold corrections in warped geometry Kiwoon Choi, Ian-Woo Kim and Chang Sub Shin Holographic methods and gauge-Higgs unification in flat extra dimensions Marco Serone Soft-wall stabilization Joan A Cabrer, Gero von Gersdorff and Mariano Quirós Warped five-dimensional models: phenomenological status and experimental prospects Hooman Davoudiasl, Shrihari Gopalakrishna, Eduardo Pontón and José Santiago

  15. Brightness and darkness as perceptual dimensions.

    Directory of Open Access Journals (Sweden)

    Tony Vladusich

    2007-10-01

    Full Text Available A common-sense assumption concerning visual perception states that brightness and darkness cannot coexist at a given spatial location. One corollary of this assumption is that achromatic colors, or perceived grey shades, are contained in a one-dimensional (1-D space varying from bright to dark. The results of many previous psychophysical studies suggest, by contrast, that achromatic colors are represented as points in a color space composed of two or more perceptual dimensions. The nature of these perceptual dimensions, however, presently remains unclear. Here we provide direct evidence that brightness and darkness form the dimensions of a two-dimensional (2-D achromatic color space. This color space may play a role in the representation of object surfaces viewed against natural backgrounds, which simultaneously induce both brightness and darkness signals. Our 2-D model generalizes to the chromatic dimensions of color perception, indicating that redness and greenness (blueness and yellowness also form perceptual dimensions. Collectively, these findings suggest that human color space is composed of six dimensions, rather than the conventional three.

  16. Johnson Type Bounds on Constant Dimension Codes

    CERN Document Server

    Xia, Shu-Tao

    2007-01-01

    Very recently, an operator channel was defined by Koetter and Kschischang when they studied random network coding. They also introduced constant dimension codes and demonstrated that these codes can be employed to correct errors and/or erasures over the operator channel. Constant dimension codes are equivalent to the so-called linear authentication codes introduced by Wang, Xing and Safavi-Naini when constructing distributed authentication systems in 2003. In this paper, we study constant dimension codes. It is shown that Steiner structures are optimal constant dimension codes achieving the Wang-Xing-Safavi-Naini bound. Furthermore, we show that constant dimension codes achieve the Wang-Xing-Safavi-Naini bound if and only if they are certain Steiner structures. Then, we derive two Johnson type upper bounds, say I and II, on constant dimension codes. The Johnson type bound II slightly improves on the Wang-Xing-Safavi-Naini bound. Finally, we point out that a family of known Steiner structures is actually a fam...

  17. Antisocial behavior: Dimension or category(ies?

    Directory of Open Access Journals (Sweden)

    Biro Mikloš

    2008-01-01

    Full Text Available Classificatory systems (DSM-IV, ICD-10 use different criteria for defining a rather common antisocial disorder, traditionally referred as psychopathy. Most empirical studies of this phenomenon use Cleckley's operational definition that was applied and amended in Hare's revised Psychopathy Checklist (PCL-R. In modern literature, the fact that there is less than a perfect correspondence between classificatory systems and Hare's PCL-R is often cited as an indication that antisocial behavior is not confined to a distinct category of people but is rather a continuous personality dimension. In order to further elucidate the nosology of antisocial behaviors, a Psychopathy Assessment Questionnaire (PAQ based on Cleckley - Hare's criteria and consisting of 40 binary items was administered to 339 men (135 prisoners and 204 members of the general population. Four distinct clusters of respondents were identified by means of hierarchical cluster analysis: Psychopathic type (characterized by high positive scores on dimension of Unemotionality; Antisocial type (characterized by high positive scores on Social deviance dimension; Adapted type (characterized by negative scores on all dimensions; and Hyper-controlled type (characterized by extremely negative scores on dimension Social deviance accompanied with positive scores on Unemotionality dimension. Additional comparison with MMPI profiles which classified prison sample in two groups ("Psychopathic profiles" and "Non- Psychopathic profiles" shows that there is no expected compatibility between MMPI and PAQ. We conclude that Antisocial type can be treated as a distinct category, while Psychopathic type displays characteristics of dimensional distribution.

  18. Pathologic Manifestations on Surgical Biopsy and Their Correlation with Clinical Indices in Dogs with Degenerative Mitral Valve Disease.

    Science.gov (United States)

    Lee, J; Mizuno, M; Mizuno, T; Harada, K; Uechi, M

    2015-01-01

    Evaluation of myocardial function is clinically challenging in dogs with degenerative mitral valve disease (DMVD). Although myocardial dysfunction is caused by pathologic degeneration, histopathologic progression is poorly understood. To characterize myocardial and pulmonary pathologic changes according to severity in dogs with naturally occurring DMVD, and to investigate whether or not pathologic degeneration is reflected by traditional clinical indices. One hundred and seventeen dogs with naturally occurring DMVD. Prospective observational study. Biopsied left atrium (LA), left ventricle (LV), and lung were evaluated histologically, and an attempt was made to correlate pathologic findings with clinical indices. Severe myocardial changes were observed in all International Small Animal Cardiac Health Council classes. In the lung, heart failure cell levels were significantly increased in class III patients (P fibrosis (P < .0001). In contrast, myocardial cells were more hypertrophied in the LV than in the LA (P < .0001). Left ventricular end-diastolic dimension (LVEDd) was associated with fatty replacement (P = .033, R(2) = 0.584) and myocardial vacuolization (P = .003, R(2) = 0.588) in the LA. In DMVD, although severe pathologic changes may be evident even in early stages, there may be pathologic discrepancy between the LA and the LV. Myocardial degeneration may be reflected by clinical indices such as LVEDd and EF. Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

  19. Effects of buyang huanwu decoction on ventricular remodeling and differential protein profile in a rat model of myocardial infarction.

    Science.gov (United States)

    Zhou, Ying Chun; Liu, Bin; Li, Ying Jia; Jing, Lin Lin; Wen, Ge; Tang, Jing; Xu, Xin; Lv, Zhi Ping; Sun, Xue Gang

    2012-01-01

    Buyang Huanwu decoction (BYHWD) is a well-known and canonical Chinese medicine formula from "Correction on Errors in Medical Classics" in Qing dynasty. Here, we show that BYHWD could alleviate the ventricular remodeling induced by left anterior descending (LAD) artery ligation in rats. BYHWD treatment (18 g/kg/day) decreased heart weight/body weight (HW/BW), left ventricle (LV) dimension at end diastole (LVDd) and increased LV ejection fraction (LVEF) and LV fractional shortening (LVFS) significantly compared to model group at the end of 12 weeks. The collagen volume of BYHWD group was more significantly decreased than that of model group. Proteomic analysis showed that atrial natriuretic factor (ANF) was downregulated; heat shock protein beta-6 (HSPB6) and peroxiredoxin-6 (PRDX6) were upregulated in BYHWD-treated group among successfully identified proteins. The apoptotic index (AI) was reduced by BYHWD accompanied by decreased expression of Bax and caspase 3 activity, increased Bcl-2/Bax ratio, and phosphorylation of HSPB6 compared to that of model group. Taken together, these results suggest that BYHWD can alleviate ventricular remodeling induced by LAD artery ligation. The antiremodeling effects of BYHWD are conferred by decreasing AI through affecting multiple targets including increased Bcl-2/Bax ratio and decreased caspase 3 activity that might be via upregulated PRDX6, phosphorylation of HSPB6 and subsequently reduction of ANF.

  20. Effects of Buyang Huanwu Decoction on Ventricular Remodeling and Differential Protein Profile in a Rat Model of Myocardial Infarction

    Directory of Open Access Journals (Sweden)

    Ying Chun Zhou

    2012-01-01

    Full Text Available Buyang Huanwu decoction (BYHWD is a well-known and canonical Chinese medicine formula from “Correction on Errors in Medical Classics” in Qing dynasty. Here, we show that BYHWD could alleviate the ventricular remodeling induced by left anterior descending (LAD artery ligation in rats. BYHWD treatment (18 g/kg/day decreased heart weight/body weight (HW/BW, left ventricle (LV dimension at end diastole (LVDd and increased LV ejection fraction (LVEF and LV fractional shortening (LVFS significantly compared to model group at the end of 12 weeks. The collagen volume of BYHWD group was more significantly decreased than that of model group. Proteomic analysis showed that atrial natriuretic factor (ANF was downregulated; heat shock protein beta-6 (HSPB6 and peroxiredoxin-6 (PRDX6 were upregulated in BYHWD-treated group among successfully identified proteins. The apoptotic index (AI was reduced by BYHWD accompanied by decreased expression of Bax and caspase 3 activity, increased Bcl-2/Bax ratio, and phosphorylation of HSPB6 compared to that of model group. Taken together, these results suggest that BYHWD can alleviate ventricular remodeling induced by LAD artery ligation. The antiremodeling effects of BYHWD are conferred by decreasing AI through affecting multiple targets including increased Bcl-2/Bax ratio and decreased caspase 3 activity that might be via upregulated PRDX6, phosphorylation of HSPB6 and subsequently reduction of ANF.

  1. Role of common sarcomeric gene polymorphisms in genetic susceptibility to left ventricular dysfunction

    Indian Academy of Sciences (India)

    SURENDRA KUMAR; AVSHESH MISHRA; ANSHIKA SRIVASTAVA; MANSI BHATT; N. GARG; S. K. AGARWAL; SHANTANU PANDE; BALRAJ MITTAL

    2016-06-01

    Mutations in sarcomeric genes are common genetic cause of cardiomyopathies. An intronic 25-bp deletion in cardiac myosin binding protein C (MYBPC3) at 3' region is associated with dilated and hypertrophic cardiomyopathies in Southeast Asia. However, the frequency of sarcomeric gene polymorphisms and associated clinical presentation have not been established with left ventricular dysfunction (LVD). Therefore, the aim of the present study was to explore the association of MYBPC3 25-bp deletion, titin (TTN) 18 bp I/D, troponin T type 2 (TNNT2) 5 bp I/D and myospryn K2906N polymorphisms with LVD. This study includes 988 consecutive patients with angiographically confirmed coronary artery disease (CAD) and 300 healthy controls. Among the 988 CAD patients, 253 with reduced left ventricle ejection fraction (LVEF≤45%) were categorized as LVD. MYBPC3 25-bp deletion,TTN 18 bp I/D and TNNT25 bp I/D polymorphisms were determined by direct polymerase chain reaction method, while myospryn K2906N polymorphism by TaqMan assay. Our results showed that MYBPC3 25-bpdeletion polymorphism was significantly associated with elevated risk of LVD (LVEF <45) (healthy controls versus LVD: OR= 3.85,P<0.001; and nonLVD versus LVD: OR=1.65,P=0.035), while TTN 18 bp I/D, TNNT25bpI/Dand myospryn K2906N polymorphisms did not show any significant association with LVD. The results also showed that MYBPC3 25-bp deletion polymorphism was significantly associated with other parameters of LV remodelling, i.e. LV dimensions (LV end diastole dimension, LVEDD: P= 0.037 and LV end systolic dimension, LVESD: P= 0.032).Our data suggests that MYBPC3 25-bp deletion may play significant role in conferring LVD as well as CAD risk in north Indian population

  2. Fractal dimension and architecture of trabecular bone.

    Science.gov (United States)

    Fazzalari, N L; Parkinson, I H

    1996-01-01

    The fractal dimension of trabecular bone was determined for biopsies from the proximal femur of 25 subjects undergoing hip arthroplasty. The average age was 67.7 years. A binary profile of the trabecular bone in the biopsy was obtained from a digitized image. A program written for the Quantimet 520 performed the fractal analysis. The fractal dimension was calculated for each specimen, using boxes whose sides ranged from 65 to 1000 microns in length. The mean fractal dimension for the 25 subjects was 1.195 +/- 0.064 and shows that in Euclidean terms the surface extent of trabecular bone is indeterminate. The Quantimet 520 was also used to perform bone histomorphometric measurements. These were bone volume/total volume (BV/TV) (per cent) = 11.05 +/- 4.38, bone surface/total volume (BS/TV) (mm2/mm3) = 1.90 +/- 0.51, trabecular thickness (Tb.Th) (mm) = 0.12 +/- 0.03, trabecular spacing (Tb.Sp) (mm) = 1.03 +/- 0.36, and trabecular number (Tb.N) (number/mm) = 0.95 +/- 0.25. Pearsons' correlation coefficients showed a statistically significant relationship between the fractal dimension and all the histomorphometric parameters, with BV/TV (r = 0.85, P fractal dimension shows that trabecular bone exhibits fractal properties over a defined box size, which is within the dimensions of a structural unit for trabecular bone. Therefore, the fractal dimension of trabecular bone provides a measure which does not rely on Euclidean descriptors in order to describe a complex geometry.

  3. Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure

    Directory of Open Access Journals (Sweden)

    Polizzi Clara

    2010-11-01

    Full Text Available Abstract Background Accumulating evidence suggests glucagon-like peptide-1 (GLP-1 exerts cardioprotective effects in animal models of myocardial infarction (MI. We hypothesized that chronic treatment with GLP-1 or the exenatide analog AC3174 would improve cardiac function, cardiac remodeling, insulin sensitivity, and exercise capacity (EC in rats with MI-induced chronic heart failure (CHF caused by coronary artery ligation. Methods Two weeks post-MI, male Sprague-Dawley rats were treated with GLP-1 (2.5 or 25 pmol/kg/min, AC3174 (1.7 or 5 pmol/kg/min or vehicle via subcutaneous infusion for 11 weeks. Cardiac function and morphology were assessed by echocardiography during treatment. Metabolic, hemodynamic, exercise-capacity, and body composition measurements were made at study end. Results Compared with vehicle-treated rats with CHF, GLP-1 or AC3174 significantly improved cardiac function, including left ventricular (LV ejection fraction, and end diastolic pressure. Cardiac dimensions also improved as evidenced by reduced LV end diastolic and systolic volumes and reduced left atrial volume. Vehicle-treated CHF rats exhibited fasting hyperglycemia and hyperinsulinemia. In contrast, GLP-1 or AC3174 normalized fasting plasma insulin and glucose levels. GLP-1 or AC3174 also significantly reduced body fat and fluid mass and improved exercise capacity and respiratory efficiency. Four of 16 vehicle control CHF rats died during the study compared with 1 of 44 rats treated with GLP-1 or AC3174. The cellular mechanism by which GLP-1 or AC3174 exert cardioprotective effects appears unrelated to changes in GLUT1 or GLUT4 translocation or expression. Conclusions Chronic treatment with either GLP-1 or AC3174 showed promising cardioprotective effects in a rat model of CHF. Hence, GLP-1 receptor agonists may represent a novel approach for the treatment of patients with CHF or cardiovascular disease associated with type 2 diabetes.

  4. Fractal Dimension in Epileptic EEG Signal Analysis

    Science.gov (United States)

    Uthayakumar, R.

    Fractal Analysis is the well developed theory in the data analysis of non-linear time series. Especially Fractal Dimension is a powerful mathematical tool for modeling many physical and biological time signals with high complexity and irregularity. Fractal dimension is a suitable tool for analyzing the nonlinear behaviour and state of the many chaotic systems. Particularly in analysis of chaotic time series such as electroencephalograms (EEG), this feature has been used to identify and distinguish specific states of physiological function.Epilepsy is the main fatal neurological disorder in our brain, which is analyzed by the biomedical signal called Electroencephalogram (EEG). The detection of Epileptic seizures in the EEG Signals is an important tool in the diagnosis of epilepsy. So we made an attempt to analyze the EEG in depth for knowing the mystery of human consciousness. EEG has more fluctuations recorded from the human brain due to the spontaneous electrical activity. Hence EEG Signals are represented as Fractal Time Series.The algorithms of fractal dimension methods have weak ability to the estimation of complexity in the irregular graphs. Divider method is widely used to obtain the fractal dimension of curves embedded into a 2-dimensional space. The major problem is choosing initial and final step length of dividers. We propose a new algorithm based on the size measure relationship (SMR) method, quantifying the dimensional behaviour of irregular rectifiable graphs with minimum time complexity. The evidence for the suitability (equality with the nature of dimension) of the algorithm is illustrated graphically.We would like to demonstrate the criterion for the selection of dividers (minimum and maximum value) in the calculation of fractal dimension of the irregular curves with minimum time complexity. For that we design a new method of computing fractal dimension (FD) of biomedical waveforms. Compared to Higuchi's algorithm, advantages of this method include

  5. Art meets mathematics in the fourth dimension

    CERN Document Server

    Lipscomb, Stephen Leon

    2014-01-01

    To see objects that live in the fourth dimension we humans would need to add a fourth dimension to our three-dimensional vision. An example of such an object that lives in the fourth dimension is a hyper-sphere or “3-sphere”. The quest to imagine the elusive 3-sphere has deep historical roots: medieval poet Dante Alighieri, in his circa 1300 AD Divine Comedy, used a 3-sphere to convey his allegorical vision of the Christian afterlife. In 1917, Albert Einstein visualized the universe, at each instant in time, as a 3-sphere. He described his representation as “…the place where the reader’s imagination boggles. Nobody can imagine this thing.” Over time, however, our understanding of the concept of dimension evolved. By 2003, a researcher had successfully rendered into human vision the structure of a 4-web (think of an every increasingly-dense spider’s web). In this text Stephen Lipscomb takes his innovative dimension theory research a step further, using the 4-web to reveal a new partial image of a...

  6. Dental Arch Dimension of Malay Ethnic Group

    Directory of Open Access Journals (Sweden)

    H. A. Mohammad

    2011-01-01

    Full Text Available Problem statement: Many previous studies tried to define and put specific measurements for dental arches dimension in different ethnics groups. However, these studies may be specific to an ethnic group and cannot always be applied to other ethnic types. The aim of this study: is to obtain specific dental arch dimensions for Malaysian Malay ethnic groups and compare between both genders. Approach: Involved clinical examination, collection and analysis of 60 dental cast of Malaysian Malay subjects from pure ethnic group (30 males and 30 females, 20-24 years old. All dental landmarks were located and determined and subsequently measurements had been done according to specific points have been selected. Statistical analysis were done using t-test. Results: Dental arch dimension were established in normal occlusion for Malaysian Malay ethnic group in this study. No significant difference was observed in arch dimensions between male and female of Malaysian Malay. Conclusion: These measurement should be considered during treatment, especially in prosthodontics and orthodontics where arch dimension can be modified appreciably.

  7. Massively Parallel Dimension Independent Adaptive Metropolis

    KAUST Repository

    Chen, Yuxin

    2015-05-14

    This work considers black-box Bayesian inference over high-dimensional parameter spaces. The well-known and widely respected adaptive Metropolis (AM) algorithm is extended herein to asymptotically scale uniformly with respect to the underlying parameter dimension, by respecting the variance, for Gaussian targets. The result- ing algorithm, referred to as the dimension-independent adaptive Metropolis (DIAM) algorithm, also shows improved performance with respect to adaptive Metropolis on non-Gaussian targets. This algorithm is further improved, and the possibility of probing high-dimensional targets is enabled, via GPU-accelerated numerical libraries and periodically synchronized concurrent chains (justified a posteriori). Asymptoti- cally in dimension, this massively parallel dimension-independent adaptive Metropolis (MPDIAM) GPU implementation exhibits a factor of four improvement versus the CPU-based Intel MKL version alone, which is itself already a factor of three improve- ment versus the serial version. The scaling to multiple CPUs and GPUs exhibits a form of strong scaling in terms of the time necessary to reach a certain convergence criterion, through a combination of longer time per sample batch (weak scaling) and yet fewer necessary samples to convergence. This is illustrated by e ciently sampling from several Gaussian and non-Gaussian targets for dimension d 1000.

  8. Accelerated Dimension-Independent Adaptive Metropolis

    KAUST Repository

    Chen, Yuxin

    2016-10-27

    This work describes improvements by algorithmic and architectural means to black-box Bayesian inference over high-dimensional parameter spaces. The well-known adaptive Metropolis (AM) algorithm [H. Haario, E. Saksman, and J. Tamminen, Bernoulli, (2001), pp. 223--242] is extended herein to scale asymptotically uniformly with respect to the underlying parameter dimension for Gaussian targets, by respecting the variance of the target. The resulting algorithm, referred to as the dimension-independent adaptive Metropolis (DIAM) algorithm, also shows improved performance with respect to adaptive Metropolis on non-Gaussian targets. This algorithm is further improved, and the possibility of probing high-dimensional (with dimension $d \\\\geq 1000$) targets is enabled, via GPU-accelerated numerical libraries and periodically synchronized concurrent chains (justified a posteriori). Asymptotically in dimension, this GPU implementation exhibits a factor of four improvement versus a competitive CPU-based Intel MKL (math kernel library) parallel version alone. Strong scaling to concurrent chains is exhibited, through a combination of longer time per sample batch (weak scaling) with fewer necessary samples to convergence. The algorithm performance is illustrated on several Gaussian and non-Gaussian target examples, in which the dimension may be in excess of one thousand.

  9. Dark Energy as Evidence for Extra Dimensions

    CERN Document Server

    Milton, K A

    2003-01-01

    It is argued that fluctuations of quantum fields in four-dimensional space do not give rise to dark energy, but are rather a negligible contribution to dark matter. By (relativistic) dark matter we mean that the relation between pressure and energy density is $p=\\frac13 u$, while dark energy is characterized by $p=-u$. A possible source of dark energy are the fluctuations in quantum fields, including quantum gravity, inhabiting extra compactified dimensions. These fluctuations have been computed for some simple geometries, such as $S^2$, $S^4$, and $S^6$. If the extra dimensions are too small, they would give rise to a dark energy larger than that observed, whereas if they are too large they would be in conflict with experimental tests of Newton's law. This notion suggests that the size of the extra dimensions is of order 100 $\\mu$m. If the limit on the size of extra dimensions becomes lower than this bound, extra dimensions probably do not exist, and another source for cosmological dark energy will have to b...

  10. Assessing the match between female primary students’ anthropometric dimensions and furniture dimensions in Hamadan schools in 2013

    Directory of Open Access Journals (Sweden)

    R. Heidarimoghadam

    2015-04-01

    Conclusion: Despite differences in the body dimensions of primary school students, there is no regularity in using of school furniture. Overall, the dimensions of existing benches and desks are not matched with the anthropometric dimensions of students.

  11. 中低压直流配电系统的主动保护研究%Research on Active Protection for MV/LV DC Distribution System

    Institute of Scientific and Technical Information of China (English)

    吴鸣; 刘海涛; 陈文波; 苏剑; 季宇; 孙丽敬; 王丽

    2016-01-01

    Due to the vast access of distributed energies, the rapid growth of DC loads and the rapid development of power electronics, the DC distribution is more and more concerned, and DC power distribution system will become an important part of distribution network in the future. The protection in the DC distribution system is a core problem during rapid development of the DC distribution system, and the lucubration is urgent. Aiming at common faults such as short-circuit, ground, ring network, AC releasing into DC system and insulation decreasing fault in MV/LV DC distribution system, this paper analyzed faults characteristics and their developing process, and it proposed a power electronic protection strategy, effectively integrating the DC protection with the power electronic converters. The strategy can realize the protection and failure isolation based on the topology structure and the operation mechanism of the converter, the effective coordination between the protection action logic and control logic. And this paper expounded the applications and component of the DC active protection, analyzed the principle and method of the active protections, expounded the active ground fault protection and short-circuit fault protection, and came up with the fault mechanism and active solution method in the DC ring network and AC releasing into DC system network. At last validating through actual cases, the result shows that active protection can realize the rapid and accurate isolation of the faults in DC distribution system, and ensure the system run steadily and reliably.%分布式发电和储能的大量接入、直流负荷的快速增长、电力电子技术的迅速发展,使得直流配电越来越受关注.直流配电系统将会成为未来配电技术的一个重要组成部分.但直流配电保护是直流配电系统快速发展的一个关键问题,亟需深入研究.针对中低压直流配电网中常见的短路、接地、环网、交直流混接、绝缘

  12. Modeling of LV Distribution Network Based on Metering Data%基于量测数据的低压配电网精确建模

    Institute of Scientific and Technical Information of China (English)

    栾文鹏; 王兵; 周宁; 郭志民

    2015-01-01

    低压配电网的电力线路参数是对其进行潮流计算、线损分析、窃电监测等的基础,而目前对于这方面的研究并不多,主要是由于无法获得低压配电网的量测数据。文章研究了基于高级量测体系(advanced metering infrastructure,AMI)提供的量测数据计算低压配电网线路参数的方法,以达到对配电网络精确建模的目的。该方法是在已知配电网拓扑的前提下利用智能电表所采集到的电压、有功功率和无功功率数据,通过计算上游节点电压,搭建求解优化问题的模型,使时间序列内不同电表数据计算得到的上游节点电压方差最小,或计算得到的该点电压和该点测量电压的差值最小,从而得到配电网线路的阻抗参数,实现配电网络的精确建模。最后以包含17个电表节点和21条支路的实际配网算例验证了所提方法的有效性。%For a long time, due to various reasons, power utilities don’t have full or accurate mastering of information of LVdistribution network. This is one of the cases for distribution networkparameters.Accuratecircuit parameters of LVdistribution network are basis of power flow calculation, loss analysis andenergytheftdetection.Electricalparameters are important, but research on them is far from sufficient mainly because of absence of measured data inLVdistribution network.Implementation ofadvanced metering infrastructure (AMI)provides new ways for solving this problem. Thispaper researchesapproacheson accurateelectricalcircuit parameter calculation inLVdistribution networkusing smart meter measurements,so as toobtain accurate model ofLV distribution network.Provided distribution network topology is known, the method leverages a series of smart meter measurements at end nodes of distribution network, mainly voltage, active power and reactive power at customer sides. It calculates voltage of the most upstream node or source node in radial

  13. Flatland a journey of many dimensions

    CERN Document Server

    2007-01-01

    "Flatland" is based on Edwin A. Abbott's classic novel : Flatland : a romance of many dimensions. Flatland is a world that exists entirely on a two-dimensional plane. All different kinds of shapes live, work and play in this world. The story follows Arthur Square (Martin Sheen) and his curious granddaughter Hex (Kristen Bell). When a mysterious visitor (Michael York) arrives from Spaceland, Arthur and Hex must come to terms with the truth of the third dimension, risking dire consequences from the evil Circles that have ruled Flatland for thousands of years. "Flatland" is an animated story that includes action, drama, and geometry lessons. This heartfelt movie challenges audiences to grasp the limitations of our own assumptions about reality, and to think about the idea of higher dimensions.

  14. Composite p-branes in various dimensions

    CERN Document Server

    Aref'eva, I Ya; Volovich, I V

    1997-01-01

    We review an algebraic method of finding the composite p-brane solutions for a generic Lagrangian, in arbitrary spacetime dimension, describing an interaction of a graviton, a dilaton and one or two antisymmetric tensors. We set the Fock--De Donder harmonic gauge for the metric and the "no-force" condition for the matter fields. Then equations for the antisymmetric field are reduced to the Laplace equation and the equation of motion for the dilaton and the Einstein equations for the metric are reduced to an algebraic equation. Solutions composed of n constituent p-branes with n independent harmonic functions are given. The form of the solutions demonstrates the harmonic functions superposition rule in diverse dimensions. Relations with known solutions in D=10 and D=11 dimensions are discussed.

  15. Material and lighting dimensions of object colour.

    Science.gov (United States)

    Tokunaga, Rumi; Logvinenko, Alexander D

    2010-08-06

    The dimensionality of the object colour manifold was studied using a multidimensional scaling technique, which allows for the representation of a set of coloured papers as a configuration in a Euclidean space where the distance between papers corresponds to the perceptual dissimilarities between them. When the papers are evenly illuminated they can be arranged as a three-dimensional configuration. This is in line with the generally accepted view that the object colour space is three-dimensional. Yet, we show that under variegated illumination another three dimensions emerge. We call them lighting dimensions of object colour in order to distinguish from the traditional three referred to as material dimensions of object colour. Copyright 2010 Elsevier Ltd. All rights reserved.

  16. Experiential Dimensions of TV-Advertising

    DEFF Research Database (Denmark)

    Andersen, Lars Pynt; Jensen, Jan Møller

    Based on concepts from cognitive film psychology and narrative transportation theory a model of the experiential dimensions of TV–advertising is proposed. With structural equation modeling, it is shown how the ad’s experiential potential relates to Ad-Liking. Findings indicate that Ad-Liking is h......Based on concepts from cognitive film psychology and narrative transportation theory a model of the experiential dimensions of TV–advertising is proposed. With structural equation modeling, it is shown how the ad’s experiential potential relates to Ad-Liking. Findings indicate that Ad......-Liking is highly related to narrative advertising executions, but that the potential appeal of this advertising experience is supported by the ‘gripping’ qualities of a lyrical dimension. It is suggested that the conceptual framework could be developed for pragmatic comparison of TV-spots in tracking or testing....

  17. Sociotechnical Dimensions of Design and Innovation

    DEFF Research Database (Denmark)

    , as well as political process and design management oriented approaches. The research contributions examined stem primarily from international periodicals, book publications, and selected conference papers, and all attend, explicitly or otherwise, to “sociotechnical” dimensions in the processes of design...... of the sociotechnical dimensions of innovation processes. The paper’s analysis is itself guided by a reflexive stance as to the ‘social shaping of technology’, primarily drawing on an actor-network (ANT) understanding and perspectives based on the enculturation of innovations (e.g. inno-fusion or domestication...... of technology). The paper thus challenges the orthodox linear and sequential model of innovation and diffusion, which fail to capture and problematise the complexity of the dynamics involved in sociotechnical change. The paper takes a relatively broad stance as to what constitutes sociotechnical dimensions...

  18. Neurocognitve Dimensions of Self-consciousness

    Directory of Open Access Journals (Sweden)

    Dario Grossi

    2016-04-01

    Full Text Available Self-consciousness is considered in a framework comprising four dimensions which are theoretically defined and supported by clinical neuropsychological evidence. Self-monitoring is defined as the ability to reflect on one’s own behaviour, with supporting evidence for deficits in this capacity noted in anosognosia syndrome. Self-feeling is defined as the capacity to feel all sensations related to one’s own body (interoception and exteroception, with supporting evidence from deficiencies occurring in alexithymia, psychosomatic states and Cotard’s delusion. Identity refers to the capacity to recognize an object as identical to oneself, based on autobiographic memory; pathological conditions related to this dimension include delusions of identity and the Zelig syndrome. Ownership is the capacity to perceive the status of ones’ own body, and is clinically altered in somatoparaphrenia. All four dimensions are related to specific brain networks.

  19. Soft-/rapidity- anomalous dimensions correspondence

    CERN Document Server

    Vladimirov, Alexey A

    2016-01-01

    We establish a correspondence between ultraviolet singularities of soft factors for multi-particle production and rapidity singularities of soft factors for multi-parton scattering. This correspondence is a consequence of a conformal mapping between scattering geometries. The correspondence is valid to all orders of perturbation theory and in this way provides a proof of rapidity renormalization procedure for multi-parton scattering soft factors (including the transverse momentum dependent (TMD) soft factor as a special case). As a by-product we obtain an exact relation between the rapidity anomalous dimension and the well-known soft anomalous dimension. The three-loop rapidity anomalous dimensions for TMD and a general multi-parton scattering are derived.

  20. Dual Projection and Selfduality in Three Dimensions

    CERN Document Server

    Banerjee, R; Banerjee, Rabin; Wotzasek, Clovis

    2001-01-01

    We discuss the notion of duality and selfduality in the context of the dual projection operation that creates an internal space of potentials. Contrary to the prevailing algebraic or group theoretical methods, this technique is applicable to both even and odd dimensions. The role of parity in the kernel of the Gauss law to determine the dimensional dependence is clarified. We derive the appropriate invariant actions, discuss the symmetry groups and their proper generators. In particular, the novel concept of duality symmetry and selfduality in Maxwell theory in (2+1) dimensions is analysed in details. The corresponding action is a 3D version of the familiar duality symmetric electromagnetic theory in 4D. Finally, the duality symmetric actions in the different dimensions constructed here manifest both the SO(2) and $Z_2$ symmetries, contrary to conventional results.

  1. Compact Extra Dimensions in Quantum Mechanics

    CERN Document Server

    Deutschmann, Nicolas

    2016-01-01

    Extra-dimensions are a common topic in popular descriptions of theoretical physics with which undergraduate student most often have no contact in physics courses. This paper shows how students could be introduced to this topic by presenting an approach to two basic consequences of the presence of compact extra-dimensions based on undergraduate-level physics. The insensibility of low-energy physics to compact extra dimensions is illustrated in the context of non-relativistic quantum mechanics and the prediction of Kaluza-Klein excitations of particles is discussed in the framework of relativistic wave-equations. An exercise that could be used as a follow-up to the "particle in a box" is proposed.

  2. The "fourth dimension" of gene transcription.

    Science.gov (United States)

    O'Malley, Bert W

    2009-05-01

    The three dimensions of space provide our relationship to position on the earth, but the fourth dimension of time has an equally profound influence on our lives. Everything from light and sound to weather and biology operate on the principle of measurable temporal periodicity. Consequently, a wide variety of time clocks affect all aspects of our existence. The annual (and biannual) cycles of activity, metabolism, and mating, the monthly physiological clocks of women and men, and the 24-h diurnal rhythms of humans are prime examples. Should it be surprising to us that the fourth dimension also impinges upon gene expression and that the genome itself is regulated by the fastest running of all biological clocks? Recent evidence substantiates the existence of such a ubiquitin-dependent transcriptional clock that is based upon the activation and destruction of transcriptional coactivators.

  3. 2-Dimension Interleaver Design for IDMA Systems

    Institute of Scientific and Technical Information of China (English)

    Jian-Hao Hu; Cheng-Hai Zhang; Ling Xiang

    2009-01-01

    A new design method interleavers, 2-dimension interleavers, are proposed for interleave division multiple access (IDMA) systems. With a same interleaving rule named Γ the row indices and column indices of a traditional block interleaving matrix are scrambled to obtain an interleaver, which is marked as the master interleaver.Γ is produced by a low- order PN sequence generator. Two ways are provided for generating different interleavers. One is that all interleavers are generated by the circular shifting master interleaver. The other is that different inter- leavers are generated by different Γs. Besides, we prove that the minimum distance between two adjacent bits resulted from 2-dimension interleaves is much larger than that of other schemes, such as random interleavers, power interleavers, and shiffting interleaves. The simu- lation results show that 2-dimension interleavers can achieve much better performance with much less resource consumption than random interleavers in IDMA systems.

  4. Faces of platonic solids in all dimensions

    CERN Document Server

    Szajewska, Marzena

    2012-01-01

    This paper considers Platonic solids/polytopes in the real Euclidean space R^n of dimension 3 <= n < infinity. The Platonic solids/polytopes are described together with their faces of dimensions 0 <= d <= n-1. Dual pairs of Platonic polytopes are considered in parallel. The underlying fi?nite Coxeter groups are those of simple Lie algebras of types An, Bn, Cn, F4 and of non-crystallographic Coxeter groups H3, H4. Our method consists in recursively decorating the appropriate Coxeter-Dynkin diagram. Each recursion step provides the essential information about faces of a speci?c dimension. If, at each recursion step, all of the faces are in the same Coxeter group orbit, i.e. are identical, the solid is called Platonic.

  5. Neutrino anomalies and large extra dimensions

    CERN Document Server

    Dighe, A S; Dighe, Amol S.; Joshipura, Anjan S.

    2001-01-01

    Theories with large extra dimensions can generate small neutrino masses when the standard model neutrinos are coupled to singlet fermions propagating in higher dimensions. The couplings can also generate mass splittings and mixings among the flavour neutrinos in the brane. We systematically study the minimal scenario involving only one singlet bulk fermion coupling weakly to the flavour neutrinos. We explore the neutrino mass structures in the brane that can potentially account for the atmospheric, solar and LSND anomalies simultaneously in a natural way. We demonstrate that in the absence of a priori mixings among the SM neutrinos, it is not possible to reconcile all these anomalies. The presence of some structure in the mass matrix of the SM neutrinos can solve this problem. This is exemplified by the Zee model, which when embedded in extra dimensions in a minimal way can account for all the neutrino anomalies.

  6. The Social Dimension of EU Trade Policies

    DEFF Research Database (Denmark)

    Manners, Ian

    2009-01-01

    This special issue on the social dimension of European Union (EU) external trade relations analyses the commitment, capacity, and consequences of the EU as a global social power. In other words, is the EU committed to social principles? Does it have the capacity to engage in persuasive actions......? And what are the consequences of its socialising impact in promoting the social dimension of globalisation through trade? These are all difficult questions to ask of any actor in global politics, let alone a hybrid polity such as the EU. The special issue also addressed two tensions at the heart of the EU......'s social dimension in trade relations - human rights versus welfare concerns and exclusive competence versus lack of competence. These questions and tensions are rendered more methodologically problematic by the existence and activities of other actors and trading powers, such as the International Labour...

  7. Uniform dimension results for Gaussian random fields

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Let X = {X(t),t ∈ RN} be a Gaussian random field with values in Rd defined by X(t) =(X1(t),...,Xd(t)), t ∈ RN.(1) The properties of space and time anisotropy of X and their connections to uniform Hausdorff dimension results are discussed.It is shown that in general the uniform Hausdorff dimension result does not hold for the image sets of a space-anisotropic Gaussian random field X.When X is an(N,d)-Gaussian random field as in(1),where X1,...,Xd are independent copies of a real valued,centered Gaussian random field X0 which is anisotropic in the time variable.We establish uniform Hausdorff dimension results for the image sets of X.These results extend the corresponding results on one-dimensional Brownian motion,fractional Brownian motion and the Brownian sheet.

  8. Mediation of supersymmetry breaking in extra dimensions

    CERN Document Server

    Scrucca, C A

    2004-01-01

    I review the mechanisms of supersymmetry breaking mediation that occur in sequestered models, where the visible and the hidden sectors are separated by an extra dimension and communicate only via gravitational interactions. By locality, soft breaking terms are forbidden at the classical level and reliably computable within an effective field theory approach at the quantum level. I present a self-contained discussion of these radiative gravitational effects and the resulting pattern of soft masses, and give an overview of realistic model building based on this set-up. I consider both flat and warped extra dimensions, as well as the possibility that there be localized kinetic terms for the gravitational fields.

  9. Anomalous mass dimension in multiflavor QCD

    Science.gov (United States)

    Doff, A.; Natale, A. A.

    2016-10-01

    Models of strongly interacting theories with a large mass anomalous dimension (γm) provide an interesting possibility for the dynamical origin of the electroweak symmetry breaking. A laboratory for these models is QCD with many flavors, which may present a nontrivial fixed point associated to a conformal region. Studies based on conformal field theories and on Schwinger-Dyson equations have suggested the existence of bounds on the mass anomalous dimension at the fixed points of these models. In this note we discuss γm values of multiflavor QCD exhibiting a nontrivial fixed point and affected by relevant four-fermion interactions.

  10. The Higgs Mechanism from an extra dimension

    CERN Document Server

    A., Yu

    2016-01-01

    The standard $SU(2) \\times U(1)$ fields are considered in 4D plus one extra compact dimension. As a result two basic effects are obtained. First, four Goldstone-like scalars are produced, three of them are used to create longitudinal modes of the $W,Z$ fields, while the fourth becomes the Higgs-like scalar. Second, $W$ and $Z$ get their masses from the extra compact dimension with the standard pattern of symmetry violation. The resulting theory has the same fields as in the standard model, but without the Higgs vacuum average. The properties of the new Higgs scalar and its interaction with fermions are briefly discussed.

  11. Phenomenology of symmetry breaking from extra dimensions

    CERN Document Server

    Alfaro, J; Gavela-Legazpi, Maria Belen; Rigolin, S; Salvatori, M

    2007-01-01

    Motivated by the electroweak hierarchy problem, we study the symmetry breaking pattern induced by a background magnetic flux living on extra dimensions, with the four-dimensional scalar fields being gauge boson components in full space. For SU(N) and two compact, toroidal, extra dimensions, we determine analytically the possible field configurations of stable vacua and their symmetries. From the four-dimensional point of view, the system responds dynamically to the magnetic background by an infinite chain of vacuum expectation values so as to reach a stable vacuum. The equivalence between flux compactification and constant boundary conditions - either Scherk-Schwarz or twisted - is established.

  12. The Dimension of Projections of Fractal Percolations

    Science.gov (United States)

    Rams, Michał; Simon, Károly

    2014-02-01

    Fractal percolation or Mandelbrot percolation is one of the most well studied families of random fractals. In this paper we study some of the geometric measure theoretical properties (dimension of projections and structure of slices) of these random sets. Although random, the geometry of those sets is quite regular. Our results imply that, denoting by a typical realization of the fractal percolation on the plane, If then for all lines ℓ the orthogonal projection E ℓ of E to ℓ has the same Hausdorff dimension as E,

  13. National narcissism: Internal dimensions and international correlates.

    Science.gov (United States)

    Cai, Huajian; Gries, Peter

    2013-08-01

    In studies conducted in the United States and China, we explored the impact of national narcissism, grandiosity, and entitlement, demonstrating that: (a) national narcissism was distinct from both individual narcissism and collective self-esteem (patriotism); (b) national entitlement and national grandiosity constituted two distinct dimensions of national narcissism; and (c) national narcissism, national grandiosity, and national entitlement, but not individual narcissism, were uniquely predictive of political attitudes, foreign policy preferences, and purchase intentions. Together, these findings provided convergent evidence for the utility of national narcissism and its two internal dimensions, national entitlement and national grandiosity.

  14. [A failed improvement in pulmonary function and exercise capacity with carvedilol in congestive heart failure despite an excellent effect on left ventricular function].

    Science.gov (United States)

    Guazzi, M; Pontone, G; Trevisi, N; Lomanto, M; Matturri, M; Agostoni, P

    1998-02-01

    This study was aimed at investigating in chronic heart failure (CHF) the effects that beta-blockade with carvedilol may have on lung function, and their relationship with left ventricular (LV) performance and peak exercise oxygen uptake (VO2p). CHF causes disturbances in ventilation and pulmonary gas transfer (stress failure of alveolar-capillary membrane) that participate in limiting VO2p. Carvedilol improves LV function and not VO2p. Twenty-one NYHA functional class II-III patients were randomized (2 to 1) to carvedilol (25 mg bid., 14 patients) or placebo (7 patients) for 6 months. Rest forced expiratory volume (FEV1), vital capacity (VC), total lung capacity (TLC), carbon monoxide diffusing capacity (DLCO), its alveolar-capillary membrane component (DM), pulmonary venous and transmitral flows (for monitoring changes in LV end-diastolic pressure, EDP), LV diastolic (EDD) and systolic (ESD) dimensions, stroke volume (SV), ejection fraction (EF), fiber shortening velocity (VCF) were measured at baseline and at 3 and 6 months. VO2p, peak ratio of dead space to tidal volume (VD/VTp), ventilatory equivalent for CO2 production (VE/VCO2), VO2 at anaerobic threshold (VO2at) were also determined. FEV1, VC, TLC, DLCO, DM were impaired in CHF compared to 14 volunteers, and did not vary with treatment. Carvedilol reduced EDP, EDD, ESD, and increased EF, SV, VCF, without affecting VO2p, VO2at, VD/VTp, VE/VCO2, at 3 and 6 months. Placebo was ineffective. In CHF, carvedilol exerts neutral effects on ventilation and pulmonary gas transfer and ameliorates LV function at rest. This proves that antifailure treatment may not be similarly effective on cardiac and pulmonary function; and does not contradict the possibility that persistence of lung impairment may contribute to lack of improvement in exercise performance with carvedilol.

  15. Model-driven segmentation of X-ray left ventricular angiograms

    NARCIS (Netherlands)

    Oost, Cornelis Roel

    2008-01-01

    X-ray left ventricular (LV) angiography is an important imaging modality to assess cardiac function. Using a contrast fluid a 2D projection of the heart is obtained. In current clinical practice cardiac function is analyzed by drawing two contours manually: one in the end diastolic (ED) phase and on

  16. Longitudinal echocardiographic follow-up in children with congenital complete atrioventricular block

    NARCIS (Netherlands)

    Beaufort-Krol, Gertie C. M.; Leeuwen, Miek J. M. Schasfoort-Van; Stienstra, Ymkje; Bink-Boelkens, Margreet Th. E.

    2007-01-01

    Background: Due to a low heart rate (HR) in children with congenital complete atrioventricular block (CCAVB), a larger stroke volume of the left ventricle (LV) may be expected. If so, end-diastolic (LVEDD) and end-systolic (LVESD) diameters may be enlarged and even dilated cardiomyopathy (DCM) may o

  17. Age-related changes in cardiovascular performance in mitral regurgitation: analysis of 61 patients.

    Science.gov (United States)

    Clancy, K F; Iskandrian, A S; Hakki, A H; Nestico, P; DePace, N L

    1985-03-01

    This study examines the cardiovascular performance in relation to age in 61 patients with moderate or severe chronic mitral regurgitation (MR). Coronary artery disease (CAD) (50% or more diameter narrowing of one or more major coronary arteries) was present in 20 patients (33%). Patients less than 60 years (n = 33) had lower pulmonary artery pressure, systolic arterial pressure, left ventricular (LV) end-diastolic pressure, and pulmonary artery wedge pressure than the patients greater than or equal to 60 years (n = 28) (p less than 0.05). In the 41 patients without associated CAD, the LV end-diastolic pressure and systemic arterial pressure were higher in patients greater than or equal to 60 years (n = 14) than patients less than 60 years (n = 27) (p less than 0.05). The LV end-diastolic pressure showed an age-related increase in the presence or absence of CAD. Thus, older patients with MR have higher LV end-diastolic pressure, probably because of an increase in myocardial stiffness.

  18. Supersymmetric R4-actions in ten dimensions

    NARCIS (Netherlands)

    Roo, M. de; Suelmann, H.; Wiedemann, A.

    1992-01-01

    We construct supersymmetric R+R4-actions in ten dimensions. Two invariants, of which the bosonic parts are known from string amplitude and sigma model calculations, are obtained. One of these invariants can be generalized to an R+F2+F4-invariant for supersymmetric Yang-Mills theory coupled to superg

  19. p-Brane Solutions in Diverse Dimensions

    CERN Document Server

    Aref'eva, I Ya; Volovich, I V

    1996-01-01

    A generic Lagrangian, in arbitrary spacetime dimension, describing the interaction of a graviton, a dilaton and two antisymmetric tensors is considered. An isotropic p-brane solution consisting of three blocks and depending on four parameters in the Lagrangian and two arbitrary harmonic functions is obtained. For specific values of parameters in the Lagrangian the solution may be identified with previously known superstring solutions.

  20. Endangered Species: Real Life in Two Dimensions

    Science.gov (United States)

    Henderson, Lynette K.

    2012-01-01

    The focus of "Endangered Species: Real Life in Two Dimensions" is to create awareness about a critical environmental issue. There is a special urgency to this project because large numbers of animal species are currently endangered or on the brink of extinction. In addition to being enlightened about this important topic through research, students…